diff --git "a/PLOD-CW-25-Test.conll" "b/PLOD-CW-25-Test.conll"
new file mode 100644--- /dev/null
+++ "b/PLOD-CW-25-Test.conll"
@@ -0,0 +1,10507 @@
+Within ADP O
+amoebae NOUN O
+and CCONJ O
+macrophages NOUN O
+, PUNCT O
+L. PROPN O
+pneumophila PROPN O
+replicates VERB O
+with ADP O
+a DET O
+similar ADJ O
+mechanism NOUN O
+by ADP O
+forming VERB O
+a DET O
+membrane NOUN O
+- PUNCT O
+bound VERB O
+compartment NOUN O
+, PUNCT O
+the DET O
+Legionella PROPN O
+- PUNCT O
+containing VERB O
+vacuole NOUN O
+( PUNCT O
+LCV PROPN B-AC
+) PUNCT O
+. PUNCT O
+Formation NOUN O
+of ADP O
+the DET O
+LCV PROPN B-AC
+is AUX O
+not PART O
+well ADV O
+defined VERB O
+, PUNCT O
+but CCONJ O
+requires VERB O
+that SCONJ O
+L. PROPN O
+pneumophila PROPN O
+injects VERB O
+proteins NOUN O
+into ADP O
+the DET O
+host NOUN O
+cell NOUN O
+via ADP O
+the DET O
+intracellular ADJ B-LF
+multiplication NOUN I-LF
+( PUNCT O
+Icm)/defective ADJ B-LF
+organelle NOUN I-LF
+trafficking NOUN I-LF
+( PUNCT O
+Dot NOUN B-AC
+) PUNCT O
+secretion NOUN O
+system NOUN O
+. PUNCT O
+
+L NOUN O
+16 NUM O
+: PUNCT O
+Would AUX O
+contraceptive ADJ B-LF
+prevalence NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+CPR NOUN B-AC
+) PUNCT O
+or CCONJ O
+even ADV O
+modern ADJ O
+CPR NOUN B-AC
+( PUNCT O
+mCPR NOUN O
+) PUNCT O
+be AUX O
+more ADV O
+appropriate ADJ O
+? PUNCT O
+
+Stable ADJ O
+metabolically ADV B-LF
+unhealthy ADJ I-LF
+overweight NOUN I-LF
+or CCONJ I-LF
+obesity NOUN I-LF
+( PUNCT O
+MUOO PROPN B-AC
+) PUNCT O
+( PUNCT O
+HR NOUN B-AC
+2.22 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+2.00–2.47 NUM O
+, PUNCT O
+p NOUN O
+< ADP O
+0.001 NUM O
+) PUNCT O
+and CCONJ O
+transition NOUN O
+from ADP O
+metabolically ADV O
+healthy ADJ O
+to ADP O
+unhealthy ADJ O
+status NOUN O
+( PUNCT O
+HR NOUN B-AC
+1.53 NUM O
+, PUNCT O
+1.34–1.75 NUM O
+, PUNCT O
+p NOUN O
+< ADP O
+0.001 NUM O
+) PUNCT O
+were AUX O
+associated VERB O
+with ADP O
+higher ADJ O
+risk NOUN O
+for ADP O
+MVE PROPN B-AC
+, PUNCT O
+compared VERB O
+with ADP O
+stable ADJ O
+healthy ADJ O
+normal ADJ O
+weight NOUN O
+. PUNCT O
+
+At ADP O
+present NOUN O
+, PUNCT O
+many ADJ O
+disease NOUN O
+- PUNCT O
+surveillance NOUN O
+systems NOUN O
+rely VERB O
+either CCONJ O
+on ADP O
+comparing VERB O
+current ADJ O
+counts NOUN O
+with ADP O
+historical ADJ O
+time NOUN O
+- PUNCT O
+series NOUN O
+models NOUN O
+, PUNCT O
+or CCONJ O
+on ADP O
+identifying VERB O
+sudden ADJ O
+increases NOUN O
+in ADP O
+utilization NOUN O
+( PUNCT O
+e.g. X O
+, PUNCT O
+cumulative ADJ B-LF
+sum NOUN I-LF
+[ X O
+CUSUM X B-AC
+] PUNCT O
+or CCONJ O
+exponential ADJ B-LF
+weighted VERB I-LF
+moving VERB I-LF
+average NOUN I-LF
+[ X O
+EWMA PROPN B-AC
+] PUNCT O
+[ X O
+9,10 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Also ADV O
+see VERB O
+Fig PROPN O
+4 NUM O
+. PUNCT O
+dpIns1 NOUN O
+, PUNCT O
+dorsal ADJ O
+posterior ADJ O
+insula NOUN O
+cluster NOUN O
+1 NUM O
+; PUNCT O
+PO1 NOUN B-AC
+, PUNCT O
+parietal ADJ B-LF
+operculum NOUN I-LF
+cluster NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+STG1 NOUN O
+, PUNCT O
+superior ADJ O
+temporal ADJ O
+gyrus NOUN O
+cluster NOUN O
+1 NUM O
+. PUNCT O
+
+In ADP O
+C. PROPN O
+elegans NOUN O
+, PUNCT O
+the DET O
+prevailing VERB O
+response NOUN O
+to ADP O
+mitochondrial ADJ O
+stress NOUN O
+is AUX O
+the DET O
+mitochondrial ADJ B-LF
+unfolded VERB I-LF
+protein NOUN I-LF
+response NOUN I-LF
+( PUNCT O
+UPRmt NOUN B-AC
+) PUNCT O
+[ X O
+16–19 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+principal ADJ O
+catabolic ADJ O
+fate NOUN O
+of ADP O
+cholesterol NOUN O
+is AUX O
+its PRON O
+conversion NOUN O
+to ADP O
+the DET O
+primary ADJ O
+bile NOUN B-LF
+acids NOUN I-LF
+( PUNCT O
+BAs PROPN B-AC
+) PUNCT O
+, PUNCT O
+cholic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+CA PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+chenodeoxycholic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+CDCA NOUN B-AC
+) PUNCT O
+through ADP O
+BBB NOUN B-AC
+- PUNCT O
+permeable ADJ O
+intermediate ADJ O
+metabolites NOUN O
+called VERB O
+oxysterols NOUN O
+( PUNCT O
+S1 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+performed VERB O
+one NUM O
+- ADJ O
+way NOUN O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+( PUNCT O
+ANOVA NOUN B-AC
+) PUNCT O
+with ADP O
+Tukey PROPN O
+'s PART O
+HSD NOUN O
+post ADJ O
+- ADJ O
+hoc ADJ O
+test VERB O
+to PART O
+test VERB O
+the DET O
+significance NOUN O
+in ADP O
+comparisons NOUN O
+with ADP O
+more ADJ O
+than ADP O
+2 NUM O
+groups NOUN O
+. PUNCT O
+
+The DET O
+types NOUN O
+of ADP O
+variability NOUN O
+responsiveness NOUN O
+tested VERB O
+were AUX O
+SL PROPN B-AC
+variability NOUN O
+and CCONJ O
+MTC PROPN B-AC
+variability NOUN O
+using VERB O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD PROPN B-AC
+) PUNCT O
+and CCONJ O
+CV NOUN B-AC
+, PUNCT O
+and CCONJ O
+SBS PROPN B-AC
+- PUNCT B-AC
+FTA NOUN B-AC
+variability NOUN O
+. PUNCT O
+
+We PRON O
+then ADV O
+investigated VERB O
+the DET O
+DIP2A PROPN B-AC
+expression NOUN O
+pattern NOUN O
+in ADP O
+the DET O
+adult ADJ O
+cortex NOUN O
+with ADP O
+Dip2a NOUN B-LF
+- NOUN I-LF
+β NOUN I-LF
+- NOUN I-LF
+galactosidase NOUN I-LF
+( PUNCT O
+LacZ PROPN B-AC
+) PUNCT O
+mice NOUN O
+, PUNCT O
+in ADP O
+which PRON O
+LacZ PROPN B-AC
+was AUX O
+designed VERB O
+with ADP O
+nucleus NOUN O
+expression NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+47 NUM O
+- PUNCT O
+item NOUN O
+PMH PROPN B-AC
+instrument NOUN O
+consists VERB O
+of ADP O
+six NUM O
+domains NOUN O
+of ADP O
+mental ADJ O
+health NOUN O
+; PUNCT O
+general ADJ B-LF
+coping NOUN I-LF
+( PUNCT O
+GC PROPN B-AC
+, PUNCT O
+9 NUM O
+items NOUN O
+) PUNCT O
+, PUNCT O
+emotional ADJ B-LF
+support NOUN I-LF
+( PUNCT O
+ES PROPN B-AC
+, PUNCT O
+7 NUM O
+items NOUN O
+) PUNCT O
+, PUNCT O
+spirituality NOUN O
+( PUNCT O
+7 NUM O
+items NOUN O
+) PUNCT O
+, PUNCT O
+interpersonal ADJ B-LF
+skills NOUN I-LF
+( PUNCT O
+IS PROPN B-AC
+, PUNCT O
+9 NUM O
+items NOUN O
+) PUNCT O
+, PUNCT O
+personal ADJ B-LF
+growth NOUN I-LF
+and CCONJ I-LF
+autonomy NOUN I-LF
+( PUNCT O
+PGA PROPN B-AC
+, PUNCT O
+10 NUM O
+items NOUN O
+) PUNCT O
+and CCONJ O
+global ADJ B-LF
+affect NOUN I-LF
+( PUNCT O
+GA PROPN B-AC
+, PUNCT O
+5 NUM O
+items NOUN O
+) PUNCT O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+Preliminary ADJ O
+results NOUN O
+show VERB O
+that SCONJ O
+a DET O
+tax NOUN O
+levied VERB O
+on ADP O
+sugar NOUN B-LF
+- PUNCT I-LF
+sweetened VERB I-LF
+beverages NOUN I-LF
+( PUNCT O
+SSBs PROPN B-AC
+) PUNCT O
+by ADP O
+the DET O
+Portuguese ADJ O
+government NOUN O
+in ADP O
+2017 NUM O
+led VERB O
+to ADP O
+a DET O
+drop NOUN O
+in ADP O
+sales NOUN O
+and CCONJ O
+reformulation NOUN O
+of ADP O
+these DET O
+products NOUN O
+. PUNCT O
+
+TB NOUN B-AC
+, PUNCT O
+tuberculosis NOUN B-LF
+; PUNCT O
+TST NOUN B-AC
+, PUNCT O
+tuberculin NOUN B-LF
+skin NOUN I-LF
+testing NOUN I-LF
+. PUNCT O
+
+LOS PROPN B-AC
+= PUNCT O
+late ADJ O
+onset NOUN O
+sepsis NOUN O
+, PUNCT O
+NEC PROPN B-AC
+= PUNCT O
+necrotizing VERB B-LF
+enterocolitis NOUN I-LF
+
+The DET O
+data NOUN O
+of ADP O
+the DET O
+ENMERE-2016 PROPN B-AC
+( PUNCT O
+Peruvian PROPN B-LF
+Medical PROPN I-LF
+Residents PROPN I-LF
+National PROPN I-LF
+Survey-2016 PROPN I-LF
+) PUNCT O
+belongs VERB O
+to ADP O
+the DET O
+National PROPN O
+Committee PROPN O
+of ADP O
+Peruvian PROPN O
+Medical PROPN O
+Residency PROPN O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to PART O
+understand VERB O
+how SCONJ O
+p84 NOUN O
+could AUX O
+mask VERB O
+Ser582 PROPN O
+phosphorylation NOUN O
+, PUNCT O
+and CCONJ O
+to PART O
+map VERB O
+the DET O
+p110γ NOUN O
+- PUNCT O
+p84 NOUN O
+contact NOUN O
+interface NOUN O
+, PUNCT O
+hydrogen NOUN B-LF
+deuterium NOUN I-LF
+exchange NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT O
+HDX NOUN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+. PUNCT O
+
+FPG PROPN B-AC
+, PUNCT O
+fasting VERB B-LF
+plasma NOUN I-LF
+glucose NOUN I-LF
+; PUNCT O
+TNFi PROPN B-AC
+, PUNCT O
+tumour NOUN O
+necrosis NOUN O
+factor NOUN O
+inhibitor NOUN O
+. PUNCT O
+
+Among ADP O
+HNSCCs PROPN O
+, PUNCT O
+oral ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinomas NOUN I-LF
+( PUNCT O
+OSCCs PROPN B-AC
+) PUNCT O
+include VERB O
+several ADJ O
+anatomical ADJ O
+locations NOUN O
+of ADP O
+the DET O
+oral ADJ O
+cavity NOUN O
+, PUNCT O
+but CCONJ O
+exclude VERB O
+the DET O
+oropharynx NOUN O
+. PUNCT O
+
+We PRON O
+then ADV O
+did VERB O
+the DET O
+reverse ADJ O
+experiment NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+we PRON O
+coexpressed VERB O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+STAT1 PROPN O
+and CCONJ O
+mutant ADJ O
+STAT2 PROPN O
+that PRON O
+harbored VERB O
+alanine NOUN O
+in ADP O
+the DET O
+STAT1 PROPN O
+F77 PROPN O
+homologous ADJ O
+position NOUN O
+leucine NOUN O
+82 NUM O
+( PUNCT O
+Fig PROPN O
+1B NOUN O
+, PUNCT O
+panels NOUN O
+11 NUM O
+and CCONJ O
+12 NUM O
+) PUNCT O
+or CCONJ O
+the DET O
+functionally ADV O
+equivalent ADJ O
+double ADJ O
+mutation NOUN O
+LL81,82AA NUM O
+( PUNCT O
+S3 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+finding NOUN O
+of ADP O
+an DET O
+overall ADJ O
+rise NOUN O
+in ADP O
+opioid NOUN O
+prescribing NOUN O
+is AUX O
+complementary ADJ O
+to ADP O
+a DET O
+recent ADJ O
+study NOUN O
+using VERB O
+National PROPN B-LF
+Health PROPN I-LF
+Service PROPN I-LF
+( PUNCT O
+NHS PROPN B-AC
+) PUNCT O
+digital ADJ O
+pharmacy NOUN O
+claims NOUN O
+data NOUN O
+demonstrating VERB O
+a DET O
+34 NUM O
+% NOUN O
+increase NOUN O
+in ADP O
+opioid NOUN O
+prescriptions NOUN O
+between ADP O
+1998 NUM O
+and CCONJ O
+2016 NUM O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+most ADJ O
+patients NOUN O
+, PUNCT O
+preoperative ADJ O
+levels NOUN O
+of ADP O
+serum ADJ O
+follicle NOUN B-LF
+- PUNCT I-LF
+stimulating VERB I-LF
+hormone NOUN I-LF
+( PUNCT O
+FSH PROPN B-AC
+) PUNCT O
+, PUNCT O
+leutenizing VERB B-LF
+hormone NOUN I-LF
+( PUNCT O
+LH PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+total ADJ O
+testosterone NOUN O
+were AUX O
+measured VERB O
+. PUNCT O
+
+Lgl PROPN B-AC
+binds VERB O
+to PART O
+atypical ADJ B-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+C PROPN I-LF
+( PUNCT O
+aPKC PROPN B-AC
+) PUNCT O
+and CCONJ O
+Par6 PROPN O
+, PUNCT O
+and CCONJ O
+this DET O
+interaction NOUN O
+has AUX O
+been AUX O
+shown VERB O
+to PART O
+regulate VERB O
+the DET O
+function NOUN O
+of ADP O
+Lgl PROPN B-AC
+in ADP O
+cell NOUN O
+polarity NOUN O
+[ PUNCT O
+14],[15],[16 NUM O
+] PUNCT O
+. PUNCT O
+
+IPTp PROPN B-AC
+- PUNCT O
+SP PROPN B-AC
+has AUX O
+been AUX O
+shown VERB O
+to PART O
+reduce VERB O
+low ADJ B-LF
+birth NOUN I-LF
+weight NOUN I-LF
+( PUNCT O
+LBW PROPN B-AC
+) PUNCT O
+deliveries NOUN O
+and CCONJ O
+maternal ADJ O
+morbidity NOUN O
+[ PUNCT O
+1],[9 NUM O
+] PUNCT O
+. PUNCT O
+
+A NOUN O
+) PUNCT O
+When SCONJ O
+compared VERB O
+to ADP O
+their PRON O
+control NOUN O
+( PUNCT O
+CypD+/+ PROPN B-AC
+) PUNCT O
+littermates NOUN O
+, PUNCT O
+BMSCs NOUN B-AC
+from ADP O
+CypD-/- PROPN B-AC
+mice NOUN O
+have VERB O
+higher ADJ O
+oxidative ADJ O
+metabolism NOUN O
+measured VERB O
+with ADP O
+both CCONJ O
+CMXRos PROPN O
+( PUNCT O
+A NOUN O
+) PUNCT O
+and CCONJ O
+via ADP O
+oxygen NOUN B-LF
+consumption NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+OCR PROPN B-AC
+) PUNCT O
+assay NOUN O
+using VERB O
+Seahorse PROPN O
+XF PROPN O
+technology NOUN O
+( PUNCT O
+B NOUN O
+) PUNCT O
+; PUNCT O
+C X O
+) PUNCT O
+X NOUN O
+- ADJ O
+ray NOUN O
+and CCONJ O
+micro ADJ B-AC
+- ADJ B-AC
+CT ADJ B-AC
+images NOUN O
+of ADP O
+spinal ADJ O
+grafts NOUN O
+at ADP O
+D0 NOUN O
+and CCONJ O
+at ADP O
+12 NUM O
+wks NOUN O
+post ADJ O
+- ADJ O
+surgery NOUN O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+oxylipins NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+prostaglandins NOUN O
+, PUNCT O
+including VERB O
+prostaglandin NOUN B-LF
+E2 PROPN I-LF
+( PUNCT O
+PGE2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+leukotrienes NOUN O
+play VERB O
+a DET O
+pivotal ADJ O
+role NOUN O
+in ADP O
+the DET O
+inflammatory ADJ O
+response NOUN O
+[ PUNCT O
+12,13 NUM O
+] PUNCT O
+. PUNCT O
+
+By ADP O
+searching VERB O
+a DET O
+database NOUN O
+of ADP O
+pathogen NOUN O
+proteins NOUN O
+, PUNCT O
+the DET O
+researchers NOUN O
+discovered VERB O
+that SCONJ O
+rotavirus NOUN O
+protein NOUN O
+VP-7 NOUN O
+contains VERB O
+a DET O
+very ADV O
+similar ADJ O
+peptide NOUN O
+; PUNCT O
+a DET O
+search NOUN O
+of ADP O
+a DET O
+database NOUN O
+of ADP O
+human ADJ O
+proteins NOUN O
+indicated VERB O
+that SCONJ O
+celiac ADJ O
+peptide NOUN O
+also ADV O
+resembles VERB O
+peptides NOUN O
+found VERB O
+in ADP O
+tissue NOUN O
+transglutaminase NOUN O
+, PUNCT O
+Toll PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+4 NUM I-LF
+( PUNCT O
+TLR4 PROPN B-AC
+; PUNCT O
+a DET O
+protein NOUN O
+involved VERB O
+in ADP O
+the DET O
+innate ADJ O
+immune ADJ O
+response NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+several ADJ O
+other ADJ O
+self NOUN O
+- PUNCT O
+antigens NOUN O
+. PUNCT O
+
+Confocal ADJ O
+microscopy NOUN O
+analysis NOUN O
+of ADP O
+adoptively ADV O
+transferred VERB O
+TCR PROPN O
+- NOUN O
+transgenic ADJ O
+CD8 PROPN O
++ NOUN O
+T PROPN O
+cells NOUN O
+( PUNCT O
+Spiky PROPN O
+) PUNCT O
+in ADP O
+LNs PROPN B-AC
+performed VERB O
+on ADP O
+day NOUN O
+2 NUM O
+post NOUN O
+immunization NOUN O
+with ADP O
+DC PROPN B-AC
+- NOUN O
+targeting VERB O
+viral ADJ O
+particles NOUN O
+. PUNCT O
+( PUNCT O
+E NOUN O
+) PUNCT O
+Zoom VERB O
+- NOUN O
+in ADP O
+panels NOUN O
+of ADP O
+the DET O
+area NOUN O
+indicated VERB O
+by ADP O
+rectangle NOUN O
+in ADP O
+( PUNCT O
+D NOUN O
+) PUNCT O
+. PUNCT O
+Scale NOUN O
+bars NOUN O
+represent VERB O
+30 NUM O
+μm NOUN O
+( PUNCT O
+D NOUN O
+) PUNCT O
+and CCONJ O
+10 NUM O
+μm NOUN O
+( PUNCT O
+E NOUN O
+) PUNCT O
+. PUNCT O
+Data NOUN O
+represent VERB O
+mean ADJ O
+± ADJ O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean ADJ I-LF
+( PUNCT O
+SEM PROPN B-AC
+) PUNCT O
+for ADP O
+6–20 NUM O
+mice NOUN O
+per ADP O
+group NOUN O
+from ADP O
+three NUM O
+independent ADJ O
+experiments NOUN O
+( PUNCT O
+A NOUN O
+– PUNCT O
+B NOUN O
+) PUNCT O
+. PUNCT O
+Data NOUN O
+represent VERB O
+mean ADJ O
+± ADJ O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD NOUN B-AC
+) PUNCT O
+for ADP O
+5–10 NUM O
+datasets NOUN O
+from ADP O
+2–3 NUM O
+mice NOUN O
+per ADP O
+group NOUN O
+from ADP O
+two NUM O
+independent ADJ O
+experiments NOUN O
+( PUNCT O
+C NOUN O
+) PUNCT O
+. PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.05 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.01 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.001 NUM O
+( PUNCT O
+one NUM O
+- NOUN O
+way NOUN O
+ANOVA NOUN O
+with ADP O
+Tukey PROPN O
+’s PART O
+post NOUN O
+- NOUN O
+test NOUN O
+[ X O
+A NOUN O
+– PUNCT O
+B NOUN O
+] PUNCT O
+or CCONJ O
+Kruskal PROPN O
+- NOUN O
+Wallis PROPN O
+test NOUN O
+with ADP O
+Dunn PROPN O
+’s PART O
+post NOUN O
+- NOUN O
+test NOUN O
+[ X O
+C NOUN O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+ns NOUN O
+, PUNCT O
+not PART O
+significant ADJ O
+. PUNCT O
+
+The DET O
+neurotoxin NOUN O
+6 NUM B-AC
+- PUNCT B-AC
+OHDA NOUN B-AC
+is AUX O
+selectively ADV O
+transported VERB O
+via ADP O
+the DET O
+dopamine NOUN B-LF
+transporter NOUN I-LF
+( PUNCT O
+DAT PROPN B-AC
+) PUNCT O
+. PUNCT O
+We PRON O
+compared VERB O
+toxicity NOUN O
+of ADP O
+6 NUM B-AC
+- PUNCT B-AC
+OHDA NOUN B-AC
+in ADP O
+purified ADJ O
+and CCONJ O
+unpurified ADJ O
+N27 PROPN O
+cells NOUN O
+. PUNCT O
+
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+BD NOUN B-AC
+, PUNCT O
+birth NOUN B-LF
+defect NOUN I-LF
+. PUNCT O
+
+We PRON O
+compared VERB O
+the DET O
+tumor NOUN O
+cells NOUN O
+and CCONJ O
+the DET O
+patient NOUN O
+'s PART O
+peripheral ADJ O
+blood NOUN O
+cells NOUN O
+by ADP O
+fluorescent ADJ O
+in ADP O
+situ NOUN O
+hybridization NOUN O
+using VERB O
+X NOUN O
+and CCONJ O
+Y NOUN O
+chromosome NOUN O
+probes NOUN O
+, PUNCT O
+by ADP O
+PCR NOUN O
+for ADP O
+the DET O
+amelogenin NOUN O
+gene NOUN O
+X- NOUN O
+and CCONJ O
+Y NOUN O
+- PUNCT O
+specific ADJ O
+alleles NOUN O
+, PUNCT O
+by ADP O
+MassArray PROPN O
+for ADP O
+the DET O
+ATM PROPN O
+patient NOUN O
+specific ADJ O
+mutation NOUN O
+and CCONJ O
+for ADP O
+several ADJ O
+SNPs NOUN O
+, PUNCT O
+by ADP O
+PCR NOUN O
+for ADP O
+polymorphic ADJ O
+microsatellites NOUN O
+, PUNCT O
+and CCONJ O
+by ADP O
+human ADJ B-LF
+leukocyte NOUN I-LF
+antigen NOUN I-LF
+( PUNCT O
+HLA PROPN B-AC
+) PUNCT O
+typing NOUN O
+. PUNCT O
+
+The DET O
+Area PROPN B-LF
+Under ADP I-LF
+the DET I-LF
+Curve PROPN I-LF
+( PUNCT O
+AUC PROPN B-AC
+) PUNCT O
+, PUNCT O
+sensitivity NOUN O
+, PUNCT O
+specificity NOUN O
+, PUNCT O
+along ADP O
+with ADP O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV NOUN B-AC
+) PUNCT O
+and CCONJ O
+negative ADJ O
+predicting VERB O
+value NOUN O
+( PUNCT O
+NPV NOUN B-AC
+) PUNCT O
+and CCONJ O
+p NOUN O
+value NOUN O
+were AUX O
+determined VERB O
+. PUNCT O
+
+For ADP O
+Ontario PROPN O
+residents NOUN O
+with ADP O
+diagnosed VERB O
+OSA PROPN B-AC
+, PUNCT O
+funding NOUN O
+is AUX O
+provided VERB O
+for ADP O
+continuous ADJ B-LF
+positive ADJ I-LF
+airway NOUN I-LF
+pressure NOUN I-LF
+( PUNCT O
+CPAP PROPN B-AC
+) PUNCT O
+devices NOUN O
+, PUNCT O
+and CCONJ O
+this DET O
+funding NOUN O
+is AUX O
+documented VERB O
+in ADP O
+the DET O
+Assistive PROPN B-LF
+Devices PROPN I-LF
+Program PROPN I-LF
+( PUNCT O
+ADP PROPN B-AC
+) PUNCT O
+database NOUN O
+from ADP O
+2004 NUM O
+onwards ADV O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+There PRON O
+are VERB O
+two NUM O
+genome NOUN O
+- PUNCT O
+wide ADJ O
+approaches NOUN O
+to PART O
+identify VERB O
+novel ADJ O
+imprinted VERB O
+genes NOUN O
+in ADP O
+mammals NOUN O
+: PUNCT O
+quantification NOUN O
+of ADP O
