tokens: PIDs were varied : immunoglobulin deficits ( n = 30 ) , chronic granulomatous disease ( n = 3 ) , hyper - IgM syndrome ( n = 3 ) , hereditary complete C4 deficiency ( n = 1 ) , leucocyte adhesion deficiency type 1 ( n = 1 ) , hyper - IgE syndrome ( n = 1 ) , and Chediak - Higashi syndrome ( n = 1 ) .