[{"audio_id": "izt-72nTIhc", "text": {"izt-72nTIhc-00000-00002500-00002794": "Hello, folks. It is a pleasure to be here again.", "izt-72nTIhc-00001-00002828-00003192": "Well, as we are already grounded in talking about the Men in the Middle-earth,", "izt-72nTIhc-00002-00003204-00003544": "The last Sunday video was about  the Men of Darkness,", "izt-72nTIhc-00003-00003568-00004134": "so, let us go to those favorites among many readers: the Riders of Rohan.", "izt-72nTIhc-00004-00004212-00004412": "Today’s video goes to ...", "izt-72nTIhc-00005-00005290-00005832": "Before anything, if you want to know about the noble race of horses, the Mearas,", "izt-72nTIhc-00006-00005832-00006108": "and also about Scadufax,  who was their leader,", "izt-72nTIhc-00007-00006114-00006688": "check out TTs #16 and #19,  which are specifics about these themes.", "izt-72nTIhc-00008-00006800-00007070": "The links are below the video description.", "izt-72nTIhc-00009-00007084-00007373": "So, we will not talk too much about horses,", "izt-72nTIhc-00010-00007406-00007752": "because Cesar already talked about them  in those indicated videos.", "izt-72nTIhc-00011-00007830-00008434": "As you know, the Rohirrim dwelt in Rohan, the neighboring land and allied of Gondor.", "izt-72nTIhc-00012-00008462-00008870": "This term “Rohirrim” was used more by  the other people,", "izt-72nTIhc-00013-00008890-00009516": "as they themselves used to use “Eorlingas”, in mention to King Eorl, the Young.", "izt-72nTIhc-00014-00009576-00009936": "“The Riders of Rohan” was the used term  to the soldiers,", "izt-72nTIhc-00015-00009952-00010238": "whose specialty was war on horseback.", "izt-72nTIhc-00016-00010280-00010758": "The King had a special detachment  called “King’s Riders”.", "izt-72nTIhc-00017-00010822-00011412": "The word “Rohirrim” is in Sindarin,  that means “the host of the Horse-lords”.", "izt-72nTIhc-00018-00011526-00011861": "The Rohirrim’s ancestors are the Northmen,", "izt-72nTIhc-00019-00011861-00012167": "in the First Age, those who not entered  in Beleriand,", "izt-72nTIhc-00020-00012178-00012466": "but also did not fall under the shadow  of the Dark Lord.", "izt-72nTIhc-00021-00012566-00012927": "From these ancestors, came the Éothéod,", "izt-72nTIhc-00022-00012927-00013253": "who dwelt in the Vales  of the Great River Anduin,", "izt-72nTIhc-00023-00013253-00013513": "between Carrock and Gladden Fields.", "izt-72nTIhc-00024-00013538-00013856": "According to the Dúnedain tradition classification,", "izt-72nTIhc-00025-00013856-00014176": "the Rohirrim are included into  the Middle Men.", "izt-72nTIhc-00026-00014204-00014841": "I showed this classification on the TT #82. Check the link below the video description.", "izt-72nTIhc-00027-00015034-00015654": "Well, the Éothéod left the north of the Mirkwood after the Battle of the Plains,", "izt-72nTIhc-00028-00015672-00015954": "when the region was dominated  by the Wainriders.", "izt-72nTIhc-00029-00015963-00016471": "Therefrom, the Éothéod went to west Rhovanion and lived in the north", "izt-72nTIhc-00030-00016471-00016938": "between 1856 and 2510 of the First Age.", "izt-72nTIhc-00031-00016976-00017460": "They settled between west bank of  the River Anduin and the Mirkwood.", "izt-72nTIhc-00033-00018342-00018917": "Around the year 1899 of the Third Age,  there was a joining of forces between", "izt-72nTIhc-00034-00018917-00019129": "the Éothéod and the Gondorians,", "izt-72nTIhc-00035-00019144-00019642": "because the Lord of the Éothéod, Marhwini, warned the King Calimentar, of Gondor,", "izt-72nTIhc-00036-00019646-00019962": "that the Wainriders intended to attack Calenardhon.", "izt-72nTIhc-00037-00019988-00020310": "Together, they managed to fend off  the Wainriders.", "izt-72nTIhc-00038-00020366-00020966": "In the time of Forthwini, Marhwini’s son, the Wainriders returned to disturb the Éothéod", "izt-72nTIhc-00039-00020970-00021268": "and, so, the King Ondoher, of Gondor,  was warned.", "izt-72nTIhc-00040-00021316-00021756": "Once again, the alliance between the two peoples fought against the Wainriders.", "izt-72nTIhc-00041-00022090-00022844": "After the fall of the Kingdom of Angmar,  in T. A., 1975, the Lord Frumgar led", "izt-72nTIhc-00042-00022844-00023044": "the Éotheód farther north,", "izt-72nTIhc-00043-00023050-00023516": "next the place where the Misty Mountains met with the Grey Mountains", "izt-72nTIhc-00045-00024488-00025044": "It was there that the King Fram, Frumgar’s son slew the dragon Scatha, the Worm,", "izt-72nTIhc-00046-00025044-00025229": "which come from the Mountains.", "izt-72nTIhc-00047-00025262-00025786": "Fram got Scatha’s treasure, but this resulted in a misunderstanding with the Dwarves.", "izt-72nTIhc-00048-00025822-00026285": "[ The Lord of the Rings – Appendix –  The House of Eorl ]", "izt-72nTIhc-00049-00026354-00026822": "“Frumgar, they say, was the name of the chieftain who led his people to Éothéod.", "izt-72nTIhc-00050-00026839-00027380": "Of his son, Fram, they tell that he slew Scatha, the great dragon of Ered Mithrin,", "izt-72nTIhc-00051-00027394-00027668": "and the land had peace from  the long-worms afterwards.", "izt-72nTIhc-00052-00027670-00028164": "Thus Fram won great wealth,  but was at feud with the Dwarves,", "izt-72nTIhc-00053-00028177-00028420": "who claimed the hoard of Scatha.", "izt-72nTIhc-00054-00028439-00028864": "Fram would not yield them a penny,", "izt-72nTIhc-00055-00028876-00029414": "and sent to them instead the teeth of Scatha made into a necklace, saying:", "izt-72nTIhc-00056-00029420-00029734": "\"Jewels such as these you will not match  in your treasuries....", "izt-72nTIhc-00057-00029734-00029933": "....for they are hard to come by.\"", "izt-72nTIhc-00058-00029948-00030277": "Some say that the Dwarves slew Fram  for this insult.", "izt-72nTIhc-00059-00030288-00030592": "There was no great love between Éothéod and the Dwarves.”", "izt-72nTIhc-00060-00030633-00031164": "After that, almost nothing was registered  in the history, until a posterior king, Léod,", "izt-72nTIhc-00061-00031180-00031606": "trying to tame the horse Felaróf,  the first of Rohan’s Mearas,", "izt-72nTIhc-00062-00031620-00032212": "died after to fall down and hit the head  on the rock. He was 42 years old.", "izt-72nTIhc-00063-00032232-00032830": "Who got to tame the beast was his son Eorl, the Young, with only 16 years old,", "izt-72nTIhc-00064-00032844-00033170": "who has since gone to ride Felaróf.", "izt-72nTIhc-00065-00033194-00033686": "[ The Lord of the Rings – Appendix  The House of Eorl ]", "izt-72nTIhc-00066-00033754-00033978": "“Eorl vowed that he would avenge his father.", "izt-72nTIhc-00067-00033978-00034302": "He hunted long for the horse,  and at last he caught sight of him;", "izt-72nTIhc-00068-00034324-00034778": "and his companions expected that he would try to come within bowshot and kill him.", "izt-72nTIhc-00069-00034796-00035260": "But when they drew near, Eorl stood up  and called in a loud voice:", "izt-72nTIhc-00070-00035278-00035616": "\"Come hither, Mansbane,  and get a new name!\"", "izt-72nTIhc-00071-00035632-00036172": "To their wonder the horse looked towards Eorl, and came and stood before him,", "izt-72nTIhc-00072-00036172-00036314": "and Eorl said:", "izt-72nTIhc-00073-00036314-00036797": "\"Felaróf I name you. You loved your freedom, and I do not blame you for that.", "izt-72nTIhc-00074-00036817-00037348": "But now you owe me a great weregild, and you shall surrender your freedom to me", "izt-72nTIhc-00075-00037348-00037510": "until your life's end.\"", "izt-72nTIhc-00076-00037510-00038028": "Then Eorl mounted him, and Felaróf submitted; and Eorl rode him home", "izt-72nTIhc-00077-00038028-00038420": "without bit or bridle; and he rode him in  like fashion ever after.”", "izt-72nTIhc-00078-00038468-00038855": "It was the epoch of Gondor’s Steward, Cirion, who was very afraid", "izt-72nTIhc-00079-00038855-00039050": "of attacks coming from the north", "izt-72nTIhc-00080-00039050-00039491": "when at last, both the Balchoth and orcs attacked Gondor,", "izt-72nTIhc-00081-00039491-00039691": "and Cirion sent messengers to Eorl.", "izt-72nTIhc-00082-00039744-00040114": "About the Balchoth, they are those  of the Men of Darkness", "izt-72nTIhc-00083-00040114-00040331": "who we talked about in the TT #82.", "izt-72nTIhc-00084-00040362-00040596": "Check the link in the video description.", "izt-72nTIhc-00085-00040634-00040948": "Eorl answered the calling and rode  to the south", "izt-72nTIhc-00086-00040956-00041336": "with most of the Éothéod,  about 7 thousand men,", "izt-72nTIhc-00087-00041338-00041704": "leaving some hundreds of warriors  to protect his kingdom.", "izt-72nTIhc-00088-00041748-00042198": "An interesting thing that happened here  is that, apparently, they were helped", "izt-72nTIhc-00089-00042204-00042514": "by the power of Galadriel  while they passed through Dol Guldur,", "izt-72nTIhc-00090-00042528-00042788": "because there was a kind of mist  where they entered", "izt-72nTIhc-00091-00042798-00043152": "and that chased away the darkness which came out of Necromancer’s Lair.", "izt-72nTIhc-00092-00043170-00043547": "[Unfinished Tales – Cirion and Eorl and the friendship of Gondor and Rohan", "izt-72nTIhc-00093-00043547-00043693": "– The Ride of Eorl]", "izt-72nTIhc-00094-00043722-00044042": "“For when at last the host drew near  to Dol Guldur,", "izt-72nTIhc-00095-00044054-00044342": "Eorl turned away westward for fear  of the dark shadow", "izt-72nTIhc-00096-00044342-00044494": "and cloud that flowed out from it,", "izt-72nTIhc-00097-00044494-00044748": "and then he rode on within sight of Anduin.", "izt-72nTIhc-00098-00044760-00045034": "Many of the riders turned their eyes thither,", "izt-72nTIhc-00099-00045038-00045524": "half in fear and half in hope to glimpse from afar the shimmer of the Dwimordene,", "izt-72nTIhc-00100-00045546-00045890": "the perilous land that in legends of their people was said to shine", "izt-72nTIhc-00101-00045890-00046046": "like gold in the springtime.", "izt-72nTIhc-00102-00046046-00046346": "But now it seemed shrouded  in a gleaming mist", "izt-72nTIhc-00103-00046362-00046800": "and to their dismay the mist passed over the river and flowed over the land", "izt-72nTIhc-00104-00046800-00046984": "before them. Eorl did not halt.", "izt-72nTIhc-00105-00047016-00047576": "\"Ride on!\" he commanded. \"There is no other way to take. After so long a road", "izt-72nTIhc-00106-00047578-00047890": "shall we be held back from battle  by a river-mist?\"", "izt-72nTIhc-00107-00047930-00048311": "As they drew nearer they saw that the white mist was driving back the glooms", "izt-72nTIhc-00108-00048311-00048540": "of Dol Guldur, and soon they passed into it,", "izt-72nTIhc-00109-00048540-00048824": "riding slowly at first and warily;", "izt-72nTIhc-00110-00048840-00049250": "but under its canopy all things were lit with a clear and shadowless light,", "izt-72nTIhc-00111-00049266-00049844": "while to left and right they were guarded  as it were by white walls of secrecy.", "izt-72nTIhc-00112-00049868-00050310": "\"The Lady of the Golden Wood is on  our side, it seems,\" said Borondir.", "izt-72nTIhc-00113-00050324-00050966": "\"Maybe,\" said Eorl. \"But at least I will trust the wisdom of Felaróf. He scents no evil.", "izt-72nTIhc-00114-00050970-00051354": "His heart is high, and his weariness  is healed:", "izt-72nTIhc-00115-00051354-00051725": "he strains to be given his head. So be it!", "izt-72nTIhc-00116-00051741-00052024": "For never have I had more need of secrecy and speed.\"”", "izt-72nTIhc-00117-00052224-00052668": "They had come to the Field of Celebrant  in time to assist Gondor’s army", "izt-72nTIhc-00118-00052668-00052848": "and defeat the enemies.", "izt-72nTIhc-00119-00053117-00053584": "After that, Gondor’s Steward called Eorl  to a place named Mering Stream,", "izt-72nTIhc-00120-00053612-00053960": "and there he passed Calenardhon  in the care of Rohirrim", "izt-72nTIhc-00121-00053970-00054414": "and arranged to meet Eorl again there  after three months.", "izt-72nTIhc-00122-00054452-00054733": "No one understanded anything because everybody thought he was going to reward", "izt-72nTIhc-00123-00054733-00054953": "the Riders in some way.", "izt-72nTIhc-00124-00055032-00055704": "In fact, Cirion took this time to order some men clean a path in the Whispering Wood.", "izt-72nTIhc-00125-00055717-00056000": "It was in the region of the Ered Nimrais.", "izt-72nTIhc-00126-00056024-00056588": "In this path, they would come to the Hill of Awe and the meet with Eorl would be there.", "izt-72nTIhc-00127-00056610-00056914": "That was when Cirion declared  his true intention.", "izt-72nTIhc-00128-00056944-00057313": "[ Unfinished Tales – Cirion and Eorl and the friendship of Gondor and Rohan", "izt-72nTIhc-00129-00057313-00057452": "– Cirion and Eorl]", "izt-72nTIhc-00130-00057479-00057908": "\"I will now declare what I have resolved, with the authority of the Stewards of the Kings,", "izt-72nTIhc-00131-00057929-00058279": "to offer to Eorl son of Léod,  Lord of the Éothéod,", "izt-72nTIhc-00132-00058279-00058524": "in recognition of the valour of his people", "izt-72nTIhc-00133-00058524-00059074": "and of the help beyond hope that he brought to Gondor in time of dire need.", "izt-72nTIhc-00134-00059094-00059746": "To Eorl I will give in free gift all the great land of Calenardhon from Anduin to Isen.", "izt-72nTIhc-00135-00059766-00060129": "There, if he will, he shall be kind,  and his heirs after him,", "izt-72nTIhc-00136-00060138-00060554": "and his people shall dwell in freedom while the authority of the Stewards endures,", "izt-72nTIhc-00137-00060554-00060754": "until the Great King returns.", "izt-72nTIhc-00138-00060774-00061264": "No bond shall be laid upon them other than their own laws and will,", "izt-72nTIhc-00139-00061264-00061455": "save in this only:", "izt-72nTIhc-00140-00061466-00061750": "they shall live in perpetual friendship  with Gondor", "izt-72nTIhc-00141-00061762-00062216": "and its enemies shall be their enemies while both realms endure.", "izt-72nTIhc-00142-00062224-00062602": "But the same bond shall be laid also  on the people of Gondor.\"", "izt-72nTIhc-00143-00062626-00063044": "Cirion had for Eorl, a fatherly love for  a strong son full of hope,", "izt-72nTIhc-00144-00063044-00063491": "when Eorl saw in Cirion the greatest nobleman and wisest he knew.", "izt-72nTIhc-00145-00063519-00063878": "[ Unfinished Tales – Cirion and Eorl and the friendship of Gondor and Rohan", "izt-72nTIhc-00146-00063878-00064036": "Cirion and Eorl]", "izt-72nTIhc-00147-00064052-00064412": "\"Lord Steward of the Great King, the gift that yon offer I accept", "izt-72nTIhc-00148-00064412-00064555": "for myself and for my people.", "izt-72nTIhc-00149-00064555-00064970": "It far exceeds any reward that our deeds could have earned,", "izt-72nTIhc-00150-00064974-00065328": "if they had not themselves been a free gift of friendship.", "izt-72nTIhc-00151-00065348-00065768": "But now I will seal that friendship with  an oath that shall not be forgotten.\"", "izt-72nTIhc-00152-00065776-00066239": "So, they went to the top of the hill and there, they found a place that was only known", "izt-72nTIhc-00153-00066239-00066594": "by the Kings and Stewards:  Elendil’s own tomb,", "izt-72nTIhc-00154-00066594-00066962": "which had been placed there by Isildur as  a symbol of the central point", "izt-72nTIhc-00155-00066962-00067105": "of the Southern Kingdom.", "izt-72nTIhc-00156-00067146-00067606": "It was a sacred place and was used  to oaths of the deepest solemnity.", "izt-72nTIhc-00157-00067649-00068167": "[ Unfinished Tales – Cirion and Eorl and  the friendship of Gondor and Rohan ]", "izt-72nTIhc-00158-00068274-00068720": "“Hear now all peoples who bow not  to the Shadow in the East,", "izt-72nTIhc-00159-00068738-00069117": "by the gift of the Lord of the Mundburg  we will come to dwell in the land", "izt-72nTIhc-00160-00069117-00069282": "that he names Calenardhon,", "izt-72nTIhc-00161-00069282-00069712": "and therefore I vow in my own name and  on behalf of the Éothéod of the North", "izt-72nTIhc-00162-00069730-00070178": "that between us and the Great People of the West there shall be friendship for ever:", "izt-72nTIhc-00163-00070204-00070736": "their enemies shall be our enemies,  their need shall be our need,", "izt-72nTIhc-00164-00070754-00071166": "and whatsoever evil, or threat,  or assault may come upon them", "izt-72nTIhc-00165-00071170-00071546": "we will aid them to the utmost end  of our strength.", "izt-72nTIhc-00166-00071612-00072200": "This vow shall descend to my heirs, all such as may come after me in our new land,", "izt-72nTIhc-00167-00072204-00072678": "and let them keep it in faith unbroken,  lest the Shadow fall upon them", "izt-72nTIhc-00168-00072678-00072852": "and they become accursed.", "izt-72nTIhc-00169-00072942-00073434": "Then Eorl sheathed his sword and bowed and went back to his captains.", "izt-72nTIhc-00170-00073502-00073662": "Cirion then made answer.", "izt-72nTIhc-00171-00073684-00074022": "Standing to his full height he laid  his hand upon the tomb", "izt-72nTIhc-00172-00074036-00074322": "and in his right hand held up the white wand of the Stewards,", "izt-72nTIhc-00173-00074328-00074714": "and spoke words that filled those who heard them with awe.", "izt-72nTIhc-00174-00074736-00075118": "For as he stood up the sun went down  in flame in the West", "izt-72nTIhc-00175-00075118-00075362": "and his white robe seemed to be on fire;", "izt-72nTIhc-00176-00075364-00075736": "and after he had vowed that Gondor should be bound by a like bond", "izt-72nTIhc-00177-00075744-00076270": "of friendship and aid in all need, he lifted up his voice and said in Quenya:", "izt-72nTIhc-00178-00076356-00076992": "Vanda sina termaruva Elenna-nóreo alcar enyalien ar Elendil Vorondo voronwë.", "izt-72nTIhc-00179-00077026-00077537": "Nai tiruvantes i hárar mahalmassen mi Númen ar i Eru", "izt-72nTIhc-00180-00077537-00077913": "i or ilyë mahalmar eä tennoio.", "izt-72nTIhc-00181-00077972-00078202": "And again he said the Common Speech:", "izt-72nTIhc-00182-00078206-00078604": "This oath shall stand in memory of the glory of the Land of the Star,", "izt-72nTIhc-00183-00078616-00078852": "and of the faith of Elendil the Faithful,", "izt-72nTIhc-00184-00078854-00079194": "in the keeping of those who sit upon  the thrones of the West", "izt-72nTIhc-00185-00079194-00079576": "and of the One who is above all thrones  for ever.”", "izt-72nTIhc-00186-00079654-00079957": "And that’s how, as a reward and thanks  for the help,", "izt-72nTIhc-00187-00079957-00080221": "Cirion gave Eorl the land of Calenardhon.", "izt-72nTIhc-00188-00080254-00080464": "After the oath of eternal friendship,", "izt-72nTIhc-00189-00080476-00080934": "the rest of the Éotheód came from north  to the plains of Calenardhon.", "izt-72nTIhc-00190-00080968-00081510": "From then on, they began to be called “Eorlingas”, which means “son of Eorl”.", "izt-72nTIhc-00191-00081522-00081800": "Their land they called “Mark”.", "izt-72nTIhc-00192-00081994-00082214": "Rohan you know where it is laid.", "izt-72nTIhc-00193-00082224-00082866": "North of Gondor, next the Misty Mountains, of Isengard and Fangorn Forest.", "izt-72nTIhc-00195-00083848-00084154": "The Ered Nimrais, the White Mountains.", "izt-72nTIhc-00196-00084450-00084872": "Edoras’ capital. The Helm’s Deep.", "izt-72nTIhc-00197-00085218-00085418": "Isengard.", "izt-72nTIhc-00198-00085644-00085910": "Fangorn Forest.", "izt-72nTIhc-00199-00086270-00086506": "The River Anduin.", "izt-72nTIhc-00200-00086906-00087172": "The old land of Calenardhon.", "izt-72nTIhc-00201-00087706-00088096": "As they were called Rohirrim  by the people of Gondor,", "izt-72nTIhc-00202-00088096-00088368": "their land became to be called Rohan.", "izt-72nTIhc-00203-00088402-00088736": "As I said, the Rohirrim were considered  the Middle Men,", "izt-72nTIhc-00204-00088746-00089188": "in other words, they were below the Dúnedain, who were the High Men.", "izt-72nTIhc-00205-00089224-00089429": "Thought, they were distantly relatives,", "izt-72nTIhc-00206-00089429-00089703": "because both were descended from  Men of the First Age,", "izt-72nTIhc-00207-00089712-00090062": "but Dúnedain’s ancestors went to Númenor,", "izt-72nTIhc-00208-00090078-00090410": "while Rohirrim’s ancestors remained  in the Middle-earth.", "izt-72nTIhc-00209-00090440-00090986": "The Gondorians claimed to be related  to Rohirrim because they did not want to feel", "izt-72nTIhc-00210-00090986-00091406": "diminished when Gondor gave Calenardhon to the Horsemen.", "izt-72nTIhc-00211-00091450-00091920": "As they lost part of their territory,  it was as if they were saying", "izt-72nTIhc-00212-00091922-00092208": "that only gave the land because  it went to their relatives.", "izt-72nTIhc-00213-00092270-00092786": "Aragorn who confirms that the Rohirrim really are from the Northmen of Rhovanion.", "izt-72nTIhc-00214-00092835-00093303": "[The Two Towers – The Riders of Rohan]", "izt-72nTIhc-00215-00093364-00093718": "“ 'What do you know of these horsemen, Aragorn?' he said.", "izt-72nTIhc-00216-00093780-00094058": "‘Do we sit here waiting for sudden death?'", "izt-72nTIhc-00217-00094082-00094496": "'I have been among them', answered Aragorn. 'They are proud and wilful,", "izt-72nTIhc-00218-00094496-00095154": "but they are true-hearted, generous in thought and deed; bold but not cruel;", "izt-72nTIhc-00219-00095168-00095634": "wise but unlearned, writing no books  but singing many songs,", "izt-72nTIhc-00220-00095636-00095972": "after the manner of the children of  Men before the Dark Years.", "izt-72nTIhc-00221-00096016-00096254": "But I do not know what has happened  here of late,", "izt-72nTIhc-00222-00096264-00096670": "nor in what mind the Rohirrim may now  be between the traitor Saruman", "izt-72nTIhc-00223-00096670-00096850": "and the threat of Sauron.", "izt-72nTIhc-00224-00096850-00097098": "They have long been the friends of the people of Gondor,", "izt-72nTIhc-00225-00097098-00097293": "though they are not akin to them.", "izt-72nTIhc-00226-00097330-00097772": "It was in forgotten years long ago that Eorl the Young brought them out of the North,", "izt-72nTIhc-00227-00097786-00098282": "and their kinship is rather with the Bardings of Dale, and with the Beornings of the Wood,", "izt-72nTIhc-00228-00098292-00098818": "among whom may still be seen many men tall and fair, as are the Riders of Rohan.", "izt-72nTIhc-00229-00098822-00099180": "At least they will not love the Orcs.”", "izt-72nTIhc-00230-00099206-00099642": "Apparently, Aragorn’s speech contradicts that the Rohirrim are distant relatives", "izt-72nTIhc-00231-00099642-00099692": "of Gondorians,", "izt-72nTIhc-00232-00099764-00100190": "but the truth is that Aragorn spoke that because there was that great division that,", "izt-72nTIhc-00233-00100204-00100638": "practically, the men who went to Númenor got completely disconnected", "izt-72nTIhc-00234-00100638-00100926": "from those of their kinship who had remained in the Middle-earth.", "izt-72nTIhc-00235-00100960-00101379": "Therefore, as Aragorn speaks, the closest kinship of the Horseman", "izt-72nTIhc-00236-00101379-00101516": "was to the Men of the Dale,", "izt-72nTIhc-00237-00101516-00101790": "because these also, were descended from the Northmen,", "izt-72nTIhc-00238-00101796-00102126": "those who remained in the Middle-earth, without going to Númenor", "izt-72nTIhc-00239-00102126-00102326": "or serving the Dark Lord.", "izt-72nTIhc-00240-00102350-00102685": "[ Unfinished Tales – Cirion and Eorl and the friendship of Gondor and Rohan –", "izt-72nTIhc-00241-00102685-00102885": "The Northmen and the Wainriders ]", "izt-72nTIhc-00242-00102900-00103239": "“These Northmen were descendants  of the same race of Men", "izt-72nTIhc-00243-00103239-00103394": "as those who in the First Age", "izt-72nTIhc-00244-00103394-00103784": "passed into the West of Middle-earth and became the allies of the Eldar", "izt-72nTIhc-00245-00103784-00104041": "in their wars with Morgoth.", "izt-72nTIhc-00246-00104056-00104470": "They were therefore from afar off kinsmen of the Dúnedain or Númenóreans,", "izt-72nTIhc-00247-00104474-00104776": "and there was great friendship between them and the people of Gondor.", "izt-72nTIhc-00248-00104788-00105324": "They were in fact a bulwark of Gondor, keeping its northern and eastern frontiers", "izt-72nTIhc-00249-00105332-00105678": "from invasion; though that was not fully realized by the Kings", "izt-72nTIhc-00250-00105690-00106056": "until the bulwark was weakened  and at last destroyed.”", "izt-72nTIhc-00251-00106090-00106480": "Rohan has a history marked by wars against the Men of Darkness,", "izt-72nTIhc-00252-00106500-00106980": "specially the Dunlendings,  but also the Balchoth and the Easterings,", "izt-72nTIhc-00253-00106980-00107180": "who were the ones who killed Eorl.", "izt-72nTIhc-00254-00107214-00107742": "The first royal lineage lasted 249 years,  until the king Helm Hammerhand.", "izt-72nTIhc-00255-00107780-00108002": "Many battles and wars continued,", "izt-72nTIhc-00256-00108002-00108440": "even against the Orcs, who wanted to claim a place to live in the White Mountains.", "izt-72nTIhc-00257-00108472-00108903": "When Saruman, the White, goes to live in Isengard, a friendship is born between", "izt-72nTIhc-00258-00108903-00109055": "him and the Rohirrim.", "izt-72nTIhc-00259-00109082-00109330": "There were three lineages in Rohan.", "izt-72nTIhc-00260-00109330-00109750": "The first from Eorl to Helm,  whose sons also died.", "izt-72nTIhc-00261-00109750-00110194": "Thus, Fréaláf, son of Helm’s sister,  was crowned.", "izt-72nTIhc-00262-00110216-00110708": "The second lineage lasted until Théoden, who fell in the Battle of the Pelennor Fields.", "izt-72nTIhc-00263-00110716-00111324": "After Théoden, his nephew, Éomer, took the throne, starting the third royal lineage.", "izt-72nTIhc-00264-00111338-00111632": "During Thengel’s reign, Théoden’s father,", "izt-72nTIhc-00265-00111633-00112098": "a certain foreigner from the north appears and provide service on the side of the king.", "izt-72nTIhc-00266-00112109-00112309": "He was a valorous warrior.", "izt-72nTIhc-00267-00112311-00112828": "The name he introduced himself with was 'Thorongil', which means “Eagle of the Star”.", "izt-72nTIhc-00268-00112870-00113192": "I think you should know who  I am talking about,", "izt-72nTIhc-00269-00113194-00113435": "but I won’t say today, because I want  to leave a suspense in the air", "izt-72nTIhc-00270-00113435-00113614": "for those who do not know…", "izt-72nTIhc-00271-00113614-00114000": "But do not worry, because soon Thorongil will appear here in the TT.", "izt-72nTIhc-00272-00114000-00114200": "We will talk about him.", "izt-72nTIhc-00273-00114200-00114678": "The capital of Rohan was Edoras, where was the golden palace of Meduseld.", "izt-72nTIhc-00274-00114770-00115074": "Edoras was founded by Brego, Eorl’s son.", "izt-72nTIhc-00275-00115133-00115548": "It was the second capital of the reign,  the first one was Aldburg.", "izt-72nTIhc-00276-00115588-00116035": "Besides westron, the Common Speech,  the Rohirrim spoke a language derived", "izt-72nTIhc-00277-00116038-00116309": "from the old language  of the Northmen of Rhovanion.", "izt-72nTIhc-00278-00116361-00116702": "An interesting thing is that many words from the language of the hobbits", "izt-72nTIhc-00279-00116702-00116985": "were the same words from the language  of the Rohirrim.", "izt-72nTIhc-00280-00117052-00117504": "This means that the two people have met when still there was the Éothéod,", "izt-72nTIhc-00281-00117516-00117978": "as they both lived there in the Vales of Anduin River, east of Misty Mountains.", "izt-72nTIhc-00282-00118109-00118648": "Physically, they were tall and slender,  blond hair as straw with long braids,", "izt-72nTIhc-00283-00118666-00118898": "austere and sharp faces.", "izt-72nTIhc-00284-00118898-00119130": "They used to carry long ash spears,", "izt-72nTIhc-00285-00119148-00119674": "painted shields in their back, longswords  in the girdle and metallic meshes.", "izt-72nTIhc-00286-00119744-00120212": "[ Unfinished Tales –  Númenórean Linear Measures ]", "izt-72nTIhc-00287-00120294-00120608": "“The Rohirrim were generally shorter,", "izt-72nTIhc-00288-00120609-00121041": "for in their far-off ancestry they had been mingled with men of broader...", "izt-72nTIhc-00289-00121041-00121091": "...and heavier build.", "izt-72nTIhc-00290-00121168-00121520": "Éomer was said to have been tall,  of like height with Aragorn;", "izt-72nTIhc-00291-00121528-00121948": "but he with other descendants of King Thengel were taller than the norm of Rohan,", "izt-72nTIhc-00292-00121964-00122444": "deriving this characteristic (together in some cases with darker hair) from Morwen,", "izt-72nTIhc-00293-00122458-00122911": "Thengel's wife, a lady of Gondor of high Númenórean descent.”", "izt-72nTIhc-00294-00122944-00123366": "The military organization of the Rohirrim was commanded by the Marshals.", "izt-72nTIhc-00295-00123418-00123856": "There was, for example, one Marshal in Edoras and another in Helm’s Deep.", "izt-72nTIhc-00296-00123932-00124266": "Éored was the given name to each  military unit,", "izt-72nTIhc-00297-00124266-00124505": "which usually was compound  by 120 Horsemen.", "izt-72nTIhc-00298-00124574-00124946": "The great enemies of the Horsemen were the Dunlendings, as has been said,", "izt-72nTIhc-00299-00124956-00125360": "and there was even a period when the Dunlending Wulf usurped the throne", "izt-72nTIhc-00300-00125360-00125926": "of Rohan, during the Long Winter. We will talk about it in future videos.", "izt-72nTIhc-00301-00126020-00126354": "During the War of the Ring,  Théoden’s reign withered", "izt-72nTIhc-00302-00126354-00126847": "due Gríma Wormtongue’s tricks, who  was an undercover agent of Saruman.", "izt-72nTIhc-00303-00126882-00127232": "Only with the arriving of Gandalf, the White, to Meduseld,", "izt-72nTIhc-00304-00127232-00127765": "it was discovered the cheat game and the king was released from the evil influence.", "izt-72nTIhc-00305-00128174-00128688": "In the ride of the Rohirrim to aid Gondor, they were helped by the Drúedain,", "izt-72nTIhc-00306-00128688-00129064": "the wild men that hated the orcs  and the Dark Lord.", "izt-72nTIhc-00307-00129104-00129420": "We will talk about them soon here in the TT.", "izt-72nTIhc-00308-00129490-00130030": "[ The Return of the King –  The Ride of the Rihirrim]", "izt-72nTIhc-00309-00130050-00130382": "“ Let Ghân-buri-Ghân finish!'  said the Wild Man.", "izt-72nTIhc-00310-00130418-00130809": "More than one road he knows.  He will lead you by road", "izt-72nTIhc-00311-00130811-00131192": "where no pits are, no gorgûn walk,  only Wild Men and beasts.", "izt-72nTIhc-00312-00131196-00131612": "Many paths were made when  Stonehouse-folk were stronger.", "izt-72nTIhc-00313-00131624-00131954": "They carved hills as hunters carve  beast-flesh.", "izt-72nTIhc-00314-00131954-00132282": "Wild Men think they ate stone for food.", "izt-72nTIhc-00315-00132282-00132710": "They went through Drúadan to Rimmon  with great wains.", "izt-72nTIhc-00316-00132732-00133286": "They go no longer. Road is forgotten,  but not by Wild Men.", "izt-72nTIhc-00317-00133326-00133770": "Over hill and behind hill it lies still  under grass and tree,", "izt-72nTIhc-00318-00133770-00134274": "there behind Rimmon and down to Dîn, and back at the end to Horse-men's road.", "izt-72nTIhc-00319-00134302-00134588": "Wild Men will show you that road.", "izt-72nTIhc-00320-00134590-00135052": "Then you will kill gorgûn and drive away bad dark with bright iron,", "izt-72nTIhc-00321-00135060-00135464": "and Wild Men can go back to sleep  in the wild woods.'", "izt-72nTIhc-00322-00135748-00136019": "Éomer and the king spoke together  in their own tongue.", "izt-72nTIhc-00323-00136019-00136332": "At length Théoden turned to the Wild Man.", "izt-72nTIhc-00324-00136332-00136552": "‘We will receive your offer’ he said.", "izt-72nTIhc-00325-00136564-00137030": "‘For though we leave a host of foes behind, what matter?", "izt-72nTIhc-00326-00137030-00137422": "If the Stone-city falls, then we shall have  no returning.", "izt-72nTIhc-00327-00137424-00137838": "If it is saved, then the orc-host itself  will be cut off.", "izt-72nTIhc-00328-00137854-00138276": "If you are faithful, Ghân-buri-Ghân, then we will give you rich reward,", "izt-72nTIhc-00329-00138276-00138654": "and you shall have the friendship of the Mark for ever.”", "izt-72nTIhc-00330-00138764-00139298": "Théoden led a new ride of the Rohirrim, who fought bravely in the Fields of Pelennor.", "izt-72nTIhc-00331-00139328-00139913": "[The Return of the King  – The Ride of the Rihirrim]", "izt-72nTIhc-00332-00139960-00140314": "“Now is the hour come, Riders of the Mark, sons of Eorl!", "izt-72nTIhc-00333-00140314-00140772": "Foes and fire are before you,  and your homes far behind.", "izt-72nTIhc-00334-00140780-00141128": "Yet, though you fight upon an alien field,", "izt-72nTIhc-00335-00141128-00141412": "the glory that you reap there shall be your own for ever.", "izt-72nTIhc-00336-00141424-00142080": "Oaths ye have taken: now fulfil them all, to lord and land and league of friendship!\"", "izt-72nTIhc-00337-00142140-00142410": "Men clashed spear upon shield.", "izt-72nTIhc-00338-00142420-00142864": "“Éomer, my son! You lead the first éored”, said Théoden;", "izt-72nTIhc-00339-00142866-00143160": "“and it shall go behind the king's banner  in the centre.", "izt-72nTIhc-00340-00143160-00143606": "Elfhelm, lead your company to the right when we pass the wall.", "izt-72nTIhc-00341-00143670-00144188": "And Grimbold shall lead his towards the left. Let the other companies behind", "izt-72nTIhc-00342-00144190-00144390": "follow these three that lead,  as they have chance.", "izt-72nTIhc-00343-00144394-00144884": "Strike wherever the enemy gathers.  Other plans we cannot make,", "izt-72nTIhc-00344-00144884-00145168": "for we know not yet how things stand upon the field.", "izt-72nTIhc-00345-00145168-00145498": "Forth now, and fear no darkness!”", "izt-72nTIhc-00346-00145644-00145921": "It was in Pelennor  where ended the King’s life,", "izt-72nTIhc-00347-00145921-00146176": "at the same time that his niece Éowyn reveals herself", "izt-72nTIhc-00348-00146176-00146554": "and with the aid of the hobbit Merry, destroys the Witch King of Angmar,", "izt-72nTIhc-00349-00146554-00146744": "Nazgul’s Leader.", "izt-72nTIhc-00350-00146744-00147057": "You may find out more about this  in the TT #64,", "izt-72nTIhc-00351-00147057-00147257": "whose link also here below the video description.", "izt-72nTIhc-00352-00147444-00147781": "After the War of the Ring, the oath  of allegiance between Rohan", "izt-72nTIhc-00353-00147781-00147942": "and Gondor is renewed,", "izt-72nTIhc-00354-00147942-00148360": "and the King Éomer became partner of  the King Elessar, in charges in east and", "izt-72nTIhc-00355-00148360-00148476": "in the south of the Middle-earth.", "izt-72nTIhc-00356-00148476-00148890": "Éomer marries with Lothíriel, daughter  of the Prince Imrahil of Dol Amroth,", "izt-72nTIhc-00357-00148890-00149113": "and to them is born Elfwine.", "izt-72nTIhc-00358-00149250-00149786": "So, that is it folks! Today we have a brief overview of Rohan, Rohirrim’s history,", "izt-72nTIhc-00359-00149796-00150260": "their migration from north to south, their battles and allegiances with Gondor.", "izt-72nTIhc-00360-00150314-00150530": "There are still more to talk about:", "izt-72nTIhc-00361-00150548-00151186": "of Helm’s Deep, of Kings, of Théoden, Éomer, Éowyn, Helm Hammerhand…", "izt-72nTIhc-00362-00151206-00151508": "All of this we will still talk about here  in Tolkien Talk.", "izt-72nTIhc-00363-00151576-00162993": "[Messages]", "izt-72nTIhc-00369-00165116-00165544": "I hope you enjoyed the video, so, do not forget to give that like,", "izt-72nTIhc-00370-00165544-00165878": "and also comment  on what do you think about the Riders of Rohan.", "izt-72nTIhc-00371-00165920-00166327": "Subscribe here in the TT and help the channel growing by spreading", "izt-72nTIhc-00372-00166327-00166447": "for your friends.", "izt-72nTIhc-00373-00166447-00167086": "It is always a pleasure to talk about Tolkien with you. So, until the next video. Bye!", "izt-72nTIhc-00374-00167086-00167734": "Diego Pascoal"}}, {"audio_id": "iz_jNCfbFiY", "text": {"iz_jNCfbFiY-00000-00000840-00001340": "I'm talking like 3 months ago! Sorry!", "iz_jNCfbFiY-00001-00006859-00007359": "Here", "iz_jNCfbFiY-00002-00010360-00010860": "Can't touch this!", "iz_jNCfbFiY-00003-00011410-00011910": "Actually I do crazy \"narration\" ;)"}}, {"audio_id": "i-26xxUwbB8", "text": {"i-26xxUwbB8-00000-00000003-00000608": "so Logan Paul went to the Japanese suicide forest and he was cracking jokes", "i-26xxUwbB8-00001-00000608-00001130": "and we need to talk about it so stay tuned what's up everybody this is Chris", "i-26xxUwbB8-00002-00001130-00001529": "from the rewired soul where we talk about the problem but focus on the", "i-26xxUwbB8-00003-00001529-00002085": "solution our New Year's Eve Logan Paul posted a video he's been in Japan doing", "i-26xxUwbB8-00004-00002085-00002393": "some vlogs he's not somebody I follow but this news has been popping up", "i-26xxUwbB8-00005-00002393-00002847": "everywhere and apparently while in Japan he went to the Japanese suicide forest", "i-26xxUwbB8-00006-00002847-00003402": "and this is a forest in Japan and I'm not going to even try to butcher the", "i-26xxUwbB8-00007-00003402-00003882": "name this is a forest in Japan and it's known as the suicide for us now Japan", "i-26xxUwbB8-00008-00003882-00004514": "has a long history of suicides they they view suicide a little bit differently in", "i-26xxUwbB8-00009-00004514-00005003": "their culture dating back to the samurai days it's looked at as an honorable", "i-26xxUwbB8-00010-00005003-00005537": "death to some but there's also you know the rise of mental illness almost like", "i-26xxUwbB8-00011-00005537-00005991": "there is anywhere else in the world we live in a you know a time where mental", "i-26xxUwbB8-00012-00005991-00006437": "illness is a big problem and we need to start looking at it differently that's", "i-26xxUwbB8-00013-00006437-00006884": "one of the reasons why I have this channel but anyways the video that Logan", "i-26xxUwbB8-00014-00006884-00007479": "Paul posted is now down a lot of other youtubers have been covering this and I", "i-26xxUwbB8-00015-00007479-00007818": "would feel remiss if I didn't talk about it because my channel is about mental", "i-26xxUwbB8-00016-00007818-00008247": "health so basically I'll just give you the recap from what else I've seen I'll", "i-26xxUwbB8-00017-00008247-00008586": "link to another video that I watched that pulled some clips before we took it", "i-26xxUwbB8-00018-00008586-00009111": "down anyways Logan Paul starts off with a little disclaimer which I'll get back", "i-26xxUwbB8-00019-00009111-00009525": "to in a second and it says like hey if you're depressed to go get help", "i-26xxUwbB8-00020-00009525-00010104": "but anyways in Japan they they go to this suicide for us just to check it out", "i-26xxUwbB8-00021-00010104-00010575": "and you know have a good time that's what they planned on doing and as they", "i-26xxUwbB8-00022-00010575-00010929": "were walking through the forest they actually found a man who had hung", "i-26xxUwbB8-00023-00010929-00011482": "himself now in this forest most of the people who go there they hang themselves", "i-26xxUwbB8-00024-00011482-00011907": "either that or they poison themselves a lot of them will go there and overdose", "i-26xxUwbB8-00025-00011907-00012290": "on drugs on average they don't have an exact", "i-26xxUwbB8-00026-00012290-00012632": "count but on average they say about a hundred people commit suicide in this", "i-26xxUwbB8-00027-00012632-00013303": "forest each year in 2008 when the market crashed in one month alone", "i-26xxUwbB8-00028-00013303-00013881": "they had about 2,500 deaths now when Logan Paul and his little crew of", "i-26xxUwbB8-00029-00013881-00014605": "whoever went in there like it was it was like a messed up stupid version of like", "i-26xxUwbB8-00030-00014605-00015181": "stand by me and it was it was kind of ridiculous and I was just really getting", "i-26xxUwbB8-00031-00015181-00015591": "upset just seeing the dumb looks on their faces of trying not to smile and", "i-26xxUwbB8-00032-00015591-00016081": "not knowing like how to react and then Logan Paul like cracking a few jokes and", "i-26xxUwbB8-00033-00016081-00016555": "things like that and it's it's it's really brutal just saying that and", "i-26xxUwbB8-00034-00016555-00016876": "here's the issue that I take with that like a lot of people are just heated", "i-26xxUwbB8-00035-00016876-00017332": "about it for like you know obvious reasons obvious reasons here's my issue", "i-26xxUwbB8-00036-00017332-00017656": "there there's a lot of people in celebrity culture like if any of you", "i-26xxUwbB8-00037-00017656-00017995": "watch my video about Carrie Fisher and her passing away Carrie Fisher was a", "i-26xxUwbB8-00038-00017995-00018351": "huge mental health advocate because she struggled with mental illness as well as", "i-26xxUwbB8-00039-00018351-00018853": "drug addiction things like that I'm a fan even if I'm not a fan of their work", "i-26xxUwbB8-00040-00018853-00019294": "I'm a fan of any celebrity who uses their voice to try to help people", "i-26xxUwbB8-00041-00019294-00019744": "struggling with mental illness or addiction so you have like people like", "i-26xxUwbB8-00042-00019744-00020248": "Eminem and Macklemore and Matthew Perry and Robert Downey jr. he's due here he's", "i-26xxUwbB8-00043-00020248-00020710": "talked openly about it too and so let's start out by talking about that", "i-26xxUwbB8-00044-00020710-00021151": "disclaimer that Logan Paul tossed up in the beginning it was a video it was", "i-26xxUwbB8-00045-00021151-00021532": "pretty brutal it was nothing there was no resources or", "i-26xxUwbB8-00046-00021532-00022000": "anything here in the United States where Logan Paul is from we have a national", "i-26xxUwbB8-00047-00022000-00022615": "suicide hotline as well as a text line it is a line that I give to people all", "i-26xxUwbB8-00048-00022615-00023050": "the time if they are suicidal and I will link in the description down below to", "i-26xxUwbB8-00049-00023050-00023701": "both those numbers if you need it or you need to relay it to a loved one but like", "i-26xxUwbB8-00050-00023701-00024160": "I get it and like what's what's frustrating is he took the video down", "i-26xxUwbB8-00051-00024160-00024598": "but he only took the video down because of the backlash that was it only because", "i-26xxUwbB8-00052-00024598-00024865": "of the backlash and that's kind of a thing that you find in the YouTube", "i-26xxUwbB8-00053-00024865-00025117": "community now screw it not even the YouTube", "i-26xxUwbB8-00054-00025117-00025632": "community like just in pop culture in general people are only apologetic after", "i-26xxUwbB8-00055-00025632-00025983": "they get in trouble for it had he not got the backlash from it I", "i-26xxUwbB8-00056-00025983-00026314": "would assume that he'd go the rest of his life not knowing that he did", "i-26xxUwbB8-00057-00026314-00026666": "anything and well what I don't get what imma get", "i-26xxUwbB8-00058-00026666-00027125": "about this situation is it's like sometimes there's smaller youtubers who", "i-26xxUwbB8-00059-00027125-00027767": "have to Nate didn't know they don't have to they want to okay they they want to", "i-26xxUwbB8-00060-00027767-00028208": "get more views and they do some really shady and really stupid stuff but logan", "i-26xxUwbB8-00061-00028208-00028583": "paul is like synonymous with youtube he's one of the biggest youtubers on the", "i-26xxUwbB8-00062-00028583-00029042": "platform along with his brother i you don't need to do scummy things in order", "i-26xxUwbB8-00063-00029042-00029552": "to get views like you don't have to the views are already there you know and and", "i-26xxUwbB8-00064-00029552-00030023": "yeah it's just it's just crazy but you know the last thing i'll touch on is", "i-26xxUwbB8-00065-00030023-00030287": "like this is one of the reasons why there's such a stigma about it too", "i-26xxUwbB8-00066-00030287-00031007": "because Logan Logan Paul and his brother they their audience is like you know", "i-26xxUwbB8-00067-00031007-00031516": "just the most average random person it's a lot of kids and things like that and", "i-26xxUwbB8-00068-00031516-00031907": "you know they're they're not doing anything to help the next generation", "i-26xxUwbB8-00069-00031907-00032189": "when it comes to talking about mental illness talking about drug addiction", "i-26xxUwbB8-00070-00032189-00032729": "talking about these very serious things so when when someone that big uses their", "i-26xxUwbB8-00071-00032729-00033131": "voice in a negative way like this it's it's pretty troubling you know what I", "i-26xxUwbB8-00072-00033131-00033719": "mean but but anyways I do you know mental health advocacy on this channel I", "i-26xxUwbB8-00073-00033719-00034115": "do mental health news on this channel so I thought I would give you my two cents", "i-26xxUwbB8-00074-00034115-00034610": "on this Logan Paul situation anyways if you like this video please give it a", "i-26xxUwbB8-00075-00034610-00034928": "thumbs up and again check the description down below if you or", "i-26xxUwbB8-00076-00034928-00035333": "somebody you know is suicidal please check out those numbers give them to", "i-26xxUwbB8-00077-00035333-00035858": "whoever needs them alright but thanks for watching if you want to improve your", "i-26xxUwbB8-00078-00035858-00036182": "mental health I talk about mental illness I talk about addiction recovery", "i-26xxUwbB8-00079-00036182-00036554": "so hit that little round subscribe button also to the left of me right", "i-26xxUwbB8-00080-00036554-00036833": "there click or tap on one of the thumbnails check out some of the other", "i-26xxUwbB8-00081-00036833-00037372": "videos on this channel thanks so much for watching I'll see you next time"}}, {"audio_id": "i_n79V4DPfc", "text": {"i_n79V4DPfc-00000-00001256-00001864": "hi guys good morning good morning good morning welcome welcome welcome to this new episode", "i_n79V4DPfc-00001-00001936-00002704": "of our vlog welcome again to Vayouth Episode! so far Dzai, yeah so we're dying", "i_n79V4DPfc-00002-00002816-00003447": "how is your feeling how do you feel? i'm about how do you feel uh relaxed or impressed", "i_n79V4DPfc-00003-00003447-00004208": "thank you so much for the i know sleepover enjoy your company i enjoyed a lot of my baby friends", "i_n79V4DPfc-00004-00004208-00004576": "and there's a branch out but that's all my friends who's friends", "i_n79V4DPfc-00005-00005176-00005784": "thank you so much", "i_n79V4DPfc-00006-00012288-00012720": "but again welcome to our humble abode thank", "i_n79V4DPfc-00007-00018160-00018384": "oh my god", "i_n79V4DPfc-00008-00025232-00025384": "hello", "i_n79V4DPfc-00009-00026536-00026783": "um", "i_n79V4DPfc-00010-00028064-00028183": "um", "i_n79V4DPfc-00011-00030527-00030983": "on", "i_n79V4DPfc-00012-00032152-00032383": "m", "i_n79V4DPfc-00013-00033544-00033784": "foreign", "i_n79V4DPfc-00014-00034968-00035184": "oh", "i_n79V4DPfc-00015-00043064-00043584": "thank you", "i_n79V4DPfc-00016-00046344-00046976": "thank you so much for support i was trying nothing to feel good supervisor", "i_n79V4DPfc-00017-00047488-00047784": "online", "i_n79V4DPfc-00018-00051279-00051984": "um", "i_n79V4DPfc-00019-00054472-00054784": "oh", "i_n79V4DPfc-00020-00061255-00061784": "airport", "i_n79V4DPfc-00021-00066960-00067384": "foreign", "i_n79V4DPfc-00022-00071264-00071584": "no", "i_n79V4DPfc-00023-00074280-00074384": "girls", "i_n79V4DPfc-00024-00079776-00079984": "hmm", "i_n79V4DPfc-00025-00088000-00088384": "um", "i_n79V4DPfc-00026-00089544-00089784": "career", "i_n79V4DPfc-00027-00090168-00091184": "hi this year", "i_n79V4DPfc-00028-00091816-00092584": "so", "i_n79V4DPfc-00029-00095232-00095384": "is", "i_n79V4DPfc-00030-00096272-00096496": "oh"}}, {"audio_id": "i_S8BNFfoCU", "text": {"i_S8BNFfoCU-00000-00000012-00000144": "wave electric bike waves", "i_S8BNFfoCU-00001-00000144-00000249": "wave terrible bike", "i_S8BNFfoCU-00002-00000249-00000352": "wave terrible bike", "i_S8BNFfoCU-00003-00000352-00000509": "terrible wave bike wave bike", "i_S8BNFfoCU-00004-00000509-00000639": "wave wave wave electric bike", "i_S8BNFfoCU-00005-00000639-00000859": "as a bike cheap plastic", "i_S8BNFfoCU-00006-00000859-00001001": "horn squeeky", "i_S8BNFfoCU-00007-00001001-00001101": "broken crack", "i_S8BNFfoCU-00008-00001101-00001267": "useless in the way", "i_S8BNFfoCU-00009-00001267-00001512": "25 cents not street legal", "i_S8BNFfoCU-00010-00001512-00001782": "and the complaints don't end there for some reason", "i_S8BNFfoCU-00011-00001782-00001952": "cheap bike wooow", "i_S8BNFfoCU-00012-00001952-00002127": "angry comments had some issues", "i_S8BNFfoCU-00013-00002127-00002442": "alternative facts ebike bike bike", "i_S8BNFfoCU-00014-00002442-00002542": "bicycle bike", "i_S8BNFfoCU-00015-00002542-00002695": "a lady wave disturbing", "i_S8BNFfoCU-00016-00002695-00002923": "wave broadband wave bike", "i_S8BNFfoCU-00017-00002923-00003157": "wave wave and wave wave wave", "i_S8BNFfoCU-00018-00003157-00003294": "bicycle wave bike", "i_S8BNFfoCU-00019-00003294-00003394": "bicycles wave wave", "i_S8BNFfoCU-00020-00003394-00003521": "wave cheap bike", "i_S8BNFfoCU-00021-00003521-00003658": "wave lady wave bikes", "i_S8BNFfoCU-00022-00003658-00003778": "wave bike ebikes", "i_S8BNFfoCU-00023-00003778-00004007": "a regular bike bikes bike bike", "i_S8BNFfoCU-00024-00004007-00004216": "like dislike hyeah", "i_S8BNFfoCU-00025-00004216-00004348": "freshbook"}}, {"audio_id": "iA70Dn3DBE4", "text": {"iA70Dn3DBE4-00000-00000000-00000326": "hello This is Dream Interpretation TV", "iA70Dn3DBE4-00001-00000326-00000609": "Today we will tell you about the dream of stealing", "iA70Dn3DBE4-00002-00000609-00000916": "Stealing related dreams in audiobook format", "iA70Dn3DBE4-00003-00000916-00001055": "I plan to read it", "iA70Dn3DBE4-00004-00001055-00001432": "Listen to it and compare it to the dream you had last night", "iA70Dn3DBE4-00005-00001432-00001653": "Please try to interpret the dream", "iA70Dn3DBE4-00006-00001653-00001934": "For more details, check the More section", "iA70Dn3DBE4-00007-00001934-00002270": "If you have any questions, please ask in the comments", "iA70Dn3DBE4-00008-00002270-00002469": "And please subscribe and like", "iA70Dn3DBE4-00009-00002469-00002551": "thank you", "iA70Dn3DBE4-00010-00002551-00002834": "Secretly stealing some of the money in the bag", "iA70Dn3DBE4-00011-00002834-00003211": "If you dream of secretly stealing some of the money in your bag,", "iA70Dn3DBE4-00012-00003211-00003869": "it will be misunderstood as unofficial money and embezzlement of public funds or joint responsibility will occur", "iA70Dn3DBE4-00013-00003869-00004104": "Dream of stealing precious metals", "iA70Dn3DBE4-00014-00004104-00004313": "Receive and bring the price paid", "iA70Dn3DBE4-00015-00004313-00004539": "The wife and the new wife are pregnant", "iA70Dn3DBE4-00016-00004539-00004885": "Dream of stealing gold silver jewelry and valuables", "iA70Dn3DBE4-00017-00004885-00005679": "A dream in which you see that you are stealing jewels or valuables from somewhere is a dream that suggests that your economic power is deteriorating", "iA70Dn3DBE4-00018-00005679-00006322": "If you are pursuing something new, it might be a good idea to stop for a while and look at your financial situation", "iA70Dn3DBE4-00019-00006322-00007112": "Even if the loan was promised, there is a risk that it will suddenly be blocked, so it is good to review it carefully as if knocking on a stone bridge", "iA70Dn3DBE4-00020-00007112-00007412": "Secretly Stealing Gold and Silver Treasures", "iA70Dn3DBE4-00021-00007412-00007791": "You will have a lot of wealth and money, and you will have plenty to eat", "iA70Dn3DBE4-00022-00007791-00008134": "Pregnancy, windfall, possession, etc", "iA70Dn3DBE4-00023-00008134-00008429": "I saw stealing things with my hands in a dream", "iA70Dn3DBE4-00024-00008429-00008842": "Your property or rights will be stolen or you will fall into a trap", "iA70Dn3DBE4-00025-00008842-00009015": "Secret stealing dream", "iA70Dn3DBE4-00026-00009015-00009495": "We exercise our skills to satisfy the desires that spring from our hearts", "iA70Dn3DBE4-00027-00009495-00009764": "Dream of stealing someone else's cocoon", "iA70Dn3DBE4-00028-00009764-00010266": "Lost money and property are recovered, and the pregnant woman gives birth to a son", "iA70Dn3DBE4-00029-00010266-00010460": "Stealing other people's things", "iA70Dn3DBE4-00030-00010460-00011084": "If you dream of stealing other people's things, you will do your best to do something that no one will help you or allow", "iA70Dn3DBE4-00031-00011084-00011278": "Stealing someone else's cow", "iA70Dn3DBE4-00032-00011278-00011705": "Get married or get pregnant, have fun with Hapgung, etc", "iA70Dn3DBE4-00033-00011705-00012024": "Stealing precious metals from someone else's house", "iA70Dn3DBE4-00034-00012024-00012233": "Receive and bring the price paid", "iA70Dn3DBE4-00035-00012233-00012459": "The wife and the new wife are pregnant", "iA70Dn3DBE4-00036-00012459-00012749": "Secretly Stealing Other Books or Documents", "iA70Dn3DBE4-00037-00012749-00013222": "Fame and riches prosper along with the achievement of the purpose or wish sought", "iA70Dn3DBE4-00038-00013222-00013580": "Secretly Stealing Chemical Fertilizer from Rice Field", "iA70Dn3DBE4-00039-00013580-00014097": "A sign that you will do something dishonest, such as plagiarizing other people's knowledge", "iA70Dn3DBE4-00040-00014097-00014280": "Stealing someone's property", "iA70Dn3DBE4-00041-00014280-00014887": "If you dream of stealing someone's goods, you will succeed in a difficult matter, even if it is difficult", "iA70Dn3DBE4-00042-00014887-00015043": "Dream of Stealing Money", "iA70Dn3DBE4-00043-00015043-00015544": "Interpretation of dreams related to money is important to understand the symbols", "iA70Dn3DBE4-00044-00015544-00015761": "Money symbolizes your desires", "iA70Dn3DBE4-00045-00015761-00016380": "If you dream of stealing money from someone you know, it is likely that you will have a bad relationship with that person", "iA70Dn3DBE4-00046-00016380-00016814": "If you steal money from someone you don't know, chances are you'll lose your money", "iA70Dn3DBE4-00047-00016814-00016970": "Dream of Stealing Money", "iA70Dn3DBE4-00048-00016970-00017196": "It's a dream that happy things will happen", "iA70Dn3DBE4-00049-00017196-00017383": "Dream about stealing something", "iA70Dn3DBE4-00050-00017383-00017755": "It represents the desire to steal love, power, etc", "iA70Dn3DBE4-00051-00017755-00017853": "from someone", "iA70Dn3DBE4-00052-00017853-00018112": "Dream of seeing hands stealing things", "iA70Dn3DBE4-00053-00018112-00018383": "Actually, goods, rights, etc", "iA70Dn3DBE4-00054-00018383-00018527": "are stolen or framed", "iA70Dn3DBE4-00055-00018527-00018959": "Dream of stealing a painting of a beautiful woman from an art gallery", "iA70Dn3DBE4-00056-00018959-00019552": "They meet people by chance in cultural spaces or meeting squares, form bonds, and fall in love", "iA70Dn3DBE4-00057-00019552-00020138": "Windfall, riches, money, acquisition of documents, events, etc", "iA70Dn3DBE4-00058-00020138-00020232": "will occur", "iA70Dn3DBE4-00059-00020232-00020590": "To dream of taking or stealing the other person's livestock", "iA70Dn3DBE4-00060-00020590-00021317": "If you dream of taking or stealing the other person's livestock, you will do something and attract property and people to your side", "iA70Dn3DBE4-00061-00021317-00021473": "Cow Stealing Dream", "iA70Dn3DBE4-00062-00021473-00022047": "If you dream of stealing a cow, you will acquire a lot of wealth, get married or become pregnant", "iA70Dn3DBE4-00063-00022047-00022369": "Dream of seeing someone stealing things with their hands", "iA70Dn3DBE4-00064-00022369-00022734": "Having your property or rights stolen or falling into a trap", "iA70Dn3DBE4-00065-00022734-00022864": "Stealing something", "iA70Dn3DBE4-00066-00022864-00023608": "The dream of stealing something implies that you will actually get something, and the rights or status you will get will vary depending on the thing", "iA70Dn3DBE4-00067-00023608-00024275": "If you steal jewels, you may rise to a high position in a company or institution, or you may get a good spouse", "iA70Dn3DBE4-00068-00024275-00024621": "Stealing livestock will bring you new wealth or people's work", "iA70Dn3DBE4-00069-00024621-00024943": "To dream of pickpocketing or seeing thieves stealing", "iA70Dn3DBE4-00070-00024943-00025505": "Unexpected wealth or interest will arise, or the pleasure of meeting nobles will arise", "iA70Dn3DBE4-00071-00025505-00025802": "Secretly Stealing Ripe and Unripe Fruits", "iA70Dn3DBE4-00072-00025802-00026369": "If you dream of secretly stealing ripe and unripe fruits, you will get married through a matchmaker", "iA70Dn3DBE4-00073-00026369-00026483": "Stealing a car", "iA70Dn3DBE4-00074-00026483-00026845": "If you dream of stealing a car, your luck will decline", "iA70Dn3DBE4-00075-00026845-00027319": "There is a possibility of a lower position in the company or in the work you do", "iA70Dn3DBE4-00076-00027319-00027664": "In the case of students, grades are likely to be poor", "iA70Dn3DBE4-00077-00027664-00027948": "Dream of a maiden getting or stealing a vase", "iA70Dn3DBE4-00078-00027948-00028152": "You will marry the man you admire", "iA70Dn3DBE4-00079-00028152-00028282": "Stealing Grapes", "iA70Dn3DBE4-00080-00028282-00028882": "With the conception dream, the wife and new wife become pregnant and give birth to a wonderful child", "iA70Dn3DBE4-00081-00028882-00029794": "There are real estate ownership, windfall, wealth, money, goods, food, passing, winning, qualifications, etc", "iA70Dn3DBE4-00082-00029794-00030022": "Stealing Blue and Yellow Fruits", "iA70Dn3DBE4-00083-00030022-00030427": "This dream foreshadows that marriage will be established through a mediator"}}, {"audio_id": "iAf2Ov-g8zU", "text": {"iAf2Ov-g8zU-00000-00000010-00000547": "TO AFFECTED COMMUNITIES.", "iAf2Ov-g8zU-00001-00000547-00000553": "TO AFFECTED COMMUNITIES.", "iAf2Ov-g8zU-00002-00000553-00000653": "TO AFFECTED COMMUNITIES. >> DENNIS: STATE AUTHORITIES ARE", "iAf2Ov-g8zU-00003-00000653-00000660": "TO AFFECTED COMMUNITIES. >> DENNIS: STATE AUTHORITIES ARE", "iAf2Ov-g8zU-00004-00000660-00000730": "TO AFFECTED COMMUNITIES. >> DENNIS: STATE AUTHORITIES ARE OFFERING A REWARD FOR", "iAf2Ov-g8zU-00005-00000730-00000737": ">> DENNIS: STATE AUTHORITIES ARE OFFERING A REWARD FOR", "iAf2Ov-g8zU-00006-00000737-00000820": ">> DENNIS: STATE AUTHORITIES ARE OFFERING A REWARD FOR INFORMATION IN THE DEATH OF A", "iAf2Ov-g8zU-00007-00000820-00000827": "OFFERING A REWARD FOR INFORMATION IN THE DEATH OF A", "iAf2Ov-g8zU-00008-00000827-00000960": "OFFERING A REWARD FOR INFORMATION IN THE DEATH OF A NORTHERN MINNESOTA MAN KILLED IN", "iAf2Ov-g8zU-00009-00000960-00000967": "INFORMATION IN THE DEATH OF A NORTHERN MINNESOTA MAN KILLED IN", "iAf2Ov-g8zU-00010-00000967-00001091": "INFORMATION IN THE DEATH OF A NORTHERN MINNESOTA MAN KILLED IN HIS HOME LAST YEAR.", "iAf2Ov-g8zU-00011-00001091-00001097": "NORTHERN MINNESOTA MAN KILLED IN HIS HOME LAST YEAR.", "iAf2Ov-g8zU-00012-00001097-00001241": "NORTHERN MINNESOTA MAN KILLED IN HIS HOME LAST YEAR. 60-YEAR-OLD BRIAN JOSEPH NELSON", "iAf2Ov-g8zU-00013-00001241-00001247": "HIS HOME LAST YEAR. 60-YEAR-OLD BRIAN JOSEPH NELSON", "iAf2Ov-g8zU-00014-00001247-00001391": "HIS HOME LAST YEAR. 60-YEAR-OLD BRIAN JOSEPH NELSON WAS STABBED AND FOUND DEAD IN", "iAf2Ov-g8zU-00015-00001391-00001398": "60-YEAR-OLD BRIAN JOSEPH NELSON WAS STABBED AND FOUND DEAD IN", "iAf2Ov-g8zU-00016-00001398-00001591": "60-YEAR-OLD BRIAN JOSEPH NELSON WAS STABBED AND FOUND DEAD IN HIS HOUSE BEHIND THE BOTTLE SHOP", "iAf2Ov-g8zU-00017-00001591-00001598": "WAS STABBED AND FOUND DEAD IN HIS HOUSE BEHIND THE BOTTLE SHOP", "iAf2Ov-g8zU-00018-00001598-00001745": "WAS STABBED AND FOUND DEAD IN HIS HOUSE BEHIND THE BOTTLE SHOP LIQUOR STORE LAST JULY IN", "iAf2Ov-g8zU-00019-00001745-00001751": "HIS HOUSE BEHIND THE BOTTLE SHOP LIQUOR STORE LAST JULY IN", "iAf2Ov-g8zU-00020-00001751-00001831": "HIS HOUSE BEHIND THE BOTTLE SHOP LIQUOR STORE LAST JULY IN HIBBING.", "iAf2Ov-g8zU-00021-00001831-00001838": "LIQUOR STORE LAST JULY IN HIBBING.", "iAf2Ov-g8zU-00022-00001838-00001958": "LIQUOR STORE LAST JULY IN HIBBING. THE MINNESOTA BUREAU OF CRIMINAL", "iAf2Ov-g8zU-00023-00001958-00001965": "HIBBING. THE MINNESOTA BUREAU OF CRIMINAL", "iAf2Ov-g8zU-00024-00001965-00002072": "HIBBING. THE MINNESOTA BUREAU OF CRIMINAL APPREHENSION SAID THURSDAY IT", "iAf2Ov-g8zU-00025-00002072-00002078": "THE MINNESOTA BUREAU OF CRIMINAL APPREHENSION SAID THURSDAY IT", "iAf2Ov-g8zU-00026-00002078-00002365": "THE MINNESOTA BUREAU OF CRIMINAL APPREHENSION SAID THURSDAY IT WILL PAY $25,000 FOR INFORMATION", "iAf2Ov-g8zU-00027-00002365-00002372": "APPREHENSION SAID THURSDAY IT WILL PAY $25,000 FOR INFORMATION", "iAf2Ov-g8zU-00028-00002372-00002555": "APPREHENSION SAID THURSDAY IT WILL PAY $25,000 FOR INFORMATION THAT MOVES THE CASE FORWARD.", "iAf2Ov-g8zU-00029-00002555-00002562": "WILL PAY $25,000 FOR INFORMATION THAT MOVES THE CASE FORWARD.", "iAf2Ov-g8zU-00030-00002562-00002746": "WILL PAY $25,000 FOR INFORMATION THAT MOVES THE CASE FORWARD. NELSON WAS A LONG-TIME HIBBING", "iAf2Ov-g8zU-00031-00002746-00002752": "THAT MOVES THE CASE FORWARD. NELSON WAS A LONG-TIME HIBBING", "iAf2Ov-g8zU-00032-00002752-00002906": "THAT MOVES THE CASE FORWARD. NELSON WAS A LONG-TIME HIBBING RESIDENT AND OWNED THE LIQUOR", "iAf2Ov-g8zU-00033-00002906-00002912": "NELSON WAS A LONG-TIME HIBBING RESIDENT AND OWNED THE LIQUOR", "iAf2Ov-g8zU-00034-00002912-00002972": "NELSON WAS A LONG-TIME HIBBING RESIDENT AND OWNED THE LIQUOR STORE.", "iAf2Ov-g8zU-00035-00002972-00002979": "RESIDENT AND OWNED THE LIQUOR STORE.", "iAf2Ov-g8zU-00036-00002979-00003206": "RESIDENT AND OWNED THE LIQUOR STORE. POLICE BELIEVE NELSON WAS KILLED", "iAf2Ov-g8zU-00037-00003206-00003213": "STORE. POLICE BELIEVE NELSON WAS KILLED", "iAf2Ov-g8zU-00038-00003213-00003386": "STORE. POLICE BELIEVE NELSON WAS KILLED SOMETIME BETWEEN 10:30 P.M.", "iAf2Ov-g8zU-00039-00003386-00003393": "POLICE BELIEVE NELSON WAS KILLED SOMETIME BETWEEN 10:30 P.M.", "iAf2Ov-g8zU-00040-00003393-00003630": "POLICE BELIEVE NELSON WAS KILLED SOMETIME BETWEEN 10:30 P.M. JULY 8th AND JULY 10th.", "iAf2Ov-g8zU-00041-00003630-00003636": "SOMETIME BETWEEN 10:30 P.M. JULY 8th AND JULY 10th.", "iAf2Ov-g8zU-00042-00003636-00003757": "SOMETIME BETWEEN 10:30 P.M. JULY 8th AND JULY 10th. AUTHORITIES HAVE MADE NO ARRESTS"}}, {"audio_id": "iAf_9toJn2A", "text": {"iAf_9toJn2A-00000-00000000-00000200": "MOON RITUALS???"