+parent NOUN B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+origin NOUN I-LF
+differential ADJ I-LF
+allelic ADJ I-LF
+expression NOUN I-LF
+( PUNCT O
+pDAE PROPN B-AC
+) PUNCT O
+to PART O
+identify VERB O
+monoallelic ADJ O
+expression NOUN O
+directly ADV O
+from ADP O
+the DET O
+transcripts NOUN O
+, PUNCT O
+or CCONJ O
+identification NOUN O
+of ADP O
+parent NOUN B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+origin NOUN I-LF
+dependent ADJ I-LF
+differentially ADV I-LF
+methylated VERB I-LF
+regions NOUN I-LF
+( PUNCT O
+pDMRs PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+genome NOUN O
+. PUNCT O
+
+Based VERB O
+on ADP O
+these DET O
+data NOUN O
+, PUNCT O
+we PRON O
+estimated VERB O
+instantaneous ADJ B-LF
+carboxylation NOUN I-LF
+efficiency NOUN I-LF
+( PUNCT O
+PN NOUN B-AC
+/ SYM B-AC
+Ci NOUN B-AC
+) PUNCT O
+and CCONJ O
+instantaneous ADJ B-LF
+water NOUN I-LF
+use NOUN I-LF
+efficiency NOUN I-LF
+( PUNCT O
+WUE NOUN B-AC
+, PUNCT O
+( PUNCT O
+μmol NOUN O
+m-2 NOUN O
+s-1)/(mmol NOUN O
+H2O NOUN O
+m-2 NOUN O
+s-1 NOUN O
+) PUNCT O
+) PUNCT O
+, PUNCT O
+as ADP O
+the DET O
+ratio NOUN O
+PN NOUN B-AC
+/ SYM O
+E NOUN O
+[ PUNCT O
+28 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+reduction NOUN O
+in ADP O
+the DET O
+rate NOUN O
+of ADP O
+YLL PROPN B-AC
+calculated VERB O
+based VERB O
+on ADP O
+the DET O
+age NOUN O
+- PUNCT O
+standardized VERB O
+deaths NOUN O
+shows VERB O
+that SCONJ O
+most ADJ O
+causes NOUN O
+of ADP O
+death NOUN O
+have AUX O
+registered VERB O
+a DET O
+fall NOUN O
+in ADP O
+rate NOUN O
+of ADP O
+years NOUN B-LF
+of ADP I-LF
+life NOUN I-LF
+lost VERB I-LF
+from ADP O
+1990 NUM O
+to ADP O
+2015 NUM O
+. PUNCT O
+
+Outcomes NOUN O
+: PUNCT O
+acid NOUN B-LF
+- PUNCT I-LF
+fast ADJ I-LF
+bacilli NOUN I-LF
+( PUNCT O
+AFB PROPN B-AC
+) PUNCT O
+smear NOUN O
+microscopy NOUN O
+( PUNCT O
+smear NOUN O
+) PUNCT O
+and CCONJ O
+culture NOUN O
+conversion NOUN O
+, PUNCT O
+adverse ADJ O
+events NOUN O
+, PUNCT O
+and CCONJ O
+WHO PROPN B-AC
+- PUNCT O
+defined VERB O
+treatment NOUN O
+outcomes NOUN O
+, PUNCT O
+including VERB O
+cure NOUN O
+, PUNCT O
+treatment NOUN O
+completion NOUN O
+, PUNCT O
+treatment NOUN O
+failure NOUN O
+, PUNCT O
+loss NOUN O
+to PART O
+follow VERB O
+- PUNCT O
+up ADP O
+, PUNCT O
+not PART O
+evaluated VERB O
+, PUNCT O
+and CCONJ O
+death NOUN O
+( PUNCT O
+see VERB O
+Table NOUN O
+1 NUM O
+for ADP O
+definitions NOUN O
+) PUNCT O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+Acute ADJ O
+cellular ADJ O
+rejection NOUN O
+and CCONJ O
+interstitial ADJ B-LF
+fibrosis NOUN I-LF
+and CCONJ I-LF
+tubular ADJ I-LF
+atrophy NOUN I-LF
+( PUNCT O
+IF NOUN B-AC
+/ SYM B-AC
+TA NOUN B-AC
+) PUNCT O
+index NOUN O
+were AUX O
+graded VERB O
+according VERB O
+to ADP O
+the DET O
+Banff’13 PROPN O
+criteria NOUN O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+MHN PROPN B-AC
+, PUNCT O
+metabolically ADV B-LF
+healthy ADJ I-LF
+normal ADJ I-LF
+weight NOUN I-LF
+; PUNCT O
+MHOO PROPN B-AC
+, PUNCT O
+metabolically ADV B-LF
+healthy ADJ I-LF
+overweight NOUN I-LF
+or CCONJ I-LF
+obesity NOUN I-LF
+; PUNCT O
+MUN PROPN B-AC
+, PUNCT O
+metabolically ADV B-LF
+unhealthy ADJ I-LF
+normal ADJ I-LF
+weight NOUN I-LF
+; PUNCT O
+MUOO PROPN B-AC
+, PUNCT O
+metabolically ADV B-LF
+unhealthy ADJ I-LF
+overweight NOUN I-LF
+or CCONJ I-LF
+obesity NOUN I-LF
+. PUNCT O
+
+CC PROPN B-AC
+, PUNCT O
+corpus NOUN B-LF
+callosum NOUN I-LF
+; PUNCT O
+DTI PROPN B-AC
+, PUNCT O
+diffusion NOUN B-LF
+tensor NOUN I-LF
+imaging NOUN I-LF
+; PUNCT O
+EC PROPN B-AC
+, PUNCT O
+external ADJ B-LF
+capsule NOUN I-LF
+; PUNCT O
+EM PROPN B-AC
+, PUNCT O
+electron NOUN B-LF
+microscopy NOUN I-LF
+; PUNCT O
+IL-4 NOUN B-AC
+, PUNCT O
+interleukin-4 NOUN B-LF
+; PUNCT O
+LSD PROPN B-AC
+, PUNCT O
+least ADJ B-LF
+significant ADJ I-LF
+difference NOUN I-LF
+; PUNCT O
+MCAO PROPN B-AC
+, PUNCT O
+middle ADJ B-LF
+cerebral ADJ I-LF
+artery NOUN I-LF
+occlusion NOUN I-LF
+. PUNCT O
+
+Each DET O
+record NOUN O
+in ADP O
+the DET O
+census NOUN O
+data NOUN O
+had VERB O
+information NOUN O
+on ADP O
+the DET O
+census NOUN O
+enumeration NOUN B-LF
+area NOUN I-LF
+( PUNCT O
+EA PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+smallest ADJ O
+geographical ADJ O
+unit NOUN O
+, PUNCT O
+with ADP O
+an DET O
+average ADJ O
+population NOUN O
+of ADP O
+750 NUM O
+. PUNCT O
+
+MT NOUN O
+, PUNCT O
+microtubule NOUN O
+; PUNCT O
+PIV PROPN B-AC
+, PUNCT O
+particle NOUN B-LF
+image NOUN I-LF
+velocimetry NOUN I-LF
+. PUNCT O
+
+The DET O
+following ADJ O
+variables NOUN O
+were AUX O
+available ADJ O
+for ADP O
+analysis NOUN O
+: PUNCT O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+ethnicity NOUN O
+( PUNCT O
+white ADJ O
+, PUNCT O
+black ADJ O
+, PUNCT O
+South ADJ O
+Asian ADJ O
+, PUNCT O
+or CCONJ O
+other ADJ O
+) PUNCT O
+, PUNCT O
+smoking NOUN O
+status NOUN O
+( PUNCT O
+current ADJ O
+smoker NOUN O
+, PUNCT O
+previous ADJ O
+smoker NOUN O
+, PUNCT O
+never ADV O
+smoked VERB O
+) PUNCT O
+, PUNCT O
+co NOUN O
+- PUNCT O
+morbidities NOUN O
+( PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+[ PUNCT O
+DM PROPN B-AC
+] PUNCT O
+, PUNCT O
+ischaemic ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+[ PUNCT O
+IHD PROPN B-AC
+] PUNCT O
+, PUNCT O
+cerebrovascular ADJ O
+disease NOUN O
+, PUNCT O
+peripheral ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+[ PUNCT O
+PAD PROPN B-AC
+] PUNCT O
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+[ PUNCT O
+COPD PROPN B-AC
+] PUNCT O
+, PUNCT O
+and CCONJ O
+malignancy NOUN O
+) PUNCT O
+, PUNCT O
+cause NOUN O
+of ADP O
+CKD PROPN B-AC
+( PUNCT O
+vascular ADJ O
+, PUNCT O
+diabetes NOUN O
+, PUNCT O
+glomerular ADJ O
+, PUNCT O
+tubulointerstitial ADJ O
+, PUNCT O
+cystic ADJ O
+or CCONJ O
+congenital ADJ O
+, PUNCT O
+or CCONJ O
+other ADJ O
+or CCONJ O
+unknown ADJ O
+) PUNCT O
+, PUNCT O
+mean ADJ B-LF
+arterial ADJ I-LF
+pressure NOUN I-LF
+( PUNCT O
+MAP PROPN B-AC
+) PUNCT O
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+eGFR PROPN B-AC
+, PUNCT O
+calculated VERB O
+using VERB O
+the DET O
+4 NUM O
+- PUNCT O
+variable NOUN O
+Modification PROPN O
+of ADP O
+Diet PROPN O
+in ADP O
+Renal PROPN O
+Disease PROPN O
+formula NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+urine NOUN O
+albumin NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+creatinine NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+ACR PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Following VERB O
+this DET O
+further ADJ O
+simplification NOUN O
+we PRON O
+obtain VERB O
+a DET O
+new ADJ O
+death NOUN O
+model NOUN O
+, PUNCT O
+with ADP O
+only ADV O
+three NUM O
+coefficients NOUN O
+to PART O
+estimate:(13)Finally VERB O
+, PUNCT O
+because SCONJ O
+the DET O
+values NOUN O
+of ADP O
+, PUNCT O
+, PUNCT O
+and CCONJ O
+Ra NOUN O
+come VERB O
+with ADP O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+, PUNCT O
+we PRON O
+need VERB O
+to PART O
+account VERB O
+for ADP O
+this DET O
+uncertainty NOUN O
+when SCONJ O
+computing VERB O
+CFRs NOUN B-AC
+. PUNCT O
+For ADP O
+each DET O
+age NOUN O
+group NOUN O
+a DET O
+, PUNCT O
+we PRON O
+proceed VERB O
+as ADP O
+follows VERB O
+. PUNCT O
+( PUNCT O
+1 X O
+) PUNCT O
+We PRON O
+generate VERB O
+K NOUN O
+= SYM O
+1,000 NUM O
+sample NOUN O
+datasets NOUN O
+, PUNCT O
+where SCONJ O
+and CCONJ O
+are AUX O
+sampled VERB O
+from ADP O
+a DET O
+normal ADJ O
+distribution NOUN O
+with ADP O
+the DET O
+same ADJ O
+mean NOUN O
+and CCONJ O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+as ADP O
+in ADP O
+Tables NOUN O
+S2 NUM O
+and CCONJ O
+S3 NOUN O
+of ADP O
+Text NOUN O
+S1 NOUN O
+, PUNCT O
+whereas SCONJ O
+values NOUN O
+are AUX O
+obtained VERB O
+by ADP O
+running VERB O
+our PRON O
+model NOUN O
+parameters NOUN O
+sampled VERB O
+from ADP O
+the DET O
+joint ADJ O
+posterior ADJ O
+distribution NOUN O
+of ADP O
+our PRON O
+MCMC PROPN B-AC
+analysis NOUN O
+. PUNCT O
+( PUNCT O
+2 X O
+) PUNCT O
+We PRON O
+fit VERB O
+the DET O
+death NOUN O
+model NOUN O
+for ADP O
+each DET O
+replicate NOUN O
+k NOUN O
+by ADP O
+maximum NOUN O
+likelihood NOUN O
+using VERB O
+the DET O
+function NOUN O
+glm.nb NOUN O
+of ADP O
+R NOUN O
+2.15.1 NUM O
+[ PUNCT O
+35 NUM O
+] PUNCT O
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+screened VERB O
+for ADP O
+new ADJ O
+sporulation NOUN O
+genes NOUN O
+using VERB O
+a DET O
+transposon NOUN B-LF
+- NOUN I-LF
+sequencing VERB I-LF
+( PUNCT O
+Tn PROPN B-AC
+- NOUN B-AC
+seq NOUN B-AC
+) PUNCT O
+approach NOUN O
+[ PUNCT O
+28 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+white ADJ O
+asterisks NOUN O
+represent VERB O
+the DET O
+CF PROPN B-AC
+located VERB O
+at ADP O
+1 NUM O
+and CCONJ O
+21 NUM O
+kHz NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+( PUNCT O
+B NOUN O
+) PUNCT O
+Figure NOUN O
+shows VERB O
+the DET O
+color NOUN O
+- PUNCT O
+coded VERB O
+locations NOUN O
+of ADP O
+the DET O
+recording VERB O
+sites NOUN O
+within ADP O
+the DET O
+schematic ADJ O
+representation NOUN O
+of ADP O
+the DET O
+parcellation NOUN O
+of ADP O
+the DET O
+auditory ADJ O
+cortex NOUN O
+[ PUNCT O
+( PUNCT O
+AAF PROPN O
+( PUNCT O
+anterior ADJ O
+auditory ADJ O
+field NOUN O
+) PUNCT O
+, PUNCT O
+AI PROPN B-AC
+( PUNCT O
+primary ADJ B-LF
+auditory ADJ I-LF
+cortex NOUN I-LF
+) PUNCT O
+, PUNCT O
+D PROPN O
+( PUNCT O
+dorsal ADJ O
+field NOUN O
+) PUNCT O
+, PUNCT O
+DP PROPN O
+( PUNCT O
+dorsoposterior ADJ O
+field NOUN O
+) PUNCT O
+, PUNCT O
+V NOUN O
+( PUNCT O
+ventral ADJ O
+field NOUN O
+) PUNCT O
+, PUNCT O
+VP PROPN O
+( PUNCT O
+ventroposterior ADJ O
+field NOUN O
+) PUNCT O
+] PUNCT O
+. PUNCT O
+
+Essential ADJ O
+data NOUN O
+are AUX O
+available ADJ O
+on ADP O
+https://git.io/JTg1l X O
+. PUNCT O
+a.u NOUN O
+. PUNCT O
+, PUNCT O
+arbitrary ADJ O
+units NOUN O
+; PUNCT O
+GD PROPN B-AC
+, PUNCT O
+geodesic ADJ B-LF
+distance NOUN I-LF
+; PUNCT O
+MPC NOUN B-AC
+, PUNCT O
+microstructure NOUN B-LF
+profile NOUN I-LF
+covariance NOUN I-LF
+; PUNCT O
+TS PROPN O
+, PUNCT O
+tractography NOUN O
+strength NOUN O
+. PUNCT O
+
+Plasma NOUN O
+levels NOUN O
+of ADP O
+NAD+ NOUN O
+and CCONJ O
+its PRON O
+metabolites NOUN O
+[ X O
+NADP+ NOUN O
+, PUNCT O
+cyclic ADJ B-LF
+ADP NOUN I-LF
+ribose NOUN I-LF
+( PUNCT O
+cADPR PROPN B-AC
+) PUNCT O
+, PUNCT O
+nicotinamide NOUN B-LF
+( PUNCT O
+NAM PROPN B-AC
+) PUNCT O
+, PUNCT O
+N NOUN B-LF
+- NOUN I-LF
+methylnicotinamide NOUN I-LF
+( PUNCT O
+MeNAM NOUN B-AC
+) PUNCT O
+] PUNCT O
+were AUX O
+measured VERB O
+by ADP O
+liquid NOUN O
+chromatography NOUN O
+coupled VERB O
+to ADP O
+tandem ADJ O
+mass NOUN O
+spectrometry NOUN O
+( PUNCT O
+LC NOUN O
+/ SYM O
+MS PROPN O
+/ SYM O
+MS PROPN O
+) PUNCT O
+, PUNCT O
+as SCONJ O
+previously ADV O
+described VERB O
+[ X O
+25 NUM O
+] PUNCT O
+. PUNCT O
+
+As SCONJ O
+ART PROPN B-AC
+coverage NOUN O
+increases NOUN O
+from ADP O
+10 NUM O
+% PUNCT O
+to ADP O
+97 NUM O
+% PUNCT O
+of ADP O
+eligible ADJ O
+employees NOUN O
+, PUNCT O
+increases NOUN O
+in ADP O
+survival NOUN O
+and CCONJ O
+retention NOUN O
+of ADP O
+HIV PROPN O
+- PUNCT O
+positive ADJ O
+employees NOUN O
+and CCONJ O
+associated VERB O
+reductions NOUN O
+in ADP O
+absenteeism NOUN O
+and CCONJ O
+benefit NOUN O
+payments NOUN O
+lead VERB O
+to ADP O
+cost NOUN O
+savings NOUN O
+compared VERB O
+to ADP O
+a DET O
+scenario NOUN O
+of ADP O
+no DET O
+treatment NOUN O
+provision NOUN O
+, PUNCT O
+with ADP O
+the DET O
+annual ADJ O
+cost NOUN O
+of ADP O
+HIV PROPN O
+to ADP O
+the DET O
+company NOUN O
+decreasing VERB O
+by ADP O
+5 NUM O
+% PUNCT O
+( PUNCT O
+90 NUM O
+% PUNCT O
+credibility NOUN B-LF
+interval NOUN I-LF
+[ X O
+CrI NOUN B-AC
+] X O
+2%–8 NUM O
+% PUNCT O
+) PUNCT O
+and CCONJ O
+the DET O
+mean ADJ O
+cost NOUN O
+per ADP O
+HIV PROPN O
+- PUNCT O
+positive ADJ O
+employee NOUN O
+decreasing VERB O
+by ADP O
+14 NUM O
+% PUNCT O
+( PUNCT O
+90 NUM O
+% PUNCT O
+CrI NOUN B-AC
+7%–19 NUM O
+% PUNCT O
+) PUNCT O
+by ADP O
+2022 NUM O
+. PUNCT O
+
+We PRON O
+used VERB O
+data NOUN O
+from ADP O
+14,633 NUM O
+singleton ADJ O
+live ADJ O
+birth NOUN O
+pregnancies NOUN O
+from ADP O
+women NOUN O
+participating VERB O
+in ADP O
+13 NUM O
+studies NOUN O
+conducted VERB O
+from ADP O
+1996 NUM O
+to ADP O
+2015 NUM O
+in ADP O
+8 NUM O
+African ADJ O
+countries NOUN O
+and CCONJ O
+the DET O
+Western PROPN O
+Pacific PROPN O
+( PUNCT O
+PNG PROPN B-AC
+) PUNCT O
+as ADP O
+part NOUN O
+of ADP O
+the DET O
+Maternal PROPN B-LF
+Malaria PROPN I-LF
+and CCONJ I-LF
+Malnutrition PROPN I-LF
+( PUNCT O
+M3 PROPN B-AC
+) PUNCT O
+initiative NOUN O
+[ X O
+9,11,13–24 NUM O
+] PUNCT O
+. PUNCT O
+
+Participants NOUN O
+were AUX O
+randomly ADV O
+allocated VERB O
+in ADP O
+a DET O
+1∶1 NUM O
+ratio NOUN O
+to ADP O
+induction NOUN B-LF
+of ADP I-LF
+labor NOUN I-LF
+( PUNCT O
+IoL PROPN B-AC
+) PUNCT O
+or CCONJ O
+expectant ADJ B-LF
+management NOUN I-LF
+( PUNCT O
+EM PROPN B-AC
+) PUNCT O
+using VERB O
+block NOUN O
+randomization NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+Body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+BW PROPN B-AC
+, PUNCT O
+Birthweight NOUN B-LF
+. PUNCT O
+
+Expression NOUN O
+of ADP O
+steroid NOUN B-LF
+5α NOUN I-LF
+- NOUN I-LF
+reductase NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+SRD5A2 NOUN B-AC
+) PUNCT O
+was AUX O
+only ADV O
+consistently ADV O
+detectable ADJ O
+in ADP O
+the DET O
+genital ADJ O
+tubercle NOUN O
+. PUNCT O
+
+Our PRON O
+primary ADJ O
+MR NOUN B-AC
+analysis NOUN O
+method NOUN O
+was AUX O
+inverse ADJ B-LF
+variance NOUN I-LF
+weighted VERB I-LF
+( PUNCT O
+IVW PROPN B-AC
+) PUNCT O
+regression NOUN O
+where SCONJ O
+at ADV O
+least ADV O
+two NUM O
+exposure NOUN O
+SNPs NOUN B-AC
+were AUX O
+available ADJ O
+for ADP O
+analysis NOUN O
+. PUNCT O
+
+CKIP-1 PROPN O
+, PUNCT O
+casein NOUN O
+kinase NOUN O
+interacting VERB O
+protein NOUN O
+1 NUM O
+; PUNCT O
+H2B PROPN B-AC
+, PUNCT O
+histone NOUN B-LF
+2B NUM I-LF
+; PUNCT O
+HH PROPN B-AC
+, PUNCT O
+Hamburger PROPN B-LF
+- PUNCT I-LF
+Hamilton PROPN I-LF
+stage NOUN I-LF
+; PUNCT O
+pSmad1/5/8 NUM B-AC
+, PUNCT O
+phospho NOUN O
+- PUNCT O
+Smads NOUN O
+1/5/8 NUM O
+; PUNCT O
+RFP PROPN B-AC
+, PUNCT O
+red ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+AMPA PROPN B-AC
+, PUNCT O
+α NOUN B-LF
+- PUNCT I-LF
+amino-3 NOUN I-LF
+- PUNCT I-LF
+hydroxy-5 NOUN I-LF
+- PUNCT I-LF
+methyl-4 NOUN I-LF
+- PUNCT I-LF
+isoxazolepropionic NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+BF PROPN O
+, PUNCT O
+bright ADJ O
+field NOUN O
+; PUNCT O
+CCK8 PROPN B-AC
+, PUNCT O
+Cell PROPN B-LF
+Counting PROPN I-LF
+Kit-8 PROPN I-LF
+; PUNCT O
+CGC PROPN B-AC
+, PUNCT O
+cerebellar NOUN B-LF
+granule NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+cKO PROPN B-AC
+, PUNCT O
+Mettl3 NOUN B-LF
+conditional ADJ I-LF
+knockout NOUN I-LF
+; PUNCT O
+CREB PROPN B-AC
+, PUNCT O
+cAMP NOUN B-LF
+responsive ADJ I-LF
+element NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT O
+Ctrl PROPN B-AC
+, PUNCT O
+control NOUN B-LF
+; PUNCT O
+DIV PROPN O
+, PUNCT O
+days NOUN O
+in ADP O
+vitro ADJ O
+; PUNCT O
+Grin1001 PROPN O
+, PUNCT O
+C1 PROPN O
+region NOUN O
+excluded VERB O
+variant NOUN O
+of ADP O
+Grin1 PROPN O
+; PUNCT O
+Grin1011 PROPN O
+, PUNCT O
+C1 PROPN O
+region NOUN O
+included VERB O
+variant NOUN O
+of ADP O
+Grin1 PROPN O
+; PUNCT O
+IGV PROPN B-AC
+, PUNCT O
+integrative ADJ B-LF
+genomics NOUN I-LF
+viewer NOUN I-LF
+; PUNCT O
+METTL3 PROPN B-AC
+, PUNCT O
+methyltransferase NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+3 NUM I-LF
+; PUNCT O
+m6A PROPN B-AC
+, PUNCT O
+N6 NOUN B-LF
+- PUNCT I-LF
+methyladenosine NOUN I-LF
+; PUNCT O
+NMDA PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- PUNCT I-LF
+methyl NOUN I-LF
+- PUNCT I-LF
+D NOUN I-LF
+- PUNCT I-LF
+aspartic NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+PKMT PROPN B-AC
+, PUNCT O
+Lysine NOUN B-LF
+methyltransferase NOUN I-LF
+; PUNCT O
+PPAR PROPN B-AC
+, PUNCT O
+peroxisome NOUN B-LF
+proliferator NOUN I-LF
+- PUNCT I-LF
+activated VERB I-LF
+receptor NOUN I-LF
+; PUNCT O
+PSI PROPN B-AC
+, PUNCT O
+percent NOUN B-LF
+spliced VERB I-LF
+in ADP I-LF
+index NOUN I-LF
+; PUNCT O
+RNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+SEM NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+. PUNCT O
+
+Thus ADV O
+, PUNCT O
+we PRON O
+determined VERB O
+glycemic ADJ O
+control NOUN O
+of ADP O
+p8 NOUN O
+in ADP O
+mice NOUN O
+fed VERB O
+with ADP O
+standard ADJ O
+( PUNCT O
+SD PROPN B-AC
+) PUNCT O
+and CCONJ O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+( PUNCT O
+HFD PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+PRCP NOUN B-AC
+activity NOUN O
+was AUX O
+determined VERB O
+by ADP O
+measuring VERB O
+the DET O
+hydrolysis NOUN O
+of ADP O
+N NOUN B-LF
+- NOUN I-LF
+benzyloxycarbonyl NOUN I-LF
+- NOUN I-LF
+Pro PROPN I-LF
+- NOUN I-LF
+Phe PROPN I-LF
+( PUNCT O
+Z NOUN B-AC
+- NOUN B-AC
+Pro PROPN B-AC
+- NOUN B-AC
+Phe PROPN B-AC
+; PUNCT O
+Bachem PROPN O
+, PUNCT O
+Bubendorf PROPN O
+, PUNCT O
+Switzerland PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+identification NOUN O
+of ADP O
+all DET O
+comorbidities NOUN O
+, PUNCT O
+except SCONJ O
+traumatic ADJ O
+brain NOUN O
+injury NOUN O
+, PUNCT O
+relied VERB O
+on ADP O
+algorithms NOUN O
+developed VERB O
+by ADP O
+SNDS PROPN B-AC
+experts NOUN O
+in ADP O
+collaboration NOUN O
+with ADP O
+the DET O
+institution NOUN O
+in ADP O
+charge NOUN O
+of ADP O
+the DET O
+SNDS PROPN B-AC
+, PUNCT O
+the DET O
+Caisse PROPN B-LF
+Nationale PROPN I-LF
+d’Assurance PROPN I-LF
+Maladie PROPN I-LF
+des PROPN I-LF
+Travailleurs PROPN I-LF
+Salariés PROPN I-LF
+( PUNCT O
+CNAMTS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+36 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+trials NOUN O
+included VERB O
+are AUX O
+as SCONJ O
+follows VERB O
+: PUNCT O
+9 X O
+= PUNCT O
+Australasian PROPN B-LF
+Collaborative PROPN I-LF
+Trial PROPN I-LF
+of ADP I-LF
