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0.405316 | cac81f7752d04e19961180890dc18a0c | ITC profile
of the HSA–GAL system. The sample cell was filled
with 20 μM HSA, while the syringe contained 500 μM GAL. | PMC9521020 | ao2c04004_0008.jpg |
0.479063 | e6e41a0196d941b881aadcdb130eacfa | Flow chart | PMC9521562 | 12879_2022_7743_Fig1_HTML.jpg |
0.397311 | e6069336883f458ba9bf40ef85136754 | Bacterial isolates in respiratory samples from late bacterial secondary infections. Seventy-one late bacterial secondary infections (excluding patients transferred from another institutions). MDR multidrug resistant bacteria; N = number of samples for each bacteria | PMC9521562 | 12879_2022_7743_Fig2_HTML.jpg |
0.4361 | 7cabea45d21a4548a46d1504183e4242 | Patients with secondary infection and steroids use | PMC9521562 | 12879_2022_7743_Fig3_HTML.jpg |
0.411019 | d2e3ce34e6394690bd8dc22593e46483 | PRISMA diagram. | PMC9521568 | fneur-13-964196-g0001.jpg |
0.391734 | e47ea082c09f4c6587497fe18c99fb83 | Comparison of the effect of home-based intervention and conventional therapy on UL function (A) standardized mean difference (SMD) immediately after the treatment. (B) Standardized mean difference (SMD) at follow-up. | PMC9521568 | fneur-13-964196-g0002.jpg |
0.393181 | 1b34293b0d0b494296d815b7bc0e86ea | Comparison of the effect of home-based intervention and conventional therapy on MAL outcomes (A) mean difference (MD) immediately after the treatment. (B) Mean difference (MD) at follow-up. | PMC9521568 | fneur-13-964196-g0003.jpg |
0.390093 | 40451e8d8db74125a765fbbd5f7faa6d | Comparison of the effect of technology-assisted home-based intervention and “no technology” intervention on UL function (A) standardized mean difference (SMD) immediately after treatment. (B) Standardized mean difference (SMD) at follow-up. | PMC9521568 | fneur-13-964196-g0004.jpg |
0.388616 | de82318870934a2489883497ed0dff26 | Comparison of the effect of the technology-assisted home-based intervention and “no technology” intervention on MAL outcomes immediately after treatment MAL-AOU and MAL-QOM. | PMC9521568 | fneur-13-964196-g0005.jpg |
0.390316 | 63e5842933724e279ac27120204fce47 | Comparison of the effect of home-based intervention and no treatment on UL function after the treatment. | PMC9521568 | fneur-13-964196-g0006.jpg |
0.409944 | 501a807fada143bca9e294846814ee8b | Exclusion criteria diagram | PMC9521855 | 11469_2022_920_Fig1_HTML.jpg |
0.466777 | cbe9f0c14536425da31734928fc32f8e | Time to first readmission curve | PMC9521855 | 11469_2022_920_Fig2_HTML.jpg |
0.421018 | 3dbc2d9798ae4dedb58f7785182111ba | Reimbursement trends from 2007–2021 | PMC9521869 | 10434_2022_12561_Fig1_HTML.jpg |
0.467123 | 62014a8541364abdaecd2b92e22b80e1 | Scoping review flow chart. | PMC9522276 | pone.0273819.g001.jpg |
0.435954 | 38f7b2ce86df44cba43cdd3e8b095c83 | Overview of ADHD association studies.Pediatric/adolescent studies: Age 19 years or less; adult studies: Age 19 years or greater. | PMC9522276 | pone.0273819.g002.jpg |
0.409073 | 870d0548f15c4080a33d0c2bbaffe693 | Overview of ASD association studies.Pediatric/adolescent studies: Age 19 years or less; adult studies: Age 19 years or greater. | PMC9522276 | pone.0273819.g003.jpg |
0.420113 | fcbd746aa24a461d876d3b4d998ee146 | Overview of biomarkers used in ADHD association studies. | PMC9522276 | pone.0273819.g004.jpg |
0.494419 | c0f4fe09fe7b4f909296e4a79509d95e | Overview of biomarkers used in ASD association studies. | PMC9522276 | pone.0273819.g005.jpg |
0.395571 | f69cbec6729745ff866f9a9266b0e1bc | The effect of HF/HS diet on body weight in Swiss mice and B6 mice.Experimental feeding was started at W0. Body weight was weekly monitored. Data are shown as mean ± SEM. Significant difference (P ≤ 0.05) between treatment groups within each strain per time point are indicated by an asterisk (*). | PMC9522283 | pone.0275379.g001.jpg |
0.428811 | ad7ffed567db4280b22bf7fa8ece2ca0 | The effect of HF/HS diet on total serum cholesterol concentrations in both Swiss (A) and B6 (B) mice. Data are shown as mean ± SEM. Significant differences (P ≤ 0.05) between HF/HS and control groups within each strain per time point are indicated by an asterisk (*). Tendencies (P < 0.1 and > 0.05) are indicated by a dollar sign ($). | PMC9522283 | pone.0275379.g002.jpg |
0.484378 | 27399510357a431d8880cf104a83ec6b | HF/HS diet effects on serum concentrations (pg/mL) of different cytokines in Swiss mice.GM-CSF (A), IFN-β (B), IL-1α (C), IFN-γ (D), MCP-1 (E), TNF-α (F), IL-17A (G), IL-23 (H), IL-10 (I), IL-6 (J), IL-27 (K), IL12p70 (L), IL-1β (M). Data are shown as mean ± SEM. Significant differences (P ≤ 0.05) between HF/HS and control groups per time point are indicated by an asterisk (*). Tendencies (P < 0.1 and > 0.05) are indicated by a dollar sign ($). | PMC9522283 | pone.0275379.g003.jpg |
0.403168 | fe1488ea5ab941bea96da3a87c804bd4 | HF/HS diet effects on transcription markers of oxidative stress (A-F), ER-stress (G, H), inflammation (I), mitochondrial stress (J, K) and protein folding (L) in Swiss OECs. Columns display mean ± SEM of fold changes relative to housekeeping genes. Significant changes (P ≤ 0.05) between HF/HS and control groups per time point are indicated with an asterisk (*). Tendencies (P < 0.1 and > 0.05) are indicated by a dollar sign ($). ND stands for ‘not detected’. | PMC9522283 | pone.0275379.g004.jpg |
