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0.412894 | 4b90a5dcdcc74213b7b2fbf808b2b0c8 | Best crRNA candidates for Cas13a protein from in silico docking experiments. The 3-D visualization shows the spatial coordinates of each crRNA candidate model (only 10 best models were considered) after in silico docking with the corresponding Cas13 protein. Each pink dot represents the centre of mass calculated from all atoms of the macromolecular structure model for each crRNA candidate. The GT crRNA is marked as a black dot, and its closest crRNA candidates in terms of Euclidian distance are highlighted as blue dots. The multiple sequence alignment compares the RNA sequences of the GT crRNA with those of the best crRNA candidates. The different shades of blue show the percentage identity, with the identity threshold set to 50%, highlighting variations in the RNA sequences. The 3-D structure shows an example of docking between the receptor (Cas protein) and the ligand (crRNA). The Cas proteins are in grey, the GT crRNA is coloured in magenta, and the best crRNA candidate model is highlighted in green with its identifier given above (GenomeID_CRISPRarray_CRISPRrepeat_modelnumber) | PMC9547417 | 13062_2022_339_Fig5_HTML.jpg |
0.436421 | 3f6be33025934dd093a3e0a7dc0b4631 | (a): Erosions involving the upper and lower lips. (b): Erythematous to violaceous papules over dorsum of bilateral feet | PMC9549559 | IDOJ-13-407-g001.jpg |
0.407009 | 63e2929e472c4e72a259ba679f2d920f | CECT abdomen (a) axial image and (b) coronal image demonstrating a round to oval well-defined heterogeneously enhancing exophytic mass measuring 1.7 × 2.3 × 2.1 cm (AP × TR × CC) arising from interpolar region of left renal cortex without any evidence of internal calcification, fat or air density which is laterally abutting the spleen with loss of fat planes without any obvious features of parenchymal infiltration | PMC9549559 | IDOJ-13-407-g002.jpg |
0.453288 | 07dfa1e233114083b5990c823a7338b6 | (a): Biopsy (oral mucosa) revealing focal suprabasilar acantholytic cleft and interface dermatitis with many apoptotic cells, basal layer damage, infiltration of dermal lymphocytes, and pigment incontinence (H&E 10×). (b): Direct immunofluorescence evaluation of perilesional specimen from dorsum of right foot revealing intercellular suprabasal deposition of IgG and IgA in a fishnet pattern and linear deposition of IgG, IgA, and C3 along dermoepidermal junction (40×). (c): Ultrasound-guided core needle renal biopsy showing compact nests and sheets of cells with clear cytoplasm and distinct membrane consistent with renal cell carcinoma of clear cell subtype (H&E 10×) | PMC9549559 | IDOJ-13-407-g003.jpg |
0.381526 | a493ace8ff6d4e579ab5ee75513ca09d |
A The position of the long intestinal tube (LIT) seemed to be appropriate based on the radiographic evaluation conducted after the procedure. B, C Contrast-enhanced CT revealed the LIT partially located in the gastric wall with a subtle edematous change (white arrowhead) (B: reconstructed coronal image, C: enlarged axial image).
| PMC9550395 | 2432-0935-5-3-0141-g001.jpg |
0.417747 | d1a51a11f64b478d8890c1f3e346227f |
A, B Endoscopy revealed LIT penetration and traversal of the gastroesophageal wall (white arrow: entry, white arrowhead: exit). C, D LIT (black arrow) removal during the operation. E, F Follow-up endoscopy showed the submucosal tunnel formation between the abdominal esophagus and gastric cardia (white arrow: entry, white arrowhead: exit, comparison with A and B).
| PMC9550395 | 2432-0935-5-3-0141-g002.jpg |
0.399606 | f668750761e243aaa5a82268d5eaf923 | Framework diagram of IoT database. | PMC9550416 | JEPH2022-5143396.001.jpg |
0.536077 | 26eb87497a504290ba3ccb740a43aab7 | The dissemination path of network information. | PMC9550416 | JEPH2022-5143396.002.jpg |
0.470791 | cb682409dd0941b687db862dc071e8ab | Protection of personal information according to law. | PMC9550416 | JEPH2022-5143396.003.jpg |
0.450953 | f41286dd3b10471880ba2766923b3216 | Flowchart of big data distributed storage redundant data configuration under cloud computing. | PMC9550416 | JEPH2022-5143396.004.jpg |
0.402881 | 72d84d32c04e4a9580fb55621ff58ecc | 100 platform privacy policy sharing and utilizing special authorization. | PMC9550416 | JEPH2022-5143396.005.jpg |
0.536249 | 276607991c734167a6a5c7f6e101a2dc | Personal information security comparison. | PMC9550416 | JEPH2022-5143396.006.jpg |
0.524286 | bae6bc980e524042a44e87d8f23e7aad | Comparison of economic losses under IoT management. | PMC9550416 | JEPH2022-5143396.007.jpg |
0.412825 | deb16d11c88f4ee68e7a7c07111aefdd | Comparison of efficiency improvement. | PMC9550416 | JEPH2022-5143396.008.jpg |
0.468595 | 2f121f7868d34cca99e2ae9483efede1 | Comparison of management optimization of IoT in hospitals. (a) Original optimization management diagram. (b) Management diagram after IoT optimization. | PMC9550416 | JEPH2022-5143396.009.jpg |
0.379801 | 81617803f8cc47e6871fefc7d00142c9 | Effect of dietary zero-dimensional fullerenes (C60) supplementation on meat quality of finishing pigs (n = 6). (A) The pH values of longissimus dorsi muscle of finishing pigs at 45 min, 3, 12, 24, and 36 h post–slaughter; ∗P < 0.05 vs. control. (B) The color and marbling score of meat. (C) The mRNA expression of L-lactic dehydrogenase (LDH) gene. (D) Representative image of the longissimus dorsi muscle. Results on the column chart were expressed as the mean ± standard error. a, b, c Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr1.jpg |
0.471465 | debe7086672948bda7b44f3711b65f7c | Effect of dietary zero-dimensional fullerenes (C60) supplementation on fiber type and fatty acid metabolism of finishing pigs (n = 6). (A) The expression of the key genes, including myosin heavy chain (MyHC) IIx, MyHC I, MyHC IIa, MyHC IIb. (B, C) The expression of genes related to lipid metabolism. FATP1 = fatty acid transport protein 1; FAT/CD36 = fatty acid translocase; ACC = acetyl-CoA carboxylase; FAS = fatty acid synthase, HSL = hormone-sensitive lipase; CPT1B = carnitine palmitoyl transferase 1B; SREBP1c = sterol regulatory element-binding protein-1c; PPARγ = peroxisome proliferator-activated receptor γ. Results on the column chart were expressed as the mean ± standard error. a, b, c Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr2.jpg |
0.402034 | 53710bed2901418db392f7b5333a4f2c | Effect of dietary zero-dimensional fullerenes (C60) supplementation on longissimus dorsi (LD) fiber morphology and type composition of finishing pigs (n = 6). (A) Fiber morphology of LD muscle. (B) Fiber diameter of LD muscle. (C) Fiber density of LD muscle. Results on the column chart were expressed as the mean ± standard error. a, b Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr3.jpg |