+Magnesium PROPN I-LF
+Sulphate PROPN I-LF
+( PUNCT O
+ACTOMgSO4 PROPN B-AC
+) PUNCT O
+, PUNCT O
+10 X O
+= PUNCT O
+PREterm NOUN B-LF
+brain NOUN I-LF
+protection NOUN I-LF
+by ADP I-LF
+MAGnesium PROPN I-LF
+sulphate NOUN I-LF
+( PUNCT O
+PREMAG PROPN B-AC
+) PUNCT O
+, PUNCT O
+11 X O
+= PUNCT O
+Magnesium PROPN B-LF
+and CCONJ I-LF
+Neurologic PROPN I-LF
+Endpoints PROPN I-LF
+Trial PROPN I-LF
+( PUNCT O
+MAGNET PROPN B-AC
+) PUNCT O
+, PUNCT O
+12 X O
+= PUNCT O
+MAGnesium PROPN B-LF
+sulphate NOUN I-LF
+for ADP I-LF
+Prevention PROPN I-LF
+of ADP I-LF
+Eclampsia PROPN I-LF
+( PUNCT O
+MAGPIE PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+13 X O
+= PUNCT O
+Beneficial PROPN B-LF
+Effects PROPN I-LF
+of ADP I-LF
+Antenatal PROPN I-LF
+Magnesium PROPN I-LF
+Sulfate PROPN I-LF
+( PUNCT O
+BEAM PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+( PUNCT O
+Cr NOUN O
+= PUNCT O
+creatine NOUN O
+; PUNCT O
+PCr NOUN O
+= PUNCT O
+phosphocreatine NOUN O
+; PUNCT O
+GSH NOUN B-AC
+= PUNCT O
+glutathione NOUN B-LF
+; PUNCT O
+GABA NOUN B-AC
+= PUNCT O
+γ NOUN B-LF
+- NOUN I-LF
+amino NOUN I-LF
+butyric NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+NAA PROPN O
+= PUNCT O
+N NOUN O
+- NOUN O
+acetylaspartic NOUN O
+acid NOUN O
+) PUNCT O
+. PUNCT O
+
+CP NOUN B-AC
+: PUNCT O
+Chronic ADJ B-LF
+Pain NOUN I-LF
+phenotype NOUN I-LF
+
+Abbreviations NOUN O
+: PUNCT O
+ANC PROPN B-AC
+, PUNCT O
+antenatal ADJ B-LF
+care NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+LOS PROPN B-AC
+, PUNCT O
+length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+; PUNCT O
+OR NOUN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+ref NOUN O
+, PUNCT O
+reference NOUN O
+; PUNCT O
+SBA PROPN B-AC
+, PUNCT O
+skilled ADJ B-LF
+birth NOUN I-LF
+attendant NOUN I-LF
+. PUNCT O
+
+Within ADP O
+ENSANUT PROPN O
+, PUNCT O
+we PRON O
+used VERB O
+the DET O
+semiquantitative ADJ B-LF
+food NOUN I-LF
+frequency NOUN I-LF
+questionnaire NOUN I-LF
+( PUNCT O
+SFFQ PROPN B-AC
+) PUNCT O
+to PART O
+estimate VERB O
+baseline ADJ O
+intake NOUN O
+of ADP O
+beverages NOUN O
+and CCONJ O
+snacks NOUN O
+. PUNCT O
+
+India PROPN O
+'s PART O
+Total PROPN B-LF
+Sanitation PROPN I-LF
+Campaign PROPN I-LF
+( PUNCT O
+TSC PROPN B-AC
+) PUNCT O
+is AUX O
+one NUM O
+such ADJ O
+program NOUN O
+that PRON O
+seeks VERB O
+to PART O
+end VERB O
+the DET O
+practice NOUN O
+of ADP O
+open ADJ O
+defecation NOUN O
+by ADP O
+changing VERB O
+social ADJ O
+norms NOUN O
+and CCONJ O
+behaviors NOUN O
+, PUNCT O
+and CCONJ O
+providing VERB O
+technical ADJ O
+support NOUN O
+and CCONJ O
+financial ADJ O
+subsidies NOUN O
+. PUNCT O
+
+OS PROPN B-AC
+: PUNCT O
+outer ADJ O
+segment NOUN O
+; PUNCT O
+ONL PROPN B-AC
+: PUNCT O
+outer ADJ B-LF
+nuclear ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+INL PROPN B-AC
+: PUNCT O
+inner ADJ B-LF
+nuclear ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+GCL PROPN B-AC
+: PUNCT O
+ganglion NOUN B-LF
+cell NOUN I-LF
+layer NOUN I-LF
+. PUNCT O
+
+With SCONJ O
+HIV PROPN O
+prevalence NOUN O
+estimated VERB O
+at ADP O
+7.3 NUM O
+% NOUN O
+among ADP O
+the DET O
+general ADJ O
+population NOUN O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+, PUNCT O
+Uganda PROPN O
+is AUX O
+one NUM O
+of ADP O
+14 NUM O
+priority NOUN O
+countries NOUN O
+identified VERB O
+for ADP O
+high ADJ O
+- PUNCT O
+level NOUN O
+SMC PROPN B-AC
+scale NOUN O
+- PUNCT O
+up NOUN O
+by ADP O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+Joint PROPN B-LF
+United PROPN I-LF
+Nations PROPN I-LF
+Programme PROPN I-LF
+on ADP I-LF
+HIV PROPN I-LF
+/ SYM I-LF
+AIDS PROPN I-LF
+( PUNCT O
+UNAIDS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+calculate VERB O
+QALYs NOUN B-AC
+, PUNCT O
+utilities NOUN O
+are AUX O
+necessary ADJ O
+and CCONJ O
+these PRON O
+can AUX O
+be AUX O
+derived VERB O
+from ADP O
+preference NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+measures NOUN I-LF
+( PUNCT O
+PBMs PROPN B-AC
+) PUNCT O
+, PUNCT O
+such ADJ O
+as ADP O
+the DET O
+EuroQol PROPN B-LF
+five NUM I-LF
+- PUNCT I-LF
+dimensional ADJ I-LF
+questionnaire NOUN I-LF
+( PUNCT O
+EQ-5D PROPN B-AC
+) PUNCT O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+WHO PROPN B-AC
+Study PROPN B-LF
+on ADP I-LF
+Global PROPN I-LF
+Ageing PROPN I-LF
+and CCONJ I-LF
+Adult PROPN I-LF
+Health PROPN I-LF
+( PUNCT O
+SAGE PROPN B-AC
+) PUNCT O
+wave NOUN O
+2 NUM O
+for ADP O
+Ghana PROPN O
+was AUX O
+conducted VERB O
+in ADP O
+2014–2015 NUM O
+, PUNCT O
+as ADP O
+part NOUN O
+of ADP O
+the DET O
+multi ADJ O
+- ADJ O
+country ADJ O
+study NOUN O
+on ADP O
+aging NOUN O
+. PUNCT O
+
+FFPE PROPN B-AC
+, PUNCT O
+formalin NOUN B-LF
+- PUNCT I-LF
+fixed VERB I-LF
+paraffin NOUN I-LF
+- PUNCT I-LF
+embedded VERB I-LF
+; PUNCT O
+HPV PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+papillomavirus NOUN I-LF
+. PUNCT O
+
+The DET O
+results NOUN O
+of ADP O
+the DET O
+examination NOUN O
+are AUX O
+sent VERB O
+to ADP O
+US PROPN O
+state NOUN O
+and CCONJ O
+local ADJ O
+health NOUN O
+departments NOUN O
+via ADP O
+CDC PROPN B-AC
+’s PART O
+Electronic PROPN B-LF
+Disease PROPN I-LF
+Notification PROPN I-LF
+system NOUN I-LF
+( PUNCT O
+EDN PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+Depressive ADJ O
+symptoms NOUN O
+were AUX O
+measured VERB O
+by ADP O
+10 NUM B-LF
+- PUNCT I-LF
+item NOUN I-LF
+Center PROPN I-LF
+for ADP I-LF
+Epidemiologic PROPN I-LF
+Studies PROPN I-LF
+( PUNCT O
+CES PROPN B-AC
+- PUNCT B-AC
+D PROPN B-AC
+10 NUM B-AC
+) PUNCT O
+. PUNCT O
+
+Similarly ADV O
+, PUNCT O
+degradation NOUN O
+of ADP O
+REV NOUN O
+- PUNCT O
+ERBα NOUN O
+by ADP O
+Homologous PROPN B-LF
+to ADP I-LF
+the DET I-LF
+E6 PROPN I-LF
+- PUNCT I-LF
+AP PROPN I-LF
+Carboxyl PROPN I-LF
+Terminus PROPN I-LF
+( PUNCT O
+HECT)-(ARF PROPN B-AC
+- PUNCT O
+BP1 PROPN O
+) PUNCT O
+and CCONJ O
+Really ADV B-LF
+Interesting ADJ I-LF
+New PROPN I-LF
+Gene PROPN I-LF
+( PUNCT O
+RING)-class PROPN B-AC
+E3 NOUN O
+ligases NOUN O
+( PUNCT O
+PAM PROPN O
+) PUNCT O
+is AUX O
+induced VERB O
+by ADP O
+phosphorylation NOUN O
+by ADP O
+glycogen NOUN B-LF
+synthase NOUN I-LF
+kinase NOUN I-LF
+3β NOUN I-LF
+( PUNCT O
+GSK3β PROPN B-AC
+) PUNCT O
+[ X O
+5,6 NUM O
+] PUNCT O
+. PUNCT O
+
+Ceramides NOUN O
+in ADP O
+the DET O
+epidermis NOUN O
+are AUX O
+synthesized VERB O
+by ADP O
+several ADJ O
+enzymes NOUN O
+such ADJ O
+as ADP O
+serine NOUN B-LF
+palmitoyltransferase NOUN I-LF
+( PUNCT O
+SPT PROPN B-AC
+) PUNCT O
+, PUNCT O
+ceramide NOUN B-LF
+synthase NOUN I-LF
+( PUNCT O
+CerS PROPN B-AC
+) PUNCT O
+, PUNCT O
+glucosylceramide NOUN B-LF
+synthase NOUN I-LF
+( PUNCT O
+GCS PROPN B-AC
+) PUNCT O
+, PUNCT O
+β NOUN O
+- NOUN O
+glucocerebrosidese NOUN O
+( PUNCT O
+GBA PROPN B-AC
+) PUNCT O
+, PUNCT O
+sphingomyelin NOUN B-LF
+synthase NOUN I-LF
+( PUNCT O
+SMS PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+acid NOUN B-LF
+sphingomyelinase NOUN I-LF
+( PUNCT O
+ASM PROPN B-AC
+) PUNCT O
+. PUNCT O
+SPT PROPN B-AC
+and CCONJ O
+CerS PROPN B-AC
+are AUX O
+involved VERB O
+in ADP O
+the DET O
+de X O
+novo X O
+synthesis NOUN O
+of ADP O
+ceramides NOUN O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+its PRON O
+activity NOUN O
+can AUX O
+also ADV O
+be AUX O
+negatively ADV O
+regulated VERB O
+by ADP O
+type NOUN O
+I NUM O
+HDACs PROPN B-AC
+, PUNCT O
+protein NOUN B-LF
+inhibitor NOUN I-LF
+of ADP I-LF
+activated ADJ I-LF
+STAT3 PROPN I-LF
+( PUNCT O
+PIAS3 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+suppressor NOUN O
+of ADP O
+cytokine NOUN O
+signaling NOUN O
+3 NUM O
+( PUNCT O
+SOCS3 PROPN B-AC
+) PUNCT O
+[ PUNCT O
+38–42 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+statistical ADJ O
+analyses NOUN O
+, PUNCT O
+data NOUN O
+were AUX O
+modelled VERB O
+using VERB O
+a DET O
+linear ADJ B-LF
+model NOUN I-LF
+( PUNCT O
+LM PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+linear ADJ B-LF
+mixed ADJ I-LF
+model NOUN I-LF
+( PUNCT O
+LMM PROPN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+a DET O
+general ADJ B-LF
+linear ADJ I-LF
+mixed ADJ I-LF
+model NOUN I-LF
+( PUNCT O
+GLMM PROPN B-AC
+) PUNCT O
+with ADP O
+diet NOUN O
+as ADP O
+fixed ADJ O
+and CCONJ O
+independent ADJ O
+experiment NOUN O
+as ADP O
+random ADJ O
+effect NOUN O
+followed VERB O
+by ADP O
+a DET O
+Wald PROPN O
+chi NOUN O
+- PUNCT O
+squared ADJ O
+test NOUN O
+. PUNCT O
+
+Instruments NOUN O
+used VERB O
+included VERB O
+the DET O
+Bayley PROPN B-LF
+Scale PROPN I-LF
+of ADP I-LF
+Infant PROPN I-LF
+Development- PROPN I-LF
+second ADJ I-LF
+edition NOUN I-LF
+( PUNCT O
+BSID PROPN B-AC
+- PUNCT B-AC
+II PROPN B-AC
+) PUNCT O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+, PUNCT O
+Mullen PROPN B-LF
+Scales PROPN I-LF
+for ADP I-LF
+Early PROPN I-LF
+Learning PROPN I-LF
+( PUNCT O
+MSEL PROPN B-AC
+) PUNCT O
+[ PUNCT O
+32 NUM O
+] PUNCT O
+, PUNCT O
+or CCONJ O
+a DET O
+cognitive ADJ O
+test NOUN O
+such ADJ O
+as ADP O
+the DET O
+Stanford PROPN B-LF
+- PUNCT I-LF
+Binet PROPN I-LF
+Fourth PROPN I-LF
+Edition PROPN I-LF
+( PUNCT O
+SB-4 PROPN B-AC
+) PUNCT O
+[ PUNCT O
+33 NUM O
+] PUNCT O
+, PUNCT O
+Wechsler PROPN B-LF
+Preschool PROPN I-LF
+and CCONJ I-LF
+Primary PROPN I-LF
+Scale PROPN I-LF
+for ADP I-LF
+Intelligence PROPN I-LF
+– PUNCT I-LF
+Third PROPN I-LF
+Edition PROPN I-LF
+( PUNCT O
+WPPSI PROPN B-AC
+- PUNCT B-AC
+III PROPN B-AC
+) PUNCT O
+[ PUNCT O
+34 NUM O
+] PUNCT O
+, PUNCT O
+Wechsler PROPN B-LF
+Intelligence PROPN I-LF
+Scale PROPN I-LF
+for ADP I-LF
+Children PROPN I-LF
+– PUNCT I-LF
+Revised VERB I-LF
+( PUNCT O
+WISC PROPN B-AC
+- PUNCT B-AC
+R PROPN B-AC
+) PUNCT O
+[ PUNCT O
+35 NUM O
+] PUNCT O
+, PUNCT O
+or CCONJ O
+Kaufman PROPN B-LF
+Brief PROPN I-LF
+Intelligence PROPN I-LF
+Test PROPN I-LF
+( PUNCT O
+K PROPN B-AC
+- PUNCT B-AC
+BIT PROPN B-AC
+) PUNCT O
+[ PUNCT O
+36 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+solubility NOUN B-LF
+product NOUN I-LF
+constant NOUN O
+, PUNCT O
+Ksp PROPN B-AC
+, PUNCT O
+is AUX O
+the DET O
+equilibrium NOUN O
+constant NOUN O
+used VERB O
+to PART O
+describe VERB O
+the DET O
+dissolution NOUN O
+of ADP O
+a DET O
+solid ADJ O
+in ADP O
+a DET O
+solution NOUN O
+. PUNCT O
+
+CES PROPN B-AC
+, PUNCT O
+chromatin NOUN B-LF
+entry NOUN I-LF
+site NOUN I-LF
+; PUNCT O
+MSL PROPN B-AC
+, PUNCT O
+male NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+lethal NOUN I-LF
+. PUNCT O
+
+AD PROPN B-AC
+, PUNCT O
+adult NOUN B-LF
+day NOUN I-LF
+; PUNCT O
+CHC PROPN B-AC
+, PUNCT O
+cuticular ADJ B-LF
+hydrocarbon NOUN I-LF
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+. PUNCT O
+
+Women NOUN O
+were AUX O
+classified VERB O
+into ADP O
+three NUM O
+groups NOUN O
+according VERB O
+to ADP O
+FPG PROPN B-AC
+level NOUN O
+and CCONJ O
+self NOUN O
+- PUNCT O
+reported VERB O
+history NOUN O
+of ADP O
+DM PROPN B-AC
+( PUNCT O
+normal ADJ O
+FPG PROPN B-AC
+group NOUN O
+: PUNCT O
+FPG PROPN B-AC
+< ADP O
+5.6 NUM O
+mmol NOUN O
+/ SYM O
+L NOUN O
+and CCONJ O
+no DET O
+self NOUN O
+- PUNCT O
+reported VERB O
+history NOUN O
+of ADP O
+DM PROPN B-AC
+; PUNCT O
+impaired ADJ B-LF
+fasting ADJ I-LF
+glucose NOUN I-LF
+[ PUNCT O
+IFG PROPN B-AC
+] PUNCT O
+: PUNCT O
+FPG PROPN B-AC
+5.6–6.9 NUM O
+mmol NOUN O
+/ SYM O
+L NOUN O
+and CCONJ O
+no DET O
+self NOUN O
+- PUNCT O
+reported VERB O
+history NOUN O
+of ADP O
+DM PROPN B-AC
+; PUNCT O
+and CCONJ O
+DM PROPN B-AC
+: PUNCT O
+FPG PROPN B-AC
+≥ ADP O
+7.0 NUM O
+mmol NOUN O
+/ SYM O
+L NOUN O
+or CCONJ O
+self NOUN O
+- PUNCT O
+reported VERB O
+history NOUN O
+of ADP O
+DM PROPN B-AC
+) PUNCT O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+Our PRON O
+results NOUN O
+demonstrate VERB O
+that SCONJ O
+the DET O
+long ADJ O
+- PUNCT O
+term NOUN O
+expression NOUN O
+of ADP O
+disease NOUN O
+- PUNCT O
+causing VERB O
+misfolded ADJ O
+proteins NOUN O
+can AUX O
+lead VERB O
+to ADP O
+an DET O
+abnormal ADJ O
+, PUNCT O
+chronic ADJ O
+stress NOUN O
+response NOUN O
+that SCONJ O
+we PRON O
+now ADV O
+refer VERB O
+to ADP O
+as ADP O
+the DET O
+maladaptive ADJ B-LF
+stress NOUN I-LF
+response NOUN I-LF
+( PUNCT O
+MSR PROPN B-AC
+) PUNCT O
+. PUNCT O
+This DET O
+altered ADJ O
+Q NOUN O
+- PUNCT O
+state NOUN O
+[ PUNCT O
+3]–[6 X O
+] PUNCT O
+, PUNCT O
+which PRON O
+emphasizes VERB O
+that SCONJ O
+the DET O
+structure NOUN O
+of ADP O
+a DET O
+protein NOUN O
+is AUX O
+tightly ADV O
+integrated VERB O
+with ADP O
+a DET O
+dynamic ADJ O
+proteostatic ADJ O
+system NOUN O
+[ PUNCT O
+1],[5],[6],[9 NUM O
+] PUNCT O
+, PUNCT O
+negatively ADV O
+impacts VERB O
+the DET O
+folding NOUN O
+of ADP O
+disease NOUN O
+- PUNCT O
+associated VERB O
+proteins NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+F508del PROPN O
+- PUNCT O
+CFTR PROPN B-AC
+[ PUNCT O
+42 NUM O
+] PUNCT O
+, PUNCT O
+leading VERB O
+to ADP O
+a DET O
+self NOUN O
+- PUNCT O
+propagating VERB O
+proteotoxic ADJ O
+crisis NOUN O
+( PUNCT O
+Figure PROPN O
+8) NUM O
+. PUNCT O
+
+OPSCC PROPN B-AC
+, PUNCT O
+oropharyngeal ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+; PUNCT O
+HPV PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+papillomavirus NOUN I-LF
+; PUNCT O
+FFPE PROPN B-AC
+, PUNCT O
+formalin NOUN B-LF
+- PUNCT I-LF
+fixed VERB I-LF
+, PUNCT I-LF
+paraffin NOUN I-LF
+- PUNCT I-LF
+embedded VERB I-LF
+; PUNCT O
+IHC PROPN B-AC
+, PUNCT O
+immunohistochemical ADJ B-LF
+staining NOUN I-LF
+; PUNCT O
+PCR NOUN B-AC
+- PUNCT B-AC
+MA PROPN B-AC
+, PUNCT O
+multiplex ADJ B-LF
+PCR NOUN I-LF
+- PUNCT I-LF
+MassArray PROPN I-LF
+. PUNCT O
+
+AM INTJ B-AC
+, PUNCT O
+acute ADJ B-LF
+malnutrition NOUN I-LF
+. PUNCT O
+
+Paper NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+Data PROPN I-LF
+Capture PROPN I-LF
+( PUNCT O
+PDC PROPN B-AC
+) PUNCT O
+has AUX O
+historically ADV O
+been AUX O
+the DET O
+main ADJ O
+method NOUN O
+used VERB O
+to PART O
+record VERB O
+information NOUN O
+. PUNCT O
+
+Naïve ADJ O
+T PROPN O
+cells NOUN O
+require VERB O
+activation NOUN O
+by ADP O
+dendritic ADJ B-LF
+cells NOUN I-LF
+( PUNCT O
+DCs PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+AHR PROPN B-AC
+ligands NOUN O
+modulate VERB O
+the DET O
+function NOUN O
+of ADP O
+DCs PROPN B-AC
+from ADP O
+adult ADJ O
+organisms NOUN O
+. PUNCT O
+
+6MWT PROPN B-AC
+: PUNCT O
+6 NUM B-LF
+- PUNCT I-LF
+minute NOUN I-LF
+walk NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+m NOUN O
+: PUNCT O
+distance NOUN O
+in ADP O
+meters NOUN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+the DET O
+past ADJ O
+decades NOUN O
+, PUNCT O
+quantitative ADJ B-LF
+EEG PROPN I-LF
+( PUNCT O
+qEEG PROPN B-AC
+) PUNCT O
+analysis NOUN O
+methods NOUN O
+have AUX O
+been AUX O
+developed VERB O
+to PART O
+identify VERB O
+epilepsy NOUN O
+- PUNCT O
+related VERB O
+signals NOUN O
+[ X O
+9–14 NUM O
+] PUNCT O
+. PUNCT O
+qEEG PROPN B-AC
+is AUX O
+more ADV O
+objective ADJ O
+than ADP O
+visual ADJ O
+analysis NOUN O
+and CCONJ O
+may AUX O
+reveal VERB O
+subtle ADJ O
+signal NOUN O
+features NOUN O
+and CCONJ O
+dynamics NOUN O
+that PRON O
+are AUX O
+difficult ADJ O
+or CCONJ O
+impossible ADJ O
+to PART O
+detect VERB O
+by ADP O
+visual ADJ O
+inspection NOUN O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+In ADP O
+2006 NUM O
+, PUNCT O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+recognised VERB O
+SCA PROPN B-AC
+as ADP O
+a DET O
+global ADJ O
+public ADJ O
+health NOUN O
+problem NOUN O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+RNA NOUN O
+prepared VERB O
+from ADP O
+epidydimis PROPN O
+was AUX O
+used VERB O
+as ADP O
+positive ADJ O
+control NOUN O
+of ADP O
+Hoxa1 PROPN O
+and CCONJ O
+Hoxb1 PROPN O
+. PUNCT O
+cDNA NOUN O
+products NOUN O
+were AUX O
+resolved VERB O
+on ADP O
+2 NUM O
+% NOUN O
+( PUNCT O
+w NOUN O
+/ SYM O
+v NOUN O
+) PUNCT O
+agarose NOUN O
+gels NOUN O
+. PUNCT O
+cDNA NOUN O
+, PUNCT O
+complementary ADJ O
+DNA NOUN O
+; PUNCT O
+HTF PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+tubal ADJ I-LF
+fluid NOUN I-LF
+; PUNCT O
+PC PROPN O
+, PUNCT O
+positive ADJ O
+control NOUN O
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+, PUNCT O
+reverse ADJ O
+transcription NOUN O
+PCR NOUN O
+; PUNCT O
+TLR7/8 PROPN B-AC
+, PUNCT O
+Toll NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+7 NUM I-LF
+/ SYM I-LF
+Toll NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+8 NUM I-LF
+. PUNCT O
+
+BBS4 PROPN B-AC
+, PUNCT O
+Bardet PROPN B-LF
+– PUNCT I-LF
+Biedl PROPN I-LF
+syndrome PROPN I-LF
+4 NUM I-LF
+; PUNCT O
+NRF2 PROPN B-AC
+, PUNCT O
+nuclear ADJ B-LF
+factor NOUN I-LF
+- PUNCT I-LF
+erythroid NOUN I-LF
+2 NUM I-LF
+- PUNCT I-LF
+like ADJ I-LF
+2 NUM I-LF
+. PUNCT O
+
+FSC PROPN O
+- PUNCT O
+A PROPN O
+, PUNCT O
+forward ADJ O
+scatter NOUN O
+area NOUN O
+; PUNCT O
+FSC PROPN O
+- PUNCT O
+H PROPN O
+, PUNCT O
+forward ADJ O
+scatter NOUN O
+height NOUN O
+; PUNCT O
+Hoxa11 PROPN B-AC
+, PUNCT O
+Homeobox PROPN B-LF
+a11 NOUN I-LF
+; PUNCT O
+NK PROPN B-AC
+, PUNCT O
+natural ADJ B-LF
+killer NOUN I-LF
+; PUNCT O
+Treg PROPN B-AC
+, PUNCT O
+T PROPN B-LF
+regulatory ADJ I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+CBV PROPN B-AC
+, PUNCT O
+cerebral ADJ B-LF
+blood NOUN I-LF
+volume NOUN I-LF
+; PUNCT O
+NIRS PROPN B-AC
+, PUNCT O
+near ADJ B-LF
+- PUNCT I-LF
+infrared ADJ I-LF
+spectroscopy NOUN I-LF
+. PUNCT O
+
+The DET O
+C NOUN B-LF
+- ADJ I-LF
+terminal ADJ I-LF
+fragment NOUN I-LF
+of ADP I-LF
+ubiquitin NOUN I-LF
+( PUNCT O
+Cub PROPN B-AC
+) PUNCT O
+was AUX O
+fused VERB O
+to ADP O
+either CCONJ O
+the DET O
+N- NOUN O
+or CCONJ O
+C NOUN O
+- ADJ O
+terminal ADJ O
+end NOUN O
+of ADP O
+Stt7 PROPN O
+and CCONJ O
+expressed VERB O
+in ADP O
+yeast NOUN O
+together ADV O
+with SCONJ O
+the DET O
+N NOUN B-LF
+- ADJ I-LF
+terminal ADJ I-LF
+end NOUN I-LF
+of ADP I-LF
+ubiquitin NOUN I-LF
+( PUNCT O
+Nub PROPN B-AC
+) PUNCT O
+fused VERB O
+to ADP O
+the DET O
+C NOUN O
+- ADJ O
+terminal ADJ O
+end NOUN O
+of ADP O
+the DET O
+endoplasmic ADJ O
+reticulum NOUN O
+( PUNCT O
+ER PROPN O
+) PUNCT O