0.41748 | f0d78073235649aa89ca8f8fee094e80 | HF/HS diet effects on transcription markers of oxidative stress (A-F), ER-stress (G, H), inflammation (I), mitochondrial stress (J, K) and protein folding (L) in B6 OECs. Columns display means ± SEM of fold changes relative to housekeeping genes. Significant changes (P ≤ 0.05) between HF/HS and control groups per time point are indicated with an asterisk (*). | PMC9522283 | pone.0275379.g005.jpg |
0.403513 | 921a36735fa941d4b233c661d6d3724e | Valeric Acid targets the HDACs. HDAC3 and 7 were predicted to be the potential targets of VA, respectively, by Swiss target prediction assay (A) and PPI network (B) | PMC9522682 | 12032_2022_1814_Fig1_HTML.jpg |
0.386348 | 651205a1e34841d2b25db6459d9763b8 | VA has been predicted to impact HDAC activity and prostate cancer. “Histone deacetylase activity (H3-K14 specific)” and “histone deacetylase activity” ranked at the first (P < 0.05) and 11th place (P > 0.05), respectively. Both of them have been predicted to be regulated by VA (A). The KEGG pathways analysis (B) displayed the potential diseases or pathways that might be affected by VA. The top predicted result is prostate cancer | PMC9522682 | 12032_2022_1814_Fig2_HTML.jpg |
0.455683 | 56e8b54c47da47f1b5297c276629d42d | VA suppresses the expression of HDAC3. In both PC-3 and DU145 cells, after 48-h treatment of VA, and the expression of HDAC3 was reduced significantly, compared with NC group (P < 0.05) (A–E). Meanwhile, in both PC-3 and DU145 cells, after 48-h treatment of VA, the expression of HDAC3 protein was reduced, compared with NC group (F) | PMC9522682 | 12032_2022_1814_Fig3_HTML.jpg |
0.489046 | a67e3b75c18f47eda2e1ecded54d566d | Effect of VA on proliferation of prostate cancer cell lines. VA has anti-proliferative effect on prostate cancer cells while being low toxic to normal cells and such effect could be reduced by HDAC3 gene knockout. The inhibition rates of PC‐3 in the presence of 100 μM VA ranged from 34.42 ± 5.9% to 56.08 ± 1.28% during 24 h to 96 h and displayed significantly higher inhibition rates when compared to the 50-μM VA group with the range from 16.52 ± 2.32% to 24.76 ± 2.32% (P < 0.001, from 24 to 96 h) (A). Similar trends have been displayed in DU145 (B). Moreover, for RWPE-1 and RWPE-2, the inhibition rates of 50 μM VA group were significantly lower when compared to 100 μM group, respectively (C and D). The relative HDAC3 expression was significantly decreased in HDAC3-KO group than none transfection group in both PC-3 and DU145 cell lines (E). The inhibition rates were significantly decreased in CAXII-KO group compared to both non-transfection group and none-KO group, at 24, 48, 72, and 96 h, respectively, in PC-3 and DU145 cell lines (F and G) | PMC9522682 | 12032_2022_1814_Fig4_HTML.jpg |
0.451516 | 7fd289cc34964dce82b344465fd04c21 | The representative 3D spheroid models of PC-3 (A) and DU145 (B) cells were treated by VA and NC, respectively. The cross-section area inhibition rates eventually climbed to 46.77 ± 19.62% and 48.07 ± 19.72% at 96 h for PC-3 and DU145 cells, respectively (C). The CASP3 SA (caspase-3 specific activity) has shown that VA evaluated the caspase-3 activity in both PC-3 and DU145 cells cultured in either 2D or 3D system, compared to respective NC (P < 0.05) (D). Relative expression of E2F1 and E2F3 in VA group was significantly lower that of NC, respectively (P < 0.001) (E, F), NC negative control | PMC9522682 | 12032_2022_1814_Fig5_HTML.jpg |
0.432721 | 2d1ea4e3c39e4f429c519810d62e054f | Effects of VA on PC-3 cell in vivo. Treatment of single VA, single CDDP, and VA + CDDP significantly reduced the tumor weight of prostate cancer-bearing mice (A). Tumor inhibition rate (TIR) VA + CDDP group was significantly higher than that in VA and CDDP group (P < 0.05), respectively B VA induced the cell apoptosis and arrested the cell cycle of PC-3 cells. Flow cytometry analysis found that either VA or CDDP can significantly increase the apoptosis rate compared to NC group (P < 0.05), respectively (C, E). Treatments significantly increased the proportion of G0/G1 phase cells and significantly decreased the proportion of S phase and G2/M cells (D, F) | PMC9522682 | 12032_2022_1814_Fig6_HTML.jpg |
0.436645 | 2a2752056a244a5db346e8386f569c15 | BMP2 is highly expressed in lung adenocarcinoma patients with lymph node metastasis. (A) The representative BMP2 immunohistochemistry (IHC) images in tissue samples from patients with and without lymph node metastasis. Slides were observed under 4 × and 40 × magnification. (B) BMP2 IHC was analyzed in samples derived from 94 patients with lung cancer. Significance was determined by Fisher’s exact test (p = 0.025). (C) Representative images of BMP2 and Vimentin immunofluorescence in samples derived from patients with and without lymph node metastasis. Slides were observed under 10 × magnification. (D) Quantitative analysis of fluorescence intensity of BMP2 and Vimentin. Analysis of fluorescence intensity was done at the original magnification using ImageJ software. At least three fields were quantified. | PMC9522928 | 41598_2022_20788_Fig1_HTML.jpg |
0.439353 | 96719a5db8864dfda89d5563f9c7264c | BMP2 is highly expressed in more invasive lung adenocarcinoma cells. (A) Migration ability was determined by seeding 5 × 104 cells in a migration chamber without Matrigel coating. Invasion ability was determined by seeding 1 × 105 cells in a migration chamber with Matrigel coating. After 24 h, the cells that successfully migrated through the filter were stained with Liu ‘s solution and counted. Slides were observed under 10 × magnification. (B) Quantitative data derived from (A). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted for each condition. (C) BMP2 and BMPR2 expression levels were determined by western blotting and qPCR. (D) The protein levels of epithelial and mesenchymal marker were analyzed by western blotting. The error bars represent SD, and the p-value was determined by Student’s t test (*p < 0.05; **p < 0.01; ***p < 0.001). | PMC9522928 | 41598_2022_20788_Fig2_HTML.jpg |
