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+[{"audio_id": "faRP78Q8AuE", "text": {"faRP78Q8AuE-00000-00000006-00000636": "having production know you a little bit about your personality having that Advantage I think", "faRP78Q8AuE-00001-00000636-00001182": "is really important I believe is really important because people want to work with people that they", "faRP78Q8AuE-00002-00001182-00001698": "trust and that they're excited to have on site but how do you have production know who you are", "faRP78Q8AuE-00003-00001698-00002196": "before auditioning for them like how do you even meet these people industry events so let's go to", "faRP78Q8AuE-00004-00002196-00002700": "some mixers together let's go to this Aura casting event I've talked about Aura before", "faRP78Q8AuE-00005-00002700-00003246": "it's an online Casting Company 100% online if you're an actor in the US go ahead and", "faRP78Q8AuE-00006-00003246-00003672": "submit yourself you just put your photos your information if you do have a rep they will send", "faRP78Q8AuE-00007-00003672-00004086": "the information to them when they have casting calls if not they'll send them directly to you,", "faRP78Q8AuE-00008-00004086-00004698": "you can do a self tape and then you can get booked as far as I know mostly in California although I", "faRP78Q8AuE-00009-00004698-00005292": "have seen some stuff in Colorado for them let's go to this Aura casting event people are starting to", "faRP78Q8AuE-00010-00005292-00006030": "get here because it's like just past seven there's a bunch of vendors here so I am doing a raffle I'm", "faRP78Q8AuE-00011-00006030-00006576": "going to 53-inch paper backdrops just like this one you all you have to do is subscribe to my", "faRP78Q8AuE-00012-00006576-00007122": "channel and then I'm going to be giving away two later today and then um there's gonna be a bunch", "faRP78Q8AuE-00013-00007122-00007760": "of entertainment I'm an actor and YouTube Content Creator and today I'm here thanks to Taylor", "faRP78Q8AuE-00014-00007859-00008358": "um and I'm just showing you guys who I am I'm a master and I like to share about myself on YouTube", "faRP78Q8AuE-00015-00008466-00009168": "um and also just my experience as an actor so myself audition setup is over there today", "faRP78Q8AuE-00016-00009270-00010410": "yeah and I feel like not enough people inside yet so I'm just gonna contact Savage Universal which", "faRP78Q8AuE-00017-00010410-00011124": "is Who provided the backdrops and ask them for one more so if you have it um entered come back after", "faRP78Q8AuE-00018-00011124-00011640": "and I'm gonna have you guys enter the rest of you but the person that's going to win the 53-inch", "faRP78Q8AuE-00019-00011640-00012294": "uh in super white is I emailed Savage I haven't heard back so I'm pretty sure they're gonna say", "faRP78Q8AuE-00020-00012294-00013056": "yes but if they say no guess who's going to use her credit card so let's choose a winner for the", "faRP78Q8AuE-00021-00013056-00013728": "third paper backdrop look at all the people that entered whoa okay I did take out already the two", "faRP78Q8AuE-00022-00013728-00015006": "people that won at the event but I'm doing a third one because I wanted to oh that's blank", "faRP78Q8AuE-00023-00015006-00015606": "no way Lorena Flores um she is a subscriber so maybe you are watching this Lorena", "faRP78Q8AuE-00024-00015672-00016050": "um she told me her last name was Flores and I was like wait you know my last name is Flores", "faRP78Q8AuE-00025-00016050-00016734": "too so I was like we're cousins so my cousin won this we're not actual cousin Lorena DM me", "faRP78Q8AuE-00026-00016734-00017148": "um give me actually I'll DM you because I just started following you on Instagram too you won", "faRP78Q8AuE-00027-00017148-00017604": "I'm gonna send you this video and you better watch this I'm not gonna tell you you won I'm just gonna", "faRP78Q8AuE-00028-00017604-00018066": "send you this video and once you watch it you're gonna know you won but you want a 53-inch paper", "faRP78Q8AuE-00029-00018066-00018564": "backdrop so what you're gonna do is you're gonna send me your email and then I'm gonna put you in", "faRP78Q8AuE-00030-00018564-00019074": "touch with Savage and you can choose whatever 53-inch paper backdrop you want whatever color", "faRP78Q8AuE-00031-00019074-00019632": "or I'm just gonna use my credit card and I'll send it to you via Amazon maybe it's not the case but", "faRP78Q8AuE-00032-00019632-00020244": "is it because like do they have these vendors in part to warm people up you know if you're", "faRP78Q8AuE-00033-00020244-00020802": "coming by yourself and you don't really know who to talk to somebody easy to approach is somebody", "faRP78Q8AuE-00034-00020802-00021438": "who's selling things warm-up conversations with the vendors first and then you can continue and", "faRP78Q8AuE-00035-00021438-00021852": "talk to more people and you can be like hey did you visit the candle place they had some pretty", "faRP78Q8AuE-00036-00021852-00022404": "cool names on their candles conversation starters is that why there's funders networking wise for me", "faRP78Q8AuE-00037-00022404-00023106": "I met so many actors a lot of people actually came up to my booth like my self tape setup thinking it", "faRP78Q8AuE-00038-00023106-00023574": "was for photos and they were asking me like oh can I take a photo here you know of course they", "faRP78Q8AuE-00039-00023574-00023982": "could but I would also tell them like oh this is actually my soft tape audition setup I'm an", "faRP78Q8AuE-00040-00023982-00024600": "actor and I would ask them what they use for their backdrops a few of them said the wall or that they", "faRP78Q8AuE-00041-00024600-00025212": "used a pop-up one or I showed them how a full body shot would look like with a seamless paper because", "faRP78Q8AuE-00042-00025212-00025698": "it's nice and clean you don't see the edges of the pop-up backdrop or anything I want to say", "faRP78Q8AuE-00043-00025698-00026544": "I met around 30 actors I only filmed a portion of the people that I actually met I said hello to an", "faRP78Q8AuE-00044-00026544-00027048": "owner of a production company that I've worked with before he's also director the DP for that", "faRP78Q8AuE-00045-00027048-00027606": "production company I met another owner two more owners of production companies one in Sacramento", "faRP78Q8AuE-00046-00027606-00028314": "and one of the Bay Area I met a few agents um one of them was Dina from Sacramento who also reps", "faRP78Q8AuE-00047-00028314-00028950": "people in the Bay Area 350 people it really felt like so many more but because there were vendors", "faRP78Q8AuE-00048-00028950-00029460": "and circus performers there's a DJ really good music photo booth like there were so many things", "faRP78Q8AuE-00049-00029460-00029933": "where everybody was like walking around so it's not like you stayed in the same Circle at least I", "faRP78Q8AuE-00050-00029933-00030408": "didn't see that you really got to move around and talk to people and people were introducing people", "faRP78Q8AuE-00051-00030408-00030912": "and throughout the event um people would just ask me like hey do you know this or that or when", "faRP78Q8AuE-00052-00030912-00031416": "I said hello to my friend who owns a production company I was like do you want to meet some actors", "faRP78Q8AuE-00053-00031416-00031950": "or like shirts so I like grabbed my friend Justin and I was like Justin meet Max and you know just", "faRP78Q8AuE-00054-00031950-00032610": "like I I just the energy was really good and I think it's all because of Taylor and Emily", "faRP78Q8AuE-00055-00032676-00033396": "um they have such a friendly open energy sometimes casting directors can get very overwhelmed and", "faRP78Q8AuE-00056-00033396-00034170": "overworked or agents but I think Taylor and Emily do a really good job of keeping a positive light", "faRP78Q8AuE-00057-00034170-00034770": "energy and this event I believe was definitely a success if you were at the event please leave", "faRP78Q8AuE-00058-00034770-00035154": "me a comment tell me that you're here because I was so excited to meet some people that actually", "faRP78Q8AuE-00059-00035154-00035712": "watch my videos thank you so much to Aura please go check them out on Instagram and you can submit", "faRP78Q8AuE-00060-00035712-00036324": "yourself on their website and thank you so much to Savage Universal for gifting these", "faRP78Q8AuE-00061-00036324-00037032": "paper backdrops again not sponsored at all there's a lot more mixers in December that", "faRP78Q8AuE-00062-00037032-00037602": "I'm going to go to LA and San Francisco Bay area so let me know if you know of any that", "faRP78Q8AuE-00063-00037602-00038082": "I should go to that you enjoy tell me what your questions are around mixers I'm not an expert", "faRP78Q8AuE-00064-00038082-00038592": "but I can tell you my experience as somebody who actually enjoys going to these things I went to", "faRP78Q8AuE-00065-00038592-00039180": "another huge mixer in Arizona this summer it's this one right here with casting director Bella", "faRP78Q8AuE-00066-00039180-00039714": "Hibbs highly recommend checking her out too she gives out a lot of really helpful information!"}}, {"audio_id": "fbfbUb4kVt8", "text": {"fbfbUb4kVt8-00000-00000136-00000342": "Hello , I am Natasha", "fbfbUb4kVt8-00001-00000384-00001960": "and I wanted to share with you that I have just drawn cards for my new skulls and dragon figurine that I have already presented to you", "fbfbUb4kVt8-00002-00002036-00002938": "and I'll just share which cards have emerged, I wanted to know what energy they carry in them", "fbfbUb4kVt8-00003-00003064-00004228": "and so I asked \"which dragon kind is associated with this dragon skull?\"", "fbfbUb4kVt8-00004-00004270-00005810": "This crystal dragon skull is made of two types of crystal: labradorite and tourmaline, and these are two types of crystal that are strongly connected to the earth element", "fbfbUb4kVt8-00005-00005852-00006508": "so it makes sense that this crystal skull helps well with earthing", "fbfbUb4kVt8-00006-00006598-00007818": "when I asked which dragon species was connected to this dragon skull, the card of the black dragon emerged, the black dragon of saturn", "fbfbUb4kVt8-00007-00007956-00008958": "and very special was that there was also a black dragon card on the back of this card set", "fbfbUb4kVt8-00008-00009122-00009938": "for me this was a nice confirmation that the dragon energy associated with this is a black dragon", "fbfbUb4kVt8-00009-00010044-00010400": "and this helps a lot with grounding, that is beautiful", "fbfbUb4kVt8-00010-00010770-00012278": "here you have my beautiful crystal skull when i asked 'what energy is connected to you? I got the eagle card", "fbfbUb4kVt8-00011-00012374-00013134": "at the info of this card it was mainly written that it helps well to tune into the angelic energy", "fbfbUb4kVt8-00012-00013288-00014454": "and when I asked if the energy of this beautiful skull is feminine or masculine I received the Holy Amethyst card", "fbfbUb4kVt8-00013-00014591-00015510": "clearly a feminine energy. It is anyway a beautiful energy of this crystal skull", "fbfbUb4kVt8-00014-00015710-00016614": "I also drew cards for my beautiful orange dragon statue", "fbfbUb4kVt8-00015-00016730-00017862": "and I asked \"what kind of dragon is connected to you?\" and then the golden atlantis dragon came forward", "fbfbUb4kVt8-00016-00017998-00018758": "it is clearly a golden dragon energy, you can see that from the statue of course", "fbfbUb4kVt8-00017-00018804-00019794": "and I also asked \"do you have a male or a female energy?\" and then I drew the card from Serapis Bey", "fbfbUb4kVt8-00018-00019906-00020242": "also a very golden energy as you see", "fbfbUb4kVt8-00019-00020536-00021426": "the info from the serapis bey card was written that it is strongly connected to the energy of the phoenix", "fbfbUb4kVt8-00020-00021482-00022322": "and the phoenix energy often works together with the golden dragon, so for me this was a nice confirmation", "fbfbUb4kVt8-00021-00022448-00023540": "yes it is a beautiful energy, I am happy that I have drawn these cards, that way I get to know my skulls and dragon figurine well", "fbfbUb4kVt8-00022-00023626-00024154": "I wanted to share this with you, very much love and see you next time"}}, {"audio_id": "fbmS7vtBtAy", "text": {"fbmS7vtBtAy-00000-00000002-00000348": "SUBSCRIBE FOR MORE FUNNY VIDOES", "fbmS7vtBtAy-00001-00000348-00000466": "LIKE IT"}}, {"audio_id": "fbMm87rYPx8", "text": {"fbMm87rYPx8-00000-00000012-00000480": "a lot of my recent short videos have been blowing up, so that's great.", "fbMm87rYPx8-00001-00000582-00001434": "thank you. this is happening, maybe due to a lot of interest in my new videos, and I really like this."}}, {"audio_id": "fcmefaeSfDu", "text": {"fcmefaeSfDu-00000-00000664-00001100": "Hello, dear viewers of the channel \"Duyunov's motors\" and participants of the \"SovElMash\" project.", "fcmefaeSfDu-00001-00001100-00001900": "The main news of the past six months is the start of the preparatory activities for the construction of the design and engineering department the SEZ \"Technopolis Moscow\".", "fcmefaeSfDu-00002-00001900-00002600": "The construction equipment has already been dispatched to the site, and the construction of temporary facilities for the construction camp is well underway.", "fcmefaeSfDu-00003-00002600-00003600": "The company's team have put all their efforts and skills to complete a number of tasks that may seem too easy to some of you, and unmanageable - to others.", "fcmefaeSfDu-00004-00003600-00004400": "But while some people are speculating and being apprehensive, the team of \"SovElMash\" is acting and achieving the planned result, no matter what the obstacles are.", "fcmefaeSfDu-00005-00004400-00004900": "We are offering you to remember what had been done in the course of three years before the construction activities began.", "fcmefaeSfDu-00006-00004900-00005300": "Project preparation", "fcmefaeSfDu-00007-00005300-00006500": "\"SovElMash\" prepares a project for the innovative center where the world's most efficient electric motors will be developed using the \"Slavyanka\" technology. The goal is to build this center on the territory of the special economic zone \"Technopolis \"Moscow\".", "fcmefaeSfDu-00008-00006500-00007500": "The company \"SovElMash\" successfully passes a number of checks and proves to the state commission that it is is ready to implement such an ambitious project. It takes about a year and a half to achieve this goal.", "fcmefaeSfDu-00009-00007500-00007900": "The SEZ resident status", "fcmefaeSfDu-00010-00007900-00008800": "\"SovElMash\" becomes the resident of \"Technopolis \"Moscow\" in February 2019 and takes a lease for a land lot on the territory of the special economic zone.", "fcmefaeSfDu-00011-00008800-00009500": "At this stage, the company needs to prepare all the documentation and start getting ready for the construction. It takes almost six months.", "fcmefaeSfDu-00012-00009500-00009900": "Project documentation", "fcmefaeSfDu-00013-00009900-00011300": "\"SovElMash\" together with the general contractor prepare the project documentation and the engineering survey results to submit to the state examination agency. It takes about six months to elaborate the engineering center project.", "fcmefaeSfDu-00014-00011300-00012100": "On December 31, 2019, this document is sent for examination to Moscow State Examination Agency.", "fcmefaeSfDu-00015-00012100-00012500": "State examination", "fcmefaeSfDu-00016-00012500-00013200": "The experts thoroughly check the project documentation, provide their comments concerning the flaws that are then promptly eliminated by \"SovElMash\".", "fcmefaeSfDu-00017-00013200-00014700": "The process is greatly delayed due to the serious errors made by the general contractor and the coronavirus pandemic. However, in May 2020, the state examination agency issues a positive report, and in June, the other regulatory authorities issue their approval too.", "fcmefaeSfDu-00018-00014700-00015000": "Construction On July 15, the construction activities finally start on the site", "fcmefaeSfDu-00019-00015000-00017000": "What is to be done during the first construction stage: building a construction camp that meets all the modern requirements for workplace management, connecting all the utilities, providing the Internet access, arranging a checkpoint and a washing point for the equipment as well as the dining facilities and so on.", "fcmefaeSfDu-00020-00017000-00017400": "What will the \"SovElMash\" innovative center be like?", "fcmefaeSfDu-00021-00017400-00018400": "The building with three floors will be located on a land lot of a bit more than 2 hectares. The main part will consist of two complexes: administrative and production.", "fcmefaeSfDu-00022-00018400-00019200": "The innovative centre will provide comfortable working environment for the company's employees. It will also include a showroom and a conference hall.", "fcmefaeSfDu-00023-00019200-00019500": "The innovative center is planned to be built in 2 years.", "fcmefaeSfDu-00024-00019500-00020300": "Summing up the results, we can say that the project has hit a new milestone in its development leaving behind an extremely difficult preparatory stage.", "fcmefaeSfDu-00025-00020300-00021100": "Support the project \"Duyunov's motors\" with your investments and become the co-owner of the innovative enterprise to receive your part of the profit in the future!", "fcmefaeSfDu-00026-00021100-00022300": "Invest with maximum profit up to and including July 29 until the end of stage 13 in the project funding. From July 30, the investment shares will cost more.", "fcmefaeSfDu-00027-00022300-00023200": "The investors who supported the project at the early stages and have not yet closed their installment plans have the opportunity to increase their investment packages at the date-of-purchase discount until the end of the current stage.", "fcmefaeSfDu-00028-00023200-00023900": "I am Alexander Sudarev, subscribe to the channel, hit the like button, share this video with your friends and see you again!"}}, {"audio_id": "fcQQU_KMgT0", "text": {"fcQQU_KMgT0-00000-00001525-00001946": "One of the reasons you use any microscope is to look at fine features", "fcQQU_KMgT0-00001-00001946-00002303": "on the surface of something. here we have a small spider and you might want to", "fcQQU_KMgT0-00002-00002303-00002741": "look at details of the eyes, details of small hairs on it, and you would use an", "fcQQU_KMgT0-00003-00002741-00003215": "optical microscope where light comes down, strikes the subject, and goes up", "fcQQU_KMgT0-00004-00003215-00003632": "through the optics to your eye. so now we are going to see some of the specimen", "fcQQU_KMgT0-00005-00003632-00004127": "under the scanning electron microscope. you just saw a bug under the light", "fcQQU_KMgT0-00006-00004127-00004487": "microscope and now we are looking at another bug under the electron", "fcQQU_KMgT0-00007-00004487-00005137": "microscope. so this is how it looks like and before we do that before we take it", "fcQQU_KMgT0-00008-00005137-00005605": "under the microscope we have to make sure that the sample is ready to be", "fcQQU_KMgT0-00009-00005605-00006317": "analyzed. and for that it is very important that the sample is dry and it", "fcQQU_KMgT0-00010-00006317-00007025": "has a conductive coating and if you look at this sample here it has a coating of", "fcQQU_KMgT0-00011-00007025-00007834": "gold. gold it has small grains so it is it gets better resolution and also it is", "fcQQU_KMgT0-00012-00007834-00008354": "conductive as it is a metal. this is a biological sample so this sample would", "fcQQU_KMgT0-00013-00008354-00009071": "be containing water and before using under the SEM we have to dry it", "fcQQU_KMgT0-00014-00009071-00009500": "thanks to nanoscience instruments from where we bought our SEM they gave us", "fcQQU_KMgT0-00015-00009500-00009854": "this sample and it looks really beautiful and you're going to see this", "fcQQU_KMgT0-00016-00009854-00010420": "image under the electron microscope. so this is a stub on which we mount our", "fcQQU_KMgT0-00017-00010420-00011051": "specimen and it is gold sputtered or gold coated. the coating could be", "fcQQU_KMgT0-00018-00011051-00011564": "anywhere between 5 to 50 nano meter, a very thin coat, and that gives us a very", "fcQQU_KMgT0-00019-00011564-00012041": "good topographic resolution and magnification of the specimen that we", "fcQQU_KMgT0-00020-00012041-00012655": "are looking at. this is our sample holder and now we mount it", "fcQQU_KMgT0-00021-00013475-00014033": "once we have this. now we have to make certain that the mounted samples highest", "fcQQU_KMgT0-00022-00014033-00014911": "point is below the lip of the Phenom sample holder and then once we have that", "fcQQU_KMgT0-00023-00014911-00015533": "we have to make sure it is four more notches down so we take it even further", "fcQQU_KMgT0-00024-00015533-00015787": "down", "fcQQU_KMgT0-00025-00016316-00017203": "and now it is ready to be analyzed and we put it under the chamber.", "fcQQU_KMgT0-00026-00017769-00018334": "so we're looking at the sample of the gold covered bug in the SEM right now we", "fcQQU_KMgT0-00027-00018334-00018577": "didn't get to look at it under the light microscope but we'd take it to look at", "fcQQU_KMgT0-00028-00018577-00018991": "the spider and I gotta say this looks really cool way cooler than the spider", "fcQQU_KMgT0-00029-00018991-00019420": "did under SEM we were able to get a look at the spiders like eyes and stuff like", "fcQQU_KMgT0-00030-00019420-00019942": "that underneath the light microscope but it's not nearly as cool as this. you can", "fcQQU_KMgT0-00031-00019942-00020593": "see here we have a beautiful compound eye you can see very well under SEM and", "fcQQU_KMgT0-00032-00020593-00021376": "there's nice contrast in between all the different elemental different", "fcQQU_KMgT0-00033-00021376-00021871": "compositions in the bug and definitely I love that you can see all these tiny", "fcQQU_KMgT0-00034-00021871-00022465": "little microscopic hairs in here it's they're very cool-looking and you don't", "fcQQU_KMgT0-00035-00022465-00022767": "get to see that with the light microscope"}}, {"audio_id": "fcU-HnND_aI", "text": {}}, {"audio_id": "fdf3MlAI06U", "text": {"fdf3MlAI06U-00000-00000420-00000643": "♪ Someday I'll let you in ♪", "fdf3MlAI06U-00001-00000657-00000803": "♪ Treat you right ♪", "fdf3MlAI06U-00002-00000817-00001074": "♪ Drive you outta your mind ♪", "fdf3MlAI06U-00003-00001087-00001217": "[cheering]", "fdf3MlAI06U-00004-00001231-00001481": "♪ You never met  A chick like me ♪", "fdf3MlAI06U-00005-00001494-00001928": "♪ Burn so bright  I'm gonna make you blind ♪", "fdf3MlAI06U-00006-00001941-00002078": "♪ Always want ♪", "fdf3MlAI06U-00007-00002092-00002258": "♪ What you can't have  Is it so bad ♪", "fdf3MlAI06U-00008-00002272-00002455": "♪ If you don't get  What you wanted? ♪", "fdf3MlAI06U-00009-00002469-00002622": "♪ Make you feel good  As I whip you into shape ♪", "fdf3MlAI06U-00010-00002635-00002799": "♪ Yeah, boy  Let's get it started ♪", "fdf3MlAI06U-00011-00002812-00002972": "♪ Give it up  You can't win ♪", "fdf3MlAI06U-00012-00002986-00003176": "♪ Cause I know  Where you've been ♪", "fdf3MlAI06U-00013-00003189-00003536": "♪ Such a shame  You don't put up a fight ♪", "fdf3MlAI06U-00014-00003590-00004007": "♪ That's a game that we play  At the end of the night ♪", "fdf3MlAI06U-00015-00004020-00004407": "♪ It's the same old story  But you never get it right ♪", "fdf3MlAI06U-00016-00004421-00004531": "♪ Give it up! ♪", "fdf3MlAI06U-00017-00004544-00004821": "♪ So stop trying to walk away ♪", "fdf3MlAI06U-00018-00004834-00005195": "♪ No you won't  Ever leave me behind ♪", "fdf3MlAI06U-00019-00005208-00005558": "♪ No you better believe  That I'm here to stay ♪", "fdf3MlAI06U-00020-00005572-00005739": "♪ (That's right)  'Cause you're the shade ♪", "fdf3MlAI06U-00021-00005752-00005955": "♪ And I'm the sunshine ♪", "fdf3MlAI06U-00022-00005975-00006109": "♪ O-O-Oh ♪", "fdf3MlAI06U-00023-00006122-00006269": "♪ Look at me boy ♪", "fdf3MlAI06U-00024-00006282-00006409": "♪ 'Cause I got you  Where I want you ♪", "fdf3MlAI06U-00025-00006423-00006563": "♪ Isn't it so exciting? ♪", "fdf3MlAI06U-00026-00006576-00006763": "♪ Wanna shake you  Wanna break you ♪", "fdf3MlAI06U-00027-00006776-00006910": "♪ Take the back seat, boy  'Cause now I'm driving ♪", "fdf3MlAI06U-00028-00006923-00007113": "♪ Give it up, you can't win ♪", "fdf3MlAI06U-00029-00007127-00007297": "♪ 'Cause I know  Where you've been ♪", "fdf3MlAI06U-00030-00007310-00007670": "♪ Such a shame  You don't put up a fight ♪", "fdf3MlAI06U-00031-00007707-00008111": "♪ That's a game that we play  At the end of the night ♪", "fdf3MlAI06U-00032-00008124-00008528": "♪ It's the same old story  But you never get it right ♪", "fdf3MlAI06U-00033-00008541-00008651": "♪ Give it up ♪", "fdf3MlAI06U-00034-00008665-00008822": "♪ Come a little closer ♪", "fdf3MlAI06U-00035-00008835-00009042": "♪ Come a little closer  Baby, baby ♪", "fdf3MlAI06U-00036-00009075-00009232": "♪ Come a little closer ♪", "fdf3MlAI06U-00037-00009245-00009449": "♪ Come a little closer  Baby, baby ♪", "fdf3MlAI06U-00038-00009462-00009596": "♪ Come a little closer ♪", "fdf3MlAI06U-00039-00009609-00009793": "♪ Come a little closer, baby ♪", "fdf3MlAI06U-00040-00009806-00009946": "♪ Yeah, you are my baby ♪", "fdf3MlAI06U-00041-00009959-00010223": "♪ And I'll make you crazy  Tonight ♪", "fdf3MlAI06U-00042-00010236-00010383": "♪ Look at me boy ♪", "fdf3MlAI06U-00043-00010396-00010523": "♪ 'Cause I got you  Where I want you ♪", "fdf3MlAI06U-00044-00010537-00010677": "♪ Isn't it so exciting? ♪", "fdf3MlAI06U-00045-00010690-00010877": "♪ Wanna shake you  Wanna break you ♪", "fdf3MlAI06U-00046-00010890-00011044": "♪ Take the back seat, boy  'Cause now I'm driving ♪", "fdf3MlAI06U-00047-00011057-00011237": "♪ Give it up, you can't win ♪", "fdf3MlAI06U-00048-00011251-00011444": "♪ 'Cause I know  Where you've been ♪", "fdf3MlAI06U-00049-00011458-00011805": "♪ Such a shame  You don't put up a fight ♪", "fdf3MlAI06U-00050-00011828-00012262": "♪ That's a game that we play  At the end of the night ♪", "fdf3MlAI06U-00051-00012275-00012649": "♪ It's the same old story  But you never get it right ♪", "fdf3MlAI06U-00052-00012662-00013356": "♪ Give it up!  Oh, yeah ♪", "fdf3MlAI06U-00053-00013369-00014057": "[cheering]", "fdf3MlAI06U-00054-00014070-00014371": "[cheering]", "fdf3MlAI06U-00055-00014384-00015025": "[cheering]", "fdf3MlAI06U-00056-00015038-00015335": "Yeah, we go to school with them. That's what's up.", "fdf3MlAI06U-00057-00015348-00015815": "Yeah, yeah, baby. What about that? Right?", "fdf3MlAI06U-00058-00015829-00016052": "[cheering]", "fdf3MlAI06U-00059-00016066-00016209": "Okay, that's everybody on the list.", "fdf3MlAI06U-00060-00016222-00016463": "So now to announce tonight's Karaoke Dokie winner,", "fdf3MlAI06U-00061-00016476-00016793": "here's the owner of the joint, the man who signs my checks,", "fdf3MlAI06U-00062-00016806-00016973": "Joey Ferguson.", "fdf3MlAI06U-00063-00016986-00017370": "[cheering]", "fdf3MlAI06U-00064-00017413-00017540": "Thanks, everyone.", "fdf3MlAI06U-00065-00017554-00017754": "Lot of great singers here tonight. Huh?", "fdf3MlAI06U-00066-00017767-00017951": "[cheering]", "fdf3MlAI06U-00067-00017964-00018271": "But I think two girls really stood out.", "fdf3MlAI06U-00068-00018284-00018635": "[cheering]", "fdf3MlAI06U-00069-00018675-00019159": "So tonight's winners are... Haley and Tara!", "fdf3MlAI06U-00070-00019172-00019305": "[screaming]", "fdf3MlAI06U-00071-00019325-00019452": "Yay.", "fdf3MlAI06U-00072-00019506-00019736": "Hey, are you wazzin' me?", "fdf3MlAI06U-00073-00019823-00019913": "Rex.", "fdf3MlAI06U-00074-00019926-00020090": "Those scrunges can't sing.", "fdf3MlAI06U-00075-00020230-00020373": "Come on, man.", "fdf3MlAI06U-00076-00020387-00020533": "These girls got ten times more applause than them.", "fdf3MlAI06U-00077-00020550-00020680": "Just sit down.", "fdf3MlAI06U-00078-00020693-00020797": "I'll sit you down.", "fdf3MlAI06U-00079-00020864-00021261": "Hey, hey, I own the club. So, I decide who wins.", "fdf3MlAI06U-00080-00021297-00021434": "Thank you, Dad.", "fdf3MlAI06U-00081-00021504-00021641": "Dad?", "fdf3MlAI06U-00082-00021741-00021858": "[chuckles]", "fdf3MlAI06U-00083-00021871-00022088": "Dad!", "fdf3MlAI06U-00084-00022172-00022325": "Wait. Why would she call him dad,", "fdf3MlAI06U-00085-00022338-00022776": "unless... I bet he's her father.", "fdf3MlAI06U-00086-00022919-00023082": "Fix! Fix!", "fdf3MlAI06U-00087-00023096-00023356": "[booing]", "fdf3MlAI06U-00088-00023369-00023690": "Hey, hey! We won 'cause we rock.", "fdf3MlAI06U-00089-00023703-00023987": "Yeah, don't believe everything your daddy says.", "fdf3MlAI06U-00090-00024063-00024247": "Like when he tells you you're pretty.", "fdf3MlAI06U-00091-00024277-00024390": "[gasping]", "fdf3MlAI06U-00092-00024414-00024681": "Yeah! Testify!", "fdf3MlAI06U-00093-00024741-00024878": "Okay, that's it.", "fdf3MlAI06U-00094-00024898-00025101": "You guys are banned from singing here ever again.", "fdf3MlAI06U-00095-00025115-00025288": "Yeah, like we care.", "fdf3MlAI06U-00096-00025305-00025408": "Come on, let's get out of here.", "fdf3MlAI06U-00097-00025421-00025545": "Let's bail.", "fdf3MlAI06U-00098-00025558-00025912": "Okay, I have your nachos, your sliders", "fdf3MlAI06U-00099-00025925-00026079": "and the buffalo nuggets.", "fdf3MlAI06U-00100-00026373-00026706": "I say we get outta here... right after we finish this food.", "fdf3MlAI06U-00101-00026719-00026893": "- Right after! - Yeah.", "fdf3MlAI06U-00102-00026913-00027016": "Pass the ranch dressing.", "fdf3MlAI06U-00103-00027030-00027143": "- Here. - Ketchup!", "fdf3MlAI06U-00104-00027157-00027283": "- Comin' at ya. - Ahh.", "fdf3MlAI06U-00105-00027317-00027467": "Mm, this is delicious.", "fdf3MlAI06U-00106-00027483-00027597": "The best."}}, {"audio_id": "fdi6OX0d-dc", "text": {"fdi6OX0d-dc-00000-00000000-00000352": "the actor is immersed in this project and is looking forward to", "fdi6OX0d-dc-00001-00000352-00001592": "starting an upcoming title for disney plus turkey", "fdi6OX0d-dc-00002-00001692-00002400": "Can yaman revolutionizes italy with the shooting of his new series kanyaman's", "fdi6OX0d-dc-00003-00002400-00002904": "followers are following him and the turkish actor has captivated viewers around the world", "fdi6OX0d-dc-00004-00002904-00003640": "with titles such as dream bird now he is immersed in the filming of his new series and is in italy", "fdi6OX0d-dc-00005-00003640-00004152": "where he has revolutionized all his fandom as he passes through different italian cities", "fdi6OX0d-dc-00006-00004296-00004768": "what is ken yaman working on now the list of projects that come to the interpreter", "fdi6OX0d-dc-00007-00004768-00005536": "is so long that it is easy to lose track of him ahora mismo l actor say encuentra an italia", "fdi6OX0d-dc-00008-00005536-00006304": "grabando su nueva siri viola kamel mayer junto a su comparacop protagonista francesca kilemi", "fdi6OX0d-dc-00009-00006408-00006895": "for the last few days yaman has shared different posts on his social networks", "fdi6OX0d-dc-00010-00006895-00007376": "about his stay in italy but very few knew if it was a vacation or a new project", "fdi6OX0d-dc-00011-00007488-00008040": "thanks to the story shared by his co-star we have been able to discover that the actor is still", "fdi6OX0d-dc-00012-00008040-00008816": "recording the series for which there is still no release date in spain marmi tuscany has been one", "fdi6OX0d-dc-00013-00008816-00009368": "of the locations that has hosted the actor during his stay in the country and where the actor has", "fdi6OX0d-dc-00014-00009368-00009872": "signed autographs and has taken numerous photos with fans who were on its streets and near his", "fdi6OX0d-dc-00015-00009872-00010656": "hotel but without a doubt rimini has been the city that has revolutionized the actor the most", "fdi6OX0d-dc-00016-00010656-00011344": "and the videos shared on his instagram account are proof of this many more details are still unknown", "fdi6OX0d-dc-00017-00011344-00011848": "but what has been revealed are some behind the scenes images in the form of a poster of fiction", "fdi6OX0d-dc-00018-00012008-00012552": "the title tells the story of a young journalist who after suffering a normal problem", "fdi6OX0d-dc-00019-00012552-00012936": "her perception of certain things and reality has been modified", "fdi6OX0d-dc-00020-00012936-00014184": "in addition the protagonist will be involved in a murder whose culprit is saphir a famous singer", "fdi6OX0d-dc-00021-00014840-00014847": "you"}}, {"audio_id": "fdJ3Ql2UkNQ", "text": {"fdJ3Ql2UkNQ-00000-00000134-00000521": "Are you sick and tired of dealing with poor  flexibility", "fdJ3Ql2UkNQ-00001-00000521-00000648": "poor posture", "fdJ3Ql2UkNQ-00002-00000648-00001175": "Back problems aching joints being overweight or balanced stress", "fdJ3Ql2UkNQ-00003-00001175-00001544": "or just want to increase your sense of health and well-being", "fdJ3Ql2UkNQ-00004-00001544-00001946": "Then experience the rejuvenating power of yoga", "fdJ3Ql2UkNQ-00005-00001946-00002053": "presenting", "fdJ3Ql2UkNQ-00006-00002053-00002290": "Keep youthful with yoga", "fdJ3Ql2UkNQ-00007-00002290-00002763": "A four  dvd sets that's guaranteed to change your life for the better", "fdJ3Ql2UkNQ-00008-00002763-00003177": "Discover the little know all Natural holistic secrets that can transform", "fdJ3Ql2UkNQ-00009-00003177-00003723": "your body mind and spirit make excess weight and stress vanish like magic", "fdJ3Ql2UkNQ-00010-00003723-00003959": "without the need of pills", "fdJ3Ql2UkNQ-00011-00003959-00004115": "diets or endless jogging", "fdJ3Ql2UkNQ-00012-00004115-00004459": "It all starts with keeping youthful with yoga", "fdJ3Ql2UkNQ-00013-00004459-00004522": "grab your copy today"}}, {"audio_id": "fe7xD_CsRHQ", "text": {"fe7xD_CsRHQ-00000-00000008-00000504": "hello guys hello and welcome to koino's youtube channel how are you doing i hope", "fe7xD_CsRHQ-00001-00000504-00001008": "you're all good as you see another new video guys and today i have a special video for you", "fe7xD_CsRHQ-00002-00001096-00001800": "about the error coins of washington quarter dollar coins collection i have three error coins with the", "fe7xD_CsRHQ-00003-00001864-00002464": "mint mark error on that from the denver so now i will show you and tell you about these coins guys", "fe7xD_CsRHQ-00004-00002608-00003008": "so as you see guys i have four coins of the washington quarter", "fe7xD_CsRHQ-00005-00003008-00003847": "dollar coin so now i will show you the 1979 coin that coins made from copper nickel plated copper", "fe7xD_CsRHQ-00006-00003847-00004448": "the weight is 10 grams diameter 24 millimeter so guys let's have a look here you see here the mid", "fe7xD_CsRHQ-00007-00004448-00005216": "mark the that coin from the denver and you see the error on that coin let's have a look on the second", "fe7xD_CsRHQ-00008-00005216-00005872": "and the third coin i have i have only three coins with that mint mark errors on the coins", "fe7xD_CsRHQ-00009-00006040-00006808": "okay so watch with attention guys have a look on this errors the small dots instead of the d", "fe7xD_CsRHQ-00010-00006880-00007536": "letter i wanted to find that coins on the sale and i will show you now", "fe7xD_CsRHQ-00011-00007592-00008352": "that coins on sale three coins with that three errors the same error on that other sides", "fe7xD_CsRHQ-00012-00008528-00009224": "so let's compare it with the normal coin the 1980s quarter dollar was from denver with that", "fe7xD_CsRHQ-00013-00009224-00009992": "d mint mark as you see the normal d mint mark looks like and let's compare it with that my", "fe7xD_CsRHQ-00014-00009992-00010688": "error coins you see the difference the normal coin and the error coin from denver guys so", "fe7xD_CsRHQ-00015-00010840-00011400": "i have three of these coins there are very expensive one so let's have a look for the", "fe7xD_CsRHQ-00016-00011400-00012136": "last time for these coins three coins of copper nickel the quarter dollars of 1979", "fe7xD_CsRHQ-00017-00012136-00012784": "with the mint mark error so let's have a look on ebay to discuss how much they cost guys", "fe7xD_CsRHQ-00018-00012919-00013663": "so guys as you see we are here on ebay and i found only one coin the 1979 washington quarter with", "fe7xD_CsRHQ-00019-00013663-00014480": "the mint mark error double feeling on the d mint mark as you see that's the coin the same as i have", "fe7xD_CsRHQ-00020-00014591-00015640": "the same mint mark error guys as you see the d letter looks like a dot on the coin so you see", "fe7xD_CsRHQ-00021-00015640-00016440": "here on the right side so if you have these coins guys 150 dollars the only one coin that's", "fe7xD_CsRHQ-00022-00016440-00017368": "the rare coins guys that's why only one post in the ebay we found here i'll post my points for", "fe7xD_CsRHQ-00023-00017368-00018136": "sale for 150 dollars on my website thecoinos.com if you want guys if you are interested in buying", "fe7xD_CsRHQ-00024-00018136-00019016": "that coin you can get it on the coin ass.com you see here the mint mark error the 1979 with the d", "fe7xD_CsRHQ-00025-00019264-00020120": "letter with error so the 1979 washington quarter very rare coins and only one i found", "fe7xD_CsRHQ-00026-00020120-00020864": "for this price you can find the same name post on internet but they will be the different errors", "fe7xD_CsRHQ-00027-00020864-00021896": "not exactly this one my error points looks like these so 180 the only one post we have on internet", "fe7xD_CsRHQ-00028-00021896-00022736": "and i will post my coins for 150 dollars so guys as you saw we found only one post on internet", "fe7xD_CsRHQ-00029-00022736-00023456": "on ebay that coin for 180 dollars i have three of these coins guys and i post them for sale for one", "fe7xD_CsRHQ-00030-00023456-00024080": "hundred fifty dollars you can find them on this website thecoinos.com if you're interested in", "fe7xD_CsRHQ-00031-00024080-00024544": "i hope you like this video guys don't forget to subscribe on us and click the bell so you can", "fe7xD_CsRHQ-00032-00024544-00025048": "get all the new interesting videos in time and you can be informed about all the real prices", "fe7xD_CsRHQ-00033-00025048-00025648": "for the coins for 2021 subscribe on our youtube channel and see you in the next video guys bye"}}, {"audio_id": "feiJhS_eNCg", "text": {"feiJhS_eNCg-00000-00000302-00000462": "Hello Guys!, What is up?", "feiJhS_eNCg-00001-00000528-00000624": "How Are You Everybody", "feiJhS_eNCg-00002-00000700-00000911": "This is very short video", "feiJhS_eNCg-00003-00000940-00001019": "Just to show you", "feiJhS_eNCg-00004-00001042-00001350": "How to earn money online", "feiJhS_eNCg-00005-00001500-00001782": "Without doing a fake investment", "feiJhS_eNCg-00006-00001782-00002070": "Without getting scammed by anybody online", "feiJhS_eNCg-00007-00002232-00002424": "It is how to earn money online", "feiJhS_eNCg-00008-00002466-00002762": "From your own entity, From your own business", "feiJhS_eNCg-00009-00002762-00003010": "So this video will not take more than three minutes", "feiJhS_eNCg-00010-00003130-00003732": "My business opportunity which i am just sharing with you", "feiJhS_eNCg-00011-00003778-00004136": "Is to own your own online store", "feiJhS_eNCg-00012-00004136-00004342": "And market this online store in social media", "feiJhS_eNCg-00013-00004362-00004684": "or in the web for free or paid", "feiJhS_eNCg-00014-00004724-00005122": "Market it and make your own money", "feiJhS_eNCg-00015-00005122-00005266": "With a real business opportunity", "feiJhS_eNCg-00016-00005406-00005814": "So what i am showing to you here is just a smaple of the websites", "feiJhS_eNCg-00017-00005834-00006158": "Which you can own and manage by yourself", "feiJhS_eNCg-00018-00006182-00006656": "This is IPTV products, and this is social media products", "feiJhS_eNCg-00019-00006808-00007159": "This is teeth whitening products", "feiJhS_eNCg-00020-00007392-00007954": "This is an example fashion accessories store", "feiJhS_eNCg-00021-00008198-00008718": "And here also you can see wigs and hair extension store", "feiJhS_eNCg-00022-00009048-00009584": "Another sample diet and slimming products", "feiJhS_eNCg-00023-00009866-00010244": "And here is my sales page", "feiJhS_eNCg-00024-00010352-00010788": "So in very short this are two kind of websites", "feiJhS_eNCg-00025-00010788-00011354": "One is delivering digital products and another one delivering dropship products", "feiJhS_eNCg-00026-00011366-00011702": "You don't need to store anything in your warehouse", "feiJhS_eNCg-00027-00011842-00012280": "So digital products you will get the list of whole suppliers", "feiJhS_eNCg-00028-00012280-00012510": "With there prices to you and your selling prices", "feiJhS_eNCg-00029-00012510-00012772": "With minimum margin %50", "feiJhS_eNCg-00030-00012908-00013284": "and in physical products your margin is minimum %30-%50", "feiJhS_eNCg-00031-00013308-00013491": "and everything is dropship", "feiJhS_eNCg-00032-00013491-00013806": "So all what you need to do is to wait your customer", "feiJhS_eNCg-00033-00013806-00014290": "buy anything from your store then you get the money and order for your customer", "feiJhS_eNCg-00034-00014302-00014504": "from your dropship supplier", "feiJhS_eNCg-00035-00014504-00014978": "To be shipped directly from your supplier to your customer worldwide", "feiJhS_eNCg-00036-00015158-00015956": "This is my sales page which is incomestream.guru/my-online-business", "feiJhS_eNCg-00037-00015986-00016428": "This business opportunity by only $199", "feiJhS_eNCg-00038-00016492-00016734": "So you are getting by this $199", "feiJhS_eNCg-00039-00016754-00016922": "1- Premium domain name", "feiJhS_eNCg-00040-00016922-00017046": "2- Premium hosting", "feiJhS_eNCg-00041-00017066-00017240": "3- SSL certificate", "feiJhS_eNCg-00042-00017276-00017598": "4- Complete designed website as a store", "feiJhS_eNCg-00043-00017680-00018208": "5- 200 to 500 products ready added to your store", "feiJhS_eNCg-00044-00018218-00018402": "6- The list of the suppliers", "feiJhS_eNCg-00045-00018402-00018662": "7- You will get your cost , you will get your selling price", "feiJhS_eNCg-00046-00018662-00018910": "And you will get training at least for one hour", "feiJhS_eNCg-00047-00018910-00019070": "over skype to show you", "feiJhS_eNCg-00048-00019094-00019364": "how to manage your own online business", "feiJhS_eNCg-00049-00019400-00019828": "and how to earn money online without getting any scam", "feiJhS_eNCg-00050-00019828-00020202": "You just need to buy your website and to manage your website by yourself", "feiJhS_eNCg-00051-00020236-00020634": "And you don't need to follow any scam or spam online", "feiJhS_eNCg-00052-00020634-00021478": "On the top of that you will get some ebook to give away to your website visitors", "feiJhS_eNCg-00053-00021482-00021764": "I will help you to link your website to adsense", "feiJhS_eNCg-00054-00021764-00022106": "I will help you to link your website to google analytics", "feiJhS_eNCg-00055-00022130-00022586": "You will get everything ready even if you don't know anything before", "feiJhS_eNCg-00056-00022586-00022934": "Don't worry , it si our job to make it very easy for you", "feiJhS_eNCg-00057-00023328-00023504": "The link for this sale page", "feiJhS_eNCg-00058-00023530-00023696": "will be in description", "feiJhS_eNCg-00059-00023756-00023948": "And all details will be there", "feiJhS_eNCg-00060-00024000-00024576": "If you go to any agency to design your own website it will cost you minimum $2000 to $3000", "feiJhS_eNCg-00061-00024576-00024874": "But here you are getting everything in one package", "feiJhS_eNCg-00062-00024900-00025426": "Just your own website, you are the lonely owner of this website", "feiJhS_eNCg-00063-00025462-00025898": "Which you can manage by yourself and you will be your own boss", "feiJhS_eNCg-00064-00025898-00026108": "You don't need to work for anybody", "feiJhS_eNCg-00065-00026108-00026239": "You don't need to sell any affiliate products", "feiJhS_eNCg-00066-00026239-00026436": "You don't need to sell any clickbank products", "feiJhS_eNCg-00067-00026436-00026610": "You don't need to do anything !!!", "feiJhS_eNCg-00068-00026610-00026776": "Just work for your website", "feiJhS_eNCg-00069-00026808-00027133": "Very hard and you will find out that after", "feiJhS_eNCg-00070-00027170-00027270": "5 to 6 weeks", "feiJhS_eNCg-00071-00027302-00027770": "minimum you will start making $200-$500-$1000 a week", "feiJhS_eNCg-00072-00027820-00027910": "Good Luck Guys", "feiJhS_eNCg-00073-00027927-00028094": "This is my business opportunity", "feiJhS_eNCg-00074-00028106-00028282": "which i am sharing with you", "feiJhS_eNCg-00075-00028282-00028402": "Please check the link in description", "feiJhS_eNCg-00076-00028402-00028452": "Thank You"}}, {"audio_id": "fexE79bA6Q4", "text": {"fexE79bA6Q4-00000-00000208-00000626": "I'm Courtney Maiorino and I was diagnosed with Crohn's Disease in 2012.", "fexE79bA6Q4-00001-00000626-00001054": "Upon diagnosis, I was put on immunosuppressants and steroids.", "fexE79bA6Q4-00002-00001054-00001407": "I've also been on biologic infusion medications also.", "fexE79bA6Q4-00003-00001408-00002051": "The immunosuppressants I had been on from 2012 until 2018,", "fexE79bA6Q4-00004-00002106-00002452": "gave me a drug-induced liver injury", "fexE79bA6Q4-00005-00002492-00002735": "and they wanted me to try a different medication.", "fexE79bA6Q4-00006-00002735-00002941": "It was the last medication that I was on.", "fexE79bA6Q4-00007-00002941-00003452": "I have been on meds since 2012 and I was finally this close to the goal", "fexE79bA6Q4-00008-00003452-00003795": "that I've had since then of being med-free and they were like,", "fexE79bA6Q4-00009-00003795-00003998": "\"We want to try you on something else,\"", "fexE79bA6Q4-00010-00003998-00004248": "and I was like, \"No.\"", "fexE79bA6Q4-00011-00004354-00004665": "To sit there in front of people who are well-intentioned,", "fexE79bA6Q4-00012-00004665-00004947": "and who are well-educated and knowledgeable, and", "fexE79bA6Q4-00013-00004948-00005240": "they only want what's best, to tell them, \"No,\"", "fexE79bA6Q4-00014-00005240-00005553": "this is a battle for me every single day", "fexE79bA6Q4-00015-00005553-00005830": "that I have in my head. Am I doing the right thing?", "fexE79bA6Q4-00016-00005830-00006274": "And so when I told them that I wasn't going on any more meds", "fexE79bA6Q4-00017-00006274-00006669": "and that I was going to trust my gut on this one,", "fexE79bA6Q4-00018-00006669-00007005": "I mean, I got into my car after my appointment and I started crying.", "fexE79bA6Q4-00019-00007005-00007427": "It was huge, it's huge and it's scary every single day", "fexE79bA6Q4-00020-00007428-00007617": "to not have a backup,", "fexE79bA6Q4-00021-00007617-00008048": "but it's also like I couldn't come out of that appointment", "fexE79bA6Q4-00022-00008048-00008517": "knowing that I had a chance to try it, and not try.", "fexE79bA6Q4-00023-00008517-00008874": "And so, so far we're good. I feel great.", "fexE79bA6Q4-00024-00008875-00008992": "I'm on no meds.", "fexE79bA6Q4-00025-00009002-00009507": "As long as I think I continue on this path of both maintenance in what I'm currently doing", "fexE79bA6Q4-00026-00009507-00009991": "and continued exploration in other avenues and things that could potentially be healing for me,", "fexE79bA6Q4-00027-00009992-00010132": "I think it's going to stay that way."}}, {"audio_id": "feB_woELxMU", "text": {"feB_woELxMU-00000-00000677-00000844": "Work package three which", "feB_woELxMU-00001-00000844-00000953": "on the face of it", "feB_woELxMU-00002-00000986-00001071": "looks like a highly technical", "feB_woELxMU-00003-00001071-00001361": "even statistical work package", "feB_woELxMU-00004-00001383-00001512": "actually is going to benefit", "feB_woELxMU-00005-00001512-00001721": "more than any other work package", "feB_woELxMU-00006-00001721-00002147": "from the input and the participation", "feB_woELxMU-00007-00002147-00002294": "of persons representing", "feB_woELxMU-00008-00002294-00002497": "all areas of disability", "feB_woELxMU-00009-00002497-00002847": "because we have to", "feB_woELxMU-00010-00002847-00003099": "learn from the experiences", "feB_woELxMU-00011-00003099-00003199": "that they’ve had", "feB_woELxMU-00012-00003199-00003368": "being denied citizenship", "feB_woELxMU-00013-00003368-00003502": "in various domains", "feB_woELxMU-00014-00003502-00003797": "and being inactive citizens", "feB_woELxMU-00015-00003797-00003984": "or simply not being citizens at all", "feB_woELxMU-00016-00003984-00004134": "We have to learn from their experience", "feB_woELxMU-00017-00004134-00004401": "what it is that from their point of view", "feB_woELxMU-00018-00004401-00004717": "is saliently measurable", "feB_woELxMU-00019-00004717-00004986": "what it is that shows that progress", "feB_woELxMU-00020-00004986-00005251": "has been made in achieving citizenship", "feB_woELxMU-00021-00005251-00005446": "Perhaps the notion of measurement", "feB_woELxMU-00022-00005446-00005705": "seems a bit too scientific", "feB_woELxMU-00023-00005705-00005830": "to be relevant in this area", "feB_woELxMU-00024-00005830-00006015": "but I can assure you", "feB_woELxMU-00025-00006015-00006161": "that without that kind of achievement", "feB_woELxMU-00026-00006161-00006423": "governments can always say", "feB_woELxMU-00027-00006423-00006601": "“well we’ve done all we need to do", "feB_woELxMU-00028-00006601-00006770": "show us that we have not”", "feB_woELxMU-00029-00006770-00006957": "And without the information", "feB_woELxMU-00030-00006957-00007090": "there’s no way to show", "feB_woELxMU-00031-00007090-00007233": "that there has been progress", "feB_woELxMU-00032-00007233-00007422": "or there hasn’t been progress", "feB_woELxMU-00033-00007422-00007681": "If changes are recommended and implemented", "feB_woELxMU-00034-00007681-00007918": "it is possible not merely to say", "feB_woELxMU-00035-00007918-00008106": "“well we’ve done that”", "feB_woELxMU-00036-00008106-00008411": "but also now we can show that", "feB_woELxMU-00037-00008411-00008510": "“we’ve done that”", "feB_woELxMU-00038-00008510-00008666": "Now we have evidence", "feB_woELxMU-00039-00008666-00008933": "and very hard statistical evidence", "feB_woELxMU-00040-00008933-00009200": "that’s quantifiable evidence", "feB_woELxMU-00041-00009200-00009486": "that shows that progress has been made", "feB_woELxMU-00042-00009486-00009688": "Now in order to do that", "feB_woELxMU-00043-00009688-00009864": "it is an extreme challenge", "feB_woELxMU-00044-00009864-00010292": "to go beyond what are usually used in this area", "feB_woELxMU-00045-00010291-00010552": "which is to say economic indicators", "feB_woELxMU-00046-00010551-00010928": "to look at indicators that measure participation", "feB_woELxMU-00047-00010928-00011196": "social participation, of the sort", "feB_woELxMU-00048-00011195-00011678": "that active citizenship is composed of", "feB_woELxMU-00049-00011677-00011877": "Those indicators,", "feB_woELxMU-00050-00011877-00012164": "those indicators are of extreme importance", "feB_woELxMU-00051-00012164-00012679": "because they allow us to make sense", "feB_woELxMU-00052-00012679-00012869": "of what it is to be a citizen", "feB_woELxMU-00053-00012869-00013047": "to respect rights and", "feB_woELxMU-00054-00013047-00013307": "also to respect them in a way that has", "feB_woELxMU-00055-00013306-00013616": "if you like, actual impact on people’s lives", "feB_woELxMU-00056-00013616-00013891": "So work package three is", "feB_woELxMU-00057-00013892-00014280": "if you like, a way of keeping governments honest", "feB_woELxMU-00058-00014321-00014727": "The case of cognitive impairments and psychosocial difficulties", "feB_woELxMU-00059-00014726-00014922": "mental health problems is always", "feB_woELxMU-00060-00014921-00015197": "perhaps unfortunately", "feB_woELxMU-00061-00015198-00015533": "a special case in the arena of disability", "feB_woELxMU-00062-00015532-00015854": "It’s very easy to marginalize these individuals", "feB_woELxMU-00063-00015853-00016231": "and put them outside of the realm of active citizenship", "feB_woELxMU-00064-00016231-00016486": "So for these individuals in particular", "feB_woELxMU-00065-00016485-00016734": "active citizenship is not only a challenge", "feB_woELxMU-00066-00016733-00016914": "but an absolute priority", "feB_woELxMU-00067-00016913-00017269": "and from the point of view of work package three", "feB_woELxMU-00068-00017269-00017517": "it is going to be an interesting challenge", "feB_woELxMU-00069-00017517-00017840": "one that hasn’t actually been addressed before", "feB_woELxMU-00070-00017839-00018224": "My own personal experience in this area has been", "feB_woELxMU-00071-00018223-00018469": "years ago, as a human rights lawyer", "feB_woELxMU-00072-00018469-00018892": "always making arguments before courts and tribunals", "feB_woELxMU-00073-00018891-00019297": "to the fact that a particular individual has been denied", "feB_woELxMU-00074-00019296-00019486": "as we would say, active citizenship", "feB_woELxMU-00075-00019486-00019720": "participation in certain kind of area", "feB_woELxMU-00076-00019720-00020000": "and then if you like, winning the case", "feB_woELxMU-00077-00020000-00020308": "walking away and never really realizing", "feB_woELxMU-00078-00020307-00020747": "or having any good faith that change will happen", "feB_woELxMU-00079-00020746-00021157": "Change happens only, it seems to me", "feB_woELxMU-00080-00021157-00021385": "if you can point to change", "feB_woELxMU-00081-00021384-00021655": "and if you can measure change over time", "feB_woELxMU-00082-00021655-00021983": "Other than that it is, as I say", "feB_woELxMU-00083-00021983-00022230": "political rhetoric, which is not a bad thing", "feB_woELxMU-00084-00022229-00022572": "but it is not enough to change people’s lives"}}, {"audio_id": "ffryw4Rq9vY", "text": {"ffryw4Rq9vY-00000-00000000-00000200": "ттутутутутутутутутутутутутутутутутутутутутутутутутутуутутуттуттуутутуттутутутутуттту"}}, {"audio_id": "ffsC2KLUC2M", "text": {"ffsC2KLUC2M-00000-00000000-00000337": "THE USS RONALD REAGAN AND RELIGIOUS MINISTRIES", "ffsC2KLUC2M-00001-00000337-00000590": "DEPARTMENT SPONSORED AN ENGLISH CLASS FOR JAPANESE", "ffsC2KLUC2M-00002-00000590-00000837": "MARITIME SELF-DEFENSE FORCE SAILORS FROM THEIR", "ffsC2KLUC2M-00003-00000837-00000990": "SISTER SHIP, JS IZUMO.", "ffsC2KLUC2M-00004-00000990-00001378": "THE FOCUS OF THE CLASS WAS TO ASSIST THE JAPANESE", "ffsC2KLUC2M-00005-00001378-00001735": "SAILORS TO INTRODUCE THEMSELVES IN ENGLISH.", "ffsC2KLUC2M-00006-00001735-00001918": "REAGAN SAILORS HELPED THEM SKETCH OUT WHAT THEY", "ffsC2KLUC2M-00007-00001918-00002305": "WANTED TO SAY AND BRIEF THEM ON THE PRONUNCIATION", "ffsC2KLUC2M-00008-00002305-00002532": "AND FORMATION OF THE WORDS.", "ffsC2KLUC2M-00009-00002532-00002846": "THEN, THE JAPANESE SAILORS INTRODUCED THEMSELVES IN", "ffsC2KLUC2M-00010-00002846-00002922": "ENGLISH.", "ffsC2KLUC2M-00011-00002922-00003026": "- THEY BEGAN A FRIENDSHIP.", "ffsC2KLUC2M-00012-00003026-00003313": "FRIENDSHIP IS BEING COMFORTABLE WITH EACH", "ffsC2KLUC2M-00013-00003313-00003563": "OTHER, AND BEING ABLE TO LOOK AT THE OTHER AND", "ffsC2KLUC2M-00014-00003563-00003653": "BUILD THIS TRUST.", "ffsC2KLUC2M-00015-00003653-00003833": "AND I THINK THEY ALREADY BEGAN THAT.", "ffsC2KLUC2M-00016-00003833-00004117": "TO SEE EXCITEMENT ON BOTH SIDES OF THE TABLE AND THE", "ffsC2KLUC2M-00017-00004117-00004327": "DESIRE NOT EVEN TO LEAVE AT THE END OF THAT HOUR,", "ffsC2KLUC2M-00018-00004327-00004571": "I THOUGHT WAS VERY INSPIRATIONAL AND IT", "ffsC2KLUC2M-00019-00004571-00004754": "REALLY HAS GIVEN US SOMETHING TO MOVE FORWARD", "ffsC2KLUC2M-00020-00004754-00005008": "WITH FOR THE NEXT FOUR CLASSES.", "ffsC2KLUC2M-00021-00005008-00005268": "FOR USS RONALD REAGAN, I'M SEAMAN TYLER JOHN."}}, {"audio_id": "ffC6KEfcHxu", "text": {"ffC6KEfcHxu-00000-00000000-00000200": "Hi, it's Yosuke Awata.", "ffC6KEfcHxu-00001-00000200-00000574": "I used to believe ideas were in my head,", "ffC6KEfcHxu-00002-00000574-00000860": "so as much ideas as I came up,", "ffC6KEfcHxu-00003-00000860-00001098": "I would run out of ideas.", "ffC6KEfcHxu-00004-00001098-00001407": "But since I have painted a lot,", "ffC6KEfcHxu-00005-00001407-00001906": "I realized more I come up, I would get more ideas.", "ffC6KEfcHxu-00006-00001906-00002244": "Brain gets momentum.", "ffC6KEfcHxu-00007-00002639-00002965": "I bought this loose leaf.", "ffC6KEfcHxu-00008-00002965-00003453": "Paper come out, and I can put new paper.", "ffC6KEfcHxu-00009-00003453-00003880": "There were 10 sheets, and I drew with this pan.", "ffC6KEfcHxu-00010-00003880-00004486": "Easy drawing like this can be good exercise for coming up ideas.", "ffC6KEfcHxu-00011-00004486-00005219": "I'd like to do sketchbook tour and talk about ideas.", "ffC6KEfcHxu-00012-00005838-00006217": "First page, I felt like drawing a lobster.", "ffC6KEfcHxu-00013-00006217-00006548": "I didn't have any other ideas at first.", "ffC6KEfcHxu-00014-00006548-00006754": "once I started drawing,", "ffC6KEfcHxu-00015-00006754-00007191": "the shapes I created remind me different objects.", "ffC6KEfcHxu-00016-00007721-00008036": "Next page, I drew vertical.", "ffC6KEfcHxu-00017-00008157-00008389": "I drew this bottle at first,", "ffC6KEfcHxu-00018-00008389-00008603": "and I drew the flower.", "ffC6KEfcHxu-00019-00008603-00008959": "I come up after I draw something.", "ffC6KEfcHxu-00020-00008959-00009216": "I create some stories,", "ffC6KEfcHxu-00021-00009216-00009588": "but I make them unclear.", "ffC6KEfcHxu-00022-00009588-00009916": "I drew after midnight and was tired,", "ffC6KEfcHxu-00023-00009916-00010116": "so I stoped like this.", "ffC6KEfcHxu-00024-00010116-00010546": "I don't get much ideas when I'm tired.", "ffC6KEfcHxu-00025-00010546-00010953": "Next day, I added stars and things to finish.", "ffC6KEfcHxu-00026-00010953-00011112": "Next page,", "ffC6KEfcHxu-00027-00011112-00011759": "I just wanted something around a circle negative space,", "ffC6KEfcHxu-00028-00011759-00012105": "I began to create this shapes,", "ffC6KEfcHxu-00029-00012105-00012470": "I thought it would be neat if I drew several of them.", "ffC6KEfcHxu-00030-00012470-00012707": "so I drew like this.", "ffC6KEfcHxu-00031-00013065-00013454": "Next page is a little weird picture of cats", "ffC6KEfcHxu-00032-00013454-00013824": "It's rough because I was tired.", "ffC6KEfcHxu-00033-00013824-00014479": "It was good practice because I though about interesting shapes", "ffC6KEfcHxu-00034-00014479-00014954": "composition, or position of this polka. dots.", "ffC6KEfcHxu-00035-00014954-00015355": "Next page is a cat drawing again.", "ffC6KEfcHxu-00036-00015355-00015639": "I started from this mouth.", "ffC6KEfcHxu-00037-00015639-00015996": "I start drawing differently each time,", "ffC6KEfcHxu-00038-00015996-00016372": "so I come up different ideas every time.", "ffC6KEfcHxu-00039-00016372-00017074": "even with short time, simple drawing help me to come up ideas.", "ffC6KEfcHxu-00040-00017074-00017825": "These were simple drawing, but it's a little complicated drawing.", "ffC6KEfcHxu-00041-00017825-00018126": "I creates a birds in this shape.", "ffC6KEfcHxu-00042-00018126-00018388": "I draw another one and eggs,", "ffC6KEfcHxu-00043-00018388-00018674": "and the pattern reminds of tears.", "ffC6KEfcHxu-00044-00018674-00019125": "Well, that's how I come uo my ideas.", "ffC6KEfcHxu-00045-00019553-00019720": "Next page,", "ffC6KEfcHxu-00046-00019720-00020101": "I drew this glass first.", "ffC6KEfcHxu-00047-00020101-00020489": "I imagined what could be next to it.", "ffC6KEfcHxu-00048-00020489-00020749": "then I drew these shape", "ffC6KEfcHxu-00049-00020749-00021187": "all shapes associate each other.", "ffC6KEfcHxu-00050-00021548-00021944": "Next page, let's see the sequence.", "ffC6KEfcHxu-00051-00021944-00022370": "I saw cat comb before I drew,", "ffC6KEfcHxu-00052-00022370-00022669": "I started drawing shape like a comb.", "ffC6KEfcHxu-00053-00027590-00028103": "I drew like this, and it took me about 15 mins.", "ffC6KEfcHxu-00054-00028103-00028363": "I had no plans what  to draw.", "ffC6KEfcHxu-00055-00028363-00028867": "but once I start drawing, ideas kept coming up", "ffC6KEfcHxu-00056-00028867-00029196": "next to next.", "ffC6KEfcHxu-00057-00029196-00029522": "ideas come out each moments.", "ffC6KEfcHxu-00058-00029522-00030023": "I drew three pages, and here is another one.", "ffC6KEfcHxu-00059-00035368-00035715": "First I didn't think much,", "ffC6KEfcHxu-00060-00035715-00036028": "but middle of drawing,", "ffC6KEfcHxu-00061-00036028-00036457": "create eye contact to look like it has stories.", "ffC6KEfcHxu-00062-00036541-00036781": "There is one more page.", "ffC6KEfcHxu-00063-00036781-00037065": "It's simple vertical one.", "ffC6KEfcHxu-00064-00041012-00041225": "This style of face,", "ffC6KEfcHxu-00065-00041225-00041626": "I drew similar style on other page.", "ffC6KEfcHxu-00066-00041626-00041903": "I thought it was interesting", "ffC6KEfcHxu-00067-00041903-00042218": "so I used the idea here.", "ffC6KEfcHxu-00068-00042218-00042634": "If it has colors, it'll look different", "ffC6KEfcHxu-00069-00042634-00043322": "it's white so this part blending naturally and is nice.", "ffC6KEfcHxu-00070-00043322-00043646": "I kid wanna paint colored one like this,", "ffC6KEfcHxu-00071-00043646-00044146": "If it has colors, one of eyes is a ear", "ffC6KEfcHxu-00072-00044146-00044717": "If these were colors, these parts look more clear.", "ffC6KEfcHxu-00073-00044717-00045220": "but black and white works very well.", "ffC6KEfcHxu-00074-00045220-00045754": "Well, colors can be nice too, but black and white is fun!", "ffC6KEfcHxu-00075-00045754-00046224": "Drawing like this is good practice for coming up ideas.", "ffC6KEfcHxu-00076-00046596-00046978": "I used the same idea on other drawing.", "ffC6KEfcHxu-00077-00046978-00047397": "I use same ideas on different drawings.", "ffC6KEfcHxu-00078-00047397-00047799": "Keep drawing helps idea come up easily.", "ffC6KEfcHxu-00079-00047799-00048091": "Well, I drew on 10 sheets.", "ffC6KEfcHxu-00080-00048091-00048432": "I have 50 more sheets,", "ffC6KEfcHxu-00081-00048432-00048772": "so I'll draw sometimes!", "ffC6KEfcHxu-00082-00048772-00049365": "I use some of these ideas in painting in future.", "ffC6KEfcHxu-00083-00049365-00049988": "I used to think I loose all ideas in future", "ffC6KEfcHxu-00084-00049988-00050351": "if I kept coming up some.", "ffC6KEfcHxu-00085-00050351-00050786": "But once I know Ideas won't tun out.", "ffC6KEfcHxu-00086-00050786-00051130": "I use ideas immediately once I have.", "ffC6KEfcHxu-00087-00051130-00051363": "like create artworks.", "ffC6KEfcHxu-00088-00051363-00051660": "When I will need new ideas,", "ffC6KEfcHxu-00089-00051660-00052147": "I will get a new better idea!", "ffC6KEfcHxu-00090-00052147-00052615": "So I recommend simple drawing", "ffC6KEfcHxu-00091-00052615-00053351": "for practicing for coming up a lot of ideas.", "ffC6KEfcHxu-00092-00053351-00053599": "Well that is it for today.", "ffC6KEfcHxu-00093-00053599-00054207": "air you like this video, please consider subscribing", "ffC6KEfcHxu-00094-00054207-00054475": "Thank you for watching!", "ffC6KEfcHxu-00095-00054475-00054779": "See you next time! Bye bye!!"}}, {"audio_id": "ffMukGxH6lo", "text": {"ffMukGxH6lo-00000-00000540-00001028": "D: This submission seems to be about a heavy subject", "ffMukGxH6lo-00001-00001028-00001503": "D: It's says,\"I'm in need of fair judging ASAP.\"", "ffMukGxH6lo-00002-00001503-00001893": "From Mr. Kwon in Korea", "ffMukGxH6lo-00003-00001893-00002121": "Let's dig in", "ffMukGxH6lo-00004-00002121-00002291": "\"I did not elo boost!", "ffMukGxH6lo-00005-00002291-00002506": "I'm currently ranked on Gold", "ffMukGxH6lo-00006-00002506-00002745": "A player on enemy team must have joked about him being ranked on higher tier", "ffMukGxH6lo-00007-00002745-00002955": "So as soon as the match started, enemy team typed", "ffMukGxH6lo-00008-00002955-00003238": "\"TF on my team is ranked on Diamond. Gj for you guys\"", "ffMukGxH6lo-00009-00003238-00003764": "This promptly led to everyone meming", "ffMukGxH6lo-00010-00003764-00004093": "Xin Zhao said \"I'm in fact on Master tier\"", "ffMukGxH6lo-00011-00004093-00004516": "Lulu went \"I'm actually on Silver. I came to scout ranked tier Gold and so far it's disappointing\"", "ffMukGxH6lo-00012-00004516-00004892": "Thresh was like \"My friend is sitting right next to me and he's on Challenger. Good luck\"", "ffMukGxH6lo-00013-00004892-00005587": "I couldn't help but participate so I went on to type", "ffMukGxH6lo-00014-00005587-00005835": "\"GG I'm elo boosting from Bronze\"", "ffMukGxH6lo-00015-00005835-00006424": "We had a good laugh, even won the match and I simply forgot about it", "ffMukGxH6lo-00016-00006424-00007117": "But then when I logged in the next day, I was banned for a month due to elo boosting", "ffMukGxH6lo-00017-00007117-00007706": "This is so unfair. I never elo boosted. I was just joking around", "ffMukGxH6lo-00018-00007706-00008292": "Help me, judges!\"", "ffMukGxH6lo-00019-00008292-00008622": "C: Well Mr. Kwon did make a mistake", "ffMukGxH6lo-00020-00008622-00009205": "He was the only one joking about elo boosting", "ffMukGxH6lo-00021-00009205-00010016": "D: True. Other people were joking about how someone on the team was ranked on Diamond..", "ffMukGxH6lo-00022-00010016-00010259": "C: And it's okay to have secondary accounts", "ffMukGxH6lo-00023-00010259-00010778": "D: It also doesn't violate any rules to have a friend on Master tier sitting next to you", "ffMukGxH6lo-00024-00010778-00011462": "But elo boosting? it's a completely different matter...", "ffMukGxH6lo-00025-00011462-00011690": "C: The joke went too far", "ffMukGxH6lo-00026-00011690-00012070": "C: Riot should take spontaneous confessions like this seriously", "ffMukGxH6lo-00027-00012070-00012607": "D: If a guy walks into a police station and yells \"I stole something!\"", "ffMukGxH6lo-00028-00012607-00012974": "Police need to look into it and apprehend the guy", "ffMukGxH6lo-00029-00012974-00013163": "C: Yup. It had to be done", "ffMukGxH6lo-00030-00013163-00014097": "I understand how ridiculous the situation is, but Riot did what they needed to do", "ffMukGxH6lo-00031-00014097-00014277": "D: True", "ffMukGxH6lo-00032-00014277-00014858": "C: We joke a lot about elo boosting and scripting", "ffMukGxH6lo-00033-00014858-00015566": "But it's not something to make light of from Riot's perspective", "ffMukGxH6lo-00034-00015566-00015810": "D: True", "ffMukGxH6lo-00035-00015810-00016651": "C: Elo boosting is a serious issue. The process of punishment should also be swift and strict", "ffMukGxH6lo-00036-00016651-00016901": "D: It actively harms users", "ffMukGxH6lo-00037-00016901-00018150": "C: As the host of LCK, my stance on elo boosting is also no tolerance, even if it's only mentioned as a joke", "ffMukGxH6lo-00038-00018150-00018454": "D: Just be careful from next time", "ffMukGxH6lo-00039-00018454-00018859": "C: Reflect on your actions while you're banned", "ffMukGxH6lo-00040-00018859-00019097": "Don't do it from next time", "ffMukGxH6lo-00041-00019097-00019791": "D: Yup. Elo boosting is seriously wrong and it should be considered as such", "ffMukGxH6lo-00042-00019791-00020111": "ALL: D.C X-File!"