}}, {"audio_id": "iAvaIYhUZkY", "text": {"iAvaIYhUZkY-00000-00000000-00004800": "🌟 🇺🇸 Suit Lemon Children's — Shop GrandStart.ru 🌟"}}, {"audio_id": "iAG7WjkPOwA", "text": {"iAG7WjkPOwA-00000-00000446-00000883": "Often the actual writing is the hardest part of a research paper.", "iAG7WjkPOwA-00001-00000883-00001409": "This short video will share tips to help make the process go more smoothly.", "iAG7WjkPOwA-00002-00001410-00001540": "Before you start:", "iAG7WjkPOwA-00003-00001540-00001933": "Give yourself more time than you think you need and don’t procrastinate.", "iAG7WjkPOwA-00004-00001933-00002426": "Make sure you set aside some uninterrupted time to focus on your writing.", "iAG7WjkPOwA-00005-00002426-00002683": "Limit distractions as much as possible.", "iAG7WjkPOwA-00006-00002683-00003243": "Turn your phone off or put it away. Turn off the TV or other distractions.", "iAG7WjkPOwA-00007-00003243-00003933": "Also take the time to reread your assignment. Make sure you don’t miss any of the requirements.", "iAG7WjkPOwA-00008-00003933-00004439": "Writing may seem like a linear process, but it can be messy and fluid.", "iAG7WjkPOwA-00009-00004440-00004930": "You may need to reorganize your outline, move the paragraphs around,", "iAG7WjkPOwA-00010-00004930-00005330": "revise your thesis statement, or change the direction of your paper.", "iAG7WjkPOwA-00011-00005330-00005916": "Make sure that any changes are supported by evidence in a logical and clear manner.", "iAG7WjkPOwA-00012-00005916-00006059": "Just start writing!", "iAG7WjkPOwA-00013-00006060-00006300": "You do not need to start at the beginning.", "iAG7WjkPOwA-00014-00006300-00006766": "You can write your introduction later when your overall thoughts are more clear.", "iAG7WjkPOwA-00015-00006766-00007166": "Start writing where you have ideas and the rest will flow from there.", "iAG7WjkPOwA-00016-00007166-00007713": "The writing process is one of constant revision and you will get better at it the more you practice.", "iAG7WjkPOwA-00017-00007713-00008179": "Getting your ideas down on paper is the most important part of your first draft.", "iAG7WjkPOwA-00018-00008180-00008756": "So long as you give yourself time for revision, you can always fix up some of the messier sections later.", "iAG7WjkPOwA-00019-00008756-00008866": "Take Breaks.", "iAG7WjkPOwA-00020-00008866-00009189": "Take breaks when your brain starts to feel fatigued.", "iAG7WjkPOwA-00021-00009190-00009476": "Take a break after your first draft.", "iAG7WjkPOwA-00022-00009476-00010029": "This way you will return to your writing refreshed and with a new way of looking at things.", "iAG7WjkPOwA-00023-00010030-00010176": "Revising and Editing.", "iAG7WjkPOwA-00024-00010176-00010816": "This process might take some time so make sure you give yourself plenty of time before your paper is due.", "iAG7WjkPOwA-00025-00010816-00011126": "Use a variety of methods for editing and revision.", "iAG7WjkPOwA-00026-00011126-00011526": "You can use the computer, print out your paper and edit by hand,", "iAG7WjkPOwA-00027-00011526-00011989": "read aloud to yourself, and/or have someone look over your paper for you.", "iAG7WjkPOwA-00028-00011990-00012396": "Look over your paper both as a whole and at the micro level.", "iAG7WjkPOwA-00029-00012396-00012946": "Do you have an introduction, body and conclusion? A clear thesis statement?", "iAG7WjkPOwA-00030-00012946-00013696": "Are your paragraphs complete? Are you missing any important information? Are your transitions smooth?", "iAG7WjkPOwA-00031-00013696-00014133": "For smaller things like grammar, it can help to look for one error at a time.", "iAG7WjkPOwA-00032-00014133-00014566": "If you are uncertain of something look it up or ask for help.", "iAG7WjkPOwA-00033-00014566-00014996": "If something seems off to you but you don’t know why, double check.", "iAG7WjkPOwA-00034-00014996-00015359": "CAS is a great resource for help with your writing.", "iAG7WjkPOwA-00035-00015360-00015760": "You can learn more about their services by checking out their website", "iAG7WjkPOwA-00036-00015760-00016420": "www.butte.edu/cas", "iAG7WjkPOwA-00037-00016420-00016933": "The more you practice writing papers the better you will be at the whole process.", "iAG7WjkPOwA-00038-00016933-00017483": "Figure out what works for you and you will soon be an excellent writer of research papers."}}, {"audio_id": "iAGgoN41T7E", "text": {"iAGgoN41T7E-00000-00000082-00000190": "Junior Math Olympiad", "iAGgoN41T7E-00001-00000196-00000288": "The SQUARE", "iAGgoN41T7E-00002-00000288-00000594": "The official Junior Math Olympiad Newsletter", "iAGgoN41T7E-00003-00000612-00000942": "Today, the second video in the series of videos with exercises from the Square #20,", "iAGgoN41T7E-00004-00000942-00001200": "September 2017.", "iAGgoN41T7E-00005-00001200-00001454": "And two more exercises from the front page of", "iAGgoN41T7E-00006-00001454-00001748": "article \"Between Squares\". Exercise four.", "iAGgoN41T7E-00007-00001748-00002104": "State all positive integers \"n\"", "iAGgoN41T7E-00008-00002104-00002408": "for which: number \"n to the power of 4\"", "iAGgoN41T7E-00009-00002408-00002672": "plus 2 times \"n to the power of 3\",", "iAGgoN41T7E-00010-00002672-00002830": "minus 3", "iAGgoN41T7E-00011-00002830-00003050": "is a square of an integer.", "iAGgoN41T7E-00012-00003050-00003515": "Squares of the \"n\" number, in that given number: here to the 4th, here to the 3rd,", "iAGgoN41T7E-00013-00003515-00003914": "suggest that square of the number in the form of", "iAGgoN41T7E-00014-00003920-00004154": "\"n squared\" plus \"n\" may came in handy.", "iAGgoN41T7E-00015-00004198-00004348": "Let's try to \"fit in\"", "iAGgoN41T7E-00016-00004348-00005036": "given number in between the squares of the following integers:", "iAGgoN41T7E-00017-00005036-00005328": "\"n squared\" plus \"n\" minus 1", "iAGgoN41T7E-00018-00005328-00005578": "and \"n squared\" plus \"n\".", "iAGgoN41T7E-00019-00005578-00006114": "For \"n=1\" given number is equal to 0, so it is a square of an integer.", "iAGgoN41T7E-00020-00006148-00006731": "For \"n bigger than 1\" \"n squared plus n minus 1 - all squared\" is given,", "iAGgoN41T7E-00021-00006731-00007002": "it is also possible to multiply this way", "iAGgoN41T7E-00022-00007002-00007248": "and check which one is faster.", "iAGgoN41T7E-00023-00007248-00007359": "We're going to do it this way.", "iAGgoN41T7E-00024-00007384-00007670": "Equals \"n to the power of 4\"", "iAGgoN41T7E-00025-00007698-00007920": "plus 2 times \"n squared\"", "iAGgoN41T7E-00026-00007945-00008352": "times \"n minus 1\" plus \"n minus 1 - squared\".", "iAGgoN41T7E-00027-00008416-00008544": "There is no deep thinking in here,", "iAGgoN41T7E-00028-00008568-00008736": "this equals \"n to the power of 4\"", "iAGgoN41T7E-00029-00008736-00009102": "plus \"2n to the power of 3\" minus \"n squared\"", "iAGgoN41T7E-00030-00009130-00009302": "minus \"2n\" plus 1.", "iAGgoN41T7E-00031-00009344-00009648": "And this is smaller than \"n to the power of 4\"", "iAGgoN41T7E-00032-00009670-00009978": "plus \"2n to the power of 3\" minus 3.", "iAGgoN41T7E-00033-00009994-00010196": "Because \"n squared plus 2n\",", "iAGgoN41T7E-00034-00010222-00010550": "for \"n\" bigger than 1, is bigger or equal to", "iAGgoN41T7E-00035-00010578-00010830": "\"2 squared plus 2 times 2\"", "iAGgoN41T7E-00036-00010856-00011016": "which is bigger than 4.", "iAGgoN41T7E-00037-00011044-00011386": "What is more, \"n to the power of 4\" plus \"2n to the power of 3\"", "iAGgoN41T7E-00038-00011398-00011632": "minus 3 is smaller than", "iAGgoN41T7E-00039-00011644-00011904": "\"n to the power of 4 plus \"2n to the power of 3\"", "iAGgoN41T7E-00040-00011920-00012076": "plus \"n squared\".", "iAGgoN41T7E-00041-00012094-00012324": "And this can be written down in the form of:", "iAGgoN41T7E-00042-00012338-00012592": "\"n squared\" plus \"n\" - all squared", "iAGgoN41T7E-00043-00012614-00012944": "In this case, for \"n\" bigger than 1", "iAGgoN41T7E-00044-00012944-00013121": "these inequalities happen:", "iAGgoN41T7E-00045-00013122-00013580": "\"n to the power of 4\" plus \"2n to the power of 3\" minus 3 is larger than", "iAGgoN41T7E-00046-00013590-00014091": "\"n squared\" plus \"n\" minus 1 - all squared", "iAGgoN41T7E-00047-00014091-00014207": "and is smaller than", "iAGgoN41T7E-00048-00014207-00014474": "\"n squared\" plus \"n\" - all squared.", "iAGgoN41T7E-00049-00014476-00014774": "This means that the number given in the exercise", "iAGgoN41T7E-00050-00014774-00015091": "cannot be a square of an integer.", "iAGgoN41T7E-00051-00015104-00015350": "In the end, we can see that the given number is", "iAGgoN41T7E-00052-00015350-00015713": "a square of an integer only for \"n=1\".", "iAGgoN41T7E-00053-00015713-00015936": "And this sums up the answer to this exercise.", "iAGgoN41T7E-00054-00015936-00016124": "It is not hard to figure out that", "iAGgoN41T7E-00055-00016124-00016510": "the method of \"fitting between\"  can also be used", "iAGgoN41T7E-00056-00016510-00016724": "with other powers, not only squares.", "iAGgoN41T7E-00057-00016736-00016952": "For example: with cubes.", "iAGgoN41T7E-00058-00016952-00017405": "Let's finish with ex.5 on the same page of the 20th \"Square\".", "iAGgoN41T7E-00059-00017406-00017842": "State all (x,y) integers' pairs, for which", "iAGgoN41T7E-00060-00017842-00018060": "the given equation is satisfied:", "iAGgoN41T7E-00061-00018060-00018714": "\"x to the power of 3\" equals \"y to the power of 3\" plus \"2y squared\" plus 1", "iAGgoN41T7E-00062-00018724-00019226": "It has to be noticed that  \"y to the power of 3\" plus \"2y squared\" plus 1", "iAGgoN41T7E-00063-00019226-00019330": "equals", "iAGgoN41T7E-00064-00019330-00019922": "\"y to the power of 3\" plus \"3y squared\" plus \"3y\" plus 1.", "iAGgoN41T7E-00065-00019938-00020188": "This polynomial should already suggest something.", "iAGgoN41T7E-00066-00020188-00020501": "Minus \"y squared\" minus \"3y\"", "iAGgoN41T7E-00067-00020501-00020820": "This equals \"y\" plus 1 to the power of 3,", "iAGgoN41T7E-00068-00020820-00021042": "(now you definitely know what does it suggest)", "iAGgoN41T7E-00069-00021042-00021390": "minus \"y\" times \"y plus 3\".", "iAGgoN41T7E-00070-00021390-00021658": "For any \"y\" number, an inequality occurs:", "iAGgoN41T7E-00071-00021658-00021932": "\"y to the power of 3\" is smaller than", "iAGgoN41T7E-00072-00021932-00022152": "\"y to the power of 3\" plus,", "iAGgoN41T7E-00073-00022152-00022398": "plus any positive number - for example:", "iAGgoN41T7E-00074-00022398-00022678": "plus \"2y squared\" plus 1.", "iAGgoN41T7E-00075-00022678-00022916": "And this is equal to \"x cubed\".", "iAGgoN41T7E-00076-00022916-00023259": "What is more, if \"y\" is smaller or equal to", "iAGgoN41T7E-00077-00023260-00023388": "\"- 4\"", "iAGgoN41T7E-00078-00023388-00023634": "or \"y\" is bigger than 0.", "iAGgoN41T7E-00079-00023634-00024342": "the number \"y times y plus 3\" is positive  as a product of two numbers of the same sign.", "iAGgoN41T7E-00080-00024380-00024622": "Then, \"x cubed\" equals", "iAGgoN41T7E-00081-00024622-00024832": "\"y\" plus 1 - all to the power of 3 -", "iAGgoN41T7E-00082-00024832-00025071": "minus \"y\" times \"y plus 3\"", "iAGgoN41T7E-00083-00025072-00025472": "is smaller than \"y plus 1\" cubed.", "iAGgoN41T7E-00084-00025472-00025691": "In that case, \"x cubed\"", "iAGgoN41T7E-00085-00025691-00025990": "is bigger than \"y cubed\" and", "iAGgoN41T7E-00086-00025990-00026305": "is smaller than \"y plus 1\" cubed.", "iAGgoN41T7E-00087-00026306-00026804": "Equality given in this exercise has no solution in the set of integers.", "iAGgoN41T7E-00088-00026854-00027612": "We are left with one case, when \"y\" is one of the numbers: \"- 3\" \"- 2\" \"- 1\" and \"0\".", "iAGgoN41T7E-00089-00027670-00027958": "Substituting for the equation each of the given numbers,", "iAGgoN41T7E-00090-00027958-00028281": "we can affirm that if \"y= - 3\"", "iAGgoN41T7E-00091-00028281-00028581": "then \"x cubed\" is equal to \"- 8\".", "iAGgoN41T7E-00092-00028582-00028832": "This means that \"x\" is equal to \"- 2\".", "iAGgoN41T7E-00093-00028832-00029060": "If \"y= - 2\" then", "iAGgoN41T7E-00094-00029060-00029477": "\"x cubed\" is equal to \"1\" and \"x\" is equal to \"1\".", "iAGgoN41T7E-00095-00029506-00029745": "If \"y= - 1\" then", "iAGgoN41T7E-00096-00029745-00030204": "\"x cubed\" is equal to \"2\" and that has no solution in the set of integers.", "iAGgoN41T7E-00097-00030204-00030369": "If \"y= 0\" then", "iAGgoN41T7E-00098-00030370-00030633": "\"x cubed\" is equal to 1", "iAGgoN41T7E-00099-00030633-00030810": "and \"x\" is equal to \"1\".", "iAGgoN41T7E-00100-00030810-00031139": "In the end, we are presented with three (x,y) pairs", "iAGgoN41T7E-00101-00031139-00031268": "that satisfy this equation:", "iAGgoN41T7E-00102-00031268-00031468": "(- 2, - 3),", "iAGgoN41T7E-00103-00031488-00031668": "(1, - 2),", "iAGgoN41T7E-00104-00031668-00031820": "and (1,0).", "iAGgoN41T7E-00105-00031820-00032444": "Right now this is all we have about squares, cubes and potentially higher powers of integers.", "iAGgoN41T7E-00106-00032510-00032616": "In the next video", "iAGgoN41T7E-00107-00032616-00032924": "next article from the SQUARE #20, titled:", "iAGgoN41T7E-00108-00032924-00033227": "\"Let's finish drawing the parallelogram - a bit of geometry\"", "iAGgoN41T7E-00109-00033227-00033532": "I cordially invite you to watch it and, as always,", "iAGgoN41T7E-00110-00033532-00033782": "you can solve all of the exercises on your own by visiting:", "iAGgoN41T7E-00111-00033782-00034155": "www.omj.edu.pl/gazetka-omj", "iAGgoN41T7E-00112-00034156-00034566": "or by choosing \"Gazetka Olimpiady\" (\"Olympiad's Newspaper\") on the main page.", "iAGgoN41T7E-00113-00034566-00035064": "Subtitles/Translation WYTFURNIA.PL [MK] Visit: WYTFURNIA.PL/services"}}, {"audio_id": "iAHluJapkkE", "text": {"iAHluJapkkE-00000-00000000-00000488": ">> GOOD MORNING, EVERYONE. WELL WELCOME TO TODAY HE'S LECTUREMENT AS", "iAHluJapkkE-00001-00000488-00001291": "I SAID LAST WEEK MOST OF THE LECTURES FOCUS ON THE GENOMIC ANALYSIS OF THE MAMMALIAN SYSTEM.", "iAHluJapkkE-00002-00001291-00002165": "LAST WEEK WE TOOK A DEPATURE TALKED HOW TO ANALYZE THE MICROBES THAT LIVE ON AND INSIDE", "iAHluJapkkE-00003-00002165-00002556": "OF US. TODAY WE'RE GOING TO EXPLORE ANOTHER WAY THAT", "iAHluJapkkE-00004-00002556-00002993": "PEOPLE ARE DIFFERENT NAMELY IN RESPONSE TO MEDICINE.", "iAHluJapkkE-00005-00002993-00004273": "OUR SPEAKER THIS MORNING IS HOWARD MCLEOD FROM THE UNIVERSITY OF NORTH CAROLINA.", "iAHluJapkkE-00006-00004273-00005574": "DR. MCLEOD'S EXPERTISE IS INTEGRATING -- HE IS A DISTINGUISHED PROFESSOR AND DIRECTOR", "iAHluJapkkE-00007-00005574-00006948": "OF UNC OF THE FOAM DEPARTMENT. AND NETWORK OF LABS EVALUATING PATHWAYS REGULATING", "iAHluJapkkE-00008-00006948-00007364": "DRUG ACTIVITIES. FOAMS PHARMACOGENOMICS PLEASE WELCOME -- PLEASE", "iAHluJapkkE-00009-00007364-00008413": "JOIN ME IN WELCOMING DR. MCLEOD TO GIVE THIS MORNING'S LECTURE ON PHARMACOGENOMICS.", "iAHluJapkkE-00010-00008413-00008575": "[APPLAUSE] >> THANK YOU VERY MUCH.", "iAHluJapkkE-00011-00008575-00009035": "A PLEASURE TO BE HERE AND TO TALK TO THIS AUDIENCE.", "iAHluJapkkE-00012-00009035-00009664": "THERE IS MANY OF THE ASPECTS OF GENOMICS THAT YOU KNOW MUCH MORE ABOUT THAN I DO.", "iAHluJapkkE-00013-00009664-00010346": "SO I'M GOING TO TRY TO TELL YOU A BIT HOW WE'RE TRYING TO USE THE GENOME FOR GOOD AND", "iAHluJapkkE-00014-00010346-00010946": "HOPEFULLY NOT EVIL ALTHOUGH I'LL HIT ON SOME OF THE EVIL PARTS AS WELL AS WE'RE GOING FORWARD.", "iAHluJapkkE-00015-00010946-00011489": "BUT THE AREA OF PHARMACOGENOMICS IS ONE THAT IS HYPED UP QUOTE A LOT IN TERMS OF TRYING", "iAHluJapkkE-00016-00011489-00011952": "TO USE GENETIC INFORMATION FOR MAKING DECISIONS ABOUT MEDICINE.", "iAHluJapkkE-00017-00011952-00012671": "SO I HOPEFULLY TALK THROUGH SOME OF THE REALITIES OF WHERE WE ARE CURRENTLY INCLUDING SOME OF", "iAHluJapkkE-00018-00012671-00013328": "THE DISCOVERY PIECES THAT NEED TO BE DONE. IT WON'T JUST BE ON LATE CLINICAL APPLICATIONS", "iAHluJapkkE-00019-00013328-00013953": "BUT START OFF ON SOME OF THE DISCOVERY. I LIKE TO START WITH THIS QUOTE HERE.", "iAHluJapkkE-00020-00013953-00014825": "SURGEON WHO CRUISE THE WRONG SIDE OF THE SCALPEL CUTS THEIR OWN CONTINUINGERS IF NOT THE PATIENTS.", "iAHluJapkkE-00021-00014825-00015282": "THIS QUOTE SUPPOSEDLY FROM 1849. I DON'T READ THIS PARTICULAR JOURNAL.", "iAHluJapkkE-00022-00015282-00015821": "BUT IT'S VERY TRUE TODAY THAT OF THE FDA APPROVED DRUGS THAT WE HAVE AVAILABLE IN THIS COUNTRY,", "iAHluJapkkE-00023-00015821-00016305": "THERE ARE NONE OF THEM THAT WE TRULY KNOW THE MECHANISM OF ACTION.", "iAHluJapkkE-00024-00016305-00016723": "NOW, IF YOU'RE A STUDENT OR FELLOW OR SOMEBODY LIKE THAT YOU HAVE TO TAKE AN EXAM, THERE'S", "iAHluJapkkE-00025-00016723-00017236": "OF COURSE A RIGHT ANSWER OF HOW A DRUG WORKS. YOU HAVE TO PRETEND THAT THAT'S THE TRUTH.", "iAHluJapkkE-00026-00017236-00017580": "BUT THE REALITY IS WE DON'T KNOW HOW DRUGS WORK.", "iAHluJapkkE-00027-00017580-00017915": "WE KNOW THAT CERTAIN TARGETS AND OFTEN LABEL THEM BY THAT.", "iAHluJapkkE-00028-00017915-00019098": "BUT INHIBITORS.", "iAHluJapkkE-00029-00019098-00019531": "BUT NOT ENOUGH ABOUT MEDICINE TO REALLY DIAL IN FOR EACH INDIVIDUAL PERSON.", "iAHluJapkkE-00030-00019531-00020070": "SO IF YOU TAKE A GROUP OF PEOPLE WITH YOUR FAVORITE DISEASE, TREAT THEM WITH YOUR FAVORITE", "iAHluJapkkE-00031-00020070-00020696": "THERAPY, IN RETROSPECT PEOPLE WILL STAND OUT. THEY WILL STAND OUT FOR TWO IMPORTANT REASONS.", "iAHluJapkkE-00032-00020696-00021154": "LACK OF THERAPEUTIC BENEFIT AND UNACCEPTABLE LEVELS OF TOXICITY.", "iAHluJapkkE-00033-00021154-00022056": "SO THE GOAL IS HOW DO WE GO AND TAKE THIS TECHNOLOGY ABOUT THE PATIENT AND TRY TO MAKE", "iAHluJapkkE-00034-00022056-00022333": "IT SO THAT THESE FOLKS HERE GET AN ALTERNATE THERAPY.", "iAHluJapkkE-00035-00022333-00022770": "RATHER THAN THE USUAL THERAPY THAT WE MIGHT GIVE.", "iAHluJapkkE-00036-00022770-00023215": "NOW, THE CLINICAL PROBLEM THAT WE HAVE IN THE THERAPEUTIC SIDE IS REALLY A WONDERFUL", "iAHluJapkkE-00037-00023215-00023729": "PROBLEM. THERE IS QUITE A LOT OF YOUNG LOOKING PEOPLE", "iAHluJapkkE-00038-00023729-00024218": "IN THE AUDIENCE, NOT EVERYONE, OF COURSE, BUT QUITE A LOT OF YOUNG LOOKING IN THE AUDIENCE", "iAHluJapkkE-00039-00024218-00024695": "YOU MAY NOT REALIZE THAT IT WASN'T THAT LONG AGO THAT THERE WEREN'T A LOT OF CHOICES FOR", "iAHluJapkkE-00040-00024695-00025014": "MOST COMMON DISEASES. IF YOU TAKE AREA OF CANCER, WHERE I SPEND", "iAHluJapkkE-00041-00025014-00025543": "A LOT OF MY ENERGY IN THE TREATMENT OF COLON CANCER UP UNTIL ABOUT TEN YEARS AGO THE BIG", "iAHluJapkkE-00042-00025543-00026708": "QUESTION WAS, DO I GIVE -- BASICALLY FROM 1958 UNTIL 1996 THERE WAS ONLY ONE DRUG AVAILABLE", "iAHluJapkkE-00043-00026708-00027387": "FOR THAT COMMON DISEASE. NOW THERE ARE MORE COMING JUST FOR THE TREATMENT", "iAHluJapkkE-00044-00027387-00027869": "OF THAT ONE DISEASE. REAL CHOICES NEED TO BE MADE.", "iAHluJapkkE-00045-00027869-00028481": "THE UNFORTUNATE TRUTH AROUND THE MODERN THERAPIES IS THAT WITH THE EXCEPTION OF BONE AND MINERAL", "iAHluJapkkE-00046-00028481-00029071": "DISEASE AND BACTERIAL INFECTION, MOST THERAPIES WILL ONLY WORK IN ABOUT HALF OF THE PATIENTS", "iAHluJapkkE-00047-00029071-00029574": "IN WHICH THEY'RE TRIED. SO YOU GIVE A PATIENT A DRUG, HALF OF GROUP", "iAHluJapkkE-00048-00029574-00030093": "OF PATIENTS WILL NEED TO SWITCH TO A SECOND DRUG EITHER SEQUENTIALLY OR ADDITIVELY AND", "iAHluJapkkE-00049-00030093-00030602": "SOME WILL NEED A THIRD OR FOURTH DRUG. YOU GET TO THE POINT WHERE PEOPLE SWITCH OVER", "iAHluJapkkE-00050-00030602-00031147": "TO HOMEOPATHY ALL SORTS OF OTHER THINGS BECAUSE THEY LOSE FAITH IN ALLOPATHIC APPROACH BECAUSE", "iAHluJapkkE-00051-00031147-00031844": "WE DON'T SEEM TO KNOW WHAT WE'RE DOING. WHY NOT GO TO QUACKERY BECAUSE IT'S J AS GOOD", "iAHluJapkkE-00052-00031844-00032358": "AS WHAT WE'RE UP TO. THERE'S ALSO UNPREDICTABLE TOXICITY.", "iAHluJapkkE-00053-00032358-00033037": "THERE'S CAN WE TAKE THE IDIDIO OUT OF IDIOPATHIC. TRYING TO MAKE IT TO PREDICT.", "iAHluJapkkE-00054-00033037-00033686": "THEY ARE A BIG DEAL. IT HAPPENED TO THE PATIENT NOT THE PRESCRIBER,", "iAHluJapkkE-00055-00033686-00034186": "SO THEY'RE NOT GIVEN THE FIRST PRIORITY. BUT THEY ARE VERY BIG DEAL IN TERMS OF WHETHER", "iAHluJapkkE-00056-00034186-00034697": "PATIENTS TAKE THEIR MEDICINE AND IN TERMS OF WHETHER THEY ARE ABLE TO SUSTAIN THEIR", "iAHluJapkkE-00057-00034697-00035099": "THERAPY. MUCH OF THE MODERN THERAPY FOR COLON CANCER", "iAHluJapkkE-00058-00035099-00035461": "IS INCREDIBLY ACTIVE BUT ALSO HARMS THE PERIPHERAL NERVES.", "iAHluJapkkE-00059-00035461-00035952": "SO WE HAVE MANY SITUATIONS WHERE A PATIENT'S TUMOR IS RESPONDING NICELY BUT WE HAVE TO", "iAHluJapkkE-00060-00035952-00036602": "STOP THE THERAPY BECAUSE WE'RE FRYING THEIR NERVES, THEY CAN'T FEEL THEIR FINGERS THAT'S", "iAHluJapkkE-00061-00036602-00037231": "SO THAT SITUATION WHERE WE CANNOT OPTIMIZE CONTROL OF THE DISEASE BECAUSE OF TOXICITY", "iAHluJapkkE-00062-00037231-00037690": "IS A BIG DEAL. IN THE AREA OF CANCER, THEY GRADE TOXICITY", "iAHluJapkkE-00063-00037690-00038213": "FROM ZERO MEANING NONE UP TO FIVE MEANING YOU ACTUALLY KILLED THE PATIENT WITH THE TOXICITY.", "iAHluJapkkE-00064-00038213-00038724": "SO WHEN I GO TO THE DATA CENTER TO LOOK AT TRIALS THAT I'M RUNNING, JUST GIVE ME THE", "iAHluJapkkE-00065-00038724-00039269": "SEVERE TOXICITY, GRADE THREE OR FOUR STUFF. IF I HAD GREAT ONE DIARRHEA RIGHT NOW I'D", "iAHluJapkkE-00066-00039269-00039887": "BE TALKING TO YOU FROM A LITTLE ROOM OUTSIDE THAT SAYS NBN ON THE DOOR.", "iAHluJapkkE-00067-00039887-00040559": "EVEN SMALL AMOUNT CAN BE DEBILITATING TO A PATIENT YET IT'S NOT EVEN ON MY RADAR BECAUSE", "iAHluJapkkE-00068-00040559-00041185": "IT'S JUST SILLY LITTLE PROBLEM. WHY BOTHER.", "iAHluJapkkE-00069-00041185-00041693": "SO TRYING TO MAKE SURE WE TRY TO OPTIMIZE THE CONTROLLED DISEASE AND ACCEPT ONLY LEVEL", "iAHluJapkkE-00070-00041693-00042318": "OF TOXICITY IS IMPORTANT ASPECT. THEN THERE'S THE ELEMENT THAT THOSE OF US", "iAHluJapkkE-00071-00042318-00042803": "JUST DON'T WANT TO FACE. THAT IS THE FACT THAT MODERN THERAPIES FOR", "iAHluJapkkE-00072-00042803-00043284": "MOST DISEASES CERTAINLY IN CRUDING CANCER COST REAL MONEY.", "iAHluJapkkE-00073-00043284-00044016": "AND IN A RICH COUNTRY LIKE OURS WE CAN'T AFFORD THE MODERN THERAPY FOR ALL PEOPLE.", "iAHluJapkkE-00074-00044016-00044600": "IT'S TIMELY THAT WE'RE TALKING ABOUT THIS TODAY, BUT EVERYTHING SPENT FAIR AMOUNT OF", "iAHluJapkkE-00075-00044600-00045090": "TIME IN EUROPE, I WAS THERE IN SCOTLAND FOR EIGHT YEARS, I HAVE SEEN WHAT IT MEANS TO", "iAHluJapkkE-00076-00045090-00045600": "HAVE LIMITED THERAPY BUDGET. WHEN YOU GET DONE WITH THAT BUDGET THERE IS", "iAHluJapkkE-00077-00045600-00046080": "NO ADDITIONAL BUDGET FOR THERAPY. IF YOU EVER WONDER WHY CLINICAL TRIALS ARE", "iAHluJapkkE-00078-00046080-00046574": "SO SUCCESSFUL IN OTHER PARTS OF THE WORLD, PART IS THERE AREN'T A LOT OF OTHER OPTIONS,", "iAHluJapkkE-00079-00046574-00046980": "IF YOU RUN OUT OF YOUR DRUG BUDGETS CLINICAL TRIALS ARE ONLY THE ONLY OPTION FOR THE TREATMENT.", "iAHluJapkkE-00080-00046980-00047977": "CAN WE OFFER PATIENT THERAPY THAT WILL OPTIMIZE THE CONTROL OF THEIR DISEASE, BUT IN THE CONTEXT", "iAHluJapkkE-00081-00047977-00048481": "OF OUR HEALTH SYSTEM AND LIMITED EXPENSE. I DON'T MEAN WE SHOULD ALL BECOME HEALTH SERVICES", "iAHluJapkkE-00082-00048481-00049052": "RESEARCHERS, PLEASE DO NOT DO THAT. RATHER WE NEED TO STOP THINKING ABOUT THINGS", "iAHluJapkkE-00083-00049052-00049758": "IN SUCH A NARROW VIEW AND REALIZE THAT IT'S THE COMPILATION OF THESE AREAS THAT DRIVE", "iAHluJapkkE-00084-00049758-00050268": "HEALTH CARE F. WE ONLY DO RESEARCH TRYING TO DO ONE OF THESE THREE THINGS, IF NO OF", "iAHluJapkkE-00085-00050268-00050849": "THE REST WE'LL NEVER SUCCEED TO THE FULL THAN WE WANT TO.", "iAHluJapkkE-00086-00050849-00051571": "I SHOW THIS SLIDE, LOOK LIKE IT'S STOLEN FROM REVIEW, LOOKS LIKE THE FONT DIDN'T COME THROUGH", "iAHluJapkkE-00087-00051571-00052077": "TO GIVE HIM FULL CREDIT. WHAT THIS IS SHOWING IS THAT GENETICS IS AT", "iAHluJapkkE-00088-00052077-00052459": "THE HUB OF THE WHEEL. THAT'S GREAT.", "iAHluJapkkE-00089-00052459-00052837": "YOU WOULDN'T HAVE COME TO THIS TALK IF YOU DIDN'T THINK GENETIC AND DENOME I CAN MEANT", "iAHluJapkkE-00090-00052837-00053441": "SOMETHING UNLESS YOU'RE REALLY DESPERATE FOR CONTINUING EDUCATION CREDITS.", "iAHluJapkkE-00091-00053441-00053971": "THE GENOMICS IS CERTAINLY VARIABLE THAT IS IMPORTANT, LOOKING AROUND THE ROOM HERE A", "iAHluJapkkE-00092-00053971-00054447": "LOT OF VARIABILITY IN OUTWARD APPEARANCE. MUCH REGULATED BY GENETICS, SKIN PIGMENT,", "iAHluJapkkE-00093-00054447-00055020": "HAIR COLOR, SOME ASPECTS OF BODY, FEW THAT HAVE MET MY CHILDREN KNOW THEY LOOK MORE LIKE", "iAHluJapkkE-00094-00055020-00055350": "ME THAN YOU, GOOD THING FOR YOU, BAD THINGS FOR THEM.", "iAHluJapkkE-00095-00055350-00056591": "GENETIC CAN REGULATE OUTWARDS, ABSORPTION OF A DRUG, METABOLISM, AMOUNT OF TARGETS FOR", "iAHluJapkkE-00096-00056591-00057219": "A DRUG CAN BE REGULATED AT THE GENETIC LEVEL. BUT OUTSIDE OF THE CIRCLE ARE NUMBER OF FACTORS", "iAHluJapkkE-00097-00057219-00057645": "THAT CAN BE VERY IMPORTANT CLINICALLY HAVE NOTHING TO DO WITH GENETICS IN MANY CASES.", "iAHluJapkkE-00098-00057645-00058023": "A DRUG-DRUG INTER-A CAN BE VERY IMPORTANT CLINICALLY.", "iAHluJapkkE-00099-00058023-00058478": "OFTEN NO GENETIC BASIS WHATSOEVER. POOR KIDNEY AND LIVER FUNCTION CAN BE VERY", "iAHluJapkkE-00100-00058478-00058900": "IMPORTANT CLINICALLY. OFTEN HAS NO GENETIC BASIS IN TERMS OF THAT.", "iAHluJapkkE-00101-00058900-00059365": "IF YOUR PATIENTS ARE FROM THE COAST OF NORTH CAROLINA ARE SURFERS, MARIJUANA INTAKE CAN", "iAHluJapkkE-00102-00059365-00059950": "INFLUENCE METABOLISM, MAY HAVE NO GENETIC INFLUENCE BUT CAN BE IMPORTANT IN TERMS OF", "iAHluJapkkE-00103-00059950-00060462": "THE THERAPEUTIC SITE. SO JUST REMINDER THAT THE GENOME IS A TOOL", "iAHluJapkkE-00104-00060462-00060883": "FOR UNDERSTANDING INTER--PATIENT VARIABILITY BUT IT IS NOT THE TOOL.", "iAHluJapkkE-00105-00060883-00061639": "CERTAINLY THE GENOME PROJECT DURING INITIAL YEARS CAME OFF SAYING, GET OUT OF THE WAY", "iAHluJapkkE-00106-00061639-00062061": "SO WE CAN CURE YOUR PATIENT. AS OPPOSED TO, HERE IS A USEFUL TOOL THAT", "iAHluJapkkE-00107-00062061-00062596": "MIGHT BENEFIT YOU IN UNDERSTANDING YOUR PATIENT IN MUCH MORE -- MUCH BETTER WAY.", "iAHluJapkkE-00108-00062596-00063115": "SO WE'RE JUST NOW GETTING AROUND TO THE POINT WHERE PEOPLE ARE STRONGLY CONSIDER GENOME", "iAHluJapkkE-00109-00063115-00063712": "AS TOOL BECAUSE OF SOME OF THESE INITIAL ISSUES. SO I'LL TRY TO HIGHLIGHT WHERE THE GENOME", "iAHluJapkkE-00110-00063712-00064344": "IS USEFUL BUT ALSO FACT THAT WE NEED TO ASK THE QUESTION, IS THE GENOME USEFUL.", "iAHluJapkkE-00111-00064344-00065185": "WE'LL COME BACK TO THAT POINT IN A COUPLE OF SLIDES.", "iAHluJapkkE-00112-00065185-00065831": "THIS SLIDE TO SHOW YOU THAT WE'RE NOT AT THE BEGINNING OF PHARMACOGENOMICS.", "iAHluJapkkE-00113-00065831-00066646": "THE FOOD AND DRUG ADMINISTRATION HAS CHANGED THE PRESCRIBING RECOMMENDATION IN THE DOSAGE", "iAHluJapkkE-00114-00066646-00067044": "AND ADMINISTRATION SECTION OF THE PACKAGE INSERT.", "iAHluJapkkE-00115-00067044-00067696": "THIS PACKAGE INSERT IS THE ASPECT OF -- THIS SECTION IS THE ASPECT THAT ALL CLINICIANS", "iAHluJapkkE-00116-00067696-00068116": "ARE SUPPOSED TO READ, WE KNOW THAT DOESN'T HAPPEN.", "iAHluJapkkE-00117-00068116-00068498": "ALL INSURANCE COMPANIES DO READ IN TERMS OF THEIR DECISIONS.", "iAHluJapkkE-00118-00068498-00069146": "OF COURSE THEY'RE HEAVILY RED BY LITIGATORS. NOW SEEING EXAMPLES NOT JUST IN THE CLINICAL", "iAHluJapkkE-00119-00069146-00069582": "PHARMACOLOGY SECTION OR SOMEWHERE BURIED DEEP IN THE PACKAGE INSERTS BUT UP IN THE DRUG", "iAHluJapkkE-00120-00069582-00069905": "ADMINISTRATION SECTION. ONE THAT PEOPLE ACTUALLY HAVE TO PAY ATTENTION", "iAHluJapkkE-00121-00069905-00070464": "TO FOR A NUMBER OF DIFFERENT DRUGS. SOME OF THESE ARE SOMATIC MUTATIONS, CHROMOSOMES", "iAHluJapkkE-00122-00070464-00071096": "OLDER THAN MOST OF YOU. IN TERMS OF ITS FINDING, HER 2 IS AN OLD STORY.", "iAHluJapkkE-00123-00071096-00071719": "OTHER EXAMPLES IN TERMS OF SOME OF THE HLAS FOR SEVERE HYPERSENSITIVITY REACTION THEN", "iAHluJapkkE-00124-00071719-00072570": "MOST RECENTLY A WEEK AGO THURSDAY THE FDA PUT BLACK BOX FOR GENETIC INFORMATION IN TERMS", "iAHluJapkkE-00125-00072570-00073208": "OF LACK OF EFFICACY FOR -- WHICH THE YOU'RE NOT FAMILIAR WITH THAT DRUG, ALSO KNOWN AS", "iAHluJapkkE-00126-00073208-00073544": "PLAVIX. IF YOU WATCHED TV YOU'VE SEEN A PLAVIX AD.", "iAHluJapkkE-00127-00073544-00074043": "ALMOST AS COMMON AS VIAGRA IN TERMS OF ITS ADS.", "iAHluJapkkE-00128-00074043-00074503": "NOW DRUGS THAT YOU HAVE HEARD ABOUT THAT HAVE GENETIC INFORMATION.", "iAHluJapkkE-00129-00074503-00075246": "IN THAT CASE LARGE PERCENTAGE OF THE POPULATION, CANNOT ACTIVATE THIS DRUG THERE FOR WILL NOT", "iAHluJapkkE-00130-00075246-00075762": "GET CLINICAL BENEFIT FROM THIS THERAPY AND YOU DON'T KNOW ABOUT IT UNTIL IT'S TOO LATE.", "iAHluJapkkE-00131-00075762-00076696": "WE'RE ALSO TALKING ABOUT NUMBER OF DRUGS THAT ARE COMMONLY USED ACROSS DISEASE AREAS.", "iAHluJapkkE-00132-00076696-00077507": "THE ANTAGONIST ARE USED FOR NAUSEA AND VOMITING AND CANCER ALSO USE FOR ANESTHESIA PRIOR TO", "iAHluJapkkE-00133-00077507-00077926": "GENERAL ANESTHESIA TO PREVENT THE NAUSEA AND VOMITING IN THAT CASE.", "iAHluJapkkE-00134-00077926-00078898": "THERE'S A LOT OF SURGERY GOING ON. WE'RE TALKING ABOUT EXAMPLES WHERE THOUSANDS", "iAHluJapkkE-00135-00078898-00079600": "OF PATIENTS PER MEDICAL CENTER ARE NOW ELIGIBLE FOR GENETIC GUIDED THERAPY FOR COMMON DISEASES.", "iAHluJapkkE-00136-00079600-00080247": "IT'S NO LONGER A BOUTIQUE INCIDENT SOME RARE DISEASE WHERE ONE PERSON IN THE U.S. MIGHT", "iAHluJapkkE-00137-00080247-00080701": "CARE ABOUT IT. BUT SOMETHING WHICH IS VERY COMMON ISSUE.", "iAHluJapkkE-00138-00080701-00081316": "I'M GOING TO FOCUS IN ON COUPLE OF THESE EXAMPLES AS WE GO ALONG THROUGH THIS.", "iAHluJapkkE-00139-00081316-00081814": "BUT WE'RE NOT TALKING ABOUT A NEWS STORY, SOMETHING THAT IS NOW REALLY ROLLING ALONG", "iAHluJapkkE-00140-00081814-00082390": "AT A FAIRLY RABID PACE. I'M GOING TO HIT ON THREE FUNDAMENTAL ISSUES", "iAHluJapkkE-00141-00082390-00082966": "AS WE GO THROUGH THESE SLIDES. FIRST OF ALL TRYING TO FIND THE RIGHT BIOMARKERS.", "iAHluJapkkE-00142-00082966-00083534": "LOOKING AT MORE OF THE DISCOVERY SIDE OF WHAT'S BEING DONE WHAT CAN BE DONE TO BE SMARTER", "iAHluJapkkE-00143-00083534-00083872": "ABOUT THAT. SECONDLY A LITTLE BIT ABOUT VALIDATION IN", "iAHluJapkkE-00144-00083872-00084389": "TERMS OF HAVING PROPER DATA SETS TO VALIDATE AS OPPOSED TO SOME OF THE APPROACHES THAT", "iAHluJapkkE-00145-00084389-00084879": "HAVE BEEN TAKEN IN THE PAST. THEN LASTLY ACTUALLY APPLYING THIS INFORMATION", "iAHluJapkkE-00146-00084879-00085224": "TO REAL PEOPLE FOR REAL TREATMENT OF REAL DISEASES.", "iAHluJapkkE-00147-00085224-00085880": "AND WHERE THINGS ARE IN THAT CASE. THE REASON WHY DISCOVERY IS STILL NEEDED COMES", "iAHluJapkkE-00148-00085880-00086234": "BACK TO THAT INITIAL SLIDE ABOUT UNDERSTANDING DRUGS.", "iAHluJapkkE-00149-00086234-00087959": "WE THINK WE'RE QUITE SMART. WE CAN GO TAKE DRUG LIKE IT CAN BE INACTIVATED", "iAHluJapkkE-00150-00087959-00088579": "WHICH ITSELF CAN CAN PUMPED OUT, HIT CELLULAR TARGET.", "iAHluJapkkE-00151-00088579-00088978": "WE ARE SMART. IF I HAD GOOD GRAPHIC ARTIST I'D BE EVEN SMARTER.", "iAHluJapkkE-00152-00088978-00089469": "WE LOOK AT THIS SORT OF THING WE THINK WE'RE GENIUSES.", "iAHluJapkkE-00153-00089469-00090068": "HERE IS THE REAL PATHWAY. ESPECIALLY IN THE F.D.A. ASPECT WE PRACTICE", "iAHluJapkkE-00154-00090068-00090469": "-- THE PHARMACODYNAMIC ASPECT. WE KNOW WHAT WE KNOW BUT WE DON'T KNOW WHAT", "iAHluJapkkE-00155-00090469-00090856": "WE DON'T KNOW. WE KNOW THAT THESE GENES HAVE POTENTIAL OF", "iAHluJapkkE-00156-00090856-00091413": "BEING IMPORTANT BECAUSE SOMEONE KNOCKED THEM OUT OR OVER EXPRESSED OR DONE SOMETHING TO", "iAHluJapkkE-00157-00091413-00092148": "THAT IN A LABORATORY, IN A MOUSE, IN MAN. WE HAVE NOT STEPPED BACK ASKED BIOLOGY TO", "iAHluJapkkE-00158-00092148-00092756": "TELL US WHICH GENES SHOULD WE CARE ABOUT. OFTEN WE HAVE THESE PATHWAYS THEY LOOK REALLY", "iAHluJapkkE-00159-00092756-00093001": "SLICK. IF YOU GO TO THE PHARMACOGENETIC KNOWLEDGE", "iAHluJapkkE-00160-00093001-00094118": "BASE, YOU CAN SEE THESE BEAUTIFUL GRAPHIC ARTIST DEPICTED -- BEAUTIFUL GRAPHIC ARTIST", "iAHluJapkkE-00161-00094118-00094555": "DEPICTIONS OF DRUG PATHWAYS THAT REALLY LOOK LIKE WE UNDERSTAND SOMETHING.", "iAHluJapkkE-00162-00094555-00095188": "BUT WE HAVE LONG WAY TO GO. SO THERE IS LOT OF -- EVEN IN 2010 THERE'S", "iAHluJapkkE-00163-00095188-00095883": "LOT OF NEED FOR STEPPING BACK ASKING QUESTIONS ABOUT WHETHER WE KNOW THE RIGHT GENE.", "iAHluJapkkE-00164-00095883-00096513": "SO WHETHER IT'S IN MOUSE, IN FAMILIES, LARGE POPULATIONS STUDIES WE NEED TO REALLY ASK", "iAHluJapkkE-00165-00096513-00097148": "THAT QUESTION. ONE EXAMPLE THAT WE'VE DONE TO TRY TO USE", "iAHluJapkkE-00166-00097148-00097924": "FAMILY, USE FAMILY STRUCTURE ALL THE DECADES OF KNOWLEDGE ABOUT HOW TO CONDUCT A FAMILY", "iAHluJapkkE-00167-00097924-00098399": "GENETIC STUDY IN THE CONTEXT OF CHEMOTHERAPY DRUGS.", "iAHluJapkkE-00168-00098399-00098713": "WE CAN'T DO TRUE FAMILY STUDIES WITH CHEMOTHERAPY DRUGS.", "iAHluJapkkE-00169-00098713-00099438": "YOU CAN'T BRING FAMILY, EXTENDED FAMILY IN TO THE CLINICAL CENTER HERE GIVE THEM ALL", "iAHluJapkkE-00170-00099438-00099937": "CYTOTOXIC CHEMOTHERAPY SEE WHO GETS SEVERE NEUTROPENIA.", "iAHluJapkkE-00171-00099937-00100304": "SLIGHTLY UNETHICAL. YOU DON'T WANT TO BE SAYING, SORRY ABOUT GRANDMA", "iAHluJapkkE-00172-00100304-00100767": "THAT'S NOT SOMETHING YOU WANT TO BE SAYING WITH YOUR STUDY.", "iAHluJapkkE-00173-00100767-00101549": "YOU CAN'T DO TWIN STUDIES FOR THE SAME REASON. WHAT WE'VE DONE TAKEN THIS IN TO THE IN VITRO", "iAHluJapkkE-00174-00101549-00101846": "SETTING. ONE OF THE FIRST QUESTIONS WE WANTED TO ASK", "iAHluJapkkE-00175-00101846-00102807": "IS, IS CYTOTOXIC CHEMOTHERAPY RESPONSE A GENETIC PROBLEM.", "iAHluJapkkE-00176-00102807-00103493": "IT'S SHOCKING TO ME AFTER WE FINALLY CAME AROUND TO THINKING THIS WAY, IT WAS SHOCKING", "iAHluJapkkE-00177-00103493-00104031": "TO LOOK AT THE WAY WE'VE BEEN APPROACHING PHARMACOGENOMICS OVER THE LAST DECADE OR SO.", "iAHluJapkkE-00178-00104031-00104784": "WE'VE ASSUMED THAT GENETICS WAS RELEVANT. THAT'S FINE.", "iAHluJapkkE-00179-00104784-00105205": "THOSE OF YOU THAT ARE IN GENETICS YOU WANT IT TO BE RELEVANT, IT'S YOUR LIFE.", "iAHluJapkkE-00180-00105205-00105807": "THERE'S OLD SAYING, IF YOU HAVE A HAMMER ALL THE WORLD LOOK LIKE A NAIL.", "iAHluJapkkE-00181-00105807-00106350": "WELL, IF YOU HAVE A SEQUENCER OR NEXT GENERAL MACHINE OR WHATEVER IT MIGHT BE EVERY PROBLEM", "iAHluJapkkE-00182-00106350-00106828": "LOOKS LIKE A GENETIC PROBLEM. TOO OFTEN WITH WE'RE DOING SPENDING LARGE", "iAHluJapkkE-00183-00106828-00107451": "AMOUNT OF MONEY TO GENOTYPE OR SEQUENCE OR SOME OTHER WAY LOOK AT THE GENOME WHEN WE", "iAHluJapkkE-00184-00107451-00107698": "DON'T HAVE CLUE IF GENETICS IS INVOLVED AT ALL.", "iAHluJapkkE-00185-00107698-00108447": "PRETTY IS PRETTY STUPID. SOME OF YOU ARE INVOLVED IN FUNDING DECISIONS", "iAHluJapkkE-00186-00108447-00109116": "I'D LIKE TO YOU PLEASE FORGET. THAT BUT WE REALLY NEED TO ASK THE QUESTION,", "iAHluJapkkE-00187-00109116-00109746": "SHOULD WE EVEN BE TRYING TO LOOK AT GENOMICS BECAUSE TOO OFTEN WE'RE DOING IT BECAUSE WE", "iAHluJapkkE-00188-00109746-00110302": "CAN, NOT BECAUSE WE SHOULD. SO WE ASK QUESTION USING SOME OF THESE FAMILIES.", "iAHluJapkkE-00189-00110302-00110894": "SO MOST OF YOU ARE FAMILIAR WITH THE -- CELL LINE IMPORTANT PART OF THE HUMAN GENOME PROJECT", "iAHluJapkkE-00190-00110894-00111483": "AND HAPMAP PROJECT AND MANY OTHERS YOU CAN GET THESE CELL LINES FROM THE INSTITUTE WHERE", "iAHluJapkkE-00191-00111483-00111914": "THERE'S EITHER LARGE TWO GENERATION OR MORE COMMONLY THREE GENERATION FAMILIES.", "iAHluJapkkE-00192-00111914-00112808": "YOU CAN TAKE THESE CELL LINES, GROW THEM AS A CULTURE AND DO CYTOTOXICITY TESTS OR OTHER", "iAHluJapkkE-00193-00112808-00113558": "TYPES OF TESTING DEPENDING ON YOUR ASSAY. SO THIS IS THE EXAMPLE OF -- WE USE MAINLY", "iAHluJapkkE-00194-00113558-00114194": "FOUR PLATES NOW BUT IT'S PRETTIER. WHERE THERE'S TWO DIFFERENT DRUGS, ASSAYED", "iAHluJapkkE-00195-00114194-00114904": "IN QUADRUPLICATE. THEN INCREASING AMOUNT OF CONCENTRATION SO", "iAHluJapkkE-00196-00114904-00115472": "THAT YOU SEE DIFFERENT LEVELS BASED ON THE DYE INDICATOR.", "iAHluJapkkE-00197-00115472-00116378": "WHAT YOU CAN DO, USING MULTIPLE REPLICATES YOU CAN GET QUILL CURVES.", "iAHluJapkkE-00198-00116378-00117145": "IN THIS CASE, THERE ARE -- EVE OF THESE LINES IS SEPARATE REPLICATE FOR A SPECIFIC CELL", "iAHluJapkkE-00199-00117145-00117617": "LINE FROM ONE OF THESE FAMILIES. WITH INCREASING CONCENTRATION OF THE ANTI-CANCER", "iAHluJapkkE-00200-00117617-00118352": "DRUGS YOU CAN SEE RATHER STEEP KILLING THAT'S GOING ON HERE AND EACH ONE OF THE REPLICATES", "iAHluJapkkE-00201-00118352-00119145": "ITSELF HAS 12 REPEATS WITHIN IT. IT'S 12 REPLICATES TIMES THREE FOR EACH OF", "iAHluJapkkE-00202-00119145-00119458": "THESE POINTS. THEN OTHER CELL LINES SAME NUMBER OF REPLICATES", "iAHluJapkkE-00203-00119458-00120585": "HAVE MUCH MORE SHALLOW KILL CURVE.", "iAHluJapkkE-00204-00120585-00121217": "FOR THIS PARTICULAR CELL LINE. YOU CAN LOOK AT THE KILLING OF THESE CELLS", "iAHluJapkkE-00205-00121217-00121563": "AND ASK THE QUESTION, IS THIS A HERITABLE TRAIT.", "iAHluJapkkE-00206-00121563-00122442": "HOW HERITABLE IS CYTOTOXICITY. SO WE HAVE ONE PROJECT, WE CALL IT THE -- WHERE", "iAHluJapkkE-00207-00122442-00123085": "WE'VE TAKEN PANEL OF THESE CELL LINES FROM NUMBER OF FAMILIES AND TAKEN ALL OF THE FDA", "iAHluJapkkE-00208-00123085-00123712": "APPROVED ANTI-CANCER DRUGS INCLUDING SOME OF THE KINASE INHIBITORS AND DEMETHYLATION", "iAHluJapkkE-00209-00123712-00124226": "DRUGS, ASKED THE QUESTION ABOUT HERITABILITY. WE DID NOT USE SOME OF THE DRUGS THAT NEEDED", "iAHluJapkkE-00210-00124226-00124539": "ACTIVATION. THERE ARE MANY DRUGS THAT ARE PRO DRUGS.", "iAHluJapkkE-00211-00124539-00125061": "YOU SWALLOW THEM, THEY HAVE TO BE ACTIVATED IN THE LIVER BEFORE THEY CAN WORK IN THE BODY.", "iAHluJapkkE-00212-00125061-00125430": "THAT'S DIFFICULT TO DO IN CELL CULTURES WE DIDN'T ATTEMPT THAT.", "iAHluJapkkE-00213-00125430-00125750": "BUT BY TAKING THESE, WE CAN GENERATE THIS KIND OF DATA.", "iAHluJapkkE-00214-00125750-00126235": "LET ME WALK YOU THROUGH IT BRIEFLY. WHAT THIS IS SHOWING IS SERIES OF ANTI-CANCER", "iAHluJapkkE-00215-00126235-00126649": "DRUGS, MOST FAIRLY COMMONLY PRESCRIBED ANTI-CANCER DRUGS.", "iAHluJapkkE-00216-00126649-00127107": "EITHER CORRECTED FOR GROWTH RATE OR UNCORRECTED FOR GROWTH RATE.", "iAHluJapkkE-00217-00127107-00127779": "ON THIS AXIS IS HERITABILITY OF THE MAXIMUM HERITABILITY ACROSS SEVERAL CONCENTRATIONS", "iAHluJapkkE-00218-00127779-00128152": "FOR EACH DRUG. OVER ON THE LEFT SIDE HERE ARE THE CONTROLS.", "iAHluJapkkE-00219-00128152-00128886": "1% DMSO WATER OR SERUM DEPENDING AS VARIOUS CONTROLS FOR THIS EXPERIMENT.", "iAHluJapkkE-00220-00128886-00129848": "SO WHAT YOU CAN SEE IS THERE'S A DEGREE OF HERITABILITY SEEN ACROSS THE DIFFERENT ANTI-CANCER", "iAHluJapkkE-00221-00129848-00130413": "DRUGS. SOME OF THEM HAVE VERY HIGH HERITABILITY.", "iAHluJapkkE-00222-00130413-00131040": "THEN SOME OF THEM ARE REALLY NO DIFFERENT FROM CONTROLS IN TERMS OF HERITABILITY.", "iAHluJapkkE-00223-00131040-00131520": "NOW THIS IS CELL LINES, LYMPHOBLASTOID CELL LINES.", "iAHluJapkkE-00224-00131520-00132851": "NUMBER OF ASSOCIATIONS, ONE CAN ASK THE QUESTION WHICH DRUGS ARE MORE LIKELY TO HAVE A HIGH", "iAHluJapkkE-00225-00132851-00133421": "LEVEL OF GENETIC INFLUENCE GOING ON. HERITABILITY IS ONLY ONE MEASURE OF TRYING", "iAHluJapkkE-00226-00133421-00133865": "TO LOOK AT WHETHER GENETICS IS RELEVANT. WE'RE WELL AWARE OF THAT.", "iAHluJapkkE-00227-00133865-00134462": "BUT WHAT WE ARE SEEING IS THAT WE HAVE SOME DRUGS WITH VERY HIGH LEVEL OF HERITABILITY", "iAHluJapkkE-00228-00134462-00135099": "AND ARE MUCH MORE LIKELY TO BE THE SOURCE OF GENOMIC DISCOVERY.", "iAHluJapkkE-00229-00135099-00135602": "OTHER DRUGS AT LOW END WE DON'T KNOW EXACTLY WHY THEY'RE LOW, IT'S NOT A LACK OF VARIABILITY", "iAHluJapkkE-00230-00135602-00136266": "IN CYTOTOXICITY JUST A LACK OF HERITABILITY. WE THINK THAT -- IT IS NOT EBB TRANSFORMATION,", "iAHluJapkkE-00231-00136266-00136721": "WE LOOKED IN TO THAT PART OF IT. BUT WE'RE STILL TRYING TO FIGURE OUT, DOES", "iAHluJapkkE-00232-00136721-00137366": "THIS MEAN THESE DRUGS SHOULD NEVER HAVE GENETIC STUDIES OR THIS ASSAY ISN'T GOOD ENOUGH IN", "iAHluJapkkE-00233-00137366-00137877": "TERMS OF TRYING TO PRIORITIZE DRUGS. IT GIVES US AN ABILITY TO PUT SOME CONTEXT", "iAHluJapkkE-00234-00137877-00138658": "IN TO WHETHER A GENOMIC DISCOVERY APPROACH IS LIKELY TO HAVE HIGH UTILITY OR LOW YIELD", "iAHluJapkkE-00235-00138658-00139012": "EXERCISE. THIS SORT OF DATA REALLY SHOULD BE GENERATED", "iAHluJapkkE-00236-00139012-00139455": "FOR EVERY ASPECT OF PHARMACOGENETIC NOT BY US, I'M NOT TRYING TO PLUG THAT WE SHOULD", "iAHluJapkkE-00237-00139455-00139796": "DO IT ALL. PLEASE, I DO NOT WANT THAT.", "iAHluJapkkE-00238-00139796-00140363": "I DO THINK THAT QUESTION THAT NEEDS TO BE ASKED IS REALLY, IS GENETICS LIKELY TO GIVE", "iAHluJapkkE-00239-00140363-00140926": "US THE ANSWER WE WANT. AND CAN WE PRIORITIZE THIS.", "iAHluJapkkE-00240-00140926-00141397": "USING THESE FAMILIES, DO GOOD OLD FASHIONED LINKAGE ANALYSIS.", "iAHluJapkkE-00241-00141397-00141915": "THERE ARE FOLKS THAT REMEMBER HOW TO DO THAT KIND OF THICK.", "iAHluJapkkE-00242-00141915-00142759": "IT'S GOTTEN TRENDY TO DO GENOME WIDE -- LOT OF THE YOUNG FOLKS DON'T KNOW ABOUT THAT EXCEPT", "iAHluJapkkE-00243-00142759-00143357": "FOR THEIR HISTORY. WE CAN GO LOOK ACROSS THE GENOME MORE IMPORTANTLY", "iAHluJapkkE-00244-00143357-00143719": "WE CAN LOOK WITHIN FAMILIES OF ANTI-CANCER DRUGS.", "iAHluJapkkE-00245-00143719-00144452": "TAKE FAMILY OF DRUGS WHERE THERE IS A MULTIPLE MEMBERS THAT ARE USED CLINICALLY, THAT ARE", "iAHluJapkkE-00246-00144452-00145040": "WITHIN THE SAME CHEMICAL CLASS. SO IN THIS CASE TWO OF THE -- THERE ARE EXAMPLES,", "iAHluJapkkE-00247-00145040-00145667": "SUCH AS THIS BOX HERE, OF PEAK, IS THAT WHERE THERE SEEMS TO BE SOME LEVEL OF ASSOCIATION,", "iAHluJapkkE-00248-00145667-00146257": "NOT VERY HIGH LEVEL OF ASSOCIATION BETWEEN CELLULAR TOXICITY AND THIS REGION OF THE GENOME.", "iAHluJapkkE-00249-00146257-00146852": "THEN THERE ARE OTHER AREAS WHERE THERE'S RATHER HIGH LEVEL PEAK, AT LEAST FOR THIS CELL SYSTEM", "iAHluJapkkE-00250-00146852-00147469": "IN BOTH MEMBERS OF THIS FAMILY. WE HAVE EXAMPLES, WITH THE -- WHERE WE WERE", "iAHluJapkkE-00251-00147469-00148267": "ABLE TO GO AND PULL OUT PEAK, IS THAT WERE COMMON TO THE INITIAL SIX CLINICALLY USED,", "iAHluJapkkE-00252-00148267-00148689": "THAT WE HAVE. THEN GO INVALIDATE THAT, THOSE FINDINGS WITH", "iAHluJapkkE-00253-00148689-00149616": "ADDITIONAL -- TO TRY TO LOOK AT REPLICATION OF THESE AND ARE FINDING PEAKS THAT ARE NOT", "iAHluJapkkE-00254-00149616-00150258": "AT PLACE WHERE WE HAVE KNOWN TARGET BUT SEEM TO REPLICATE ACROSS THE FAMILY FOR THIS AREA.", "iAHluJapkkE-00255-00150258-00150923": "ONE CAN LOOK UNDER THESE QUANTITATIVE TRAIT LOCI START TO ASK THE QUESTION, WHYS THERE", "iAHluJapkkE-00256-00150923-00151498": "AN ASSOCIATION BETWEEN THIS REGION OF THE GENOME AND CYTOTOXICITY FOR THIS FAMILY OF", "iAHluJapkkE-00257-00151498-00151763": "DRUGS. OF COURSE WE HAVE THE PROBLEM THAT WE ALWAYS", "iAHluJapkkE-00258-00151763-00152336": "HAVE WHERE THERE IS EXPRESSION ARRAYS OR LINKAGE ANALYSIS OR GENOME WIDE ASSOCIATION ANALYSIS", "iAHluJapkkE-00259-00152336-00152813": "WHERE YOU PUT TOGETHER YOUR LIST OF GENES UNDER A PARTICULAR REGION OF THE GENOME THEY", "iAHluJapkkE-00260-00152813-00153261": "ALL HAVE THE PERFECT STORY. FOR WHY THEY ARE THE RIGHT ONE.", "iAHluJapkkE-00261-00153261-00153608": "THIS IS THE START OF A LOT OF WORK NOT THE END OF A LOT OF WORK.", "iAHluJapkkE-00262-00153608-00154266": "THANKFULLY WE WE HAVE LIBRARY WHERE WE HAVE FIVE CLONES FOR EVERY KNOWN GENE WE'RE TO", "iAHluJapkkE-00263-00154266-00154986": "STAND THROUGH USING CELL-BASED SYSTEMS TO TRY TO IDENTIFY WHICH GENES UNDER THE QTL", "iAHluJapkkE-00264-00154986-00155416": "ARE IMPORTANT. BUT THIS CONCEPT OF NARROWING THE GENOME DOWN", "iAHluJapkkE-00265-00155416-00155922": "FROM LOT OF GENES DOWN TO FOCUS NUMBER OF GENES TO TRY TO DO NEW DISCOVERIES IN TERMS", "iAHluJapkkE-00266-00155922-00156507": "OF MECHANISM OF ACTION IS ONE WAY OF TRYING TO REVISIT THIS IMPORTANT AREA.", "iAHluJapkkE-00267-00156507-00156904": "THIS IS NO SURPRISE, APPROACH I LAID OUT ONE THAT HAS BEEN USED FOR YEARS WITH DISEASE.", "iAHluJapkkE-00268-00156904-00157398": "BUT PHARMACOGENETIC IS DEVELOPED OUT OF CLINICAL PHARMACOLOGY.", "iAHluJapkkE-00269-00157398-00158138": "VERY FEW GENETICIST ARE APPLYING STRONG GENETIC TECHNIQUES TO PHARMACOGENETIC.", "iAHluJapkkE-00270-00158138-00158717": "PEOPLE LIKE ME WHO REALLY KNOW MORE ABOUT PHARMACOTHAN THEY DO GENOMICS ARE GRADUALLY", "iAHluJapkkE-00271-00158717-00159276": "LEARN KNOWLEDGE AS OUR GEE NET PARTICULARS AND GENOMICS COLLEAGUES TEACH US MORE HOW", "iAHluJapkkE-00272-00159276-00159925": "TO APPLY THIS IN THE PROPER WAY. THE OTHER ASPECT I WANT TO BRIEFLY TOUCH ON", "iAHluJapkkE-00273-00159925-00160724": "IS THERE'S BEEN SOME GROWTH IN MOUSE MODEL SYSTEM THAT REALLY ARE STARTING TO OPEN UP", "iAHluJapkkE-00274-00160724-00162001": "THE MOUSE AS STRONG GENETIC TOOL. IN TERMS OF THE VARIABILITY WITHIN STRAINS", "iAHluJapkkE-00275-00162001-00162701": "OF MICE. MORE RECENTLY THE COLLABORATIVE HAS COME FORWARD", "iAHluJapkkE-00276-00162701-00164466": "INITIALLY -- IN CHAPEL HILL. WHERE SEVERAL OF THE MORE DISPARTY DISPIRIT", "iAHluJapkkE-00277-00164466-00165048": "A THOUSAND NEW UNIQUE STRAINS OF MICE THAT ARE NOW AVAILABLE.", "iAHluJapkkE-00278-00165048-00165912": "THAT ARE AT OR GREATER THAN AMOUNT OF GENETIC VARIABILITY SEEN ACROSS THE HUMAN POPULATION", "iAHluJapkkE-00279-00165912-00166560": "ACROSS THE GLOBE. SO INSTEAD OF HAVING 32 STRAINS -- OF MOUSE", "iAHluJapkkE-00280-00166560-00167208": "IN WHICH TO DO STUDIES WE NOW HAVE THE EQUIVALENT OF A THOUSAND PERSON STUDY IN WHICH TO DO", "iAHluJapkkE-00281-00167208-00167548": "DISCOVERY. THEY'RE VERY REPRODUCIBLE, THEY ARE INBRED", "iAHluJapkkE-00282-00167548-00168424": "AND FIXED IN TERMS OF GENETICS AND THERE IS A CURRENT EFFORT TO COMPLETE THE ENTIRE GENOMES", "iAHluJapkkE-00283-00168424-00169474": "OF ALL THESE MICE WITH THE -- SO THAT THEISM'S STRAINS HAVE THE ENTIRE GENOME LAID OUT FOR", "iAHluJapkkE-00284-00169474-00170003": "YOU YOU CAN GO IN TO YOUR PHENOTYPING THEN ASK QUESTIONS.", "iAHluJapkkE-00285-00170003-00170713": "FOR EXAMPLE, ONE CAN TAKE HIGH DENSITY IMAGING SYSTEM WHICH YOU CAN LOOK AT VARIOUS PHENOTYPES,", "iAHluJapkkE-00286-00170713-00171426": "THESE ARE TIM'S FANCY GRAPHICS. USE CONTENT IMAGING SYSTEM TO LOOK AT NUMBER", "iAHluJapkkE-00287-00171426-00172004": "OF DIFFERENT CELLULAR FEATURES SO IN THIS CASE WE'RE LOOKING AT THE AFFECT OF DRUG ON", "iAHluJapkkE-00288-00172004-00172563": "CELL LOSS, TOTAL NUCLEAR INTENSITY, PEOPLE I CAN'TABILITY, MEMBRANE POTENTIAL, CYTOCHROME", "iAHluJapkkE-00289-00172563-00173074": "C. OTHER MEASURES CAN BE DONE.", "iAHluJapkkE-00290-00173074-00173862": "YOU CAN SAY THESE STRAINS OF MICE, EITHER IN THIS CASE USING THE MOUSE FIBROBLAST OR", "iAHluJapkkE-00291-00173862-00174447": "USING MORE CLASSICAL IN VIVO ASSAYS AND TRY TO DO DISCOVERY IN THAT CASE.", "iAHluJapkkE-00292-00174447-00175348": "FOR EXAMPLE, WE HAVE REGION OF THE GENOME THAT CAME OUT FROM THE TAXANE FROM OUR CEPH", "iAHluJapkkE-00293-00175348-00176167": "EXPERIMENT. THE REGION OF THE GENOME FROM THE MOUSE FIBROBLAST", "iAHluJapkkE-00294-00176167-00176889": "EXPERIMENT THAT OVERLAPS IN TERMS OF -- AND SO TWO INDEPENDENT MAMMALIAN SYSTEMS BOTH", "iAHluJapkkE-00295-00176889-00177492": "POINTING TO VERY NARROW REGION OF THE GENOME IN WHICH THERE'S A SINGLE GENE THAT HAD NOT", "iAHluJapkkE-00296-00177492-00177974": "BEEN IMPLY CANADA IN THE ACTIVITY OF THIS DRUG BUT DOES HAVE BIOLOGIC PLAUSIBILITY.", "iAHluJapkkE-00297-00177974-00178687": "WE'RE NOW DOING THE EXPERIMENTS TO NAIL DOWN IF GENE IS REGULATOR OF ITS AFFECT.", "iAHluJapkkE-00298-00178687-00179126": "BUT THE IDEA OF DOING DISCOVERY IN MULTIPLE MAMMALIAN SYSTEMS IN RELATIVELY HIGH THROUGHPUT", "iAHluJapkkE-00299-00179126-00179961": "MANNER AND LOOK AT COMMONALITY IS REALLY I THINK LOT OF POTENTIAL IN TERMS OF ITS DISCOVERY.", "iAHluJapkkE-00300-00179961-00181486": "[ NOT AUDIBLE ] SORRY, I WAS GOING TOO FAST.", "iAHluJapkkE-00301-00181486-00181786": "IN THIS EXPERIMENT -- [ NOT AUDIBLE ]", "iAHluJapkkE-00302-00181786-00182308": "YOU CAN MAKE AS MANY AS YOU WANT. IN THIS CASE WE MAKE ONE SET OF MOUSE EMBRYO", "iAHluJapkkE-00303-00182308-00183347": "FIBROBLASTS FROM THE --", "iAHluJapkkE-00304-00183347-00183548": "[ NOT AUDIBLE ] I DON'T KNOW THE ANSWER TO THAT.", "iAHluJapkkE-00305-00183548-00184084": "I KNOW LOCALLY WE HAVE CELL LINES. AS I UNDERSTAND IT THESE MICE WILL BE AVAILABLE", "iAHluJapkkE-00306-00184084-00185000": "TO THE COMMUNITY THIS WAS PAID FOR BY NIH, DOD AND DOE MONEY AND THESE MICE I BELIEVE", "iAHluJapkkE-00307-00185000-00185535": "WILL BE WIDELY AVAILABLE AS A RESOURCE FROM THAT.", "iAHluJapkkE-00308-00185535-00186047": "[ NOT AUDIBLE ] WE DIDN'T DO THE EXPERIMENT FOR TWO REASONS.", "iAHluJapkkE-00309-00186047-00186650": "ONE MANY OF THESE ARE -- USUALLY IF YOU MEASURE ONE PHENOTYPE.", "iAHluJapkkE-00310-00186650-00187039": "SECONDLY, COST. WITH THE CELL LINES WE CAN QUICKLY GO THROUGH", "iAHluJapkkE-00311-00187039-00187749": "YOU CAN -- VERY RAPIDLY ASSAY ALL 1,000 CELL LINES IN VERY RAPID MANNER.", "iAHluJapkkE-00312-00187749-00188136": "THIS DATA ONLY SHOWING 32, BY THE WAY. I DON'T WANT TO OVER SELL THIS PARTICULAR", "iAHluJapkkE-00313-00188136-00188439": "SLIDE. ONE CAN LOOK AT LARGE NUMBER IN VERY HAPPIED", "iAHluJapkkE-00314-00188439-00188865": "MANNER. WITH THE ROBOT THINGS WE HAVE AND PLATING", "iAHluJapkkE-00315-00188865-00189435": "SYSTEM WE HAVEN'T USED 1536, ONE COULD. YOU CAN SCAN THROUGH A THOUSAND CELL LINES", "iAHluJapkkE-00316-00189435-00189955": "IN A PRETTY QUICK MANNER. WHEN I WAS A POST DOC IF I HAD FIVE CELL LINES", "iAHluJapkkE-00317-00189955-00190373": "TO WORK WITH I'D FREAK OUT. NOW WE HAVE TECHNICIANS THAT DON'T KNOW ANY", "iAHluJapkkE-00318-00190373-00190672": "BETTER. KEY THING IS HIRE SOMEONE WHO DOESN'T KNOW", "iAHluJapkkE-00319-00190672-00191636": "ANYTHING BECAUSE THEY THINK A THOUSAND CELL LINES, THAT DOESN'T SEEM LIKE VERY MANY.", "iAHluJapkkE-00320-00191636-00192072": "[ NOT AUDIBLE ] THE NICE THING ABOUT THESE MOUSE STRAINS IS", "iAHluJapkkE-00321-00192072-00192835": "BECAUSE OF THE GENOMICS SO WELL CHARACTERIZED IN TERMS OF VARIANTS AND COPY NUMBER WE NOW", "iAHluJapkkE-00322-00192835-00193335": "KNOW WHICH CELL LINES -- WHICH MICE WE CAN GO BACK IN TO FOR THOSE INITIAL EXPERIMENTS", "iAHluJapkkE-00323-00193335-00194033": "I'LL SHOW YOU WE HAVE LARGE CLINICAL TRIAL COHORTS SO IF WE DEMONSTRATE THIS -- CREDENTIAL", "iAHluJapkkE-00324-00194033-00194817": "A GENE TO BE OF RELEVANCE WITH OUR CELL BASE SYSTEM WE CAN QUICKLY TAKE THE VARIANTS THAT", "iAHluJapkkE-00325-00194817-00195680": "ARE FUNCTIONAL CONSEQUENCE TO THOSE STUDIES THEN TAKE IT IN TO OUR CLINICAL MATERIAL.", "iAHluJapkkE-00326-00195680-00196304": "[ NOT AUDIBLE ] THESE ARE INBRED STRAINS.", "iAHluJapkkE-00327-00196304-00196974": "THEY WEREN'T DONE QUICKLY. THE QUESTION WAS, HOW CAN WE MAKE THEM INBRED", "iAHluJapkkE-00328-00196974-00197377": "QUICKLY. THE ANSWER IS, YOU CANNOT.", "iAHluJapkkE-00329-00197377-00197985": "THERE ARE OUT ABOUT 25 GENERATIONS NOW. THERE'S NO QUICK WAY OF DOING INBRED MOUSE", "iAHluJapkkE-00330-00197985-00198205": "STRAINS. NOTHING'S CHANGED THERE.", "iAHluJapkkE-00331-00198205-00198584": "YOU DIDN'T MISS ANYTHING. STILL AS SLOW AS IT ALWAYS IS, JUST THAT IT'S", "iAHluJapkkE-00332-00198584-00199130": "BEEN DONE NOW. THERE'S LOT THAT CAN BE DONE IN TERMS OF DISCOVERY.", "iAHluJapkkE-00333-00199130-00199633": "THOSE OF YOU ON THE DISCOVERY SIDE MAYBE GET CAN TIRED OF WORKING ON DISEASE DISCOVERY", "iAHluJapkkE-00334-00199633-00200098": "COME OVER TO PHARMACOGENOMICS, THE WATER'S FINE, COME ON IN.", "iAHluJapkkE-00335-00200098-00200491": "WE NEED A LOT OF HELP. WE HAVE A LOT OF DRUGS THAT ARE OUT THERE", "iAHluJapkkE-00336-00200491-00201029": "AND BUNCH OF DRUGS THAT ARE COMING IN TO DEVELOPMENT AND WE DON'T HAVE A CLUE HOW TO USE THEM.", "iAHluJapkkE-00337-00201029-00201850": "SO THERE'S A LOT OF WORK STILL TO BE DONE USING EVEN APPROACHES THAT ARE OLD TRIED AND", "iAHluJapkkE-00338-00201850-00202578": "TRUE BUT HOPEFULLY HELP US GO FORWARD. THE SECOND ISSUE I WANTED TO HIT ON WAS VALIDATION", "iAHluJapkkE-00339-00202578-00202966": "IN ROBUST DATA SETS. TOO OFTEN WHAT HAPPENS YOU DO REALLY COOL", "iAHluJapkkE-00340-00202966-00203435": "DISCOVERY IN THE LABORATORY AND THEN YOU TO GO YOUR FAVORITE CLINICIAN THAT YOU HAVE TEA", "iAHluJapkkE-00341-00203435-00204069": "WITH ON THURSDAY YOU SAY, YOU GOT ANY DNA? THEY SAY, YEAH, WE HAVE 42 SAMPLES THAT WE'VE", "iAHluJapkkE-00342-00204069-00204672": "CONSENTED THE PATIENT WE HAVE TOXICITY PHENOTYPE AND SO YOU GENOTYPE YOUR FAVORITE SNP AND", "iAHluJapkkE-00343-00204672-00205221": "GENE ALL 42 SAMPLES AND BOTH HETEROZYGOTES HAD TOXICITY AND NO ONE ELSE DID, EVERYONE", "iAHluJapkkE-00344-00205221-00206036": "SHOULD BE TESTED FOR THE GENE. THERE ARE PILES OF LITERATURE ALONG THIS SAME", "iAHluJapkkE-00345-00206036-00206555": "LINE INCLUDING SOME FROM OURSELF WHERE WE HAVE DONE THESE TYPES OF EXPERIMENTS.", "iAHluJapkkE-00346-00206555-00207069": "THEY WERE USEFUL EARLY ON TO DEMONSTRATE THE ONE COULD DO THESE.", "iAHluJapkkE-00347-00207069-00207600": "BUT THEY ARE COMPLETELY USELESS WHEN IT COMES TO CHANGING PRACTICE.", "iAHluJapkkE-00348-00207600-00208305": "THE ONLY THING THEY'RE USEFUL FOR NOWADAYS IS TO TRY TO EXPAND ONE'S CV AND POTENTIALLY", "iAHluJapkkE-00349-00208305-00209002": "GET PROMOTION. IT HAS NO USEFULNESS FOR HELPING FELLOW MAN.", "iAHluJapkkE-00350-00209002-00209476": "TRYING TO DO THE RIGHT STUDIES IS VERY HARD. REASON YOU DO THE 42 PATIENT STUDIES, WE DID", "iAHluJapkkE-00351-00209476-00209969": "THEM IT WAS CONVENIENT. WE HAD TUMORS AND TUMOR BANK.", "iAHluJapkkE-00352-00209969-00210477": "WE HAD CLINICAL TRIAL SAM PELTS SITTING THERE. BUT IT DOESN'T MEAN THAT IT'S ACTUALLY GOING", "iAHluJapkkE-00353-00210477-00210996": "TO BE USEFUL. WHAT WE'VE DONE IN CONTEXT OF THE NCI COOPERATIVE", "iAHluJapkkE-00354-00210996-00211515": "GROUPS, MAINLY THE CANCER AND LEUKEMIA GROUP B OR -- DEPENDING HOW YOU LIKE TO CALL IT", "iAHluJapkkE-00355-00211515-00212200": "IS TO GO IN START INTEGRATING BLOOD SAMPLING WHEN POSSIBLE TUMOR SAMPLING IN TO THE PROSPECTIVE", "iAHluJapkkE-00356-00212200-00212601": "CLINICAL TRIAL. IT'S RATHER THAN HAVING 46 BREAST CANCER PATIENTS", "iAHluJapkkE-00357-00212601-00213252": "FROM CHAPEL HILL WE HAVE 4,600 BREAST CANCER PATIENTS ALL ON PROSPECTIVE CLINICAL TRIAL", "iAHluJapkkE-00358-00213252-00214060": "WITH AUDITING OF THE EVALUATION OF TOXICITY AND EFFICACY INDEPENDENT IMAGING EVALUATION,", "iAHluJapkkE-00359-00214060-00214717": "THESE STUDIES WERE DONE, OR BEING DONE OVER 200 CENTERS ACROSS THE U.S. AND CANADA.", "iAHluJapkkE-00360-00214717-00215206": "SO WE HAVE THE SORT OF NORMAL VARIABILITY IN TERMS OF THE VARIOUS CENTERS THAT YOU WOULD", "iAHluJapkkE-00361-00215206-00215559": "WANT IN TERMS OF TRYING TO PROVE SOMETHING BEING USEFUL.", "iAHluJapkkE-00362-00215559-00216104": "HAVING THESE NUMBERS, THEY'RE NOT ALL LARGE NUMBERS, BUT HAVING THIS SORT OF DATA FROM", "iAHluJapkkE-00363-00216104-00216728": "PROSPECTIVE STUDIES, EVEN IFER WE'RE DOING RETROSPECTIVE LOOK AT THE EVALUATION OF THE", "iAHluJapkkE-00364-00216728-00217277": "MARKERS, ALLOWS US TO HAVE MUCH MORE ROBUST CONCLUSION ABOUT WHETHER MARKER IS LIKELY", "iAHluJapkkE-00365-00217277-00217876": "TO BE OF USE OR WHETHER IT'S JUST SOMETHING THAT IS UNIQUE TO CHAPEL HILL.", "iAHluJapkkE-00366-00217876-00218471": "WE'VE CERTAINLY SEEN IN THE PAST MANY MARKERS THAT SEEM TO BE RELEVANT IN ONE PARTICULAR", "iAHluJapkkE-00367-00218471-00218959": "CENTER, BUT JUST DO NOT REPLICATE WHEN YOU TAKE THEM OUT ACROSS DIFFERENT PLACES.", "iAHluJapkkE-00368-00218959-00219630": "OFTEN IT'S A PROTEIN BIOMARKER, ON FURTHER EVALUATION WHAT YOU FIND OUT IS THAT THAT", "iAHluJapkkE-00369-00219630-00219988": "PARTICULAR INVESTIGATE OR ONLY HAS HIS CLINIC ON TUESDAY MORNINGS.", "iAHluJapkkE-00370-00219988-00220565": "IT'S THE SAME LAB TECH, IS THAT ARE RUNNING EVERYTHING, THE SAME NURSES, THERE'S LEVEL", "iAHluJapkkE-00371-00220565-00221091": "OF HOMOGENEITY THAT ENDS UP INFLUENCING THINGS IN WAYS THAT WE DON'T UNDERSTAND.", "iAHluJapkkE-00372-00221091-00221944": "BUT LEAD TO LACK OF REPLICATION. HAVING THESE DATA SETS ACROSS THE COUNTRY", "iAHluJapkkE-00373-00221944-00222561": "WE CAN HOPEFULLY GET A BETTER CONCLUSION ON WHETHER A MARKER IS TRULY USEFUL OR TRULY", "iAHluJapkkE-00374-00222561-00223027": "USELESS. TOO OFTEN THE PHARMACOGENETIC LITERATURE HAS", "iAHluJapkkE-00375-00223027-00223417": "BEEN NEITHER. IT'S BEEN PROMISING.", "iAHluJapkkE-00376-00223417-00224148": "THE BIGGEST COP OUT IN SCIENCE IS PAPER WHERE THE LAST CONCLUSION IS, FURTHER RESEARCH IS", "iAHluJapkkE-00377-00224148-00224526": "NEEDED. COMPLETE COP OUT.", "iAHluJapkkE-00378-00224526-00225096": "WHAT IT MEANS IS, WE DIDN'T DO THE RIGHT STUDY. IN SOME CASES YOU CAN'T DO THE RIGHT STUDY,", "iAHluJapkkE-00379-00225096-00225563": "THE CLINICAL DATA SET IS NOT AVAILABLE OR MICE AREN'T AVAILABLE OR CELLS AREN'T AVAILABLE.", "iAHluJapkkE-00380-00225563-00226209": "BUT IN MOST CASES WHERE THAT CONCLUSION IS THERE, IT'S BECAUSE WE REALLY DIDN'T DO THE", "iAHluJapkkE-00381-00226209-00226558": "RIGHT STUDY. WHAT WE'RE TRYING TO DO, NOT SUCCEEDING IN", "iAHluJapkkE-00382-00226558-00227180": "EVERY CASE IS GET IN TO THE POSITION WHERE WE CAN DO DEFINITIVE STUDIES EITHER PUT SOMETHING", "iAHluJapkkE-00383-00227180-00227969": "TO REST OR CAUSE US TO GO FORWARD IN TO PATIENT DIRECTED THERAPY USING THESE SORT OF MARKERS.", "iAHluJapkkE-00384-00227969-00228703": "ONE OF THE EXAMPLES I HAVE IS FOR OVARIAN CANCER STUDY, IT'S CALLED THE -- THIS IS CONDUCTED", "iAHluJapkkE-00385-00228703-00229492": "IN SCOTLAND NOT IN THE U.S. BUT IT'S EXAMPLE OF PAPER WE'VE JUST ARE SENDING", "iAHluJapkkE-00386-00229492-00229948": "TO