text: No, developing bleach resistance is nigh impossible because that would literally require the microbe to develop a coat of metal, bleach can pretty much burn through anything organic. Also, the problem with antibiotic resistant bacteria is not that they are completely impervious to antibiotics (simply up the dose and they will still die), it's just that they evolve to be impervious enough so that we can't use the antibiotic on people anymore, as the dosage needed to kill the resistant bacteria will kill the human too. This is not a problem with bleach, considering no one will be drinking it to treat strep throat. So even if somehow bleach resistance starts developing, no problem, just pour on more bleach.