}}, {"audio_id": "ffZK78HNBU8", "text": {"ffZK78HNBU8-00000-00000360-00001088": "shalom and welcome to via israel a hebrew phrase which means you shall love israel we hope you'll", "ffZK78HNBU8-00001-00001088-00001560": "stay with us for the next 30 minutes as our teacher dr baruch shares his expository teaching", "ffZK78HNBU8-00002-00001560-00002152": "from the bible dr baruch is the senior lecturer at the zera avraham institute based in israel", "ffZK78HNBU8-00003-00002152-00002616": "although all courses are taught in hebrew at the institute dr baruch is pleased to share this", "ffZK78HNBU8-00004-00002616-00003176": "weekly address in english to find out more about our work in israel please visit us on the web", "ffZK78HNBU8-00005-00003176-00003992": "at love israel.org that's one word loveisreal.org now here's baruch with today's lesson", "ffZK78HNBU8-00006-00004200-00004992": "one of the reasons that a person comes to faith in the messiah that is that he accepts the gospel", "ffZK78HNBU8-00007-00005056-00005944": "is because he wants to do the right thing and when a person knows what the right thing is and has no", "ffZK78HNBU8-00008-00005944-00006872": "intention of doing it no desire to obey the truth of god then that person is not part of the family", "ffZK78HNBU8-00009-00006872-00007688": "of god now we all struggle with doing the right thing there is temptation there is weakness but", "ffZK78HNBU8-00010-00007759-00008720": "a true believer having been redeemed by the grace of god through faith in the all-sufficient work of", "ffZK78HNBU8-00011-00008720-00009552": "messiah yeshua that is jesus christ upon that cross when a person comes to faith he desires to", "ffZK78HNBU8-00012-00009616-00010496": "be pleasing to god and again if one has no such desire but only want the benefits of god but not", "ffZK78HNBU8-00013-00010560-00011480": "fulfilling the responsibility that god has given to us in his word that person is a false believer", "ffZK78HNBU8-00014-00011544-00012232": "why do i say that well take out your bible and look with me to the book of matthew and chapter", "ffZK78HNBU8-00015-00012232-00013224": "21 the book of matthew and chapter 21 now here messiah he has been interacting with the leaders", "ffZK78HNBU8-00016-00013224-00013919": "of israel a portion of them he has discussed certain things there has been conflict and now", "ffZK78HNBU8-00017-00013984-00014719": "once again he is going to share with them a parable and frequently i pointed out a parable", "ffZK78HNBU8-00018-00014808-00015760": "from the hebrew language that word parable means a teaching that is derived from that word parable", "ffZK78HNBU8-00019-00015760-00016456": "is derived from the word for government that which rules over authority", "ffZK78HNBU8-00020-00016528-00017200": "and what we see here in the parables of messiah is truth from god that should rule our life", "ffZK78HNBU8-00021-00017272-00017952": "that we need to understand here are words of authority that we need to demonstrate and", "ffZK78HNBU8-00022-00017952-00018760": "implement into our life so let's begin matthew chapter 21 and we're going to begin in verse 33", "ffZK78HNBU8-00023-00018840-00019864": "another parable you hear and once again messiah is speaking he's addressing a crowd but primarily and", "ffZK78HNBU8-00024-00019864-00020648": "we'll see this at the end of our study primarily this parable is for leaders the leaders of israel", "ffZK78HNBU8-00025-00020720-00021656": "all of them know those who have taken a wrong position those who have set themselves against", "ffZK78HNBU8-00026-00021656-00022664": "the truth of god against his purposes and this word for here when he says you hear he is desiring", "ffZK78HNBU8-00027-00022664-00023552": "a change for them a proper response and here's a biblical truth when we hear the word of god", "ffZK78HNBU8-00028-00023624-00024440": "that truth should bring about change in our life we should constantly be conforming more and more", "ffZK78HNBU8-00029-00024440-00025320": "to the will of god that is what growth maturity growing spiritually is all about so we read here", "ffZK78HNBU8-00030-00025384-00026408": "another parable you hear and now the parable a certain man was and the next word means to be", "ffZK78HNBU8-00031-00026408-00027464": "a lord over a master of an owner of an estate so this man has authority and he has", "ffZK78HNBU8-00032-00027464-00028408": "some assets much assets he is a ruler and notice what he does he plants a vineyard", "ffZK78HNBU8-00033-00028495-00029824": "and a fence he sets around it he digs in it a wine vat and also he built a tower and then finally it", "ffZK78HNBU8-00034-00029824-00030832": "says and he leased it to vineyard owners and he departed now this word for departed means", "ffZK78HNBU8-00035-00030895-00031664": "he went on a journey and most scholars see that this word implies that he went a great", "ffZK78HNBU8-00036-00031664-00032560": "distance and it's obvious he put everything in action he built this vineyard he supplied it well", "ffZK78HNBU8-00037-00032560-00033480": "and then he leased it out too and pay attention this individuals who were vineyard workers he", "ffZK78HNBU8-00038-00033480-00034216": "chose right people based upon their qualifications their their talents their history their profession", "ffZK78HNBU8-00039-00034280-00035184": "this was fitting so it's not a problem his choice but these vineyard workers they were not men", "ffZK78HNBU8-00040-00035280-00036184": "of of honesty they were not upright they did not submit to their obligations see a person", "ffZK78HNBU8-00041-00036240-00037040": "who is a true believer that person wants to be faithful now faith involves many things but", "ffZK78HNBU8-00042-00037040-00038112": "one aspect of faith is desiring faith will cause us to desire to want to be a person of loyalty", "ffZK78HNBU8-00043-00038176-00039032": "one that is trustworthy one that speaks and acts according to his words but these", "ffZK78HNBU8-00044-00039032-00039816": "individuals they did not we're going to see that these were faithless vineyard workers", "ffZK78HNBU8-00045-00039888-00040952": "verse 34 but when the season of the fruits meaning harvest time when the season or the time", "ffZK78HNBU8-00046-00040952-00041776": "of the fruits arrived this this master of the estate we read that he sent his servants to", "ffZK78HNBU8-00047-00041840-00042512": "the vineyard workers why well remember there was an agreement he leased out this vineyard", "ffZK78HNBU8-00048-00042592-00043192": "they they would work his vineyard and obviously at the time of the harvest", "ffZK78HNBU8-00049-00043256-00044168": "they would share the the proceeds from the fruits that were produced so it says he said middle verse", "ffZK78HNBU8-00050-00044168-00045024": "34 he sent his servants to the vineyard workers to receive his fruits but notice what happened", "ffZK78HNBU8-00051-00045096-00046064": "instead of fulfilling the agreement being people who were upright those who made an agreement and", "ffZK78HNBU8-00052-00046064-00046808": "honored that agreement instead of that we read in the end of verse or the beginning of verse 35", "ffZK78HNBU8-00053-00046992-00047784": "and after taking who's this these vineyard workers after taking his servants we read", "ffZK78HNBU8-00054-00047784-00048832": "that that one they beat but another they killed and still another they stoned now think of this", "ffZK78HNBU8-00055-00048944-00049904": "these individuals they had made an agreement they got the ability in order to serve the master and", "ffZK78HNBU8-00056-00049904-00050712": "in the end their work would produce a reward for them the key word here is fruit they were called", "ffZK78HNBU8-00057-00050712-00051560": "to produce fruit but what did they do they had no intention of honoring this agreement", "ffZK78HNBU8-00058-00051616-00052336": "they did not want to be useful they did not want to be a benefit to the lord of this estate", "ffZK78HNBU8-00059-00052400-00053088": "but rather they wanted to exploit this relationship why for their own selfishness", "ffZK78HNBU8-00060-00053160-00054000": "they wanted what they wanted and they had no concern no thoughts for the expectations of", "ffZK78HNBU8-00061-00054000-00054736": "this master of the vineyard so when he sent the servants notice how they acted they just didn't", "ffZK78HNBU8-00062-00054736-00055664": "say no but they beat a man and presumably beat him severely another they killed and another they", "ffZK78HNBU8-00063-00055664-00056855": "stone and presumably stoned to death verse 36. again he sent other servants more than the first", "ffZK78HNBU8-00064-00056967-00058096": "and these vineyard workers we read and they did to them likewise finally look now to verse 37. i say", "ffZK78HNBU8-00065-00058096-00059136": "finally because this vineyard master he is going to take a very significant action he is going to", "ffZK78HNBU8-00066-00059136-00060472": "send notice what the text says his very son and we read here but afterwards he sent to them his son", "ffZK78HNBU8-00067-00060472-00061528": "sane they will honor my son now we're going to see that in this parable the the master the vineyard", "ffZK78HNBU8-00068-00061648-00062472": "this one relates to god and there's something that we need to learn about parables parables are big", "ffZK78HNBU8-00069-00062472-00063591": "picture messages we cannot take a biblical parable and extend every aspect to this parable in a very", "ffZK78HNBU8-00070-00063591-00064304": "very dogmatic way the reason why i say this what does god know god knows everything", "ffZK78HNBU8-00071-00064360-00065088": "does god ever make a mistake he does not he knows all and he behaves perfectly", "ffZK78HNBU8-00072-00065184-00065984": "but here in this parable for the purpose of illustrating the behavior the mindset", "ffZK78HNBU8-00073-00066064-00066784": "the the attitude of these vineyard workers what did they do well he says i will send to them", "ffZK78HNBU8-00074-00066848-00067776": "my son and the implication is certainly they will respect him honor him they will respond", "ffZK78HNBU8-00075-00067848-00068640": "properly but we're going to find they did no such thing now again in reality god knows", "ffZK78HNBU8-00076-00068640-00069368": "everything but in this parable it is to show how their behavior was so shocking", "ffZK78HNBU8-00077-00069432-00070808": "so improper so we read my son they will honor verse 38 but the vineyard workers after seeing", "ffZK78HNBU8-00078-00070808-00071616": "and there's a change here it is not the word bleppo for normally perceiving seeing something", "ffZK78HNBU8-00079-00071696-00072464": "but this is a different greek word which means not just to see but to see with understanding to have", "ffZK78HNBU8-00080-00072560-00073488": "a proper perspective they knew very well who this one was and we're to see that undeniably", "ffZK78HNBU8-00081-00073488-00074512": "once more verse 38 but the vineyard workers seen the son said among themselves this is", "ffZK78HNBU8-00082-00074512-00075360": "the heir they understood he's the one who eventually this vineyard's going to belong to", "ffZK78HNBU8-00083-00075432-00076616": "and they said come let us kill him and we will cease now this is a word for having now many times", "ffZK78HNBU8-00084-00076616-00077504": "i point out to you that there are two primary greek new testaments that that we have and one", "ffZK78HNBU8-00085-00077560-00078440": "for example the king james is based off of and and most other translations base their texts on", "ffZK78HNBU8-00086-00078440-00079176": "a different one and i feel a very inferior one but we see some minor differences here", "ffZK78HNBU8-00087-00079272-00080232": "in the the other greek texts it simply says that they will have the inheritance but in the texas", "ffZK78HNBU8-00088-00080232-00081136": "receptus there is a word it's the same root but it has a prefix added onto it and this means to", "ffZK78HNBU8-00089-00081136-00082248": "have something but the nuance is to do so with a purpose to do so in a secure way in other words", "ffZK78HNBU8-00090-00082248-00082960": "they believe something they believe that if they kill this air that they will secure for themselves", "ffZK78HNBU8-00091-00083032-00083720": "what they want what they have in their possession right now they're at the vineyard and they want", "ffZK78HNBU8-00092-00083720-00084608": "the vineyard and they're willing to kill the master son for it so they killed him and they", "ffZK78HNBU8-00093-00084608-00085328": "seized with purpose with understanding with intent his inheritance verse 39", "ffZK78HNBU8-00094-00085504-00086656": "and after taking him they cast them outside now again to show their their disdain their total", "ffZK78HNBU8-00095-00086656-00087520": "rejection of this heir the son of the lord what did they do well if we read carefully", "ffZK78HNBU8-00096-00087520-00088408": "this word for casting it's literally to cast out and then we have the word outside it is to", "ffZK78HNBU8-00097-00088408-00089600": "show a total absolute rejection of so we read and after taking him they cast him out outside", "ffZK78HNBU8-00098-00089600-00090320": "the vineyard and now we have the phrase they killed so we have that clarity they", "ffZK78HNBU8-00099-00090320-00091304": "put him to death verse 34 verse 40. therefore now we're coming to the conclusion of the matter", "ffZK78HNBU8-00100-00091440-00092336": "therefore whenever the lord of the vineyard now realize something in the scripture we see that for", "ffZK78HNBU8-00101-00092336-00093552": "example in prophecy in isaiah chapter 5 israel is likened to a vineyard we know that that in several", "ffZK78HNBU8-00102-00093552-00094392": "ways the scripture speaks about israel as an instrument that is called called to produce fruit", "ffZK78HNBU8-00103-00094472-00095112": "sometimes a vineyard sometimes a fig tree but the key here is when we look at this passage", "ffZK78HNBU8-00104-00095112-00096256": "this parable the vineyard relates to israel and therefore when we read the lord or the master", "ffZK78HNBU8-00105-00096256-00097064": "of the vineyard what does this do this shows a close and inherent relationship between the", "ffZK78HNBU8-00106-00097064-00097888": "lord and obviously in this parable we're speaking about god we see a close relationship between the", "ffZK78HNBU8-00107-00097888-00098896": "living god the one true god the only god and israel that is how this parable identifies god", "ffZK78HNBU8-00108-00098992-00099768": "the master of the vineyard so it's very problematic when someone looks at this text", "ffZK78HNBU8-00109-00099832-00100520": "and what is said in a few minutes what we're going to read and study and they come to a conclusion as", "ffZK78HNBU8-00110-00100520-00101304": "much in christianity has and to say well this parable is about god severing his relationship", "ffZK78HNBU8-00111-00101304-00101960": "with israel this is something that is prophetically incorrect when you", "ffZK78HNBU8-00112-00101960-00102696": "read prophecy and i'm speaking about biblical prophecy isaiah jeremiah ezekiel the other", "ffZK78HNBU8-00113-00102696-00103511": "prophets what's usually referred to as the minor prophets we see repeatedly we see consistently", "ffZK78HNBU8-00114-00103568-00104704": "we see eternally that god is not going to cast aside his people there will be a remnant of israel", "ffZK78HNBU8-00115-00104792-00105359": "and what we're going to see in a few weeks is that until that remnant in the last days", "ffZK78HNBU8-00116-00105448-00106432": "proclaims in a loud voice blessed be he that comes in the name of the lord that is a phrase", "ffZK78HNBU8-00117-00106432-00107328": "from the psalms concerning the coming of messiah and when israel this remnant of the last days", "ffZK78HNBU8-00118-00107328-00107983": "proclaimed this what's going to happen when they say that and why is israel going to say that", "ffZK78HNBU8-00119-00108056-00108759": "because they're going to be looking for messiah they're going to be in the midst of the worst", "ffZK78HNBU8-00120-00108759-00109728": "time of trouble what the bible calls in jeremiah chapter 30 a time of trouble a time of of", "ffZK78HNBU8-00121-00109728-00110504": "tribulation for jacob and it's going to be in the midst of these very difficult times in fact", "ffZK78HNBU8-00122-00110504-00111535": "biblically the most difficult time for israel that they're going to desire the messiah recognizing", "ffZK78HNBU8-00123-00111535-00112183": "he's the savior that he's the only one only that promise of a coming righteous king", "ffZK78HNBU8-00124-00112272-00113040": "that is going to defeat the enemies of israel only he can save them at this time and they're going", "ffZK78HNBU8-00125-00113040-00113959": "to turn in hope and expectation and believing the promises of god and what's going to happen", "ffZK78HNBU8-00126-00114024-00114752": "messiah is going to come this is his second coming at the end of the age and he's going to deliver", "ffZK78HNBU8-00127-00114752-00115496": "israel and it's only when that happens that the kingdom of god is going to be established", "ffZK78HNBU8-00128-00115559-00116424": "so god does not deny his relationship with the jewish people he does not sever ties with israel", "ffZK78HNBU8-00129-00116480-00117335": "one who says that is prophetically incorrect he does not understand prophetic revelation and", "ffZK78HNBU8-00130-00117335-00118352": "we're going to prove that in a moment so notice again verse 40 therefore whenever shall come", "ffZK78HNBU8-00131-00118352-00118959": "the lord of the vineyard what will he do to those vineyard workers verse 41", "ffZK78HNBU8-00132-00119159-00119832": "they say to him now this is the crowd those who are listening to this parable", "ffZK78HNBU8-00133-00119928-00120759": "they say to him and i like this next phrase many bibles translated differently but it's the same", "ffZK78HNBU8-00134-00120759-00121568": "word in two grammatical different constructions it's a word cacos which is a word for evil the", "ffZK78HNBU8-00135-00121568-00122288": "first time it's a noun so it's evil ones and then that word appears again in a different form", "ffZK78HNBU8-00136-00122288-00123408": "but same word as an adjective so it says evil evil doers those who are really exceptionally", "ffZK78HNBU8-00137-00123408-00124008": "bad why because they're not interested in the will of god you need to ask yourself", "ffZK78HNBU8-00138-00124088-00124816": "are you interested in the will of god the reason why you accepted the gospel isn't so that you", "ffZK78HNBU8-00139-00124816-00125583": "will be a new creation receive the regeneration of the holy spirit so that you can know the truth and", "ffZK78HNBU8-00140-00125583-00126552": "here's the key and be able to perform do the truth now again we're not saved by our performance we're", "ffZK78HNBU8-00141-00126552-00127248": "not saved by doing something we're saved freely by the grace of god through faith in what he did", "ffZK78HNBU8-00142-00127335-00128232": "but here's the key after being saved by grace through faith one who truly is regenerated", "ffZK78HNBU8-00143-00128288-00128632": "they're going to think the bible affirms us in many different places", "ffZK78HNBU8-00144-00128720-00129559": "they're going to think differently and they're going to desire god's will their utmost passionate", "ffZK78HNBU8-00145-00129559-00130528": "desire is to obey the things of god these ones did not and what were they called evil evil doers", "ffZK78HNBU8-00146-00130632-00131472": "so what will the lord of the vineyard do look at the middle verse 41 and he will kill them", "ffZK78HNBU8-00147-00131560-00132648": "and the vineyard he will lease to other vineyard workers so he's not making a change in his plan", "ffZK78HNBU8-00148-00132736-00133352": "he originally wanted this vineyard to be worked on by vineyard workers", "ffZK78HNBU8-00149-00133456-00134200": "but now he's choosing other vineyard workers and how should we understand that should we as many", "ffZK78HNBU8-00150-00134200-00134984": "within christianity does simply reject israel saying that and there's a theology a theology", "ffZK78HNBU8-00151-00134984-00135672": "that's from the pit of hell called replacement theology that teaches that god has replaced", "ffZK78HNBU8-00152-00135672-00136592": "israel that that covenant god's obligations his promises what he said are no longer valid that is", "ffZK78HNBU8-00153-00136592-00137600": "heresy the word of god is eternal it is not going to fail god's will will be established", "ffZK78HNBU8-00154-00137680-00138536": "so he's going to lease out this vineyard to other vineyard workers who in the verse 41 who will give", "ffZK78HNBU8-00155-00138536-00139576": "to him the fruit in in their seasons meaning it's in the plural saying in a repetitive way", "ffZK78HNBU8-00156-00139672-00140776": "each and every time they're going to do and offer up to god what god desires verse 42", "ffZK78HNBU8-00157-00140936-00141752": "yeshua says to them and this is so important because we see this always he always turns to", "ffZK78HNBU8-00158-00141840-00142640": "the bible the hebrew bible the old testament in order for us to have a proper understanding of", "ffZK78HNBU8-00159-00142640-00143160": "what he said everything that he did everything that he taught was based upon scripture", "ffZK78HNBU8-00160-00143160-00144112": "so he says have you not read in the scripture and he quotes from psalm 118 verses 22 and 23", "ffZK78HNBU8-00161-00144112-00145056": "he says the stone which the builders have rejected this one has become the chief quarter meaning", "ffZK78HNBU8-00162-00145056-00145872": "the foundation and what's it speaking of the foundation for the purpose the will ultimately", "ffZK78HNBU8-00163-00145872-00146536": "the kingdom of god and it's interesting because judaism understands rashi taught this this fame", "ffZK78HNBU8-00164-00146536-00147256": "rabbinical commentator from a thousand years ago that this stone is indeed the messiah so once", "ffZK78HNBU8-00165-00147256-00148112": "again he says have you not read in the scripture the stone which the builders have rejected", "ffZK78HNBU8-00166-00148200-00149288": "this one has been made for the chief coroner it is from the lord this is and it is marvelous in", "ffZK78HNBU8-00167-00149288-00150024": "and hear this in our eyes now i believe that this is a reference in the plural our eyes", "ffZK78HNBU8-00168-00150024-00150688": "to perhaps the trinity god the father god the son and god the holy spirit perhaps it's speaking", "ffZK78HNBU8-00169-00150688-00151400": "about our eyes from from the heavenly courts but it's interesting that it says in our eyes", "ffZK78HNBU8-00170-00151400-00152296": "on account of this verse 43 on account of this i say to you that that the kingdom of god shall", "ffZK78HNBU8-00171-00152296-00153184": "be taken up from you who is he speaking to israel no we're going to see undeniably when he says you", "ffZK78HNBU8-00172-00153184-00154160": "he's talking about those rulers those individuals who have no desire to fulfill the purposes of god", "ffZK78HNBU8-00173-00154160-00154864": "not interested in the will of god so he says the kingdom of god will be taken from you and given to", "ffZK78HNBU8-00174-00154920-00155936": "and here's the next word it is the greek word from ethos nation now if we were translating this into", "ffZK78HNBU8-00175-00156032-00156728": "hebrew from greek it would be the hebrew word [__] and why is that so important because", "ffZK78HNBU8-00176-00156728-00157328": "prophetically and this is so vital that you see this see normally people hear the term", "ffZK78HNBU8-00177-00157328-00158168": "[__] and think of a non-jew but when we read in the book of genesis that wonderful covenant the", "ffZK78HNBU8-00178-00158168-00158968": "abrahamic covenant what does god say to abraham that you will become a great [__] and this", "ffZK78HNBU8-00179-00158968-00159504": "is what is referring to and prophetically when we read in the prophets when israel gets right", "ffZK78HNBU8-00180-00159504-00160232": "with god when israel repents and accepts the truth of god they're called a [__]", "ffZK78HNBU8-00181-00160232-00160896": "in relationship to this abrahamic promise that tells us the blessing is going to come so he says", "ffZK78HNBU8-00182-00161064-00162088": "and it will be taken from you and given to another nation that does fruit makes its fruit and then he", "ffZK78HNBU8-00183-00162088-00162752": "finally closes with a prophetic statement the one who falls upon this stone will be broken and upon", "ffZK78HNBU8-00184-00162752-00163496": "whom the stone falls upon will become dust and the pharisees and the high priests", "ffZK78HNBU8-00185-00163496-00164168": "having heard the parable his parable they knew concerning him that he had spoken and what did", "ffZK78HNBU8-00186-00164168-00164816": "they want to do well notice it was about them not the jewish people not the nation of israel", "ffZK78HNBU8-00187-00164816-00165488": "but about these unrighteous ungodly individuals not interested in the will of god he says", "ffZK78HNBU8-00188-00165576-00166208": "they knew that it was about them that he spoke this parable and they were seeking him to cease", "ffZK78HNBU8-00189-00166208-00167072": "to grasp him but they didn't why because fear of the crowd because they held him everyone held", "ffZK78HNBU8-00190-00167072-00167912": "him meaning messiah as a prophet a true prophet shalom well we hope you will benefit from today's", "ffZK78HNBU8-00191-00167912-00168432": "message and share it with others please plan to join us each week at this time and on this channel", "ffZK78HNBU8-00192-00168432-00169160": "for our broadcast of love israel.org again to find out more about us please visit our website love", "ffZK78HNBU8-00193-00169160-00169768": "israel dot o r g there you will find articles in numerous other lectures by baruch these teachings", "ffZK78HNBU8-00194-00169768-00170360": "are in video form may download them or watch them in streaming video until next week may the", "ffZK78HNBU8-00195-00170360-00170984": "lord bless you in our messiah yeshua that is jesus as you walk with him shalom from israel"}}, {"audio_id": "fg7mdWiejeu", "text": {"fg7mdWiejeu-00000-00000000-00000200": "Flora Cafe Dusun Bambu", "fg7mdWiejeu-00001-00000200-00000400": "Galeri Flora Indonesia", "fg7mdWiejeu-00002-00000400-00000600": "Coffee shop, Indonesian food, Western food"}}, {"audio_id": "fg8-5GK2PtU", "text": {"fg8-5GK2PtU-00000-00000065-00000735": "Whiplash is an injury you may have heard people get from car accidents, but it can be from", "fg8-5GK2PtU-00001-00000735-00000900": "a lot of other traumas as well.", "fg8-5GK2PtU-00002-00000900-00001433": "Hi, my name is Dr. Zach Shaw, and I am an upper cervical chiropractor with the Upper", "fg8-5GK2PtU-00003-00001433-00001897": "Cervical Spine Center, and today we are going to discuss whiplash.", "fg8-5GK2PtU-00004-00001897-00002543": "Most people think whiplash is when you get in a car accident, say rear-ended, and your", "fg8-5GK2PtU-00005-00002543-00002799": "head goes back and then abruptly forward.", "fg8-5GK2PtU-00006-00002799-00003322": "Yes, that is a form of whiplash, but it could also be from a sports injury, or a slip and", "fg8-5GK2PtU-00007-00003322-00004027": "fall - any type of movement where, basically, your body stops and your head continues to", "fg8-5GK2PtU-00008-00004027-00004376": "go, or your head stops, and your body keeps going.", "fg8-5GK2PtU-00009-00004376-00004911": "Therefore, a whiplash injury is specifically an injury of the neck.", "fg8-5GK2PtU-00010-00004911-00005011": "Why?", "fg8-5GK2PtU-00011-00005011-00005351": "Because either the head or body is in motion while the opposite in still, and the middle", "fg8-5GK2PtU-00012-00005351-00005733": "part, or your neck, is what takes all that force.", "fg8-5GK2PtU-00013-00005733-00006319": "The problem with a whiplash injury is many times it can be silent.", "fg8-5GK2PtU-00014-00006319-00006729": "You may have pain for a day or two, maybe even a couple of weeks, but eventually that", "fg8-5GK2PtU-00015-00006729-00007081": "pain subsides, and you think you are good to go.", "fg8-5GK2PtU-00016-00007081-00007384": "I am here to tell you that is not the case.", "fg8-5GK2PtU-00017-00007384-00007983": "Many, many people who come into our office who may be suffering from neck pain, or maybe", "fg8-5GK2PtU-00018-00007983-00008702": "they have back pain, or a stomach problem, or a breathing problem, and we can almost", "fg8-5GK2PtU-00019-00008702-00009047": "always attribute their symptom to some type of injury.", "fg8-5GK2PtU-00020-00009047-00009577": "Usually, that is a whiplash injury, potentially from decades ago.", "fg8-5GK2PtU-00021-00009577-00009813": "So, how does this happen?", "fg8-5GK2PtU-00022-00009813-00010378": "When a whiplash injury occurs, not only does it hurt the tendons and ligaments in the neck,", "fg8-5GK2PtU-00023-00010378-00011532": "but it also is very possible that the top bone in the neck, or the atlas bone, can misalign.", "fg8-5GK2PtU-00024-00011532-00012033": "Now, you need to know that the brain, the brainstem, and the spinal cord have no pain", "fg8-5GK2PtU-00025-00012033-00012133": "perception.", "fg8-5GK2PtU-00026-00012133-00012783": "The Atlas surrounds the brainstem, which means that if atlas is misaligned around the brainstem,", "fg8-5GK2PtU-00027-00012783-00013284": "putting pressure on the brainstem, you could never know it because it has no pain perception.", "fg8-5GK2PtU-00028-00013284-00013859": "You may never have any headaches or neck pain, no issues at all, but this bone is still misaligned.", "fg8-5GK2PtU-00029-00013859-00014301": "Over time, as that bone stays misaligned and you continue to go about life, the neck gets", "fg8-5GK2PtU-00030-00014301-00014706": "worse and more degenerated, even though you may feel nothing.", "fg8-5GK2PtU-00031-00014706-00014981": "Eventually, something is going to arise.", "fg8-5GK2PtU-00032-00014981-00015415": "We know that then when there is pressure on the nerve system, you are not going to function", "fg8-5GK2PtU-00033-00015415-00015804": "or heal like you should, and usually symptoms occur with that.", "fg8-5GK2PtU-00034-00015804-00016081": "So again, these are the effects of whiplash.", "fg8-5GK2PtU-00035-00016081-00016482": "It is the misalignment that causes the issue over time.", "fg8-5GK2PtU-00036-00016482-00016582": "What happens after you sustain a whiplash injury, given you know nothing about upper", "fg8-5GK2PtU-00037-00016582-00016682": "cervical care?", "fg8-5GK2PtU-00038-00016682-00016890": "You may go to the hospital with neck pain from whiplash.", "fg8-5GK2PtU-00039-00016890-00017495": "They give you some painkillers and muscle relaxers to help you get out of pain.", "fg8-5GK2PtU-00040-00017495-00018370": "The pills hopefully mitigate the pain while the tendons and ligaments heal, but they never", "fg8-5GK2PtU-00041-00018370-00018721": "fix the misalignment, so you never get to the cause.", "fg8-5GK2PtU-00042-00018721-00019255": "Time takes its toll and certain conditions arise in your body, all due to that fender", "fg8-5GK2PtU-00043-00019255-00020459": "bender you had 20 years ago that caused a “mild” case of whiplash.", "fg8-5GK2PtU-00044-00020459-00020962": "How does whiplash effect the rest of your body?", "fg8-5GK2PtU-00045-00020962-00021284": "Shouldn't you just only neck pain from a whiplash injury?", "fg8-5GK2PtU-00046-00021284-00021492": "Again, that is not the case.", "fg8-5GK2PtU-00047-00021492-00021912": "When the brainstem is compressed, due to a misalignment at the top of the neck, it can", "fg8-5GK2PtU-00048-00021912-00022368": "literally affect the entire nerve system, which is why we see issues other than neck", "fg8-5GK2PtU-00049-00022368-00022676": "pain when people have an atlas misalignment.", "fg8-5GK2PtU-00050-00022676-00023015": "The other thing is that the brain must always be balanced, so when this bone misaligns,", "fg8-5GK2PtU-00051-00023015-00023352": "it takes the head and brain with it.", "fg8-5GK2PtU-00052-00023352-00023856": "Now the body must force compensations throughout the spine to balance the brain.", "fg8-5GK2PtU-00053-00023856-00024202": "These compensations, over time, whether they be in your upper or lower back, even all the", "fg8-5GK2PtU-00054-00024202-00024782": "way down to your knees and feet, eventually turn into weak spots from gravity pushing", "fg8-5GK2PtU-00055-00024782-00025040": "down on them for years and years.", "fg8-5GK2PtU-00056-00025040-00025285": "These weak spots eventually turn into pain.", "fg8-5GK2PtU-00057-00025285-00025701": "We can do whatever we want to those weak spots, but until we get to the cause, which is that", "fg8-5GK2PtU-00058-00025701-00026364": "misalignment at the top of the neck, maybe caused by a whiplash injury, there is not", "fg8-5GK2PtU-00059-00026364-00026577": "much we can do.", "fg8-5GK2PtU-00060-00026577-00027074": "If you have had a whiplash injury in the past, or any injury where you hit your head on something,", "fg8-5GK2PtU-00061-00027074-00027670": "or your body stopped while your head kept going, or vice versa, get checked by an upper", "fg8-5GK2PtU-00062-00027670-00027805": "cervical doctor today.", "fg8-5GK2PtU-00063-00027805-00028303": "You are welcome to come to Charlotte, North Carolina to the Upper Cervical Spine Center.", "fg8-5GK2PtU-00064-00028303-00029306": "Give our office a call at (704) 588-5560 and we will be happy to do a free consultation", "fg8-5GK2PtU-00065-00029306-00029763": "to see if you are dealing with an upper cervical issue.", "fg8-5GK2PtU-00066-00029763-00030156": "If you are not in the Charlotte, North Carolina area, give our office a call anyway, and I", "fg8-5GK2PtU-00067-00030156-00030761": "promise we will do our absolute best to find an upper cervical doctor as close to you as", "fg8-5GK2PtU-00068-00030761-00030877": "possible.", "fg8-5GK2PtU-00069-00030877-00031094": "I hope you stay safe on those roads.", "fg8-5GK2PtU-00070-00031094-00031297": "I hope you stay safe in general.", "fg8-5GK2PtU-00071-00031297-00031397": "You have a wonderful day.", "fg8-5GK2PtU-00072-00031397-00031397": "Take care."}}, {"audio_id": "fgg1yUlyWc4", "text": {"fgg1yUlyWc4-00000-00000000-00197120": "INCEST (R.I.P.1995-2000)"}}, {"audio_id": "fghreZwegtQ", "text": {"fghreZwegtQ-00000-00000096-00000463": "to whatever time zone you're in good morning good afternoon or good evening", "fghreZwegtQ-00001-00000520-00001024": "the expansion of humankind into space is an international effort and we are super excited", "fghreZwegtQ-00002-00001024-00001384": "to share with you our experiment design from the little island nation of singapore", "fghreZwegtQ-00003-00001440-00001880": "today we'll talk you through our idea that could lay the brickwork for building a future in space", "fghreZwegtQ-00004-00002016-00002432": "this is our team we are a trio of 17 year olds from st", "fghreZwegtQ-00005-00002432-00002984": "joseph's institution international singapore united by common passion for science in space", "fghreZwegtQ-00006-00003247-00003656": "before we start here's a quote that we feel embodies the spirit of the launch prize", "fghreZwegtQ-00007-00003656-00004384": "competition space has the ability to produce a triple bottom line or roiii return on investment", "fghreZwegtQ-00008-00004384-00005040": "innovation and inspiration our hypothesis is that microgravity conditions will enhance the microbial", "fghreZwegtQ-00009-00005040-00005632": "growth of sporosarchina pasteurii and result in a greater cell concentration density by the end of", "fghreZwegtQ-00010-00005632-00006184": "a 20-day period now that's a mouthful and quite a lot of information packed into one sentence", "fghreZwegtQ-00011-00006184-00006520": "so we broke down this presentation into five main parts in the bibliography", "fghreZwegtQ-00012-00006592-00007120": "let's start off with introduction what exactly is Sporosarcina pasteurii and what makes it so", "fghreZwegtQ-00013-00007120-00008000": "promising Sporosarcina pasteurii abbreviated as S pasteurii or SP is a gram-positive bacteria", "fghreZwegtQ-00014-00008000-00008552": "with a biosafety level of one the safest possible classification a microbe can have", "fghreZwegtQ-00015-00008552-00009176": "so it is perfectly safe to be investigated on the iss especially is a hardy bacterial that", "fghreZwegtQ-00016-00009176-00009776": "can survive in highly alkaline environments and in the complete and prolonged absence of nutrients", "fghreZwegtQ-00017-00009776-00010392": "making it a perfect and durable candidate for experimentation in space what's really unique", "fghreZwegtQ-00018-00010392-00010920": "about S pasteurii is its ability to undergo urolysis driven microbially induced calcite", "fghreZwegtQ-00019-00010920-00011664": "precipitation otherwise abbreviated as micp it takes in urea a compound found in urine", "fghreZwegtQ-00020-00011664-00012216": "and then secretes calcium carbonate from it, a key compound that makes up limestone rock in other", "fghreZwegtQ-00021-00012216-00012760": "words it turns pee into bricks the mechanisms by which it does this will be explained later on in", "fghreZwegtQ-00022-00012760-00013368": "more detail in the bottom right hand corner is the chemical equation illustrating the micp process", "fghreZwegtQ-00023-00013472-00013872": "lots of progress is being made in the area of producing S pasteurii bricks", "fghreZwegtQ-00024-00013928-00014296": "and while they aren't quite ready to be mass-produced at a commercial level yet", "fghreZwegtQ-00025-00014296-00014696": "researchers are experimenting with different nutrient sources to maximize the strength of", "fghreZwegtQ-00026-00014696-00015216": "precipitated calcium carbonate the prospects are promising and has been scientifically", "fghreZwegtQ-00027-00015216-00015680": "proved that the bricks produced by micp are of a similar strength to normal bricks", "fghreZwegtQ-00028-00015800-00016408": "now let's get into the background importance and benefits of our project we started our launch", "fghreZwegtQ-00029-00016408-00016864": "prize journey in april this year brainstorming the different ways we could tap into the needs of both", "fghreZwegtQ-00030-00016864-00017432": "the space program and humankind our initial ideas included things like measuring the decomposition", "fghreZwegtQ-00031-00017432-00018032": "of bioplastics and also the gravitropism of plants eventually we realized that if humans were", "fghreZwegtQ-00032-00018032-00018560": "to become an interstellar species or simply were to have greater presence on planets in our solar", "fghreZwegtQ-00033-00018560-00019304": "system like mars there would be a need to produce materials in space at the moment there is a hefty", "fghreZwegtQ-00034-00019304-00019960": "price tag associated with shipping things to space 10 000 usd that's how much nasa estimates it costs", "fghreZwegtQ-00035-00019960-00020560": "just to ship one pound of material to lunar orbit for space expansion to be economically viable", "fghreZwegtQ-00036-00020560-00021112": "and not drain our resource of cash dry any production process must have minimal dependence on", "fghreZwegtQ-00037-00021112-00021768": "external resources meaning that things need to be produced in space not on earth and shipped to space", "fghreZwegtQ-00038-00021768-00022152": "now this is where S pasteurii and its calcite precipitating abilities come in", "fghreZwegtQ-00039-00022216-00022760": "urea a readily available substance found in urine can be easily accessed to produce construction", "fghreZwegtQ-00040-00022760-00023376": "materials like bio bricks via S pasteurii although the crude image of an astronaut peeing on a petri", "fghreZwegtQ-00041-00023376-00023840": "dish springs to mind and seems like something out of a science fiction novel it's actually", "fghreZwegtQ-00042-00023840-00024336": "been scientifically proved that biobricks of a similar strength to normal bricks can be made", "fghreZwegtQ-00043-00024336-00024984": "using human urine and S pasteurii now if you ask us that is pretty incredible and testament to both", "fghreZwegtQ-00044-00024984-00025464": "the resourcefulness of humanity and nature and we're not the only ones who think that either", "fghreZwegtQ-00045-00025528-00026016": "over the past few years there's been growing interest in the micp in the science community this", "fghreZwegtQ-00046-00026016-00026600": "bar chart starts from the scopus database on 16th june 2020 shows the growth of publications with", "fghreZwegtQ-00047-00026600-00027272": "keywords microbially induced calcite precipitation microbial urease and urelotic from 1999 to 2020.", "fghreZwegtQ-00048-00027336-00027904": "Bianca J Reeksting elegantly articulated our sentiments towards Sporosarcina pasteurii as", "fghreZwegtQ-00049-00027904-00028488": "the future of industrial production in her march 2020 paper saying that it represents the paradigm", "fghreZwegtQ-00050-00028488-00029104": "organism for industrial application of calcite precipitation other space organizations like the", "fghreZwegtQ-00051-00029104-00029680": "indian space research organization have explored the possibility of constructing space bricks using", "fghreZwegtQ-00052-00029680-00030248": "lunar soil stimulant containing S pasteurii and their conclusion has stated that their results", "fghreZwegtQ-00053-00030248-00030720": "makes this entire process a very attractive and sustainable option for producing free form", "fghreZwegtQ-00054-00030720-00031192": "structures using lunar regolith based building blocks and extraterrestrial habitats", "fghreZwegtQ-00055-00031304-00031768": "in an effort to understand more about S pasteurii and where research currently stands", "fghreZwegtQ-00056-00031768-00032288": "we took matters into our own hands and emailed professor aloke kumar a key contributor to the", "fghreZwegtQ-00057-00032288-00032800": "paper in the previous slide and we've been in correspondence with him since june he's been", "fghreZwegtQ-00058-00032800-00033376": "helping us by answering our questions and sending us copies of his publications professors kumar's", "fghreZwegtQ-00059-00033376-00034064": "2019 and 2020 research has surrounded S pasteurii and his possible implementations in microgravity", "fghreZwegtQ-00060-00034064-00034568": "however his papers mainly focus on maximizing the compressive strength of S Pasteurii  bricks", "fghreZwegtQ-00061-00034568-00035136": "not investigating the actual behavior of the bacteria in space in fact there has yet to be", "fghreZwegtQ-00062-00035136-00035640": "an actual experiment conducted in microgravity conditions for S Pasteurii despite all the recent", "fghreZwegtQ-00063-00035640-00036272": "craze surrounding it in order for the dream of producing space bricks to become a reality", "fghreZwegtQ-00064-00036272-00036800": "we will have to first understand how microgravity actually contributes to the microbial growth of", "fghreZwegtQ-00065-00036800-00037400": "the bacteria in space and this necessitates the need for an experiment such as ours", "fghreZwegtQ-00066-00037400-00037880": "a novel investigation that will act as the first step towards making industrial production space", "fghreZwegtQ-00067-00037880-00038408": "achievable we will go into further justification for our experiment in the hypothesis justification", "fghreZwegtQ-00068-00038408-00038968": "segment of our presentation calcium carbonate produced by S pasteurii can even help terraform", "fghreZwegtQ-00069-00038968-00039544": "planets on earth research has shown that micp can strengthen and stabilize soil by filling the", "fghreZwegtQ-00070-00039544-00040184": "gaps between sand grains in 2020 scientists use the bacteria to improve wind erosion resistance", "fghreZwegtQ-00071-00040184-00040736": "of sand dunes in iran if we're looking to eventually build structures on other planets micp", "fghreZwegtQ-00072-00040736-00041296": "won't just help us build bricks for infrastructure but also help us stabilize the physical landscape", "fghreZwegtQ-00073-00041296-00041744": "and ensure that geological features like cliffs and rock faces are secure and safe", "fghreZwegtQ-00074-00041872-00042328": "S pasteurii is also a greener and more sustainable alternative to cement", "fghreZwegtQ-00075-00042328-00042736": "minimizing the damage we could bring to the physical environments of other planets", "fghreZwegtQ-00076-00042896-00043400": "so now you see how Sporosarcina pasteurii can benefit the space program but what about", "fghreZwegtQ-00077-00043400-00044088": "us here on earth Sporosarcina pasteurii offers a sustainable and green way of producing materials", "fghreZwegtQ-00078-00044088-00044664": "in general traditional brick manufacturing actually creates more pollution than the entire", "fghreZwegtQ-00079-00044664-00045208": "aviation industry and making a couple of breaks generates more than a kilogram of carbon dioxide", "fghreZwegtQ-00080-00045272-00045784": "furthermore toxic heavy metals and reactive wastes resulting from rapid urbanization can", "fghreZwegtQ-00081-00045784-00046528": "be detoxed by the process of micp as it alters the chemical form of these heavy metals from soluble", "fghreZwegtQ-00082-00046528-00047008": "to insoluble meaning that the toxic elements won't be able to dissolve into our water systems", "fghreZwegtQ-00083-00047072-00047664": "it is also a relatively new field of interest in the research community so observing how it behaves", "fghreZwegtQ-00084-00047664-00048160": "in different environments like microgravity could aid our understanding of the organism and help us", "fghreZwegtQ-00085-00048160-00048664": "improve our culturing techniques move us one step closer to building a better home on earth", "fghreZwegtQ-00086-00048792-00049280": "naturally we were super excited about our project and there's potential benefits for humankind this", "fghreZwegtQ-00087-00049280-00049864": "is the exact reason we register for the contest to find a way to make a difference unfortunately", "fghreZwegtQ-00088-00049864-00050352": "our microbiology knowledge is limited to high school biology classes so we had a bit of", "fghreZwegtQ-00089-00050352-00050768": "trouble understanding research papers and didn't really know how to start planning our experiment", "fghreZwegtQ-00090-00050768-00051384": "or what exactly to investigate we emailed a total of 19 professors from all over the world who have", "fghreZwegtQ-00091-00051384-00051864": "published papers on especially to our pleasant surprise we weren't outright ignored by all of", "fghreZwegtQ-00092-00051864-00052391": "them and eight of them actually replied to give this presentation without acknowledging their help", "fghreZwegtQ-00093-00052391-00052872": "would be unfair so we would like to extend our thanks to all the professors who validated our", "fghreZwegtQ-00094-00052872-00053312": "claims and assisted us in this process you now have an understanding of S Pasteurii", "fghreZwegtQ-00095-00053312-00053879": "and its incredible micp capabilities so hopefully our hypothesis makes a bit more sense", "fghreZwegtQ-00096-00053952-00054328": "we present that microgravity conditions will stimulate the microbial growth", "fghreZwegtQ-00097-00054328-00054879": "of S pasteurii and result in a greater cell concentration density by the end of a 20-day", "fghreZwegtQ-00098-00054879-00055472": "growth period why measure microbial growth and not calcium concentration density directly", "fghreZwegtQ-00099-00055528-00056040": "this is actually one of the biggest hurdles we faced as doing so will require laboratory level", "fghreZwegtQ-00100-00056040-00056616": "analysis that is difficult if not outright impossible to perform on the iss in overcoming", "fghreZwegtQ-00101-00056616-00057055": "this we learned that there was actually a direct relationship between the number of cells", "fghreZwegtQ-00102-00057120-00057720": "and its bio mineralization capacity to validate this claim we emailed two professors in the field", "fghreZwegtQ-00103-00057776-00058232": "professor Omoregie from australia and professor basaran from turkey", "fghreZwegtQ-00104-00058232-00058720": "both responded positively and provided us with the literature to support the claim of a direct", "fghreZwegtQ-00105-00058720-00059240": "relationship this graph illustrates the direct relationship of calcium carbonate production and", "fghreZwegtQ-00106-00059240-00059832": "microbial growth albeit using the alternative variable shear weight velocity and time", "fghreZwegtQ-00107-00059832-00060504": "the y-axis shows sheer weight velocity a measure of the mechanical property of soil as more calcium", "fghreZwegtQ-00108-00060504-00061024": "carbonate is produced the stiffness of the soil increases increasing shear velocity as well", "fghreZwegtQ-00109-00061079-00061696": "the x-axis shows time which corresponds to the bacterial growth over a specified duration we", "fghreZwegtQ-00110-00061696-00062224": "can see that the relationship between shear weight velocity and time is directly proportional", "fghreZwegtQ-00111-00062224-00062752": "illustrating how calcium carbonate precipitation is directly related to cell concentration", "fghreZwegtQ-00112-00062832-00063376": "this excerpt also offers an explanation to show the direct relationship between calcium carbonate", "fghreZwegtQ-00113-00063376-00063936": "precipitation and cell concentration this image shows how S pasteurii cells", "fghreZwegtQ-00114-00063936-00064472": "produce calcium carbonate precipitates the cells are actually the location of calcium carbonate", "fghreZwegtQ-00115-00064472-00064952": "production so increasing the number of cells will logically increase the amount of calcium carbonate", "fghreZwegtQ-00116-00065016-00065568": "so why do we believe that microgravity will enhance microbial growth first of all research", "fghreZwegtQ-00117-00065568-00066056": "shows that motile microorganisms can move into fresh nutrient areas this means that they can", "fghreZwegtQ-00118-00066056-00066632": "move around in their containers to consume more nutrients previous phase experiments have also", "fghreZwegtQ-00119-00066632-00067128": "reported different cell concentrations during early exponential growth periods with respect", "fghreZwegtQ-00120-00067128-00067576": "to ground controls which gives us all the more reason to believe in this hypothesis", "fghreZwegtQ-00121-00067720-00068216": "professor rosa santomartino published a paper recently following her experiment on growth rates", "fghreZwegtQ-00122-00068216-00068728": "of various bacteria on the iss she stated in her paper that there have been contradicting results", "fghreZwegtQ-00123-00068728-00069232": "regarding the effect microgravity has on microbial growth while some professors have found that", "fghreZwegtQ-00124-00069232-00069736": "microgravity enhances microbial growth others like professor santomartino have reported no change", "fghreZwegtQ-00125-00069736-00070320": "whatsoever in other words nobody is really sure what affects microgravity has a microbial growth", "fghreZwegtQ-00126-00070320-00070800": "and researchers like santomartino have explicitly stated that more investigation is needed", "fghreZwegtQ-00127-00070800-00071296": "especially with different sorts of bacteria further justifying our novel experiment with S", "fghreZwegtQ-00128-00071296-00071824": "pasteurii we structured our hypothesis around the 20-day growth period as this time frame", "fghreZwegtQ-00129-00071824-00072424": "mimics those of bio-industrial processes which typically last over a few weeks we also adapted", "fghreZwegtQ-00130-00072424-00072992": "our compartment design to measure the early growth phase which lasts about 12 hours of S pasteurii", "fghreZwegtQ-00131-00073088-00073576": "so far there are a few experiments which have investigated early growth phases of bacteria in", "fghreZwegtQ-00132-00073576-00074096": "real microgravity in fact most of the research surrounding early growth phases are actually", "fghreZwegtQ-00133-00074096-00074680": "conducted in simulated microgravity rosa santomartino's team focused on stationary", "fghreZwegtQ-00134-00074680-00075208": "phase growth so they are unable to come up with data for the early growth phase other experiments", "fghreZwegtQ-00135-00075208-00075768": "are focused purely on early growth phases with no data in longer time periods one of the first", "fghreZwegtQ-00136-00075768-00076320": "ways we will investigate the bacterial growth is by using real-time optical density measurements", "fghreZwegtQ-00137-00076320-00076840": "what is optical density optical density is a common technique used in microbiology to measure", "fghreZwegtQ-00138-00076840-00077360": "bacterial cultures it measures the amount of light passing through an optical component in this case", "fghreZwegtQ-00139-00077360-00077920": "our bacteria inoculated petri dish and as the bacteria colonies grow and fill up the petri dish", "fghreZwegtQ-00140-00077976-00078472": "less and less light will be let through and our light sensor will record this usually", "fghreZwegtQ-00141-00078472-00079040": "researchers use spectral photometers to make these measurements but these machines are way too big", "fghreZwegtQ-00142-00079040-00079672": "to fit into 100 millimeter by 100 millimeter by 50 millimeter box so unless you're antman and have", "fghreZwegtQ-00143-00079672-00080168": "the power of quantum physics to shrink objects you are not going to fit a spectrophotometer on", "fghreZwegtQ-00144-00080168-00080768": "the iss in the word of their grilles we had to adapt improvise and overcome this next section", "fghreZwegtQ-00145-00080768-00081320": "will detail our compartment design process using a computer-aided design software called onshape", "fghreZwegtQ-00146-00081376-00081912": "we created a virtual model of our compartment the compartment contains of four individual cartridges", "fghreZwegtQ-00147-00082040-00082648": "inside it we've placed a small petri dish of diameter 35mm supported underneath by", "fghreZwegtQ-00148-00082648-00083232": "two cylinders small cylinders to prevent the dish from floating in microgravity", "fghreZwegtQ-00149-00083344-00083832": "beneath the dish is a sensor from texas instruments", "fghreZwegtQ-00150-00084000-00084568": "which receives light from an aluminium substrate led mounted on the on the lid", "fghreZwegtQ-00151-00084784-00085584": "here's the led basically the led will shine through the petri dish", "fghreZwegtQ-00152-00085640-00086192": "containing our bacteria colony and agar and the light sensor at the bottom will record the amount", "fghreZwegtQ-00153-00086192-00086784": "of light getting through as bacteria grows less light will get through to ensure that there is", "fghreZwegtQ-00154-00086784-00087400": "an equal distribution of light getting to the petri dish surface we stuck a diffuser sheet", "fghreZwegtQ-00155-00087688-00088176": "to the bottom of the dish we came up with a calibration system to regulate", "fghreZwegtQ-00156-00088176-00088680": "the amount of light inside the petri dish a simple light dependent resistor", "fghreZwegtQ-00157-00088856-00089824": "and it's attached to the rim of the petri dish right around there", "fghreZwegtQ-00158-00089824-00090488": "and this simple ldr will detect the overall light intensity coming from", "fghreZwegtQ-00159-00090552-00091184": "the led and any ambient light and via a calibration circuit", "fghreZwegtQ-00160-00091560-00091760": "it will adjust internal leds", "fghreZwegtQ-00161-00092072-00093048": "power to control the whole lighting apparatus this should account for sudden changes in the light", "fghreZwegtQ-00162-00093104-00093696": "and it should allow for the total intensity inside the dish and the total intensity incident on the", "fghreZwegtQ-00163-00093696-00094264": "petri dish to be constant furthermore the whole light apparatus will be wrapped in a black sheet", "fghreZwegtQ-00164-00094264-00094840": "of paper to absorb any stray ambient light though we expect this to be minimal since the cartridge", "fghreZwegtQ-00165-00094840-00095760": "and lid are made of opaque materials we have also mounted a small 1080p cmos camera next to the led", "fghreZwegtQ-00166-00096512-00096960": "these photos along with the optical density data will be saved to an external hard drive", "fghreZwegtQ-00167-00096960-00097216": "and can be accessed later for qualitative analysis", "fghreZwegtQ-00168-00097304-00097664": "everything in our cartridge is powered by batteries at the moment we are unsure of the", "fghreZwegtQ-00169-00097664-00098280": "specific model and size of batteries to use but we did leave sufficient space to slot them inside", "fghreZwegtQ-00170-00098592-00099296": "this is what all four of our small cartridges should look like in one compartment", "fghreZwegtQ-00171-00099296-00099920": "all the cartridges will be made from a single chunk of aluminium 6061 alloy as having less", "fghreZwegtQ-00172-00099920-00100600": "individual parts will and greatly improve rigidity this tiny little thing is a vial", "fghreZwegtQ-00173-00100856-00101504": "intended to hold our sample of S Pasteurii if needed our cute little raspberry pico here is", "fghreZwegtQ-00174-00101504-00102104": "the center of data processing and collection it is mounted diagonally to optimize space", "fghreZwegtQ-00175-00102256-00102880": "here are the extra spaces available for the batteries this only looks like four lids", "fghreZwegtQ-00176-00102880-00103535": "because it is easier to cad model this way in reality these four should be one coherent piece", "fghreZwegtQ-00177-00103616-00104232": "and it should be 3d printed as one piece this box as well should be 3d printed as one piece", "fghreZwegtQ-00178-00104359-00104896": "this is again for rigidity and ease of manufacturing everything will be secured with", "fghreZwegtQ-00179-00104896-00105559": "screws or glue and all electronics will be rubber coated to prevent damage in case of a leak we came", "fghreZwegtQ-00180-00105559-00106000": "up with the optical density sensor idea prior to discovering that it was an actual technique", "fghreZwegtQ-00181-00106000-00106480": "used by microbiologists so it was a real relief finding out that our brainstorming had roots and", "fghreZwegtQ-00182-00106480-00106992": "tangible science it was difficult scaling down the optical density apparentness to the size of our", "fghreZwegtQ-00183-00106992-00107504": "compartment as far as we were concerned nobody had really attempted real-time optical density", "fghreZwegtQ-00184-00107504-00108088": "measurement with such size limitations nonetheless we were devoted to our design as we saw it as one", "fghreZwegtQ-00185-00108088-00108511": "of the best ways to retrieve quantitative data on the bacteria's early growth phase", "fghreZwegtQ-00186-00108752-00109200": "we created several prototypes of our initial design and emailed the penultimate prototype to", "fghreZwegtQ-00187-00109200-00109672": "professor kumar to see what he thought fortunately he responded by saying that he had actually", "fghreZwegtQ-00188-00109672-00110296": "published a paper with a similar design to ours honestly the day he sent this email was one of our", "fghreZwegtQ-00189-00110296-00110840": "year's highlights because it meant that the design we had come up with on our own actually worked it", "fghreZwegtQ-00190-00110840-00111320": "just so happened that professor kumar's design was almost identical to ours and his publication", "fghreZwegtQ-00191-00111320-00111968": "provided valuable proof that the sensor circuit worked in real life our entire compartment is", "fghreZwegtQ-00192-00111968-00112544": "designed to be easy to use and minimize astronaut interaction except for setup and disassembly", "fghreZwegtQ-00193-00112600-00113200": "it is completely autonomous furthermore the presence of both camera and light sensors ensure", "fghreZwegtQ-00194-00113200-00113696": "that we have backup data retrieval methods should one system fail midway through the experiment", "fghreZwegtQ-00195-00113783-00114383": "we also plan on taking pre and post experiment photos so in case all else fails we will at least", "fghreZwegtQ-00196-00114383-00114776": "be able to conduct a cell count to deduce the change in cell concentration density", "fghreZwegtQ-00197-00114856-00115383": "this wouldn't be a complete traversity as final cell concentration density does provide valuable", "fghreZwegtQ-00198-00115383-00116064": "results as professor santomartino mentioned in a 2020 paper more experiments measuring final cell", "fghreZwegtQ-00199-00116064-00116688": "concentration density need to be conducted in microgravity overall our compartment is", "fghreZwegtQ-00200-00116688-00117224": "a three-in-one measuring device allowing us to record data using obstacle density camera images", "fghreZwegtQ-00201-00117224-00117792": "and cell counts if any one of these techniques are not possible for any reason the other two serve as", "fghreZwegtQ-00202-00117792-00118400": "viable alternatives to retrieve data here is the basic experiment flow diagram showing the entire", "fghreZwegtQ-00203-00118400-00118976": "process the pink lilac rectangle corresponds to the flight experiments and the mint rectangle", "fghreZwegtQ-00204-00118976-00119592": "corresponds to the ground controls now for the methodology to understand how bacterial cultures", "fghreZwegtQ-00205-00119592-00120192": "work we email professors from local universities watch youtube videos read methods of similar", "fghreZwegtQ-00206-00120192-00120744": "iss experiments research S Pasteurii   culture preparation techniques and interview teachers", "fghreZwegtQ-00207-00120744-00121304": "from our school we are not experts in the field of microbiology although i do feel like i could", "fghreZwegtQ-00208-00121304-00121776": "write a paper on S Pasteurii  at this point but we tried our best to come up with a viable method", "fghreZwegtQ-00209-00121911-00122559": "for microbiology experiments on the iss spores of the bacteria first need to be cultivated on earth", "fghreZwegtQ-00210-00122559-00123088": "then they can be frozen and put to sleep while in transport and eventually woken up by", "fghreZwegtQ-00211-00123088-00123688": "incubating and using nutrient medium on the iss here are the variables for our experiment", "fghreZwegtQ-00212-00123752-00124176": "obviously the independent variable is the gravitational pull applied on the growth", "fghreZwegtQ-00213-00124176-00124911": "environment of Sporosarcina pasteurii that is the 1g on the ground compared to the pseudo zero g", "fghreZwegtQ-00214-00124911-00125504": "on the iss the dependent variable as stated in our hypothesis will be the microbial", "fghreZwegtQ-00215-00125504-00126111": "growth of  Sporosarcina pasteurii this will be measured by the rate of exponential growth", "fghreZwegtQ-00216-00126111-00126824": "as an increase of optical density as a function of time the control variables are everything about", "fghreZwegtQ-00217-00126824-00127304": "the growth environment other than gravitational force this will include the content of nutrient", "fghreZwegtQ-00218-00127304-00127848": "broth the content of air the volume of air accessible the total lux of light incident on", "fghreZwegtQ-00219-00127848-00128511": "the bacteria total optical density of air between the led and the bacteria the petri dish and the", "fghreZwegtQ-00220-00128511-00129048": "agar nutrient mixture the diffuse sheet the air between the diffuser sheet and the light sensor", "fghreZwegtQ-00221-00129128-00129616": "all the properties of the electronic devices such as the resistance in the circuit board", "fghreZwegtQ-00222-00129616-00130224": "traces the time of data collection this includes the light intensity measurements and photo taking", "fghreZwegtQ-00223-00130368-00130904": "and lastly it goes without saying of course the bacteria used should be constant our beloved", "fghreZwegtQ-00224-00130959-00131600": "Sporosarcina pasteurii the first main stage of our method is to prepare the bacteria for", "fghreZwegtQ-00225-00131600-00132256": "suspension we basically create bacteria pellets to be used as inoculum for the iss experiment", "fghreZwegtQ-00226-00132336-00132664": "the second stage is preparing our compartment and samples for launch", "fghreZwegtQ-00227-00132728-00133120": "we simply need to ensure that all our equipment is in place and working", "fghreZwegtQ-00228-00133120-00133560": "the final stage will be carried out on the iss all the astronauts really have to do", "fghreZwegtQ-00229-00133560-00134072": "is unbox the bacterial samples and wake them up by injecting growth medium and incubating them", "fghreZwegtQ-00230-00134136-00134680": "after that the astronauts can leave the bacteria to grow on its own as our sensors and cameras will", "fghreZwegtQ-00231-00134680-00135288": "record real-time data here's our shopping list of materials if you ask us there's no better retail", "fghreZwegtQ-00232-00135288-00135928": "therapy than buying bacteria strains and petri dishes we can procure Sporosarcina pasteurii from", "fghreZwegtQ-00233-00135928-00136480": "atcc and the growth medium actually comes with the bacteria which is great we love a buy one get", "fghreZwegtQ-00234-00136480-00137168": "one free bundle and the sporulation broth medium can be made following the procedure suggested by", "fghreZwegtQ-00235-00137168-00137824": "monterino et al. in 2005 the hardware equipment for our compartment can be bought from so many", "fghreZwegtQ-00236-00137824-00138328": "different sources but these are the ones that we suggest so there's half a year's worth of research", "fghreZwegtQ-00237-00138392-00138824": "in case it was too difficult to digest all of that we're going to run through the salient points", "fghreZwegtQ-00238-00138824-00139312": "of our experiment proposal tackling each of the judging criteria published by the isset", "fghreZwegtQ-00239-00139400-00140040": "is our experiment feasible yes it is similar experiments have been conducted on the iss before", "fghreZwegtQ-00240-00140040-00140608": "so it's not a hail mary the indian space research organization has also recently started to", "fghreZwegtQ-00241-00140608-00141176": "look into designing Sporosarcina pasteurii experiments proving that this is a feasible possibility is", "fghreZwegtQ-00242-00141176-00141936": "our experiment novel yes despite the popularity of s pasteurii in the scientific community nobody has", "fghreZwegtQ-00243-00141936-00142568": "actually conducted experiments using it on the iss yet which means ours will be the first of its kind", "fghreZwegtQ-00244-00142624-00143104": "it will be one of the first experiments to measure real-time exponential growth of bacteria in", "fghreZwegtQ-00245-00143104-00143736": "microgravity it lays the groundwork for humans to become an interstellar species and build habitats", "fghreZwegtQ-00246-00143736-00144264": "on space learning more about the bacteria's behavior in different environments can help us", "fghreZwegtQ-00247-00144264-00144856": "understand it better and contribute to developing sustainable production processes here on earth and", "fghreZwegtQ-00248-00144856-00145632": "finally it turns urine into cement which is pretty darn incredible is our experiment safe yes it has", "fghreZwegtQ-00249-00145632-00146128": "to save this bio safety level of one and similar bacteria have been researched on the iss in the", "fghreZwegtQ-00250-00146128-00146752": "past is our experiment automated yes a custom compartment design fitted with light sensors", "fghreZwegtQ-00251-00146752-00147424": "and a camera collect real-time data and save it to an sd card is our hypothesis clear and justified", "fghreZwegtQ-00252-00147424-00147936": "yes we believe that microbial growth will be enhanced in microgravity because the bacteria", "fghreZwegtQ-00253-00147936-00148456": "has a chance to flow around in its sediment and move to new areas of nutrient broth furthermore", "fghreZwegtQ-00254-00148456-00148952": "our experiment will provide valuable results into investigating the effects of microgravity", "fghreZwegtQ-00255-00148952-00149544": "on microbial growth an area that researchers have stressed needs more experimentation", "fghreZwegtQ-00256-00149664-00150264": "and that's it thank you so much for coming and taking the time to listen to us today we are", "fghreZwegtQ-00257-00150264-00150816": "immensely grateful for the opportunity to be part of this competition and we went from microbiology", "fghreZwegtQ-00258-00150816-00151400": "zeros to self-proclaimed microbiology heroes we hope that you enjoyed our presentation and that", "fghreZwegtQ-00259-00151400-00151953": "you will join us on our journey to make biobrick production and space a reality thank you again"}}, {"audio_id": "fgp_nxuXg-u", "text": {"fgp_nxuXg-u-00000-00000000-00010570": "🌟 🇺🇸 Costumes of Sailors and Jung Kids — Shop GrandStart.ru 🌟"}}, {"audio_id": "fgybHElWp0g", "text": {"fgybHElWp0g-00000-00000254-00000454": "Do you know what this is, everyone?", "fgybHElWp0g-00001-00000454-00000590": "Soccer ball?", "fgybHElWp0g-00002-00000590-00000682": "A soccer ball?", "fgybHElWp0g-00003-00000682-00000842": "Did we get a soccer ball?", "fgybHElWp0g-00004-00001738-00002372": "We have received the Choice Award at the AAA.", "fgybHElWp0g-00005-00002450-00002994": "We're so happy to have received an award at AAA for the second year in a row.", "fgybHElWp0g-00006-00003060-00003715": "Representing Korea today alongside top stars has been an honor.", "fgybHElWp0g-00007-00003740-00004282": "We are so happy to have been given this Choice Award.", "fgybHElWp0g-00008-00004286-00004534": "We are honored and thankful.", "fgybHElWp0g-00009-00004534-00004680": "So we can rise higher", "fgybHElWp0g-00010-00004794-00005064": "We'll become more hardworking as Snuper.", "fgybHElWp0g-00011-00005120-00005482": "Going forward, we'll put in a lot of effort, so please cheer for us.", "fgybHElWp0g-00012-00005482-00005786": "We love you Swings!", "fgybHElWp0g-00013-00005788-00005904": "Love you!", "fgybHElWp0g-00014-00006034-00006338": "Until now, it's been Snuper! Thank you!"