+protein NOUN O
+Alg5 PROPN O
+, PUNCT O
+which PRON O
+places VERB O
+Nub PROPN B-AC
+on ADP O
+the DET O
+cytoplasmic ADJ O
+side NOUN O
+of ADP O
+the DET O
+membrane NOUN O
+. PUNCT O
+
+Of ADP O
+all DET O
+ABMR PROPN B-AC
+episodes NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+12 NUM O
+) PUNCT O
+, PUNCT O
+2 NUM O
+were AUX O
+associated VERB O
+with ADP O
+antibodies NOUN O
+to ADP O
+angiotensin NOUN B-LF
+II NUM I-LF
+type NOUN I-LF
+1 NUM I-LF
+receptor NOUN I-LF
+( PUNCT O
+AT1R PROPN B-AC
+) PUNCT O
+and CCONJ O
+one NUM O
+with ADP O
+an DET O
+ABO PROPN O
+- PUNCT O
+incompatible ADJ O
+transplant NOUN O
+. PUNCT O
+
+Reduced VERB O
+long ADJ B-LF
+- PUNCT I-LF
+term NOUN I-LF
+depression NOUN I-LF
+( PUNCT O
+LTD NOUN B-AC
+) PUNCT O
+was AUX O
+recently ADV O
+reported VERB O
+in ADP O
+TSC PROPN B-AC
+mutant ADJ O
+mice NOUN O
+. PUNCT O
+
+There PRON O
+was AUX O
+no DET O
+difference NOUN O
+between ADP O
+the DET O
+genotypes NOUN O
+with ADP O
+regard NOUN O
+to ADP O
+T PROPN O
+cell NOUN O
+survival NOUN O
+( PUNCT O
+Figure PROPN O
+6A NUM O
+) PUNCT O
+. PUNCT O
+Proliferative ADJ O
+ability NOUN O
+was AUX O
+addressed VERB O
+by ADP O
+stimulating VERB O
+purified ADJ O
+B PROPN O
+cells NOUN O
+with ADP O
+anti ADJ O
+- ADJ O
+μ ADJ O
+F(ab′)2 NOUN O
+or CCONJ O
+lipopolysaccharide NOUN B-LF
+( PUNCT O
+LPS PROPN B-AC
+) PUNCT O
+and CCONJ O
+measuring VERB O
+3H NOUN O
+- ADJ O
+thymidine NOUN O
+incorporation NOUN O
+( PUNCT O
+Figure PROPN O
+6C NUM O
+) PUNCT O
+. PUNCT O
+c NOUN O
+- ADJ O
+IAP2H570A NOUN O
+/ SYM O
+H570A PROPN O
+B PROPN O
+cells NOUN O
+had VERB O
+enhanced VERB O
+responses NOUN O
+to ADP O
+both DET O
+stimuli NOUN O
+, PUNCT O
+with ADP O
+approximately ADV O
+a PRON O
+3 ADV O
+- ADJ O
+fold ADJ O
+shift NOUN O
+in ADP O
+the DET O
+dose NOUN O
+response NOUN O
+curve NOUN O
+toward ADP O
+lesser ADJ O
+concentrations NOUN O
+of ADP O
+stimulus NOUN O
+compared VERB O
+to ADP O
+wild ADJ O
+type NOUN O
+cells NOUN O
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+used VERB O
+gene NOUN B-LF
+set NOUN I-LF
+enrichment NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+GSEA PROPN B-AC
+) PUNCT O
+[ X O
+39 NUM O
+] X O
+to PART O
+explore VERB O
+a DET O
+gene NOUN O
+expression NOUN O
+data NOUN O
+set NOUN O
+derived VERB O
+from ADP O
+endoscopic ADJ O
+biopsies NOUN O
+of ADP O
+polypoid ADJ O
+and CCONJ O
+nonpolypoid ADJ O
+colorectal ADJ O
+adenomas NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+APGAR PROPN B-AC
+, PUNCT O
+appearance NOUN B-LF
+, PUNCT I-LF
+pulse NOUN I-LF
+, PUNCT I-LF
+grimace NOUN I-LF
+, PUNCT I-LF
+activity NOUN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+respiration NOUN I-LF
+; PUNCT O
+CBS PROPN B-AC
+, PUNCT O
+Statistics PROPN B-LF
+Netherlands PROPN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+CIN PROPN B-AC
+, PUNCT O
+cervical ADJ B-LF
+intraepithelial ADJ I-LF
+neoplasia NOUN I-LF
+; PUNCT O
+IVF PROPN B-AC
+, PUNCT O
+in ADP B-LF
+vitro X I-LF
+fertilization NOUN I-LF
+; PUNCT O
+NICU PROPN O
+, PUNCT O
+neonatal ADJ O
+intensive PROPN O
+care NOUN O
+unit NOUN O
+; PUNCT O
+pPROM NOUN B-AC
+, PUNCT O
+preterm ADJ B-LF
+premature ADJ I-LF
+rupture NOUN I-LF
+of ADP I-LF
+membranes NOUN I-LF
+. PUNCT O
+
+OPD PROPN B-AC
+: PUNCT O
+o NOUN B-LF
+- NOUN I-LF
+phenylenediamine NOUN I-LF
+dihydrochloride NOUN I-LF
+. PUNCT O
+( PUNCT O
+C NOUN O
+) PUNCT O
+Px43 NOUN O
+IgG1 NOUN O
+and CCONJ O
+IgG4 NOUN O
+demonstrate VERB O
+different ADJ O
+relative ADJ O
+affinities NOUN O
+by ADP O
+ELISA PROPN O
+but CCONJ O
+comparable ADJ O
+affinity NOUN O
+by ADP O
+IIF PROPN B-AC
+binding VERB O
+of ADP O
+human ADJ O
+skin NOUN O
+. PUNCT O
+
+Among ADP O
+325 NUM O
+medical ADJ O
+records NOUN O
+identified VERB O
+and CCONJ O
+examined VERB O
+, PUNCT O
+292 NUM O
+( PUNCT O
+89.8 NUM O
+% NOUN O
+) PUNCT O
+patients NOUN O
+from ADP O
+12 NUM O
+different ADJ O
+non ADJ O
+- PUNCT O
+Arabic ADJ O
+- PUNCT O
+speaking VERB O
+tribes NOUN O
+disclosed VERB O
+in ADP O
+the DET O
+medical ADJ O
+notes NOUN O
+that SCONJ O
+they PRON O
+had AUX O
+been AUX O
+attacked VERB O
+by ADP O
+Government PROPN B-LF
+of ADP I-LF
+Sudan PROPN I-LF
+( PUNCT O
+GoS PROPN B-AC
+) PUNCT O
+and/or CCONJ O
+Janjaweed PROPN O
+forces NOUN O
+. PUNCT O
+
+Data NOUN O
+on ADP O
+the DET O
+lifetime NOUN O
+presence NOUN O
+and CCONJ O
+age NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+onset NOUN O
+of ADP O
+Diagnostic PROPN B-LF
+and CCONJ I-LF
+Statistical PROPN I-LF
+Manual PROPN I-LF
+of ADP I-LF
+Mental PROPN I-LF
+Disorders PROPN I-LF
+, PUNCT I-LF
+4th PROPN I-LF
+Edition PROPN I-LF
+( PUNCT O
+DSM PROPN B-AC
+- PUNCT B-AC
+IV PROPN B-AC
+) PUNCT O
+mental ADJ O
+disorders NOUN O
+and CCONJ O
+nonfatal ADJ O
+suicidal ADJ O
+behaviors NOUN O
+were AUX O
+collected VERB O
+via ADP O
+structured ADJ O
+face NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+face NOUN O
+interviews NOUN O
+with ADP O
+108,664 NUM O
+respondents NOUN O
+from ADP O
+21 NUM O
+countries NOUN O
+participating VERB O
+in ADP O
+the DET O
+WHO PROPN O
+World PROPN O
+Mental PROPN O
+Health PROPN O
+Surveys PROPN O
+. PUNCT O
+
+Incremental ADJ B-LF
+cost NOUN I-LF
+- PUNCT I-LF
+effectiveness NOUN I-LF
+ratios NOUN I-LF
+( PUNCT O
+ICERs NOUN B-AC
+) PUNCT O
+were AUX O
+reported VERB O
+separately ADV O
+for ADP O
+the DET O
+four NUM O
+LOS PROPN B-AC
+models NOUN O
+( PUNCT O
+2 NUM O
+, PUNCT O
+6 NUM O
+, PUNCT O
+24 NUM O
+, PUNCT O
+36 NUM O
+months NOUN O
+) PUNCT O
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+the DET O
+Na+ NOUN O
+channel NOUN O
+blocker NOUN O
+tetrodotoxin NOUN B-LF
+( PUNCT O
+TTX PROPN B-AC
+) PUNCT O
+was AUX O
+added VERB O
+to PART O
+the DET O
+MEA PROPN B-AC
+and CCONJ O
+perfusion NOUN O
+media NOUN O
+to PART O
+suppress VERB O
+spontaneous ADJ O
+network NOUN O
+activity NOUN O
+, PUNCT O
+and CCONJ O
+imaging NOUN O
+was AUX O
+continued VERB O
+for ADP O
+additional ADJ O
+1–2 NUM O
+d. NOUN O
+
+BMI- PROPN B-AC
+Body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+, PUNCT O
+WC- PROPN B-AC
+Waist NOUN B-LF
+circumference NOUN I-LF
+, PUNCT O
+WHR- NOUN B-AC
+Waist NOUN B-LF
+hip NOUN I-LF
+ratio NOUN I-LF
+, PUNCT O
+MET PROPN O
+– PUNCT O
+Metabolic PROPN O
+Equivalent PROPN O
+, PUNCT O
+SD NOUN O
+– PUNCT O
+standard ADJ O
+deviation NOUN O
+
+The DET O
+survey NOUN O
+instrument NOUN O
+was AUX O
+adapted VERB O
+from ADP O
+the DET O
+Zambia PROPN O
+Demographic PROPN B-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Surveys PROPN I-LF
+( PUNCT O
+DHS PROPN B-AC
+) PUNCT O
+[ X O
+22 NUM O
+] X O
+and CCONJ O
+comprised VERB O
+three NUM O
+parts NOUN O
+. PUNCT O
+
+On ADP O
+chromosome NOUN O
+6A NOUN O
+a DET O
+locus NOUN O
+was AUX O
+detected VERB O
+for ADP O
+DSB NOUN B-AC
+and CCONJ O
+HI NOUN B-AC
+in ADP O
+the DET O
+north NOUN O
+and CCONJ O
+the DET O
+south NOUN O
+reducing VERB O
+the DET O
+number NOUN B-LF
+of ADP I-LF
+days NOUN I-LF
+from ADP I-LF
+sowing VERB I-LF
+to ADP I-LF
+booting NOUN I-LF
+and CCONJ O
+increasing VERB O
+HI NOUN B-AC
+. PUNCT O
+Chromosome NOUN O
+6B NUM O
+reported VERB O
+the DET O
+highest ADJ O
+number NOUN O
+of ADP O
+regions NOUN O
+with ADP O
+stable ADJ O
+MTAs NOUN B-AC
+( PUNCT O
+3 NUM O
+) PUNCT O
+. PUNCT O
+
+OPV PROPN B-AC
+, PUNCT O
+oral ADJ B-LF
+poliovirus NOUN I-LF
+vaccine NOUN I-LF
+. PUNCT O
+
+CID NOUN B-AC
+, PUNCT O
+complexity NOUN O
+invariant ADJ O
+distance NOUN O
+; PUNCT O
+DTW PROPN B-AC
+, PUNCT O
+dynamic ADJ B-LF
+time NOUN I-LF
+warping VERB I-LF
+distance NOUN O
+; PUNCT O
+variance NOUN O
+, PUNCT O
+fraction NOUN O
+of ADP O
+variance NOUN O
+explained VERB O
+by ADP O
+the DET O
+clustering NOUN O
+; PUNCT O
+silhouette NOUN O
+, PUNCT O
+average ADJ O
+silhouette NOUN O
+width NOUN O
+for ADP O
+all DET O
+glycemic ADJ O
+signature NOUN O
+; PUNCT O
+CH PROPN B-AC
+index NOUN O
+, PUNCT O
+Calinski PROPN B-LF
+- PUNCT I-LF
+Harabasz PROPN I-LF
+index NOUN O
+. PUNCT O
+
+If SCONJ O
+we PRON O
+assume VERB O
+that SCONJ O
+the DET O
+particles NOUN O
+are AUX O
+rigid ADJ O
+spherical ADJ O
+, PUNCT O
+the DET O
+correlation NOUN O
+between ADP O
+DM PROPN B-AC
+specific ADJ O
+resistance NOUN O
+and CCONJ O
+DM PROPN B-LF
+layer NOUN I-LF
+porosity NOUN I-LF
+can AUX O
+be AUX O
+described VERB O
+by ADP O
+Carman PROPN O
+- PUNCT O
+Kozeny PROPN O
+equation NOUN O
+[ X O
+26 NUM O
+] PUNCT O
+. PUNCT O
+α=180(1−εp)ρpdp2εp3(8 NOUN B-AC
+) PUNCT O
+where SCONJ O
+ε NOUN O
+p NOUN O
+is AUX O
+the DET O
+porosity NOUN O
+of ADP O
+DM PROPN B-AC
+layer NOUN O
+, PUNCT O
+ρ NOUN O
+p NOUN O
+is AUX O
+the DET O
+density NOUN O
+of ADP O
+particle NOUN O
+( PUNCT O
+kg NOUN O
+/ SYM O
+m3 NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+d NOUN O
+p NOUN O
+is AUX O
+the DET O
+particle NOUN O
+diameter NOUN O
+( PUNCT O
+m NOUN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+conducted VERB O
+an DET O
+acceptability NOUN O
+, PUNCT O
+feasibility NOUN O
+, PUNCT O
+and CCONJ O
+prevalence NOUN O
+study NOUN O
+of ADP O
+home NOUN O
+- PUNCT O
+based VERB O
+sampling NOUN O
+for ADP O
+STIs PROPN B-AC
+/ SYM O
+BV PROPN B-AC
+among ADP O
+young ADJ O
+men NOUN O
+and CCONJ O
+women NOUN O
+aged VERB O
+15–24 NUM O
+years NOUN O
+old ADJ O
+in ADP O
+a DET O
+health NOUN B-LF
+and CCONJ I-LF
+demographic ADJ I-LF
+surveillance NOUN I-LF
+site NOUN I-LF
+( PUNCT O
+HDSS PROPN B-AC
+) PUNCT O
+in ADP O
+rural ADJ O
+KwaZulu PROPN O
+- PUNCT O
+Natal PROPN O
+, PUNCT O
+South PROPN O
+Africa PROPN O
+. PUNCT O
+
+Sn PROPN B-AC
+, PUNCT O
+sensitivitiy NOUN O
+; PUNCT O
+Sp PROPN B-AC
+, PUNCT O
+specificity NOUN B-LF
+; PUNCT O
+PPV NOUN B-AC
+, PUNCT O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+; PUNCT O
+NPV NOUN B-AC
+, PUNCT O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+; PUNCT O
+AUC NOUN B-AC
+, PUNCT O
+area NOUN O
+under ADP O
+the DET O
+curve NOUN O
+; PUNCT O
+AFP PROPN B-AC
+, PUNCT O
+alpha NOUN B-LF
+- PUNCT I-LF
+fetoprotein NOUN I-LF
+; PUNCT O
+PIVKA PROPN B-AC
+- PUNCT B-AC
+II PROPN B-AC
+, PUNCT O
+protein NOUN B-LF
+induced VERB I-LF
+by ADP I-LF
+vitamin NOUN I-LF
+K NOUN I-LF
+absence NOUN I-LF
+; PUNCT O
+OPN PROPN B-AC
+, PUNCT O
+osteopontin NOUN B-LF
+; PUNCT O
+DKK-1 PROPN B-AC
+, PUNCT O
+Dickkopf PROPN O
+-1 NUM O
+
+¶LAD X B-AC
+— PUNCT O
+left VERB B-LF
+atrial ADJ I-LF
+diameter NOUN I-LF
+
+To PART O
+address VERB O
+this DET O
+question NOUN O
+, PUNCT O
+we PRON O
+utilize VERB O
+a DET O
+“ PUNCT O
+Big ADJ O
+Data PROPN O
+” PUNCT O
+set NOUN O
+of ADP O
+all DET O
+discharge NOUN B-LF
+summary NOUN I-LF
+reports NOUN I-LF
+( PUNCT O
+DSRs PROPN B-AC
+) PUNCT O
+from ADP O
+43 NUM O
+tertiary ADJ O
+general ADJ O
+hospitals NOUN O
+, PUNCT O
+from ADP O
+January PROPN O
+1 NUM O
+, PUNCT O
+2010 NUM O
+to ADP O
+December PROPN O
+31 NUM O
+, PUNCT O
+2012 NUM O
+. PUNCT O
+
+Moderate ADJ B-LF
+acute ADJ I-LF
+malnutrition NOUN I-LF
+( PUNCT O
+MAM PROPN B-AC
+) PUNCT O
+is AUX O
+defined VERB O
+as ADP O
+a DET O
+WHZ<−2 NUM B-AC
+WHZ NOUN B-AC
+but CCONJ O
+≥−3 NUM O
+WHZ NOUN B-AC
+using VERB O
+the DET O
+WHO PROPN O
+Child PROPN O
+Growth PROPN O
+Standards PROPN O
+. PUNCT O
+
+The DET O
+whole ADJ B-LF
+exome NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT O
+WES PROPN B-AC
+) PUNCT O
+approach NOUN O
+was AUX O
+taken VERB O
+, PUNCT O
+with ADP O
+a DET O
+view NOUN O
+to ADP O
+the DET O
+molecular ADJ O
+background NOUN O
+of ADP O
+the DET O
+proband NOUN O
+’s PART O
+complex ADJ O
+phenotype NOUN O
+( PUNCT O
+of ADP O
+moderate ADJ O
+peripheral ADJ O
+neuropathy NOUN O
+and CCONJ O
+mental ADJ O
+retardation NOUN O
+) PUNCT O
+being AUX O
+understood VERB O
+. PUNCT O
+
+Our PRON O
+data NOUN O
+exemplify VERB O
+that SCONJ O
+( PUNCT O
+i X O
+) PUNCT O
+Ginir PROPN B-AC
+RNA NOUN O
+function NOUN O
+is AUX O
+modulated VERB O
+by ADP O
+its PRON O
+full ADJ O
+- PUNCT O
+length NOUN O
+natural ADJ B-LF
+antisense ADJ I-LF
+transcript NOUN I-LF
+( PUNCT O
+NAT PROPN B-AC
+; PUNCT O
+Giniras PROPN B-AC
+) PUNCT O
+, PUNCT O
+( PUNCT O
+ii X O
+) PUNCT O
+Ginir PROPN B-AC
+RNA NOUN O
+targets VERB O
+centrosomal ADJ B-LF
+protein NOUN I-LF
+112 NUM I-LF
+( PUNCT O
+Cep112 PROPN B-AC
+) PUNCT O
+and CCONJ O
+alters VERB O
+its PRON O
+subcellular ADJ O
+localisation NOUN O
+by ADP O
+binding VERB O
+to ADP O
+it PRON O
+, PUNCT O
+( PUNCT O
+iii X O
+) PUNCT O
+breast NOUN B-LF
+cancer NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+susceptibility NOUN I-LF
+protein NOUN I-LF
+( PUNCT O
+Brca1 NOUN B-AC
+) PUNCT O
+and CCONJ O
+Cep112 PROPN B-AC
+proteins NOUN O
+interact VERB O
+with ADP O
+each DET O
+other ADJ O
+in ADP O
+the DET O
+absence NOUN O
+of ADP O
+Ginir PROPN B-AC
+noncoding ADJ O
+RNA NOUN O
+, PUNCT O
+( PUNCT O
+iv X O
+) PUNCT O
+interaction NOUN O
+of ADP O
+Cep112 PROPN B-AC
+protein NOUN O
+with ADP O
+Brca1 NOUN B-AC
+protein NOUN O
+is AUX O
+impaired VERB O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+high ADJ O
+levels NOUN O
+of ADP O
+Ginir PROPN B-AC
+RNA NOUN O
+, PUNCT O
+and CCONJ O
+( PUNCT O
+v X O
+) PUNCT O
+interference NOUN O
+of ADP O
+Cep112 PROPN B-AC
+– SYM O
+Brca1 NOUN B-AC
+interaction NOUN O
+due ADP O
+to ADP O
+increased VERB O
+presence NOUN O
+of ADP O
+Ginir PROPN B-AC
+RNA NOUN O
+causes VERB O
+replicative ADJ O
+stress NOUN O
+and CCONJ O
+induces VERB O
+mitotic ADJ O
+dysregulation NOUN O
+, PUNCT O
+causing VERB O
+genomic ADJ O
+instability NOUN O
+, PUNCT O
+and CCONJ O
+thereby ADV O
+propels VERB O
+cells NOUN O
+towards ADP O
+malignant ADJ O
+transformation NOUN O
+. PUNCT O
+
+Tumors NOUN O
+were AUX O
+staged VERB O
+based VERB O
+upon SCONJ O
+the DET O
+sixth ADJ O
+or CCONJ O
+seventh ADJ O
+tumor NOUN B-LF
+– PUNCT I-LF
+node NOUN I-LF
+– PUNCT I-LF
+metastasis NOUN I-LF
+( PUNCT O
+TNM PROPN B-AC
+) PUNCT O
+classification NOUN O
+of ADP O
+the DET O
+Union PROPN B-LF
+for ADP I-LF
+International PROPN I-LF
+Cancer PROPN I-LF
+Control PROPN I-LF
+( PUNCT O
+UICC PROPN B-AC
+) PUNCT O
+. PUNCT O
+Operative ADJ O
+time NOUN O
+was AUX O
+calculated VERB O
+from ADP O
+the DET O
+electronic ADJ O
+record NOUN O
+on ADP O
+the DET O
+anesthesia NOUN O
+machine NOUN O
+from ADP O
+the DET O
+start NOUN O
+of ADP O
+creating VERB O
+a DET O
+pneumoperitoneum NOUN O
+to ADP O
+the DET O
+end NOUN O
+when SCONJ O
+the DET O
+abdominal ADJ O
+incision NOUN O
+being AUX O
+sutured VERB O
+. PUNCT O
+
+Cataract NOUN O
+extraction NOUN O
+and CCONJ O
+intraocular ADJ B-LF
+lens NOUN I-LF
+( PUNCT O
+IOL PROPN B-AC
+) PUNCT O
+implantation NOUN O
+could AUX O
+thus ADV O
+increase VERB O
+the DET O
+amount NOUN O
+of ADP O
+blue ADJ O
+light NOUN O
+that PRON O
+reaches VERB O
+retina NOUN O
+. PUNCT O
+
+The DET O
+geometric ADJ O
+mean ADJ O
+parasite NOUN O
+density NOUN O
+at ADP O
+baseline NOUN O
+was AUX O
+26,705 NUM O
+/ NUM O
+μl NOUN O
+( PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ PUNCT O
+CI NOUN B-AC
+] PUNCT O
+: PUNCT O
+20,385 NUM O
+to PART O
+34,985 NUM O
+) PUNCT O
+. PUNCT O
+
+GCN PROPN B-AC
+, PUNCT O
+gene NOUN B-LF
+coexpression NOUN I-LF
+network NOUN I-LF
+; PUNCT O
+MPS PROPN B-AC
+, PUNCT O
+mononuclear ADJ B-LF
+phagocyte NOUN I-LF
+system NOUN I-LF
+; PUNCT O
+RNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+scRNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+RNA NOUN I-LF
+- PUNCT I-LF
+seq NOUN I-LF
+. PUNCT O
+
+On ADP O
+the DET O
+other ADJ O
+hand NOUN O
+, PUNCT O
+enzymatic ADJ O
+conversion NOUN O
+of ADP O
+EPA PROPN B-AC
+and CCONJ O
+DHA PROPN B-AC
+can AUX O
+yield VERB O
+highly ADV O
+potent ADJ O
+lipid NOUN O
+mediators NOUN O
+: PUNCT O
+CYP PROPN B-AC
+catalyzed VERB O
+epoxidation NOUN O
+leads VERB O
+e.g. X O
+to ADP O
+anti ADJ O
+- ADJ O
+arrhythmic ADJ O
+acting VERB O
+17(18)-epoxy NOUN B-LF
+eicosatetraenoic NOUN I-LF
+acid NOUN I-LF
+( PUNCT O
+EpETE PROPN B-AC
+) PUNCT O
+from ADP O
+EPA PROPN B-AC
+and CCONJ O
+19(20)-epoxy NOUN B-LF
+docosapentaenoic NOUN I-LF
+acid NOUN I-LF
+( PUNCT O
+EpDPE PROPN B-AC
+) PUNCT O
+from ADP O
+DHA PROPN B-AC
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+Nevertheless ADV O
+, PUNCT O
+the DET O
+SGBIIA PROPN B-AC
+cohort NOUN O
+exhibited VERB O
+a DET O
+lower ADJ O
+DM NOUN B-AC
+risk NOUN O
+after SCONJ O
+we PRON O
+adjusted ADJ O
+for ADP O
+the DET O
+comorbidities NOUN O
+of ADP O
+hypertension NOUN O
+, PUNCT O
+hyperlipidemia NOUN O
+, PUNCT O
+and CCONJ O
+coronary ADJ O
+artery NOUN O
+disease NOUN O
+( PUNCT O
+adjusted ADJ B-LF
+hazard NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+aHR NOUN B-AC
+): PUNCT O
+0.56 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+): PUNCT O
+0.40–0.78 NUM O
+) PUNCT O
+. PUNCT O
+
+Relatively ADV O
+high ADJ O
+concentrations NOUN O
+of ADP O
+phthalates NOUN O
+were AUX O
+reported VERB O
+for ADP O
+M. PROPN O
+edulis PROPN O
+and CCONJ O
+C. PROPN O
+edule PROPN O
+, PUNCT O
+26.36 NUM O
+and CCONJ O
+52.36 NUM O
+ng NOUN O
+g-1 NOUN O
+, PUNCT O
+with SCONJ O
+concentrations NOUN O
+of ADP O
+polycyclic ADJ B-LF
+aromatic ADJ I-LF
+hydrocarbons NOUN I-LF
+( PUNCT O
+PAHs PROPN B-AC
+) PUNCT O
+, PUNCT O
+polybrominated ADJ B-LF
+diphenyl NOUN I-LF
+ethers NOUN I-LF
+( PUNCT O
+PBDEs PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+polychlorinated ADJ B-LF
+biphenyls NOUN I-LF
+( PUNCT O
+PCBs PROPN B-AC
+) PUNCT O
+substantially ADV O
+lower ADJ O
+for ADP O
+both DET O
+organisms NOUN O
+[ PUNCT O
+54 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+have AUX O
+previously ADV O
+shown VERB O
+that SCONJ O
+activation NOUN O
+of ADP O
+the DET O
+ligand NOUN O
+- PUNCT O
+dependent ADJ O
+transcription NOUN O
+factor NOUN O
+aryl NOUN B-LF
+hydrocarbon NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+AhR PROPN B-AC
+) PUNCT O
+by ADP O
+the DET O
+environmental ADJ O
+pollutant NOUN O
+2,3,7,8 NUM B-LF
+- PUNCT I-LF
+tetrachlorodibenzo NOUN I-LF
+- PUNCT I-LF
+p NOUN I-LF
+- PUNCT I-LF
+dioxin NOUN I-LF
+( PUNCT O
+TCDD PROPN B-AC
+) PUNCT O
+affects VERB O
+both CCONJ O
