tokens: Evaluating the molecular properties of the genes undergoing intragenic mutations or copy number variations ( CNVs ) along with prevalence of craniosynostosis in different conditions and animal models if available , we made an attempt to define two distinct groups of unusual syndromic craniosynostosis , which can reflect direct effects of emerging new candidate genes with roles in suture homeostasis or a non - specific phenotypic manifestation of pleiotropic genes , respectively .