}}, {"audio_id": "fgTrkIiPqlk", "text": {"fgTrkIiPqlk-00000-00000060-00000146": "Hi.", "fgTrkIiPqlk-00001-00000146-00000723": "This video was prepared using the Lightning interface on the salesforce.com demo account.", "fgTrkIiPqlk-00002-00000723-00001140": "Depending on the license types your company uses, customizations made,", "fgTrkIiPqlk-00003-00001140-00001830": "and whether the interface you use is Lightning or Salesforce Classic, the screenshots may differ.", "fgTrkIiPqlk-00004-00001830-00002170": "The subject of this video is to reset the security token.", "fgTrkIiPqlk-00005-00002201-00002618": "Click on your profile photo and select the “Settings” link.", "fgTrkIiPqlk-00006-00002704-00003058": "You can select “Reset security token” from the left menu,", "fgTrkIiPqlk-00007-00003058-00003535": "or you can access this option by typing the keyword in the search box.", "fgTrkIiPqlk-00008-00003566-00004026": "On the page that is opened, click ¨Reset security token¨ button.", "fgTrkIiPqlk-00009-00004026-00004555": "Your email address to which your account is linked will now have your new security token.", "fgTrkIiPqlk-00010-00004555-00004746": "Thanks for watching."}}, {"audio_id": "fgWqH0Nuf6y", "text": {"fgWqH0Nuf6y-00000-00000030-00000544": "Apparently, this is the point we’ve reached in human history — expensive lollies parading", "fgWqH0Nuf6y-00001-00000544-00000668": "as vitamins.", "fgWqH0Nuf6y-00002-00000668-00000956": "My wife bought these just the other day to give to our children.", "fgWqH0Nuf6y-00003-00000956-00001420": "To be fair to her, they were on special at less than half-price, and English isn’t", "fgWqH0Nuf6y-00004-00001420-00001760": "her first language, so I can understand the confusion.", "fgWqH0Nuf6y-00005-00001760-00002118": "“Vita Gummies, Multi-Vitamin + Vegies”.", "fgWqH0Nuf6y-00006-00002118-00002254": "Here’s what they look like.", "fgWqH0Nuf6y-00007-00002254-00002554": "“Sir, would you like some vitamins with your sugar?”.", "fgWqH0Nuf6y-00008-00002554-00003000": "Yes, that pile of sugar that you see in front of you is apparently a multi-vitamin.", "fgWqH0Nuf6y-00009-00003000-00003492": "Of course, my children love them, which I personally think is a huge problem.", "fgWqH0Nuf6y-00010-00003492-00003897": "If they ever got hold of them when I’m not around, they would almost certainly feast", "fgWqH0Nuf6y-00011-00003897-00004424": "upon them consuming an uncontrolled amount of supplemental nutrients in the process.", "fgWqH0Nuf6y-00012-00004424-00004946": "The only hint that they contain ANY sugar is this little two-word phrase hidden on the", "fgWqH0Nuf6y-00013-00004946-00005212": "back — “Contains sugars”.", "fgWqH0Nuf6y-00014-00005212-00005653": "There’s no other evidence apart from the pile of sugar coated on the outside of each", "fgWqH0Nuf6y-00015-00005653-00005740": "gummy.", "fgWqH0Nuf6y-00016-00005740-00006100": "Every other product in Australia has to show their sugar content.", "fgWqH0Nuf6y-00017-00006100-00006362": "Apparently vitamins are exempt from this.", "fgWqH0Nuf6y-00018-00006362-00006698": "These so-called vitamins claim to contain veggies.", "fgWqH0Nuf6y-00019-00006698-00007284": "Looking on the back, we can see that there are 5mg each of spinach, carrot, beetroot,", "fgWqH0Nuf6y-00020-00007284-00007442": "and artichoke.", "fgWqH0Nuf6y-00021-00007442-00007934": "Remembering what 5mg is — 1/200th of a gram.", "fgWqH0Nuf6y-00022-00007934-00008095": "I mean, what is that?", "fgWqH0Nuf6y-00023-00008095-00008662": "According to Google, the average pea weighs between 100 and 360 milligrams.", "fgWqH0Nuf6y-00024-00008662-00009150": "That means that a single solitary pea has about 10 times as many vegetables in it than", "fgWqH0Nuf6y-00025-00009150-00009338": "does one of these vita gummies.", "fgWqH0Nuf6y-00026-00009338-00009448": "Hmm.", "fgWqH0Nuf6y-00027-00009448-00009928": "Even these vegetable-flavoured stock cubes that I picked up from Aldi have more vegetables", "fgWqH0Nuf6y-00028-00009928-00010016": "in them.", "fgWqH0Nuf6y-00029-00010016-00010348": "Maybe you should be feeding your children stock cubes instead.", "fgWqH0Nuf6y-00030-00010348-00010558": "I’m sure they would be a lot healthier.", "fgWqH0Nuf6y-00031-00010558-00010780": "Anyway, that’s my little rant for today.", "fgWqH0Nuf6y-00032-00010780-00011249": "If my sarcasm wasn’t glaringly obvious, whatever you do, please don’t feed your", "fgWqH0Nuf6y-00033-00011249-00011647": "children stock cubes, and certainly while you’re at it, you probably shouldn’t be", "fgWqH0Nuf6y-00034-00011647-00011865": "feeding them Vita Gummies either.", "fgWqH0Nuf6y-00035-00011866-00012230": "Now I guess it’s time for me to go and prepare for the incoming lawsuit.", "fgWqH0Nuf6y-00036-00012230-00012302": "Peace."}}, {"audio_id": "fh8wlR1c_lY", "text": {"fh8wlR1c_lY-00000-00000000-00000258": "If you make push-ups part of your daily routine,", "fh8wlR1c_lY-00001-00000258-00000570": "there are a few things you can expect to happen to your body.", "fh8wlR1c_lY-00002-00000768-00001380": "First of all, your strength and endurance will increase significantly. You'll be able to lift", "fh8wlR1c_lY-00003-00001380-00002052": "heavier weights and do more reps with ease. You'll also develop better posture and balance,", "fh8wlR1c_lY-00004-00002052-00002550": "since push-ups help to strengthen the core muscles that keep your body upright and stable.", "fh8wlR1c_lY-00005-00002820-00003318": "Additionally, your muscles will become more toned, and you'll have a more defined physique.", "fh8wlR1c_lY-00006-00003414-00004061": "Lastly, push-ups can help to reduce stress and improve your overall mood. So, if you're looking", "fh8wlR1c_lY-00007-00004061-00004566": "to get in shape and feel better, push-ups are definitely worth adding to your daily routine.", "fh8wlR1c_lY-00008-00004740-00005322": "In addition to the physical benefits, push-ups can also have a positive impact on your mental health.", "fh8wlR1c_lY-00009-00005568-00006156": "Studies have shown that regular exercise, such as push-ups, can reduce stress, improve sleep,", "fh8wlR1c_lY-00010-00006156-00006773": "and even enhance cognitive function. So, if you're looking for an effective way to", "fh8wlR1c_lY-00011-00006773-00007206": "reduce stress and improve your overall wellbeing, push-ups are a great choice.", "fh8wlR1c_lY-00012-00007523-00008016": "Plus, it only takes about 10 minutes a day to get the benefits, making it easy", "fh8wlR1c_lY-00013-00008016-00008544": "to fit into your daily routine. Push-ups also have some important health benefits. They can", "fh8wlR1c_lY-00014-00008544-00009066": "help to strengthen your bones, improve your cardiovascular health, and even reduce your", "fh8wlR1c_lY-00015-00009066-00009876": "risk of developing certain diseases. Plus, they can help to improve your flexibility and agility,", "fh8wlR1c_lY-00016-00009876-00010380": "so you'll be better able to move and perform everyday activities with ease. So,", "fh8wlR1c_lY-00017-00010380-00010794": "if you want to get healthier and feel better, push-ups are a great way to do it.", "fh8wlR1c_lY-00018-00010878-00011376": "And, with just 10 minutes a day, it's easy to fit into your schedule. To get the most", "fh8wlR1c_lY-00019-00011376-00011862": "out of your push-up routine, it's important to practice good form. Make sure your hands are", "fh8wlR1c_lY-00020-00011862-00012348": "directly under your shoulders and your body is in a straight line from head to toe. Additionally,", "fh8wlR1c_lY-00021-00012348-00012900": "keep your core tight and your back straight. And, be sure to lower yourself slowly and with control.", "fh8wlR1c_lY-00022-00012900-00013518": "If you're just starting out, it's also a good idea to start with modified push-ups and gradually work", "fh8wlR1c_lY-00023-00013518-00014034": "your way up to full push-ups. This will help you build strength and prevent injury. Overall,", "fh8wlR1c_lY-00024-00014034-00014562": "push-ups are a great way to stay in shape and improve your overall health and wellbeing. With", "fh8wlR1c_lY-00025-00014562-00015072": "just 10 minutes a day, you can get all of the benefits of push-ups, from increased strength", "fh8wlR1c_lY-00026-00015072-00015576": "and endurance to improved mental health and reduced stress. So, if you're looking for an", "fh8wlR1c_lY-00027-00015576-00016158": "effective way to get in shape and feel better, give push-ups a try. You won't regret it!"}}, {"audio_id": "fhFq8vHtI7E", "text": {"fhFq8vHtI7E-00000-00002164-00002747": "Extrasensory is built on humanity's two main interests: ourselves and the future.", "fhFq8vHtI7E-00001-00002747-00003202": "What it means for us to collectively make our way in and understand the world,", "fhFq8vHtI7E-00002-00003202-00003727": "and where we're going, and how science might take us there.", "fhFq8vHtI7E-00003-00003930-00004703": "Welcome to Extrasensory! Tonight is all about our sensory potential. What could", "fhFq8vHtI7E-00004-00004703-00005843": "our senses really, truly be with a little bit of help from science? At Extrasensory", "fhFq8vHtI7E-00005-00005843-00006340": "we explored the future of human perception. We considered how our senses", "fhFq8vHtI7E-00006-00006340-00006770": "work together to create a picture of the world and how we are sometimes tricked", "fhFq8vHtI7E-00007-00006770-00007244": "by our senses so that this picture can, in fact, be quite different to reality.", "fhFq8vHtI7E-00008-00007244-00007775": "Without our sense of sight and smell, we struggle to taste the difference between", "fhFq8vHtI7E-00009-00007775-00008288": "tea and coffee. Hearing sounds affects how we taste chocolate and how we place", "fhFq8vHtI7E-00010-00008288-00008831": "pressure on the bottom of our feet as we walk. Whether we seek knowledge in the", "fhFq8vHtI7E-00011-00008831-00009400": "music or stories we listen to, or conduct experiments for ourselves, and on", "fhFq8vHtI7E-00012-00009400-00009992": "ourselves, we find the limits of our own perception and discover how these might", "fhFq8vHtI7E-00013-00009992-00010655": "be enhanced or augmented in the future. Instruments, AI and wearables are here,", "fhFq8vHtI7E-00014-00010655-00011802": "and many more are coming to make the unperceivable perceivable. We", "fhFq8vHtI7E-00015-00011802-00012240": "can award ourselves sensory capacity, inspired by the special abilities of", "fhFq8vHtI7E-00016-00012240-00012849": "amazing, non-human animals and insects and become consciously aware of the", "fhFq8vHtI7E-00017-00012849-00013512": "information previously only available to our unconscious. Our visual sense tends", "fhFq8vHtI7E-00018-00013512-00014034": "to heavily dominate. We build our world around sight. We try to see further using", "fhFq8vHtI7E-00019-00014034-00014568": "microscopes, telescopes and other specialised instruments, but we have all", "fhFq8vHtI7E-00020-00014568-00015180": "this other sensory capacity. We can hear genetic variability, not just see it. We", "fhFq8vHtI7E-00021-00015180-00015647": "can feel our way with our fingers to understand the immune system, or find our", "fhFq8vHtI7E-00022-00015647-00016185": "way inside a building. We can feel where we are in space rather than just see it,", "fhFq8vHtI7E-00023-00016185-00016917": "and we smell and taste a great beer or a fine wine. Extrasensory asks: \"what if the", "fhFq8vHtI7E-00024-00016917-00017373": "trick to furthering our capabilities is in part learning to refocus our", "fhFq8vHtI7E-00025-00017373-00017945": "attention on utilising all our senses together to their full capacity?\"", "fhFq8vHtI7E-00026-00017945-00018443": "In the future we will probably all be left wondering how we have survived", "fhFq8vHtI7E-00027-00018443-00019084": "without these scientific, extrasensory perceptions."}}, {"audio_id": "firl0j9beLc", "text": {"firl0j9beLc-00000-00000003-00000500": "hi I'm mark with the North Shore commercial door com I want to introduce", "firl0j9beLc-00001-00000500-00001092": "you today to one of our suppliers and the suppliers Sears craftsman this is an", "firl0j9beLc-00002-00001092-00001725": "interesting introduction because Sears craftsman for many many years was the", "firl0j9beLc-00003-00001725-00002465": "in-house brand that Sears sold and in 2017 Sears sold the craftsman brand to", "firl0j9beLc-00004-00002465-00003132": "Stanley Black & Decker and Sears craftsman is still sold in Sears stores", "firl0j9beLc-00005-00003132-00003686": "but you'll see the craftsman showing up in more and more of the home stores and", "firl0j9beLc-00006-00003686-00004467": "other venues in retail today they make for our industry garage door openers and", "firl0j9beLc-00007-00004467-00004917": "related controls they're state-of-the-art they've always done a", "firl0j9beLc-00008-00004917-00005519": "good job and we're glad to say that we can get parts for anything they make and", "firl0j9beLc-00009-00005519-00006312": "we have a lot of knowledge and we'll take good care of you thank you for", "firl0j9beLc-00010-00006312-00006693": "watching this video from Northshore commercial door com please subscribe to", "firl0j9beLc-00011-00006693-00007238": "our channel so we can continue to make content like this thank you", "firl0j9beLc-00012-00007540-00007745": "you"}}, {"audio_id": "fjmef6EkS_u", "text": {"fjmef6EkS_u-00000-00000000-00004100": "🌟 🇺🇸 SUIT CUSTOMER FEMALE — Shop GrandStart.ru 🌟"}}, {"audio_id": "fjzND1kYDuQ", "text": {"fjzND1kYDuQ-00000-00000006-00000429": "the higher level of intelligence the more accountability the more", "fjzND1kYDuQ-00001-00000429-00000882": "responsibility but when you start dividing and the division just breaks it", "fjzND1kYDuQ-00002-00000882-00001388": "all the way down so that's that's part of it and I think that you know Portland", "fjzND1kYDuQ-00003-00001388-00001902": "Portland is a Portland is a follower city welcome back this is Big D that it", "fjzND1kYDuQ-00004-00001902-00002232": "again this episode is going to be more like the street life and the things", "fjzND1kYDuQ-00005-00002232-00002649": "that's going on and people in gangs and drugs of money and women and everything", "fjzND1kYDuQ-00006-00002649-00002949": "else like that and how people leading their lives and getting to where they", "fjzND1kYDuQ-00007-00002949-00003357": "got and why they are where they are today that our remember first came up", "fjzND1kYDuQ-00008-00003357-00003834": "here out of LA that was doing gains in the early 80s and everybody was shook", "fjzND1kYDuQ-00009-00003834-00004496": "like what gangs was no gang like what and in like I said then you start", "fjzND1kYDuQ-00010-00004496-00004959": "dividing guys up that was cool and you start to see more and more people", "fjzND1kYDuQ-00011-00004959-00005432": "picking sides and separate themselves and then you started to see mortars", "fjzND1kYDuQ-00012-00005432-00005751": "shootings you start to see more than dropping out of high school because we", "fjzND1kYDuQ-00013-00005751-00006203": "was in high school this is freshman year right cats jumping", "fjzND1kYDuQ-00014-00006203-00006686": "in gangs in eighth grade and in freshman year and then before you know it they're", "fjzND1kYDuQ-00015-00006686-00007484": "out of completely my sophomore year that's my I see that's part of the", "fjzND1kYDuQ-00016-00007484-00007950": "decision-making process when you choose to do anything and you start making", "fjzND1kYDuQ-00017-00007950-00008622": "grown-up decisions you you start making decisions more more you know saying", "fjzND1kYDuQ-00018-00008622-00009122": "sometimes your decisions aren't the best decisions and you know people's this is", "fjzND1kYDuQ-00019-00009122-00009354": "a thing there's a lot of people they weren't gangs that were intelligent", "fjzND1kYDuQ-00020-00009354-00009702": "people and there are in games that are intelligent people there's a lot of", "fjzND1kYDuQ-00021-00009702-00010122": "businessmen because you know what people don't realize is these fortune 500", "fjzND1kYDuQ-00022-00010122-00010697": "companies are gangs you know saying these businesses the government the law", "fjzND1kYDuQ-00023-00010697-00011172": "enforcement these are all organizations these are all gangs it's the same thing", "fjzND1kYDuQ-00024-00011172-00011778": "you I mean the America was built on organizations and gangs imported", "fjzND1kYDuQ-00025-00011778-00012107": "something there's nobody that that has been", "fjzND1kYDuQ-00026-00012107-00012699": "successful in life that hasn't been part of an organization you know whether it's", "fjzND1kYDuQ-00027-00012699-00013098": "Nabisco whether it's Apple these are organizations", "fjzND1kYDuQ-00028-00013098-00013629": "you know saying that go places take over places implement their plan it's the", "fjzND1kYDuQ-00029-00013629-00014106": "same as anything it's just like in the drug deals you get your money right and", "fjzND1kYDuQ-00030-00014106-00014554": "he had this house over here you buy up that house done now it's your house", "fjzND1kYDuQ-00031-00014554-00014865": "right you know you basically gone and they do that with these companies they", "fjzND1kYDuQ-00032-00014865-00015206": "take a big company buy out all the small companies and then they just become the", "fjzND1kYDuQ-00033-00015206-00015720": "monopolize the whole market or whatever they doing it's the same thing it's all", "fjzND1kYDuQ-00034-00015720-00016170": "the same thing it's it's just business it's doing", "fjzND1kYDuQ-00035-00016170-00016603": "business and people that do business usually do business in their", "fjzND1kYDuQ-00036-00016603-00017278": "organizations and so this is what was shown to us and given to us but it also", "fjzND1kYDuQ-00037-00017278-00017781": "was given to us as a means of division because if you take a hundred people and", "fjzND1kYDuQ-00038-00017781-00018288": "you split that group of people into two groups you got two groups of 50 and then", "fjzND1kYDuQ-00039-00018288-00018810": "you put them at odds with each other and then conflict causes you know I'm saying", "fjzND1kYDuQ-00040-00018810-00019215": "whatever it causes and then instead of a hundred people standing there strong you", "fjzND1kYDuQ-00041-00019215-00019594": "have two groups of 50 they have a conflict between the two of them and you", "fjzND1kYDuQ-00042-00019594-00020140": "know anytime you have conflict you have casualty yeah whether it's death or", "fjzND1kYDuQ-00043-00020140-00020607": "whether it's prison or whether it's somebody being maimed whatever it is or", "fjzND1kYDuQ-00044-00020607-00021282": "mental or spiritual you have casualties I've seen a lot of the you say mental I", "fjzND1kYDuQ-00045-00021282-00021741": "seen a lot of depression going with a lot of people from trying to make it", "fjzND1kYDuQ-00046-00021741-00022116": "trying to show they stuff on YouTube trying to make it into music trying to", "fjzND1kYDuQ-00047-00022116-00022587": "make it in whatever market they're doing and it ain't happening fast enough", "fjzND1kYDuQ-00048-00022587-00022941": "because everybody want anything right now you want everything so fast and so", "fjzND1kYDuQ-00049-00022941-00023343": "since they can't obtain those things they get more depressed and feel like", "fjzND1kYDuQ-00050-00023343-00023904": "failures faster than back in the day you have to work harder they have the things", "fjzND1kYDuQ-00051-00023904-00024423": "with kids Oh everybody get a trophy now you know there's no loser yeah you know", "fjzND1kYDuQ-00052-00024423-00024840": "but we grew up know your loser we're gonna tell you as a loser and then", "fjzND1kYDuQ-00053-00024840-00025237": "you gonna get your stuff together to become a winner right and now you see", "fjzND1kYDuQ-00054-00025237-00025641": "everybody like oh you know depression that is all-time high everybody's I'm", "fjzND1kYDuQ-00055-00025641-00026208": "depressed for these reasons and I can't make it and I can't do this and vs1 know", "fjzND1kYDuQ-00056-00026208-00026563": "I need to figure it out I need to Carter and get some money in my corner", "fjzND1kYDuQ-00057-00026563-00027247": "to teach me what I need to do to make it well part of part of losing and part of", "fjzND1kYDuQ-00058-00027247-00027708": "accepting a loss because there there's no winning without losing it's going to", "fjzND1kYDuQ-00059-00027708-00028288": "be rare where you find somebody that's won their whole life losing is a way to", "fjzND1kYDuQ-00060-00028288-00028833": "have a good understanding for what you need to do to win you know so I think", "fjzND1kYDuQ-00061-00028833-00029344": "that then understanding pretty well yeah exactly if you can understand losing", "fjzND1kYDuQ-00062-00029344-00029662": "then you should never probably understand winning mm-hmm and I think", "fjzND1kYDuQ-00063-00029662-00030345": "that when it comes to you know that everybody no one's a loser in life", "fjzND1kYDuQ-00064-00030345-00030838": "there's that's not really life there's gonna be people that lose because if you", "fjzND1kYDuQ-00065-00030838-00031302": "play sports somebody really loses if you if you are", "fjzND1kYDuQ-00066-00031302-00031797": "living life sometimes you're gonna take losses but I think that more or less it", "fjzND1kYDuQ-00067-00031797-00032319": "helps you understand the things that you shouldn't do or the things you should", "fjzND1kYDuQ-00068-00032319-00032800": "adjust so that you can get yourself in position losing should make you", "fjzND1kYDuQ-00069-00032800-00033193": "understand what you don't want to do so that you can understand you learn more", "fjzND1kYDuQ-00070-00033193-00033669": "what you do need to do mm-hmm so if you say at the end of the time I", "fjzND1kYDuQ-00071-00033669-00033996": "should have shot the shot I didn't shoot the shot and we lost", "fjzND1kYDuQ-00072-00033996-00034365": "next time you'll say you know what I'm gonna take the shot next time and it's", "fjzND1kYDuQ-00073-00034365-00034759": "about positioning in life life is about positioning it's just people are", "fjzND1kYDuQ-00074-00034759-00035200": "responsible for where they're at in life but I think that a lot of people don't", "fjzND1kYDuQ-00075-00035200-00035599": "want to accept responsibility for their positioning in life but position the", "fjzND1kYDuQ-00076-00035599-00035946": "thing about position is you can do things to change your position you can", "fjzND1kYDuQ-00077-00035946-00036375": "do things to help other people in their situation to give them better position", "fjzND1kYDuQ-00078-00036375-00036819": "and that goes along with the division the more divided we are the less", "fjzND1kYDuQ-00079-00036819-00037203": "opportunity that we're going to have amongst us to share things because other", "fjzND1kYDuQ-00080-00037203-00037578": "races that I've noticed they share with each other there's support early room", "fjzND1kYDuQ-00081-00037578-00038034": "yeah I'm saying they support and share we don't we have that bad in our reign", "fjzND1kYDuQ-00082-00038034-00038506": "you looked at you know a lot of stores you go you got arrested store you get", "fjzND1kYDuQ-00083-00038506-00039165": "Asian stores like big stores and if you go in there it's gonna be like 85% to", "fjzND1kYDuQ-00084-00039165-00039831": "90% of Russians in there Asians in there CNN's in their in their stores yeah and", "fjzND1kYDuQ-00085-00039831-00040299": "if you go into a black store it's going to be either empty or a couple black", "fjzND1kYDuQ-00086-00040299-00040766": "folks in there and predominately some other culture you know in so we don't", "fjzND1kYDuQ-00087-00040766-00041124": "see that support you're talking about money you know we talked about before", "fjzND1kYDuQ-00088-00041124-00041549": "money to hit your circle seven times before lead so you can all make some", "fjzND1kYDuQ-00089-00041549-00042090": "money and then if I buy what you buy and and we support each other we can keep", "fjzND1kYDuQ-00090-00042090-00042538": "making money but we typically go oh no I can't he can't", "fjzND1kYDuQ-00091-00042538-00043088": "hook me up slain shopping with him yes its programming when you go into", "fjzND1kYDuQ-00092-00043088-00043544": "Louboutins you go to Gucci you go to Levi's you go to any of these companies", "fjzND1kYDuQ-00093-00043544-00043913": "you wouldn't dare go in there and ask for a deal that's understood already", "fjzND1kYDuQ-00094-00043913-00044156": "right but when you go deal with two people", "fjzND1kYDuQ-00095-00044156-00044837": "you want them to devalue they product so that you can be happy it's part of the", "fjzND1kYDuQ-00096-00044837-00045390": "it's part of what they they they put this in us a long time ago to fit the", "fjzND1kYDuQ-00097-00045390-00045852": "value you know saying if we're sitting there do value in each other then we say", "fjzND1kYDuQ-00098-00045852-00046311": "well I have a product and instead of selling my product for 15 hours I'm", "fjzND1kYDuQ-00099-00046311-00046871": "gonna sell it for 30 when Louis Vuitton is selling a shirt for 800 and we have", "fjzND1kYDuQ-00100-00046871-00047256": "no problem going to another race which in a lot of these races don't even", "fjzND1kYDuQ-00101-00047256-00047690": "respect us don't even really want to wear and they're there their clothing or", "fjzND1kYDuQ-00102-00047690-00048038": "no they want to some they want us in their store because they want our money", "fjzND1kYDuQ-00103-00048038-00048509": "black people is pretty much that almost the biggest consumer on the planet we", "fjzND1kYDuQ-00104-00048509-00049016": "consume most of all the things we just don't get paid for being black you know", "fjzND1kYDuQ-00105-00049016-00049500": "I'm saying other races take everything from us they appropriated and then they", "fjzND1kYDuQ-00106-00049500-00049988": "sell it back to us and we don't we don't know how to support each other we find", "fjzND1kYDuQ-00107-00049988-00050546": "issues in supporting each other but we have no problem supporting other brands", "fjzND1kYDuQ-00108-00050546-00051008": "but it's just something that's been that we have dealt with for a long time and", "fjzND1kYDuQ-00109-00051008-00051392": "it's part of the division once again is part of us being divided amongst each", "fjzND1kYDuQ-00110-00051392-00051951": "other we see value and other things that are not us mm-hmm when the value that", "fjzND1kYDuQ-00111-00051951-00052186": "they have they from us anything right in the first", "fjzND1kYDuQ-00112-00052186-00052692": "place right is are they laying out tanning when putting the stuff it's", "fjzND1kYDuQ-00113-00052692-00053283": "braked in and by you name it Trinity be you know your color and everything else", "fjzND1kYDuQ-00114-00053283-00053838": "the old music trying to dress like you every why why you don't get on they", "fjzND1kYDuQ-00115-00053838-00054279": "don't look good I mean it's his life you know I'm saying the one thing about it", "fjzND1kYDuQ-00116-00054279-00054795": "is is this life that we live the things are gonna be haven't going to be the way", "fjzND1kYDuQ-00117-00054795-00055176": "that you can make that change is you know sitting down with your people and", "fjzND1kYDuQ-00118-00055176-00055636": "you know put a plan together to where you say listen we gonna spend this money", "fjzND1kYDuQ-00119-00055636-00056050": "in our community because other races do that this understood already it's not", "fjzND1kYDuQ-00120-00056050-00056463": "understand with us but then again you have to think about it we live in this", "fjzND1kYDuQ-00121-00056463-00057033": "is this is Portland you can't name you can't name five black developers in the", "fjzND1kYDuQ-00122-00057033-00057444": "city you can't name we don't have any nightclubs that are owned by black", "fjzND1kYDuQ-00123-00057444-00057901": "people we don't have any black sports bars we don't have anything for us so", "fjzND1kYDuQ-00124-00057901-00058435": "when people don't allow you and you don't put yourself in position to have", "fjzND1kYDuQ-00125-00058435-00058951": "these things there's a mental block that gets in there yes you know because", "fjzND1kYDuQ-00126-00058951-00059454": "that's that's what we deal with there's nowhere for us to go when we do go", "fjzND1kYDuQ-00127-00059454-00059976": "places it is to spend money with other cultures when you go out to eat we have", "fjzND1kYDuQ-00128-00059976-00060333": "we have one thing we have we have some black businessmen to do business and", "fjzND1kYDuQ-00129-00060333-00060819": "they sell food but we don't have too many black restaurants you can't really", "fjzND1kYDuQ-00130-00060819-00061377": "name me ten black restaurants we are in a major metropolitan city there's no way", "fjzND1kYDuQ-00131-00061377-00061770": "that we should not have ten black owned restaurants and I don't mean soul food", "fjzND1kYDuQ-00132-00061770-00062226": "I mean restaurants in general or here whatever I don't care if you black and", "fjzND1kYDuQ-00133-00062226-00062676": "you sell in Greek food right but they only buy black people in other places", "fjzND1kYDuQ-00134-00062676-00063361": "you have black patronage and you have black business going on but not here you", "fjzND1kYDuQ-00135-00063361-00063941": "can't name black 10 black restaurants here you can't you can't name ten black", "fjzND1kYDuQ-00136-00063941-00064431": "clothing stores here you can't name none of these high-rises", "fjzND1kYDuQ-00137-00064431-00064920": "that they keep putting up are owned by black people you upset and so it's like", "fjzND1kYDuQ-00138-00064920-00065266": "when are we gonna get together and say you know I don't care if you get twenty", "fjzND1kYDuQ-00139-00065266-00065549": "black people to get we're gonna put 20 bands again are we", "fjzND1kYDuQ-00140-00065549-00065906": "gonna buy a property and we gonna develop it yeah we gonna it's gonna get", "fjzND1kYDuQ-00141-00065906-00066479": "cut 20 ways but there's still a profit in there mm-hmm that's what we don't do", "fjzND1kYDuQ-00142-00066479-00067031": "we don't do it and a few the few of us that might be doing it they not bringing", "fjzND1kYDuQ-00143-00067031-00067418": "back the knowledge and I know they're gonna say why I try to help I try to", "fjzND1kYDuQ-00144-00067418-00067712": "tell people don't nobody want to listen and the people who they're talking about", "fjzND1kYDuQ-00145-00067712-00068011": "don't want to listen they're gonna say ain't nobody bringing the knowledge back", "fjzND1kYDuQ-00146-00068011-00068498": "somebody has to do something yeah I mean and we because the thing about it was", "fjzND1kYDuQ-00147-00068498-00068882": "like I say anything that we put our heart into it we're good at if we decide", "fjzND1kYDuQ-00148-00068882-00069211": "that we want to run the streets and we want to kill each other we good at that", "fjzND1kYDuQ-00149-00069211-00069746": "but the thing about it is people out here killing for nothing but they won't", "fjzND1kYDuQ-00150-00069746-00070241": "kill for something like you let these racist groups come to your city yo you", "fjzND1kYDuQ-00151-00070241-00070574": "don't touch them they're on their head but you gonna kill somebody you went to", "fjzND1kYDuQ-00152-00070574-00071045": "school with some cases you killing one your own family members literally but", "fjzND1kYDuQ-00153-00071045-00071429": "you not willing to say you know what it's easier to people to pick up a gun", "fjzND1kYDuQ-00154-00071429-00071993": "and do whatever you do it's easy to join the organization it's easy to be with", "fjzND1kYDuQ-00155-00071993-00072542": "and make decisions based upon a thought process but the same way you do that is", "fjzND1kYDuQ-00156-00072542-00072899": "the same way you can say you know what I'm gonna do business with these people", "fjzND1kYDuQ-00157-00072899-00073232": "and we're gonna put something together and we're gonna get a package together", "fjzND1kYDuQ-00158-00073232-00073625": "and we're gonna bribe property or we gonna open businesses together I don't", "fjzND1kYDuQ-00159-00073625-00073886": "care if it's ten y'all y'all say you know what we all gonna get the money", "fjzND1kYDuQ-00160-00073886-00074237": "together we all open up a restaurant it's hard for us to get on the same page", "fjzND1kYDuQ-00161-00074237-00074582": "with each other but you have these other cultures that", "fjzND1kYDuQ-00162-00074582-00074953": "are on the same page with you with each other and they're in there and they're", "fjzND1kYDuQ-00163-00074953-00075359": "progressing they're prosperous they're eating they're having money you know I", "fjzND1kYDuQ-00164-00075359-00075743": "mean we don't never have any events where there's because this just isn't", "fjzND1kYDuQ-00165-00075743-00076349": "the young cats this isn't the cats that are 14 15 18 25 this ages them this is", "fjzND1kYDuQ-00166-00076349-00076907": "older cats that are 30 35 and beyond but what kind of wrapping it up for a", "fjzND1kYDuQ-00167-00076907-00077363": "second kind of where we started from is getting the money in the street life", "fjzND1kYDuQ-00168-00077363-00077822": "everything else and then it goes all the way full circle back up to that now", "fjzND1kYDuQ-00169-00077822-00078350": "where adults should be owning these things but a lot of that started and is", "fjzND1kYDuQ-00170-00078350-00078790": "now possibly because it didn't happen here right as a child you didn't", "fjzND1kYDuQ-00171-00078790-00079325": "but there was nobody making you strive to get to there because the introduction", "fjzND1kYDuQ-00172-00079325-00079700": "so they don't believe that it's possible that they should own those things nor", "fjzND1kYDuQ-00173-00079700-00080267": "should have you know that fancy car that's not just cutlets on some rims", "fjzND1kYDuQ-00174-00080267-00080867": "yeah you know a really nice you know car that's everybody go my god you don't", "fjzND1kYDuQ-00175-00080867-00081302": "have to put a rims on it but it's seeing it believe it when you're not seeing it", "fjzND1kYDuQ-00176-00081302-00081746": "you gonna have a hard time believing it you know when I say you don't see ten", "fjzND1kYDuQ-00177-00081746-00082217": "black businesses when they don't see it they don't believe it so if I don't see", "fjzND1kYDuQ-00178-00082217-00082685": "somebody like myself doing it then why would I try to do that when I see people", "fjzND1kYDuQ-00179-00082685-00083111": "like me doing certain things and that looks like that's the norm it's easier", "fjzND1kYDuQ-00180-00083111-00083483": "to lend myself to that type of stuff whatever that may be we're gonna be", "fjzND1kYDuQ-00181-00083483-00084164": "wrapping this up here in a second anyway but all I want to do if you can reach", "fjzND1kYDuQ-00182-00084164-00084620": "out to somebody in the camera and say hey this is possible you can do it if", "fjzND1kYDuQ-00183-00084620-00085010": "you do these certain things give somebody some life and preach them", "fjzND1kYDuQ-00184-00085010-00085499": "something good I mean anything you want to do you can do I think one of the", "fjzND1kYDuQ-00185-00085499-00086069": "biggest things that I notice is I must speak on my culture we we like we learn", "fjzND1kYDuQ-00186-00086069-00086480": "to do things and we love things when we're young the things that you love as", "fjzND1kYDuQ-00187-00086480-00086846": "a child some of those things you can be successful doing I think you just need", "fjzND1kYDuQ-00188-00086846-00087428": "to be true to yourself and be you are and and be a leader it's easy to follow", "fjzND1kYDuQ-00189-00087428-00087878": "what other people do it's hard to be a leader you know and a lot of us are", "fjzND1kYDuQ-00190-00087878-00088172": "fearful to take a step out there by ourselves", "fjzND1kYDuQ-00191-00088172-00088763": "but if you feel fear taking a step out there by yourself usually the step that", "fjzND1kYDuQ-00192-00088763-00089237": "you want to take is going to be for advantage so take the step and try", "fjzND1kYDuQ-00193-00089237-00089612": "something and understand in the world you go by you came here by yourself and", "fjzND1kYDuQ-00194-00089612-00089951": "you're gonna leave by yourself so sometimes you have to stand alone for", "fjzND1kYDuQ-00195-00089951-00090506": "your success that's good definitely most definitely I'll believe area thing like", "fjzND1kYDuQ-00196-00090506-00090704": "that you see a lot of people are trying to do", "fjzND1kYDuQ-00197-00090704-00091145": "stuff and they scare they scare somebody going to talk negative about to them", "fjzND1kYDuQ-00198-00091145-00091573": "because they trying to be better better than lives you know I say", "fjzND1kYDuQ-00199-00091573-00092011": "this real quick I had some of my friends told me when I get out of jail man I'm", "fjzND1kYDuQ-00200-00092011-00092380": "gonna be a nerd like you because I was considered a nerd because I wasn't doing", "fjzND1kYDuQ-00201-00092380-00092830": "some of the things so that wasn't banging right and I wasn't smoking weed", "fjzND1kYDuQ-00202-00092830-00093226": "and all that stuff so they know I'm a nerd you know but then they like well", "fjzND1kYDuQ-00203-00093226-00093598": "you come visit me I know when it came down to it I was the only one visiting", "fjzND1kYDuQ-00204-00093598-00094105": "them the ones they was in the street life with none of those dudes visit them", "fjzND1kYDuQ-00205-00094105-00094622": "right right none of those dudes put money on the books right but they call", "fjzND1kYDuQ-00206-00094622-00095107": "me and say hey can you do this and not do it so anyway stepping out on the lam", "fjzND1kYDuQ-00207-00095107-00095569": "is a good one and people need to do it more and realize like you said you step", "fjzND1kYDuQ-00208-00095569-00096043": "out there yeah you're out there alone for a second but when it come full", "fjzND1kYDuQ-00209-00096043-00096505": "circle everybody got your back cuz you win right you know everybody", "fjzND1kYDuQ-00210-00096505-00097063": "won't remember me remember me when I was you know yeah cuz you winning now sure", "fjzND1kYDuQ-00211-00097063-00097420": "everybody want to go remember me but the thing about winning is once you learn", "fjzND1kYDuQ-00212-00097420-00097843": "how to win you can show others how to win it's like fishing once you learn how", "fjzND1kYDuQ-00213-00097843-00098269": "to fish you could take that back to your people show them how to fish and now we", "fjzND1kYDuQ-00214-00098269-00098869": "all fish and we all eat anew it's multiplication you understand so now", "fjzND1kYDuQ-00215-00098869-00099280": "we're gonna wrap this up thanks for this episode if you haven't subscribed please", "fjzND1kYDuQ-00216-00099280-00099836": "subscribe please like and share hit the comment button in the bottom say what", "fjzND1kYDuQ-00217-00099836-00100366": "you got to say I'll get back to you thanks for watching"}}, {"audio_id": "fjEBTknE77y", "text": {"fjEBTknE77y-00000-00000019-00000459": "Your Natchez History Minute is brought to you by Natchez National Historical Park.", "fjEBTknE77y-00001-00000708-00001236": "Located 6 miles northeast of the city, the Natchez-Adams County Airport provides air", "fjEBTknE77y-00002-00001412-00002061": "access to Natchez, Adams County, and Southwest Mississippi. It is an all-weather, general", "fjEBTknE77y-00003-00002061-00002643": "aviation airport operating a Class IV Air Carrier certificate. The history of the airport", "fjEBTknE77y-00004-00002643-00003337": "dates back to 1946, when the land was received from the Corps of Engineers under the Defense", "fjEBTknE77y-00005-00003337-00003919": "for Land program for coastal defense. In the military style of the day, three runways were", "fjEBTknE77y-00006-00003919-00004555": "constructed. Today, two of those runways are in service. On this day, June 20 in 1959,", "fjEBTknE77y-00007-00004555-00005332": "the airfield was renamed and the terminal building dedicated to the honor of T. M. Hardy,", "fjEBTknE77y-00008-00005332-00006080": "Jr. and V. M. Anders, two men who were the first U. S. Airforce pilots from the community", "fjEBTknE77y-00009-00006080-00006564": "to lose their lives in World War II. Regarding the style of the terminal building, Flying", "fjEBTknE77y-00010-00006564-00007118": "Magazine asked “what other architectural pattern could those responsible for the design", "fjEBTknE77y-00011-00007118-00007726": "of an air terminal at Natchez employ than that of 30 or more ante-bellum homes in the", "fjEBTknE77y-00012-00007726-00008264": "immediate vicinity?” Beginning in the 1950s, Southern Airways operated scheduled airline", "fjEBTknE77y-00013-00008264-00009184": "service with Douglas DC-3 aircraft, switiching to Martin propliners in the 1970s. Trans-Texas", "fjEBTknE77y-00014-00009184-00009568": "Airways and Royale Airlines both served the Natchez airport.", "fjEBTknE77y-00015-00009568-00010178": "In December, 2003, the terminal building was named the Simmons Terminal Building in honor", "fjEBTknE77y-00016-00010178-00010756": "Billy Simmons, former director, and in memory of Helen Simmons for their years of dedicated", "fjEBTknE77y-00017-00010756-00010852": "service to the airport.", "fjEBTknE77y-00018-00013632-00014038": "Hi, I’m Bob Hawk Director of Aviation for the Natchez Adams County Airport and this", "fjEBTknE77y-00019-00014058-00014202": "has been your Natchez History Minute."}}, {"audio_id": "fjX8_9ffFVo", "text": {"fjX8_9ffFVo-00000-00000008-00000459": "SECRETARY OF THE NAVY RAY MABUS ISSUED AN UPDATED DEPARTMENT OF THE NAVY DIVERSITY AND", "fjX8_9ffFVo-00001-00000459-00000810": "INCLUSION POLICY STATEMENT, THE FIRST UPDATE SINCE TWENTY TEN.", "fjX8_9ffFVo-00002-00000810-00001257": "MABUS ALSO RELEASED A SHORT VIDEO HIGHLIGHTING DIVERSITY AND HOW THE NAVY AND MARINE CORPS", "fjX8_9ffFVo-00003-00001257-00001582": "ARE STRONGER WHEN THEY REFLECT THE NATION THEY SERVE.", "fjX8_9ffFVo-00004-00001582-00002052": "WE NEED DIVERSITY IN ALL SORTS OF THINGS, BUT MOSTLY WE NEED DIVERSITY OF THOUGHT.", "fjX8_9ffFVo-00005-00002052-00002548": "WE DON'T WANT EVERYBODY COMING INTO THE NAVY, COMING INTO THE MARINE CORPS, TO THINK EXACTLY THE SAME WAY.", "fjX8_9ffFVo-00006-00002548-00002836": "TO REMAIN THE GREATEST EXPEDITIONARY FIGHTING", "fjX8_9ffFVo-00007-00002836-00003306": "FORCE THE WORLD HAS EVER KNOWN, WHICH IS WHAT THE NAVY AND MARINE CORPS ARE TODAY,", "fjX8_9ffFVo-00008-00003306-00003808": "WE'VE GOT TO HAVE THAT DIVERSITY, WE'VE GOT TO HAVE THAT INCLUSIVENESS, WE'VE GOT TO BE ABLE", "fjX8_9ffFVo-00009-00003808-00004376": "TO RECRUIT THAT DIVERSITY. WE'VE GOT TO BE ABLE TO RETAIN THOSE GREAT", "fjX8_9ffFVo-00010-00004376-00005012": "SAILORS AND MARINES THAT WE GET HERE. AND ONE OF THE WAYS WE DO IT IS BY BEING INCLUSIVE", "fjX8_9ffFVo-00011-00005012-00005588": "AND BY MAKING THE FORCE MORE DIVERSE AND SO, STRONGER."}}, {"audio_id": "fk4rIZnVuyA", "text": {"fk4rIZnVuyA-00000-00000055-00000085": "*wind", "fk4rIZnVuyA-00001-00000085-00000222": "Hey guys, Rolando", "fk4rIZnVuyA-00002-00000648-00002280": "from ReveMoto. So today I'm going to be working on a 2016 Acura TLX passenger side mirror install.", "fk4rIZnVuyA-00003-00002280-00002790": "Well actually, I keep saying install, first we got to do a removal first and then installation", "fk4rIZnVuyA-00004-00002790-00003360": "of this 2016 TLX side view mirror. If you guys like this video, go ahead and like, subscribe,", "fk4rIZnVuyA-00005-00003360-00003834": "and turn on that push notification. And also, if you guys need this mirror for your vehicle go", "fk4rIZnVuyA-00006-00003834-00004302": "to ReveMoto.com, Your Pre-painted Auto Body Parts Source. Let's go ahead and get started. All right,", "fk4rIZnVuyA-00007-00004302-00004668": "so we got to take off a couple of screws. It's gonna be one right herec the door handlec and", "fk4rIZnVuyA-00008-00004668-00005172": "then one down there where the door handle actually is. That's the armrest I believe,", "fk4rIZnVuyA-00009-00005172-00005496": "yeah, right there. Let's go ahead and go to the armrest area first.", "fk4rIZnVuyA-00010-00005592-00005976": "All right if you guys look right in there, there's this cover right here. You're gonna", "fk4rIZnVuyA-00011-00005976-00006516": "need a flathead just like this one and put it right here on the side.", "fk4rIZnVuyA-00012-00006972-00007326": "I think maybe on this side, easier on this side.", "fk4rIZnVuyA-00013-00007578-00007722": "Let's go ahead and pull that out", "fk4rIZnVuyA-00014-00008130-00008472": "I actually just have to lift it up and it's going to be a screw= right there if", "fk4rIZnVuyA-00015-00008472-00008880": "you guys can see. Kind of holding it up with this thing, but let me take that screw off", "fk4rIZnVuyA-00016-00009876-00009936": "ah", "fk4rIZnVuyA-00017-00011202-00011892": "There you go. All right, so we're gonna take off this cover right here again with a flat head.", "fk4rIZnVuyA-00018-00012648-00013086": "There we go so you guys can see right here, just like a little bit of a", "fk4rIZnVuyA-00019-00013086-00013740": "indentation. You put your Flathead in there. All right, screws, take that out.", "fk4rIZnVuyA-00020-00014700-00014976": "All right now we're going to go ahead and remove the door panel.", "fk4rIZnVuyA-00021-00015041-00015600": "So going on one end whatever you guys can get leverage on. See if I can get leverage down here.", "fk4rIZnVuyA-00022-00016566-00017058": "You can just let that dangle like that. Then right here, we're going to take this off too", "fk4rIZnVuyA-00023-00017406-00017640": "and this one you can just let dangle like that too.", "fk4rIZnVuyA-00024-00017640-00017958": "Okay now I'm gonna go ahead and focus on this area", "fk4rIZnVuyA-00025-00018762-00019080": "All right so we got these 10 millimeter bolts right here. Just three of them,", "fk4rIZnVuyA-00026-00019080-00019524": "and then this plug. So don't unplug it. First go ahead and take off the bolts first", "fk4rIZnVuyA-00027-00020538-00020928": "Bolts are off. Go ahead and use your other hand. Just support it,", "fk4rIZnVuyA-00028-00020928-00021456": "just in case this thing falls down you don't damage anything else on the other side. So", "fk4rIZnVuyA-00029-00021456-00021960": "once it's released, go ahead and hold on to this and then go to the base and wiggle it out", "fk4rIZnVuyA-00030-00022026-00022656": "just like that. All right guys, so if you guys need this mirror for your vehicle, the link is", "fk4rIZnVuyA-00031-00022656-00023142": "down below. It's at ReveMoto.com, your pre-painted auto body parts source. So it's already painted", "fk4rIZnVuyA-00032-00023142-00023538": "and ready to ship to you. Just got to install it. So let's go ahead and install it now.", "fk4rIZnVuyA-00033-00023622-00024540": "All right, to install go ahead and take the mirror right here and slide it back here. Slide the", "fk4rIZnVuyA-00034-00024606-00025188": "cables in and then line it up line the holes up with those uh bolts", "fk4rIZnVuyA-00035-00025656-00026058": "just like that and then put this", "fk4rIZnVuyA-00036-00026262-00026627": "and there you go keep on holding it so in case it falls down.", "fk4rIZnVuyA-00037-00026814-00027474": "go ahead and get those screws right there, or nuts, put them in place.", "fk4rIZnVuyA-00038-00027738-00028326": "Try not to use an impact gun because you might over tighten it and break the studs. So basically,", "fk4rIZnVuyA-00039-00028326-00029052": "just use a, uh, a ratchet set and when you feel the grip. Just a little bit of a turn,", "fk4rIZnVuyA-00040-00029189-00029604": "a little bit of a turn, a little bit of a tur,n there you go.", "fk4rIZnVuyA-00041-00029766-00030048": "All right so when I put this cover back in place", "fk4rIZnVuyA-00042-00031722-00032112": "put the door panel in place. So lift it", "fk4rIZnVuyA-00043-00032639-00033258": "and what I'm doing is I'm pushing the... I lift it above that ledge a little bit higher so I can push", "fk4rIZnVuyA-00044-00033258-00033942": "the door panel back a little bit more. There you go, and it should just go down in place.", "fk4rIZnVuyA-00045-00034056-00034368": "Then, once you tap it, if you know that you got it", "fk4rIZnVuyA-00046-00034368-00034774": "in place because when you tap it it should be easily clipping [in]", "fk4rIZnVuyA-00047-00035214-00035616": "just like that. All right so now I'm going to put the screws back in place.", "fk4rIZnVuyA-00048-00036864-00037416": "This cover, so slide it in first, and then press down.", "fk4rIZnVuyA-00049-00037662-00037764": "The one over here", "fk4rIZnVuyA-00050-00039570-00039852": "and push it down there you go.", "fk4rIZnVuyA-00051-00039926-00040986": "All right guys, so that's how you install a 2016 Acura TLX passenger side view", "fk4rIZnVuyA-00052-00040986-00041382": "mirror. It also works the same side on the driver's side. Thank you guys for watching!"}}, {"audio_id": "fk8chapHBNy", "text": {"fk8chapHBNy-00000-00002992-00003871": "Oh, the words have a ring, it's so obvious", "fk8chapHBNy-00001-00003871-00004455": "Don't have to explain anything, \"The Back of the Bus\"", "fk8chapHBNy-00002-00004688-00005372": "Would that our fight be something like yours", "fk8chapHBNy-00003-00005504-00006196": "We'd all get up right and walk out the door", "fk8chapHBNy-00004-00006360-00006988": "On screaming billboards you pay to disgrace", "fk8chapHBNy-00005-00007136-00007859": "And then to accuse us, what a terrible mistake", "fk8chapHBNy-00006-00007928-00008528": "We have pride in our families so we protect our eyes", "fk8chapHBNy-00007-00008632-00009300": "While Man's true nature you wish to disguise", "fk8chapHBNy-00008-00009448-00010008": "When will you see how much power you have?", "fk8chapHBNy-00009-00010036-00010688": "You defame the small people then the world shoots you back", "fk8chapHBNy-00010-00010740-00011283": "You rightfully cry, \"They accuse wrongfully!\"", "fk8chapHBNy-00011-00011384-00011972": "But you still deny that we should be free", "fk8chapHBNy-00012-00012152-00012800": "Oh, the words have a ring, a forgone conclusion", "fk8chapHBNy-00013-00013028-00013608": "Don't have to explain anything, \"Occupation\"", "fk8chapHBNy-00014-00013960-00014540": "When terrorists strike, they call it a clash", "fk8chapHBNy-00015-00014591-00015319": "But when our soldiers must fight there's a huge backlash", "fk8chapHBNy-00016-00015544-00016128": "So they walk on the back of the bus and do whatever they wish", "fk8chapHBNy-00017-00016297-00016934": "Then Israel's accused of inciting violence", "fk8chapHBNy-00018-00017120-00017637": "It's measure for measure, isn't it obvious?", "fk8chapHBNy-00019-00017772-00018456": "We've come full circle at the back of the bus", "fk8chapHBNy-00020-00018632-00019156": "When will you see how much power you have?", "fk8chapHBNy-00021-00019188-00019830": "You defame the small people then the world shoots you back", "fk8chapHBNy-00022-00019876-00020460": "You rightfully cry, \"They accuse wrongfully!\"", "fk8chapHBNy-00023-00020544-00021172": "But you still deny that we should be free", "fk8chapHBNy-00024-00024688-00025292": "It's an old trick you think from which we can't escape", "fk8chapHBNy-00025-00025476-00026120": "When we criticize, you accuse us of hate", "fk8chapHBNy-00026-00026180-00026808": "When we believe what is right then we stand up for what's true", "fk8chapHBNy-00027-00026983-00027636": "And we won't be selfish, we'll let you try it too!", "fk8chapHBNy-00028-00027788-00028360": "When will you see how much power you have?", "fk8chapHBNy-00029-00028361-00029025": "You defame the small people then the world shoots you back", "fk8chapHBNy-00030-00029048-00029624": "You rightfully cry, \"They accuse wrongfully!\"", "fk8chapHBNy-00031-00029727-00030420": "Maybe you'll try to let us be free"}}, {"audio_id": "fkme2pw0ZLA", "text": {"fkme2pw0ZLA-00000-00000003-00000755": "How do you counter a reactionary international by developing a progressive international? Now there are steps to that.", "fkme2pw0ZLA-00001-00000808-00001008": "They don't get much publicity", "fkme2pw0ZLA-00002-00001021-00001174": "but", "fkme2pw0ZLA-00003-00001174-00001536": "I think it's this coming December. There will be a", "fkme2pw0ZLA-00004-00001602-00001991": "formal announcement of what has been in process for some time.", "fkme2pw0ZLA-00005-00002230-00002359": "Yanis Varoufakis", "fkme2pw0ZLA-00006-00002359-00002645": "the founder and leading figure in", "fkme2pw0ZLA-00007-00002709-00002909": "DiEM25, the", "fkme2pw0ZLA-00008-00002983-00003091": "progressive", "fkme2pw0ZLA-00009-00003091-00003821": "movement in Europe, very important of our focus and Bernie Sanders that came out with the", "fkme2pw0ZLA-00010-00003910-00004137": "declaration calling for a progressive", "fkme2pw0ZLA-00011-00004228-00004428": "international to", "fkme2pw0ZLA-00012-00004441-00005153": "come back, and we hope to overcome the reactionary international based in the White House.", "fkme2pw0ZLA-00013-00005221-00005894": "Now if you look at the level of states, this looks like an extremely unequal  competition", "fkme2pw0ZLA-00014-00005964-00006197": "But states are not the only things that exist.", "fkme2pw0ZLA-00015-00006282-00006482": "If you look at the level of people", "fkme2pw0ZLA-00016-00006526-00006715": "it's not impossible.", "fkme2pw0ZLA-00017-00006715-00007262": "It's possible to construct a progressive international based on people", "fkme2pw0ZLA-00018-00007351-00007468": "ranging", "fkme2pw0ZLA-00019-00007468-00007597": "from the", "fkme2pw0ZLA-00020-00007597-00007704": "organized", "fkme2pw0ZLA-00021-00007704-00008399": "political groups that have been proliferating that have gotten a huge shot in the arm from the", "fkme2pw0ZLA-00022-00008440-00008640": "Sanders campaign,", "fkme2pw0ZLA-00023-00008656-00008856": "ranging from them to", "fkme2pw0ZLA-00024-00008872-00009072": "self-help mutual aid, self-help", "fkme2pw0ZLA-00025-00009154-00009626": "organizations that are arising in communities all over the world in the", "fkme2pw0ZLA-00026-00009693-00009962": "most impoverished areas of Brazil for example", "fkme2pw0ZLA-00027-00010027-00010239": "and even this astonishing", "fkme2pw0ZLA-00028-00010290-00010949": "fact that I mentioned that the murderers, crime gangs are taking responsibility for", "fkme2pw0ZLA-00029-00010999-00011199": "bringing some form of", "fkme2pw0ZLA-00030-00011415-00011604": "decent", "fkme2pw0ZLA-00031-00011604-00012179": "protection against the pandemic and the \"favelas,\" the miserable slums in Rio", "fkme2pw0ZLA-00032-00012247-00012409": "all of this is", "fkme2pw0ZLA-00033-00012409-00012795": "happening on the popular level if it expands and", "fkme2pw0ZLA-00034-00012838-00013214": "develops, if people don't just give up and despair,", "fkme2pw0ZLA-00035-00013243-00013994": "but work to change the world as they've done in the past under much worse conditions. If they do that", "fkme2pw0ZLA-00036-00014034-00014234": "there's a chance for a progressive", "fkme2pw0ZLA-00037-00014284-00014883": "international and notice, bear in mind that there are also striking cases of", "fkme2pw0ZLA-00038-00014968-00015109": "internationalism,", "fkme2pw0ZLA-00039-00015109-00015585": "progressive internationalism at the state level. So take a look at the European Union,", "fkme2pw0ZLA-00040-00015729-00016037": "the rich countries in Europe", "fkme2pw0ZLA-00041-00016075-00016683": "like Germany have recently given us a lesson in just what the Union means.", "fkme2pw0ZLA-00042-00016789-00016918": "Right?", "fkme2pw0ZLA-00043-00016918-00017573": "Germany's managing pretty well. They probably have the lowest death rate in the world. It's an organized society.", "fkme2pw0ZLA-00044-00017725-00017887": "Right next door", "fkme2pw0ZLA-00045-00017887-00018435": "Northern Italy is suffering, miserably. Is  Germany giving the many aid?", "fkme2pw0ZLA-00046-00018478-00018576": "No.", "fkme2pw0ZLA-00047-00018576-00019142": "In fact, Germany even blocked the effort to develop Eurobonds,", "fkme2pw0ZLA-00048-00019182-00019568": "general the bonds in Europe, which could be used to alleviate", "fkme2pw0ZLA-00049-00019626-00020099": "the suffering in the countries under worse the worst conditions", "fkme2pw0ZLA-00050-00020125-00020513": "But fortunately for Italy it can look across the Atlantic", "fkme2pw0ZLA-00051-00020584-00021056": "for aid from the superpower on the western hemisphere.", "fkme2pw0ZLA-00052-00021139-00021310": "Cuba.", "fkme2pw0ZLA-00053-00021310-00021456": "Cuba is", "fkme2pw0ZLA-00054-00021456-00021656": "once again as before", "fkme2pw0ZLA-00055-00021732-00021868": "exhibiting", "fkme2pw0ZLA-00056-00021868-00022009": "extraordinary", "fkme2pw0ZLA-00057-00022009-00022209": "internationalism sending doctors", "fkme2pw0ZLA-00058-00022270-00022661": "to Italy. Germany won't do it, but Cuba can.", "fkme2pw0ZLA-00059-00022863-00023081": "China is providing materially.", "fkme2pw0ZLA-00060-00023170-00023341": "So these are", "fkme2pw0ZLA-00061-00023341-00023789": "steps towards progressive internationalism at the state level."}}, {"audio_id": "fkLcVu0ZapY", "text": {"fkLcVu0ZapY-00000-00000062-00000375": "A map shows land and water.", "fkLcVu0ZapY-00001-00000375-00000645": "A map usually has a key.", "fkLcVu0ZapY-00002-00000645-00001204": "The key uses symbols to show places on the map.", "fkLcVu0ZapY-00003-00001204-00001545": "This is a map of Washington State.", "fkLcVu0ZapY-00004-00001545-00001918": "You can see the key on the left.", "fkLcVu0ZapY-00005-00001918-00002874": "There are cities, highways, mountains, rivers, and a ocean.", "fkLcVu0ZapY-00006-00002874-00003534": "This part of the key shows the sizes of the population of cities with bigger or smaller", "fkLcVu0ZapY-00007-00003534-00003899": "letters.", "fkLcVu0ZapY-00008-00003899-00004923": "This part of the key shows symbols for highways and other transportation.", "fkLcVu0ZapY-00009-00004923-00006083": "This part of the key shows symbols for streams, rivers, lakes, mountains, and the ocean.", "fkLcVu0ZapY-00010-00006083-00006868": "This part of the key shows distance in miles.", "fkLcVu0ZapY-00011-00006868-00007148": "This is a compass rose.", "fkLcVu0ZapY-00012-00007148-00008148": "It shows the directions, north, south, east, and west, on the map.", "fkLcVu0ZapY-00013-00008148-00008995": "Here you can see many cities in Washington State and their sizes.", "fkLcVu0ZapY-00014-00008995-00009486": "Here you can see the three mountain ranges in Washington State.", "fkLcVu0ZapY-00015-00009486-00009882": "The Olympic Mountains are by the Pacific Ocean.", "fkLcVu0ZapY-00016-00009882-00010182": "The Cascades are in the middle.", "fkLcVu0ZapY-00017-00010182-00010943": "The Wenatchee Mountains are east of the Cascades and are smaller.", "fkLcVu0ZapY-00018-00010943-00011769": "The Columbia River is a large river between Washington and Oregon.", "fkLcVu0ZapY-00019-00011769-00012841": "Interstate 5, or I-5, is an important highway in Washington State.", "fkLcVu0ZapY-00020-00012841-00013415": "The Pacific Ocean is to the west of Washington State."}}, {"audio_id": "fkSh0pij7YM", "text": {"fkSh0pij7YM-00000-00000016-00000509": "Okay, so right here I have TagTime Web, which is a stochastic time tracking website that", "fkSh0pij7YM-00001-00000509-00000560": "I made.", "fkSh0pij7YM-00002-00000560-00000716": "I'll show you how it works.", "fkSh0pij7YM-00003-00000716-00000901": "So first, I'm going to sign up.", "fkSh0pij7YM-00004-00000901-00001154": "Okay, so this is what you get when you sign up.", "fkSh0pij7YM-00005-00001154-00001334": "I'm going to hit \"Get started'.", "fkSh0pij7YM-00006-00001334-00001552": "And okay, so I got my first ping.", "fkSh0pij7YM-00007-00001552-00001988": "Okay, so it asks me: okay, it's tag time, what am I doing exactly at this time?", "fkSh0pij7YM-00008-00001988-00002126": "So I can enter it in.", "fkSh0pij7YM-00009-00002126-00002377": "So let's say, \"recording\", \"video\".", "fkSh0pij7YM-00010-00002377-00002543": "They're just tags.", "fkSh0pij7YM-00011-00002543-00002764": "Notice how each one of these has it's own color.", "fkSh0pij7YM-00012-00002764-00003130": "If I add in some more, they all have a unique color.", "fkSh0pij7YM-00013-00003130-00003521": "And then I just can hit enter to complete the tags (or hit the little button).", "fkSh0pij7YM-00014-00003521-00003847": "Now, if I go into \"Pings\", I can see my historical pings.", "fkSh0pij7YM-00015-00003847-00004079": "So, this is the one I that I just entered.", "fkSh0pij7YM-00016-00004079-00004424": "If I go into \"Settings\", there's a few settings I can change.", "fkSh0pij7YM-00017-00004424-00004986": "So I can (and this displays on the homepage too) hit this button and enable notifications,", "fkSh0pij7YM-00018-00004986-00005310": "so I get a notification whenever there's a ping.", "fkSh0pij7YM-00019-00005310-00005598": "I can make it so it plays audio whenever there's a ping.", "fkSh0pij7YM-00020-00005598-00005940": "[Music]", "fkSh0pij7YM-00021-00005940-00006068": "It doesn't matter which one you choose.", "fkSh0pij7YM-00022-00006068-00006602": "That way you know when there's a ping, in addition to the notifications of course.", "fkSh0pij7YM-00023-00006602-00006808": "Here you can change how often pings occur.", "fkSh0pij7YM-00024-00006808-00007276": "So if I change this to something like 2 minutes, and hit \"Update\", then now we'll get pings", "fkSh0pij7YM-00025-00007276-00007590": "on average, 2 minutes apart.", "fkSh0pij7YM-00026-00007590-00008016": "Here I can change the default pings when I'm AFK: away from keyboard.", "fkSh0pij7YM-00027-00008016-00008290": "You can import or export from a TagTime log by clicking that.", "fkSh0pij7YM-00028-00008290-00008536": "It will just download my TagTime log.", "fkSh0pij7YM-00029-00008536-00008816": "And, you can even change it to dark mode.", "fkSh0pij7YM-00030-00008816-00009132": "So let's go back to the homepage and wait for the next ping.", "fkSh0pij7YM-00031-00009132-00009367": "Okay, so now we've got a new ping.", "fkSh0pij7YM-00032-00009367-00009604": "So, if I hit \"More info\", it just shows you more info.", "fkSh0pij7YM-00033-00009604-00010268": "Here's a neat trick: if you hit the double/single quote, then it will just repeat all the previous tags.", "fkSh0pij7YM-00034-00010268-00010448": "And notice how it says \"afk\" here?", "fkSh0pij7YM-00035-00010448-00010748": "That's because I didn't answer the previous ping, so it just assumed I was away from the", "fkSh0pij7YM-00036-00010749-00010849": "keyboard.", "fkSh0pij7YM-00037-00010849-00011178": "You also can't have duplicate tags: like if I type in \"video\" again it just disappears", "fkSh0pij7YM-00038-00011178-00011482": "because it doesn't make sense to have duplicate tags.", "fkSh0pij7YM-00039-00011482-00011688": "Yeah, that's it.", "fkSh0pij7YM-00040-00011688-00012478": "There are a few more features, but that's the basics of using TagTime Web."}}, {"audio_id": "fkTxf9z0XDU", "text": {"fkTxf9z0XDU-00000-00000003-00000348": "Those wanting to stop the UK's disastrous crash out of the EU should", "fkTxf9z0XDU-00001-00000348-00000791": "feel greatly encouraged by Dr von der Leyen's comments about Brexit. I was", "fkTxf9z0XDU-00002-00000791-00001134": "delighted to hear you call yourself a Remainer to our group and to say that", "fkTxf9z0XDU-00003-00001134-00001470": "you would be willing to give us the extra time we may need to resolve this", "fkTxf9z0XDU-00004-00001470-00001896": "deeply damaging episode in our country's history. But on a range of issues, from", "fkTxf9z0XDU-00005-00001896-00002303": "tax and trade to climate and protecting life in our countryside, there is a gulf", "fkTxf9z0XDU-00006-00002303-00002801": "between your views and the Green agenda for change. Most importantly I cannot", "fkTxf9z0XDU-00007-00002801-00003143": "vote for you, because the appointment's process that led us here, is a step away", "fkTxf9z0XDU-00008-00003143-00003732": "from closer engagement with citizens and from democracy. The backroom deal done in", "fkTxf9z0XDU-00009-00003732-00004071": "the Council explicitly reassured the far-right in the countries of Central", "fkTxf9z0XDU-00010-00004071-00004446": "Europe, where the rule of law is under threat and democratic standards are at", "fkTxf9z0XDU-00011-00004446-00004845": "risk. It's so disappointing that the election of the Commission president", "fkTxf9z0XDU-00012-00004845-00005194": "will depend on the votes of the far-right rather than those of a strong", "fkTxf9z0XDU-00013-00005194-00005546": "pro-European majority that could have been achieved by offering the radical", "fkTxf9z0XDU-00014-00005546-00005792": "change that Green voters demand."}}, {"audio_id": "fl2_2iy4Flg", "text": {"fl2_2iy4Flg-00000-00000000-00000315": "Jamong, let's go get a massage.", "fl2_2iy4Flg-00001-00000508-00000881": "It's time for Jamong's massage.", "fl2_2iy4Flg-00002-00000943-00001500": "Apple... Apple doesn't understand the mood.", "fl2_2iy4Flg-00003-00001593-00001686": "Let's go.", "fl2_2iy4Flg-00004-00001972-00002673": "Jamong, Jamong, did you have a guest? Here comes a massage.", "fl2_2iy4Flg-00005-00002673-00002891": "Oh, it's so cool.", "fl2_2iy4Flg-00006-00003414-00003873": "Mango is unfamiliar? Mango's mom's room is unfamiliar? Come quickly.", "fl2_2iy4Flg-00007-00003932-00004335": "Blue is here? Oh, you look like twins.", "fl2_2iy4Flg-00008-00004641-00004909": "Please wait a little bit.", "fl2_2iy4Flg-00009-00004932-00005252": "Customer, please wait a little bit. Jamong will go first.", "fl2_2iy4Flg-00010-00005864-00006229": "What's this place for?", "fl2_2iy4Flg-00011-00006946-00007664": "Maybe it's the same as when I was raising a baby.", "fl2_2iy4Flg-00012-00007807-00008418": "Dogs are the same as when they raise babies.", "fl2_2iy4Flg-00013-00010126-00010671": "Urgent waiting guests.", "fl2_2iy4Flg-00014-00013553-00015725": "Blue, don't you keep the order? It's not your turn."