tokens: A total of 229 patients with UCDs were enrolled in this study : 73 males and 53 females with ornithine transcarbamylase deficiency ( OTCD ) , 33 patients with carbamoylphosphate synthetase 1 deficiency , 48 with argininosuccinate synthetase deficiency , 14 with argininosuccinate lyase deficiency , and 8 with arginase deficiency .