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README.md
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---
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ScVI is a variational inference model for single-cell RNA-seq data that can learn an underlying
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latent space, integrate technical batches and impute dropouts.
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The learned low-dimensional latent representation of the data can be used for visualization and
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clustering.
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scVI takes as input a scRNA-seq gene expression matrix with cells and genes.
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We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_guide/models/scvi.html).
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- See our original manuscript for further details of the model:
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[scVI manuscript](https://www.nature.com/articles/s41592-018-0229-2).
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- See our manuscript on [scvi-hub](https://www.biorxiv.org/content/10.1101/2024.03.01.582887v2) how
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to leverage pre-trained models.
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This model can be used for fine tuning on new data using our Arches framework:
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[Arches tutorial](https://docs.scvi-tools.org/en/1.0.0/tutorials/notebooks/scarches_scvi_tools.html).
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# Model Description
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scVI model trained on synthetic IID data and uploaded with the full training data.
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#
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We provide here key performance metrics for the uploaded model, if provided by the data uploader.
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<details>
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<summary><strong>Coefficient of variation</strong></summary>
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The cell-wise coefficient of variation summarizes how well variation between different cells is
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preserved by the generated model expression. Below a squared Pearson correlation coefficient of 0.4
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, we would recommend not to use generated data for downstream analysis, while the generated latent
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space might still be useful for analysis.
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**Cell-wise Coefficient of Variation**:
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| Metric | Training Value | Validation Value |
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|-------------------------|----------------|------------------|
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| Mean Absolute Error | 0.99 | 1.03 |
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| Pearson Correlation | -0.07 | -0.20 |
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| Spearman Correlation | -0.07 | -0.03 |
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| R² (R-Squared) | -14.43 | -12.71 |
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The gene-wise coefficient of variation summarizes how well variation between different genes is
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preserved by the generated model expression. This value is usually quite high.
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**Gene-wise Coefficient of Variation**:
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| Metric | Training Value |
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| Mean Absolute Error | 1.07 |
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| Pearson Correlation | -0.12 |
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| Spearman Correlation | -0.00 |
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| R² (R-Squared) | -2.15 |
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</details>
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<details>
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<summary><strong>Differential expression metric</strong></summary>
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The differential expression metric provides a summary of the differential expression analysis
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between cell types or input clusters. We provide here the F1-score, Pearson Correlation
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Coefficient of Log-Foldchanges, Spearman Correlation Coefficient, and Area Under the Precision
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Recall Curve (AUPRC) for the differential expression analysis using Wilcoxon Rank Sum test for each
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cell-type.
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**Differential expression**:
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| Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
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| --- | --- | --- | --- | --- | --- | --- | --- |
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| 0 | 1.00 | 0.90 | 0.06 | 0.05 | 0.47 | 0.34 | 50.00 |
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| 1 | 1.00 | 0.94 | -0.10 | -0.10 | 0.34 | 0.16 | 48.00 |
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| 2 | 1.00 | 0.94 | -0.02 | -0.03 | 0.53 | 0.37 | 41.00 |
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| 3 | 1.00 | 0.82 | 0.17 | 0.15 | 0.56 | 0.36 | 39.00 |
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| 4 | 1.00 | 0.99 | 0.03 | -0.02 | 0.34 | 0.16 | 37.00 |
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| 5 | 1.00 | 0.95 | 0.07 | 0.04 | 0.64 | 0.36 | 37.00 |
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| 6 | 1.00 | 1.04 | -0.14 | -0.15 | 0.48 | 0.23 | 32.00 |
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| 7 | 1.00 | 1.01 | 0.14 | 0.13 | 0.52 | 0.19 | 31.00 |
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| 8 | 1.00 | 0.99 | 0.04 | 0.07 | 0.54 | 0.23 | 28.00 |
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| 9 | 1.00 | 1.09 | 0.05 | 0.04 | 0.45 | 0.28 | 26.00 |
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| 10 | 1.00 | 1.21 | 0.09 | 0.10 | 0.54 | 0.24 | 19.00 |
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| 11 | 1.00 | 1.97 | -0.01 | -0.08 | 0.53 | 0.32 | 12.00 |
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</details>
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# Model Properties
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<summary><strong>Model Parameters</strong></summary>
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These provide the settings to setup the original model:
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```json
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{
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"n_hidden": 128,
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```
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<details>
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<summary><strong>Setup Data Arguments</strong></summary>
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Arguments passed to setup_anndata of the original model:
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```json
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{
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"layer": null,
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```
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<details>
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<summary><strong>Data Registry</strong></summary>
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Registry elements for AnnData manager:
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| Registry Key | scvi-tools Location |
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| X | adata.X |
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| batch | adata.obs['_scvi_batch'] |
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| labels | adata.obs['_scvi_labels'] |
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- **Data is Minified**: False
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</details>
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<details>
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<summary><strong>Summary Statistics</strong></summary>
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| Summary Stat Key | Value |
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|--------------------------|-------|
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| n_batch | 1 |
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| n_labels | 1 |
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| n_vars | 100 |
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<!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make
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sure to provide this field if you want users to be able to access your training data. See the
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scvi-tools documentation for details. -->
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**Training data url**: Not provided by uploader
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training process, the code is available at the link below.
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# References
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To be added...
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# Description
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scVI model trained on synthetic IID data and uploaded with the full training data.
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# Model properties
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Many model properties are in the model tags. Some more are listed below.
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**model_init_params**:
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```json
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{
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"n_hidden": 128,
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}
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```
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**model_setup_anndata_args**:
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```json
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{
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"layer": null,
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}
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```
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**model_summary_stats**:
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| Summary Stat Key | Value |
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|--------------------------|-------|
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| n_batch | 1 |
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| n_labels | 1 |
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| n_vars | 100 |
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**model_data_registry**:
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| Registry Key | scvi-tools Location |
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|--------------|---------------------------|
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| X | adata.X |
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| batch | adata.obs['_scvi_batch'] |
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| labels | adata.obs['_scvi_labels'] |
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**model_parent_module**: scvi.model
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**data_is_minified**: False
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# Training data
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This is an optional link to where the training data is stored if it is too large
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to host on the huggingface Model hub.
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<!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make
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sure to provide this field if you want users to be able to access your training data. See the
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scvi-tools documentation for details. -->
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Training data url: N/A
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# Training code
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This is an optional link to the code used to train the model.
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Training code url: N/A
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# References
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To be added...
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