}}, {"audio_id": "flBkMUaQt0g", "text": {"flBkMUaQt0g-00000-00000000-00000200": "How to create calculator"}}, {"audio_id": "fmPBE8KOCaM", "text": {"fmPBE8KOCaM-00000-00001637-00002143": "welcome to my channel and I am adriano de carlo and today we will talk about mantras", "fmPBE8KOCaM-00001-00002232-00002711": "The first thing we are going to do is determine the etymological origin of the term.", "fmPBE8KOCaM-00002-00002761-00003436": "So, we can establish that mantra emanates from Sanskrit and is the result of the sum of two elements:", "fmPBE8KOCaM-00003-00003532-00004128": "the word mans, which can be defined as \"mind\", and tra, which is synonymous with \"liberation\".", "fmPBE8KOCaM-00004-00004195-00004469": "Mantra is a term that can be translated as “thought”.", "fmPBE8KOCaM-00005-00004535-00004874": "In religions such as Buddhism and Hinduism", "fmPBE8KOCaM-00006-00004937-00005612": "a mantra is a sacred phrase, word, or syllable that is recited in support of meditation or to invoke divinity.", "fmPBE8KOCaM-00007-00005680-00006382": "It is important to emphasize the fact that, as a general rule, mantras are usually made up of long sentences.", "fmPBE8KOCaM-00008-00006453-00006899": "However, this circumstance is an exception in Hinduism,", "fmPBE8KOCaM-00009-00006922-00007636": "since in this religion it is committed, however, by chains of mantras, litanies and stanzas.", "fmPBE8KOCaM-00010-00007686-00008345": "In addition to all this, it must be determined that mantras are used in the following way to be useful:", "fmPBE8KOCaM-00011-00008345-00009039": "• They are pronounced by individuals both aloud and internally, according to the circumstances of each moment.", "fmPBE8KOCaM-00012-00009124-00009573": "They are repeated constantly and in a rhythmic way.", "fmPBE8KOCaM-00013-00009573-00010638": "• As is the case in the Christian religion, in some cases it is usually used a series of elements that contribute to following the chain of mantras,", "fmPBE8KOCaM-00014-00010682-00010992": "not to get lost and to count them.", "fmPBE8KOCaM-00015-00011023-00011600": "In that they are known as rosaries and in other religions they are called mapalas.", "fmPBE8KOCaM-00016-00011632-00012041": "• Thanks to mantras, what is achieved is that the person who recites them", "fmPBE8KOCaM-00017-00012081-00012839": "You can relax, focus on a certain task and also stop the wanderings in his mind.", "fmPBE8KOCaM-00018-00012839-00013301": "All this without forgetting that they will also help that individual to eliminate from his head", "fmPBE8KOCaM-00019-00013363-00013956": "all kinds of impure thoughts and that prevent him from purifying everything that he has around him.", "fmPBE8KOCaM-00020-00014000-00014094": "The mantra", "fmPBE8KOCaM-00021-00014144-00014651": "acts as a tool that helps free the mind from the constant flow of thoughts.", "fmPBE8KOCaM-00022-00014791-00015286": "Thanks to the repetition of the mantra, the person enters a state of deep concentration.", "fmPBE8KOCaM-00023-00015335-00015556": "Meditation, with the help of the mantra,", "fmPBE8KOCaM-00024-00015604-00016321": "allows the subject to focus his attention on his own consciousness, on an external thought or object.", "fmPBE8KOCaM-00025-00016361-00016751": "Although mantras do not have an exact or precise meaning,", "fmPBE8KOCaM-00026-00016751-00016912": "each sound is said to correspond", "fmPBE8KOCaM-00027-00016938-00017419": "to an aspect of enlightenment and allows the mind to be associated with one of these aspects.", "fmPBE8KOCaM-00028-00017445-00017810": "The most popular mantra in Buddhism is “om mani padme hum,”", "fmPBE8KOCaM-00029-00017837-00018016": "which corresponds to compassion.", "fmPBE8KOCaM-00030-00018024-00018348": "Its most frequent translation is “The jewel in the lotus.”", "fmPBE8KOCaM-00031-00018348-00019064": "Buddhists hold that the six syllables of this mantra are linked to bliss or meditation", "fmPBE8KOCaM-00032-00019064-00019784": "(om), patience (ma), discipline (ni), wisdom (pad), generosity (me), and diligence (hum ).", "fmPBE8KOCaM-00033-00019824-00020241": "Buddhist traditions indicate that the mantra will take effect", "fmPBE8KOCaM-00034-00020241-00020699": "only if its recitation is authorized or supervised by a lama or guru", "fmPBE8KOCaM-00035-00020735-00020920": "For some leaders like the Dalai Lama,", "fmPBE8KOCaM-00036-00020951-00021312": "the mantra “om mani padme hum” is always useful, but the one who recites", "fmPBE8KOCaM-00037-00021356-00021587": "it must think about its meaning.", "fmPBE8KOCaM-00038-00021618-00022058": "Among the Hindus, one of the best known mantras is “om namah shivaia”", "fmPBE8KOCaM-00039-00022123-00022423": "which is usually translated as “Obeisances to Shivá”", "fmPBE8KOCaM-00040-00022583-00023104": "In this case we share with you all a powerful Tibetan sacred mantra of god Ganesh", "fmPBE8KOCaM-00041-00023210-00023337": "* This mantra", "fmPBE8KOCaM-00042-00023390-00023488": "has a powerful energy", "fmPBE8KOCaM-00043-00023519-00023870": "and can be used before starting a new profession, a course,", "fmPBE8KOCaM-00044-00023924-00024681": "a trip, a new contract, a change of residence, so that all obstacles that could prevent it from functioning are broken.", "fmPBE8KOCaM-00045-00024721-00024953": "OM is the primary invocation", "fmPBE8KOCaM-00046-00025000-00025370": "establishing contact between the practitioner and the divinity.", "fmPBE8KOCaM-00047-00025388-00025558": "GAM is a Sanskrit verb,", "fmPBE8KOCaM-00048-00025580-00026021": "which means to go, move, move away, come, get closer, join;", "fmPBE8KOCaM-00049-00026071-00026348": "In Ganesha Maha Mantra means the sacred syllable", "fmPBE8KOCaM-00050-00026379-00026544": "representing Lord Ganesha himself.", "fmPBE8KOCaM-00051-00026566-00026663": "GANAPATI", "fmPBE8KOCaM-00052-00026685-00026873": "is one of the names Ganesha receives,", "fmPBE8KOCaM-00053-00026908-00027154": "the word can be divided into two:", "fmPBE8KOCaM-00054-00027172-00027650": "GHANA + PATI and thus, GHANA means PRAISE  and PATI means LORD.", "fmPBE8KOCaM-00055-00027703-00028153": "NAMAS is worship. In the mantra it appears as NAMAH.", "fmPBE8KOCaM-00056-00028202-00028501": "This is a powerful Mantra for removing obstacles.", "fmPBE8KOCaM-00057-00028545-00028819": "Chanting this mantra helps", "fmPBE8KOCaM-00058-00028841-00029023": "spiritual evolution by removing", "fmPBE8KOCaM-00059-00029054-00029330": "all obstacles and opening the way to prosperity.", "fmPBE8KOCaM-00060-00029459-00029661": "Lord Ganesha, Ganesh or Ganapati", "fmPBE8KOCaM-00061-00029696-00030120": "is one of the most revered  Hindu gods of all time,", "fmPBE8KOCaM-00062-00030152-00030362": "he is a divinity very much loved by the Indians.", "fmPBE8KOCaM-00063-00030438-00030949": "Ganesha loves human beings and those who turn to him with faith and determination,", "fmPBE8KOCaM-00064-00030981-00031461": "he responds by destroying the obstacles that impede the material and spiritual development", "fmPBE8KOCaM-00065-00031521-00031639": "of the individual,", "fmPBE8KOCaM-00066-00031714-00032078": "thus providing balance and conditions for expansion and growth.", "fmPBE8KOCaM-00067-00032109-00032380": "Ganesha is associated with children (purity)", "fmPBE8KOCaM-00068-00032460-00033091": "communication, intelligence, intellectual strength, manliness, and ethical and moral duty.", "fmPBE8KOCaM-00069-00033149-00033499": "Ganesha guides the path of the human being, illuminating and removing obstacles", "fmPBE8KOCaM-00070-00033575-00033698": "and much more", "fmPBE8KOCaM-00071-00033729-00034457": "Ganesha is the first son of Shiva and Parvati, and considered one of the most important and beloved gods of this rich culture.", "fmPBE8KOCaM-00072-00034590-00035256": "So without further talking I share this beautiful mantra below and I hope it can be of help in these difficult times ....", "fmPBE8KOCaM-00073-00035320-00035584": "if you like the video, share it, comment and subscribe to the channel", "fmPBE8KOCaM-00074-00035615-00035857": "to allow you to continue growing", "fmPBE8KOCaM-00075-00035857-00036058": "helping more people", "fmPBE8KOCaM-00076-00036090-00036299": "in the process of spiritual elevation", "fmPBE8KOCaM-00077-00036339-00036532": "or simply to be able to fully live", "fmPBE8KOCaM-00078-00036599-00036850": "all the benefits of a happy life", "fmPBE8KOCaM-00079-00036895-00037048": "NAMASTE"}}, {"audio_id": "fnfbQPjwdqQ", "text": {"fnfbQPjwdqQ-00000-00001096-00002002": "In there this little one-page is something of a guy to it", "fnfbQPjwdqQ-00001-00003219-00004410": "that's that's all I have right now I'll be before we get to the point where", "fnfbQPjwdqQ-00002-00004410-00005017": "we're rushing to the airport I thought it'd be important now to to talk about", "fnfbQPjwdqQ-00003-00005017-00005560": "scheduling the next meeting so we get some sense of people's calendars while", "fnfbQPjwdqQ-00004-00005560-00006880": "everyone is here I think I've heard from several that June is is out about July", "fnfbQPjwdqQ-00005-00006880-00007713": "is that out of the question for anyone", "fnfbQPjwdqQ-00006-00009180-00009410": "all", "fnfbQPjwdqQ-00007-00010283-00011540": "okay Chris ocher late July okay so Mike do you want to have someone from your", "fnfbQPjwdqQ-00008-00011540-00012194": "office try to schedule a specific times well you know if we're able to do it now", "fnfbQPjwdqQ-00009-00012194-00013263": "okay we're probably three days I think so", "fnfbQPjwdqQ-00010-00015088-00016141": "well yeah but also we have a lot of stuff on the disks that I think will be", "fnfbQPjwdqQ-00011-00016141-00016599": "really generate some questions", "fnfbQPjwdqQ-00012-00017640-00018032": "yeah is that the look is it the July meeting when we will have people coming", "fnfbQPjwdqQ-00013-00018032-00018714": "in and talking to us yeah that's that's the plan and you know I think we we do", "fnfbQPjwdqQ-00014-00018714-00019289": "have a lot of data available it's just we haven't had a chance to absorb it all", "fnfbQPjwdqQ-00015-00019289-00020217": "and I think that we certainly try to have have something by whoa we'll have", "fnfbQPjwdqQ-00016-00020217-00020501": "something by then", "fnfbQPjwdqQ-00017-00021725-00023269": "the third week better than the fourth week okay third week fourth is better", "fnfbQPjwdqQ-00018-00023599-00024835": "26th last week is not as good as the third week", "fnfbQPjwdqQ-00019-00025767-00026282": "Vernon if we had it for the end of the third week would that help", "fnfbQPjwdqQ-00020-00026833-00027782": "we had the 21st 22nd and 23rd people have to fly in on the 20th some of us", "fnfbQPjwdqQ-00021-00028995-00030279": "it's important that you be here so so we drop down to the 26th what what are the", "fnfbQPjwdqQ-00022-00030279-00031001": "issues Holger for you okay we'll be okay", "fnfbQPjwdqQ-00023-00031045-00031379": "and Paul", "fnfbQPjwdqQ-00024-00032438-00033636": "alright ok but let's let's schedule it for the 26th 27th and 28th and now the I", "fnfbQPjwdqQ-00025-00033636-00034484": "guess the question is if you have the testimony on the 26th and then meet the", "fnfbQPjwdqQ-00026-00034484-00035312": "have a regular meeting the next two days yes okay okay", "fnfbQPjwdqQ-00027-00037128-00038392": "okay so moving on we were going to discuss today a point that Byrne brought", "fnfbQPjwdqQ-00028-00038392-00039076": "up about you know what is acceptable risk and how are we going to deal with", "fnfbQPjwdqQ-00029-00039076-00039664": "it specifically in terms of endpoints but before we do that andreas was going", "fnfbQPjwdqQ-00030-00039664-00040573": "to make a presentation that hopefully will enlighten us in this discussion do", "fnfbQPjwdqQ-00031-00040573-00042159": "you have anything - oh do you", "fnfbQPjwdqQ-00032-00044428-00044934": "just to let you all know this is being recorded so when you speak please turn", "fnfbQPjwdqQ-00033-00044934-00045602": "on your microphone and speak into the microphone thank you", "fnfbQPjwdqQ-00034-00046963-00048521": "we'll work the slides or I can do it the red button is the pointer arrow what I", "fnfbQPjwdqQ-00035-00048521-00049559": "speak into this microphone so I thought I start off by talking a little about", "fnfbQPjwdqQ-00036-00049559-00050204": "the general background of our work some mixture data and then our little attempt", "fnfbQPjwdqQ-00037-00050204-00050765": "at cumulative risk assessment which as you will see will probably will most", "fnfbQPjwdqQ-00038-00050765-00051354": "definitely show up the data gaps and problems which we have but may be also", "fnfbQPjwdqQ-00039-00051354-00052405": "useful for illustrating a way forward so this is just the reminder our work is", "fnfbQPjwdqQ-00040-00052405-00053230": "motivated by investigating the role of chemical exposures in what is called the", "fnfbQPjwdqQ-00041-00053230-00053744": "testicular distance syndrome this is a concept developed by sharp and ska", "fnfbQPjwdqQ-00042-00053744-00054476": "Quebec there is at the moment in Europe and I gather here in the US as well", "fnfbQPjwdqQ-00043-00054476-00055285": "great concern about disease trends for non descending testes cryptorchidism", "fnfbQPjwdqQ-00044-00055285-00055994": "the trend is going up in Europe as well for semen quality in parts of Europe the", "fnfbQPjwdqQ-00045-00055994-00056864": "semen quality and young men approaches crisis proportions that I have according", "fnfbQPjwdqQ-00046-00056864-00057314": "to a study which was carried out as part of an EU project with which I", "fnfbQPjwdqQ-00047-00057314-00058129": "coordinated it was found that 20% of young Germans 18 to 19 year olds have", "fnfbQPjwdqQ-00048-00058129-00059122": "semen semen numbers below 20 million per milliliter which is the official limit", "fnfbQPjwdqQ-00049-00059122-00059876": "by whu-oh where you can require assisted fertilization so this is not good and", "fnfbQPjwdqQ-00050-00059876-00060305": "later in life it's and get better so there's great concern", "fnfbQPjwdqQ-00051-00060305-00060929": "about that then we have hypospadias this is a malformation of the penis as you", "fnfbQPjwdqQ-00052-00060929-00061557": "know where the urethral opening is on the underside of the glans penis and not", "fnfbQPjwdqQ-00053-00061557-00062057": "at the top as it should be and finally test his cancer that's also", "fnfbQPjwdqQ-00054-00062057-00062867": "going up in Europe in parts or leveling off at a fairly high level and ska", "fnfbQPjwdqQ-00055-00062867-00063710": "Quebec and Sharpe have proposed that all these disorders are indicative of a", "fnfbQPjwdqQ-00056-00063719-00064311": "malfunctioning of androgen programming in fetal life so they all go back to a", "fnfbQPjwdqQ-00057-00064311-00065010": "to a problem during development related to androgen insufficiency let me clarify", "fnfbQPjwdqQ-00058-00065010-00065847": "they say that not all cases of say hypospadias have to do with what they", "fnfbQPjwdqQ-00059-00065847-00066261": "term the testicular disjoined syndrome not all of them there are", "fnfbQPjwdqQ-00060-00066261-00066747": "in particular with hypospadias some well-defined genetic disorders which", "fnfbQPjwdqQ-00061-00066747-00067476": "lead to these problems that's not necessarily to do with the TTS but the", "fnfbQPjwdqQ-00062-00067476-00068349": "concept I propose has been very fruitful in directing research though it is", "fnfbQPjwdqQ-00063-00068349-00068949": "really that is what's the summary of a lot of research both here in the US and", "fnfbQPjwdqQ-00064-00068949-00069705": "in Europe is that the action of fetal androgens makes a man a man so if there", "fnfbQPjwdqQ-00065-00069705-00070323": "are problems with fetal interaction the affected individuals show signs of", "fnfbQPjwdqQ-00066-00070323-00071276": "feminization so there is one to be known now that certain chemicals can disrupt", "fnfbQPjwdqQ-00067-00071276-00071754": "hormone action in fetal life by either blocking the receptor the androgen", "fnfbQPjwdqQ-00068-00071754-00072441": "receptor or by suppressing sex hormone synthesis and this leads to the", "fnfbQPjwdqQ-00069-00072441-00073058": "masculinization and we have in the rat a very good model that is able to", "fnfbQPjwdqQ-00070-00073058-00073587": "recapitulate balls three of the disorders that make up the", "fnfbQPjwdqQ-00071-00073587-00074481": "testicular just Genesis syndrome only it is impossible to study testicular cancer", "fnfbQPjwdqQ-00072-00074481-00075141": "in the rat which has to do with when the spermatocytes mature in in a rat's life", "fnfbQPjwdqQ-00073-00075141-00075714": "but all the other elements of the testicular DeGeneres's syndrome can be", "fnfbQPjwdqQ-00074-00075714-00076440": "recapitulated in the rat and they the male offspring of females treated with", "fnfbQPjwdqQ-00075-00076440-00077109": "certain chemicals then show signs of deep masculinization the problem is or", "fnfbQPjwdqQ-00076-00077109-00077657": "the question definitely this model has relevance to human because the", "fnfbQPjwdqQ-00077-00077657-00078489": "programming in fetal life is basically the same in in these mammals and in", "fnfbQPjwdqQ-00078-00078489-00079269": "humans the question that is not resolved is do chemicals really play a role in", "fnfbQPjwdqQ-00079-00079269-00080348": "these adverse disease trends in the urine now here a little jump to how", "fnfbQPjwdqQ-00080-00080348-00080940": "toxicology would assess chemicals normally here's the example of", "fnfbQPjwdqQ-00081-00080940-00081722": "vinclozolin that's a pesticide often found in red wine it is a fungicide so", "fnfbQPjwdqQ-00082-00081722-00082392": "people who love red wines from Italy have you can show the traces of that", "fnfbQPjwdqQ-00083-00082392-00082955": "pesticide in their in their urine the breakdown products you will find and", "fnfbQPjwdqQ-00084-00082955-00083724": "when close line is one well studied chemical in this rat model and typically", "fnfbQPjwdqQ-00085-00083724-00084207": "de masculinizing effects are seen at doses around five milligram per kilo and", "fnfbQPjwdqQ-00086-00084207-00084870": "body white per day that is the dose to the pregnant female the human exposures", "fnfbQPjwdqQ-00087-00084870-00085632": "are in Europe at least in this range which you can if you divide the human", "fnfbQPjwdqQ-00088-00085632-00086136": "exposure by the dose that leads to first effects in the rat or just not effect", "fnfbQPjwdqQ-00089-00086136-00086537": "you can see there's a margin of safety as it is called", "fnfbQPjwdqQ-00090-00086537-00087260": "old off between 200 to 1000 and at this point most regulatory toxicologists", "fnfbQPjwdqQ-00091-00087260-00088028": "would say fine case closed no case to answer move over but there is the issues", "fnfbQPjwdqQ-00092-00088028-00088538": "of toxic cocktails as it is called all mixtures or exposure to combined", "fnfbQPjwdqQ-00093-00088538-00089045": "chemicals or many chemicals simultaneously and the question that has", "fnfbQPjwdqQ-00094-00089045-00089627": "inspired a lot of our work during last 10 years is can chemicals that are safe", "fnfbQPjwdqQ-00095-00089627-00090334": "on their own if you like gang up in our bodies to produce effects that cannot be", "fnfbQPjwdqQ-00096-00090334-00090899": "anticipated by studying those chemicals in isolation and secondly are these", "fnfbQPjwdqQ-00097-00090899-00091514": "effects predictable if we know the potency of the individual players and", "fnfbQPjwdqQ-00098-00091514-00092102": "here's a quick summary I'll take you through in stages through some key", "fnfbQPjwdqQ-00099-00092102-00092590": "findings relevant to our work here first of all there's this landmark paper by", "fnfbQPjwdqQ-00100-00092590-00093289": "grace group how to sell a tile it came out in 2008 which shows that solids", "fnfbQPjwdqQ-00101-00093289-00093972": "combination of solids act additively in producing mixture effects the end point", "fnfbQPjwdqQ-00102-00093972-00094682": "they'll sorry the end point they looked at force testosterone production so here", "fnfbQPjwdqQ-00103-00094682-00095195": "you see these are these gray lines are individual dose response cuffs the", "fnfbQPjwdqQ-00104-00095195-00095714": "regression models for the farfa lights harvest a little studied so you see here", "fnfbQPjwdqQ-00105-00095714-00096725": "as we escalate the dose the testosterone synthesis goes down in fetal life they", "fnfbQPjwdqQ-00106-00096725-00097631": "prepared a mixture of these 5 solids at a certain mixture ratio and then using", "fnfbQPjwdqQ-00107-00097631-00098105": "those gray curves it is possible to construct what the predicted combined", "fnfbQPjwdqQ-00108-00098105-00098702": "effect of these 5 solids should look like it is for a mixture of specific", "fnfbQPjwdqQ-00109-00098702-00099488": "mixture ratio and then that's a very strong heuristic tool because it you can", "fnfbQPjwdqQ-00110-00099488-00099821": "design the mixture experiment on the basis of this prediction", "fnfbQPjwdqQ-00111-00099821-00100202": "that's what how to silent I'll did and these are the observations and they", "fnfbQPjwdqQ-00112-00100202-00101063": "match fairly well what can be predicted on the basis of the individual dose", "fnfbQPjwdqQ-00113-00101063-00101639": "response curves the conclusion from this was that these five phalates act", "fnfbQPjwdqQ-00114-00101639-00102173": "together in a dose additive fashion to produce suppressions of testosterone", "fnfbQPjwdqQ-00115-00102173-00102923": "synthesis maybe a little word about what those addition is there are two", "fnfbQPjwdqQ-00116-00102923-00103493": "competing models in by which such additive 'ti predictions can be", "fnfbQPjwdqQ-00117-00103493-00104042": "calculated or constructed one is called dose addition it works on the assumption", "fnfbQPjwdqQ-00118-00104042-00104741": "that one equally effective dose of one component in the mixture can be replaced", "fnfbQPjwdqQ-00119-00104741-00105452": "by as the actory effective fraction of another one the concept finds wide use", "fnfbQPjwdqQ-00120-00105452-00106079": "in the application of TOC tcdd equivalence factors for evaluating the", "fnfbQPjwdqQ-00121-00106079-00106646": "auxin mixtures the competing concept would be called independent action or", "fnfbQPjwdqQ-00122-00106646-00107243": "some people call it response addition and this there are other considerations", "fnfbQPjwdqQ-00123-00107243-00107893": "and other approaches going into this put simply this model works on stochastic", "fnfbQPjwdqQ-00124-00107893-00108566": "principles and assumes that each chemical does what it does in a fashion", "fnfbQPjwdqQ-00125-00108566-00108995": "independent from all the others mathematically these two concepts are", "fnfbQPjwdqQ-00126-00108995-00109663": "different but often they produce the same exactly the same prediction for", "fnfbQPjwdqQ-00127-00109663-00110297": "certain mixtures so for example in this case here you could calculate an", "fnfbQPjwdqQ-00128-00110297-00110806": "additive 'ti prediction for independent action and it would sit very closely", "fnfbQPjwdqQ-00129-00110806-00111373": "near the dose addition prediction that under certain circumstances these two", "fnfbQPjwdqQ-00130-00111373-00112186": "predictions about diverge the question then is which of those two competing", "fnfbQPjwdqQ-00131-00112186-00112817": "models can approximate the observed mixture effects best so far as you will", "fnfbQPjwdqQ-00132-00112817-00113171": "see in this area of study the answer is that", "fnfbQPjwdqQ-00133-00113171-00114107": "sedition is fairly useful so that that's the first landmark paper we in together", "fnfbQPjwdqQ-00134-00114107-00114638": "with all our houses group in Copenhagen the Danish Technical University have", "fnfbQPjwdqQ-00135-00114638-00115060": "spent a lot of time studying these chemicals in a sim in a rat", "fnfbQPjwdqQ-00136-00115060-00115595": "developmental toxicity model this slide just shows you briefly how this", "fnfbQPjwdqQ-00137-00115595-00116132": "experiment is designed this here's the lifeline of a female pregnant rat so", "fnfbQPjwdqQ-00138-00116132-00116891": "they get pregnant here dosing begins on gestational day seven and normally", "fnfbQPjwdqQ-00139-00116891-00117436": "throughout the entire pregnancy through birth up until personal natal day", "fnfbQPjwdqQ-00140-00117436-00118094": "sixteen then here is they give birth to offspring typically six males and six", "fnfbQPjwdqQ-00141-00118094-00119053": "females and here's the lifeline of the young male rat very early after birth", "fnfbQPjwdqQ-00142-00119053-00119716": "the anal genital distance is measured that can be done in a non-invasive", "fnfbQPjwdqQ-00143-00119716-00120428": "fashion so these little rats live on then a little later on personated a", "fnfbQPjwdqQ-00144-00120428-00121028": "sixteen samples are taken some are sacrificed and the organ weights are", "fnfbQPjwdqQ-00145-00121028-00121483": "measured off organs that are under the control of androgen action so for", "fnfbQPjwdqQ-00146-00121483-00122133": "example the prostate and various other sex accessory organs and also", "fnfbQPjwdqQ-00147-00122133-00122836": "malformations of the penis are evaluated and then later that's the person natal", "fnfbQPjwdqQ-00148-00122836-00123517": "day 47 malformations of the penis I looked at again so we look but look at", "fnfbQPjwdqQ-00149-00123517-00124309": "things that really recapitulate hypospadias in humans so here's the", "fnfbQPjwdqQ-00150-00124309-00125225": "first result of of a long study which we conducted we looked at this was really", "fnfbQPjwdqQ-00151-00125225-00125780": "the intention of this experiment was not to model environmentally relevant", "fnfbQPjwdqQ-00152-00125780-00126158": "expertise we just wanted to refine the two", "fnfbQPjwdqQ-00153-00126158-00126645": "it has never been done before at the time you needed to know whether androgen", "fnfbQPjwdqQ-00154-00126645-00127176": "receptor antagonists produce mixture effects in a predictable fashion so they", "fnfbQPjwdqQ-00155-00127176-00127623": "were selected these players here's been closed early and flew to might and", "fnfbQPjwdqQ-00156-00127623-00128066": "presume it on these two are pesticides flu Tomatoes a drug they were selected", "fnfbQPjwdqQ-00157-00128066-00128622": "in terms of the effectiveness and their mechanism so this is if you like a lab", "fnfbQPjwdqQ-00158-00128622-00129048": "mixture nothing to do with environmental exposures but this was terribly", "fnfbQPjwdqQ-00159-00129048-00129611": "important to us to verify certain concepts so what you see here is a dose", "fnfbQPjwdqQ-00160-00129611-00130407": "response curve for anal genital index here you see how with those escalation", "fnfbQPjwdqQ-00161-00130407-00131216": "these the offspring gets more and more feminized maybe I know that's fine now", "fnfbQPjwdqQ-00162-00131216-00132047": "this is the outcome of the mixture experiment the green curve is what was", "fnfbQPjwdqQ-00163-00132047-00132491": "anticipated on the basis of these individual dose response curves for a", "fnfbQPjwdqQ-00164-00132491-00133035": "mixture with specific mixture ratio and what you see here these dots are the", "fnfbQPjwdqQ-00165-00133035-00133662": "observations the black dots the outcome from individual litters the red dots the", "fnfbQPjwdqQ-00166-00133662-00134334": "overall litter means and we were quite stunned how well the observations", "fnfbQPjwdqQ-00167-00134334-00135036": "matched what was predicted again this shows that these three androgen receptor", "fnfbQPjwdqQ-00168-00135036-00135732": "antagonists work together in a dose additive fashion so step three we then", "fnfbQPjwdqQ-00169-00135732-00136344": "looked and this paper came out very recently last year in HP just before", "fnfbQPjwdqQ-00170-00136344-00136877": "Christmas we became interested in looking at combinations of antiandrogens", "fnfbQPjwdqQ-00171-00136877-00137570": "that work in a totally that work in by mechanisms that are very different so", "fnfbQPjwdqQ-00172-00137570-00137973": "finasteride for example blocks the conversion of", "fnfbQPjwdqQ-00173-00137973-00138530": "testosterone to dihydrotestosterone I think low saline blocks the", "fnfbQPjwdqQ-00174-00138530-00139200": "unreceptive so we've seen dhp interferes with testosterone synthesis and pro", "fnfbQPjwdqQ-00175-00139200-00139633": "cloris is a mixture it is able to antagonize the under", "fnfbQPjwdqQ-00176-00139633-00139993": "interceptor but also interferes with some important enzyme since de ruyter", "fnfbQPjwdqQ-00177-00139993-00140836": "Genesis what we did was studied the individual dose response curves of all", "fnfbQPjwdqQ-00178-00140836-00141456": "these players again and then mixed at certain ratio and this is what happened", "fnfbQPjwdqQ-00179-00141456-00142114": "with respect to a multitude of endpoints in general distance this is musculus", "fnfbQPjwdqQ-00180-00142114-00142657": "levator Ani that's a funny muscle that's also under the control of androgens in", "fnfbQPjwdqQ-00181-00142657-00143179": "development nipple retention and prostate weight and what you see here in", "fnfbQPjwdqQ-00182-00143179-00143767": "green again are the predicted curves according to dose addition and the blobs", "fnfbQPjwdqQ-00183-00143767-00144448": "here what we observed and again with these layers here that work in a", "fnfbQPjwdqQ-00184-00144448-00144835": "dissimilar fashion there was good agreement with dose", "fnfbQPjwdqQ-00185-00144835-00145444": "addition in this particular case let me say that the Brixton's based on", "fnfbQPjwdqQ-00186-00145444-00145897": "independent action were actually congruent with with those four dose", "fnfbQPjwdqQ-00187-00145897-00146593": "addition no we were very pleased but now comes the one result which throws a", "fnfbQPjwdqQ-00188-00146593-00147222": "spanner in the works and which I personally hate but there it is", "fnfbQPjwdqQ-00189-00147222-00147703": "penile malformations you remember at this very last time point person natal", "fnfbQPjwdqQ-00190-00147703-00148663": "day 47 here we have we constructed a prediction window if you like this is a", "fnfbQPjwdqQ-00191-00148663-00149125": "what we expect on the basis of independent action this is one very", "fnfbQPjwdqQ-00192-00149125-00149842": "conservative prediction based on dose addition so the the and this here in", "fnfbQPjwdqQ-00193-00149842-00150535": "blue is what was really observed so you see a shift towards lower doses with", "fnfbQPjwdqQ-00194-00150535-00151027": "this very endpoint a very important endpoint penile malformation this shift", "fnfbQPjwdqQ-00195-00151027-00151633": "here if you project it down onto the dose axis is is probably not very large", "fnfbQPjwdqQ-00196-00151633-00152242": "it's a factor of four or five base respect to here this is larger is nearly", "fnfbQPjwdqQ-00197-00152242-00152703": "an order of magnitude but what is little disturbed", "fnfbQPjwdqQ-00198-00152703-00153123": "is that in the dose range where basically all the models predict that", "fnfbQPjwdqQ-00199-00153123-00153540": "nothing much should happen the observations show us that we're near", "fnfbQPjwdqQ-00200-00153540-00154200": "maximal effect that is because these dose response curves are so steep we", "fnfbQPjwdqQ-00201-00154200-00154707": "concluded that this is the synergism but we can often no mechanistic explanation", "fnfbQPjwdqQ-00202-00154707-00155070": "as to why this should be when all the other endpoints are essentially does", "fnfbQPjwdqQ-00203-00155070-00155550": "additive maybe there's something about penile development which we don't quite", "fnfbQPjwdqQ-00204-00155550-00156108": "understand also it seems to us that the in this case here", "fnfbQPjwdqQ-00205-00156108-00156729": "the presence of phthalates and other players sensitize the tissue to the", "fnfbQPjwdqQ-00206-00156729-00157185": "effects of vinclozolin vinclozolin is by if I haven't turned the individual dose", "fnfbQPjwdqQ-00207-00157185-00157635": "response cusper in close Alan is the only player in this mixture that will", "fnfbQPjwdqQ-00208-00157635-00158154": "give a complete dose response curve with penile malformations all the others give", "fnfbQPjwdqQ-00209-00158154-00158994": "curves that are sort of stumps a little stumped so as I say we don't like this", "fnfbQPjwdqQ-00210-00158994-00159579": "very much ourselves because it throws a spanner into this predict predictive", "fnfbQPjwdqQ-00211-00159579-00160503": "approach but it has to be reported yes because it's so the the dot there is on", "fnfbQPjwdqQ-00212-00160503-00161097": "the high level is the the mean the sample mean yeah and the bar is what", "fnfbQPjwdqQ-00213-00161097-00161571": "that these are confidence intervals confidence intervals how many", "fnfbQPjwdqQ-00214-00161571-00162216": "observations up in each dose group do you remember yeah quite a few I don't I", "fnfbQPjwdqQ-00215-00162216-00162927": "don't remember off the top of my head but we normally looked at between 6 and", "fnfbQPjwdqQ-00216-00162927-00163548": "10 litters and each litter has five male offspring but some of them were", "fnfbQPjwdqQ-00217-00163548-00164013": "sacrificed before that so I really have to look it up how many but I'm just", "fnfbQPjwdqQ-00218-00164013-00164472": "wondering because in the previous slides you had dots for actual observations", "fnfbQPjwdqQ-00219-00164472-00164969": "yeah the actual observations here did that were there some animals that were", "fnfbQPjwdqQ-00220-00164969-00165428": "lower or did they all sort of cluster up with the confidence interval well they", "fnfbQPjwdqQ-00221-00165428-00165888": "clustered up pretty much here you know otherwise he wouldn't get you know you", "fnfbQPjwdqQ-00222-00165888-00166092": "didn't have at this point you didn't have", "fnfbQPjwdqQ-00223-00166092-00167259": "an animal that was down here okay so just a resume a of what we found so far", "fnfbQPjwdqQ-00224-00167259-00167676": "that we've also I'm not showing you this here we've done a lot of work with", "fnfbQPjwdqQ-00225-00167676-00168381": "mixtures of Eastern any chemicals and in vitro also with fish so we have joint", "fnfbQPjwdqQ-00226-00168381-00168852": "effects with mixed mode of action antiandrogens and that's quite important", "fnfbQPjwdqQ-00227-00168852-00169326": "because there's this myth out there in the regulatory world and otherwise that", "fnfbQPjwdqQ-00228-00169326-00169812": "says people think that combination effects are only to be expected with", "fnfbQPjwdqQ-00229-00169812-00170556": "chemicals that show a similar mode of action this is evidently not borne out", "fnfbQPjwdqQ-00230-00170556-00171273": "by our empirical observations combined effects are always greater than the", "fnfbQPjwdqQ-00231-00171273-00171993": "effects of the most toxic chemical in the mixture and this leads us to think", "fnfbQPjwdqQ-00232-00171993-00172602": "that the usual chemical biochemical approach to risk assessment may lead to", "fnfbQPjwdqQ-00233-00172602-00173322": "under estimations of risks I say may not necessarily in all cases but we can", "fnfbQPjwdqQ-00234-00173322-00174104": "define parameters we're under estimations of risks are likely that's", "fnfbQPjwdqQ-00235-00174104-00174887": "particularly when we're dealing with mixtures of many components more than 10", "fnfbQPjwdqQ-00236-00174950-00175743": "right let's these are what follows now this is the empirical results I thought", "fnfbQPjwdqQ-00237-00175743-00176307": "it might be useful so you have a feel of what's possible now in the area of", "fnfbQPjwdqQ-00238-00176307-00176925": "mixture toxicology now the question how can we approach reality and how can we", "fnfbQPjwdqQ-00239-00176925-00177582": "make use of that in risk assessment when you want to do this the first question", "fnfbQPjwdqQ-00240-00177582-00178131": "we have to face is how are we grouping chemicals which chemicals do you want to", "fnfbQPjwdqQ-00241-00178131-00178860": "consider together in risk assessment there are mechanistic criteria so that's", "fnfbQPjwdqQ-00242-00178860-00179469": "out there that's very much discussed by EPA by other regulatory", "fnfbQPjwdqQ-00243-00179469-00180144": "agencies in Europe you can say I group chemicals that show a similar mechanism", "fnfbQPjwdqQ-00244-00180144-00180729": "a mode of action but the question then is how narrow do you want to be and what", "fnfbQPjwdqQ-00245-00180729-00181332": "precisely do you mean by mode of action does a discussion about it to a large", "fnfbQPjwdqQ-00246-00181332-00182090": "degree pretty fruitless in my opinion the alternative would be to adapt a", "fnfbQPjwdqQ-00247-00182090-00182910": "phenomenological criterion by saying pretty regardless of mechanisms or the", "fnfbQPjwdqQ-00248-00182910-00183507": "details of mechanisms we should group according to similar adverse outcomes so", "fnfbQPjwdqQ-00249-00183507-00184038": "this is for example the approach that the solid report of the National", "fnfbQPjwdqQ-00250-00184038-00184527": "Research Council has taken so the question then becomes which chemicals", "fnfbQPjwdqQ-00251-00184527-00185127": "can cause D muscular D masculinizing effects in male offspring and let's", "fnfbQPjwdqQ-00252-00185127-00185645": "group those together regardless of the details of mechanism and mode of action", "fnfbQPjwdqQ-00253-00185645-00186564": "the question then is that concerns a lot of people are we not casting the net too", "fnfbQPjwdqQ-00254-00186564-00187284": "wide here so that this is a dilemma either you're probably too narrow or too", "fnfbQPjwdqQ-00255-00187284-00187875": "wide let me just highlight this if you if you do it if you overdo it with", "fnfbQPjwdqQ-00256-00187875-00188331": "mechanistic criteria you will always find arguments we're not even", "fnfbQPjwdqQ-00257-00188331-00188874": "combinations of highlights are regarded as sufficiently similar to Warren joint", "fnfbQPjwdqQ-00258-00188874-00189570": "assessment and I think then it becomes absurd there's always slight differences", "fnfbQPjwdqQ-00259-00189570-00190296": "in the molecular mechanisms of our solids act in this kind of system so a", "fnfbQPjwdqQ-00260-00190296-00190914": "grouping like that would be if it's too narrow it would lack credibility on the", "fnfbQPjwdqQ-00261-00190914-00191643": "other hand how wide do we want to cast the net this is in my opinion one of the", "fnfbQPjwdqQ-00262-00191643-00192351": "most difficult questions in mixed of toxicology today to define on a sound", "fnfbQPjwdqQ-00263-00192351-00192961": "scientific basis good grouping criteria for cumulative risk assessment", "fnfbQPjwdqQ-00264-00193000-00193609": "so this grouping has to be plausible and credible I'll give you one example I", "fnfbQPjwdqQ-00265-00193609-00194221": "mentioned this every now and then for example US EPA groups organophosphates", "fnfbQPjwdqQ-00266-00194221-00194594": "carbamide style carbamates and dice AIA carbamates", "fnfbQPjwdqQ-00267-00194594-00195169": "in separate assessment groups for cumulative risk assessment when", "fnfbQPjwdqQ-00268-00195169-00195763": "essentially all these chemicals work by the same mechanism ie", "fnfbQPjwdqQ-00269-00195763-00196318": "inhibiting acetylcholine esterase so in my opinion that's an example of a", "fnfbQPjwdqQ-00270-00196318-00197023": "grouping strategy that lacks both credibility and scientific plausibility", "fnfbQPjwdqQ-00271-00197116-00197663": "so how can we make headway with these antiandrogens and the thyroids and", "fnfbQPjwdqQ-00272-00197663-00198269": "here's an insight by someone called Earl Grey who whenever asked says the", "fnfbQPjwdqQ-00273-00198269-00198881": "developing tissue does not care by which mechanism fetal under an action is", "fnfbQPjwdqQ-00274-00198881-00199151": "compromised whether by suppression of androgen", "fnfbQPjwdqQ-00275-00199151-00199754": "synthesis or antagonism at the receptor the outcome is the same and that opens", "fnfbQPjwdqQ-00276-00199754-00200300": "the door this is a biological or we call it physiologically based grouping", "fnfbQPjwdqQ-00277-00200300-00201080": "criterion instead of getting so hung up about mechanisms so here's a chart which", "fnfbQPjwdqQ-00278-00201080-00201731": "appears in the NRC report so here we have phthalates other anti-androgen", "fnfbQPjwdqQ-00279-00201731-00202397": "compounds other risk factors through this funnel if they all act on and run", "fnfbQPjwdqQ-00280-00202397-00202922": "action the outcome is altered male reproductive outcomes and this has to be", "fnfbQPjwdqQ-00281-00202922-00203732": "taken into consideration so here's a proposal for grouping of course favorite", "fnfbQPjwdqQ-00282-00203732-00204496": "chemical to the phthalates have to show up but here's a list of pesticides that", "fnfbQPjwdqQ-00283-00204496-00205229": "many of which act at the andron receptor level we have environmental chemicals", "fnfbQPjwdqQ-00284-00205229-00205844": "that show evidence of anti Anisa TPP DD years if you like a classic one", "fnfbQPjwdqQ-00285-00205844-00206498": "certain PCBs show these affect certain dioxins and furans as well and then", "fnfbQPjwdqQ-00286-00206498-00206992": "there are others certain parabens for example there in vitro and receptor", "fnfbQPjwdqQ-00287-00206992-00208103": "antagonists UV filter substances and and some others so I've now I'm moving", "fnfbQPjwdqQ-00288-00208103-00208769": "towards my example of how this could be played out but before I should lay my", "fnfbQPjwdqQ-00289-00208769-00209201": "cards on the table in terms of risk assessment approaches and this we", "fnfbQPjwdqQ-00290-00209201-00209789": "touched on yesterday there are two fundamentally different approaches to", "fnfbQPjwdqQ-00291-00209789-00210239": "risk assessment they've been discussed by Glenn Souter at length he's written", "fnfbQPjwdqQ-00292-00210239-00210830": "many useful papers about this there's one first of all risks essman to protect", "fnfbQPjwdqQ-00293-00210830-00211319": "human populations in the sense you know we want this deterministic risk", "fnfbQPjwdqQ-00294-00211319-00211921": "certainly we want to know does the red light begin to flicker or not and this", "fnfbQPjwdqQ-00295-00211921-00212536": "kind of risk assessment art of necessity has to have a bias towards conservatism", "fnfbQPjwdqQ-00296-00212536-00213194": "in case of uncertainty and that is necessary to protect human populations", "fnfbQPjwdqQ-00297-00213194-00214066": "the aim is mostly to evaluate is there a case for action this has to be", "fnfbQPjwdqQ-00298-00214066-00214684": "contrasted with and may not be confused with a quantitative risk assessment", "fnfbQPjwdqQ-00299-00214684-00215369": "where the aim is really to assess the magnitude of a health impact at current", "fnfbQPjwdqQ-00300-00215369-00215857": "exposure levels that's some it's of course the two approaches are related", "fnfbQPjwdqQ-00301-00215857-00216459": "somewhat but it is different and both approaches use different methods to", "fnfbQPjwdqQ-00302-00216459-00217021": "contrast this the quantitative risk assessment approach would very much rely", "fnfbQPjwdqQ-00303-00217021-00217771": "on probabilistic methods and approaches the question is and our kites are", "fnfbQPjwdqQ-00304-00217771-00218332": "actually sufficient data at hand to move towards quantitative risk assessment and", "fnfbQPjwdqQ-00305-00218332-00218831": "to cut a long story short I don't think there are so what follows is very much", "fnfbQPjwdqQ-00306-00218831-00219350": "in the camp of this determinist dick risk-assessment we started doing", "fnfbQPjwdqQ-00307-00219350-00220013": "this myself and my collaborator and friend Michelle Faust just in order to", "fnfbQPjwdqQ-00308-00220013-00220646": "see let's use the information that's out there and will this kind of cumulative", "fnfbQPjwdqQ-00309-00220646-00221392": "risk assessment lead to the answer hmm is there a case to answer or not with", "fnfbQPjwdqQ-00310-00221392-00222239": "the TDs and the role of chemical exposures so the how can this be done we", "fnfbQPjwdqQ-00311-00222239-00222983": "are all familiar with the classic single chemical approach you make you divide", "fnfbQPjwdqQ-00312-00222983-00223487": "intake estimates by what you think is a tolerable daily intake and if this", "fnfbQPjwdqQ-00313-00223487-00224030": "quotient is smaller than one everyone is happy", "fnfbQPjwdqQ-00314-00224030-00224494": "there is an approach which is called the hazard index approach to cumulative risk", "fnfbQPjwdqQ-00315-00224494-00225244": "assessment which builds on this and uses the same quotients if you like that's a", "fnfbQPjwdqQ-00316-00225244-00225671": "hazard question but does this for every chemical in the mixture", "fnfbQPjwdqQ-00317-00225671-00226337": "the demand is then that each the sum of each of these questions here should also", "fnfbQPjwdqQ-00318-00226337-00226969": "be smaller than one that's an approach D has an index approach that has been", "fnfbQPjwdqQ-00319-00226969-00227489": "widely used and is still widely used by us epi for example for the assessment of", "fnfbQPjwdqQ-00320-00227489-00228161": "Superfund sites normally what they do with Superfund sites that the demand is", "fnfbQPjwdqQ-00321-00228161-00228821": "that these tolerable daily intakes does not necessarily have to be related to", "fnfbQPjwdqQ-00322-00228821-00229379": "the same endpoint or health outcome they they sum up across totally different", "fnfbQPjwdqQ-00323-00229379-00229991": "endpoints but we thought we can't do this in this case let's utilize this", "fnfbQPjwdqQ-00324-00229991-00230600": "approach and sum up over endpoints relevant to an tiandra Nissa t so let's", "fnfbQPjwdqQ-00325-00230600-00231458": "not mix up apples with pears really it's the for the mutton Chris I put this in", "fnfbQPjwdqQ-00326-00231458-00232402": "for you right so in selecting in making a list of", "fnfbQPjwdqQ-00327-00232402-00232888": "chemicals we want to subject to the hazard index approach we had to reflect", "fnfbQPjwdqQ-00328-00232888-00233401": "on an effect criterion and what we chose work only chemicals with in vivo", "fnfbQPjwdqQ-00329-00233401-00234078": "evidence of auntie and Rona city we disregarded all in vitro antiandrogens", "fnfbQPjwdqQ-00330-00234159-00234688": "exposure information had to be available as well and let me tell you these two", "fnfbQPjwdqQ-00331-00234688-00235223": "criteria which probably seem very straightforward and trivial to you", "fnfbQPjwdqQ-00332-00235223-00235869": "already proved to be very restrictive a lot of chemicals had to be thrown out", "fnfbQPjwdqQ-00333-00235869-00236851": "for a stunning lack of information if possible our goal was to distinguish", "fnfbQPjwdqQ-00334-00236851-00237757": "between median exposures and high exposures so here's the first list these", "fnfbQPjwdqQ-00335-00237757-00238321": "are the chemicals which we selected I I hope you can see it it's a little small", "fnfbQPjwdqQ-00336-00238321-00239002": "but I'll talk you through is these are the chemicals we have five phthalates we", "fnfbQPjwdqQ-00337-00239002-00239646": "have think lot Olympic rowers prosimian linear infinite rasayan here these are", "fnfbQPjwdqQ-00338-00239646-00240315": "well-documented anti-androgen syn river and finally PPD de down here the effect", "fnfbQPjwdqQ-00339-00240315-00240841": "looked at or taken into account here was suppression of fetal testosterone", "fnfbQPjwdqQ-00340-00240841-00241494": "synthesis retained nipples for the pesticides mostly changes in annual", "fnfbQPjwdqQ-00341-00241494-00242005": "gentle distance for finito Scion and retained nipples in male offspring for", "fnfbQPjwdqQ-00342-00242005-00243010": "PPD de now here is what I would like to define as point of departure but for", "fnfbQPjwdqQ-00343-00243010-00243784": "anti hundred and end points not for anything these this so this is derived", "fnfbQPjwdqQ-00344-00243784-00244411": "from experimental studies for example how to sell so that's either measures a", "fnfbQPjwdqQ-00345-00244411-00244903": "point of departure could be either a benchmark dose or no observed effect", "fnfbQPjwdqQ-00346-00244903-00245357": "concentration orders here's an uncertainty factor and he", "fnfbQPjwdqQ-00347-00245357-00245921": "already the second limitation it turns out that many of these studies in fact", "fnfbQPjwdqQ-00348-00245921-00246644": "were scientific exploratory studies not designed to estimate very low effects so", "fnfbQPjwdqQ-00349-00246644-00247316": "yeah but the information was out there we took account of this by combining", "fnfbQPjwdqQ-00350-00247316-00247862": "then by using an uncertainty factor larger than hundred normally hundred you", "fnfbQPjwdqQ-00351-00247862-00248689": "use to define a reference dose but in hundred we've used here for these", "fnfbQPjwdqQ-00352-00248689-00249233": "pesticides so by combining those point of departures from animal experiments", "fnfbQPjwdqQ-00353-00249233-00249752": "with uncertainty factors we arrived at what we call reference dose for anti and", "fnfbQPjwdqQ-00354-00249752-00250351": "Rona city in microgram per kilo and de and here are the references let me say", "fnfbQPjwdqQ-00355-00250351-00250867": "this was important to us as well in order to avoid comparing apples with", "fnfbQPjwdqQ-00356-00250867-00251469": "pears let's look at finito si on finito a Scion if you like has an official Adi", "fnfbQPjwdqQ-00357-00251469-00251969": "which in fact is lower than the reference dose for anti Andrew Nyssa T", "fnfbQPjwdqQ-00358-00251969-00252446": "which we took into account here because fenêtre son is also a neurotoxin and", "fnfbQPjwdqQ-00359-00252446-00253171": "neurotoxicity occurs at doses lower than anti and Renick effects so we have not", "fnfbQPjwdqQ-00360-00253171-00253923": "taken the IDI for finito SIA in order we feel that would have muddied the waters", "fnfbQPjwdqQ-00361-00253923-00254723": "okay these here's the second selection it becomes a little hazy here and here", "fnfbQPjwdqQ-00362-00254723-00255434": "you see already there problems here's a flame retardant BD e99 there is one", "fnfbQPjwdqQ-00363-00255434-00255821": "paper that describes suppression of testosterone levels and reductions in", "fnfbQPjwdqQ-00364-00255821-00256717": "energy of distance in male offspring only only one study bisphenol A there", "fnfbQPjwdqQ-00365-00256717-00257258": "are some studies in Japan that described decrease testosterone levels in male", "fnfbQPjwdqQ-00366-00257258-00257900": "offspring but not very well documented and then propyl and butyl paraben again", "fnfbQPjwdqQ-00367-00257900-00258328": "here suppression of testosterone levels decreased epididymis weights and", "fnfbQPjwdqQ-00368-00258328-00258782": "decreases in spam reduction but in general these these", "fnfbQPjwdqQ-00369-00258782-00259336": "chemicals the evidence for anti under Nyssa t I would regard us fairly limited", "fnfbQPjwdqQ-00370-00259336-00260078": "the data could be better nevertheless just to try out how far we get with this", "fnfbQPjwdqQ-00371-00260078-00261257": "we included those chemicals as well then intake values and okay now here is the", "fnfbQPjwdqQ-00372-00261257-00261962": "first attempt to cut a long story short if we carry out this exercise cumulative", "fnfbQPjwdqQ-00373-00261962-00262523": "risk assessment using the hazard index approach for median intakes on the basis", "fnfbQPjwdqQ-00374-00262523-00263105": "of 15 chemicals the answer is there's probably not a case to answer because", "fnfbQPjwdqQ-00375-00263105-00263899": "the hazard index the sum of hazard questions here is 0.38 smaller than one", "fnfbQPjwdqQ-00376-00263899-00264551": "let me just talk you through this table so here you see those chemicals here's", "fnfbQPjwdqQ-00377-00264551-00265139": "the median intake the next column is the reference dose for aunty under Nyssa T", "fnfbQPjwdqQ-00378-00265139-00265742": "the hazard current is just intake divided by reference dose here you make", "fnfbQPjwdqQ-00379-00265742-00266393": "the sum and here we constructed the ratio of the hazard question to the", "fnfbQPjwdqQ-00380-00266393-00266972": "overall hazard index and because it's 15 chemicals if they all contributed", "fnfbQPjwdqQ-00381-00266972-00267602": "equally you would expect this to be around 5% highlighted in gray are those", "fnfbQPjwdqQ-00382-00267602-00268223": "that contribute more so this is a wonderful tool for prioritization all of", "fnfbQPjwdqQ-00383-00268223-00268874": "a sudden you see which chemicals are important players and which ones do not", "fnfbQPjwdqQ-00384-00268874-00269945": "contribute a lot to the hazard index so for example these here DBP dhp those", "fnfbQPjwdqQ-00385-00269945-00270485": "pesticides and butyl paraben after say something about this later", "fnfbQPjwdqQ-00386-00270485-00271154": "contribute disproportionally to the overall hazard index but for example not", "fnfbQPjwdqQ-00387-00271154-00271680": "PPD de not brominated flame retardants lots of people are hung up", "fnfbQPjwdqQ-00388-00271680-00272307": "about brominated flame retardants and auntie Angela City interesting the human", "fnfbQPjwdqQ-00389-00272307-00273030": "mind without eight cannot easily aggregate prevalence and potency so you", "fnfbQPjwdqQ-00390-00273030-00273825": "but this is a wonderful aid to do this and a tool for prioritization okay let's", "fnfbQPjwdqQ-00391-00273825-00274454": "look at high exposures and here the story changes and in the interest of", "fnfbQPjwdqQ-00392-00274454-00274899": "determinist deterministic risk assessment we have to take this account", "fnfbQPjwdqQ-00393-00274899-00275751": "we're constructing a worst case again here similar construction high intake", "fnfbQPjwdqQ-00394-00275751-00276345": "reference doses hazard person and here the relative contribution what we see", "fnfbQPjwdqQ-00395-00276345-00277020": "here is the D H P is important probably DB p as well", "fnfbQPjwdqQ-00396-00277020-00277824": "all those pesticides bisphenol a butyl paraben propel paraben however what", "fnfbQPjwdqQ-00397-00277824-00278484": "worries me is that with bisphenol a butyl and propel paraben both the intake", "fnfbQPjwdqQ-00398-00278484-00279332": "estimates and the potency estimates are very shaky however the overall sum is", "fnfbQPjwdqQ-00399-00279332-00279987": "2.0 one that's probably over accurate so let's say two and you see here butyl", "fnfbQPjwdqQ-00400-00279987-00280605": "paraben alone contributes fifty percent so we could say let's take Beauty power", "fnfbQPjwdqQ-00401-00280605-00281034": "been out for the sake of the argument because the quality of data is not very", "fnfbQPjwdqQ-00402-00281034-00281577": "good we would still be left with something quite close to one which I", "fnfbQPjwdqQ-00403-00281577-00282347": "would conclude to mean maybe we should be a bit careful we've then carried out", "fnfbQPjwdqQ-00404-00282347-00282963": "well that's a summary here for high intakes we have seven chemicals", "fnfbQPjwdqQ-00405-00282963-00283455": "explained more than ninety percent of an expected combination effect there's poor", "fnfbQPjwdqQ-00406-00283455-00284079": "data quality for bisphenol A the same for paraben and they surprise to us if", "fnfbQPjwdqQ-00407-00284079-00284487": "we compare intake values was that flame retardants and people dealing you", "fnfbQPjwdqQ-00408-00284487-00285039": "contribute very little this is goes against the grain of", "fnfbQPjwdqQ-00409-00285039-00285792": "the hobby chemicals of many people in this area but now we have to have a an", "fnfbQPjwdqQ-00410-00285792-00286548": "uncertainty analysis we asked ourselves and you see here the Empire State", "fnfbQPjwdqQ-00411-00286548-00287576": "Building gets little hazy what are factors that decrease our risk estimate", "fnfbQPjwdqQ-00412-00287576-00288080": "and definitely the first one is the question of combinatorial exposures we", "fnfbQPjwdqQ-00413-00288080-00288663": "have assumed in this worst case that everyone is or know that certain people", "fnfbQPjwdqQ-00414-00288663-00289263": "are exposed to the high end now how likely is this really that someone high", "fnfbQPjwdqQ-00415-00289263-00289979": "in solids is also high in pesticides we don't know for a lack of data what would", "fnfbQPjwdqQ-00416-00289979-00290592": "need it would be needed to address this would be that we have samples from one", "fnfbQPjwdqQ-00417-00290592-00291109": "at the same person analyzed for multiple chemicals these data are not available", "fnfbQPjwdqQ-00418-00291109-00291813": "but surely I think it can be argued that community oral exposures would actually", "fnfbQPjwdqQ-00419-00291813-00292473": "decrease our risk estimates against this we have to balance factors that way", "fnfbQPjwdqQ-00420-00292473-00293255": "we'll definitely increase our risk estimates and these are first of all my", "fnfbQPjwdqQ-00421-00293255-00293750": "worries are that we are dealing with an incomplete set of chemicals if you", "fnfbQPjwdqQ-00422-00293750-00294436": "remember the selection criteria which we set ourselves meant that very definitely", "fnfbQPjwdqQ-00423-00294436-00294945": "we had to leave out some chemicals where there are some suspicions of auntie and", "fnfbQPjwdqQ-00424-00294945-00295689": "Rina City so if we had better data and our data gaps and if we included those", "fnfbQPjwdqQ-00425-00295689-00296193": "as well the risk estimate would go up again the hazard index would increase", "fnfbQPjwdqQ-00426-00296193-00296949": "that secondly I have some concerns about under estimations of potency you", "fnfbQPjwdqQ-00427-00296949-00297423": "remember when I explained how we arrived at those reference doses for Aunty and", "fnfbQPjwdqQ-00428-00297423-00297927": "Rona city many of these studies who are really not designed", "fnfbQPjwdqQ-00429-00297927-00298658": "to estimate no observed effect levels or benchmarks and my concern is that really", "fnfbQPjwdqQ-00430-00298658-00299241": "those risk estimates in future studies better conducted studies might actually", "fnfbQPjwdqQ-00431-00299241-00299979": "show that where we are lower that would increase our risk estimates as well so", "fnfbQPjwdqQ-00432-00299979-00300594": "you can see this oh by the way just you probably guessed it with all this we've", "fnfbQPjwdqQ-00433-00300594-00301215": "made the assumption that the exposure of women in the reproductive age is very", "fnfbQPjwdqQ-00434-00301215-00301617": "similar to that of the general population I think that's a fair", "fnfbQPjwdqQ-00435-00301617-00302413": "assumption really we want to protect the male fetus so here if you we go back to", "fnfbQPjwdqQ-00436-00302413-00302955": "the formula for hazard indices you can see mathematically how this plays out so", "fnfbQPjwdqQ-00437-00302955-00303603": "we have the exposure levels here if they go up then the hazard index will", "fnfbQPjwdqQ-00438-00303603-00304380": "increase the acceptable levels for single chemicals if they go down hazard", "fnfbQPjwdqQ-00439-00304380-00304908": "index will increase and finally that worries me a lot the total number of", "fnfbQPjwdqQ-00440-00304908-00305559": "chemicals that go into this formula here n we restricted ourselves to 15 what", "fnfbQPjwdqQ-00441-00305559-00306210": "will happen if we have better data for more potential antiandrogens which will", "fnfbQPjwdqQ-00442-00306210-00307020": "enable us to put these into this formula as well well for help we can turn to", "fnfbQPjwdqQ-00443-00307020-00307663": "this man and reflect a little unknown unknowns the in vitro under nan tagging", "fnfbQPjwdqQ-00444-00307663-00308478": "and receptor antagonists our lab we are pursuing this with vigor in our lamp we", "fnfbQPjwdqQ-00445-00308478-00309117": "are testing quite a few chemicals and a lot of surprises happen there is at", "fnfbQPjwdqQ-00446-00309117-00309765": "least 35 pesticides in use which we know of our hundred receptor antagonists in", "fnfbQPjwdqQ-00447-00309765-00310539": "vitro there is UV filter substances they are too and certain dioxins and furans", "fnfbQPjwdqQ-00448-00310539-00311185": "the question really is you know as well as I how expensive it is to do", "fnfbQPjwdqQ-00449-00311185-00311701": "a an in vitro developmental toxicity study do we really want to test all of", "fnfbQPjwdqQ-00450-00311701-00312307": "these in these models it would be very expensive on the other hand there's this", "fnfbQPjwdqQ-00451-00312307-00312880": "information out there about a lot of in vitro and receptor antagonists what do", "fnfbQPjwdqQ-00452-00312880-00313110": "we do", "fnfbQPjwdqQ-00453-00313146-00313789": "the most serious stumbling block in my opinion is this poor and fragmentary", "fnfbQPjwdqQ-00454-00313789-00314359": "information about exposure levels for example about the paraben so a crude", "fnfbQPjwdqQ-00455-00314359-00315013": "estimates about exposures done by European scientific committees but we're", "fnfbQPjwdqQ-00456-00315013-00315906": "not sure better data are needed so to conclude I believe that the hazard index", "fnfbQPjwdqQ-00457-00315906-00316477": "approach is a is a good tool and probably the best we can use at the", "fnfbQPjwdqQ-00458-00316477-00317047": "moment to make headway with at least Popeye oriT izing chemicals in in this", "fnfbQPjwdqQ-00459-00317047-00317551": "area and for making headway with getting a feel for whether there actually might", "fnfbQPjwdqQ-00460-00317551-00318160": "be a case to answer or not we it's a it's a powerful tool also to identify", "fnfbQPjwdqQ-00461-00318160-00318703": "knowledge gaps and I couldn't anticipate that before we did this and have to say", "fnfbQPjwdqQ-00462-00318703-00319216": "I was a little surprised about some knowledge gaps there are loads of", "fnfbQPjwdqQ-00463-00319216-00319846": "pesticides out there but quite frankly they're in use and there are no in vivo", "fnfbQPjwdqQ-00464-00319846-00320533": "data about anti-drone City nothing industry has got away with not providing", "fnfbQPjwdqQ-00465-00320533-00321318": "these data we can also use this to direct epidemiological research so", "fnfbQPjwdqQ-00466-00321318-00321754": "epidemiologists might be interested in this and saying right we can tell them", "fnfbQPjwdqQ-00467-00321754-00322215": "rather than looking at your favorite chemical for example there the", "fnfbQPjwdqQ-00468-00322215-00322693": "environmental epidemiology in this area is littered with studies where only the", "fnfbQPjwdqQ-00469-00322693-00323236": "effects of PPD de on hypospadias and similar things were studied this", "fnfbQPjwdqQ-00470-00323236-00323842": "consideration shows us that epidemiology has probably been barking up the wrong", "fnfbQPjwdqQ-00471-00323842-00324441": "tree for a long time and instead should focus on some other chemicals", "fnfbQPjwdqQ-00472-00324495-00325341": "it may also be used to focus regulatory action so to conclude I would say we can", "fnfbQPjwdqQ-00473-00325341-00325911": "we can try out cumulative risk assessment it is better than anything", "fnfbQPjwdqQ-00474-00325911-00326678": "that happens today simply by pursuing single chemicals anything", "fnfbQPjwdqQ-00475-00326678-00327426": "considering mixtures is better than the status quo and with this I'd like to", "fnfbQPjwdqQ-00476-00327426-00328244": "thank you and thank you", "fnfbQPjwdqQ-00477-00328802-00330674": "but do we any questions comments okay I have a couple of questions in the", "fnfbQPjwdqQ-00478-00330674-00331428": "experiments were you looking at the mixtures you make a mixture or Earl Grey", "fnfbQPjwdqQ-00479-00331428-00331967": "or somebody of you know maybe half a dozen chemicals they're roughly", "fnfbQPjwdqQ-00480-00331967-00332541": "generally roughly at equipo doses is that correct yeah these are what we call", "fnfbQPjwdqQ-00481-00332541-00333288": "the the if you like lab designer mixtures here where the aim is to to", "fnfbQPjwdqQ-00482-00333288-00334017": "refine prediction tools to see whether we can really anticipate the effect this", "fnfbQPjwdqQ-00483-00334017-00334521": "is so necessary to do so because you have to safeguard against the danger", "fnfbQPjwdqQ-00484-00334521-00334866": "that really you don't do a mixture experiment although you put some", "fnfbQPjwdqQ-00485-00334866-00335364": "chemicals together and that's the case when maybe one or only a few players", "fnfbQPjwdqQ-00486-00335364-00336102": "dominate that's absolutely and also you're doing experiments as at doses", "fnfbQPjwdqQ-00487-00336102-00336726": "where you have very measurable effects and my question is after after reading", "fnfbQPjwdqQ-00488-00336726-00337326": "that that chapter and the NRC report what happens as you move away from that", "fnfbQPjwdqQ-00489-00337326-00337863": "sort of middle ground the exposures get lower where you know", "fnfbQPjwdqQ-00490-00337863-00338450": "humans exposures are not at the fifth thank God at the 50% effect level there", "fnfbQPjwdqQ-00491-00338450-00339474": "somewhere lower and where the mixtures maybe a little more skewed does do you", "fnfbQPjwdqQ-00492-00339474-00339964": "think that what's likely to happen tis will additive 'ti do you think dose a", "fnfbQPjwdqQ-00493-00339964-00340647": "Nativity will still apply or do you think it may be less than dose additive", "fnfbQPjwdqQ-00494-00340647-00341427": "and the I haven't shown this but we've also nested in some of these studies", "fnfbQPjwdqQ-00495-00341427-00341992": "we've done what we call our something from nothing experiment where for", "fnfbQPjwdqQ-00496-00341992-00342528": "example with the mixture of 300 receptor antagonists in vivo it was possible to", "fnfbQPjwdqQ-00497-00342528-00343178": "define an observed adverse effect level and we then deliberately directly", "fnfbQPjwdqQ-00498-00343178-00343599": "combined the three chemicals at precisely that dose to see is there a", "fnfbQPjwdqQ-00499-00343599-00344070": "mixture effect or not and there was and it was predictable well by those", "fnfbQPjwdqQ-00500-00344070-00344853": "addition I'm just thinking with all the chemicals were exposed to and we know", "fnfbQPjwdqQ-00501-00344853-00345742": "that some of a very anti androgenic in up probably a lot we don't know and if", "fnfbQPjwdqQ-00502-00345742-00346515": "it it just seems to be it to me if you keep adding chemicals to your list a", "fnfbQPjwdqQ-00503-00346515-00347097": "it's it's good we're gonna find that the risk is so high I mean it's it would be", "fnfbQPjwdqQ-00504-00347097-00347907": "unbelievably implausibly high and I'm just wondering as you get to lower and", "fnfbQPjwdqQ-00505-00347907-00348667": "lower exposures to more and more chemicals does that you know do you", "fnfbQPjwdqQ-00506-00348667-00349569": "deviate from additive 'ti conceptually no although if someone gives us the", "fnfbQPjwdqQ-00507-00349569-00350154": "money we do the experiments well if you prove positive but it's going to be damn", "fnfbQPjwdqQ-00508-00350154-00350806": "expensive yea we think we I personally don't like doing those experiments that", "fnfbQPjwdqQ-00509-00350806-00351914": "so to prove cons you know I would say if you then move on into theory it is to be", "fnfbQPjwdqQ-00510-00351914-00352461": "expected that if you combine many chemicals at low doses that's if if they", "fnfbQPjwdqQ-00511-00352461-00353128": "then the toxic unit the hazard quotients and up to a suitably high level then you", "fnfbQPjwdqQ-00512-00353128-00353567": "will you will get a mixture effect of course if you look at the mathematics of", "fnfbQPjwdqQ-00513-00353567-00354194": "this you can't anticipate situations where for example if you have very few", "fnfbQPjwdqQ-00514-00354194-00354745": "relevant players combined with relatively low exposures nothing is to", "fnfbQPjwdqQ-00515-00354745-00355466": "be expected but that the answer to that question and I think this is quite", "fnfbQPjwdqQ-00516-00355466-00356035": "important to separate out is not a an issue of mixture toxicology it's it's", "fnfbQPjwdqQ-00517-00356035-00356516": "one off incomplete information about exposures and also the relevant", "fnfbQPjwdqQ-00518-00356516-00357253": "chemicals which we need to take into consideration you know I agree totally", "fnfbQPjwdqQ-00519-00357253-00357901": "that the the issue is on exposure because you know to have all these", "fnfbQPjwdqQ-00520-00357901-00358470": "things at the high levels in any one place in any one time is quite remote", "fnfbQPjwdqQ-00521-00358470-00359311": "and unfortunately when people have done risk assessments using Monte Carlo", "fnfbQPjwdqQ-00522-00359311-00359717": "techniques to take the 95th percentile of everything and they throw it in and", "fnfbQPjwdqQ-00523-00359717-00360106": "say well we got a risk sure of course you do because you've thrown everything", "fnfbQPjwdqQ-00524-00360106-00360566": "into the hopper and you've only looked at the real high end and I think we have", "fnfbQPjwdqQ-00525-00360566-00361054": "to be very careful that we have to look at the realistic probabilities of coming", "fnfbQPjwdqQ-00526-00361054-00361759": "up with some situations where there may be one two or three chemicals that", "fnfbQPjwdqQ-00527-00361759-00362308": "occurred simultaneously because either high production or is there in products", "fnfbQPjwdqQ-00528-00362308-00362701": "that everyone uses every day and their their high levels in those products but", "fnfbQPjwdqQ-00529-00362701-00363211": "for the most part I just don't see where that 90th percentile is gonna come into", "fnfbQPjwdqQ-00530-00363211-00363518": "play in any reality we have one thing going for us", "fnfbQPjwdqQ-00531-00363518-00364004": "because the phalates and Ann Haynes they're measuring a set of", "fnfbQPjwdqQ-00532-00364004-00364940": "phalates yeah and so if you could it it wouldn't be easy to do but I think it", "fnfbQPjwdqQ-00533-00364940-00365393": "could be done if you could count if there were a bio equivalent a", "fnfbQPjwdqQ-00534-00365393-00365972": "biomonitoring equivalent whatever you want to call it if for you know each", "fnfbQPjwdqQ-00535-00365972-00366482": "tally you have a certain metabolite level and if you could apply some", "fnfbQPjwdqQ-00536-00366482-00367247": "adjustment factor that would adjust for not only the pharmacokinetics and then", "fnfbQPjwdqQ-00537-00367247-00367919": "also the potency you could sample individually we can get the download the", "fnfbQPjwdqQ-00538-00367919-00368336": "data from an hain for individuals for individuals if you can download for", "fnfbQPjwdqQ-00539-00368336-00368912": "individuals and you can have the the range of levels in the body you can at", "fnfbQPjwdqQ-00540-00368912-00369443": "least get an idea of how many are present or not but that means you have", "fnfbQPjwdqQ-00541-00369443-00369794": "to download the whole data set because there's so many of these samples in", "fnfbQPjwdqQ-00542-00369794-00370361": "which there's non detects and it's ok is there were that many that were not in", "fnfbQPjwdqQ-00543-00370361-00370706": "the text it depends upon the individual and depends upon the compounds because", "fnfbQPjwdqQ-00544-00370706-00371351": "we're talking about a whole variety of compounds here and I tend to get very", "fnfbQPjwdqQ-00545-00371351-00371822": "discouraged when I see people reporting things like the 97th and 95th and the", "fnfbQPjwdqQ-00546-00371822-00372296": "50th percentile they don't yeah they don't report the 5 and the 2 and the 1", "fnfbQPjwdqQ-00547-00372296-00372713": "percentile which in fact Mary may in fact be there might be a lot of data", "fnfbQPjwdqQ-00548-00372713-00373754": "yeah but but if we knew how to do that I think it's conceptually possible sure it", "fnfbQPjwdqQ-00549-00373754-00374471": "it would be very valuable but we thought about this as well and the problem is", "fnfbQPjwdqQ-00550-00374471-00375032": "one of those metrics yeah if you have information about tissue levels in", "fnfbQPjwdqQ-00551-00375032-00375626": "humans it would be really nice to have the equivalent from animal experiments", "fnfbQPjwdqQ-00552-00375626-00376181": "where where we know that the outcomes our observable but unfortunately there's", "fnfbQPjwdqQ-00553-00376181-00376592": "another data gap we don't I'm currently involved", "fnfbQPjwdqQ-00554-00376592-00376925": "I'm currently coordinating an EU project where we are trying to fill", "fnfbQPjwdqQ-00555-00376925-00377585": "SCAP but that's gonna be a lot of work but there's only one hint of what might", "fnfbQPjwdqQ-00556-00377585-00378296": "come there's a study by RI where they looked