A PRESTIGIOUS BOSTON-BASED JOURNAL, MAY NOT GET ACCEPTED THERE BUT WE'LL START THERE.", "iAHluJapkkE-00387-00229948-00230646": "AND IN THIS STUDY WHAT WAS FOUND IS THAT THE OUTCOMES -- SORRY, THIS STUDY LOOKED AT THE", "iAHluJapkkE-00388-00230646-00231301": "COMMON THERAPIES FOR OVARIAN CANCER. CAR BOW PLATINUM, THE ACHE WAS COMMON TO BOTH", "iAHluJapkkE-00389-00231301-00231923": "ARMS THEN ONE OF THE TACK IN A TWINS EITHER DOSE TACKLE OR PACLITAXEL WERE USED.", "iAHluJapkkE-00390-00231923-00234242": "THESE ARE VERY SIMILAR TO EACH OTHER.", "iAHluJapkkE-00391-00234242-00235051": "WHAT ONE BE THEN DO -- THE MAIN TOXICITY THAT WAS SCENE IN BOTH ARM WAS TOXICITY TO THE", "iAHluJapkkE-00392-00235051-00235329": "ARMS. AS I MENTIONED BEFORE, MANY OF THE PLATINUM", "iAHluJapkkE-00393-00235329-00235773": "CONTAINING REGIMENS WILL CAUSE PERIPHERAL NEUROPATHY.", "iAHluJapkkE-00394-00235773-00236230": "IT'S A BIG DEAL. AFFECTS THE PATIENT'S QUALITY OF LIFE.", "iAHluJapkkE-00395-00236230-00236921": "ANY OF YOU WHO HAVE EVER BEEN TO AN OVARIAN CANCER CLINIC OR HAVE HAD FRIEND OR LOVED", "iAHluJapkkE-00396-00236921-00237594": "ONE WITH OVARIAN CANCER, HAVE BEEN THERE, YOU'LL SEE NUMBER OF WOMEN WITH WALKERS.", "iAHluJapkkE-00397-00237594-00237969": "THESE AREN'T NECESSARILY OLD WOMEN BUT THEY'RE USING A WALK TORE TRY TO GET AROUND.", "iAHluJapkkE-00398-00237969-00238202": "THE REASON WHY IS THAT THE DRUGS HAVE FRIED THEIR NERVES.", "iAHluJapkkE-00399-00238202-00238580": "THEY CAN'T EVEN WALK NORMALLY BECAUSE OF THESE DRUGS.", "iAHluJapkkE-00400-00238580-00239003": "IT MIGHT BE CONTROLLING THEIR DISEASE BUT ALSO REALLY AFFECTING THEIR NERVES IN A NEGATIVE", "iAHluJapkkE-00401-00239003-00239352": "WAY. WE WANTED TO ASK QUESTION, WHY, CAN WE PREDICT", "iAHluJapkkE-00402-00239352-00239707": "THIS IN A BETTER MANNER. REALLY WAS NOT KNOWN.", "iAHluJapkkE-00403-00239707-00240581": "WE DID AT THAT POINT A CUSTOM CHIP TAKING GENES INVOLVED WITH NERVE FUNCTION, GENES", "iAHluJapkkE-00404-00240581-00241225": "INVOLVED WITH INHERITED NEUROPATHIES REALIZING THAT THE VARIANTS FOUND IN -- WHATEVER WILL", "iAHluJapkkE-00405-00241225-00241463": "NOT BE THOSE VARIANTS THOSE ARE EXTREMELY RARE.", "iAHluJapkkE-00406-00241463-00242041": "MAYBE NOR COMMON VARIANTS MIGHT HAVE FUNCTIONAL CONSEQUENCE THEN GENES INVOLVED IN THE -- KNOWN", "iAHluJapkkE-00407-00242041-00242473": "TO BE INVOLVED WITH THE PHARMACOLOGY EVER THESE DRUGS REALIZING THE CAVEAT, IS THAT", "iAHluJapkkE-00408-00242473-00243119": "I SAID EARLIER WHEN I WAS RIDICULING MY LACK OF KNOWLEDGE ABOUT DRUGS.", "iAHluJapkkE-00409-00243119-00244119": "LOOKING AT THESE CASES, TO TRY TO LOOK AT PREDICTORS OF NEUROTOXICITY IN THIS PATIENT", "iAHluJapkkE-00410-00244119-00244537": "POPULATION. WE STARTED OFF OUT OF THE 1536 SNPS THAT WERE", "iAHluJapkkE-00411-00244537-00245089": "AVAILABLE. THERE WERE 1261 THAT MET OUR QUALITY ASSESSMENT.", "iAHluJapkkE-00412-00245089-00245973": "MANY -- SOME OF THEM WERE TOO FAR OUT TO BE BELIEVABLE.", "iAHluJapkkE-00413-00245973-00246535": "THERE WERE OTHERS WHERE THERE WERE CONTROLLED ISSUES IN TERMS OF THE GENOTYPES.", "iAHluJapkkE-00414-00246535-00247375": "OF THESE 1261 SNPS WE LOOKED AT COHORT OF 500 PATIENTS, THERE WERE 69 THAT CAM OUT TO", "iAHluJapkkE-00415-00247375-00248259": "BE POSITIVE AFTER MULTIPLE -- MULTIPLE COMPARISON CORRECTION FOR THIS INITIAL COHORT.", "iAHluJapkkE-00416-00248259-00248885": "WE TOOK THESE 69 SNPS IN TO A SECOND COHORT OF RADIO 0 WOMEN ON THE SAME THERAPY AND THERE", "iAHluJapkkE-00417-00248885-00249666": "WERE FIVE OF THEM, FIVE SNPS THAT WERE STILL STATISTICALLY SIGNIFICANT AFTER COMPARISON.", "iAHluJapkkE-00418-00249666-00250223": "FOUR WERE IN CONSISTENT DIRECTION. THERE WAS ONE OF THEM THAT WAS POSITIVE PREDICTOR", "iAHluJapkkE-00419-00250223-00250877": "IN THE FIRST DATA SET, SECOND IN THE -- TWO WRONGS DO NOT MAKE A RIGHT.", "iAHluJapkkE-00420-00250877-00251419": "THAT VARIANT GOT TOSSED OUT. WE ENDED UP WITH FOUR VARIANTS THAT LOOKED", "iAHluJapkkE-00421-00251419-00252130": "OF INTEREST. WHEN YOU LOOK AT THESE GENES, SOME OF THE", "iAHluJapkkE-00422-00252130-00252858": "OTHER -- THAT GENE YOU CAN MAKE STORY IN TERMS. SOME OF THESE OTHERS ARE NOT OBVIOUS STORY", "iAHluJapkkE-00423-00252858-00253326": "EXCEPT FOR THEIR INVOLVEMENT IN NERVE FUNCTION OR IN PERIPHERAL NEUROPATHY SYNDROME.", "iAHluJapkkE-00424-00253326-00254017": "THE ODDS RATIOS WERE BETWEEN 2.2 AND FOUR. TYPE OF ODDS RATIOS THAT YOU PAY ATTENTION", "iAHluJapkkE-00425-00254017-00254617": "TO CLINICALLY, NONE OF THESE ODDS RATIOS OF 1.15 THAT WE DON'T HAVE CLUE WHAT TO DO WITH.", "iAHluJapkkE-00426-00254617-00255051": "ODDS RATIOS THAT YOU WOULD CARE ABOUT IN TERMS OF INDIVIDUAL MARKERS.", "iAHluJapkkE-00427-00255051-00255558": "WE LOOK AT POPULATION OF ATTRIBUTABLE RISK. YOU PUT THEM ALL TOGED ALMOST 85%.", "iAHluJapkkE-00428-00255558-00256557": "A VERY SUBSTANTIAL AMOUNT OF RISK IN TERMS OF POTENTIAL -- THEN WE DO THIS, THE SIMPLE", "iAHluJapkkE-00429-00256557-00257002": "THING THAT PEOPLE DO THESE DAYS WHEN YOU BASICALLY MAKE A SCORE WHERE YOU ADD UP THE NUMBER OF", "iAHluJapkkE-00430-00257002-00257808": "BAD VARIANTS THAT A PERSON HAS, IN THIS CASE IT WENT FROM ZERO TO FOUR, THIS IS SHOWING", "iAHluJapkkE-00431-00257808-00258358": "MAPPING EVER THE ODDS RATIO, I REALIZE VERY STEEP RISE HERE, CURVE MAKES IT LOOK MUCH", "iAHluJapkkE-00432-00258358-00258738": "SMOOTHER BUT THAT'S WHAT OUR STATISTICIAN GAVE US.", "iAHluJapkkE-00433-00258738-00259444": "THERE WAS ADDITIVE OR IN THIS CASE SUPER ADDITIVE AFFECT DEPENDING ON THE NUMBER OF VARIANTS", "iAHluJapkkE-00434-00259444-00259877": "YOU HAD ASSOCIATING WITH THE RISK OF PERIPHERAL NEUROPATHY.", "iAHluJapkkE-00435-00259877-00260556": "THE FOLKS WITH FOUR OF THESE VARIANTS HAD ODDS RATIO OF OVER 40 IN THIS PARTICULAR STUDY", "iAHluJapkkE-00436-00260556-00260930": "IN TERMS OF THEIR RISK OF HAVING PERIPHERAL NEUROPATHY.", "iAHluJapkkE-00437-00260930-00261434": "WE ALSO ASKED THE QUESTION, DO THESE RISKS SCORES ASSOCIATE WITH OUTCOME.", "iAHluJapkkE-00438-00261434-00262021": "THE OLD TEACHING FOR CANCER CHEMOTHERAPY WAS YOU NEEDED TO NEARLY KILL THE PATIENT IN ORDER", "iAHluJapkkE-00439-00262021-00262705": "TO KILL THE TUMOR. BACK WHEN THE DRUGS WERE CYTOTOXICS, THAT", "iAHluJapkkE-00440-00262705-00263015": "WAS PROBABLY TRUE. IN MODERN THERAPY THAT IS NOT TRUE.", "iAHluJapkkE-00441-00263015-00263638": "THERE'S STUDY AFTER STUDY DEMONSTRATING THAT SEVERITY OF TOXICITY HAS NO RELATIONSHIP WITH", "iAHluJapkkE-00442-00263638-00264350": "THE DEGREE OF EFFICACY FOR WHETHER IT'S KINASE INHIBITOR OR ONE OF THE CYTOTOXICS SUCH AS", "iAHluJapkkE-00443-00264350-00264942": "WAS USED HERE. WE ASK THAT -- THERE WAS NO RELATIONSHIP BETWEEN", "iAHluJapkkE-00444-00264942-00265804": "THEIR NEUROPATHY SCORE WITH THESE GENES AND EITHER THEIR PROGRESSION FREE SURVIVAL OR", "iAHluJapkkE-00445-00265804-00266474": "THEIR OVERALL SURVIVAL IN THIS STUDY. SO, WE ENDED UP WITH FOUR SNPS AND FOUR GENES", "iAHluJapkkE-00446-00266474-00267050": "THAT VALIDATED IN A SEPARATE 500 PATIENT COHORT WITH BIOLOGY THIS WE WOULD NOT HAVE ASSOCIATED", "iAHluJapkkE-00447-00267050-00267622": "DIRECTLY WITH THESE DRUGS, MARKERS WERE ASSOCIATED WITH RISK OF PERIPHERAL NEUROPATHY BUT NOT", "iAHluJapkkE-00448-00267622-00268401": "WITH THE SURVIVAL OR EFFICACY OUTCOME MEASUREMENT. WE NOW HAVE AN OPPORTUNITY TO BOTH TRY TO", "iAHluJapkkE-00449-00268401-00268809": "PROSPECTIVELY SEE WHETHER THESE MARKERS DO PREDICT NEUROPATHY.", "iAHluJapkkE-00450-00268809-00269450": "THAT STUDY IS ONGOING AS WELL AS TAKE THESE GENES PUT THEM THROUGH A SCREEN FOR INHIBITORS.", "iAHluJapkkE-00451-00269450-00270166": "WE HAVE ONE OF THE NIGMS SCREENING CENTERS AT UNC SO THEY ARE SCREENING LARGE LIBRARY", "iAHluJapkkE-00452-00270166-00270671": "OF COMPOUNDS AGAINST THESE GENES. THAT'S NOT BCL 2.", "iAHluJapkkE-00453-00270671-00271311": "USING OTHER THREE GENES TRYING TO IDENTIFY INHIBITORS TO SEE WHETHER THEY MIGHT BE POTENTIAL", "iAHluJapkkE-00454-00271311-00271978": "ADJUVANTS TO BE USED WITH THIS CHEMOTHERAPY. BASED ON THATTH DATA DEGREE OF NEUROPATHY", "iAHluJapkkE-00455-00271978-00272688": "AND EFFICACY WERE NOT LINKED. IN THEORY, WE CAN INHIBIT THE NEUROPATHY WITHOUT", "iAHluJapkkE-00456-00272688-00273037": "INFLUENCING. THE PROMISE THAT HAVE BEING TRUE.", "iAHluJapkkE-00457-00273037-00273697": "IT WOULD BE GREAT DAY IF WE'RE ABLE TO MINIMIZE THE NEUROPATHY BECAUSE IT IS SO DEBILITATING", "iAHluJapkkE-00458-00273697-00274035": "TO THESE PATIENTS. WE'RE NOT TRYING TO CURE THESE WOMEN WE'RE", "iAHluJapkkE-00459-00274035-00274403": "TRYING TO GIVE THEM BETTER QUALITY OF LIFE FOR THE TIME THEY HAVE LEFT ON THIS EARTH.", "iAHluJapkkE-00460-00274403-00275402": "AND TO SCREW UP THEIR NERVES TO WHERE THEY CAN'T HOLD THEIR GRAND KID IS REALLY NOT OUR", "iAHluJapkkE-00461-00275402-00275723": "GOAL. HOPEFULLY GENETICS, THIS SORT OF DATA WILL", "iAHluJapkkE-00462-00275723-00276184": "LEAD TOWARDS SOME APPROACHES WHERE WE CAN AT THE LEAST KNOW THAT WE'RE GOING TO GET", "iAHluJapkkE-00463-00276184-00276748": "IN TO TROUBLE EARLY. AT THE BEST HAVE SOME INTERVENTIONS THAT CAN", "iAHluJapkkE-00464-00276748-00277384": "MAKE THINGS EVEN BETTER. THE LAST PIECE ON IN TERMS OF ROBUST DATA", "iAHluJapkkE-00465-00277384-00277967": "SETS IS WE'RE USING THESE DATA SETS NOW INITIALLY FOR GENOME WIDE ASSOCIATION STUDY AND WE'VE", "iAHluJapkkE-00466-00277967-00278446": "COMPLETED FOUR GENOME WIDE ASSOCIATION STUDIES TO DATE.", "iAHluJapkkE-00467-00278446-00279081": "FIRST ONE WAS IN PANCREAS CANCER STUDY, PAPER HAS BEEN SUBMITTED TO THE JOURNAL OF CLINICAL", "iAHluJapkkE-00468-00279081-00279843": "ONCOLOGY WHERE LOOKING AT GENETIC PREDICTORS OF BOTH OUTCOMES AS WELL AS TOXICITY TO THE", "iAHluJapkkE-00469-00279843-00280155": "DRUGS. NEUTROPENIA AS WELL AS HYPERTENSION YOU GET", "iAHluJapkkE-00470-00280155-00280944": "FROM SOME OF THE VASCULAR GROWTH FACTOR ANTAGONISTS, WE HAVE TWO GENOME WIDE STUDIES IN THIS AREA,", "iAHluJapkkE-00471-00280944-00281492": "ONE FOR NEUROPATHY, ONE FOR NEUTROPENIA. WE HAVE GENOME WIDE STUDY THAT'S JUST BEEN", "iAHluJapkkE-00472-00281492-00282378": "COMPLETED IN PROSTATE CANCER THAT WE'RE NOW STARTING THE ANALYSIS ON AND DEPENDING WHETHER", "iAHluJapkkE-00473-00282378-00283069": "FRANCIS SMILES OUR WAY WITH THE MOST RECENT DIRECTOR'S GRANT SUBMITTED ON THE 15TH OF", "iAHluJapkkE-00474-00283069-00283735": "MARCH, WE HAVE NEXT GENERAL PROPOSAL TO GO IN USE SOME OF THE FOLKS GENESEE QUEENING", "iAHluJapkkE-00475-00283735-00284375": "OR THE WHOLE APPROACH TO DO STUDY IN CONTECH OF PROSPECTIVE CLINICAL TRIAL.", "iAHluJapkkE-00476-00284375-00285782": "NEXT GENERAL NEXGEN WE ARE STARTING, WE'RE SLOW, THE DISEASE, YOU GO TO THE WEBSITE YOU", "iAHluJapkkE-00477-00285782-00286239": "CAN SEE HUNDREDS OF -- FOR DISEASE VERY FEW ON THE DRUG SIDE, PARTLY BECAUSE WE DIDN'T", "iAHluJapkkE-00478-00286239-00286841": "HAVE THE DATA SET IN WHICH TO GO IN DO DISCOVERY. CLINICAL PHARMACOLOGY 50 PATIENTS IS A HUGE", "iAHluJapkkE-00479-00286841-00287378": "STUDY. IN GWAS IT'S NOT WORTH DOING IT.", "iAHluJapkkE-00480-00287378-00287900": "WE'RE NOW GETTING TO THE POINT WHERE WE HAVE THE NUMBERS WHERE IT'S WORTH TRYING TO DO", "iAHluJapkkE-00481-00287900-00288426": "A GWAS AND WE'LL SEE WHAT WE GET IN TERMS OF NEW DISCOVERY ON THE NEUROPATHY AND NEUTROPENIA", "iAHluJapkkE-00482-00288426-00289367": "SIDE FOR THIS STUDY WE ARE FINDING GENES THAT WE WOULD NOT EXPECT TO COME FORWARD.", "iAHluJapkkE-00483-00289367-00290005": "UNFORTUNATELY ONE OF THE GENES THAT LOOKS INTERESTING FOR NEUTROPENIA IS ASSOCIATED", "iAHluJapkkE-00484-00290005-00290286": "UNFORTUNATELY WITH THE SYNDROME CALLED MCLEOD SYNDROME.", "iAHluJapkkE-00485-00290286-00291008": "THAT HAS BEEN SOURCE OF TERRIBLE RIDICULE BY MY COLLEAGUES AS THEY MAKE FUN OF ME AND", "iAHluJapkkE-00486-00291008-00291514": "MY DISEASE THAT I DIDN'T EVEN KNOW ABOUT UNTIL NOW.", "iAHluJapkkE-00487-00291514-00292067": "SO, THIS SORT OF -- ONE AREA WE'RE TRYING TO DO DISCOVERY IN THE CONTEXT OF THIS SORT", "iAHluJapkkE-00488-00292067-00292659": "OF DATA SET. LAST PIECE IS REALLY ABOUT APPLYING THIS SORT", "iAHluJapkkE-00489-00292659-00292991": "OF WORK. TOO OFTEN WE FIND SOMETHING COOL IN THE LABORATORY,", "iAHluJapkkE-00490-00292991-00293438": "WE MAYBE DO A LOCAL ASSESSMENT OF WHETHER THIS BIOMARKER WILL WORK, WE EVEN DO LARGE", "iAHluJapkkE-00491-00293438-00293881": "VALIDATION STUDY. THE NEXT STEP IS NOTHING.", "iAHluJapkkE-00492-00293881-00294744": "OH, SURE WE PUBLISHED A STUDY IN THE JOURNAL WE GET NIH GRANT, WE GET FREE TRIP TO BETHESDA.", "iAHluJapkkE-00493-00294744-00295661": "BUT WHAT DO WE REALLY DO WITH THESE STUDIES? A COUPLE YEARS AGO MY MOTHER WAS ON THE INTERNET", "iAHluJapkkE-00494-00295661-00296219": "HOPEFULLY LOOKING FOR RECIPES OR SOMETHING. AND SHE CAME ACROSS PDFS OF SOME OF MY SCIENTIFIC", "iAHluJapkkE-00495-00296219-00296672": "PAPERS. SHE SENT THEM TO MY 97-YEAR-OLD GRANDMOTHER.", "iAHluJapkkE-00496-00296672-00297189": "MY GRANDMOTHER LIVES IN ASSISTED LIVING FACILITY WHERE NEW YEAR'S AGO THEY HAD BUNCH OF 14-YEAR-OLDS", "iAHluJapkkE-00497-00297189-00297860": "COME IN AND TEACH INHABITANTS HOW TO USE COMPUTERS. AND LEARN SOME OF THE LINGO, SHE'S NOT BLOGGING", "iAHluJapkkE-00498-00297860-00298326": "OR ANYTHING, DON'T GET ME WRONG BUT SHE DOCK SOME STUFF, PRETTY GOOD, BETTER THAN MY PARENTS.", "iAHluJapkkE-00499-00298326-00299273": "SHE SENT THEM TO MY -- PAPERS TO MY GRANDMOTHER AND I WAS TALKING TO HER, YOUR MOTHER SENT", "iAHluJapkkE-00500-00299273-00299569": "ME SOME OF YOUR MAGAZINES. I'M LIKE, OH, NO.", "iAHluJapkkE-00501-00299569-00300222": "TURNED OUT IT WAS SCIENCE STUFF IT WAS OKAY. WHAT DID YOU THINK, GRANDMA?", "iAHluJapkkE-00502-00300222-00300817": "WELL, MY GRANDMOTHER HAS THIRD GRADE EDUCATION, SHE'S ACTIVE LADY BUT NOT REAL SAVVY SCIENCE", "iAHluJapkkE-00503-00300817-00301222": "TYPE. WHAT DID YOU THINK, GRANDMA?", "iAHluJapkkE-00504-00301222-00302163": "SHE SAID, BEAUTIFUL FONT. I WAS SURPRISED SHE KNEW THE WORD FONT.", "iAHluJapkkE-00505-00302163-00302513": "IT DID NOTHING FOR HER. SHE WAS HAPPY TO SEE MY NAME ON THERE AND", "iAHluJapkkE-00506-00302513-00302973": "EVERYTHING BUT IT DID NOTHING FOR HER. ARE WE DOING THE KIND OF SCIENCE THAT IS GOING", "iAHluJapkkE-00507-00302973-00303423": "TO HELP HER GRANDSON GET PROMOTED AND DO LOTS OF COOL THINGS.", "iAHluJapkkE-00508-00303423-00303708": "OR DOING THE KIND OF SCIENCE THAT WILL HELP GRANDMA?", "iAHluJapkkE-00509-00303708-00304192": "TOO OFTEN WE'RE DOING STUFF THAT HAS NO HAND OFF.", "iAHluJapkkE-00510-00304192-00304726": "IF YOU LOOK AT INDUSTRIES, WHEN THERE'S A GROUP THAT IS DOING ENGINEERING FOR SOME PART", "iAHluJapkkE-00511-00304726-00305310": "OF A CAR THEY HAVE A PLAN FOR WHEN THEY'RE DONE, HANDING IT OFF TO THE NEXT PEOPLE WHO", "iAHluJapkkE-00512-00305310-00306055": "ARE GOING TO DO THE NEXT PART. IN SCIENCE, OFTEN OUR PLAN IS OSMOSIS.", "iAHluJapkkE-00513-00306055-00306516": "WE DO OUR SCIENCE, WE PUBLISH IT OUT THERE AND WE PRAY THAT SOMEONE WILL ACCIDENTALLY", "iAHluJapkkE-00514-00306516-00306907": "COME ACROSS IT AND THINK THAT, HEY, MAYBE THEY CAN USE IT IN THEIR AREA.", "iAHluJapkkE-00515-00306907-00307393": "WE HAVE NO PLAN AT ALL FOR HAND OFF OF WHERE IT'S GOING.", "iAHluJapkkE-00516-00307393-00307675": "WE NEED TO HAVE THAT. ONE OF THE THING WE'RE TRYING TO BUILD WITH", "iAHluJapkkE-00517-00307675-00308072": "MY INSTITUTE WAS PULLING TOGETHER ALL THESE PEOPLE TO HAVE A HAND OFF.", "iAHluJapkkE-00518-00308072-00308535": "I'M NOT SAYING WE'RE SUCCEEDING. BUT IT'S REALLY SOMETHING THAT WE NEED TO", "iAHluJapkkE-00519-00308535-00309039": "BE DOING AS A COUNTRY IS MAKING SURE THAT SOME OF THE PHENOMENAL BASIC SCIENCE, FUNDAMENTAL", "iAHluJapkkE-00520-00309039-00309718": "SCIENCE IS FAST TRACKED FORWARD. THE REASON IT'S NOT NOW IS MAINLY BECAUSE", "iAHluJapkkE-00521-00309718-00310160": "THE GROUPS AND VARIOUS SECTORS DON'T INTER-ACT, DON'T SEE EACH OTHER AND DON'T READ THE SAME", "iAHluJapkkE-00522-00310160-00310715": "JOURNALS SO IT'S NO SURPRISE THAT THERE'S AMAZING THINGS TUCKED AWAY THAT ARE NOT HELPING", "iAHluJapkkE-00523-00310715-00311345": "PEOPLE BECAUSE WE DIDN'T PLAN FOR THEM TO HELP SOMEONE.", "iAHluJapkkE-00524-00311345-00312238": "[ NOT AUDIBLE ] I THINK THAT -- CERTAINLY WE ARE HELPING PEOPLE.", "iAHluJapkkE-00525-00312238-00312794": "TOO OFTEN IT'S ON ACCIDENT. WHERE WE KNOW THIS PROBLEM.", "iAHluJapkkE-00526-00312794-00313176": "PART OF WHAT WE NEED TO DO, WE WORK VERY MUCH FORWARD.", "iAHluJapkkE-00527-00313176-00313482": "DO A BASIC DISCOVERY. BUILD ON THAT, MAKE IT MORE TRANSLATIONAL", "iAHluJapkkE-00528-00313482-00314206": "GO FORWARD. TOO OFTEN WE DON'T WORK BACKWARDS AT ALL.", "iAHluJapkkE-00529-00314206-00314456": "EVERYBODY IN THIS ROOM KNOWS THAT THERE'S BEEN PROGRESS MADE.", "iAHluJapkkE-00530-00314456-00314751": "CERTAINLY DON'T WANT TO YOU COME AWAY SAYING THAT WE'RE ALL BUNCH OF LOOSERS AND SHOULD", "iAHluJapkkE-00531-00314751-00315605": "GO DOWN TO BURGER KING AND APPLY FOR A JOB. THEY DO GIVE YOU FRIES WITH THAT.", "iAHluJapkkE-00532-00315605-00316240": "WE CAN DO BETTER BY PLANNING. THOSE OF YOU THAT ARE FOCUSING ON INDIVIDUAL", "iAHluJapkkE-00533-00316240-00316564": "AREA, I DON'T MEAN THAT THAT YOU SHOULD CHANGE BECOME SOMETHING ELSE.", "iAHluJapkkE-00534-00316564-00317043": "PLEASE, KEEP DOING WHAT YOU'RE DOING. BUT JUST REMEMBER THERE'S A HAND OFF AND HAVING", "iAHluJapkkE-00535-00317043-00317444": "THAT HAND OFF. WHEN YOU DROP A BATON IN RELAY RACE YOU'RE", "iAHluJapkkE-00536-00317444-00318113": "THE IDIOT YOU GET KICKED AND WE DROP THE BATON A LOT IN SCIENCE.", "iAHluJapkkE-00537-00318113-00318906": "BECAUSE WE DON'T PLAN FOR THE HAND OFF. IN THIS CONTEXT IS OFTEN NOT THE STEPS.", "iAHluJapkkE-00538-00318906-00319376": "THERE'S BEEN A LOT OF NEW ENGLAND JOURNAL PAPERS THAT HAVE HAD NOTHING DONE AFTER THAT", "iAHluJapkkE-00539-00319376-00319859": "BECAUSE THE INVESTIGATORS THOUGHT THIS THEY SUCCEEDED, THAT WAS THE GOAL.", "iAHluJapkkE-00540-00319859-00320260": "NOTHING DONE FURTHER. ONE EXAMPLE WHERE WE'RE TRYING TO TAKE THIS", "iAHluJapkkE-00541-00320260-00320919": "FORWARD IS IN THE BREAST CANCER DRUG TAMOXIFEN. MOST OF YOU ARE FAMILIAR WITH TAMOXIFEN, A", "iAHluJapkkE-00542-00320919-00321582": "DRUG THAT IS IN THE NEWS QUITE A LOT. BACK WHEN I TRAINED IT WAS SIMPLER TIME, TAMOXIFEN", "iAHluJapkkE-00543-00321582-00322732": "WHICH IS PARTIAL AN TAG GIST OF ESTROGEN WAS CONVERTED BY A NUMBER OF DIFFERENT ENZYMES.", "iAHluJapkkE-00544-00322732-00323101": "THAT WAS IT. THAT WAS HOW THE DRUG WORKED.", "iAHluJapkkE-00545-00323101-00324221": "COUPLE YEARS AGO ONCOLOGIST OVER AT GEORGETOWN UNIVERSITY AND HER COLLEAGUE HAD A PATIENT", "iAHluJapkkE-00546-00324221-00324735": "WITH BREAST CANCER WHO WAS TAKING TAMOXIFEN WAS GETTING THE HOT FLASHES, PERI MENOPAUSAL", "iAHluJapkkE-00547-00324735-00325181": "SYNDROME THAT YOU GET FROM THIS DRUG AND THAT'S EXPECTED AND NORMAL.", "iAHluJapkkE-00548-00325181-00325918": "BUT SHE ALSO HAD CLINICAL DEPRESSION. WAS TREATED WITH ONE OF THE SEROTONIN REUPTAKE", "iAHluJapkkE-00549-00325918-00326544": "INHIBITORS FOR HER DEPRESSION AND WITHIN A WEEK THE HOT FLASHES WENT AWAY.", "iAHluJapkkE-00550-00326544-00326943": "NOW IF IT HAD BEEN ME I WOULD HAVE BEEN JUMPING FOR JOY.", "iAHluJapkkE-00551-00326943-00327344": "ANYBODY WITH SCOTTISH BLOOD LOVES TWO FOR THE PRICE OF ONE.", "iAHluJapkkE-00552-00327344-00327839": "AND SO HOT FLASHES GO AWAY AND THE DEPRESSION WILL EVENTUALLY GO AWAY, TWO FOR THE PRICE", "iAHluJapkkE-00553-00327839-00328264": "OF ONE. GOT TO LOVE IT.", "iAHluJapkkE-00554-00328264-00329007": "WHAT SHE DID, WAIT A MINUTE, THAT'S WRONG. THE HOT FLASHES WENT AWAY SO QUICKLY, SOMETHING", "iAHluJapkkE-00555-00329007-00329398": "DIFFERENT GOING ON. SO PUSHED IT, ANALYZED IT FURTHER, WHAT SHE", "iAHluJapkkE-00556-00329398-00330231": "IDENTIFIED FA THERE'S A METABOLITE NOW CALLED ENDOXIFEN IS FORMED, FORMED ON THIS PATHWAY", "iAHluJapkkE-00557-00330231-00330899": "HERE WHERE THERE'S SOME REDUNDANCY ON THE FIRST STEP BUT THEN THE SECOND STEP.", "iAHluJapkkE-00558-00330899-00331482": "MOST OF THE ANTIDEPRESSANTS THAT WERE USED AT THE TIME ARE INHIBITORS OF THIS ENZYME.", "iAHluJapkkE-00559-00331482-00332104": "SO WHAT WAS HAPPENING WAS THAT THE ANTIDEPRESSANT, YEAH, MAKING THE HOT FLASHES GO AWAY BUT IT", "iAHluJapkkE-00560-00332104-00332409": "WAS MAKING THEM GO AWAY BECAUSE IT WAS NEUTRALIZING THE DRUG.", "iAHluJapkkE-00561-00332409-00332874": "THERE WAS NO ACTIVE METABOLITE BEING FORMED. YOUR HOT FLASHES CAN GO AWAY IF YOU DON'T", "iAHluJapkkE-00562-00332874-00333325": "TAKE THE DRUG. BUT YOU ALSO GET NO CLINICAL BENEFIT.", "iAHluJapkkE-00563-00333325-00334038": "SO THIS SORT OF DATA LED TO A DRAMATIC CHANGE IN WHICH ANTIDEPRESSANTS ARE USED IN BREAST", "iAHluJapkkE-00564-00334038-00334640": "CANCER PATIENTS. THERE ARE SOME THAT DO NOT INHIBIT THIS ENZYME", "iAHluJapkkE-00565-00334640-00335060": "THERE FOR HAVE BECOME THE DRUG OF CHOICE BECAUSE OF THAT DATA.", "iAHluJapkkE-00566-00335060-00335754": "AS MANY OF YOU KNOW, SOMEWHERE BETWEEN FIVE AND TEN PERCENT OF THE PEOPLE IN THIS ROOM", "iAHluJapkkE-00567-00335754-00336440": "ARE DEFICIENT FOR THIS ENZYME. YOUER HAVE DELETION OR NOT SYNONYMOUS SNP", "iAHluJapkkE-00568-00336440-00337010": "IN THIS GENE THAT CAUSES YOU TO NOT HAVE ANY FIX OF THIS GENE.", "iAHluJapkkE-00569-00337010-00337314": "YOU PROBABLY DON'T KNOW IT, IT DOESN'T CAUSE ANY OUTWARD AFFECT.", "iAHluJapkkE-00570-00337314-00337902": "THE ONES OF YOU THAT DO KNOW IT HAVE DONE PHENOTYPING ASSAY.", "iAHluJapkkE-00571-00337902-00338400": "THAT IS YOU WENT TO THE DENTIST, YOU HAD SOME DENTAL PAIN, HE GAVE YOU TYLENOL WITH CODEINE,", "iAHluJapkkE-00572-00338400-00338820": "YOU TOOK IT, IT DIDN'T HELP YOU AT ALL. YOU WENT BACK TO THE DENTIST HE SAID YOU WERE", "iAHluJapkkE-00573-00338820-00339210": "A WIMP. WELL, FIVE TO 10% OF YOU HAVE GENETIC REASON", "iAHluJapkkE-00574-00339210-00339634": "YOU ARE A WIMP. THE REST OF YOU ARE JUST WIMPS.", "iAHluJapkkE-00575-00339634-00340776": "YOU CANNOT ACTIVATE CODEINE TO THE ACTIVE METABOLITE AND TAMOXIFEN IN THIS CASE.", "iAHluJapkkE-00576-00340776-00341315": "SAME GENE FOR THAT. STUDIES HAVE BEEN DONE TO LOOK AT THE GENETIC", "iAHluJapkkE-00577-00341315-00341892": "VARIATION, WHAT IS SHOWN ON THIS AXIS CONCENTRATION OF ACTIVE METABOLITE.", "iAHluJapkkE-00578-00341892-00342472": "THERE'S A RELATIONSHIP BETWEEN WHETHER PERSON HAS TWO NORMAL COPIES ARE ONE NORMAL COPY", "iAHluJapkkE-00579-00342472-00342927": "OR NO NORMAL COPIES. FOUR METABOLIZERS OF THIS GENE.", "iAHluJapkkE-00580-00342927-00343539": "NOW THERE'S VARIABILITY WITHIN EACH OF THESE. THIS IS NOT THE ONLY CONTRIBUTOR TO THIS GENE'S", "iAHluJapkkE-00581-00343539-00343780": "FUNCTION. IT DOES INFLUENCE THIS GENE'S FUNCTION.", "iAHluJapkkE-00582-00343780-00344266": "WHAT IS SHOWN ON THE RIGHT HAND SIDE ARE PEOPLE WITH TWO NORMAL COPIES OR ONE NORMAL COPY", "iAHluJapkkE-00583-00344266-00344766": "BUT ON ONE OF THE INHIBITORS. IT'S REMINDING YOU THAT DRUG INTER-ARC CAN", "iAHluJapkkE-00584-00344766-00345767": "CAUSE SIMILAR AFFECT TO INTERMEDIATE OR HETEROZYGOUS VARIANT GENETIC CONDITION.", "iAHluJapkkE-00585-00345767-00346277": "EITHER DRUG INTER-ACTIONS OR GENETICS CAN BOTH INFLUENCE THE ACTIVE METABOLITE LEVEL", "iAHluJapkkE-00586-00346277-00346775": "IN THIS PARTICULAR CASE. THERE HAVE BEEN A LARGE NUMBER OF STUDIES", "iAHluJapkkE-00587-00346775-00347676": "THAT HAVE SHOWN ASSOCIATION BETWEEN GENOTYPE OF SIP 2D6 WITH PATIENTS ON TAMOXIFEN.", "iAHluJapkkE-00588-00347676-00348198": "ALSO BEEN THREE STUDIES, TWO FROM THE SAME GROUP IN SWEDEN ONE FROM ARKANSAS, THAT DID", "iAHluJapkkE-00589-00348198-00348843": "NOT FIND ASSOCIATION WITH TAMOXIFEN. YOU CAN TRY TO EXPLAIN BACK AND FORTH, THERE", "iAHluJapkkE-00590-00348843-00349144": "ARE DIFFERENCES IN HOW MANY VARIANTS THEY LOOKED AT.", "iAHluJapkkE-00591-00349144-00349870": "THERE ARE OVER 75 DIFFERENT VARIANCE OF GENES WANTED -- IF ONE WANTED TO BE COMPLETE.", "iAHluJapkkE-00592-00349870-00350479": "ALSO MOST OF THESE STUDIES HERE ARE LARGER AND HAVE PATIENTS THAT ARE JUST ON TAMOXIFEN", "iAHluJapkkE-00593-00350479-00350905": "WHERE AS SOME OF THE STUDIES HERE HAVE ADJUVANT CHEMOTHERAPY ALSO MICKED IN.", "iAHluJapkkE-00594-00350905-00351631": "WE'VE GOT TO THE POINT WHERE IT'S REALLY BEYOND PUBLICATION IN TERMS OF THE RELATIONSHIP.", "iAHluJapkkE-00595-00351631-00352086": "THESE ARE THE SORTS OF CURVES, THIS HAPPENS TO BE FROM ONE OF THE INITIAL STUDIES WHERE", "iAHluJapkkE-00596-00352086-00352682": "THE FOLKS WITH THE POOR METABOLIZER GENOTYPE HAVE POOR OUTCOME RELATIVELY SPEAKING, INTERMEDIATES", "iAHluJapkkE-00597-00352682-00353534": "HAVE INFERIOR OUTCOME BUT NOT QUOTE AS DRAMATICALLY DIFFERENT THEN EXTENSIVE METABOLIZERS HAVE", "iAHluJapkkE-00598-00353534-00353950": "THIS OUTCOME SHOWN HERE. WHAT THIS SHOWS YOU IS THAT THE GENOTYPE DOES", "iAHluJapkkE-00599-00353950-00354429": "INFLUENCE OUTCOMES AT SOME LEVEL. BUT EVEN IN THE GOOD GROUP, THE GREEN GROUP", "iAHluJapkkE-00600-00354429-00354946": "HERE THERE ARE STILL PATIENTS HAVING RECURRENCE OF BREAST CANCER, THAT CAN BE TUMOR BIOLOGY,", "iAHluJapkkE-00601-00354946-00355507": "SOME OTHER GERMLINE AFFECT. NEVER GOING TO BE ONE GENETIC SOLUTION TO", "iAHluJapkkE-00602-00355507-00356139": "A COMPLEX PROBLEM. SO ONE SHOULDN'T EXPECT THERE TO BE ONE GENE", "iAHluJapkkE-00603-00356139-00356413": "OR SUCH THAT IS GOING TO BE THE ANSWER TO THIS.", "iAHluJapkkE-00604-00356413-00356845": "IT'S A COMPLEX DISEASE, GOING TO HAVE A COMPLEX SOLUTION.", "iAHluJapkkE-00605-00356845-00357585": "WE DO SEE THIS SORT OF AFFECT. SOME OF THE INSURANCE COMPANIES HAVE NOW PICKED", "iAHluJapkkE-00606-00357585-00358081": "UP ON THIS. ARE STARTING TO OFFER TESTING, IN MANY CASES", "iAHluJapkkE-00607-00358081-00358666": "OFFERING TESTING FOR FREE. MEDCO HEALTH SOLUTIONS HAS WORKED WITH THE", "iAHluJapkkE-00608-00358666-00359183": "VARIOUS COMPANIES THAT THEY REPRESENT AND THEY'RE DRUG BENEFITS MANAGEMENT COMPANY.", "iAHluJapkkE-00609-00359183-00359946": "AND THEY NOW OFFER TESTING FOR TAMOXIFEN ALSO FOR WARFARIN FOR FREE.", "iAHluJapkkE-00610-00359946-00360647": "COMPLETELY TAKES OUT THE OCCASION -- THERE'S DISCUSSION IS IT WORTH THE COST OF THE TESTING", "iAHluJapkkE-00611-00360647-00361223": "BECAUSE THEY FACTORED IN TO THEIR RELATIONSHIP WITH IBM AND GENERAL MOTORS AND OTHER COMPANIES", "iAHluJapkkE-00612-00361223-00361718": "THAT THEY REPRESENT. EVERY PATIENT WHO GETS PRESCRIPTION FOR THOSE", "iAHluJapkkE-00613-00361718-00362351": "DRUGS IMMEDIATELY, LITERALLY IMMEDIATELY IN ELECTRONIC SENSE GETS OFFERED GENETIC TEST", "iAHluJapkkE-00614-00362351-00362863": "IF THEY'RE WILLING, PRESCRIBER OFFERS IT, THE TEST THEN THEY HAVE CLINICAL SUPPORT STAFF", "iAHluJapkkE-00615-00362863-00363193": "THAT HELPS THEM THROUGH THAT. YOU CAN SEE HOW THIS SORT OF THING CAN BE", "iAHluJapkkE-00616-00363193-00363645": "USED FOR EVIL. YOU IDENTIFY THE PEOPLE WHO ARE GOING TO NOT", "iAHluJapkkE-00617-00363645-00364079": "BENEFIT FROM TAMOXIFEN, YOU OFFER THEM AN ALTERNATE THERAPY.", "iAHluJapkkE-00618-00364079-00364677": "THAT SEEMS LIKE A NOBLE THING. TAMOXIFEN IS MUCH CHEAPER THAN ALTERNATE THERAPY.", "iAHluJapkkE-00619-00364677-00365227": "YOU CAN ALSO SEE SITUATION WHERE YOU GO, YOU ASSAY ALL THE PEOPLE ON THE ALTERNATE THERAPIES", "iAHluJapkkE-00620-00365227-00365907": "AND ONLY THE 5-7% THAT WILL NOT BENEFIT FROM TAMOXIFEN WILL LEAVE ON THAT.", "iAHluJapkkE-00621-00365907-00366441": "THE OTHER 95% YOU SAY, YOU CAN STAY ON THE THERAPY IF YOU WANT TO PAY FOR IT, BUT WE", "iAHluJapkkE-00622-00366441-00366942": "WILL ONLY PAY FOR YOUR TAMOXIFEN. IT'S NOT A BAD DRUG, SAVES MORE WOMEN'S LIVES", "iAHluJapkkE-00623-00366942-00367628": "THAN ANY OTHER THERAPY THAT'S OUT THERE. BUT THAT PATIENT AND CLINICIAN AUTONOMY WILL", "iAHluJapkkE-00624-00367628-00368025": "NOW BE PUT IN TO QUESTION BECAUSE OF THIS SORT OF RELATIONSHIP.", "iAHluJapkkE-00625-00368025-00368605": "THERE ARE ETHICAL ISSUES AND LEGAL AND SOCIAL ISSUES TO TRY TO WORK THROUGH IN TERMS OF", "iAHluJapkkE-00626-00368605-00369307": "HOW THIS IS IMPLEMENTED IN A WAY THAT IS GOOD FOR PATIENTS BUT NOT DRIVEN SOLELY BY COST", "iAHluJapkkE-00627-00369307-00369786": "SAVINGS AND ISSUES LIKE THAT. THE OTHER THING IS FOR THOSE PEOPLE WHO HAD", "iAHluJapkkE-00628-00369786-00370091": "ESPECIALLY BAD OUTCOME THEY NEED A DIFFERENT THERAPY.", "iAHluJapkkE-00629-00370091-00370594": "THESE FOLKS HERE WHAT DO WE DO? THE FEW OF YOU THAT ARE INTERESTED IN ON KONG", "iAHluJapkkE-00630-00370594-00371261": "MIGHT KNOW THAT TAMOXIFEN IS GIVEN AS 20 MILLIGRAM DOSE IN THIS COUNTRY BUT IS FDA APPROVED FROM", "iAHluJapkkE-00631-00371261-00371755": "10-40 MILLIGRAMS. THE MOST COMMON CALL WE WERE GETTING FROM", "iAHluJapkkE-00632-00371755-00372072": "COMMUNITY ONCOLOGISTS IS WHAT DO WE DO WITH THESE WOMEN?", "iAHluJapkkE-00633-00372072-00372642": "THIS IS LIKE 40% OF THE POPULATION. THEY KNOW WHAT TO DO HERE, DON'T HAVE CLUE", "iAHluJapkkE-00634-00372642-00373147": "WHAT TO DO WITH THESE 40%. WE INITIATED VERY SIMPLE STUDY WHERE WE TOOK", "iAHluJapkkE-00635-00373147-00373548": "PATIENTS THAT HAD BEEN ON TAMOXIFEN FOR AT LEAST FOUR MONTHS.", "iAHluJapkkE-00636-00373548-00374061": "WE MEASURED ACTIVE METABOLITE LEVELS WE SEE STATISTICAL DIFFERENCE, I DON'T HAVE THE PROPER", "iAHluJapkkE-00637-00374061-00374392": "VERSION YET BECAUSE OUR STATISTICIANS DON'T LIKE TO GENERATE PRETTY GRAPHICS.", "iAHluJapkkE-00638-00374392-00374903": "THIS IS A CARTOON VERSION OF IT. THE ACTIVE METABOLITE LEVELS ARE SIGNIFICANTLY", "iAHluJapkkE-00639-00374903-00375424": "DIFFERENT BETWEEN THOSE THAT ARE EXTENSIVE METABOLIZERS AND THOSE THAT ARE INTERMEDIATE.", "iAHluJapkkE-00640-00375424-00376099": "THESE FOLKS HAVE DIFFERENCES IN THEIR ACTIVE METABOLITE LEVELS IN OUR LOCAL STUDY.", "iAHluJapkkE-00641-00376099-00376575": "ADDITIONAL STUDY WAS 120 PATIENTS WE'RE NOW FINISHING UP 500 PATIENT STUDIES WITH THE", "iAHluJapkkE-00642-00376575-00376893": "SAME FINDING. WE WANTED TO ASK THE QUESTION IF WE LEAVE", "iAHluJapkkE-00643-00376893-00377569": "THESE PEOPLE, GREEN PEOPLE ON THEIR 20 MILLIGRAM DOSE ARE THEY STILL HAVING SIMILAR BLOOD LEVELS.", "iAHluJapkkE-00644-00377569-00377908": "THEY DO. THERE'S NO STATISTICAL DIFFERENCE BETWEEN", "iAHluJapkkE-00645-00377908-00378617": "THE START OF OUR -- THAT SHOULD BE FOUR MONTHS LATER.", "iAHluJapkkE-00646-00378617-00379302": "WE THEN TOOK THE PATIENTS WHO HAD LOW BLOOD LEVELS, GENETICALLY HETEROZYGOTES, WE DIDN'T", "iAHluJapkkE-00647-00379302-00379638": "MEASURE BLOOD LEVELS IN REALTIME. WE DOUBLED THEIR DOSE.", "iAHluJapkkE-00648-00379638-00380351": "IN THE 40 MILLIGRAM, NOTHING SEXY, NO KINASE INHIBITOR ANYTHING LIKE THAT WE JUST TOOK", "iAHluJapkkE-00649-00380351-00380652": "SAME OLD BORING DRUG AND WE GAVE THEM DOUBLE THE DOSE.", "iAHluJapkkE-00650-00380652-00381222": "STILL FDA APPROVED DOSE. WHAT WE FIND, ABLE TO NORMALIZE THE BLOOD", "iAHluJapkkE-00651-00381222-00381497": "LEVELS. THEY WENT FROM STATISTICAL DIFFERENCE HERE", "iAHluJapkkE-00652-00381497-00382027": "TO NO STATISTICAL DIFFERENCE HERE. THERE'S DRAMATIC INCREASE IN TERMS OF LOOKING", "iAHluJapkkE-00653-00382027-00382426": "WITHIN REACH PATIENT. BY DOING SOMETHING AS SIMPLE AND BORING AS", "iAHluJapkkE-00654-00382426-00383001": "DOUBLING THE DOSE, WE'RE NOW ABLE TO COMPLETELY NORMALIZE BLOOD LEVELS.", "iAHluJapkkE-00655-00383001-00384054": "AS I SHOWED YOU FROM THIS SLIDE HERE, EVEN WITH EQUIVALENT -- EXTENSIVE METABOLIZER GENOTYPE", "iAHluJapkkE-00656-00384054-00384480": "IN THIS CASE HIGHER BLOOD LEVELS YOU STILL HAVE PATIENTS WHO HAVE RECURRENCE.", "iAHluJapkkE-00657-00384480-00384963": "WAR NOT CURING EVERYONE. BUT WE BELIEVE THAT WE'VE CLOSED THIS GAP.", "iAHluJapkkE-00658-00384963-00385197": "AT LEAST AT THE PHARMACOKINETIC LEVEL WE'VE CLOSED THIS GAP.", "iAHluJapkkE-00659-00385197-00385577": "NOW HAVE TO DO THE FURTHER STUDIES IN TERMS MUCH OUTCOME.", "iAHluJapkkE-00660-00385577-00386100": "BEEN ABLE TO DEMONSTRATE BY DOING SOMETHING SIMPLE THAT CAN BE DONE AT ANY PRACTICE ACROSS", "iAHluJapkkE-00661-00386100-00387003": "THE U.S., USING ALREADY FDA APPROVED DOSE ONE CAN TAKE THIS BIOMARKER IN TERMS OF METABOLITES", "iAHluJapkkE-00662-00387003-00387698": "AND NORMALIZE IT FOR WHAT IS FUNCTIONALLY 95%.", "iAHluJapkkE-00663-00387698-00388176": "THIS SORT OF STORY NEEDS NOW TO GO ON TO THE SURVIVAL TYPE DATA.", "iAHluJapkkE-00664-00388176-00388782": "BUT USING SHORT TERM BIOMARKER ABLE TO SHOW THE GENETICS CAN CAUSE THIS SORT OF AFFECT.", "iAHluJapkkE-00665-00388782-00389438": "THE IDEAL GET TO POINT WHERE WE CAN HAVE TOXICITY, EVALUATION, DISEASE EVALUATION, SUPPORTIVE", "iAHluJapkkE-00666-00389438-00389866": "CARE OF ALL DONE PRIOR TO EVER PRESCRIBING A DRUG.", "iAHluJapkkE-00667-00389866-00390563": "THAT DAY MAY COME AT SOME POINT IN TIME. BUT IT'S STILL A WAYS OFF, ESPECIALLY WAYS", "iAHluJapkkE-00668-00390563-00391214": "OFF IF WE LOOK FROM A GLOBAL STANDPOINT. WE LOOK AROUND THE WORLD THERE'S LOT OF COUNTRIES", "iAHluJapkkE-00669-00391214-00392057": "THAT HAVE INTACT HEALTH SYSTEM BUT DON'T HAVE THE ABILITY TO DO GENOTYPING IN EVERY PATIENT.", "iAHluJapkkE-00670-00392057-00392581": "LAST FEW MINUTES I'M GOING TO MENTION BRIEFLY SOME OF THE GLOBAL HEALTH EFFORTS WE'VE TRIED", "iAHluJapkkE-00671-00392581-00392896": "TO MAKE THE GENOME USEFUL TO THE DEVELOPING WORLD.", "iAHluJapkkE-00672-00392896-00393876": "WITH THE HUMAN GENOME PROMISE THERE'S LOTS OF THINGS SUPPOSED TO DO IN TERMS MUCH BETTER", "iAHluJapkkE-00673-00393876-00394421": "DIAGNOSIS AND BETTER SELECTION OF THERAPY AND GENOME TYPE GUIDED THERAPY NOW STARTING", "iAHluJapkkE-00674-00394421-00394815": "TO HAPPEN IN RICH COUNTRIES, MAINLY IN THE WEST.", "iAHluJapkkE-00675-00394815-00395352": "WHAT ABOUT THE REST OF THE WORLD? SEEMS TO BE ALWAYS 30 YEARS BEHIND.", "iAHluJapkkE-00676-00395352-00395830": "THAT GAP NEVER CLOSES. WE TRIED TO COME UP WITH A WAY TO MAKE THE", "iAHluJapkkE-00677-00395830-00396499": "GENOME USEFUL NOW TO THE REST OF THE WORLD. THE GENOME WHEN YOU TALK TO THE FOLKS IN MANY", "iAHluJapkkE-00678-00396499-00396910": "DEVELOPING COUNTRIES THE GENOME IS COMPLETELY A WESTERN TOY.", "iAHluJapkkE-00679-00396910-00398049": "HUMAN GENOME PROJECT HAS BEEN JUST AS USELESS TO THEM AS YOUR FAVORITE DISNEY PRINCESS.", "iAHluJapkkE-00680-00398049-00398546": "IT'S REALLY SOMETHING THAT IS MEANINGLESS. THEY KNOW IT WILL BE 30 YEARS BEFORE THEY", "iAHluJapkkE-00681-00398546-00398919": "CAN USE IT. WE'VE TRIED TO MOVE FORWARD SAY IF YOU CAN'T", "iAHluJapkkE-00682-00398919-00399368": "DO INDIVIDUAL PATIENT GENOTYPING CAN WE DO SOMETHING THAT'S USEFUL.", "iAHluJapkkE-00683-00399368-00400051": "THE BEST OPTION IS THAT EACH PERSON UNDERSTANDS THEIR MAKE UP, GENETICALLY AND OTHERWISE AND", "iAHluJapkkE-00684-00400051-00400625": "THEN MAKES DECISIONS ON THERAPY BASED ON THAT. THAT'S THE IDEAL.", "iAHluJapkkE-00685-00400625-00401388": "THE WORST SITUATION THAT YOU INFER DATA FROM ONE POPULATION ON TO THE REST OF THE WORLD.", "iAHluJapkkE-00686-00401388-00401939": "THAT'S WHAT WE DO NOW. MOST OF THE WORLD USES EITHER THE EMEA, EUROPEAN", "iAHluJapkkE-00687-00401939-00402558": "HEAD CANE AGENCY OR FDA SAFETY DATA FOR STARTING POINT FOR THEIR DRUG.", "iAHluJapkkE-00688-00402558-00403099": "EITHER CAN'T AFFORD OR DON'T WANT TO DO SEPARATE STUDIES.", "iAHluJapkkE-00689-00403099-00404046": "WHAT HAPPENS IS THAT MOST OF THE INITIAL STUDIES IN THE U.S. AND MOST STUDIES WITH NEW DRUGS", "iAHluJapkkE-00690-00404046-00405100": "ARE CONDUCTING -- EASTERN EUROPEAN STUDIES THAT ARE BEING DONE NOW STILL REPRESENT VERY", "iAHluJapkkE-00691-00405100-00405704": "WHITE POPULATION. PHASE ONE STUDIES IS 18-40-YEAR-OLD MIGHT", "iAHluJapkkE-00692-00405704-00406385": "WHITE MALE. -- THEY ARE WHITE.", "iAHluJapkkE-00693-00406385-00407223": "THEY MAY NOW BE WHITES FROM UKRAINE INSTEAD OF WHITES FROM AUSTRALIA OR NORTH CAROLINA.", "iAHluJapkkE-00694-00407223-00407613": "BUT THEY'RE STILL NOT VERY REPRESENTATIVE OF THE WORLD POPULATION.", "iAHluJapkkE-00695-00407613-00408108": "SO NO SURPRISE THAT WHEN DRUGS GET TO THE REST OF THE WORLD THEY FIND DIFFERENCES IN", "iAHluJapkkE-00696-00408108-00408604": "TERMS OF TOXICITY PROFILE, BOAST INCIDENCE AND TYPES OF TOXICITY, DOSING THAT IS NEEDED", "iAHluJapkkE-00697-00408604-00409117": "AS THEY GO FORWARD. INTERMEDIATE STEP TO TRY TO UNDERSTAND THE", "iAHluJapkkE-00698-00409117-00409700": "GENETIC RISKS OF TOXICITY IN INDIVIDUAL POPULATIONS WITHIN A COUNTRY.", "iAHluJapkkE-00699-00409700-00410018": "VERY MUCH GOING ON THE VOLTAIRE, THE BEST IS THE ENEMY OF GOOD.", "iAHluJapkkE-00700-00410018-00410479": "BEST IS ULTIMATE GOAL. PERFECTION IS ULTIMATE GOAL.", "iAHluJapkkE-00701-00410479-00410971": "IN THIS CASE IT'S BEING ABLE TO LOOK AT THE INDIVIDUAL PATIENT IN EVERY PERSON THAT NEEDS", "iAHluJapkkE-00702-00410971-00411533": "THERAPY. IN THE MEANTIME CAN STILL DO GOOD.", "iAHluJapkkE-00703-00411533-00411863": "WE WAIT FOR PERFECTION, THERE FOR DON'T DO GOOD.", "iAHluJapkkE-00704-00411863-00412338": "THAT'S NOT VERY GOOD ENGLISH, YOU KNOW WHAT I MEAN.", "iAHluJapkkE-00705-00412338-00412735": "CAN WE DO SOMETHING NOW WHILE WE'RE WAITING TO DO THE IDEAL.", "iAHluJapkkE-00706-00412735-00413379": "WE'VE TAKEN THE W.H.O. MEDICINE LIST, I'VE DONE A LOT OF WORK ON IDENTIFYING OF THESE", "iAHluJapkkE-00707-00413379-00414088": "206 SAYS STEM I CAN DRUGS WHICH GENES INFLUENCE THE METABOLISM, TRANSPORT OR TARGETS FOR THESE", "iAHluJapkkE-00708-00414088-00414510": "DRUGS AND LOOKING AT THE VARIANTS THAT INFLUENCE THESE DRUGS.", "iAHluJapkkE-00709-00414510-00415088": "WE DON'T MEAN VARIANTS THAT ARE NON-SYNONYMOUS. WE DON'T MEAN VARIANTS THAT CAUSE CHANGE IN", "iAHluJapkkE-00710-00415088-00415488": "BLOOD LEVEL. VARIANTS THAT HAVE BEEN SHOWN IN AT LEAST", "iAHluJapkkE-00711-00415488-00416163": "TWO POPULATIONS TO CAUSE A CHANGE, AT LEAST DOUBLING OF THE RISK OF TOXICITY OR ALTERED", "iAHluJapkkE-00712-00416163-00416915": "EFFICACY OF REAL PEOPLE. RIGHT NOW IN THE U.S. YOU HAVE TO HAVE PRETTY", "iAHluJapkkE-00713-00416915-00417251": "AMAZING STUDIES. WE'RE ALWAYS TALKING ABOUT PROSPECTIVE RANDOMIZED", "iAHluJapkkE-00714-00417251-00417758": "TRIALS TO CHANGE WHICH THERAPY YOU MIGHT GIVE AN INDIVIDUAL PERSON.", "iAHluJapkkE-00715-00417758-00418335": "IF YOU'RE BUYING DOCTORS DRUGS FOR A NATIONAL FORMULARY, THE NATIONAL DRUG MENU FOR A COUNTRY,", "iAHluJapkkE-00716-00418335-00418906": "IF YOU HAVE TWO EQUAL THERAPIES, TWO DRUGS THAT ARE EQUALLY EFFECTIVE, HAVE CALL COST,", "iAHluJapkkE-00717-00418906-00419543": "EQUAL ACCESSIBILITY ALL YOU NEED IS FEATHER OF DATA TO SHIFT ONE VERSUS THE OTHER.", "iAHluJapkkE-00718-00419543-00420005": "YOU DON'T NEED TO HAVE HUGE AMOUNT OF DATA. BECAUSE YOU HAVE TO CHOOSE ONE OF THESE.", "iAHluJapkkE-00719-00420005-00420500": "IN THIS COUNTRY IF YOU DON'T LIKE THE DRUG THAT IS ON YOUR FORMULARY OR INSURANCE COMPANY", "iAHluJapkkE-00720-00420500-00420893": "YOU FILL OUT A LITTLE FORM, GET IT SIGNED BY YOUR DOCTOR USUALLY YOU CAN GET A WAIVER", "iAHluJapkkE-00721-00420893-00421426": "SO YOU CAN USE SOME OTHER THERAPY. IN MOST OF THE WORLD THEY HAVE ONE SET OF", "iAHluJapkkE-00722-00421426-00421992": "DRUGS FOR THE TREATMENT OF MOST DISEASES AND IF YOU WANT ANYTHING ELSE, YOU CAN GO FLY", "iAHluJapkkE-00723-00421992-00422267": "TO SWITZERLAND. BECAUSE THERE ARE NO OTHER CHOICES.", "iAHluJapkkE-00724-00422267-00422767": "IT'S A HIGH STAKES DEAL ABOUT WHICH DRUGS ARE AVAILABLE BECAUSE THEY CAN ONLY AFFORD", "iAHluJapkkE-00725-00422767-00423289": "ONE OR TWO OPTIONS FOR EACH COMMON DISEASE. SO BY USING THIS DATA, ONE CAN THEN TRY TO", "iAHluJapkkE-00726-00423289-00423975": "MAKE THESE CHOICES. AS AN EXAMPLE THE -- ON THIS LIST FOR PHARMACOGENETIC", "iAHluJapkkE-00727-00423975-00424581": "THESE DRUGS ARE USED FOR RHEUMATOID ARTHRITIS, INFLAMMATORY BO WORK HE CANL DISEASE, ALSO", "iAHluJapkkE-00728-00424581-00425126": "TREATMENT OF CHILDHOOD LEUKEMIA. SO IF YOU LOOK AT THE GENOME THERE ARE VARIANTS", "iAHluJapkkE-00729-00425126-00425518": "IN THE GENE THAT ARE ASSOCIATED WITH SEVERE NEUTROPENIA.", "iAHluJapkkE-00730-00425518-00426105": "IN SOME CASES FATAL NEUTROPENIA. THESE ARE THE MAIN VARIANTS THAT HAVE BEEN", "iAHluJapkkE-00731-00426105-00426804": "SHOWN ACROSS THE WORLD TO BE IMPORTANT. DEPENDING ON WHAT GENOTYPE STATUS, THERE ARE", "iAHluJapkkE-00732-00426804-00427176": "DIFFERENT DOSING REQUIREMENTS THAT ARE ALREADY WELL-KNOWN.", "iAHluJapkkE-00733-00427176-00427639": "ONE CAN TAKE THAT DATA AND CERTAINLY HERE IN THIS COUNTRY WE USE THAT DATA TO TRY TO", "iAHluJapkkE-00734-00427639-00428097": "IDENTIFY RISK AND TO ADJUST THE DOSE OF THE DRUG.", "iAHluJapkkE-00735-00428097-00428521": "WE'VE CREATED THESE WORLD MAPS, SO WE WALK YOU THROUGH THEM VERY BRIEFLY, IF YOU SEE", "iAHluJapkkE-00736-00428521-00428931": "GRAY THERE WAS NO DATA. IF YOU SEE GREEN IT MEANS DATA IS VERY SIMILAR", "iAHluJapkkE-00737-00428931-00429410": "TO THE U.S. WHITE POPULATION. I PICKED U.S. WHITE POPULATION NOT BECAUSE", "iAHluJapkkE-00738-00429410-00429871": "I'M A U.S. WHITE BUT BECAUSE THAT'S WHERE DRUGS ARE DEVELOPED WE DON'T HAVE TO LIKE", "iAHluJapkkE-00739-00429871-00430511": "IT BUT THAT IS THE CURRENT STATE OF AFFAIRS. LIGHT BLUE MEANS RISK IS ONE HALF OR LESS.", "iAHluJapkkE-00740-00430511-00431063": "YELLOW MEANS THE RISK IS DOUBLE OR MORE. CONDITIONALLY LIKE GHANA, WHICH WE STARTED", "iAHluJapkkE-00741-00431063-00431896": "WORKING IN BACK IN 1994 LOOK AT THE FREQUENCY OF THE VARIANTS FOR THIS GENE, THEY HAVE 10%", "iAHluJapkkE-00742-00431896-00432684": "OF THE MICROSOFT PEW LAKE HAVE HIGH RISK VARIANT FOR SEVERE TOXICITY FROM THESE DRUGS.", "iAHluJapkkE-00743-00432684-00433385": "THAT'S BEEN BACKED UP BY A HIGH INCIDENCE OF TOXICITY IN THE STUDIES.", "iAHluJapkkE-00744-00433385-00434072": "ONE CAN GO IN LOOK AT THE DATA, LOOKING ACROSS THE MOST COMMON TRIBES WITHIN GHANA, YOU CAN", "iAHluJapkkE-00745-00434072-00434835": "SEE THEY'RE ALL PRETTY MUCH THE SAME, REALLY NO STATISTICAL DIFFERENCE AMONG THESE PARTICULAR", "iAHluJapkkE-00746-00434835-00435443": "GROUPS WITHIN THE COUNTRY. WHAT'S SHOWN HERE ON THIS SLIDE IS THE POPULATION", "iAHluJapkkE-00747-00435443-00435831": "FROM THE HAPMAP. IF YOU ARE GEOGRAPHICALLY INCLINED, THERE", "iAHluJapkkE-00748-00435831-00436772": "IS GHANA AND TOGO AND NIGERIA IN WEST AFRICA. BOTH FORMER ENGLISH COLONIES, LOT OF SIMILARITIES,", "iAHluJapkkE-00749-00436772-00437497": "GHANA HAS MUCH BETTER SOCCER TEAM IF ANY OF YOU FROM NIGERIA, I'M SORRY BUT GHANA, THE", "iAHluJapkkE-00750-00437497-00438077": "BLACK STARS RULE. IF YOU LOOK YOU EXPECT THEY WOULD BE THE SAME.", "iAHluJapkkE-00751-00438077-00438881": "AS A MATTER OF FACT HAVE BEEN PITCHED -- WELL FOR THIS PARTICULAR CLINICALLY ACTIONABLE", "iAHluJapkkE-00752-00438881-00439768": "GENOTYPE THE FREQUENCY IN THE ERUBAN POPULATION ONE HALF THAT SCREEN IN NEARBY GHANA.", "iAHluJapkkE-00753-00439768-00440485": "AND THEY ARE IDENTICAL IN FREQUENCY TO THE U.S. AND U.K. CAUCASIAN.", "iAHluJapkkE-00754-00440485-00441005": "WHEN WE TALK ABOUT THESE POPULATION DIFFERENCES WONDERING WHY WE'D NEED TO LOOK AT EACH COUNTRY,", "iAHluJapkkE-00755-00441005-00441569": "EACH GROUP WITHIN THE COUNTRY THIS TYPE OF DATA WHERE YOU ARE TALKING ABOUT CLINICALLY", "iAHluJapkkE-00756-00441569-00442292": "ACTIONABLE VARIANT YOU LOOK AT THAT LEVEL OF RESOLUTION THERE ARE DRAMATIC DIFFERENCES", "iAHluJapkkE-00757-00442292-00442572": "BETWEEN COUNTRIES THAT YOU WOULD EXPECT TO BE IDENTICAL.", "iAHluJapkkE-00758-00442572-00443159": "SO THIS SORT OF INFORMATION WE'RE USING AS WE MOVE FORWARD.", "iAHluJapkkE-00759-00443159-00443710": "WE HAVE DATA ON THE SURVEILLANCE OF PATIENTS WHERE YOU GO IN, HEIGHTENED RISK YOU'D MONITOR", "iAHluJapkkE-00760-00443710-00444251": "PATIENTS MORE CAREFULLY. SOMETHING LIKE -- IF YOU HAVE HEIGHTENED RISK", "iAHluJapkkE-00761-00444251-00444751": "OF LIVER TOXICITY BASED ON GENETICS YOU'RE NOT GOING TO STOP USING THIS, IT'S TOO IMPORTANT", "iAHluJapkkE-00762-00444751-00445278": "FOR TUBERCULOSIS, YOU'D MONITOR THE PATIENTS MORE OFTEN WE HAVE SEVERAL PROGRAMS WHERE", "iAHluJapkkE-00763-00445278-00445738": "WE MONITOR PATIENTS EVERY SIX MONTHS -- SORRY EVERY THREE MONTHS INSTEAD OF SIX MONTHS USING", "iAHluJapkkE-00764-00445738-00446221": "CHEAP LITTLE DIP STICK TYPE EVALUATION THAT ARE AFFORDABLE IN THOSE COUNTRIES.", "iAHluJapkkE-00765-00446221-00446772": "YOU ALSO CAN PRIORITIZE AVAILABLE THERAPIES SO IF YOU LOOK AT MALARIA, THE W.H.O. HAS", "iAHluJapkkE-00766-00446772-00447246": "FOUR DIFFERENT DRUG SETS THAT THEY PROPOSE AS BEING ANY OF THESE FOUR ARE THE RIGHT ONES", "iAHluJapkkE-00767-00447246-00447643": "FOR MALARIA, IN MANY COUNTRIES THESE TWO HAVE TOO MUCH RESISTANCE.", "iAHluJapkkE-00768-00447643-00448082": "ARE NOT USED. YOU REALLY STUCK WITH THESE TWO ON THE OUTSIDE.", "iAHluJapkkE-00769-00448082-00448713": "IF YOU LOOK AT ONE OF THESE PARTICULAR DRUGS ITS METABOLIZED BY P450 TO THIS METABOLITE.", "iAHluJapkkE-00770-00448713-00449235": "EITHER THE PARENT OR METABOLITE ARE EQUALLY EFFECTIVE.", "iAHluJapkkE-00771-00449235-00449844": "METABOLISM DOESN'T INFLUENCE EFFICACY AT ALL. IF YOU HAVE GENETIC VARIANT IN THE METABOLISM", "iAHluJapkkE-00772-00449844-00450489": "YOU HAVE MORE ACTIVE DRUG -- MORE PARENT DRUG THAT SHIFTS DOWN TO FORM THE TOXIC METABOLITE.", "iAHluJapkkE-00773-00450489-00451060": "GENETIC VARIATION INFLUENCES AMOUNT OF TOXICITY THAT IS SEEN IN THESE DIFFERENT POPULATIONS.", "iAHluJapkkE-00774-00451060-00452898": "THIS WAS INITIALLY FOUND IN ZANZIBAR OFF OF THE COAST OF TANZANIA USING --", "iAHluJapkkE-00775-00452898-00453303": "IF YOU HAVE 2% AT HEIGHTENED RISK YOU DON'T EVEN CARE.", "iAHluJapkkE-00776-00453303-00453888": "YOU BLOW IT OFF. IT'S SO RARE, WHO CARES.", "iAHluJapkkE-00777-00453888-00454659": "WELL, IF YOU THEN PUT IN THE BURDEN OF DISEASE, 2% OF THE ZANZIBAR POPULATION WILL GET SEVERE", "iAHluJapkkE-00778-00454659-00455046": "TOXICITY FROM THIS DRUG. THAT EQUALS 30,000 PEOPLE PER YEAR ON ONE", "iAHluJapkkE-00779-00455046-00455595": "TINY ISLAND. THE BURDEN OF DISEASE COMBINED WITH THE LEGAL", "iAHluJapkkE-00780-00455595-00456327": "OF INCIDENCE SUDDENLY HEIGHTENS -- IF I CAME TO YOU SAID, YOU COULD IDENTIFY 30,000 PEOPLE", "iAHluJapkkE-00781-00456327-00456889": "WHO ARE GOING TO GET SEVERE LIVER TOXICITY FROM THIS ANTI-MALARIA DRUG YOU'D CARE, BRING", "iAHluJapkkE-00782-00456889-00457277": "IN THE BURDEN OF DISEASE ALONG WITH THE GENETIC VARIANCE IS IMPORTANT.", "iAHluJapkkE-00783-00457277-00457787": "YOU GO TO BOW LIVE WHY ALMOST DOUBLE THE FREQUENCY OF THIS VARIANT BUT VERY LITTLE MALARIA ONLY", "iAHluJapkkE-00784-00457787-00458844": "64. BRINGING THIS SORT OF DATA ALLOWS US TO WORK", "iAHluJapkkE-00785-00458844-00459405": "WITH THE MINISTRIES OF HEALTH, HELP GUIDE ON WHICH THERAPY ONE CAN LOOK AT.", "iAHluJapkkE-00786-00459405-00460329": "WE DON'T BRINK AT ALL WHEN WE LOOK AT --  BUT WE ALSO HAVE TO LOOK AT THE PATIENT.", "iAHluJapkkE-00787-00460329-00460788": "THEIR GERM LINES, HOST GENOME IN TERMS OF MAKING THESE DECISIONS THAT'S BEEN COMPLETELY", "iAHluJapkkE-00788-00460788-00461523": "NEGLECTED WITH THE CURRENT GLOBAL HEALTH PLAN. HOPEFULLY WE'LL BE ABLE TO PUSH THIS FORWARD.", "iAHluJapkkE-00789-00461523-00462031": "SO IN CONCLUSION, WE ARE GETTING PRETTY GOOD AT DISCOVERING THINGS.", "iAHluJapkkE-00790-00462031-00462538": "WE DISCOVER SOMETHING WE LOOK AT THE OUTCOME WE FEEL GOOD ABOUT IT.", "iAHluJapkkE-00791-00462538-00463048": "EXCEPT THERE'S LOT MORE THAT NODES TO BE DONE BEFORE THINGS CAN BECOME ROUTINE PRACTICE.", "iAHluJapkkE-00792-00463048-00463482": "SO AS YOU'RE GOING FORWARD, I WOULD ENCOURAGE TO YOU START THINKING ABOUT WHO ARE THE OTHER", "iAHluJapkkE-00793-00463482-00463989": "PEOPLE THAT NEED TO GET INVOLVED. YOU DO NOT WANT TO BECOME A CLINICAL PATHOLOGIST.", "iAHluJapkkE-00794-00463989-00464562": "OR MEDICAL INFORMAT CYST OR HEALTH SYSTEMS INTEGRATOR, YOU CERTAINLY DON'T WANT TO BE", "iAHluJapkkE-00795-00464562-00465414": "A HEALTH ECONOMIST BUT THEY MAY BE THE KEY TO YOUR SCIENCE HELPING SOMEONE.", "iAHluJapkkE-00796-00465414-00465833": "SO PLANNING THE TYPES OF TEAMS THAT CAN REALLY DRIVE THIS FORWARD IN TO ROUTINE PRACTICE", "iAHluJapkkE-00797-00465833-00466129": "ARE KEY. UNTIL WE DO THAT WE'RE GOING TO RECREATE GREAT", "iAHluJapkkE-00798-00466129-00466660": "SCIENCE THAT WILL EVENTUALLY HELP SOMEONE GUT THOUGHT AT THE PACE THAT IT COULD.", "iAHluJapkkE-00799-00466660-00467062": "PHARMACOGENETIC RESEARCH NETWORK GAVE US A BUNCH OF CASH TO DO THE STUDIES, WE THANK", "iAHluJapkkE-00800-00467062-00467435": "THEM FOR IT. MY LOCAL INSTITUTE PULLS TOGETHER THE VARIOUS", "iAHluJapkkE-00801-00467435-00467817": "PEOPLE THAT HELPS US TO DO THIS WORK I'LL STOP RIGHT THERE.", "iAHluJapkkE-00802-00467817-00469088": "THANK YOU VERY MUCH. [APPLAUSE]", "iAHluJapkkE-00803-00469088-00471618": "[ NOT AUDIBLE ] >> HERE IS A QUESTION.", "iAHluJapkkE-00804-00471618-00472763": "IT'S A NICE IDEA, THE GLOBAL HEALTH ISSUES, IT IS CLEAR THIS IS A VERY LARGE EFFORT AS", "iAHluJapkkE-00805-00472763-00473150": "YOU POINTED OUT WE'RE JUST BEGINNING IN THIS EFFORT.", "iAHluJapkkE-00806-00473150-00474042": "WHAT IS YOUR ESTIMATION, HOW MANY MORE YEARS, 50, 100, 200 YEARS WILL WE TAKE WHEN WE REACH", "iAHluJapkkE-00807-00474042-00474514": "LEVEL OF SOPHISTICATION WHICH YOU WANT TO ACHIEVE?", "iAHluJapkkE-00808-00474514-00475169": ">> HARD TO PREDICT BECAUSE CHANGES THAT HAPPENED OVER THE LAST YEAR HAVE BEEN MUCH FASTER THAN", "iAHluJapkkE-00809-00475169-00475761": "I WOULD HAVE ANTICIPATED. WITH COMPANIES THAT ARE DEVELOPING NEW DRUGS", "iAHluJapkkE-00810-00475761-00476369": "NOW HAVING LARGE DATA SETS, ACTUALLY DOING SOMETHING WITH THOSE DATA SETS IT'S REALLY", "iAHluJapkkE-00811-00476369-00476892": "CHANGED THE GAME. WITH THE NIH NOW HAVING GENETICS BLOOD SAMPLING", "iAHluJapkkE-00812-00476892-00477585": "AS PART OF THEIR CLINICAL TRIALS AND ENFORCING IT IN MANY CASES IT'S CHANGING THE GAME.", "iAHluJapkkE-00813-00477585-00478083": "NOW THAT WE HAVE DATA SETS FOR MANY OF THE LARGE -- THERAPEUTIC AREAS THAT ARE LARGE", "iAHluJapkkE-00814-00478083-00478796": "ENOUGH TO ACTUALLY DRAW CONCLUSIONS I NOW THINK THAT WE'RE LOOKING AT PROBABLY 15 YEAR", "iAHluJapkkE-00815-00478796-00479227": "HORIZON BEFORE HALF OF THE DRUGS THAT ARE PRESCRIBED WILL HAVE CLEAR DATA.", "iAHluJapkkE-00816-00479227-00479767": "I DON'T THINK WE'LL GET TO THE DATA WHERE ALL DRUGS WILL HAVE THIS DATA PARTLY BECAUSE", "iAHluJapkkE-00817-00479767-00480446": "THAT ARE SO SAFE THEY DON'T NEED TO BE INDIVIDUALIZED. ONES THAT ARE BEING FOCUSED ON NOW ARE EITHER", "iAHluJapkkE-00818-00480446-00481257": "UNSAFE IN SUBSTANTIAL POPULATION, ARE SUPER EXPENSIVE OR BOTH.", "iAHluJapkkE-00819-00481257-00481834": "WE'RE SEEING THAT SORT OF EMPHASIS. THERAPEUTIC AREAS THAT I NEVER THOUGHT WOULD", "iAHluJapkkE-00820-00481834-00482519": "HAVE MARKERS NOW HAVE SOME REALLY NICE DATA. INTERFERON FOR HEPATITIS, I WOULD HAVE BET", "iAHluJapkkE-00821-00482519-00483030": "YOU GOOD MONEY THAT WE WOULD NEVER HAVE MARKER FOR WHO IS -- FOR PREDICTING WHO IS GOING", "iAHluJapkkE-00822-00483030-00483946": "TO RESPOND TO INTERFERON, WE DO. THE DATA THAT JUST CAME OUT IN \"SCIENCE\" REALLY", "iAHluJapkkE-00823-00483946-00484384": "DRUGS THAT I THOUGHT WERE SO FAR DOWN THE LIST WE'D NEVER HAVE ANY DATA, HERE WE GO.", "iAHluJapkkE-00824-00484384-00484971": "I HAVE BECOME CAUTIOUSLY OP TOE OPTIMISTIC THAT WE'RE STARTING TO SEE TRACTION WITH DRUGS", "iAHluJapkkE-00825-00484971-00485260": "THAT WE CARE ABOUT. >> GOOD TO HEAR THAT.", "iAHluJapkkE-00826-00485260-00485634": "THANK YOU. ANOTHER QUESTION.", "iAHluJapkkE-00827-00485634-00486482": "IN THINKING ABOUT THE CHEMOTHERAPY AND NEUROTOX 'TIS TEASE, ANOTHER WAY WOULD BE -- IF PEOPLE", "iAHluJapkkE-00828-00486482-00487534": "LOOK AT DEMYELINATION OR ANYTHING LIKE THAT, ON THE NERVES, ON THE CELLS HAS ANYBODY LOOKED", "iAHluJapkkE-00829-00487534-00487844": "AT THAT LEVEL? >> THEY HAVE.", "iAHluJapkkE-00830-00487844-00489007": "MAINLY IN RATS TO DATE. AND SEEMS TO BE MAJOR SITE FOR TOXICITY.", "iAHluJapkkE-00831-00489007-00489560": "WE HAVE FOLLOW-UP STUDY IN COLLABORATIVE WITH ALL THESE MOUSE STRAINS TO TRY TO LOOK AT", "iAHluJapkkE-00832-00489560-00490657": "THAT, THE POOR TECHNICIAN OUT MUCH EACH MOUSE. WE'LL TRY TO LOOK SEE ARE THIS GENETIC PREDICTORS", "iAHluJapkkE-00833-00490657-00490982": "WHO HAVE IS GETTING TOXICITY AT THAT LOCAL SITE.", "iAHluJapkkE-00834-00490982-00491257": "YOU'RE RIGHT. SO MANY DIFFERENT FACTORS.", "iAHluJapkkE-00835-00491257-00491746": "IT APPEARS THAT'S WHERE THE TOXICITY IS OCCURRING RATHER THAN MYELINATION ISSUES.", "iAHluJapkkE-00836-00491746-00492950": ">> IF MEMORY SERVES ME CORRECTLY, I THINK TOX TEN IS KNOWN -- YOU PICKED THAT UP IN", "iAHluJapkkE-00837-00492950-00493251": "YOUR SCREEN. YOU COULD GO FURTHER WITH THAT, TOO.", "iAHluJapkkE-00838-00493251-00493563": ">> YES. WE'VE -- MAYBE YOU'RE THE ONE WE GOT THIS", "iAHluJapkkE-00839-00493563-00494006": "FROM. COLLABORATORS THAT HAVE GIVEN US KNOCK-OUT", "iAHluJapkkE-00840-00494006-00494533": "MICE FOR EACH OF THOSE FOUR, INCLUDING SOMEONE HERE AT THE NIH.", "iAHluJapkkE-00841-00494533-00494978": "I'M NOT DOING THOSE MOUSE EXPERIMENTS. WE'RE LOOKING IN TO MOUSE TO SEE IF WE CAN", "iAHluJapkkE-00842-00494978-00495344": "REPLICATE THIS THEN TAKE TO THE COLLABORATIVE PROCESS.", "iAHluJapkkE-00843-00495344-00495897": "WE HAVE THE KNOCK-OUT MICE. >> THANKS.", "iAHluJapkkE-00844-00495897-00496585": "GREAT TALK. [ NOT AUDIBLE ]", "iAHluJapkkE-00845-00496585-00496963": "THE QUESTION WAS, GOOD REVIEW ARTICLE FOR THE MARKERS ON DRUGS.", "iAHluJapkkE-00846-00496963-00497601": "THERE ARE A FEW OUT THERE. THERE'S NOT ONE WITHIN THE LAST SIX MONTHS", "iAHluJapkkE-00847-00497601-00498153": "THAT I CAN THINK OF THAT IS ESPECIALLY GOOD. IS THERE A WEBSITE FOR THIS?", "iAHluJapkkE-00848-00498153-00498884": "IF I SENT YOU SOME -- LET ME GO PULL THE ACTUAL CITING FOR COUPLE OF THOSE PUT IT UP ON THE", "iAHluJapkkE-00849-00498884-00500011": "WEBSITE. NEW ENGLAND HAD REVIEW, THAT WAS 2003.", "iAHluJapkkE-00850-00500011-00500553": "IT'S FAR OUT OF DATE. THERE'S COUPLE FROM 2008 THAT ARE GOOD.", "iAHluJapkkE-00851-00500553-00501634": "LOT ARE VERY SPECIFIC, THERE'S GREAT REVIEW ON THAT AUTO POX FIN PHARMACOGENETICH ABOUT", "iAHluJapkkE-00852-00501634-00502358": "EVERYTHING ELSE. >> FOR YOUR STUDY IN GHANA GROUP WHAT WERE", "iAHluJapkkE-00853-00502358-00502844": "YOUR SAMPLE SIZES. THEY PROBABLY WEREN'T AS BIG AS THE ONES AT", "iAHluJapkkE-00854-00502844-00503443": "NIH THAT YOU WERE POINTING OUT. >> IN GHANA, EACH TRANSCRIBE HAD 500 INDIVIDUALS.", "iAHluJapkkE-00855-00503443-00504227": "ENDS UP BEING 2500 PEOPLE. THE OTHER WAS HAPMAP, THAT WAS MUCH SMALLER", "iAHluJapkkE-00856-00504227-00505133": "ONLY 33 IF I REMEMBER CORRECTLY FOR THAT. THAT COULD BE INFLUENCING, CERTAINLY EURBANS", "iAHluJapkkE-00857-00505133-00506064": "THEY INDIVIDUALS DON'T REPRESENT ALL, OR NIGERIANS. IT COULD BE FROM THE GHANA STANDPOINT WOE", "iAHluJapkkE-00858-00506064-00506646": "HAVE GOOD NUMBERS. WE USE 500 FOR EACH POPULATION BASED ON OUR", "iAHluJapkkE-00859-00506646-00507196": "-- WE -- WE ASKED THE QUESTION HOW BIG A SAMPLE SIZE DO WE NEED TO BE ABLE TO DETECT", "iAHluJapkkE-00860-00507196-00507602": "SOME OF THE RARE VARIANTS WITH AT LEAST DOUBLING OF INCIDENTS.", "iAHluJapkkE-00861-00507602-00508322": "THAT'S WHY WE'RE DOING 500 PER POPULATION. >> YOU WOULD SEE THAT MUCH VARIATION MORE", "iAHluJapkkE-00862-00508322-00508627": "IN -- >> WE SEE IT ALL OVER THE PLACE.", "iAHluJapkkE-00863-00508627-00509142": "I DON'T KNOW IF YOU PROBABLY NOTICE ON THIS PARTICULAR SLIDE THERE WAS VERY HIGH INCIDENTS", "iAHluJapkkE-00864-00509142-00510061": "IN BULGARIA, PERU, WE DON'T HAVE A CLUE WHY. PROBABLY NEVER WILL HAVE A CLUE WHY.", "iAHluJapkkE-00865-00510061-00510558": "CERTAIN POPULATIONS SEEM TO HAVE -- EVEN POPULATIONS IF YOU LOOKED AT A MILLION SNP CHIPS WOULD", "iAHluJapkkE-00866-00510558-00510800": "BE IDENTICAL. WE'RE TALKING ABOUT INDIVIDUAL'S DECISION", "iAHluJapkkE-00867-00510800-00511458": "BASED ON ONE OR VERY SMALL NUMBER OF VARIANTS. ALL OF THE DATA THAT HELPS SOMEONE BE SIMILAR", "iAHluJapkkE-00868-00511458-00512063": "GOES AWAY. [ NOT AUDIBLE ]", "iAHluJapkkE-00869-00512063-00512835": ">> WE CURRENTLY USE THE CHIP WHICH HAS NOR OF VARIANTS THAT WE NEED THAN SOME OF THE", "iAHluJapkkE-00870-00512835-00513175": "OTHER PRODUCTS THAT ARE OUT THERE. WE NEED TO SUPPLEMENT WITH THE HLA MARKERS", "iAHluJapkkE-00871-00513175-00513868": "AND FOR SOME OF THE PHARMACODYNAMIC GENES THAT ARE OUT THERE.", "iAHluJapkkE-00872-00513868-00514493": "[ NOT AUDIBLE ] >> WE ARE HAVING A DEBATE IN A CIRCLE ABOUT", "iAHluJapkkE-00873-00514493-00515438": "UTILITY OF HAPPEN HAPPEN CELL PANEL -- IS THAT PANEL BEING LARGELY USED TO IDENTIFY", "iAHluJapkkE-00874-00515438-00515872": "THE TARGETS OR IS IT BEING USED TO FIND NEW DRUGS.", "iAHluJapkkE-00875-00515872-00516546": "IS IT DRUG DISCOVERY FOR TARGET VALIDATION. >> I'M NOT A BIG FAN OF USING THE HAPMAP CELL", "iAHluJapkkE-00876-00516546-00517142": "LINES FOR DISCOVERY. I WAS A BIG FAN UNTIL OUR STATISTICIANS -- AND", "iAHluJapkkE-00877-00517142-00517597": "THERE'S JUST HUGE AMOUNT OF DATA. BACK TO THE SCOTTISH THING.", "iAHluJapkkE-00878-00517597-00518355": "I THOUGHT I WOULD BE ABLE TO GO IN, GET THE GENOME FOR FREE BE GREAT.", "iAHluJapkkE-00879-00518355-00518971": "YOU DO GENOME FOR FREE BUT SO FEW SAMPLES THAT IF YOU PUT THEM ALTOGETHER IT'S 270 CELL", "iAHluJapkkE-00880-00518971-00519631": "LINES. FOR A LOT OF THE MARKERS THAT WE'RE TALKING", "iAHluJapkkE-00881-00519631-00519815": "ABOUT. WE'VE MOVED AWAY FROM THAT.", "iAHluJapkkE-00882-00519815-00520642": "WE NOW HAVE COLLECTIONS OF UNRELATED INDIVIDUALS, WE HAVE A THOUSAND, JUST OVER A THOUSAND EUROPEAN", "iAHluJapkkE-00883-00520642-00521185": "AMERICANS, A THOUSAND AFRICAN AMERICANS AND THOUSAND TAIWANESE WHERE WE HAVE IMMORTLIZED", "iAHluJapkkE-00884-00521185-00521769": "AND TRANSFORMED MONONUCLEAR CELLS WE DO DISCOVERY IN THAT WAY.", "iAHluJapkkE-00885-00521769-00522396": "WE HAD ENOUGH POWER. SEVERAL OF MY COLLEAGUES DO USE HAPMAP ON", "iAHluJapkkE-00886-00522396-00522623": "REGULAR BASIS. THEY BELIEVE WHAT THEY FIND.", "iAHluJapkkE-00887-00522623-00523434": "THEY KNOW MY OPINION AND MORE POWER TO THEM. THEY ARE DOING GOOD QUALITY WORK.", "iAHluJapkkE-00888-00523434-00524238": "I JUST DON'T HAPPEN TO BELIEVE THEIR RESULTS. >> IN GENERAL, SHOULD WE BE CONCERNED WITH", "iAHluJapkkE-00889-00524238-00524992": "EWBV -- TRANSFORM CELLS? SHOULD WE BE CONCERNED ABOUT THAT?", "iAHluJapkkE-00890-00524992-00525388": ">> IT'S ONE OF THE NECESSARY EVIL THINGS MUCH UNTIL THERE'S A BETTER WAY OF DOING IT ABOUT", "iAHluJapkkE-00891-00525388-00526240": "THE ONLY OPTION WE HAVE. WE LOOK AT BOTH COPY NUMBER AS WELL AS EXPRESSION", "iAHluJapkkE-00892-00526240-00527311": "OF SOME OF THE EBV OR -- CERTAIN PHASE THAT WE -- WE USE THAT PUT IT IN TO OUR PHYSICAL", "iAHluJapkkE-00893-00527311-00527963": "MODEL. SO FAR HAVE NOT SEEN A BIG AFFECT OF THAT.", "iAHluJapkkE-00894-00527963-00528642": "AND DID SEE -- MAINLY LOOKING AT CYTOSTATIC NOT CYTOTOXIC.", "iAHluJapkkE-00895-00528642-00529148": "I THINK THAT THE KEY THING THAT YOU LOOK, THERE'S SOME PEOPLE THAT AREN'T EVEN BOTHERING", "iAHluJapkkE-00896-00529148-00529908": "TO LOOK. THEIR RESULTS ARE HARD TO", "iAHluJapkkE-00897-00529908-00530382": "INTERPRET. DO YOU HAVE A QUESTION?", "iAHluJapkkE-00898-00530382-00530977": ">> YOU HAVE YOUR DATA WAS THE TOXICITY, YOU DID THE GWAS STUDY.", "iAHluJapkkE-00899-00530977-00531706": "HOW COME -- THE CANDIDATE SNPS THAT ARE IMPORTANT OR THE GWAS APPROACH IS GOING TO BE THE BEST", "iAHluJapkkE-00900-00531706-00532205": "WAY TO GO. >> CELL LINES -- ADVANTAGE OF OUR USE EVER", "iAHluJapkkE-00901-00532205-00532738": "CELL LINES WAS THAT WE COULD DO FAMILY STUDY ANDREA CAN DO DISCOVERY, LESS CELL LINES.", "iAHluJapkkE-00902-00532738-00533508": "THERE IS MANY DOWN SIDES TO USING CELL LINES. FIRST OF ALL ONLY REPRESENT ONE COMPARTMENT", "iAHluJapkkE-00903-00533508-00534236": "OF THE MANY TYPES OF CELLS IN THE BODY. WE SAY, CELL AUTONOMOUS APPROACH, OUR COP", "iAHluJapkkE-00904-00534236-00534621": "OUT. THERE'S LOT OF GENES THAT DOWN REGULATE IMMEDIATELY", "iAHluJapkkE-00905-00534621-00535107": "WHEN YOU GO IN TO CULTURE. DPYD IS ONE OF THEM.", "iAHluJapkkE-00906-00535107-00535730": "WE'VE SHOWN IN PEOPLE THAT ARE NOT TRANSFORMED THAT THEN COUPLE OF HOURS.", "iAHluJapkkE-00907-00535730-00536407": "THERE'S LESS THAN A TENTH OF THE ENZYME ACTIVITY STILL LEFT.", "iAHluJapkkE-00908-00536407-00537139": "THEY'RE NOT JUST GOING DOWN IN TERMS OF EXPRESSION THEY ARE ACTIVE DEGRADATION GOING ON OF THE", "iAHluJapkkE-00909-00537139-00537604": "PROTEIN. IN THAT CASE, IN THE CASE OF LOT OF THE P450", "iAHluJapkkE-00910-00537604-00538138": "ENZYMES THEY'RE NOT WELL REPRESENTED. WE REALLY LOOK AT THESE AS MORE OF PHARMACODYNAMIC", "iAHluJapkkE-00911-00538138-00538596": "APPROACH. THE PHARMACOKINETIC ASPECT ARE NOT GOING TO", "iAHluJapkkE-00912-00538596-00538977": "BE WELL REPRESENTED. BUT PHARMACOKINETIC YOU CAN DO THOSE STUDIES", "iAHluJapkkE-00913-00538977-00539299": "IN HUMANS MUCH EASIER, NOT IN FAMILIES BUT IN CERTAINLY PATIENTS.", "iAHluJapkkE-00914-00539299-00540050": "WE THOUGHT THAT WAS WORTHWHILE TRADE OFF. >> CAN YOU JUST COMMENT -- WE HAVE SHOWN THAT", "iAHluJapkkE-00915-00540050-00541131": "GLYCOPROTEIN POLYMORPHISMS, YOU JUST SHOWED THAT PROBABLY NOT SO IMPORTANT DO YOU THINK", "iAHluJapkkE-00916-00541131-00541517": "THESE CANDIDATE GENES APPROACH ARE GOOD? THEY'RE HYPOTHESIS DRIVEN OR DO YOU THINK", "iAHluJapkkE-00917-00541517-00542013": "THESE GWAS STUDIES WILL BE THE -- >> IF YOU HAVE GOOD BIOLOGICAL POSSIBILITY,", "iAHluJapkkE-00918-00542013-00542240": "ULTIMATE GOAL TO ASK THE QUESTIONS THIS VARIANT REAL.", "iAHluJapkkE-00919-00542240-00542865": "HAVING ENOUGH SAM PELTS TO ASK THAT QUESTION  -- SAMPLES TO PROSPECTIVELY PLAN IT EVEN", "iAHluJapkkE-00920-00542865-00543608": "IF IT'S RETROSPECTIVE DATA SET IS KEY. IN TERMS OF GWAS ESPECIALLY WITH THE PHARMACOLOGY", "iAHluJapkkE-00921-00543608-00544334": "THAT PHARMACOKINETIC PART THE P450S ARE EITHER ABSENT OR VERY POORLY TAGGED WITH THE TWO", "iAHluJapkkE-00922-00544334-00544982": "AVAILABLE SNP CHIPS. WHILE YOU HAVE MILLION CHIPS, YOU HAVE DESERTS", "iAHluJapkkE-00923-00544982-00545432": "AROUND THE P450. DATE THAT THAT SNPS THAT ARE IN SOME OF THOSE", "iAHluJapkkE-00924-00545432-00545758": "I JUST DON'T BELIEVE AT ALL. IT'S BECAUSE OF THE GENOME ISSUES.", "iAHluJapkkE-00925-00545758-00546711": "IT'S VERY HARD -- WITH THE CURRENT TECHNOLOGY APPROACH TO CONVERT THOSE ASSAYS, ONLY REASON", "iAHluJapkkE-00926-00546711-00547254": "THAT WORKS SO WELL THEY USE CONVERSION PROBE TECHNOLOGY WHICH IS ABLE TO LAY DOWN NICELY.", "iAHluJapkkE-00927-00547254-00547982": "BUT EVEN WITHIN THE PRODUCT, THE CHIP WORKS WELL FOR P450, THE P450 IS USEFUL.", "iAHluJapkkE-00928-00547982-00549307": ">> THERE IS AN INSTANCE WHERE STATINS, FOR EXAMPLE, YOU HAVE -- THERE'S CLEARLY SOME", "iAHluJapkkE-00929-00549307-00549700": "REPRESENTATION. NOT AS WELL COVERED.", "iAHluJapkkE-00930-00549700-00549936": ">> THAT WAS TRANSPORTER, THEY GOT LUCKY, THAT'S GREAT.", "iAHluJapkkE-00931-00549936-00551259": "LUCK IS GOOD. >> IT WAS FUNNILY BECAUSE IT WAS -- ANYWAY,", "iAHluJapkkE-00932-00551259-00552055": "THANKS A LOT. I APPRECIATE IT.", "iAHluJapkkE-00933-00552055-00552923": "[ NOT AUDIBLE ] >> THE QUESTION, THE QUESTION ABOUT COMPLEMENTARY", "iAHluJapkkE-00934-00552923-00553715": "TECHNIQUES FOR PICKING UP -- [ NOT AUDIBLE ]", "iAHluJapkkE-00935-00553715-00554146": "WE ARE LOOKING AT OTHER TECHNIQUES TO FIND OTHER SNPS AS DISCOVERY APPROACH.", "iAHluJapkkE-00936-00554146-00555677": "WE CURRENTLY ARE NOT.", "iAHluJapkkE-00937-00555677-00557087": "AT SOME OF THE OTHER -- I GUESS METHYLATION, MORE CHROMATIN -- EPIGENETIC ISSUES.", "iAHluJapkkE-00938-00557087-00557779": "HE'S ABLE TO SHOW NICE DATA ON THE CELL LINES, NOW GOING TO USE SOME OF OUR PATIENT SAMPLES", "iAHluJapkkE-00939-00557779-00558344": "AND SEE WHETHER THAT TECHNIQUE CAN ACTUALLY GET SOME RESULTS THAT ARE ROBUST.", "iAHluJapkkE-00940-00558344-00558813": "SO THAT WOULD OPEN IT UP FOR US THERE. IN OUR STUDIES WHERE WE HAVE TUMOR WE'RE ABLE", "iAHluJapkkE-00941-00558813-00559289": "TO LOOK AT METHYLATION DIFFERENCES BETWEEN TUMOR AND NORMAL OR BETWEEN TUMORS FROM RESPONDERS", "iAHluJapkkE-00942-00559289-00560028": "AND NONRESPONDERS WE CERTAINLY BELIEVE THAT GENETICS, THAT DNA IS ONLY ONE PART OF VERY", "iAHluJapkkE-00943-00560028-00560544": "COMPLEX ISSUE. SO AS TECHNIQUES GET BETTER FOR THE LATE TRANSLATION", "iAHluJapkkE-00944-00560544-00561148": "STUFF WE'RE EAGER TO APPLY THEM. WE KNOW THAT DNA WILL NOT BE ENOUGH.", "iAHluJapkkE-00945-00561148-00561332": "OR AT LEAST GENOTYPING SNPS THEY WILL NOT BE ENOUGH.", "iAHluJapkkE-00946-00561332-00561353": "THANK YOU."