0.389885 | 99157e05a8fe465d87640eedc7ad1a9e | Effect of dietary zero-dimensional fullerenes (C60) supplementation on antioxidative enzyme activities and malonaldehyde (MDA) content in the serum of finishing pigs (n = 6). (A) The antioxidative enzyme levels in serum of finishing pigs on d 30 of the trial, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px). (B) The antioxidative enzyme levels in serum of finishing pigs at the end of the trial. Results on the column chart were expressed as the mean ± standard error. a, b Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr4.jpg |
0.392883 | c329a6a8a7d64415a2100f0a404fa645 | Effect of dietary C60 supplementation on antioxidative enzyme activities and malonaldehyde (MDA) content in muscle and fat of finishing pigs (n = 6). (A) The antioxidative enzyme levels of longissimus dorsi muscle including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px). (B) The antioxidative enzyme levels of fat (n = 6). Results on the column chart were expressed as the mean ± standard error. a, b, c Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr5.jpg |
0.397409 | 8647782f36aa4847b07849a46c0ac8fb | Effect of adding C60 to diet on genes of glutathione peroxidase (GPX), GPX1, GPX 4, catalase (CAT), copper-zinc-superoxide dismutase (CuZnSOD), and manganese superoxide dismutase (MnSOD) mRNA expression in longissimus dorsi of finishing pigs (n = 6). Results on the column chart were expressed as the mean ± standard error. a, b, c Bars with different letters were declared significant at P < 0.05. | PMC9550521 | gr6.jpg |
0.480159 | 17c6a4f0c88446008ea26b6354b41da2 | The Brazilian economy–Selected indicators, 2000–2020.Sources–System of National Accounts (IBGE) and Confederação Nacional da Indústria (CNI). Obs.–Capacity utilization rate is seasonally adjusted. | PMC9550638 | gr1_lrg.jpg |
0.385507 | 5f628c952fc940d88d5074c3c0b026de | Quarterly real growth rate of manufacturing value added–2000–2020. Sources–System of National Accounts (IBGE). | PMC9550638 | gr2_lrg.jpg |
0.444334 | 4257044a79c24980ad33824cee692c27 | A combined volume- and region-based analysis method (above) using the MPRAGE magnetic resonance imaging (MRI) sequences identified grey matter (GM) volume loss in the right (z-score: 12.5) and left (z-score: 10.25) parietal cortex. Atrophic changes with increased cerebrospinal fluid (CSF) volume were identified in the left orbitofrontal cortex (z-score: 9.65), right (z-score: 9.2) and left (z-score: 7.32) occipital cortex, and the right mesiotemporal cortex (z-score: 5.98). FLAIR and SWI sequences (central) showed a small brain parenchymal defect right temporal with hemosiderin deposits after cavernomectomy. The inset shows the electroencephalography independent component analysis maps. The components showing intermittent rhythmic delta activity (right and left occipital, right temporal) are framed. The Wechsler Adult Intelligence Scale—Fourth Edition yielded an overall intelligence quotient of 85 (processing speed score of 88, working memory score of 95, perceptual/logical reasoning score of 72, and verbal comprehension score of 100; bottom). FLAIR fluid attenuated inversion recovery, MPRAGE magnetization prepared rapid gradient echo, NPH normal pressure hydrocephalus, SWI susceptibility-weighted imaging | PMC9550762 | 702_2022_2544_Fig1_HTML.jpg |
0.507314 | b3d8663642f4491fbcad4a82cbf599f1 | LB and LRFR induce distinct transcriptional changes in elongating hypocotyls.a Hypocotyl elongation of the indicated genotypes. The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. Different letters indicate significant differences (P < 0.05, two-way ANOVA with Tukey’s HSD test; the exact P values are available in the Source Data). Sample size (n) that is given on top indicates biologically independent seedlings examined over one experiment. The experiment was repeated two times with similar results. b Schematic summary of the experimental setup used for transcriptome analysis. c Number of up- and downregulated genes in Col-0 hypocotyls in the indicated light conditions (FDR < 0.05, T test with BH correction). d GO term enrichment analysis in Col-0 hypocotyl upregulated gene lists. Each node indicates a significantly enriched GO term (FDR < 0.05). Two terms (nodes) are connected if they share 20% or more genes. The line thickness increases with the increasing number of shared genes between two terms. Only selected GO terms (black outlines) are annotated. The full list of enriched GO terms is in Supplementary Data 2, the interactive version of (d) is available at https://figshare.com/s/864fba30bbd3919d0745. See also Supplementary Fig. 1. | PMC9550796 | 41467_2022_33384_Fig1_HTML.jpg |
0.430889 | fd798d52752048569ac9ff42dfd75944 | Most LRFR-induced genes in hypocotyls require both PIFs and YUCs.a The distribution of hypocotyl-induced genes in LRFR according to the dependence on PIFs and YUCs using the comparison of Col-0, pif457, and yuc2589 transcriptomes (FDR < 0.05, F test with post hoc test). b Distributions of Z-scores computed from replicate averages for categories shown in (a). The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. c The distribution of hypocotyl-induced genes according to the dependence on PIFs and YUCs in each of the selected significantly enriched GO terms. Numbers indicate significantly regulated genes in the given categories and/or GO terms. The full list of misregulated genes and enriched GO terms are given in Supplementary Data 3. See also Supplementary Fig. 2. | PMC9550796 | 41467_2022_33384_Fig2_HTML.jpg |
0.428692 | eef3af3ef8754943a571b8219473ab4b | PIFs & YUCs are required for basal expression of many growth- and hormone-associated genes in hypocotyls of WL-grown seedlings.a The distribution of LB-induced genes in hypocotyls according to the dependence on PIFs and YUCs using the comparison of Col-0, pif457, and yuc2589 transcriptomes (FDR < 0.05, F test with post hoc test). b Distributions of Z-scores computed from replicate averages for categories shown in (a). c Number of misregulated genes in pif457 and yuc2589 hypocotyls compared to Col-0 in WL (FDR < 0.05, T test with BH correction). d Distributions of Z-scores computed from replicates averages for genes that are grouped as in (c). e Comparison of PIF-dependent genes in hypocotyls with putative PIF4 targets (as listed in ref. 26), promoters (1 kb upstream) containing G-box (CACGTG) or PBE-box (CATGTG). Asterisks (*) indicate the statistically significant overrepresentation compared to expected (P < 0.05, Binomial distribution, one-tailed; the exact P values are available in the Source Data). b, d The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. Numbers indicate significantly regulated genes in the given categories and/or GO terms. The full list of misregulated genes, enriched GO terms, and enriched motifs are given in Supplementary Data 4, 5, and 6. See also Supplementary Fig. 3. | PMC9550796 | 41467_2022_33384_Fig3_HTML.jpg |
