tokens: Antibiotic prophylaxis ( n = 34 ) , antipneumococcal vaccination ( n = 31 ) , and/or IgG infusion ( n = 19 ) , when instituted , had a beneficial impact on patients until the teenage years , with no seemingly detectable impact thereafter . IRAK-4 and MyD88 deficiencies predispose patients to recurrent life - threatening bacterial diseases , such as invasive pneumococcal disease in particular , in infancy and early childhood , with weak signs of inflammation .