}}, {"audio_id": "iAIVIEpA67u", "text": {"iAIVIEpA67u-00000-00000000-00000200": "HOFU UDON", "iAIVIEpA67u-00001-00000200-00000400": "Taman Jajan CBD Bintaro", "iAIVIEpA67u-00002-00000400-00000600": "Japanese food", "iAIVIEpA67u-00003-00000600-00000800": "Delicious and cheap", "iAIVIEpA67u-00004-00000800-00001000": "Indonesian street food"}}, {"audio_id": "iB1gq_QBvO4", "text": {"iB1gq_QBvO4-00000-00000042-00001170": "Hello everyone. My name is Yakiv. I am 30 years old. I want to tell you about my work", "iB1gq_QBvO4-00001-00001170-00001932": "experience and something about me. Okay, let's get started. And the first role. My career started", "iB1gq_QBvO4-00002-00001932-00002736": "with a call center where I was a consultant. Then I worked as a sales manager for tariff", "iB1gq_QBvO4-00003-00002736-00003540": "plants and services of a mobile operator. And then I worked as the recruiter and was looking", "iB1gq_QBvO4-00004-00003540-00004452": "for personnel for the company, for the agency. I am a proactive and goal-oriented person. I like", "iB1gq_QBvO4-00005-00004452-00005340": "to develop and learn new things every time. And I like to read books and I like tourism.", "iB1gq_QBvO4-00006-00005478-00006042": "My life credo is to work according to the Pareto principle, and I want", "iB1gq_QBvO4-00007-00006042-00006845": "to be in that 20 percent of people who bring 80% of success to the company.", "iB1gq_QBvO4-00008-00006845-00007356": "Okay, that's all, thank you so much for your attention. Have a nice day. Bye."}}, {"audio_id": "iB6sHp7ecAA", "text": {"iB6sHp7ecAA-00000-00000375-00000496": "No, no time.", "iB6sHp7ecAA-00001-00000597-00000688": "We didn't have any time.", "iB6sHp7ecAA-00002-00000775-00001538": "Welcome everyone to the February 2023 DC Community call.", "iB6sHp7ecAA-00003-00001542-00001772": "It's it's been exciting few months.", "iB6sHp7ecAA-00004-00001773-00002435": "I look at that GAIL, showing off his his lovely DSC hoodie.", "iB6sHp7ecAA-00005-00002439-00002982": "They're looks warm, so to today we are.", "iB6sHp7ecAA-00006-00002983-00003119": "We are we joined by Demetrius.", "iB6sHp7ecAA-00007-00003194-00003279": "Don't see him on the call yet.", "iB6sHp7ecAA-00008-00003357-00003369": "Yes.", "iB6sHp7ecAA-00009-00003408-00003453": "We do.", "iB6sHp7ecAA-00010-00003454-00003499": "We do.", "iB6sHp7ecAA-00011-00003496-00003575": "Error is.", "iB6sHp7ecAA-00012-00003500-00003866": "Hey, we are we doing joined by demitrius, we cause demitrius", "iB6sHp7ecAA-00013-00003866-00004089": "gonna got to get away in 35 minutes.", "iB6sHp7ecAA-00014-00004090-00004467": "We're gonna jump straight in, but we have had some releases", "iB6sHp7ecAA-00015-00004467-00004631": "over the last few minutes.", "iB6sHp7ecAA-00016-00004632-00004784": "We obviously been working on a bunch of stuff.", "iB6sHp7ecAA-00017-00004957-00005428": "The two releases that I know that are currently been working", "iB6sHp7ecAA-00018-00005428-00005900": "on there was storage DSC 5.1 came out that added support for", "iB6sHp7ecAA-00019-00005900-00006055": "selecting the disks.", "iB6sHp7ecAA-00020-00006122-00006166": "Uh.", "iB6sHp7ecAA-00021-00006192-00006605": "By serial number and by GUID.", "iB6sHp7ecAA-00022-00006642-00006953": "So you can that supports more Azure scenarios.", "iB6sHp7ecAA-00023-00006954-00007360": "Now I'm computer management, can't remember off the top of my", "iB6sHp7ecAA-00024-00007360-00007759": "head, but that is 9.0 is not a breaking change that went out", "iB6sHp7ecAA-00025-00007759-00008152": "just it's just going out now that's been sitting in preview", "iB6sHp7ecAA-00026-00008152-00008290": "for for a few months.", "iB6sHp7ecAA-00027-00008478-00008597": "So check those out.", "iB6sHp7ecAA-00028-00008598-00008826": "Any Johan any releases on your side?", "iB6sHp7ecAA-00029-00009064-00009118": "No, it's been.", "iB6sHp7ecAA-00030-00009064-00009158": "I have one as well.", "iB6sHp7ecAA-00031-00009117-00009169": "Or that you.", "iB6sHp7ecAA-00032-00009297-00009446": "OK, we have.", "iB6sHp7ecAA-00033-00009563-00009708": "OK, OK.", "iB6sHp7ecAA-00034-00009661-00009928": "There's a pre release of update services DSC.", "iB6sHp7ecAA-00035-00009991-00010439": "There was, I think, bug fixes must mostly about language", "iB6sHp7ecAA-00036-00010439-00010510": "settings.", "iB6sHp7ecAA-00037-00010535-00010823": "I don't know the details anymore, but I did service", "iB6sHp7ecAA-00038-00010823-00010912": "update services.", "iB6sHp7ecAA-00039-00010913-00011204": "DSC has been updated it just approval is not a full release.", "iB6sHp7ecAA-00040-00011328-00011395": "Awesome.", "iB6sHp7ecAA-00041-00011428-00011686": "And yeah, and you're him.", "iB6sHp7ecAA-00042-00011458-00011478": "Yeah.", "iB6sHp7ecAA-00043-00011751-00011924": "Yeah, and config manager.", "iB6sHp7ecAA-00044-00011925-00012212": "CBD SEL also needs to have version four.", "iB6sHp7ecAA-00045-00012348-00012940": "Then there's just a few preview the thesis and sequels RDC.", "iB6sHp7ecAA-00046-00012951-00013244": "We're gonna really release that eventually.", "iB6sHp7ecAA-00047-00013249-00013716": "It's not been previews 17 now, so we have to fix the things", "iB6sHp7ecAA-00048-00013716-00014130": "with the class based resources before we release it.", "iB6sHp7ecAA-00049-00014211-00014446": "I haven't had time, but some.", "iB6sHp7ecAA-00050-00014249-00014286": "Gotcha.", "iB6sHp7ecAA-00051-00014429-00014610": "So if you not awesome, we'll.", "iB6sHp7ecAA-00052-00014611-00015034": "Hey, look, if you are waiting for any releases and your fix or", "iB6sHp7ecAA-00053-00015034-00015463": "patch or feature is in preview and you need that in final form,", "iB6sHp7ecAA-00054-00015463-00015578": "can use it later.", "iB6sHp7ecAA-00055-00015583-00015808": "Let them maintain a know.", "iB6sHp7ecAA-00056-00015832-00016318": "Often we keep these in preview for a little bit longer than we", "iB6sHp7ecAA-00057-00016318-00016811": "should, so just prompt us, but let's any announcements, GAIL on", "iB6sHp7ecAA-00058-00016811-00017259": "your side in regards events coming up, you are the events", "iB6sHp7ecAA-00059-00017259-00017290": "guy.", "iB6sHp7ecAA-00060-00017491-00017518": "Yeah.", "iB6sHp7ecAA-00061-00017519-00017966": "Next week we I'm going to London for the PowerShell Days UK.", "iB6sHp7ecAA-00062-00017967-00018478": "So we're doing PS UK next next week and then the others usual", "iB6sHp7ecAA-00063-00018478-00018553": "suspects.", "iB6sHp7ecAA-00064-00018554-00018975": "That would be the PowerShell Conference Europe in June in", "iB6sHp7ecAA-00065-00018975-00019026": "Prague.", "iB6sHp7ecAA-00066-00019031-00019367": "And then there's also, but I need from someone from the US to", "iB6sHp7ecAA-00067-00019367-00019492": "help me with the dates.", "iB6sHp7ecAA-00068-00019493-00019985": "There's also the PowerShell and DevOps submit in Bellevue that", "iB6sHp7ecAA-00069-00019985-00020204": "will be in I believe, April.", "iB6sHp7ecAA-00070-00020205-00020655": "I can't remember the exact dates, but we'll put the links", "iB6sHp7ecAA-00071-00020541-00021136": "Our league, but the lengths or some Jody after Demetrius is", "iB6sHp7ecAA-00072-00020655-00020741": "later. Yep.", "iB6sHp7ecAA-00073-00021136-00021305": "gonna do his bit.", "iB6sHp7ecAA-00074-00021306-00021538": "Jodi's gonna stick around hopefully.", "iB6sHp7ecAA-00075-00021539-00021925": "Thanks Jody, and share a little bit Phillips on the the updates", "iB6sHp7ecAA-00076-00021925-00022275": "on her side, but yeah, let's demitrius you really do kick", "iB6sHp7ecAA-00077-00022275-00022300": "off.", "iB6sHp7ecAA-00078-00022514-00022583": "You bet.", "iB6sHp7ecAA-00079-00022584-00022901": "So I'll give kind of a little bit of an intro and then I'll", "iB6sHp7ecAA-00080-00022642-00022698": "You bet.", "iB6sHp7ecAA-00081-00022901-00023029": "let John do a demo here.", "iB6sHp7ecAA-00082-00023084-00023401": "Last time around we talked a little bit about the DSC", "iB6sHp7ecAA-00083-00023401-00023736": "resources that we're building for winget so that you can", "iB6sHp7ecAA-00084-00023736-00024036": "manage your both user and administrative settings.", "iB6sHp7ecAA-00085-00024037-00024321": "And we've been working on a DSC resource that will help", "iB6sHp7ecAA-00086-00024321-00024561": "bootstrap wingit and get it into a good state.", "iB6sHp7ecAA-00087-00024614-00024755": "We're still doing a little bit of work there.", "iB6sHp7ecAA-00088-00024756-00025082": "We've got some fun with one of our dependencies that we're not", "iB6sHp7ecAA-00089-00025082-00025413": "thrilled with how it's packaged, so we're still doing some work", "iB6sHp7ecAA-00090-00025413-00025709": "on that and a new issue was added fairly recently by the", "iB6sHp7ecAA-00091-00025709-00026020": "Power Toys team where they're saying, hey, Wingate is great", "iB6sHp7ecAA-00092-00026020-00026341": "for installing stuff, but I've got a few more things I'd like", "iB6sHp7ecAA-00093-00026341-00026569": "to be able to do in terms of configuration.", "iB6sHp7ecAA-00094-00026601-00026917": "So we've started looking at the work working with PowerShell", "iB6sHp7ecAA-00095-00026917-00026948": "teams.", "iB6sHp7ecAA-00096-00026949-00027336": "Steve Lee and Jason Helmick and a few others there looking at", "iB6sHp7ecAA-00097-00027336-00027718": "having winget act as a local configuration manager and being", "iB6sHp7ecAA-00098-00027718-00027918": "able to run invoke DSC resource.", "iB6sHp7ecAA-00099-00027967-00028293": "But what we're looking at is a declarative file that will parse", "iB6sHp7ecAA-00100-00028293-00028584": "to figure out what resources need to be run and what the", "iB6sHp7ecAA-00101-00028584-00028661": "properties are.", "iB6sHp7ecAA-00102-00028737-00028994": "So with that, I will hand it over to John and let him do a", "iB6sHp7ecAA-00103-00028994-00029016": "demo.", "iB6sHp7ecAA-00104-00029382-00029431": "Raising.", "iB6sHp7ecAA-00105-00029402-00029447": "Hi.", "iB6sHp7ecAA-00106-00029687-00029829": "I guess let's see.", "iB6sHp7ecAA-00107-00030277-00030374": "Share this screen.", "iB6sHp7ecAA-00108-00030631-00031077": "Uh, quickly, I guess you mentioned the resources.", "iB6sHp7ecAA-00109-00031077-00031181": "I don't know.", "iB6sHp7ecAA-00110-00031254-00031413": "I don't have like a.", "iB6sHp7ecAA-00111-00031426-00031891": "What's the right way to demo a resource other than walking", "iB6sHp7ecAA-00112-00031891-00032057": "through what's in it?", "iB6sHp7ecAA-00113-00032161-00032547": "Umm yeah, we added the the user settings the admin.", "iB6sHp7ecAA-00114-00032502-00032639": "Can you make it a little bigger?", "iB6sHp7ecAA-00115-00032651-00033126": "Uh, yes, if I can figure out no control doesn't work.", "iB6sHp7ecAA-00116-00033127-00033270": "Alright, Visual Studio code.", "iB6sHp7ecAA-00117-00033313-00033530": "Actually, how do I make Visual Studio code zoom?", "iB6sHp7ecAA-00118-00033453-00033529": "Yeah, control plus.", "iB6sHp7ecAA-00119-00033593-00033676": "In trophyless Yep.", "iB6sHp7ecAA-00120-00033723-00034108": "Ohh I didn't uh, I just tried control scroll and it didn't", "iB6sHp7ecAA-00121-00034108-00034141": "work.", "iB6sHp7ecAA-00122-00034391-00034415": "Is that?", "iB6sHp7ecAA-00123-00034683-00034709": "Good.", "iB6sHp7ecAA-00124-00034769-00034898": "Now perfect.", "iB6sHp7ecAA-00125-00034842-00035062": "All right, ohm.", "iB6sHp7ecAA-00126-00035170-00035454": "So yeah, we had the user settings resource.", "iB6sHp7ecAA-00127-00035730-00036258": "Which is basically just lets you set the all the JSON the admin", "iB6sHp7ecAA-00128-00036258-00036333": "settings.", "iB6sHp7ecAA-00129-00036398-00036666": "Again, there's just a handful of these.", "iB6sHp7ecAA-00130-00037203-00037553": "This source is is similar, although I think we need to", "iB6sHp7ecAA-00131-00037553-00037903": "actually work on this one a little bit in terms of our", "iB6sHp7ecAA-00132-00037903-00038291": "layout and then the package is the big one of actual package", "iB6sHp7ecAA-00133-00038291-00038711": "management where you can specify the package you want the version", "iB6sHp7ecAA-00134-00038711-00039112": "you want, where it comes from, whether it do get it or get rid", "iB6sHp7ecAA-00135-00039112-00039182": "of it. Umm.", "iB6sHp7ecAA-00136-00039517-00039978": "If I again, I don't really know what the best way to to show off", "iB6sHp7ecAA-00137-00039978-00040277": "a resources, so if someone has questions.", "iB6sHp7ecAA-00138-00040635-00040760": "So how do you use that?", "iB6sHp7ecAA-00139-00040761-00041183": "So basically you have you have resources for Wingard package,", "iB6sHp7ecAA-00140-00041183-00041612": "so I guess you just ensure that the package is present in this", "iB6sHp7ecAA-00141-00041186-00041217": "Yep.", "iB6sHp7ecAA-00142-00041612-00042034": "case looking at the code and then you say so you just provide", "iB6sHp7ecAA-00143-00041852-00041872": "Yeah.", "iB6sHp7ecAA-00144-00042034-00042470": "the information and say I want all of those packages installed.", "iB6sHp7ecAA-00145-00042508-00042690": "Umm Yep.", "iB6sHp7ecAA-00146-00042529-00043020": "Please make it so and then winget makes it so so so you can", "iB6sHp7ecAA-00147-00043016-00043048": "Correct.", "iB6sHp7ecAA-00148-00043020-00043495": "just you can just provide it like a bunch of packages you", "iB6sHp7ecAA-00149-00043495-00044020": "want to have installed and then everything else will get a win.", "iB6sHp7ecAA-00150-00044021-00044268": "Get will just apply it using DSC.", "iB6sHp7ecAA-00151-00044269-00044325": "Is that correct?", "iB6sHp7ecAA-00152-00044376-00044406": "Correct.", "iB6sHp7ecAA-00153-00044521-00044790": "Ohh I think yeah.", "iB6sHp7ecAA-00154-00044629-00044923": "So ohh, go ahead if you had.", "iB6sHp7ecAA-00155-00044791-00044817": "Good.", "iB6sHp7ecAA-00156-00044941-00045096": "No, there, there's Danielle with the question.", "iB6sHp7ecAA-00157-00045106-00045222": "He's got his hands up.", "iB6sHp7ecAA-00158-00045223-00045317": "That's all I wanted to say.", "iB6sHp7ecAA-00159-00045224-00045425": "Yeah, I look, I I thought I'd raise my hand.", "iB6sHp7ecAA-00160-00045426-00045455": "Yeah.", "iB6sHp7ecAA-00161-00045456-00045778": "And also obviously this is gonna deploy packages.", "iB6sHp7ecAA-00162-00045788-00046180": "Is there also a way for you to say I the state should be that", "iB6sHp7ecAA-00163-00046180-00046573": "this particular package isn't installed and I guess the other", "iB6sHp7ecAA-00164-00046573-00046959": "thing would be can we enforce or pin a specific version of a", "iB6sHp7ecAA-00165-00046959-00047061": "package as well?", "iB6sHp7ecAA-00166-00047067-00047498": "And I'm assuming those are definite, but those are boys.", "iB6sHp7ecAA-00167-00047464-00047951": "So that you can definitely select as a version in here and", "iB6sHp7ecAA-00168-00047499-00047573": "Questions people have.", "iB6sHp7ecAA-00169-00047951-00048430": "you can use the insurer to ensure absent to remove it the", "iB6sHp7ecAA-00170-00048430-00048571": "when you say pen.", "iB6sHp7ecAA-00171-00048572-00048855": "I don't know if you're referring to our sort of new feature", "iB6sHp7ecAA-00172-00048855-00049119": "that's coming in that is actually having wingit pin the", "iB6sHp7ecAA-00173-00049119-00049195": "package version.", "iB6sHp7ecAA-00174-00049196-00049258": "So it won't.", "iB6sHp7ecAA-00175-00049262-00049601": "It won't attempt to update it, or if you meant pen as an you", "iB6sHp7ecAA-00176-00049601-00049846": "can select the version of the DSC resource.", "iB6sHp7ecAA-00177-00049934-00050318": "I actually meant the the latter, but the former sounds awesome as", "iB6sHp7ecAA-00178-00050318-00050679": "well, so I have the yeah, the formal sounds awesome if you if", "iB6sHp7ecAA-00179-00050679-00050889": "you're planning to do that as well.", "iB6sHp7ecAA-00180-00050932-00051113": "So yeah, the the version selection.", "iB6sHp7ecAA-00181-00051114-00051576": "It'll if if the version happens to be higher, we will uninstall", "iB6sHp7ecAA-00182-00051576-00052024": "and reinstall because it's not always safe to just downgrade,", "iB6sHp7ecAA-00183-00052024-00052451": "and sometimes the installers won't even do it, and then if", "iB6sHp7ecAA-00184-00052451-00052906": "it's newer it will update if it happens to match, tests should", "iB6sHp7ecAA-00185-00052906-00053152": "succeed and we won't do anything.", "iB6sHp7ecAA-00186-00053305-00053707": "And so this will of course store install packages from the", "iB6sHp7ecAA-00187-00053707-00053994": "Microsoft Store as well, if if available.", "iB6sHp7ecAA-00188-00053933-00054058": "Correct.", "iB6sHp7ecAA-00189-00054075-00054416": "Unfortunately, they do not yet give us the version numbers.", "iB6sHp7ecAA-00190-00054425-00054763": "We continue to push on them to give us version numbers of their", "iB6sHp7ecAA-00191-00054763-00054996": "packages, but right now we don't have that.", "iB6sHp7ecAA-00192-00054997-00055441": "So we can't really specify if you if you specify a version, we", "iB6sHp7ecAA-00193-00055441-00055886": "can usually detect if it is the current one, but we don't know", "iB6sHp7ecAA-00194-00055886-00056253": "what's gonna happen when we install from the store.", "iB6sHp7ecAA-00195-00056254-00056568": "So it's basically we we try it and hope that the version you", "iB6sHp7ecAA-00196-00056568-00056801": "wanted is the one that happened to be there.", "iB6sHp7ecAA-00197-00056911-00056952": "That's all.", "iB6sHp7ecAA-00198-00056916-00057318": "So so it will automatically install the latest version on", "iB6sHp7ecAA-00199-00057318-00057436": "the store if you.", "iB6sHp7ecAA-00200-00057442-00057769": "If so, if it detects if the DSC resource detects that oh, it's", "iB6sHp7ecAA-00201-00057769-00058085": "not the right version, then you say, OK, install it from the", "iB6sHp7ecAA-00202-00058085-00058319": "store and that's gonna be taking the latest.", "iB6sHp7ecAA-00203-00058341-00058437": "On the store, correct.", "iB6sHp7ecAA-00204-00058365-00058784": "Umm, actually I'm not.", "iB6sHp7ecAA-00205-00058785-00059098": "I didn't write it, so I'm not 100% sure, but I think maybe if", "iB6sHp7ecAA-00206-00059098-00059390": "you specify a version from the store it may actually fail", "iB6sHp7ecAA-00207-00059210-00059241": "OK.", "iB6sHp7ecAA-00208-00059390-00059608": "because we don't know what the version is.", "iB6sHp7ecAA-00209-00059609-00059889": "So we might just get into a state of we don't want to do the", "iB6sHp7ecAA-00210-00059889-00060067": "wrong thing, so let's not do anything.", "iB6sHp7ecAA-00211-00060146-00060184": "OK.", "iB6sHp7ecAA-00212-00060166-00060528": "I think that I think that's gonna be the behavior and we've", "iB6sHp7ecAA-00213-00060528-00060859": "gotten partial support out of the store for the win 32", "iB6sHp7ecAA-00214-00060859-00060914": "packages.", "iB6sHp7ecAA-00215-00060963-00061210": "It is in one of the endpoints and the rest API.", "iB6sHp7ecAA-00216-00061211-00061590": "Unfortunately, it's not the one we use to do our version", "iB6sHp7ecAA-00217-00061262-00061330": "Oh, that's true.", "iB6sHp7ecAA-00218-00061590-00062023": "comparison logic, so we've asked them to add that for the win 32", "iB6sHp7ecAA-00219-00062023-00062397": "side on the sort of legacy packaged apps from the store", "iB6sHp7ecAA-00220-00062397-00062829": "right now, there's no mechanism for us to get the version there.", "iB6sHp7ecAA-00221-00062830-00063190": "We've been asking that and that is sort of a very long pull item", "iB6sHp7ecAA-00222-00063190-00063240": "for that.", "iB6sHp7ecAA-00223-00063241-00063521": "That leads into lots of really, really old legacy code.", "iB6sHp7ecAA-00224-00063749-00063800": "OK, OK.", "iB6sHp7ecAA-00225-00063836-00064191": "So I guess what this looks like sort of rolls into the", "iB6sHp7ecAA-00226-00064191-00064566": "configuration stuff that demitrius was talking about, and", "iB6sHp7ecAA-00227-00064566-00064961": "I have a sample file file here using some of these settings.", "iB6sHp7ecAA-00228-00064994-00065311": "This schema is totally.", "iB6sHp7ecAA-00229-00065480-00065517": "Uh.", "iB6sHp7ecAA-00230-00065519-00065624": "Malleable still.", "iB6sHp7ecAA-00231-00065625-00066087": "So, you know, I don't don't take it as gospel.", "iB6sHp7ecAA-00232-00066167-00066210": "Umm.", "iB6sHp7ecAA-00233-00066363-00066844": "But here's the actual install a package if you want good old", "iB6sHp7ecAA-00234-00066844-00066923": "notepad++.", "iB6sHp7ecAA-00235-00067016-00067538": "Just give it to ID, give it the source and off it can go", "iB6sHp7ecAA-00236-00067538-00068078": "unfortunately, because I put this all together at the last", "iB6sHp7ecAA-00237-00068078-00068216": "minute and the.", "iB6sHp7ecAA-00238-00068536-00068702": "And I just made this work last night.", "iB6sHp7ecAA-00239-00068853-00069280": "Some of these things are failing, but yeah.", "iB6sHp7ecAA-00240-00068909-00068927": "Yeah.", "iB6sHp7ecAA-00241-00069018-00069089": "Yeah, this is.", "iB6sHp7ecAA-00242-00069094-00069291": "This is very hot off the presses.", "iB6sHp7ecAA-00243-00069292-00069632": "It's not checked into when get CLI yet it will show up as a PR,", "iB6sHp7ecAA-00244-00069632-00069978": "probably in the next week or so, and then we'll be able to start", "iB6sHp7ecAA-00245-00069978-00070313": "sharing more of this where you can actually go grab these bits", "iB6sHp7ecAA-00246-00070313-00070452": "and play with it yourself.", "iB6sHp7ecAA-00247-00070567-00070820": "So this is the configure command in Wingit.", "iB6sHp7ecAA-00248-00070821-00071122": "We're working on the PowerShell module as well, so don't don't", "iB6sHp7ecAA-00249-00071104-00071275": "Can you make that one bigger as well please?", "iB6sHp7ecAA-00250-00071122-00071189": "feel left out.", "iB6sHp7ecAA-00251-00071255-00071323": "Oh, OK.", "iB6sHp7ecAA-00252-00071276-00071367": "The the window.", "iB6sHp7ecAA-00253-00071380-00071435": "Yeah, it is.", "iB6sHp7ecAA-00254-00071500-00071547": "Yeah.", "iB6sHp7ecAA-00255-00071548-00071802": "Sorry, let's make the window bigger as well.", "iB6sHp7ecAA-00256-00071925-00071973": "Just do this.", "iB6sHp7ecAA-00257-00072075-00072122": "Perfect.", "iB6sHp7ecAA-00258-00072133-00072169": "Thank you.", "iB6sHp7ecAA-00259-00072168-00072196": "OK.", "iB6sHp7ecAA-00260-00072480-00072936": "So that just, you know, sort of spits out what we're gonna do.", "iB6sHp7ecAA-00261-00072937-00073213": "It actually is pulling information from the local", "iB6sHp7ecAA-00262-00073213-00073258": "modules.", "iB6sHp7ecAA-00263-00073295-00073747": "It'll pull it from the gallery as well if it needs it to tell", "iB6sHp7ecAA-00264-00073747-00073937": "you what it's going to do.", "iB6sHp7ecAA-00265-00073943-00074084": "Again, these are all failing.", "iB6sHp7ecAA-00266-00074085-00074535": "I just wanted to run it, so if I say yes, it's gonna do that.", "iB6sHp7ecAA-00267-00074545-00074933": "Unfortunately, some other problems.", "iB6sHp7ecAA-00268-00074853-00074899": "Yeah. OK.", "iB6sHp7ecAA-00269-00075031-00075222": "Yeah, it's it.", "iB6sHp7ecAA-00270-00075223-00075337": "It work in progress, right?", "iB6sHp7ecAA-00271-00075338-00075442": "But it's good to see that.", "iB6sHp7ecAA-00272-00075344-00075360": "Yeah.", "iB6sHp7ecAA-00273-00075379-00075401": "Umm.", "iB6sHp7ecAA-00274-00075451-00075806": "So that means I'm basically what we can get is.", "iB6sHp7ecAA-00275-00075812-00076185": "Let me I'm just trying to understand from what you've just", "iB6sHp7ecAA-00276-00076185-00076545": "shown, winget can apply resources based on what you give", "iB6sHp7ecAA-00277-00076545-00076937": "and then the resources can be win, get package and the WINGET", "iB6sHp7ecAA-00278-00076937-00077322": "package can just say hey, make sure this is installed so you", "iB6sHp7ecAA-00279-00077322-00077720": "have the package and then what kind of other resources will be", "iB6sHp7ecAA-00280-00077720-00077784": "supported.", "iB6sHp7ecAA-00281-00077785-00078053": "So I guess if you installed resource studio code or if you", "iB6sHp7ecAA-00282-00078053-00078290": "install Git, maybe you want to do some other things", "iB6sHp7ecAA-00283-00078290-00078359": "configurations.", "iB6sHp7ecAA-00284-00078393-00078408": "Yep.", "iB6sHp7ecAA-00285-00078418-00078719": "Is there any other scenario you think about supporting?", "iB6sHp7ecAA-00286-00078720-00078944": "Or maybe you you plan on supporting early?", "iB6sHp7ecAA-00287-00079074-00079522": "I I think the initial use case that we're looking at is Umm,", "iB6sHp7ecAA-00288-00079522-00079948": "specifically kind of targeted at projects that are in Git", "iB6sHp7ecAA-00289-00079948-00080044": "repositories.", "iB6sHp7ecAA-00290-00080077-00080364": "So the idea is you could build one of these configurations.", "iB6sHp7ecAA-00291-00080365-00080706": "It will know about the tools and the configurations that need to", "iB6sHp7ecAA-00292-00080706-00081011": "be applied so that you can actually get your machine into", "iB6sHp7ecAA-00293-00081011-00081306": "the state you want it to be in to work on that project.", "iB6sHp7ecAA-00294-00081351-00081626": "But clearly, if you wanted to create a configuration for", "iB6sHp7ecAA-00295-00081626-00081902": "yourself where you're saying, hey, this is how I want my", "iB6sHp7ecAA-00296-00081902-00082197": "machine to be configured, you would be able to run that file", "iB6sHp7ecAA-00297-00082197-00082236": "as well.", "iB6sHp7ecAA-00298-00082237-00082608": "So if you think about back in Linux with DOT files, this would", "iB6sHp7ecAA-00299-00082608-00082979": "be kind of a similar kind of a concept where you can say, hey,", "iB6sHp7ecAA-00300-00082979-00083338": "this is how I want my machine and you run that configuration", "iB6sHp7ecAA-00301-00083338-00083697": "and any DSC resource would be something that could be pulled", "iB6sHp7ecAA-00302-00083697-00083715": "in.", "iB6sHp7ecAA-00303-00083758-00084104": "We're still working on a lot of the governance and security", "iB6sHp7ecAA-00304-00084104-00084456": "concerns that enterprises are gonna have, but you'll be able", "iB6sHp7ecAA-00305-00084456-00084825": "to go in and make things work so that you can just use whatever", "iB6sHp7ecAA-00306-00084825-00084935": "resources you want.", "iB6sHp7ecAA-00307-00084936-00085179": "PowerShell Gallery Wild West have a great time.", "iB6sHp7ecAA-00308-00085379-00085403": "Nice.", "iB6sHp7ecAA-00309-00085444-00085475": "Yeah.", "iB6sHp7ecAA-00310-00085476-00085889": "So it it will pull local if you just have a a resource that", "iB6sHp7ecAA-00311-00085488-00085504": "So.", "iB6sHp7ecAA-00312-00085889-00086254": "you've implemented locally. It's not in the gallery.", "iB6sHp7ecAA-00313-00086255-00086677": "It will use it if it's not local, it'll go to the gallery", "iB6sHp7ecAA-00314-00086677-00087041": "to try to find it, install and and carry forward.", "iB6sHp7ecAA-00315-00087042-00087633": "As long as you of course agree to the Nonfinal legal contract", "iB6sHp7ecAA-00316-00087633-00087814": "that we have there.", "iB6sHp7ecAA-00317-00088107-00088390": "So yeah, I think Daniel, did you have a question?", "iB6sHp7ecAA-00318-00088377-00088411": "Yeah.", "iB6sHp7ecAA-00319-00088412-00088484": "Do do you?", "iB6sHp7ecAA-00320-00088490-00088863": "Do you guys see this as used as as more of a desktop", "iB6sHp7ecAA-00321-00088863-00089292": "configuration tool or also on the server side where you know", "iB6sHp7ecAA-00322-00089292-00089749": "you, you know say Windows Server core, you might not have UI but", "iB6sHp7ecAA-00323-00089749-00090010": "you need a bunch of tools installed.", "iB6sHp7ecAA-00324-00090011-00090196": "Do you see that being a use case as well?", "iB6sHp7ecAA-00325-00090291-00090668": "Yeah, we've had some interesting challenges getting support on", "iB6sHp7ecAA-00326-00090668-00090788": "Windows Server SKUs.", "iB6sHp7ecAA-00327-00090861-00091115": "I think the the biggest challenge we've had is that", "iB6sHp7ecAA-00328-00091115-00091404": "typically the store is not enabled on Windows Server SKUs,", "iB6sHp7ecAA-00329-00091404-00091722": "so there's no way for us to kind of service or update ourselves.", "iB6sHp7ecAA-00330-00091819-00092231": "So that was kind of where a lot of this stuff actually sort of", "iB6sHp7ecAA-00331-00092231-00092611": "originated was we needed a mechanism that was reliable to", "iB6sHp7ecAA-00332-00092611-00093036": "get wingit onto a system and we went down the path of building a", "iB6sHp7ecAA-00333-00093036-00093194": "DSC resource to do that.", "iB6sHp7ecAA-00334-00093213-00093485": "That's some of the work that we've got and we've actually", "iB6sHp7ecAA-00335-00093485-00093777": "published that that when get CLI, but it still got some rough", "iB6sHp7ecAA-00336-00093777-00093834": "edges on it.", "iB6sHp7ecAA-00337-00093867-00094212": "But we're looking at that as a possible way to get wingit on to", "iB6sHp7ecAA-00338-00094212-00094558": "Windows Server and to be able to upgrade it from there as well.", "iB6sHp7ecAA-00339-00094599-00094897": "So that's kind of what we've been looking at for being able", "iB6sHp7ecAA-00340-00094897-00095166": "to say, hey, we can support winged on Windows Server.", "iB6sHp7ecAA-00341-00095232-00095564": "There's still some challenges with server 19 where app", "iB6sHp7ecAA-00342-00095564-00095903": "execution aliases are not available, so that poses some", "iB6sHp7ecAA-00343-00095903-00096042": "interesting challenges.", "iB6sHp7ecAA-00344-00096101-00096448": "But on server 22, largely it works.", "iB6sHp7ecAA-00345-00096449-00096686": "It's just a matter of us saying it's experimental because we", "iB6sHp7ecAA-00346-00096686-00096834": "just don't have a reliable mechanism.", "iB6sHp7ecAA-00347-00096863-00097119": "Yeah, that's publicly available for you to get when get on", "iB6sHp7ecAA-00348-00097119-00097376": "Windows Server and be able to make sure that it's working.", "iB6sHp7ecAA-00349-00097521-00097830": "My hope is that we get some mileage on the DSC resource that", "iB6sHp7ecAA-00350-00097830-00098165": "ends up proving to be a reliable way to get an update when get on", "iB6sHp7ecAA-00351-00098165-00098449": "server, and then hopefully we'll be able to change that", "iB6sHp7ecAA-00352-00098449-00098734": "positioning and say hey Yep, we're supported on server.", "iB6sHp7ecAA-00353-00098761-00099041": "Here's the approved method provided by Microsoft for doing", "iB6sHp7ecAA-00354-00099041-00099065": "that.", "iB6sHp7ecAA-00355-00099274-00099612": "I will say, as far as the configuration through DSE", "iB6sHp7ecAA-00356-00099612-00100009": "resources, as long as the DSC resource works on server, I do", "iB6sHp7ecAA-00357-00100009-00100393": "expect the configuration part to work if that makes sense.", "iB6sHp7ecAA-00358-00100440-00100485": "Yep.", "iB6sHp7ecAA-00359-00100490-00100845": "So we in in theory we should be able even without the Windows", "iB6sHp7ecAA-00360-00100845-00101172": "Store, we should be able to use this in our DSC configs.", "iB6sHp7ecAA-00361-00101323-00101664": "You know we need a if we need git installed, even if we don't", "iB6sHp7ecAA-00362-00101664-00102005": "have the store, we're still able to use this right as long as", "iB6sHp7ecAA-00363-00101912-00101926": "Yes.", "iB6sHp7ecAA-00364-00102005-00102269": "wind gets bootstrapped, I guess is the we need.", "iB6sHp7ecAA-00365-00102270-00102497": "The wouldn't get to be bootstrapped on server.", "iB6sHp7ecAA-00366-00102498-00102735": "There's wouldn't get currently gotcha, OK.", "iB6sHp7ecAA-00367-00102538-00102569": "Correct.", "iB6sHp7ecAA-00368-00102750-00102849": "That well.", "iB6sHp7ecAA-00369-00102850-00103278": "So for the configuration part, using the DSC resources that is", "iB6sHp7ecAA-00370-00103278-00103646": "just gonna be a module standalone, no wingit specific", "iB6sHp7ecAA-00371-00103646-00103721": "dependency.", "iB6sHp7ecAA-00372-00103788-00104152": "You could then use that to bootstrap wingit via the", "iB6sHp7ecAA-00373-00104152-00104615": "resources that we're building to then provide that uh, capability", "iB6sHp7ecAA-00374-00104357-00104458": "Yep. Gotcha.", "iB6sHp7ecAA-00375-00104615-00104860": "to use those winged DSC resources.", "iB6sHp7ecAA-00376-00104861-00105201": "But you could use arbitrarily other DSE resources as well.", "iB6sHp7ecAA-00377-00105248-00105289": "Yep.", "iB6sHp7ecAA-00378-00105294-00105575": "And if you already had an investment in Chakka were scoop", "iB6sHp7ecAA-00379-00105575-00105842": "or something else where expecting those resources will", "iB6sHp7ecAA-00380-00105842-00105983": "be able to work just as well.", "iB6sHp7ecAA-00381-00106008-00106342": "So this is not about hey, we're chef and winget down your", "iB6sHp7ecAA-00382-00106342-00106383": "throat.", "iB6sHp7ecAA-00383-00106383-00106584": "You have to use win get to install and manage things.", "iB6sHp7ecAA-00384-00106585-00106845": "If you've already got some resources that work and do what", "iB6sHp7ecAA-00385-00106845-00107104": "you need them to do, we just want to be able to extend and", "iB6sHp7ecAA-00386-00107104-00107161": "embrace that.", "iB6sHp7ecAA-00387-00107318-00107347": "Awesome.", "iB6sHp7ecAA-00388-00107399-00107698": "And I and I think from kind of early discussions where we've", "iB6sHp7ecAA-00389-00107698-00107988": "started looking at things we've run into all kinds of fun.", "iB6sHp7ecAA-00390-00107989-00108329": "So for example, building that configuration for power toys,", "iB6sHp7ecAA-00391-00108329-00108704": "they leverage the WIX installer, and right now we don't allow Wix", "iB6sHp7ecAA-00392-00108704-00109062": "into the community repository because it won't install without", "iB6sHp7ecAA-00393-00109062-00109135": "dependencies.", "iB6sHp7ecAA-00394-00109169-00109482": "So we've actually got an engineer that's doing some work", "iB6sHp7ecAA-00395-00109482-00109784": "through our experimental dependency feature to turn on", "iB6sHp7ecAA-00396-00109784-00110125": "Windows features so that we can get the NET Framework enabled", "iB6sHp7ecAA-00397-00110125-00110471": "and then we'll add Wix as a sort of reference package for that", "iB6sHp7ecAA-00398-00110471-00110801": "mechanism and hopefully that will unblock us so that we can", "iB6sHp7ecAA-00399-00110801-00111136": "actually build a configuration that will do all of the magic", "iB6sHp7ecAA-00400-00111136-00111466": "necessary so that you could actually run the configuration,", "iB6sHp7ecAA-00401-00111466-00111801": "launch Visual Studio and then hit F5 to build power toys and", "iB6sHp7ecAA-00402-00111801-00112136": "then we'll start working on some of the other projects under", "iB6sHp7ecAA-00403-00112136-00112482": "Microsoft and hopefully we'll get some support with other open", "iB6sHp7ecAA-00404-00112482-00112784": "source projects where we'll build some configurations.", "iB6sHp7ecAA-00405-00112785-00113053": "And test them and open, NPRS, and hopefully they'll be willing", "iB6sHp7ecAA-00406-00113053-00113113": "to adopt that.", "iB6sHp7ecAA-00407-00113201-00113526": "I think we'll be building a handful of DSC resources that", "iB6sHp7ecAA-00408-00113526-00113862": "sort of don't exist that are needed, and my hope is that we", "iB6sHp7ecAA-00409-00113862-00114115": "can do that open source under DSC community.", "iB6sHp7ecAA-00410-00114156-00114441": "You know, we'll certainly contribute the, you know, the", "iB6sHp7ecAA-00411-00114441-00114773": "initial proof of concept or hack together version of it and then", "iB6sHp7ecAA-00412-00114773-00115089": "hopefully the community will start seeing the value and we'll", "iB6sHp7ecAA-00413-00115089-00115405": "get more attraction to building and maintaining DSC resources", "iB6sHp7ecAA-00414-00115405-00115675": "and really help grow this community rather than just", "iB6sHp7ecAA-00415-00115675-00115935": "trying to reinvent the wheel or go somewhere else.", "iB6sHp7ecAA-00416-00116147-00116183": "Awesome.", "iB6sHp7ecAA-00417-00116183-00116290": "That sounds fantastic.", "iB6sHp7ecAA-00418-00116299-00116348": "So.", "iB6sHp7ecAA-00419-00116363-00116418": "So what?", "iB6sHp7ecAA-00420-00116419-00116667": "What's the time frame you your, your team is looking?", "iB6sHp7ecAA-00421-00116668-00116955": "Because I I see this, you mentioned the PR's coming", "iB6sHp7ecAA-00422-00116955-00117000": "through.", "iB6sHp7ecAA-00423-00117001-00117441": "Are they coming through in the next set of month or so to the", "iB6sHp7ecAA-00424-00117409-00117543": "Yeah, I think we'll have.", "iB6sHp7ecAA-00425-00117441-00117541": "wind gets CLI?", "iB6sHp7ecAA-00426-00117583-00117890": "Yeah, I think we'll have something that you can sort of", "iB6sHp7ecAA-00427-00117890-00118240": "use as a as a self host example from the open source repository", "iB6sHp7ecAA-00428-00118240-00118590": "probably next month or so, we'll have our next release out once", "iB6sHp7ecAA-00429-00118590-00118919": "we've knocked the obvious bugs off of the golden path here.", "iB6sHp7ecAA-00430-00118945-00119242": "And I think it'll probably stay as an experimental feature in", "iB6sHp7ecAA-00431-00119242-00119377": "wingit for the next release.", "iB6sHp7ecAA-00432-00119378-00119657": "That's probably April, May timeframe.", "iB6sHp7ecAA-00433-00119703-00120104": "And then after we get sort of more of that community feedback,", "iB6sHp7ecAA-00434-00120104-00120468": "we lock on a more reliable schema with the configuration", "iB6sHp7ecAA-00435-00120468-00120806": "format and we're partnering with PowerShell on that.", "iB6sHp7ecAA-00436-00120848-00121148": "We'll start seeing more of this becoming broadly available and", "iB6sHp7ecAA-00437-00121148-00121444": "we'll hopefully start seeing more people looking to adopt the", "iB6sHp7ecAA-00438-00121444-00121497": "technology.", "iB6sHp7ecAA-00439-00121703-00121768": "Fantastic.", "iB6sHp7ecAA-00440-00121769-00121859": "What else do you need?", "iB6sHp7ecAA-00441-00121860-00121978": "Any help from the community?", "iB6sHp7ecAA-00442-00121979-00122018": "What else?", "iB6sHp7ecAA-00443-00122019-00122307": "What can people do if they want to get involved or support or", "iB6sHp7ecAA-00444-00122307-00122405": "try it out? Etcetera.", "iB6sHp7ecAA-00445-00122470-00122913": "As soon as we have a release out there, I'll be looking for help", "iB6sHp7ecAA-00446-00122913-00123302": "on sort of guidance and documentation, best practices on", "iB6sHp7ecAA-00447-00123302-00123664": "building resources, how to contribute to that stuff.", "iB6sHp7ecAA-00448-00123665-00123908": "Like when I go look at Microsoft Docs today.", "iB6sHp7ecAA-00449-00123909-00124239": "Honestly, if you know what DSC is and how to build it, they're", "iB6sHp7ecAA-00450-00124239-00124271": "great.", "iB6sHp7ecAA-00451-00124332-00124643": "But if you've never seen anything like this before, it's", "iB6sHp7ecAA-00452-00124643-00124775": "a very daunting process.", "iB6sHp7ecAA-00453-00124814-00125067": "So I really want to make sure we've got some solid", "iB6sHp7ecAA-00454-00125067-00125356": "documentation on you know, hey, you heard about this cool", "iB6sHp7ecAA-00455-00125356-00125391": "wingit.", "iB6sHp7ecAA-00456-00125392-00125459": "Configure thing.", "iB6sHp7ecAA-00457-00125460-00125535": "How do you get started?", "iB6sHp7ecAA-00458-00125636-00125942": "I think there's gonna be a lot of discoverability challenges", "iB6sHp7ecAA-00459-00125942-00125978": "around.", "iB6sHp7ecAA-00460-00126032-00126562": "Umm, you know, does a particular resource map to some specific", "iB6sHp7ecAA-00461-00126562-00126899": "package ID in WINGIT or Choco or SCOOP.", "iB6sHp7ecAA-00462-00126906-00127285": "So I think there's gonna be some opportunity to try to figure out", "iB6sHp7ecAA-00463-00127285-00127629": "how we enrich the metadata so that it's easier for somebody", "iB6sHp7ecAA-00464-00127629-00127968": "that knows what they want to install to find the resources", "iB6sHp7ecAA-00465-00127968-00128101": "that will configure it.", "iB6sHp7ecAA-00466-00128143-00128489": "And I think it's very much from my point of view, we're happy", "iB6sHp7ecAA-00467-00128489-00128842": "that we're open source and to help track issues and cross Lync", "iB6sHp7ecAA-00468-00128842-00129183": "things you know, and I and I think it'll be a process, we'll", "iB6sHp7ecAA-00469-00129183-00129485": "probably wanna create a repository somewhere where we", "iB6sHp7ecAA-00470-00129485-00129832": "can just kind of track issues where people are saying, hey, I", "iB6sHp7ecAA-00471-00129832-00130162": "need to be able to configure this thing and I could really", "iB6sHp7ecAA-00472-00130162-00130431": "use some help finding or building the resource.", "iB6sHp7ecAA-00473-00130801-00130846": "Awesome.", "iB6sHp7ecAA-00474-00130851-00131124": "And you mentioned documentation, Mikey courses.", "iB6sHp7ecAA-00475-00131203-00131478": "I wonder if Mikey, you're you're working on this?", "iB6sHp7ecAA-00476-00131479-00131541": "So you this.", "iB6sHp7ecAA-00477-00131945-00132020": "You're muted, Mike.", "iB6sHp7ecAA-00478-00132066-00132550": "Yeah, I took myself off mute right after I said a this is so", "iB6sHp7ecAA-00479-00132550-00132852": "yeah, you can always reach out to me.", "iB6sHp7ecAA-00480-00132723-00132810": "Trump, Mikey in it.", "iB6sHp7ecAA-00481-00132967-00133332": "So I had been focused on retooling the V2 DSC docs is", "iB6sHp7ecAA-00482-00133332-00133765": "where a lot of my attention has been the last couple of months,", "iB6sHp7ecAA-00483-00133765-00134192": "actually working on a doc right now for machine configuration.", "iB6sHp7ecAA-00484-00134401-00134796": "But if there's, if you have suggestions, ideas, thoughts,", "iB6sHp7ecAA-00485-00134796-00135184": "concerns, particularly stuff that doesn't work is rough.", "iB6sHp7ecAA-00486-00135185-00135725": "Whatever I need you to tell me when those things pop up.", "iB6sHp7ecAA-00487-00135732-00136157": "Right, because prior to this, I also spent five years writing", "iB6sHp7ecAA-00488-00136157-00136459": "the equivalent of DSC resources for Puppet.", "iB6sHp7ecAA-00489-00136495-00136898": "My brain is extremely tuned in to CM uh and it is extremely", "iB6sHp7ecAA-00490-00136898-00137316": "hard for me to put myself back in the I have no idea what any", "iB6sHp7ecAA-00491-00137316-00137390": "of this is.", "iB6sHp7ecAA-00492-00137395-00137544": "Lens, right?", "iB6sHp7ecAA-00493-00137624-00137900": "So my focus recently has been cause some people who are using", "iB6sHp7ecAA-00494-00137900-00138172": "V2, broadly speaking, are people who are coming from machine", "iB6sHp7ecAA-00495-00138172-00138435": "config, in which case they figured out what they wanted to", "iB6sHp7ecAA-00496-00138435-00138449": "do.", "iB6sHp7ecAA-00497-00138456-00138717": "Going through that route, or people who are looking to", "iB6sHp7ecAA-00498-00138717-00138803": "upgrade from V-11.", "iB6sHp7ecAA-00499-00138826-00139136": "So my focus has really been on authoring resources and cleaning", "iB6sHp7ecAA-00500-00139136-00139175": "that up.", "iB6sHp7ecAA-00501-00139176-00139518": "I think those docs are better now than they used to be, but I", "iB6sHp7ecAA-00502-00139518-00139579": "wrote them.", "iB6sHp7ecAA-00503-00139580-00139642": "So what do I know?", "iB6sHp7ecAA-00504-00139725-00139932": "Uh, I am.", "iB6sHp7ecAA-00505-00139925-00139990": "The great monkey.", "iB6sHp7ecAA-00506-00139933-00140454": "I am not a neutral observer, but seriously, if there's stuff that", "iB6sHp7ecAA-00507-00140454-00140881": "you think, hey, we need to document on, you know this", "iB6sHp7ecAA-00508-00140881-00141340": "particular topic or you know what is CMYCM, I'm extremely", "iB6sHp7ecAA-00509-00141340-00141798": "happy to put those in the backlog and to start working on", "iB6sHp7ecAA-00510-00141798-00141838": "them.", "iB6sHp7ecAA-00511-00142119-00142442": "I am super duper interested in the work that's happening over", "iB6sHp7ecAA-00512-00142442-00142619": "on the Wingate side of the House.", "iB6sHp7ecAA-00513-00142620-00142953": "For this I've been very excited and it's been hard to keep my", "iB6sHp7ecAA-00514-00142953-00143012": "mouth shut.", "iB6sHp7ecAA-00515-00143041-00143057": "Yeah.", "iB6sHp7ecAA-00516-00143057-00143283": "So I'm stoked to see a public preview.", "iB6sHp7ecAA-00517-00143403-00143440": "Yeah.", "iB6sHp7ecAA-00518-00143441-00143770": "We're we're pretty excited about it and I haven't really updated", "iB6sHp7ecAA-00519-00143770-00144084": "the the widget road map yet at some point I'll probably go in", "iB6sHp7ecAA-00520-00144084-00144312": "and and mark this as a strategic investment.", "iB6sHp7ecAA-00521-00144313-00144564": "If we start seeing people showing some real interest here", "iB6sHp7ecAA-00522-00144564-00144833": "to help kind of prioritize some of this work over some of the", "iB6sHp7ecAA-00523-00144833-00144964": "other things that we're doing.", "iB6sHp7ecAA-00524-00145009-00145437": "But right now it's been sort of exploratory and proof of concept", "iB6sHp7ecAA-00525-00145437-00145510": "type stuff.", "iB6sHp7ecAA-00526-00145511-00145902": "And wow, there's already kind of a configuration management", "iB6sHp7ecAA-00527-00145902-00146020": "solution in place.", "iB6sHp7ecAA-00528-00146069-00146280": "Let's see if we can make this work on the client.", "iB6sHp7ecAA-00529-00146301-00146475": "Let's see if we can make winget work on server.", "iB6sHp7ecAA-00530-00146540-00146835": "Let's work with PowerShell team and really you know, enrich that", "iB6sHp7ecAA-00531-00146835-00146885": "investment.", "iB6sHp7ecAA-00532-00146904-00147251": "And you know, we're hoping that this is gonna help influence", "iB6sHp7ecAA-00533-00147251-00147457": "some of the direction that B3 goes.", "iB6sHp7ecAA-00534-00147492-00147849": "And ultimately, I think this configuration schema really", "iB6sHp7ecAA-00535-00147849-00148194": "should be a PowerShell V3 type of a schema so that the", "iB6sHp7ecAA-00536-00148194-00148539": "PowerShell team is really driving it and it's not just", "iB6sHp7ecAA-00537-00148539-00148891": "limited to wingit is the only thing that can run these.", "iB6sHp7ecAA-00538-00148916-00149351": "It really needs to be however you want to leverage DSC.", "iB6sHp7ecAA-00539-00149374-00149574": "You should be able to get the benefits out of all of this.", "iB6sHp7ecAA-00540-00149835-00149870": "Nice.", "iB6sHp7ecAA-00541-00149877-00149915": "Awesome.", "iB6sHp7ecAA-00542-00149987-00150348": "So we should get you guys back in a in a couple of months right", "iB6sHp7ecAA-00543-00150348-00150697": "now and you to get you to share an update and take us through", "iB6sHp7ecAA-00544-00150697-00150929": "where you're at and what we can do next.", "iB6sHp7ecAA-00545-00150981-00151056": "Absolutely.", "iB6sHp7ecAA-00546-00151063-00151284": "And I've been talking with uh.", "iB6sHp7ecAA-00547-00151542-00152088": "I'm going blank now, Jason, about doing something at the", "iB6sHp7ecAA-00548-00152088-00152587": "upcoming North America Conq and my My personal CFO.", "iB6sHp7ecAA-00549-00152588-00153087": "My wife has agreed to let me go to EU, so we're working on dates", "iB6sHp7ecAA-00550-00153087-00153371": "and getting ready to book that trip.", "iB6sHp7ecAA-00551-00153372-00153609": "It's gonna be on my own dime because of budget stuff.", "iB6sHp7ecAA-00552-00153610-00153938": "So I'm gonna call it a week vacation in Prague and I'll just", "iB6sHp7ecAA-00553-00153938-00154271": "be speaking at the conference and embarrassing everybody with", "iB6sHp7ecAA-00554-00154271-00154444": "my lack of PowerShell knowledge.", "iB6sHp7ecAA-00555-00154519-00154637": "So I'm looking forward to it.", "iB6sHp7ecAA-00556-00154740-00154884": "That sounds awesome. Fantastic.", "iB6sHp7ecAA-00557-00154868-00154907": "Amazing.", "iB6sHp7ecAA-00558-00155249-00155287": "Kelsey.", "iB6sHp7ecAA-00559-00155254-00155291": "Perfect.", "iB6sHp7ecAA-00560-00155419-00155871": "So yeah, I mean any, any, any other things you wanna share and", "iB6sHp7ecAA-00561-00155871-00156323": "otherwise sounds like you guys have almost you know we're very", "iB6sHp7ecAA-00562-00156323-00156589": "excited to see where things go next.", "iB6sHp7ecAA-00563-00156651-00156954": "Uh, and I think we're right on time for you to make your next", "iB6sHp7ecAA-00564-00156954-00156994": "meeting.", "iB6sHp7ecAA-00565-00157102-00157147": "Perfect.", "iB6sHp7ecAA-00566-00157148-00157213": "Appreciate it.", "iB6sHp7ecAA-00567-00157324-00157639": "If if people are, if people have questions, where can they reach", "iB6sHp7ecAA-00568-00157349-00157383": "Awesome.", "iB6sHp7ecAA-00569-00157639-00157693": "out to you?", "iB6sHp7ecAA-00570-00157724-00157783": "Can you drop?", "iB6sHp7ecAA-00571-00157751-00158065": "Umm you you can ping me on Twitter.", "iB6sHp7ecAA-00572-00157784-00157879": "Maybe your contacts?", "iB6sHp7ecAA-00573-00158066-00158159": "You can email me.", "iB6sHp7ecAA-00574-00158160-00158355": "I'll put all my stuff in the chat here.", "iB6sHp7ecAA-00575-00158555-00159065": "Super Fantastic and and thanks John as well for for for sharing", "iB6sHp7ecAA-00576-00158581-00158610": "Awesome.", "iB6sHp7ecAA-00577-00159065-00159289": "the the YOUR Code your demo.", "iB6sHp7ecAA-00578-00159290-00159552": "I'm sure everyone wants to jump straight in.", "iB6sHp7ecAA-00579-00159655-00159890": "Umm and and start messing around with it.", "iB6sHp7ecAA-00580-00159891-00159977": "So fantastic.", "iB6sHp7ecAA-00581-00160081-00160134": "Yeah.", "iB6sHp7ecAA-00582-00160135-00160273": "For for John. And what?", "iB6sHp7ecAA-00583-00160279-00160537": "And demitrius, if you have any question if you want to know", "iB6sHp7ecAA-00584-00160537-00160788": "things about the Community, feel free to reach out to us.", "iB6sHp7ecAA-00585-00160789-00161239": "We meet every six weeks and otherwise everyone here, many", "iB6sHp7ecAA-00586-00161239-00161666": "people here are usually also on the PowerShell like or", "iB6sHp7ecAA-00587-00161666-00161830": "PowerShell disk code.", "iB6sHp7ecAA-00588-00161840-00162158": "There's a DSC channel where we hang out and then you can ask", "iB6sHp7ecAA-00589-00162158-00162482": "questions and you should get answers pretty quickly in there.", "iB6sHp7ecAA-00590-00162555-00162646": "Fantastic.", "iB6sHp7ecAA-00591-00162667-00162960": "I think I think my biggest ask is gonna be kind of around some", "iB6sHp7ecAA-00592-00162960-00163086": "of the documentation stuff.", "iB6sHp7ecAA-00593-00163095-00163452": "I really wanna make sure we get things really crisply kind of", "iB6sHp7ecAA-00594-00163452-00163810": "broken down into the different areas and take the approach of", "iB6sHp7ecAA-00595-00163810-00164058": "somebody's never seen or done this before.", "iB6sHp7ecAA-00596-00164059-00164144": "How do we hold their hand?", "iB6sHp7ecAA-00597-00164210-00164569": "Umm, so a lot of what I'm doing internally, I'll call it dog", "iB6sHp7ecAA-00598-00164569-00164617": "fooding.", "iB6sHp7ecAA-00599-00164618-00164765": "I've got kind of an internal wiki.", "iB6sHp7ecAA-00600-00164808-00165165": "I'm reaching out to some other teams once we have this out at", "iB6sHp7ecAA-00601-00165165-00165482": "when Git CLI and we've got the 0.1 JSON schema for the", "iB6sHp7ecAA-00602-00165482-00165863": "configuration and what I plan on doing is just asking other teams", "iB6sHp7ecAA-00603-00165863-00166025": "hey build the configuration.", "iB6sHp7ecAA-00604-00166026-00166354": "We're not gonna help you use the docs if you can't figure it out,", "iB6sHp7ecAA-00605-00166354-00166683": "then we need to fix the Docs and then as we do those improvements", "iB6sHp7ecAA-00606-00166683-00166877": "we'll we'll go through the next teams.", "iB6sHp7ecAA-00607-00166878-00167179": "We're working with our documentation person and we'll", "iB6sHp7ecAA-00608-00167179-00167524": "definitely work with Mikey on this as well so that we kind of", "iB6sHp7ecAA-00609-00167524-00167881": "cover all the bases everywhere and the hope is that by the time", "iB6sHp7ecAA-00610-00167881-00168215": "this stuff goes out, sort of more GA, it's a no brainer and", "iB6sHp7ecAA-00611-00168215-00168561": "you've got all the guidance that you need, regardless of what", "iB6sHp7ecAA-00612-00168561-00168896": "your current technology and skill sets and backgrounds are.", "iB6sHp7ecAA-00613-00169177-00169211": "Perfect.", "iB6sHp7ecAA-00614-00169188-00169224": "Awesome.", "iB6sHp7ecAA-00615-00169311-00169562": "So I've gotta drop off and join my next meeting, but feel free", "iB6sHp7ecAA-00616-00169562-00169746": "to reach out if you have any other questions.", "iB6sHp7ecAA-00617-00169747-00170017": "And I would say generally speaking, just interact at", "iB6sHp7ecAA-00618-00170017-00170329": "GitHub that keeps everything open source and keeps everybody", "iB6sHp7ecAA-00619-00170329-00170370": "engaged.", "iB6sHp7ecAA-00620-00170580-00170653": "Fantastic.", "iB6sHp7ecAA-00621-00170639-00170726": "What we'll do.", "iB6sHp7ecAA-00622-00170664-00170692": "Awesome.", "iB6sHp7ecAA-00623-00170815-00170891": "Thank you.", "iB6sHp7ecAA-00624-00170896-00170924": "OK.", "iB6sHp7ecAA-00625-00170925-00170970": "Should we?", "iB6sHp7ecAA-00626-00170971-00171387": "Jodi, you're about do you wanna do you wanna jump on in and and", "iB6sHp7ecAA-00627-00171387-00171452": "give us a?", "iB6sHp7ecAA-00628-00171458-00171654": "Yeah, bit of an update.", "iB6sHp7ecAA-00629-00171900-00171987": "Yeah, totally.", "iB6sHp7ecAA-00630-00171988-00172344": "So just a couple of updates from our end that are mainly around", "iB6sHp7ecAA-00631-00172344-00172646": "the new module release and the new extension release.", "iB6sHp7ecAA-00632-00172734-00173204": "So newest version of our agent is 1.2948 and with this you can", "iB6sHp7ecAA-00633-00173204-00173681": "now you can now leverage built in Windows PowerShell modules as", "iB6sHp7ecAA-00634-00173681-00174143": "well as Community resources that are not necessarily imported", "iB6sHp7ecAA-00635-00174143-00174308": "into into your config.", "iB6sHp7ecAA-00636-00174326-00174642": "So a big win here is gonna be able to use Windows feature and", "iB6sHp7ecAA-00637-00174642-00174968": "we're really excited because we know that this has been a a gap", "iB6sHp7ecAA-00638-00174968-00175274": "for a DS users for for quite a while on machine config too.", "iB6sHp7ecAA-00639-00175440-00175653": "With this latest extension release also we now support.", "iB6sHp7ecAA-00640-00175788-00175991": "Additional parameter types in addition to strings.", "iB6sHp7ecAA-00641-00175992-00176397": "So now you can leverage strings, integers, booleans and doubles,", "iB6sHp7ecAA-00642-00176397-00176790": "and all that's required is the latest extension version, which", "iB6sHp7ecAA-00643-00176790-00177165": "again I'll put in the chat as 1.2948 and then the latest GC", "iB6sHp7ecAA-00644-00177165-00177290": "module which is 4.3.", "iB6sHp7ecAA-00645-00177386-00177677": "So with that, we've got some really great examples that are", "iB6sHp7ecAA-00646-00177677-00177910": "going to be coming out in the next month or so.", "iB6sHp7ecAA-00647-00177915-00178279": "Ohh to arc box and in the arc jumpstart guides I'm not sure if", "iB6sHp7ecAA-00648-00178279-00178625": "folks here have have tried out arc box before, but a lot of", "iB6sHp7ecAA-00649-00178625-00178955": "really great resources around hybrid enablement and some", "iB6sHp7ecAA-00650-00178955-00179267": "commonly used management scenarios for Archer two, so", "iB6sHp7ecAA-00651-00179267-00179475": "I'll drop that in the chat as well.", "iB6sHp7ecAA-00652-00179499-00179861": "And we also got Julia on the call, who is working closely on", "iB6sHp7ecAA-00653-00179861-00179891": "this.", "iB6sHp7ecAA-00654-00179892-00180247": "So either of us would be happy to sort of hear your feedback or", "iB6sHp7ecAA-00655-00180247-00180563": "any additional scenarios that you might be interested in", "iB6sHp7ecAA-00656-00180563-00180735": "interested in seeing live once.", "iB6sHp7ecAA-00657-00180740-00180882": "Once this becomes available.", "iB6sHp7ecAA-00658-00180911-00181208": "So yeah, just short and sweet, but also always happy to answer", "iB6sHp7ecAA-00659-00181208-00181435": "any questions that you have after the call too.", "iB6sHp7ecAA-00660-00181582-00181659": "Fantastic.", "iB6sHp7ecAA-00661-00181708-00181755": "Hey, what?", "iB6sHp7ecAA-00662-00181720-00181915": "I I think you're good.", "iB6sHp7ecAA-00663-00181756-00181801": "Just quit.", "iB6sHp7ecAA-00664-00181875-00181923": "Go and get.", "iB6sHp7ecAA-00665-00181975-00182021": "Yeah, yeah, yeah.", "iB6sHp7ecAA-00666-00182082-00182434": "I just wanted to say, nor is it's very short this time, but", "iB6sHp7ecAA-00667-00182434-00182781": "probably you can come back next in six weeks and then do a", "iB6sHp7ecAA-00668-00182781-00183017": "presentation on maybe demo all of this.", "iB6sHp7ecAA-00669-00183052-00183120": "That would be fun.", "iB6sHp7ecAA-00670-00183065-00183166": "Yeah, I love it.", "iB6sHp7ecAA-00671-00183201-00183235": "Love it.", "iB6sHp7ecAA-00672-00183364-00183559": "I I was just querying Jody.", "iB6sHp7ecAA-00673-00183394-00183433": "There you go.", "iB6sHp7ecAA-00674-00183560-00183866": "What can you run through a bit of a summary of a Xbox?", "iB6sHp7ecAA-00675-00184041-00184142": "Yeah, absolutely.", "iB6sHp7ecAA-00676-00184143-00184499": "So