at where they gave salads to the", "fnfbQPjwdqQ-00557-00378296-00379088": "female rats and measured in the amniotic fluid the thyroid levels and compared to", "fnfbQPjwdqQ-00558-00379088-00379706": "what's measurable in amniotic fluid in humans and when observed when they found", "fnfbQPjwdqQ-00559-00379706-00380284": "effects in the rat imagine of exposure on that dose metric was frightening", "fnfbQPjwdqQ-00560-00380284-00381155": "frightening Li small but that was done only for two single chemicals yeah but", "fnfbQPjwdqQ-00561-00381155-00381620": "this is the kind of stuff we would need and then you know human tissue levels", "fnfbQPjwdqQ-00562-00381620-00382013": "would come to life and we could use them at the moment I find this difficult", "fnfbQPjwdqQ-00563-00382013-00382589": "because we haven't got the information from the animal experiments to use a", "fnfbQPjwdqQ-00564-00382589-00383147": "read across or a parallelogram oh you mean like even comparing a rat", "fnfbQPjwdqQ-00565-00383147-00383699": "urinary level to a human urinary level that's not possible I don't think that's", "fnfbQPjwdqQ-00566-00383699-00383927": "possible at this time in fact I think there would", "fnfbQPjwdqQ-00567-00383927-00384478": "be kind of dangerous in terms of coming up with any kind of reasonable", "fnfbQPjwdqQ-00568-00384478-00385028": "assessments oh no I wouldn't think it's dangerous someone needs to do it and see", "fnfbQPjwdqQ-00569-00385028-00385667": "what using the data I mean again it's biomarkers and their own writer of", "fnfbQPjwdqQ-00570-00385667-00386246": "single points in time and and I don't think unless we have time series that we", "fnfbQPjwdqQ-00571-00386246-00386750": "have any way of using that effectively for a risk assessment which which we're", "fnfbQPjwdqQ-00572-00386750-00387185": "talking about a risk assessment not for just one day in the life but over a year", "fnfbQPjwdqQ-00573-00387185-00387731": "or maybe even 70 years so they really we really have to be really careful how we", "fnfbQPjwdqQ-00574-00387731-00388286": "extrapolate these numbers yes absolutely why I mean I look at it like you said", "fnfbQPjwdqQ-00575-00388286-00389069": "it's a snapshot but it's of a large population so is it any different from", "fnfbQPjwdqQ-00576-00389069-00389402": "looking at one person yes from day to day", "fnfbQPjwdqQ-00577-00389402-00389916": "absolutely absolutely it's different from day to day", "fnfbQPjwdqQ-00578-00389916-00390499": "well for an individual's population about think about use of pesticides I", "fnfbQPjwdqQ-00579-00390499-00391292": "mean in the United States if you have people who have you know farms gardens", "fnfbQPjwdqQ-00580-00391292-00391874": "people who have pests in the home and they spray their own houses they they", "fnfbQPjwdqQ-00581-00391874-00392439": "will have periodic exposures and those exposures will lead to levels in the in", "fnfbQPjwdqQ-00582-00392439-00393015": "the body that will be decreased over time and so you sample a person at time", "fnfbQPjwdqQ-00583-00393015-00393447": "X you find nothing you'd sample of time why you find levels that are through the", "fnfbQPjwdqQ-00584-00393447-00393969": "roof it doesn't mean that you will have characterized that individuals exposure", "fnfbQPjwdqQ-00585-00393969-00394409": "and you're using a general population study sure it gives you statistical", "fnfbQPjwdqQ-00586-00394409-00394808": "distribution of the mean but not the people who eat the high end or the low", "fnfbQPjwdqQ-00587-00394808-00395479": "end so you really gotta be careful how you extrapolate that data you really do", "fnfbQPjwdqQ-00588-00395578-00395953": "you think the goodness of fit that you've seen here is unique to", "fnfbQPjwdqQ-00589-00395953-00396518": "anti-angiogenic activity or might you find it with other hormonal activities", "fnfbQPjwdqQ-00590-00396518-00397208": "or even more distantly non hormonal mechanisms of action I'm not sure I", "fnfbQPjwdqQ-00591-00397208-00397835": "understand your question goodness of fit with the dis response cursor and and", "fnfbQPjwdqQ-00592-00397835-00398919": "also the mixed mechanism but they still involve androgens yes yes in in the one", "fnfbQPjwdqQ-00593-00398919-00399800": "mixture the three players antagonize the androgen receptor and you saw the", "fnfbQPjwdqQ-00594-00399800-00400385": "quality of dose response analysis which we conducted the regression models with", "fnfbQPjwdqQ-00595-00400385-00401166": "confidence belts etc and I'm not sure I'm getting your point but the", "fnfbQPjwdqQ-00596-00401166-00401646": "diagnostic criterion which we used to assess agreement with the prediction is", "fnfbQPjwdqQ-00597-00401646-00402260": "an overlap between the prediction belt around around the predicted curve and", "fnfbQPjwdqQ-00598-00402260-00402803": "the observed data if if these two overlap we conclude it's in", "fnfbQPjwdqQ-00599-00402803-00403336": "line with DOS Edition and that was the case with in almost all the all the", "fnfbQPjwdqQ-00600-00403336-00404906": "examples I've shown you accept this synergism other comments holder I'd like", "fnfbQPjwdqQ-00601-00404906-00405656": "to come back to the biomonitoring data I think we shouldn't over complicate the", "fnfbQPjwdqQ-00602-00405656-00406033": "interpretation of the biomonitoring data and shouldn't oversimplify the", "fnfbQPjwdqQ-00603-00406033-00406558": "interpretation of the external dos estimations for example by the chewing", "fnfbQPjwdqQ-00604-00406558-00406856": "experiments is on because you can chew and you can chew", "fnfbQPjwdqQ-00605-00406856-00407239": "you can take out the dough stick and it's the same of the biomonitoring", "fnfbQPjwdqQ-00606-00407239-00407867": "however picking up the lead from pole I think we've distillates we're in the", "fnfbQPjwdqQ-00607-00407867-00408467": "position that we very well know how consistent the exposure is within the", "fnfbQPjwdqQ-00608-00408467-00409042": "general population you have for at least six delights always positive", "fnfbQPjwdqQ-00609-00409042-00409469": "biomonitoring values you have positive detects of at least six delights in", "fnfbQPjwdqQ-00610-00409469-00410393": "urine and to make it clear detecting has nothing to do with risk or a hazard but", "fnfbQPjwdqQ-00611-00410393-00411118": "we can extrapolate the metabolite that was pretty reliable pretty reliable to", "fnfbQPjwdqQ-00612-00411118-00411931": "the dose taken up and there are other studies I think Russ Villa also can can", "fnfbQPjwdqQ-00613-00411931-00412475": "talk about it that we pretty much know that those who have been in the upper", "fnfbQPjwdqQ-00614-00412475-00412817": "quartiles pretty consistently in the upper", "fnfbQPjwdqQ-00615-00412817-00413327": "quartiles for for most of the steroids and for others they are not and yes we", "fnfbQPjwdqQ-00616-00413327-00413833": "can individual look at the the late exposure of each individual we've done", "fnfbQPjwdqQ-00617-00413833-00414298": "this in German if the children by a mental survey we can up the delayed", "fnfbQPjwdqQ-00618-00414298-00414835": "levels on individual basis so we can really sum up the dose of each", "fnfbQPjwdqQ-00619-00414835-00415348": "individual regarding the phthalates and looking at Ben's data plus other anti", "fnfbQPjwdqQ-00620-00415348-00415808": "hydrogen's long as you have time series you can do that", "fnfbQPjwdqQ-00621-00415808-00416319": "yeah but Paul isn't it the same with before the external dollars", "fnfbQPjwdqQ-00622-00416319-00416835": "extrapolations with chewing or not chewing taking the teeth in the mouth or", "fnfbQPjwdqQ-00623-00416835-00417315": "not measuring air concentrations and dust concentrations I couldn't be in the", "fnfbQPjwdqQ-00624-00417315-00417727": "room in the can't be in the room I can take it I think the the issue of the", "fnfbQPjwdqQ-00625-00417727-00418464": "external dose the external exposures if you're talking about where the exposure", "fnfbQPjwdqQ-00626-00418464-00418981": "occurring if the occurring in the home yes you have consistency because the", "fnfbQPjwdqQ-00627-00418981-00419425": "levels aren't going to change from day to day because you have you have all", "fnfbQPjwdqQ-00628-00419425-00419943": "these products that have phthalates you know so that that's fine under that", "fnfbQPjwdqQ-00629-00419943-00420540": "circumstance but if you're looking at the high-end exposures who knows it can", "fnfbQPjwdqQ-00630-00420540-00421138": "be for anything but things where there's a consistent day to day reasonable you", "fnfbQPjwdqQ-00631-00421138-00421609": "know consistency in levels which you probably have in most homes I see no", "fnfbQPjwdqQ-00632-00421609-00421944": "problem with it's just those high-end Peaks you're gonna you're gonna find", "fnfbQPjwdqQ-00633-00421944-00422554": "them that that that is not easy to predict no but I think we we have to", "fnfbQPjwdqQ-00634-00422554-00422994": "have a reality check here I think we also found that the exposure information", "fnfbQPjwdqQ-00635-00422994-00423481": "for phthalates is is as good as it gets it's sufficiently good to do this", "fnfbQPjwdqQ-00636-00423481-00424255": "exercise and that's fine we can you know that's good data from the US the", "fnfbQPjwdqQ-00637-00424255-00424930": "announced data and also good data from from Germany very extensive data and you", "fnfbQPjwdqQ-00638-00424930-00425556": "can construct 95 under 95th percentile as a criterion for high exposures that's", "fnfbQPjwdqQ-00639-00425556-00426403": "sufficient we have to be realistic it's you can dot the i's and cross the t's if", "fnfbQPjwdqQ-00640-00426403-00426888": "you like but I don't think it'll alter much was it general because there have", "fnfbQPjwdqQ-00641-00426888-00427419": "been smaller studies where they looked at people for what a week two weeks or", "fnfbQPjwdqQ-00642-00427419-00427810": "something like they looked at day to day and even within a day I mean there are", "fnfbQPjwdqQ-00643-00427810-00428452": "variations yeah I was gonna comment on that there are those studies or these", "fnfbQPjwdqQ-00644-00428452-00429050": "repeated measures yeah I guess there's a point where you just have to take a leap", "fnfbQPjwdqQ-00645-00429050-00429512": "our discussion to sow eggs there's no I don't have a problem with it when you", "fnfbQPjwdqQ-00646-00429512-00430025": "start burning throwing him pesticides you can't it's a totally different set", "fnfbQPjwdqQ-00647-00430025-00430628": "of circumstances and applications and source patterns when you say you can't", "fnfbQPjwdqQ-00648-00430628-00431180": "what can you not do it's gonna be a constant level because you have", "fnfbQPjwdqQ-00649-00431180-00431549": "application it's periodic and it's not every day of the week and you don't know", "fnfbQPjwdqQ-00650-00431549-00432077": "whether the person is getting a very high exposure on day X versus day Y it's", "fnfbQPjwdqQ-00651-00432077-00432563": "it's a difference in terms of source distribution and source release the", "fnfbQPjwdqQ-00652-00432563-00432968": "emissions from a power plant are consistent from day to day all right", "fnfbQPjwdqQ-00653-00432968-00433457": "that's because the source is constant the emissions of phthalates in home will", "fnfbQPjwdqQ-00654-00433457-00433862": "be fairly constant because you have some more sources every day the difference", "fnfbQPjwdqQ-00655-00433862-00434443": "between that and other kinds of sources will in fact depending on the", "fnfbQPjwdqQ-00656-00434443-00435127": "periodicity the intensity and the contact that you have different", "fnfbQPjwdqQ-00657-00435127-00435670": "variables yes but all this is true but again we need a reality check the", "fnfbQPjwdqQ-00658-00435670-00436409": "exposures or intakes of a large number of pesticides are regularly estimated on", "fnfbQPjwdqQ-00659-00436409-00436843": "a mandatory basis in Europe the information is there well I guess it", "fnfbQPjwdqQ-00660-00436843-00437267": "depends if if you're exposed from residues in food it may be fairly", "fnfbQPjwdqQ-00661-00437267-00437951": "consistent if it's the one you spray at home that's a little bit different which", "fnfbQPjwdqQ-00662-00437951-00438500": "is basically where the highest exposure ketoconazole i think is a used in for", "fnfbQPjwdqQ-00663-00438500-00438967": "human you know athlete's foot or something so that may be a little more", "fnfbQPjwdqQ-00664-00438967-00439580": "sporadic but but I think that the phthalate exposure is also sporadic", "fnfbQPjwdqQ-00665-00439580-00440030": "because in part from home exposure there's a use of personal care products", "fnfbQPjwdqQ-00666-00440030-00440417": "you know you use it in the morning then you may reapply something in the", "fnfbQPjwdqQ-00667-00440417-00440834": "afternoon the evening and then I think a lot also depends on the timing of the", "fnfbQPjwdqQ-00668-00440834-00441278": "urine sample I mean you you could have someone that you know uses a product at", "fnfbQPjwdqQ-00669-00441278-00441791": "6:00 a.m. take a urine sample at 8 and a 10 a.m. you're going to get very", "fnfbQPjwdqQ-00670-00441791-00442238": "different levels because of the short half-life so I think for phthalates -", "fnfbQPjwdqQ-00671-00442238-00442831": "there's a lot of intermittence exposures that are used in", "fnfbQPjwdqQ-00672-00442831-00443317": "personal care products semi-volatile were they mostly non-volatile they're", "fnfbQPjwdqQ-00673-00443317-00443929": "the same that's the butyl and the ethyl so they're like semi volatile but they", "fnfbQPjwdqQ-00674-00443929-00444499": "do you do absorb them through the skin so there there will be you know apart", "fnfbQPjwdqQ-00675-00444499-00444856": "from you know maybe your home or office environment where there's an indoor air", "fnfbQPjwdqQ-00676-00444856-00445306": "level you know as you apply these products as you eat different foods", "fnfbQPjwdqQ-00677-00445306-00445953": "throughout the day you're gonna be dosed at different well but again for those", "fnfbQPjwdqQ-00678-00445953-00446853": "ethyl and butyl it the exposures may be more episodic whereas for de HPD InP", "fnfbQPjwdqQ-00679-00446853-00447526": "maybe it is more a little more constant I mean it's I think the e HP and and", "fnfbQPjwdqQ-00680-00447526-00447937": "hoger has some data on this that presented at a meeting a few years ago", "fnfbQPjwdqQ-00681-00447937-00448585": "was primarily through foods right so that would also be you know episodic and", "fnfbQPjwdqQ-00682-00448585-00449056": "then a lot depends too on the you know the spot urine samples when they're", "fnfbQPjwdqQ-00683-00449056-00449692": "taken relative so that's probably why you're seeing you know the variability", "fnfbQPjwdqQ-00684-00449692-00450222": "isn't as much as what someone's exposed to as much also as when that urine", "fnfbQPjwdqQ-00685-00450222-00450691": "samples taken relative to when that exposure occurred and you know you're", "fnfbQPjwdqQ-00686-00450691-00451068": "detecting these in whatever ninety ninety five percent of the population I", "fnfbQPjwdqQ-00687-00451068-00451528": "mean my feeling is and you know that few percent that you may not detecting it it", "fnfbQPjwdqQ-00688-00451528-00452010": "may be that you know they're using these products or eating something but their", "fnfbQPjwdqQ-00689-00452010-00452568": "exposure is far enough remote from the urine sample that you're not detecting", "fnfbQPjwdqQ-00690-00452568-00453420": "it meaning that there's widespread we're gonna need some exposure scenarios or", "fnfbQPjwdqQ-00691-00453420-00454072": "exposure characteristics to deal with what andreas we're doing doing with the", "fnfbQPjwdqQ-00692-00454072-00454606": "50th percentile the 90th percentile we're gonna be dealing with a the key", "fnfbQPjwdqQ-00693-00454606-00455170": "will be you know how one construction constructed these profiles to get some", "fnfbQPjwdqQ-00694-00455170-00455559": "level of underst of how it relates at some point in time", "fnfbQPjwdqQ-00695-00455559-00456267": "to biomonitoring because without that and all this stuff is could be", "fnfbQPjwdqQ-00696-00456267-00456727": "stochastic well there is there is some data I mean there's there's data that", "fnfbQPjwdqQ-00697-00456727-00457156": "actually people have taken urine samples multiple times throughout a day relative", "fnfbQPjwdqQ-00698-00457156-00457576": "to a point exposure and then there's data on people you know", "fnfbQPjwdqQ-00699-00457576-00458113": "repeated-measures you know you may have ten or fifteen on the same person over a", "fnfbQPjwdqQ-00700-00458113-00458859": "month or several months so those can be used as our benchmarks yes okay well it", "fnfbQPjwdqQ-00701-00458859-00459363": "is to answer your question it isn't very important if you if you pursue the", "fnfbQPjwdqQ-00702-00459363-00459873": "hazard index approach to get the dose metrics right it burnt tissue levels", "fnfbQPjwdqQ-00703-00459873-00460600": "would would be of no use for that at this present state because there's only", "fnfbQPjwdqQ-00704-00460600-00461022": "one demand with the hazard index approach the dose metric off the", "fnfbQPjwdqQ-00705-00461022-00461680": "numerator has to be the same as the one of the denominator which is intake the", "fnfbQPjwdqQ-00706-00461680-00462321": "numerators intake so however if in the future there's more information", "fnfbQPjwdqQ-00707-00462321-00463107": "available about how human tissue levels compare with tissue levels for example", "fnfbQPjwdqQ-00708-00463107-00463600": "in the rat that associated with the effects then you could do a better read", "fnfbQPjwdqQ-00709-00463600-00464157": "across but at the moment this kind of data is not available but this is not", "fnfbQPjwdqQ-00710-00464157-00464713": "only relevant for interpreting biomonitoring data what you said that's", "fnfbQPjwdqQ-00711-00464713-00465754": "relevant for interpreting all data oh yeah I'm happy to concede that yet yes I", "fnfbQPjwdqQ-00712-00465754-00466113": "have a quick question which was kind of in a different direction", "fnfbQPjwdqQ-00713-00466113-00466563": "you know what you've presented I think you've presented it clearly but it's", "fnfbQPjwdqQ-00714-00466563-00467196": "complex and so you're looking at compounds that may act through common", "fnfbQPjwdqQ-00715-00467196-00468142": "adverse outcome mechanisms but then we know that there are chemicals that may", "fnfbQPjwdqQ-00716-00468142-00468497": "alter the metabolism of some of these come on", "fnfbQPjwdqQ-00717-00468497-00468967": "so it could become even more complex so for instance that there's another", "fnfbQPjwdqQ-00718-00468967-00469483": "chemical that may increase or decrease the rate of metabolism and therefore", "fnfbQPjwdqQ-00719-00469483-00470233": "clearance of phthalates is is that something that can be considered in", "fnfbQPjwdqQ-00720-00470233-00470845": "these I mean it would be I think another step forward because you know you're", "fnfbQPjwdqQ-00721-00470845-00471385": "you're looking at common adverse outcome or mechanisms this is a very important", "fnfbQPjwdqQ-00722-00471385-00472159": "question and and the this is where the limit of of this predictive approach to", "fnfbQPjwdqQ-00723-00472159-00472570": "mix the toxicology well that's where the limits are of this approach which we", "fnfbQPjwdqQ-00724-00472570-00473278": "pursue because what you're talking about is a situation where in isolation", "fnfbQPjwdqQ-00725-00473278-00473728": "chemical a doesn't do anything but say combined with an anti-androgen and", "fnfbQPjwdqQ-00726-00473728-00474264": "phthalates would exacerbate the effects of the phthalates or the other engine", "fnfbQPjwdqQ-00727-00474264-00474817": "with mixture effect prediction and assessment this only works for come for", "fnfbQPjwdqQ-00728-00474817-00475312": "combinations that all produce the effect you're just interested in and then you", "fnfbQPjwdqQ-00729-00475312-00475951": "can model so what you've described is a very important point but at the moment", "fnfbQPjwdqQ-00730-00475951-00476701": "essentially unpredictable quantitatively you may arrive at qualitative", "fnfbQPjwdqQ-00731-00476701-00477112": "predictions you can say right if we combine a solid with this and that", "fnfbQPjwdqQ-00732-00477112-00477706": "chemical qualitatively we would expect the effect to get worse or better but", "fnfbQPjwdqQ-00733-00477706-00478288": "one you cannot easily predict at this stage to what degree the effect would", "fnfbQPjwdqQ-00734-00478288-00478870": "get worse or better this is done very frequently with drug interactions you", "fnfbQPjwdqQ-00735-00478870-00479329": "know someone's on drug a and you say well don't take drug B because its", "fnfbQPjwdqQ-00736-00479329-00479789": "metabolism is impaired and the dose you're actually taking is not ten", "fnfbQPjwdqQ-00737-00479789-00480285": "milligrams that your body will see but you know 100 milligrams because drug a", "fnfbQPjwdqQ-00738-00480285-00481108": "is impairing its metabolism so our goal is to come up with some numbers that", "fnfbQPjwdqQ-00739-00481108-00481691": "determine whether or not there's gonna be a ban on the use of", "fnfbQPjwdqQ-00740-00481691-00482710": "this products in in toy you know in toys and in other kids products so how do we", "fnfbQPjwdqQ-00741-00482710-00483535": "approach this going toward what kind of a degree of uncertainty or certainty", "fnfbQPjwdqQ-00742-00483535-00484112": "we're gonna allow on both sides of the questions to to at least come up with", "fnfbQPjwdqQ-00743-00484112-00484634": "some reasonable estimates because if we don't set some reasonable targets we can", "fnfbQPjwdqQ-00744-00484634-00485189": "spend our time arguing about you know whether it's you know how much", "fnfbQPjwdqQ-00745-00485189-00485672": "uncertainty were we're gonna allow in any one measurement and I'm fearful that", "fnfbQPjwdqQ-00746-00485672-00486154": "that's gonna cause us a lot of problems well I think that leads us right into", "fnfbQPjwdqQ-00747-00486154-00486760": "the next thing we wanted to discuss and I think at this point maybe we should", "fnfbQPjwdqQ-00748-00486760-00487639": "take a break come back at and 15 and pursue you know what is an acceptable", "fnfbQPjwdqQ-00749-00487639-00488258": "risk that the point that Byrne brought up and acceptable risk with what", "fnfbQPjwdqQ-00750-00488258-00488893": "endpoints those are critical issues we need to really discuss and and come to", "fnfbQPjwdqQ-00751-00488893-00490571": "some kind of consensus okay I like the idea of don't have anyone everyone here", "fnfbQPjwdqQ-00752-00490571-00491300": "at the moment but I think we should get started again and now I'd like to start", "fnfbQPjwdqQ-00753-00491300-00491872": "a discussion about some of the issues that we're gonna have to come to", "fnfbQPjwdqQ-00754-00491872-00492677": "consensus on and I think the first one we deal with is and it's going to be one", "fnfbQPjwdqQ-00755-00492677-00493445": "of our charges is what is acceptable risk and in order to really talk about", "fnfbQPjwdqQ-00756-00493445-00493955": "that we're going to talk about with respect to which end points so I'm gonna", "fnfbQPjwdqQ-00757-00493955-00494418": "have burned lead this discussion", "fnfbQPjwdqQ-00758-00494553-00495835": "burne would you take take the mic yes I got your cue well I'm not sure that it", "fnfbQPjwdqQ-00759-00495835-00496471": "will take us a long time to initially reach agreement on what are the end", "fnfbQPjwdqQ-00760-00496471-00497337": "points of talks pelagic response we want to consider as the prime end points and", "fnfbQPjwdqQ-00761-00497337-00497833": "we've seen them outlined we've been talking about them in that context", "fnfbQPjwdqQ-00762-00497833-00498543": "already but I think we we need to have a discussion of we're going to cast the", "fnfbQPjwdqQ-00763-00498543-00499051": "net fairly widely and moved by brute force through these or are we going to", "fnfbQPjwdqQ-00764-00499051-00499675": "cast the net fairly narrowly at least initially so that we would pick ones", "fnfbQPjwdqQ-00765-00499675-00500493": "that we would most likely be able to reach agreement on for acceptable risk", "fnfbQPjwdqQ-00766-00500493-00501010": "because we have the data to be able to consider that and then if there are", "fnfbQPjwdqQ-00767-00501010-00501301": "endpoints beyond that where it's more difficult we can always come back and", "fnfbQPjwdqQ-00768-00501301-00501831": "pick those up later my suggestion would be that we not try the brute force", "fnfbQPjwdqQ-00769-00501831-00502363": "approach and cast the net widely and look at all kinds of end points I would", "fnfbQPjwdqQ-00770-00502363-00503053": "say that we should get our teeth into a better defined and a better agreed upon", "fnfbQPjwdqQ-00771-00503053-00503845": "one or two or three and didn't see if we can work out an understanding of what", "fnfbQPjwdqQ-00772-00503845-00504274": "acceptable risk would be for one or two where we have a lot of information and", "fnfbQPjwdqQ-00773-00504274-00504693": "it's repeatable observations we're spending our time on what everybody", "fnfbQPjwdqQ-00774-00504693-00505393": "would agree to is the important endpoint for considering risk so before we we", "fnfbQPjwdqQ-00775-00505393-00505801": "talk about how we would reach agreement on what that risk or that acceptable", "fnfbQPjwdqQ-00776-00505801-00506247": "risk is perhaps we can have a discussion of what are the endpoints that we should", "fnfbQPjwdqQ-00777-00506247-00507279": "really consider and Mike you you had", "fnfbQPjwdqQ-00778-00507373-00507893": "I don't know if it's on the slide I don't think it is but if we're talking", "fnfbQPjwdqQ-00779-00507893-00508427": "about the developmental effects in the male's I mean it's it's the range is", "fnfbQPjwdqQ-00780-00508427-00509183": "from it's not here but the range is from you know testosterone starts with", "fnfbQPjwdqQ-00781-00509183-00510376": "testosterone production and then from there on up to testosterone production", "fnfbQPjwdqQ-00782-00510376-00511000": "anogenital distance nipple retention", "fnfbQPjwdqQ-00783-00511243-00511934": "cryptorchidism and high post Beatty is I think is the range of effects that you", "fnfbQPjwdqQ-00784-00511934-00512726": "see you could add in a prostate weight or something there's a couple other", "fnfbQPjwdqQ-00785-00512726-00513353": "things you could include but those are the highlights and I guess the question", "fnfbQPjwdqQ-00786-00513353-00514181": "is do you want to I don't know that you can have the the whole range of effects", "fnfbQPjwdqQ-00787-00514181-00514817": "on all the relevant phalates and I don't know do you it's a matter of I think in", "fnfbQPjwdqQ-00788-00514817-00515557": "the NRC report was it did you was a testosterone production or lethality or", "fnfbQPjwdqQ-00789-00515557-00516314": "public allottee I can't remember what the end point that you focused on just", "fnfbQPjwdqQ-00790-00516314-00517021": "aa stirone yeah yeah I guess that's the other extreme but testosterone levels", "fnfbQPjwdqQ-00791-00517021-00517814": "and that's fine usually for that you would pick a you know a 10% drop or you", "fnfbQPjwdqQ-00792-00517814-00518319": "know you pick some number that you consider to be adverse I mean that's a", "fnfbQPjwdqQ-00793-00518319-00519239": "toxicologist kind of decision but you know do you want to pick one end point", "fnfbQPjwdqQ-00794-00519239-00519809": "yeah I mean that you can do that apply that to all the phalates I guess the", "fnfbQPjwdqQ-00795-00519809-00520532": "other option is depending on with the data that are available you might use", "fnfbQPjwdqQ-00796-00520532-00521161": "some combination of the the endpoints", "fnfbQPjwdqQ-00797-00521161-00521951": "anti-androgen again points but that's I think that those are the options on the", "fnfbQPjwdqQ-00798-00521951-00522946": "table for the male developmental effects you know which of these endpoints or", "fnfbQPjwdqQ-00799-00522946-00523595": "combination of do you do you want to use or are they at this point maybe still", "fnfbQPjwdqQ-00800-00523595-00524278": "all on the table maybe before we we try to take the male developmental effects", "fnfbQPjwdqQ-00801-00524278-00524955": "to a final decision let's look a little more broadly what about the female", "fnfbQPjwdqQ-00802-00524955-00525905": "developmental effects I I don't know offhand if anybody wants to jump jump in", "fnfbQPjwdqQ-00803-00525905-00526592": "i mean the there are a variety of reproductive and developmental effects", "fnfbQPjwdqQ-00804-00526592-00527280": "and for example if you expose earlier during gestation there are effects in", "fnfbQPjwdqQ-00805-00527280-00528305": "both males and females skeletal variations and visceral or the organ", "fnfbQPjwdqQ-00806-00528305-00529176": "malformations and so on then later in gestation is where you see the in tight", "fnfbQPjwdqQ-00807-00529176-00530072": "androgenic effects and I'm not sure at birth what you see in the females I you", "fnfbQPjwdqQ-00808-00530072-00530761": "know there's at least one report where there are behavioral effects later on", "fnfbQPjwdqQ-00809-00530869-00531569": "but that you know there it's it's sort of a a mix of things but you know the", "fnfbQPjwdqQ-00810-00531569-00532251": "male pups are the ones that are affected the most and you know that's probably I", "fnfbQPjwdqQ-00811-00532251-00532865": "think a good starting point is to say for any kind of developmental", "fnfbQPjwdqQ-00812-00532865-00533613": "reproductive effects the anti-androgen isset II is is going to be the most", "fnfbQPjwdqQ-00813-00533613-00534101": "potent endpoint for the active phalates", "fnfbQPjwdqQ-00814-00534117-00535117": "now if you want to expand that to all the phthalates you would have to look at", "fnfbQPjwdqQ-00815-00535117-00535982": "something else like any developmental effect or me perhaps the developmental", "fnfbQPjwdqQ-00816-00535982-00536921": "effects that occur earlier in just earlier in gestation we're fortunate in", "fnfbQPjwdqQ-00817-00536921-00537671": "this if you want to consider this a good fortune that the most sensitive affect", "fnfbQPjwdqQ-00818-00537671-00538090": "is also a serious effect yes so we're not looking at a trivial effect right oh", "fnfbQPjwdqQ-00819-00538090-00538907": "it's a severe effect yes yeah I don't know the literature all that well in", "fnfbQPjwdqQ-00820-00538907-00539555": "terms of embryonic exposures to to phthalates but I suspect there's not a", "fnfbQPjwdqQ-00821-00539555-00540221": "whole lot there do you know burn I think that's right and certainly most of the", "fnfbQPjwdqQ-00822-00540221-00541038": "attention has been what Michael exposures amount of studies I mean that", "fnfbQPjwdqQ-00823-00541038-00541826": "was the problem early on the studies I mean I can't remember exactly the", "fnfbQPjwdqQ-00824-00541826-00542613": "details but they occurred during organogenesis and so you didn't see", "fnfbQPjwdqQ-00825-00542613-00543192": "these anti-angiogenic effects you did see malformations things and the", "fnfbQPjwdqQ-00826-00543192-00544323": "skeletal things heart defects in even kidney defects and a lot of those are", "fnfbQPjwdqQ-00827-00544323-00545067": "covered in the seee CRH are reports the it was all more recently that people", "fnfbQPjwdqQ-00828-00545067-00545730": "started exposing later in gestation during the the critical period for", "fnfbQPjwdqQ-00829-00545730-00546767": "sexual differentiation so I think there's a there's a reasonable amount of", "fnfbQPjwdqQ-00830-00546767-00547046": "data on both", "fnfbQPjwdqQ-00831-00547184-00548216": "oh and I think much higher dose maybe yeah", "fnfbQPjwdqQ-00832-00548216-00548813": "yeah yeah yeah I mean dose response is always yeah I'm not sure how good that", "fnfbQPjwdqQ-00833-00548813-00549452": "is but even in the older studies there was usually an effort to try to find a", "fnfbQPjwdqQ-00834-00549452-00549920": "no effect level right right so that's one reference point that we would be", "fnfbQPjwdqQ-00835-00549920-00550388": "working from I mean there weren't a lot of a lot of doses but yeah I mean there", "fnfbQPjwdqQ-00836-00550388-00551078": "were generally Noelle's very well so we've talked about the male", "fnfbQPjwdqQ-00837-00551078-00551450": "developmental effects and to some extent the lesser extent female developmental", "fnfbQPjwdqQ-00838-00551450-00551744": "effects those are both categories of responses", "fnfbQPjwdqQ-00839-00551744-00552584": "that we might want to consider for an acceptable risk discussion what about", "fnfbQPjwdqQ-00840-00552584-00553409": "exposure to the young animals or adolescents as opposed to adults and the", "fnfbQPjwdqQ-00841-00553409-00554242": "conceptus is there a group of effects that are observed primarily when", "fnfbQPjwdqQ-00842-00554242-00554866": "adolescents are exposed well not that I know I think they're just less severe", "fnfbQPjwdqQ-00843-00554866-00555734": "you know similar if antigenicity there's similar kinds of effects they just that", "fnfbQPjwdqQ-00844-00555734-00556379": "the juveniles are not as sensitive is the fetus and of course the adult even", "fnfbQPjwdqQ-00845-00556379-00557414": "in the adults at high enough doses it'll damage the testes but there it's they're", "fnfbQPjwdqQ-00846-00557414-00558356": "just less sensitive oh if we're going to be looking at products that children are", "fnfbQPjwdqQ-00847-00558356-00558965": "using after they're born and you know and while they're growing up a young age", "fnfbQPjwdqQ-00848-00558965-00559616": "what what is gonna be the endpoint that we're gonna target for these estimates", "fnfbQPjwdqQ-00849-00559616-00560117": "of risk I mean you know you say well you know sort of glibly you know what goes", "fnfbQPjwdqQ-00850-00560117-00560759": "down yeah but you know that's we're the target of our investigation is", "fnfbQPjwdqQ-00851-00560759-00561647": "supposed to go even though we are to include the pregnant mother I don't", "fnfbQPjwdqQ-00852-00561647-00562037": "understand we have to be a little bit more firm than say then well you know", "fnfbQPjwdqQ-00853-00562037-00562640": "well you're right I think you have to consider that their young children and", "fnfbQPjwdqQ-00854-00562640-00563198": "their more may be less susceptible than fetus but they're more susceptible than", "fnfbQPjwdqQ-00855-00563198-00563762": "adults how do you make that point with some clarity can we make that", "fnfbQPjwdqQ-00856-00563762-00564380": "quantitative yeah and I don't know because I think the data are limited it", "fnfbQPjwdqQ-00857-00564380-00565072": "may be you know maybe it's something you apply safety factor to I don't know", "fnfbQPjwdqQ-00858-00565094-00565828": "there's a recent paper by Richard chops group they looked at the effect of", "fnfbQPjwdqQ-00859-00565828-00566501": "suppression of Antron synthesis in the what's I called male programming window", "fnfbQPjwdqQ-00860-00566501-00567089": "but also then were able to lucid eight that for proper growth and development", "fnfbQPjwdqQ-00861-00567089-00567821": "of external genitalia in these words under an action after birth is necessary", "fnfbQPjwdqQ-00862-00567821-00568592": "as well so if you compromise under an action after birth it definitely doesn't", "fnfbQPjwdqQ-00863-00568592-00569090": "get better as a does a nice paper published in International Journal of", "fnfbQPjwdqQ-00864-00569090-00569597": "oncology the same volume well yeah I noticed there so actually I guess there", "fnfbQPjwdqQ-00865-00569597-00569882": "are they I don't know if they're reviews but there's a lot of stuff in that", "fnfbQPjwdqQ-00866-00569882-00570911": "particular issue yeah so maybe that would help us interpret this issue is is", "fnfbQPjwdqQ-00867-00570911-00571582": "my sense correct Mike that we're more data rich when we're talking about", "fnfbQPjwdqQ-00868-00571582-00572069": "developmental reproductive endpoints definitely then we were", "fnfbQPjwdqQ-00869-00572069-00572580": "talking about postnatal right yeah so I you know this our strategy might be then", "fnfbQPjwdqQ-00870-00572580-00573317": "to use you know the more data rich endpoints and then hopefully at some", "fnfbQPjwdqQ-00871-00573317-00573788": "point be able to do some extrapolations to two children and add", "fnfbQPjwdqQ-00872-00573788-00574415": "and adults where the sensitivity is D we know it's decreased well I think this is", "fnfbQPjwdqQ-00873-00574415-00574892": "the time for us to be complete and not to have to revisit these things later on", "fnfbQPjwdqQ-00874-00574892-00575351": "when we think we've done the job only to find out that we have to now go back and", "fnfbQPjwdqQ-00875-00575351-00575705": "look at something else so if we can eliminate some things now Paul I think", "fnfbQPjwdqQ-00876-00575705-00576224": "your question is a good reminder yeah because if you look at the next category", "fnfbQPjwdqQ-00877-00576224-00576584": "now in this progression from developmental effects to the adolescent", "fnfbQPjwdqQ-00878-00576584-00577016": "effects now to the adult effects I think the question I would have of what we've", "fnfbQPjwdqQ-00879-00577016-00577769": "seen from the adult exposure data would be the question for example is there a", "fnfbQPjwdqQ-00880-00577769-00578538": "risk of cancer when neonates are exposed and you get liver liver cancer as adults", "fnfbQPjwdqQ-00881-00578538-00579317": "they're not going to get liver cancer as as young children or infants but are", "fnfbQPjwdqQ-00882-00579317-00579809": "there changes in the liver that predisposed them to liver cancer later", "fnfbQPjwdqQ-00883-00579809-00580380": "on yeah I don't think anyone knows no I don't think there's any information on", "fnfbQPjwdqQ-00884-00580380-00581130": "that but again it's questionable whether the mode of action is relevant to humans", "fnfbQPjwdqQ-00885-00581130-00581355": "that's correct so there are there's a lot of", "fnfbQPjwdqQ-00886-00581355-00582040": "uncertainty there that keeps this as a low priority concern yeah I think so but", "fnfbQPjwdqQ-00887-00582040-00582974": "the question that that I'll come back to is if I'm going to consider exposure as", "fnfbQPjwdqQ-00888-00582974-00584136": "an issue or you know the young child growing up with these toys and personal", "fnfbQPjwdqQ-00889-00584136-00584751": "care products we're gonna need something to link to I mean obviously you know", "fnfbQPjwdqQ-00890-00584751-00585507": "what you said then if we can get some information that helps us with the male", "fnfbQPjwdqQ-00891-00585507-00585998": "programming that would be important because I think we that that alone is", "fnfbQPjwdqQ-00892-00585998-00586436": "going to have to be the one single thing that's going to make the difference as", "fnfbQPjwdqQ-00893-00586436-00587016": "to how much uncertainty we start with because otherwise", "fnfbQPjwdqQ-00894-00587016-00587830": "it's gonna be rather difficult to make quantitative assessments one of the", "fnfbQPjwdqQ-00895-00587830-00588192": "things that fellow Mike and I were talking about at the break", "fnfbQPjwdqQ-00896-00588192-00588778": "he was our need to be very articulate in identifying the assumptions that we make", "fnfbQPjwdqQ-00897-00588778-00589182": "right because that I think will be as important as anything else that we would", "fnfbQPjwdqQ-00898-00589182-00589539": "have in a final document is what assumptions did we make as we try to", "fnfbQPjwdqQ-00899-00589539-00590094": "determine what the risks were and if we're going to come down with", "fnfbQPjwdqQ-00900-00590094-00590686": "recommendations on restricting uses it certainly has to be a there has to be a", "fnfbQPjwdqQ-00901-00590686-00591001": "clear identification of the assumptions that we made in arriving at the numbers", "fnfbQPjwdqQ-00902-00591001-00591693": "that we arrive at to make that conclusion are there any other", "fnfbQPjwdqQ-00903-00591693-00592317": "considerations from the adult exposures that direct us toward a potential risk", "fnfbQPjwdqQ-00904-00592317-00593634": "consideration for children well from the I mean chronic studies target the liver", "fnfbQPjwdqQ-00905-00593634-00594126": "and kidney among other things right it's not just tumors but other right a", "fnfbQPjwdqQ-00906-00594126-00595609": "chronic toxicity there there are also we should consider I think reproductive", "fnfbQPjwdqQ-00907-00595609-00596669": "effects in adults and just as an example the the slide that's up here right now", "fnfbQPjwdqQ-00908-00596741-00598059": "it sums up what the CER HR has said about this set of chemicals or I guess", "fnfbQPjwdqQ-00909-00598059-00598578": "all the chemicals that they reviewed I mean it covers developmental and", "fnfbQPjwdqQ-00910-00598578-00599228": "reproductive but there are reproductive effects too in you know to Jen studies", "fnfbQPjwdqQ-00911-00599228-00599642": "it's not all developmental", "fnfbQPjwdqQ-00912-00600077-00601301": "for example well let's see I could find a high concern I guess that the most", "fnfbQPjwdqQ-00913-00601301-00602525": "serious ones are developmental and the reproductive effects seen in adults are", "fnfbQPjwdqQ-00914-00602525-00603589": "the same mechanism for males yes fimA females I'm not so sure", "fnfbQPjwdqQ-00915-00604799-00605294": "yes yeah I I think some of the questions you're answering I think Paul Foster", "fnfbQPjwdqQ-00916-00605294-00605765": "would really be you know the one that would be able to to answer some of these", "fnfbQPjwdqQ-00917-00605765-00606199": "because I know we're thinking too about you know who to to bring it here in July", "fnfbQPjwdqQ-00918-00606199-00606930": "no specific questions about how the mechanism may differ in Euro versus", "fnfbQPjwdqQ-00919-00606930-00607430": "adult I know some of the data you know I'm not as familiar with the laboratory", "fnfbQPjwdqQ-00920-00607430-00608211": "animal data so I know there are differences and I think Paul foster", "fnfbQPjwdqQ-00921-00608211-00608846": "would really be able to help us through that definitely yeah he'd be the best", "fnfbQPjwdqQ-00922-00608846-00609623": "person to answer a lot of these questions okay that's a good thing to", "fnfbQPjwdqQ-00923-00609623-00609938": "put on the side mooing pick that up when we have the discussion yesterday about", "fnfbQPjwdqQ-00924-00609938-00610659": "the questions and the people thanks for us yeah yeah he I think he", "fnfbQPjwdqQ-00925-00610659-00611240": "would have be helpful to confirm our suspicions that the critical effects are", "fnfbQPjwdqQ-00926-00611240-00612134": "reproductive and the critical life stage in utero fetal exposures", "fnfbQPjwdqQ-00927-00612176-00612813": "he will also like Russ said be able to tell us something about other concerns", "fnfbQPjwdqQ-00928-00612813-00613526": "and I'm wondering bringing in someone we need probably someone who will dispel", "fnfbQPjwdqQ-00929-00613526-00614351": "our concerns or the niggling doubts we have about carcinogenicity we I think", "fnfbQPjwdqQ-00930-00614351-00615248": "all feel that this is off of limited relevance but maybe we should have this", "fnfbQPjwdqQ-00931-00615248-00615915": "confirmed by an expert confirmed are otherwise I'm thinking of who would be", "fnfbQPjwdqQ-00932-00615915-00616538": "suitable Geoffrey Peters oh he would be fantastic if we can coax coax him down", "fnfbQPjwdqQ-00933-00616538-00617136": "here I think he'd be willing that for a day", "fnfbQPjwdqQ-00934-00617136-00618063": "I missed who you said Geoffrey Peters is that Penn State he was on the last", "fnfbQPjwdqQ-00935-00618063-00619095": "chap and he's an expert in the PPAR receptors hey that's another good thing", "fnfbQPjwdqQ-00936-00619095-00619887": "Phil to add to that list yeah because they're you know just so many questions", "fnfbQPjwdqQ-00937-00619887-00620877": "that come up you you know the developmental effects he jeffrey peters", "fnfbQPjwdqQ-00938-00620877-00621536": "did have had a paper where in the PPA our alpha know mice they looked at", "fnfbQPjwdqQ-00939-00621536-00622092": "treated on with de HP and there were developmental effects even without the", "fnfbQPjwdqQ-00940-00622092-00622758": "PPA our alpha so but these were the garden-variety developmental they", "fnfbQPjwdqQ-00941-00622758-00623583": "weren't the late gestation the anti androgenic ones so you know we you'll", "fnfbQPjwdqQ-00942-00623583-00624263": "always wonder just all these questions keep popping up and yeah he's the heat", "fnfbQPjwdqQ-00943-00624263-00624891": "would be able to answer all of those is that because they didn't look well at", "fnfbQPjwdqQ-00944-00624891-00625302": "that time exposures leighton right at the time they didn't didn't look at", "fnfbQPjwdqQ-00945-00625302-00625839": "exposures they didn't look although i mean they didn't do the experiment but", "fnfbQPjwdqQ-00946-00625839-00626819": "the structure-activity relationships are such that they don't correspond to the", "fnfbQPjwdqQ-00947-00626819-00627524": "induction of that pathway so these are all i mean there are a lot of nuances", "fnfbQPjwdqQ-00948-00627524-00628020": "but even if they're it's not uncommon in these developmental talk studies in the", "fnfbQPjwdqQ-00949-00628020-00628398": "standard designed to see decreased fetal body weight and even if that wasn't", "fnfbQPjwdqQ-00950-00628398-00628865": "mediated by an into androgenic mechanism it's still important oh absolutely it in", "fnfbQPjwdqQ-00951-00628865-00629610": "there are plenty of those effects yeah okay so we've talked about the male and", "fnfbQPjwdqQ-00952-00629610-00629913": "female developmental effects in the adolescents and the adults and we have", "fnfbQPjwdqQ-00953-00629913-00630603": "questions but perhaps we have looked at the horizon enough in in this regard to", "fnfbQPjwdqQ-00954-00630603-00631094": "know that we have an order of priority in terms of the knee", "fnfbQPjwdqQ-00955-00631094-00631563": "for the response and therefore the target organ and it happens to correlate", "fnfbQPjwdqQ-00956-00631563-00632132": "also with sensitivity one question to come back to the male developmental", "fnfbQPjwdqQ-00957-00632132-00632778": "effects since the the effects of concern are mediated through this hormonal", "fnfbQPjwdqQ-00958-00632778-00633236": "effect is it enough for us to look at the hormonal effect at the hormone", "fnfbQPjwdqQ-00959-00633236-00633761": "changes and say that everything else biologically is downstream from this so", "fnfbQPjwdqQ-00960-00633761-00634413": "we don't have to look at each one of these end points under the under the", "fnfbQPjwdqQ-00961-00634413-00634928": "testosterone effect individually is it sufficient for us just to look at well", "fnfbQPjwdqQ-00962-00634928-00635376": "you mentioned a 10% decrease it could be done that way or there could be other", "fnfbQPjwdqQ-00963-00635376-00636059": "ways to say here's the threshold for it effect on anti-angiogenic effects I", "fnfbQPjwdqQ-00964-00636059-00636521": "would welcome your thoughts on that because that really gets at the except", "fnfbQPjwdqQ-00965-00636521-00636863": "how we're gonna do acceptable risk what Gregg what are we going to assess", "fnfbQPjwdqQ-00966-00636863-00637419": "dosterone production or yeah AG is that it's a little harder you know with the", "fnfbQPjwdqQ-00967-00637419-00637961": "problem with testosterone is what's the level that is is adverse and I don't", "fnfbQPjwdqQ-00968-00637961-00638715": "know I said 10% as a hypothetical I have no idea what Witter should be but that's", "fnfbQPjwdqQ-00969-00638715-00639215": "a judgment that that's probably very difficult to judge but but what is clear", "fnfbQPjwdqQ-00970-00639215-00639749": "from the data that are published is that for phthalates the suppression of", "fnfbQPjwdqQ-00971-00639749-00640192": "testosterone fetal testosterone synthesis is the most sensitive endpoint", "fnfbQPjwdqQ-00972-00640192-00640680": "so if you base everything on that you protect against a lot of the other", "fnfbQPjwdqQ-00973-00640680-00641246": "effects but again we can ask Paul foster for confirmation there but I think as", "fnfbQPjwdqQ-00974-00641246-00641715": "far as I know the literature and judge it that's the case all right", "fnfbQPjwdqQ-00975-00641715-00642344": "for all other chemicals the most sensitive one is nipple retention and", "fnfbQPjwdqQ-00976-00642344-00642851": "with solids you're getting pretty close there too", "fnfbQPjwdqQ-00977-00643059-00643636": "so if you regard nipple retention in the rat model is indicative of disturbance", "fnfbQPjwdqQ-00978-00643636-00644077": "of and reduction in fetal life now there's an argument among some", "fnfbQPjwdqQ-00979-00644077-00644784": "toxicologist to helpfully point out that this effect is not of relevance to the", "fnfbQPjwdqQ-00980-00644784-00645546": "human but that's an argument to be had I mean that's that's the question here", "fnfbQPjwdqQ-00981-00645546-00646296": "just where do you draw the line yeah if you accept that we can't", "fnfbQPjwdqQ-00982-00646296-00646756": "I mean rats are different from humans thankfully in many ways so we are", "fnfbQPjwdqQ-00983-00646756-00647329": "different from them if you now take the stance that we're dealing with a model", "fnfbQPjwdqQ-00984-00647329-00647701": "anyway and this is a model for disturbance of and reduction in fetal", "fnfbQPjwdqQ-00985-00647701-00648319": "life I think one can get around this problem and the rat that is indicative", "fnfbQPjwdqQ-00986-00648319-00649069": "of disturbance let's let's use that and extrapolate to the human although this", "fnfbQPjwdqQ-00987-00649069-00649753": "plays out in a different way in the human female self it will help me to see", "fnfbQPjwdqQ-00988-00649753-00650479": "the dose responses together like this level of testosterone reduction causes", "fnfbQPjwdqQ-00989-00650479-00651396": "this level of nipple retention and so on that might help me sort it out but but", "fnfbQPjwdqQ-00990-00651396-00651871": "just to conclude I think what you're also driving at this other issue there", "fnfbQPjwdqQ-00991-00651871-00652507": "is you have with a lights a certain effect spectrum typical off of", "fnfbQPjwdqQ-00992-00652507-00653109": "disruption of interaction and that differs in some respects with the effect", "fnfbQPjwdqQ-00993-00653109-00653617": "spectrum which we you get from under and receptor antagonists they are distinct", "fnfbQPjwdqQ-00994-00653617-00654123": "in certain for example flu tomato and of inclusively and will not lead to", "fnfbQPjwdqQ-00995-00654123-00654646": "reductions in testosterone synthesis but there's a there's a commonality there's", "fnfbQPjwdqQ-00996-00654646-00655180": "an overlap of the effect seen with the lights in the rat and seen with under", "fnfbQPjwdqQ-00997-00655180-00655794": "and receptor antagonist so one could say we could go for the most sensitive", "fnfbQPjwdqQ-00998-00655794-00656254": "common effect of all these chemicals which I guess would be nipple returned", "fnfbQPjwdqQ-00999-00656254-00656794": "the alternative would be to sign we've played this through in the paper which I", "fnfbQPjwdqQ-01000-00656794-00657370": "showed you this morning we've said right we go for for the most sensitive end", "fnfbQPjwdqQ-01001-00657370-00658132": "point regardless we weren't looking for common effects or an overlap but that's", "fnfbQPjwdqQ-01002-00658132-00658749": "open for debate really my feeling is that this is a", "fnfbQPjwdqQ-01003-00658749-00659212": "considering all the other uncertainties we have to deal with that's the least of", "fnfbQPjwdqQ-01004-00659212-00659821": "my worries I think if we go there and really begin to wax lyrical about this", "fnfbQPjwdqQ-01005-00659821-00660720": "we're going to guild Lily's dog eyes and cross T's rather than address the real", "fnfbQPjwdqQ-01006-00661023-00661603": "that's helpful and like I think what you said is is helpful as well in that we", "fnfbQPjwdqQ-01007-00661603-00662200": "need to know the dose response here we need to know whether the anti antigenic", "fnfbQPjwdqQ-01008-00662200-00662745": "effect the dose response for that predicts these other downstream markers", "fnfbQPjwdqQ-01009-00662745-00663220": "and if they don't then we have to look at those we have looked at hypospadias", "fnfbQPjwdqQ-01010-00663220-00663640": "we have to look at nipple retention we have to look at others separately in", "fnfbQPjwdqQ-01011-00663640-00664123": "addition to the effect on to the anti-angiogenic effect if in fact you", "fnfbQPjwdqQ-01012-00664123-00664627": "can't look at a dose response curve for the anti androgenic response in the", "fnfbQPjwdqQ-01013-00664627-00665134": "animal and predict that yes this is where we would see nipple retention this", "fnfbQPjwdqQ-01014-00665134-00665677": "is where we would see Apple speediest hey I mean they think that's true that", "fnfbQPjwdqQ-01015-00665677-00666205": "it they follow but we need to had a spinner actually your old gray might be", "fnfbQPjwdqQ-01016-00666205-00666730": "the best person to ask about that and we may want to get into this discussion a", "fnfbQPjwdqQ-01017-00666730-00667048": "little bit more on when we talk about acceptable risk yeah because that's", "fnfbQPjwdqQ-01018-00667048-00667477": "where it becomes extremely critical I just went were just trying to identify", "fnfbQPjwdqQ-01019-00667477-00668203": "what are the endpoints that we're going to focus on um maybe we've mean for now", "fnfbQPjwdqQ-01020-00668203-00668605": "maybe we've had enough of that discussion and we could proceed to", "fnfbQPjwdqQ-01021-00668605-00669085": "thinking about you know we have a list now of endpoints and responses that we", "fnfbQPjwdqQ-01022-00669085-00669601": "would wish to use as the model and if we use these somebody else isn't going to", "fnfbQPjwdqQ-01023-00669601-00669842": "come and say well they've failed to include a", "fnfbQPjwdqQ-01024-00669842-00670466": "very important toxicological is one I mean the problem is yeah I mean the", "fnfbQPjwdqQ-01025-00670466-00670961": "problem is it's in I of the beholder and you will you know if you look", "fnfbQPjwdqQ-01026-00670961-00671761": "through the scour the literature you will find an occasional tumor site", "fnfbQPjwdqQ-01027-00671761-00672650": "parathyroid or you know the couple of studies about trying to link the", "fnfbQPjwdqQ-01028-00672650-00673238": "phthalate exposure to asthma but it's only I mean it's not it's a it's not a", "fnfbQPjwdqQ-01029-00673238-00673883": "strong link they're not strong links and they're sporadic I mean you see it with", "fnfbQPjwdqQ-01030-00673883-00674462": "one or two phthalates I'm just trying to be the devil's advocate and you know", "fnfbQPjwdqQ-01031-00674462-00675188": "there's something for everybody in there but I they're just not consistent and I", "fnfbQPjwdqQ-01032-00675188-00675971": "don't I don't see how you know that would be important to include in in", "fnfbQPjwdqQ-01033-00675971-00676430": "something where you're looking at total phthalates and I think you know to cover", "fnfbQPjwdqQ-01034-00676430-00677102": "ourselves if we need to do that in in the introduction or or someplace you", "fnfbQPjwdqQ-01035-00677102-00678056": "list all of the known adverse outcomes and then proceed to say for the effects", "fnfbQPjwdqQ-01036-00678056-00678485": "of phthalates on parathyroid tumors there's you know not enough information", "fnfbQPjwdqQ-01037-00678485-00679001": "for us to really go through an acceptable risk analysis for for that", "fnfbQPjwdqQ-01038-00679001-00679649": "endpoint and do it that way then we've we've covered our bases and and given it", "fnfbQPjwdqQ-01039-00679649-00680210": "made it transparent what it wide what is recovering and why I think we can do", "fnfbQPjwdqQ-01040-00680210-00680738": "that but I think it might also be reasonable for us to now summarize in", "fnfbQPjwdqQ-01041-00680738-00681325": "writing this list of endpoints that we think are most important for determining", "fnfbQPjwdqQ-01042-00681325-00682334": "acceptable risk and we can ask that of the Jeffrey Peters and Paul Auster and", "fnfbQPjwdqQ-01043-00682334-00682678": "others who might come in and ask if they disagree with that", "fnfbQPjwdqQ-01044-00682678-00683140": "I think that's a fair evaluation a fair opinion to seek from them and if they", "fnfbQPjwdqQ-01045-00683140-00683674": "say oh you you really missed this one well then we need to consider that can I", "fnfbQPjwdqQ-01046-00683674-00684184": "suggest to maybe also include our grain that because he's equally expert with", "fnfbQPjwdqQ-01047-00684184-00684703": "his yes as Paul I would in class i would include him sure plus has knowledge of", "fnfbQPjwdqQ-01048-00684703-00685291": "mixture effects as maybe we should invite the whole combo it's gonna be fun", "fnfbQPjwdqQ-01049-00685291-00685795": "yeah there's always a risk that we want to invite somebody who will be insulted", "fnfbQPjwdqQ-01050-00685795-00686314": "because they weren't invited but nonetheless there's you as a group have", "fnfbQPjwdqQ-01051-00686314-00686872": "a good feel for who are the greatest contributor I mean if I had a pic you", "fnfbQPjwdqQ-01052-00686872-00688119": "know three people to invite it it would be those three so yeah however still", "fnfbQPjwdqQ-01053-00688119-00688837": "taking into the consideration the task of this committee here and screening the", "fnfbQPjwdqQ-01054-00688837-00689293": "last let's say two years of literature regard in regard of epidemiological", "fnfbQPjwdqQ-01055-00689293-00690112": "evidence I see publications on the late exposure with", "fnfbQPjwdqQ-01056-00690112-00690531": "less male typical behavior in young boys", "fnfbQPjwdqQ-01057-00690540-00691407": "attention deficit or hyperactivity disorders obesity insulin resistance and", "fnfbQPjwdqQ-01058-00691407-00692188": "so on I'm not saying anything about the quality and reliability of the papers", "fnfbQPjwdqQ-01059-00692188-00692809": "and the data but still I would like to have it checked and at least discussed I", "fnfbQPjwdqQ-01060-00692809-00693442": "think it would be a shortcoming not to look into it that's what I was trying to", "fnfbQPjwdqQ-01061-00693442-00693901": "get at in terms of I think somewhere we have to have a list a table here all the", "fnfbQPjwdqQ-01062-00693901-00694267": "adverse effects that have been reported and we're not making a judgment about", "fnfbQPjwdqQ-01063-00694267-00694831": "quality of data or conclusions you're right I think that's absolutely", "fnfbQPjwdqQ-01064-00694831-00695632": "necessary but also from the standpoint that we have we don't want to be", "fnfbQPjwdqQ-01065-00695632-00696085": "criticized by the epidemiology community for looking only at", "fnfbQPjwdqQ-01066-00696085-00696819": "or rat data so I think in in order for us to not be criticized in terms of whom", "fnfbQPjwdqQ-01067-00696819-00697354": "we bring in in July to advise us on their thoughts about this we should have", "fnfbQPjwdqQ-01068-00697354-00697855": "included an epidemiologist or two if there are such people who can advise us", "fnfbQPjwdqQ-01069-00697855-00698344": "broadly on what the epidemiology literature say beyond me in addition to", "fnfbQPjwdqQ-01070-00698344-00698953": "what we can get Russ yeah I mean I agree I can do that I mean I'm familiar with", "fnfbQPjwdqQ-01071-00698953-00699321": "those studies of actually giving talk next week and that includes it's the", "fnfbQPjwdqQ-01072-00699321-00699996": "Stephanie angle study and the aggressive behavior and then Shana swans paper on", "fnfbQPjwdqQ-01073-00699996-00700596": "the play behavior and there's there's probably four or five so I am very", "fnfbQPjwdqQ-01074-00700596-00700948": "familiar with them I could you know put something together for July but we can", "fnfbQPjwdqQ-01075-00700948-00701560": "also consider potentially bringing in some of the authors if if we want but", "fnfbQPjwdqQ-01076-00701560-00702048": "it's an individual for each of those four or five papers yeah I mean that's", "fnfbQPjwdqQ-01077-00702048-00702886": "that was a big consideration in in assembling the chap and you know we", "fnfbQPjwdqQ-01078-00702886-00703435": "wanted to cover the reproductive or developmental toxicity and make sure we", "fnfbQPjwdqQ-01079-00703435-00703969": "cover it up at D me ology and if we could have had more people we would have", "fnfbQPjwdqQ-01080-00703969-00704775": "had more epidemiologists but that's definitely something we can't overlook", "fnfbQPjwdqQ-01081-00704775-00705205": "then I think we should make a decision here do we want to invite an", "fnfbQPjwdqQ-01082-00705205-00705564": "epidemiologist or do we want to rely on Russ", "fnfbQPjwdqQ-01083-00705564-00706126": "giving us a summary of I know that we will get good information and help from", "fnfbQPjwdqQ-01084-00706126-00706378": "rust well what I'm addressing is what the", "fnfbQPjwdqQ-01085-00706378-00706876": "image images I was going to say that we have two to have two issues in terms of", "fnfbQPjwdqQ-01086-00706876-00707278": "the interpretation which I feel comfortable doing but also in terms of", "fnfbQPjwdqQ-01087-00707278-00707863": "the balance and the image right of also hearing from epidemiology we could in", "fnfbQPjwdqQ-01088-00707863-00708496": "invite Shana Swan or is there someone else you might suggest there's a", "fnfbQPjwdqQ-01089-00708496-00708916": "Stephanie angle from Mount Sinai that yeah it's probably the paper you're", "fnfbQPjwdqQ-01090-00708916-00709480": "referring to Holger yeah she works with Mary wolf who's also on", "fnfbQPjwdqQ-01091-00709480-00710491": "the NRC report but I think Stephanie would be would be good was there other", "fnfbQPjwdqQ-01092-00710491-00711298": "papers ogre that you you saw it was it's it's at least reference to one two three", "fnfbQPjwdqQ-01093-00711298-00711964": "four six or seven papers right now which came up in the last couple of months so", "fnfbQPjwdqQ-01094-00711964-00712468": "I wouldn't restrict you to Stephanie angle I'm not sure maybe we should", "fnfbQPjwdqQ-01095-00712468-00712792": "discuss it in more detail later on right well she she would really just be", "fnfbQPjwdqQ-01096-00712792-00713263": "familiar with that single PM or if the main yeah yeah and I have concerns too", "fnfbQPjwdqQ-01097-00713263-00713734": "with the way they group the phthalates by molecular weight and you know but", "fnfbQPjwdqQ-01098-00713734-00714697": "that's beyond today's discussion so anyone who more of an overview of the", "fnfbQPjwdqQ-01099-00714697-00715624": "EPI field with respect to what we're interested in I'd ask in a real grade", "fnfbQPjwdqQ-01100-00715624-00716485": "like I'm a swan would have probably have more of overview okay I'd be similar to", "fnfbQPjwdqQ-01101-00716485-00717288": "my overview but I think for balancing the presentations and you know the other", "fnfbQPjwdqQ-01102-00717288-00717919": "I'm just trying to think if we invite these people in and invite testimony", "fnfbQPjwdqQ-01103-00717919-00718375": "from the public there's gonna be so we may need a you know well if it ends up", "fnfbQPjwdqQ-01104-00718375-00719497": "being a day and a half a testimony then that's that's okay I think and I think", "fnfbQPjwdqQ-01105-00719497-00719893": "Bernie you were going there too that we should formulate questions for the", "fnfbQPjwdqQ-01106-00719893-00720412": "people coming in so they have time to prepare but this was like a question", "fnfbQPjwdqQ-01107-00720412-00721125": "like you know what what percent change in testosterone would be associated with", "fnfbQPjwdqQ-01108-00721125-00721957": "X fold increased risk of hypospadias in in that study or report catism right and", "fnfbQPjwdqQ-01109-00721957-00722500": "I would just an example yes and I would hope also that by giving them", "fnfbQPjwdqQ-01110-00722500-00723142": "a lead time that they would come prepared expressed to express the", "fnfbQPjwdqQ-01111-00723142-00723685": "opinions of their colleagues as well and that we don't hear just somebody", "fnfbQPjwdqQ-01112-00723685-00724162": "reiterating what they've already said in their publications yeah there you have", "fnfbQPjwdqQ-01113-00724162-00724582": "to be tactful to get that across well without insulting them but they're not", "fnfbQPjwdqQ-01114-00724582-00725071": "just presenting their their research I mean right we have a specific question", "fnfbQPjwdqQ-01115-00725071-00725548": "yeah or question set of questions and we want their opinion but we also want what", "fnfbQPjwdqQ-01116-00725548-00725887": "their colleagues would say because they're representing their colleagues as", "fnfbQPjwdqQ-01117-00725887-00726928": "well want the state of the art so feel maybe that maybe we've taken this as far", "fnfbQPjwdqQ-01118-00726928-00727447": "as we need to at this moment if you're ready to step off into the other", "fnfbQPjwdqQ-01119-00727447-00727933": "discussion well I'm wondering in terms of now questions for these individuals", "fnfbQPjwdqQ-01120-00727933-00728656": "should we leave it at all of us will will submit questions after we review", "fnfbQPjwdqQ-01121-00728656-00729106": "whatever lurch we wish to do to Mike who will then convey them to these", "fnfbQPjwdqQ-01122-00729106-00729526": "individuals that we're inviting is that the strategy I think we would benefit", "fnfbQPjwdqQ-01123-00729526-00729946": "from some more discussion today because hearing the opinions of others is very", "fnfbQPjwdqQ-01124-00729946-00730683": "helpful at least to me you mean in terms of formulating the questions", "fnfbQPjwdqQ-01125-00730683-00731106": "well not wordsmithing but at least you know what kinds of questions do we want", "fnfbQPjwdqQ-01126-00731106-00731722": "to have them be prepared for and then we can wordsmith it and it I'll help you", "fnfbQPjwdqQ-01127-00731722-00732421": "with that Phil yeah we will also just add to it too because you want to", "fnfbQPjwdqQ-01128-00732421-00732772": "proceed developing question is ideas for", "fnfbQPjwdqQ-01129-00732772-00733165": "questions for these individuals that we're going to invite I think today we", "fnfbQPjwdqQ-01130-00733165-00733504": "need to have a discussion of what kinds of information do we want to have", "fnfbQPjwdqQ-01131-00733504-00734113": "brought to us and then who can bring that kind of information and then a", "fnfbQPjwdqQ-01132-00734113-00734593": "third approach would be what are the questions that we specifically want to", "fnfbQPjwdqQ-01133-00734593-00735696": "in to ask of Paul Foster's and Jeffery and Earl others and also as we", "fnfbQPjwdqQ-01134-00735888-00736467": "in terms of the public testimony I mean we're inviting testimony from the public", "fnfbQPjwdqQ-01135-00736467-00737301": "we could spell out the questions we have if you know like about product uses or", "fnfbQPjwdqQ-01136-00737301-00737878": "unpublished data whatever it is you know we could pose a list of questions and", "fnfbQPjwdqQ-01137-00737878-00738348": "say this is what we want here we might not get it but that's usually what we do", "fnfbQPjwdqQ-01138-00738348-00739278": "yeah yeah well let's proceed how do you want to which do you want to go back to", "fnfbQPjwdqQ-01139-00739278-00739970": "the discussion of what do we mean by acceptable risk and and develop", "fnfbQPjwdqQ-01140-00739970-00740622": "questions than that Verena wherever you want to go next yeah that", "fnfbQPjwdqQ-01141-00740622-00740934": "probably would be beneficial to do that first because that that may then", "fnfbQPjwdqQ-01142-00740934-00741478": "generate questions that we want to provide to these individuals who are", "fnfbQPjwdqQ-01143-00741478-00742251": "going to come and also to the public to do which to is just to go to the", "fnfbQPjwdqQ-01144-00742251-00743112": "discussion of what we mean by acceptable risk you want me to follow that are you", "fnfbQPjwdqQ-01145-00743112-00743721": "going to no go ahead wants to jump in on that well I think it", "fnfbQPjwdqQ-01146-00743721-00744505": "would be real easy for us to reinvent the wheel here and for someone for some", "fnfbQPjwdqQ-01147-00744505-00745071": "of you who have been involved in these discussions before at the NRC or other", "fnfbQPjwdqQ-01148-00745071-00745576": "places where you have have already had this discussion will you please start", "fnfbQPjwdqQ-01149-00745576-00746145": "this discussion for us and then we can modulate it as we go and add to add to", "fnfbQPjwdqQ-01150-00746145-00746499": "it as we go but for those of you who have already done this would you please", "fnfbQPjwdqQ-01151-00746499-00748518": "start us I think if I remember right from our discussions we started off I", "fnfbQPjwdqQ-01152-00748518-00748992": "think talking about the multiple but potential end points I mean I think we", "fnfbQPjwdqQ-01153-00748992-00749557": "did have a little bit of discussion on on cancer hepatic etc and I know Paul", "fnfbQPjwdqQ-01154-00749557-00750270": "and Kevin contributed a lot there and so