+oral ADJ O
+tolerance NOUN O
+and CCONJ O
+food NOUN O
+allergy NOUN O
+. PUNCT O
+
+Direction ADJ B-LF
+selective ADJ I-LF
+ganglion NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+DSGCs NOUN B-AC
+) PUNCT O
+in ADP O
+the DET O
+retina NOUN O
+are AUX O
+important ADJ O
+in ADP O
+the DET O
+processing NOUN O
+of ADP O
+motion NOUN O
+information NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+= PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+= PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+COR PROPN B-AC
+= PUNCT O
+crude ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+AOR NOUN B-AC
+= PUNCT O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+TC PROPN B-AC
+= PUNCT O
+total ADJ B-LF
+cholesterol NOUN I-LF
+. PUNCT O
+
+GM PROPN O
+, PUNCT O
+geometric ADJ O
+mean NOUN O
+; PUNCT O
+GSD PROPN O
+, PUNCT O
+geometric ADJ O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+LOD PROPN B-AC
+, PUNCT O
+limit NOUN B-LF
+of ADP I-LF
+detection NOUN I-LF
+. PUNCT O
+
+Interestingly ADV O
+, PUNCT O
+the DET O
+increased VERB O
+glucose NOUN O
+levels NOUN O
+stress VERB O
+the DET O
+pancreatic ADJ O
+islets NOUN O
+and CCONJ O
+insulin NOUN O
+- PUNCT O
+sensitive ADJ O
+tissues NOUN O
+, PUNCT O
+leading VERB O
+to ADP O
+hyperproduction NOUN O
+of ADP O
+IL NOUN O
+- PUNCT O
+β NOUN O
+via ADP O
+nucleotide NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+oligomerization NOUN I-LF
+domain NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptors- NOUN I-LF
+, PUNCT I-LF
+leucine NOUN I-LF
+- PUNCT I-LF
+rich ADJ I-LF
+repeat- NOUN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+pyrin NOUN I-LF
+domain NOUN I-LF
+– PUNCT I-LF
+containing VERB I-LF
+3 NUM I-LF
+( PUNCT O
+NLRP3 NOUN B-AC
+) PUNCT O
+inflammasome NOUN O
+[ PUNCT O
+4,5 NUM O
+] PUNCT O
+. PUNCT O
+
+HO PROPN B-AC
+, PUNCT O
+High PROPN O
+Nutrient NOUN O
+Old PROPN O
+Breeding PROPN O
+treatment NOUN O
+; PUNCT O
+HY PROPN B-AC
+, PUNCT O
+High PROPN O
+Nutrient NOUN O
+Young PROPN O
+Breeding PROPN O
+treatment NOUN O
+; PUNCT O
+KLDC PROPN B-AC
+, PUNCT O
+Kullback PROPN B-LF
+- PUNCT I-LF
+Leibler PROPN I-LF
+discrepancy NOUN I-LF
+calibration NOUN I-LF
+; PUNCT O
+LO PROPN B-AC
+, PUNCT O
+Low PROPN O
+Nutrient NOUN O
+Old PROPN O
+Breeding PROPN O
+treatment NOUN O
+; PUNCT O
+LY PROPN B-AC
+, PUNCT O
+Low PROPN O
+Nutrient NOUN O
+Young PROPN O
+Breeding PROPN O
+treatment NOUN O
+. PUNCT O
+
+The DET O
+current ADJ O
+acute ADJ B-LF
+kidney NOUN I-LF
+injury NOUN I-LF
+( PUNCT O
+AKI PROPN B-AC
+) PUNCT O
+risk NOUN O
+prediction NOUN O
+model NOUN O
+for ADP O
+patients NOUN O
+undergoing VERB O
+percutaneous ADJ B-LF
+coronary ADJ I-LF
+intervention NOUN I-LF
+( PUNCT O
+PCI PROPN B-AC
+) PUNCT O
+from ADP O
+the DET O
+American PROPN B-LF
+College PROPN I-LF
+of ADP I-LF
+Cardiology PROPN I-LF
+( PUNCT O
+ACC PROPN B-AC
+) PUNCT O
+National PROPN B-LF
+Cardiovascular PROPN I-LF
+Data PROPN I-LF
+Registry PROPN I-LF
+( PUNCT O
+NCDR PROPN B-AC
+) PUNCT O
+employed VERB O
+regression NOUN O
+techniques NOUN O
+. PUNCT O
+
+BMP11 PROPN B-AC
+, PUNCT O
+Bone PROPN B-LF
+Morphogenetic PROPN I-LF
+Protein PROPN I-LF
+11 NUM I-LF
+; PUNCT O
+RT NOUN O
+- PUNCT O
+PCR PROPN O
+, PUNCT O
+reverse ADJ O
+transcription NOUN O
+polymerase NOUN O
+chain NOUN O
+reaction NOUN O
+; PUNCT O
+Ubx PROPN B-AC
+, PUNCT O
+Ultrabithorax NOUN B-LF
+. PUNCT O
+
+For ADP O
+the DET O
+first ADJ O
+time NOUN O
+, PUNCT O
+we PRON O
+aimed VERB O
+to PART O
+assess VERB O
+the DET O
+stability NOUN O
+of ADP O
+21 NUM B-LF
+- PUNCT I-LF
+deoxycortisol NOUN I-LF
+( PUNCT O
+21Deox NOUN B-AC
+) PUNCT O
+, PUNCT O
+11 NUM B-LF
+- PUNCT I-LF
+deoxycortisol NOUN I-LF
+( PUNCT O
+11Deox NOUN B-AC
+) PUNCT O
+, PUNCT O
+4 NUM B-LF
+- PUNCT I-LF
+androstenedione NOUN I-LF
+( PUNCT O
+4AD NOUN B-AC
+) PUNCT O
+, PUNCT O
+17 NUM B-LF
+- PUNCT I-LF
+hydroxyprogesterone NOUN I-LF
+( PUNCT O
+17OHP NOUN B-AC
+) PUNCT O
+and CCONJ O
+cortisol NOUN B-LF
+( PUNCT O
+Cort NOUN B-AC
+) PUNCT O
+, PUNCT O
+diagnostic ADJ O
+for ADP O
+CAH PROPN B-AC
+, PUNCT O
+in ADP O
+dried VERB B-LF
+blood NOUN I-LF
+spots NOUN I-LF
+( PUNCT O
+DBSs PROPN B-AC
+) PUNCT O
+during ADP O
+a DET O
+1 NUM O
+year NOUN O
+storage NOUN O
+at ADP O
+different ADJ O
+temperatures NOUN O
+. PUNCT O
+
+Considering VERB O
+the DET O
+expression NOUN O
+of ADP O
+DIP2A PROPN B-AC
+in ADP O
+embryonic ADJ O
+and CCONJ O
+early ADJ O
+postnatal ADJ O
+days NOUN O
+, PUNCT O
+we PRON O
+speculate VERB O
+that SCONJ O
+DIP2A PROPN B-AC
+also ADV O
+affects VERB O
+other ADJ O
+processes NOUN O
+of ADP O
+neuronal ADJ O
+development NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+the DET O
+function NOUN O
+of ADP O
+the DET O
+autism NOUN O
+- NOUN O
+associated VERB O
+gene NOUN O
+phosphatidylinositol NOUN B-LF
+3,4,5 NUM I-LF
+- NOUN I-LF
+trisphosphate NOUN I-LF
+- NOUN I-LF
+dependent ADJ I-LF
+Rac PROPN I-LF
+exchanger NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+P PROPN B-AC
+- NOUN B-AC
+Rex1 PROPN B-AC
+) PUNCT O
+in ADP O
+synaptic ADJ O
+transmission NOUN O
+and CCONJ O
+neuronal ADJ O
+migration NOUN O
+[ X O
+69,70 NUM O
+] PUNCT O
+. PUNCT O
+
+Metabolite NOUN O
+analysis NOUN O
+was AUX O
+conducted VERB O
+on ADP O
+a DET O
+thermal ADJ B-LF
+desorption NOUN I-LF
+- PUNCT O
+gas NOUN B-LF
+chromatography NOUN I-LF
+time NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+flight NOUN O
+mass NOUN O
+spectrometer NOUN O
+( PUNCT O
+GC PROPN B-AC
+- PUNCT O
+TOF PROPN O
+- PUNCT O
+MS PROPN O
+) PUNCT O
+platform NOUN O
+( PUNCT O
+Unity PROPN O
+II PROPN O
+TD PROPN B-AC
+with ADP O
+UltrA PROPN O
+autosampler NOUN O
+, PUNCT O
+Markes PROPN O
+International PROPN O
+, PUNCT O
+and CCONJ O
+Micromass PROPN O
+GCT PROPN O
+Premier PROPN O
+, PUNCT O
+Waters PROPN O
+Corp PROPN O
+, PUNCT O
+Manchester PROPN O
+, PUNCT O
+UK PROPN O
+) PUNCT O
+. PUNCT O
+Prior ADV O
+to ADP O
+desorption NOUN O
+, PUNCT O
+100 NUM O
+μl NOUN O
+of ADP O
+an DET O
+internal ADJ B-LF
+standard NOUN I-LF
+( PUNCT O
+IS PROPN B-AC
+; PUNCT O
+1 NUM O
+ppmV NOUN O
+4 NUM O
+- PUNCT O
+bromofluorobenzene NOUN O
+in ADP O
+N2 PROPN O
+; PUNCT O
+Thames PROPN O
+Restek PROPN O
+, PUNCT O
+Bucks PROPN O
+, PUNCT O
+UK PROPN O
+) PUNCT O
+was AUX O
+loaded VERB O
+onto ADP O
+each DET O
+tube NOUN O
+. PUNCT O
+
+Briefly ADV O
+, PUNCT O
+the DET O
+three NUM O
+dilutions NOUN O
+of ADP O
+Essential PROPN B-LF
+Iodine PROPN I-LF
+Drops PROPN I-LF
+( PUNCT O
+EID PROPN B-AC
+) PUNCT O
+containing VERB O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+virus NOUN O
+solution NOUN O
+( PUNCT O
+1:1 NUM O
+; PUNCT O
+2:1 NUM O
+and CCONJ O
+3:1 NUM O
+) PUNCT O
+were AUX O
+tested VERB O
+in ADP O
+triplicates NOUN O
+for ADP O
+virucidal ADJ O
+activity NOUN O
+as SCONJ O
+described VERB O
+by ADP O
+Pelletier PROPN O
+and CCONJ O
+colleagues NOUN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+we PRON O
+confirmed VERB O
+the DET O
+impact NOUN O
+of ADP O
+HF PROPN B-AC
+diet NOUN O
+on ADP O
+striatal ADJ O
+DA NOUN B-AC
+D2 NOUN B-LF
+receptor NOUN I-LF
+( PUNCT O
+D2R PROPN B-AC
+) PUNCT O
+availability NOUN O
+using VERB O
+[ X O
+18F]fallypride X O
+positron NOUN B-LF
+emission NOUN I-LF
+tomography NOUN I-LF
+( PUNCT O
+PET NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Hospital PROPN B-LF
+Based PROPN I-LF
+Health PROPN I-LF
+Technology PROPN I-LF
+Assessment PROPN I-LF
+( PUNCT O
+HB PROPN B-AC
+- PUNCT B-AC
+HTA PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+new ADJ O
+policy NOUN O
+implemented VERB O
+in ADP O
+Poland PROPN O
+to ADP O
+allow VERB O
+for ADP O
+a DET O
+more ADV O
+practical ADJ O
+and CCONJ O
+contextualized ADJ O
+assessment NOUN O
+related VERB O
+to ADP O
+the DET O
+use NOUN O
+of ADP O
+specific ADJ O
+medical ADJ O
+procedures NOUN O
+, PUNCT O
+devices NOUN O
+, PUNCT O
+or CCONJ O
+equipment NOUN O
+. PUNCT O
+
+We PRON O
+found VERB O
+that SCONJ O
+dietary ADJ O
+intervention NOUN O
+with ADP O
+test NOUN O
+food NOUN O
+altered VERB O
+urine NOUN O
+characteristic ADJ O
+such ADJ O
+that SCONJ O
+the DET O
+RSS NOUN B-AC
+for ADP O
+struvite NOUN O
+crystals NOUN O
+was AUX O
+decreased VERB O
+( PUNCT O
+P NOUN O
+= SYM O
+0.03 NUM O
+) PUNCT O
+and CCONJ O
+there PRON O
+tended VERB O
+to ADP O
+be AUX O
+increased VERB O
+resistance NOUN O
+to ADP O
+oxalate NOUN O
+crystal NOUN O
+formation NOUN O
+as SCONJ O
+determined VERB O
+by ADP O
+the DET O
+calcium NOUN B-LF
+oxalate NOUN I-LF
+titrimetric ADJ I-LF
+test NOUN I-LF
+( PUNCT O
+COT NOUN B-AC
+; PUNCT O
+P NOUN O
+= SYM O
+0.06 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+model NOUN O
+was AUX O
+implemented VERB O
+by ADP O
+a DET O
+set NOUN O
+of ADP O
+ordinary ADJ B-LF
+differential ADJ I-LF
+equations NOUN I-LF
+( PUNCT O
+ODEs NOUN B-AC
+) PUNCT O
+[ X O
+18 NUM O
+] PUNCT O
+, PUNCT O
+an DET O
+approach NOUN O
+successfully ADV O
+used VERB O
+to ADP O
+describe VERB O
+the DET O
+cell NOUN O
+cycle NOUN O
+control NOUN O
+in ADP O
+budding VERB O
+yeast NOUN O
+[ X O
+19,20 NUM O
+] PUNCT O
+and CCONJ O
+the DET O
+cellular ADJ O
+response NOUN O
+of ADP O
+yeast NOUN O
+to ADP O
+hyperosmotic ADJ O
+shock NOUN O
+[ X O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+daytime NOUN O
+physical ADJ O
+activity NOUN O
+, PUNCT O
+FSS PROPN B-AC
+and CCONJ O
+sleep NOUN O
+efficiency NOUN O
+, PUNCT O
+the DET O
+mean NOUN O
+change NOUN O
+and CCONJ O
+the DET O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+between ADP O
+baseline NOUN O
+( PUNCT O
+Day PROPN O
+1 NUM O
+) PUNCT O
+and CCONJ O
+Day PROPN O
+28 NUM O
+, PUNCT O
+Day PROPN O
+84 NUM O
+and CCONJ O
+12 NUM O
+weeks NOUN O
+post NOUN O
+- NOUN O
+treatment NOUN O
+( PUNCT O
+Day PROPN O
+168 NUM O
+) PUNCT O
+was AUX O
+calculated VERB O
+. PUNCT O
+
+Furthermore ADV O
+, PUNCT O
+our PRON O
+cryo NOUN B-LF
+- PUNCT I-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT O
+cryo NOUN B-AC
+- PUNCT B-AC
+EM NOUN B-AC
+) PUNCT O
+structure NOUN O
+of ADP O
+the DET O
+50S·ObgE·GMPPNP PROPN B-AC
+complex NOUN O
+indicates VERB O
+that SCONJ O
+the DET O
+evolutionarily ADV O
+conserved VERB O
+N NOUN B-LF
+- PUNCT I-LF
+terminal NOUN I-LF
+domain NOUN I-LF
+( PUNCT O
+NTD PROPN B-AC
+) PUNCT O
+of ADP O
+ObgE PROPN B-AC
+is AUX O
+a DET O
+tRNA NOUN O
+structural ADJ O
+mimic NOUN O
+, PUNCT O
+with ADP O
+specific ADJ O
+interactions NOUN O
+with ADP O
+peptidyl NOUN O
+- PUNCT O
+transferase NOUN O
+center NOUN O
+, PUNCT O
+displaying VERB O
+a DET O
+marked ADJ O
+resemblance NOUN O
+to ADP O
+Class PROPN O
+I NUM O
+release NOUN O
+factors NOUN O
+. PUNCT O
+
+Cardiovascular ADJ O
+risk NOUN O
+factors NOUN O
+included VERB O
+BMI NOUN O
+z NOUN O
+- PUNCT O
+score NOUN O
+, PUNCT O
+waist NOUN O
+circumference NOUN O
+, PUNCT O
+blood NOUN O
+pressure NOUN O
+( PUNCT O
+z NOUN O
+- PUNCT O
+score NOUN O
+) PUNCT O
+and CCONJ O
+estimated VERB O
+cardiorespiratory ADJ B-LF
+fitness NOUN I-LF
+( PUNCT O
+CRF NOUN B-AC
+) PUNCT O
+as SCONJ O
+measured VERB O
+with ADP O
+the DET O
+20 NUM O
+meter NOUN O
+shuttle NOUN O
+run NOUN O
+test NOUN O
+. PUNCT O
+
+To ADP O
+this DET O
+end NOUN O
+, PUNCT O
+we PRON O
+used VERB O
+human ADJ O
+functional ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+fMRI NOUN B-AC
+) PUNCT O
+combined VERB O
+with ADP O
+psychophysics NOUN O
+. PUNCT O
+
+Sensitivity NOUN O
+of ADP O
+qPCR NOUN B-AC
+was AUX O
+approximately ADV O
+82 NUM O
+% PUNCT O
+and CCONJ O
+Negative ADJ B-LF
+Predictive ADJ I-LF
+Value NOUN I-LF
+( PUNCT O
+NPV PROPN B-AC
+) PUNCT O
+79 NUM O
+% PUNCT O
+. PUNCT O
+
+The DET O
+lipid NOUN O
+content NOUN O
+may AUX O
+vary VERB O
+from ADP O
+1 NUM O
+to ADP O
+40 NUM O
+% NOUN O
+of ADP O
+dry ADJ B-LF
+matter NOUN I-LF
+( PUNCT O
+DM NOUN B-AC
+) PUNCT O
+in ADP O
+certain ADJ O
+strains NOUN O
+, PUNCT O
+and CCONJ O
+under ADP O
+special ADJ O
+culture NOUN O
+conditions NOUN O
+the DET O
+level NOUN O
+can AUX O
+go VERB O
+up ADP O
+to ADP O
+85 NUM O
+% NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+reconstituted VERB O
+the DET O
+interaction NOUN O
+of ADP O
+Atg11 PROPN O
+with ADP O
+Atg9 NOUN B-LF
+- PUNCT I-LF
+proteoliposomes NOUN I-LF
+( PUNCT O
+Atg9 NOUN B-AC
+- PUNCT B-AC
+PLs NOUN O
+) PUNCT O
+from ADP O
+purified VERB O
+components NOUN O
+on ADP O
+model NOUN O
+membranes NOUN O
+in ADP O
+vitro ADJ O
+. PUNCT O
+
+EHR PROPN B-AC
+, PUNCT O
+electronic ADJ B-LF
+health NOUN I-LF
+record NOUN I-LF
+; PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+. PUNCT O
+
+Similar ADJ O
+structures NOUN O
+, PUNCT O
+including VERB O
+peroxisome NOUN O
+- PUNCT O
+localized VERB O
+Rab5B PROPN O
+- PUNCT O
+containing VERB O
+membranes NOUN O
+, PUNCT O
+were AUX O
+visible ADJ O
+when SCONJ O
+N. PROPN O
+benthamiana PROPN O
+plants NOUN O
+were AUX O
+infected VERB O
+with ADP O
+Cucumber PROPN B-LF
+necrosis NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+CNV PROPN B-AC
+, PUNCT O
+a DET O
+very ADV O
+close ADJ O
+relative NOUN O
+of ADP O
+TBSV PROPN B-AC
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+2B NUM O
+) PUNCT O
+. PUNCT O
+As SCONJ O
+expected VERB O
+, PUNCT O
+uninfected ADJ O
+N. PROPN O
+benthamiana PROPN O
+plants NOUN O
+did AUX O
+not PART O
+show VERB O
+co NOUN O
+- PUNCT O
+localization NOUN O
+of ADP O
+the DET O
+peroxisomal ADJ O
+GFP PROPN B-AC
+- PUNCT O
+SKL PROPN O
+and CCONJ O
+the DET O
+early ADJ O
+endosomal ADJ O
+AtRab5b PROPN O
+and CCONJ O
+also ADV O
+lacked VERB O
+aggregated VERB O
+peroxisomes NOUN O
+( PUNCT O
+Fig PROPN O
+2B NUM O
+, PUNCT O
+the DET O
+lowest ADJ O
+panel NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+human ADJ B-LF
+umbilical ADJ I-LF
+vein NOUN I-LF
+endothelial ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+HUVEC PROPN B-AC
+) PUNCT O
+used VERB O
+in ADP O
+the DET O
+adhesion NOUN O
+studies NOUN O
+were AUX O
+harvested VERB O
+from ADP O
+umbilical ADJ O
+cords NOUN O
+by ADP O
+treating VERB O
+them PRON O
+with ADP O
+collagenase NOUN O
+. PUNCT O
+
+The DET O
+other ADJ O
+measured VERB O
+plasma NOUN O
+interleukins NOUN B-LF
+( PUNCT O
+IL-2 NOUN B-AC
+, PUNCT O
+IL-5 NOUN B-AC
+, PUNCT O
+IL-6 NOUN B-AC
+, PUNCT O
+IL-10 NOUN B-AC
+, PUNCT O
+IL-13 NOUN B-AC
+, PUNCT O
+IL-21 NOUN B-AC
+, PUNCT O
+IL-22 NOUN B-AC
+, PUNCT O
+IL-27 NOUN B-AC
+, PUNCT O
+INF NOUN O
+- PUNCT O
+γ NOUN O
+or CCONJ O
+TNF NOUN B-AC
+- PUNCT O
+α NOUN O
+) PUNCT O
+were AUX O
+all PRON O
+similar ADJ O
+in ADP O
+Rgp44 NOUN O
+- PUNCT O
+immunized VERB O
+mice NOUN O
+compared VERB O
+to ADP O
+the DET O
+saline ADJ O
+group NOUN O
+. PUNCT O
+
+SR NOUN B-AC
+- PUNCT B-AC
+μCT NOUN B-AC
+, PUNCT O
+synchrotron NOUN B-LF
+radiation NOUN I-LF
+microcomputed VERB I-LF
+tomography NOUN I-LF
+
+The DET O
+average NOUN O
+of ADP O
+three NUM O
+cardiac ADJ O
+cycles NOUN O
+was AUX O
+used VERB O
+for ADP O
+measurements NOUN O
+of ADP O
+cardiac ADJ O
+dimensions NOUN O
+, PUNCT O
+and CCONJ O
+left VERB B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+( PUNCT O
+LVEF PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Significance NOUN O
+was AUX O
+determined VERB O
+by ADP O
+one NUM O
+- PUNCT O
+way NOUN O
+ANOVA NOUN O
+with ADP O
+Tukey PROPN O
+- PUNCT O
+Kramer PROPN O
+post NOUN O
+- PUNCT O
+test NOUN O
+. PUNCT O
+* PUNCT O
+represents VERB O
+p NOUN O
+≤ ADP O
+0.05 NUM O
+; PUNCT O
+* PUNCT O
+* PUNCT O
+represents VERB O
+p NOUN O
+≤ ADP O
+0.01 NUM O
+. PUNCT O
+( PUNCT O
+F NOUN O
+) PUNCT O
+Projection NOUN O
+of ADP O
+signaling NOUN O
+data NOUN O
+from ADP O
+vehicle- NOUN O
+and CCONJ O
+rapamycin NOUN O
+- PUNCT O
+treated VERB O
+samples NOUN O
+onto ADP O
+a DET O
+partial ADJ B-LF
+least ADJ I-LF
+squares NOUN I-LF
+regression NOUN I-LF
+( PUNCT O
+PLSR PROPN B-AC
+) PUNCT O
+model NOUN O
+built VERB O
+from ADP O
+untreated ADJ O
+samples NOUN O
+. PUNCT O
+
+For ADP O
+the DET O
+molecular ADJ O
+analysis NOUN O
+at ADP O
+the DET O
+Hlx1 NOUN O
+hotspot NOUN O
+, PUNCT O
+mice NOUN O
+heterozygous ADJ O
+for ADP O
+the DET O
+B10 PROPN O
+and CCONJ O
+CAST PROPN O
+alleles NOUN O
+at ADP O
+the DET O
+chromosome NOUN B-LF
+1 NUM O
+Hlx1 NOUN O
+hotspot NOUN O
+and CCONJ O
+carrying VERB O
+the DET O
+appropriate ADJ O
+genotype NOUN O
+on ADP O
+Chr PROPN B-AC
+17 NUM O
+have AUX O
+been AUX O
+generated VERB O
+as SCONJ O
+follows VERB O
+: PUNCT O
+CASTxR209 PROPN O
+F1 PROPN O
+hybrids NOUN O
+were AUX O
+generated VERB O
+and CCONJ O
+crossed VERB O
+with ADP O
+B10 PROPN O
+. PUNCT O
+
+Dox PROPN B-AC
+, PUNCT O
+doxycycline NOUN B-LF
+; PUNCT O
+LATS1 PROPN B-AC
+, PUNCT O
+large ADJ B-LF
+tumor NOUN I-LF
+suppressor NOUN I-LF
+kinase NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+MST1 PROPN B-AC
+, PUNCT O
+mammalian ADJ B-LF
+sterile ADJ I-LF
+20 NUM I-LF
+- PUNCT I-LF
+like ADJ I-LF
+kinase NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+PPM1A PROPN B-AC
+, PUNCT O
+protein NOUN B-LF
+phosphatase NOUN I-LF
+magnesium NOUN I-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+1A NOUN I-LF
+; PUNCT O
+TAZ PROPN B-AC
+, PUNCT O
+transcriptional ADJ B-LF
+coactivator NOUN I-LF
+with ADP I-LF
+PDZ NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+motif NOUN I-LF
+; PUNCT O
+TEAD PROPN B-AC
+, PUNCT O
+transcriptional ADJ B-LF
+enhanced ADJ I-LF
+associate NOUN I-LF
+domain NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+; PUNCT O
+YAP PROPN B-AC
+, PUNCT O
+Yes NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+. PUNCT O
+
+At ADP O
+E19 PROPN O
+, PUNCT O
+birth NOUN O
+weight NOUN O
+, PUNCT O
+lung NOUN O
+weight NOUN O
+and CCONJ O
+lung NOUN B-LF
+weight NOUN I-LF
+/ SYM I-LF
+birth NOUN I-LF
+weight NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+LW NOUN B-AC
+/ SYM B-AC
+BW NOUN B-AC
+ratio NOUN B-AC
+) PUNCT O
+were AUX O
+significantly ADV O
+lower ADJ O
+in ADP O
+the DET O
+pups NOUN O
+born VERB O
+of ADP O
+VDL PROPN B-AC
+mothers NOUN O
+than ADP O
+in ADP O
+the DET O
+controls NOUN O
+. PUNCT O
+
+The DET O
+Intra ADJ O
+- ADJ O
+class NOUN O