I can see if I can share my screen.", "iB6sHp7ecAA-00677-00184561-00184633": "Ah, even better.", "iB6sHp7ecAA-00678-00184634-00184813": "I mean, well of it is screen sharing.", "iB6sHp7ecAA-00679-00184900-00185012": "Let's see once again.", "iB6sHp7ecAA-00680-00185090-00185149": "To PowerPoint.", "iB6sHp7ecAA-00681-00186327-00186343": "Cool.", "iB6sHp7ecAA-00682-00186818-00186988": "Infection my screen OK.", "iB6sHp7ecAA-00683-00187142-00187172": "Yep.", "iB6sHp7ecAA-00684-00187162-00187265": "OK, awesome.", "iB6sHp7ecAA-00685-00187300-00187672": "So the Azure jumpstart is intended to kind of provide as", "iB6sHp7ecAA-00686-00187672-00187940": "it says here, a zero to hero experience.", "iB6sHp7ecAA-00687-00187941-00188333": "You can start working with Azure Arc, so this includes both", "iB6sHp7ecAA-00688-00188333-00188739": "examples and guidance and FAQs around Azure Arc for HCI Azure", "iB6sHp7ecAA-00689-00188739-00189111": "Arc for servers, arc for Kubernetes and it kind of comes", "iB6sHp7ecAA-00690-00189111-00189236": "in various flavors.", "iB6sHp7ecAA-00691-00189298-00189719": "So what we do is try to provide as many architecture diagrams as", "iB6sHp7ecAA-00692-00189719-00190043": "we can, as well as some common use cases for why.", "iB6sHp7ecAA-00693-00190076-00190426": "If you were an IT pro versus DevOps versus data OPS, kind of", "iB6sHp7ecAA-00694-00190426-00190771": "all the different flavors for work that are available, Umm.", "iB6sHp7ecAA-00695-00190773-00191098": "And we know that a big driver for a lot of folks connecting", "iB6sHp7ecAA-00696-00191098-00191434": "via our enabled servers is to be able to leverage some of the", "iB6sHp7ecAA-00697-00191434-00191684": "best practices from their on Prem management.", "iB6sHp7ecAA-00698-00191689-00191982": "And we know that one of those scenarios is is DSC and there's", "iB6sHp7ecAA-00699-00191982-00192120": "a content gap here right now.", "iB6sHp7ecAA-00700-00192121-00192509": "So that's one of the things that we're working on working on", "iB6sHp7ecAA-00701-00192509-00192916": "filling and what you can do is interact with the page on GitHub", "iB6sHp7ecAA-00702-00192916-00193298": "and we've got a pretty active team right now of maintainers", "iB6sHp7ecAA-00703-00193298-00193705": "who are more than happy to take any of this feedback and all of", "iB6sHp7ecAA-00704-00193705-00194119": "the code and and templates that are used for deployment for each", "iB6sHp7ecAA-00705-00194119-00194342": "of these scenarios and operations.", "iB6sHp7ecAA-00706-00194343-00194695": "Those are all those are all available on the Git through the", "iB6sHp7ecAA-00707-00194695-00194851": "open source commitment too.", "iB6sHp7ecAA-00708-00194855-00195226": "So that is a short summary, and if there's anything missing here", "iB6sHp7ecAA-00709-00195226-00195575": "that you think I can't believe this is not on the jumpstart,", "iB6sHp7ecAA-00710-00195575-00195913": "this is a really great time to to have that opinion heard.", "iB6sHp7ecAA-00711-00195920-00196020": "So yeah, just let us know.", "iB6sHp7ecAA-00712-00196013-00196056": "Awesome.", "iB6sHp7ecAA-00713-00196095-00196302": "We can agree on reach out to you, Jody.", "iB6sHp7ecAA-00714-00196444-00196843": "Yeah, bus is probably over email or Twitter.", "iB6sHp7ecAA-00715-00196848-00196955": "I'll put both of those in the chat.", "iB6sHp7ecAA-00716-00197108-00197454": "Putting the jump start here and I'll put the latest version", "iB6sHp7ecAA-00717-00197454-00197794": "release of our region in the chat too so that everyone can", "iB6sHp7ecAA-00718-00197794-00197944": "make sure they're updated.", "iB6sHp7ecAA-00719-00198221-00198262": "Awesome.", "iB6sHp7ecAA-00720-00198299-00198361": "That's fantastic.", "iB6sHp7ecAA-00721-00198362-00198697": "So people can also potentially raise issues just straight over", "iB6sHp7ecAA-00722-00198697-00199000": "in the in the GitHub it looks like, yeah, yeah, awesome.", "iB6sHp7ecAA-00723-00198804-00198970": "Yeah, exactly. Yeah.", "iB6sHp7ecAA-00724-00199249-00199370": "That's fantastic.", "iB6sHp7ecAA-00725-00199371-00199418": "So we.", "iB6sHp7ecAA-00726-00199419-00199720": "So you gonna come back in six weeks and and do some demos?", "iB6sHp7ecAA-00727-00199721-00200182": "That is that we locking that in GAIL with six week, is it six", "iB6sHp7ecAA-00728-00200182-00200651": "weeks, is that that's been the next community callers, Jillian", "iB6sHp7ecAA-00729-00200281-00200416": "She said yes, Sir.", "iB6sHp7ecAA-00730-00200430-00200467": "Here we go.", "iB6sHp7ecAA-00731-00200609-00200623": "Yeah.", "iB6sHp7ecAA-00732-00200651-00200852": "and Jody, you're locked in.", "iB6sHp7ecAA-00733-00200922-00200995": "Yeah, love it.", "iB6sHp7ecAA-00734-00200996-00201104": "This is recorded, so we're in.", "iB6sHp7ecAA-00735-00201206-00201402": "Well, there we go, committed.", "iB6sHp7ecAA-00736-00201228-00201273": "There you go.", "iB6sHp7ecAA-00737-00201515-00201726": "Julia had no saying that, but you know.", "iB6sHp7ecAA-00738-00201681-00201698": "That.", "iB6sHp7ecAA-00739-00201919-00202039": "Come off mute now and then.", "iB6sHp7ecAA-00740-00201931-00202099": "It sure sounds good.", "iB6sHp7ecAA-00741-00202066-00202103": "No.", "iB6sHp7ecAA-00742-00202184-00202199": "Yeah.", "iB6sHp7ecAA-00743-00202200-00202239": "There we go.", "iB6sHp7ecAA-00744-00202240-00202532": "We've got double commitments, so fantastic that is cool.", "iB6sHp7ecAA-00745-00202401-00202478": "Yeah, love it.", "iB6sHp7ecAA-00746-00202659-00202734": "Very exciting.", "iB6sHp7ecAA-00747-00202751-00202972": "Any questions or or from the community?", "iB6sHp7ecAA-00748-00202973-00203394": "Anyone wanna come from you and and offer a pinion question.", "iB6sHp7ecAA-00749-00203403-00203521": "So the so Ryan on there?", "iB6sHp7ecAA-00750-00203459-00203477": "So.", "iB6sHp7ecAA-00751-00203738-00203764": "Hello.", "iB6sHp7ecAA-00752-00204114-00204467": "And if if you have questions about what Demitrius said, maybe", "iB6sHp7ecAA-00753-00204467-00204599": "we can answer the like.", "iB6sHp7ecAA-00754-00204608-00205023": "Whatever we know about, which is not much, but we can try.", "iB6sHp7ecAA-00755-00205023-00205243": "Otherwise, we can relate the question and then get the answer", "iB6sHp7ecAA-00756-00205243-00205265": "later.", "iB6sHp7ecAA-00757-00205426-00205765": "So very open questions, because we've got a we've got time or", "iB6sHp7ecAA-00758-00205765-00206104": "maybe even questions not related to what you've heard so far.", "iB6sHp7ecAA-00759-00206723-00206778": "Are you?", "iB6sHp7ecAA-00760-00206779-00207026": "Where do we get the DSC hoodies exactly?", "iB6sHp7ecAA-00761-00207175-00207394": "GAIL, where we're gonna get those.", "iB6sHp7ecAA-00762-00207444-00207772": "You have to be lucky and usually if you come to Pierce, confirm", "iB6sHp7ecAA-00763-00207772-00207992": "it's the last time PS configure had a few.", "iB6sHp7ecAA-00764-00208000-00208551": "I think Jody got one and Michael had one as well and whoever was", "iB6sHp7ecAA-00765-00208551-00208967": "around at that time, I can't do another edition.", "iB6sHp7ecAA-00766-00208967-00209098": "If you come to Pierce config.", "iB6sHp7ecAA-00767-00209326-00209396": "There we hear that.", "iB6sHp7ecAA-00768-00209398-00209612": "Everyone, anyone going to PS config get one is that?", "iB6sHp7ecAA-00769-00209613-00209687": "Is that what is that?", "iB6sHp7ecAA-00770-00209688-00209758": "Is that the message?", "iB6sHp7ecAA-00771-00209885-00209977": "Anyone in there?", "iB6sHp7ecAA-00772-00209978-00210038": "Probably, yeah.", "iB6sHp7ecAA-00773-00210098-00210131": "Yeah.", "iB6sHp7ecAA-00774-00210138-00210201": "There we go.", "iB6sHp7ecAA-00775-00210296-00210325": "Cool.", "iB6sHp7ecAA-00776-00210429-00210540": "What do we wanna?", "iB6sHp7ecAA-00777-00210541-00210716": "It sounds like we've got nothing else to cover.", "iB6sHp7ecAA-00778-00210717-00210864": "Do we wanna turn the recording off?", "iB6sHp7ecAA-00779-00210865-00211091": "And maybe anyone can stick around, ask some additional", "iB6sHp7ecAA-00780-00211091-00211236": "questions you don't want recorded.", "iB6sHp7ecAA-00781-00211237-00211507": "Perhaps you know we you never know.", "iB6sHp7ecAA-00782-00211416-00211469": "Sounds good.", "iB6sHp7ecAA-00783-00211606-00211676": "Well, thanks everyone.", "iB6sHp7ecAA-00784-00211677-00211751": "When is the next?", "iB6sHp7ecAA-00785-00211752-00212110": "The next session, as in six weeks time, so that will be.", "iB6sHp7ecAA-00786-00212248-00212396": "That's coming up in April, isn't it?", "iB6sHp7ecAA-00787-00212398-00212477": "It's early April.", "iB6sHp7ecAA-00788-00212484-00212705": "Do we know off the date off the top of our head?", "iB6sHp7ecAA-00789-00212706-00212758": "What's the date?", "iB6sHp7ecAA-00790-00212830-00212879": "I don't.", "iB6sHp7ecAA-00791-00212859-00213316": "I we'll just say six weeks you will notice it on Twitter.", "iB6sHp7ecAA-00792-00213203-00213466": "We'll put it as usual.", "iB6sHp7ecAA-00793-00213467-00213907": "Yeah, we put everything in the DC community.org/community", "iB6sHp7ecAA-00794-00213907-00214036": "underscore calls.", "iB6sHp7ecAA-00795-00214071-00214442": "I'll put the link there and then there's the next call, next", "iB6sHp7ecAA-00796-00214442-00214534": "community call.", "iB6sHp7ecAA-00797-00214535-00214920": "Unusually, we update this with the date, so we'll try to do", "iB6sHp7ecAA-00798-00214920-00215312": "that and people can find the, you know, all the informations", "iB6sHp7ecAA-00799-00215312-00215703": "again there and we will also publish the recording on the DC", "iB6sHp7ecAA-00800-00215703-00215890": "Community calls page as well.", "iB6sHp7ecAA-00801-00215946-00215992": "Yep.", "iB6sHp7ecAA-00802-00216010-00216372": "And I guess finally, last shout out, we're always instill in", "iB6sHp7ecAA-00803-00216372-00216740": "need of community reviewers, reviewers, reviewers, reviewers.", "iB6sHp7ecAA-00804-00216952-00217265": "Yeah, we're all so swamped and I think everyone is swamped.", "iB6sHp7ecAA-00805-00217266-00217588": "But if you have a little bit of time, wanna do a review, there", "iB6sHp7ecAA-00806-00217588-00217870": "are a bunch of PR's out there that we're trying to get", "iB6sHp7ecAA-00807-00217870-00217911": "through.", "iB6sHp7ecAA-00808-00217912-00218351": "So just head over to DSC Community GitHub and check out", "iB6sHp7ecAA-00809-00218351-00218713": "what PR's are open and it will be all commit.", "iB6sHp7ecAA-00810-00218714-00219044": "It will contribute an issue, but the the real challenge we have", "iB6sHp7ecAA-00811-00219044-00219112": "is PR review.", "iB6sHp7ecAA-00812-00219127-00219376": "At the moment, cool.", "iB6sHp7ecAA-00813-00219385-00219646": "We'll wrap it up and I'll stop the recording now.", "iB6sHp7ecAA-00814-00219646-00219765": "Thank you everyone.", "iB6sHp7ecAA-00815-00219894-00219965": "Great to see you all."}}, {"audio_id": "iBfZL1YRiyk", "text": {"iBfZL1YRiyk-00000-00000331-00000469": "up", "iBfZL1YRiyk-00001-00001101-00001258": "thing", "iBfZL1YRiyk-00002-00001979-00002141": "wood", "iBfZL1YRiyk-00003-00002813-00002972": "but", "iBfZL1YRiyk-00004-00003609-00003747": "where", "iBfZL1YRiyk-00005-00004440-00004607": "much", "iBfZL1YRiyk-00006-00005409-00005563": "school", "iBfZL1YRiyk-00007-00006318-00006485": "were", "iBfZL1YRiyk-00008-00007153-00007318": "call", "iBfZL1YRiyk-00009-00008032-00008172": "might", "iBfZL1YRiyk-00010-00008885-00009032": "light", "iBfZL1YRiyk-00011-00009725-00009904": "more", "iBfZL1YRiyk-00012-00010495-00010678": "as", "iBfZL1YRiyk-00013-00011221-00011380": "new", "iBfZL1YRiyk-00014-00011979-00012148": "main", "iBfZL1YRiyk-00015-00012836-00013005": "between", "iBfZL1YRiyk-00016-00013677-00013849": "run", "iBfZL1YRiyk-00017-00014397-00014554": "in", "iBfZL1YRiyk-00018-00015145-00015317": "open", "iBfZL1YRiyk-00019-00015984-00016132": "they", 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"iBfZL1YRiyk-00566-00469525-00469693": "between", "iBfZL1YRiyk-00567-00470374-00470539": "that", "iBfZL1YRiyk-00568-00471178-00471381": "why", "iBfZL1YRiyk-00569-00472046-00472211": "part", "iBfZL1YRiyk-00570-00472857-00473011": "these", "iBfZL1YRiyk-00571-00473733-00473878": "could", "iBfZL1YRiyk-00572-00474625-00474795": "you", "iBfZL1YRiyk-00573-00475504-00475678": "grow", "iBfZL1YRiyk-00574-00476373-00476537": "old", "iBfZL1YRiyk-00575-00477204-00477376": "open", "iBfZL1YRiyk-00576-00478076-00478222": "long", "iBfZL1YRiyk-00577-00478932-00479105": "come", "iBfZL1YRiyk-00578-00479793-00479962": "move", "iBfZL1YRiyk-00579-00480580-00480748": "she", "iBfZL1YRiyk-00580-00481413-00481566": "cross", "iBfZL1YRiyk-00581-00482347-00482509": "sentence", "iBfZL1YRiyk-00582-00483222-00483400": "want", "iBfZL1YRiyk-00583-00484032-00484202": "rain", "iBfZL1YRiyk-00584-00484875-00485025": "horse", "iBfZL1YRiyk-00585-00485705-00485876": "may", "iBfZL1YRiyk-00586-00486418-00486587": "I", "iBfZL1YRiyk-00587-00487136-00487315": "came", "iBfZL1YRiyk-00588-00487920-00488089": "men", "iBfZL1YRiyk-00589-00488736-00488891": "plant", "iBfZL1YRiyk-00590-00489556-00489716": "here", "iBfZL1YRiyk-00591-00490329-00490502": "base", "iBfZL1YRiyk-00592-00491191-00491349": "spell", "iBfZL1YRiyk-00593-00492028-00492198": "near", "iBfZL1YRiyk-00594-00492843-00493003": "over", "iBfZL1YRiyk-00595-00493724-00493877": "place", "iBfZL1YRiyk-00596-00494509-00494674": "he", "iBfZL1YRiyk-00597-00495197-00495364": "sea", "iBfZL1YRiyk-00598-00495949-00496101": "all", "iBfZL1YRiyk-00599-00496754-00496910": "stand"}}, {"audio_id": "iBuwiMxrjro", "text": {"iBuwiMxrjro-00000-00000115-00000925": "So, we have a stack of these, so it is important that all holes align. However, I hand-drilled", "iBuwiMxrjro-00001-00000925-00002200": "them back in the day so they were not properly aligned. Now let's realign them with the CNC machine.", "iBuwiMxrjro-00002-00002300-00002760": "Spindle: On.", "iBuwiMxrjro-00003-00003400-00003629": "BeagleG"}}, {"audio_id": "iBeftn2ApU0", "text": {"iBeftn2ApU0-00000-00000750-00001062": "today we're going to be learning about how", "iBeftn2ApU0-00001-00001062-00001400": "electrons are organized within an atom", "iBeftn2ApU0-00002-00001400-00001620": "electrons in an atom are organized into different levels", "iBeftn2ApU0-00003-00001634-00001868": "sub-levels and orbitals within the atom", "iBeftn2ApU0-00004-00001884-00002284": "so the first step is to learn about the energy levels", "iBeftn2ApU0-00005-00002300-00002708": "the energy levels basically", "iBeftn2ApU0-00006-00002728-00003702": "if we have the nucleus, the energy levels of an atom are kind of like concentric circles", "iBeftn2ApU0-00007-00003727-00004165": "going around the nucleus it would actually be three-dimensional", "iBeftn2ApU0-00008-00004165-00004561": "but the energy level that is closest to the nucleus", "iBeftn2ApU0-00009-00004561-00004973": "will be designated energy level one and", "iBeftn2ApU0-00010-00004973-00005446": "the next energy level would be energy level two", "iBeftn2ApU0-00011-00005446-00005944": "and so on and so forth and if we drew a fourth one it would be energy level 4", "iBeftn2ApU0-00012-00005944-00006262": "okay so these are the main energy levels", "iBeftn2ApU0-00013-00006262-00006606": "each level can hold a specific number of electrons", "iBeftn2ApU0-00014-00006606-00007097": "so once the first energy level is full then, we would start to put electrons on", "iBeftn2ApU0-00015-00007097-00007237": "the second energy level", "iBeftn2ApU0-00016-00007237-00007644": "and when it is full we've moved to the third energy level and begin to fill it", "iBeftn2ApU0-00017-00007719-00008419": "and we would do this consecutively", "iBeftn2ApU0-00018-00008994-00009155": "so our energy levels", "iBeftn2ApU0-00019-00009155-00009479": "we have energy level one, two", "iBeftn2ApU0-00020-00009479-00009845": "three, and four", "iBeftn2ApU0-00021-00009845-00010187": "okay so for energy level one", "iBeftn2ApU0-00022-00010187-00010585": "every energy level is subdivided into sub levels", "iBeftn2ApU0-00023-00010585-00011189": "the sub levels actually have letter designations", "iBeftn2ApU0-00024-00011288-00011932": "in energy level one, we have one sub level and it's designated letter S", "iBeftn2ApU0-00025-00011946-00012378": "okay, for energy level two, we have two sub levels", "iBeftn2ApU0-00026-00012380-00012816": "we have s and we have p", "iBeftn2ApU0-00027-00012838-00013163": "for the third energy level we have three sub levels", "iBeftn2ApU0-00028-00013165-00013785": "s, p, and d; and for the fourth energy level we have four sub levels", "iBeftn2ApU0-00029-00013785-00014116": "s, p, d, and f", "iBeftn2ApU0-00030-00014116-00014668": "okay so whatever the energy level number is that's how many sub levels there are", "iBeftn2ApU0-00031-00014668-00015079": "these sub levels are then again divided", "iBeftn2ApU0-00032-00015079-00015576": "into orbitals; orbitals are the areas where you're most likely to find the", "iBeftn2ApU0-00033-00015576-00015740": "electrons in the atom", "iBeftn2ApU0-00034-00015740-00016440": "each sublevel has a specific number orbitals", "iBeftn2ApU0-00035-00016498-00016832": "the s sub level contains one orbital", "iBeftn2ApU0-00036-00016832-00017364": "the p sub level contains three orbitals", "iBeftn2ApU0-00037-00017810-00018246": "the d sub level contains five orbitals", "iBeftn2ApU0-00038-00018282-00018804": "and the f sub level contains 7 orbitals", "iBeftn2ApU0-00039-00018804-00019214": "these orbitals are kind of like", "iBeftn2ApU0-00040-00019214-00019666": "the rooms where you're most likely to find those electrons in the atom", "iBeftn2ApU0-00041-00019708-00020234": "each orbital con hold a maximum of two electrons each", "iBeftn2ApU0-00042-00020258-00020723": "so we can determine how many electrons each sub level and level can hold", "iBeftn2ApU0-00043-00020764-00021672": "so number of electrons per sub level", "iBeftn2ApU0-00044-00021916-00022580": "if each orbital can hold a maximum of two electrons the s sub level has one orbital", "iBeftn2ApU0-00045-00022581-00022925": "it can hold two electrons", "iBeftn2ApU0-00046-00022992-00023736": "so two electrons for the s; the p has three orbitals so it can hold two electrons in each orbital", "iBeftn2ApU0-00047-00023756-00024178": "which gives you a total of six electrons", "iBeftn2ApU0-00048-00024606-00025474": "the d sub level has five orbitals so it can hold a maximum of ten electrons", "iBeftn2ApU0-00049-00025514-00026227": "and last but not least the f sub level", "iBeftn2ApU0-00050-00026258-00026742": "can hold a maximum of fourteen electrons", "iBeftn2ApU0-00051-00026768-00027433": "all of the electrons that are part of an atom are going to be organized into a level", "iBeftn2ApU0-00052-00027434-00027761": "in the sublevel we're going to fill them", "iBeftn2ApU0-00053-00027761-00028237": "by starting with our lowest energy level first and then the lowest sublevel", "iBeftn2ApU0-00054-00028237-00028541": "when it's full we move to the next energy level", "iBeftn2ApU0-00055-00028541-00028945": "fill the first sub level then we fill the second sub level", "iBeftn2ApU0-00056-00028945-00029377": "and then we move to the next energy level and will move through these", "iBeftn2ApU0-00057-00029377-00029708": "and fill each consecutive level", "iBeftn2ApU0-00058-00029708-00030295": "the order love the feeling is actually not the same as listed on this chart", "iBeftn2ApU0-00059-00030295-00030730": "we will go to the periodic table to discuss how these different levels and", "iBeftn2ApU0-00060-00030730-00031022": "sub levels are filled", "iBeftn2ApU0-00061-00031844-00032020": "here we go", "iBeftn2ApU0-00062-00032139-00032662": "so on the periodic table we can actually divide the periodic table", "iBeftn2ApU0-00063-00032662-00033062": "into our different sub level groups if you look", "iBeftn2ApU0-00064-00033062-00033553": "at the first two columns of the periodic table which we have highlighted", "iBeftn2ApU0-00065-00033553-00033999": "and it also includes helium which is over on the right side of the periodic table", "iBeftn2ApU0-00066-00034030-00034613": "these make up your s block elements, so that means the last electron", "iBeftn2ApU0-00067-00034613-00035025": "in the atom is going to be in the s sub level", "iBeftn2ApU0-00068-00035198-00035696": "the p block are these six columns over here", "iBeftn2ApU0-00069-00035697-00036156": "that means the last electrons in that atom will be", "iBeftn2ApU0-00070-00036156-00036468": "in the p sub level", "iBeftn2ApU0-00071-00036498-00037108": "the d block are the middle elements here and they represent the transition elements", "iBeftn2ApU0-00072-00037109-00037677": "their last electrons as we do our organization scheme will end up in the d sub level", "iBeftn2ApU0-00073-00037704-00038036": "and last but not least we have our", "iBeftn2ApU0-00074-00038037-00038381": "f block down here the lanthanides and actinides", "iBeftn2ApU0-00075-00038381-00038681": "are part of the f block", "iBeftn2ApU0-00076-00038681-00039044": "so if you recall", "iBeftn2ApU0-00077-00039044-00039784": "our s sub level elements can hold a maximum of two electrons", "iBeftn2ApU0-00078-00039809-00040187": "right, so these are the first two columns RP cell levels can hold", "iBeftn2ApU0-00079-00040208-00040684": "our p sub levels can hold a maximum of six electrons", "iBeftn2ApU0-00080-00040696-00041209": "so if we look if we look at our p block we have one, two, three, four, five, six columns", "iBeftn2ApU0-00081-00041209-00041683": "those would be the six electrons that would fill the p block for that energy level", "iBeftn2ApU0-00082-00041746-00042342": "the d block d-sub level can hold a maximum of ten electrons", "iBeftn2ApU0-00083-00042343-00042709": "there are ten columns across the d block here", "iBeftn2ApU0-00084-00042709-00043171": "so that means that these electrons would fill the d sub level", "iBeftn2ApU0-00085-00043190-00043630": "and last but not least we have our f block again", "iBeftn2ApU0-00086-00043662-00044068": "f has seven orbitals, can hold a maximum of fourteen electrons", "iBeftn2ApU0-00087-00044069-00044869": "and there are fourteen elements across here so those would be our fourteen electrons that would fill", "iBeftn2ApU0-00088-00044952-00045440": "from this information about how the elements are organized", "iBeftn2ApU0-00089-00045470-00045952": "we can then do orbital diagrams and electron configurations", "iBeftn2ApU0-00090-00045964-00046458": "which will then be the next way we will use this information"}}, {"audio_id": "iBGRAQoQkWk", "text": {"iBGRAQoQkWk-00000-00002182-00002724": "JWS-A1 is an oil-free magnum compressor with an innovative design.", "iBGRAQoQkWk-00001-00002862-00003016": "What is this innovation about?", "iBGRAQoQkWk-00002-00003186-00003678": "The whole body of the pump and tank has been re-invented in order to", "iBGRAQoQkWk-00003-00003734-00003934": "ensure maximum mobility of the compressor,", "iBGRAQoQkWk-00004-00003978-00004382": "to protect against accidental damage and to maximize the ease of use.", "iBGRAQoQkWk-00005-00004676-00005052": "Please see the folding handle - with a soft non-slip grip -", "iBGRAQoQkWk-00006-00005234-00005730": "which you can drive the compressor in any place in a very easy and convenient way", "iBGRAQoQkWk-00007-00006306-00006506": "This handle is folded", "iBGRAQoQkWk-00008-00007020-00007348": "In addition, on both sides there are additional grips to carry", "iBGRAQoQkWk-00009-00007968-00008392": "The compressor can work in two positions vertically and horizontally", "iBGRAQoQkWk-00010-00008720-00008920": "in a vertical position it takes up very little space", "iBGRAQoQkWk-00011-00009162-00009670": "In turn, in a horizontal position, we have a shelf that can be used for eg the position of tools.", "iBGRAQoQkWk-00012-00009992-00010802": "The JWS-A1 compressor panel is equipped with two manometers showing one pressure in the cylinder, the second pressure at the outlet.", "iBGRAQoQkWk-00013-00011182-00011444": "The black knob is used to regulate this pressure", "iBGRAQoQkWk-00014-00011636-00012020": "Next to the two outlet sockets - typical quick couplings.", "iBGRAQoQkWk-00015-00012202-00012564": "These two splines on the side are handles for winding, for example, loose cable.", "iBGRAQoQkWk-00016-00012774-00013374": "Now, technical data - and here is another interesting thing - the compressor beats up to 9 bar.", "iBGRAQoQkWk-00017-00013680-00013880": "The capacity of the tank is 20 liters.", "iBGRAQoQkWk-00018-00014022-00014300": "The pump is an oil-free, two-cylinder design - very durable.", "iBGRAQoQkWk-00019-00014602-00015246": "The motor on the pump is wound with copper, which is rare nowadays - which increases the durability of the compressor.", "iBGRAQoQkWk-00020-00015500-00015969": "In addition, the compressor has protection against overheating and power failure.", "iBGRAQoQkWk-00021-00016269-00016696": "The compressor is quiet - its volume fluctuates around 55 decibels."}}, {"audio_id": "iBINxisFj8U", "text": {"iBINxisFj8U-00000-00000460-00000560": "Learn more about humanoid robotics at https://www.actiontoaction.ai", "iBINxisFj8U-00001-00002140-00002256": "https://www.actiontoaction.ai"}}, {"audio_id": "iBTN9TeRZBg", "text": {"iBTN9TeRZBg-00000-00001685-00002172": "Hey there, and welcome to the third chapter of the plant microbiome module.", "iBTN9TeRZBg-00001-00002172-00002620": "Within this module you already got insights into the plant microbiome, which was further", "iBTN9TeRZBg-00002-00002620-00002902": "exemplified on the apple plant.", "iBTN9TeRZBg-00003-00002902-00003440": "Today I will explain you how we can use the microbiome as sustainable and ecosystem-friendly", "iBTN9TeRZBg-00004-00003440-00003872": "alternative to current crop production systems.", "iBTN9TeRZBg-00005-00003872-00004057": "And we do need sustainable alternatives.", "iBTN9TeRZBg-00006-00004057-00004647": "It is predicted that world´s population will reach 11 billion by 2050.", "iBTN9TeRZBg-00007-00004647-00005380": "In correlation to that, projection models showed a 56% increase of total global food", "iBTN9TeRZBg-00008-00005380-00005480": "demand.", "iBTN9TeRZBg-00009-00005480-00006182": "At the same time, by 2050, the available arable land per person will be reduced to 50%.", "iBTN9TeRZBg-00010-00006182-00006831": "Today, one third of world´s soil is already degraded, and soil degradation is an irreversible", "iBTN9TeRZBg-00011-00006831-00006995": "process.", "iBTN9TeRZBg-00012-00006995-00007504": "Apart from urbanization, it is especially the agricultural misuse during the past 100", "iBTN9TeRZBg-00013-00007504-00008159": "years that led to soil degradation, pollution, climate change, a significant loss of biodiversity,", "iBTN9TeRZBg-00014-00008159-00008754": "the emergence of multi-resistant pathogens, and an overall disbalance of ecological cycles", "iBTN9TeRZBg-00015-00008754-00009001": "on the entire planet.", "iBTN9TeRZBg-00016-00009001-00009540": "To meet the nutritional demands and guarantee also safe food for a growing world population", "iBTN9TeRZBg-00017-00009540-00009972": "it is imperative to produce food sustainably.", "iBTN9TeRZBg-00018-00009972-00010531": "The microbiome is one of the most promising solutions to increase agricultural productivity", "iBTN9TeRZBg-00019-00010531-00010946": "while protecting environmental health.", "iBTN9TeRZBg-00020-00010946-00011484": "The first plant-beneficial effects of microbes were discovered already in the 1890s, for", "iBTN9TeRZBg-00021-00011484-00011840": "nitrogen-fixing bacteria on the roots of legume plants.", "iBTN9TeRZBg-00022-00011840-00012406": "After that, more and more microbes were identified to provide essential nutrients to the plant", "iBTN9TeRZBg-00023-00012406-00012903": "or to enhance the plant´s capability to take up those nutrients.", "iBTN9TeRZBg-00024-00012903-00013358": "Microbes support the plant during germination and stimulate growth by stress alleviation", "iBTN9TeRZBg-00025-00013358-00013961": "and the production of growth-promoting hormones, detoxification and osmoprotective enzymes.", "iBTN9TeRZBg-00026-00013961-00014603": "In addition, microbes protect their host against pathogens by producing antimicrobial compounds", "iBTN9TeRZBg-00027-00014603-00015032": "or by triggering the induction of plant´s systemic resistance.", "iBTN9TeRZBg-00028-00015032-00015654": "However, accompanied with the loss of plant, insect, and animal diversity over the past", "iBTN9TeRZBg-00029-00015654-00016221": "century, we likely lost a large share of microbial diversity as well.", "iBTN9TeRZBg-00030-00016221-00016726": "Especially chemical pest control affects the microbial pool in the environment, since products", "iBTN9TeRZBg-00031-00016726-00017290": "that are mend to deplete one specific pathogen, often affect the whole microbial community,", "iBTN9TeRZBg-00032-00017290-00017632": "including also those, which are beneficial for the plant.", "iBTN9TeRZBg-00033-00017632-00018229": "As a result, plants might be less resilient to biotic and abiotic stress which requires", "iBTN9TeRZBg-00034-00018229-00018604": "even heavier treatments and pest control.", "iBTN9TeRZBg-00035-00018604-00019191": "But also breeding changed not only plant characteristics towards desired properties such as increased", "iBTN9TeRZBg-00036-00019191-00019769": "productivity and yield, but unintentionally it also changed the plant microbiome.", "iBTN9TeRZBg-00037-00019769-00020345": "And again, as a consequence, several of our crop plants show a reduced ability to cope", "iBTN9TeRZBg-00038-00020345-00020612": "with biotic and abiotic stress.", "iBTN9TeRZBg-00039-00020612-00021325": "However, knowing that, provides us also opportunities to develop breeding strategies under the consideration", "iBTN9TeRZBg-00040-00021325-00021466": "of the microbiome.", "iBTN9TeRZBg-00041-00021466-00022031": "This means, with breeding we can select for specific plant traits that enrich beneficial", "iBTN9TeRZBg-00042-00022031-00022131": "microorganisms.", "iBTN9TeRZBg-00043-00022131-00022737": "Here, the microbiomes of wild relatives of our crop plants can be helpful, since understanding", "iBTN9TeRZBg-00044-00022737-00023288": "the interactions and processes which occur under natural and balanced conditions are", "iBTN9TeRZBg-00045-00023288-00023549": "also highly informative for agriculture.", "iBTN9TeRZBg-00046-00023549-00024148": "This idea has been initially postulated within the so-called back-to-the-roots concept for", "iBTN9TeRZBg-00047-00024148-00024622": "agriculture, which´s main objective is to restore biodiversity.", "iBTN9TeRZBg-00048-00024622-00025263": "In this regard, also seed microbiomes, including the ones of wild plants, are very interesting.", "iBTN9TeRZBg-00049-00025263-00025757": "Remember, microbes that are transmitted to the next generation through seeds, emerged", "iBTN9TeRZBg-00050-00025757-00026272": "from an intimate relation with the host plant and might feature some desired functions for", "iBTN9TeRZBg-00051-00026272-00026527": "the emerging seedling.", "iBTN9TeRZBg-00052-00026527-00027072": "Another promising resource for plant-beneficial microbiota are disease-suppressive soils.", "iBTN9TeRZBg-00053-00027072-00027645": "In such soils, the abundance of pathogenic soil-borne microorganisms is strongly reduced", "iBTN9TeRZBg-00054-00027645-00028208": "due to the antagonistic activity of a diverse microbiome and the plants that are present.", "iBTN9TeRZBg-00055-00028208-00028808": "So, what are microbial products, how are they produced, and how can they be applied?", "iBTN9TeRZBg-00056-00028808-00029370": "The search for plant-beneficial microorganisms usually starts by selecting habitats with", "iBTN9TeRZBg-00057-00029370-00029597": "interesting characteristics.", "iBTN9TeRZBg-00058-00029597-00030144": "Such as the before mentioned natural environments, wild relatives of crop plants or disease-suppressive", "iBTN9TeRZBg-00059-00030144-00030244": "soils.", "iBTN9TeRZBg-00060-00030244-00030869": "In the lab, microbes are isolated from such seeds, plants, or soils by cultivating them", "iBTN9TeRZBg-00061-00030869-00031108": "on nutrient-rich media.", "iBTN9TeRZBg-00062-00031108-00031639": "Those isolates are then screened for desired plant-beneficial functions by molecular, analytic", "iBTN9TeRZBg-00063-00031639-00031839": "and bioinformatic tools.", "iBTN9TeRZBg-00064-00031839-00032454": "Afterwards, they are re-introduced into the living system; first under sterile, then under", "iBTN9TeRZBg-00065-00032454-00032827": "non-sterile conditions in soils in the greenhouse.", "iBTN9TeRZBg-00066-00032827-00033425": "If everything works well and the plant-beneficial effects are consistent and statistically significant,", "iBTN9TeRZBg-00067-00033425-00033968": "such microbes are formulated into a product which is applied first on small scale, and", "iBTN9TeRZBg-00068-00033968-00034362": "then on large-scale agricultural fields.", "iBTN9TeRZBg-00069-00034362-00034834": "Microbial products can be either directly applied in soil near the roots of the seedling", "iBTN9TeRZBg-00070-00034834-00035222": "or integrated in seed coatings.", "iBTN9TeRZBg-00071-00035222-00035776": "Microbial products can be single microorganisms or synthetic microbial communities of different", "iBTN9TeRZBg-00072-00035776-00036075": "complexity, so-called SynComs.", "iBTN9TeRZBg-00073-00036075-00036559": "SynComs follow a community-based approach, which is being more and more accepted in science", "iBTN9TeRZBg-00074-00036559-00037131": "and agriculture to provide long-term, persistent and multi-functional growth promotion to crop", "iBTN9TeRZBg-00075-00037131-00037231": "plants.", "iBTN9TeRZBg-00076-00037231-00037808": "Another option is the application of microbial volatile organic compounds.", "iBTN9TeRZBg-00077-00037808-00038334": "Such metabolites are produced by microbes to communicate with the plant or to suppress", "iBTN9TeRZBg-00078-00038334-00038475": "plant pathogens.", "iBTN9TeRZBg-00079-00038475-00039062": "Volatile organic compounds can also be captured from the producing microbes in the lab and", "iBTN9TeRZBg-00080-00039062-00039338": "are afterwards applied on fields.", "iBTN9TeRZBg-00081-00039338-00039975": "Lastly, we can also indirectly shape the microbiome towards a plant-beneficial composition by", "iBTN9TeRZBg-00082-00039975-00040271": "changing environmental conditions.", "iBTN9TeRZBg-00083-00040271-00040783": "Another critical aspect in food production is the postharvest period.", "iBTN9TeRZBg-00084-00040783-00041452": "In total, 45% of all produced vegetables and fruits is lost on the way from the field to", "iBTN9TeRZBg-00085-00041452-00042041": "the consumer; especially fungi causing food decay and spoilage represent a huge problem", "iBTN9TeRZBg-00086-00042041-00042141": "worldwide.", "iBTN9TeRZBg-00087-00042141-00042686": "Currently, heavy countermeasures, mainly based on chemical fungicides, are taken to maintain", "iBTN9TeRZBg-00088-00042686-00042974": "the quality during the storage period.", "iBTN9TeRZBg-00089-00042974-00043816": "But also here, after harvest, microbial products can be applied to supplement chemical treatments.", "iBTN9TeRZBg-00090-00043816-00044186": "Microbiome management for crop production has already been proven highly successful", "iBTN9TeRZBg-00091-00044186-00044310": "in many cases.", "iBTN9TeRZBg-00092-00044310-00044682": "However, on large scale, it is still big challenge.", "iBTN9TeRZBg-00093-00044682-00045110": "Which is not really surprising when you consider all the environmental factors that influence", "iBTN9TeRZBg-00094-00045110-00045498": "the microbiome and it´s interactions with plants.", "iBTN9TeRZBg-00095-00045498-00046034": "And for making use of the microbiome´s benefits, we must understand and integrate all of these", "iBTN9TeRZBg-00096-00046034-00046134": "factors.", "iBTN9TeRZBg-00097-00046134-00046679": "In fact, we still need to largely expand our knowledge on the structure and function of", "iBTN9TeRZBg-00098-00046679-00047295": "the plant microbiome, in nature, in the field, after harvest, and on global scale.", "iBTN9TeRZBg-00099-00047295-00047790": "Naturally, not all crop plants growing all over the world will respond to a microbial", "iBTN9TeRZBg-00100-00047790-00047994": "treatment in the same manner.", "iBTN9TeRZBg-00101-00047994-00048586": "And also in the future, there will be no one-fits-all solution, we will rather need to elaborate", "iBTN9TeRZBg-00102-00048586-00049061": "tailored treatments to enhance the health and productivity of certain crop plants in", "iBTN9TeRZBg-00103-00049061-00049290": "a specific environment.", "iBTN9TeRZBg-00104-00049290-00049622": "And we also need to further elaborate on the methodology.", "iBTN9TeRZBg-00105-00049622-00050153": "So far, we can cultivate approximately 10% of all the microbes in our labs.", "iBTN9TeRZBg-00106-00050153-00050622": "We have to find new isolation and cultivation approaches, but also innovative methods to", "iBTN9TeRZBg-00107-00050622-00051122": "formulate them into products that we can apply on agricultural fields.", "iBTN9TeRZBg-00108-00051122-00051622": "The continuous achievements in multi-omics and culturomics, fingerprinting approaches", "iBTN9TeRZBg-00109-00051622-00052178": "and microbial network analyses are seminal tools to achieve our goal also on a global", "iBTN9TeRZBg-00110-00052178-00052278": "scale.", "iBTN9TeRZBg-00111-00052278-00052508": "So that´s it about the plant microbiome.", "iBTN9TeRZBg-00112-00052508-00053006": "I hope you agree that it is fascinating to research and promising for our future.", "iBTN9TeRZBg-00113-00053006-00053894": "Next week, we will dive into the human microbiome and its importance for your own heath.", "iBTN9TeRZBg-00114-00053894-00055066": "See you there!"}}, {"audio_id": "iCwsmaU9rcQ", "text": {"iCwsmaU9rcQ-00000-00001957-00002210": "So this morning we left out of Plymouth Harbor", "iCwsmaU9rcQ-00001-00002210-00002368": "which is about 20 miles south of", "iCwsmaU9rcQ-00002-00002368-00002522": "the busy port of Boston", "iCwsmaU9rcQ-00003-00002522-00002872": "and we left and came out about 17 nautical miles", "iCwsmaU9rcQ-00004-00002872-00003014": "until we got out here.", "iCwsmaU9rcQ-00005-00003014-00003204": "So we're running around 10 knots", "iCwsmaU9rcQ-00006-00003204-00003550": "due to right whale season so it took us a little over an hour and a half,", "iCwsmaU9rcQ-00007-00003550-00003734": "almost two hours to get out.", "iCwsmaU9rcQ-00008-00003734-00004076": "Really where we came today was the southwest corner of the sanctuary.", "iCwsmaU9rcQ-00009-00004681-00005052": "So today we have a bunch of different projects going on", "iCwsmaU9rcQ-00010-00005052-00005292": "but in part the thing that's all brought us together is", "iCwsmaU9rcQ-00011-00005292-00005526": "just trying to understand forage fish,", "iCwsmaU9rcQ-00012-00005526-00006016": "in particularly the sandlance, or sand eels, as the fishermen like to call them.", "iCwsmaU9rcQ-00013-00006380-00006709": "Sandlance, they're about this long", "iCwsmaU9rcQ-00014-00006709-00006923": "and would be a little bit thicker or thinner than my pinky.", "iCwsmaU9rcQ-00015-00006923-00007426": "They're the main forage species for whales, seabirds, and other fish.", "iCwsmaU9rcQ-00016-00008018-00008414": "They're not technically endangered, on the endangered species list,", "iCwsmaU9rcQ-00017-00008414-00009050": "but they are threatened by man-made, human-induced pressures.", "iCwsmaU9rcQ-00018-00009978-00010330": "As some people know, the Gulf of Maine, which is where Stellwagen Bank is,", "iCwsmaU9rcQ-00019-00010331-00010638": "has experienced some of the largest changes in climate,", "iCwsmaU9rcQ-00020-00010638-00010912": "especially when it comes to ocean temperatures.", "iCwsmaU9rcQ-00021-00010912-00011308": "We're having warming almost more than anywhere else in the world right now.", "iCwsmaU9rcQ-00022-00011308-00011822": "And what that could mean for very finicky sandlance is to where", "iCwsmaU9rcQ-00023-00011822-00012200": "they want to be due to ocean temperatures could really change.", "iCwsmaU9rcQ-00024-00012860-00013205": "If you wiped out the sandlance on Stellwagen, it's not like you could just", "iCwsmaU9rcQ-00025-00013205-00013434": "go off Stellwagen and find sandlance.", "iCwsmaU9rcQ-00026-00013434-00013836": "They're really highly concentrated on Stellwagen", "iCwsmaU9rcQ-00027-00013836-00014146": "and only one or two other places in the Gulf of Maine.", "iCwsmaU9rcQ-00028-00014146-00014608": "So they're very important for everything that comes here.", "iCwsmaU9rcQ-00029-00015038-00015369": "We could see a collapse of different types of fish,", "iCwsmaU9rcQ-00030-00015369-00015658": "we could certainly see a lot less whales move offshore", "iCwsmaU9rcQ-00031-00015658-00015938": "and as well as the seabirds in here.", "iCwsmaU9rcQ-00032-00016041-00016384": "We really don't know what would actually happen,", "iCwsmaU9rcQ-00033-00016384-00016662": "that's certainly something that we're working on very hard to figure out", "iCwsmaU9rcQ-00034-00016662-00016932": "but it would certainly be, we believe, disastrous.", "iCwsmaU9rcQ-00035-00018179-00018430": "Sandlance are a really tricky fish.", "iCwsmaU9rcQ-00036-00018430-00018710": "we're starting this project because they're really hard to catch", "iCwsmaU9rcQ-00037-00018710-00018942": "and study and there's not a lot known about them,", "iCwsmaU9rcQ-00038-00018942-00019382": "even though they might arguably be the most important species that we have in the sanctuary.", "iCwsmaU9rcQ-00039-00019382-00019806": "We have people involved in the project from the University of Connecticut,", "iCwsmaU9rcQ-00040-00019806-00020268": "USGS down in Woods Hole,  we also have", "iCwsmaU9rcQ-00041-00020268-00020812": "some folks involved from Boston University, and the list goes on and on.", "iCwsmaU9rcQ-00042-00020952-00021416": "When you bring in scientists that have all sorts of different interests, from", "iCwsmaU9rcQ-00043-00021417-00021998": "the geologists with their focus on the sediments and sand grain, to the plankton to", "iCwsmaU9rcQ-00044-00021998-00022404": "the sort of the adult fish ecologist,", "iCwsmaU9rcQ-00045-00022404-00023042": "we start to get a much clearer picture of what's going on.", "iCwsmaU9rcQ-00046-00024372-00024682": "It's really hard when you're out here on the water sometimes to think about what's below us,", "iCwsmaU9rcQ-00047-00024683-00025034": "so this is our only way to be able to peel back the water and look and", "iCwsmaU9rcQ-00048-00025034-00025444": "see what the surface sort of looks like the bottom.", "iCwsmaU9rcQ-00049-00025858-00026218": "And it's not just helping sandlance, it's helping the entire ecosystem.", "iCwsmaU9rcQ-00050-00026218-00026520": "If you care about whales, you should care about sandlance.", "iCwsmaU9rcQ-00051-00026520-00026856": "If you care about bluefin tuna, you should care about sandlance.", "iCwsmaU9rcQ-00052-00026856-00027430": "If you care about birds, beautiful puffins for example, you should care about sandlance.", "iCwsmaU9rcQ-00053-00027430-00027880": "Everything has to eat and if something happens to their prey, their food,", "iCwsmaU9rcQ-00054-00027880-00028238": "then you're really affecting that species.", "iCwsmaU9rcQ-00055-00028238-00028612": "If sandlance were kind of on their own,", "iCwsmaU9rcQ-00056-00028616-00028832": "doing their own little thing without anything eating them,", "iCwsmaU9rcQ-00057-00028832-00029044": "you probably wouldn't care about them.", "iCwsmaU9rcQ-00058-00029045-00029468": "But they're so important in the ecosystem that we have to care."}}, {"audio_id": "iD62nFKTwE8", "text": {"iD62nFKTwE8-00000-00000000-00008400": "🌟 🇺🇸 Walt Aoi Beyblade Beyblade — Shop GrandStart.ru 🌟"}}, {"audio_id": "iDnRZ_WMdnU", "text": {"iDnRZ_WMdnU-00000-00000725-00001065": "Wyoming hosts many wonderful historic places.", "iDnRZ_WMdnU-00001-00001065-00001610": "The lodge and property at Ranch A, located near Beulah Wyoming is no exception.", "iDnRZ_WMdnU-00002-00001610-00002224": "Ranch A is a historic vacation property on the banks of Sand Creek in far eastern Wyoming.", "iDnRZ_WMdnU-00003-00002224-00002888": "The property was originally settled by Theodore Roosevelt’s cousin in 1877 and was visited", "iDnRZ_WMdnU-00004-00002888-00003058": "by the president.", "iDnRZ_WMdnU-00005-00003058-00003550": "The property was eventually sold to a businessman from New York, named Mosses Annenberg.", "iDnRZ_WMdnU-00006-00003550-00004240": "When Mr. Annenberg purchased the 640 acre property in 1931 he hired four brothers to", "iDnRZ_WMdnU-00007-00004240-00004523": "construct a lodge and a barn.", "iDnRZ_WMdnU-00008-00004523-00005080": "The lodge was constructed from pine logs on the property at a cost of 1,000,000 dollars.", "iDnRZ_WMdnU-00009-00005080-00005360": "Exquisite decor was used in each room.", "iDnRZ_WMdnU-00010-00005360-00005962": "Thomas Molesworth, a famous furniture maker from Cody, was commissioned to make 245 pieces", "iDnRZ_WMdnU-00011-00005962-00006092": "for the lodge.", "iDnRZ_WMdnU-00012-00006092-00006326": "His biggest commission ever.", "iDnRZ_WMdnU-00013-00006326-00006852": "Mr. Annenberg eventually ran into tax evasion problems and was forced to sell the property.", "iDnRZ_WMdnU-00014-00006852-00007712": "The Ranch changed hands many times after this and is now owed by the State of Wyoming.", "iDnRZ_WMdnU-00015-00007712-00008260": "The well-built lodge and barn have been completely restored and are now used as a learning center.", "iDnRZ_WMdnU-00016-00008260-00008671": "From the University of Wyoming Extension, I’m Brian Sebade, Exploring the Nature of", "iDnRZ_WMdnU-00017-00008671-00008700": "Wyoming"}}, {"audio_id": "iDwsWcReg0I", "text": {"iDwsWcReg0I-00000-00000152-00000485": "So the majority of you saying its an attractive", "iDwsWcReg0I-00001-00000485-00000846": "potential energy.", "iDwsWcReg0I-00002-00000846-00001230": "The potential energy goes down when these two", "iDwsWcReg0I-00003-00001230-00001743": "things get closer together, so forces  are acting to bring them closer together", "iDwsWcReg0I-00004-00001743-00002066": "and that means this one is being pulled that way in this is being pulled that", "iDwsWcReg0I-00005-00002066-00002255": "way which means they are attracting", "iDwsWcReg0I-00006-00002255-00002584": "each other. They're attracting each other", "iDwsWcReg0I-00007-00002584-00002943": "means the potential energy goes down when they get closer together.", "iDwsWcReg0I-00008-00002943-00003336": "Now this one you actually know, this is", "iDwsWcReg0I-00009-00003336-00003697": "at least somewhat physical. Here's the ball,", "iDwsWcReg0I-00010-00003697-00004011": "the earth is the other object, they", "iDwsWcReg0I-00011-00004011-00004444": "attract each other, which means the potential goes down", "iDwsWcReg0I-00012-00004444-00004895": "as they get closer together and that's what you see there.", "iDwsWcReg0I-00013-00004895-00005341": "Potential energy going down as the two things get closer together.", "iDwsWcReg0I-00014-00005341-00005780": "The force", "iDwsWcReg0I-00015-00005780-00006212": "on... the force on this one", "iDwsWcReg0I-00016-00006212-00006653": "is directly toward that, it's being pulled toward the other one.", "iDwsWcReg0I-00017-00006653-00006976": "The force on this one is directly toward that  one.", "iDwsWcReg0I-00018-00006976-00007293": "It's another thing about", "iDwsWcReg0I-00019-00007293-00007686": "interactions that that you'll talk about a lot more in 7B", "iDwsWcReg0I-00020-00007686-00008014": "is that both objects feel", "iDwsWcReg0I-00021-00008014-00008513": "an interaction equally in oppositely, so this one", "iDwsWcReg0I-00022-00008513-00008890": "feels a force down and to the left", "iDwsWcReg0I-00023-00008890-00009360": "and this one feels the same magnitude force", "iDwsWcReg0I-00024-00009360-00009672": "but not down and to the left instead up and to the right.", "iDwsWcReg0I-00025-00009672-00009986": "Exactly equal and opposite forces.", "iDwsWcReg0I-00026-00009986-00010686": "Any questions about that one?", "iDwsWcReg0I-00027-00011110-00011451": "So I'm gonna skip ahead to this one.", "iDwsWcReg0I-00028-00011451-00011805": "Suppose the distance between these two objects is shown by", "iDwsWcReg0I-00029-00011805-00012200": "r, as shown to the right. Potential energy,", "iDwsWcReg0I-00030-00012200-00012501": "in other words, the interaction energy of this pair of objects,", "iDwsWcReg0I-00031-00012501-00012811": "okay, so now we're going to give it a complicated shape.", "iDwsWcReg0I-00032-00012811-00013379": "Here's the potential energy, here's the distance between the two objects here's", "iDwsWcReg0I-00033-00013379-00013725": "r. Here's r equals zero. Here's r equals", "iDwsWcReg0I-00034-00013725-00014135": "four Angstroms [where] the potential energy is zero.", "iDwsWcReg0I-00035-00014135-00014553": "It goes down and then it comes back up again.", "iDwsWcReg0I-00036-00014553-00014921": "Is the interaction between these two objects", "iDwsWcReg0I-00037-00014921-00015336": "attractive or repulsive? Are the two objects", "iDwsWcReg0I-00038-00015336-00015676": "attracting each other or repealing each other?", "iDwsWcReg0I-00039-00015676-00016087": "And I'll remind you", "iDwsWcReg0I-00040-00016087-00016524": "the force always acts to decrease", "iDwsWcReg0I-00041-00016524-00016656": "the potential energy."}}, {"audio_id": "iDxwrYmV6go", "text": {"iDxwrYmV6go-00000-00000020-00000280": "I'm going to Child Vision now", "iDxwrYmV6go-00001-00000730-00001080": "SIÚN : It's a place that has lots of animals.", "iDxwrYmV6go-00002-00001830-00001939": "JANE : How are you?", "iDxwrYmV6go-00003-00002540-00002730": "SIÚN : There's a  goat there....", "iDxwrYmV6go-00004-00002730-00002900": "That's a goat!", "iDxwrYmV6go-00005-00003000-00003350": "And you're not allowed to give her leaves.", "iDxwrYmV6go-00006-00003360-00003550": "SIÚN : And sheep...", "iDxwrYmV6go-00007-00004450-00004600": "Houses! Look.", "iDxwrYmV6go-00008-00004850-00005080": "Look, there's a wishing well there.", "iDxwrYmV6go-00009-00005100-00005680": "And I suppose, the children were putting their hands in to get the money...", "iDxwrYmV6go-00010-00005680-00006280": "...so they put this piece of metal here so the children won't get the money.", "iDxwrYmV6go-00011-00006340-00006500": "They were stealing the money?      Yes.", "iDxwrYmV6go-00012-00006540-00006940": "Do you see that one with the black tail?    Yes.", "iDxwrYmV6go-00013-00007100-00007400": "That's a cockerel.   JANE:  A cockerel!", "iDxwrYmV6go-00014-00007590-00007990": "And look at those strange birds....", "iDxwrYmV6go-00015-00007990-00008530": "When they put their wings up and down, I think they look really strange", "iDxwrYmV6go-00016-00008780-00009300": "And that's a.... FEARGAL : Peacock. SIÚN : Yeah, peacock. JANE : Peacock.", "iDxwrYmV6go-00017-00010650-00011500": "Nice nice. No!  No, nice nice....Yeah, nice. Nice nice. No!", "iDxwrYmV6go-00018-00011530-00012010": "SIÚN: The rabbits have a fairy door. JANE: The rabbits do?", "iDxwrYmV6go-00019-00012040-00012480": "SIÚN : The rabbits are friendly because they come up to you.", "iDxwrYmV6go-00020-00012940-00013130": "JANE: You're right.  FEARGAL : They're so big aren't they?", "iDxwrYmV6go-00021-00013530-00013830": "FEARGAL : That horse's name is Socks.", "iDxwrYmV6go-00022-00014280-00014530": "I'm a monkey!"}}, {"audio_id": "iDLshVSYwpM", "text": {"iDLshVSYwpM-00000-00000762-00001242": "Beat the heavy cream into whipping cream", "iDLshVSYwpM-00001-00003492-00005042": "Add the sweetened condensed milk and the praline and mix", "iDLshVSYwpM-00002-00010100-00010612": "Cut the tsoureki in chunks (a much as you like)", "iDLshVSYwpM-00003-00011316-00012972": "Add some cognac and put in the cream mix", "iDLshVSYwpM-00004-00013154-00013618": "Blend and place in a container with lid", "iDLshVSYwpM-00005-00016832-00017358": "Optionally spread some praline and use a toothpick to make shapes", "iDLshVSYwpM-00006-00017392-00017838": "Chill at least 12 hours before serving"}}, {"audio_id": "iDPpwzK8074", "text": {"iDPpwzK8074-00000-00000000-00000200": "Hello Friends How are You.", "iDPpwzK8074-00001-00000271-00000321": "Please Like share a d subscribe my channel friends"}}, {"audio_id": "iDQgTBhNCWI", "text": {"iDQgTBhNCWI-00000-00000000-00000296": "I love Oakland. You know why?", "iDQgTBhNCWI-00001-00000296-00000583": "Because it's real.", "iDQgTBhNCWI-00002-00000583-00000737": "When Trump was declared president,", "iDQgTBhNCWI-00003-00000737-00000914": "We didn't just yell at the TV,", "iDQgTBhNCWI-00004-00000914-00001111": "or make smart remarks on the internet,", "iDQgTBhNCWI-00005-00001111-00001314": "we went outside.", "iDQgTBhNCWI-00006-00001314-00001778": "We went outside, face-to-face, and made noise.", "iDQgTBhNCWI-00007-00001778-00002122": "You can sit at home and condemn us on social media", "iDQgTBhNCWI-00008-00002122-00002399": "but ask yourself - what were you prepared to do", "iDQgTBhNCWI-00009-00002399-00002582": "when Trump lost?", "iDQgTBhNCWI-00010-00002582-00002736": "What would you have done,", "iDQgTBhNCWI-00011-00002736-00003026": "if Trump won the popular vote by 6,000,000", "iDQgTBhNCWI-00012-00003026-00003360": "and the presidency was handed to Hillary anyway?", "iDQgTBhNCWI-00013-00003360-00003646": "Would you have cried \"the system is rigged,\"", "iDQgTBhNCWI-00014-00003646-00003797": "like your candidate did?", "iDQgTBhNCWI-00015-00003797-00004177": "Would you have gone outside? Would you have gathered?", "iDQgTBhNCWI-00016-00004177-00004351": "Absolutely.", "iDQgTBhNCWI-00017-00004351-00004637": "So here's what's happening in Oakland.", "iDQgTBhNCWI-00018-00004637-00004878": "We're not just yelling and breaking stuff.", "iDQgTBhNCWI-00019-00004878-00005058": "That's just the part that makes the news,", "iDQgTBhNCWI-00020-00005058-00005388": "because the media likes to show you scary things.", "iDQgTBhNCWI-00021-00005388-00005642": "Protests do bring out angry people,", "iDQgTBhNCWI-00022-00005642-00005912": "and some of those people behave badly.", "iDQgTBhNCWI-00023-00005912-00006136": "The rest of us apologize for that.", "iDQgTBhNCWI-00024-00006136-00006343": "But we need to do this.", "iDQgTBhNCWI-00025-00006343-00006696": "Don't believe your social media brings you the whole story.", "iDQgTBhNCWI-00026-00006696-00006980": "We came out for ourselves.", "iDQgTBhNCWI-00027-00006980-00007360": "We held hands. We got together and played music.", "iDQgTBhNCWI-00028-00007360-00007724": "We shared messages of comfort, and for unity.", "iDQgTBhNCWI-00029-00007724-00008118": "Forming this crowd is an antidote.", "iDQgTBhNCWI-00030-00008118-00008301": "By going out and getting face-to-face,", "iDQgTBhNCWI-00031-00008304-00008705": "this community is breaking the spell of divisiveness", "iDQgTBhNCWI-00032-00008705-00008885": "cast by the media.", "iDQgTBhNCWI-00033-00008885-00009265": "This is how a community stays awake and united.", "iDQgTBhNCWI-00034-00009265-00009469": "By getting face-to-face,", "iDQgTBhNCWI-00035-00009469-00009929": "where the things you say and do have consequences.", "iDQgTBhNCWI-00036-00009936-00010316": "And the consequences of this election are real for us.", "iDQgTBhNCWI-00037-00010320-00010503": "Our issues aren't with you.", "iDQgTBhNCWI-00038-00010503-00010770": "Our issues are with that man about to take office,", "iDQgTBhNCWI-00039-00010770-00010997": "and the actions he's been promising.", "iDQgTBhNCWI-00040-00011000-00011241": "\"Oh he won't really build a border wall,", "iDQgTBhNCWI-00041-00011241-00011444": "and deport a million people, and ban Muslims,", "iDQgTBhNCWI-00042-00011444-00011631": "that was just talk,\" you say.", "iDQgTBhNCWI-00043-00011631-00012122": "Well you're right - he won't. Because we're still here.", "iDQgTBhNCWI-00044-00012122-00012522": "We're out getting reconnected and getting our confidence back.", "iDQgTBhNCWI-00045-00012525-00012872": "We won't let this president's rhetoric,", "iDQgTBhNCWI-00046-00012872-00012969": "or the mainstream media,", "iDQgTBhNCWI-00047-00012969-00013173": "keep us divided.", "iDQgTBhNCWI-00048-00013173-00013426": "And sometimes you need to come out into the street", "iDQgTBhNCWI-00049-00013426-00013630": "to keep that from happening.", "iDQgTBhNCWI-00050-00013630-00013840": "So take a break from social media,", "iDQgTBhNCWI-00051-00013843-00014260": "and come on out to Oakland, and keep things real with us.", "iDQgTBhNCWI-00052-00014260-00014544": "And you'll love this place too.", "iDQgTBhNCWI-00053-00014551-00014721": "Thank you for listening."