0.438959 | 08eb7a2f817f4facb18537ff6628db5d | SMT2 is required locally for LRFR-induced hypocotyl elongation.a A simplified representation of sterol biosynthesis pathway in Arabidopsis46. b Normalized CPM (counts per million, normalized to Col-0 average in WL) of SMT2 and SMT3 in the indicated genotypes and conditions (data from RNA-seq). c PIF4-HA binding to the promoter of the indicated genes. PIF4-HA enrichment is quantified by qPCR and presented as IP/Input. Control—C, Peak—P. d–f Hypocotyl elongation of the indicated genotypes. d, f The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. b, c Each data point indicates biologically (b) or technically (c) independent samples, the horizontal bar represents the median, whiskers extend to show the data range. e Data are means ± SD with a regression line. Different letters (d, f, two-way ANOVA with Tukey’s HSD test) and asterisks (*) (b, c, Student’s T test, one-tailed) (e, two-way ANOVA) indicate a significant difference (P < 0.05) compared to WL (b) or control (c), and between genotypes in given light condition (e). The exact P values are available in the Source Data. Sample size (n) that is given on top (d, f); e for Col-0; n (WL-Mock) = 21, n (WL-10 µM) = 21, n (LB-Mock) = 26, n (LB-10 µM) = 26; n (LRFR-Mock) = 24, n (LRFR-10 µM) = 24, n (LB + LRFR-Mock) = 25, n (LB + LRFR-10 µM) = 25; for smt2-1; n (WL-Mock) = 12, n (WL-10 µM) = 14, n (LB-Mock) = 20, n (LB-10 µM) = 21, n (LRFR-Mock) = 16, n (LRFR-10 µM) = 18, n (LB + LRFR-Mock) = 24, n (LB + LRFR-10 µM) = 18) indicates biologically independent seedlings examined over one experiment. The experiments were repeated two (e) and three (c, d, f) times with similar results. See also Supplementary Fig. 4. | PMC9550796 | 41467_2022_33384_Fig4_HTML.jpg |
0.535387 | 918ad772ea8b479ea42ba1f4b0ccd104 | Auxin biosynthesis, response, and transport are normal in smt2-1 in LRFR.a LRFR-induction of auxin biosynthetic genes in the indicated genotypes (data from RNA-seq). Each data point indicates biologically independent samples, the horizontal bar represents the median, whiskers extend to show the data range. b Distributions of Z-scores computed from replicates averages for synthetic auxin picloram up- and downregulated genes in hypocotyls of the indicated genotypes (as listed in ref. 55). c Hypocotyl elongation of indicated genotypes with the indicated doses of picloram. Data are means ± SD with a regression line. d, e Quantification (d) and the representative images (e) of the DII-VENUS signal intensity (normalized to mean value of Col-0 in WL) in hypocotyls of the indicated genotypes either kept at WL or transferred to LRFR for 1 h. White bars equal to 100 µm. b, d The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. Different letters (d, two-way ANOVA with Tukey’s HSD test) and asterisks (*) (c, two-way ANOVA) indicate a significant difference (P < 0.05) between genotypes in given light condition (c) and compared to WL (d). The exact P values are available in the Source Data. Sample size (n) that is given on top (d); ((c) For Col-0: n (WL) = 17, 22, 21, 20; n (LRFR) = 19, 22, 17, 22. For smt2-1: n (WL) = 12, 15, 19, 17; n (LRFR) = 13, 18, 17, 17 with an order of Mock, 2 µM, 5 µM, 10 µM respectively) indicates biologically independent seedlings examined over one experiment. The experiments were repeated two (c) and three (d) times with similar results. The full gene list of LRFR-picloram transcriptome comparison is given in Supplementary Data 8. See also Supplementary Fig. 5. | PMC9550796 | 41467_2022_33384_Fig5_HTML.jpg |
0.412131 | 98139cb436424fb98498b4e0c1702535 | LRFR changes the lipid composition in hypocotyls.a Lipid class abundance at the indicated time points is represented as percentage of total detected lipids in B. rapa hypocotyls. Each data point indicates biologically independent samples, horizontal bar represents the median, whiskers extend to show the data range. GPL glycerophospholipids, GDG glycosyldiacylglycerols, TAG triacylglycerols. b, c Quantification (left) and representative images (right) of (b) LDs using BODIPY™ 493/503 and (c) chloroplasts in Col-0 hypocotyls either kept at WL or transferred to LRFR for 30 h. Data is normalized to WL average. White bars are scale bars of 100 µm. b, c The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. a–c Asterisks indicate P values (*<0.1, **<0.05, Student’s T test, one-tailed). The exact P values are available in the Source Data. b, c Sample size (n) that is given on top indicates biologically independent seedlings examined over one experiment. The experiments were repeated three times with similar results. The full list of detected lipid species is given in Supplementary Data 9. See also Supplementary Fig. 6. | PMC9550796 | 41467_2022_33384_Fig6_HTML.jpg |
0.419114 | 1ec7f97d25954b5da71762abdabe4939 | LB induces autophagy.a Distributions of Z-scores computed from replicates averages for genes listed in autophagy GO term in Col-0 seedlings. The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. The full list of genes in the Autophagy GO term is given in Supplementary Data 10. b Representative image of autophagic flux assay using 35 S:GFP-ATG8a (WT), seedlings were grown in the indicated light conditions with or without ConA (0.5 µM). GFP-ATG8a and free GFP levels were detected in total protein extracts with an anti-GFP antibody. c Quantification of GFP-ATG8a and free-GFP bands in autophagic flux assays. Different letters indicate a significant difference (P < 0.05, two-way ANOVA with Tukey’s HSD test; the exact P values are available in the Source Data). d Representative image of cotyledon pavement cells expressing UBQ10:mCherry-ATG8e in the WT background either kept in WL or treated with LB for 8 h in the presence of concanamycin A (ConA, 5 µM). Yellow arrowheads indicate autophagic bodies. White bars equal to 20 µm. The experiment was repeated two times with similar results using 5 to 7 biologically individual seedlings for each condition and the experiment. e Western blot analysis of GFP-ATG8a and free-GFP levels in cotyledons and hypocotyls of dissected WT seedlings treated with 8 h of LB without ConA. f Quantification of free-GFP bands in (e). Asterisks indicate P values (*<0.001, Student’s T test, one-tailed; the exact P values are available in the Source Data). b, e H3 and TUB were used as loading control. The experiment was repeated four times with similar results. c, f Each data point indicates a biologically independent sample (average of two technical replicates for each data point), horizontal bar represents the median, and whiskers extend to show the data range. See also Supplementary Fig. 8. | PMC9550796 | 41467_2022_33384_Fig7_HTML.jpg |