0.416551 | e37a45277fab424a8471c94c4f52821c | Inhibition of BMP2 reduces invasiveness and downregulates EMT in lung cancer cells. (A) The invasion and migration abilities were reduced in BMP2-depleted CL1-5 and AS2 cells. BMP2 expression was depleted by two specific shRNAs. shLacZ is the non-targeting control. Slides were observed under 10 × magnification. (B) Quantitative data derived from (A). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted and averaged for each cell line. (C) The protein levels of BMP2 and EMT marker were determined by western blotting in CL1-5 and AS2 cells. (D) Cell invasion and migration abilities were reduced in BMP2-depleted CL1-5 and AS2 cells. The expression of BMP2 was depleted by siRNA. A non-targeting siRNA was used as a control. Slides were observed under 10 × magnification. (E) Quantitative data derived from (D). Bar graphs represent the average number of migrated cells ± SD. At least three fields were measured in each cell line. (F) The expression levels of BMP2 and EMT markers were determined by western blotting. The p-value was determined by Student’s t test. (*p < 0.05, **p < 0.01, ***p < 0.001). | PMC9522928 | 41598_2022_20788_Fig3_HTML.jpg |
0.426594 | db4f588a5fce4595a2872d724e157f7a | Recombinant BMP2 treatment increases cell migration in human lung cancer cells. (A) The cell migration ability was determined by seeding cells in a migration chamber without Matrigel coating. Cells that migrated through the filter were stained with Liu ‘s solution and counted. Slides were observed under 10 × magnification. Cells were treated with 0, 5, 10 ng/ml recombinant human BMP2 (rhBMP2) in culture medium. (B) Quantitative data derived from (A). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted for each cell line following rhBMP2 treatment. (C) Representative images of cell migration of each cell line treated with 20 ng/ml rhBMP2 with or without siBMPR2. Slides were observed under 10 × magnification. (D) Quantitative data derived from (C). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted for each cell line. (E) Representative images of cell migration for each cell line. A549 and H1299 cells were treated with 10 ng/ml rhBMP2 or transfected with siBMP2. Slides were observed under 10 × magnification. (F) Quantitative data derived from (E). Bar graphs represent the average number of migrated cells ± SD. At least three fields were measured for each condition. The p-value was determined by Student’s t test (*p < 0.05, **p < 0.01, ***p < 0.001). | PMC9522928 | 41598_2022_20788_Fig4_HTML.jpg |
0.462382 | 8f81be0221c243f0a7b3faf85c493620 | The depletion or inhibition of SMAD pathway attenuates lung cancer cell migration. (A) The cell migration abilities were reduced in SMAD1/5-depleted cells. Slides were observed under 10 × magnification. (B) Quantitative data derived from (B). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted for each condition. (C) Representative images of cell migration for each cell line. Cells were treated with 20 ng/ml rhBMP2 with or without BMP signaling inhibitor LDN193189 as indicated. Slides were observed under 10 × magnification. (D) Quantitative data derived from (C). Bar graphs represent the average number of migrated cell ± SD. At least three fields were counted for each condition. The p-value was determined by Student’s t test (*p < 0.05, **p < 0.01, ***p < 0.001). | PMC9522928 | 41598_2022_20788_Fig5_HTML.jpg |
0.441603 | d4f120862dbf4ff68f388ec0bb2349d6 | Inhibition of BMP2 decreased metastasis in a CL1-5 orthotopic mouse model. (A) A schematic diagram showing the animal experiment. CL1-5 cells stably expressing shLacZ or shBMP2 Luc/GFP were injected into the right lungs of NOD-SCID mice. IVIS analysis was conducted at 7, 14, 28, and 35 days after injection. (B) The body weights of mice were measured three times per week after tumor injection. (C) Metastasis in shLacZ and shBMP2-CL1-5-Luc/GFP groups was measured by IVIS until sacrifice. (D,E) Metastastic lesions in the lungs (D) and nearby organs (E) were analyzed by IVIS after sacrifice. (F) Hematoxylin and eosin (H&E) and IHC stains in mouse right lung tissue for the indicated proteins. Slides were observed under 40 × magnification. Error bars represent SD, and p-value was determined by Student’s t test (*p < 0.05, **p < 0.01, ***p < 0.001). | PMC9522928 | 41598_2022_20788_Fig6_HTML.jpg |
0.48246 | 0602c4fe034140a7b7898cbc4aa8178d | Middle Pleistocene sites dated to MIS 13-11 in Europe. 1. Tunel Wielki Cave; 2. Trzebnica 2; 3. Rusko 33, 36 & 42; 4. Medzhibozh 1; 5. Korolevo; 6. Vértesszölös 2; 7. Bilzingsleben; 8. Račinĕves 9. Karlštejn-Altán; 10. Miesenheim I; 11. Kärlich-Seeufer; 12. Waverly Wood; 13. Happisburgh Site 1; 14. Warren Hill; 15. High Lodge; 16. Beeches Pit; 17. Hoxne;18. Elveden; 19. Barnham; 20. Clacton-on-Sea; 21. Swanscombe; 22. Boxgrove; 23. Cagny-la-Garenne; 24. Ferme de l’Epinette; 25. “Rue de Cagny”; 26. Saint-Pierre-les-Elbeuf; 27. Menez Dregan; 28. La Celle; 29. St. Colomban; 30. La Grande Vallé; 31. Terra Amata; 32. Arago; 33. Atapuerca Galeria; 34. Aridos; 35. Ambrona; 36. Gruta da Aroeira; 37. Visogliano 38. Ficoncella; 39. Fontana Ranuccio; 40. Castel di Guido; 41. Valle Giumentina; 42. Isernia-la-Pineta; 43. Guado San Nicola; 44. Marathousa; 45. Dealul Guran (All site details and references in Supplement Table 1). Map generated using QGIS v. 2.14 (qgis.org), digital elevation model modified from STRM37 raster data, boundaries and river layers modified from Natural Earth (naturalearthdata.com) vector data. | PMC9523034 | 41598_2022_20582_Fig1_HTML.jpg |