}}, {"audio_id": "iElnXDAJjfo", "text": {"iElnXDAJjfo-00000-00000292-00000453": "1", "iElnXDAJjfo-00001-00000985-00001153": "7", "iElnXDAJjfo-00002-00001723-00001887": "3", 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"iECdDFWm-5E-00006-00003536-00003947": "hour and 15 minutes and it's only 5 bucks so it is definitely worth your", "iECdDFWm-5E-00007-00003947-00004620": "time so in this book he talks about is it morally or ethically ever right to", "iECdDFWm-5E-00008-00004620-00005067": "lie all right so it's a great great great great book that you need to check", "iECdDFWm-5E-00009-00005067-00005568": "out all right so as you can see I'm kind of excited and jazzed up about this this", "iECdDFWm-5E-00010-00005568-00006189": "is a topic that I am so so passionate about and the reason being for over 20", "iECdDFWm-5E-00011-00006189-00006773": "years of my life lying was probably the biggest part of my personality so if", "iECdDFWm-5E-00012-00006773-00007158": "you're the child of an alcoholic or addict parent one of the key symptoms of", "iECdDFWm-5E-00013-00007158-00007611": "children of alcoholic or addict parents is that we lie when it would often be", "iECdDFWm-5E-00014-00007611-00008015": "easier to just tell the truth it's part of our DNA I'll make more videos about", "iECdDFWm-5E-00015-00008015-00008568": "why that happens but I was constantly lying most of my life not only was it", "iECdDFWm-5E-00016-00008568-00009039": "causing more suffering to myself and my mental health but it was also increasing", "iECdDFWm-5E-00017-00009039-00009422": "the suffering of everybody around me since working on my mental health for", "iECdDFWm-5E-00018-00009422-00009882": "the last six years or so it has been so important for me to tell the truth as", "iECdDFWm-5E-00019-00009882-00010497": "much as possible I would be lying to you right now if I told you that I've been a", "iECdDFWm-5E-00020-00010497-00011054": "hundred percent truthful all the time but it is close to I'd say 90 to 95", "iECdDFWm-5E-00021-00011054-00011481": "percent there are still parts of my character that spring up every now and", "iECdDFWm-5E-00022-00011481-00011904": "then for example I was just at the gym and I was actually listening to this", "iECdDFWm-5E-00023-00011904-00012300": "book while at the gym and my best friend he was calling me and I sent him one of", "iECdDFWm-5E-00024-00012300-00012686": "those quick reply messages on the iPhone and it said can't talk right now I'm", "iECdDFWm-5E-00025-00012686-00013115": "working or call or text you later but replied afterwards and I was like hey", "iECdDFWm-5E-00026-00013115-00013515": "man I'm at the gym I just did a quick reply you know what I mean so if I do", "iECdDFWm-5E-00027-00013515-00014079": "catch myself being untruthful like 99% of the time I'm being honest but this", "iECdDFWm-5E-00028-00014079-00014516": "book helped open my eyes about the other little aspects I can really work on to", "iECdDFWm-5E-00029-00014516-00014945": "improve my mental health this is 100% a mental health issue I've", "iECdDFWm-5E-00030-00014945-00015416": "done another video which I will link up in the info card about how long actually", "iECdDFWm-5E-00031-00015416-00015956": "fuels your anxiety like real quick recap on it when you tell a lie you build up", "iECdDFWm-5E-00032-00015956-00016562": "your own stress about are you going to get found lying can also fuel depression", "iECdDFWm-5E-00033-00016562-00017034": "one of the symptoms of depression is a lot of negative self-talk so for example", "iECdDFWm-5E-00034-00017034-00017465": "if you are someone who is constantly lying and deceiving people you are going", "iECdDFWm-5E-00035-00017465-00017870": "to beat yourself up and say I'm no good I am NOT a good person on costly line", "iECdDFWm-5E-00036-00017870-00018504": "fun fact I make half as much money as I used to make because I got out of the", "iECdDFWm-5E-00037-00018504-00019059": "sales industry I knew that I could not do that job and support myself as well", "iECdDFWm-5E-00038-00019059-00019701": "as my son if I was being honest all the time in that industry so this is very", "iECdDFWm-5E-00039-00019701-00020066": "very important I knew that it would make me depressed it would make me too", "iECdDFWm-5E-00040-00020066-00020478": "anxious and for me as a recovering drug addict that can lead me right back to", "iECdDFWm-5E-00041-00020478-00020937": "addiction so before I jump further into this book I really really hope two", "iECdDFWm-5E-00042-00020937-00021429": "things one is that you pick up this book these are the audible version or the", "iECdDFWm-5E-00043-00021429-00021828": "book copy okay the second thing is please share in this video please share", "iECdDFWm-5E-00044-00021828-00022187": "this video so we can work on creating more onus people and have better", "iECdDFWm-5E-00045-00022187-00022466": "communication better relationships and all that good stuff", "iECdDFWm-5E-00046-00022466-00022994": "all right so I'm gonna dive into a few topics from this book first and foremost", "iECdDFWm-5E-00047-00022994-00023504": "let's talk about what is a lie sam harris defines a lie as to intentionally", "iECdDFWm-5E-00048-00023504-00023997": "mislead others when they expect honest communication so he goes into a few", "iECdDFWm-5E-00049-00023997-00024350": "different topics about telling the truth and being truthful the difference", "iECdDFWm-5E-00050-00024350-00024743": "between those two things he also talks about secrets being different than", "iECdDFWm-5E-00051-00024743-00025293": "honesty he also talks about the difference between being deceitful and", "iECdDFWm-5E-00052-00025293-00025766": "lying okay like there's some little nuances in there that I think are very", "iECdDFWm-5E-00053-00025766-00026112": "interesting topics that he covers in this book real quick disclaimer before I", "iECdDFWm-5E-00054-00026112-00026399": "jump to a few of the examples Sam Harris does", "iECdDFWm-5E-00055-00026399-00027013": "a great job of saying even though it is morally correct to be honest as much as", "iECdDFWm-5E-00056-00027013-00027383": "possible you don't got to be a jerk about it okay", "iECdDFWm-5E-00057-00027383-00027863": "so I know people immediately like wow that would be rude to say that he gives", "iECdDFWm-5E-00058-00027863-00028301": "plenty of examples on how to be honest without hurting the other person's", "iECdDFWm-5E-00059-00028301-00028781": "feelings or minimizing the hurt that may be inflicted so the first one let's", "iECdDFWm-5E-00060-00028781-00029152": "cover let's cover the white lie to a friend it's more specifically let's talk", "iECdDFWm-5E-00061-00029152-00029582": "about not being truthful about their skills or their abilities by telling a", "iECdDFWm-5E-00062-00029582-00029882": "lie you are withholding the person's ability", "iECdDFWm-5E-00063-00029882-00030466": "to either a improve upon their skills or abilities or be completely switch paths", "iECdDFWm-5E-00064-00030466-00030944": "this is something I always have to do let's reverse the seats real quick what", "iECdDFWm-5E-00065-00030944-00031489": "I want a bunch of people telling me that my YouTube videos are amazing if they", "iECdDFWm-5E-00066-00031489-00032020": "sucked I might spend so much time and effort on this YouTube channel get no", "iECdDFWm-5E-00067-00032020-00032450": "following at all and be completely confused because nobody was telling me", "iECdDFWm-5E-00068-00032450-00032858": "the truth about my skills and abilities on YouTube now I'm also a writer if you", "iECdDFWm-5E-00069-00032858-00033299": "didn't know I got a couple books up in the Kindle Store now what if nobody ever", "iECdDFWm-5E-00070-00033299-00033719": "told me that I'm a terrible writer this could lead to me spending countless", "iECdDFWm-5E-00071-00033719-00034331": "countless hours some authors spent a ton a ton of time on their books and when", "iECdDFWm-5E-00072-00034331-00034828": "they're requesting feedback from friends colleagues family members if they're", "iECdDFWm-5E-00073-00034828-00035419": "being lied to when we publish that book we might face a ton of criticism and in", "iECdDFWm-5E-00074-00035419-00036005": "some cases we might ruin our reputation because we say things in the wrong way", "iECdDFWm-5E-00075-00036005-00036458": "by the way this is why you have an editor you see what I'm saying like we", "iECdDFWm-5E-00076-00036458-00036875": "can waste countless hours if people aren't honest with us about our skills", "iECdDFWm-5E-00077-00036875-00037384": "and our abilities sure it might hurt at first but what's the alternative", "iECdDFWm-5E-00078-00037384-00037834": "would I rather keep people in my life who I know are lying to me constantly", "iECdDFWm-5E-00079-00037834-00038330": "what else are they lying to me about can I ever value their opinion and this can", "iECdDFWm-5E-00080-00038330-00038711": "be rough like my girlfriend she's an amazing artist by the way follow her on", "iECdDFWm-5E-00081-00038711-00039128": "Instagram and sometimes she'll ask me what I think about her artwork and the", "iECdDFWm-5E-00082-00039128-00039449": "other day she actually asked like oh you know like I think the", "iECdDFWm-5E-00083-00039449-00039890": "proportion on the head is a little bit off but here's where you keep yourself", "iECdDFWm-5E-00084-00039890-00040496": "out of trouble like I am not necessarily her target audience either like I'm not", "iECdDFWm-5E-00085-00040496-00041072": "somebody who values art as much as some people so what I often tell people", "iECdDFWm-5E-00086-00041072-00041480": "especially when they ask me for honest feedback about their craft is I say that", "iECdDFWm-5E-00087-00041480-00042044": "I might not be the best judge of this specific scenario but when you keep", "iECdDFWm-5E-00088-00042044-00042547": "people around who are honest with you it actually improves a relationship because", "iECdDFWm-5E-00089-00042547-00042916": "here's the reason why here is the reason why that I can't", "iECdDFWm-5E-00090-00042916-00043427": "stress enough when that person gives you praise you know they are being honest", "iECdDFWm-5E-00091-00043427-00043943": "with you like for example I make sure to go out of my way to praise my girlfriend", "iECdDFWm-5E-00092-00043943-00044419": "when she makes stunning art that actually I'm just like whoa like I tell", "iECdDFWm-5E-00093-00044419-00044777": "her I'm jealous of her abilities and half the time she's like oh I didn't", "iECdDFWm-5E-00094-00044777-00045088": "even really like that one you know same thing happens to me when", "iECdDFWm-5E-00095-00045088-00045602": "you all actually like a video that I didn't think much of but I give praise", "iECdDFWm-5E-00096-00045602-00046178": "left and right and it lifts people's spirits up because they know that I'm", "iECdDFWm-5E-00097-00046178-00046649": "always being truthful with them next should you ever lie about an illness to", "iECdDFWm-5E-00098-00046649-00047069": "your friends and family members if you're somebody who has lost somebody in", "iECdDFWm-5E-00099-00047069-00047471": "your life maybe it's your parents grandparents friends whoever it is if", "iECdDFWm-5E-00100-00047471-00047924": "you've lost anybody to an illness that you did not see coming that they knew", "iECdDFWm-5E-00101-00047924-00048218": "about you already know the answer to this question I've personally been", "iECdDFWm-5E-00102-00048218-00048599": "dealing with this with my own father he's had some health issues since last", "iECdDFWm-5E-00103-00048599-00049153": "year last year the day of my birthday he had an open heart surgery and ever since", "iECdDFWm-5E-00104-00049153-00049694": "then like myself my sister my family we've all kind of been on edge my dad", "iECdDFWm-5E-00105-00049694-00050468": "has this ability to minimize everything okay and I told him is that you'd be", "iECdDFWm-5E-00106-00050468-00050882": "honest with me like why do you tell me if your health is deteriorating", "iECdDFWm-5E-00107-00050882-00051391": "then the hurt that I would feel by being completely caught off guard from you", "iECdDFWm-5E-00108-00051391-00051836": "dying and you knew that this was coming but you didn't tell me when we lie to", "iECdDFWm-5E-00109-00051836-00052400": "our loved ones about our health issues we are denying them the ability to show", "iECdDFWm-5E-00110-00052400-00053005": "us love and affection we are stripping them of that right and now the worst", "iECdDFWm-5E-00111-00053005-00053735": "question of them all that we all get at some point or another do I look fat now", "iECdDFWm-5E-00112-00053735-00054127": "Sam Harris brings up an excellent point when discussing this one he talks about", "iECdDFWm-5E-00113-00054127-00054548": "like the chances are that you know your audience you know your audience very", "iECdDFWm-5E-00114-00054548-00054902": "well what I mean by that is chances are you're not just walking down the street", "iECdDFWm-5E-00115-00054902-00055291": "and some random strangers gonna be like do I look fat like that never happened", "iECdDFWm-5E-00116-00055291-00055754": "so think about who your audience is for example is it your wife or husband", "iECdDFWm-5E-00117-00055754-00056129": "boyfriend girlfriend isn't one of these people okay something I often try to do", "iECdDFWm-5E-00118-00056129-00056576": "is like that's like what's the root what's the root of this question or they", "iECdDFWm-5E-00119-00056576-00057041": "just ask me if I love them or they ask me if I love them unconditionally right", "iECdDFWm-5E-00120-00057041-00057508": "are they asking me if I'm attracted to them or are they asking because they've", "iECdDFWm-5E-00121-00057508-00057932": "had some health issues lately or the doctor said something you know what I'm", "iECdDFWm-5E-00122-00057932-00058429": "saying like this helps me gauge my response to it and like for example I", "iECdDFWm-5E-00123-00058429-00058940": "going back to this whole role reversal thing anybody on planet Earth", "iECdDFWm-5E-00124-00058940-00059489": "ever came up to me and said Chris you're not overweight I would never ever ever", "iECdDFWm-5E-00125-00059489-00060062": "ever trust a single word that came out of their mouths like they are blatantly", "iECdDFWm-5E-00126-00060062-00060482": "lying to your face and as humans we wonder what else are they lying about", "iECdDFWm-5E-00127-00060482-00061001": "again disclaimer when answering this question honestly you don't have to be a", "iECdDFWm-5E-00128-00061001-00061454": "jerk about it another person who might ask you this is it like a friend right", "iECdDFWm-5E-00129-00061454-00061829": "is it a friend is it a family member you know them very well is this somebody who", "iECdDFWm-5E-00130-00061829-00062240": "is desperately looking for a relationship are they on the path to", "iECdDFWm-5E-00131-00062240-00062627": "trying to get married and start a family and are they asking you does this outfit", "iECdDFWm-5E-00132-00062627-00063082": "make me look fat right well again going back to the skills and abilities", "iECdDFWm-5E-00133-00063082-00063476": "question on should you lie to them like are you going to let your friend walk", "iECdDFWm-5E-00134-00063476-00064004": "out in public looking awful when they're trying to find a potential partner are", "iECdDFWm-5E-00135-00064004-00064373": "you really helping them or are you hurting them in this situation but", "iECdDFWm-5E-00136-00064373-00064954": "another way of talking to somebody about this is like this hey it's completely up", "iECdDFWm-5E-00137-00064954-00065447": "to you on who you're looking for yes there are men or women who prefer a", "iECdDFWm-5E-00138-00065447-00065801": "different type of physique than what you have so if you're looking for that type", "iECdDFWm-5E-00139-00065801-00066500": "of person then yeah maybe you might want to lose some weight but about that", "iECdDFWm-5E-00140-00066500-00066917": "empowerment though like I tell people straight up I'm like listen there are", "iECdDFWm-5E-00141-00066917-00067628": "people who might like your size right like that's totally correct and like", "iECdDFWm-5E-00142-00067628-00068231": "realtalk if you are looking for somebody who is purely only going to date you", "iECdDFWm-5E-00143-00068231-00068768": "based on your weight maybe they aren't the best person for you you know what", "iECdDFWm-5E-00144-00068768-00069197": "I'm saying so I'm very honest when it comes to even the topic of weight and", "iECdDFWm-5E-00145-00069197-00069506": "these are ways that you can talk about it in a safe way and is the person", "iECdDFWm-5E-00146-00069506-00069929": "talking to you or asking you about your weight because they're trying to get a", "iECdDFWm-5E-00147-00069929-00070319": "beachbody you know what I'm saying like again are they looking for a potential", "iECdDFWm-5E-00148-00070319-00070784": "mate I'd also ask like are they comfortable with their body because you", "iECdDFWm-5E-00149-00070784-00071192": "know truth be told if they're comfortable with their body do you think", "iECdDFWm-5E-00150-00071192-00071882": "go for yourself on the beach or at the pool like it's that simple like are you", "iECdDFWm-5E-00151-00071882-00072419": "happy with you anybody ever ask me about weight it's like are you comfortable", "iECdDFWm-5E-00152-00072419-00072920": "with yourself if not if you're not comfortable going out and you know a", "iECdDFWm-5E-00153-00072920-00073412": "bikini or a speedo or even like a bathing suit then yeah maybe you should", "iECdDFWm-5E-00154-00073412-00073922": "lose some weight so lastly women is it morally okay to lie basically what I", "iECdDFWm-5E-00155-00073922-00074533": "love about this book is Sam Harris literally suffocates every excuse to lie", "iECdDFWm-5E-00156-00074533-00075113": "except in two scenarios the first one is like a life-and-death situation okay", "iECdDFWm-5E-00157-00075113-00075542": "like if you're in war or if like a murderer is in your house or like just", "iECdDFWm-5E-00158-00075542-00076076": "crazy scenarios like that right like yes then it's okay to lie to preserve life", "iECdDFWm-5E-00159-00076076-00076736": "the other example that he talks about is if you lie would it do more harm than", "iECdDFWm-5E-00160-00076736-00077246": "good and the example given in this book is say a guy cheated on his wife years", "iECdDFWm-5E-00161-00077246-00077630": "ago okay he stopped the affair everything with his wife and his", "iECdDFWm-5E-00162-00077630-00078014": "children is going great and now he wants to be honest should he tell his wife", "iECdDFWm-5E-00163-00078014-00078608": "about the affair the answer being no okay reason being is because a lot of", "iECdDFWm-5E-00164-00078608-00079055": "people can be affected two marriages are involved right that persons as well as", "iECdDFWm-5E-00165-00079055-00079553": "the person he had a affair with also the kids lives are involved too so this is", "iECdDFWm-5E-00166-00079553-00079907": "something I often teach my clients too because sometimes we tell the truth just", "iECdDFWm-5E-00167-00079907-00080336": "to clear our own conscience and we don't think about the damage it can do to", "iECdDFWm-5E-00168-00080336-00080834": "other people if any of you are familiar with step 9 from 12-step programs you", "iECdDFWm-5E-00169-00080834-00081230": "know a lot more about this subject and basically what sam harris says as an", "iECdDFWm-5E-00170-00081230-00081640": "answer to this is if this is the new way of living that you're trying to have", "iECdDFWm-5E-00171-00081640-00082130": "start moving forward okay moving forward with this honesty so he", "iECdDFWm-5E-00172-00082130-00082616": "also covers a variety of other topics in this book like is it okay to lie to", "iECdDFWm-5E-00173-00082616-00083006": "children should you lie job interviews when you're desperate for a job and a", "iECdDFWm-5E-00174-00083006-00083423": "really interesting what I found is should you lie to somebody about", "iECdDFWm-5E-00175-00083423-00083825": "throwing them a surprise party this was very very interesting I really enjoyed", "iECdDFWm-5E-00176-00083825-00084194": "his answer on this one so Sam basically says the golden rule this is the golden", "iECdDFWm-5E-00177-00084194-00084728": "rule that I stand by as well is if the walls were reversed would you rather the", "iECdDFWm-5E-00178-00084728-00085235": "truth be told to you or along if you use that as your North Star or your rule of", "iECdDFWm-5E-00179-00085235-00085841": "thumb you will be set up for success and better relationships with others as well", "iECdDFWm-5E-00180-00085841-00086234": "as yourself and your mental health again please share this video please share", "iECdDFWm-5E-00181-00086234-00086617": "this video so other people could start reevaluating the way they look at line", "iECdDFWm-5E-00182-00086617-00087080": "even white lies okay and if you want to check out this book is down in the", "iECdDFWm-5E-00183-00087080-00087506": "description below along with my entire mental health reading list alright but", "iECdDFWm-5E-00184-00087506-00087818": "here's the question of the day I think this will be fun Sam Harris did this at", "iECdDFWm-5E-00185-00087818-00088193": "the end of his book this is something I do with my clients leave comments down", "iECdDFWm-5E-00186-00088193-00088760": "below I want you to give me scenarios in which you think it's okay to lyin let's", "iECdDFWm-5E-00187-00088760-00089072": "discuss I'm really interested to see what you all say but anyways anyways", "iECdDFWm-5E-00188-00089072-00089420": "thank you so much for watching if you like this video please give it a thumbs", "iECdDFWm-5E-00189-00089420-00089771": "up and if you are new here I'm always making videos to help you out with your", "iECdDFWm-5E-00190-00089771-00090098": "mental and emotional health click that little right subscribe button right", "iECdDFWm-5E-00191-00090098-00090425": "there if you want check out some other videos on this channel you can click or", "iECdDFWm-5E-00192-00090425-00090853": "tap on one of those thumbnails okay so again thanks so much for watching", "iECdDFWm-5E-00193-00090853-00091423": "Quitline today and I'll see you next on"}}, {"audio_id": "iEC-CfqQS7y", "text": {"iEC-CfqQS7y-00000-00000075-00000379": "The specialty rotations at Kaiser are really unique", "iEC-CfqQS7y-00001-00000379-00000750": "because they encompass several different practice settings.", "iEC-CfqQS7y-00002-00000750-00000992": "It's partially inpatient, partially outpatient", "iEC-CfqQS7y-00003-00000992-00001358": "and partially remote review of complex cases.", "iEC-CfqQS7y-00004-00001358-00001655": "We have hundreds of thousands of patients in our region.", "iEC-CfqQS7y-00005-00001655-00002053": "And so it's not left up to chance whether you'll see an unusually", "iEC-CfqQS7y-00006-00002053-00002326": "complex case, a rare case.", "iEC-CfqQS7y-00007-00002326-00002743": "Our specialty rotations offer a diverse population of patients and", "iEC-CfqQS7y-00008-00002743-00003111": "socioeconomic class, ethnicity, as well as diseases.", "iEC-CfqQS7y-00009-00003111-00003265": "We see everything.", "iEC-CfqQS7y-00010-00003265-00003768": "From common diseases to rare diseases, you're really going to see the entire spectrum.", "iEC-CfqQS7y-00011-00003768-00004173": "One of the things that Kaiser emphasizes is coordination of care.", "iEC-CfqQS7y-00012-00004173-00004503": "There is a lot that goes on in the specialty settings,", "iEC-CfqQS7y-00013-00004503-00004826": "that needs to be communicated to the primary care setting.", "iEC-CfqQS7y-00014-00004826-00005271": "And also communicating with non-physician practitioners,", "iEC-CfqQS7y-00015-00005271-00005712": "diabetes educators, nurse educators, case managers, nurse navigators.", "iEC-CfqQS7y-00016-00005712-00006021": "You're going to see the value of our integrated care model.", "iEC-CfqQS7y-00017-00006021-00006376": "Cancer patients are so complicated, we have to include pulmonary and", "iEC-CfqQS7y-00018-00006376-00006692": "radiology and intensive care, the hospitalists,", "iEC-CfqQS7y-00019-00006692-00007136": "you will see how top-notch medical system works altogether.", "iEC-CfqQS7y-00020-00007136-00007578": "Our geriatrics program is set up to see and observe patients", "iEC-CfqQS7y-00021-00007578-00007950": "as they transition through the hospital, the rehab,", "iEC-CfqQS7y-00022-00007950-00008318": "the nursing home, etcetera, but also so that we can think", "iEC-CfqQS7y-00023-00008318-00008592": "about them in terms of their medical conditions and their", "iEC-CfqQS7y-00024-00008592-00009009": "socioeconomic conditions and their spiritual conditions.", "iEC-CfqQS7y-00025-00009009-00009333": "And that's a lot of what Kaiser does, multiple practitioners,", "iEC-CfqQS7y-00026-00009333-00009597": "doctors and non-doctors thinking about these", "iEC-CfqQS7y-00027-00009597-00009825": "complex patients in a holistic way.", "iEC-CfqQS7y-00028-00009825-00010175": "It really translates to better care for the patient", "iEC-CfqQS7y-00029-00010176-00010418": "and fabulous education.", "iEC-CfqQS7y-00030-00010418-00010800": "We love working with residents here.", "iEC-CfqQS7y-00031-00010800-00011278": "What you're getting is a really dedicated group of faculty", "iEC-CfqQS7y-00032-00011278-00011496": "who are just passionate educators.", "iEC-CfqQS7y-00033-00011496-00011727": "We love finding out who you are and what,", "iEC-CfqQS7y-00034-00011727-00011894": "where you want to go, what you want to do,", "iEC-CfqQS7y-00035-00011894-00012062": "and just trying to get you there."}}, {"audio_id": "iEJbkFv2zMc", "text": {"iEJbkFv2zMc-00000-00001117-00001513": "Item #: SCP-016-J", "iEJbkFv2zMc-00001-00001513-00001719": "Object Class: Euclid", "iEJbkFv2zMc-00002-00001719-00002403": "Standard Containment Procedures: SCP-016-J is to be kept in an armory with other explosive", "iEJbkFv2zMc-00003-00002403-00003284": "devices, all of which must be smaller than SCP-016-J. Use of SCP-016-J outside of testing", "iEJbkFv2zMc-00004-00003284-00003453": "is prohibited.", "iEJbkFv2zMc-00005-00003453-00004043": "Conversation is (whilst not encouraged) permitted.", "iEJbkFv2zMc-00006-00004043-00004778": "Description: SCP-016-J is a ballistic missile approximately 2.4 meters tall and 0.3 meters", "iEJbkFv2zMc-00007-00004778-00004953": "in diameter.", "iEJbkFv2zMc-00008-00004953-00005529": "Rude comments have been spray painted on all parts of SCP-016-J, obscuring the original", "iEJbkFv2zMc-00009-00005529-00005692": "paint job.", "iEJbkFv2zMc-00010-00005692-00006389": "These comments include \"Cock Block This!\" and \"I hear you like it rough\".", "iEJbkFv2zMc-00011-00006389-00006923": "SCP-016-J is capable of telepathic communication with any living being within four meters.", "iEJbkFv2zMc-00012-00006923-00007350": "While researchers have been reluctant to give interviews, information from said interviews", "iEJbkFv2zMc-00013-00007350-00007822": "suggests SCP-016-J is both sapient and sentient.", "iEJbkFv2zMc-00014-00007822-00008550": "SCP-016-J insists on being used in battle, and claims \"to have been on the front lines", "iEJbkFv2zMc-00015-00008550-00008822": "many times\".", "iEJbkFv2zMc-00016-00008822-00009504": "Addendum SCP-016-J-1: Below is a partial transcript from an interview with SCP-016-J.", "iEJbkFv2zMc-00017-00009504-00009802": "SCP-016-J: C’mon doc.", "iEJbkFv2zMc-00018-00009802-00009902": "Just fire me.", "iEJbkFv2zMc-00019-00009902-00010060": "You know I’ll satisfy you.", "iEJbkFv2zMc-00020-00010060-00010302": "Dr. Teller: We’re not going to use you.", "iEJbkFv2zMc-00021-00010302-00010511": "We’re not fighting any wars or anything.", "iEJbkFv2zMc-00022-00010511-00010781": "SCP-016-J: Oh, I think you’re just scared.", "iEJbkFv2zMc-00023-00010781-00011033": "You’re afraid because I’m the biggest missile you’ve ever seen.", "iEJbkFv2zMc-00024-00011033-00011364": "You don’t know how much I’m going to hurt.", "iEJbkFv2zMc-00025-00011364-00011464": "But you can do it.", "iEJbkFv2zMc-00026-00011464-00011711": "I’ve seen your silos, just waiting for me.", "iEJbkFv2zMc-00027-00011711-00011811": "I’ll fit.", "iEJbkFv2zMc-00028-00011811-00012031": "Dr. Teller: But you’re not even that big…", "iEJbkFv2zMc-00029-00012031-00012238": "SCP-016-J: What do you mean?", "iEJbkFv2zMc-00030-00012238-00012338": "I’m huge!", "iEJbkFv2zMc-00031-00012338-00012760": "Dr. Teller: No, I’ve totally seen— never mind.", "iEJbkFv2zMc-00032-00012760-00013012": "Yes, you’re the biggest missile I’ve ever seen.", "iEJbkFv2zMc-00033-00013012-00013271": "SCP-016-J: So just aim me toward the battle field.", "iEJbkFv2zMc-00034-00013271-00013558": "I just want to explode all over some trenches.", "iEJbkFv2zMc-00035-00013558-00013802": "Dr. Teller: Ok, that’s it.", "iEJbkFv2zMc-00036-00013802-00013963": "I’m ending this interview.", "iEJbkFv2zMc-00037-00013963-00014143": "SCP-016-J: No, don’t stop.", "iEJbkFv2zMc-00038-00014143-00014379": "Talk ballistic to me.", "iEJbkFv2zMc-00039-00014379-00015200": "Addendum SCP-016-J-2: After continued insistence from SCP-016-J, and agreement from researchers", "iEJbkFv2zMc-00040-00015200-00015959": "that SCP-016-J's destruction would improve workplace morale, a test of firing SCP-016-J", "iEJbkFv2zMc-00041-00015959-00016326": "was conducted.", "iEJbkFv2zMc-00042-00016326-00016690": "SCP-016-J was aimed at a target 100km away and fired.", "iEJbkFv2zMc-00043-00016690-00017579": "During the flight, SCP-016-J greatly reduced in size, measuring 0.5m long, and 0.15m in", "iEJbkFv2zMc-00044-00017579-00017865": "diameter two seconds after launch.", "iEJbkFv2zMc-00045-00017865-00018334": "Upon impact, SCP-016-J failed to explode.", "iEJbkFv2zMc-00046-00018334-00018948": "When questioned about the test results, SCP-016-J responded, \"this never happens to me\"."}}, {"audio_id": "iG06AFuxSKU", "text": {"iG06AFuxSKU-00000-00000000-00000168": "asalam alykum wr wb", "iG06AFuxSKU-00001-00000168-00000584": "hello guys welcome to the channel hope you're having yourself a wonderful day in today's video", "iG06AFuxSKU-00002-00000584-00001304": "we'll be reacting to another tni video this video was suggested by eki risky fernanda stay tuned", "iG06AFuxSKU-00003-00001304-00001664": "we're going to get started with that video in just a couple of minutes uh for those of you who are", "iG06AFuxSKU-00004-00001664-00002016": "new and who happen to come across this channel and this video for the first time i'd like to", "iG06AFuxSKU-00005-00002016-00002416": "take a moment and welcome you guys to the channel i upload videos every day so if you guys like the", "iG06AFuxSKU-00006-00002416-00002824": "content as well as the channel and want to be part of this journey then please consider subscribing", "iG06AFuxSKU-00007-00002824-00003176": "to the channel and turning notification on so you're notified when a new video is uploaded", "iG06AFuxSKU-00008-00003176-00004736": "stay tuned guys we'll be right back welcome back guys we're gonna get started with the", "iG06AFuxSKU-00009-00004736-00005104": "video momentarily and at the end of the video i'll be sharing with you my observation reaction", "iG06AFuxSKU-00010-00005104-00005784": "so please make sure you stay until the end and with that said let's get started with our video", "iG06AFuxSKU-00011-00041728-00042376": "it was interesting guys so that was i guess their training for supporting like uh or escorting uh", "iG06AFuxSKU-00012-00042376-00042792": "vips so for example in this case they had somebody that looked like i believe the prime", "iG06AFuxSKU-00013-00042792-00043360": "minister or the president of uh indonesia and you know their show and they take him out and", "iG06AFuxSKU-00014-00043360-00043848": "something happened so how are they able to take him out of the scene uh but overall like it was", "iG06AFuxSKU-00015-00043848-00044288": "really really interesting they're shooting the targets i thought the guys were holding the", "iG06AFuxSKU-00016-00044288-00044664": "targets where they were going to actually hold it in front of themselves i was like whoa that's too", "iG06AFuxSKU-00017-00044664-00045112": "much what if they missed but they were actually putting it on the side and they put the balloons", "iG06AFuxSKU-00018-00045168-00045752": "and then they put balloon behind each side and they basically went and they were turning around", "iG06AFuxSKU-00019-00045752-00046216": "which was really really cool because they were working as a team and you know they", "iG06AFuxSKU-00020-00046216-00046680": "got rid of all the balloons and then they showed basically that the vip that they were", "iG06AFuxSKU-00021-00046784-00047264": "supporting or escorting which was really really cool these guys are pretty talented i guess these", "iG06AFuxSKU-00022-00047264-00047880": "are like the the cream of the crop or the top as you can see you can see based on their skill", "iG06AFuxSKU-00023-00047880-00048384": "that mashallah they're really really talented just on point and i think that's why indonesia in like", "iG06AFuxSKU-00024-00048384-00048976": "11 or 12 years consecutively have been winning the shooting competition which we did react to", "iG06AFuxSKU-00025-00048976-00049456": "the last one was in australia i believe so really really interesting guys i really really liked it i", "iG06AFuxSKU-00026-00049456-00049784": "hope you did too if you did please don't forget to like comment share and subscribe and if you", "iG06AFuxSKU-00027-00049784-00050120": "want me to check out another video please put a comment section below as always thank", "iG06AFuxSKU-00028-00050120-00050528": "you very much guys for all you love and support terry marquez i hope you guys have yourself a", "iG06AFuxSKU-00029-00050528-00051984": "wonderful day take care yourself and your family inshallah i'll see you guys tomorrow take care and wassalam"}}, {"audio_id": "iGBeJKNyIII", "text": {"iGBeJKNyIII-00000-00000052-00000602": "CINAHL is a great database to search when you're looking for issues related to the communication sciences and disorders", "iGBeJKNyIII-00001-00000673-00001043": "CINAHL stands for the cumulative index of allied health and nursing.", "iGBeJKNyIII-00002-00001108-00001853": "Now you know why everyone uses the acronym we're going to cover how to run a basic search end up beyond the basic search how", "iGBeJKNyIII-00003-00001853-00002090": "To use the limiters and how to use cinahl headings", "iGBeJKNyIII-00004-00002160-00002504": "CINAHL is wonderful because you can search it in so many different ways", "iGBeJKNyIII-00005-00002553-00003170": "But it can also be confusing for the exact same reason especially for those of you just starting out", "iGBeJKNyIII-00006-00003171-00003609": "I'm going to show you a few different ways to search and you can use method that works for you", "iGBeJKNyIII-00007-00003610-00003861": "There are several ways to get to the CINAHL database", "iGBeJKNyIII-00009-00004973-00005502": "The first way we're going to search is to just put a word or two into the search box that matches our topic", "iGBeJKNyIII-00010-00005503-00005866": "I'm going to look for information on the use of alternative augmentative communication", "iGBeJKNyIII-00011-00005951-00006198": "for children with autism spectrum disorders", "iGBeJKNyIII-00012-00006218-00006777": "So I'm just going to type in alternative augmentative communication and autism", "iGBeJKNyIII-00013-00006865-00007494": "Honestly, this isn't a very good search but we're going to use some of the tools within cinahl to make it much better first", "iGBeJKNyIII-00014-00007495-00008011": "You're going to want to browse through the initial results. We only have ten here. That's not that much", "iGBeJKNyIII-00015-00008011-00008194": "We definitely want to have more than that", "iGBeJKNyIII-00016-00008194-00008757": "But even a less than stellar search will usually bring up one to two articles that are close to what you want", "iGBeJKNyIII-00017-00008831-00009211": "Let's see if any of these sort of match my search it looks like", "iGBeJKNyIII-00018-00009275-00009708": "Number three will be a pretty good match. So I'm gonna go ahead and click on the link", "iGBeJKNyIII-00019-00009709-00010311": "This is the individual journal articles record. There's a lot going on on this page", "iGBeJKNyIII-00020-00010315-00010515": "There is a really long title", "iGBeJKNyIII-00021-00010522-00011220": "You have all the author's listed where they come from the source information, which is the journal and all the details about that", "iGBeJKNyIII-00022-00011264-00011925": "What sort of publication, type what language it is. The one thing you're really looking for. Here is the major subject", "iGBeJKNyIII-00023-00011925-00012483": "These are the subject headings that have been assigned to this journal article. They represent what the article is about", "iGBeJKNyIII-00024-00012505-00012948": "They don't always match what you type in and sometimes they can be a little weird", "iGBeJKNyIII-00025-00012948-00013563": "But you can use these to expand your search. Just click on one that matches your topic. They don't use the term", "iGBeJKNyIII-00026-00013628-00013828": "alternative augmentative communication", "iGBeJKNyIII-00027-00013853-00014238": "They seem to be using the term communication aids for disabled", "iGBeJKNyIII-00028-00014258-00014892": "So in order to search on that, all I have to do is click on the link. Okay this brings up", "iGBeJKNyIII-00029-00014959-00015687": "669 articles that are classified under the communication aids for the disabled now that's only searching on one of my", "iGBeJKNyIII-00030-00015716-00016350": "concepts. To search on the other one, autism, I'm going to go ahead and go back to that original article", "iGBeJKNyIII-00031-00016351-00017139": "Now they have the subject heading autistic disorder. They also have what's called a subheading or something that focuses that of", "iGBeJKNyIII-00032-00017204-00017887": "Psychosocial factors. I don't really want that aspect of the search, so I'm certainly going to click on autistic disorder", "iGBeJKNyIII-00033-00017906-00018674": "Okay, that brings up over 7,000 articles on just autistic disorder, but that is searching just on autistic", "iGBeJKNyIII-00034-00018674-00018810": "It's not", "iGBeJKNyIII-00035-00018810-00019246": "Incorporating the communication aids for the disabled now, we want to combine our searches", "iGBeJKNyIII-00036-00019247-00019508": "This is one of the things I like the most about", "iGBeJKNyIII-00037-00019524-00020041": "Cinahl is that it's very visual and is really easy to combine and work with your searches", "iGBeJKNyIII-00038-00020043-00020596": "They have this section here at the top that's called their search history and alerts. It will list out", "iGBeJKNyIII-00039-00020628-00020775": "Everything you've searched on", "iGBeJKNyIII-00040-00020775-00021316": "Can be really handy especially if you start to get lost in your searches or you want to combine any searches", "iGBeJKNyIII-00041-00021318-00022001": "So I want to combine my communication aids for the disabled and autistic disorder to do that", "iGBeJKNyIII-00042-00022001-00022360": "I just have to click in the check boxes next to each term and", "iGBeJKNyIII-00043-00022377-00022858": "I get the option of to Search with AND to search with OR or Delete Searches", "iGBeJKNyIII-00044-00022859-00023429": "I definitely don't want that to Search with OR is asking the database just to look for either", "iGBeJKNyIII-00045-00023493-00023676": "autistic disorders or", "iGBeJKNyIII-00046-00023676-00024286": "Communication aids for the disabled not where they appear together if you want articles where the both of them appear together", "iGBeJKNyIII-00047-00024321-00024521": "you want to \"Search with AND.\"", "iGBeJKNyIII-00048-00024546-00025189": "Ok that expands our search a little bit from our original ten to thirty four. That's still not a ton", "iGBeJKNyIII-00049-00025190-00025481": "But at least it's a few more the next step is", "iGBeJKNyIII-00050-00025503-00026092": "to either look through what you want when you only have 34 articles you certainly can look through all of them or you", "iGBeJKNyIII-00051-00026120-00026452": "Can actually go to the side on the left hand side", "iGBeJKNyIII-00052-00026452-00026905": "they have all of the limiters if you want to apply any of those now you can but again", "iGBeJKNyIII-00053-00026916-00027036": "It's just 34", "iGBeJKNyIII-00054-00027036-00027289": "You generally don't need to okay", "iGBeJKNyIII-00055-00027306-00027506": "So that is search method number one", "iGBeJKNyIII-00056-00027525-00027848": "Where we start with some keywords or words that we come up with?", "iGBeJKNyIII-00057-00027855-00028360": "Find a good article and then build our search with the subject headings from that article", "iGBeJKNyIII-00058-00028361-00028916": "It's not a bad way to search but it can be a little complicated right? Let's try another method", "iGBeJKNyIII-00059-00028974-00029566": "Searching using the CINAHL headings. CINAHL has a great searching feature called CINAHL headings", "iGBeJKNyIII-00060-00029604-00030076": "These are the subject headings that CINAHL uses to categorize the articles in the database", "iGBeJKNyIII-00061-00030123-00030775": "You can actually search these using just keywords or the words that you come up with in order to get to this database", "iGBeJKNyIII-00062-00030804-00031214": "You just have to come up to the top and click on CINAHL headings now", "iGBeJKNyIII-00063-00031214-00031621": "You can type in any term that you want to let's say I want to look into stutter", "iGBeJKNyIII-00064-00031652-00032289": "I'm just going to type in stuttering. Now nothing came up for stuttering, but something did come up for fluency disorders", "iGBeJKNyIII-00065-00032371-00032790": "That means that CINAHL doesn't use the word stuttering as a subject heading", "iGBeJKNyIII-00066-00032821-00033465": "They actually classify it as fluency disorders if you're not sure if that's actually the term that you want", "iGBeJKNyIII-00067-00033496-00033816": "You can come over here to the little yellow note", "iGBeJKNyIII-00068-00033836-00034512": "This is called a scope note click on that and it will tell you what this term encompasses", "iGBeJKNyIII-00069-00034537-00034612": "So yes", "iGBeJKNyIII-00070-00034612-00034812": "That does look like stuttering would be included in that", "iGBeJKNyIII-00071-00034846-00035106": "but to actually go back and search on it and", "iGBeJKNyIII-00072-00035119-00035820": "All you need to do is click the little box next to the term and we're going to move from left to right", "iGBeJKNyIII-00073-00035912-00036334": "From here you can choose to explode this is not an option in our case", "iGBeJKNyIII-00074-00036352-00036475": "but if there were more", "iGBeJKNyIII-00075-00036475-00037140": "Specific terms within fluency disorder clicking on the explode term would search those. You can also search where it's the major", "iGBeJKNyIII-00076-00037165-00037452": "Concept which could be handy if your search is very broad", "iGBeJKNyIII-00077-00037456-00038163": "But generally I don't select that at first just because it can over narrow my search this last option over here on the far", "iGBeJKNyIII-00078-00038163-00038715": "right is one of the reasons I love searching in CINAHL headings, because you can limit to", "iGBeJKNyIII-00079-00038771-00039198": "Subheadings which can really make your search so much more specific and focused", "iGBeJKNyIII-00080-00039281-00039801": "There are a lot of subheadings here and some of them aren't going to make a lot of sense for some of your terms", "iGBeJKNyIII-00081-00039833-00040369": "We are actually going to look just on the therapy that's going to be one of the ones to use the most", "iGBeJKNyIII-00082-00040424-00041016": "Alright, so I selected the subheading therapy that shows up here my search term", "iGBeJKNyIII-00083-00041016-00041439": "all I need to do now is search the database. Now, I have", "iGBeJKNyIII-00084-00041552-00042141": "487 articles that are specific to fluency disorders in the therapy of fluency disorders", "iGBeJKNyIII-00085-00042206-00042591": "All right. So this search brought up quite a few more than our last ones", "iGBeJKNyIII-00086-00042591-00043158": "so this is when you start applying some of the limiters that are here on the left hand side. A limiter is something that makes", "iGBeJKNyIII-00087-00043158-00043803": "Your search more specific. It gives you less results, which sometimes can be a good thing because you definitely don't want to go through", "iGBeJKNyIII-00088-00043888-00044460": "487 results so let's say the first one I want to do is I want it only within", "iGBeJKNyIII-00089-00044531-00044731": "maybe the last four years.", "iGBeJKNyIII-00090-00044833-00045240": "Okay, we've limited by date. You could also limit it to let's say we only want", "iGBeJKNyIII-00091-00045344-00045726": "academic journals you can limit to major headings", "iGBeJKNyIII-00092-00045842-00046438": "Again, those are some of the subject headings you can limit to a particular journal a particular age", "iGBeJKNyIII-00093-00046438-00046701": "Which can be really handy if you want", "iGBeJKNyIII-00094-00046748-00047109": "These are the primary a limiter there are additional ones", "iGBeJKNyIII-00095-00047110-00047574": "If you click on show more you can limit to let's say we only want preschool", "iGBeJKNyIII-00096-00047645-00047854": "Let's update that we went from", "iGBeJKNyIII-00097-00047906-00048331": "several hundred results down to sixteen just by clicking a few", "iGBeJKNyIII-00098-00048380-00048538": "limiters over on the left-hand side", "iGBeJKNyIII-00099-00048538-00048933": "If you ever get to the point where you have too few results", "iGBeJKNyIII-00100-00048968-00049519": "Then you can start going in and clicking on the little blue X's and those will take your limiters out", "iGBeJKNyIII-00101-00049628-00050104": "Okay, so our second method was to search using the CINAHL headings", "iGBeJKNyIII-00102-00050159-00050509": "This is a pretty easy way to search and it's fairly intuitive", "iGBeJKNyIII-00103-00050552-00050875": "The final search method is to go to the advanced search", "iGBeJKNyIII-00104-00050914-00051361": "Now just because it's called advanced search doesn't mean that you can't do it", "iGBeJKNyIII-00105-00051413-00051736": "Sometimes the advanced search is actually easier to use.", "iGBeJKNyIII-00106-00051764-00052546": "In this case you have multiple boxes. So you can separate out your search terms and then you have all these options down here", "iGBeJKNyIII-00107-00052546-00053041": "That's a lot to choose from. I'm just going to point out the ones that will be most helpful for you", "iGBeJKNyIII-00108-00053045-00053533": "The only one I'll focus on here on the left hand side is the special interest", "iGBeJKNyIII-00109-00053542-00054222": "You'll see if you scroll down that there is a special interest category for speech-language pathology and audiology", "iGBeJKNyIII-00110-00054280-00054561": "This means that we could run a search on any topic", "iGBeJKNyIII-00111-00054587-00055266": "say stroke and the database will only bring up articles on stroke that have been classified as fitting into the", "iGBeJKNyIII-00112-00055283-00055824": "SLP or audiology category pretty cool on the right hand side you can limit to", "iGBeJKNyIII-00113-00055891-00056157": "Year, so let's say we want the last ten years", "iGBeJKNyIII-00114-00056261-00056450": "You can limit to a particular", "iGBeJKNyIII-00115-00056450-00056736": "publication if you're there's just one journal that you want to search", "iGBeJKNyIII-00116-00056779-00057438": "You can select peer-reviewed very nice option as many your professors specifically ask you to look for peer-reviewed", "iGBeJKNyIII-00117-00057442-00057921": "There are certainly a lot of other things a particular journal subset", "iGBeJKNyIII-00118-00057983-00058183": "languages you can limit to", "iGBeJKNyIII-00119-00058229-00058735": "men or women. You can limit to inpatients. Age group is really handy", "iGBeJKNyIII-00120-00058782-00059134": "Let's say we're looking on stroke and we want it in", "iGBeJKNyIII-00121-00059201-00059325": "maybe", "iGBeJKNyIII-00122-00059325-00059572": "younger adults 19 to 44 years old", "iGBeJKNyIII-00123-00059625-00060295": "You can even limit to the number of pages and I think that's all a limit for now. I will go back up", "iGBeJKNyIII-00124-00060295-00060784": "I'll type stroke in here and we'll search if you look over here on the left hand side", "iGBeJKNyIII-00125-00060795-00061408": "Tells you how you've searched what you've searched and how you searched in this case. It says I have searched on stroke", "iGBeJKNyIII-00126-00061437-00061862": "It shows me all of my limiters and in the middle section we have", "iGBeJKNyIII-00127-00061941-00062204": "253 articles that's a good amount", "iGBeJKNyIII-00128-00062204-00062767": "But it's not a huge number to have to go through and chances are you'll find what you want on the first few pages anyway", "iGBeJKNyIII-00129-00062792-00063407": "The final step in a CINAHL search is looking through what you find to select the articles that were worked for your research", "iGBeJKNyIII-00130-00063462-00064003": "CINAHL has a feature where you can add things to a folder which can help you. Keep track of your information", "iGBeJKNyIII-00131-00064026-00064309": "So you look for the articles that look relevant", "iGBeJKNyIII-00132-00064314-00064804": "Click on the little blue folder and this will add things to your CINAHL folder", "iGBeJKNyIII-00133-00064844-00065461": "To get to those back to those items scroll back up to the top and you'll see something here that says folder has items", "iGBeJKNyIII-00134-00065519-00065752": "From here. You can go to a folder view", "iGBeJKNyIII-00135-00065752-00066109": "This shows me everything that I have in my folder so far from here", "iGBeJKNyIII-00136-00066110-00066719": "You can print out these you can email them you can save them or you can export them if you're using some sort of reference", "iGBeJKNyIII-00137-00066747-00067076": "Manager just make sure you do something with these", "iGBeJKNyIII-00138-00067119-00067684": "Before you close your browser and stop searching even if you close your browser for just a second and come back in", "iGBeJKNyIII-00139-00067710-00067931": "Everything will be gone. This is heartbreaking", "iGBeJKNyIII-00140-00067958-00068161": "Another way to save these items besides", "iGBeJKNyIII-00141-00068187-00068657": "Emailing them printing them or saving them is to create an EBSCO account to do this", "iGBeJKNyIII-00142-00068664-00069226": "You can click on sign in here or you can sign in here and from here. You can create a new account", "iGBeJKNyIII-00143-00069243-00069853": "This account will work as long as you're an ISU student and it will keep everything as long as you're an ISU student", "iGBeJKNyIII-00144-00069854-00070088": "This is a very good way to keep track of what you're searching for", "iGBeJKNyIII-00145-00070137-00070879": "We've just covered a few different methods to search the CINAHL database and also how to organize your searches in the CINAHL database", "iGBeJKNyIII-00146-00070919-00071314": "Please contact me if you have any questions about using CINAHL.", "iGBeJKNyIII-00147-00071314-00071911": "I know it's not super easy to use when you first get started, and it can be a challenge. I'm happy to help."}}, {"audio_id": "iGHIT2T6qAc", "text": {"iGHIT2T6qAc-00000-00000000-00000168": "asalam alykum wr wb", "iGHIT2T6qAc-00001-00000168-00000536": "hello guys welcome to the channel hope you're having yourself a wonderful day in today's", "iGHIT2T6qAc-00002-00000536-00001064": "video we'll be reacting to child police of indonesia this video was suggested by", "iGHIT2T6qAc-00003-00001064-00001504": "eli uni thank you very much for taking the time to send me your recommendation", "iGHIT2T6qAc-00004-00001504-00001928": "and suggestion uh for those of you who are new and who happen to come across this channel and", "iGHIT2T6qAc-00005-00001928-00002304": "this video for the first time i'd like to take a moment and welcome you guys to the channel", "iGHIT2T6qAc-00006-00002304-00002728": "i upload videos every day so if you guys like the content as well as the channel and want to be part", "iGHIT2T6qAc-00007-00002728-00003104": "of this journey then please consider subscribing to the channel and turning notification on", "iGHIT2T6qAc-00008-00003104-00003424": "so you're notified when a new video is uploaded stay tuned guys we'll be right back", "iGHIT2T6qAc-00009-00004128-00004472": "welcome back guys we're gonna get started with the video momentarily and at the end of the video i'll", "iGHIT2T6qAc-00010-00004472-00004904": "be sharing with you my observation and reaction so please make sure you stay until the end", "iGHIT2T6qAc-00011-00004904-00005784": "and with that said let's get started with the second video of the day", "iGHIT2T6qAc-00012-00006504-00007184": "okay", "iGHIT2T6qAc-00013-00007423-00008584": "wow", "iGHIT2T6qAc-00014-00012704-00012784": "it's so cool", "iGHIT2T6qAc-00015-00013119-00013263": "that's hot they're so disciplined", "iGHIT2T6qAc-00016-00013647-00014008": "and it looks like it goes on height the tallest one is at the front", "iGHIT2T6qAc-00017-00014008-00014184": "and the shortest ones are at the back", "iGHIT2T6qAc-00018-00015576-00017312": "oh wow that was nice lining up making sure they have a proper", "iGHIT2T6qAc-00019-00017312-00018384": "distance", "iGHIT2T6qAc-00020-00019288-00021480": "guys respect to these little guys you know nice please get my shoulders good", "iGHIT2T6qAc-00021-00021952-00022584": "who's he gonna go see", "iGHIT2T6qAc-00022-00023008-00023984": "nice the crowd is loving it", "iGHIT2T6qAc-00023-00025280-00025384": "foreign", "iGHIT2T6qAc-00024-00026000-00027127": "oh i like this one more than the adult ones nice", "iGHIT2T6qAc-00025-00030808-00030983": "oh", "iGHIT2T6qAc-00026-00032144-00032383": "oh nice", "iGHIT2T6qAc-00027-00033552-00033784": "nice", "iGHIT2T6qAc-00028-00035712-00035920": "no way that's so cool", "iGHIT2T6qAc-00029-00036272-00036584": "wow no way", "iGHIT2T6qAc-00030-00036800-00037224": "that's so cool they divide into two teams", "iGHIT2T6qAc-00031-00037352-00037984": "wow", "iGHIT2T6qAc-00032-00038088-00039712": "nice so they all lined up the same time", "iGHIT2T6qAc-00033-00039976-00040784": "oh i remember seeing this in japan where they were doing the drill and they were going super fast oh", "iGHIT2T6qAc-00034-00041416-00041466": "wow", "iGHIT2T6qAc-00035-00042016-00043584": "wow these guys are on another level", "iGHIT2T6qAc-00036-00048776-00049184": "food", "iGHIT2T6qAc-00037-00050440-00050584": "no", "iGHIT2T6qAc-00038-00053272-00053384": "is", "iGHIT2T6qAc-00039-00054000-00054784": "and stuff", "iGHIT2T6qAc-00040-00057320-00057584": "nice", "iGHIT2T6qAc-00041-00058176-00058984": "nice", "iGHIT2T6qAc-00042-00059591-00060384": "i think he's probably gonna lead them back because he's gone", "iGHIT2T6qAc-00043-00060655-00061784": "maybe he's going to ask for permission", "iGHIT2T6qAc-00044-00062008-00062591": "the crowd is love and i think even the crowd is loving it more than the uh the animals", "iGHIT2T6qAc-00045-00062879-00064584": "you know showing them more love and cheering for them clapping", "iGHIT2T6qAc-00046-00064712-00065984": "i really like that turn super cool in all of them same time", "iGHIT2T6qAc-00047-00067352-00067960": "well mashallah guys my daughter's trying to get into the room but i have to make my video if not", "iGHIT2T6qAc-00048-00067960-00068480": "she's going to be touching the camera and the laptop but with the video i enjoyed it quite", "iGHIT2T6qAc-00049-00068480-00069088": "a bit the little ones are just on another level and really disciplined uh on point", "iGHIT2T6qAc-00050-00069088-00069520": "and you know i was looking to see for example if they're gonna make any mistake one person", "iGHIT2T6qAc-00051-00069520-00070056": "maybe turn a little bit faster or whatnot but all of them were on point just like you know", "iGHIT2T6qAc-00052-00070128-00070744": "instantly they're moving the same way hands feet falling to the ground standing which i liked it", "iGHIT2T6qAc-00053-00070744-00071224": "quite a bit because for kids it's hard to get their attention and try to keep them still and", "iGHIT2T6qAc-00054-00071224-00071744": "it was not a short one too it was at least maybe like seven to eight minutes long and", "iGHIT2T6qAc-00055-00071744-00072184": "they had so many routines so small they have to memorize that all right because okay after", "iGHIT2T6qAc-00056-00072184-00072672": "this i gotta do that i gotta do that i gotta do that and like that's a long routine uh and it's", "iGHIT2T6qAc-00057-00072672-00073136": "not easy but you know all those spontaneous bless them they're really really talented kids i really", "iGHIT2T6qAc-00058-00073136-00073520": "really enjoyed it thank you very much guys for suggesting it if you if you have another", "iGHIT2T6qAc-00059-00073520-00073976": "video like this please put in the comment section below as always guys if you like this video please", "iGHIT2T6qAc-00060-00073976-00074432": "don't forget to like comment share and subscribe um i hope you guys have yourself a wonderful day", "iGHIT2T6qAc-00061-00074432-00075784": "guys take care yourself and your family inshaallah i'll see you guys in the next video take care and wassalam"}}, {"audio_id": "iH49Cls5IkA", "text": {"iH49Cls5IkA-00000-00000050-00001056": "[ Music ]", "iH49Cls5IkA-00001-00001106-00001280": ">> Hi. I'm Dr. Jim Dole.", "iH49Cls5IkA-00002-00001321-00001565": "I'm a Professor Emeritus at this university.", "iH49Cls5IkA-00003-00001565-00001780": "In other words I've been around here for a long time.", "iH49Cls5IkA-00004-00001780-00002071": "Professor Emeritus, by the way, if it doesn't mean anything", "iH49Cls5IkA-00005-00002071-00002345": "to you, simply means I'm a retired professor.", "iH49Cls5IkA-00006-00002396-00002572": "But having been here for a half of century,", "iH49Cls5IkA-00007-00002572-00002703": "and that's literally true.", "iH49Cls5IkA-00008-00002703-00002851": "I've been here for 50 years.", "iH49Cls5IkA-00009-00002904-00003068": "I know the system fairly well.", "iH49Cls5IkA-00010-00003118-00003433": "I understand pretty well what's mistake students make.", "iH49Cls5IkA-00011-00003480-00003855": "And my job this morning is to talk to you about the mistakes", "iH49Cls5IkA-00012-00003882-00004041": "that you don't want to make.", "iH49Cls5IkA-00013-00004097-00004262": "And in particular, what I want to talk to you", "iH49Cls5IkA-00014-00004262-00004530": "about is your Grade Point Average or your GPA.", "iH49Cls5IkA-00015-00004530-00004992": "This is extremely important because, your GPA,", "iH49Cls5IkA-00016-00004992-00005241": "whatever you graduate with will follow you", "iH49Cls5IkA-00017-00005241-00005371": "for the rest of your life.", "iH49Cls5IkA-00018-00005444-00005843": "If for example, you apply for a job.", "iH49Cls5IkA-00019-00005924-00006137": "Your GPA will probably be one", "iH49Cls5IkA-00020-00006137-00006337": "of the first things your perspective employer will", "iH49Cls5IkA-00021-00006337-00006394": "asked about.", "iH49Cls5IkA-00022-00006469-00006679": "If you're applying for a graduate program,", "iH49Cls5IkA-00023-00006723-00006896": "certainly your GPA will make a difference", "iH49Cls5IkA-00024-00006896-00007036": "in whether you get accepted or not.", "iH49Cls5IkA-00025-00007113-00007354": "On the other hand, if you're thinking about going at one", "iH49Cls5IkA-00026-00007354-00007601": "of the medical professions, one of the healthcare professions,", "iH49Cls5IkA-00027-00007601-00007893": "medicine, dentistry, pharmacy, anything of that sort,", "iH49Cls5IkA-00028-00007928-00008172": "your GPA can make all the difference in the world.", "iH49Cls5IkA-00029-00008202-00008463": "If you have a high enough GPA, you'll be considered.", "iH49Cls5IkA-00030-00008511-00008707": "If you don't, they'll simply not even look", "iH49Cls5IkA-00031-00008707-00008832": "at the rest of your application.", "iH49Cls5IkA-00032-00008841-00009112": "So, it's really important that you have a high GPA.", "iH49Cls5IkA-00033-00009194-00009441": "And what I want to do is talk about that GPA", "iH49Cls5IkA-00034-00009441-00009679": "and several different aspects of it.", "iH49Cls5IkA-00035-00009724-00010224": "For example, such things as how your GPA is calculated.", "iH49Cls5IkA-00036-00010321-00010518": "It's a very straightforward sort of thing,", "iH49Cls5IkA-00037-00010518-00010678": "but it is something you need to understand.", "iH49Cls5IkA-00038-00010711-00011011": "I'm also going to talk about your three GPAs.", "iH49Cls5IkA-00039-00011011-00011053": "That's right.", "iH49Cls5IkA-00040-00011088-00011165": "You got three.", "iH49Cls5IkA-00041-00011174-00011610": "I'm going to talk about why improving your GPA gets more", "iH49Cls5IkA-00042-00011610-00011950": "and more difficult as you progress towards your degree.", "iH49Cls5IkA-00043-00012020-00012283": "This is just a mathematical fact but you need to know that.", "iH49Cls5IkA-00044-00012344-00012500": "I also want to talk about the fact", "iH49Cls5IkA-00045-00012546-00012910": "that repeating a course can affect your GPA not necessarily", "iH49Cls5IkA-00046-00012910-00012968": "for the good.", "iH49Cls5IkA-00047-00012968-00013113": "It depends on how you work at it.", "iH49Cls5IkA-00048-00013113-00013231": "I'll explain that in a minute.", "iH49Cls5IkA-00049-00013321-00013571": "And I'm also going to point out how failure", "iH49Cls5IkA-00050-00013571-00013821": "to follow certain rules in particular the rules", "iH49Cls5IkA-00051-00013821-00014250": "for withdrawing from a class can make a difference in your GPA.", "iH49Cls5IkA-00052-00014310-00014653": "Sometimes profound, but not welcome difference.", "iH49Cls5IkA-00053-00014717-00014823": "Let me start by talking", "iH49Cls5IkA-00054-00014823-00015032": "about how would you calculate your GPA.", "iH49Cls5IkA-00055-00015047-00015197": "I've given you the formula for it.", "iH49Cls5IkA-00056-00015242-00015449": "You'll notice it's simply the number of units", "iH49Cls5IkA-00057-00015458-00015683": "for a particular course times the grade points", "iH49Cls5IkA-00058-00015683-00015850": "that you've earned for the letter grade", "iH49Cls5IkA-00059-00015850-00015963": "that you earned to that course.", "iH49Cls5IkA-00060-00016021-00016307": "You sum all of those for all of your classes and divide it", "iH49Cls5IkA-00061-00016307-00016481": "by the sum of the all of all of the units.", "iH49Cls5IkA-00062-00016572-00016807": "But you first have to know that here at Northridge,", "iH49Cls5IkA-00063-00016869-00017461": "there is ability to have an A minus or B minutes or C plus", "iH49Cls5IkA-00064-00017461-00017740": "or any those things or plus or minus after the letter grade", "iH49Cls5IkA-00065-00017776-00018000": "and they come up with different values.", "iH49Cls5IkA-00066-00018000-00018401": "For example, if you get a minus after the letter grade,", "iH49Cls5IkA-00067-00018436-00018761": "the point value will be three-tenths of a point less", "iH49Cls5IkA-00068-00018771-00018890": "than the letter grade itself.", "iH49Cls5IkA-00069-00018890-00019243": "If you have a plus after it, it's three-tenths of point more", "iH49Cls5IkA-00070-00019243-00019406": "than the letter grade itself.", "iH49Cls5IkA-00071-00019410-00019777": "So you can see on this chart the standard values for each", "iH49Cls5IkA-00072-00019777-00019869": "of those letter grades.", "iH49Cls5IkA-00073-00019946-00020072": "Let me just give you an example", "iH49Cls5IkA-00074-00020072-00020314": "of one particular hypothetical student", "iH49Cls5IkA-00075-00020314-00020459": "so we can calculate the GPA.", "iH49Cls5IkA-00076-00020459-00020680": "You'll notice, for example,", "iH49Cls5IkA-00077-00020680-00020911": "this particular student took Biology 106", "iH49Cls5IkA-00078-00020911-00021255": "and earned an A. The A is worth 4 points.", "iH49Cls5IkA-00079-00021300-00021491": "The course itself is worth 3 units.", "iH49Cls5IkA-00080-00021531-00021685": "So 3 times 4 gives you 12.", "iH49Cls5IkA-00081-00021685-00021852": "We put that in the far right column.", "iH49Cls5IkA-00082-00021953-00022259": "This person also took Biology 106 lab", "iH49Cls5IkA-00083-00022259-00022445": "which is a one unit course but in", "iH49Cls5IkA-00084-00022445-00022655": "that course she earned an A minus.", "iH49Cls5IkA-00085-00022655-00022913": "An A minus is worth 3.7, so we multiply", "iH49Cls5IkA-00086-00022913-00023347": "that 3.7 times the 1 unit we get 3.7 in the far right column.", "iH49Cls5IkA-00087-00023467-00023842": "This person also completed Chemistry 100 earned a C,", "iH49Cls5IkA-00088-00023868-00024136": "and C is worth 2 points [inaudible] the course itself is", "iH49Cls5IkA-00089-00024136-00024354": "worth 3 units, so 3 times 2 gives you 6", "iH49Cls5IkA-00090-00024354-00024678": "in the far right column then you simply sum the far right column", "iH49Cls5IkA-00091-00024678-00025140": "for 