I think we started off very broad but", "fnfbQPjwdqQ-01155-00750270-00751007": "then we I think relatively quickly narrowed down to the anti-angiogenic", "fnfbQPjwdqQ-01156-00751007-00751698": "testosterone effects and if I remember right I don't think we spent you know a", "fnfbQPjwdqQ-01157-00751698-00752085": "lot of time on the other end points and I think part of it was you know maybe", "fnfbQPjwdqQ-01158-00752085-00752970": "the data but also the sensitivity of the response to low-dose I mean so my", "fnfbQPjwdqQ-01159-00752970-00753369": "question would be if you've already narrowed it down when you went to the", "fnfbQPjwdqQ-01160-00753369-00753912": "NRC what is it that we're gonna get that's new from these three highly", "fnfbQPjwdqQ-01161-00753912-00754572": "qualified people the question I have is where what kind of questions are we", "fnfbQPjwdqQ-01162-00754572-00754957": "gonna ask them we're gonna repeat to say the question of what are the most", "fnfbQPjwdqQ-01163-00754957-00755493": "important effects of concern or what are the new data that can help us reduce the", "fnfbQPjwdqQ-01164-00755493-00755985": "uncertainty about this this particular suite of effects and have we learned", "fnfbQPjwdqQ-01165-00755985-00756345": "something that puts something else on the table and that would be my quest", "fnfbQPjwdqQ-01166-00756345-00756805": "this is the second part of your statement that it would be really trying", "fnfbQPjwdqQ-01167-00756805-00757323": "to you know new data it hasn't been that long but there probably is some and then", "fnfbQPjwdqQ-01168-00757323-00757724": "I think there there are thoughts about some of the questions related really to", "fnfbQPjwdqQ-01169-00757724-00758209": "developmental reproductive effects rather than you know I think we can", "fnfbQPjwdqQ-01170-00758209-00758619": "relatively quickly narrow it down but then I also think bringing in Peter", "fnfbQPjwdqQ-01171-00758619-00759132": "Jeffrey's and in terms of making sure that you know the hepatic and the liver", "fnfbQPjwdqQ-01172-00759132-00760023": "cancer is something that we should not pursue before we confirm that decision -", "fnfbQPjwdqQ-01173-00760023-00760845": "that I think I think the the aim to invite those is not really to generate", "fnfbQPjwdqQ-01174-00760845-00761399": "new information we can do we can retweet and all of us read but I think it is to", "fnfbQPjwdqQ-01175-00761399-00762186": "remove doubts that might linger about a special take which we have", "fnfbQPjwdqQ-01176-00762186-00762717": "already of the situation we all think that developmentally reproductive", "fnfbQPjwdqQ-01177-00762717-00763404": "effects are the critical ones and we think that cancer is probably not not so", "fnfbQPjwdqQ-01178-00763404-00763995": "urgent but that's my interpretation of the literature and others probably do", "fnfbQPjwdqQ-01179-00763995-00764784": "the same but I would like to have this view confirmed by the experts so only", "fnfbQPjwdqQ-01180-00764784-00765441": "that it's it's rather than emphasis on new data we can all read them it's it's", "fnfbQPjwdqQ-01181-00765441-00766092": "sort of matters relating to judging uncertainties etc etc so if you're", "fnfbQPjwdqQ-01182-00766092-00766770": "focusing a reproductive my question would be to them is is there enough", "fnfbQPjwdqQ-01183-00766770-00767454": "information to link or at least suggest the linkage between the reproductive", "fnfbQPjwdqQ-01184-00767454-00768381": "effects and the effects that occur in a young child after birth but that's very", "fnfbQPjwdqQ-01185-00768381-00768879": "difficult at that question they will not be able to answer no one no one can with", "fnfbQPjwdqQ-01186-00768879-00769260": "certainty at the moment but can you least sheds because that's gonna be a", "fnfbQPjwdqQ-01187-00769260-00769887": "critical question that we're gonna have to grapple with mmm I would love to hear", "fnfbQPjwdqQ-01188-00769887-00770376": "a discussion to me is because it's gonna be the toughest question we have a", "fnfbQPjwdqQ-01189-00770376-00770913": "critical discussion as to whether or not that those links can be made what degree", "fnfbQPjwdqQ-01190-00770913-00771561": "of uncertainty and you know what pitfalls will there be in trying to make", "fnfbQPjwdqQ-01191-00771561-00772068": "those links because you know I think if you're gonna have three highly qualified", "fnfbQPjwdqQ-01192-00772068-00772680": "people coming in they're gonna have if they're gonna help us with this task to", "fnfbQPjwdqQ-01193-00772680-00773349": "me those are the Questacon Dove questions I'd like to see answered if to", "fnfbQPjwdqQ-01194-00773349-00773928": "whatever degree possible you know yeah I mean I agree I think they they're good", "fnfbQPjwdqQ-01195-00773928-00774408": "questions that we should strive for answers to but I don't think yeah you", "fnfbQPjwdqQ-01196-00774408-00774929": "know but I I think within their respective fields they can give us", "fnfbQPjwdqQ-01197-00774929-00775482": "perspectives of the animal and the human and then you know discussing lengths but", "fnfbQPjwdqQ-01198-00775482-00775893": "I also think you know and Reggie was saying you know the new data we could", "fnfbQPjwdqQ-01199-00775893-00776415": "read but there's also there was talk about nieh s putting thirty million", "fnfbQPjwdqQ-01200-00776415-00776937": "dollars towards do thali research so be interesting to know what where they're", "fnfbQPjwdqQ-01201-00776937-00777480": "going with that I mean is so so potentially you know the new data if", "fnfbQPjwdqQ-01202-00777480-00777834": "it's published we can read it but there are kind of new directions or thoughts", "fnfbQPjwdqQ-01203-00777834-00778335": "that you know Earl and Paul can provide in terms of you know what next what are", "fnfbQPjwdqQ-01204-00778335-00778962": "the next steps the data may not be ready for for our conclusions but I think it", "fnfbQPjwdqQ-01205-00778962-00779412": "will help inform us you know if they let us know where they're going it lets us", "fnfbQPjwdqQ-01206-00779412-00779858": "know you know where some of the gaps are", "fnfbQPjwdqQ-01207-00780023-00780771": "because this acceptable risk question is something that you know I've been", "fnfbQPjwdqQ-01208-00780771-00781077": "involved in those discussions many times but I must have better I don't listen", "fnfbQPjwdqQ-01209-00781077-00781803": "real hard because there isn't something that I've had to do from day to day help", "fnfbQPjwdqQ-01210-00781803-00782517": "so help me understand if if we say that we've arrived at a decision that a risk", "fnfbQPjwdqQ-01211-00782517-00783156": "is acceptable or not acceptable for a chemical for certain age children for", "fnfbQPjwdqQ-01212-00783156-00783996": "certain endpoints is this a bright line kind of a decision or is it like we make", "fnfbQPjwdqQ-01213-00783996-00784431": "for drugs and foods and other things where there's a margin of safety that", "fnfbQPjwdqQ-01214-00784431-00785217": "you consider or is it based what what numbers do you feed into that last volt", "fnfbQPjwdqQ-01215-00785217-00786117": "when you make a decision of yes it's acceptable or not can i I well I'm aware", "fnfbQPjwdqQ-01216-00786117-00786495": "of those discussions in in the cancer arena where what is what is an", "fnfbQPjwdqQ-01217-00786495-00786921": "acceptable risk one in 1 million or something like that but that question", "fnfbQPjwdqQ-01218-00786921-00787575": "doesn't shape up like in this way in this particular arena the discussion", "fnfbQPjwdqQ-01219-00787575-00788034": "there is rather what what is an acceptable or unacceptable exposure and", "fnfbQPjwdqQ-01220-00788034-00788449": "that's that's resolved by making those come", "fnfbQPjwdqQ-01221-00788449-00789136": "since between points of departure say from relevant animal models and human", "fnfbQPjwdqQ-01222-00789136-00789788": "exposures and then judging margins of safety or etcetera etcetera but it's as", "fnfbQPjwdqQ-01223-00789788-00790453": "far as I'm aware not answerable in the sense that's done in the concert arena 1", "fnfbQPjwdqQ-01224-00790453-00791397": "in 1 million etc so we would have to rely on those our intake comparisons ok", "fnfbQPjwdqQ-01225-00791397-00791998": "for these end points that we've talked about the developmental end points we", "fnfbQPjwdqQ-01226-00791998-00792580": "would know no effect levels or we would we that's one thing that we would nail", "fnfbQPjwdqQ-01227-00792580-00793346": "down from the animal studies so then to create a ratio and a number what what is", "fnfbQPjwdqQ-01228-00793346-00793930": "the exposure data that we need to have because eventually our recommendation is", "fnfbQPjwdqQ-01229-00793930-00794644": "going to be that the level at which these phthalates are found in products", "fnfbQPjwdqQ-01230-00794644-00795053": "that children are exposed to is either acceptable it's either above them or not", "fnfbQPjwdqQ-01231-00795053-00795613": "above both a threshold that we decide yeah so we're going to recommend either", "fnfbQPjwdqQ-01232-00795613-00796261": "to lower it or leave it alone odd then what numbers do you put in that ratio", "fnfbQPjwdqQ-01233-00796261-00797107": "for us to say okay it's okay or it's not okay it if the no effect level in in an", "fnfbQPjwdqQ-01234-00797107-00797692": "animal model is one of those two numbers what's the other one the other man Bob", "fnfbQPjwdqQ-01235-00797692-00798563": "on would be in take human in take kids adults pregnant women whatever well it", "fnfbQPjwdqQ-01236-00798563-00799201": "would be if you know it's in no effective level is and you have an idea", "fnfbQPjwdqQ-01237-00799201-00799915": "what the intake is from the products were concerned with remember not totally", "fnfbQPjwdqQ-01238-00799915-00800663": "do are they within reach of one another are they three orders of magnitude", "fnfbQPjwdqQ-01239-00800663-00801044": "difference that will allow us to determine whether or not there's some", "fnfbQPjwdqQ-01240-00801044-00801659": "margin of safety we may have to apply to some number to say that this is", "fnfbQPjwdqQ-01241-00801659-00802340": "and does the way in which we use this product today provide enough margin of", "fnfbQPjwdqQ-01242-00802340-00802890": "safety for that intake to ensure that we're well below in no effect level I", "fnfbQPjwdqQ-01243-00802890-00803559": "mean that's the logic I would use okay can I just sorry Paul remind all of us", "fnfbQPjwdqQ-01244-00803559-00804225": "that we also according to the charge have to consider intake from all other", "fnfbQPjwdqQ-01245-00804225-00804786": "sources so not only from from those toys I'm sorry man terms of banning a", "fnfbQPjwdqQ-01246-00804786-00805211": "particular tie we have to look at it relatives everything else and if it's", "fnfbQPjwdqQ-01247-00805211-00805619": "minuscule compared to everything else which is what the only thing you can do", "fnfbQPjwdqQ-01248-00805619-00806307": "then you may or may not want to change the number right now or desire banning", "fnfbQPjwdqQ-01249-00806307-00806775": "it yeah I mean the question is when we talk about that everything else how", "fnfbQPjwdqQ-01250-00806775-00807276": "details does that have to be is biomonitoring good enough because that", "fnfbQPjwdqQ-01251-00807276-00807759": "gives total exposure and like Paul said you estimate exposure from the", "fnfbQPjwdqQ-01252-00807759-00808329": "children's products compare that to the total exposure or combined in a communal", "fnfbQPjwdqQ-01253-00808329-00809059": "into risk assessment and so on I don't know that we necessarily have to", "fnfbQPjwdqQ-01254-00809059-00809613": "articulate all the what all the other exposures are like so much from food so", "fnfbQPjwdqQ-01255-00809613-00810092": "much from cosmetics I mean we can but we it would be nice we don't necessarily", "fnfbQPjwdqQ-01256-00810092-00810692": "have to do that I think it says very clearly in the charts that we do yeah", "fnfbQPjwdqQ-01257-00810692-00811380": "well we said we have to can consider all sources of exposure that's right we have", "fnfbQPjwdqQ-01258-00811380-00812015": "to do that we have to we have to quantitative to the to the best again go", "fnfbQPjwdqQ-01259-00812015-00812475": "at it number six we have to quantify to the best of our ability so that when we", "fnfbQPjwdqQ-01260-00812475-00813123": "make this determination that either these products are or not a significant", "fnfbQPjwdqQ-01261-00813123-00813857": "proportion of the intake that you know we have to consider that has to be a", "fnfbQPjwdqQ-01262-00813857-00814484": "reality that we have to address and make decisions upon we just can't leave that", "fnfbQPjwdqQ-01263-00814484-00814844": "well you know we know that there's a high intake from food whoa we have to", "fnfbQPjwdqQ-01264-00814844-00815345": "really be able to provide some degree of number generation", "fnfbQPjwdqQ-01265-00815345-00815831": "plus uncertainty around those numbers and can do a comparative analysis of", "fnfbQPjwdqQ-01266-00815831-00816734": "comparative risk with respect to what we suspect would be the intake from a toy", "fnfbQPjwdqQ-01267-00816734-00817442": "or personal products that include this material in a child's world there are", "fnfbQPjwdqQ-01268-00817442-00817916": "several more specific things that I think we need to talk about one at a", "fnfbQPjwdqQ-01269-00817916-00818771": "time and Paul one of the things that you raised was the proximity of the no", "fnfbQPjwdqQ-01270-00818771-00819257": "effect levels to the exposure mm-hmm usually we look at that from the", "fnfbQPjwdqQ-01271-00819257-00819629": "standpoint of a margin of safety that's acceptable so is a thousandfold", "fnfbQPjwdqQ-01272-00819629-00820208": "difference from the noelle the the threshold of concern or is it 500 fold", "fnfbQPjwdqQ-01273-00820208-00820724": "or 10 fold or unity and what the there's there's so many different experiences", "fnfbQPjwdqQ-01274-00820724-00821195": "out there that people have had with these things that you can have a whole", "fnfbQPjwdqQ-01275-00821195-00821657": "range of numbers and you have I think we have to make our best judgment based", "fnfbQPjwdqQ-01276-00821657-00822407": "upon a number of factors including the source the frequency of use the", "fnfbQPjwdqQ-01277-00822407-00822937": "likelihood that the note the levels may increase or decrease there the number of", "fnfbQPjwdqQ-01278-00822937-00823574": "other alternative you know ways of getting it's really expert judgment at", "fnfbQPjwdqQ-01279-00823574-00823934": "that point and we're gonna have to wait awhile to come to that but it's good", "fnfbQPjwdqQ-01280-00823934-00824429": "putting it on the table that I'm concerned about there is we're not in", "fnfbQPjwdqQ-01281-00824429-00824770": "this discussion we're not pointing out the fact that for one chemical it", "fnfbQPjwdqQ-01282-00824770-00825092": "depends on what the other chemicals are it's not just the no effect level for a", "fnfbQPjwdqQ-01283-00825092-00825527": "single chemical I thought we have to have that in context two other things I", "fnfbQPjwdqQ-01284-00825527-00825983": "thought we were talking about all the Val aids we are going to be considering", "fnfbQPjwdqQ-01285-00825983-00826442": "as a group not just one that light I wasn't thinking of one that light I", "fnfbQPjwdqQ-01286-00826442-00826837": "think your point is that whether is this discussion related to one phthalates at", "fnfbQPjwdqQ-01287-00826837-00827474": "a time no or is it the composite the integral I thought but except the way to", "fnfbQPjwdqQ-01288-00827474-00828055": "get to that is to do them one or two think that you do them one at a time and", "fnfbQPjwdqQ-01289-00828055-00828549": "combine them using you know or that's one way to do it oh", "fnfbQPjwdqQ-01290-00828549-00829184": "did you mean that when you discuss margins of exposure which normally don't", "fnfbQPjwdqQ-01291-00829184-00829915": "take combined two exposures into account do you mean that we have to increase the", "fnfbQPjwdqQ-01292-00829915-00830384": "margin or make allowance for that possibly my do or maybe even play a game", "fnfbQPjwdqQ-01293-00830384-00830755": "of you know well what if these chemicals are at this", "fnfbQPjwdqQ-01294-00830755-00831076": "level then what is that margin or whatever you know some kind of a", "fnfbQPjwdqQ-01295-00831076-00831559": "sensitivity yeah that's there will be sensitivity analysis and I think that is", "fnfbQPjwdqQ-01296-00831559-00831973": "a progression as we move forward but I think your point is right we can't lose", "fnfbQPjwdqQ-01297-00831973-00832519": "sight of the fact that this is a suite of valet to not one and right and when I", "fnfbQPjwdqQ-01298-00832519-00833023": "felt comfortable with Andreas's you know presentation this morning is that we're", "fnfbQPjwdqQ-01299-00833023-00833503": "not dealing with a complex degree of synergism it looks like linear attitude", "fnfbQPjwdqQ-01300-00833503-00833986": "additive 'ti has some degree of confidence in terms of demonstrating", "fnfbQPjwdqQ-01301-00833986-00834580": "effects in the animal so I don't feel uncomfortable right now I guess kind of", "fnfbQPjwdqQ-01302-00834580-00834970": "what I'm looking for is whether there are precedents that have been set that", "fnfbQPjwdqQ-01303-00834970-00835816": "say that a tenfold margin of exposure is the standard or 100 fold well for most", "fnfbQPjwdqQ-01304-00835816-00836548": "people for if it's based on animal data would say 104 if it's human dated Stan", "fnfbQPjwdqQ-01305-00836548-00837037": "if it's children you know if you're worried about sensitive populations some", "fnfbQPjwdqQ-01306-00837037-00837919": "people might me what like a little more yeah up it a little bit but yeah 100 10", "fnfbQPjwdqQ-01307-00837919-00838330": "and 20 are the ones that I hear floated or I mean there's the sort of defaults", "fnfbQPjwdqQ-01308-00838330-00839182": "you know you could use what it you can set them at whatever you want but those", "fnfbQPjwdqQ-01309-00839182-00839662": "are the defaults I guess what I'm trying to anticipate Mike is whether we're", "fnfbQPjwdqQ-01310-00839662-00840061": "going to go 99 percent of the way to making a decision", "fnfbQPjwdqQ-01311-00840061-00840637": "and the last percent we're going to be arguing no margin of 10 isn't enough it", "fnfbQPjwdqQ-01312-00840637-00840973": "should be 15 yeah or should be 30 we might end up doing", "fnfbQPjwdqQ-01313-00840973-00841308": "that but then then it becomes a unique", "fnfbQPjwdqQ-01314-00841308-00841698": "judgment rule of this committee as opposed to a state-of-the-art kind of", "fnfbQPjwdqQ-01315-00841698-00842298": "rule not not no pressure but one of the one of the points one of the Roman", "fnfbQPjwdqQ-01316-00842298-00842874": "numerals is to use all appropriate safety factors so you know to make sure", "fnfbQPjwdqQ-01317-00842874-00843329": "you I guess that means to make sure we're protecting sensitive populations", "fnfbQPjwdqQ-01318-00843329-00843992": "and that's one approach if you for example if you don't have data for", "fnfbQPjwdqQ-01319-00843992-00844647": "juvenile males you take the adult data and add another safety factor I mean", "fnfbQPjwdqQ-01320-00844647-00845568": "that's one way to do that yes well or three years to summary whatever but if", "fnfbQPjwdqQ-01321-00845568-00846159": "you have a mechanism to say that a factor of 1.3 is scientifically", "fnfbQPjwdqQ-01322-00846159-00846503": "justified you can do that yeah but it doesn't happen very often", "fnfbQPjwdqQ-01323-00846503-00847002": "but the only thing I would add to that is to use these these considerations the", "fnfbQPjwdqQ-01324-00847002-00847560": "appropriate approaches appropriately just use them because they're there and", "fnfbQPjwdqQ-01325-00847560-00848484": "we keep adding on factors yeah we totally agree be comfortable in this", "fnfbQPjwdqQ-01326-00848484-00849578": "committee with making those decisions or do we need other outside input well", "fnfbQPjwdqQ-01327-00849578-00850050": "there's a huge list of people who would like to add their names to those who get", "fnfbQPjwdqQ-01328-00850050-00850677": "to vote on this and we can't bring them all in and we can't entertain all of", "fnfbQPjwdqQ-01329-00850677-00851385": "their biases and how to do this so I think that comes down to the comfort", "fnfbQPjwdqQ-01330-00851385-00851837": "that CPSC had pass in having selected this particular time", "fnfbQPjwdqQ-01331-00851837-00852387": "I mean we're put this way I'm comfortable with whatever the panel", "fnfbQPjwdqQ-01332-00852387-00853665": "decides okay so that that helps me having had this discussion to know that", "fnfbQPjwdqQ-01333-00853665-00854477": "we're we're in a range of a margin of safety that you know 10 to 100", "fnfbQPjwdqQ-01334-00854477-00855077": "and maybe a mark more than 100 if it is need be and we can tailor that to the", "fnfbQPjwdqQ-01335-00855077-00855598": "situation as we get there in the other question now that we've discovered", "fnfbQPjwdqQ-01336-00855598-00856054": "district frequency distributions and don't just look at point estimates now I", "fnfbQPjwdqQ-01337-00856054-00856562": "mean it is that are no one can answer this do you apply it to the average", "fnfbQPjwdqQ-01338-00856562-00856814": "exposure do you play it to the upper bound", "fnfbQPjwdqQ-01339-00856814-00857615": "you know 95th percentile you know I think it's the answer might be to the", "fnfbQPjwdqQ-01340-00857615-00858224": "meeting exposure but sometimes he use upper bound yeah you know 95th", "fnfbQPjwdqQ-01341-00858224-00858656": "percentile I mean that's where I think we should get some guidance from what I", "fnfbQPjwdqQ-01342-00858656-00859184": "well well let me put it this way you know because I mean you brought this up", "fnfbQPjwdqQ-01343-00859184-00859925": "in the data you have a 95th percentile exposure is that person at the 95th", "fnfbQPjwdqQ-01344-00859925-00860498": "percentile every day or we just hit him on a bad day you know well that's the", "fnfbQPjwdqQ-01345-00860498-00860885": "point I mean if we're gonna have somebody do some calculations of risk we", "fnfbQPjwdqQ-01346-00860885-00861299": "have to make sure that I mean expose your profiles we're gonna have to make", "fnfbQPjwdqQ-01347-00861299-00862001": "sure we understand we we define the scenario form and define in such a way", "fnfbQPjwdqQ-01348-00862001-00862604": "that we can come up with a reasonable number yeah I think that's an important", "fnfbQPjwdqQ-01349-00862604-00863018": "point chronic exposure point exposures and I", "fnfbQPjwdqQ-01350-00863018-00863450": "think in this context we might also have discussed the concept of the TDI chronic", "fnfbQPjwdqQ-01351-00863450-00863957": "exposure if it is relevant for the flights or if there is a single exposure", "fnfbQPjwdqQ-01352-00863957-00864419": "enough at a certain point in time during sexual differentiation so I think we", "fnfbQPjwdqQ-01353-00864419-00864974": "might discuss this better a single exposure might be enough to set the", "fnfbQPjwdqQ-01354-00864974-00865568": "damage and I think after the slides are Andreas is shown I think at least what", "fnfbQPjwdqQ-01355-00865568-00866102": "the red data shows there're certain windows of susceptibility but we might", "fnfbQPjwdqQ-01356-00866102-00866864": "have to take account of but I think or Paul might say something there's also a", "fnfbQPjwdqQ-01357-00866864-00867903": "discussion area under the curve for concentration and just adding is kind of", "fnfbQPjwdqQ-01358-00867903-00868365": "pharmacokinetic differences between rats and humans because I know in those", "fnfbQPjwdqQ-01359-00868365-00868895": "studies with the critical window it's a single dose but it is the half-life", "fnfbQPjwdqQ-01360-00868895-00869897": "similar or not and then how is it metabolized excedrin so any responses to", "fnfbQPjwdqQ-01361-00869897-00871260": "that comment I don't know I suspect that in humans the window is broader no it's", "fnfbQPjwdqQ-01362-00871260-00871911": "probably brought a critical window for exposure to the fetus yeah that's", "fnfbQPjwdqQ-01363-00871911-00872221": "probably I guess it depends what you mean by broader I mean it probably", "fnfbQPjwdqQ-01364-00872221-00872784": "ranges in rats it's maybe a few days I'm not that familiar of two days in humans", "fnfbQPjwdqQ-01365-00872784-00873268": "that could be first trimester right longer and weeks but potentially a", "fnfbQPjwdqQ-01366-00873268-00873993": "single point within that window may be just as relevant in a eight week window", "fnfbQPjwdqQ-01367-00873993-00874601": "as in a two-day window so that's good a", "fnfbQPjwdqQ-01368-00875276-00875967": "couple of other points that I would like to have a little more discussion on and", "fnfbQPjwdqQ-01369-00875967-00876572": "so what we've talked now about the animal data and no effect levels you", "fnfbQPjwdqQ-01370-00876572-00877484": "raised the point Andreas I think earlier about uncertainty and what they're this", "fnfbQPjwdqQ-01371-00877484-00878175": "could include the quality and quantity of data available and I think we have", "fnfbQPjwdqQ-01372-00878175-00878921": "talked about endpoints where we're not looking at a single study and somebody's", "fnfbQPjwdqQ-01373-00878921-00879315": "interpretation of a single study and the possibility that it's not even", "fnfbQPjwdqQ-01374-00879315-00879870": "repeatable we're looking at I think pretty solid endpoints here so I don't", "fnfbQPjwdqQ-01375-00879870-00880362": "think there's an uncertainty there maybe uncertainty about whether nipple", "fnfbQPjwdqQ-01376-00880362-00880815": "retention has an application to another species", "fnfbQPjwdqQ-01377-00880815-00881365": "but from the mechanistic standpoint if it's an anti-angiogenic effect it's an", "fnfbQPjwdqQ-01378-00881365-00881776": "anti-angiogenic effect that should predict other anti-angiogenic effects in", "fnfbQPjwdqQ-01379-00881776-00882298": "another species where that hormonal activity is developmentally important so", "fnfbQPjwdqQ-01380-00882298-00882804": "I'm not too worried about being able to defend that if we get into that corner", "fnfbQPjwdqQ-01381-00882804-00883437": "but from the exposure standpoint what is the quality of data and and that being", "fnfbQPjwdqQ-01382-00883437-00883852": "critical I'm expressing my lack of knowledge the quality and the quantity", "fnfbQPjwdqQ-01383-00883852-00884314": "of data for us to be able to know the exposure sufficient enough to match the", "fnfbQPjwdqQ-01384-00884314-00884845": "quality of data for the biological response it's going to be hard we're", "fnfbQPjwdqQ-01385-00884845-00885391": "gonna have a lot of uncertainties look we're going to and we're gonna have I", "fnfbQPjwdqQ-01386-00885391-00885895": "think you and I are gonna have to sit down and think about what are the", "fnfbQPjwdqQ-01387-00885895-00886477": "scenarios that are the most realistic and consider what what kind of", "fnfbQPjwdqQ-01388-00886477-00887128": "distribution functions one can ascribe to them it is it's gonna be a challenge", "fnfbQPjwdqQ-01389-00887128-00887689": "it's gonna be a challenge and for little kids it's gonna even be tougher because", "fnfbQPjwdqQ-01390-00887689-00888400": "the data is sparse on activities for kids we mean you have this you have", "fnfbQPjwdqQ-01391-00888400-00888949": "these simulations you have the the adult surveys I hate to say this but you know", "fnfbQPjwdqQ-01392-00888949-00889501": "memory of parents on what kids do is rather poor very poor we we've done", "fnfbQPjwdqQ-01393-00889501-00889810": "studies where we've had the parents felt questionnaires and we've done", "fnfbQPjwdqQ-01394-00889810-00890316": "videotaping sometimes we wonder where the parents were during the entire day", "fnfbQPjwdqQ-01395-00890316-00891012": "you know match up at all and it's it makes things a little bit cumbersome", "fnfbQPjwdqQ-01396-00891012-00891802": "when you're trying to deal with it but those problems aside we still can we can", "fnfbQPjwdqQ-01397-00891802-00892306": "still come up with some reasonably logical scenarios and it's a matter of", "fnfbQPjwdqQ-01398-00892306-00892864": "in the end where you all think and that's when it always comes back to the", "fnfbQPjwdqQ-01399-00892864-00893617": "toxicology is it the cumulative dose of all these low-level exposures is it the", "fnfbQPjwdqQ-01400-00893617-00894059": "periodic freak see of the periodicity of frequent", "fnfbQPjwdqQ-01401-00894059-00894770": "infrequent or frequent high doses these are all considerations that we have to", "fnfbQPjwdqQ-01402-00894770-00895281": "have you have to have to be able to come up with a meaningful exposure and those", "fnfbQPjwdqQ-01403-00895281-00895860": "are questions that I think we need to have answer because exposure is just not", "fnfbQPjwdqQ-01404-00895860-00896480": "a number it's a number with a biological response and a biological halftime", "fnfbQPjwdqQ-01405-00896480-00896943": "associated with somewhere well I think we're going to have to have a fairly", "fnfbQPjwdqQ-01406-00896943-00898052": "important section of a report on exposure taking into consideration about", "fnfbQPjwdqQ-01407-00898052-00898680": "sensitive periods of pregnancy and we're talking about chemicals that", "fnfbQPjwdqQ-01408-00898680-00899270": "have that are rapidly absorbed and rapidly eliminated but they're stored in", "fnfbQPjwdqQ-01409-00899270-00900279": "fact that that those two things drive some critical considerations for risk", "fnfbQPjwdqQ-01410-00900279-00900942": "and one that was made before is very important and often isn't they can into", "fnfbQPjwdqQ-01411-00900942-00901380": "giving it isn't given much consideration and that is that a single exposure at", "fnfbQPjwdqQ-01412-00901380-00902010": "the critical time can be more important than a prolonged exposure that gives you", "fnfbQPjwdqQ-01413-00902010-00902415": "the same area under the curve but may never reach a critical concentration to", "fnfbQPjwdqQ-01414-00902415-00903080": "cause the effect so that is the kind of thing that we need to put in there as", "fnfbQPjwdqQ-01415-00903080-00903480": "statements of our understanding of how to reach a judgment about risk", "fnfbQPjwdqQ-01416-00903480-00904070": "assessment and that's for one endpoint it may be will be the peak exposures but", "fnfbQPjwdqQ-01417-00904070-00904485": "for another endpoint that's correct would be the average one and also I", "fnfbQPjwdqQ-01418-00904485-00904974": "think we need to be able to address the question are there any phthalates in", "fnfbQPjwdqQ-01419-00904974-00905600": "this composite mixture that by themselves are of considerable concern", "fnfbQPjwdqQ-01420-00905600-00906245": "for risk and whether there are or not how much greater is the risk when you", "fnfbQPjwdqQ-01421-00906245-00906862": "consider the community do they have Co exposures or are they", "fnfbQPjwdqQ-01422-00906862-00907639": "different do we deal with them as a total exposure or we dealing with them", "fnfbQPjwdqQ-01423-00907639-00908269": "because they are unique in terms of the source that they can go on and be on", "fnfbQPjwdqQ-01424-00908269-00908818": "their own as a separate entity in this risk assessment but but if there are", "fnfbQPjwdqQ-01425-00908818-00909837": "there are critical questions if if we come to a conclusion that the composite", "fnfbQPjwdqQ-01426-00909861-00910456": "exposure to phthalates is what is important that doesn't help the", "fnfbQPjwdqQ-01427-00910456-00910738": "manufacturers no because their product doesn't happen", "fnfbQPjwdqQ-01428-00910738-00911194": "their product doesn't have that they have one or two phthalates and they will", "fnfbQPjwdqQ-01429-00911194-00911461": "back away from us and say well you're talking about a situation that isn't", "fnfbQPjwdqQ-01430-00911461-00912046": "ours fortunately as result wouldn't have to do anything when in fact that's why", "fnfbQPjwdqQ-01431-00912046-00912448": "we need to be able to address the individual phthalates and say yes or no", "fnfbQPjwdqQ-01432-00912448-00913387": "on them as well as the composite that's a good point not to lose because again", "fnfbQPjwdqQ-01433-00913387-00914053": "it goes back to you know we're looking at products products will have specific", "fnfbQPjwdqQ-01434-00914053-00914425": "phthalates we're not looking at one product that", "fnfbQPjwdqQ-01435-00914425-00914986": "has every salad you know the differentiation of cumulative exposure", "fnfbQPjwdqQ-01436-00914986-00915802": "versus product in single valley exposures and complicates the the", "fnfbQPjwdqQ-01437-00915802-00916291": "equation rather dramatically but it is the real world yeah so absolutely so we", "fnfbQPjwdqQ-01438-00916291-00916747": "have to focus as well so first to ignore that would be a terrible mistake it", "fnfbQPjwdqQ-01439-00916747-00917323": "would be a disaster Mike question of how we capture ideas I", "fnfbQPjwdqQ-01440-00917323-00917665": "mean there are a lot of things that we'll talk about there occasionally is", "fnfbQPjwdqQ-01441-00917665-00918055": "something that we would like to have put in the parking lot and save it to be", "fnfbQPjwdqQ-01442-00918055-00918508": "able to identify the list of things that we put in the parking lot whenever we", "fnfbQPjwdqQ-01443-00918508-00918748": "want to to make sure that we don't forget them", "fnfbQPjwdqQ-01444-00918748-00919315": "and that we have them in how can we do that I mean I'm trying to take good", "fnfbQPjwdqQ-01445-00919315-00920175": "notes and what the best thing to do might be for us to compare", "fnfbQPjwdqQ-01446-00920175-00920877": "by email after the meeting of what of action items or as things as you said", "fnfbQPjwdqQ-01447-00920877-00921606": "parking lot items I'll go through my notes and try to pick those things out", "fnfbQPjwdqQ-01448-00921606-00922412": "okay Andrea so you had a comment I'm trying to go back to your issue with", "fnfbQPjwdqQ-01449-00922412-00923118": "uncertainty which i think is a very important one the way the way I see this", "fnfbQPjwdqQ-01450-00923118-00923864": "going is as follows roughly I think we have to go through a process of", "fnfbQPjwdqQ-01451-00923864-00924410": "quantification maybe quantifying the unquantifiable by starting with", "fnfbQPjwdqQ-01452-00924410-00924843": "individual satellites and then putting it together maybe the hazard index", "fnfbQPjwdqQ-01453-00924843-00925302": "approach provides a suitable framework if we accept that that's what we would", "fnfbQPjwdqQ-01454-00925302-00925983": "have to do but then if we we must be careful in my opinion not to get too", "fnfbQPjwdqQ-01455-00925983-00926585": "hung up about numbers and taking them sort of as absolutes in view of all this", "fnfbQPjwdqQ-01456-00926585-00927039": "uncertainty we that's I think the main issue one of the main issues we have to", "fnfbQPjwdqQ-01457-00927039-00927602": "face or deal with at some point what are we going to do when we know there is", "fnfbQPjwdqQ-01458-00927602-00928373": "exposure to chemicals that have that are potential in vivo antiandrogens when we", "fnfbQPjwdqQ-01459-00928373-00928948": "know already they are active in in vitro assays we can never be sure absolutely", "fnfbQPjwdqQ-01460-00928948-00929435": "until they are tested but within the lifetime of our deliberations and this", "fnfbQPjwdqQ-01461-00929435-00930121": "committee I don't see that this situation changes at all so we can", "fnfbQPjwdqQ-01462-00930121-00930777": "before we guilt the lilies with quantifying this force alight I think we", "fnfbQPjwdqQ-01463-00930777-00931359": "have to be aware of these major sources of uncertainty and take this into", "fnfbQPjwdqQ-01464-00931359-00932087": "account by choosing better margins of exposure etc or maybe we should funnel", "fnfbQPjwdqQ-01465-00932087-00932684": "this into a qualitative question and at the end taking into account all", "fnfbQPjwdqQ-01466-00932684-00933204": "available evidence and on balance we have the opinion that", "fnfbQPjwdqQ-01467-00933204-00933752": "exposure to silage should go down or not and if the answer to that question is", "fnfbQPjwdqQ-01468-00933752-00934456": "yes then we then consider the charge in relation to proposed bans or whatever", "fnfbQPjwdqQ-01469-00934456-00935010": "but I don't think we should get too hung up about numbers and I don't think that", "fnfbQPjwdqQ-01470-00935010-00935520": "the outcome of our deliberations will be will be a risk number or something like", "fnfbQPjwdqQ-01471-00935520-00936066": "this you see what I mean and you're you're saying that we should do weight", "fnfbQPjwdqQ-01472-00936066-00936366": "of evidence in terms of how we're going to make our judgments rather than", "fnfbQPjwdqQ-01473-00936366-00936887": "suppose I think that the data situation will force us into something like that", "fnfbQPjwdqQ-01474-00936887-00938493": "we'll see and when we part part of the consideration I don't know where you put", "fnfbQPjwdqQ-01475-00938493-00939233": "this in a report is that as we talked about possibly the need to restrict the", "fnfbQPjwdqQ-01476-00939233-00939777": "inclusion of a phthalates in a product we need to be cognizant of the fact that", "fnfbQPjwdqQ-01477-00939777-00940434": "that will drive for replacement of often unknown we'll know less about the", "fnfbQPjwdqQ-01478-00940434-00940922": "replacement chemical then we will about what's being taken out as a risk", "fnfbQPjwdqQ-01479-00940922-00941409": "consideration as well we need and it doesn't it doesn't mean that we should", "fnfbQPjwdqQ-01480-00941409-00941804": "do nothing it just means that we need to be aware that that will be a consequence", "fnfbQPjwdqQ-01481-00941804-00942385": "of our decision absolutely and have that in there someplace", "fnfbQPjwdqQ-01482-00942524-00943043": "I just wanted to when you said that to put something in the parking lot and", "fnfbQPjwdqQ-01483-00943043-00943652": "that's about the alternatives because some of the XR all the experts were", "fnfbQPjwdqQ-01484-00943652-00944093": "thinking of bringing at least for the July meeting is are those that are", "fnfbQPjwdqQ-01485-00944093-00944489": "familiar with alleys but in terms of the alternatives right because that's", "fnfbQPjwdqQ-01486-00944489-00944918": "something we're going to have to yes look into so I don't know if now's the", "fnfbQPjwdqQ-01487-00944918-00945572": "time to discuss it but just to put it a bookmark there so we we know to come", "fnfbQPjwdqQ-01488-00945572-00946104": "back to that from my experience in the chemical industry people for anyone for", "fnfbQPjwdqQ-01489-00946104-00946445": "people from the major companies know what's going on and all the companies", "fnfbQPjwdqQ-01490-00946445-00947010": "and could express thinking about work how do we select alternatives and based", "fnfbQPjwdqQ-01491-00947010-00947402": "on what criteria and based on what kind of a database would a criteria what a", "fnfbQPjwdqQ-01492-00947402-00948077": "alternative be accepted be considered and if perhaps we would want to ask", "fnfbQPjwdqQ-01493-00948077-00948993": "somebody to address our alternatives selected um one possibility would be Ted", "fnfbQPjwdqQ-01494-00948993-00950162": "to ask to solicit testimony from the companies certainly but they obviously", "fnfbQPjwdqQ-01495-00950162-00950669": "have internal thinking that they don't want to share with the public right but", "fnfbQPjwdqQ-01496-00950669-00951393": "they can you know explain I'm sure there's a lot they can say yes in", "fnfbQPjwdqQ-01497-00951393-00951789": "general and I think it would be a very good discussion to have but it would be", "fnfbQPjwdqQ-01498-00951789-00952597": "good for us to hear that I'm not suggesting that we're coming close to a", "fnfbQPjwdqQ-01499-00952597-00953114": "closure on this but one thing that I would want to find out if is if anybody", "fnfbQPjwdqQ-01500-00953114-00953667": "is quite uncomfortable with the philosophy that we have been talking", "fnfbQPjwdqQ-01501-00953667-00954287": "about as an approach to making this decision because if if somebody is quite", "fnfbQPjwdqQ-01502-00954287-00954794": "uncomfortable with this general approach it would be good to have some of that", "fnfbQPjwdqQ-01503-00954794-00955454": "discussion now rather than on the day that we're trying to make a decision and", "fnfbQPjwdqQ-01504-00955454-00956177": "I'm not asking to put anybody on the spot but oh I just want us to be", "fnfbQPjwdqQ-01505-00956177-00956814": "cautious about not coming up with a number because that's gonna leave us", "fnfbQPjwdqQ-01506-00956814-00957419": "more confusion than anything else I mean we have to come up with a bright-line or", "fnfbQPjwdqQ-01507-00957419-00957995": "moderately bright line somewhere or else industry is gonna have a problem with", "fnfbQPjwdqQ-01508-00957995-00958539": "dealing with it in terms of what's coming their pot product the the other", "fnfbQPjwdqQ-01509-00958539-00958968": "communities which are concerned will have a problem dealing with what do we", "fnfbQPjwdqQ-01510-00958968-00959481": "mean by the certainty that we're ascribing to this it's we have to just", "fnfbQPjwdqQ-01511-00959481-00959778": "sit down and think hard I'm not asking for an answer", "fnfbQPjwdqQ-01512-00959778-00960234": "now I'm just saying that that as we go along these deliberations we have to", "fnfbQPjwdqQ-01513-00960234-00960819": "really consider what it is we're gonna recommend and how what form we're gonna", "fnfbQPjwdqQ-01514-00960819-00961362": "put the recommendation in so that it's understandable to all those on each side", "fnfbQPjwdqQ-01515-00961362-00962172": "of the issue it's why I second that even if you know maybe that there are parts", "fnfbQPjwdqQ-01516-00962172-00963062": "of this where we can have numbers and other parts where we can okay can I just", "fnfbQPjwdqQ-01517-00963062-00963828": "you to look at this and is the report signs and decisions this is very helpful", "fnfbQPjwdqQ-01518-00963828-00964437": "to us Dave and I don't think we can afford falling falling back behind that", "fnfbQPjwdqQ-01519-00964437-00965103": "standard and level of discussion and I sympathize if we can I'm the last to be", "fnfbQPjwdqQ-01520-00965103-00965679": "against coming up with numbers but my prediction and my feeling is that we are", "fnfbQPjwdqQ-01521-00965679-00966095": "not going to be able to do that and we have to deal with this in some otherwise", "fnfbQPjwdqQ-01522-00966095-00966720": "that's not to say we are going to be unable to come up with useful", "fnfbQPjwdqQ-01523-00966720-00967212": "recommendations I don't think that but they're probably not we have to brace", "fnfbQPjwdqQ-01524-00967212-00967587": "ourselves for the possibility that these are not going to be numbers necessarily", "fnfbQPjwdqQ-01525-00967587-00968244": "or maybe at the moment I would like a plea here to say let's keep this open", "fnfbQPjwdqQ-01526-00968244-00968973": "and let's keep suitably flexible before closing doors on certain thoughts yeah I", "fnfbQPjwdqQ-01527-00968973-00969477": "think that's good I think all of us probably have been in these committee", "fnfbQPjwdqQ-01528-00969477-00970037": "situations where we're trying to avoid a bright line because people some people", "fnfbQPjwdqQ-01529-00970037-00970428": "don't like bright lines but if one alternative that is high medium and low", "fnfbQPjwdqQ-01530-00970428-00970974": "levels of concern well there are just as many people who find that useless to", "fnfbQPjwdqQ-01531-00970974-00971394": "have some committee that understood what a low level of concern meant the day", "fnfbQPjwdqQ-01532-00971394-00971898": "that they talked about it but there is no way to explain to anybody else how", "fnfbQPjwdqQ-01533-00971898-00972381": "this translates to any other decisions so are there any alternates are there", "fnfbQPjwdqQ-01534-00972381-00972777": "any other ways to do this a way of a bright line and we have a high medium", "fnfbQPjwdqQ-01535-00972777-00973060": "and low level of concern is there any better way to do this", "fnfbQPjwdqQ-01536-00973060-00974359": "those of you who have done more of this than I have either do i well then we're", "fnfbQPjwdqQ-01537-00974359-00974818": "not going to lock us into one or the other what we're mindful of this this", "fnfbQPjwdqQ-01538-00974818-00975606": "leave our options open any investments I mean we we know it's not perfect and", "fnfbQPjwdqQ-01539-00975606-00976075": "part of the problem is we know the limitations better than the audience", "fnfbQPjwdqQ-01540-00976075-00977054": "does but you know I just don't know of a better way to do it and in terms of", "fnfbQPjwdqQ-01541-00977054-00977673": "justifying a recommendation if if the decision Dacian will be to take some", "fnfbQPjwdqQ-01542-00977673-00978339": "regulatory action you know some kind of quantification hazard index or something", "fnfbQPjwdqQ-01543-00978339-00979104": "even with the uncertainties is you know makes it a much stronger case so for", "fnfbQPjwdqQ-01544-00979104-00979677": "your purposes you don't want us to necessarily be satisfied with a high", "fnfbQPjwdqQ-01545-00979677-00979986": "medium or low level of concern you need more than that", "fnfbQPjwdqQ-01546-00979986-00980584": "right yeah well I I would think so yes because we're not going to make a", "fnfbQPjwdqQ-01547-00980584-00981018": "decision we're only going to make a recommendation true and you're the one", "fnfbQPjwdqQ-01548-00981018-00981409": "that has to tell you're going to make a decision to make a written no yes you're", "fnfbQPjwdqQ-01549-00981409-00981892": "gonna make a recommendation in fact I will make a recommendation and the five", "fnfbQPjwdqQ-01550-00981892-00982911": "commissioners will make a decision and that decision obviously has to do with", "fnfbQPjwdqQ-01551-00982911-00983789": "parts per million in a product ultimately or ultimately yes yeah", "fnfbQPjwdqQ-01552-00984108-00984576": "what other things would be good for us to discuss", "fnfbQPjwdqQ-01553-00984576-00986052": "today on this topic I mean I think after the meeting one of the things I could", "fnfbQPjwdqQ-01554-00986052-00986691": "draft something up for a federal an announcement of the next meeting and say", "fnfbQPjwdqQ-01555-00986691-00987398": "we're looking for testimony on these topics in share with the panel so you", "fnfbQPjwdqQ-01556-00987398-00987896": "could mark it up or whatever I think that's something we would want to do as", "fnfbQPjwdqQ-01557-00987896-00988656": "soon as we can and then as far as questions for the speakers I've already", "fnfbQPjwdqQ-01558-00988656-00989166": "jotted a few things down and we can continue to expand that I'm assuming", "fnfbQPjwdqQ-01559-00989166-00989546": "that that's another part of this discussion that's going to follow so I'm", "fnfbQPjwdqQ-01560-00989546-00990002": "if I'm sounding that I'm coming to a closure on that I didn't mean to yeah", "fnfbQPjwdqQ-01561-00990002-00990254": "yeah", "fnfbQPjwdqQ-01562-00990637-00991402": "one thing we might want to ask EPA and they give presentation is what level of", "fnfbQPjwdqQ-01563-00991402-00992201": "analysis they maybe I'll provide on these other sources of fallacies and", "fnfbQPjwdqQ-01564-00992201-00992879": "includes food dust and other any food to have pathway inhalation pathway in", "fnfbQPjwdqQ-01565-00992879-00993426": "dermal that since they are doing something it's important I think to get", "fnfbQPjwdqQ-01566-00993426-00993945": "an idea of where they are in the process what they can be able to provide us and", "fnfbQPjwdqQ-01567-00993945-00994343": "at one point in our process we may be able to see something that we can use", "fnfbQPjwdqQ-01568-00994343-00994767": "effectively in terms of dealing with some of these issues yeah I'm not sure", "fnfbQPjwdqQ-01569-00994767-00995412": "exactly I'm I'm gonna meet with them in a couple in a week or two I'll see what", "fnfbQPjwdqQ-01570-00995412-00995859": "I can get about where they are in their process but there you know like us", "fnfbQPjwdqQ-01571-00995859-00996516": "they're in well ones who would be looking at exposure OPP T is in a", "fnfbQPjwdqQ-01572-00996516-00997085": "regulatory mode so they might not be able to share share a lot of things I", "fnfbQPjwdqQ-01573-00997085-00997470": "don't know but who's gonna be doing the analyses the", "fnfbQPjwdqQ-01574-00997470-00998212": "well they got exposure says you've got fun or RTP well they've got for at least", "fnfbQPjwdqQ-01575-00998212-00998692": "four programs looking at phthalates right now IRA switches right just the", "fnfbQPjwdqQ-01576-00998692-00999292": "risk of art that's not exposure Oh PPT is looking at potential regulations so", "fnfbQPjwdqQ-01577-00999292-00999720": "they'll look at everything they're gonna look at the exposure assessment I think", "fnfbQPjwdqQ-01578-00999720-01000309": "clearly we need to have some information from them yeah and what they're going to", "fnfbQPjwdqQ-01579-01000309-01000806": "be able to what they're doing what the level uncertainty their data is and how", "fnfbQPjwdqQ-01580-01000806-01001308": "that can be useful to us and the sooner we get that the better yeah well I have", "fnfbQPjwdqQ-01581-01001308-01001796": "a feeling they're saying the same thing right now that what they need to get all", "fnfbQPjwdqQ-01582-01001796-01002477": "the information they can from us and from the chap but we'll see we'll find", "fnfbQPjwdqQ-01583-01002477-01003231": "out Russ actually it was pretty much the same", "fnfbQPjwdqQ-01584-01003231-01003627": "thing Paul had said I guess we were having telepathy but I was just thinking", "fnfbQPjwdqQ-01585-01003627-01004081": "in terms of a book marker again for you know EPA as we're talking about", "fnfbQPjwdqQ-01586-01004081-01004608": "information that we may want to get and pretend potentially someone to visit us", "fnfbQPjwdqQ-01587-01004608-01005106": "you know visit with us in July so just to make sure that that was on our on our", "fnfbQPjwdqQ-01588-01005106-01006197": "list well we can we can ask someone from iris and or OPP T to come and talk to oh", "fnfbQPjwdqQ-01589-01006197-01006710": "yeah there are two different processes one we have to do absolutely one which", "fnfbQPjwdqQ-01590-01006710-01007050": "is dealing with the questions that the bird was raising and the other ones the", "fnfbQPjwdqQ-01591-01007050-01007718": "questions that Holger and I and Russell just read okay absolutely and we'll", "fnfbQPjwdqQ-01592-01007718-01008531": "invite both just to complete the regulatory survey is there anything that", "fnfbQPjwdqQ-01593-01008531-01008979": "we need from does the FDA regulates a lights in a way that would be helpful to", "fnfbQPjwdqQ-01594-01008979-01010016": "us well they have authority over you know food-contact articles cosmetics", "fnfbQPjwdqQ-01595-01010016-01010627": "medical devices and there are we can certainly invite them to come", "fnfbQPjwdqQ-01596-01010627-01011389": "well we who have been talking to I've been talking to well SIF saying which", "fnfbQPjwdqQ-01597-01011389-01012540": "includes cosmetics in food packaging I guess or the main the main groups I mean", "fnfbQPjwdqQ-01598-01012540-01013235": "we can invite medical devices but that's kind of it's up to me such a narrow a", "fnfbQPjwdqQ-01599-01013235-01014181": "narrow group maybe a low priority well unless there are pediatric devices well", "fnfbQPjwdqQ-01600-01014181-01014769": "I mean there there are in in in you know little kids who have to have major", "fnfbQPjwdqQ-01601-01014769-01015720": "surgery or even preemies yeah they they can have a very intensive exposure but", "fnfbQPjwdqQ-01602-01015720-01016309": "with the benefit there's a you know it's a whole different balance it's a risk", "fnfbQPjwdqQ-01603-01016309-01016900": "benefit consideration the other can really as if you want some information", "fnfbQPjwdqQ-01604-01016900-01017289": "from several different centers in the FDA you have to invite several different", "fnfbQPjwdqQ-01605-01017289-01017682": "people it's hard to find somebody who can speak for the whole FDA that's true", "fnfbQPjwdqQ-01606-01017682-01018297": "but also we can well we'll talk I'll talk to them and see what they how much", "fnfbQPjwdqQ-01607-01018297-01018861": "they have because I don't know how how much they they really have that can be", "fnfbQPjwdqQ-01608-01018861-01019789": "helpful injuries can I suggest to invite someone from the", "fnfbQPjwdqQ-01609-01019789-01020457": "Committee on improving risk analysis yes the National Academy of Sciences that", "fnfbQPjwdqQ-01610-01020457-01021018": "reports traumas Berkey chat this he's from Johns Hopkins around the corner I", "fnfbQPjwdqQ-01611-01021018-01022445": "think that might be helpful information Tom Burke yeah yeah and yeah that's", "fnfbQPjwdqQ-01612-01022445-01023193": "that's good and they have really made specific recommendations to EPA so I", "fnfbQPjwdqQ-01613-01023193-01023787": "think we could utilize that really in which questions would you want to", "fnfbQPjwdqQ-01614-01023787-01024477": "some injuries because this would be more meta meta or concerning a framework or", "fnfbQPjwdqQ-01615-01024477-01025211": "approach to to this issue which we could use they've they have a wonderful", "fnfbQPjwdqQ-01616-01025211-01025900": "decision tree or matrix kind of stuff developed I think it would be helpful it", "fnfbQPjwdqQ-01617-01025900-01026539": "would it would not help us to address directly any questions related to", "fnfbQPjwdqQ-01618-01026539-01027120": "thyroid health risks but it would help us how to frame the problem how to go", "fnfbQPjwdqQ-01619-01027120-01027589": "about it etc etc with that part of the science and decisions yeah that's right", "fnfbQPjwdqQ-01620-01027589-01028210": "yeah he chaired that committee is that one of the discs Mike it's it's not but", "fnfbQPjwdqQ-01621-01028210-01028804": "I could look certainly look into getting it I think that I have it on my computer", "fnfbQPjwdqQ-01622-01028804-01029889": "you can have a copy straight away in fact I'll play it onto my brain with", "fnfbQPjwdqQ-01623-01029889-01030502": "that report I think the critical questions that I would like to see is", "fnfbQPjwdqQ-01624-01030502-01031014": "and they have the decision tree but how do they deal with a decision tree until", "fnfbQPjwdqQ-01625-01031014-01031531": "in in approaching the mixtures question that we're really seriously going to", "fnfbQPjwdqQ-01626-01031531-01031989": "have to quote have to deal with and I think that that's the kind of framing of", "fnfbQPjwdqQ-01627-01031989-01032694": "the discussion I think we'd like to have with with Tom so that he at least knows", "fnfbQPjwdqQ-01628-01032694-01033171": "where we're coming from and what our critical concerns are you know the end", "fnfbQPjwdqQ-01629-01033171-01033784": "points how you going extrapolation and point from reproductive to to early", "fnfbQPjwdqQ-01630-01033784-01034489": "childhood the questions of the mixtures how do you put it into something that", "fnfbQPjwdqQ-01631-01034489-01034986": "can be quantifiable I think is a good point from for departure with for him", "fnfbQPjwdqQ-01632-01034986-01035412": "because I think it's something that you've been you just articulated a", "fnfbQPjwdqQ-01633-01035412-01036446": "little while ago you're going to struggle with well I've got the report", "fnfbQPjwdqQ-01634-01036591-01038134": "whathave copy do that get the book your emails are in there there there's a page", "fnfbQPjwdqQ-01635-01038134-01038543": "somewhere with con - everybody's emails", "fnfbQPjwdqQ-01636-01038639-01039268": "let me find out where we are I I think we're done with the discussion", "fnfbQPjwdqQ-01637-01039268-01039837": "about acceptable risks and we've now morphed into this issue of what data do", "fnfbQPjwdqQ-01638-01039837-01040521": "we want for the July meeting and I don't know if we're done with that discussion", "fnfbQPjwdqQ-01639-01040521-01041121": "or not yet you had a list of questions that you're going to distribute to each", "fnfbQPjwdqQ-01640-01041121-01042312": "of us further input yes I think I saying here it is I just jotted these down", "fnfbQPjwdqQ-01641-01042312-01043018": "while we were talking yeah well I'll share this and we'll add to it or", "fnfbQPjwdqQ-01642-01043018-01043689": "whatever refine it a little bit these are just some bullets we'll try to frame", "fnfbQPjwdqQ-01643-01043689-01044460": "specific questions for like Jeff Peters and Paul Foster and so on yes so some of", "fnfbQPjwdqQ-01644-01044460-01044908": "these will have specific individuals attached yeah two of them yeah and we're", "fnfbQPjwdqQ-01645-01044908-01045321": "hoping that people who aren't experts behind these questions won't attempt to", "fnfbQPjwdqQ-01646-01045321-01046183": "answer them yeah we just don't have time but in addition you are going to be", "fnfbQPjwdqQ-01647-01046183-01047064": "contacting a broader list of people on our standing list", "fnfbQPjwdqQ-01648-01047064-01047554": "well you're right to announce what will invite those particular this specific", "fnfbQPjwdqQ-01649-01047554-01048160": "people that you requested we'll also just publish a Federal Register notice", "fnfbQPjwdqQ-01650-01048160-01048891": "and something on our website asking inviting people to present testimony", "fnfbQPjwdqQ-01651-01048891-01049596": "probably some of the people sitting here today will be presenting testimony", "fnfbQPjwdqQ-01652-01049635-01050368": "we can expect people representing the main if the valet manufacturers and so", "fnfbQPjwdqQ-01653-01050368-01051378": "on substitutes as well as others so we will do that but we can frame some", "fnfbQPjwdqQ-01654-01051378-01052214": "specific questions for them like if you we can ask about substitutes for example", "fnfbQPjwdqQ-01655-01052214-01053202": "what the process is that they go through what are the considerations and you know", "fnfbQPjwdqQ-01656-01053202-01053755": "I'll draft something up or I could unless you wanted to take the first stab", "fnfbQPjwdqQ-01657-01053755-01054324": "at it but I could draft something up like you", "fnfbQPjwdqQ-01658-01054324-01054957": "know we've done four other meetings start with that and share that with you", "fnfbQPjwdqQ-01659-01054957-01055494": "I think I think that's a helpful way to proceed so if you wanna take the first", "fnfbQPjwdqQ-01660-01055494-01056434": "crack at it yep and then we give our input okay I mean I give as long as", "fnfbQPjwdqQ-01661-01056434-01057205": "that's okay I just offering is there something more this you need from us", "fnfbQPjwdqQ-01662-01057205-01057777": "today to be able to do that today you know I don't think so I think I'm in", "fnfbQPjwdqQ-01663-01057777-01058266": "pretty good shape as far as that goes I'll you know draft stuff up and", "fnfbQPjwdqQ-01664-01058266-01059184": "circulated and I'm sure you know the panel will have a lot to add and so on", "fnfbQPjwdqQ-01665-01059184-01060414": "but we'll get started on that planning that meeting soon okay I just had a I", "fnfbQPjwdqQ-01666-01060414-01060852": "guess a question and in terms of staging of this I mean because it seems like", "fnfbQPjwdqQ-01667-01060852-01061456": "there's a lot of people and information we've listed would it be you know", "fnfbQPjwdqQ-01668-01061456-01061927": "information overload for July and then we're gonna come up with some new", "fnfbQPjwdqQ-01669-01061927-01062551": "questions and needs for next meeting which being the fall I mean as should we", "fnfbQPjwdqQ-01670-01062551-01062825": "because it sounds like there's like five to eight", "fnfbQPjwdqQ-01671-01062825-01063422": "or more presentations that we may have you know gonna be too much I was", "fnfbQPjwdqQ-01672-01063422-01063913": "wondering about that and would you want to break it up have the public testimony", "fnfbQPjwdqQ-01673-01063913-01064709": "in July and then the scientists the invited speakers at the subsequent", "fnfbQPjwdqQ-01674-01064709-01065572": "meeting or vice versa it's something something to think about I think we want", "fnfbQPjwdqQ-01675-01065572-01066704": "we want input from the experts and if we have to have but I do think we want the", "fnfbQPjwdqQ-01676-01066704-01067414": "public input to as possible so good dishes could be a day to dump July yeah", "fnfbQPjwdqQ-01677-01067414-01067793": "but I'm just wondering if you know if it's two days of full days of", "fnfbQPjwdqQ-01678-01067793-01068135": "presentations doesn't leave us a lot of time and that we're probably going to", "fnfbQPjwdqQ-01679-01068135-01068600": "come back with you know other needs I don't know I'm just thinking in terms of", "fnfbQPjwdqQ-01680-01068600-01069425": "we may want to prioritize well I think we can try it in suppo yeah I think last", "fnfbQPjwdqQ-01681-01069425-01069887": "time we had you know a day of public testimony and so if we have ended up", "fnfbQPjwdqQ-01682-01069887-01070912": "with the day and a half of listening I don't think that's too intolerable", "fnfbQPjwdqQ-01683-01071272-01071825": "digesting the information yeah so you know not that they'll you know they to", "fnfbQPjwdqQ-01684-01071825-01072263": "dump all this information on us and then we leave a few hours later but we I", "fnfbQPjwdqQ-01685-01072263-01072941": "think would need time as a panel I think the you know adjust the talks the actual", "fnfbQPjwdqQ-01686-01072941-01073484": "presentations you know we can keep them limit the time and they you know can", "fnfbQPjwdqQ-01687-01073484-01074180": "submit lots of data and give a short summary like how about if you would put", "fnfbQPjwdqQ-01688-01074180-01074777": "together an agenda okay or these public testimony both scientists EPA FDA and", "fnfbQPjwdqQ-01689-01074777-01075317": "the general public and with sometimes associated with yeah then we can start", "fnfbQPjwdqQ-01690-01075317-01075695": "to we can do that I mean the only thing is we don't know how many people are", "fnfbQPjwdqQ-01691-01075695-01076030": "going to want to give presents", "fnfbQPjwdqQ-01692-01076640-01077787": "but we can put together a straw Mian or something like that say that you know we", "fnfbQPjwdqQ-01693-01077787-01078125": "like Earl Grey to just talk with us for an hour", "fnfbQPjwdqQ-01694-01078125-01078666": "not necessarily present for an entire hour but have a dialogue going on maybe", "fnfbQPjwdqQ-01695-01078666-01079245": "that's not enough I don't know but well maybe you have the three experts for a", "fnfbQPjwdqQ-01696-01079245-01079683": "dialogue that our yes that would then maybe more that would be more effective", "fnfbQPjwdqQ-01697-01079683-01080037": "at the same time at the same time because then we won't have to I like to", "fnfbQPjwdqQ-01698-01080037-01080469": "ask the same questions over and over again we have these three very competent", "fnfbQPjwdqQ-01699-01080469-01081087": "people in the room we want to just get a information exchange yes then we will", "fnfbQPjwdqQ-01700-01081087-01081515": "need to take a more active role in the moderation of that discussion so that", "fnfbQPjwdqQ-01701-01081515-01081873": "we're not here at six o'clock in the evening from nine o'clock in the morning", "fnfbQPjwdqQ-01702-01081873-01082194": "listening to those three people yet yes we could we could devote an entire", "fnfbQPjwdqQ-01703-01082194-01083505": "morning to those folks and maybe the afternoon too from EPA FDA and but I", "fnfbQPjwdqQ-01704-01083505-01083955": "would also just caution to make sure that there's time for us so if they", "fnfbQPjwdqQ-01705-01083955-01084494": "present all morning you know block out two hours so we can talk about what they", "fnfbQPjwdqQ-01706-01084494-01085023": "presented rather than two days straight and then we all come together on the", "fnfbQPjwdqQ-01707-01085023-01085272": "third day and we don't remember what yeah right", "fnfbQPjwdqQ-01708-01085272-01085641": "if we can't internalize it it won't be of much help to have them come and just", "fnfbQPjwdqQ-01709-01085641-01086190": "talk to us have a block of time for us after each so so the depth of three", "fnfbQPjwdqQ-01710-01086190-01086646": "coming for two hours and then we block another hour where we sit and talk about", "fnfbQPjwdqQ-01711-01086646-01087447": "what they told us that would be good and of EPA and FDA and NIH s talk pocket and", "fnfbQPjwdqQ-01712-01087447-01087843": "block have a block of time at the end of that first to talk that would be fine", "fnfbQPjwdqQ-01713-01087843-01088452": "now because there will be an open public meeting we may have two hours of them", "fnfbQPjwdqQ-01714-01088452-01088761": "answering our questions but then they'll sit in the audience and hear what we say", "fnfbQPjwdqQ-01715-01088761-01088912": "about it yeah", "fnfbQPjwdqQ-01716-01088912-01089481": "that's the way they follow that's a public meeting but I mean they're you", "fnfbQPjwdqQ-01717-01089481-01090103": "that you know the chairman I mean you're inviting them you know they could sit at", "fnfbQPjwdqQ-01718-01090103-01090481": "the table if that's what you want in participate in the discussion for as", "fnfbQPjwdqQ-01719-01090481-01091447": "long as you want so are we talking about like having the invited speakers on the", "fnfbQPjwdqQ-01720-01091447-01091990": "first day I do how do we want to do this I won't be here on the first day", "fnfbQPjwdqQ-01721-01091990-01092934": "remember so it's up to you guys I'll put them on the second morning yeah okay", "fnfbQPjwdqQ-01722-01092934-01093501": "I'm here public comment first morning okay", "fnfbQPjwdqQ-01723-01093501-01094159": "other agencies in the afternoon and the experts on Monday morning or the second", "fnfbQPjwdqQ-01724-01094159-01095203": "day morning I've just emailed everyone their report so Phil I think maybe we're", "fnfbQPjwdqQ-01725-01095203-01095850": "done with this piece I'll turn it back to you no I think it's time for lunch", "fnfbQPjwdqQ-01726-01097567-01097772": "you"}}, {"audio_id": "fn-h2UfxSIQ", "text": {"fn-h2UfxSIQ-00000-00000018-00000891": "we have a vision is to have our church our family to be a praying family you know prayer was removed", "fn-h2UfxSIQ-00001-00000891-00001449": "out of the schools but it's not the problem the problem is the prayer left the homes of", "fn-h2UfxSIQ-00002-00001449-00002055": "Americans long time ago our goal is not to bring prayer back into the White House our goal is to", "fn-h2UfxSIQ-00003-00002055-00002643": "bring prayer back into your house into our house once it's in our houses it will affect the White", "fn-h2UfxSIQ-00004-00002643-00003615": "House it will affect the schools it will affect their communities yesterday I googled word prayer", "fn-h2UfxSIQ-00005-00003615-00004275": "just type prayer I found out that eight things came out eight websites came about prayer and", "fn-h2UfxSIQ-00006-00004275-00005277": "the ninth wasn't a website it was a map and on the map it had word hungry generation now", "fn-h2UfxSIQ-00007-00005277-00005844": "I understand it was catered to local searching and because somebody on hungry generation went", "fn-h2UfxSIQ-00008-00005844-00006642": "to Google and they left a review they said this is a house of God and a house of prayer so just", "fn-h2UfxSIQ-00009-00006642-00007488": "since we're at it make sure you leave a rating on Google it will help for people who search", "fn-h2UfxSIQ-00010-00007488-00008037": "prayer to see that there is a prayer going on you know five o'clock in the morning the church door", "fn-h2UfxSIQ-00011-00008037-00008754": "opens here Monday to Friday and if you're not a morning person at 6:00 to 7:00 Monday to Friday", "fn-h2UfxSIQ-00012-00008754-00009495": "even Saturdays there's prayer going on here we're believing for a time to be where constant non-stop", "fn-h2UfxSIQ-00013-00009495-00010158": "24/7 prayer going on here for the glory of God that we will bring a movement and a revival to", "fn-h2UfxSIQ-00014-00010158-00011061": "our city and to our region can somebody say Amen can somebody say Amen for many people prayer has", "fn-h2UfxSIQ-00015-00011061-00011787": "become a garbage dump where you dump your problems your worries and you go only to prayer as your", "fn-h2UfxSIQ-00016-00011787-00012366": "last resort instead of as a priority I was getting a haircut recently and a lady who was cutting my", "fn-h2UfxSIQ-00017-00012366-00012819": "hair she she asked me what I do for living and so I asked I told her that I work at the church and", "fn-h2UfxSIQ-00018-00012819-00013227": "I'm a pastor and so she looked around quickly if there was anybody else and she says can I ask you", "fn-h2UfxSIQ-00019-00013227-00013813": "a question so the fact that she looked around told me that it's gonna get spiritual and so I was like", "fn-h2UfxSIQ-00020-00013813-00014290": "of course throw throwing my way we have next 15 minutes and so and she says sister telling me her", "fn-h2UfxSIQ-00021-00014290-00015076": "prayer