0.472548 | b8622da881e14c5ea2f9d53f092f9347 | Location of Tunel Wielki Cave. A. Sadlane rocks with entrances of Tunel Wielki Cave on the top and two other archaeological sites 'Nad Niedostępną' and 'Pod Tunelem' Rockshelters located underneath. B. LiDAR map of a karstic region of the Sąspów and Prądnik valleys with location of Tunel Wielki Cave and other cave archaeological sites. C. Section through the Sadlane rocks. D. Plan of Tunel Wielki Cave with the exact location of the archaeological trenches (plan based on Madeyska41 and 1967/68 fieldwork documentation). | PMC9523034 | 41598_2022_20582_Fig2_HTML.jpg |
0.47657 | d74ea0be1f6143988a0695ec1d9f1109 | Cross section of 2018 fieldwork in Tunel Wielki Cave and distribution of carnivores which are chronological markers within different Pleistocene layers. Layer F is marked in red. | PMC9523034 | 41598_2022_20582_Fig3_HTML.jpg |
0.46521 | 2295360ff2ec41af9cd19948ed3ca09b | Tunel Wielki Cave. Planigraphy of stone artefacts at different depths under the surface. Layer F is the uppermost one of the whole package of Pleistocene loams. It was preserved in the form of an inclined lens surrounded by the underlying strata, which were found in the form of circles around layer F. The stratigraphic position of the layer and the artefacts was caused by creeping processes leading to the slow movement of the whole loam package toward the vertical chimney in the bottom of the bedrock. | PMC9523034 | 41598_2022_20582_Fig4_HTML.jpg |
0.406076 | 8a5a789079f242f984e333831e6471f3 | Tunel Wielki Cave. 1–2. Cores on flakes; 3–4. Cores made on flint nodules, with visible lower platform removals and crushes. | PMC9523034 | 41598_2022_20582_Fig5_HTML.jpg |
0.471591 | 3cbb60c4773540d29223c87db3218825 | Lithic tools from Tunel Wielki Cave. 1. Kombewa flake; 2. Kombewa flake with a retouched edge; 3. Broken Kombewa flake; 4. Longitudinally retouched flake; 5. Transversally retouched flake; 6. Flake with heavily postdepositionally damaged edges. Its big size, longitudinal curvature, massive bulb and equal thickness throughout its whole length indicate the use of free-hand technology; A. Hertzian cone of the unsuccessful flake detachments; B. Protruding point of percussion on the ventral side of the flake. | PMC9523034 | 41598_2022_20582_Fig6_HTML.jpg |
0.513375 | 4fb833d425e34d60a0a8c2972c44362a | Bipolar-on-anvil reduction scheme and the technological features which might be observed on debitage. | PMC9523034 | 41598_2022_20582_Fig7_HTML.jpg |
0.451871 | 7c8aa4e97bb046b1b38aebe14d70c58e | Reconstructed chronology of the carnivores and small mammals from Tunel Wielki Cave based on their morphology. The thin lines refer to the occurrence of the species in Central Europe. Thick lines refer to the chronology of the individuals of the morphology observed in Tunel Wielki Cave. The dotted line refers to the probable occurrence. The red bar indicated the most probable chronology of the human occupation in Tunel Wielki Cave based on mammals' taxonomy and morphology. | PMC9523034 | 41598_2022_20582_Fig8_HTML.jpg |
0.427 | b7e53e820e77416bb5ca5c352e030e4b | Collection of platelet-rich fibrin as fibrin clot. | PMC9524380 | jiao-18-5-405_f001.jpg |
0.436763 | 12ac5629fc4549bcbf5a526161440005 | Preparation of platelet-rich fibrin buffers. | PMC9524380 | jiao-18-5-405_f002.jpg |
0.449105 | bb50923f71df4cd586a62c369f9f3990 | Platelet-rich fibrin buffers were placed lateral to the cartilage graft in external auditory canal. | PMC9524380 | jiao-18-5-405_f003.jpg |
0.459731 | c6829db3922c4cca9b87f51d63d51457 | Platelet-rich fibrin buffers were used in middle ear to prevent cartilage graft medialization. | PMC9524380 | jiao-18-5-405_f004.jpg |
0.441811 | f57b36596ae749ddabdd2a685282746d | Map of the potential grazing values in summer pastures of northern Fennoscandia. The reclassification is based on Corine land-cover 2018 (detailed in Table 1). This map was created with QGIS version 3.4.7, accessed on www.qgis.org. The country borders were from Eurostat ©EuroGeographics. | PMC9525264 | 41598_2022_20095_Fig1_HTML.jpg |
0.403049 | 11b3e03e35944919843cd552aedab216 | Maps over northern Fennoscandia depicting the (a) private cabins and outdoor tourism accommodations, (b) road and railway network, (c) land-based industrial facilities, (d) land-based wind energy, (e) the proportion of area primarily used for forestry, (f) the number of large predator species permanently present. For each map, the distribution of the pressure per potential grazing value is given with bar graphs. The error bars show standard errors. These maps were created with QGIS version 3.4.7, accessed on www.qgis.org. The country borders were from Eurostat ©EuroGeographics. *Note that, for Fig. 3a, for eight of the yellow grid cells, the total number of private cabins exceeds 500 and don’t contain any tourism accommodations. | PMC9525264 | 41598_2022_20095_Fig2_HTML.jpg |
