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We began to collect our sources.
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With every step, we realized that we were still not doing enough.
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Nowadays, we try to read as many primary sources as possible, talk to multiple experts and document our simplifications, and give further reading in our sources doc.
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But this doesn't make our process flawless.
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What do you do if experts disagree with each other?
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What do you do if you find an amazing fact that perfectly fits a narrative, but just can't find its primary source?
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How do you deal with the reality that many scientific results have huge error bars or maybes attached to them?
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How do you handle complex systems that defy easy answers?
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In the end, we make 10-minute videos, and we need to make decisions about what details and explanations can fit, which aspects need to be simplified, and which parts to cut.
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There is no single best answer for how to do this, and so we weigh the different options every single time.
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It can be painful for experts to see their field simplified, some are happy with us, while others don't like it.
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This is fair, but also impossible to avoid.
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We're still trying to improve and want to be transparent about what we're trying to do.
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For example, we're taking part in the Treska project about science communication to learn more.
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All of this brings us to the purpose of our videos.
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The most important thing we want to do with this channel is to inspire you and spark your curiosity for science and the amazing universe we live in.
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Learning often doesn't feel like fun, but with the right story it is one of the best things, and we hope to provide that to you.
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Ultimately, we hope that we light a fire in you that motivates you to read books, pay more attention at school or university, and just get interested in a scientific field or two and learn more on your own.
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Not because you have to, but because you want to know more about how the world really works.
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Because the universe is beautiful, and science is a way of seeing this beauty more clearly.
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And we hope that knowing that we have to simplify a bit does not make you enjoy our videos less.
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We are trying to build something with Kurzgesagt, and while we're not 100% sure yet what exactly,
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And of course how big things are, and what happens when we blow stuff up, because it's fun.
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We really can't do this without you.
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Running a science communication business is a balancing act that we take extremely seriously.
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On the one hand we need to be responsible and look out for the team and be able to grow responsibly.
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On the other hand we have to protect the integrity of our videos.
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You are enabling us to stay independent, because while we do things like sponsorships or commercial work, the majority of our income comes directly from you, the birbs.
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Kurzgesagt is fundamentally funded by its community, by you.
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Because of you, Kurzgesagt is able to invest as much time in our videos and try to become better.
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You get our calendar every year, support us on Patreon and get your personal birds, watch our videos without adblock or with YouTube premium.
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Our favourite way to keep the channel running are our sciency products from our shop, that hopefully add additional value to the world.
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We love bringing little pieces of knowledge into your home or classroom, that inspire you to learn more about the universe in a little more detail.
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Our latest one teaches you about the night sky and showcases the stars in our night sky and their special significance for humanity.
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With every purchase you directly support what we do on this channel.
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Please don't feel obligated to do so though.
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Watching and sharing is already helping us out a lot and we are just grateful that so many of you care about what we try to do here.
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Thank you so, so much!
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Every second of your life you are under attack.
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Billions of bacteria, viruses and fungi are trying to make you their home.
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So our bodies have developed a super complex little army with guards, soldiers, intelligence, weapons factories and communicators to protect you from, well, dying.
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For this video, let's assume the immune system has 12 different jobs.
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For example, kill enemies, communicate, etc.
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And it has 21 different cells and 2 protein forces.
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These cells have up to 4 different jobs.
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Let's assign them.
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Here are the interactions.
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Now, let's make this understandable.
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First of all, let's add colors to the jobs.
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Now let's illustrate the cells.
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The central color represents the main job of the cell, while the surrounding ones represent secondary duties.
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Now the immune system looks like this.
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Isn't this complexity just awesome?
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For this video, we will only talk about these cells and ignore the rest.
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So what happens in the case of an infection?
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It's a beautiful day when suddenly a wild rusty nail appears and you cut yourself.
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The first barrier of the immune system is breached, your skin.
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Nearby bacteria seize on the opportunity and enter your wound.
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They start using up the body's resources and double their numbers about every 20 minutes.
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At first, they fly under the radar, but when a certain bacteria population is reached, they change their behavior and start to damage the body by changing the environment around them.
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The immune system has to stop them as fast as possible.
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First of all, your guard cells, known as macrophages, intervene.
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They are huge cells that guard every border region of the body.
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Most of the time, they alone can suffocate an attack because they can devour up to 100 intruders each.
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They swallow the intruder whole and trap it inside a membrane.
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Then the enemy gets broken down by enzymes and is killed.
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On top of that, they cause inflammation by ordering the blood vessels to release water into the battlefield, so fighting becomes easier.
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You notice this as a very mild swelling.
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When the macrophages fight for too long, they call in heavy backup by releasing messenger proteins that communicate location and urgency.
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Neutrophiles leave their patrol routes in the blood and move to the battlefield.
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The neutrophiles fight so furiously that they kill healthy cells in the process.
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On top of that, they generate barriers that trap and kill the bacteria.
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They are indeed so deadly that they evolved to commit suicide after 5 days to prevent them from causing too much damage.
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If this is not enough to stop the invasion, the brain of the immune system kicks in.
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The dendritic cell gets active.
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It reacts to the signals of the soldiers and starts collecting samples from the enemies.
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They rip them into pieces and present the parts on their outer layer.
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Now, the dendritic cell makes a crucial decision.
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Should they call for antivirus forces that eradicate infected body cells or an army of bacteria killers?
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In this case, antibacteria forces are necessary.
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It then travels to the closest lymph node in about a day.
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Here, billions of helper and killer T-cells are waiting to be activated.
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When T-cells are born, they go through a difficult and complicated training process and only a quarter survives.
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The surviving cells are equipped with a specific setup.
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And the dendritic cell is on its way, looking for a helper T-cell with a setup that's just right.
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It's looking for a helper T-cell that can bind to the parts of the intruders which the dendritic cell has presented on its membrane.
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When it finally finds one, a chain reaction takes place.
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The helper T-cell is activated.
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It quickly duplicates thousands of times.
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Some become memory T-cells that stay in the lymph node and will make you practically immune against this enemy.
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Some travel to the field of battle to help out.
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And the third group goes on to travel to the center of the lymph node to activate a very powerful weapons factory.
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Like the T-cells, they are born with a specific setup.
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And when a B-cell and a T-cell with the same setup meet, hell breaks loose.
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The B-cell duplicates rapidly and starts producing millions of little weapons.
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They work so hard that they would literally die from exhaustion very fast.
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Here, helper T-cells play another important role.
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They stimulate the hard-working factories and tell them, don't die yet, we still need you, keep going.
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This also ensures that the factories die if the infection is over so the body doesn't waste energy or hurt itself.
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But what is produced by the B-cells?
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