0.425118 | f9a2f848f2e344ba903548bef54ea88a | Hypocotyl elongation phenotypes correlate well with induction of autophagy in response to changing light environments.a Western blot analysis of GFP-ATG8a and free GFP in WT seedlings treated for 8 h with LB or LP without ConA. b Quantification of free-GFP bands in (a). Each data point indicates a biologically independent sample (average of two technical replicates for each data point), horizontal bar represents the median, and whiskers extend to show the data range. c Hypocotyl elongation of WT seedlings treated with LB, LP, or LB with increased PAR (High PAR, HP) compared to WL. d GFP-ATG8a and free-GFP levels are detected in WT seedlings treated with 8 h of LB, LRFR, or LRFR + LB without ConA. e Hypocotyl elongation of seedlings with the indicated genotypes treated with the indicated light conditions. The sample size (n) that is given on top indicates biologically independent seedlings examined over one experiment. The experiments were repeated four (a, d) and three (e) times with similar results. H3 (a, d) and TUB (d) were used as a loading control. c, e The horizontal bar represents the median; boxes extend from the 25th to the 75th percentile, whiskers extend to show the data range. b, c, e Different letters indicate significant difference (P < 0.05, two-way ANOVA with Tukey’s HSD test, the exact P values are available in the Source Data). f Model for hypocotyl elongation in full sunlight, neighbor proximity, and vegetative shade conditions. In full sunlight (left panel) and neighbor proximity (middle panel), plants receive high-intensity blue light (high blue, shown by the color white) and autophagy remains at basal levels. Vegetative shade (right panel) decreases the blue light intensity (low blue, shown by the dark-gray color) and promotes autophagy-mediated recycling. The reduced R/FR ratio in neighbor proximity and vegetative shade inactivates phyB thereby promoting PIF activity. | PMC9550796 | 41467_2022_33384_Fig8_HTML.jpg |
0.38091 | 78cda5180de24e9b97b6959b74d453bb | a SEM images and b corresponding sizes of mTNs prepared at various concentrations of TA (scale bar = 1 μm). ∗Significantly different compared to 0.5 mg/ml of TA (p < 0.05). c Absorbance spectra of mTNs dispersed in DW. d Total phenol content and e calcium content of mTNs prepared with various concentrations of TA. ∗Significantly different compared to 0.5 mg/ml (p < 0.05). f Weight of mTNs prepared at various TA concentrations. ∗Significantly different compared to 0.5 mg/ml (p < 0.05). g XRD patterns of mTNs and commercially available hydroxyapatite. h FT-IR analysis of TA and mTNs | PMC9551158 | 40580_2022_338_Fig1_HTML.jpg |
0.434871 | f189d6deb6e4439ba7a56934e8dd6a5f | a Schematic illustration of supramolecular self-assembly of mTNs. High-resolution b C1s, c O1s, d Ca2p, and e P2p XPS spectra of mTNs prepared using various concentrations of TA | PMC9551158 | 40580_2022_338_Fig2_HTML.jpg |
0.427678 | 89f7a95c570b44e0a9ff054bdbe14c74 | a Live/dead images and b MTT assay results of hADSCs cultured using various concentrations of TA (scale bar = 200 μm). ∗Significantly different compared to the group with no nanoparticles (p < 0.05). c Live/dead images and d MTT assay results of hADSCs cultured using various concentrations of mTNs (scale bar = 200 μm). ∗Significantly different compared to the group with no nanoparticles (p < 0.05) | PMC9551158 | 40580_2022_338_Fig3_HTML.jpg |
0.395208 | 04a7d859f52e446daaa6a9b6f57df300 | a Fe conversion and b ABTS inhibition assay results for various concentrations of mTNs. ∗Significantly different compared to the group treated with no nanoparticles (p < 0.05). c DCF-DA assay images and d quantitative analysis of the fluorescence intensity of hADSCs cultured with or without H2O2 and mTNs (scale bar = 100 μm). *Significantly different compared to the H2O2 (−)/mTN (−) group (p < 0.05) | PMC9551158 | 40580_2022_338_Fig4_HTML.jpg |
0.414053 | fc625c4266314769bbfc11cf13ecf62f | a Schematic illustration of the anti-inflammation activity of mTNs in a mouse peritonitis model and the experimental timeline. ELISA results for (b) IL-6 and (c) TNF-α in the blood. *Significantly different compared to N.C. (p < 0.05). ELISA results for (d) IL-6 and (e) TNF-α in the peritoneal fluid. N.C mice were treated with DW only while the P.C group was treated with zymosan only. *Significantly different compared to the N.C group (p < 0.05) | PMC9551158 | 40580_2022_338_Fig5_HTML.jpg |
0.500402 | 3359c29ba6674c7ea5ac334f7c5f944c | a Alizarin red S staining images of hADSCs cultured with or without mTNs for 14 days (scale bar = 5 mm) and b quantitative analysis. c ALP activity of hADSCs cultured with GM and ODM with or without mTNs for 7 days. *Significantly different compared to GM (p < 0.05). Relative mRNA expression of the osteogenic markers (d) OPN, (e) RUNX2, and (f) OCN in hADSCs cultured in ODM with or without H2O2 and mTNs for 14 days. ∗, ∗ ∗, ∗ ∗ ∗significantly different compared to H2O2 (−)/mTN (−) (∗p < 0.033, ∗ ∗p < 0.002, ∗ ∗ ∗p < 0.001) | PMC9551158 | 40580_2022_338_Fig6_HTML.jpg |
0.486969 | b0067abeee3c4b1da46fe2f72fedccb9 | Schematic illustration of mTN fabrication and multi-functionality of mTNs | PMC9551158 | 40580_2022_338_Sch1_HTML.jpg |
0.443131 | e60b76afdf8e48b9a353dd275a1b4ba6 | Anatomical and histopathologic analysis of forest musk deer lung tissues. (A-C) The clinical-pathological alterations of lung tissues of 3 forest musk deer that died of ARDS. (D) HE staining image of normal lung tissue. Black arrow: alveoli; Red arrow: alveolar wall. (E-G) HE staining images of lung tissues of forest musk deer with ARDS. The black arrow in Fig. 1E-1G represents the pus cells in the alveolar space. The red arrow in Fig. 1E indicates the exudates in the alveolar space. The red arrow in Fig. 1F denotes the alveolar wall capillary congestion. The red arrow in Fig. 1G indicates pulmonary interstitial congestion. The yellow arrow in Fig. 1G indicates a large number of pus cells in the bronchi | PMC9552132 | 12864_2022_8917_Fig1_HTML.jpg |
0.438264 | 45242249121c4256b625faaeb03355ea | Statistical analysis of unigenes. (A) Length distribution patterns ofunigenes. (B) GC content frequency distribution patterns of unigenes | PMC9552132 | 12864_2022_8917_Fig2_HTML.jpg |
0.40553 | 069abc567241416fb3089af17236f885 | Species and functional annotations of unigenes. (A) Species distribution of unigenes annotated by the NR database. (B) GO annotation analysis for unigenes. (C) KEGG annotation analysis for unigenes | PMC9552132 | 12864_2022_8917_Fig3_HTML.jpg |
0.398408 | ed8c21c1b7cf47c8826583f8e02396df | Identification of DEGs and related GO/KEGG enrichment analysis. (A) Heatmap of DEGsin diseased lung tissues of forest musk deer compared to the normal lung tissue group.The R package v3.6.3 and ComplexHeatmapR package v2.2.0 were used to create the heatmap. (B) Top 20 KEGG pathways enriched by DEGs [20] | PMC9552132 | 12864_2022_8917_Fig4_HTML.jpg |