0.483401 | 093c712f548047afb79e61232deb5976 | (a) Temperature changes over northern Fennoscandia for the last 60 years (1959 to 2018) coloured in shades of red (see legend). The residuals of all the models (linear and quadratic) were normal. The area covered by blue hatched lines are the areas where the quadratic models were a better fit than the linear models, and were therefore used to model temperature change over time. The residuals of these models were normal and not auto-correlated. 4.3% of the linear models were serially auto-correlated, therefore excluded and shown in white. This map was created with QGIS version 3.4.7, accessed on www.qgis.org. The country borders were from Eurostat ©EuroGeographics. (b) Distribution of the multiple pressures (co-occurring land-uses in shades of blue and co-occurring predator species in shades of yellow) at the different rates of temperature change up to 1.984 °C. For each specific rate of temperature change, the percentages show the extent (in number of grid cells) under cumulative pressures. Note that six grid cells contained five land-uses but were not included in this graph for visual purposes. | PMC9525264 | 41598_2022_20095_Fig3_HTML.jpg |
0.414233 | 2bd3c4714cca4b6db3c96d25c6e50ffe | (a) Map showing the cumulative pressures affecting extensive domestic grazing over northern Fennoscandia. Temperature changes modelled for 1959 until 2018 are depicted with contour lines. Note that the bivariate colour legend ends at four land-uses co-occurring in one grid cell for visual purposes, but six grid cells contained five land-use pressures, as well as predator presence (five grid cells were located in central Sweden and one in Finland next to the Russian border). This map was created with QGIS version 3.4.7, accessed on www.qgis.org. The country borders were from Eurostat ©EuroGeographics. (b) Distribution of the multiple pressures (co-occurring land-uses in shades of blue and co-occurring predator species in shades of yellow) over the different types of grazing land. For each potential grazing value, the percentages show the extent (in number of grid cells) under cumulative pressures. Note that six grid cells contained five land-uses but were not included in this graph for visual purposes. | PMC9525264 | 41598_2022_20095_Fig4_HTML.jpg |
0.462071 | a5888f5e97734e778d1f10de7b448716 | Location of the research area and the distribution of sampling points (created by Arcgis 10.8, http://desktop.arcgis.com/cn/). | PMC9525309 | 41598_2022_20865_Fig1_HTML.jpg |
0.428444 | a485058958a44643b4513186c8195a8f | Spatial distribution of Pi and NPI of heavy metal in the study area (created by Arcgis 10.8, http://desktop.arcgis.com/cn/). | PMC9525309 | 41598_2022_20865_Fig2_HTML.jpg |
0.445838 | 88e1a91b5e494cfeb5dd1d5a53af7834 | Spatial distribution of single ecological risk index (E) of heavy metals (created by Arcgis 10.8, http://desktop.arcgis.com/cn/). | PMC9525309 | 41598_2022_20865_Fig3_HTML.jpg |
0.434163 | f58fd1a0b2644787970c56bf78cdfbb8 | Spatial distribution of RI of heavy matals(created by Arcgis 10.8, http://desktop.arcgis.com/cn/). | PMC9525309 | 41598_2022_20865_Fig4_HTML.jpg |
0.437204 | 6050217db5b14e3b8ad616147199673d | Ecological risk warning assessment of heavy metals in the study area (created by Arcgis 10.8, http://desktop.arcgis.com/cn/). | PMC9525309 | 41598_2022_20865_Fig5_HTML.jpg |
0.466373 | aed30a1aee974728abb1cde09a88f1c1 | A, Linear streak of alopecia right forehead, right medial eyebrow, right medial lash line. B, Loss of medial lash line close-up image. C, Dermoscopic view showing loss of medial eyelashes. D, Dermoscopic image highlighting yellow dots and exclamation point hairs. E, Dermoscopic image of scalp | PMC9525728 | gr1.jpg |
0.469747 | cb803ea9c4ac47f495a510a7ae48da5f | H&E stain 10x magnification showing a reduction in the number of hair follicles with distortion in the appearance of residual follicles. Mild perifollicular chronic inflammation is seen without evidence of interface changes. | PMC9525728 | gr2.jpg |
0.43841 | ad2e55d7191a40aaa2bce00ca91db7c3 | Generic IoT architecture [4]. | PMC9525787 | IJTA2022-5394942.001.jpg |
0.453742 | fc96ea6188cf4765b213a146cba6e8fb | Responses to a challenge of different PUFs on different ICs [29]. | PMC9525787 | IJTA2022-5394942.002.jpg |
0.475825 | e2c35ee437804e78bef193ced176e222 | Establishing challenge-response pairs (CRP). | PMC9525787 | IJTA2022-5394942.003.jpg |
0.392012 | 8a20f53a935642a099b55881b1dd6cb9 | The steps used by the server to obtain helper data w, secret session key k, and authentication hash h. | PMC9525787 | IJTA2022-5394942.004.jpg |
0.382957 | ad5d27a58bc04d97a7add10cd8f31856 | Structure of the system used to obtain secret session key and authentication hash at the client side. | PMC9525787 | IJTA2022-5394942.005.jpg |
0.506575 | d9dbe8be1a624f388634f81d52c0800d | Ambulance-based smart emergency medical response system. | PMC9525787 | IJTA2022-5394942.006.jpg |
0.429237 | fd8509d2228c4203a2e5413c7c8fdcfc | Registration phase of the emergency medical response system. | PMC9525787 | IJTA2022-5394942.007.jpg |
0.450708 | 19fb063e1e98427cab481378f1111e2f | Handheld device role specifications. | PMC9525787 | IJTA2022-5394942.008.jpg |
0.422563 | 71f08c9d5e1d48068beb19d2fbe73bc5 | Server (S) role specifications. | PMC9525787 | IJTA2022-5394942.009.jpg |
0.477749 | 1229dae285c2431d91ea2db9ff078ddc | Transporter role specifications. | PMC9525787 | IJTA2022-5394942.010.jpg |
0.406564 | db337a2ba822434a82f781fe442565cb | Edge device role specifications. | PMC9525787 | IJTA2022-5394942.011.jpg |
0.457228 | b248d197635c45128507cb7715104c6f | Smart emergency medical response system protocol simulation on SPAN. | PMC9525787 | IJTA2022-5394942.012.jpg |
0.470216 | af68cd443aef4f2f9d2673d8e600aa9b | The results using OFMC and CL-AtSe backends. | PMC9525787 | IJTA2022-5394942.013.jpg |