+Correlation NOUN O
+Coefficient NOUN O
+( PUNCT O
+ICC PROPN B-AC
+) PUNCT O
+, PUNCT O
+Median ADJ B-LF
+Odds NOUN I-LF
+Ratio NOUN I-LF
+( PUNCT O
+MOR PROPN B-AC
+) PUNCT O
+, PUNCT O
+Proportional ADJ B-LF
+Change NOUN I-LF
+in ADP I-LF
+Variance NOUN I-LF
+( PUNCT O
+PCV PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+deviance NOUN O
+( PUNCT O
+-2LL NOUN O
+) PUNCT O
+were AUX O
+used VERB O
+for ADP O
+model NOUN O
+comparison NOUN O
+and CCONJ O
+for ADP O
+checking VERB O
+model NOUN O
+fitness NOUN O
+. PUNCT O
+
+We PRON O
+show VERB O
+that SCONJ O
+amino ADJ O
+- PUNCT O
+terminal ADJ O
+tripeptides NOUN O
+of ADP O
+several ADJ O
+secreted VERB O
+proteins NOUN O
+bind VERB O
+to ADP O
+transmembrane NOUN O
+cargo NOUN O
+receptor NOUN O
+, PUNCT O
+surfeit NOUN B-LF
+locus NOUN I-LF
+protein NOUN I-LF
+4 NUM I-LF
+( PUNCT O
+Surf4 PROPN B-AC
+) PUNCT O
+, PUNCT O
+for ADP O
+increased VERB O
+ER NOUN B-AC
+- PUNCT O
+trafficking NOUN O
+efficiency NOUN O
+. PUNCT O
+
+We PRON O
+identified VERB O
+and CCONJ O
+excluded VERB O
+women NOUN O
+with ADP O
+prior ADJ O
+CKD PROPN B-AC
+, PUNCT O
+CVD PROPN B-AC
+, PUNCT O
+hypertension NOUN O
+, PUNCT O
+or CCONJ O
+diabetes NOUN O
+through ADP O
+a DET O
+linkage NOUN O
+with ADP O
+the DET O
+NPR PROPN B-AC
+using VERB O
+the DET O
+international ADJ B-LF
+classification NOUN I-LF
+of ADP I-LF
+diseases NOUN I-LF
+( PUNCT O
+ICD PROPN B-AC
+) PUNCT O
+codes NOUN O
+( PUNCT O
+S1 PROPN O
+Table PROPN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+next ADV O
+conducted VERB O
+an DET O
+unbiased ADJ O
+, PUNCT O
+data NOUN O
+- PUNCT O
+driven VERB O
+analysis NOUN O
+to ADP O
+prioritize VERB O
+damaging ADJ O
+variants NOUN O
+most ADV O
+likely ADJ O
+to ADP O
+contribute VERB O
+to ADP O
+the DET O
+risk NOUN O
+of ADP O
+developing VERB O
+an DET O
+ED NOUN B-AC
+. PUNCT O
+First ADV O
+, PUNCT O
+we PRON O
+identified VERB O
+all DET O
+genes NOUN O
+mentioned VERB O
+in ADP O
+three NUM O
+or CCONJ O
+more ADJ O
+papers NOUN O
+in ADP O
+the DET O
+PubMed PROPN O
+database NOUN O
+that PRON O
+mention VERB O
+either CCONJ O
+" PUNCT O
+appetite NOUN O
+" PUNCT O
+or CCONJ O
+" PUNCT O
+eating NOUN B-LF
+disorder NOUN I-LF
+" PUNCT O
+( PUNCT O
+S2 PROPN O
+Table NOUN O
+) PUNCT O
+. PUNCT O
+
+DALY PROPN B-AC
+, PUNCT O
+disability NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+year NOUN I-LF
+; PUNCT O
+GBD PROPN B-AC
+, PUNCT O
+Global PROPN B-LF
+Burden PROPN I-LF
+of ADP I-LF
+Disease PROPN I-LF
+Study PROPN I-LF
+. PUNCT O
+
+Analyses NOUN O
+were AUX O
+carried VERB O
+out ADP O
+for ADP O
+all DET O
+participants NOUN O
+randomised VERB O
+to ADP O
+the DET O
+study NOUN O
+( PUNCT O
+ITT NOUN B-AC
+set NOUN O
+, PUNCT O
+n NOUN O
+= SYM O
+573 NUM O
+) PUNCT O
+and CCONJ O
+for ADP O
+the DET O
+per ADP B-LF
+protocol NOUN I-LF
+set NOUN I-LF
+( PUNCT O
+PPS NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+331 NUM O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+a DET O
+cover NOUN B-LF
+crop NOUN I-LF
+( PUNCT O
+CC PROPN B-AC
+) PUNCT O
+experiment NOUN O
+established VERB O
+in ADP O
+2007 NUM O
+and CCONJ O
+repeated VERB O
+at ADP O
+an DET O
+adjacent ADJ O
+site NOUN O
+in ADP O
+2008 NUM O
+, PUNCT O
+we PRON O
+evaluated VERB O
+the DET O
+medium ADJ O
+- PUNCT O
+term NOUN O
+impact NOUN O
+of ADP O
+CC PROPN B-AC
+( PUNCT O
+no DET B-LF
+cover NOUN I-LF
+crop NOUN I-LF
+control NOUN I-LF
+( PUNCT O
+no DET B-AC
+- PUNCT B-AC
+CC PROPN B-AC
+) PUNCT O
+, PUNCT O
+oat NOUN O
+( PUNCT O
+Avena PROPN O
+sativa PROPN O
+L. PROPN O
+) PUNCT O
+, PUNCT O
+oilseed NOUN B-LF
+radish NOUN I-LF
+( PUNCT O
+OSR PROPN B-AC
+, PUNCT O
+Raphanus PROPN O
+sativus PROPN O
+L. PROPN O
+var NOUN O
+. PUNCT O
+oleoferus PROPN O
+Metzg PROPN O
+. PUNCT O
+
+SD NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+
+DRS PROPN B-AC
+, PUNCT O
+Durham PROPN B-LF
+Risk NOUN I-LF
+Score NOUN I-LF
+. PUNCT O
+
+APC PROPN B-AC
+, PUNCT O
+antigen NOUN B-LF
+- PUNCT I-LF
+presenting VERB I-LF
+cell NOUN I-LF
+; PUNCT O
+CNS PROPN B-AC
+, PUNCT O
+central ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+; PUNCT O
+DO PROPN B-AC
+, PUNCT O
+H2 NOUN O
+- PUNCT O
+O NOUN O
+; PUNCT O
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+MOG PROPN B-AC
+, PUNCT O
+myelin NOUN B-LF
+oligodendrocyte NOUN I-LF
+glycoprotein NOUN I-LF
+. PUNCT O
+
+International PROPN O
+funding NOUN O
+, PUNCT O
+including VERB O
+that PRON O
+from ADP O
+governments NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+from ADP O
+PMI PROPN B-AC
+, PUNCT O
+the DET O
+United PROPN O
+Kingdom PROPN O
+’s PART O
+Department PROPN B-LF
+for ADP I-LF
+International PROPN I-LF
+Development PROPN I-LF
+( PUNCT O
+DFID PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+Global PROPN O
+Fund PROPN O
+, PUNCT O
+and CCONJ O
+others NOUN O
+, PUNCT O
+accounts VERB O
+for ADP O
+a DET O
+large ADJ O
+proportion NOUN O
+( PUNCT O
+approximately ADV O
+68 NUM O
+% NOUN O
+[ NUM O
+5 NUM O
+] PUNCT O
+) PUNCT O
+of ADP O
+the DET O
+funds NOUN O
+available ADJ O
+for ADP O
+malaria NOUN O
+control NOUN O
+worldwide ADV O
+. PUNCT O
+
+During ADP O
+chemotropic ADJ O
+interactions NOUN O
+, PUNCT O
+the DET O
+mitogen NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT O
+MAPK PROPN B-AC
+) PUNCT O
+signal NOUN O
+transduction NOUN O
+protein NOUN O
+complex NOUN O
+( PUNCT O
+NRC-1 PROPN O
+, PUNCT O
+MEK-2 PROPN O
+, PUNCT O
+MAK-2 PROPN O
+, PUNCT O
+and CCONJ O
+the DET O
+scaffold NOUN O
+protein NOUN O
+HAM-5 PROPN O
+) PUNCT O
+assembles VERB O
+/ SYM O
+disassembles VERB O
+at ADP O
+the DET O
+CAT PROPN B-AC
+tip NOUN O
+of ADP O
+communicating VERB O
+germlings NOUN O
+with ADP O
+perfectly ADV O
+out ADP O
+of ADP O
+phase NOUN O
+dynamics NOUN O
+to ADP O
+SOFT PROPN O
+, PUNCT O
+a DET O
+scaffold NOUN O
+protein NOUN O
+for ADP O
+components NOUN O
+of ADP O
+the DET O
+MAPK PROPN B-AC
+cell NOUN O
+wall NOUN O
+integrity NOUN O
+pathway NOUN O
+[ PUNCT O
+44–48 NUM O
+] PUNCT O
+. PUNCT O
+
+Incidence NOUN B-LF
+rate NOUN I-LF
+ratios NOUN I-LF
+( PUNCT O
+IRRs NOUN B-AC
+) PUNCT O
+adjusted VERB O
+for ADP O
+placental ADJ O
+malaria NOUN O
+infection NOUN O
+and CCONJ O
+individual ADJ O
+malaria NOUN O
+exposure NOUN O
+. PUNCT O
+
+I.P. NOUN O
+, PUNCT O
+intraperitoneal ADJ O
+; PUNCT O
+LEC PROPN B-AC
+, PUNCT O
+lateral ADJ B-LF
+entorhinal ADJ I-LF
+cortex NOUN I-LF
+; PUNCT O
+LFP PROPN B-AC
+, PUNCT O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+; PUNCT O
+MUA NOUN B-AC
+, PUNCT O
+multiunit NOUN B-LF
+activity NOUN I-LF
+; PUNCT O
+OB NOUN B-AC
+, PUNCT O
+olfactory ADJ B-LF
+bulb NOUN I-LF
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+respiration NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+rhythm NOUN I-LF
+. PUNCT O
+
+With ADP O
+the DET O
+addition NOUN O
+of ADP O
+utilities NOUN O
+, PUNCT O
+the DET O
+immediate ADJ O
+cystectomy NOUN O
+strategy NOUN O
+yielded VERB O
+an DET O
+average ADJ O
+QALE NOUN B-AC
+of ADP O
+12.32 NUM O
+y NOUN O
+and CCONJ O
+remained VERB O
+preferred ADJ O
+over ADP O
+conservative ADJ O
+therapy NOUN O
+by ADP O
+0.35 NUM O
+QALY PROPN B-AC
+( PUNCT O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+years NOUN I-LF
+) PUNCT O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+cART PROPN B-AC
+, PUNCT O
+combination NOUN B-LF
+antiretroviral ADJ I-LF
+therapy NOUN I-LF
+; PUNCT O
+EE&T PROPN B-AC
+, PUNCT O
+Eastern PROPN B-LF
+Europe PROPN I-LF
+and CCONJ I-LF
+Thailand PROPN I-LF
+; PUNCT O
+W&CE PROPN B-AC
+, PUNCT O
+Western PROPN B-LF
+and CCONJ I-LF
+Central PROPN I-LF
+Europe PROPN I-LF
+. PUNCT O
+
+In ADP O
+a DET O
+recent ADJ O
+local ADJ O
+study NOUN O
+among ADP O
+mental ADJ O
+health NOUN O
+professionals NOUN O
+working VERB O
+at ADP O
+the DET O
+Institute PROPN B-LF
+of ADP I-LF
+Mental PROPN I-LF
+Health PROPN I-LF
+( PUNCT O
+IMH PROPN B-AC
+) PUNCT O
+, PUNCT O
+Yang PROPN O
+et PROPN O
+al NOUN O
+[ X O
+23 NUM O
+] X O
+similarly ADV O
+found VERB O
+staff NOUN O
+were AUX O
+experiencing VERB O
+high ADJ O
+levels NOUN O
+of ADP O
+stress NOUN O
+and CCONJ O
+burnout NOUN O
+. PUNCT O
+
+In ADP O
+a DET O
+previous ADJ O
+study NOUN O
+we PRON O
+described VERB O
+how SCONJ O
+RSV PROPN B-AC
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+certain ADJ O
+metabolites NOUN O
+( PUNCT O
+trans NOUN B-LF
+- NOUN I-LF
+resveratrol-3 NOUN I-LF
+- NOUN I-LF
+O NOUN I-LF
+- NOUN I-LF
+sulfate NOUN I-LF
+-3S- NOUN B-AC
+, PUNCT O
+trans NOUN B-LF
+- NOUN I-LF
+resveratrol-3'-O NOUN I-LF
+- NOUN O
+glucuronide NOUN O
+-3G- NOUN B-AC
+and CCONJ O
+trans NOUN B-LF
+- NOUN I-LF
+resveratrol-4'-O NOUN I-LF
+- NOUN O
+glucuronide NOUN O
+-4G- NOUN B-AC
+) PUNCT O
+were AUX O
+able ADJ O
+to ADP O
+modify VERB O
+the DET O
+expression NOUN O
+of ADP O
+genes NOUN O
+related VERB O
+to ADP O
+the DET O
+adipogenic ADJ O
+process NOUN O
+[ PUNCT O
+25 NUM O
+] PUNCT O
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+we PRON O
+serially ADV O
+passaged VERB O
+HPV18 PROPN O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+( PUNCT O
+WT)- NOUN B-AC
+and CCONJ O
+ΔCTCF NOUN O
+- PUNCT O
+genome NOUN O
+– PUNCT O
+containing VERB O
+human ADJ B-LF
+foreskin NOUN I-LF
+keratinocytes NOUN I-LF
+( PUNCT O
+HFKs PROPN B-AC
+) PUNCT O
+and CCONJ O
+performed VERB O
+Southern ADJ O
+blot NOUN O
+analysis NOUN O
+to PART O
+examine VERB O
+HPV18 PROPN O
+episome NOUN O
+copy NOUN O
+- PUNCT O
+number NOUN O
+variation NOUN O
+over ADP O
+time NOUN O
+. PUNCT O
+
+The DET O
+radical ADJ O
+scavenging NOUN O
+ability NOUN O
+of ADP O
+oils NOUN O
+investigated VERB O
+by ADP O
+2,2 NUM B-LF
+- PUNCT I-LF
+diphenyl-1 NOUN I-LF
+- PUNCT I-LF
+picrylhydrazyl NOUN I-LF
+( PUNCT O
+DPPH PROPN B-AC
+) PUNCT O
+assay NOUN O
+revealed VERB O
+that SCONJ O
+the DET O
+IC50 PROPN O
+value NOUN O
+of ADP O
+GCO PROPN B-AC
+was AUX O
+significantly ADV O
+lower ADJ O
+than ADP O
+of ADP O
+RCO PROPN B-AC
+( PUNCT O
+p<0.05 NUM O
+) PUNCT O
+. PUNCT O
+
+Decreases NOUN O
+in ADP O
+trabecular ADJ O
+, PUNCT O
+but CCONJ O
+not PART O
+cortical ADJ O
+, PUNCT O
+bone NOUN O
+volumes NOUN O
+over ADP O
+total ADJ O
+volumes NOUN O
+( PUNCT O
+BV NOUN B-AC
+/ SYM B-AC
+TV NOUN B-AC
+) PUNCT O
+, PUNCT O
+trabecular ADJ B-LF
+bone NOUN I-LF
+number NOUN I-LF
+( PUNCT O
+Tb NOUN B-AC
+. PUNCT B-AC
+N NOUN B-AC
+) PUNCT O
+, PUNCT O
+trabecular ADJ O
+bone NOUN O
+thickness NOUN O
+, PUNCT O
+and CCONJ O
+increase NOUN O
+in ADP O
+trabecular ADJ B-LF
+bone NOUN I-LF
+space NOUN I-LF
+( PUNCT O
+Tb NOUN B-AC
+. PUNCT B-AC
+Sp PROPN B-AC
+) PUNCT O
+were AUX O
+all PRON O
+detected VERB O
+in ADP O
+LmnaHSA PROPN B-AC
+- PUNCT B-AC
+cko NOUN B-AC
+mice NOUN O
+as SCONJ O
+compared VERB O
+with ADP O
+those PRON O
+of ADP O
+littermate NOUN O
+controls NOUN O
+( PUNCT O
+Fig NOUN O
+2 NUM O
+G NOUN O
+and CCONJ O
+2H NOUN O
+) PUNCT O
+( PUNCT O
+S3D NOUN O
+and CCONJ O
+S3E PROPN O
+Fig NOUN O
+) PUNCT O
+. PUNCT O
+
+There PRON O
+were VERB O
+4 NUM O
+trials NOUN O
+conducted VERB O
+in ADP O
+East PROPN O
+Asia PROPN O
+( PUNCT O
+1 NUM O
+Chinese ADJ O
+and CCONJ O
+3 NUM O
+Japanese PROPN O
+) PUNCT O
+and CCONJ O
+5 NUM O
+trials NOUN O
+outside ADP O
+Asia PROPN O
+: PUNCT O
+Acarbose PROPN B-LF
+Cardiovascular PROPN I-LF
+Evaluation PROPN I-LF
+( PUNCT O
+ACE PROPN B-AC
+) PUNCT O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+, PUNCT O
+Action PROPN B-LF
+to PART I-LF
+Control VERB I-LF
+Cardiovascular PROPN I-LF
+Risk PROPN I-LF
+in ADP I-LF
+Diabetes PROPN I-LF
+( PUNCT O
+ACCORD PROPN B-AC
+) PUNCT O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+, PUNCT O
+Action PROPN B-LF
+in ADP I-LF
+Diabetes PROPN I-LF
+and CCONJ I-LF
+Vascular ADJ I-LF
+disease NOUN I-LF
+: PUNCT I-LF
+preterAx NOUN I-LF
+and CCONJ I-LF
+diamicroN ADJ I-LF
+- PROPN I-LF
+MR NOUN I-LF
+Controlled PROPN I-LF
+Evaluation PROPN I-LF
+( PUNCT O
+ADVANCE PROPN B-AC
+) PUNCT O
+[ PUNCT O
+24 NUM O
+] PUNCT O
+, PUNCT O
+Diabetes PROPN B-LF
+Prevention PROPN I-LF
+Program PROPN I-LF
+( PUNCT O
+DPP PROPN B-AC
+) PUNCT O
+[ PUNCT O
+25 NUM O
+] PUNCT O
+, PUNCT O
+Japan PROPN B-LF
+Diabetes PROPN I-LF
+Complications PROPN I-LF
+Study PROPN I-LF
+( PUNCT O
+JDCS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+26 NUM O
+] PUNCT O
+, PUNCT O
+Japan PROPN B-LF
+Elderly PROPN I-LF
+Diabetes PROPN I-LF
+Intervention PROPN I-LF
+Trial PROPN I-LF
+( PUNCT O
+J PROPN B-AC
+- PROPN B-AC
+EDIT PROPN B-AC
+) PUNCT O
+[ PUNCT O
+27 NUM O
+] PUNCT O
+, PUNCT O
+Japanese PROPN B-LF
+Primary PROPN I-LF
+Prevention PROPN I-LF
+of ADP I-LF
+Atherosclerosis PROPN I-LF
+with ADP I-LF
+Aspirin PROPN I-LF
+for ADP I-LF
+Diabetes PROPN I-LF
+trial NOUN O
+( PUNCT O
+JPAD PROPN B-AC
+) PUNCT O
+[ PUNCT O
+28 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+UK PROPN B-LF
+Prospective PROPN I-LF
+Diabetes PROPN I-LF
+Study PROPN I-LF
+33 NUM I-LF
+and CCONJ I-LF
+80 NUM I-LF
+( PUNCT O
+UKPDS PROPN B-AC
+33 NUM B-AC
+and CCONJ B-AC
+80 NUM B-AC
+) PUNCT O
+[ PUNCT O
+29,30 NUM O
+] PUNCT O
+. PUNCT O
+
+8 NUM O
+- PUNCT O
+OHdG NOUN O
+, PUNCT O
+8 NUM O
+- PUNCT O
+hydroxy-2′-deoxyguanosine NOUN O
+; PUNCT O
+BPA PROPN B-AC
+, PUNCT O
+bisphenol NOUN B-LF
+A NOUN I-LF
+; PUNCT O
+DEHP PROPN B-AC
+, PUNCT O
+di(2 NOUN B-LF
+- PUNCT I-LF
+ethylhexyl NOUN I-LF
+) PUNCT I-LF
+phthalate NOUN I-LF
+; PUNCT O
+DOP PROPN B-AC
+, PUNCT O
+di NOUN B-LF
+- PUNCT I-LF
+n NOUN I-LF
+- PUNCT I-LF
+octyl NOUN I-LF
+phthalate NOUN I-LF
+; PUNCT O
+HMW PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+; PUNCT O
+LMW PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+; PUNCT O
+PA PROPN B-AC
+, PUNCT O
+phthalic NOUN B-LF
+acid NOUN I-LF
+. PUNCT O
+
+Bcat2 NOUN O
+, PUNCT O
+β NOUN O
+- NOUN O
+catenin-2 NOUN O
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+. PUNCT O
+
+We PRON O
+conducted VERB O
+a DET O
+two NUM O
+- PUNCT O
+sample NOUN O
+Mendelian ADJ B-LF
+randomization NOUN I-LF
+( PUNCT O
+MR PROPN B-AC
+) PUNCT O
+analysis NOUN O
+to PART O
+evaluate VERB O
+the DET O
+relationship NOUN O
+between ADP O
+coffee NOUN O
+consumption NOUN O
+and CCONJ O
+breast NOUN O
+cancer NOUN O
+risk NOUN O
+using VERB O
+33 NUM O
+single ADJ B-LF
+- PUNCT I-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT O
+SNPs PROPN B-AC
+) PUNCT O
+associated VERB O
+with ADP O
+coffee NOUN O
+consumption NOUN O
+from ADP O
+a DET O
+genome NOUN B-LF
+- PUNCT I-LF
+wide ADJ I-LF
+association NOUN I-LF
+( PUNCT O
+GWA PROPN B-AC
+) PUNCT O
+study NOUN O
+on ADP O
+212,119 NUM O
+female ADJ O
+UK PROPN O
+Biobank PROPN O
+participants NOUN O
+of ADP O
+White ADJ O
+British ADJ O
+ancestry NOUN O
+. PUNCT O
+
+IPW PROPN B-AC
+= PUNCT O
+Inverse ADJ B-LF
+Probability NOUN I-LF
+Weighting NOUN I-LF
+
+An DET O
+adaptive ADJ O
+multi ADJ O
+- PUNCT O
+arm ADJ O
+, PUNCT O
+2 NUM O
+- PUNCT O
+stage NOUN O
+cluster NOUN O
+randomised VERB O
+trial NOUN O
+was AUX O
+conducted VERB O
+between ADP O
+8 NUM O
+August PROPN O
+2016 NUM O
+and CCONJ O
+30 NUM O
+June PROPN O
+2017 NUM O
+, PUNCT O
+with ADP O
+antenatal ADJ B-LF
+care NOUN I-LF
+clinic NOUN I-LF
+( PUNCT O
+ANC PROPN B-AC
+) PUNCT O
+days NOUN O
+( PUNCT O
+i.e. X O
+, PUNCT O
+clusters NOUN O
+of ADP O
+women NOUN O
+attending VERB O
+on ADP O
+a DET O
+single ADJ O
+day NOUN O
+) PUNCT O
+as ADP O
+the DET O
+unit NOUN O
+of ADP O
+randomisation NOUN O
+. PUNCT O
+
+Peptide NOUN O
+composition NOUN O
+was AUX O
+refined VERB O
+using VERB O
+database NOUN B-LF
+2 NUM O
+( PUNCT O
+db-2 NOUN B-AC
+) PUNCT O
+( PUNCT O
+unpublished ADJ O
+data NOUN O
+) PUNCT O
+. PUNCT O
+
+To PART O
+measure VERB O
+work NOUN O
+intensity NOUN O
+or CCONJ O
+aerobic ADJ O
+strain NOUN O
+, PUNCT O
+the DET O
+recording NOUN O
+of ADP O
+heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+valid ADJ O
+method NOUN O
+. PUNCT O
+
+Upon SCONJ O
+ABA PROPN B-AC
+perception NOUN O
+, PUNCT O
+the DET O
+soluble ADJ O
+ABA PROPN B-AC
+receptors NOUN O
+interact VERB O
+with ADP O
+and CCONJ O
+inhibit VERB O
+clade NOUN O
+- PUNCT O
+A NOUN O
+protein NOUN B-LF
+phosphatase NOUN I-LF
+2Cs NOUN I-LF
+( PUNCT O
+PP2Cs NOUN B-AC
+): PUNCT O
+ABA PROPN B-LF
+- PUNCT I-LF
+insensitive ADJ I-LF
+1 NUM I-LF
+( PUNCT O
+ABI1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+ABA PROPN B-LF
+- PUNCT I-LF
+insensitive ADJ I-LF
+2 NUM I-LF
+( PUNCT O
+ABI2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+hypersensitive ADJ B-LF
+to ADP I-LF
+ABA PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+HAB1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+protein NOUN B-LF
+phosphatase NOUN I-LF
+2CA NUM I-LF
+( PUNCT O
+PP2CA PROPN B-AC
+) PUNCT O
+; PUNCT O
+this DET O
+interaction NOUN O
+relieves VERB O
+inhibition NOUN O
+of ADP O
+the DET O
+serine NOUN O
+- PUNCT O
+threonine NOUN O
+kinase NOUN O
+OPEN PROPN B-LF
+STOMATA PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+OST1 PROPN B-AC
+) PUNCT O
+[ PUNCT O
+24 NUM O
+] PUNCT O
+. PUNCT O
+
+CI NOUN B-AC
+= PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+, PUNCT O
+Q1 NOUN B-AC
+- PUNCT B-AC
+Q3 NOUN B-AC
+= PUNCT O
+Quartile NOUN B-LF
+1 NUM I-LF
+– PUNCT I-LF
+Quartile NOUN I-LF
+3 NUM I-LF
+
+We PRON O
+explore VERB O
+whether SCONJ O
+the DET O
+‘ PUNCT O
+Auditory PROPN B-LF
+Stroop PROPN I-LF
+Task PROPN I-LF
+’ PUNCT O
+( PUNCT O
+AST PROPN B-AC
+) PUNCT O
+can AUX O
+be AUX O
+used VERB O
+to PART O
+increase VERB O
+cognitive ADJ O
+load NOUN O
+( PUNCT O
+and CCONJ O
+thereby ADV O
+elicit VERB O
+FOG NOUN B-AC
+) PUNCT O
+, PUNCT O
+simultaneously ADV O
+with ADP O
+visual ADJ O
+cues NOUN O
+( PUNCT O
+as ADP O
+a DET O
+therapeutic ADJ O
+intervention NOUN O
+for ADP O
+FOG NOUN B-AC
+) PUNCT O
+. PUNCT O
+We PRON O
+additionally ADV O
+examined VERB O
+how SCONJ O
+these DET O
+two NUM O
+contrasting VERB O
+effects NOUN O
+might AUX O
+interact VERB O
+in ADP O
+affecting VERB O
+gait NOUN O
+and CCONJ O
+FOG NOUN B-AC
+parameters NOUN O
+. PUNCT O
+
+factor NOUN B-LF
+Xa PROPN I-LF
+
+This DET O
+G1 PROPN O
+transcriptional ADJ O