0.459201 | 6156e10fb7c148b1b34c9d2b8c9c977e | Venn analytical outcomes of unigene sets in Tables S6-S10. The upper section shows the Venn diagram of unigenes in Tables S6-S10. The middle histogram presents the number of unigenes in Tables S6-S10.The chart below displays the number of specific (1) elements of one list or shared elements by 2, 3, … lists. For instance, a total of 332 unigenes were specific to one list. In addition, 79 unigenes, 20unigenes, and 1 unigenewere shared by 2, 3, and 4 of the 5 lists, respectively | PMC9552132 | 12864_2022_8917_Fig5_HTML.jpg |
0.462106 | 06fbaf184276411c891849f932002f8e | Descrição da sequência de validação das recomendações para a atenção nutricional na atenção primária à saúde brasileira pela técnica Delphia | PMC9553020 | rpsp-46-e119_Figure1.jpg |
0.519392 | 312fe1e94a7b4364b2d9d1dd73f77aa5 | The transcription of CXC chemokine-VEGFA network in COAD (UALCAN). (a1–m1) The transcription expression of CXCL1/2/3/5/6/8/11/12/13/14/16/17 and VEGFA in COAD based on sample types. (a2–m2) The transcription expression of CXCL1/2/3/5/6/8/11/12/13/14/16/17 and VEGFA in COAD based on the sex of the patient. (a3–m3) The transcription expression of CXCL1/2/3/5/6/8/11/12/13/14/16/17 and VEGFA in COAD based on individual cancer stages. Sample type denotes normal and patient groups. Gender denotes male and female. A Student's t-test was used for the comparative analysis, ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001. | PMC9553499 | BMRI2022-5137301.001.jpg |
0.365248 | 06eb0e346707497fb80868b002f199b2 | The protein expression of CXC chemokine-VEGFA network in COAD (Human Protein Atlas). (a1–h1) The protein expression of CXCL5/8/11/12/13/14/16 and VEGFA in normal colon tissue, respectively. (a2–h2) The protein expression of CXCL5/8/11/12/13/14/16 and VEGFA in COAD tissue, respectively. Note: the Human Protein Atlas database does not include immunohistochemical data for CXCL1/2/3/6/17 in COAD tissue. | PMC9553499 | BMRI2022-5137301.002.jpg |
0.43764 | 03fb0078fd7140c3bd10c0d2f4f42386 | Correlation between the pathological stage and different expressed CXC chemokine-VEGFA network of COAD patients (GEPIA): (a) CXCL9; (b) CXCL10; (c) CXCL11; (d) VEGFA. Notably, our results did not show statistically significant data. A Student's t-test was used for the comparative analysis. | PMC9553499 | BMRI2022-5137301.003.jpg |
0.47046 | 09a32a5b63ab475da10311dcaaad3b21 | The prognostic value of CXC chemokine-VEGFA network in COAD (GEPIA). The overall survival curve of (a) CXCL8 and (b) CXCL14. The disease-free survival of (c) CXCL11 and (d) VEGFA. Note: our results did not show statistically significant data. | PMC9553499 | BMRI2022-5137301.004.jpg |
0.389347 | 783b7f714cf246bcb89834f1b109f81b | Genetic alteration of CXC chemokine-VEGFA network in COAD (cBioPortal). | PMC9553499 | BMRI2022-5137301.005.jpg |
0.569902 | fda7010075d142239145f015d2af69fa | Promoter methylation of CXC chemokine-VEGFA network in COAD (UALCAN). (a) The promoter methylation level of CXCL1 in healthy individuals and COAD patients. (b) The promoter methylation level of CXCL2 in healthy individuals and COAD patients. (c) The promoter methylation level of CXCL3 in healthy individuals and COAD patients. (d) The promoter methylation level of CXCL5 in healthy individuals and COAD patients. (e) The promoter methylation level of CXCL6 in healthy individuals and COAD patients. (f) The promoter methylation level of CXCL11 in healthy individuals and COAD patients. (g) The promoter methylation level of CXCL12 in healthy individuals and COAD patients. (h) The promoter methylation level of CXCL13 in healthy individuals and COAD patients. (i) The promoter methylation level of CXCL14 in healthy individuals and COAD patients. (j) The promoter methylation level of CXCL17 in healthy individuals and COAD patients. (k) The promoter methylation level of VEGFA in healthy individuals and COAD patients. Note: our results did not show statistically significant data. A Student's t-test was used for the comparative analysis, ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001. | PMC9553499 | BMRI2022-5137301.006.jpg |
0.4416 | bb716be91bb84c6aa3f62fe8a99c0b37 | Interaction analyses of CXC chemokine-VEGFA network in COAD. (a) PPI network of CXC chemokine-VEGFA network in COAD (STRING). (b) Network and function analyses of CXC chemokine-VEGFA network in COAD (GeneMANIA). | PMC9553499 | BMRI2022-5137301.007.jpg |
0.430079 | 851ab76633af440fbe7592d3dd9ba0bd | GO function and KEGG pathway enrichment analyses of CXC chemokine-VEGFA network in COAD (Metascape). (a) Biological processes in COAD. (b) Molecular functions in COAD. (c) KEGG pathway analysis in COAD. | PMC9553499 | BMRI2022-5137301.008.jpg |
0.39056 | ea0a8f085adb4789b3eed656b728d592 | Genes differentially expressed in correlation with CXC chemokine-VEGFA network in COAD (LinkedOmics). (a1–m1) Pearson's correlation test was used to analyze correlations between CXCL1/2/3/5/6/8/11/12/13/14/16/17, VEGFA, and genes differentially expressed in COAD, respectively. (a2–m2, a3–m3) Heat maps showing genes positively and negatively correlated with CXCL1/2/3/5/6/8/11/12/13/14/16/17 and VEGFA in COAD, respectively (top 50 genes). | PMC9553499 | BMRI2022-5137301.009.jpg |
0.423489 | edda916005cf4920b911699f883bea17 | Gene expression correlation analysis of CXC chemokine-VEGFA network in COAD (LinkedOmics). The scatter plot shows Pearson's correlation of CXCL1 expression with expression of (a1) CXCL3, (a2) CXCL2, and (a3) ZC3H12A in COAD; Pearson's correlation of CXCL2 expression with expression of (b1) CXCL3, (a2) CXCL1, and (b2) ZC3H12A in COAD; Pearson's correlation of CXCL3 expression with expression of (a1) CXCL1, (b1) CXCL2, and (b3) ZC3H12A in COAD; Pearson's correlation of CXCL5 expression with expression of (c1) IL24, (c2) IL8, and (c3) MMP3 in COAD; Pearson's correlation of CXCL6 expression with expression of (d1) CXCL5, (d2) MMP3, and (d3) IL8 in COAD; Pearson's correlation of CXCL8 expression with expression of (e1) GPR109B, (e2) IL1B, and (e3) OSM in COAD; Pearson's correlation of CXCL11 expression with expression of (f1) CXCL10, (f2) UBD, and (f3) IDO1 in COAD; Pearson's correlation of CXCL12 expression with expression of (g1) NPR1, (g2) SLIT3, and (g3) SHE in COAD; Pearson's correlation of CXCL13 expression with expression of (h1) TIGIT, (h2) SH2D1A, and (h3) SIRPG in COAD; Pearson's correlation of CXCL14 expression with expression of (i1) D4S234E, (i2) TNFSF11, and (i3) COL9A1 in COAD; Pearson's correlation of CXCL16 expression with expression of (j1) ZMYND15, (j2) FLII, and (j3) NDEL1 in COAD; Pearson's correlation of CXCL17 expression with expression of (k1) FAM83A, (k2) GPR110, and (k3) SEMG1 in COAD; and Pearson's correlation of VEGFA expression with expression of (l1) GTPBP2, (l2) CCNL1, and (l3) CREBZF in COAD. | PMC9553499 | BMRI2022-5137301.010.jpg |
0.336689 | e69c441e24944bf783b93379e5d2e261 | The correlation between CXC chemokine-VEGFA network and immune cell infiltration in COAD (TIMER): (a) CXCL1; (b) CXCL2; (c) CXCL3; (d) CXCL5; (e) CXCL6; (f) CXCL8; (g) CXCL11; (h) CXCL12; (i) CXCL13; (j) CXCL14; (k) CXCL16; (l) CXCL17; (m) VEGFA. | PMC9553499 | BMRI2022-5137301.011.jpg |