0.418799 | b037645a23b3439a9502502b249e9404 | Identification of transcription factors associated with MYC redistribution at AR- and HOXB13-occupied sites. A Ranked order depiction of genes whose expression correlate with MYC in an institutional cohort of 177 laser-capture microdissected prostate cancer tumor foci. B Schematic of the strategy used to identify upstream transcription regulators based on co-occupied peaks in LNCaP ChIP-seq data. anti-MYC [22], anti-AR, and anti-HOXB13 ChIP-seq data [23] used for analyses. C, D Bar plots showing the total peak number of MYC co-occupied sites, characterized as “core” or “redistributed” peaks, for anti-AR (C) and anti-HOXB13 (D) ChIP-seq. E Venn diagraph showing the overlap between transcription regulators identified by MYC/AR and MYC/HOXB13 co-occupied genes and nominated Ingenuity Upstream Regulator Analysis | PMC9526773 | 12672_2022_565_Fig1_HTML.jpg |
0.421858 | 1b393dfc53e94dda8ef04a7bdbfa8d4e | Decreasing association of KMT2A expression with prostate cancer drivers during primary disease progression. A–C Pearson correlation of the log2 CPM expression level for KMT2A with a 54-gene ssGSEA MYC activity score (A), a 266-gene ssGSEA AR activity score (B), or the log2 CPM expression level for HOXB13 (C) in a cohort of 177 laser capture microdissected foci of human prostate tumors. The error bars represent the 95% confidence bands for linear regression. For each correlation, the foci are subdivided into Gp3 (left), Gp4 (middle, including intraductal tumors), and Gp5 (right) | PMC9526773 | 12672_2022_565_Fig2_HTML.jpg |
0.54018 | 848623c66b064e0784a88207a359686e | Inverse association of KMT2A expression with prostate cancer drivers in metastatic disease. A–F Pearson correlation of the log2 CPM expression level for KMT2A with the 54-gene ssGSEA MYC activity score (A, B), a 266-gene ssGSEA AR activity score (C, E), or the log2 CPM expression level for HOXB13 (D, F) in the LuCaP series of patient-derived xenografts (N = 25) (A, C, D) or the West Coast Dream Team-Prostate Cancer Foundation metastatic CRPC cohort (N = 99) (B, E, F). The error bars represent the 95% confidence bands for linear regression | PMC9526773 | 12672_2022_565_Fig3_HTML.jpg |
0.485706 | 6101eba90dec48f4ac24302fad16fc9f | Inverse relationship between PLA2G4F and KMT2A expression in metastatic prostate cancer. A Expression of KMT2A across the LuCaP PDX models in our study displayed as a heatmap, indicating which models are classified as KMT2A high or low. B Heatmap of anti-AR and anti-HOXB13 ChIP-seq [29] peak signals (aggregated across samples as indicated) around TSS regions (± 3 kb) in LuCaP PDX's with differential KMT2A expression. Each row is a peak ranked by KMT2A low to high. The location of PLA2G4F on heatmap is marked by a black bar. C Functional enrichment from Ingenuity Upstream Pathway Analysis of anti-AR and anti-HOXB13 ChIP-seq differential peaks overlapping genes for pathways with P < 0.1. Red indicates that PLA2G4F is present in the pathway gene set. D Integrative genome viewer tracks of the PLA2G4F gene locus from anti-AR and anti-HOXB13 ChIP-seq. LNCaP DNase-hypersensitivity regions shown in blue. E–H Spearman correlation of the log2 CPM expression level of PLA2G4F with log2 CPM expression level of KMT2A (E, G) or the 54-gene ssGSEA MYC activity score (F, H) in the LuCaP (E, F) or the West Coast Dream Team-Prostate Cancer Foundation metastatic CRPC cohort (G, H). Samples with log2 CPM PLA2G4F < 0 were excluded. The error bars represent the 95% confidence bands for linear regression | PMC9526773 | 12672_2022_565_Fig4_HTML.jpg |
0.429114 | db84adf2ba504d30a4c417417194def3 | Arachidonic acid (ArA) metabolism is associated with KMT2A expression. A Time course of [18F]ArA uptake in LuCaP PDX organoids (N = 15) classified as either KMT2A-high (red) or KMT2A-low (blue). Individual organoids are given by light shaded lines, with each line representing the median uptake of 2–5 replicates. Dark shaded lines represent the median uptake for KMT2A-high or KMT2A-low PDX organoids. Results are expressed as median uptake per 1 million cells. B. Percent [18F]ArA uptake in LuCaPs based on KMT2A expression at 120 min. Line at median. Each organoid (representing 2–5 replicate experiments) plotted as open circles (N = 9 high, N = 6 low). P = 0.026 by Mann–Whitney U test. C, D Spearman correlation of the log2 CPM expression level of PLA2G4F with the percent [18F]ArA uptake in LuCaPs at 120 min (C) or the rate of uptake over 2 h, measured by the slope of linear regression (D). Cases are colored by KMT2A expression status. The error bars represent the 95% confidence bands for linear regression of each scatter plot | PMC9526773 | 12672_2022_565_Fig5_HTML.jpg |
0.455289 | 7bc4237b8a4b40b89d3ee30905b9e7c6 | Evolutionary relationships of species in the Hyloscirtus larinopygion group, based on the mitochondrial gene 16S under ML criterion.Clade support (bootstrap %) are in blue. The new species is in red. | PMC9527025 | peerj-10-14066-g001.jpg |
0.436402 | 9618afade8a64fc5bca0c793d3b4ca58 | Dorsal coloration of Hyloscirtus sethmacfarlanei sp. nov.(A) Female holotype (DHMECN 14416). (B) Juvenile paratype (DHMECN 17554). (C) Juvenile paratype (DHMECN 14549). Photographs: MYM. | PMC9527025 | peerj-10-14066-g002.jpg |
0.374141 | 968e3ea233234e54b3d2849665f5478f | Linear regression of divergence time vs genetic distance for some Hyloscirtus species of the Hyloscirtus larinopygion group.Line (A) is the unconstrained regression line. Line (B) is constrained to pass through the origin. Red segments represent the ranges of genetic distances (2.2–2.9%) and inferred divergence times between H. sethmacfarlenei sp. nov.and H. tigrinus, the known species with the smallest genetic distance to the new species. The estimated divergence time should be considered only a rough estimate. | PMC9527025 | peerj-10-14066-g003.jpg |