+circuit NOUN O
+is AUX O
+analogous ADJ O
+to ADP O
+that PRON O
+defined VERB O
+in ADP O
+mammals NOUN O
+by ADP O
+the DET O
+E2F PROPN O
+family NOUN O
+of ADP O
+transcription NOUN O
+factors NOUN O
+and CCONJ O
+the DET O
+retinoblastoma NOUN B-LF
+( PUNCT O
+Rb PROPN B-AC
+) PUNCT O
+tumor NOUN O
+suppressor NOUN O
+protein NOUN O
+. PUNCT O
+
+H3K4me3 NOUN B-AC
+, PUNCT O
+H3 NOUN B-LF
+trimethylation NOUN I-LF
+of ADP I-LF
+lysine NOUN I-LF
+residue NOUN I-LF
+4 NUM I-LF
+. PUNCT O
+
+Overexpression NOUN O
+of ADP O
+cdk5 PROPN B-AC
+( PUNCT O
+either CCONJ O
+alone ADV O
+or CCONJ O
+with ADP O
+its PRON O
+coactivator NOUN O
+, PUNCT O
+p35 NOUN O
+; PUNCT O
+[ X O
+23 NUM O
+] PUNCT O
+) PUNCT O
+or CCONJ O
+inhibition NOUN O
+with ADP O
+DNcdk5 PROPN O
+had VERB O
+no DET O
+significant ADJ O
+effects NOUN O
+( PUNCT O
+p NOUN O
+> SYM O
+0.2 NUM O
+) PUNCT O
+on ADP O
+the DET O
+proliferation NOUN O
+of ADP O
+adult ADJ O
+rat NOUN O
+NPCs NOUN B-AC
+( PUNCT O
+Figure PROPN O
+1A–1E NUM O
+) PUNCT O
+or CCONJ O
+mouse NOUN O
+NPCs NOUN B-AC
+( PUNCT O
+unpublished ADJ O
+data NOUN O
+) PUNCT O
+, PUNCT O
+as SCONJ O
+measured VERB O
+by ADP O
+the DET O
+number NOUN O
+of ADP O
+bromo NOUN B-LF
+- PUNCT I-LF
+deoxy NOUN I-LF
+- PUNCT I-LF
+uridine NOUN I-LF
+( PUNCT O
+BrdU)-incorporating VERB B-AC
+cells NOUN O
+after ADP O
+a DET O
+1 NUM O
+- PUNCT O
+h NOUN O
+pulse NOUN O
+. PUNCT O
+
+Disturbances NOUN O
+in ADP O
+ER PROPN B-AC
+homeostasis NOUN O
+initiate VERB O
+the DET O
+unfolded ADJ B-LF
+protein NOUN I-LF
+response NOUN I-LF
+( PUNCT O
+UPR NOUN B-AC
+) PUNCT O
+implicated VERB O
+in ADP O
+the DET O
+pathogenesis NOUN O
+of ADP O
+many ADJ O
+human ADJ O
+diseases NOUN O
+. PUNCT O
+
+The DET O
+recommended ADJ O
+dosage NOUN O
+regimen NOUN O
+of ADP O
+laronidase NOUN O
+is AUX O
+0.58 NUM O
+mg NOUN O
+/ SYM O
+kg NOUN O
+body NOUN O
+weight NOUN O
+, PUNCT O
+administered VERB O
+once ADV O
+weekly ADV O
+as ADP O
+an DET O
+intravenous ADJ B-LF
+( PUNCT O
+IV PROPN B-AC
+) PUNCT O
+infusion NOUN O
+. PUNCT O
+
+Conducted VERB O
+by ADP O
+the DET O
+Centers PROPN B-LF
+for ADP I-LF
+Disease PROPN I-LF
+Control PROPN I-LF
+and CCONJ I-LF
+Prevention PROPN I-LF
+’s PART O
+( PUNCT O
+CDC PROPN B-AC
+) PUNCT O
+National PROPN O
+Center PROPN O
+for ADP O
+Health PROPN O
+Statistics PROPN O
+( PUNCT O
+NCHS PROPN O
+) PUNCT O
+, PUNCT O
+the DET O
+National PROPN B-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Nutrition PROPN I-LF
+Examination PROPN I-LF
+Survey PROPN I-LF
+( PUNCT O
+NHANES PROPN B-AC
+) PUNCT O
+collects VERB O
+nationally ADV O
+representative ADJ O
+environmental ADJ O
+biomonitoring NOUN O
+data NOUN O
+from ADP O
+about ADV O
+5,000 NUM O
+annual ADJ O
+participants NOUN O
+in ADP O
+each DET O
+two NUM O
+- PUNCT O
+year NOUN O
+cycle NOUN O
+[ PUNCT O
+2,45–48 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AC PROPN B-AC
+, PUNCT O
+Adherence PROPN B-LF
+Club PROPN I-LF
+; PUNCT O
+DiD PROPN B-AC
+, PUNCT O
+difference NOUN B-LF
+in ADP I-LF
+differences NOUN I-LF
+; PUNCT O
+GEE PROPN B-AC
+, PUNCT O
+generalized ADJ B-LF
+estimating NOUN I-LF
+equation NOUN I-LF
+; PUNCT O
+GP PROPN O
+, PUNCT O
+Gauteng PROPN O
+Province PROPN O
+; PUNCT O
+KZN PROPN O
+, PUNCT O
+KwaZulu PROPN O
+Natal PROPN O
+; PUNCT O
+LP PROPN O
+, PUNCT O
+Limpopo PROPN O
+Province PROPN O
+; PUNCT O
+NW PROPN O
+, PUNCT O
+North PROPN O
+West PROPN O
+; PUNCT O
+RD NOUN O
+, PUNCT O
+risk NOUN O
+difference NOUN O
+; PUNCT O
+VL PROPN O
+, PUNCT O
+viral ADJ O
+load NOUN O
+. PUNCT O
+
+We PRON O
+obtained VERB O
+FTD PROPN B-AC
+GWAS PROPN B-AC
+summary NOUN O
+statistic NOUN O
+data NOUN O
+from ADP O
+phase NOUN O
+I NUM O
+of ADP O
+the DET O
+International PROPN B-LF
+FTD PROPN I-LF
+- PUNCT I-LF
+Genomics PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT O
+IFGC PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+consisted VERB O
+of ADP O
+2,154 NUM O
+clinical ADJ O
+FTD PROPN B-AC
+cases NOUN O
+and CCONJ O
+4,308 NUM O
+controls NOUN O
+with ADP O
+genotyped VERB O
+and CCONJ O
+imputed VERB O
+data NOUN O
+at ADP O
+6,026,384 NUM O
+SNPs NOUN B-AC
+( PUNCT O
+Table NOUN O
+1 NUM O
+; PUNCT O
+for ADP O
+additional ADJ O
+details NOUN O
+, PUNCT O
+see VERB O
+[ PRON O
+5 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+At ADP O
+12 NUM O
+months NOUN O
+of ADP O
+age NOUN O
+, PUNCT O
+soluble ADJ O
+and CCONJ O
+insoluble ADJ O
+Aβ40 PROPN O
+and CCONJ O
+Aβ42 PROPN O
+were AUX O
+increased VERB O
+by ADP O
+62 NUM O
+% NOUN O
+, PUNCT O
+52 NUM O
+% NOUN O
+, PUNCT O
+62 NUM O
+% NOUN O
+, PUNCT O
+and CCONJ O
+36 NUM O
+% NOUN O
+in ADP O
+brains NOUN O
+of ADP O
+APPPS1 PROPN O
+– SYM O
+Adamts13−/− SYM O
+mice NOUN O
+, PUNCT O
+respectively ADV O
+, PUNCT O
+compared VERB O
+with ADP O
+those PRON O
+in ADP O
+APPPS1 PROPN O
+littermates NOUN O
+( PUNCT O
+Fig NOUN O
+4A NUM O
+and CCONJ O
+4B NUM O
+) PUNCT O
+. PUNCT O
+Aβ NOUN B-AC
+immunostaining NOUN O
+and CCONJ O
+thioflavin NOUN B-LF
+S PROPN I-LF
+( PUNCT O
+ThS PROPN B-AC
+) PUNCT O
+staining NOUN O
+confirmed VERB O
+this DET O
+observation NOUN O
+, PUNCT O
+showing VERB O
+that SCONJ O
+the DET O
+cortical ADJ O
+and CCONJ O
+hippocampal ADJ O
+plaque NOUN O
+load NOUN O
+were AUX O
+markedly ADV O
+elevated ADJ O
+in ADP O
+APPPS1 PROPN O
+– SYM O
+Adamts13−/− SYM O
+mice NOUN O
+compared VERB O
+with ADP O
+APPPS1 PROPN O
+mice NOUN O
+( PUNCT O
+Fig NOUN O
+4C NUM O
+, PUNCT O
+4D NUM O
+and CCONJ O
+4E NUM O
+) PUNCT O
+. PUNCT O
+Furthermore ADV O
+, PUNCT O
+APPPS1 PROPN O
+– SYM O
+Adamts13−/− SYM O
+mice NOUN O
+developed VERB O
+2.3 NUM O
+- PUNCT O
+fold ADJ O
+and CCONJ O
+1.7 NUM O
+- PUNCT O
+fold ADJ O
+increases NOUN O
+in ADP O
+cerebral ADJ B-LF
+amyloid NOUN I-LF
+angiopathy NOUN I-LF
+( PUNCT O
+CAA PROPN B-AC
+) PUNCT O
+and CCONJ O
+parenchymal ADJ O
+amyloid NOUN O
+deposition NOUN O
+, PUNCT O
+respectively ADV O
+, PUNCT O
+as SCONJ O
+measured VERB O
+by ADP O
+in ADP O
+vivo ADJ O
+multiphoton NOUN O
+imaging NOUN O
+of ADP O
+methoxy NOUN O
+- PUNCT O
+X04 NOUN O
++ NOUN O
+amyloid NOUN O
+plaques NOUN O
+and CCONJ O
+Tetramethylrhodamine NOUN B-LF
+( PUNCT O
+TMR)-dextran NOUN B-AC
+angiopathy NOUN O
+( PUNCT O
+Fig NOUN O
+4F NUM O
+and CCONJ O
+4 NUM O
+G NOUN O
+) PUNCT O
+. PUNCT O
+Notably ADV O
+, PUNCT O
+the DET O
+CAA PROPN B-AC
+load NOUN O
+was AUX O
+positively ADV O
+correlated VERB O
+with ADP O
+the DET O
+BBB PROPN B-AC
+permeability NOUN O
+determined VERB O
+by ADP O
+the DET O
+permeability NOUN B-LF
+surface NOUN I-LF
+( PUNCT O
+PS PROPN B-AC
+) PUNCT O
+product NOUN O
+for ADP O
+FITC PROPN B-AC
+- PUNCT O
+dextran NOUN O
+in ADP O
+APPPS1 PROPN O
+and CCONJ O
+APPPS1 PROPN O
+– SYM O
+Adamts13−/− SYM O
+mice NOUN O
+( PUNCT O
+Fig NOUN O
+4H NUM O
+) PUNCT O
+. PUNCT O
+
+Plus NOUN O
+– PUNCT O
+minus NOUN O
+values NOUN O
+are AUX O
+means NOUN O
+± ADP O
+standard ADJ B-LF
+error NOUN I-LF
+( PUNCT O
+SE NOUN B-AC
+) PUNCT O
+. PUNCT O
+Analysis NOUN O
+of ADP O
+covariance NOUN O
+was AUX O
+used VERB O
+to PART O
+assess VERB O
+differences NOUN O
+between ADP O
+groups NOUN O
+at ADP O
+follow NOUN O
+- PUNCT O
+up NOUN O
+, PUNCT O
+adjusted VERB O
+for ADP O
+baseline NOUN O
+. PUNCT O
+
+The DET O
+individual ADJ O
+values NOUN O
+represent VERB O
+the DET O
+percentage NOUN O
+of ADP O
+total ADJ O
+number NOUN O
+of ADP O
+dogs NOUN O
+in ADP O
+each DET O
+breed NOUN O
+with ADP O
+Merle PROPN O
+mosaicism NOUN O
+detected VERB O
+[ X O
+ASD PROPN B-AC
+– PUNCT O
+Australian PROPN B-LF
+Shepherd PROPN I-LF
+Dog PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+40 NUM O
+) PUNCT O
+, PUNCT O
+AK PROPN B-AC
+– PUNCT O
+Australian PROPN B-LF
+Koolie PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+23 NUM O
+) PUNCT O
+, PUNCT O
+BC PROPN B-AC
+– PUNCT O
+Border PROPN B-LF
+Collie PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+18 NUM O
+) PUNCT O
+, PUNCT O
+D PROPN O
+– PUNCT O
+Dachshund PROPN O
+( PUNCT O
+n NOUN O
+= SYM O
+9 NUM O
+) PUNCT O
+, PUNCT O
+LC PROPN B-AC
+– PUNCT O
+Louisiana PROPN B-LF
+Catahoula PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+73 NUM O
+) PUNCT O
+, PUNCT O
+MAUS PROPN B-AC
+– PUNCT O
+Miniature PROPN B-LF
+Australian PROPN I-LF
+Shepherd PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+2 NUM O
+) PUNCT O
+, PUNCT O
+SSD PROPN B-AC
+– PUNCT O
+Shetland PROPN B-LF
+Sheepdog PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+2 NUM O
+) PUNCT O
+, PUNCT O
+FB PROPN B-AC
+– PUNCT O
+French PROPN B-LF
+Bulldog PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+2 NUM O
+) PUNCT O
+, PUNCT O
+WS PROPN B-AC
+– PUNCT O
+Welsh PROPN B-LF
+Sheepdog PROPN I-LF
+( PUNCT O
+n NOUN O
+= SYM O
+3 NUM O
+) PUNCT O
+, PUNCT O
+M PROPN O
+– PUNCT O
+Mudi PROPN O
+( PUNCT O
+n NOUN O
+= SYM O
+2 NUM O
+) PUNCT O
+] PUNCT O
+of ADP O
+all DET O
+tested VERB O
+dogs NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+181 NUM O
+) PUNCT O
+. PUNCT O
+
+Animals NOUN O
+were AUX O
+anaesthetized VERB O
+by ADP O
+2%-Isoflurane NOUN O
+inhalation NOUN O
+, PUNCT O
+intubated VERB O
+and CCONJ O
+ventilated VERB O
+with ADP O
+100 NUM O
+% NOUN O
+oxygen NOUN O
+( PUNCT O
+0.7 NUM O
+ml/100 NUM O
+g NOUN O
+bodyweight NOUN B-LF
+[ PUNCT O
+BW NOUN B-AC
+] PUNCT O
+, PUNCT O
+90 NUM O
+/ SYM O
+min NOUN O
+) PUNCT O
+and CCONJ O
+cardiac ADJ O
+hypertrophy NOUN O
+was AUX O
+induced VERB O
+as SCONJ O
+described VERB O
+from ADP O
+Zaha PROPN O
+and CCONJ O
+colleagues NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+Cao PROPN O
+and CCONJ O
+Sudhof PROPN O
+[ X O
+56 NUM O
+] X O
+have AUX O
+recently ADV O
+discovered VERB O
+that PRON O
+the DET O
+APP PROPN B-AC
+C PROPN O
+- NOUN O
+terminal ADJ O
+fragment NOUN O
+generated VERB O
+by ADP O
+α- NOUN O
+or CCONJ O
+β NOUN O
+- NOUN O
+secretase NOUN O
+is AUX O
+itself PRON O
+cleaved VERB O
+to PART O
+release VERB O
+Aβ PROPN B-AC
+and CCONJ O
+an DET O
+APP PROPN B-LF
+intracellular ADJ I-LF
+domain NOUN I-LF
+( PUNCT O
+AICD PROPN B-AC
+) PUNCT O
+that PRON O
+diffuses VERB O
+into ADP O
+the DET O
+nucleus NOUN O
+, PUNCT O
+possibly ADV O
+acting VERB O
+there ADV O
+as ADP O
+a DET O
+transcription NOUN O
+factor NOUN O
+. PUNCT O
+
+ALD PROPN B-AC
+, PUNCT O
+alcoholic ADJ B-LF
+liver NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+HCV PROPN B-AC
+, PUNCT O
+hepatitis NOUN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+; PUNCT O
+NAFLD PROPN B-AC
+, PUNCT O
+non ADJ O
+- ADJ O
+alcoholic ADJ O
+fatty ADJ O
+liver NOUN O
+disease NOUN O
+. PUNCT O
+
+LDSm NOUN B-AC
+= PUNCT O
+Latent PROPN B-LF
+Difference PROPN I-LF
+Score PROPN I-LF
+model NOUN I-LF
+, PUNCT O
+Latent PROPN O
+GSE PROPN B-AC
+= PUNCT O
+General PROPN B-LF
+Self PROPN I-LF
+- PUNCT I-LF
+Efficacy PROPN I-LF
+, PUNCT O
+TCS PROPN B-AC
+= PUNCT O
+Transition PROPN B-LF
+Competence PROPN I-LF
+Scale PROPN I-LF
+, PUNCT O
+PAM PROPN B-AC
+= PUNCT O
+Patient PROPN O
+Activation PROPN O
+Measurement PROPN O
+– PUNCT O
+German PROPN O
+Youth PROPN O
+Version PROPN O
+. PUNCT O
+
+Medium ADJ B-LF
+- PUNCT I-LF
+chain NOUN I-LF
+acyl NOUN I-LF
+- PUNCT I-LF
+CoA NOUN I-LF
+dehydrogenase NOUN I-LF
+( PUNCT O
+MCAD PROPN B-AC
+) PUNCT O
+deficiency NOUN O
+is AUX O
+one NUM O
+of ADP O
+the DET O
+most ADV O
+common ADJ O
+inherited VERB O
+disorders NOUN O
+of ADP O
+metabolism NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+DAS28 PROPN B-AC
+, PUNCT O
+Disease PROPN B-LF
+Activity PROPN I-LF
+Score-28 PROPN I-LF
+; PUNCT O
+TNFi PROPN B-AC
+, PUNCT O
+tumour NOUN O
+necrosis NOUN O
+factor NOUN O
+inhibitor NOUN O
+
+Within ADP O
+a DET O
+Developmental PROPN B-LF
+Origins PROPN I-LF
+of ADP I-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Disease PROPN I-LF
+( PUNCT O
+DOHaD PROPN B-AC
+) PUNCT O
+framework NOUN O
+, PUNCT O
+the DET O
+first ADJ O
+1,000 NUM O
+days NOUN O
+of ADP O
+life NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+the DET O
+period NOUN O
+from ADP O
+conception NOUN O
+to ADP O
+age NOUN O
+2 NUM O
+years NOUN O
+, PUNCT O
+is AUX O
+regarded VERB O
+as ADP O
+a DET O
+critical ADJ O
+period NOUN O
+for ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+cardiovascular ADJ O
+health NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+As ADP O
+a DET O
+first ADJ O
+step NOUN O
+toward ADP O
+this DET O
+goal NOUN O
+, PUNCT O
+we PRON O
+asked VERB O
+whether SCONJ O
+conditions NOUN O
+could AUX O
+be AUX O
+found VERB O
+that PRON O
+allow VERB O
+cultured VERB O
+cells NOUN O
+to ADP O
+proliferate VERB O
+despite SCONJ O
+an DET O
+activated VERB O
+UPR NOUN B-AC
+. PUNCT O
+We PRON O
+chose VERB O
+as ADP O
+our PRON O
+experimental ADJ O
+cell NOUN O
+type NOUN O
+mouse NOUN B-LF
+embryonic ADJ I-LF
+fibroblasts NOUN I-LF
+( PUNCT O
+MEFs PROPN B-AC
+) PUNCT O
+, PUNCT O
+because SCONJ O
+, PUNCT O
+as ADP O
+primary ADJ O
+non ADJ O
+- ADJ O
+immortalized ADJ O
+cells NOUN O
+, PUNCT O
+they PRON O
+are AUX O
+less ADV O
+likely ADJ O
+than ADP O
+immortalized ADJ O
+cell NOUN O
+lines NOUN O
+to ADP O
+be AUX O
+intrinsically ADV O
+resistant ADJ O
+to ADP O
+stress NOUN O
+. PUNCT O
+
+CDS PROPN B-AC
+, PUNCT O
+coding VERB B-LF
+DNA NOUN I-LF
+sequence NOUN I-LF
+; PUNCT O
+RPF PROPN B-AC
+, PUNCT O
+ribosome NOUN B-LF
+- PUNCT I-LF
+protected VERB I-LF
+mRNA NOUN I-LF
+fragment NOUN I-LF
+; PUNCT O
+SE PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+; PUNCT O
+TE NOUN B-AC
+, PUNCT O
+translational ADJ B-LF
+efficiency NOUN I-LF
+; PUNCT O
+uORF NOUN B-AC
+, PUNCT O
+upstream ADJ B-LF
+open ADJ I-LF
+reading NOUN I-LF
+frame NOUN I-LF
+. PUNCT O
+
+We PRON O
+did AUX O
+not PART O
+find VERB O
+support NOUN O
+for ADP O
+this DET O
+hypothesis NOUN O
+in ADP O
+our PRON O
+data NOUN O
+, PUNCT O
+as ADP O
+there PRON O
+was VERB O
+no DET O
+association NOUN O
+between ADP O
+antagonism NOUN O
+and CCONJ O
+higher ADJ O
+levels NOUN O
+of ADP O
+pleiotropy NOUN O
+, PUNCT O
+measured VERB O
+either CCONJ O
+as ADP O
+tissue NOUN O
+breadth NOUN O
+τ NOUN O
+[ X O
+43 NUM O
+] X O
+( PUNCT O
+W NOUN O
+= SYM O
+1,264,700 NUM O
+, PUNCT O
+P NOUN O
+= SYM O
+0.70 NUM O
+) PUNCT O
+or CCONJ O
+as ADP O
+the DET O
+number NOUN O
+of ADP O
+protein NOUN B-LF
+– PUNCT I-LF
+protein NOUN I-LF
+interactions NOUN I-LF
+( PUNCT O
+PPIs PROPN B-AC
+) PUNCT O
+[ X O
+44 NUM O
+] X O
+( PUNCT O
+F1,5276 NUM O
+= SYM O
+2.43 NUM O
+, PUNCT O
+P NOUN O
+= SYM O
+0.12 NUM O
+) PUNCT O
+. PUNCT O
+
+IUGR PROPN B-AC
+, PUNCT O
+intrauterine ADJ B-LF
+growth NOUN I-LF
+restricted VERB I-LF
+; PUNCT O
+UNI PROPN B-AC
+- PUNCT B-AC
+X PROPN B-AC
+, PUNCT O
+uninephrectomized VERB B-LF
+. PUNCT O
+
+ACC PROPN B-AC
+, PUNCT O
+acetyl NOUN B-LF
+- PUNCT I-LF
+coA NOUN I-LF
+carboxylase NOUN I-LF
+; PUNCT O
+ChREBP PROPN B-AC
+, PUNCT O
+carbohydrate NOUN B-LF
+- PUNCT I-LF
+responsive ADJ I-LF
+element NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT O
+CON PROPN O
+, PUNCT O
+control NOUN O
+; PUNCT O
+E2 PROPN B-AC
+, PUNCT O
+estradiol NOUN B-LF
+; PUNCT O
+EHHADH PROPN B-AC
+, PUNCT O
+enoyl NOUN O
+- PUNCT O
+coA NOUN O
+hydratase NOUN O
+and CCONJ O
+3 NUM O
+- PUNCT O
+hydroxyacyl NOUN O
+coA NOUN O
+; PUNCT O
+Fas PROPN B-AC
+, PUNCT O
+fatty ADJ B-LF
+acid NOUN I-LF
+synthase NOUN I-LF
+; PUNCT O
+GAPDH PROPN B-AC
+, PUNCT O
+glyceraldehyde-3 NOUN B-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+; PUNCT O
+HFD PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+; PUNCT O
+IPITT PROPN B-AC
+, PUNCT O
+intraperitoneal ADJ B-LF
+insulin NOUN I-LF
+tolerance NOUN I-LF
+test NOUN I-LF
+; PUNCT O
+ME1 PROPN B-AC
+, PUNCT O
+cytosolic ADJ B-LF
+malic ADJ I-LF
+enzyme NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+OVX PROPN B-AC
+, PUNCT O
+ovariectomy NOUN B-LF
+; PUNCT O
+p NOUN B-AC
+- PUNCT B-AC
+ACC PROPN B-AC
+, PUNCT O
+phosphorylated VERB B-LF
+acetyl NOUN I-LF
+- PUNCT I-LF
+coA NOUN I-LF
+carboxylase NOUN I-LF
+; PUNCT O
+SCD-1 PROPN B-AC
+, PUNCT O
+stearoyl NOUN B-LF
+- PUNCT I-LF
+coA NOUN I-LF
+desaturase-1 NOUN I-LF
+; PUNCT O
+SREBP-1c PROPN B-AC
+, PUNCT O
+sterol NOUN B-LF
+regulatory ADJ I-LF
+element NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+- PUNCT I-LF
+c NOUN I-LF
+; PUNCT O
+TG PROPN B-AC
+, PUNCT O
+triglyceride NOUN B-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+This DET O
+study NOUN O
+used VERB O
+the DET O
+monthly ADJ O
+income NOUN O
+calculated VERB O
+from ADP O
+the DET O
+NHI PROPN O
+premium NOUN O
+as ADP O
+a DET O
+proxy NOUN O
+for ADP O
+individual ADJ O
+socioeconomic ADJ B-LF
+status NOUN I-LF
+( PUNCT O
+SES PROPN B-AC
+) PUNCT O
+. PUNCT O
+Individuals NOUN O
+were AUX O
+classified VERB O
+into ADP O
+three NUM O
+income NOUN O
+groups NOUN O
+: PUNCT O
+( PUNCT O
+1 X O
+) PUNCT O
+low ADJ O
+( PUNCT O
+< PUNCT O
+NT$15,840 NUM O
+per ADP O
+month NOUN O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+2 X O
+) PUNCT O
+medium ADJ O
+( PUNCT O
+NT$15,840 NUM O
+– SYM O
+NT$25,000 NUM O
+per ADP O
+month NOUN O
+) PUNCT O
+; PUNCT O
+and CCONJ O
+( PUNCT O
+3 X O
+) PUNCT O
+high ADJ O
+( PUNCT O
+> PUNCT O
+NT$25,000 NUM O
+per ADP O
+month NOUN O
+) PUNCT O
+. PUNCT O
+
+Initial ADJ O
+thematic ADJ O
+analysis NOUN O
+[ X O
+37 NUM O
+] X O
+and CCONJ O
+subsequent ADJ O
+analysis NOUN O
+sensitised VERB O
+by ADP O
+the DET O
+Theoretical PROPN B-LF
+Framework PROPN I-LF
+of ADP I-LF
+Acceptability PROPN I-LF
+( PUNCT O
+TFA PROPN B-AC
+) PUNCT O
+[ X O
+38 NUM O
+] X O
+were AUX O
+undertaken VERB O
+. PUNCT O
+
+Two NUM O
+homologous ADJ O
+GTPases NOUN O
+, PUNCT O
+one NUM O
+in ADP O
+the DET O
+signal NOUN B-LF
+recognition NOUN I-LF
+particle NOUN I-LF
+( PUNCT O
+SRP PROPN B-AC
+) PUNCT O
+and CCONJ O
+one NUM O
+in ADP O
+the DET O
+SRP PROPN B-LF
+receptor NOUN I-LF
+( PUNCT O
+SR PROPN B-AC
+; PUNCT O
+called VERB O
+Ffh PROPN O
+and CCONJ O
+FtsY PROPN O
+in ADP O
+bacteria NOUN O
+, PUNCT O
+respectively ADV O
+) PUNCT O
+, PUNCT O
+mediate VERB O
+the DET O
+cotranslational ADJ O
+targeting NOUN O
+of ADP O
+membrane NOUN O
