tokens: The changes in renal prostaglandin synthesis were accompanied by evidence of renal damage in aspirin - treated jj but not jJ rats as evidenced by : increased incidence and severity of hematuria ( p less than 0 . 01 ) ; increased serum creatinine ( p less than 0 . 05 ) ; and increase in outer medullary histopathologic lesions ( p less than 0 . 005 compared to either sham - treated jj or aspirin - treated jJ ) .