0.431924 | e6e5227b206c4e07978f02765a1dece1 | Dorsal, lateral, and ventral views of the preserved holotype of Hyloscirtus sethmacfarlanei sp. nov. (DHMECN 14416).Photographs: MYM. | PMC9527025 | peerj-10-14066-g004.jpg |
0.4451 | 2785925fbe5649c98e3496872100385d | Details of the hand and foot of the preserved holotype of Hyloscirtus sethmacfarlanei sp. nov. (DHMECN 14416).Photographs: MYM. | PMC9527025 | peerj-10-14066-g005.jpg |
0.416873 | 283c3c4452f54615bb6c21e895035c75 | Ventral coloration of Hyloscirtus sethmacfarlanei sp. nov.(A) Female holotype (DHMECN 14416). (B) Juvenile paratype (DHMECN 17554). (C) Juvenile paratype (DHMECN 14549). Photographs: MYM. | PMC9527025 | peerj-10-14066-g006.jpg |
0.467186 | 121d4f3509524be4acc192dd19ffee5c | Lateral detail of head in life of the type series of Hyloscirtus sethmacfarlanei sp. nov.(A) Female holotype (DHMECN 14416). (B) Juvenile paratype (DHMECN 14549). Juvenile paratype (DHMECN 14549), note coloration in nictitating membrane. Photographs: MYM. | PMC9527025 | peerj-10-14066-g007.jpg |
0.432624 | 6cf05743656a4310adcf83c65b3ca1e3 | Comparison in life of Hyloscirtus sethmacfarlanei sp. nov. with six species of Hyloscirtus from the H. larinopygion group from the Andes of Ecuador.(A) Hyloscirtus sethmacfarlanei sp. nov., female holotype (DHMECN 14416). (B) Hyloscirtus sethmacfarlanei sp. nov., juvenile paratype (DHMECN 14549). (C) Hyloscirtus princecharlesi (photographic record QCAZ). (D) Hyloscirtus larinopygion, photographic record QCAZ. (E) Hyloscirtus lindae (DHMECN 12483 ). (F) Hyloscirtus pantostictus (photographic record QCAZ). (G) Hyloscirtus psarolaimus (DHMECN 6493). (H) Hyloscirtus pacha (DHMECN 12111). Photographs: JPRP, MYM, Santiago Ron. QCAZ, Jorge Brito. | PMC9527025 | peerj-10-14066-g008.jpg |
0.419784 | efbbda6d9d1049de9a4f28ee44bd2bc2 | Vent condition in preserved specimens of six species of Hyloscirtus in the H. larynopygion group.(A) Hyloscirtus larinopygyion (DHMECN 3799). (B) Hyloscirtus psarolaimus (DHMECN 6493). (C) Hyloscirtus sethmacfalanei sp. nov. (DH MECN 14416). (D) Hyloscirtus pacha (DHMECN 12111). (E) Hyloscirtus lindae (DHMECN 12483). (F) Hyloscirtus tapichalaca (DHMECN 9686). Photographs: MYM. | PMC9527025 | peerj-10-14066-g009.jpg |
0.432267 | ed4941ffa4864467a972c0ddfaeceeb6 | Cloacal ornamentation detail in life of the type series of Hyloscirtus sethmacfalanei sp. nov.(A) Female holotype (DHMECN 14416). (B) Juvenile paratype (DHMECN 14549 ). (C ) Juvenile paratype ( DHMECN 17554 ). (D) Uncollected juvenile. Gray arrows shows paracloacal folds in relation with the supracloacal fold and the vent. No scale to facilitate comparisons between different sizes of the specimens. | PMC9527025 | peerj-10-14066-g010.jpg |
0.439291 | b6dad113717d45e08e0c9282e50b6eac | Live individiuals of Hyloscirtus sethmacfarlanei sp. nov. in situ.(A) Female holotype (DHMECN 14416). (B) Juvenile paratype (DHMECN 14549). (C) Juvenile, not collected, in its natural habitat. (D) Same juvenile adopting defensive behavior. Photos: LJ, FR, JPRP. | PMC9527025 | peerj-10-14066-g011.jpg |
0.395063 | 9a94b86c0d9a4e36a6dfdd33c954d1bf | Osteological details of the cranium of the adult female holotype (DHMECN 14416) Hyloscirtus sethmacfarlanei sp. nov..(A) Dorsal view. (B) Ventral view. (C) Anterior view. (D) Lateral view. Labels: AP, alary process of premaxilla; AS, angulosplenial; COL, columella; D, dental; EXO, exoccipital; FP, frontoparietal; FPF, frontoparietal fontanelle; MMK, mentomeckelian bone; MX, maxilla; NA, nasal; NPL, neopalatine; OC, occipital condyle; PM, premaxilla; PO, prootic; PS, parasphenoid; PT, pterygoid; QJ, quadratojugal; SQ, squamosal; SE, sphenethmoid; SM, septomaxilla; V, vomer. | PMC9527025 | peerj-10-14066-g012.jpg |
0.481145 | e1af310fdacf4456b2b705a2f405fb74 | Dorsal view of CT scan skull detail of Hyloscirtus sethmacfarlanei sp. nov. in comparison with other related members of the H. larinopygion group.(A) Hyloscirtus sethmacfarlanei sp. nov. (DHMECN 14416). (B) Hyloscirtus larinopygion (DHMECN 3799). (C) Hyloscirtus pacha (DHMECN 12111). (D) Hyloscirtus psarolaimus (DHMECN 6493). (E) Hyloscirtus lindae (DHMECN 12483). (F) Hyloscirtus tapichalaca (DHMECN 9686). Individual skull diagnostic bones given false colors. Blue: alary process of the premaxilla. Bright yellow: septomaxilla. Brown: maxilla. Purple: sphenoides (in H.tapichalaca this is fused with nasals). Light blue anterior: neopalatine. Light blue posterior: pterigoides. Red anterior: frontoparietals. Posterior red punctuation represents conjunction with exoccipital. White: frontoparietal fontanelle. Light yellow: prootic. Green: squamosal. Pink: quadratojugal. | PMC9527025 | peerj-10-14066-g013.jpg |
0.451248 | 125f11e461fe4b91915bb362e9686218 | CT scan of the ventral view of the forelimb bones of the holotype of Hyloscirtus sethmacfarlanei sp. nov. (DHMECN 14416).(A) Distal clawed phalanges (light blue). (B) Medial phalanges (dark blue). (C) Proximal phalanges (red). (D) Prepolex (light green). (E) Distal carpal II (purple). (F) Fused distal Carpals 3+4+5 (pink). (G) Radiale (orange). (H) Ulnare (yellow). (I) Radioulna (dark green). (J) Humerus (brown). | PMC9527025 | peerj-10-14066-g014.jpg |