+and CCONJ O
+secretory NOUN O
+proteins NOUN O
+to ADP O
+the DET O
+eukaryotic ADJ O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT O
+ER PROPN B-AC
+) PUNCT O
+membrane NOUN O
+or CCONJ O
+the DET O
+bacterial ADJ O
+plasma NOUN O
+membrane NOUN O
+. PUNCT O
+
+- PUNCT O
+No DET O
+need NOUN O
+for ADP O
+" PUNCT O
+Basic PROPN B-LF
+Metabolic PROPN I-LF
+Panel PROPN I-LF
+[ PUNCT O
+BMP PROPN B-AC
+] PUNCT O
+: PUNCT O
+" PUNCT O
+, PUNCT O
+" PUNCT O
+Liver PROPN B-LF
+Function PROPN I-LF
+Test PROPN I-LF
+[ PUNCT O
+LFT PROPN B-AC
+] PUNCT O
+: PUNCT O
+" PUNCT O
+as SCONJ O
+the DET O
+details NOUN O
+are AUX O
+followed VERB O
+. PUNCT O
+
+Uric NOUN O
+acid NOUN O
+has AUX O
+been AUX O
+shown VERB O
+to ADP O
+associate VERB O
+with ADP O
+vascular ADJ O
+calcification NOUN O
+and CCONJ O
+with ADP O
+carotid ADJ B-LF
+intima NOUN I-LF
+- PUNCT I-LF
+media NOUN I-LF
+thickness NOUN I-LF
+( PUNCT O
+CIMT PROPN B-AC
+) PUNCT O
+and CCONJ O
+to ADP O
+suppress VERB O
+the DET O
+1 NUM O
+α NOUN O
+- PUNCT O
+hydroxylase NOUN O
+enzyme NOUN O
+leading VERB O
+to ADP O
+lower ADJ O
+1,25 NUM B-LF
+- PUNCT I-LF
+dihydroxyvitamin NOUN I-LF
+D PROPN I-LF
+( PUNCT O
+1,25(OH)2D NUM B-AC
+) PUNCT O
+and CCONJ O
+higher ADJ O
+intact ADJ B-LF
+parathyroid ADJ I-LF
+hormone NOUN I-LF
+( PUNCT O
+iPTH PROPN B-AC
+) PUNCT O
+levels NOUN O
+. PUNCT O
+
+Analysis NOUN O
+of ADP O
+pairwise ADJ O
+distances NOUN O
+showed VERB O
+that SCONJ O
+matK+rbcL+trnL NOUN B-LF
+- PUNCT I-LF
+F+trnH NOUN I-LF
+- PUNCT I-LF
+psbA+ITS NOUN I-LF
+( PUNCT O
+MRTPI NOUN B-AC
+) PUNCT O
+had VERB O
+the DET O
+greatest ADJ O
+value NOUN O
+and CCONJ O
+rbcL NOUN O
+the DET O
+least ADJ O
+. PUNCT O
+
+Body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI NOUN B-AC
+) PUNCT O
+was AUX O
+calculated VERB O
+as ADP O
+body NOUN O
+weight NOUN O
+( PUNCT O
+kg)/height NOUN O
+( PUNCT O
+m2 NOUN O
+) PUNCT O
+. PUNCT O
+
+Cytokines NOUN O
+and CCONJ O
+interferons NOUN O
+( PUNCT O
+all PRON O
+called VERB O
+cytokines NOUN O
+from ADP O
+here ADV O
+on ADV O
+) PUNCT O
+were AUX O
+determined VERB O
+in ADP O
+cell NOUN O
+culture NOUN O
+supernatants NOUN O
+from ADP O
+equine ADJ O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMC PROPN B-AC
+) PUNCT O
+using VERB O
+an DET O
+fluorescent ADJ O
+beads NOUN O
+- NOUN O
+based VERB O
+equine ADJ O
+cytokine NOUN O
+multiplex NOUN O
+assays NOUN O
+for ADP O
+IFN NOUN O
+- NOUN O
+α NOUN O
+, PUNCT O
+IL-4 NOUN B-AC
+, PUNCT O
+IL-10 NOUN O
+, PUNCT O
+IL-17 NOUN O
+and CCONJ O
+IFN NOUN B-AC
+- NOUN B-AC
+γ NOUN B-AC
+as SCONJ O
+previously ADV O
+described VERB O
+[ PUNCT O
+38 NUM O
+] PUNCT O
+. PUNCT O
+
+Study NOUN O
+villages NOUN O
+are AUX O
+shown VERB O
+with ADP O
+dark ADJ O
+brown ADJ O
+dots NOUN O
+; PUNCT O
+villages NOUN O
+with ADP O
+light ADJ B-LF
+trap NOUN I-LF
+captures NOUN I-LF
+( PUNCT O
+LTC PROPN B-AC
+) PUNCT O
+are AUX O
+marked VERB O
+with ADP O
+light ADJ O
+brown ADJ O
+dots NOUN O
+. PUNCT O
+
+The DET O
+HCP PROPN B-AC
+dataset NOUN O
+allowed VERB O
+us PRON O
+to ADP O
+investigate VERB O
+how SCONJ O
+the DET O
+magnitude NOUN O
+of ADP O
+the DET O
+brain NOUN O
+’s PART O
+global ADJ B-LF
+signal NOUN I-LF
+( PUNCT O
+GS PROPN B-AC
+) PUNCT O
+fluctuation NOUN O
+( PUNCT O
+also ADV O
+referred VERB O
+to ADP O
+as ADP O
+amplitude NOUN O
+in ADP O
+the DET O
+literature NOUN O
+) PUNCT O
+varies VERB O
+throughout ADP O
+the DET O
+day NOUN O
+. PUNCT O
+
+In ADP O
+the DET O
+NHIRD PROPN B-AC
+, PUNCT O
+disease NOUN O
+identification NOUN O
+is AUX O
+based VERB O
+on ADP O
+the DET O
+International PROPN B-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+, PUNCT I-LF
+9th ADJ I-LF
+Revision PROPN I-LF
+, PUNCT I-LF
+Clinical PROPN I-LF
+Modification PROPN I-LF
+( PUNCT O
+ICD-9 PROPN B-AC
+- PUNCT B-AC
+CM PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+was AUX O
+coded VERB O
+by ADP O
+a DET O
+qualified ADJ O
+clinician NOUN O
+according VERB O
+to ADP O
+the DET O
+clinical ADJ O
+assessment NOUN O
+, PUNCT O
+including VERB O
+disease NOUN O
+presentation NOUN O
+, PUNCT O
+physical ADJ O
+findings NOUN O
+and CCONJ O
+laboratory NOUN O
+tests NOUN O
+. PUNCT O
+
+We PRON O
+also ADV O
+examined VERB O
+the DET O
+role NOUN O
+of ADP O
+TNF PROPN B-LF
+Receptor PROPN I-LF
+Associated PROPN I-LF
+Factors PROPN I-LF
+( PUNCT O
+TRAF PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+regulation NOUN O
+of ADP O
+CX3CL1 PROPN O
+and CCONJ O
+TNF PROPN O
+- PUNCT O
+α NOUN O
+expression NOUN O
+. PUNCT O
+
+Se NOUN B-AC
+status NOUN O
+was AUX O
+determined VERB O
+by ADP O
+measuring VERB O
+both CCONJ O
+selenoprotein NOUN B-LF
+P NOUN I-LF
+( PUNCT O
+SePP PROPN B-AC
+) PUNCT O
+and CCONJ O
+plasma NOUN O
+Se NOUN B-AC
+concentrations NOUN O
+. PUNCT O
+
+The DET O
+underlying VERB O
+numerical ADJ O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+and CCONJ O
+S2 PROPN O
+Data NOUN O
+. PUNCT O
+3 NUM B-AC
+' NOUN B-AC
+UTR NOUN B-AC
+, PUNCT O
+3 NUM O
+' NOUN O
+untranslated VERB B-LF
+region NOUN I-LF
+; PUNCT O
+dpf NOUN B-AC
+, PUNCT O
+days NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT O
+F NOUN B-AC
+- NOUN B-AC
+actin NOUN B-AC
+, PUNCT O
+filamentous ADJ B-LF
+actin NOUN I-LF
+; PUNCT O
+smFISH PROPN B-AC
+, PUNCT O
+single ADJ B-LF
+molecule NOUN I-LF
+fluorescent ADJ I-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+. PUNCT O
+
+ASCVD NOUN B-AC
+, PUNCT O
+atherosclerotic ADJ B-LF
+cardiovascular ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+AUC PROPN B-AC
+, PUNCT O
+areas NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+; PUNCT O
+CACS PROPN B-AC
+, PUNCT O
+coronary ADJ B-LF
+artery NOUN I-LF
+calcium NOUN I-LF
+scores NOUN I-LF
+; PUNCT O
+CAP PROPN B-AC
+, PUNCT O
+calcified VERB B-LF
+plaque NOUN I-LF
+; PUNCT O
+NCAP PROPN B-AC
+, PUNCT O
+noncalcified ADJ B-LF
+plaque NOUN I-LF
+; PUNCT O
+MCAP PROPN B-AC
+, PUNCT O
+mixed VERB B-LF
+plaque NOUN I-LF
+. PUNCT O
+
+We PRON O
+initially ADV O
+observed VERB O
+that SCONJ O
+GCs NOUN B-AC
+migrate VERB O
+in ADP O
+chain NOUN O
+- PUNCT O
+like ADJ O
+structures NOUN O
+toward ADP O
+the DET O
+midbrain NOUN B-LF
+- PUNCT I-LF
+hindbrain NOUN I-LF
+boundary NOUN I-LF
+( PUNCT O
+MHB PROPN B-AC
+) PUNCT O
+. PUNCT O
+To PART O
+investigate VERB O
+these DET O
+cellular ADJ O
+interactions NOUN O
+in ADP O
+more ADJ O
+detail NOUN O
+, PUNCT O
+we PRON O
+first ADV O
+addressed VERB O
+whether SCONJ O
+glial ADJ O
+cells NOUN O
+are AUX O
+present ADJ O
+in ADP O
+the DET O
+zebrafish NOUN O
+cerebellum NOUN O
+and CCONJ O
+hindbrain NOUN O
+before ADP O
+and CCONJ O
+during ADP O
+onset NOUN O
+of ADP O
+GC NOUN B-AC
+migration NOUN O
+( PUNCT O
+36 NUM O
+hpf NOUN B-AC
+, PUNCT O
+48 NUM O
+hpf NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Other ADJ O
+interactions NOUN O
+occur VERB O
+with ADP O
+EGF PROPN B-AC
+( PUNCT O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+) PUNCT O
+and CCONJ O
+its PRON O
+respective ADJ O
+receptor NOUN O
+( PUNCT O
+EGFR PROPN B-AC
+) PUNCT O
+, PUNCT O
+CFTR PROPN B-AC
+( PUNCT O
+ATP NOUN O
+- PUNCT O
+binding VERB O
+cassette NOUN O
+sub NOUN O
+- PUNCT O
+family NOUN O
+C PROPN O
+, PUNCT O
+member NOUN O
+7 NUM O
+) PUNCT O
+, PUNCT O
+M6PR PROPN B-AC
+( PUNCT O
+mannose-6 NOUN O
+- PUNCT O
+phosphate NOUN O
+receptor NOUN O
+, PUNCT O
+cation NOUN O
+dependent ADJ O
+) PUNCT O
+, PUNCT O
+RAB5A PROPN B-AC
+( PUNCT O
+member NOUN B-LF
+RAS PROPN I-LF
+oncogene NOUN I-LF
+family NOUN I-LF
+) PUNCT O
+and CCONJ O
+APOB PROPN B-AC
+( PUNCT O
+apolipoprotein NOUN B-LF
+B NOUN I-LF
+) PUNCT O
+. PUNCT O
+
+PKA PROPN B-AC
+holoenzymes NOUN O
+, PUNCT O
+especially ADV O
+RII PROPN O
+holoenzymes NOUN O
+, PUNCT O
+typically ADV O
+bind VERB O
+with ADP O
+high ADJ O
+affinity NOUN O
+to ADP O
+an DET O
+amphipathic ADJ O
+helix NOUN O
+that PRON O
+is AUX O
+embedded VERB O
+in ADP O
+scaffold NOUN O
+proteins NOUN O
+referred VERB O
+to ADP O
+as ADP O
+A PROPN B-LF
+- PUNCT I-LF
+Kinase PROPN I-LF
+- PUNCT I-LF
+Anchoring PROPN I-LF
+Proteins PROPN I-LF
+( PUNCT O
+AKAPs PROPN B-AC
+) PUNCT O
+through ADP O
+their PRON O
+D NOUN B-AC
+/ SYM B-AC
+D NOUN B-AC
+domains NOUN O
+[ X O
+35–37 NUM O
+] PUNCT O
+. PUNCT O
+
+Cytology NOUN O
+results NOUN O
+were AUX O
+reported VERB O
+according VERB O
+to ADP O
+the DET O
+Bethesda PROPN O
+System PROPN O
+2001 NUM O
+and CCONJ O
+CC PROPN B-AC
+cases NOUN O
+were AUX O
+staged VERB O
+according VERB O
+to ADP O
+the DET O
+International PROPN B-LF
+Federation PROPN I-LF
+of ADP I-LF
+Gynecology PROPN I-LF
+and CCONJ I-LF
+Obstetrics PROPN I-LF
+( PUNCT O
+FIGO PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+To PART O
+address VERB O
+this DET O
+issue NOUN O
+, PUNCT O
+we PRON O
+utilized VERB O
+clockGAL4 PROPN O
+[ PUNCT O
+25 NUM O
+] PUNCT O
+, PUNCT O
+which PRON O
+drives VERB O
+broad ADJ O
+expression NOUN O
+among ADP O
+all DET O
+major ADJ O
+circadian ADJ O
+neuronal ADJ O
+groups NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+but CCONJ O
+relatively ADV O
+limited ADJ O
+noncircadian ADJ O
+expression NOUN O
+, PUNCT O
+including VERB O
+the DET O
+pars NOUN B-LF
+intercerebralis NOUN I-LF
+( PUNCT O
+PI PROPN B-AC
+) PUNCT O
+and CCONJ O
+cells NOUN O
+surrounding VERB O
+circadian ADJ O
+neurons NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to PART O
+directly ADV O
+visualize VERB O
+the DET O
+destabilization NOUN O
+dependent ADJ O
+on ADP O
+nucleotide NOUN O
+state NOUN O
+, PUNCT O
+we PRON O
+developed VERB O
+a DET O
+single ADJ O
+molecule NOUN O
+assay NOUN O
+using VERB O
+FtsZ PROPN O
+- PUNCT O
+YFP PROPN B-AC
+- PUNCT O
+mts NOUN B-AC
+incubated VERB O
+with ADP O
+fluorescently ADV O
+labeled VERB O
+nanobodies NOUN O
+( PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+[ SYM O
+GFP]-Booster PROPN B-AC
+- PUNCT O
+Atto647N PROPN O
+, PUNCT O
+see VERB O
+Materials NOUN O
+and CCONJ O
+methods NOUN O
+) PUNCT O
+( PUNCT O
+Fig NOUN O
+5A NOUN O
+) PUNCT O
+to PART O
+investigate VERB O
+the DET O
+protein NOUN O
+turnover NOUN O
+at ADP O
+the DET O
+membrane NOUN O
+, PUNCT O
+implying VERB O
+that SCONJ O
+faster ADJ O
+disassembly NOUN O
+suggests VERB O
+higher ADJ O
+destabilization NOUN O
+. PUNCT O
+
+Our PRON O
+large ADJ O
+sample NOUN O
+size NOUN O
+allowed VERB O
+us PRON O
+to ADP O
+calculate VERB O
+hazard NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+HRs NOUN B-AC
+) PUNCT O
+of ADP O
+mortality NOUN O
+and CCONJ O
+years NOUN O
+of ADP O
+life NOUN O
+gained VERB O
+after ADP O
+age NOUN O
+40 NUM O
+according VERB O
+to ADP O
+fine ADJ O
+gradations NOUN O
+of ADP O
+activity NOUN O
+levels NOUN O
+and CCONJ O
+in ADP O
+subgroups NOUN O
+for ADP O
+which PRON O
+, PUNCT O
+to ADP O
+our PRON O
+knowledge NOUN O
+, PUNCT O
+no DET O
+prior ADJ O
+estimates NOUN O
+are AUX O
+available ADJ O
+, PUNCT O
+such ADJ O
+as ADP O
+black ADJ O
+individuals NOUN O
+, PUNCT O
+smokers NOUN O
+, PUNCT O
+and CCONJ O
+persons NOUN O
+with ADP O
+a DET O
+history NOUN O
+of ADP O
+cancer NOUN O
+and/or CCONJ O
+heart NOUN O
+disease NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+8 NUM B-AC
+- NOUN B-AC
+OHdG NOUN B-AC
+: PUNCT O
+8 NUM O
+- NOUN O
+hydroxy-2′-deoxyguanosine NOUN O
+; PUNCT O
+8 NUM O
+- NOUN O
+iso NOUN B-AC
+- NOUN B-AC
+PGF2a NOUN B-AC
+: PUNCT O
+8 NUM O
+- NOUN O
+iso NOUN O
+- NOUN O
+prostaglandin NOUN O
+F2a NOUN O
+; PUNCT O
+MDA NOUN B-AC
+: PUNCT O
+malondialdehyde NOUN B-LF
+; PUNCT O
+6 NUM B-AC
+- NOUN B-AC
+CN NOUN B-AC
+: PUNCT O
+6 NUM B-LF
+- NOUN I-LF
+chloronicotinic ADJ I-LF
+acid NOUN I-LF
+; PUNCT O
+CI NOUN O
+: PUNCT O
+confidence NOUN O
+interval NOUN O
+
+We PRON O
+investigated VERB O
+the DET O
+participation NOUN O
+of ADP O
+mitogen NOUN O
+- PUNCT O
+activated VERB O
+protein NOUN O
+kinase NOUN O
+kinase NOUN O
+( PUNCT O
+MEK PROPN B-AC
+) PUNCT O
+kinase NOUN O
+1 NUM O
+( PUNCT O
+MEKK1)/MEK1 PROPN B-AC
+/ SYM O
+ERK1 PROPN O
+/ SYM O
+GLI-1/2 PROPN O
+and CCONJ O
+activator NOUN B-LF
+protein-1 NOUN I-LF
+( PUNCT O
+AP-1 PROPN B-AC
+) PUNCT O
+signaling NOUN O
+in ADP O
+hypoxia NOUN O
+- PUNCT O
+induced VERB O
+CTGF PROPN B-AC
+expression NOUN O
+in ADP O
+human ADJ O
+lung NOUN O
+fibroblasts NOUN O
+. PUNCT O
+
+HFD PROPN B-AC
+stands VERB O
+for ADP O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+we PRON O
+performed VERB O
+a DET O
+FTIR PROPN B-AC
+investigation NOUN O
+on ADP O
+paraffin NOUN O
+sections NOUN O
+of ADP O
+human ADJ O
+hands NOUN O
+by ADP O
+principle ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCA NOUN B-AC
+) PUNCT O
+in ADP O
+order NOUN O
+to PART O
+determine VERB O
+variance NOUN O
+of ADP O
+protein NOUN O
+structures NOUN O
+between ADP O
+electrical ADJ O
+mark NOUN O
+and CCONJ O
+normal ADJ O
+skin NOUN O
+. PUNCT O
+
+D NOUN B-AC
+/ SYM B-AC
+R NOUN B-AC
+, PUNCT O
+dangerous ADJ B-LF
+and CCONJ I-LF
+rich ADJ I-LF
+; PUNCT O
+ITI NOUN O
+, PUNCT O
+intertrial ADJ O
+interval NOUN O
+; PUNCT O
+S NOUN B-AC
+/ SYM B-AC
+P NOUN B-AC
+, PUNCT O
+safe ADJ B-LF
+and CCONJ I-LF
+poor ADJ I-LF
+; PUNCT O
+S NOUN B-AC
+/ SYM B-AC
+R NOUN B-AC
+, PUNCT O
+safe ADJ B-LF
+and CCONJ I-LF
+rich ADJ I-LF
+. PUNCT O
+
+We PRON O
+used VERB O
+the DET O
+data NOUN O
+from ADP O
+the DET O
+cluster NOUN O
+- PUNCT O
+randomized VERB O
+cross ADJ O
+- PUNCT O
+sectional ADJ O
+Endoscopic PROPN B-LF
+Quality PROPN I-LF
+Improvement PROPN I-LF
+Program-3 PROPN I-LF
+( PUNCT O
+EQUIP-3 PROPN B-AC
+) PUNCT O
+study NOUN O
+( PUNCT O
+Clinical PROPN O
+Trials PROPN O
+Registration PROPN O
+: PUNCT O
+NCT02325635 NUM O
+) PUNCT O
+that PRON O
+ran VERB O
+from ADP O
+September PROPN O
+2013 NUM O
+until ADP O
+January PROPN O
+2015.[9 NUM O
+] PUNCT O
+The DET O
+EQUIP-3 PROPN B-AC
+study NOUN O
+was AUX O
+approved VERB O
+by ADP O
+the DET O
+Mayo PROPN O
+Clinic PROPN O
+Institutional PROPN O
+Review PROPN O
+Board PROPN O
+and CCONJ O
+was AUX O
+considered VERB O
+minimal ADJ O
+risk NOUN O
+and CCONJ O
+exempt ADJ O
+from ADP O
+patient NOUN O
+- PUNCT O
+level NOUN O
+consent.[9 NOUN O
+] PUNCT O
+In ADP O
+the DET O
+EQUIP-3 PROPN B-AC
+study NOUN O
+centers NOUN O
+were AUX O
+randomized VERB O
+, PUNCT O
+after ADP O
+a DET O
+lead VERB O
+- PUNCT O
+in ADP O
+phase NOUN O
+, PUNCT O
+to PART O
+receive VERB O
+a DET O
+quality NOUN O
+improvement NOUN O
+program NOUN O
+aimed VERB O
+at ADP O
+increasing VERB O
+the DET O
+ADR PROPN B-AC
+or CCONJ O
+no DET O
+intervention NOUN O
+. PUNCT O
+
+Intracranial ADJ B-LF
+pressure NOUN I-LF
+( PUNCT O
+ICP PROPN B-AC
+) PUNCT O
+monitoring NOUN O
+is AUX O
+necessary ADJ O
+in ADP O
+many ADJ O
+clinical ADJ O
+scenarios NOUN O
+. PUNCT O
+
+Prostate NOUN B-LF
+cancer NOUN I-LF
+( PUNCT O
+PCa NOUN B-AC
+) PUNCT O
+poses VERB O
+a DET O
+major ADJ O
+health NOUN O
+concern NOUN O
+in ADP O
+men NOUN O
+worldwide ADV O
+. PUNCT O
+
+This DET O
+score NOUN O
+was AUX O
+called VERB O
+the DET O
+Perturbation PROPN B-LF
+Score PROPN I-LF
+( PUNCT O
+PS PROPN B-AC
+; PUNCT O
+PScp PROPN O
+, PUNCT O
+d NOUN O
+being AUX O
+the DET O
+perturbation NOUN O
+experimented VERB O
+by ADP O
+pathway NOUN O
+p NOUN O
+during ADP O
+the DET O
+manifestation NOUN O
+of ADP O
+disease NOUN O
+d NOUN O
+on ADP O
+cell NOUN O
+type NOUN O
+c NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+Charlson PROPN B-LF
+Comorbidity PROPN I-LF
+Index PROPN I-LF
+( PUNCT O
+CCI PROPN B-AC
+) PUNCT O
+was AUX O
+calculated VERB O
+electronically.[22 PUNCT O
+] PUNCT O
+Sepsis NOUN O
+was AUX O
+identified VERB O
+using VERB O
+a DET O
+previously ADV O
+- PUNCT O
+validated VERB O
+electronic ADJ O
+algorithm.[23 NOUN O
+] PUNCT O
+Relevant ADJ O
+cardiovascular ADJ O
+hospital NOUN O
+discharge NOUN O
+diagnoses NOUN O
+were AUX O
+determined VERB O
+using VERB O
+ICD-9 PROPN O
+diagnostic ADJ O
+codes NOUN O
+. PUNCT O
+
+To PART O
+converge VERB O
+on ADP O
+stable ADJ O
+model NOUN O
+output NOUN O
+, PUNCT O
+we PRON O
+run VERB O
+a DET O
+simulated VERB O
+cohort NOUN O
+of ADP O
+1 NUM O
+million NUM O
+patients NOUN O
+infected VERB O
+with ADP O
+HIV PROPN O
+. PUNCT O
+Because SCONJ O
+the DET O
+cohort NOUN O
+size NOUN O
+can AUX O
+be AUX O
+varied VERB O
+in ADP O
+the DET O
+simulation NOUN O
+— PUNCT O
+i.e. X O
+, PUNCT O
+we PRON O
+might AUX O
+also ADV O
+simulate VERB O
+2 NUM O
+million NUM O
+or CCONJ O
+5 NUM O
+million NUM O
+patients—95 NOUN O
+% NOUN O
+confidence NOUN O
+intervals NOUN O
+and CCONJ O
+standard ADJ B-LF
+deviations NOUN I-LF
+( PUNCT O
+SDs NOUN B-AC
+) PUNCT O
+do AUX O
+not PART O
+adequately ADV O
+capture VERB O
+uncertainty NOUN O
+in ADP O
+simulation NOUN O
+modeling NOUN O
+. PUNCT O
+
+LRI NOUN B-AC
+, PUNCT O
+lower ADJ B-LF
+respiratory ADJ I-LF
+infection NOUN I-LF
+. PUNCT O
+
+FWP PROPN B-AC
+mechanism NOUN O
+of ADP O
+action NOUN O
+could AUX O
+possibly ADV O
+be AUX O
+mediated VERB O
+by ADP O
+an DET O
+elevation NOUN O
+of ADP O
+GSH PROPN O
+concentration NOUN O
+and CCONJ O
+a DET O
+decreased VERB O
+glutathione NOUN B-LF
+redox NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+GSSG NOUN B-AC
+/ SYM B-AC
+GSH PROPN B-AC
+) PUNCT O
+ratio NOUN O
+which PRON O
+leads VERB O
+to ADP O
+a DET O
+suppression NOUN O
+of ADP O
+OxS PROPN B-AC
+and CCONJ O
+the DET O
+decreased VERB O
+release NOUN O
+of ADP O
+8 NUM B-AC
+- PUNCT B-AC
+EPI NOUN B-AC
+. PUNCT O
+Hydrolyzed VERB O
+whey NOUN O
+protein NOUN O
+isolate NOUN O
+can AUX O
+increase VERB O
+intracellular ADJ O
+glutathione NOUN O
+level NOUN O
+in ADP O
+human ADJ O
+prostate NOUN O
+epithelial ADJ O
+cell NOUN O
+line NOUN O
+and CCONJ O
+protect VERB O
+form NOUN O
+oxidant NOUN O
+induced VERB O
+cell NOUN O
+death[16 NOUN O
+] PUNCT O
+. PUNCT O
+
+Twenty NUM O
+- PUNCT O
+one NUM O
+studies NOUN O
+( PUNCT O
+44 NUM O
+% PUNCT O
+) PUNCT O
+analyzed VERB O
+birthweight NOUN O
+, PUNCT O
+low ADJ B-LF
+birthweight NOUN I-LF
+( PUNCT O
+LBW PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+small ADJ O
+for ADP O
+gestational ADJ O
+age NOUN O
+. PUNCT O
+