request she says ooh is it okay that I pray this prayer to God of course I said of course it's", "fn-h2UfxSIQ-00022-00015076-00015922": "okay to break the god I said but I'm not really sure that you're ready for the answer I'm like", "fn-h2UfxSIQ-00023-00015922-00016531": "prayer is not just so you get the burden off of your shoulders it's so you can get the answer and", "fn-h2UfxSIQ-00024-00016531-00016930": "I'm like the kind of prayer that you're praying that you're telling me right now I have a feeling", "fn-h2UfxSIQ-00025-00016930-00017374": "I know what the answer is gonna be because I pray the same prayer many times and I'm like I'm not", "fn-h2UfxSIQ-00026-00017374-00017836": "sure you're ready for the answer and she wasn't interested in the answer she was just making sure", "fn-h2UfxSIQ-00027-00017836-00018427": "it's okay to pray and I was a girl you got green light go for a pray and pray and pray all the time", "fn-h2UfxSIQ-00028-00018427-00019027": "and people pray people who don't come to church pray Jesus actually say said he didn't spray", "fn-h2UfxSIQ-00029-00019027-00019486": "means people who don't have a relationship with God pray and they think that the more words they", "fn-h2UfxSIQ-00030-00019486-00019858": "give to God the more chances they have to be heard by God and Jesus says that's not really how it", "fn-h2UfxSIQ-00031-00019858-00020425": "works Jesus says hypocrites pray means people who pray to get approval from people or pray thinking", "fn-h2UfxSIQ-00032-00020425-00020701": "it gonna it's gonna give him brownie points in heaven you know they can give him a higher", "fn-h2UfxSIQ-00033-00020701-00021175": "chance of actually making it to heaven people pray everywhere but Jesus introduced different", "fn-h2UfxSIQ-00034-00021175-00021826": "kind of prayer to his disciples he says but when you pray pray differently because he didn't tell", "fn-h2UfxSIQ-00035-00021826-00022363": "us to pray to a God who is so distant he didn't pray us to pray to a god who is religious ruler", "fn-h2UfxSIQ-00036-00022363-00022822": "he says when you come to prayer come as kids to the Father and address him as your father not", "fn-h2UfxSIQ-00037-00022822-00023296": "as your Creator not as your Savior not as your healer not as your deliverer not as the one who", "fn-h2UfxSIQ-00038-00023296-00023884": "supplies you needs according to his riches and his glory as your dad it gives different meaning", "fn-h2UfxSIQ-00039-00023884-00024397": "to prayer and when Jesus introduced prayer one of the first times that Jesus prayed I want you", "fn-h2UfxSIQ-00040-00024397-00024922": "to see what happened when he prayed because this becomes the model of what makes prayer different", "fn-h2UfxSIQ-00041-00024922-00025420": "why many people are frustrated with prayer why many people give up on prayer why many people", "fn-h2UfxSIQ-00042-00025420-00026074": "are disappointed in prayer is because your and my prayer sometimes misses the mark of how Jesus", "fn-h2UfxSIQ-00043-00026074-00026670": "wants us to pray if we will strive to pray like Jesus wants us to pray there will be rejuvenating", "fn-h2UfxSIQ-00044-00026670-00027361": "refreshing reviving it will change their life it will be so powerful the people around you will ask", "fn-h2UfxSIQ-00045-00027361-00028006": "teach me how to pray disciples of Jesus didn't ask Jesus teach us how to heal the sick they didn't", "fn-h2UfxSIQ-00046-00028006-00028483": "ask Jesus Jesus teach us how to walk on water they were so impressed with how his prayer life", "fn-h2UfxSIQ-00047-00028483-00029386": "was they said Jesus teach us how to pray I want you to see this in Luke chapter 3 verse 21 when", "fn-h2UfxSIQ-00048-00029386-00030027": "all were gathering all people were baptized by the way baptism next Sunday it came to pass that Jesus", "fn-h2UfxSIQ-00049-00030027-00030832": "was also baptized another reason to get baptized Jesus did get baptized and while he prayed see", "fn-h2UfxSIQ-00050-00030832-00031468": "when we have people getting out of baptism they usually go WOW when Jesus got out of the Baptist", "fn-h2UfxSIQ-00051-00031468-00032155": "Bible ciske was getting out of the I mean Jesus was such a powerful prayer warrior he was praying", "fn-h2UfxSIQ-00052-00032155-00032502": "on the cross he was praying in the garden he was praying on the mountains he was praying early", "fn-h2UfxSIQ-00053-00032502-00033046": "Bible says often early would draw himself in the wilderness and here Jesus is praying in Baptism", "fn-h2UfxSIQ-00054-00033046-00033601": "he's getting out of the River Jordan and the Bible says and while he was praying something happened", "fn-h2UfxSIQ-00055-00033601-00034699": "the heaven was open the Holy Spirit descended in the bodily form like a dove upon him and the voice", "fn-h2UfxSIQ-00056-00034699-00035278": "from heaven came saying this is my beloved son that is a different prayer than what usually we're", "fn-h2UfxSIQ-00057-00035278-00035758": "accustomed to this wasn't prayer where Jesus was casting his anxieties and God and saying God you", "fn-h2UfxSIQ-00058-00035758-00036244": "know how life is hard this was a different prayer and he had a different result I want you to I want", "fn-h2UfxSIQ-00059-00036244-00036718": "to point out just few little nuggets from this prayer this prayer was birthed out of obedience", "fn-h2UfxSIQ-00060-00036718-00037447": "not the spiration Jesus didn't have a problem he was facing he was obedient to his father and out", "fn-h2UfxSIQ-00061-00037447-00038011": "of obedience this prayer was born if the only time you are praying is when you're sick you're", "fn-h2UfxSIQ-00062-00038011-00038512": "missing the point of prayer if the only time you fasting and you're seeking God if the tragedy has", "fn-h2UfxSIQ-00063-00038512-00039070": "hits that is not the prayer Jesus wants us to have Jesus one-cell prayer to be based and climbing out", "fn-h2UfxSIQ-00064-00039070-00039646": "of obedience not just out of our knees or out of those desperation and then we see not only that he", "fn-h2UfxSIQ-00065-00039646-00040132": "was praying out of obedience as he was repeating to the father in getting baptized we see that his", "fn-h2UfxSIQ-00066-00040132-00040882": "prayer it opened the windows of heaven heaven was open the spiritual forces that were this", "fn-h2UfxSIQ-00067-00040882-00041392": "sometimes combat you know us on this earth and God in heaven and they want to block that the", "fn-h2UfxSIQ-00068-00041392-00041944": "principalities they were shifted and the heaven was open sea prayer is earth giving heaven a", "fn-h2UfxSIQ-00069-00041944-00042703": "license to interfere sin is earth giving demons to interfere when you pray you clear out the heavens", "fn-h2UfxSIQ-00070-00042703-00043411": "your goal in prayer is not just to get what you want your goal in prayer is not just to lift the", "fn-h2UfxSIQ-00071-00043411-00044080": "anxieties and the war is your goal in prayer is make sure heavens get open because when heavens", "fn-h2UfxSIQ-00072-00044080-00044662": "get open whatever is from here goes up there and whatever is there comes down here and that's why", "fn-h2UfxSIQ-00073-00044662-00045130": "sometimes worship becomes the way the heavens is open and we see the next thing that happens is the", "fn-h2UfxSIQ-00074-00045130-00046024": "Holy Spirit comes on Jesus I love when in prayer you walk out feeling a lighter you told your needs", "fn-h2UfxSIQ-00075-00046024-00046756": "to God you feel so much better but that's not this prayer Jesus had no demons to lose during prayer", "fn-h2UfxSIQ-00076-00046756-00047479": "God doesn't want you to limit prayer to getting route the demons he wants you to pursue further", "fn-h2UfxSIQ-00077-00047479-00048148": "war in prayer you get filled with another spirit when another spirit comes on you the Holy Spirit", "fn-h2UfxSIQ-00078-00048148-00048766": "in this world there are demons and demons cause pain and demons cause sickness and demons cause", "fn-h2UfxSIQ-00079-00048766-00049372": "calamities unwanted things they cause premature death they cause mental breakdowns demons they", "fn-h2UfxSIQ-00080-00049372-00049816": "bring fear they bring bondage they bring heaviness they're a cause of affliction the Bible clearly", "fn-h2UfxSIQ-00081-00049816-00050299": "states that they come to steal kill and destroy and prayer is the place where you walk into God", "fn-h2UfxSIQ-00082-00050299-00050803": "and heaven begins to open and those demons they begin to lift but it's not just so you can go", "fn-h2UfxSIQ-00083-00050803-00051433": "and get another demon to come again to prayer it's so that the Spirit can descend on you the golden", "fn-h2UfxSIQ-00084-00051433-00051954": "prayer is not just so God can give me what I want it so that God can give you someone you need it's", "fn-h2UfxSIQ-00085-00051954-00052825": "the Holy Spirit come on somebody the Holy Spirit descended the Bible says and the voice of God", "fn-h2UfxSIQ-00086-00052825-00053671": "spoke you don't see Jesus experiencing a miracle here you don't see Jesus having money getting a", "fn-h2UfxSIQ-00087-00053671-00054298": "car finding a wife Jesus not experiencing a breakthrough here but he hears God's voice", "fn-h2UfxSIQ-00088-00054298-00054976": "actually after this prayer he went through a very trying times the goal of prayer is not just so", "fn-h2UfxSIQ-00089-00054976-00055582": "God can hear you he said that you can hear him if prayer is reduced to you talking and talking", "fn-h2UfxSIQ-00090-00055582-00056197": "and talking and talking so you can feel better it's a one-way street God did not intend prayer", "fn-h2UfxSIQ-00091-00056197-00056833": "to be a one-way street what's more important than getting what you need is hearing God who speaks to", "fn-h2UfxSIQ-00092-00056833-00057492": "you and many people in prayer they literally see a prayer like a garbage bag will you come you dump", "fn-h2UfxSIQ-00093-00057492-00058039": "the problems you quickly leave and next week you dump more and you dump when God comes and picks", "fn-h2UfxSIQ-00094-00058039-00058501": "that up picks that up and that's fine if you are there spiritually but I wanted to use something", "fn-h2UfxSIQ-00095-00058501-00059044": "Jesus introduces a different model of Prayer he says I want you to live a life of obedience and", "fn-h2UfxSIQ-00096-00059044-00059536": "out of that obedience pray I want you to seek in prayer to see the heaven comes down on earth", "fn-h2UfxSIQ-00097-00059536-00060192": "in prayer I want you to begin to feel my spirit not just simply wrestle with the demons not just", "fn-h2UfxSIQ-00098-00060192-00060724": "wrestle with the forces of the enemy but I want you to feel my spirit and in prayer walk out even", "fn-h2UfxSIQ-00099-00060724-00061357": "if you don't get a miracle make sure you hear my voice because Paul was praying three times that", "fn-h2UfxSIQ-00100-00061357-00061852": "the thorn will be removed but the Torn wasn't removed but Paul still heard God's voice Jesus", "fn-h2UfxSIQ-00101-00061852-00062332": "prayed three times father let your will please take away the suffering from me and though the", "fn-h2UfxSIQ-00102-00062332-00062764": "father didn't grant his petition but the Angels came and supported him meaning there was a", "fn-h2UfxSIQ-00103-00062764-00063274": "presence of God that was there something that is more important in getting requests your request", "fn-h2UfxSIQ-00104-00063274-00063862": "man and that is to know the voice of the Holy Spirit who guides you and leaves you and tells", "fn-h2UfxSIQ-00105-00063862-00064363": "you listen I am with you I know your kid is not turning around but I'm working on them I know your", "fn-h2UfxSIQ-00106-00064363-00064885": "health may not be turning around but I am your healer when you feel the voice of God you will", "fn-h2UfxSIQ-00107-00064885-00065614": "go to prayer again you will go through life again your situation might not change but you will does", "fn-h2UfxSIQ-00108-00065614-00066229": "somebody say Amen I want us to see that Jesus not only he prayed on this earth but Jesus goes up to", "fn-h2UfxSIQ-00109-00066229-00067015": "heaven and he remains a prayer warrior in heaven I want us to look at the scripture what it says", "fn-h2UfxSIQ-00110-00067015-00067741": "in Romans chapter 8 who is he who condemns it is Christ who died and furthermore it is also risen", "fn-h2UfxSIQ-00111-00067741-00068353": "who is even at the right hand of God we know that Jesus rose from the dead Easter we know that he is", "fn-h2UfxSIQ-00112-00068353-00068962": "sitting at the right hand of God and then this is what Romans says who also makes intercession", "fn-h2UfxSIQ-00113-00068962-00069568": "for us so while being in heaven Jesus is not sipping on a kool-aid he's not resting chilling", "fn-h2UfxSIQ-00114-00069568-00070009": "and chillaxing he's not just watching over the balcony of eternity how we're all struggling", "fn-h2UfxSIQ-00115-00070009-00070483": "and going through stuff and just waiting for you know Antichrist to show up so he can kill him and", "fn-h2UfxSIQ-00116-00070483-00071101": "squash him like a bug and come back and establish his kingdom Jesus is not passive in heaven Jesus", "fn-h2UfxSIQ-00117-00071101-00071707": "is actually very occupied and for those of you who think in his building your mansion in heaven", "fn-h2UfxSIQ-00118-00071707-00072232": "I'm actually he's building his kingdom on earth by interceding for us on this earth right now", "fn-h2UfxSIQ-00119-00072232-00073045": "he's busy praying not just busy relaxing if he's praying in heaven for us I think we should also", "fn-h2UfxSIQ-00120-00073045-00073744": "pray on earth for us Hebrews chapter 7 verse 25 therefore he is able to save to the uttermost", "fn-h2UfxSIQ-00121-00073744-00074473": "those who come to God through him since he always lives to makes interest to make intercession for", "fn-h2UfxSIQ-00122-00074473-00075136": "them Jesus Christ in heaven right now is praying he's not preaching he's running he's not running", "fn-h2UfxSIQ-00123-00075136-00075796": "a crusade he's not singing worship songs he's praying which tells us that the highest calling", "fn-h2UfxSIQ-00124-00075796-00076594": "any Christian can have is not to be a prophet an apostle it's to be an intercessor is to pray is to", "fn-h2UfxSIQ-00125-00076594-00077092": "have the access to God and begin to plead before God on things on this earth you might say why is", "fn-h2UfxSIQ-00126-00077092-00077626": "Jesus praying in heaven first of all as long as there is devil on earth there needs to be prayer", "fn-h2UfxSIQ-00127-00077626-00078121": "as long as there's one person that does not know God that their sins were already paid for on the", "fn-h2UfxSIQ-00128-00078121-00078613": "cross there needs to be prayer offered as long as there's one person addicted to drugs and this", "fn-h2UfxSIQ-00129-00078613-00079075": "earth there needs to be prayer offered as long as there's one family that's facing tragedy there", "fn-h2UfxSIQ-00130-00079075-00079555": "needs to be prayer offered as long as there's one person battling arthritis or battling cancer there", "fn-h2UfxSIQ-00131-00079555-00080047": "needs to be prayer offered and Jesus doesn't see it as a time to take break because if there", "fn-h2UfxSIQ-00132-00080047-00080650": "is somebody hurting on this earth he says heaven has to be busy praying and he says I'm not gonna", "fn-h2UfxSIQ-00133-00080650-00081202": "delegate prayer to a Gabrielle or to Michael or to another arc angel I will actually lead this", "fn-h2UfxSIQ-00134-00081202-00082249": "ministry myself I will spend time praying for my people in Luke chapter 22 verse 31 it says right", "fn-h2UfxSIQ-00135-00082249-00082792": "before his crucifixion before going to the trial jesus said to Simon he said the Lord said Simon", "fn-h2UfxSIQ-00136-00082792-00083548": "Simon indeed Satan has asked for you that he may sift you as wheat but I prayed for you that your", "fn-h2UfxSIQ-00137-00083548-00084304": "faith will not fail and when you have returned to me strengthen your brethren so this is an example", "fn-h2UfxSIQ-00138-00084304-00084811": "of what it's like when Jesus prays for you what I want to get out of it is this Jesus praying for", "fn-h2UfxSIQ-00139-00084811-00085588": "you does very little for you unless you pray for you Jesus prayed for Simon and he told Simon he", "fn-h2UfxSIQ-00140-00085588-00086068": "told Peter he says Peter I've been praying for you by the way Peter do you know why I've been", "fn-h2UfxSIQ-00141-00086068-00086635": "praying for you because the devil's been praying against you so not only you have Jesus praying for", "fn-h2UfxSIQ-00142-00086635-00087166": "you you have devil praying against you the Bible calls him the accuser of brethren the story of job", "fn-h2UfxSIQ-00143-00087166-00087784": "confirms that that devil got jealous over job he went to God and start literally trashing job to", "fn-h2UfxSIQ-00144-00087784-00088375": "God he's saying bad things to job and in this case devil comes to God and he stirs saying bad things", "fn-h2UfxSIQ-00145-00088375-00088966": "about Peter so Jesus comes to God and he begins to intercede for Peter one of the reasons Jesus", "fn-h2UfxSIQ-00146-00088966-00089974": "intercedes for you because Devils talking smack about you and Jesus tells Peter Satan has actually", "fn-h2UfxSIQ-00147-00089974-00090760": "been praying and I've been praying but Peter I want you to listen to this watch and you pray", "fn-h2UfxSIQ-00148-00090760-00091423": "lest you enter into temptation Peter my praying and Satan's praying is not gonna really tilt the", "fn-h2UfxSIQ-00149-00091423-00092020": "scales what's gonna tilt the scales Peter is will you watch and pray and we know Peter was sleeping", "fn-h2UfxSIQ-00150-00092020-00092524": "instead of spraying and so guess what happened Peters start going back it's interesting that", "fn-h2UfxSIQ-00151-00092524-00093175": "this is the first time Jesus calls Peter Simon twice Jesus changed his name from Simon which", "fn-h2UfxSIQ-00152-00093175-00093811": "means unstable Peter means like a rock and Jesus refers for the first time to Peter according to", "fn-h2UfxSIQ-00153-00093811-00094327": "his last name a last name that he used to have according to his old nature and he's a Simon", "fn-h2UfxSIQ-00154-00094327-00094777": "Simon why is he saying that because every time you opt to prayerlessness you will always repeat your", "fn-h2UfxSIQ-00155-00094777-00095572": "past if you don't pray you stray if you don't pray you start going back to your old nature all things", "fn-h2UfxSIQ-00156-00095572-00096067": "begin to come back old friends begin to reach out when we don't pray just because Jesus is praying", "fn-h2UfxSIQ-00157-00096067-00096517": "for us yes it gives us the boost but there is a devil that is demons who are actually combating", "fn-h2UfxSIQ-00158-00096517-00097165": "us and Jesus was playing for us is saying pray with me I care so much about you that I pray for", "fn-h2UfxSIQ-00159-00097165-00097603": "you could you care a little bit about yourself that you pray with me for yourself because if", "fn-h2UfxSIQ-00160-00097603-00098371": "you don't pray you'll enter into temptation a lot of times people find themselves overcoming certain", "fn-h2UfxSIQ-00161-00098371-00098884": "issue or certain habits certain pain certain thing in the past and you're doing fine but you have to", "fn-h2UfxSIQ-00162-00098884-00099427": "understand if you don't maintain a lifestyle of Prayer and dependency on God your Simon", "fn-h2UfxSIQ-00163-00099427-00100048": "may appear again for some people Simon is weed for some people Simon is anger for some people", "fn-h2UfxSIQ-00164-00100048-00100540": "Simon is pornography for some people Simon is chronic depression a chronic anxiety for others", "fn-h2UfxSIQ-00165-00100540-00101083": "Simon is just it's just being insecure whatever your Simon is I want to tell you something your", "fn-h2UfxSIQ-00166-00101083-00101503": "Simon is waiting for you to sleep instead of praying and he wants to come back and become", "fn-h2UfxSIQ-00167-00101503-00102184": "who you used to be but today is the time for the Simon to stay Simon in your past and for you to", "fn-h2UfxSIQ-00168-00102184-00103018": "act like Peter by saying Jesus I will pray with you come on somebody when we don't live a life of", "fn-h2UfxSIQ-00169-00103018-00103477": "Prayer not only we will stray instead of praying but like Peter we will live out of our emotion", "fn-h2UfxSIQ-00170-00103477-00104329": "instead of devotional Peter made a lot of promises I'll go with you Jesus I'll die for you he was a", "fn-h2UfxSIQ-00171-00104329-00105082": "big talker and when it came to the actual doing something slept cuss like a sailor there now is", "fn-h2UfxSIQ-00172-00105082-00105871": "Jesus three times I went back to his always every time you your devotion is really measured not on", "fn-h2UfxSIQ-00173-00105871-00106683": "how big you can talk it's how long you can walk with God everybody can talk to talk everybody can", "fn-h2UfxSIQ-00174-00106683-00107044": "raise their hands one of your favorite song is playing when we are in the atmosphere of", "fn-h2UfxSIQ-00175-00107044-00107533": "believers but it's about battle with the blankets in the morning it's about battle with the spirit", "fn-h2UfxSIQ-00176-00107533-00108036": "of slumber in the afternoon where you really want to go home and just watch the watch the", "fn-h2UfxSIQ-00177-00108036-00108529": "stranger things or other stuff stranger things on Netflix and but you know the Holy Spirit is", "fn-h2UfxSIQ-00178-00108529-00108885": "pulling you and he says listen but let's girls come to prayer you know that you know the church", "fn-h2UfxSIQ-00179-00108885-00109429": "is open it from 6:00 to 7:00 you could come and but I'm so busy you've been playing golf", "fn-h2UfxSIQ-00180-00109429-00109969": "every day for the past three years you can skip one time and there is that battle that happens", "fn-h2UfxSIQ-00181-00109969-00110455": "but you made so many promise you see people who don't live a life of prayer always over-promised", "fn-h2UfxSIQ-00182-00110455-00110938": "and under-delivered because they feel guilty and so they constantly make big bigger promises new", "fn-h2UfxSIQ-00183-00110938-00111589": "year's resolutions next next year I'm gonna pray more listen promise less do more less talking more", "fn-h2UfxSIQ-00184-00111589-00112828": "walking less emotion more devotion and just live a life of prayer when we don't pray we begin to warm", "fn-h2UfxSIQ-00185-00112828-00113661": "ourselves at the wrong fire Peter quickly went from cursing to being in a fire with people who", "fn-h2UfxSIQ-00186-00113661-00114285": "were against Jesus and the crazy part he actually tried to fit him he tried to be like them I think", "fn-h2UfxSIQ-00187-00114285-00114799": "he threw a few bad words around just to you know to make him understand I am NOT a Galilee and I", "fn-h2UfxSIQ-00188-00114799-00115408": "am not belonging to Jesus they quickly found out that he's a bad bad hypocrite they said weren't", "fn-h2UfxSIQ-00189-00115408-00115975": "you with Jesus and he just throws few little F in this F and dad no no blank this but was as he", "fn-h2UfxSIQ-00190-00115975-00116857": "was cursing God didn't call you to fit in you were anointed to stand out well when you pray", "fn-h2UfxSIQ-00191-00117039-00117911": "Eagles don't try to earn the high opinions of chicken and lions don't lose sleep over the", "fn-h2UfxSIQ-00192-00117911-00118626": "opinions of sheep God gave you royalty inside God gave you authority inside but when you don't live", "fn-h2UfxSIQ-00193-00118626-00119208": "a life of prayer you become subject to popular opinion you become too scared of what people", "fn-h2UfxSIQ-00194-00119208-00119808": "will say you'll become too scared of this and then you try to fit into the clubs to the group's God", "fn-h2UfxSIQ-00195-00119808-00120606": "called you to change and influence prayerlessness is deadly you may say but Jesus is praying for me", "fn-h2UfxSIQ-00196-00120606-00121092": "that's not really what's going to change your life what's going to change your life is when", "fn-h2UfxSIQ-00197-00121092-00121806": "Jesus will pray with you not just for you you know what Jesus tells Peter Peter eventually goes and", "fn-h2UfxSIQ-00198-00121806-00122376": "starts to catch fish he can't catch fish Jesus prepares a breakfast at sea and he calls Peter", "fn-h2UfxSIQ-00199-00122376-00123021": "he says Peter and it's like almost like in like an irony he says have you caught anything remember", "fn-h2UfxSIQ-00200-00123021-00123635": "Peter is a professional fisherman fishing all night he just ran away from God and Jesus says", "fn-h2UfxSIQ-00201-00123635-00124296": "Peter have you caught anything and Peter says no Jesus I haven't caught anything I'm empty I've", "fn-h2UfxSIQ-00202-00124296-00124797": "been fishing all night I'm empty and Jesus said well since you're empty I got some fish right", "fn-h2UfxSIQ-00203-00124797-00125285": "here come over the Bible says Peter jumped in the lake and he started to swim to Jesus and", "fn-h2UfxSIQ-00204-00125285-00125877": "when he got there he had this meeting with Jesus in the morning breakfast with Jesus and there", "fn-h2UfxSIQ-00205-00125877-00126294": "was this fish there was already stuff prepared and Jesus starts to ask a question Peter do you", "fn-h2UfxSIQ-00206-00126294-00126852": "love me Peter do you love me and the relationship with Peter was restored with God you really want", "fn-h2UfxSIQ-00207-00126852-00127484": "to kick the prayerlessness in the gear have a breakfast with Jesus Jesus is waiting for you", "fn-h2UfxSIQ-00208-00127484-00128031": "at the shore with the revelation and with his presence and with his spirit and he's calling", "fn-h2UfxSIQ-00209-00128031-00128502": "you from your empty life maybe he's calling you from prayerlessness and he says I know you blew", "fn-h2UfxSIQ-00210-00128502-00128936": "it I know you made a new year's resolution I know you made a decision to read the Bible but", "fn-h2UfxSIQ-00211-00128936-00129366": "your Bible app has been deleted it hasn't been even open in the past seven months I know that", "fn-h2UfxSIQ-00212-00129366-00130083": "come to me let's have a breakfast let's begin to meet in the morning let's begin to continue that", "fn-h2UfxSIQ-00213-00130083-00130890": "you see Jesus but I blew it as I know I can change you we can start from here no I'm a backslider no", "fn-h2UfxSIQ-00214-00130890-00131511": "Peter you've been an apostate but I'm about to make you an apostle a breakfast can change your", "fn-h2UfxSIQ-00215-00131511-00132387": "life with Jesus maybe maybe you're not like Peter maybe you're not a morning person you sing Jesus", "fn-h2UfxSIQ-00216-00132387-00133056": "I can't hear you in the morning some sleepy you know to the church in Revelation that lost the", "fn-h2UfxSIQ-00217-00133056-00133596": "passion for God Jesus says behold I stand at the door and I knock and he who hears my voice and", "fn-h2UfxSIQ-00218-00133596-00134232": "opens the door I will dine with him so to all the night owls Jesus is saying I'll meet you at", "fn-h2UfxSIQ-00219-00134232-00135012": "night I'll knock at night if that's if you wake up after 11 p.m. let's do it a 12th aisle let's dine", "fn-h2UfxSIQ-00220-00135012-00135444": "together if you can't help reckless with me let's have a dinner with me but I want to meet with you", "fn-h2UfxSIQ-00221-00135444-00135942": "I want to be with you and that will change your life can somebody say Amen come on somebody I", "fn-h2UfxSIQ-00222-00135942-00136698": "know we have people here who feel like if you're not a morning person you can't be with God because", "fn-h2UfxSIQ-00223-00136698-00137100": "everything is about morning it's not just about breakfast sometimes Jesus wants to dine with", "fn-h2UfxSIQ-00224-00137100-00137616": "people and if you're here today and you don't wake up until 10 o'clock shame on you by the", "fn-h2UfxSIQ-00225-00137616-00138129": "way but Jesus is not guilt-tripping it this guy may be guilt tripping you but Jesus saying good", "fn-h2UfxSIQ-00226-00138129-00138747": "tripping you Jesus is saying I'll knock at 5 p.m. I'll knock at 6 p.m. and I want to dine with you", "fn-h2UfxSIQ-00227-00138747-00139302": "if your breakfast is too early dinner is not too late and I want to meet you there I want to meet", "fn-h2UfxSIQ-00228-00139302-00139740": "you at your time I want to meet with I want to have a relationship with you can somebody say", "fn-h2UfxSIQ-00229-00139740-00140802": "Amen cuz we gonna come to a time of benefits of Prayer if you don't spend time with Jesus and you", "fn-h2UfxSIQ-00230-00140802-00141807": "are a believer you either have no idea who Jesus is or you have no idea who you are the reason why", "fn-h2UfxSIQ-00231-00141807-00142443": "we approach God is because he's our Father if you don't pray you're either for God who's your daddy", "fn-h2UfxSIQ-00232-00142443-00143172": "are you simply for God whose kid you are if you don't pray you either for God who's your daddy", "fn-h2UfxSIQ-00233-00143172-00144048": "oh you forgot whose kid you are maybe you became employee instead of God's child maybe you become", "fn-h2UfxSIQ-00234-00144048-00145056": "God's errand boy instead of God's children because if you have a parent and your dad is loaded you", "fn-h2UfxSIQ-00235-00145056-00145572": "will be talking to him I don't care differences you have with him I don't care your views of point", "fn-h2UfxSIQ-00236-00145572-00146145": "you will be calling him you will be not just for his presence not just but for his presence for his", "fn-h2UfxSIQ-00237-00146145-00146733": "help for his connections for everything and God is loaded silver and gold his mind says the Lord I", "fn-h2UfxSIQ-00238-00146733-00147303": "give power to God has strength God has everything not just money but peace and joy and righteousness", "fn-h2UfxSIQ-00239-00147303-00147936": "and he's surprised that his kids don't call his kids don't come but they do sometimes you know", "fn-h2UfxSIQ-00240-00147936-00148341": "mow his lawn they do sometimes take care of things and God looks and he says why aren't we talking", "fn-h2UfxSIQ-00241-00148341-00148857": "on the talking terms I'm your dad I'm not just your Creator your master your boss I'm not just", "fn-h2UfxSIQ-00242-00148857-00149403": "your Lord the king and sovereign Messiah I am your father didn't my son taught you to come to", "fn-h2UfxSIQ-00243-00149403-00150156": "me and say our Father who is in heaven did you forget who you are did you forget who I am but", "fn-h2UfxSIQ-00244-00150156-00151053": "for us as Christians not only God is her father but Jesus is a bridegroom we are his wife imagine", "fn-h2UfxSIQ-00245-00151053-00151779": "a husband who treats his wife like a house maid who's on good terms she doesn't cheat on him he", "fn-h2UfxSIQ-00246-00151779-00152427": "doesn't beat her she cooks he provides the money she goes to one room he goes to another room they", "fn-h2UfxSIQ-00247-00152427-00152814": "don't exchange words they don't communicate they don't say anything against each other that means", "fn-h2UfxSIQ-00248-00152814-00153438": "two people have either forgot who they are when a believer does not spend time with Jesus he for", "fn-h2UfxSIQ-00249-00153438-00154155": "God he or she is the Bride of Christ and Jesus is the lover the first commandment Jesus didn't give", "fn-h2UfxSIQ-00250-00154155-00154608": "us is to clean my house and watch over my kingdom his first commandment is love the Lord your God", "fn-h2UfxSIQ-00251-00154608-00155058": "with all your heart soul and mind which means Jesus wasn't intending to start a new religion", "fn-h2UfxSIQ-00252-00155058-00155646": "there's plenty of them he was planning to start a romantic intimate relationship when we don't talk", "fn-h2UfxSIQ-00253-00155646-00156165": "to him in marriage in relationship communication is the blood if there is no blood there is no", "fn-h2UfxSIQ-00254-00156165-00156795": "life if there is no prayer there is no life in her relationship only dead rustic dead boring", "fn-h2UfxSIQ-00255-00156795-00157581": "predictable teen cult religion there was a queen in the Bible two queens I call him the the tails", "fn-h2UfxSIQ-00256-00157581-00158130": "of two queens the queen vashti book of esther is a beautiful book Queen Vashti was a queen", "fn-h2UfxSIQ-00257-00158130-00158688": "and she was a wife of the king the King planned a big banquet for the man and queen decided not", "fn-h2UfxSIQ-00258-00158688-00159201": "to waste any time got the wives of those men and decided to do a little little meeting for them as", "fn-h2UfxSIQ-00259-00159201-00159744": "well she was the probably the first woman in the Bible started the women's ministry big banquet", "fn-h2UfxSIQ-00260-00159744-00160308": "and during the banquet the king decided to call his wife to show her beauty and to be with her", "fn-h2UfxSIQ-00261-00160308-00161013": "in front of his royal team his royal kings and the wife of the king who was so busy with the women's", "fn-h2UfxSIQ-00262-00161013-00162018": "ministry she says I can't come I'm not going why I'm busy and the King's leg excuse me that's my", "fn-h2UfxSIQ-00263-00162018-00162738": "palace that's my food you're giving to your women who you think you are woman did you forget you're", "fn-h2UfxSIQ-00264-00162738-00163368": "not my servant you're not my concubine you are my wife your first duty is not to please the woman", "fn-h2UfxSIQ-00265-00163368-00163860": "your first duty is to be with me and the Bible says because of that act which was not cheating", "fn-h2UfxSIQ-00266-00163860-00164559": "or unfaithfulness it was an act of busyness which hindered her seeing the king she lost her crown", "fn-h2UfxSIQ-00267-00164559-00165024": "she didn't lose her life she didn't lose her place in the palace most likely she became a", "fn-h2UfxSIQ-00268-00165024-00165669": "concubine she acted like a concubine instead of acting like a wife you know it's interesting in", "fn-h2UfxSIQ-00269-00165669-00166233": "Ephesians church and if Ephesus Church of Ephesus in Revelation was doing everything for Jesus it", "fn-h2UfxSIQ-00270-00166233-00166686": "was working hard for Jesus it was patient for Jesus it was everything and Jesus rides to the", "fn-h2UfxSIQ-00271-00166686-00167169": "Church of Ephesus and he says through John he says you are so incredible you're working so", "fn-h2UfxSIQ-00272-00167169-00167667": "hard you're putting in overtime I see you're like really really just doing so much I'm so proud of", "fn-h2UfxSIQ-00273-00167667-00168594": "you but he says I have one problem you don't love me this is you working for me I can get", "fn-h2UfxSIQ-00274-00168594-00169452": "angels to work for me but are you not an angel you my wife I don't just expect your duties I expect", "fn-h2UfxSIQ-00275-00169452-00170263": "your desire your passion and he says this if you don't change I'll remove your lampstand meaning", "fn-h2UfxSIQ-00276-00170263-00170896": "if you don't act like a wife I won't act like a husband there will be no intimacy between us", "fn-h2UfxSIQ-00277-00170896-00171334": "you'll continue to work you'll continue go to heaven but that's not why I bought you with my", "fn-h2UfxSIQ-00278-00171334-00172120": "precious blood I bought you to be my wife and I love you with unfailing unfailing unconditional", "fn-h2UfxSIQ-00279-00172120-00172852": "love and I want you to make it a priority in the midst of your business to remember you're not my", "fn-h2UfxSIQ-00280-00172852-00173524": "servant you're my wife spend time with me fall in love with me again and again what you're doing is", "fn-h2UfxSIQ-00281-00173524-00174157": "great applause you're gonna get the reward but I want intimacy so Astor comes on the scene after", "fn-h2UfxSIQ-00282-00174157-00174895": "Vashti and Esther who was a queen she doesn't see the king for about 30 days and Esther's nation", "fn-h2UfxSIQ-00283-00174895-00175420": "is about to be destroyed as the Jewish nation is about to be completely wiped out and Esther was a", "fn-h2UfxSIQ-00284-00175420-00175999": "Jewish girl and so Esther has this pressure Esther has this burden and she wants to go now tell the", "fn-h2UfxSIQ-00285-00175999-00176416": "King about this problem and instead of that I want you to see the comparison the difference", "fn-h2UfxSIQ-00286-00176416-00177013": "Esther doesn't leave the women to feast she leaves the women to fast she can so all the women in the", "fn-h2UfxSIQ-00287-00177013-00177562": "court is the head girls it's time to lose those pounds three days I know you're not Jewish I know", "fn-h2UfxSIQ-00288-00177562-00177976": "you might not care about what's going on with me but we are gonna go fast why because before I go", "fn-h2UfxSIQ-00289-00177976-00178621": "to the King I gotta break through the spiritual realm and then she comes to the King uninvited", "fn-h2UfxSIQ-00290-00178621-00179221": "the King doesn't invite her the King doesn't ask for her she invites herself and this is a little", "fn-h2UfxSIQ-00291-00179221-00179794": "lesson for each one of us you don't have to wait until you feel to pray to pray the Bible says draw", "fn-h2UfxSIQ-00292-00179794-00180811": "near to me and I will draw near to you sometimes you take the initiative some people say well I", "fn-h2UfxSIQ-00293-00180811-00181318": "don't feel God is drawing me why don't you try yourself because the scripture says in the New", "fn-h2UfxSIQ-00294-00181318-00181987": "Testament draw near to God push yourself to God and God says the moment you make your steps toward", "fn-h2UfxSIQ-00295-00181987-00182578": "me I'll extend the scepter I'll extend my mercy means I will meet you halfway if you start going", "fn-h2UfxSIQ-00296-00182578-00183085": "on my back yard like a father to the prodigal son I'll run to meet you don't always wait for", "fn-h2UfxSIQ-00297-00183085-00183633": "God to give you the desire and push you or maybe use the problems in your life push you on your", "fn-h2UfxSIQ-00298-00183633-00184254": "knees listen you're an adult push yourself make yourself oh it's so hard to do that it's easy to", "fn-h2UfxSIQ-00299-00184254-00184692": "do that with the remote control it's easier to do that with prayer just tell yourself make up", "fn-h2UfxSIQ-00300-00184692-00185259": "your mind I'm gonna see God if God pulls me or not I'm gonna proceed God and Esther she steps", "fn-h2UfxSIQ-00301-00185259-00185799": "into the palace of the king the King extends the scepter and I want you to see something Esther", "fn-h2UfxSIQ-00302-00185799-00186828": "does not ask the King about her life why because the Jewish girl can wait the wife cannot what's", "fn-h2UfxSIQ-00303-00186828-00187647": "more important than her problems is her position and her identity and her identity is a wife not a", "fn-h2UfxSIQ-00304-00187647-00188430": "Jewish girl and she says my problems they can wait two more days but Who I am I don't want", "fn-h2UfxSIQ-00305-00188430-00189006": "to lose that world is falling apart people are going to lose their lives I know but the only", "fn-h2UfxSIQ-00306-00189006-00189609": "thing they can change that is if I be a wife and she doesn't tell the King please we need to talk", "fn-h2UfxSIQ-00307-00189609-00190431": "about the problem she says King I have a feast for you why because I am your wife vast she prepared a", "fn-h2UfxSIQ-00308-00190431-00191238": "king feast for the women Esther prepared a feast for a husband vast she had no problems Esther had", "fn-h2UfxSIQ-00309-00191238-00191787": "only problems because see Esther didn't just have cancer didn't just have family falling apart she", "fn-h2UfxSIQ-00310-00191787-00192387": "faced death for all of her family tree that she knew close and extended and that's worse than any", "fn-h2UfxSIQ-00311-00192387-00193011": "sickness and any family trauma or any problem when you're facing death and the clock is ticking but", "fn-h2UfxSIQ-00312-00193011-00193572": "even then she pushed the problems to the side and says I'll deal with you two days later but I first", "fn-h2UfxSIQ-00313-00193572-00194472": "need to be a wife and when she was a wife to her King she gave him a feast something happened the", "fn-h2UfxSIQ-00314-00194472-00195120": "next day she gave him a feast again and this is where the change happen the man who was against", "fn-h2UfxSIQ-00315-00195120-00195798": "her his name was Haman he came there as well and this is the biggest mistake Haman met and", "fn-h2UfxSIQ-00316-00195798-00196818": "made in his life he did not know who Esther was he thought she was just a beautiful girl in the court", "fn-h2UfxSIQ-00317-00196818-00198144": "he did not know he was messing with the wife of a king who knew she was the wife of the king on the", "fn-h2UfxSIQ-00318-00198144-00198933": "second feast when she presented a prayer request and says King I'm not asking you for money I'm not", "fn-h2UfxSIQ-00319-00198933-00199554": "asking you for gold I just asked you for my life and the lives of my people that's all she says", "fn-h2UfxSIQ-00320-00199554-00200199": "if we become slaves I'm fine I just don't want to die yet our fears were drowned in His perfect love", "fn-h2UfxSIQ-00321-00200199-00200925": "and the Bible says this when the King heard that he walked off the palace and Haman were so bold", "fn-h2UfxSIQ-00322-00200925-00201744": "who was so strong he mailed before Esther and start begging for mercy why because he realized", "fn-h2UfxSIQ-00323-00201744-00202680": "he was messing with the wife of a king and Esther didn't play a Jewish girl she played a royalty in", "fn-h2UfxSIQ-00324-00202680-00203418": "the midst of a mess in her life don't ever stop worshipping God because you got waters in your", "fn-h2UfxSIQ-00325-00203418-00204096": "life don't ever stop loving God because you got Labour's in your life and don't ever trade your", "fn-h2UfxSIQ-00326-00204096-00204576": "problems for this presence or trade the palace or trade this presence for this path for this", "fn-h2UfxSIQ-00327-00204576-00204996": "presence I mean don't ever cause the problems to become a distraction don't ever other things", "fn-h2UfxSIQ-00328-00204996-00205533": "why because it's in those things when you stand and who you are before God even if your world is", "fn-h2UfxSIQ-00329-00205533-00206100": "falling apart even if your health is failing but you're saying god I know these problems they're", "fn-h2UfxSIQ-00330-00206100-00206717": "important but if I die one second after my death they're not important cancer is not important to", "fn-h2UfxSIQ-00331-00206717-00207261": "one second after your death all of your financial problems are not important one second after your", "fn-h2UfxSIQ-00332-00207261-00207810": "death you know what's important one second after your death is who you are and therefore you don't", "fn-h2UfxSIQ-00333-00207810-00208308": "want to give the secondary things that don't matter when you die a highest priority when you", "fn-h2UfxSIQ-00334-00208308-00208989": "stand in the presence of everlasting and eternal King who is your husband come somebody say Amen I", "fn-h2UfxSIQ-00335-00208989-00209942": "want to challenge each person this morning during this Christmas season Jesus Christ is not a baby", "fn-h2UfxSIQ-00336-00209942-00210687": "in the manger he seated as a king and he happens to be your husband if you are a Christian now for", "fn-h2UfxSIQ-00337-00210687-00211176": "those who may be men and the word Jesus is your husband offends you get used to it in heaven you", "fn-h2UfxSIQ-00338-00211176-00211796": "won't have a gender the only change that you will have is that you will be loved on by the creator", "fn-h2UfxSIQ-00339-00211796-00212406": "of the universe Jesus Christ God is your father come to him as a kid Jesus is your husband come", "fn-h2UfxSIQ-00340-00212406-00212883": "to him as his wife that's why as a Christian if you don't pray you either forgot who you are or", "fn-h2UfxSIQ-00341-00212883-00213473": "you forgot who God is you have to pray you have to live a life of intimacy with God why because", "fn-h2UfxSIQ-00342-00213473-00213888": "jesus paid a dear price to be able to have that intimacy prayer is not a garbage dump", "fn-h2UfxSIQ-00343-00213888-00214461": "it's not a spare tire it's an intimate scene it's a relationship with God amen hi there if", "fn-h2UfxSIQ-00344-00214461-00215133": "you're like me and you like to click on things go ahead and click right here and subscribe to our", "fn-h2UfxSIQ-00345-00215133-00215769": "YouTube channel in this way we'll be able to send the content to you directly and each week you'll", "fn-h2UfxSIQ-00346-00215769-00216258": "stay updated with the things that we post thank you so much for watching and have a wonderful day"}}, {"audio_id": "gom_iHyrKvE", "text": {}}, {"audio_id": "goqGfHXXUIQ", "text": {"goqGfHXXUIQ-00000-00000000-00000816": "Hi, I'm Celine Jacquin, I'm part of the Humanitarian OpenStreetMap Team's Alpha Hub of Latin America", "goqGfHXXUIQ-00001-00000819-00001528": "I'm in Mexico City and I'm a participant of OpenStreetMap Mexico,", "goqGfHXXUIQ-00002-00001528-00002206": "OpenStreetMap Latam, Geochicas, a community where we seek to improve diversity", "goqGfHXXUIQ-00003-00002209-00002647": "in the Open Source communities, and the OpenStreetMap communities,", "goqGfHXXUIQ-00004-00002647-00003102": "and therefore in the Alpha Hub, that is, in this six-month period,", "goqGfHXXUIQ-00005-00003106-00003842": "what we are looking for is to experiment with different types of projects, different governance models,", "goqGfHXXUIQ-00006-00003845-00004899": "to improve the ways that HOT has to collaborate in the region, increase its understanding of local problems,", "goqGfHXXUIQ-00007-00004902-00005335": "ways of collaborating with local organizations and different communities", "goqGfHXXUIQ-00008-00005338-00005835": "of the Open Source world, universities, NGOs, groups,", "goqGfHXXUIQ-00009-00005835-00006321": "with different areas that are related to what humanitarian and sustainable development .", "goqGfHXXUIQ-00010-00006467-00007217": "In the next semester there will be the Hub and much more activities will start there. Greetings."}}, {"audio_id": "goEudnwCUVY", "text": {"goEudnwCUVY-00001-00000097-00000457": "Australia warmly welcomes international students and today I would like to talk to you", "goEudnwCUVY-00002-00000459-00000723": "about applying to study in Australia.", "goEudnwCUVY-00003-00000725-00001175": "The student visa programme provides an opportunity for people to study in Australia in", "goEudnwCUVY-00004-00001177-00001694": "an internationally recognised, secure and culturally diverse learning environment.", "goEudnwCUVY-00005-00001696-00002123": "The student visa programme is important for the department and Australia in general", "goEudnwCUVY-00006-00002125-00002604": "because international students help to strengthen bilateral ties, enrich our social and", "goEudnwCUVY-00007-00002606-00003066": "cultural fabric and contribute significantly to our economy.", "goEudnwCUVY-00008-00003068-00003479": "Prospective students can apply for one of seven different student visas, depending on", "goEudnwCUVY-00009-00003481-00003789": "the type of study they wish to undertake.", "goEudnwCUVY-00010-00003790-00004286": "Courses available to international students vary from short English language courses,", "goEudnwCUVY-00011-00004288-00004719": "right through to doctoral degrees.", "goEudnwCUVY-00012-00004721-00005015": "Certain students are permitted to lodge their visa application online, while others are", "goEudnwCUVY-00013-00005017-00005255": "required to lodge paper applications.", "goEudnwCUVY-00014-00005257-00005703": "More information about choosing a student visa and lodging an application is available on", "goEudnwCUVY-00015-00005705-00005998": "the department's website.", "goEudnwCUVY-00016-00006000-00006397": "In order to be granted a visa, students must be able to demonstrate they're enrolled", "goEudnwCUVY-00017-00006399-00006897": "in an eligible course, have enough money to support themselves while in Australia, have", "goEudnwCUVY-00018-00006898-00007328": "sufficient English language skills for the course they wish to study and satisfy the", "goEudnwCUVY-00019-00007330-00007738": "department they are genuine temporary entrants.", "goEudnwCUVY-00020-00007740-00008168": "To be granted a visa, students must:  demonstrate they are enrolled in a course", "goEudnwCUVY-00021-00008170-00008487": "have enough money to support themselves  have sufficient language English language skills", "goEudnwCUVY-00022-00008489-00008816": "be a genuine temporary entrant.", "goEudnwCUVY-00023-00008818-00009124": "Once granted a visa, student visa holders are expected to comply with their visa", "goEudnwCUVY-00024-00009126-00009409": "conditions; these include satisfying the attendance and course progress requirements set", "goEudnwCUVY-00025-00009411-00009665": "by their education provider, and not working more than 40 hours per fortnight.", "goEudnwCUVY-00026-00009667-00009957": "The Minister for Immigration and Border Protection recently announced some proposed", "goEudnwCUVY-00027-00009959-00010211": "changes to the student visa program, which will benefit future student visa applicants.", "goEudnwCUVY-00028-00010213-00010491": "These include:    extending streamlined visa processing to some non-university higher", "goEudnwCUVY-00029-00010493-00010930": "education providers and  proposed changes to simplify the Assessment Level Framework", "goEudnwCUVY-00030-00010932-00011327": "through the removal of Assessment Level  4 and 5, and a reduction in financial", "goEudnwCUVY-00031-00011329-00011673": "requirements for Assessment Level 3 applicants.", "goEudnwCUVY-00032-00011675-00012105": "These changes will make the visa application process simpler and easier for genuine", "goEudnwCUVY-00033-00012107-00012305": "international students.", "goEudnwCUVY-00034-00012307-00012802": "We expect to be able to implement these changes in early 2014.", "goEudnwCUVY-00035-00012804-00013191": "Some students who've completed their studies may be eligible to apply for a temporary", "goEudnwCUVY-00036-00013193-00013388": "graduate visa.", "goEudnwCUVY-00037-00013391-00013846": "This visa allows students to gain valuable work experience in Australia for up to four", "goEudnwCUVY-00038-00013847-00014376": "years, depending on the course they've studied, before returning home.", "goEudnwCUVY-00039-00014378-00015213": "For more information visit www.immi.gov.au today."}}, {"audio_id": "goRgqRbXtSI", "text": {"goRgqRbXtSI-00000-00000012-00000468": "Thank you for watching candlestick trading videohi long which pairs do you think are", "goRgqRbXtSI-00001-00000468-00000587": "the best for trading.", "goRgqRbXtSI-00002-00000587-00000951": "I get confused on knowing which pairs to trade.", "goRgqRbXtSI-00003-00000951-00001513": "kind regards I recommend EURUSD", "goRgqRbXtSI-00004-00001513-00002297": "because spread is tight and also trade volume higher than another pair", "goRgqRbXtSI-00005-00002297-00002338": "Thank you"}}, {"audio_id": "g08clXpOrkY", "text": {"g08clXpOrkY-00000-00002471-00002597": "Subscribe Us"}}, {"audio_id": "g0-zP72KNFo", "text": {"g0-zP72KNFo-00000-00000000-00000900": "♫ music ♫", "g0-zP72KNFo-00001-00000900-00001090": "( ͡° ͜ʖ ͡°)", "g0-zP72KNFo-00002-00001791-00002083": "( ͡° ͜ʖ ͡°)", "g0-zP72KNFo-00003-00002083-00002133": "ho...?", "g0-zP72KNFo-00004-00002133-00002406": "♫ spook music ♫", "g0-zP72KNFo-00005-00002406-00002536": "*wolf noise*", "g0-zP72KNFo-00006-00002536-00002803": "*hungry wolf noise*", "g0-zP72KNFo-00007-00002803-00002911": "be quiet please.", "g0-zP72KNFo-00008-00002911-00002961": "EHO?!", "g0-zP72KNFo-00009-00003205-00003422": "*more wolf noise*", "g0-zP72KNFo-00010-00003430-00003630": "Cooking with Wolf & Shadows!", "g0-zP72KNFo-00011-00003683-00003733": "BEUa?!", "g0-zP72KNFo-00012-00003796-00003846": "woah?", "g0-zP72KNFo-00013-00003946-00004046": "f o o d !", "g0-zP72KNFo-00014-00004089-00004139": "oof?!", "g0-zP72KNFo-00015-00004139-00004236": "what da fak?", "g0-zP72KNFo-00016-00004236-00004349": "PLEASE HELP ME!", "g0-zP72KNFo-00017-00004463-00004577": "*the sound of midas*", "g0-zP72KNFo-00018-00004658-00004823": "i'm gonna turn them into things beyond corpse.", "g0-zP72KNFo-00019-00004890-00004956": "t h i n k !", "g0-zP72KNFo-00020-00004956-00005094": "m a g i c    p l a t e  !", "g0-zP72KNFo-00021-00005167-00005240": "*happy wolf noises*", "g0-zP72KNFo-00022-00005608-00005916": "♫ spy music ♫", "g0-zP72KNFo-00023-00005916-00006137": "let's team up and fix the choppa", "g0-zP72KNFo-00024-00006201-00006333": "we'll make a good team!", "g0-zP72KNFo-00025-00006333-00006436": "g o l d . . . . .", "g0-zP72KNFo-00026-00006458-00006820": "g i v e . . . . . . . . . . . . . . . . . . . . !", "g0-zP72KNFo-00027-00006820-00006881": "mmmmm?", "g0-zP72KNFo-00028-00006881-00006997": "bone with hair?", "g0-zP72KNFo-00029-00006997-00007047": "AAAAAA-", "g0-zP72KNFo-00030-00007117-00007167": "huh?", "g0-zP72KNFo-00031-00007167-00007239": "where chop part?!", "g0-zP72KNFo-00032-00007239-00007289": "and friend?", "g0-zP72KNFo-00033-00007318-00007397": "ma ha hA!", "g0-zP72KNFo-00034-00007397-00007500": "*censored for child purpose*", "g0-zP72KNFo-00035-00007661-00007738": "dAAAA?!", "g0-zP72KNFo-00036-00007738-00007830": "grandma chicken?!", "g0-zP72KNFo-00037-00007905-00007992": "good luck with it!", "g0-zP72KNFo-00038-00008032-00008082": "alright!", "g0-zP72KNFo-00039-00008132-00008238": "( ͡° ͜ʖ ͡°)", "g0-zP72KNFo-00040-00008238-00008288": "AAAAAA-", "g0-zP72KNFo-00041-00008419-00008564": "♫ not russian music ♫", "g0-zP72KNFo-00042-00009210-00009363": "it's done.", "g0-zP72KNFo-00043-00009417-00009592": "*meow meow meow*", "g0-zP72KNFo-00044-00009611-00009793": "right. we should go", "g0-zP72KNFo-00045-00009827-00009971": "jules should drive", "g0-zP72KNFo-00046-00010023-00010074": "hmph!", "g0-zP72KNFo-00047-00010074-00010124": "k, dad.", "g0-zP72KNFo-00048-00010349-00010579": "*THE SCREAM OF EVERYTHING THAT MOVES*", "g0-zP72KNFo-00049-00010806-00010856": "WAIT!", "g0-zP72KNFo-00050-00010856-00010972": "don't you want a cup of tea-?", "g0-zP72KNFo-00051-00011210-00011260": "HMM!", "g0-zP72KNFo-00052-00011260-00011310": "*meow?!*", "g0-zP72KNFo-00053-00011310-00011489": "HEY THAT SEAT IS TAKEN!", "g0-zP72KNFo-00054-00011489-00011584": "*loads doot device with malicious intent*", "g0-zP72KNFo-00055-00011691-00011991": "I?! ♫ DOOT ♫", "g0-zP72KNFo-00056-00011991-00012214": "♫ UNGLYPH MASTER RAZ ♫", "g0-zP72KNFo-00057-00012214-00012348": "♫  D O O T  ♫", "g0-zP72KNFo-00058-00012348-00012744": "♫   D  O  O  T   ♫", "g0-zP72KNFo-00059-00013807-00013947": "( ͡° ͜ʖ ͡°)", "g0-zP72KNFo-00060-00013947-00014147": "i don't need any of you now", "g0-zP72KNFo-00061-00014159-00014209": "huhu", "g0-zP72KNFo-00062-00014377-00014410": "NOOOO-", "g0-zP72KNFo-00063-00014410-00014755": "♫ THE END ♫", "g0-zP72KNFo-00064-00014755-00014805": "kit?", "g0-zP72KNFo-00065-00014805-00015005": "DAD?!", "g0-zP72KNFo-00066-00015096-00015383": "*wide brutus*", "g0-zP72KNFo-00067-00015454-00015504": "EH?!", "g0-zP72KNFo-00068-00015504-00015655": "PUT ME DOWN!", "g0-zP72KNFo-00069-00015803-00015952": "*NOT HERE!*", "g0-zP72KNFo-00070-00016152-00016541": "( ͡° ͜ʖ ͡°)", "g0-zP72KNFo-00071-00016541-00016617": "ah......", "g0-zP72KNFo-00072-00016617-00016826": "that free umbrella will be mine!", "g0-zP72KNFo-00073-00016826-00017026": "*low fuel noise*", "g0-zP72KNFo-00074-00017130-00017475": "♫ heavy music ♫", "g0-zP72KNFo-00075-00017475-00017814": "♫ h e a v y music ♫", "g0-zP72KNFo-00076-00017814-00018507": "♫  h  e  a  v  y   music ♫", "g0-zP72KNFo-00077-00018507-00018600": "*out of fuel*", "g0-zP72KNFo-00078-00018600-00019015": "*choppa dies*", "g0-zP72KNFo-00079-00019015-00019065": "*boom*", "g0-zP72KNFo-00080-00019438-00019826": "♫ cluck music ♫", "g0-zP72KNFo-00081-00020273-00020589": "use code \"ispuddy\"! and enjoy tea"}}, {"audio_id": "g0NoqnwNCRg", "text": {"g0NoqnwNCRg-00000-00005376-00005746": "Do you remember the good old times when you used to play DOS-Games?", "g0NoqnwNCRg-00001-00005796-00006010": "We will help you to bring those feelings back!", "g0NoqnwNCRg-00002-00006080-00006360": "To get your personal 90's gaming experience,", "g0NoqnwNCRg-00003-00006360-00007018": "just connect your DOS-BOX to your TV-Screen or PC-Monitor using the HDMI or VGA-Port.", "g0NoqnwNCRg-00004-00007195-00007406": "Go find your obsolete Keyboard and Mouse,", "g0NoqnwNCRg-00005-00007406-00007670": "plug it in, boot the box and enjoy!", "g0NoqnwNCRg-00006-00007754-00007954": "You can use the internal speaker", "g0NoqnwNCRg-00007-00007954-00008168": "or the 3.5mm jack for audio.", "g0NoqnwNCRg-00008-00009953-00010081": "Hi! My name is Tommy", "g0NoqnwNCRg-00009-00010081-00010187": "I'm Julian.", "g0NoqnwNCRg-00010-00010187-00010317": "And I'm Denis.", "g0NoqnwNCRg-00011-00010334-00010624": "Our idea was to bring back DOS as easy as possible.", "g0NoqnwNCRg-00012-00010624-00010862": "For that reason, we developed the DOS BOX.", "g0NoqnwNCRg-00013-00010862-00011066": "We all love playing DOS-Games", "g0NoqnwNCRg-00014-00011066-00011266": "but we're tired of looking for emulators", "g0NoqnwNCRg-00015-00011266-00011650": "that take too long to get them running or don't work properly.", "g0NoqnwNCRg-00016-00011650-00011850": "Our DOS BOX is Plug'n'Play.", "g0NoqnwNCRg-00017-00011850-00012244": "You can get your games and Software in no time directly from our website.", "g0NoqnwNCRg-00018-00012244-00012560": "They can be installed via USB or SD-Card.", "g0NoqnwNCRg-00019-00012560-00012806": "Support us on indiegogo.com!", "g0NoqnwNCRg-00020-00012806-00013047": "Together we will make this happen!", "g0NoqnwNCRg-00021-00016352-00016466": "YOU CAN EVEN EAT IT!!"}}, {"audio_id": "g1juNrd2XAg", "text": {"g1juNrd2XAg-00000-00000000-00000200": "like"}}, {"audio_id": "g1ezpW1Buxk", "text": {"g1ezpW1Buxk-00000-00000700-00000932": "Hello. In this video we will discuss ...", "g1ezpW1Buxk-00001-00000932-00001204": "the various windows available in MATLAB;", "g1ezpW1Buxk-00002-00001204-00001336": "how to move, resize,", "g1ezpW1Buxk-00003-00001336-00001723": "and undock those windows; and what the windows are used for.", "g1ezpW1Buxk-00004-00001723-00001937": "When you open MATLAB through mySCC,", "g1ezpW1Buxk-00005-00001937-00002171": "you should see a screen similar to this.", "g1ezpW1Buxk-00006-00002171-00002434": "If it looks a little different, don't worry.", "g1ezpW1Buxk-00007-00002434-00002675": "I will show you how to adjust the windows.", "g1ezpW1Buxk-00008-00002676-00002991": "In each of the windows, you may click and drag the ...", "g1ezpW1Buxk-00009-00002991-00003339": "ribbon to move or resize it. A preview appears to show ...", "g1ezpW1Buxk-00010-00003339-00003583": "you where the window will be dropped.", "g1ezpW1Buxk-00011-00003700-00004244": "You may also click and drag the dividing lines to adjust window sizes.", "g1ezpW1Buxk-00012-00004368-00004609": "Further, you may undock and dock as ...", "g1ezpW1Buxk-00013-00004609-00005001": "many windows as you please. Do this by clicking the small ...", "g1ezpW1Buxk-00014-00005001-00005251": "down-arrow in the window's ribbon.", "g1ezpW1Buxk-00015-00005251-00005618": "This allows you to minimize or maximize that window,", "g1ezpW1Buxk-00016-00005618-00005868": "or to hide it behind the main screen.", "g1ezpW1Buxk-00017-00005868-00006259": "You will find what layout works for you with experience.", "g1ezpW1Buxk-00018-00006284-00006561": "To choose one of the standard layouts,", "g1ezpW1Buxk-00019-00006561-00006872": "navigate to the Home tab, Layout dropdown,", "g1ezpW1Buxk-00020-00006872-00007391": "and the select your layout. My personal preference is the Three Column.", "g1ezpW1Buxk-00021-00007528-00007892": "Let's explore what each window is used for.", "g1ezpW1Buxk-00022-00007892-00008337": "The names of each possible window that you will use is ...", "g1ezpW1Buxk-00023-00008337-00008701": "highlighted here for you: Current Folder,", "g1ezpW1Buxk-00024-00008701-00008944": "Command Window, Workspace,", "g1ezpW1Buxk-00025-00008944-00009207": "Variable Editor, Code Editor,", "g1ezpW1Buxk-00026-00009207-00009562": "and Figure Window. Don't be intimidated!", "g1ezpW1Buxk-00027-00009562-00010047": "It is rare indeed that all six of these will be open at once.", "g1ezpW1Buxk-00028-00010088-00010428": "The first thing you should do when opening MATLAB is ...", "g1ezpW1Buxk-00029-00010428-00010784": "connect to your main folder that you are using for this ...", "g1ezpW1Buxk-00030-00010784-00010926": "class. When you do so,", "g1ezpW1Buxk-00031-00010926-00011298": "all your files saved in that folder appear in the Current ...", "g1ezpW1Buxk-00032-00011298-00011551": "Folder window. If you don't see a file,", "g1ezpW1Buxk-00033-00011551-00011891": "you probably won't be able to access it from MATLAB.", "g1ezpW1Buxk-00034-00011892-00012135": "In the center is the Command Window.", "g1ezpW1Buxk-00035-00012135-00012443": "As the name implies, this is where you can type ...", "g1ezpW1Buxk-00036-00012443-00012703": "individual commands to the software.", "g1ezpW1Buxk-00037-00012703-00013019": "Anytime we create a new variable in the Command ...", "g1ezpW1Buxk-00038-00013019-00013295": "Window, it will appear in the Workspace.", "g1ezpW1Buxk-00039-00013400-00013682": "The Workspace is the temporary memory of ...", "g1ezpW1Buxk-00040-00013682-00013930": "MATLAB. It shows what user-defined ...", "g1ezpW1Buxk-00041-00013930-00014179": "variables are known to the program.", "g1ezpW1Buxk-00042-00014179-00014411": "If you see a variable listed here,", "g1ezpW1Buxk-00043-00014411-00014677": "it can be used for later computations.", "g1ezpW1Buxk-00044-00014677-00014950": "If you don't see a variable listed here,", "g1ezpW1Buxk-00045-00014950-00015307": "then MATLAB won't know what to do if you try to use it.", "g1ezpW1Buxk-00046-00015308-00015676": "For example, let's try taco = a + 1.", "g1ezpW1Buxk-00047-00015676-00016097": "a is known to MATLAB to hold the value 7.", "g1ezpW1Buxk-00048-00016097-00016558": "So it will now store 8 as the value for taco.", "g1ezpW1Buxk-00049-00016558-00017084": "But if we try nacho = z + 1, we get an error because z ...", "g1ezpW1Buxk-00050-00017084-00017255": "does not exist.", "g1ezpW1Buxk-00051-00017300-00017538": "Once variables are in memory,", "g1ezpW1Buxk-00052-00017538-00017977": "their contents can be viewed and edited in the variable ...", "g1ezpW1Buxk-00053-00017977-00018254": "Editor. This is helpful for larger ...", "g1ezpW1Buxk-00054-00018254-00018655": "arrays, where we can read them like a spreadsheet.", "g1ezpW1Buxk-00055-00018656-00019089": "When you write code--either a script or a function--you will ...", "g1ezpW1Buxk-00056-00019089-00019327": "see a text editor like you do here.", "g1ezpW1Buxk-00057-00019327-00019744": "Most of your work will done in scripts or functions because ...", "g1ezpW1Buxk-00058-00019744-00020135": "you can save this work and run many lines with one click.", "g1ezpW1Buxk-00059-00020135-00020381": "For example, when I click run here,", "g1ezpW1Buxk-00060-00020381-00020764": "we compute and plot the area of a circle vs. its radius.", "g1ezpW1Buxk-00061-00020764-00021050": "Finally, the Figure Window.", "g1ezpW1Buxk-00062-00021050-00021515": "This will only appear when a figure is created."