0.442218 | 08692ea924004f81b02081a973db9295 | Comparison of the CT scans of the posteromedials of the hyobranchium in different species of the Hyloscirtus larinopygion group.(A) Hyloscirtus sethmacfarlanei sp nov. holotype (DHMECN 14416). (B) Hyloscirtus larinopygion (DHMECN 3799). (C) Hyloscirtus lindae (DHMECN 12483). (D) Hyloscirtus psarolaimus (DHMECN 6493). (E) Hyloscirtus pacha (DHMECN 12111). (F) Hyloscirtus tapichalaca (DHMECN 9686). | PMC9527025 | peerj-10-14066-g015.jpg |
0.521995 | c85bf05d2a2c4f7da8c7b7c95f81a4aa | Maps of northwestern South America showing the ecological niche modeling for all species of the northern clade of the Hyloscirtus larinopygion species group (yellow to red shadows).(A, B) Both maps show the same ecological niche model but species were divided into two maps to allow locality points for all species to be included. Type locality of H. sethmacfarlanei sp. nov. indicated by a black triangle in (A). | PMC9527025 | peerj-10-14066-g016.jpg |
0.480198 | b12f777b109a449caa9df2a7e3c7e5eb | Hyloscirtus sethmacfarlanei sp. nov., at the type locality and its habitat.(A) Humid cloud forest with Guzmania sp. bromeliads at type locality. (B) Female Holotype (DHMECN 14416). (C) Juvenile paratype (DHMECN 14549). (D) Uncollected juvenile. Photographs: FR, JPRP. | PMC9527025 | peerj-10-14066-g017.jpg |
0.396522 | 03487ab52688462f8b25ca4b40994658 | Measles protection for different age groups according to parents reporting on their youngest child | PMC9527387 | 12889_2022_14075_Fig1_HTML.jpg |
0.406628 | 98697aab0944477d8f26cb84885e1778 | Knowledge about the measles vaccine and the mandate in parents by socio-economic status. Notes: Knowledge about the measles vaccine = Score, Range 0–7. Knowledge about the measles vaccine mandate = Score, Range 0–5. Error bars = 95% CI. Education = ISCED classification [38], Income = OECD equivalence scale [39] | PMC9527387 | 12889_2022_14075_Fig2_HTML.jpg |
0.404006 | e1424d2fabd2439f96267ef52d12237f | Relationship between level of reactance and likelihood to be vaccinated (A) and vaccination intention (B). Notes: Estimates are not adjusted; gray bands indicate the 95% confidence intervals. Figure A = Results from two logistic regressions, i.e., probability of a child having been vaccinated with pneumococcal (blue curve) or hexavalent vaccine (green curve) by level or reactance. Figure B = Results from three linear regressions, i.e., HPV (red curve), meningococcal C (green curve) and TDAP vaccination intention (blue curve) by level of reactance | PMC9527387 | 12889_2022_14075_Fig3_HTML.jpg |
0.467793 | 1372ed24ef9648eca76388332fa8c94e | Mediation analysis. Note: All coefficients are β coefficients. Bold denotes significant at p < 0.05. The path coefficients after the slash indicate the relation between institutional trust and attitude towards mandate controlled for reactance. (M) indicates a significant mediation effect | PMC9527387 | 12889_2022_14075_Fig4_HTML.jpg |
0.461485 | 13982f7c8f954689acc0192f05cc1ce5 | (a) STM image of ML Fe islands having the three distinct
reconstructions:
I, II, and III (V = −10 mV, I = 4 nA, T = 6.5 K). Furthermore,
a DL Fe island can be identified as a bright stripe. (b–e)
Atomically resolved STM images of (b) the Nb(110) substrate and (c–e)
of the individual Fe ML reconstructions. The blue rectangles indicate
the size and orientation of the Nb(110) surface unit cell determined
from (b) for comparison (T = 6.5 K; b: V = −10 mV, I = 5 nA;
c: V = −10 mV, I =
5 nA; d: V = −10 mV, I = 7 nA; e: V = −5 mV, I = 100 nA). (f) Point spectra taken on the substrate
and the respective Fe ML reconstructions as indicated. Vertical blue
dashed lines mark the Nb(110) surface state at negative bias and a
state of the Fe ML at positive bias (Vstab = 1 V, Vmod = 10 mV, Istab = 0.5 nA, T = 4.5 K). | PMC9527798 | nn2c03965_0001.jpg |
0.42208 | 237b1730c4d7425b9272d0e0b9be32ca | (a–c) Spin asymmetry maps ( = −0.5 T, = +0.5 T) of the different types
of Fe ML reconstructions shown in the STM-image in (d) taken with
the same spin-polarized STM tip (I = 1 nA, Vmod = 50 mV, V = 400 mV
(a), V = 320 mV (b), V =
375 mV (c)). The outline of the individual islands is marked
using dashed lines with a color according to the code. (e) Hysteresis
loops of the same three islands, calculated from spin-resolved dI/dV values at the indicated bias voltages
averaged over selected areas of each of the different Fe ML reconstructions.
(f) Exemplary sketch of the determined magnetizations of the tip and
type I Fe ML island for different parts of the hysteresis loop as
indicated by the according numbers in (e). Note that the magnetic
field dependence of the tip magnetization is the same for all three
hysteresis loops. | PMC9527798 | nn2c03965_0002.jpg |
0.439738 | 9b2c12ec7f5342c5a55359d55dfd994f | (a–c)
Left panels are STM images of three Fe ML islands
of each type of reconstruction as indicated (I =
1 nA, V = −6 mV, T = 4.5 K). Right panels are spectroscopic line profiles across
each of the island types along the lines in the direction of the arrows
(Istab = 400 pA, Vmod = 0.1 mV, Vstab = 4 mV). The white dots on the arrows in the STM images correspond
to the positions where the spectra between the white vertical lines
of the spectroscopic line profiles have been taken. (d) Right panel:
Spectra averaged on top of the three islands from the spectroscopic
line profiles in (a–c). Left panel: Spectrum averaged on an
area of the bare Nb(110) surface. Gray or black dashed horizontal
lines in the spectra are at e·V = ±(Δt – Δs), e·V = ±Δt, and e·V = ±(Δt + Δs). All measurements were done at Bz = 0 T. | PMC9527798 | nn2c03965_0003.jpg |
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