0.51507 | 4e7325a75c6d4f3abbd3689ac44c475c | Effect of different intervention modes on MC903 plus OVA-induced symptoms of atopic dermatitis in mice. (A) Procedure for two intervention modes. (B) Gross appearances of the ears on day 10 after AD induction. (C) AD severity score, including the number of scratching bouts, erythema/hemorrhage, eruption, edema and scaling-like changes in the ear on a scale of 0–10, with higher scores indicating more severe AD symptoms (n = 12). (D) Ear thickness relative to that of day 0 after MC903 plus OVA induction (n = 12). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AD group (one-way ANOVA test). CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g001.jpg |
0.419863 | e00dd3d99b2441dda1a6c0ac760021ce | Effect of different intervention modes on ear inflammation in mice with atopic dermatitis. (A) Histology of the skin lesions. Hematoxylin and eosin (H&E) staining showed the thickness of the dermis, toluidine blue staining showed the infiltration of mast cells, and Carbol 2R hematoxylin indicated eosinophils. (B) H&E staining shows the thickness of the dermis in 10 random fields of view of mice ear sections. (C) Mast cells are indicated by yellow triangles on the images, and their numbers represent the number of mast cells in 10 random fields of view of mouse ear sections. (D) Eosinophils are the number of cells in 10 random fields of view of mice ear sections. ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AD group (one-way ANOVA test). CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g002.jpg |
0.399302 | 26a1f32d1320426aa342a195ab989d0e | Effects of different intervention modes on the ileal mucosal barrier and histomorphology. (A) Immunohistochemistry showing ZO-1 expression (black arrows) in the ileal mucosa of mice in each group. (B) The expression level of ZO-1 in the ileum (n = 6). (C) Mouse ileal villus height expressed as height in 10 random fields of mouse ear slices. (D) The ratio of ileal villus height to crypt depth. **P < 0.01, ***P < 0.001 vs. CON group; #P < 0.05, ###P < 0.001 vs. AD group (one-way ANOVA test). CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g003.jpg |
0.41179 | deb13205d7514dc998de0d3f5c98b010 | Effect of different intervention modes on regulatory T-cell of spleen of mice with atopic dermatitis induction. (A) Isolated cells were obtained from the spleens of different groups of mice. (B) Based on the spleen cell percentage, CD4+ CD25+ Foxp3+ cells were calculated. A Kruskal-Wallis analysis was performed between all groups (n = 5). **P < 0.01, ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01 vs. AD group. CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g004.jpg |
0.411949 | 9a47ffa40dfe4697afd9d4176792b263 | Cytokine levels in mice plasma and ear tissue. (A) Zonulin, IL-12, IgG1/IgG2a, IL-4, sIgA, IL-10, IgE in plasma and TSLP, IL-33 in ear tissue. *P < 0.05, **P < 0.01, ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AD group (one-way ANOVA test) (n = 5–6). (B) Spearman correlation analysis was performed for cytokines in mice, with red indicating positive correlation and blue indicating negative correlation, with darker colors representing stronger correlation. The right slope of the ellipse represents a negative correlation, and the left slope represents a positive correlation. The flatter the ellipse, the more significant it is. *P < 0.05, **P < 0.01, ***P < 0.001. CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g005.jpg |
0.397063 | 677c372fe6d84c229ec10abc42f85d37 | Effect of different intervention modes on ileal microbiota in AD mice. (A) Alpha diversity is measured by the chao1 index and Shannon index (n = 5). (B) Principal coordinate analysis (PCoA) score plots based on unweighted- UniFrac and weighted-UniFrac distance and permutational multivariate analysis of variance (PERMANOVA) was used to test the difference between groups at the OTU level. (C,D) Mean relative abundance of genus level and species level. (E) Taxa are significantly different between groups based on LEfSe analysis (LDA score > 4). *P < 0.05, **P < 0.01, ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AD group (n = 5). CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g006.jpg |
0.452062 | 258228f9b8de42698994a79c53cc0f30 | (A) Spearman’s correlation coefficients between pro-inflammatory chemokines and cytokines and changes in the relative abundance of individual genera. Positive correlations are shown in red and negative correlations are shown in blue. Darker colors indicate stronger correlations. The False Discovery Rate was used to correct P-values for multiple testing. *P < 0.05, **P < 0.01, ***P < 0.001. (B) Gene prediction of intestinal flora function of mice (n = 5). CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g007.jpg |
0.505041 | 4d1697ce5b504b8994e067b07b9467c7 | (A) The number of PPs (n = 10); (B) CPCoA, (C) Volcano plot, (D) KEGG enrichment scatter diagram of differently expressed genes for transcriptome analysis of PPs of offspring mice (n = 3). Data are shown as mean ± SD and compared by Student’s t-test; ***P < 0.001 vs. CON group; ###P < 0.001 vs. AD group. CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g008.jpg |
0.45617 | 3d4ec40a5da14088868f04685960e704 | (A) KEGG pathway graph of retinol metabolism and PPAR signaling pathway, (B) asthma rendered by Pathview (n = 3), red for activation, green for inhibition. CON, normal control mice supplemented with sanitary saline; AD, supplementation with sanitary saline after weaning of pups before AD induction; DSM17938, supplementation with DSM17938 after weaning of pups before AD induction; LGG, supplementation with LGG after weaning of pups before AD induction; FN041, supplementation with FN041 after weaning of pups before AD induction; MFN041, FN041 supplementation in dams during the late trimester and lactation period and after weaning of pups before AD induction. | PMC9554658 | fnut-09-987400-g009.jpg |
0.49515 | 7f90c5cd17104acd8381e29b7b32e527 | IgG and IgM autoantibody standard curves. IgG and IgM autoantibodies ELISA standard curves used to calculate the anti-hypothalamus antibodies concentrations in human subject serum. In (A) IgG standard curve and in (B) IgM standard curve are presented. Standard deviation (STD) from three independent runs were shown. Linear regression fitting results (continuous line) and 95% confidence bands of the best-fit line (dotted line) are shown | PMC9556421 | 40519_2022_1388_Fig1_HTML.jpg |