}}, {"audio_id": "g1IrcaIayB8", "text": {"g1IrcaIayB8-00000-00002358-00002776": "A change in the program for this second half...", "g1IrcaIayB8-00001-00003088-00003372": "I think it's better for the pace...", "g1IrcaIayB8-00002-00003444-00003786": "of this part of the program. I'm gonna start with Fortner.", "g1IrcaIayB8-00003-00003888-00004088": "then continue with Marco", "g1IrcaIayB8-00004-00004164-00004364": "and the rest is the same.", "g1IrcaIayB8-00005-00004434-00004634": "This piece", "g1IrcaIayB8-00006-00004916-00005226": "is the one that I played here in 2002", "g1IrcaIayB8-00007-00005462-00005784": "From the American composer, Jack Fortner", "g1IrcaIayB8-00008-00005854-00006208": "dear friend and highly respected composer", "g1IrcaIayB8-00009-00006282-00006542": "and this is his little homage", "g1IrcaIayB8-00010-00006542-00006692": "to Beethoven", "g1IrcaIayB8-00011-00006692-00006972": "because its called Für Eloísa", "g1IrcaIayB8-00012-00007028-00007495": "therefore, we're gonna hear references", "g1IrcaIayB8-00013-00007542-00008006": "to the infamous bagatelle", "g1IrcaIayB8-00014-00008334-00008534": "that we all know", "g1IrcaIayB8-00015-00008610-00008894": "throughout the whole piece, there are", "g1IrcaIayB8-00016-00008918-00009434": "small references and quotes from that piece", "g1IrcaIayB8-00017-00009434-00009892": "the very composer says this piece is a", "g1IrcaIayB8-00018-00009892-00010214": "marshmallow (Bombón) for the composer from Bonn.", "g1IrcaIayB8-00019-00010214-00010752": "Because Beethoven... Bonn. (Pun: Bombón for the one from Bonn)"}}, {"audio_id": "g2Dafr0ZChk", "text": {"g2Dafr0ZChk-00000-00000010-00000380": "WITH FOOD AT THIS", "g2Dafr0ZChk-00001-00000380-00000387": "WITH FOOD AT THIS", "g2Dafr0ZChk-00002-00000387-00000527": "WITH FOOD AT THIS >> Dennis: CAMP CONFIDENCE OF", "g2Dafr0ZChk-00003-00000527-00000533": "WITH FOOD AT THIS >> Dennis: CAMP CONFIDENCE OF", "g2Dafr0ZChk-00004-00000533-00000727": "WITH FOOD AT THIS >> Dennis: CAMP CONFIDENCE OF  BRAINERD HELD ITS 25th ANNUAL", "g2Dafr0ZChk-00005-00000727-00000734": ">> Dennis: CAMP CONFIDENCE OF  BRAINERD HELD ITS 25th ANNUAL", "g2Dafr0ZChk-00006-00000734-00000927": ">> Dennis: CAMP CONFIDENCE OF  BRAINERD HELD ITS 25th ANNUAL  RIGHT FRIENDS PICNIC MONDAY", "g2Dafr0ZChk-00007-00000927-00000934": "BRAINERD HELD ITS 25th ANNUAL  RIGHT FRIENDS PICNIC MONDAY", "g2Dafr0ZChk-00008-00000934-00001004": "BRAINERD HELD ITS 25th ANNUAL  RIGHT FRIENDS PICNIC MONDAY  AFTERNOON TO CELEBRATE", "g2Dafr0ZChk-00009-00001004-00001011": "RIGHT FRIENDS PICNIC MONDAY  AFTERNOON TO CELEBRATE", "g2Dafr0ZChk-00010-00001011-00001081": "RIGHT FRIENDS PICNIC MONDAY  AFTERNOON TO CELEBRATE  INDEPENDENCE DAY AND THE MEMBERS", "g2Dafr0ZChk-00011-00001081-00001087": "AFTERNOON TO CELEBRATE  INDEPENDENCE DAY AND THE MEMBERS", "g2Dafr0ZChk-00012-00001087-00001184": "AFTERNOON TO CELEBRATE  INDEPENDENCE DAY AND THE MEMBERS OF THE CAMP.", "g2Dafr0ZChk-00013-00001184-00001191": "INDEPENDENCE DAY AND THE MEMBERS OF THE CAMP.", "g2Dafr0ZChk-00014-00001191-00001291": "INDEPENDENCE DAY AND THE MEMBERS OF THE CAMP. CAMP CONFIDENCE LEARNING CENTER", "g2Dafr0ZChk-00015-00001291-00001297": "OF THE CAMP. CAMP CONFIDENCE LEARNING CENTER", "g2Dafr0ZChk-00016-00001297-00001514": "OF THE CAMP. CAMP CONFIDENCE LEARNING CENTER  IS A CAMP FOR PERSONS WITH", "g2Dafr0ZChk-00017-00001514-00001521": "CAMP CONFIDENCE LEARNING CENTER  IS A CAMP FOR PERSONS WITH", "g2Dafr0ZChk-00018-00001521-00001701": "CAMP CONFIDENCE LEARNING CENTER  IS A CAMP FOR PERSONS WITH  DEVELOPMENTAL AND COGNITIVE", "g2Dafr0ZChk-00019-00001701-00001708": "IS A CAMP FOR PERSONS WITH  DEVELOPMENTAL AND COGNITIVE", "g2Dafr0ZChk-00020-00001708-00001928": "IS A CAMP FOR PERSONS WITH  DEVELOPMENTAL AND COGNITIVE  DISABILITIES ALONG WITH THE DEAF", "g2Dafr0ZChk-00021-00001928-00001935": "DEVELOPMENTAL AND COGNITIVE  DISABILITIES ALONG WITH THE DEAF", "g2Dafr0ZChk-00022-00001935-00002048": "DEVELOPMENTAL AND COGNITIVE  DISABILITIES ALONG WITH THE DEAF AND HARD OF HEARING COMMUNITIES.", "g2Dafr0ZChk-00023-00002048-00002055": "DISABILITIES ALONG WITH THE DEAF AND HARD OF HEARING COMMUNITIES.", "g2Dafr0ZChk-00024-00002055-00002275": "DISABILITIES ALONG WITH THE DEAF AND HARD OF HEARING COMMUNITIES. THE CENTER AIMS TO BUILD", "g2Dafr0ZChk-00025-00002275-00002282": "AND HARD OF HEARING COMMUNITIES. THE CENTER AIMS TO BUILD", "g2Dafr0ZChk-00026-00002282-00002412": "AND HARD OF HEARING COMMUNITIES. THE CENTER AIMS TO BUILD  SELF-CONFIDENCE AND SELF-ESTEEM", "g2Dafr0ZChk-00027-00002412-00002419": "THE CENTER AIMS TO BUILD  SELF-CONFIDENCE AND SELF-ESTEEM", "g2Dafr0ZChk-00028-00002419-00002529": "THE CENTER AIMS TO BUILD  SELF-CONFIDENCE AND SELF-ESTEEM  IN THEIR CAMPERS.", "g2Dafr0ZChk-00029-00002529-00002535": "SELF-CONFIDENCE AND SELF-ESTEEM  IN THEIR CAMPERS.", "g2Dafr0ZChk-00030-00002535-00002849": "SELF-CONFIDENCE AND SELF-ESTEEM  IN THEIR CAMPERS. >> OUR CAMPERS HAVE A LOT OF", "g2Dafr0ZChk-00031-00002849-00002856": "IN THEIR CAMPERS. >> OUR CAMPERS HAVE A LOT OF", "g2Dafr0ZChk-00032-00002856-00002942": "IN THEIR CAMPERS. >> OUR CAMPERS HAVE A LOT OF  CHALLENGES, SO THEY NEED SOME", "g2Dafr0ZChk-00033-00002942-00002949": ">> OUR CAMPERS HAVE A LOT OF  CHALLENGES, SO THEY NEED SOME", "g2Dafr0ZChk-00034-00002949-00003056": ">> OUR CAMPERS HAVE A LOT OF  CHALLENGES, SO THEY NEED SOME  HAPPINESS IN THEIR LIVES.", "g2Dafr0ZChk-00035-00003056-00003063": "CHALLENGES, SO THEY NEED SOME  HAPPINESS IN THEIR LIVES.", "g2Dafr0ZChk-00036-00003063-00003239": "CHALLENGES, SO THEY NEED SOME  HAPPINESS IN THEIR LIVES. THEY NEED SOME SOCIALIZATION.", "g2Dafr0ZChk-00037-00003239-00003246": "HAPPINESS IN THEIR LIVES. THEY NEED SOME SOCIALIZATION.", "g2Dafr0ZChk-00038-00003246-00003420": "HAPPINESS IN THEIR LIVES. THEY NEED SOME SOCIALIZATION. THAT'S WHAT THE CAMP PROVIDES.", "g2Dafr0ZChk-00039-00003420-00003426": "THEY NEED SOME SOCIALIZATION. THAT'S WHAT THE CAMP PROVIDES.", "g2Dafr0ZChk-00040-00003426-00003583": "THEY NEED SOME SOCIALIZATION. THAT'S WHAT THE CAMP PROVIDES. GIVES OUR CAMPERS A CHANCE TO BE", "g2Dafr0ZChk-00041-00003583-00003590": "THAT'S WHAT THE CAMP PROVIDES. GIVES OUR CAMPERS A CHANCE TO BE", "g2Dafr0ZChk-00042-00003590-00003767": "THAT'S WHAT THE CAMP PROVIDES. GIVES OUR CAMPERS A CHANCE TO BE SUCCESSFUL AT THEIR OWN LEVEL", "g2Dafr0ZChk-00043-00003767-00003773": "GIVES OUR CAMPERS A CHANCE TO BE SUCCESSFUL AT THEIR OWN LEVEL", "g2Dafr0ZChk-00044-00003773-00004050": "GIVES OUR CAMPERS A CHANCE TO BE SUCCESSFUL AT THEIR OWN LEVEL  BUT ALSO FEEL NORMAL IN OUR", "g2Dafr0ZChk-00045-00004050-00004057": "SUCCESSFUL AT THEIR OWN LEVEL  BUT ALSO FEEL NORMAL IN OUR", "g2Dafr0ZChk-00046-00004057-00004084": "SUCCESSFUL AT THEIR OWN LEVEL  BUT ALSO FEEL NORMAL IN OUR  SOCIETY.", "g2Dafr0ZChk-00047-00004084-00004090": "BUT ALSO FEEL NORMAL IN OUR  SOCIETY.", "g2Dafr0ZChk-00048-00004090-00004200": "BUT ALSO FEEL NORMAL IN OUR  SOCIETY. >> Dennis: THE PICNIC IS PUT ON", "g2Dafr0ZChk-00049-00004200-00004207": "SOCIETY. >> Dennis: THE PICNIC IS PUT ON", "g2Dafr0ZChk-00050-00004207-00004334": "SOCIETY. >> Dennis: THE PICNIC IS PUT ON  EVERY YEAR AND ALLOWS FOR THE", "g2Dafr0ZChk-00051-00004334-00004340": ">> Dennis: THE PICNIC IS PUT ON  EVERY YEAR AND ALLOWS FOR THE", "g2Dafr0ZChk-00052-00004340-00004447": ">> Dennis: THE PICNIC IS PUT ON  EVERY YEAR AND ALLOWS FOR THE  CAMPERS TO COME TOGETHER ALONG", "g2Dafr0ZChk-00053-00004447-00004454": "EVERY YEAR AND ALLOWS FOR THE  CAMPERS TO COME TOGETHER ALONG", "g2Dafr0ZChk-00054-00004454-00004584": "EVERY YEAR AND ALLOWS FOR THE  CAMPERS TO COME TOGETHER ALONG  WITH THEIR FRIENDS AND FAMILY TO", "g2Dafr0ZChk-00055-00004584-00004591": "CAMPERS TO COME TOGETHER ALONG  WITH THEIR FRIENDS AND FAMILY TO", "g2Dafr0ZChk-00056-00004591-00004851": "CAMPERS TO COME TOGETHER ALONG  WITH THEIR FRIENDS AND FAMILY TO PLAY YARD GAMES, GET THEIR FACES", "g2Dafr0ZChk-00057-00004851-00004858": "WITH THEIR FRIENDS AND FAMILY TO PLAY YARD GAMES, GET THEIR FACES", "g2Dafr0ZChk-00058-00004858-00004998": "WITH THEIR FRIENDS AND FAMILY TO PLAY YARD GAMES, GET THEIR FACES PAINTED, AND EVEN TAKE A TURN IN", "g2Dafr0ZChk-00059-00004998-00005004": "PLAY YARD GAMES, GET THEIR FACES PAINTED, AND EVEN TAKE A TURN IN", "g2Dafr0ZChk-00060-00005004-00005945": "PLAY YARD GAMES, GET THEIR FACES PAINTED, AND EVEN TAKE A TURN IN THE DUNK TANK.", "g2Dafr0ZChk-00061-00005945-00005952": "PAINTED, AND EVEN TAKE A TURN IN THE DUNK TANK.", "g2Dafr0ZChk-00062-00005952-00006076": "PAINTED, AND EVEN TAKE A TURN IN THE DUNK TANK. >> THEY ARE LOCALS TO THE", "g2Dafr0ZChk-00063-00006076-00006082": "THE DUNK TANK. >> THEY ARE LOCALS TO THE", "g2Dafr0ZChk-00064-00006082-00006219": "THE DUNK TANK. >> THEY ARE LOCALS TO THE  BRAINERD LAKES AREA.", "g2Dafr0ZChk-00065-00006219-00006226": ">> THEY ARE LOCALS TO THE  BRAINERD LAKES AREA.", "g2Dafr0ZChk-00066-00006226-00006433": ">> THEY ARE LOCALS TO THE  BRAINERD LAKES AREA. HE SPONSORS THIS PICNIC EVERY", "g2Dafr0ZChk-00067-00006433-00006439": "BRAINERD LAKES AREA. HE SPONSORS THIS PICNIC EVERY", "g2Dafr0ZChk-00068-00006439-00006676": "BRAINERD LAKES AREA. HE SPONSORS THIS PICNIC EVERY  YEAR TO SHOWCASE THE ABILITIES"}}, {"audio_id": "g2Dx691SnKg", "text": {"g2Dx691SnKg-00000-00002000-00002208": "Can you hear me I'm calling you", "g2Dx691SnKg-00001-00002220-00002612": "Yes I hear you", "g2Dx691SnKg-00002-00002648-00002900": "For my land do you hear or not?", "g2Dx691SnKg-00003-00002928-00003215": "Make your ears big and come", "g2Dx691SnKg-00004-00003232-00003668": "We are drinking water from the river", "g2Dx691SnKg-00005-00003704-00004176": "Listen to the story", "g2Dx691SnKg-00006-00004200-00004764": "They are shaking their necks and sowing seeds", "g2Dx691SnKg-00007-00004796-00005028": "For my land", "g2Dx691SnKg-00008-00005048-00005492": "Please come and give us a good harvest", "g2Dx691SnKg-00009-00005680-00006631": "From our forefather's time we have eaten betelnut and  done shifting cultivation", "g2Dx691SnKg-00010-00006676-00007216": "And still now we are following our traditional methods", "g2Dx691SnKg-00011-00007316-00008164": "In the future we will still follow our traditional methods", "g2Dx691SnKg-00012-00008164-00008620": "We are farmers and we won't stop these methods", "g2Dx691SnKg-00013-00008620-00008980": "Because there is no other options than this", "g2Dx691SnKg-00014-00009068-00009344": "Has everyone arrived?", "g2Dx691SnKg-00015-00009372-00009616": "Can we start the meeting?", "g2Dx691SnKg-00016-00009724-00010084": "We will start from where the Goera (lightning) struck", "g2Dx691SnKg-00017-00010132-00010268": "Do you all agree?", "g2Dx691SnKg-00018-00010296-00010460": "Yes we agree", "g2Dx691SnKg-00019-00010476-00010900": "Now let's distribute the land", "g2Dx691SnKg-00020-00010960-00011516": "Balsing's land will go to Mansing's mother", "g2Dx691SnKg-00021-00011612-00011904": "Suren's land will be cleaned by Plan's family", "g2Dx691SnKg-00022-00012028-00012352": "Let's go and see the area and clean a bit and have a dream", "g2Dx691SnKg-00023-00012484-00012704": "Let's see the cultivation area", "g2Dx691SnKg-00024-00012912-00013456": "We have been doing shifting cultivation up until now", "g2Dx691SnKg-00025-00013468-00014076": "Our main work is shifting cultivation", "g2Dx691SnKg-00026-00014091-00014836": "We are not only doing shifting cultivation but also our own plantation", "g2Dx691SnKg-00027-00014860-00015360": "And that is why our children are growing up to be smart", "g2Dx691SnKg-00028-00015788-00016332": "We are farmers that specialise in bee keeping", "g2Dx691SnKg-00029-00016356-00016956": "You are doing bee keeping, what benefits do you get for your village?", "g2Dx691SnKg-00030-00016976-00017384": "One thing is  our children,", "g2Dx691SnKg-00031-00017456-00018320": "we can afford school admission and get books for them", "g2Dx691SnKg-00032-00018360-00018900": "Bee keeping supports our needs and we can also afford medicine", "g2Dx691SnKg-00033-00018936-00019508": "We are doing bee keeping for ourselves and to educate our children", "g2Dx691SnKg-00034-00019516-00019884": "As well as improve our lifestyle", "g2Dx691SnKg-00035-00019908-00020276": "Now I am going to show how to squeeze this honey", "g2Dx691SnKg-00036-00020524-00021088": "We live in a hill area", "g2Dx691SnKg-00037-00021100-00021492": "Our main livelyhood is from shifting cultivation", "g2Dx691SnKg-00038-00021508-00022132": "In the fields we cultivate rice and millet", "g2Dx691SnKg-00039-00022180-00022792": "We are supporting our families from the produce of these fields", "g2Dx691SnKg-00040-00022832-00023348": "We are getting our income from shifting cultivation", "g2Dx691SnKg-00041-00023416-00023804": "If we don't do shifting cultivation we won't", "g2Dx691SnKg-00042-00023808-00024200": "be able to survive in these hilly areas", "g2Dx691SnKg-00043-00024236-00024812": "Why is this cultivation a good practice?", "g2Dx691SnKg-00044-00024864-00025692": "Because we don't have any other option", "g2Dx691SnKg-00045-00025700-00026388": "In order to get a years supply of food we have to do shifting cultivation", "g2Dx691SnKg-00046-00026420-00026983": "These days if you do shifting cultivation also", "g2Dx691SnKg-00047-00027108-00027844": "the crops don't grow to their full potential because of the lack of fertiliser", "g2Dx691SnKg-00048-00027860-00028848": "We don't have any other options because of the decrease of natural fertilisers", "g2Dx691SnKg-00049-00028852-00029339": "They are running out", "g2Dx691SnKg-00050-00029352-00030208": "I will explain to you the history of millet varieties", "g2Dx691SnKg-00051-00030220-00030548": "There are two types of millet seeds", "g2Dx691SnKg-00052-00030548-00030883": "Samcheng seeds", "g2Dx691SnKg-00053-00030944-00031804": "We will sow these seeds in the boundary area", "g2Dx691SnKg-00054-00032239-00032960": "Dimrimpa and Dimsimpa's bodies were put in the ground ready to be burnt", "g2Dx691SnKg-00055-00032960-00033560": "The wives went to catch shrimp and prepare food to honour the the two dead men", "g2Dx691SnKg-00056-00033576-00034176": "Tthe dead men then came back to life carrying baskets of Tenarang-Techambil  (citrus fruits) on their backs", "g2Dx691SnKg-00057-00034176-00034720": "The daughters called to their mothers exclaiming their fathers had returned", "g2Dx691SnKg-00058-00034720-00035264": "The daughters names were Rone and Bangme", "g2Dx691SnKg-00059-00035280-00035824": "The wives angrily asked to the daughters 'why did you call me?'", "g2Dx691SnKg-00060-00035824-00036416": "The wives were so sad because of losing their husbands", "g2Dx691SnKg-00061-00036416-00037052": "Because they were so angry they said Rone will drown in the river and Bangme will be killed by a landslide", "g2Dx691SnKg-00062-00037076-00037744": "Meanwhile the wives were still fishing", "g2Dx691SnKg-00063-00037744-00038248": "Dimsimpa and Dimrimpa's bodies put the Tenarang-Techambil near the bedroom", "g2Dx691SnKg-00064-00038248-00038948": "They ran away and dissapeared after that", "g2Dx691SnKg-00065-00038948-00039552": "The wives didn't accept the Tenarang-Techambil but if they did no one would die anymore", "g2Dx691SnKg-00066-00039908-00040232": "Starting during the last week of October", "g2Dx691SnKg-00067-00040312-00041196": "We clean the village, finish our work and", "g2Dx691SnKg-00068-00041264-00041880": "before Wangala festival we spend the whole day cutting banana leaves", "g2Dx691SnKg-00069-00041912-00042416": "Then we clean the banana leaves", "g2Dx691SnKg-00070-00042492-00043108": "In the banana leaves we will cut ginger, garlic and all these things"}}, {"audio_id": "g2PKhpVeVXy", "text": {"g2PKhpVeVXy-00000-00000158-00000818": "Hey, what's goin' on guys?! It is StunningMoney24, or Brenden Wells.", "g2PKhpVeVXy-00001-00000876-00001306": "And... I welcome you back... To another Minecraft video!", "g2PKhpVeVXy-00002-00001352-00001848": "And this time, uh... It's a tutorial! So... Uh...", "g2PKhpVeVXy-00003-00001932-00002492": "I will, uh... Tell you guys more about the... Tutorial of what were're making, uh.", "g2PKhpVeVXy-00004-00002884-00003282": "So... What I'm gonna teach you guys how to make!", "g2PKhpVeVXy-00005-00003336-00003576": "It sounded like (Phone Notification) Uh...", "g2PKhpVeVXy-00006-00003610-00004390": "Stampy's... Lovely house! Yeah, that's right. Stampy's house! Boo yeah! Oh yeah!", "g2PKhpVeVXy-00007-00004548-00005418": "Come on, bounce it out, bounce it out! (Phone Notification) Oh, yeah, so anyway, let's straight.... Into it!", "g2PKhpVeVXy-00008-00005540-00006110": "Uh, if guys didn't know, I did have a tail on my skin!.... And it's pretty awesome!", "g2PKhpVeVXy-00009-00006218-00006614": "Awesome!!... So let's get right into this tutorial.", "g2PKhpVeVXy-00010-00006730-00007948": "First, you guys are going to need, oak wood planks... Uh... Oak wood... Some fences... Uh... There you go, some blue wool!!", "g2PKhpVeVXy-00011-00008078-00009318": "Some sandstone.... Some glass... Uh... Perhaps a... Painting and... Item frame.", "g2PKhpVeVXy-00012-00009460-00009976": "And we'll just grab a chest, uh, or something like that, oh crafting table, that one too! Alright.", "g2PKhpVeVXy-00013-00010060-00010512": "Let's get right into this! First you need your oak wood... Place it down!", "g2PKhpVeVXy-00014-00010584-00011242": "Uh, but I recommend you guys do not, I repeat do not, build this on a, flatland like I am.", "g2PKhpVeVXy-00015-00011290-00011838": "If you- I'm just gonna give a tutorial, so... Eh, eh, eh, so do not do that.", "g2PKhpVeVXy-00016-00011854-00012416": "I- I- It's gonna- Eh, eh, you will not be able to build Stampy's Secret Base at all. So...", "g2PKhpVeVXy-00017-00012526-00013352": "Here we go, we're, um, first you need to add, uh, what is it? Six layers of... Uh... Some fences. One.", "g2PKhpVeVXy-00018-00013494-00014116": "Two... Three... Four... Five.... Six.", "g2PKhpVeVXy-00019-00014184-00014832": "So, you guys should have this so far!... And then... Grab your oak wood itself."}}, {"audio_id": "g3daIRQGNVU", "text": {"g3daIRQGNVU-00000-00002714-00002826": "Lane's that way!", "g3daIRQGNVU-00001-00002970-00003050": "[toot toot]", "g3daIRQGNVU-00002-00003940-00004124": "Hi! You're in the bike lane."}}, {"audio_id": "g3pi0EfBPUy", "text": {"g3pi0EfBPUy-00000-00000029-00000529": "(birds chirping) (water lapping)", "g3pi0EfBPUy-00001-00000794-00000977": "(tranquil piano music)", "g3pi0EfBPUy-00002-00000977-00001094": "- [Matt] It doesn't look like something", "g3pi0EfBPUy-00003-00001094-00001279": "that should be in fresh water.", "g3pi0EfBPUy-00004-00001279-00001585": "It looks like a cross between a swordfish", "g3pi0EfBPUy-00005-00001585-00001668": "and uh", "g3pi0EfBPUy-00006-00001668-00001773": "a trout.", "g3pi0EfBPUy-00007-00001773-00001971": "And then you see this thing that's iridescent", "g3pi0EfBPUy-00008-00001971-00002112": "and shining the way it does", "g3pi0EfBPUy-00009-00002112-00002353": "and it just makes you look at everything around you", "g3pi0EfBPUy-00010-00002353-00002515": "in a different way.", "g3pi0EfBPUy-00011-00002515-00002624": "- [Jeff] If you were to come across a Grayling", "g3pi0EfBPUy-00012-00002624-00002707": "for the first time", "g3pi0EfBPUy-00013-00002707-00002790": "and look at that", "g3pi0EfBPUy-00014-00002790-00002873": "and if you look at that dorsal fin", "g3pi0EfBPUy-00015-00002873-00003090": "it's like nothing you've ever seen before.", "g3pi0EfBPUy-00016-00003090-00003261": "They're part and parcel of the experience", "g3pi0EfBPUy-00017-00003261-00003379": "of the Centennial Valley.", "g3pi0EfBPUy-00018-00003379-00003645": "So if we lost them we'd be losing part of the valley.", "g3pi0EfBPUy-00019-00004291-00004699": "(soaring piano and violin music)", "g3pi0EfBPUy-00020-00005614-00005896": "- I came here in the fall of 2008.", "g3pi0EfBPUy-00021-00006011-00006254": "And the staff had been writing", "g3pi0EfBPUy-00022-00006254-00006517": "a comprehensive conservation plan.", "g3pi0EfBPUy-00023-00006517-00006756": "Part of what was in that plan was to", "g3pi0EfBPUy-00024-00006756-00007041": "add Arctic Grayling conservation", "g3pi0EfBPUy-00025-00007041-00007280": "at a level that it hadn't been in the past.", "g3pi0EfBPUy-00026-00007511-00007604": "- In the lower 48", "g3pi0EfBPUy-00027-00007604-00007828": "there were only two Arctic Grayling populations", "g3pi0EfBPUy-00028-00007828-00007976": "after the last glaciation.", "g3pi0EfBPUy-00029-00007976-00008059": "One was in Michigan", "g3pi0EfBPUy-00030-00008059-00008196": "that one's extinct.", "g3pi0EfBPUy-00031-00008196-00008391": "And one was in the upper headwaters", "g3pi0EfBPUy-00032-00008391-00008499": "of the Missouri River.", "g3pi0EfBPUy-00033-00008499-00008696": "So those remnant populations", "g3pi0EfBPUy-00034-00008696-00008922": "are glacial relic populations", "g3pi0EfBPUy-00035-00008922-00009230": "which means that they were separated from Grayling", "g3pi0EfBPUy-00036-00009230-00009441": "that exists in the northern latitudes.", "g3pi0EfBPUy-00037-00011264-00011467": "- Grayling in Montana had been petitioned", "g3pi0EfBPUy-00038-00011467-00011724": "to be listed under the Endangered Species Act", "g3pi0EfBPUy-00039-00011724-00011904": "so that sort of uncertainty", "g3pi0EfBPUy-00040-00011904-00012088": "loomed over everything.", "g3pi0EfBPUy-00041-00012364-00012552": "- The animosity between agencies was", "g3pi0EfBPUy-00042-00012638-00012729": "high.", "g3pi0EfBPUy-00043-00012729-00012900": "There was tremendous disagreement", "g3pi0EfBPUy-00044-00012900-00013087": "on what was driving the Grayling population", "g3pi0EfBPUy-00045-00013087-00013245": "and how best to fix it.", "g3pi0EfBPUy-00046-00013804-00014121": "(upbeat guitar music)", "g3pi0EfBPUy-00047-00014366-00014577": "- We sat down and talked about", "g3pi0EfBPUy-00048-00014577-00014756": "what we wanted to do", "g3pi0EfBPUy-00049-00014756-00014922": "as individual agencies", "g3pi0EfBPUy-00050-00014922-00015194": "to start to better conserve grayling.", "g3pi0EfBPUy-00051-00015194-00015382": "What became apparent really quickly", "g3pi0EfBPUy-00052-00015382-00015541": "is we were in the same camps", "g3pi0EfBPUy-00053-00015541-00015762": "that people were in 40 years ago.", "g3pi0EfBPUy-00054-00015762-00016037": "We sort of took a step back and said", "g3pi0EfBPUy-00055-00016037-00016341": "rather than debating about these individual ideas", "g3pi0EfBPUy-00056-00016341-00016499": "let's test them all.", "g3pi0EfBPUy-00057-00016499-00016632": "We'll let grayling", "g3pi0EfBPUy-00058-00016632-00016784": "and their population response", "g3pi0EfBPUy-00059-00016784-00017206": "decide which is the best management approach going forward.", "g3pi0EfBPUy-00060-00017206-00017304": "- Over the 80 years", "g3pi0EfBPUy-00061-00017304-00017529": "three hypotheses kept being put forward.", "g3pi0EfBPUy-00062-00017742-00017990": "- We thought Grayling numbers were being challenged", "g3pi0EfBPUy-00063-00017990-00018441": "by competition from hybrid cutthroat rainbow trout.", "g3pi0EfBPUy-00064-00018530-00018703": "- Another limiting factor", "g3pi0EfBPUy-00065-00018703-00018986": "was spawning habitat in the streams.", "g3pi0EfBPUy-00066-00018986-00019254": "Whether it was because of land use", "g3pi0EfBPUy-00067-00019254-00019480": "or natural factors", "g3pi0EfBPUy-00068-00019480-00019702": "Grayling may not have adequate amounts", "g3pi0EfBPUy-00069-00019702-00019945": "or high enough quality spawning habitat.", "g3pi0EfBPUy-00070-00020172-00020460": "- Another leading idea was winter habitat.", "g3pi0EfBPUy-00071-00020460-00020754": "These fish migrate up streams to spawn", "g3pi0EfBPUy-00072-00020754-00021076": "and migrate back to Upper Red Rock Lake to winter.", "g3pi0EfBPUy-00073-00021076-00021437": "It's a large natural lake but it's shallow", "g3pi0EfBPUy-00074-00021437-00021682": "and so when you have a hard winter", "g3pi0EfBPUy-00075-00021682-00022033": "you can have anoxic low-oxygen conditions", "g3pi0EfBPUy-00076-00022033-00022182": "and the fish die.", "g3pi0EfBPUy-00077-00022182-00022389": "- There was information that both supported", "g3pi0EfBPUy-00078-00022389-00022586": "and refuted each idea.", "g3pi0EfBPUy-00079-00022586-00022860": "- We had an idea of how we could test those concurrently.", "g3pi0EfBPUy-00080-00022860-00023107": "And that would just take all of us to get it done.", "g3pi0EfBPUy-00081-00023270-00023420": "(determined upbeat country music)", "g3pi0EfBPUy-00082-00023420-00023802": "- The adaptive management plan is really just a way", "g3pi0EfBPUy-00083-00023802-00024058": "to test different management alternatives.", "g3pi0EfBPUy-00084-00024058-00024285": "That's it in its simplest form.", "g3pi0EfBPUy-00085-00024518-00024761": "They're described in different ways", "g3pi0EfBPUy-00086-00024761-00024866": "hypotheses", "g3pi0EfBPUy-00087-00024966-00025098": "limiting factors.", "g3pi0EfBPUy-00088-00025441-00025574": "But at the end of the day", "g3pi0EfBPUy-00089-00025574-00025791": "we're just sequentially implementing", "g3pi0EfBPUy-00090-00025791-00025941": "different management actions", "g3pi0EfBPUy-00091-00025941-00026145": "looking at the population response", "g3pi0EfBPUy-00092-00026145-00026362": "and then implementing other management actions", "g3pi0EfBPUy-00093-00026362-00026683": "to ultimately decide how we can most effectively manage.", "g3pi0EfBPUy-00094-00026973-00027304": "- Adaptive management ultimately is agreeing to disagree", "g3pi0EfBPUy-00095-00027304-00027445": "and being willing", "g3pi0EfBPUy-00096-00027445-00027579": "to test", "g3pi0EfBPUy-00097-00027579-00027752": "competing ideas at the same time", "g3pi0EfBPUy-00098-00027752-00027889": "with the same project.", "g3pi0EfBPUy-00099-00027889-00028086": "- The rest of us just tried to help", "g3pi0EfBPUy-00100-00028086-00028252": "in any way we could.", "g3pi0EfBPUy-00101-00028252-00028435": "But when they get into the deep mathematics", "g3pi0EfBPUy-00102-00028435-00028682": "it's gotta go back to Jeff and Matt.", "g3pi0EfBPUy-00103-00028855-00028938": "- Matt and I", "g3pi0EfBPUy-00104-00028938-00029049": "literally spent a week", "g3pi0EfBPUy-00105-00029049-00029167": "for each model.", "g3pi0EfBPUy-00106-00029167-00029293": "We had to go through that process", "g3pi0EfBPUy-00107-00029293-00029536": "of thinking about the mechanisms", "g3pi0EfBPUy-00108-00029536-00029833": "that were behind those hypotheses", "g3pi0EfBPUy-00109-00029833-00029939": "collect the data", "g3pi0EfBPUy-00110-00029939-00030044": "the biological information", "g3pi0EfBPUy-00111-00030044-00030247": "all the historical information.", "g3pi0EfBPUy-00112-00030247-00030389": "And then building a model", "g3pi0EfBPUy-00113-00030389-00030652": "that could take the data we collected", "g3pi0EfBPUy-00114-00030652-00030795": "and spit out a prediction.", "g3pi0EfBPUy-00115-00030795-00030906": "- We then compare", "g3pi0EfBPUy-00116-00030906-00031048": "the number of Grayling that showed up", "g3pi0EfBPUy-00117-00031048-00031211": "to each model's prediction", "g3pi0EfBPUy-00118-00031211-00031383": "to understand which one", "g3pi0EfBPUy-00119-00031383-00031706": "is probably most accurately influencing grayling.", "g3pi0EfBPUy-00120-00032584-00032926": "(uplifting guitar music)", "g3pi0EfBPUy-00121-00033087-00033217": "- For cutthroat trout", "g3pi0EfBPUy-00122-00033217-00033330": "what we wanted to do", "g3pi0EfBPUy-00123-00033330-00033602": "was see how many grayling would be in the population", "g3pi0EfBPUy-00124-00033602-00033771": "at a high level of cutthroat trout", "g3pi0EfBPUy-00125-00033771-00033922": "but also kind of a medium", "g3pi0EfBPUy-00126-00033922-00034046": "and a low level.", "g3pi0EfBPUy-00127-00034046-00034169": "And in order to do that", "g3pi0EfBPUy-00128-00034169-00034263": "we needed to", "g3pi0EfBPUy-00129-00034263-00034545": "to suppress a population in a short amount of time.", "g3pi0EfBPUy-00130-00034635-00034881": "What we did was set up a weir", "g3pi0EfBPUy-00131-00034881-00035094": "and culled fish from the population", "g3pi0EfBPUy-00132-00035094-00035372": "as they came up during the spawning run.", "g3pi0EfBPUy-00133-00035372-00035545": "We also called on the anglers.", "g3pi0EfBPUy-00134-00035892-00036007": "- By the second year", "g3pi0EfBPUy-00135-00036007-00036139": "the word was out.", "g3pi0EfBPUy-00136-00036139-00036312": "We went from one or two vehicles", "g3pi0EfBPUy-00137-00036312-00036515": "to 30 vehicles parked in one place", "g3pi0EfBPUy-00138-00036515-00036679": "and three people per vehicle.", "g3pi0EfBPUy-00139-00037171-00037254": "And", "g3pi0EfBPUy-00140-00037254-00037588": "potentially everybody coming back with 10 or 20 fish", "g3pi0EfBPUy-00141-00037588-00037742": "all of which are over 3 pound.", "g3pi0EfBPUy-00142-00038255-00038455": "People had a lot of fun.", "g3pi0EfBPUy-00143-00038655-00038815": "- Things were going along nicely.", "g3pi0EfBPUy-00144-00038815-00039050": "We were reducing the number of cutthroat trout.", "g3pi0EfBPUy-00145-00039237-00039410": "We were collecting really good data.", "g3pi0EfBPUy-00146-00039410-00039711": "But we weren't just collecting data for cutthroat trout.", "g3pi0EfBPUy-00147-00039711-00040030": "We concurrently collect data for all of our hypotheses.", "g3pi0EfBPUy-00148-00040227-00040441": "(lively guitar music)", "g3pi0EfBPUy-00149-00040441-00040573": "- The second test", "g3pi0EfBPUy-00150-00040573-00040784": "was to start looking at whether or not", "g3pi0EfBPUy-00151-00040784-00040930": "the fish have access", "g3pi0EfBPUy-00152-00040930-00041200": "to adequate amounts of stream habitat.", "g3pi0EfBPUy-00153-00041422-00041515": "- What we did", "g3pi0EfBPUy-00154-00041515-00041876": "was take advantage of a natural fragmenter of habitat", "g3pi0EfBPUy-00155-00041876-00041959": "beavers.", "g3pi0EfBPUy-00156-00043404-00043710": "They had built over 50 dams in Red Rock Creek", "g3pi0EfBPUy-00157-00043710-00044075": "and essentially made habitat that was upstream of those", "g3pi0EfBPUy-00158-00044075-00044244": "unavailable to fish.", "g3pi0EfBPUy-00159-00044244-00044386": "We notched those dams", "g3pi0EfBPUy-00160-00044386-00044529": "in the course of a year", "g3pi0EfBPUy-00161-00044529-00044706": "in order to make many many many", "g3pi0EfBPUy-00162-00044706-00044789": "more", "g3pi0EfBPUy-00163-00044789-00044971": "meters of habitat available to fish.", "g3pi0EfBPUy-00164-00045810-00046143": "(exciting violin music)", "g3pi0EfBPUy-00165-00047013-00047132": "- There's no way I could help", "g3pi0EfBPUy-00166-00047132-00047230": "those two guys", "g3pi0EfBPUy-00167-00047230-00047500": "with the mathematics or the models.", "g3pi0EfBPUy-00168-00047500-00047774": "But I have a keen interest in history.", "g3pi0EfBPUy-00169-00048100-00048356": "Some of the stuff in archival information", "g3pi0EfBPUy-00170-00048356-00048583": "really got me to thinking", "g3pi0EfBPUy-00171-00048583-00048879": "that that story hadn't been fully fleshed out.", "g3pi0EfBPUy-00172-00049050-00049274": "Six anglers caught fully", "g3pi0EfBPUy-00173-00049274-00049488": "1,000 Grayling in one day.", "g3pi0EfBPUy-00174-00049746-00049896": "We determined", "g3pi0EfBPUy-00175-00049896-00050324": "that the route the fish had taken to get to that springhead", "g3pi0EfBPUy-00176-00050324-00050644": "had been altered by duck hunters in 1908.", "g3pi0EfBPUy-00177-00050762-00050970": "And we had seen in Google Earth", "g3pi0EfBPUy-00178-00050970-00051084": "photos", "g3pi0EfBPUy-00179-00051084-00051433": "areas of a very curvy sinuous river", "g3pi0EfBPUy-00180-00051433-00051678": "just going straight as an arrow.", "g3pi0EfBPUy-00181-00051678-00051874": "It seemed odd.", "g3pi0EfBPUy-00182-00051874-00052166": "Maybe we just needed to figure out how to put the landscape", "g3pi0EfBPUy-00183-00052166-00052460": "back to the way it was in the late 1800s.", "g3pi0EfBPUy-00184-00052564-00052814": "Our colleagues who were explosives experts", "g3pi0EfBPUy-00185-00052814-00052989": "had it all put together.", "g3pi0EfBPUy-00186-00052989-00053091": "And then", "g3pi0EfBPUy-00187-00053091-00053244": "time came.", "g3pi0EfBPUy-00188-00053244-00053369": "And it was four", "g3pi0EfBPUy-00189-00053369-00053452": "three", "g3pi0EfBPUy-00190-00053452-00053535": "two", "g3pi0EfBPUy-00191-00053535-00053680": "one", "g3pi0EfBPUy-00192-00053680-00054013": "(explosives detonating)", "g3pi0EfBPUy-00193-00054490-00054616": "Almost immediately", "g3pi0EfBPUy-00194-00054616-00054897": "the stream reconnected to the historic channel", "g3pi0EfBPUy-00195-00054897-00055090": "and left the channel", "g3pi0EfBPUy-00196-00055090-00055313": "that had been created by the duck hunters", "g3pi0EfBPUy-00197-00055313-00055428": "a hundred years before.", "g3pi0EfBPUy-00198-00055851-00056240": "There was a lot of happiness that the project had gone well.", "g3pi0EfBPUy-00199-00056240-00056565": "But until the fish told us it was a success", "g3pi0EfBPUy-00200-00056565-00056776": "it really wasn't a success", "g3pi0EfBPUy-00201-00056776-00057034": "it was just a story about an explosion.", "g3pi0EfBPUy-00202-00057401-00057901": "(ethereal violin music) (light rain falling)", "g3pi0EfBPUy-00203-00058435-00058611": "- Going into the winter of 2015/16", "g3pi0EfBPUy-00204-00058611-00058799": "we had had", "g3pi0EfBPUy-00205-00058799-00059063": "four years of cutthroat removal at that point.", "g3pi0EfBPUy-00206-00059325-00059541": "So the competition model was predicting", "g3pi0EfBPUy-00207-00059541-00059690": "fantastic spawning run", "g3pi0EfBPUy-00208-00059690-00059942": "coming in 2016 for Grayling.", "g3pi0EfBPUy-00209-00059942-00060135": "But the winter habitat model predicted", "g3pi0EfBPUy-00210-00060135-00060285": "a population crash.", "g3pi0EfBPUy-00211-00060833-00061232": "- I actually remember real specifically in 2016.", "g3pi0EfBPUy-00212-00061232-00061419": "It was a cold wet day.", "g3pi0EfBPUy-00213-00061522-00061896": "Matt Jaeger was there to do his surveys.", "g3pi0EfBPUy-00214-00061896-00062189": "We had expected the Grayling to be there by then", "g3pi0EfBPUy-00215-00062189-00062391": "we had not caught many in the trap.", "g3pi0EfBPUy-00216-00062391-00062760": "And his surveys didn't find many grayling fish either.", "g3pi0EfBPUy-00217-00062975-00063101": "- It was really what", "g3pi0EfBPUy-00218-00063101-00063246": "winter habitat model predicted.", "g3pi0EfBPUy-00219-00063246-00063620": "Our grayling population had declined fivefold.", "g3pi0EfBPUy-00220-00063620-00063810": "- And that was hard to take.", "g3pi0EfBPUy-00221-00063946-00064192": "- The bad winter and population decline were", "g3pi0EfBPUy-00222-00064192-00064433": "undeniably a bad thing for Grayling.", "g3pi0EfBPUy-00223-00064433-00064653": "But they were a great great thing for learning.", "g3pi0EfBPUy-00224-00064653-00064866": "I think that was one of the first times", "g3pi0EfBPUy-00225-00064866-00065066": "that Jeff and I looked at each other and said", "g3pi0EfBPUy-00226-00065066-00065245": "\"Holy smokes this is gonna work.\"", "g3pi0EfBPUy-00227-00065397-00065484": "- Learning that", "g3pi0EfBPUy-00228-00065484-00065584": "winter habitat", "g3pi0EfBPUy-00229-00065584-00065724": "may be the limiting factor", "g3pi0EfBPUy-00230-00065724-00065867": "is in a lot of ways positive.", "g3pi0EfBPUy-00231-00065867-00066194": "It helps us understand what we need to do moving forward", "g3pi0EfBPUy-00232-00066194-00066414": "to ensure that Grayling stay in this valley.", "g3pi0EfBPUy-00233-00066814-00067106": "(serene piano music)", "g3pi0EfBPUy-00234-00067106-00067335": "- As the Project Leader of a national wildlife refuge.", "g3pi0EfBPUy-00235-00067335-00067608": "My job is to try to conserve", "g3pi0EfBPUy-00236-00067608-00067795": "the wildlife that are native here", "g3pi0EfBPUy-00237-00067795-00068083": "and try to recover those that are struggling", "g3pi0EfBPUy-00238-00068171-00068473": "and lead the staff to figure out how to do that best.", "g3pi0EfBPUy-00239-00069079-00069306": "I was just in my office", "g3pi0EfBPUy-00240-00069306-00069655": "and I got a text from Jason", "g3pi0EfBPUy-00241-00069655-00069859": "and he had a picture connected to it.", "g3pi0EfBPUy-00242-00069958-00070041": "- There's one", "g3pi0EfBPUy-00243-00070217-00070349": "- Yeah! (others exclaiming)", "g3pi0EfBPUy-00244-00070349-00070472": "- Age one Grayling", "g3pi0EfBPUy-00245-00070642-00070917": "- He explained that they had caught a Grayling", "g3pi0EfBPUy-00246-00070917-00071118": "in the springhead", "g3pi0EfBPUy-00247-00071118-00071258": "and this was him.", "g3pi0EfBPUy-00248-00071587-00071737": "It actually took me a little bit", "g3pi0EfBPUy-00249-00071737-00071943": "to really understand.", "g3pi0EfBPUy-00250-00071943-00072059": "This is what we'd been", "g3pi0EfBPUy-00251-00072059-00072142": "looking for.", "g3pi0EfBPUy-00252-00072142-00072288": "This is what we were hoping for.", "g3pi0EfBPUy-00253-00072288-00072391": "And", "g3pi0EfBPUy-00254-00072391-00072571": "this hadn't happened in a long time.", "g3pi0EfBPUy-00255-00075452-00075610": "This adaptive management", "g3pi0EfBPUy-00256-00075610-00075818": "has brought to the table", "g3pi0EfBPUy-00257-00075818-00075966": "history", "g3pi0EfBPUy-00258-00075966-00076115": "science", "g3pi0EfBPUy-00259-00076115-00076284": "on-the-ground management", "g3pi0EfBPUy-00260-00076284-00076483": "different agencies", "g3pi0EfBPUy-00261-00076483-00076725": "and problem-solving at a level", "g3pi0EfBPUy-00262-00076725-00076996": "that transcends careers.", "g3pi0EfBPUy-00263-00077190-00077518": "I think the future for Grayling here is bright", "g3pi0EfBPUy-00264-00077518-00077774": "because we're on the right track.", "g3pi0EfBPUy-00265-00077774-00077936": "We're looking at all aspects", "g3pi0EfBPUy-00266-00077936-00078138": "we have all these hypotheses", "g3pi0EfBPUy-00267-00078138-00078263": "and these models.", "g3pi0EfBPUy-00268-00078263-00078579": "1,000 grayling coming up Red Rock Creek", "g3pi0EfBPUy-00269-00078579-00078755": "will some day not just be a goal", "g3pi0EfBPUy-00270-00078755-00078955": "it'll be something we can accomplish", "g3pi0EfBPUy-00271-00078955-00079178": "with relative confidence each year."}}, {"audio_id": "g3D1xTskTzY", "text": {"g3D1xTskTzY-00000-00000120-00000635": "- We have to know one lateral rotator of the however", "g3D1xTskTzY-00001-00000637-00000943": "billion number of lateral rotators there are.", "g3D1xTskTzY-00002-00000945-00001281": "We are going to go look at multiple lateral rotators", "g3D1xTskTzY-00003-00001283-00001435": "and hopefully you'll be like,", "g3D1xTskTzY-00004-00001437-00001739": "yep, I know the one we have to know.", "g3D1xTskTzY-00005-00001741-00002197": "What is the action of the lateral rotators?", "g3D1xTskTzY-00006-00002199-00002731": "We laterally rotate the thigh.", "g3D1xTskTzY-00007-00002733-00002935": "Now, think about that for a second.", "g3D1xTskTzY-00008-00002937-00003076": "Before I tell you anything else,", "g3D1xTskTzY-00009-00003079-00003451": "where are you going to expect to find this guy?", "g3D1xTskTzY-00010-00003454-00003843": "Well, we have one attachment on a lateral rotator.", "g3D1xTskTzY-00011-00003845-00004297": "They almost all attach somewhere on the sacrum.", "g3D1xTskTzY-00012-00004300-00004460": "And I'm going to tell you that", "g3D1xTskTzY-00013-00004462-00004885": "to enable lateral rotation they kind of attach this one,", "g3D1xTskTzY-00014-00004887-00005097": "piriformis attaches to the anterior", "g3D1xTskTzY-00015-00005100-00005405": "aspect of the sacrum, and we'll go look at that.", "g3D1xTskTzY-00016-00005408-00005635": "The other attachment has to be--", "g3D1xTskTzY-00017-00005637-00005897": "if we are laterally rotating the thigh,", "g3D1xTskTzY-00018-00005900-00006197": "what bone are we going to attach to?", "g3D1xTskTzY-00019-00006199-00006897": "You know we are going to attach to the greater trochanter.", "g3D1xTskTzY-00020-00006899-00007322": "Boom. Now, let's go check this guy out.", "g3D1xTskTzY-00021-00007325-00007581": "Right-- oh, see all of that.", "g3D1xTskTzY-00022-00007583-00007943": "Don't you see piriformis in there? No.", "g3D1xTskTzY-00023-00007945-00008301": "Piriformis is hidden by gluteus maximus first.", "g3D1xTskTzY-00024-00008304-00008497": "Get it out of the way. Peek-a-boo.", "g3D1xTskTzY-00025-00008499-00008739": "Look. You can kind of see where it is.", "g3D1xTskTzY-00026-00008741-00009097": "Those look like lateral rotators to me.", "g3D1xTskTzY-00027-00009100-00009218": "Bye-bye. Look.", "g3D1xTskTzY-00028-00009220-00009456": "Right there is piriformis.", "g3D1xTskTzY-00029-00009458-00009618": "And I think we have to get rid of some other stuff", "g3D1xTskTzY-00030-00009620-00009910": "before it will label it for us.", "g3D1xTskTzY-00031-00009912-00010097": "Let's get rid of a whole bunch of other stuff", "g3D1xTskTzY-00032-00010099-00010272": "just so we don't get distracted.", "g3D1xTskTzY-00033-00010275-00010568": "Oops. Not that much stuff.", "g3D1xTskTzY-00034-00010570-00010760": "You can see that we are attaching to the sacrum,", "g3D1xTskTzY-00035-00010762-00010897": "and you can see that we are attaching", "g3D1xTskTzY-00036-00010899-00011047": "to the greater trochanter.", "g3D1xTskTzY-00037-00011050-00011376": "You can imagine if we attach to the interior", "g3D1xTskTzY-00038-00011379-00011697": "side of the sacrum you can totally visualize how lateral", "g3D1xTskTzY-00039-00011699-00012072": "rotation is going to take place.", "g3D1xTskTzY-00040-00012075-00012297": "Piriformis is an interesting one", "g3D1xTskTzY-00041-00012299-00012739": "and is clinically significant because it snuggles next to", "g3D1xTskTzY-00042-00012741-00013239": "all of these other lateral rotators and the muscle--", "g3D1xTskTzY-00043-00013241-00013576": "excuse me-- the nerve that comes down,", "g3D1xTskTzY-00044-00013579-00014064": "it, like, comes between piriformis and these", "g3D1xTskTzY-00045-00014066-00014414": "other lateral rotators, is the sciatic nerve.", "g3D1xTskTzY-00046-00014416-00014597": "And so if you have piriformis issues,", "g3D1xTskTzY-00047-00014599-00014739": "your piriformis gets tight,", "g3D1xTskTzY-00048-00014741-00015143": "it will squish down on your sciatic nerve and cause", "g3D1xTskTzY-00049-00015145-00015356": "the condition known as sciatica,", "g3D1xTskTzY-00050-00015358-00015681": "which is just a pissed off sciatic nerve.", "g3D1xTskTzY-00051-00015683-00016222": "When we looked at our bodies I am shocked at the size", "g3D1xTskTzY-00052-00016225-00016397": "of the sciatic nerve. It is--", "g3D1xTskTzY-00053-00016399-00016556": "it's huge. It's, like, the size of a pencil.", "g3D1xTskTzY-00054-00016558-00016826": "I mean, it's like-- it's ridiculous.", "g3D1xTskTzY-00055-00016829-00016997": "And it innervates.", "g3D1xTskTzY-00056-00016999-00017285": "It's responsible for your whole leg.", "g3D1xTskTzY-00057-00017287-00017581": "So I guess it makes sense that it should be really gigantic,", "g3D1xTskTzY-00058-00017583-00017760": "but there's going to be some", "g3D1xTskTzY-00059-00017762-00018143": "serious consequences if you are squishing it.", "g3D1xTskTzY-00060-00018145-00018560": "So you can imagine to massage something like", "g3D1xTskTzY-00061-00018562-00018805": "that you've got to do the magic of going through,", "g3D1xTskTzY-00062-00018808-00018993": "holy crap, all of that stuff.", "g3D1xTskTzY-00063-00018995-00019139": "Yeah. So that's a real fun", "g3D1xTskTzY-00064-00019141-00019597": "experience if you are having your piriformis worked on.", "g3D1xTskTzY-00065-00019599-00019905": "Hum, how that is for a nice quickie one?", "g3D1xTskTzY-00066-00019908-00020185": "We've got three foot movers.", "g3D1xTskTzY-00067-00020187-00020397": "Count them. Three.", "g3D1xTskTzY-00068-00020399-00020699": "I'll be right back to move your foot."}}, {"audio_id": "g3LxYBZMpcY", "text": {"g3LxYBZMpcY-00000-00000021-00000537": "This video will help you start using the Insight online learning system at City College.", "g3LxYBZMpcY-00001-00000537-00001061": "Any courses the are online, or partially online like a hybrid, or a tech-enhanced course with", "g3LxYBZMpcY-00002-00001061-00001554": "an Insight page will be similar, so once you get the basics down, you'll be able to apply", "g3LxYBZMpcY-00003-00001554-00002134": "the same principles throughout with any course that uses the Insight system.", "g3LxYBZMpcY-00004-00002134-00003204": "Open your web browser (such as Internet Explorer or Mozilla Firefox) and go to http://insight.ccsf.edu.", "g3LxYBZMpcY-00005-00003204-00003875": "It is a good idea to bookmark this page so that it is easy for you to login and participate", "g3LxYBZMpcY-00006-00003875-00004189": "often in your Insight course.", "g3LxYBZMpcY-00007-00004189-00004598": "You'll need to set aside some time in your schedule to work on your assignments, just", "g3LxYBZMpcY-00008-00004598-00005107": "as you would have to set aside time to come to a traditional classroom.", "g3LxYBZMpcY-00009-00005107-00005619": "You can decide what days and times work best for you, but I suggest that you set aside", "g3LxYBZMpcY-00010-00005619-00005976": "regular times that you are available during each week.", "g3LxYBZMpcY-00011-00005976-00006450": "I suggest you don't wait until the weekend to get started - as you may need to contact", "g3LxYBZMpcY-00012-00006450-00006927": "your instructor to ask for clarification or help.", "g3LxYBZMpcY-00013-00006927-00007279": "You should have already received an email with your login information.", "g3LxYBZMpcY-00014-00007279-00007750": "If you are having trouble logging in, please contact your instructor.", "g3LxYBZMpcY-00015-00007750-00008309": "After you login to Insight, you'll see any courses you are enrolled in appear here, in", "g3LxYBZMpcY-00016-00008309-00008702": "the My Courses area on the left of the window.", "g3LxYBZMpcY-00017-00008702-00009186": "Click the course title and you'll see the main course homepage.", "g3LxYBZMpcY-00018-00009186-00009568": "You'll notice that the window is divided into three areas.", "g3LxYBZMpcY-00019-00009568-00010079": "There are two small side columns, one on the left and one on the right of the page.", "g3LxYBZMpcY-00020-00010079-00010445": "We'll get into these a little more later on.", "g3LxYBZMpcY-00021-00010445-00010878": "The main place to look is the center area of the course homepage.", "g3LxYBZMpcY-00022-00010878-00011257": "Most of what you'll need is found right here in the middle of the page.", "g3LxYBZMpcY-00023-00011257-00011785": "What you see now are the top block (block 0) that has general information about the", "g3LxYBZMpcY-00024-00011785-00012325": "class - including the syllabus - and below it the first week of content.", "g3LxYBZMpcY-00025-00012325-00012858": "To open any of these resources from the homepage, just click the link.", "g3LxYBZMpcY-00026-00012858-00013347": "This course homepage will grow longer over the semester as more weeks of content become", "g3LxYBZMpcY-00027-00013347-00013527": "visible to you.", "g3LxYBZMpcY-00028-00013527-00013997": "Each Monday morning new content and assignments will appear at the bottom of the page, so", "g3LxYBZMpcY-00029-00013997-00014578": "that by the end of the class you will have one long page with several weeks of content.", "g3LxYBZMpcY-00030-00014578-00014969": "You'll notice just below the Syllabus link are two Forum links.", "g3LxYBZMpcY-00031-00014969-00015538": "I know these are discussion forums because of this icon before the title.", "g3LxYBZMpcY-00032-00015538-00016003": "Forums are a place you can type a question, and everyone in the class both sees the question,", "g3LxYBZMpcY-00033-00016003-00016337": "and responds to it by replying.", "g3LxYBZMpcY-00034-00016337-00016858": "So we'll use them not only as a place for you to Post Your Questions, but also to virtually", "g3LxYBZMpcY-00035-00016858-00017287": "meet each other, and to complete course assignments.", "g3LxYBZMpcY-00036-00017287-00017904": "The Messages from Instructor forum is a \"read-only\" forum -- where only your instructor can post", "g3LxYBZMpcY-00037-00017904-00018230": "messages for the entire class to read.", "g3LxYBZMpcY-00038-00018230-00018806": "You can think of this as an Announcement area - and messages posted here will also be emailed", "g3LxYBZMpcY-00039-00018806-00018945": "to you.", "g3LxYBZMpcY-00040-00018945-00019447": "The message may appear in your email as just a link, letting you know that a new announcement", "g3LxYBZMpcY-00041-00019447-00019636": "has been posted.", "g3LxYBZMpcY-00042-00019636-00020159": "This one is showing that there is 1 unread message - which just means that there has", "g3LxYBZMpcY-00043-00020159-00020673": "been a message posted to this forum since the last time you logged in to this course.", "g3LxYBZMpcY-00044-00020673-00021188": "These \"unread message\" indicators can really help you keep track of discussion forum conversations", "g3LxYBZMpcY-00045-00021188-00021461": "throughout the course.", "g3LxYBZMpcY-00046-00021461-00021982": "The Post Your Questions Here forum is a place for you to ask course-related question - anyone", "g3LxYBZMpcY-00047-00021982-00022507": "can post a message to this forum, and anyone can reply to a post in this forum, so try", "g3LxYBZMpcY-00048-00022507-00022754": "to help each other out.", "g3LxYBZMpcY-00049-00022754-00023254": "At the top-left of each week of content you'll see the Week number listed.", "g3LxYBZMpcY-00050-00023254-00023653": "Use this to help keep you oriented.", "g3LxYBZMpcY-00051-00023653-00024026": "The first item in each week is a Tasks list.", "g3LxYBZMpcY-00052-00024026-00024323": "This is where you'll find all your weekly assignments.", "g3LxYBZMpcY-00053-00024323-00024792": "To open it, just click the link and a new window will open displaying everything that", "g3LxYBZMpcY-00054-00024792-00025077": "is required for you to complete this week.", "g3LxYBZMpcY-00055-00025077-00025493": "You should print this page and use it as your \"checklist\" to make sure you complete all", "g3LxYBZMpcY-00056-00025493-00025750": "the required assignments for the week.", "g3LxYBZMpcY-00057-00025750-00026277": "And please make sure to read your syllabus completely for all the course information", "g3LxYBZMpcY-00058-00026277-00026957": "including course policies, assignments, grades, and schedule etc.", "g3LxYBZMpcY-00059-00026957-00027647": "In addition to any class textbooks, in your Insight online course you'll find online \"Books\".", "g3LxYBZMpcY-00060-00027647-00027938": "These books supplement the textbook.", "g3LxYBZMpcY-00061-00027938-00028411": "Click the link to open the book and notice how the page is laid out.", "g3LxYBZMpcY-00062-00028411-00028983": "You'll see the main content of the page in the middle -- this can be text, pictures,", "g3LxYBZMpcY-00063-00028983-00029511": "or links to articles to read, and even videos that you are to watch.", "g3LxYBZMpcY-00064-00029511-00029872": "Each book contains multiple \"pages\" of material.", "g3LxYBZMpcY-00065-00029872-00030331": "To progress through the content, you can use either the right and left arrow icons at the", "g3LxYBZMpcY-00066-00030331-00030997": "top and bottom right of the page, or use the clickable table of contents on the left side", "g3LxYBZMpcY-00067-00030997-00031253": "of the page.", "g3LxYBZMpcY-00068-00031253-00031894": "If you want, you can print out either a single page or the entire online book using the icons", "g3LxYBZMpcY-00069-00031894-00032168": "visible at the top of this page.", "g3LxYBZMpcY-00070-00032168-00032627": "Some students find this helpful, but just remember that you won't be able to watch any", "g3LxYBZMpcY-00071-00032627-00033106": "videos, or click any web page links, or submit any assignments from the printout.", "g3LxYBZMpcY-00072-00033106-00033538": "It can be useful if you wanted to read the text from paper, rather than on your computer", "g3LxYBZMpcY-00073-00033538-00033691": "screen.", "g3LxYBZMpcY-00074-00033691-00034187": "From any page in your online course, you'll see this breadcrumb trail, located in the", "g3LxYBZMpcY-00075-00034187-00034525": "grey bar in the upper-left of the page.", "g3LxYBZMpcY-00076-00034525-00034978": "You can use this to navigate back to different location in the course.", "g3LxYBZMpcY-00077-00034978-00035616": "The rightmost entry on the breadcrumb trail indicates where you are in the course currently.", "g3LxYBZMpcY-00078-00035616-00035981": "This is the online book we are currently looking at.", "g3LxYBZMpcY-00079-00035981-00036475": "The link just to the left indicates the next level up in the course.", "g3LxYBZMpcY-00080-00036475-00036950": "Clicking it would take you back up one level in the course, in this case, to all the other", "g3LxYBZMpcY-00081-00036950-00037168": "\"Books\" in this course.", "g3LxYBZMpcY-00082-00037168-00037765": "Continuing to the left, you see the link to the next level up in the course, for example", "g3LxYBZMpcY-00083-00037765-00038522": "to \"HLTH 97\" or what ever the course number, which is the homepage for the course.", "g3LxYBZMpcY-00084-00038522-00039030": "This is probably what you'll use most often to \"get back home\".", "g3LxYBZMpcY-00085-00039030-00039480": "The InsightHome link takes you back out too far -- to where you have to choose your course", "g3LxYBZMpcY-00086-00039480-00040053": "- so this course number will probably be the most useful.", "g3LxYBZMpcY-00087-00040053-00040759": "When you get to the last page of a book, clicking \"Next\" also returns you to the course homepage.", "g3LxYBZMpcY-00088-00040759-00041244": "In the right-side column you'll find some additional tools that can be quite helpful.", "g3LxYBZMpcY-00089-00041244-00041722": "The Sections Links area at the top of the column displays week numbers.", "g3LxYBZMpcY-00090-00041722-00042288": "So when we get to week 5 of this class, rather than scrolling way down the long course homepage", "g3LxYBZMpcY-00091-00042288-00042878": "-- you can simply click the 5 and jump right to Week 5 of course materials.", "g3LxYBZMpcY-00092-00042878-00043371": "Earlier I said that the forums are a public place were anyone can post, and you can reply", "g3LxYBZMpcY-00093-00043371-00043527": "to each others posts.", "g3LxYBZMpcY-00094-00043527-00044066": "If, however, you have a question of a personal nature, you can use the Walled Garden Mail", "g3LxYBZMpcY-00095-00044066-00044231": "system.", "g3LxYBZMpcY-00096-00044231-00044662": "You and your instructor both have a \"normal\" email address that you use.", "g3LxYBZMpcY-00097-00044662-00045259": "I'll call this your \"external email account\" and it might be your Yahoo, Google or other", "g3LxYBZMpcY-00098-00045259-00045378": "email account.", "g3LxYBZMpcY-00099-00045378-00046038": "In Insight, we have an \"internal email\" system that lets you send private messages to either", "g3LxYBZMpcY-00100-00046038-00046393": "another student in this class, or to your instructor.", "g3LxYBZMpcY-00101-00046393-00046852": "Please consider using this Walled Garden email when you have a question that is of a private", "g3LxYBZMpcY-00102-00046852-00047052": "or personal nature.", "g3LxYBZMpcY-00103-00047052-00047668": "Unlike messages posted in a Forum, only you (the sender) and the recipient will be able", "g3LxYBZMpcY-00104-00047668-00048183": "to read the message you send through the Walled Garden email system.", "g3LxYBZMpcY-00105-00048183-00048656": "The Participants link is there just so you can see all the students who are taking this", "g3LxYBZMpcY-00106-00048656-00048871": "class with you.", "g3LxYBZMpcY-00107-00048871-00049296": "And lastly -- when you're finished with your online session and are ready to leave the", "g3LxYBZMpcY-00108-00049296-00049690": "computer, please remember to log yourself out of the course.", "g3LxYBZMpcY-00109-00049690-00050215": "Just get back to the course homepage, scroll to the very top of the page, and then click", "g3LxYBZMpcY-00110-00050215-00050249": "Logout."}}, {"audio_id": "g3Sil5e_xrA", "text": {"g3Sil5e_xrA-00000-00000069-00000425": "OH Tanrım ooohh öhhhh", "g3Sil5e_xrA-00001-00000425-00000821": "çok güzel görünüyor", "g3Sil5e_xrA-00002-00000821-00001325": "hazır mısın ? Evet bu berbat bir şey", "g3Sil5e_xrA-00003-00001325-00001813": "ben hazırım ya sen . aynen bende hazırım", "g3Sil5e_xrA-00004-00001813-00002169": "kısaca : dikkatli ol si... he amk sus", "g3Sil5e_xrA-00005-00002169-00002573": "tamam , çekme yerini eline al", "g3Sil5e_xrA-00006-00002573-00002948": "yeah yes", "g3Sil5e_xrA-00007-00002948-00003357": "oldu gibi", "g3Sil5e_xrA-00008-00003357-00003730": "doğru kullanmıyoruz ama yinede korkmuyorum", "g3Sil5e_xrA-00009-00003730-00004079": "çekiyom . çek çek", "g3Sil5e_xrA-00010-00004079-00004434": "- hızlıca çekcem . Eminmisin  -evet", "g3Sil5e_xrA-00011-00004434-00004802": "sevdin mi bunu", "g3Sil5e_xrA-00012-00004802-00005146": "hazırsın", "g3Sil5e_xrA-00013-00005146-00005503": "bir kerede bitirecem", "g3Sil5e_xrA-00014-00005503-00005823": "içinden gecen : amk yavaş çek dedik sikik", "g3Sil5e_xrA-00015-00005823-00005848": "I"}}, {"audio_id": "g4gwEy0WV2I", "text": {"g4gwEy0WV2I-00000-00000063-00000949": "Allahumma salli wa sallim wa barik ala sayyidina muhammadin wa ala alihi adada inamillahi wa ifdali", "g4gwEy0WV2I-00001-00000978-00001173": "Audhu billahi min ash shaytanir rajim", "g4gwEy0WV2I-00002-00001173-00001339": "Bismillahir rahmanir Rahim", "g4gwEy0WV2I-00003-00001339-00002750": "Prophet Temail, the second son of the Prophet Hamail, took the duty of prophethood approximately two years after his brother's duty in this region.", "g4gwEy0WV2I-00004-00002750-00003346": "But the prophethood given to him was not for this region.", "g4gwEy0WV2I-00005-00003346-00004183": "It was taken on the task of breaking the effect of the Germanic influence in North Africa with the Tevhid Creed existing in this region,", "g4gwEy0WV2I-00006-00004183-00004602": "and to set a barrier to the western region of the Hejaz region.", "g4gwEy0WV2I-00007-00004602-00005335": "In other words, throughout history, we will be traveling to the east, west, north, and south of the Hejaz region,", "g4gwEy0WV2I-00008-00005335-00006539": "because Allah Dhul-Jalal always provided the protection of the truth and wisdom within the Kaaba and Medina by the hands of His Prophets.", "g4gwEy0WV2I-00009-00006539-00007650": "Throughout history, all Prophets have the duty of spreading the Tawhid Creed, as well as fulfilling their duties within", "g4gwEy0WV2I-00010-00007650-00009213": "their lifetime when their time comes about constituting evidence for the starting point of the Tawhid which is the Kaaba, and about the existence of the Prophet (Muhammad) Alaihissalatu Wassalam.", "g4gwEy0WV2I-00011-00009213-00010538": "And now we are going to the times when the first foundations of the Pharaoh family were laid especially after the Prophet Moses, which we read in the Qur’an.", "g4gwEy0WV2I-00012-00010538-00011169": "Pharaoh's family is actually of Germanic Arab origin, with a Syriac nature.", "g4gwEy0WV2I-00013-00011169-00012357": "Later on, we can say that a significant part of this family going backwards, they are brothers with the racial roots of today's England in the northern region of Europe.", "g4gwEy0WV2I-00014-00012357-00012759": "So they have a first cousin relationship between them, a great similarity.", "g4gwEy0WV2I-00015-00012759-00013449": "As Hazrat Temail is on his way to the region, he first stops by Jerusalem.", "g4gwEy0WV2I-00016-00013449-00014512": "In the inheritance he received from his brother, that is, within this truth he will carry out with him, the provisions of the same sharia, they will continue their lives with the provisions of the sharia left from Hazrat Hamail.", "g4gwEy0WV2I-00017-00014512-00015112": "There is not such a big change in the sharia yet, so to speak.", "g4gwEy0WV2I-00018-00015112-00015877": "We have been on the same sharia since Hazrat Noah Alaihissalam, and we are going back and forth between 9500 BCE and 9000 BCE.", "g4gwEy0WV2I-00019-00015877-00016961": "Hazrat Temail will go to the Jerusalem region with the doctors that were trained in Göbeklitepe, which he took with him with the advice of his brother,", "g4gwEy0WV2I-00020-00016961-00017788": "strengthening it with his own knowledge, he will establish a similar hospital in this region to break the Germanic influence in the region,", "g4gwEy0WV2I-00021-00017788-00018406": "and while treating the illnesses in this region, to settle the Tawhid Creed as his duty.", "g4gwEy0WV2I-00022-00018406-00019235": "At first, they prefer to go to the southern part of Egypt. So they will go to today's Somalia, Ethiopia region.", "g4gwEy0WV2I-00023-00019271-00019912": "However, in the summary of the essence of all the work to be carried out in the region of Somalia and Ethiopia,", "g4gwEy0WV2I-00024-00019912-00020786": "there was an important trade route extending from Egypt to Ethiopia through the trade routes of the people of that region due to the various movements from the north each time.", "g4gwEy0WV2I-00025-00020786-00021597": "Because we see trade routes in Africa with three or four main branches. From here we see that people constantly get affected and that they come out of the Tawhid Creed.", "g4gwEy0WV2I-00026-00021597-00022312": "Therefore, you will see that the first pyramid-like structures built are actually in the Sudan region today.", "g4gwEy0WV2I-00027-00022312-00022772": "We are talking about hundreds or even thousands of pyramids in this region, large and small.", "g4gwEy0WV2I-00028-00022772-00023184": "All of them are pyramid-like structures similar to Göbeklitepe.", "g4gwEy0WV2I-00029-00023184-00024004": "But they are built as small structures. However, it is understood that it is necessary to go north to break this Germanic influence gradually.", "g4gwEy0WV2I-00030-00024004-00024631": "However, due to the nature of the people of the region, they do not have warrior characteristics.", "g4gwEy0WV2I-00031-00024631-00025772": "So, in order to stay protected and to break the Germanic influence there politically, the arrival of a group of people from the Sons of Israel coming to the northern region has been realised by Hazrat Temail.", "g4gwEy0WV2I-00032-00025772-00026598": "So today, the fact that Prophet Moses Alaihissalam meets the Sons of Israel in Egypt is due to the main racial roots of the Sons of Israel,", "g4gwEy0WV2I-00033-00026598-00027633": "which was brought to Egypt during the time of Hazrat Temail in the years of 9000 BCE, around 9250 BCE – 9270 BCE.", "g4gwEy0WV2I-00034-00027633-00027977": "There is an important structure in this region.", "g4gwEy0WV2I-00035-00027977-00029049": "Some people from Germania who are in constant contact with the jinn and beings in the desert intend to establish an important structure in order to get help from different entities against the Tawhid Creed,", "g4gwEy0WV2I-00036-00029049-00030306": "against the people of Göbeklitepe, who have inescapable medical knowledge, and to announce this help to the world. Based on these intentions, we will be going to the basis of the first pyramid constructions.", "g4gwEy0WV2I-00037-00030306-00032040": "Of course, the Egyptian Civilisation and the construction of the pyramids is after this. But we will begin to see the structuring within this period as of this origin in history.", "g4gwEy0WV2I-00038-00032040-00033018": "In other words, there were pyramids already built before the present state of the pyramids today, which were built around 2500 BCE and said to have been built by Cheops.", "g4gwEy0WV2I-00039-00033018-00033575": "But these pyramids and those pyramids have been getting mixed up with each other throughout history.", "g4gwEy0WV2I-00040-00033575-00034498": "Especially those who demand help from the beings in space, as we have mentioned in previous civilisations,", "g4gwEy0WV2I-00041-00034498-00035369": "due to the various data found in this region, they enter a struggle to make a structure that will extinguish Göbeklitepe all over the world by getting help from aliens.", "g4gwEy0WV2I-00042-00035369-00036877": "And indeed, there was a big pyramid-like structure in the place of this great pyramid that you see now in this region in around 9000 BCE, though it was not as big as this one. But the base was a little more rounded, not that angular.", "g4gwEy0WV2I-00043-00036877-00037727": "Therefore, the pyramids we see today were built on the destroyed foundations of those first pyramids, just like Hagia Sophia.", "g4gwEy0WV2I-00044-00037727-00038220": "You can think of it like this, it got burned a few times, demolished, and then the latest version was rebuilt in its place.", "g4gwEy0WV2I-00045-00038220-00038748": "Help has been received from aliens, which is why this has been talked about to this day.", "g4gwEy0WV2I-00046-00038748-00039460": "But, as we can see with the hieroglyphs and the pictures that people work with, we see people do it too, which we need to combine now.", "g4gwEy0WV2I-00047-00039460-00040378": "Because against Hazrat Temail, against the Tawhid Creed he brought, a high place was to be built to be heard all over the world that will crush Göbeklitepe,", "g4gwEy0WV2I-00048-00040378-00041054": "Because against Hazrat Temail, against the Tawhid Creed he brought, a high place was to be built to be heard all over the world that will crush Göbeklitepe,", "g4gwEy0WV2I-00049-00041054-00041627": "started to do something in the circle of small possibilities that they partially received from the aliens.", "g4gwEy0WV2I-00050-00041627-00042933": "Hence, Hazrat Temail told them this; humans are superior to aliens and any other beings we see. It has more attributes. Because human is the most honourable creature.", "g4gwEy0WV2I-00051-00042933-00043952": "Therefore, the conflict between Prophet Moses and the magicians, which is clearly stated in the Qur'an, is actually not the first.", "g4gwEy0WV2I-00052-00043952-00044698": "It continues throughout history. So to speak, the most famous incident takes place when they meet Prophet Moses.", "g4gwEy0WV2I-00053-00044698-00045291": "Just like how the existence of Khidr Alaihissalam cannot be understood only with Prophet Moses.", "g4gwEy0WV2I-00054-00045291-00045826": "Hence, when we come to those chapters, inshaallah we will be expressing why he was told there.", "g4gwEy0WV2I-00055-00045826-00046977": "Hazrat Temail builds a great structure to show that this can be done by human hands and that it is possible without even using any Divine Miracle.", "g4gwEy0WV2I-00056-00046977-00047644": "It is such a large structure that it is about two, two and a half times higher than the other.", "g4gwEy0WV2I-00057-00047644-00049282": "However, the fact that this is in question in two different ilm (knowledge) centres requires Germania to create a different ground for the regional conflict. For this, they start working in the field of magic.", "g4gwEy0WV2I-00058-00049282-00050206": "In other words, you can think of that point where magic started in history as the stage of establishing the Masjid al-Dirar in Medina, so to speak.", "g4gwEy0WV2I-00059-00050206-00050975": "Therefore, Germania, which strives for the claim of the existence of a more advanced medical centre than Göbeklitepe,", "g4gwEy0WV2I-00060-00050975-00051622": "begins to get crushed in the face of the pyramids built by Hazrat Temail with humans.", "g4gwEy0WV2I-00061-00051622-00052552": "In the historical period, the other side begins to disappear. Therefore, Germania slowly begins to retreat towards the Strait of Gibraltar.", "g4gwEy0WV2I-00062-00052552-00053753": "However, the spread of this persistent understanding of Tawhid in Egypt and the development of the racial form in this region does not make Germania very", "g4gwEy0WV2I-00063-00053753-00054772": "peaceful that in the historical period they come back and destroy the pyramids, which have a more rounded structure in its foundation and is about a third the size of today's pyramids,", "g4gwEy0WV2I-00064-00054772-00055623": "and they will actually be doing various things with the hands of the Egyptian Pharaohs and under the influence of magic.", "g4gwEy0WV2I-00065-00055623-00057073": "The fact that they go forward in magic and the fact that the Prophets, who have the Faith of Tawhid, are declaring the truth with complete truthfulness causes the Tawhid to spread in this region.", "g4gwEy0WV2I-00066-00057073-00058048": "The influence of Germania breaks and this period of breaking up is quite effective until the coming of our Prophet Abraham before common era.", "g4gwEy0WV2I-00067-00058048-00059118": "Until about 500 to 780 years before the arrival of our Prophet Abraham, the effect of the Tawhid Creed spreads throughout Africa.", "g4gwEy0WV2I-00068-00059118-00059770": "Therefore, the starting point of the pyramids we are talking about today is again a conflict of Tawhid.", "g4gwEy0WV2I-00069-00059770-00060501": "The fight between the light and the darkness. But the victorious is always and certainly Allah Almighty.", "g4gwEy0WV2I-00070-00060501-00061733": "And there is no one who can extinguish His light. Each time Tawhid illuminates the world with this light. Let the opposite side try to do these with all their magic and power.", "g4gwEy0WV2I-00071-00061733-00062356": "Now we have gone to the west side of the world but what's going on in the east side?", "g4gwEy0WV2I-00072-00062356-00063222": "We will continue a little bit with that part and to our flow in history. See you tomorrow. May Allah protect you. Take care."}}, {"audio_id": "g4lTe7ikOLo", "text": {"g4lTe7ikOLo-00000-00000059-00000729": "You can easily move material from one course to another course. To do this, go", "g4lTe7ikOLo-00001-00000729-00001623": "into the course where you want the material. Go to settings, import course", "g4lTe7ikOLo-00002-00001623-00003225": "content. Select 'copy a canvas course'. Type in the name of your course, and then", "g4lTe7ikOLo-00003-00003225-00004007": "'select specific content'. If this content has dates, you can adjust those", "g4lTe7ikOLo-00004-00004007-00005046": "or remove them, and then hit import. It will come up with a select content", "g4lTe7ikOLo-00005-00005046-00005603": "button. Click on that and here you can choose what you want to put into this", "g4lTe7ikOLo-00006-00005603-00006150": "course. You can drill down on many of these. If you click on the arrow, it will", "g4lTe7ikOLo-00007-00006150-00006639": "give you the specific modules. If you have a quiz that you want to put in, you", "g4lTe7ikOLo-00008-00006639-00007445": "can drill down and find the specific quiz or you can select all. Sometimes", "g4lTe7ikOLo-00009-00007445-00008054": "other items will be associated with it, and they will come over at the same time.", "g4lTe7ikOLo-00010-00008054-00008804": "Once you've selected what you want to put in, click on 'select content'. It will run,", "g4lTe7ikOLo-00011-00008804-00009275": "and then it will say completed."}}, {"audio_id": "g4qEnDRSkG0", "text": {"g4qEnDRSkG0-00000-00000000-00000200": "Khủng long bạo chúa thời tiền sử"}}, {"audio_id": "g4r9FyXufAE", "text": {"g4r9FyXufAE-00000-00000000-00000050": "."}}, {"audio_id": "g4tjcX17EHY", "text": {"g4tjcX17EHY-00000-00000130-00000709": "I still see your shadows in my room Can't take back the love that I gave you", "g4tjcX17EHY-00001-00000709-00001035": "It's to the point where I love and I hate you", "g4tjcX17EHY-00002-00001035-00001459": "And I cannot change you so I must replace you (oh)", "g4tjcX17EHY-00003-00001459-00001823": "Easier said than done I thought you were the one", "g4tjcX17EHY-00004-00001823-00002256": "Listening to my heart instead of my head You found another one, but", "g4tjcX17EHY-00005-00002256-00002746": "I am the better one I won't let you forget me", "g4tjcX17EHY-00006-00002746-00003229": "You left me falling and landing inside my grave", "g4tjcX17EHY-00007-00003229-00004339": "I know that you want me dead I take prescriptions to make me feel A-Okay", "g4tjcX17EHY-00008-00004339-00004953": "I know it's all in my head...", "g4tjcX17EHY-00009-00004953-00005469": "I have these lucid dreams where I can't move a thing", "g4tjcX17EHY-00010-00005469-00005853": "Thinking of you in my bed...", "g4tjcX17EHY-00011-00005853-00006589": "You were my everything Thoughts of a wedding ring", "g4tjcX17EHY-00012-00006589-00006934": "Now I'm just better off dead...", "g4tjcX17EHY-00013-00006934-00007420": "I'll do it over again I didn't want it to end", "g4tjcX17EHY-00014-00007420-00007684": "I watched it blow in the wind I should've listened to my friends", "g4tjcX17EHY-00015-00007684-00007954": "Did this shit in the past But I want it to last", "g4tjcX17EHY-00016-00007954-00008286": "You were made outta plastic (fake!)", "g4tjcX17EHY-00017-00008286-00008675": "I was tangled up in your drastic ways Who knew evil girls have the prettiest face?", "g4tjcX17EHY-00018-00008675-00009260": "You gave me a heart that was full of mistakes I gave you my heart and you made heart break", "g4tjcX17EHY-00019-00009260-00009898": "You made my heart break You made my heart ache (I still see your shadows", "g4tjcX17EHY-00020-00009898-00010018": "in my room) You made my heart break", "g4tjcX17EHY-00021-00010018-00010472": "You made my heart ache (can't take back the love that I gave you)", "g4tjcX17EHY-00022-00010472-00010676": "You made my heart break (were made outta plastic, fake)", "g4tjcX17EHY-00023-00010676-00011017": "You made my heart ache (I still see your shadows in my room)", "g4tjcX17EHY-00024-00011017-00011301": "You made my heart break again (I was tangled up your drastic ways)", "g4tjcX17EHY-00025-00011301-00011470": "(Who knew evil girls have the prettiest face?)", "g4tjcX17EHY-00026-00011470-00011960": "I still see your shadows in my room Can't take back the love that I gave you", "g4tjcX17EHY-00027-00011960-00012236": "It's to the point where I love and I hate you", "g4tjcX17EHY-00028-00012236-00012535": "And I cannot change you so I must replace you (oh)", "g4tjcX17EHY-00029-00012535-00012872": "Easier said than done I thought you were the one", "g4tjcX17EHY-00030-00012872-00013291": "Listening to my heart instead of my head You found another one, but", "g4tjcX17EHY-00031-00013291-00013562": "I am the better one I won't let you forget me"}}, {"audio_id": "g4u8XCBHtqc", "text": {"g4u8XCBHtqc-00000-00000000-00132200": "Relaxing Music"}}, {"audio_id": "g4B9PebCm-Y", "text": {"g4B9PebCm-Y-00000-00008944-00009984": "do", "g4B9PebCm-Y-00001-00010536-00011384": "so", "g4B9PebCm-Y-00002-00020184-00021184": "so", "g4B9PebCm-Y-00003-00029624-00030983": "and weather", "g4B9PebCm-Y-00004-00032127-00032383": "things", "g4B9PebCm-Y-00005-00034328-00035184": "so"}}]