tokens: Overall , five main themes emerge as critical in advancing research : ( 1 ) monitoring of the occurrence of CPO ( capacity building ) ; ( 2 ) detailed phenotyping of the severity ( biology ) ; ( 3 ) understanding of the genetic and environmental risk factors ( primary prevention ) ; ( 4 ) access to early detection and multidisciplinary treatment ( clinical services ) ; and ( 5 ) understanding predictors of recurrence and possible interventions among families with a child with CPO ( secondary prevention ) .