21.7 and divide that by the 7 units.", "iH49Cls5IkA-00092-00025163-00025526": "And this person then has a value of-- GPA value of 3.1.", "iH49Cls5IkA-00093-00025703-00025988": "Now, that's fairly straightforward and fairly easy", "iH49Cls5IkA-00094-00025988-00026421": "to do and there are actually some spreadsheets available", "iH49Cls5IkA-00095-00026421-00026591": "online where you can create your own.", "iH49Cls5IkA-00096-00026591-00026681": "It allows you do it.", "iH49Cls5IkA-00097-00026681-00026789": "It doesn't take a lot of work.", "iH49Cls5IkA-00098-00026805-00026998": "But what I want you to know also is", "iH49Cls5IkA-00099-00026998-00027244": "that you have three GPAs as I said.", "iH49Cls5IkA-00100-00027317-00027465": "And each one is important.", "iH49Cls5IkA-00101-00027529-00027820": "The first GPA is one we called the overall GPA.", "iH49Cls5IkA-00102-00027820-00028287": "And this grade point average is based entirely upon all", "iH49Cls5IkA-00103-00028287-00028521": "of the courses you've taken whether they were taken here", "iH49Cls5IkA-00104-00028521-00028742": "or at any other institution of higher learning.", "iH49Cls5IkA-00105-00028742-00029029": "In other words, if you took courses at Community College", "iH49Cls5IkA-00106-00029084-00029382": "and you put them on your record here, they will be included", "iH49Cls5IkA-00107-00029382-00029666": "in this GPA as well as all the courses that you've take", "iH49Cls5IkA-00108-00029666-00029779": "at Cal State Northridge.", "iH49Cls5IkA-00109-00029860-00030173": "The second GPA includes just those courses taken here", "iH49Cls5IkA-00110-00030173-00030235": "at Northridge.", "iH49Cls5IkA-00111-00030276-00030521": "No others, but all the courses taken here", "iH49Cls5IkA-00112-00030560-00030805": "for which you've earned the letter grade will be included", "iH49Cls5IkA-00113-00030805-00030903": "in your GPA here.", "iH49Cls5IkA-00114-00030944-00031078": "The third GPA is the one", "iH49Cls5IkA-00115-00031078-00031236": "that most people don't know anything about,", "iH49Cls5IkA-00116-00031241-00031491": "but it is critical and can make a big difference.", "iH49Cls5IkA-00117-00031491-00031855": "And that is what we call the upper-division major GPA.", "iH49Cls5IkA-00118-00031855-00032351": "And all that means is that you have a third GPA based entirely", "iH49Cls5IkA-00119-00032351-00032649": "upon the courses that you have taken", "iH49Cls5IkA-00120-00032649-00033150": "at the upper-division level meaning 300 or above and are", "iH49Cls5IkA-00121-00033150-00033300": "in the major, the biology major.", "iH49Cls5IkA-00122-00033367-00033544": "So, you got three GPAs.", "iH49Cls5IkA-00123-00033544-00033938": "But what you also need to know is that in order to graduate,", "iH49Cls5IkA-00124-00033938-00034418": "you have to have a 2.0 GPA in all three of them, not just one,", "iH49Cls5IkA-00125-00034482-00034849": "every single one of those GPAs requires a 2.0 or better,", "iH49Cls5IkA-00126-00034875-00035123": "hopefully a whole lot better in order to graduate.", "iH49Cls5IkA-00127-00035235-00035396": "OK. What I'd like to do at this point is", "iH49Cls5IkA-00128-00035396-00035856": "to demonstrate what happens to a GPA, a person's GPA, when he", "iH49Cls5IkA-00129-00035856-00036343": "or she takes four-unit class and earns an A in that class.", "iH49Cls5IkA-00130-00036448-00036681": "And I'm going to deal with the person starting", "iH49Cls5IkA-00131-00036699-00036789": "when he's a freshman.", "iH49Cls5IkA-00132-00036821-00037084": "At this point, let's say he has 10 units earned.", "iH49Cls5IkA-00133-00037175-00037564": "Since he has a 3.0 that means he's earned 30 points", "iH49Cls5IkA-00134-00037564-00037826": "as 10 units which is where he gets 3.0.", "iH49Cls5IkA-00135-00037826-00038077": "But let's say he earned 4 units of A.", "iH49Cls5IkA-00136-00038077-00038349": "And what does that do to his GPA?", "iH49Cls5IkA-00137-00038385-00038685": "It changes it from a 3.0 to a 3.28.", "iH49Cls5IkA-00138-00038726-00038905": "That's a significant change.", "iH49Cls5IkA-00139-00038905-00039194": "That's a very big change and very welcome change.", "iH49Cls5IkA-00140-00039247-00039411": "But what I want you to see is what happens", "iH49Cls5IkA-00141-00039411-00039658": "to that same individual when he's a junior.", "iH49Cls5IkA-00142-00039708-00039962": "What effect does that same four-unit course have?", "iH49Cls5IkA-00143-00040023-00040327": "Let's assume now that he's starting his junior year", "iH49Cls5IkA-00144-00040327-00040855": "with 60 units, with a 3.0 that means he has 180 points,", "iH49Cls5IkA-00145-00040878-00041120": "60 units earned, gives him a 3.0.", "iH49Cls5IkA-00146-00041168-00041507": "Now, let's assume this person takes a four-unit class", "iH49Cls5IkA-00147-00041507-00041717": "and earns an A. What does that do to his GPA?", "iH49Cls5IkA-00148-00041717-00042012": "And the answer is, it raises it from a 3.0", "iH49Cls5IkA-00149-00042012-00042325": "through a 3.06, not a very big jump.", "iH49Cls5IkA-00150-00042424-00042742": "In other words, even though he took one four-unit class", "iH49Cls5IkA-00151-00042742-00042952": "in each case earned an A in both of them.", "iH49Cls5IkA-00152-00042998-00043136": "In one case when he was a freshman,", "iH49Cls5IkA-00153-00043136-00043317": "it made a big difference; as a junior,", "iH49Cls5IkA-00154-00043317-00043557": "it made a piddling little difference,", "iH49Cls5IkA-00155-00043557-00043668": "not much of a difference at all.", "iH49Cls5IkA-00156-00043668-00043989": "And the reason for that is simple mathematics.", "iH49Cls5IkA-00157-00044031-00044294": "It's simply that when you are a freshman", "iH49Cls5IkA-00158-00044325-00044479": "and you have let's say four units", "iH49Cls5IkA-00159-00044479-00044660": "to all the units you already completed,", "iH49Cls5IkA-00160-00044681-00045049": "that four units is a big portion of the units you have.", "iH49Cls5IkA-00161-00045086-00045372": "If you've add 4 units to the 10 that you already have,", "iH49Cls5IkA-00162-00045372-00045941": "that 4 of the 14 is going to be a large number, large proportion", "iH49Cls5IkA-00163-00045955-00046259": "and it will affect your GPA calculations accordingly.", "iH49Cls5IkA-00164-00046299-00046673": "On the other hand, when you're a junior and you add 4 units", "iH49Cls5IkA-00165-00046694-00047036": "to the 60 units you already have, now you have 64 units,", "iH49Cls5IkA-00166-00047036-00047406": "the 4 is a very small-- much smaller portion of the 64.", "iH49Cls5IkA-00167-00047464-00047799": "As a consequence it has a much smaller effect on your GPA.", "iH49Cls5IkA-00168-00047799-00048146": "Let me show you a table that will illustrate this.", "iH49Cls5IkA-00169-00048194-00048592": "Again, I've taken-- created this table assuming the student has a", "iH49Cls5IkA-00170-00048592-00049024": "3.0, and I've taking it from a freshmen year", "iH49Cls5IkA-00171-00049024-00049268": "when he has let's say 10 units all the way up to", "iH49Cls5IkA-00172-00049278-00049584": "when that person is near graduation with 120 units.", "iH49Cls5IkA-00173-00049594-00049831": "And you'll notice, for example, as we've seen", "iH49Cls5IkA-00174-00049831-00050169": "that as a freshmen, that four-unit class with As got him", "iH49Cls5IkA-00175-00050169-00050655": "from a 3.0 to 3.28; as a junior, from a 3.0 to a 3.06;", "iH49Cls5IkA-00176-00050696-00051022": "as a graduating senior, that same 4 units would move him", "iH49Cls5IkA-00177-00051022-00051551": "from a 3.0 to a 3.03, a very tiny fraction of a change.", "iH49Cls5IkA-00178-00051624-00051931": "Now, just to show you how this works.", "iH49Cls5IkA-00179-00051931-00052165": "Again, I'm going to choose to illustrate it", "iH49Cls5IkA-00180-00052165-00052431": "with 12 units of courses worth As.", "iH49Cls5IkA-00181-00052431-00052649": "And you can see that it makes a big difference", "iH49Cls5IkA-00182-00052649-00053052": "for the freshmen coming from a 3.0 to a 3.54,", "iH49Cls5IkA-00183-00053110-00053243": "but a very small difference", "iH49Cls5IkA-00184-00053248-00053598": "for graduating senior from a 3.0 to 3.09.", "iH49Cls5IkA-00185-00053693-00053886": "In other words, the longer you're here", "iH49Cls5IkA-00186-00053886-00054049": "and the more units you accumulate,", "iH49Cls5IkA-00187-00054049-00054218": "the harder it is to change your GPA.", "iH49Cls5IkA-00188-00054218-00054753": "And I mentioned this because I've actually had students come", "iH49Cls5IkA-00189-00054753-00055170": "to me and tell me that they are a changed person.", "iH49Cls5IkA-00190-00055187-00055432": "For example, it's the story usually goes something", "iH49Cls5IkA-00191-00055432-00055481": "like this.", "iH49Cls5IkA-00192-00055557-00055837": "I've-- I'm starting my junior year.", "iH49Cls5IkA-00193-00055866-00055981": "I've not done very well.", "iH49Cls5IkA-00194-00055981-00056148": "I've maybe made a C average.", "iH49Cls5IkA-00195-00056197-00056383": "But I really want to make it to medical school.", "iH49Cls5IkA-00196-00056383-00056743": "I'm going to work really hard in the next two years.", "iH49Cls5IkA-00197-00056743-00056896": "I'm going to earn all As and I'm going", "iH49Cls5IkA-00198-00056896-00057003": "to make it to medical school.", "iH49Cls5IkA-00199-00057003-00057234": "I'm gong to get my GPA up high enough that I can do that.", "iH49Cls5IkA-00200-00057333-00057660": "Well, the point of this is that that's not really possible.", "iH49Cls5IkA-00201-00057660-00057821": "Let me explain.", "iH49Cls5IkA-00202-00057926-00058299": "First of all, you probably understand that the probability", "iH49Cls5IkA-00203-00058312-00058682": "of a student who is a straight C student or a C average student", "iH49Cls5IkA-00204-00058682-00058889": "for two years is not suddenly likely", "iH49Cls5IkA-00205-00058889-00059022": "to become a straight A student.", "iH49Cls5IkA-00206-00059067-00059386": "But even if we assumed that he did become a straight A student,", "iH49Cls5IkA-00207-00059430-00060164": "his GPA would go from a 2.0 to a 3.0 which is a nice increase.", "iH49Cls5IkA-00208-00060181-00060315": "That's certainly worthy.", "iH49Cls5IkA-00209-00060377-00060661": "But it's not enough to get into the medical school.", "iH49Cls5IkA-00210-00060692-00060892": "Now, you need to also know something", "iH49Cls5IkA-00211-00060892-00061249": "about repeating classes because this too kind", "iH49Cls5IkA-00212-00061249-00061463": "of influence your great point average", "iH49Cls5IkA-00213-00061463-00061778": "if you do some things incorrectly.", "iH49Cls5IkA-00214-00061837-00062305": "University rules permits you to repeat up to 16 units", "iH49Cls5IkA-00215-00062305-00062606": "of class work for what is commonly called", "iH49Cls5IkA-00216-00062606-00062755": "grade forgiveness.", "iH49Cls5IkA-00217-00062816-00062961": "But don't misunderstand this.", "iH49Cls5IkA-00218-00062970-00063414": "This does not mean that your earlier grade is somehow painted", "iH49Cls5IkA-00219-00063414-00063652": "out and a new grade is placed on in place", "iH49Cls5IkA-00220-00063652-00063755": "of it, that doesn't happen.", "iH49Cls5IkA-00221-00063849-00064192": "What happens is that both grades remain on your record,", "iH49Cls5IkA-00222-00064248-00064612": "but the newest grade presumably the higher grade is the one used", "iH49Cls5IkA-00223-00064612-00064784": "in calculating your GPA.", "iH49Cls5IkA-00224-00064881-00064983": "That's important to know.", "iH49Cls5IkA-00225-00065057-00065304": "Now, you can do that for 16 units, but you have", "iH49Cls5IkA-00226-00065304-00065708": "to understand also that you only get a grade forgiveness", "iH49Cls5IkA-00227-00065708-00066283": "if you repeat the same course at the same institution and only", "iH49Cls5IkA-00228-00066283-00066489": "for the first 16 units.", "iH49Cls5IkA-00229-00066576-00066837": "Now, you can repeat courses beyond the 16 units.", "iH49Cls5IkA-00230-00066889-00067375": "But if you do, and you can only go 28, then that from--", "iH49Cls5IkA-00231-00067379-00067589": "after the 16 units, what happens is that both", "iH49Cls5IkA-00232-00067589-00067991": "of the grades are included in your calculations or your GPA.", "iH49Cls5IkA-00233-00067991-00068461": "For example, if you repeated a class in which you earned an F", "iH49Cls5IkA-00234-00068487-00068815": "and got a C, both of those grades will be included", "iH49Cls5IkA-00235-00068815-00069026": "in calculating your GPA and that's the equivalent", "iH49Cls5IkA-00236-00069026-00069393": "of earning a D. Or if you had an F the first time", "iH49Cls5IkA-00237-00069393-00069562": "and then you repeated it and got an A,", "iH49Cls5IkA-00238-00069617-00069863": "both of those grades would be included in your calculation", "iH49Cls5IkA-00239-00069863-00070221": "of a GPA and that's the equivalent of earning a C. OK.", "iH49Cls5IkA-00240-00070221-00070469": "The point is, you have to be really careful about this.", "iH49Cls5IkA-00241-00070557-00070774": "The other point that you need to understand is this,", "iH49Cls5IkA-00242-00070847-00071195": "that if you repeat a class or try to repeat a class,", "iH49Cls5IkA-00243-00071251-00071551": "you may find yourself in a situation", "iH49Cls5IkA-00244-00071551-00071779": "where you just simply can't get in to the class.", "iH49Cls5IkA-00245-00071779-00072019": "For example, if you're repeating a class,", "iH49Cls5IkA-00246-00072019-00072417": "the university rules require that you not enroll in a class", "iH49Cls5IkA-00247-00072417-00072734": "until four days before the class begins.", "iH49Cls5IkA-00248-00072789-00072962": "And if you know anything at all about what happens", "iH49Cls5IkA-00249-00072962-00073138": "at this university, most of the classes are going", "iH49Cls5IkA-00250-00073138-00073239": "to be full at that point.", "iH49Cls5IkA-00251-00073282-00073480": "So the chances of getting into a class", "iH49Cls5IkA-00252-00073520-00073744": "that you're repeating are very tiny.", "iH49Cls5IkA-00253-00073799-00074127": "The best thing you might do is try to take the class", "iH49Cls5IkA-00254-00074127-00074319": "in the summer because then there's less competition.", "iH49Cls5IkA-00255-00074376-00074615": "But in any case, it's tough to get into a class", "iH49Cls5IkA-00256-00074615-00074732": "when you're repeating it.", "iH49Cls5IkA-00257-00074826-00075037": "So, what's the moral of all this that I'm saying?", "iH49Cls5IkA-00258-00075085-00075247": "It basically boils down to this.", "iH49Cls5IkA-00259-00075247-00075655": "And that is, when you enroll in a class, take it seriously.", "iH49Cls5IkA-00260-00075730-00076040": "Don't assume as some do that, \"Oh, I can goof around here", "iH49Cls5IkA-00261-00076040-00076189": "and if I have to, I'll repeat it.\"", "iH49Cls5IkA-00262-00076189-00076461": "No, you don't want to ever repeat a class", "iH49Cls5IkA-00263-00076482-00076564": "if you can avoid it.", "iH49Cls5IkA-00264-00076573-00076800": "If you have no choice, of course you repeat it.", "iH49Cls5IkA-00265-00076869-00077105": "But try never to get in that situation.", "iH49Cls5IkA-00266-00077183-00077413": "Earn the best grades you can the first time through.", "iH49Cls5IkA-00267-00077542-00077930": "If your aim is to graduate with a high GPA,", "iH49Cls5IkA-00268-00077930-00078454": "and I hope that's the case, then the way to do it is to start", "iH49Cls5IkA-00269-00078483-00078850": "with a high GPA, earn it now and keep it there.", "iH49Cls5IkA-00270-00078932-00079090": "You can't play catch up.", "iH49Cls5IkA-00271-00079090-00079195": "It just simply doesn't work.", "iH49Cls5IkA-00272-00079300-00079521": "One of the facts that you need to understand is", "iH49Cls5IkA-00273-00079521-00079766": "that withdrawing from a class, if it's done", "iH49Cls5IkA-00274-00079766-00080067": "and properly can greatly affect your GPA.", "iH49Cls5IkA-00275-00080097-00080293": "I've actually have students who've made some", "iH49Cls5IkA-00276-00080293-00080381": "serious mistakes.", "iH49Cls5IkA-00277-00080381-00080566": "And I want you not to make those mistakes.", "iH49Cls5IkA-00278-00080611-00080813": "But you'll notice that the withdrawal policy", "iH49Cls5IkA-00279-00080813-00081037": "at this university is such that if you withdraw", "iH49Cls5IkA-00280-00081037-00081465": "within the first three weeks of the semester, nothing happens.", "iH49Cls5IkA-00281-00081516-00081905": "It's also even possible to withdraw from a class later", "iH49Cls5IkA-00282-00081905-00082342": "in the semester provided you have a valid reason", "iH49Cls5IkA-00283-00082417-00082671": "and that you can convince the associate dean", "iH49Cls5IkA-00284-00082671-00082783": "that your reason is valid.", "iH49Cls5IkA-00285-00082835-00083155": "If you simply walkaway from a class that some students do,", "iH49Cls5IkA-00286-00083193-00083657": "and as a consequence, they wind up on their record with a grade", "iH49Cls5IkA-00287-00083657-00084025": "of WU which means an unofficial withdrawal.", "iH49Cls5IkA-00288-00084132-00084534": "A WU counts as though it were an F. In other words,", "iH49Cls5IkA-00289-00084534-00084998": "if you have a WU on there, it gives you no point value,", "iH49Cls5IkA-00290-00085051-00085401": "but counts as whatever number of units you should have earned", "iH49Cls5IkA-00291-00085440-00085708": "and that will affect your GPA negatively.", "iH49Cls5IkA-00292-00085766-00086267": "I even had a student who walked away not from just one class,", "iH49Cls5IkA-00293-00086267-00086461": "but from a whole semester of classes.", "iH49Cls5IkA-00294-00086461-00086759": "He came to me just a few months ago and was asking me,", "iH49Cls5IkA-00295-00086759-00086874": "what I do at this point?", "iH49Cls5IkA-00296-00086923-00087396": "I looked at his record, saw 16 units of WU or from the point", "iH49Cls5IkA-00297-00087396-00087822": "of view, the GPA 16 units of F. And he wanted", "iH49Cls5IkA-00298-00087822-00087978": "to know what does he do?", "iH49Cls5IkA-00299-00088063-00088360": "And the only thing I could tell him is you dug yourself", "iH49Cls5IkA-00300-00088360-00088488": "in a one heck of a big hole.", "iH49Cls5IkA-00301-00088488-00088911": "And the only way out is to work really hard in the future,", "iH49Cls5IkA-00302-00088968-00089219": "earn high grades and all the rest of the classes", "iH49Cls5IkA-00303-00089245-00089697": "and gradually get your GPA up to an acceptable level.", "iH49Cls5IkA-00304-00089723-00090038": "He was down below 2.0 at that point getting it", "iH49Cls5IkA-00305-00090038-00090395": "up to a 2.0 will be a struggle, but it can be done.", "iH49Cls5IkA-00306-00090460-00090725": "But please, don't get yourself in that situation.", "iH49Cls5IkA-00307-00090725-00091074": "And I highly recommend that you always, if you have to withdraw", "iH49Cls5IkA-00308-00091074-00091409": "from a class, do it officially, don't walk away.", "iH49Cls5IkA-00309-00091409-00091857": "If you have any other questions, give me a call, I'm available", "iH49Cls5IkA-00310-00091857-00092048": "at the advisement center or better yet,", "iH49Cls5IkA-00311-00092067-00092190": "stop by and talk to me.", "iH49Cls5IkA-00312-00092251-00093023": "[ Music ]"}}, {"audio_id": "iHk2nlEUs5E", "text": {"iHk2nlEUs5E-00000-00000000-00000200": "Is Tech Making Robin Bird Better Or Worse?"}}, {"audio_id": "iHLBZQMiKg0", "text": {"iHLBZQMiKg0-00000-00000076-00008848": "Cartoon x Time To Talk - Omen (Ft.", "iHLBZQMiKg0-00001-00008848-00016882": "Asena)"}}, {"audio_id": "iIgTNJBICGI", "text": {"iIgTNJBICGI-00000-00000006-00000558": "So what's the resolution? Let's examine each of these arguments in turn. Firstly", "iIgTNJBICGI-00001-00000558-00000990": "we can discount c). While different observers may observe things like", "iIgTNJBICGI-00002-00000990-00001515": "different lengths or different times, none of this is contradictory. Thinking", "iIgTNJBICGI-00003-00001515-00001941": "back to the muon example, someone on the earth would say the muon traveled a long", "iIgTNJBICGI-00004-00001941-00002466": "distance but it decayed slowly, whereas the muon would say indicate very", "iIgTNJBICGI-00005-00002466-00002976": "quickly but only traveled a short distance. Both of these people however", "iIgTNJBICGI-00006-00002976-00003398": "agree on the physical event which is whether or not the muon reaches the", "iIgTNJBICGI-00007-00003398-00003815": "Earth's surface. Here we have a physical event and it wouldn't make sense if one", "iIgTNJBICGI-00008-00003815-00004242": "person thinks the rope always stays intact, while someone else thinks that", "iIgTNJBICGI-00009-00004242-00004803": "it'll break. So now let's look at answer a). So this says that some sort of", "iIgTNJBICGI-00010-00004803-00005421": "contraction like this occurs. However this doesn't make sense.", "iIgTNJBICGI-00011-00005421-00005996": "So in Carl's frame they start off a distance L apart, and then he sees them", "iIgTNJBICGI-00012-00005996-00006489": "always moving at the same velocity. If they're moving at the same velocity they", "iIgTNJBICGI-00013-00006489-00006900": "have to stay the same distance apart -  there's no way that one of them can", "iIgTNJBICGI-00014-00006900-00007472": "catch up to the other or leave the other behind, and so we can discount answer a)", "iIgTNJBICGI-00015-00007472-00008093": "leaving us with b). So think back to the first series of lectures on Galilean", "iIgTNJBICGI-00016-00008093-00008571": "relativity, and what kinds of frames of reference we could consider. We said that", "iIgTNJBICGI-00017-00008571-00009009": "if you are inside a train moving very smoothly with all the windows covered", "iIgTNJBICGI-00018-00009009-00009435": "you could not tell what velocity you were traveling at; if you were going", "iIgTNJBICGI-00019-00009435-00009963": "forwards or backwards or not moving at all. If however that train was to", "iIgTNJBICGI-00020-00009963-00010539": "accelerate then you would feel it; then you could say 'yes I am accelerating and", "iIgTNJBICGI-00021-00010539-00011247": "we are going forwards'. Acceleration is absolute, not relative. Inertial frames of", "iIgTNJBICGI-00022-00011247-00011775": "reference are only defined for objects moving at constant velocity. In this case,", "iIgTNJBICGI-00023-00011775-00012354": "as Bob's speed is constantly increasing, at each incidence of time he moves into", "iIgTNJBICGI-00024-00012354-00012809": "a new inertial reference frame, and so it doesn't make sense for Bob to say in my", "iIgTNJBICGI-00025-00012809-00013230": "reference frame because he has many different reference frames all at", "iIgTNJBICGI-00026-00013230-00013626": "different speeds that he's constantly moving between. So the only", "iIgTNJBICGI-00027-00013626-00014025": "reasonable frame of reference to use is Carlos frame who is standing on the", "iIgTNJBICGI-00028-00014025-00014604": "ground. So what will Bob see? The fact that the rope breaks, tells us that he", "iIgTNJBICGI-00029-00014604-00014987": "will see Alice getting further and further away from him, even though both", "iIgTNJBICGI-00030-00014987-00015488": "he and Alice are thrusting forwards at the same rate. The reason for this turns", "iIgTNJBICGI-00031-00015488-00015971": "out to be due to relativity of simultaneity. At each instance in time", "iIgTNJBICGI-00032-00015971-00016529": "Bob moves into a new reference frame and in this he becomes simultaneous with Alice", "iIgTNJBICGI-00033-00016529-00017143": "at an earlier point in time, when she was further behind him."}}, {"audio_id": "iIw5Z2JkRB0", "text": {"iIw5Z2JkRB0-00000-00000000-00000050": ".....", "iIw5Z2JkRB0-00002-00000100-00000150": "no", "iIw5Z2JkRB0-00003-00000150-00000200": "had up", "iIw5Z2JkRB0-00004-00000200-00000250": "hand up now", "iIw5Z2JkRB0-00005-00000250-00000450": "SONG play", "iIw5Z2JkRB0-00006-00000450-00000650": "hand up  now", "iIw5Z2JkRB0-00007-00000650-00001050": "had up new man", "iIw5Z2JkRB0-00008-00001050-00001250": "no do it say", "iIw5Z2JkRB0-00009-00001250-00001450": "will  okay", "iIw5Z2JkRB0-00010-00001450-00001650": "i say had up  new", "iIw5Z2JkRB0-00011-00001650-00001850": "no POLICE", "iIw5Z2JkRB0-00012-00001850-00002050": "no thunks"}}, {"audio_id": "iIRes58GbKg", "text": {"iIRes58GbKg-00000-00000570-00000663": "Take one. Mark.", "iIRes58GbKg-00001-00000677-00000810": "Action.", "iIRes58GbKg-00002-00001107-00001367": "Hey, guys, I'm Miranda Cosgrove and I played Carly Shae.", "iIRes58GbKg-00003-00001381-00001855": "Uh, hello. I am Jerry Trainor, and I play Spencer on iCarly.", "iIRes58GbKg-00004-00001868-00002202": "What's up, everybody? Nathan Chris here. Freddie on...", "iIRes58GbKg-00005-00002215-00002549": "well, I Carly, but also...", "iIRes58GbKg-00006-00002592-00002682": "this.", "iIRes58GbKg-00007-00002695-00002839": "Hi, my name is Laci Mosley", "iIRes58GbKg-00008-00002852-00003059": "and I play Harper, Carly's best friend.", "iIRes58GbKg-00009-00003073-00003413": "Hi, guys. I'm Jaidyn and I play Millicent on iCarly.", "iIRes58GbKg-00010-00003456-00003707": "This. This new thing. This new thing that's happening.", "iIRes58GbKg-00011-00003720-00004107": "Years later, I will continue to play Spencer, it turns out.", "iIRes58GbKg-00012-00004120-00004207": "So here we are.", "iIRes58GbKg-00013-00004220-00004357": "Time is a flat circle.", "iIRes58GbKg-00014-00004370-00004471": "[giggling]", "iIRes58GbKg-00015-00004507-00004728": "Welcome. I'm happy that you're here.", "iIRes58GbKg-00016-00005251-00005368": "Because of COVID and everything", "iIRes58GbKg-00017-00005382-00005538": "the first table read was over Zoom,", "iIRes58GbKg-00018-00005552-00005739": "but it was still really fun and it was awesome", "iIRes58GbKg-00019-00005752-00005929": "just getting to get the gang back together again", "iIRes58GbKg-00020-00005942-00006262": "and see everyone and step back into these characters.", "iIRes58GbKg-00021-00006276-00006466": "Are we all looking at the same thing?", "iIRes58GbKg-00022-00006486-00006679": "The big opal crap?", "iIRes58GbKg-00023-00006739-00007093": "[chuckles] It's art. Not everyone has to like it.", "iIRes58GbKg-00024-00007130-00007280": "Why don't you like it?", "iIRes58GbKg-00025-00007517-00007757": "I clicked right out of this email.", "iIRes58GbKg-00026-00007784-00007917": "Harper, I gotta know!", "iIRes58GbKg-00027-00007931-00008144": "Why don't you like this sculpture?! Please!", "iIRes58GbKg-00028-00008191-00008321": "Ah, one second!", "iIRes58GbKg-00029-00008361-00008555": "How does it feel to be back on set?", "iIRes58GbKg-00030-00008568-00008952": "Uh, it feels very strange, uh, because it was unexpected.", "iIRes58GbKg-00031-00008965-00009239": "Man, this whole thing has just been such a blast", "iIRes58GbKg-00032-00009252-00009582": "and so surreal to be doing something that feels", "iIRes58GbKg-00033-00009596-00009856": "very familiar in a lot of ways,", "iIRes58GbKg-00034-00009869-00010183": "but also very new and very different", "iIRes58GbKg-00035-00010196-00010483": "and I think, as far as the fans at home are concerned,", "iIRes58GbKg-00036-00010497-00010610": "very unexpected.", "iIRes58GbKg-00037-00010623-00010780": "Coming on iCarly got me super excited", "iIRes58GbKg-00038-00010794-00011080": "because it feels so nostalgic to be, like, to be on these sets", "iIRes58GbKg-00039-00011094-00011387": "that are, you know, designed so much like the original", "iIRes58GbKg-00040-00011401-00011514": "and seeing, like, these...", "iIRes58GbKg-00041-00011528-00011778": "Uh, like, the soda can guy is here.", "iIRes58GbKg-00042-00011791-00011955": "Like, stuff that I've seen as a child,", "iIRes58GbKg-00043-00011968-00012162": "like, in person is so cool.", "iIRes58GbKg-00044-00012175-00012469": "It's really fun, actually. Like, everybody is so nice", "iIRes58GbKg-00045-00012482-00012722": "and I've been on a lot of, like, different shows", "iIRes58GbKg-00046-00012736-00012886": "that have negative energy.", "iIRes58GbKg-00047-00012899-00013213": "And here it's just so positive and everyone's so nice.", "iIRes58GbKg-00048-00013226-00013369": "I don't want to give too much away,", "iIRes58GbKg-00049-00013383-00013770": "but, you know, I don't think a reboot or a revival", "iIRes58GbKg-00050-00013783-00014107": "has been done quite like this, where something that was so...", "iIRes58GbKg-00051-00014120-00014417": "sort of geared towards young people is,", "iIRes58GbKg-00052-00014431-00014617": "now, ten years later,", "iIRes58GbKg-00053-00014631-00014784": "we're aiming at those same people", "iIRes58GbKg-00054-00014797-00014904": "that grew up with the show", "iIRes58GbKg-00055-00014918-00015055": "and it's like,", "iIRes58GbKg-00056-00015068-00015375": "\"What have the characters' lives turned out to be?\"", "iIRes58GbKg-00057-00015415-00015562": "Maybe not what we expected?", "iIRes58GbKg-00058-00015575-00015849": "Um, which is how real life happens.", "iIRes58GbKg-00059-00015862-00015995": "On this new version of iCarly,", "iIRes58GbKg-00060-00016009-00016259": "it's definitely made with the people in mind", "iIRes58GbKg-00061-00016272-00016446": "who loved the show from before,", "iIRes58GbKg-00062-00016459-00016616": "so it's been really fun getting to make", "iIRes58GbKg-00063-00016629-00016806": "a more mature and elevated version", "iIRes58GbKg-00064-00016820-00017080": "of the old iCarly and just see what these characters", "iIRes58GbKg-00065-00017093-00017250": "are doing now that they're in their twenties.", "iIRes58GbKg-00066-00017263-00017484": "This version is super dope because now", "iIRes58GbKg-00067-00017497-00017660": "we're all millennials, you know what I mean?", "iIRes58GbKg-00068-00017674-00017901": "So we have jobs, we have grown up problems,", "iIRes58GbKg-00069-00017914-00018281": "and it's fun to see these fun characters, like, as adults.", "iIRes58GbKg-00070-00018294-00018671": "We're doing something that we hope will feel", "iIRes58GbKg-00071-00018685-00019058": "very comfortable and like putting on a fuzzy blanket,", "iIRes58GbKg-00072-00019082-00019399": "but in a way that shakes things up a little bit.", "iIRes58GbKg-00073-00019412-00019532": "I can't talk to him.", "iIRes58GbKg-00074-00019562-00019686": "I'm just... It's a disaster.", "iIRes58GbKg-00075-00019699-00019889": "I'm not dating. I'm not making videos.", "iIRes58GbKg-00076-00019903-00020090": "I'm just so embarrassed about my life.", "iIRes58GbKg-00077-00020103-00020230": "And you should be!", "iIRes58GbKg-00078-00020243-00020433": "Your legs look like Eugene Levy's upper ass.", "iIRes58GbKg-00079-00020447-00020557": "You said that was feminist.", "iIRes58GbKg-00080-00020570-00020790": "- I lied! - Who can I trust?", "iIRes58GbKg-00081-00020807-00020924": "Carly...", "iIRes58GbKg-00082-00020937-00021341": "Missing the cast is a nuanced position.", "iIRes58GbKg-00083-00021354-00021638": "Sometimes you just need space from your family.", "iIRes58GbKg-00084-00021651-00021941": "I'm kidding. I'm kidding. I missed everyone so much.", "iIRes58GbKg-00085-00021955-00022152": "Yeah, it's just been great getting to be", "iIRes58GbKg-00086-00022165-00022295": "with Nathan and Jerry.", "iIRes58GbKg-00087-00022308-00022572": "I mean, they're honestly two of my oldest friends.", "iIRes58GbKg-00088-00022585-00022872": "The best part of coming back is...", "iIRes58GbKg-00089-00022886-00023173": "is obviously seeing Miranda and Nathan.", "iIRes58GbKg-00090-00023186-00023419": "And I've kept in touch all these years.", "iIRes58GbKg-00091-00023433-00023550": "They're so grown up now.", "iIRes58GbKg-00092-00023563-00023807": "Nathan's wife is about to have a baby,", "iIRes58GbKg-00093-00023820-00024063": "so we're going to get to be around during all that,", "iIRes58GbKg-00094-00024077-00024190": "which is gonna be really fun.", "iIRes58GbKg-00095-00024204-00024357": "We get to see each other...", "iIRes58GbKg-00096-00024457-00024621": "We saw each other pretty regularly.", "iIRes58GbKg-00097-00024634-00024814": "Uh, pre-pandemic, of course.", "iIRes58GbKg-00098-00024828-00024994": "But there's been a long period", "iIRes58GbKg-00099-00025008-00025175": "of not getting to see each other, obviously,", "iIRes58GbKg-00100-00025188-00025381": "with everything that's gone on in the world.", "iIRes58GbKg-00101-00025395-00025642": "So getting to reunite in this way", "iIRes58GbKg-00102-00025655-00025805": "has been very unexpected.", "iIRes58GbKg-00103-00025819-00025982": "It's just been awesome hanging out with Jerry.", "iIRes58GbKg-00104-00025995-00026212": "He is very good listener, I'll give him that. [laughs]", "iIRes58GbKg-00105-00026226-00026359": "Everyone is so fun.", "iIRes58GbKg-00106-00026372-00026559": "Everyone is so nice, funny.", "iIRes58GbKg-00107-00026573-00026800": "Jerry is super annoying, by the way.", "iIRes58GbKg-00108-00026843-00026963": "I can't even stand him.", "iIRes58GbKg-00109-00026976-00027173": "But, you know, he's fun to work with.", "iIRes58GbKg-00110-00027187-00027387": "Everybody is super fun to work with.", "iIRes58GbKg-00111-00027417-00027657": "And, you know, it's all just a fun relationship.", "iIRes58GbKg-00112-00027670-00027824": "We were, I think, all nervous.", "iIRes58GbKg-00113-00027837-00028104": "Like, \"What is this going to be? Are we gonna still have it?\"", "iIRes58GbKg-00114-00028117-00028364": "As soon as the three of us got on stage together,", "iIRes58GbKg-00115-00028378-00028558": "it was like... We were the same.", "iIRes58GbKg-00116-00028571-00028758": "I'm just messing with them, making jokes.", "iIRes58GbKg-00117-00028772-00028935": "We're just ripping on each other.", "iIRes58GbKg-00118-00028948-00029082": "It's like nothing changed.", "iIRes58GbKg-00119-00029095-00029539": "It's... That has been a blast and a real treat.", "iIRes58GbKg-00120-00029552-00029739": "The interactions have been great.", "iIRes58GbKg-00121-00029752-00029949": "Uh, it just feels like coming home.", "iIRes58GbKg-00122-00029986-00030160": "It's so interesting joining this cast", "iIRes58GbKg-00123-00030173-00030336": "because I obviously watched iCarly", "iIRes58GbKg-00124-00030350-00030520": "as a child growing up and never thought", "iIRes58GbKg-00125-00030533-00030887": "that I would actually somehow end up on the show.", "iIRes58GbKg-00126-00030900-00031024": "The cast is super nice", "iIRes58GbKg-00127-00031037-00031184": "and it feels like I've known them forever,", "iIRes58GbKg-00128-00031197-00031314": "which is fun to me,", "iIRes58GbKg-00129-00031327-00031488": "because they've known each other for so long.", "iIRes58GbKg-00130-00031501-00031678": "I feel really included and everyone's super nice.", "iIRes58GbKg-00131-00031691-00032145": "It's been a very strange mix of emotions and feelings,", "iIRes58GbKg-00132-00032158-00032312": "but it's all good stuff.", "iIRes58GbKg-00133-00032325-00032458": "It's all very exciting.", "iIRes58GbKg-00134-00032499-00032689": "Uh, and I think people are going to be pretty psyched about this", "iIRes58GbKg-00135-00032702-00032852": "when they get to see a little more.", "iIRes58GbKg-00136-00032866-00033039": "There's something for everybody in this show.", "iIRes58GbKg-00137-00033052-00033209": "If you were an old Stan of the show,", "iIRes58GbKg-00138-00033223-00033416": "there's tiny little Easter eggs and jokes", "iIRes58GbKg-00139-00033429-00033553": "that you'll hear, that you'll love", "iIRes58GbKg-00140-00033566-00033730": "and you'll remember from the original.", "iIRes58GbKg-00141-00033743-00033983": "And if you're new, then you get to see these grown up adults,", "iIRes58GbKg-00142-00033997-00034190": "you know, act so silly and have a good time", "iIRes58GbKg-00143-00034204-00034380": "and it's a fun show to watch and chill.", "iIRes58GbKg-00144-00034394-00034631": "I can't wait for you guys to see me on the new iCarly.", "iIRes58GbKg-00145-00034644-00034881": "I've got to go finish filming so I'll see you guys later.", "iIRes58GbKg-00146-00034894-00035011": "Bye!"}}, {"audio_id": "iJoXNaK_Lb8", "text": {"iJoXNaK_Lb8-00000-00000000-00010806": "Walk Away | Fast Sampled Freestyle Type Trap Beat 2022 - Freeestyle Instrumental - #typebeat #instru"}}, {"audio_id": "iJ_sGjaVKd0", "text": {"iJ_sGjaVKd0-00000-00002842-00003242": "It's 100% go go go and there is a lot of cross-training involved.", "iJ_sGjaVKd0-00001-00003272-00003972": "It is a 40 man crew, normally a ship this size has 150-200 people, so there is a lot", "iJ_sGjaVKd0-00002-00004059-00004348": "of work to be done on here.", "iJ_sGjaVKd0-00003-00004348-00004878": "The commissioning crew and the work we do here will have an impact on this ship 20 years", "iJ_sGjaVKd0-00004-00004878-00005067": "from now.", "iJ_sGjaVKd0-00005-00005067-00005717": "These ship's have the ability to operate in shallow waters other major warship's can't.", "iJ_sGjaVKd0-00006-00005717-00006303": "This is on of the most versatile, most valuable ship's in the Navy.", "iJ_sGjaVKd0-00007-00006303-00006872": "Fast, agile and adaptable platform that we can bring in different modules to perform", "iJ_sGjaVKd0-00008-00006872-00007042": "different mission.", "iJ_sGjaVKd0-00009-00007042-00007522": "Underway is a lot simpler to manage things, you do not have to worry about manning so", "iJ_sGjaVKd0-00010-00007522-00007761": "many spaces, getting out and checking so many things. It", "iJ_sGjaVKd0-00011-00007761-00008261": "is all at a counsel, or all at the click of a mouse button.", "iJ_sGjaVKd0-00012-00008261-00008813": "If somebody is looking to get out of their comfort zone, and do something different,", "iJ_sGjaVKd0-00013-00008813-00008964": "this is absolutely the program to get into."}}, {"audio_id": "iJFZlkkKyr0", "text": {"iJFZlkkKyr0-00000-00002496-00002750": "And we say goodbye, to the north island.", "iJFZlkkKyr0-00001-00005246-00005548": "So we have enjoyed a 3 hours boat ride.", "iJFZlkkKyr0-00002-00005768-00005880": "I'm so tierd,", "iJFZlkkKyr0-00003-00005886-00006138": "I'm going to sleep the shit out of the next bed I come to.", "iJFZlkkKyr0-00004-00006148-00006354": "But we are in the town Picton,", "iJFZlkkKyr0-00005-00006604-00006790": "I'm going to turn off the camera here", "iJFZlkkKyr0-00006-00006790-00006986": "because I'm going to sleep.", "iJFZlkkKyr0-00007-00007559-00007840": "So a whole week later then.", "iJFZlkkKyr0-00008-00007840-00008138": "You may wonder why we haven't updated anything but", "iJFZlkkKyr0-00009-00008138-00008280": "let me explain.", "iJFZlkkKyr0-00010-00008280-00008388": "It's a lot to explain.", "iJFZlkkKyr0-00011-00008388-00008612": "Like why is there a cake here?", "iJFZlkkKyr0-00012-00008612-00009088": "We are in a town called Blenheim.", "iJFZlkkKyr0-00013-00009216-00009474": "A city you don't do anything in, seriously.", "iJFZlkkKyr0-00014-00009474-00009746": "They have work here so that's why we are here.", "iJFZlkkKyr0-00015-00009746-00009988": "Now what kind of fancy job do we do?", "iJFZlkkKyr0-00016-00009988-00010188": "We are opening mussels.", "iJFZlkkKyr0-00017-00010252-00010394": "A few 1000 a day.", "iJFZlkkKyr0-00018-00010394-00010748": "Every hour we open 700+ mussels.", "iJFZlkkKyr0-00019-00010798-00011190": "So yeah, be grateful next time you eat a mussel.", "iJFZlkkKyr0-00020-00011222-00011494": "Explanation number 2 about the cake", "iJFZlkkKyr0-00021-00011494-00011836": "is because it's my birthday when filming this.", "iJFZlkkKyr0-00022-00012668-00012894": "Well, it's fun being 25.", "iJFZlkkKyr0-00023-00012974-00013102": "Half-way to 50.", "iJFZlkkKyr0-00024-00013136-00013600": "Probably the first and only time 20 people in", "iJFZlkkKyr0-00025-00013618-00013726": "Chernobyl,", "iJFZlkkKyr0-00026-00013804-00013968": "breaking bad,", "iJFZlkkKyr0-00027-00014012-00014452": "coronavirus suits sings Happy birthday to me.", "iJFZlkkKyr0-00028-00014452-00014772": "But I'll have this cake, for breakfast.", "iJFZlkkKyr0-00029-00014984-00015569": "If there is something I miss it has to be the bakery in Sweden.", "iJFZlkkKyr0-00030-00015934-00016308": "Let see, I think I'm going to pick up the camera tomorrow.", "iJFZlkkKyr0-00031-00016308-00016374": "Because tomorrow", "iJFZlkkKyr0-00032-00016374-00016538": "we are meeting up with Lukas and Josef,", "iJFZlkkKyr0-00033-00016538-00016710": "they are also here on the south.", "iJFZlkkKyr0-00034-00016710-00016994": "So finally I can put you to use.", "iJFZlkkKyr0-00035-00017102-00017376": "Yeah because here it's not much to film.", "iJFZlkkKyr0-00036-00017518-00017726": "Should I put it on time lapse?", "iJFZlkkKyr0-00037-00017770-00017876": "Yeah, lets do that.", "iJFZlkkKyr0-00038-00019664-00019864": "I miss you guys <3", "iJFZlkkKyr0-00039-00023366-00023568": "Here is a sandwich box.", "iJFZlkkKyr0-00040-00023692-00023852": "Water bottle.", "iJFZlkkKyr0-00041-00023954-00024076": "and a bag.", "iJFZlkkKyr0-00042-00024128-00024366": "and a big water bottle.", "iJFZlkkKyr0-00043-00024574-00024866": "and we have Micke in the front seat.", "iJFZlkkKyr0-00044-00024944-00025150": "So it's the day after.", "iJFZlkkKyr0-00045-00025150-00025590": "And we are going to meet Josef and Lukas.", "iJFZlkkKyr0-00046-00025638-00025920": "And we are going to look for whales.", "iJFZlkkKyr0-00047-00025922-00026070": "Haven't slept for shit.", "iJFZlkkKyr0-00048-00026070-00026230": "When did you go to bed?", "iJFZlkkKyr0-00049-00026230-00026404": "I came into the room like 7 o'clock.", "iJFZlkkKyr0-00050-00026404-00026466": "7?", "iJFZlkkKyr0-00051-00026562-00026764": "The Germans just kept on going.", "iJFZlkkKyr0-00052-00026836-00026942": "They are crazy.", "iJFZlkkKyr0-00053-00026942-00027248": "But yeah how long is the drive. 1 hour?", "iJFZlkkKyr0-00054-00027248-00027310": "2.", "iJFZlkkKyr0-00055-00027310-00027410": "2 hours...", "iJFZlkkKyr0-00056-00027495-00027680": "pull me back", "iJFZlkkKyr0-00057-00027680-00027930": "how good would it be with a subway.", "iJFZlkkKyr0-00058-00027989-00028166": "And Subway it is!", "iJFZlkkKyr0-00059-00028224-00028574": "Let's eat the sub and I'll see you in", "iJFZlkkKyr0-00060-00028574-00028900": "Toby's magic bag or what the place is called.", "iJFZlkkKyr0-00061-00030258-00030424": "you only get this chance once.", "iJFZlkkKyr0-00062-00030424-00030552": "aah super fun.", "iJFZlkkKyr0-00063-00030566-00030712": "Can't you see what I'm eating.", "iJFZlkkKyr0-00064-00030712-00031024": "Fing red stuff and with a new white t-shirt,", "iJFZlkkKyr0-00065-00031024-00031204": "it's a nightmare.", "iJFZlkkKyr0-00066-00031204-00031439": "I'm going to make a mess either way.", "iJFZlkkKyr0-00067-00031580-00031748": "Welcome back boys.", "iJFZlkkKyr0-00068-00031748-00031882": "Thanks.", "iJFZlkkKyr0-00069-00032150-00032395": "So no boat ride today,", "iJFZlkkKyr0-00070-00032520-00032756": "In this country this is bad weather,", "iJFZlkkKyr0-00071-00032756-00032948": "so they had to cancel.", "iJFZlkkKyr0-00072-00032990-00033098": "let's get drunk insted,", "iJFZlkkKyr0-00073-00033098-00033332": "so we don't know how to get back home!", "iJFZlkkKyr0-00074-00033478-00033668": "'But we are now in Kaikoura.", "iJFZlkkKyr0-00075-00033668-00033806": "Ah you remembered the name.", "iJFZlkkKyr0-00076-00033806-00034180": "Yeah because it on the sign and i looked at it.", "iJFZlkkKyr0-00077-00034228-00034460": "They always have so difficult names here.", "iJFZlkkKyr0-00078-00034460-00034954": "It's either British or so mouri you can't pronounce it.", "iJFZlkkKyr0-00079-00034954-00035226": "You were going to learn mouri, how's it going?", "iJFZlkkKyr0-00080-00035226-00035312": "Not good,", "iJFZlkkKyr0-00081-00035312-00035786": "Mata is fish. Mapu is hook so, mata mapu is fish hook.", "iJFZlkkKyr0-00082-00035888-00036242": "I learned that in Whangarei,", "iJFZlkkKyr0-00083-00036302-00036542": "I read a sign that said fish hook.", "iJFZlkkKyr0-00084-00036636-00036780": "How was the food?", "iJFZlkkKyr0-00085-00036840-00036956": "Really good.", "iJFZlkkKyr0-00086-00037026-00037078": "Nice.", "iJFZlkkKyr0-00087-00037168-00037486": "You know the food is good when you have bib on.", "iJFZlkkKyr0-00088-00037486-00037684": "But Micke is on a diet today.", "iJFZlkkKyr0-00089-00037684-00037808": "yeaha beer diet.", "iJFZlkkKyr0-00090-00037808-00038124": "But beer kills corona I heard.", "iJFZlkkKyr0-00091-00038342-00038438": "What?", "iJFZlkkKyr0-00092-00038496-00039040": "you look like the kid in middle school that shows you what was for lunch.", "iJFZlkkKyr0-00093-00039194-00039482": "Bolognese everywhere.", "iJFZlkkKyr0-00094-00039712-00039960": "We have to figure out what to do here.", "iJFZlkkKyr0-00095-00039960-00040118": "Yeah flex with a helicopter.", "iJFZlkkKyr0-00096-00040170-00040374": "That sounded so wrong...", "iJFZlkkKyr0-00097-00044766-00044976": "No, thats just sick.", "iJFZlkkKyr0-00098-00044976-00045138": "Water break guys!", "iJFZlkkKyr0-00099-00045436-00045658": "Whats the score? 2-0 to us?", "iJFZlkkKyr0-00100-00045774-00045988": "Yeah exactly how it's not.", "iJFZlkkKyr0-00101-00046072-00046370": "As I said, you have no power over my edits.", "iJFZlkkKyr0-00102-00047918-00048044": "Time to drink beer.", "iJFZlkkKyr0-00103-00048362-00048556": "Josef are you happy now?", "iJFZlkkKyr0-00104-00048698-00048882": "Ice cream is yummy.", "iJFZlkkKyr0-00105-00051466-00051808": "We heard that they have a potable toilet in here.", "iJFZlkkKyr0-00106-00052240-00052500": "So here is where you take a shit?", "iJFZlkkKyr0-00107-00052526-00052582": "Look!", "iJFZlkkKyr0-00108-00052582-00052726": "There is Josefe's poop.", "iJFZlkkKyr0-00109-00052726-00052884": "Time to ride a luxury car.", "iJFZlkkKyr0-00110-00052884-00053096": "What are my drone doing here?", "iJFZlkkKyr0-00111-00053224-00053367": "Hello there.", "iJFZlkkKyr0-00112-00053905-00054191": "HOLD ON! THE BOAT IS TIPPING!", "iJFZlkkKyr0-00113-00056905-00057288": "Give us a call if you're going to Bali.", "iJFZlkkKyr0-00114-00057586-00057936": "Bali bali bali bali bali.", "iJFZlkkKyr0-00115-00058100-00058276": "You guys have fun here.", "iJFZlkkKyr0-00116-00058276-00058452": "Have anything motivating to say?", "iJFZlkkKyr0-00117-00058496-00058596": "Motivating?", "iJFZlkkKyr0-00118-00060990-00061052": "Okey,", "iJFZlkkKyr0-00119-00061078-00061278": "so now when i'm sitting here i can explain why", "iJFZlkkKyr0-00120-00061278-00061424": "we haven't filmed anything,", "iJFZlkkKyr0-00121-00061424-00061750": "we've been here for 3 weeks But haven't filmed a day.", "iJFZlkkKyr0-00122-00061774-00061888": "So I'm going to do an update.", "iJFZlkkKyr0-00123-00061888-00062148": "We are working in a mussel factory", "iJFZlkkKyr0-00124-00062148-00062524": "and everyone here is hating it and our last day is today.", "iJFZlkkKyr0-00125-00062524-00062802": "I don't think we would be able to cope with this", "iJFZlkkKyr0-00126-00062838-00063186": "if it wasn't for all the people who live here.", "iJFZlkkKyr0-00127-00067408-00067650": "Some shit cleans the stomach - lite skit rensar magen", "iJFZlkkKyr0-00128-00067862-00068070": "F*cking as*hole - J*vla r*vhål.", "iJFZlkkKyr0-00129-00071482-00071772": "Okey, we can take this in Swedish again.", "iJFZlkkKyr0-00130-00071856-00072184": "If you're wondering how the pizza came here and all.", "iJFZlkkKyr0-00131-00072184-00072494": "It started with me looking for my package from Sweden,", "iJFZlkkKyr0-00132-00072494-00072624": "hadn't arrived yet.", "iJFZlkkKyr0-00133-00072624-00072786": "So I turn around...", "iJFZlkkKyr0-00134-00072884-00073266": "'And i notice we have a flat tire on the same tire as before...", "iJFZlkkKyr0-00135-00073266-00073388": "Unscrewed it", "iJFZlkkKyr0-00136-00073518-00073770": "and went to the tire shop.", "iJFZlkkKyr0-00137-00073818-00074080": "Then i though, Dominoes is on the other side so", "iJFZlkkKyr0-00138-00074080-00074470": "might as well go grab a pizza and", "iJFZlkkKyr0-00139-00074470-00074798": "head back to the hostel and eat it as breakfast.", "iJFZlkkKyr0-00140-00075182-00075436": "If we dont see each other for a while,", "iJFZlkkKyr0-00141-00075498-00075636": "Take care and", "iJFZlkkKyr0-00142-00075636-00075752": "I see you next time<3", "iJFZlkkKyr0-00143-00076430-00077028": "Thanks for watching, plz share because we are going international next vlog"}}, {"audio_id": "iJH4fZly7HM", "text": {"iJH4fZly7HM-00000-00000000-00000216": "(singing room battle) What about the first place?!", "iJH4fZly7HM-00001-00000352-00000476": "What about the first place?!", "iJH4fZly7HM-00002-00000476-00000662": "It'll be released in 60 seconds.", "iJH4fZly7HM-00003-00000940-00001052": "Manager", "iJH4fZly7HM-00004-00001052-00001140": "Who's the winner?", "iJH4fZly7HM-00005-00001174-00001436": "a total of 191 points", "iJH4fZly7HM-00006-00001484-00001632": "voted by the people", "iJH4fZly7HM-00007-00001662-00001838": "Park Jae Chan~", "iJH4fZly7HM-00008-00002156-00002476": "Jae-chan's singing room, which showed a professional side by side", "iJH4fZly7HM-00009-00002516-00002958": "This is what Ari and I want together.", "iJH4fZly7HM-00010-00003062-00003142": "Moon Ik", "iJH4fZly7HM-00011-00003142-00003236": "Yeah.", "iJH4fZly7HM-00012-00003236-00003297": "Pardon?", "iJH4fZly7HM-00013-00003297-00003361": "(Come forward)", "iJH4fZly7HM-00014-00003474-00003552": "(Come on)", "iJH4fZly7HM-00015-00003664-00003782": "You want to come out?", "iJH4fZly7HM-00016-00003782-00003928": "It's over. One wish is over!", "iJH4fZly7HM-00017-00004024-00004126": "Oh, I'm scared.", "iJH4fZly7HM-00018-00004400-00004556": "Give it a he charms", "iJH4fZly7HM-00019-00004556-00004724": "Give it a he charms", "iJH4fZly7HM-00020-00004950-00005090": "Huh? Can't you look at the camera?", "iJH4fZly7HM-00021-00005112-00005518": "Your Highness, I miss young and cute.", "iJH4fZly7HM-00022-00005636-00006008": "Then try young and cute.", "iJH4fZly7HM-00023-00006058-00006242": "No! That's not enough.", "iJH4fZly7HM-00024-00006256-00006508": "Your Highness, do not listen to him.", "iJH4fZly7HM-00025-00006581-00006923": "Then try young and cute.", "iJH4fZly7HM-00026-00007359-00007454": "Your Highness", "iJH4fZly7HM-00027-00007836-00008118": "Your Highness, hit him.", "iJH4fZly7HM-00028-00008492-00008774": "Our people want an encore.", "iJH4fZly7HM-00029-00008774-00009000": "Not an encore.", "iJH4fZly7HM-00030-00009000-00009242": "Not an encore. Guys.", "iJH4fZly7HM-00031-00009410-00009786": "Then I'll watch Moon Ik's aegyo encore and end it.", "iJH4fZly7HM-00032-00009870-00010004": "Your Highness, thank you.", "iJH4fZly7HM-00033-00010074-00010274": "Am I the ending fairy?", "iJH4fZly7HM-00034-00010344-00010446": "Then...", "iJH4fZly7HM-00035-00011540-00011980": "(the attitude of dealing with a colleague's business.)", "iJH4fZly7HM-00036-00011980-00012330": "You are now watching the cute act of 20-year-old Jang Moon-ik.", "iJH4fZly7HM-00037-00012366-00012568": "I cringe at first?", "iJH4fZly7HM-00038-00012568-00012928": "You're doing great when I see you playing again.", "iJH4fZly7HM-00039-00012960-00013062": "It's an honor.", "iJH4fZly7HM-00040-00013062-00013197": "I'm honored.", "iJH4fZly7HM-00041-00013246-00013856": "It's almost time to finish watching Moon Ik Aegyo already.", "iJH4fZly7HM-00042-00013869-00014046": "Please show me one more time.", "iJH4fZly7HM-00043-00014062-00014262": "Oh, guys, no.", "iJH4fZly7HM-00044-00014262-00014482": "I will not see this as the king's authority.", "iJH4fZly7HM-00045-00014500-00014700": "This is hard on me.", "iJH4fZly7HM-00046-00014874-00015247": "It's really time to wrap this up.", "iJH4fZly7HM-00047-00015272-00015669": "Please show your love for Dongkids.", "iJH4fZly7HM-00048-00015686-00016144": "Ara TV is the love of idols."}}, {"audio_id": "iJKdreU_Agu", "text": {"iJKdreU_Agu-00000-00000520-00001176": "It's with the school of health at Teesside and so all healthcare students who will move on to", "iJKdreU_Agu-00001-00001176-00001816": "get jobs but a good chunk of them will want to get dubs locally so about three four years in", "iJKdreU_Agu-00002-00001816-00002424": "I started meeting people in practice who then tell me about how I gave them a speech in class", "iJKdreU_Agu-00003-00002424-00003120": "or um I interviewed them get into their course or when they were on placement like they were um", "iJKdreU_Agu-00004-00003215-00003688": "with the nurses or the physios that were attending to me at some point and that kind of thing", "iJKdreU_Agu-00005-00003688-00004152": "I have no idea who they are but then just seeing that tangible evidence of", "iJKdreU_Agu-00006-00004256-00004872": "the like someone who I've had a canned in shape and limited like a better person someone", "iJKdreU_Agu-00007-00004872-00005344": "who's giving back to society and I'm benefiting directly from what that and what they're giving", "iJKdreU_Agu-00008-00005344-00005808": "society that's that's really that I was really rewarded and every everything happened was like", "iJKdreU_Agu-00009-00005808-00006608": "i got kitty inside actually I come to a kid again and it's awesome"}}, {"audio_id": "iJWjrVJJOXg", "text": {"iJWjrVJJOXg-00000-00000082-00001200": "[Music]", "iJWjrVJJOXg-00001-00001200-00001538": "When we visited with Dr. Pete Sexton we", "iJWjrVJJOXg-00002-00001538-00001770": "asked him how he reached out to farmers", "iJWjrVJJOXg-00003-00001770-00002076": "considering a transition to no till I", "iJWjrVJJOXg-00004-00002076-00002331": "think for us that's kind of the", "iJWjrVJJOXg-00005-00002331-00002523": "sixty-four-thousand-dollar question i", "iJWjrVJJOXg-00006-00002523-00002991": "don't really have a resolve Buz. Yeah am I", "iJWjrVJJOXg-00007-00002991-00003231": "guess from what I from the data we've", "iJWjrVJJOXg-00008-00003231-00003507": "seen from our trials over the years and", "iJWjrVJJOXg-00009-00003507-00003864": "no till yields as well as tilled system", "iJWjrVJJOXg-00010-00003864-00004116": "and sometimes if we have a really wet", "iJWjrVJJOXg-00011-00004116-00004509": "spring wet June we'll see a little bit", "iJWjrVJJOXg-00012-00004509-00004739": "lower yield with no till. If we have a", "iJWjrVJJOXg-00013-00004739-00004982": "really hot dry August we'll see much", "iJWjrVJJOXg-00014-00004982-00005237": "better yield with no-till .But over time", "iJWjrVJJOXg-00015-00005237-00005493": "over the years it's kind of a wash and", "iJWjrVJJOXg-00016-00005493-00005835": "then you have much lower cost so my", "iJWjrVJJOXg-00017-00005835-00006137": "approach with it with somebody that's", "iJWjrVJJOXg-00018-00006137-00006291": "interested in it would say you know this", "iJWjrVJJOXg-00019-00006291-00006606": "your advantage is you're going to have a", "iJWjrVJJOXg-00020-00006606-00006852": "more stable system in terms of", "iJWjrVJJOXg-00021-00006852-00007229": "protecting the soil in terms of you know", "iJWjrVJJOXg-00022-00007229-00007565": "if you have a sharp thunderstorm in May", "iJWjrVJJOXg-00023-00007565-00007752": "and June you keep a lot more the soil", "iJWjrVJJOXg-00024-00007752-00008057": "there and probably the moisture as well", "iJWjrVJJOXg-00025-00008057-00008202": "and the moisture as  well", "iJWjrVJJOXg-00026-00008202-00008421": "yeah so it's good for your soil it costs", "iJWjrVJJOXg-00027-00008421-00008649": "less and over time in an", "iJWjrVJJOXg-00028-00008649-00008822": "individual you it might help you might", "iJWjrVJJOXg-00029-00008822-00009068": "not but over on average you really not", "iJWjrVJJOXg-00030-00009068-00009482": "losing anything in terms of yield ok", "iJWjrVJJOXg-00031-00009482-00009714": "then what does transition to no-till", "iJWjrVJJOXg-00032-00009714-00009968": "look like and how do we navigate it", "iJWjrVJJOXg-00033-00009968-00010197": "well that's exactly the subject of our", "iJWjrVJJOXg-00034-00010197-00010449": "next video as we continue our discussion", "iJWjrVJJOXg-00035-00010449-00012692": "with Dr.Sexton see you all soon."}}, {"audio_id": "iJZw4ZZAq7Y", "text": {"iJZw4ZZAq7Y-00000-00000300-00000666": "London, go and get Wendy and Audrey. tell them to come in now", "iJZw4ZZAq7Y-00002-00003066-00003265": "come in", "iJZw4ZZAq7Y-00005-00005054-00005277": "London, Wendy can't come in.", "iJZw4ZZAq7Y-00006-00005277-00005864": "tell them they can come in", "iJZw4ZZAq7Y-00007-00006230-00006670": "There's no motorcycle outside now.", "iJZw4ZZAq7Y-00008-00006970-00007250": "The motorcycle passed now", "iJZw4ZZAq7Y-00009-00007909-00008476": "There's no more scary sound outside", "iJZw4ZZAq7Y-00010-00008580-00009186": "Wendy was surprised by the motorcycle noise while we were venting the air.", "iJZw4ZZAq7Y-00011-00009486-00010010": "London is so brave~ London is cool~ Were you not surprised at all?", "iJZw4ZZAq7Y-00012-00010010-00010471": "This is nothing~", "iJZw4ZZAq7Y-00013-00010471-00011040": "I was so scared.", "iJZw4ZZAq7Y-00014-00011681-00012146": "If you close the window, I'll go in."}}, {"audio_id": "iL4FNQHlTUu", "text": {"iL4FNQHlTUu-00000-00000617-00000735": "Sehwag: Namaskaram Sadhguru!", "iL4FNQHlTUu-00001-00000735-00001174": "I want to know truth about our Indian caste system.", "iL4FNQHlTUu-00002-00001174-00001679": "How can we ensure more inclusiveness and equality?", "iL4FNQHlTUu-00003-00001679-00001993": "Sadhguru: Namaskaram Viru.", "iL4FNQHlTUu-00004-00001993-00002352": "This system essentially began as division of labor.", "iL4FNQHlTUu-00005-00002352-00002932": "For a society to function, a certain number of people in the population", "iL4FNQHlTUu-00006-00002932-00003532": "must do variety of skills and artisans,  somebody should take care of administration,", "iL4FNQHlTUu-00007-00003532-00004067": "somebody should take care of  education and spiritual process for the community.", "iL4FNQHlTUu-00008-00004067-00004308": "Like this they made four basic divisions.", "iL4FNQHlTUu-00009-00004308-00004680": "Over a period of time they became further and further divided,", "iL4FNQHlTUu-00010-00004680-00005284": "not essentially as a discriminatory process but more as a division of labor", "iL4FNQHlTUu-00011-00005284-00005934": "and also we must understand in ancient times, when there were no engineering schools and medical schools,", "iL4FNQHlTUu-00012-00005934-00006586": "if your father was a carpenter, you learnt carpentry at home from childhood and became a good carpenter.", "iL4FNQHlTUu-00013-00006586-00007190": "So skills were transmitted from generation to generation by maintaining this caste system.", "iL4FNQHlTUu-00014-00007190-00008064": "But unfortunately somewhere along the way, a goldsmith starts thinking he is superior to a blacksmith", "iL4FNQHlTUu-00015-00008064-00008558": "– though a blacksmith’s work may be far more useful to the society than a goldsmith’s,", "iL4FNQHlTUu-00016-00008558-00008922": "somehow one thinks he is superior to the other", "iL4FNQHlTUu-00017-00008922-00009335": "and over generations this superiority gets established.", "iL4FNQHlTUu-00018-00009335-00009692": "all kinds of exploitative processes happened", "iL4FNQHlTUu-00019-00009692-00010300": "and it came to a place where caste system almost began to manifest itself", "iL4FNQHlTUu-00020-00010300-00010721": "or it has manifested itself like a partheid.", "iL4FNQHlTUu-00021-00010721-00011232": "Still in many villages in India the people who are considered to be lower caste", "iL4FNQHlTUu-00022-00011232-00011850": "are what you call as Dalits  don’t even have basic human rights in many villages", "iL4FNQHlTUu-00023-00011850-00012330": "though much has changed in the last twenty five thirty years", "iL4FNQHlTUu-00024-00012330-00013031": "still many very horribly undesirable things  keep happening in our country.", "iL4FNQHlTUu-00025-00013031-00013590": "The only way out of this is one thing is it’s not relevant to these times", "iL4FNQHlTUu-00026-00013590-00013991": "because skills can be transmitted in many different ways", "iL4FNQHlTUu-00027-00013991-00014347": "we have educational institutions we have technological institutions,", "iL4FNQHlTUu-00028-00014347-00014937": "so this family transference of skills is not the way it is going anymore", "iL4FNQHlTUu-00029-00014937-00015347": "but there is one context, that is of social security.", "iL4FNQHlTUu-00030-00015347-00015604": "People take care of their own clan and their caste.", "iL4FNQHlTUu-00031-00015604-00015988": "They will always reach out to people who are in trouble in their caste.", "iL4FNQHlTUu-00032-00015988-00016229": "This kind of social security is there.", "iL4FNQHlTUu-00033-00016229-00016828": "So it is very important that we bring a  nationwide social security system,", "iL4FNQHlTUu-00034-00016828-00017417": "and an education system which will transmit skills to everybody according to their aptitude.", "iL4FNQHlTUu-00035-00017417-00017920": "Once that happens, I think  caste system will die a natural death."