tokens: In addition , CLCN1 gene was sequenced by NGS ( Next Generation Sequencing Method ) and possible causes of inherited thrombophilia risk including MTHFR ( A1298C ) , Factor V Leiden ( G1691A ) , Factor II ( G20210A ) , MTHFR ( C677 T ) , Factor V Cambridge ( G1091C ) , plasminogen activator inhibitor 1 ( PAI-1 ) 4G/5 G , APOE , APOB , ITGB , ACE ( ins / del ) , FVHR2 and FGB gene alterations were evaluated .