0.458202 | 7a58bc8cec654430bcc6a9e59659c9ac | Serum from AN patients show an immune-reaction against hypothalamic cells. Immunofluorescent detection of binding of immunoglobulin G autoantibodies from 22 patients with AN to a primate hypothalamus section at the level of the arcuate nucleus (Pz 1, 2 and 8 are presented of examples of score 3 immunoreactive pattern, and Pz 10 of score 2). As control, 3 out 18 representative sera from healthy control are shown (Ctr1-3 as examples of score 0, and Ctr7 and Crt9 of score 1). The experiment was repeated four times. In the graph, the different reactivity among AN and healthy control is statistical different. The intensity of the fluorescence was determined by two different readers blind to subject characteristics and a scale from 0 to 3 was assigned (0 no reaction, 1 uncertain fluorescence, 2 nuclear fluorescence, 3 fibers and/or nuclear fluorescence). Samples scored positive if a 2 or 3 fluorescence reaction was observed | PMC9556421 | 40519_2022_1388_Fig2_HTML.jpg |
0.500167 | 673d593ba5eb4c6ab5980e6b3027b532 | Anti-hypothalamic antibody IgG levels are present in sera from AN patients. A measurable anti-hypothalamic IgG antibody level is present exclusively in AN patients (Panel A). The amount of anti-hypothalamic IgG antibody correlates positively with the intensity of fluorescence on hypothalamus section (Panel B) | PMC9556421 | 40519_2022_1388_Fig3_HTML.jpg |
0.481398 | f2c631a56aa84d2f8e17d4c9a8c47402 | Orexigenic and anorexigenic molecules evaluation. A comparison of plasma ghrelin, POMC, AGRP and leptin levels in women with AN and healthy control women are shown | PMC9556421 | 40519_2022_1388_Fig4_HTML.jpg |
0.444284 | a44c8af9b13742eb99f5547b02a8d216 | Correlation analysis among the amount of orexigenic and anorexigenic molecules was performed | PMC9556421 | 40519_2022_1388_Fig5_HTML.jpg |
0.487333 | 9273241df50c4d1e8d46878748c55c59 | Correlation analysis among the amount of orexigenic and anorexigenic molecules and anti-hypothalamic antibodies evaluated by immunofluorescence (left panels) and ELISA (right panels) | PMC9556421 | 40519_2022_1388_Fig6_HTML.jpg |
0.472289 | c55c97a80f504ed08f41b4805b846ab0 | Analysis of the correlation among ghrelin, POMC, ARGP, leptin, and fluorescent intensity (IFI) with BMI | PMC9556421 | 40519_2022_1388_Fig7_HTML.jpg |
0.45262 | faf14bfb951847bb8673bfac36ddb844 | Orexigenic and anorexigenic molecules are able to interfere with autoantibodies binding. As orexigenic and anorexigenic molecules are thought to play prominent roles in integration of peripheral and central signals to modulate appetite and metabolism, experiments were set up to investigate whether they may interfere with the binding of reactive autoantibodies to hypothalamic tissues. All 22 AN sera were titred alone and in presence of recombinant human soluble molecules of ghrelin, POMC, AGRP, and α-MSH | PMC9556421 | 40519_2022_1388_Fig8_HTML.jpg |
0.399588 | 787eadfe1d19458ea780247c38726500 | Under the actions of ACSL4, LPACT3 and ALOX15, PUFAs on the cell membrane form PE-PUFA-OOH. Under excessive iron conditions, some iron is stored in the form of ferritin, and the remaining free Fe2+ generates numerous ROS and hydroxyl radicals through the Fenton reaction, which induces ferroptosis on the cell membrane. However, GPX4 reduces PE-PUFA-OOH to -OH and inhibits ferroptosis via the effect of GSH. The synthesis of GSH is mainly regulated by the Xc–system, through which cystine transported into cells is reduced to cysteine to synthesize GSH. p53 can inhibit SLC7A11 expression in this system and promote ferroptosis. In addition, NRF2 can affect the expression of SLC7A11 against ferroptosis. NCOA4-mediated ferritinophagy leads to ferritin production by providing labile iron, deferoxamine can also inhibit ferroptosis by chelating active iron. PUFAs, Polyunsaturated fatty acids; GPX4, Glutathione peroxidase 4; GSH, Reduced glutathione; GSSH, Oxidized glutathione; ACSL4, Acyl-CoA synthetase long-chain family member 4; LPACT3, Lysophosphatidylcholine Acyltransferase 3; ALOX15, Arachidonic acid 15-lipoxygenase; NCOA4, Nuclear receptor coactivator-4; ROS, Reactive oxygen species; TFR1, Transferrin receptor 1; NRF2, Nuclear factor erythroid-related factor 2; DFO, Deferoxamine; STEAP3, six-transmembrane epithelial antigen of the prostate 3. | PMC9556825 | fendo-13-945976-g001.jpg |
0.382136 | 4eb331cde7844a078083885aab5e49db | Study design. Treatment failure is defined as not attaining the ACR50 response on two consecutive study visits (interval of 4 weeks), starting from week 16. ACR, American College of Rheumatology; CASPAR, Classification Criteria for Psoriatic Arthritis; csDMARD, conventional synthetic disease-modifying antirheumatic drug; 18F-FDG PET/CT, fluorine-18-fluorodeoxyglucose positron emission tomography/CT; NR, non-responder to conventional synthetic and a maximum of one biological DMARD therapy. | PMC9557317 | bmjopen-2022-064338f01.jpg |
0.4503 | d3e33f533d7c4fd5a62b7eca49f487dc | Flow chart of patients included in the study. | PMC9558004 | fnagi-14-985406-g0001.jpg |
0.471692 | 8b1e5dbfca5345178b14a6d527faf9a7 | Receiver operating characteristic (ROC) curve analysis of preoperative measurement values of Aβ-42 for postoperative neurocognitive dysfunction (PND). | PMC9558004 | fnagi-14-985406-g0002.jpg |
0.44666 | b0595b946bfc4ac38cf63ac3f9af98ab | Comparison of SctO2 at different time points between group PND and group non-PND. *p < 0.05. | PMC9558004 | fnagi-14-985406-g0003.jpg |
0.439424 | 06da2cecf097499494f706db19a24231 | ROC curve analysis of PND predicted by the maximum percentage decline of SctO2 at each time point. | PMC9558004 | fnagi-14-985406-g0004.jpg |
0.494834 | 464829e722594ab49747a0a2aa48498d | ROC curve analysis of PND predicted by the maximum percentage decline of SctO2 in males at each time point. | PMC9558004 | fnagi-14-985406-g0005.jpg |
0.467758 | 2957838227324826802167be6caa9226 | ROC curve analysis of PND predicted by the maximum percentage decline of SctO2 in females at each time point. | PMC9558004 | fnagi-14-985406-g0006.jpg |
0.529018 | c8f4261bcac14fca8a8ed9ee9a240a85 | Average (calculated) amount of damage (a) and design errors (b) per one barn and each zone, including: lying area (LA), milking area (MA), social area (SA) and feeding area (FA), for barns with tie-stall and freestall housing system. | PMC9559522 | animals-12-02530-g001.jpg |
0.435009 | e3b421b0d04046a89f3708dcc3e2885d | Percentage distribution of damage and construction errors in visited barns with tie-stall and freestall housing system. | PMC9559522 | animals-12-02530-g002.jpg |
0.393899 | 21b819ac515d4f3099eff8e358f5b036 | OCT image showing the method for measuring the central 1-mm subfoveal choroidal thickness. The fovea, outer border of the retinal pigment epithelium, and outer edge of the choroidal vasculature (choroidal–scleral junction) were identified using the Duke Optical Coherence Tomography Retinal Analysis Program Marking Code Baby version 2.0 and were confirmed by trained graders. Choroidal thickness was measured across the central 1 mm centered at the fovea and averaged. | PMC9559969 | gr1.jpg |