}}, {"audio_id": "iLyGIHowiYk", "text": {"iLyGIHowiYk-00000-00000000-00000501": "Welcome to my video", "iLyGIHowiYk-00001-00000505-00001000": "Thank you for this video view", "iLyGIHowiYk-00002-00001000-00001508": "Like, sub, share, support my channel.", "iLyGIHowiYk-00003-00001516-00002000": "Thank you very much"}}, {"audio_id": "iLzT9p8PJTg", "text": {"iLzT9p8PJTg-00000-00000010-00000190": "LOCAL NEWS, WEA", "iLzT9p8PJTg-00001-00000190-00000196": "LOCAL NEWS, WEA", "iLzT9p8PJTg-00002-00000196-00000557": "LOCAL NEWS, WEA >>> NOW THAT THE HOLIDAY SEASON", "iLzT9p8PJTg-00003-00000557-00000563": "LOCAL NEWS, WEA >>> NOW THAT THE HOLIDAY SEASON", "iLzT9p8PJTg-00004-00000563-00000623": "LOCAL NEWS, WEA >>> NOW THAT THE HOLIDAY SEASON  IS IN FULL SWING, SO IS THE", "iLzT9p8PJTg-00005-00000623-00000630": ">>> NOW THAT THE HOLIDAY SEASON  IS IN FULL SWING, SO IS THE", "iLzT9p8PJTg-00006-00000630-00000714": ">>> NOW THAT THE HOLIDAY SEASON  IS IN FULL SWING, SO IS THE ANNUAL KETTLE CAMPAIGN FOR THE", "iLzT9p8PJTg-00007-00000714-00000720": "IS IN FULL SWING, SO IS THE ANNUAL KETTLE CAMPAIGN FOR THE", "iLzT9p8PJTg-00008-00000720-00000877": "IS IN FULL SWING, SO IS THE ANNUAL KETTLE CAMPAIGN FOR THE  SALVATION ARMY, BUT MANY", "iLzT9p8PJTg-00009-00000877-00000884": "ANNUAL KETTLE CAMPAIGN FOR THE  SALVATION ARMY, BUT MANY", "iLzT9p8PJTg-00010-00000884-00001037": "ANNUAL KETTLE CAMPAIGN FOR THE  SALVATION ARMY, BUT MANY  LOCATIONS ARE IN NEED OF BELL", "iLzT9p8PJTg-00011-00001037-00001044": "SALVATION ARMY, BUT MANY  LOCATIONS ARE IN NEED OF BELL", "iLzT9p8PJTg-00012-00001044-00001147": "SALVATION ARMY, BUT MANY  LOCATIONS ARE IN NEED OF BELL  RINGERS.", "iLzT9p8PJTg-00013-00001147-00001154": "LOCATIONS ARE IN NEED OF BELL  RINGERS.", "iLzT9p8PJTg-00014-00001154-00001297": "LOCATIONS ARE IN NEED OF BELL  RINGERS. IN BEMIDJI THERE ARE SIX KETTLE", "iLzT9p8PJTg-00015-00001297-00001304": "RINGERS. IN BEMIDJI THERE ARE SIX KETTLE", "iLzT9p8PJTg-00016-00001304-00001398": "RINGERS. IN BEMIDJI THERE ARE SIX KETTLE  LOCATIONS THAT ARE IN NEED", "iLzT9p8PJTg-00017-00001398-00001404": "IN BEMIDJI THERE ARE SIX KETTLE  LOCATIONS THAT ARE IN NEED", "iLzT9p8PJTg-00018-00001404-00001514": "IN BEMIDJI THERE ARE SIX KETTLE  LOCATIONS THAT ARE IN NEED OF BELL RINGERS.", "iLzT9p8PJTg-00019-00001514-00001521": "LOCATIONS THAT ARE IN NEED OF BELL RINGERS.", "iLzT9p8PJTg-00020-00001521-00001674": "LOCATIONS THAT ARE IN NEED OF BELL RINGERS. VOLUNTEERS ARE NEEDED TO WORK", "iLzT9p8PJTg-00021-00001674-00001681": "OF BELL RINGERS. VOLUNTEERS ARE NEEDED TO WORK", "iLzT9p8PJTg-00022-00001681-00001885": "OF BELL RINGERS. VOLUNTEERS ARE NEEDED TO WORK  TWO-HOUR SHIFTS NOW THROUGH", "iLzT9p8PJTg-00023-00001885-00001891": "VOLUNTEERS ARE NEEDED TO WORK  TWO-HOUR SHIFTS NOW THROUGH", "iLzT9p8PJTg-00024-00001891-00001981": "VOLUNTEERS ARE NEEDED TO WORK  TWO-HOUR SHIFTS NOW THROUGH CHRISTMAS FROM 9:00 A.M. UNTIL", "iLzT9p8PJTg-00025-00001981-00001988": "TWO-HOUR SHIFTS NOW THROUGH CHRISTMAS FROM 9:00 A.M. UNTIL", "iLzT9p8PJTg-00026-00001988-00002092": "TWO-HOUR SHIFTS NOW THROUGH CHRISTMAS FROM 9:00 A.M. UNTIL  7:00 P.M.", "iLzT9p8PJTg-00027-00002092-00002098": "CHRISTMAS FROM 9:00 A.M. UNTIL  7:00 P.M.", "iLzT9p8PJTg-00028-00002098-00002252": "CHRISTMAS FROM 9:00 A.M. UNTIL  7:00 P.M. EVEN THOUGH SOME LOCATIONS HAVE", "iLzT9p8PJTg-00029-00002252-00002258": "7:00 P.M. EVEN THOUGH SOME LOCATIONS HAVE", "iLzT9p8PJTg-00030-00002258-00002358": "7:00 P.M. EVEN THOUGH SOME LOCATIONS HAVE  ALREADY BEEN RINGING, THE", "iLzT9p8PJTg-00031-00002358-00002365": "EVEN THOUGH SOME LOCATIONS HAVE  ALREADY BEEN RINGING, THE", "iLzT9p8PJTg-00032-00002365-00002569": "EVEN THOUGH SOME LOCATIONS HAVE  ALREADY BEEN RINGING, THE NEED IS NOW, AND THERE ARE", "iLzT9p8PJTg-00033-00002569-00002575": "ALREADY BEEN RINGING, THE NEED IS NOW, AND THERE ARE", "iLzT9p8PJTg-00034-00002575-00002986": "ALREADY BEEN RINGING, THE NEED IS NOW, AND THERE ARE  PLENTY OF SHIFTS TO FILL.", "iLzT9p8PJTg-00035-00002986-00002992": "NEED IS NOW, AND THERE ARE  PLENTY OF SHIFTS TO FILL.", "iLzT9p8PJTg-00036-00002992-00003313": "NEED IS NOW, AND THERE ARE  PLENTY OF SHIFTS TO FILL. >> USUALLY IT TAKES A COUPLE", "iLzT9p8PJTg-00037-00003313-00003319": "PLENTY OF SHIFTS TO FILL. >> USUALLY IT TAKES A COUPLE", "iLzT9p8PJTg-00038-00003319-00003543": "PLENTY OF SHIFTS TO FILL. >> USUALLY IT TAKES A COUPLE  WEEKS INTO DECEMBER MAYBE TO", "iLzT9p8PJTg-00039-00003543-00003550": ">> USUALLY IT TAKES A COUPLE  WEEKS INTO DECEMBER MAYBE TO", "iLzT9p8PJTg-00040-00003550-00003747": ">> USUALLY IT TAKES A COUPLE  WEEKS INTO DECEMBER MAYBE TO  START MORE SO THE RINGING.", "iLzT9p8PJTg-00041-00003747-00003753": "WEEKS INTO DECEMBER MAYBE TO  START MORE SO THE RINGING.", "iLzT9p8PJTg-00042-00003753-00004003": "WEEKS INTO DECEMBER MAYBE TO  START MORE SO THE RINGING. WE DID HAVE SOME RINGING OVER", "iLzT9p8PJTg-00043-00004003-00004010": "START MORE SO THE RINGING. WE DID HAVE SOME RINGING OVER", "iLzT9p8PJTg-00044-00004010-00004280": "START MORE SO THE RINGING. WE DID HAVE SOME RINGING OVER  BLACK FRIDAY AND THE DAY BEFORE", "iLzT9p8PJTg-00045-00004280-00004287": "WE DID HAVE SOME RINGING OVER  BLACK FRIDAY AND THE DAY BEFORE", "iLzT9p8PJTg-00046-00004287-00004501": "WE DID HAVE SOME RINGING OVER  BLACK FRIDAY AND THE DAY BEFORE  THANKSGIVING, BUT MOST OF THEM", "iLzT9p8PJTg-00047-00004501-00004507": "BLACK FRIDAY AND THE DAY BEFORE  THANKSGIVING, BUT MOST OF THEM", "iLzT9p8PJTg-00048-00004507-00004584": "BLACK FRIDAY AND THE DAY BEFORE  THANKSGIVING, BUT MOST OF THEM  START THE SECOND WEEK IN", "iLzT9p8PJTg-00049-00004584-00004591": "THANKSGIVING, BUT MOST OF THEM  START THE SECOND WEEK IN", "iLzT9p8PJTg-00050-00004591-00004738": "THANKSGIVING, BUT MOST OF THEM  START THE SECOND WEEK IN  DECEMBER.", "iLzT9p8PJTg-00051-00004738-00004744": "START THE SECOND WEEK IN  DECEMBER.", "iLzT9p8PJTg-00052-00004744-00004838": "START THE SECOND WEEK IN  DECEMBER. >> MANY KETTLE VOLUNTEERS SAY", "iLzT9p8PJTg-00053-00004838-00004844": "DECEMBER. >> MANY KETTLE VOLUNTEERS SAY", "iLzT9p8PJTg-00054-00004844-00004944": "DECEMBER. >> MANY KETTLE VOLUNTEERS SAY  THE EXPERIENCE IS FUN AND", "iLzT9p8PJTg-00055-00004944-00004951": ">> MANY KETTLE VOLUNTEERS SAY  THE EXPERIENCE IS FUN AND", "iLzT9p8PJTg-00056-00004951-00005105": ">> MANY KETTLE VOLUNTEERS SAY  THE EXPERIENCE IS FUN AND EXTREMELY REWARDING.", "iLzT9p8PJTg-00057-00005105-00005111": "THE EXPERIENCE IS FUN AND EXTREMELY REWARDING.", "iLzT9p8PJTg-00058-00005111-00005318": "THE EXPERIENCE IS FUN AND EXTREMELY REWARDING. LAST YEAR'S KETTLE CAMPAIGN", "iLzT9p8PJTg-00059-00005318-00005325": "EXTREMELY REWARDING. LAST YEAR'S KETTLE CAMPAIGN", "iLzT9p8PJTg-00060-00005325-00005525": "EXTREMELY REWARDING. LAST YEAR'S KETTLE CAMPAIGN  BROUGHT IN OVER $45,000 LOCALLY.", "iLzT9p8PJTg-00061-00005525-00005532": "LAST YEAR'S KETTLE CAMPAIGN  BROUGHT IN OVER $45,000 LOCALLY.", "iLzT9p8PJTg-00062-00005532-00005632": "LAST YEAR'S KETTLE CAMPAIGN  BROUGHT IN OVER $45,000 LOCALLY. VOLUNTEERS SAY THAT BELL RINGERS", "iLzT9p8PJTg-00063-00005632-00005638": "BROUGHT IN OVER $45,000 LOCALLY. VOLUNTEERS SAY THAT BELL RINGERS", "iLzT9p8PJTg-00064-00005638-00005739": "BROUGHT IN OVER $45,000 LOCALLY. VOLUNTEERS SAY THAT BELL RINGERS ARE A CRUCIAL PART TO THE", "iLzT9p8PJTg-00065-00005739-00005745": "VOLUNTEERS SAY THAT BELL RINGERS ARE A CRUCIAL PART TO THE", "iLzT9p8PJTg-00066-00005745-00006089": "VOLUNTEERS SAY THAT BELL RINGERS ARE A CRUCIAL PART TO THE SUCCESS OF THE CAMPAIGN.", "iLzT9p8PJTg-00067-00006089-00006096": "ARE A CRUCIAL PART TO THE SUCCESS OF THE CAMPAIGN.", "iLzT9p8PJTg-00068-00006096-00006279": "ARE A CRUCIAL PART TO THE SUCCESS OF THE CAMPAIGN. >> SOME LOCATIONS, SOME", "iLzT9p8PJTg-00069-00006279-00006286": "SUCCESS OF THE CAMPAIGN. >> SOME LOCATIONS, SOME", "iLzT9p8PJTg-00070-00006286-00006426": "SUCCESS OF THE CAMPAIGN. >> SOME LOCATIONS, SOME  COMMUNITIES, THEY JUST PUT A", "iLzT9p8PJTg-00071-00006426-00006433": ">> SOME LOCATIONS, SOME  COMMUNITIES, THEY JUST PUT A", "iLzT9p8PJTg-00072-00006433-00006526": ">> SOME LOCATIONS, SOME  COMMUNITIES, THEY JUST PUT A  KETTLE OUT.", "iLzT9p8PJTg-00073-00006526-00006533": "COMMUNITIES, THEY JUST PUT A  KETTLE OUT.", "iLzT9p8PJTg-00074-00006533-00006693": "COMMUNITIES, THEY JUST PUT A  KETTLE OUT. AND WHEN YOU HAVE SOMEBODY THERE", "iLzT9p8PJTg-00075-00006693-00006700": "KETTLE OUT. AND WHEN YOU HAVE SOMEBODY THERE", "iLzT9p8PJTg-00076-00006700-00006853": "KETTLE OUT. AND WHEN YOU HAVE SOMEBODY THERE AT THE KETTLE, AND YOU CAN", "iLzT9p8PJTg-00077-00006853-00006860": "AND WHEN YOU HAVE SOMEBODY THERE AT THE KETTLE, AND YOU CAN", "iLzT9p8PJTg-00078-00006860-00006986": "AND WHEN YOU HAVE SOMEBODY THERE AT THE KETTLE, AND YOU CAN  INTERACT WITH PEOPLE, WE SEEM DO", "iLzT9p8PJTg-00079-00006986-00006993": "AT THE KETTLE, AND YOU CAN  INTERACT WITH PEOPLE, WE SEEM DO", "iLzT9p8PJTg-00080-00006993-00007106": "AT THE KETTLE, AND YOU CAN  INTERACT WITH PEOPLE, WE SEEM DO A WHOLE LOT BETTER.", "iLzT9p8PJTg-00081-00007106-00007113": "INTERACT WITH PEOPLE, WE SEEM DO A WHOLE LOT BETTER.", "iLzT9p8PJTg-00082-00007113-00007213": "INTERACT WITH PEOPLE, WE SEEM DO A WHOLE LOT BETTER. >> FOR MORE INFORMATION ON HOW", "iLzT9p8PJTg-00083-00007213-00007220": "A WHOLE LOT BETTER. >> FOR MORE INFORMATION ON HOW", "iLzT9p8PJTg-00084-00007220-00007310": "A WHOLE LOT BETTER. >> FOR MORE INFORMATION ON HOW  TO GET INVOLVED, WE HAVE POSTED", "iLzT9p8PJTg-00085-00007310-00007317": ">> FOR MORE INFORMATION ON HOW  TO GET INVOLVED, WE HAVE POSTED", "iLzT9p8PJTg-00086-00007317-00007530": ">> FOR MORE INFORMATION ON HOW  TO GET INVOLVED, WE HAVE POSTED CONTACT INFORMATION ON OUR"}}, {"audio_id": "iLBBguflz90", "text": {"iLBBguflz90-00000-00000112-00000832": "welcome to monet cafe and another real time lesson of some lovely little floral paintings in today's", "iLBBguflz90-00001-00000832-00001320": "lesson we'll actually be painting two of these paintings that are a series of nine so be sure to", "iLBBguflz90-00002-00001320-00001839": "go back and check out the previous videos oh and if you haven't subscribed i hope you will for more", "iLBBguflz90-00003-00001839-00002512": "artistic learning and fun all of the nine small two and a half by two and a half inch paintings", "iLBBguflz90-00004-00002512-00003128": "were done on a piece of pastel matte a white piece of pastel matte an excellent surface to receive", "iLBBguflz90-00005-00003128-00003856": "watercolor and pastel the watercolors i use for all nine paintings is the arteza watercolor set", "iLBBguflz90-00006-00003856-00004408": "but you can use whatever you have the reference images are from the paint my photo website", "iLBBguflz90-00007-00004408-00004952": "and i share a lot more about that in the first video you can also find in the first video of the", "iLBBguflz90-00008-00004952-00005488": "series my technique for laying out my surface for the nine paintings now you don't have to", "iLBBguflz90-00009-00005488-00006256": "do it this way but it was kind of fun here is the reference image for painting number three of these", "iLBBguflz90-00010-00006256-00006959": "lovely lavender flowers with a little bee i'm just using a pencil to get in a general sketch and i'm", "iLBBguflz90-00011-00006959-00007495": "speeding up the sketch portion but if you see the video right before this one with this series", "iLBBguflz90-00012-00007552-00008304": "in lesson number two i actually give a little mini tutorial on some simple tips for rendering flowers", "iLBBguflz90-00013-00008304-00008968": "so be sure to check that one out as well once the sketch is complete i'm ready for the watercolor", "iLBBguflz90-00014-00008968-00009696": "now all of these paintings have the same general strategy watercolor first and then pastel i'm also", "iLBBguflz90-00015-00009696-00010200": "zooming in closely here so you can actually see my watercolor selections in this particular arteza", "iLBBguflz90-00016-00010200-00011024": "set this color is called deep ocean blue sorry my watercolor part of my palette is so dirty i", "iLBBguflz90-00017-00011024-00011536": "definitely use the heck out of this set and it's just a lovely blue that i'm going to use", "iLBBguflz90-00018-00011536-00012320": "to do an underpainting that's what this is called when we do watercolor as a base prior to pastel", "iLBBguflz90-00019-00012320-00012744": "i love doing under paintings if you've seen my channel much i have many different strategies", "iLBBguflz90-00020-00012744-00013456": "and techniques and in this case i'm just putting down some pretty blue a cool underpainting and", "iLBBguflz90-00021-00013456-00014016": "i'm letting the water do the work by the way i have a new series on watercolor tutorials coming", "iLBBguflz90-00022-00014016-00014568": "because so many times i use watercolor to begin a painting and i thought it would be neat to give", "iLBBguflz90-00023-00014568-00015304": "some basic watercolor instruction now i'm using another blue here this blue is i'm looking on it", "iLBBguflz90-00024-00015304-00015952": "right now it's oxford blue and see how that's just a deeper blue a little bit more of a cool", "iLBBguflz90-00025-00015952-00016544": "purplish leaning towards purple blue and i'm going to use this color to get in the basic", "iLBBguflz90-00026-00016544-00017176": "little flowers now because i added water first i forgot to mention that you might have seen me", "iLBBguflz90-00027-00017176-00017768": "adding some water to the pastel paper before i even added this light blue and purpley blue", "iLBBguflz90-00028-00017768-00018496": "color and the reason for that is it creates a subtle impressionistic feel do you see how", "iLBBguflz90-00029-00018496-00019160": "the color is just bleeding and blending and is so subdued and that is just one of the", "iLBBguflz90-00030-00019160-00019704": "purposes or advantages of doing an underpainting probably one of the most common questions i get is", "iLBBguflz90-00031-00019704-00020096": "why do you do an underpainting you're just going to cover it up i hear that all the time first of", "iLBBguflz90-00032-00020096-00020848": "all i don't cover it all up and it actually makes a base that gives an impressionistic beginning", "iLBBguflz90-00033-00020848-00021456": "and as you can most likely see here now what i'm using here for this underpainting strategy", "iLBBguflz90-00034-00021456-00022240": "is more of a local color but definitely leaning towards cool colors what do i mean by local color", "iLBBguflz90-00035-00022240-00022648": "that just means the color that's natural to the scene now i know we have a lot of", "iLBBguflz90-00036-00022648-00023200": "greens in the scenes but i'm using that blue as a background but the local color of the flowers", "iLBBguflz90-00037-00023200-00023656": "they're purple okay they're kind of a bluish purple and so i'm using the color", "iLBBguflz90-00038-00023656-00024208": "that's already there now i do have a lot of different underpainting strategies that i use", "iLBBguflz90-00039-00024208-00024728": "that i will be describing each one of these i use a little bit of a different underpainting", "iLBBguflz90-00040-00024816-00025552": "concept or technique and i will be describing each one as i paint another question i get often", "iLBBguflz90-00041-00025552-00026248": "is about the rules of underpainting as if there are hard and fast rules there are some general", "iLBBguflz90-00042-00026248-00026824": "guidelines but really you can get creative and the underpainting typically just sets the mood", "iLBBguflz90-00043-00026824-00027248": "so i'll definitely talk about that with each painting oh here's a behind-the-scenes setup", "iLBBguflz90-00044-00027248-00027952": "i decided oh ignore my face to put on my raspberry beret i recently bought and uh you know one of the", "iLBBguflz90-00045-00027952-00028504": "advantages of working from your home studio is you can just get up and put on whatever you want or", "iLBBguflz90-00046-00028504-00029136": "not put on whatever you want work in your pajamas oh my goodness i know i'm such a nut i have found", "iLBBguflz90-00047-00029136-00029552": "there's freedom though and not worrying so much about what you look like it's really a blessing", "iLBBguflz90-00048-00029552-00030208": "all right so i'm adding some pastels notice how neutral this pastel is this is a terry ludwig", "iLBBguflz90-00049-00030208-00030895": "pastel i believe it's part of the umber no no umber shadows and shades or shades of nature", "iLBBguflz90-00050-00030895-00031464": "set one of those and this is another neutral i think from that set i wanted to get in some", "iLBBguflz90-00051-00031464-00032288": "nice neutrals in those background grasses things in the distance get lighter and less punchy in", "iLBBguflz90-00052-00032288-00032816": "color they're not as bold so that's why i just set that stage right there with some neutrality", "iLBBguflz90-00053-00032816-00033480": "back there also too in the second in this video the second little painting i'm going to show", "iLBBguflz90-00054-00033480-00034152": "you all of the pastels that i choose now the re one of the reasons i'm showing two paintings now", "iLBBguflz90-00055-00034152-00034832": "in this particular video is because this one just like the one before i had some missed footage", "iLBBguflz90-00056-00034984-00035464": "you still can paint along my patrons on my patreon page by the way you guys are submitting", "iLBBguflz90-00057-00035464-00036128": "some beautiful work to the homework album many of my patrons on my patreon page are participating", "iLBBguflz90-00058-00036128-00036744": "in this series and turning their homework in and they're doing such a great job and they were able", "iLBBguflz90-00059-00036744-00037144": "to create the last painting even though there was some missed footage like this one but the the", "iLBBguflz90-00060-00037144-00037768": "second one in this video you're gonna see the full painting in real time and for this painting you", "iLBBguflz90-00061-00037768-00038384": "really see most of the footage you can absolutely recreate this painting with what i'm providing now", "iLBBguflz90-00062-00038384-00039016": "i've turned the pastel on its side also too there's different mark making possibilities", "iLBBguflz90-00063-00039016-00039656": "that we have with soft pastels i do have a video on i think it's 12 different ways to do", "iLBBguflz90-00064-00039656-00040088": "mark making with pastels something like that that was a pretty popular little video because i think", "iLBBguflz90-00065-00040088-00040728": "often we don't think about the different marks we can make to give different gesture and energy", "iLBBguflz90-00066-00040728-00041288": "and coverage and obviously when you turn your pastel on the side like this you cover more area", "iLBBguflz90-00067-00041288-00042008": "and now i'm switching to a cooler green can you tell this is cooler now what would make a color or", "iLBBguflz90-00068-00042008-00042760": "a green cooler versus a warmer green it's further away from yellow okay it has more blue in it so", "iLBBguflz90-00069-00042760-00043456": "and cooler colors typically are in the shadowy areas i always say think of it like this if you", "iLBBguflz90-00070-00043456-00044064": "get in the shade of a treat don't you get cooler so colors get cooler as well all right i'm adding", "iLBBguflz90-00071-00044064-00044624": "a little bit of this dark i'm not sure if this is a just a dark blue or maybe it's not that terry", "iLBBguflz90-00072-00044624-00045136": "ludwig dark i don't think it's not quite that dark i mean it looks super dark here because value's", "iLBBguflz90-00073-00045136-00045520": "relative it's because it's the darkest thing on here i could i could put something else down", "iLBBguflz90-00074-00045520-00046088": "that's dark and it would um all of a sudden change that uh value so now i'm getting a little bit of", "iLBBguflz90-00075-00046088-00046736": "that warmer green what i'm doing again you can access this reference photo i'm not putting it up", "iLBBguflz90-00076-00046736-00047480": "here because it's not my photo but it's on a free copyright free photo reference site pmp-art.com", "iLBBguflz90-00077-00047552-00048248": "now i am blending with a shammy cloth i'm speeding this up because you can kind of get the idea a lot", "iLBBguflz90-00078-00048248-00048728": "of people talk about how pastel matte they have a hard time with it the surface that i'm working on", "iLBBguflz90-00079-00048728-00049184": "now you see that dark isn't that darker than the first one i put down i'm working on the flowers", "iLBBguflz90-00080-00049184-00049680": "now i'll come back to the discussion about pastel matte and working on it but uh what", "iLBBguflz90-00081-00049680-00050136": "i'm doing right now this is another terry ludwig some of my favorite brands by the way are terry", "iLBBguflz90-00082-00050136-00050928": "ludwig sennelier pastel and unison i i love unison and also mount vision they're some of the better", "iLBBguflz90-00083-00050984-00051616": "soft pastels and um they you know i like them all for their own reasons i don't i think", "iLBBguflz90-00084-00051616-00052152": "i'd have a hard time picking out my number one brand but getting good quality pastels", "iLBBguflz90-00085-00052224-00052624": "is definitely a must i mean i couldn't afford to start with them i started with", "iLBBguflz90-00086-00052624-00053224": "a set of rembrandts and rembrandts are a medium to harder pastel but they are less", "iLBBguflz90-00087-00053224-00053879": "expensive they're still artists great they're professional grade but you don't get that bold", "iLBBguflz90-00088-00053952-00054584": "fresh color the way you do with the more expensive brands so all right back to the pastel matte paper", "iLBBguflz90-00089-00054696-00055176": "i've had some comments from artists saying um they have a hard time with coverage", "iLBBguflz90-00090-00055176-00055800": "or with you know it it just takes a while for it to look like it's um not the white of the paper or", "iLBBguflz90-00091-00055800-00056416": "whatever color pastel matte you're working on it does come in other colors but my advice is to do", "iLBBguflz90-00092-00056416-00056952": "a blending strategy like i just did either with a chamois cloth shaving cloth works great on pastel", "iLBBguflz90-00093-00056952-00057479": "matte doesn't work on you art paper so much it's you are it's too gritty it catches the cloth but a", "iLBBguflz90-00094-00057479-00058048": "piece of pipe foam insulation works well like like you can get from a hardware store some people have", "iLBBguflz90-00095-00058048-00058552": "said those little packing peanuts um work well some people have said pool noodles like if you", "iLBBguflz90-00096-00058552-00059072": "live in a climate where you know kids are swimming all the time you can cut off a piece of their pool", "iLBBguflz90-00097-00059072-00059567": "noodle i don't think they'll mind and you can use it to blend with paper towels work well too", "iLBBguflz90-00098-00059567-00060264": "so there's multiple ways you can blend but i don't recommend over blending just kind of like what", "iLBBguflz90-00099-00060264-00060896": "i've done here you use it at the initial stages to get that coverage do you notice how much softer", "iLBBguflz90-00100-00060896-00061352": "it looks now that i blended so maybe that'll help some of you guys who say you're having a", "iLBBguflz90-00101-00061352-00061960": "hard time with the coverage on the pastel mat just go ahead and get in an underpainting of sorts and", "iLBBguflz90-00102-00061960-00062479": "and blend uh be careful like i did i know i'm kind of going backwards with what i did already but", "iLBBguflz90-00103-00062479-00063008": "uh i don't just take one shammy cloth and blend all over it if you went back and looked at it you", "iLBBguflz90-00104-00063008-00063672": "can see i turn it and i use new sections to blend areas so that i'm not contaminating the color i'm", "iLBBguflz90-00105-00063672-00064176": "getting mostly the green in but i'm being careful not to color cover all the purple and vice versa", "iLBBguflz90-00106-00064176-00064920": "so use it strategically now notice this purple i'm adding now it's a lighter value right and i'm", "iLBBguflz90-00107-00064920-00065600": "putting it on top of the darker value purple now why would i do that why wouldn't i just put this", "iLBBguflz90-00108-00065600-00066256": "lighter value down first if i did it would be very flat it would have nothing to rest upon the darker", "iLBBguflz90-00109-00066256-00067040": "value gives it contrast some color vibration and energy and it helps the lighter value to actually", "iLBBguflz90-00110-00067040-00067736": "show up more light values show up better in contrast to dark values so it's really going", "iLBBguflz90-00111-00067736-00068232": "to make your colors pop if you learn to use the strategy of kind of laying down a darker value", "iLBBguflz90-00112-00068232-00068616": "and gradually working up to your lighter values and i'm even going to get lighter than this right", "iLBBguflz90-00113-00068616-00069200": "now i'm just working on the purples but you'll see um in a little while i'll add some blues", "iLBBguflz90-00114-00069288-00069976": "often too while i'm on this note about the flowers often we see flowers that have that purplish", "iLBBguflz90-00115-00070128-00070664": "really vibrant pretty purple like these and sometimes our brain just says these are purple", "iLBBguflz90-00116-00070664-00071200": "flowers this is lavender this is a you know just a flower that's kind of like lavender and it's", "iLBBguflz90-00117-00071200-00071760": "purple and we forget to really analyze it and look at it and see that there's actually some blue like", "iLBBguflz90-00118-00071760-00072576": "a vibrant gorgeous blue that if you add that to it it's going to create so much more interest", "iLBBguflz90-00119-00072576-00073056": "and actually i think more realistic to what some of these flowers really look like so and", "iLBBguflz90-00120-00073056-00073720": "you know like i said about shadows too um colors cool off in the shadows so in this flower", "iLBBguflz90-00121-00073720-00074384": "there's going to be cooler tones purple's kind of a cooler tone already but blue is even cooler so", "iLBBguflz90-00122-00074440-00074888": "you know definitely some of those blues are going to make it really stand out", "iLBBguflz90-00123-00074888-00075456": "now in the background flowers i'm using three strategies to make them appear further away one", "iLBBguflz90-00124-00075456-00076080": "is size i'm making them smaller two is less detail and three is a lighter value notice i didn't put", "iLBBguflz90-00125-00076080-00076512": "that dark purple down back there now you're going to see where i missed the footage but", "iLBBguflz90-00126-00076512-00077032": "i'm going to explain to you what i've done i've added a few more cooler i'll talk about the b in", "iLBBguflz90-00127-00077032-00077464": "a minute i've added a few more cooler grasses in the background you see that and kind of work them", "iLBBguflz90-00128-00077464-00078032": "in and amongst the other grasses in the foreground now with the bees sorry i missed applying the bee", "iLBBguflz90-00129-00078088-00078664": "in the last video in this series i showed you how to make the little teeny weeny bees now this bee's", "iLBBguflz90-00130-00078664-00079056": "a little bigger because he's like right here on this flower and he's more of the focal point", "iLBBguflz90-00131-00079056-00079568": "so i put down my dark first just like i said with the flowers and then i gradually started working", "iLBBguflz90-00132-00079568-00080192": "my lighter values and with bees typically i will do a dark value kind of a reddish orange value", "iLBBguflz90-00133-00080192-00080960": "and then a golden color and now i think i'm going to use a new pastel spelt in you pastel", "iLBBguflz90-00134-00081032-00081480": "made by prismacolor and this is just to kind of reestablish the shape of the pastel i've been", "iLBBguflz90-00135-00081480-00081960": "doing pretty good with the big chunky pastels on such little subject matter but uh sometimes", "iLBBguflz90-00136-00081960-00082640": "i need something more precise like this so just working the b but also notice too on the flowers", "iLBBguflz90-00137-00082696-00083408": "remember how i mentioned the blues and i used some deeper blues and some lighter blues now what am i", "iLBBguflz90-00138-00083408-00083952": "doing here i'm getting his wings in you'd think i would just put in a light color for a wing but", "iLBBguflz90-00139-00083952-00084544": "i'm first putting down just like the same concept with the flowers not as dark but a darker color", "iLBBguflz90-00140-00084544-00085288": "than the shimmery white wing for the same reason to give the white something to rest upon and", "iLBBguflz90-00141-00085288-00086104": "it really does help give that feeling of reality you know when we do this it's more representative", "iLBBguflz90-00142-00086104-00086672": "of what they really look like so i'm just giving notice i'm not doing this hard i'm giving a really", "iLBBguflz90-00143-00086672-00087184": "really light touch and i'm trying not to make my marks linear it's better to make more of a", "iLBBguflz90-00144-00087248-00087984": "s a stroke um and gestural is always better if you can make a gesture mark there's just a knack", "iLBBguflz90-00145-00087984-00088416": "to that that really just comes with practice and experience and i'm still working at getting", "iLBBguflz90-00146-00088416-00088936": "better at having some nice gestural energy now i'm adding a little bit more of the lavenders", "iLBBguflz90-00147-00089040-00089496": "in different areas of the flowers establishing them a little bit more i don't want to give too", "iLBBguflz90-00148-00089496-00090072": "much detail everywhere because the expression i've been loving lately i can't remember which", "iLBBguflz90-00149-00090072-00090552": "artist i heard it from was uh if it's everywhere it's nowhere all right and think of that with", "iLBBguflz90-00150-00090552-00091144": "focal point if you have um you're doing a field of flowers and you have flowers first of all", "iLBBguflz90-00151-00091144-00091544": "everywhere or maybe they're all going in the same direction and they're all the same color they're", "iLBBguflz90-00152-00091544-00092040": "everywhere so really they're nowhere there's no focal point there's nothing that has any interest", "iLBBguflz90-00153-00092040-00092648": "because it's everywhere so it's the same idea with things like this obviously in this painting", "iLBBguflz90-00154-00092648-00093216": "the focal area is the bee and that flower in the foreground i also i'm not sure if i got rid of", "iLBBguflz90-00155-00093216-00093816": "that one flower i was working on on the bottom left there another focal strategy is keeping", "iLBBguflz90-00156-00093816-00094336": "your viewers eye within the painting don't give them an exit like a flower leading out of the", "iLBBguflz90-00157-00094336-00094984": "painting or too much detail on the perimeters aha i was right i decided that even though the", "iLBBguflz90-00158-00094984-00095408": "flower was in the reference image it was not a good compositional element so what am i doing", "iLBBguflz90-00159-00095408-00095960": "here this is a stiff bristle brush i don't even think i use it for painting it came in a cheap set", "iLBBguflz90-00160-00095960-00096520": "of brushes but it's so stiff it's easy to use it all i'm doing is brushing off some of the layers", "iLBBguflz90-00161-00096520-00097120": "of pastel this is an excellent way to re-establish some of your grit it also kind of blends things", "iLBBguflz90-00162-00097120-00097928": "so i i kind of blended in that flower so that it's not creating an exit point for the viewer's eye", "iLBBguflz90-00163-00098000-00098464": "again you want soft edges around the perimeter of your painting to keep the viewer's eye", "iLBBguflz90-00164-00098464-00099024": "where you want it to go and i'm using this to my advantage now because i'm going to go ahead", "iLBBguflz90-00165-00099024-00099728": "and make the stems and talk about gestural marks that's a good place to do this is with stems is to", "iLBBguflz90-00166-00099816-00100336": "vary your pressure and make your stroke energetic now what i'm doing here is adding", "iLBBguflz90-00167-00100336-00100744": "a little bit of a highlight this is really hard on a little two and a half by two and a half", "iLBBguflz90-00168-00100744-00101256": "inch painting with these big chunky pastels but it's like i've been saying in the previous videos", "iLBBguflz90-00169-00101256-00101688": "you learn to feel your way often when you're painting with pastels not just when you're", "iLBBguflz90-00170-00101688-00102208": "painting on small pastels paintings like this you're feeling where the pastel is", "iLBBguflz90-00171-00102208-00102720": "as much as you are seeing it sometimes you can't even see it as in my case but i usually do a", "iLBBguflz90-00172-00102720-00103383": "little test mark um it sounds laborious maybe but the more you do it um the easier it gets you know", "iLBBguflz90-00173-00103383-00103728": "it's kind of like i like to think of it like riding a bike at first you had to think about", "iLBBguflz90-00174-00103728-00104080": "balancing you had to think about the pedals you had to think about the steering wheel and you're", "iLBBguflz90-00175-00104080-00104640": "just like scared and it's a lot to think of and then later you get on a bike and you're just fine", "iLBBguflz90-00176-00104640-00105111": "so this all comes with practice determination and having fun all right here's the little bee", "iLBBguflz90-00177-00105176-00105735": "i thought this little guy was so cute and patrons too please remember to submit your homework if you", "iLBBguflz90-00178-00105735-00106400": "um decide to follow along with this painting all right now we are moving on to the fourth painting", "iLBBguflz90-00179-00106400-00106992": "i'm back on pmp-art once again i'll have the links to these photos in the description of this video", "iLBBguflz90-00180-00106992-00107480": "all you have to do is pull it up click the link on another device and you can paint from it you know", "iLBBguflz90-00181-00107480-00108088": "real easy and what's the first thing we begin with in these nine paintings anyway with watercolor", "iLBBguflz90-00182-00108088-00108559": "and also too remember how i mentioned i would use some different underpainting strategies if", "iLBBguflz90-00183-00108559-00109216": "you remember from seeing the photo in that little portion of the video just a minute ago it was some", "iLBBguflz90-00184-00109216-00110048": "white flowers green grasses and really the sky was very white um so with this painting i'm doing", "iLBBguflz90-00185-00110048-00110735": "more of what's called a warm underpainting the local colors were more like whites and greens and", "iLBBguflz90-00186-00110792-00111280": "really not a lot of color variety i liked the values and the painting though so i'm going to", "iLBBguflz90-00187-00111280-00111856": "kind of make it my own change the colors up a bit but i'm beginning with a warm underpainting", "iLBBguflz90-00188-00111856-00112448": "so i'll be using a lot of colors that are not really on the cooler side of the color wheel", "iLBBguflz90-00189-00112448-00113208": "perhaps with exception to this purple is probably the coolest in the colors that i use for the under", "iLBBguflz90-00190-00113208-00113648": "painting but the rest are going to be very warm i'm not using any blues or greens in other words", "iLBBguflz90-00191-00113648-00114328": "okay well maybe that's a little bluish purple but um the reason for this it's typically called a", "iLBBguflz90-00192-00114328-00115032": "complementary underpainting and complement is not like uh you compliment your friend with the", "iLBBguflz90-00193-00115032-00115896": "c-o-m-p-l-i it's c-o-m-p-l-e entry and the reason it's called complementary is because a", "iLBBguflz90-00194-00115896-00116416": "complementary color is a color that's opposite on the color wheel to the color that you're", "iLBBguflz90-00195-00116416-00116944": "trying to paint or looking at and so what are the colors in the local color of the reference image", "iLBBguflz90-00196-00116944-00117496": "they're greens they're kind of greens and blues and and you know the whites obviously so the color", "iLBBguflz90-00197-00117496-00118144": "opposite on the color wheel to greens and blues is more oranges and reds so i'm using the pink", "iLBBguflz90-00198-00118144-00118792": "the purple is like the distant trees and the reds are and oranges are the foreground which", "iLBBguflz90-00199-00118792-00119440": "works well because foreground colors typically get warmer in value anyway and it's also a great", "iLBBguflz90-00200-00119440-00119856": "idea to put down warm colors because i like the way artist karen margulis puts it she calls it", "iLBBguflz90-00201-00119856-00120208": "putting down the dirt you know before you have grasses you gotta have dirt and dirts usually", "iLBBguflz90-00202-00120208-00120768": "kind of orange or you know a warmer color so it's a good idea and it makes for a nice underpainting", "iLBBguflz90-00203-00120768-00121200": "but you don't always have to do a complimentary underpainting all right this set i'm using is the", "iLBBguflz90-00204-00121200-00121935": "sennelier 120 half stick i always recommend buying half sticks when you can because you", "iLBBguflz90-00205-00121935-00122840": "get double the color for your money and it is um called the paris 120 half stick set makes me want", "iLBBguflz90-00206-00122840-00123464": "to do a painting of something in paris i haven't done that yet but i've been using this set since i", "iLBBguflz90-00207-00123520-00124096": "purchased it uh just prior to leaving to go pretty much rescue my mother-in-law i've been mentioning", "iLBBguflz90-00208-00124096-00124704": "this in the past few videos um she is living with us now we went to get her mississippi where", "iLBBguflz90-00209-00124704-00125248": "she lived and she's on hospice care with terminal cancer and i got this set before going and i took", "iLBBguflz90-00210-00125248-00125983": "it with me and we got snowed in and so um with the being snowed in i actually got a decent amount of", "iLBBguflz90-00211-00125983-00126456": "painting time you know of course taking care of her as well so i got to kind of break the set in", "iLBBguflz90-00212-00126456-00127152": "and i love it it's really awesome i recommend this one if you can spare the extra money or the unison", "iLBBguflz90-00213-00127152-00127664": "120 half stick set i just love it now let's talk about these colors here to the right i have my", "iLBBguflz90-00214-00127664-00128440": "darker values a combination of some dark greens and a really dark kind of bluish green and some", "iLBBguflz90-00215-00128440-00129056": "cooler dark greens on the left i've got more of my blues with a little more color the lighter", "iLBBguflz90-00216-00129056-00129432": "colors in that band in the middle are going to be my flowers notice they're not all white", "iLBBguflz90-00217-00129535-00129880": "i'm actually going to give a little more variety and then my warm greens for the grasses and a", "iLBBguflz90-00218-00129880-00130592": "little neutral up there to the top right and i think i do add a few other pastels i grab a few", "iLBBguflz90-00219-00130592-00131376": "um as i work but that was a good start now same as before i'm just kind of sometimes i work with my", "iLBBguflz90-00220-00131376-00131984": "right hand and oh look at all those age spots dang why do we have to see ourselves get old like this", "iLBBguflz90-00221-00131984-00132768": "i'm fine with it as long as i don't see myself but um anyway so i'm working in the darker colors", "iLBBguflz90-00222-00132768-00133184": "in the trees i talk all the time about the fact that things that are vertical in a landscape are", "iLBBguflz90-00223-00133184-00133608": "darker in value because the sun's coming from the top and it has like shadows on the sides of", "iLBBguflz90-00224-00133608-00134400": "the trees so this is called like scumbling a super light touch often we are so heavy-handed and i'm", "iLBBguflz90-00225-00134504-00135032": "talking to myself because i've had that habit um in the past too i still try to get better at", "iLBBguflz90-00226-00135032-00135600": "it now once again using this little shammy cloth it's going to push those trees back", "iLBBguflz90-00227-00135600-00135992": "it's going to cover some of that blank space of the paper i want you to notice something", "iLBBguflz90-00228-00135992-00136344": "else too again back to the question some people have about why do you put an underpainting down", "iLBBguflz90-00229-00136416-00137080": "the pink of the paper even though i just blended these trees really does influence the color of the", "iLBBguflz90-00230-00137080-00137528": "trees now i'm grabbing sometimes i use the chamois cloth or pipe foam insulation to use almost like", "iLBBguflz90-00231-00137528-00138088": "a paint brush i get some of that dark that i have on it and i use it to create a darker value in the", "iLBBguflz90-00232-00138088-00138552": "foreground because i know the grasses are going to be deeper grasses and things in the foreground are", "iLBBguflz90-00233-00138552-00138960": "typically darker anyway all right so i'm playing around with some of these blues this is actually", "iLBBguflz90-00234-00138960-00139560": "one of the lighter blues from the ones that i said where the sky the three sky colors now here's an", "iLBBguflz90-00235-00139560-00140248": "interesting thing about sky holes those are the little holes like i'm starting to do there that", "iLBBguflz90-00236-00140320-00140808": "kind of make the spaces and the branches and the holes of the trees and this is called", "iLBBguflz90-00237-00140808-00141280": "negative painting instead of painting the branches we're making kind of a big shape", "iLBBguflz90-00238-00141280-00141864": "with the trees and we're carving in the branches so oh actually that was a darker blue now i've", "iLBBguflz90-00239-00141864-00142296": "got a little bit of the light blue that i'm just putting in a couple of areas um", "iLBBguflz90-00240-00142296-00142784": "i would say more towards the horizon but kind of at the tips of the trees to create a focal", "iLBBguflz90-00241-00142784-00143352": "point with the lighter value but i'm going to add some darker blue after i add this green", "iLBBguflz90-00242-00143448-00143984": "up in the top part of the sky there you'll see me do that in a minute now to give some interest here", "iLBBguflz90-00243-00143984-00144416": "i know these trees are green and not that dark color that i had down i got the dark down just to", "iLBBguflz90-00244-00144416-00144968": "get the basic value and i'm scumbling once again i think i said that word and to describe what it is", "iLBBguflz90-00245-00144968-00145912": "it's kind of just making random marks very lightly in not haphazard places kind of strategic places", "iLBBguflz90-00246-00145912-00146512": "i'm always imagining where the light is coming from as i'm painting and quite often the outer", "iLBBguflz90-00247-00146512-00146968": "almost always the outer leaves and things on the tree are going to get a little bit of a lighter", "iLBBguflz90-00248-00146968-00147424": "value and a warmer value because the sun's getting it more the things that are deeper in the trees", "iLBBguflz90-00249-00147424-00147880": "are going to be a little darker and a little cooler so now i'm just getting an idea of maybe", "iLBBguflz90-00250-00147880-00148632": "like some branches down in there and again this is a really really little painting and i've mentioned", "iLBBguflz90-00251-00148632-00149248": "before i like little painting because it forces you to be loose you can't really get too fussy and", "iLBBguflz90-00252-00149248-00150072": "detailed so blending the dark in again i did want some deeper dark values down at the roots or the", "iLBBguflz90-00253-00150072-00150664": "base of those trees there you see how that just gave it some substance and some three-dimensional", "iLBBguflz90-00254-00150728-00151376": "feel to it so now this is a cooler green those were all the dark greens you saw at the beginning", "iLBBguflz90-00255-00151376-00151944": "that were kind of on the right hand side i'm getting some of these cooler greens down deeper", "iLBBguflz90-00256-00151944-00152376": "not covering up all of the dark i put in but that's what's going to happen to these greens", "iLBBguflz90-00257-00152376-00153032": "with some of the leaves that are you know behind the ones that are in sunlight now i'm using that", "iLBBguflz90-00258-00153032-00153728": "neutral color you see how it's a little bit of a teal color but it's not a bright punchy teal", "iLBBguflz90-00259-00153728-00154352": "it's neutral what this is going to do i'm creating a band of trees i love to create depth in my", "iLBBguflz90-00260-00154352-00154960": "paintings even if i don't see it in the photograph i'll push the viewer's eye back by two strategies", "iLBBguflz90-00261-00154960-00155584": "cooling off the color and lightening the value and also too even though sometimes i use punchy colors", "iLBBguflz90-00262-00155664-00156240": "things in the distance usually get a little more neutral in color so often it's a good idea or", "iLBBguflz90-00263-00156240-00156688": "strategy to neutralize the color in the distance so you see how now it looks like a couple of", "iLBBguflz90-00264-00156688-00157584": "different banks of trees once further away using this same paris 120 half stick set kind of a deep", "iLBBguflz90-00265-00157640-00158032": "greenish blue i love this color just for some of these deeper", "iLBBguflz90-00266-00158104-00158592": "grasses and you see already how it's starting to take shape with just these few colors that", "iLBBguflz90-00267-00158592-00159144": "i've used we're getting the feeling of a field and those trees have some energy and once again", "iLBBguflz90-00268-00159144-00159696": "blending again i don't blend a lot in the later stages but it really does set the mood when you", "iLBBguflz90-00269-00159696-00160304": "do it early on now here finally adding some warmth here these are the warmer grasses i'm not drawing", "iLBBguflz90-00270-00160304-00161000": "blades of grasses yet i'm just giving suggestions of some maybe some taller grasses and um almost", "iLBBguflz90-00271-00161000-00161744": "like um just doing a big kind of shape where i can later add in some more individual grass", "iLBBguflz90-00272-00161744-00162224": "i did add a little bit of a focal point there with one of those tall grasses reaching up there", "iLBBguflz90-00273-00162224-00162896": "so again still not a lot of detail yet notice that and actually with this painting like i say", "iLBBguflz90-00274-00162896-00163448": "in a lot of my videos when i do a voiceover like i'm doing now i get the advantage of seeing the", "iLBBguflz90-00275-00163448-00164008": "different stages of my painting and quite often i'm like man i really liked it when it was uh", "iLBBguflz90-00276-00164008-00164600": "halfway done sometimes you know three quarters of the way but all right now some little highlights", "iLBBguflz90-00277-00164600-00165088": "of grasses just like with grass as you see in real life usually the highlights are going to be on the", "iLBBguflz90-00278-00165088-00165536": "top parts of the grasses they're not going to be down deep and they're not going to be as warm in", "iLBBguflz90-00279-00165536-00166080": "color down deep in the grasses and you know even though this is just a little painting i'd love", "iLBBguflz90-00280-00166080-00166672": "to give a lot of commentary because i think you can just learn a lot from listening uh watching", "iLBBguflz90-00281-00166672-00167184": "of course but listening to the commentary and even though i know there's a lot of artists who", "iLBBguflz90-00282-00167184-00167776": "just provide the video footage and then they'll provide the commentary maybe on their patreon page", "iLBBguflz90-00283-00167872-00168432": "i like to still provide the free commentary here on monet cafe because i know there are a lot of", "iLBBguflz90-00284-00168432-00169240": "people with limited means that are trying to learn this and i always remember how hard it was for me", "iLBBguflz90-00285-00169240-00169904": "i was a single mom unexpectedly with three boys i was trying to raise starting a new job and things", "iLBBguflz90-00286-00169904-00170488": "were challenging and art was my sanctuary it was just what i was trying to figure out again and", "iLBBguflz90-00287-00170488-00171296": "reclaim for myself to keep my sanity and back then in the good old days um things were not as easy to", "iLBBguflz90-00288-00171296-00171920": "find as they are now i mean i'm not that old but uh i'm how old am i i am 56 right now i'll be 57", "iLBBguflz90-00289-00171920-00172536": "in june but um anyway it was just harder youtube didn't it was around but it wasn't what it is now", "iLBBguflz90-00290-00172536-00173112": "and um so i had a hard time finding things and that is the beginning that's this back story to", "iLBBguflz90-00291-00173112-00173696": "monet cafe i was like i'm going to start sharing my journey and the things that i learned so that's", "iLBBguflz90-00292-00173696-00174216": "how it came about all right look at these purples this is kind of a magenta deep magenta purple", "iLBBguflz90-00293-00174216-00174720": "added some in those grasses added a little bit in the trees because once again we have some", "iLBBguflz90-00294-00174720-00175232": "pretty purple sometimes going on in the shadows now i was a little hesitant about this color oh", "iLBBguflz90-00295-00175232-00175920": "see yeah i was it was too bright it just demanded too much attention so even though i like punchy", "iLBBguflz90-00296-00175920-00176448": "color um that's my i don't know if that's my word i always use that word somebody said something one", "iLBBguflz90-00297-00176448-00177304": "time about not being the right word but whatever but um bright color bold color but sometimes a", "iLBBguflz90-00298-00177304-00177744": "mood or a setting requires something more neutral now also see how i put that a little further back", "iLBBguflz90-00299-00177864-00178400": "where that tree is the smaller tree that is giving the indication of a field that's further", "iLBBguflz90-00300-00178400-00178792": "away you're not going to see much of it because the grasses are tall but you get a little glimpse", "iLBBguflz90-00301-00178792-00179464": "of it and once again that pushes the perspective back you're creating i always love to say this", "iLBBguflz90-00302-00179464-00180080": "you're creating a three-dimensional world on a two-dimensional surface it's like magic and it's", "iLBBguflz90-00303-00180080-00180600": "just some rules some tricks i don't usually like the word tricks but it's an illusion", "iLBBguflz90-00304-00180600-00181112": "and i think that's what fascinates me about art first i'm a color freak i just go to color like", "iLBBguflz90-00305-00181112-00181648": "uh what are those birds is it a magpie or a bird that goes to like bright shiny things and oh my", "iLBBguflz90-00306-00181648-00182160": "gosh i just love it now here's where i said back a while ago i was going to add some darker blues", "iLBBguflz90-00307-00182160-00182760": "now also too with sky holes when you get down and you're adding those negative spaces in the trees", "iLBBguflz90-00308-00182760-00183288": "um don't use the lightest light always go a little bit of they look kind of weird right", "iLBBguflz90-00309-00183288-00184024": "now but they always look too much like popcorn if you put it deeper in the trees and the reason is", "iLBBguflz90-00310-00184024-00184528": "because the tree branches act like a filter if you ever notice a screen on a porch they", "iLBBguflz90-00311-00184528-00185072": "have little holes in them too but if the sun is shining behind them they don't look as bright as", "iLBBguflz90-00312-00185072-00185528": "if there was no screen it's it's a filter so it's going to make values a little darker i did add a", "iLBBguflz90-00313-00185528-00186200": "little bit of a a brighter value green i apologize i think i forgot to turn my light on in this part", "iLBBguflz90-00314-00186304-00186832": "but i think you can still get the same idea okay now in my reference image all", "iLBBguflz90-00315-00186832-00187368": "the flowers were white even if and i don't keep them all super white but even if i did", "iLBBguflz90-00316-00187368-00188088": "i would still go a shade darker in value for the deeper flowers the reason is because again they're", "iLBBguflz90-00317-00188088-00188520": "in shadow they're going to be buried i'm going to bury these with some grasses if i made them all", "iLBBguflz90-00318-00188520-00189056": "white it would two things would happen it wouldn't look realistic because that's not what all", "iLBBguflz90-00319-00189056-00189728": "flowers white flowers do and see how i added some variety with that blue and also it would detract", "iLBBguflz90-00320-00189728-00190248": "from your focal point my focal point is going to be some of the white flowers that are on the tops", "iLBBguflz90-00321-00190248-00190880": "so these are the supporting actors and actresses and they're just pulling the viewers saying hey", "iLBBguflz90-00322-00190880-00191464": "look at the star that's going to be up there in the in the upper grasses so if that's a little", "iLBBguflz90-00323-00191536-00191952": "visual picture that helps you remember that all right let's get some of these", "iLBBguflz90-00324-00191952-00192680": "flowers in now here is a lesson i'm always trying to learn is what makes a", "iLBBguflz90-00325-00192968-00193920": "lyrical beautiful gestural floral arrangement in a field and i always try to think of the", "iLBBguflz90-00326-00193920-00194752": "way flowers look when they're like blowing in the wind they're random and musical at the same time", "iLBBguflz90-00327-00194752-00195376": "um if anybody's a musician have you ever heard um of the term dissonance it's like a note that's a", "iLBBguflz90-00328-00195376-00195952": "little bit off but for some reason it makes the song so much more interesting um i think that's", "iLBBguflz90-00329-00195952-00196568": "one of the reasons one of my favorite songs is moonlight sonata it's just got a some sections in", "iLBBguflz90-00330-00196568-00197032": "it that i'm just like oh i just get overwhelmed it's so beautiful and there's something that", "iLBBguflz90-00331-00197032-00197624": "is just a little bit call it a focal point um but it's a little off and what i mean by", "iLBBguflz90-00332-00197624-00198344": "off is not like way off but if we have all of our flowers just super patterned and mine are a little", "iLBBguflz90-00333-00198344-00198968": "patterned right now too um it's not as interesting as if there's one that's just kind of we sticking", "iLBBguflz90-00334-00198968-00199408": "up somewhere and it's way more interesting so i'm always kind of trying to work on that", "iLBBguflz90-00335-00199408-00199888": "and get better at that now these little dark areas are i'm thinking they're going to be like", "iLBBguflz90-00336-00200040-00200560": "these seed pods someone recently corrected me i called them something of buds of a flower and", "iLBBguflz90-00337-00200560-00201088": "actually in the reference image they were the seed pods where the the but the flower actually dies", "iLBBguflz90-00338-00201088-00201720": "and it um creates the seed pod um so and they're usually darker now i'm just working the sky in a", "iLBBguflz90-00339-00201720-00202272": "little bit here but also those little dark marks too if you saw the last video i showed you how", "iLBBguflz90-00340-00202272-00202680": "to make those cute little bees i decided in all of these i was going to add some bees i don't", "iLBBguflz90-00341-00202680-00203208": "know why i just got on a b kick so um the little black marks are probably going to be a combination", "iLBBguflz90-00342-00203208-00203744": "of seed pods and bees i need a little more dark in that sky and a little more color so it wasn't", "iLBBguflz90-00343-00203744-00204264": "that hard to do it you know you just kind of put some in there and i just lightly uh blend", "iLBBguflz90-00344-00204264-00204967": "it in and i got a little bit of darker up there in the sky create a little bit of a halo effect", "iLBBguflz90-00345-00205071-00205704": "an ellipse effect to keep the viewer's eye once again in your painting we don't want to give", "iLBBguflz90-00346-00205704-00206248": "the viewer some easy excuse to exit the painting like a flower pointing right out of the painting", "iLBBguflz90-00347-00206248-00206871": "or a line of a building going straight up or a branch of a tree just pointing right out of the", "iLBBguflz90-00348-00206871-00207656": "painting so we want to just beautifully arrange things in a way where the viewer just stays right", "iLBBguflz90-00349-00207656-00208096": "where you want them to stay all right i've added a few more little sky holes trying to make things", "iLBBguflz90-00350-00208096-00208567": "interesting see how that dark was needed for scot not dark but you know it's not the whitest white", "iLBBguflz90-00351-00208567-00209040": "back there in the back once again the little filter effect um so i'm getting close to done", "iLBBguflz90-00352-00209040-00209632": "now here comes the lights this i decided to make a little warmth to it all right it's at the top", "iLBBguflz90-00353-00209632-00210200": "part it's going to get a little more warmth so this is a of course one of the same senneliers", "iLBBguflz90-00354-00210200-00210967": "senneliers are like butter even after you've applied a few layers you can just really still", "iLBBguflz90-00355-00210967-00211519": "get that color that sticks and that's bright and beautiful i'm being careful trying to be careful", "iLBBguflz90-00356-00211519-00212152": "not to give too much again if it's everywhere it's nowhere so it's getting close i'm getting close", "iLBBguflz90-00357-00212152-00212832": "and i think at this point i add maybe a few more warm grasses a few more little random flowers yeah", "iLBBguflz90-00358-00212832-00213496": "here's a little bit more warmth and i'm also learning i've learned over the years to limit", "iLBBguflz90-00359-00213496-00214144": "my grasses and vary my grasses you don't want them all just reaching up in the same direction", "iLBBguflz90-00360-00214200-00214671": "and you can use focal strategies with grasses too to keep your viewers eye where you want it", "iLBBguflz90-00361-00214671-00215096": "uh all right a few more little random flowers and then we're gonna get to the bees", "iLBBguflz90-00362-00215232-00215760": "now i've zoomed in hopefully so you can see this and i will admit some of these bees and", "iLBBguflz90-00363-00215760-00216240": "these paintings were so teeny they were hard but take a look at the video right before this", "iLBBguflz90-00364-00216240-00216776": "one it's painting number two in this series and i will have a link to painting number one", "iLBBguflz90-00365-00216776-00217264": "and number two in this nine painting series in the description of the video in all the videos", "iLBBguflz90-00366-00217264-00217632": "you'll have the previous links to see the other ones i'll put them all in a playlist how about", "iLBBguflz90-00367-00217632-00218136": "that that's a good idea um so in the previous video i show you close up a little bit more what", "iLBBguflz90-00368-00218136-00218519": "we're going to do with the bees is we're going to make two little marks you can make two or three", "iLBBguflz90-00369-00218519-00219096": "marks but i find when they're this little you see this pastel had some little random um sides to it", "iLBBguflz90-00370-00219096-00219776": "they're still fairly new but we're going to put a little golden kind of a mark or or orangey kind", "iLBBguflz90-00371-00219776-00220496": "of a mark on the back to the section behind the head and then we're going to add some little wings", "iLBBguflz90-00372-00220496-00221128": "like i did you know in the first painting a darker value blue and then a lighter value white or", "iLBBguflz90-00373-00221223-00221736": "lighter value light blue like this one it's so hard with these little wings but um just on the", "iLBBguflz90-00374-00221736-00222128": "wings i admit they're kind of hard this one i think one of them came out a little better than", "iLBBguflz90-00375-00222128-00222632": "the other ones but so i hope you guys enjoyed this here's the final painting also too if you decide", "iLBBguflz90-00376-00222632-00223048": "to paint from this and you're not a patron of mine and you share it on instagram make sure you", "iLBBguflz90-00377-00223048-00223592": "tag me at susan jenkins artist i love to see what you do patrons this is your homework assignment", "iLBBguflz90-00378-00223592-00224184": "and have fun alright guys please subscribe if you haven't and as always happy painting"}}]