0.433472 | c30ac3e558a2461da0c65d82f2a8d8e0 | Histogram showing distribution of choroidal thicknesses for all infants with illustrative OCT images for the thinnest (left), average (center), and thickest (right) choroids in the data set. The asterisks denote the fovea and the white lines denote the choroidal thickness. SFCT = average central 1-mm subfoveal choroidal thickness. | PMC9559969 | gr2.jpg |
0.459528 | ce1ae9f4066b4e1691d0081694527e16 | A–D, Scatterplots representing the relationship between continuous variables (birth weight, gestational age, growth velocity, number of days receiving supplemental oxygen) and average 1-mm subfoveal choroidal thickness. E, Box-and-whisker plots illustrating the relationship between the presence of systemic categorical variables and average 1-mm subfoveal choroidal thickness in infants with each condition. ∗P < 0.05 in the univariate analysis. ∗∗P < 0.005 in the univariate analysis. BPD = bronchopulmonary dysplasia; EPO = erythropoietin administration; ICH,PVL = intracranial hemorrhage, periventricular leukomalacia, or ventriculomegaly; NEC = necrotizing enterocolitis; Oxygen OCT = required oxygen supplementation at the time of OCT imaging; Oxygen 36 Weeks = required oxygen supplementation at 36 weeks’ postmenstrual age; PDA = patent ductus arteriosus; PIE = pulmonary interstitial emphysema; RBC = transfusion of packed red blood cells. | PMC9559969 | gr3.jpg |
0.396163 | 3d8f38cd10594f3aab6d578ebf31d092 | A case of a 5-year-old boy with actinic lichen planus. (A) Melasma-like dark brown patches on the malar area, macules on the upper lip, and papular lesions on the back of hands. (B) Histopathological appearance of a skin biopsy showing hyperkeratosis, hypergranulosis, and lichenoid infiltration at the dermoepidermal junction in the epidermis (H&E, ×100). | PMC9561304 | ad-34-370-g001.jpg |
0.410754 | fe616b06c1894722af11404edf4ca0dd | A case of a 11-year-old boy with actinic lichen planus. (A) Dark brown patches on the right forehead and upper lip, papular lesions on the back of hands. (B) Histopathological appearance of a skin biopsy showing parakeratotic epidermis under hyperkeratosis, and interface dermatitis at the dermoepidermal junction (H&E, ×100). | PMC9561304 | ad-34-370-g002.jpg |
0.48726 | 2702aeadf2b949b4b4e077d1b13dfd2f | A case of a 43-year-old male with actinic lichen planus. (A) Papular lesions with scaling on the back of hands. (B) Histopathological appearance of a skin biopsy showing exocytosis in the acanthotic and spongiotic epidermis, and serosity on the surface (H&E, ×100). | PMC9561304 | ad-34-370-g003.jpg |
0.475192 | fa5c941d2c9f49feac8c943181f97cbe | The pedigree of the family history. | PMC9561304 | ad-34-370-g004.jpg |
0.487118 | d31ba7845eb14404aefa1d6779ccbc6f | The Pareto chart for PBD shows the positive and negative factors affecting A. niger EM77 exochitinase production, Incubation was at 30 °C for 6 days at 200 rpm. | PMC9561733 | gr1.jpg |
0.449003 | 3b7eca62af2645ce9b1c5b32c1ea8c3f | Three-dimensional (3D) response surface graphs illustrating the relationship between chitinase production and experimental levels of each variable, production was at 30 °C for 6 days at 200 rpm. | PMC9561733 | gr2.jpg |
0.424355 | f51e8a47b21d4feba7c2a0a5f8e02bda | (A–E) Different physicochemical, kinetic, and thermodynamic properties of A. niger EM77 chitinase, these figs are derived from the temperature study where the assay was done using (PNPβ—GlcNAc) as a substrate, acetate buffer; pH 5.0 for 30 min at different temperatures. | PMC9561733 | gr3.jpg |
0.385496 | 6818a9af3200437d9d04aace2b8e928f | Effect of the Moso bamboo invasion on species composition difference of each layer among the three forest types [Moso bamboo forest (MB), transition tree-Moso-bamboo forest (TF), and secondary coniferous and broad-leaved mixed forest (SF)] in (A) arborous, (B) shrub, (C) herbaceous layers, and (D) the compound layers with all arborous, shrub, herbaceous species. Significant differences examined with PerMANOVA (permutational multivariate ANOVA) are indicated by P < 0.05 or 0.01. PCoA means principal co-ordinates analysis. PCoA1 and PCoA2 in the figures represented two components of PCoA with largest explaining power to the variation of the species composition difference. | PMC9562732 | fpls-13-1001785-g001.jpg |
0.47151 | 2f30ea5cc1b94561a246b32bec4b6d6d | Effect of the Moso bamboo invasion on species diversity of each layer. Different letters in the same column indicate significant differences at P < 0.05. | PMC9562732 | fpls-13-1001785-g002.jpg |
0.441014 | 7ea40e492b824028af0ee1ac236a75eb | Schematic and simplified depiction of STAT3 pathway activation. Orange diamonds present ligands’ molecules, and black circles marked with “P” present phosphate group. Figure presents the process of receptor dimerization due to their activation by ligands, JAK transphosphorylation, receptors’ phosphorylation, STAT3 phosphorylation, STAT3 dimerization, translocation to the nucleus, and, finally, its binding to DNA. | PMC9563420 | cells-11-03024-g001.jpg |
0.432439 | 2e8338a3219f415c81c0be5e8e628640 | Schematic and simplified depiction of selected pathways and factors regulating STAT3 expression, counting its downstream target proteins, with the consequences of their overexpression in prostate cancer. Dashed lines ending with a dot show inhibition; arrows show stimulation. | PMC9563420 | cells-11-03024-g002.jpg |
0.448814 | 37063e480f8c4270af03100521373fcc | Schematic and simplified depiction of selected pathways and factors regulating STAT3 expression, counting its downstream target proteins, with the consequences of their overexpression in bladder cancer. Dashed lines ending with a dot show inhibition; arrows show stimulation. | PMC9563420 | cells-11-03024-g003.jpg |
0.446529 | 9e351e6e6730437ca8f31c4f907da1e9 | Schematic and simplified depiction of selected pathways and factors regulating STAT3 expression, counting its downstream target proteins, with the consequences of their overexpression in renal cell carcinoma. Dashed lines ending with a dot show inhibition; arrows show stimulation. | PMC9563420 | cells-11-03024-g004.jpg |
0.481978 | f588926e6024409bb216d92a6afd89fd | Clinical characteristics, cell death, and mitochondrial gene expression. Correlation between late apoptosis and (A) plasma anti-SARS-CoV-2 antibody concentration, (B) duration of symptoms of donors, and (C) severity of symptoms (from 0 to 3, 3 being the most severe) was assessed. The time from the onset of symptoms to donation was then correlated with the expression of (D) NDUFA9 and (E) UQCRC2 mRNA expressed by HCAECs. Data are represented as a relative percentage to cells treated with control plasma. Significance was determined by Spearman correlation. p ≤ 0.05 was considered significant. PI: propidium iodide; RBD: receptor binding domain; O.D.: optical density NDUFA9: NADH dehydrogenase 1 alpha subcomplex subunit 9; UQCRC2: cytochrome b-c1 complex subunit 2. | PMC9563445 | cells-11-03122-g001.jpg |
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