AchilleSoulieID commited on
Commit
172390e
Β·
1 Parent(s): 3886d2a

tune down cursor

Browse files
Files changed (1) hide show
  1. folding_studio_demo/app.py +16 -13
folding_studio_demo/app.py CHANGED
@@ -275,26 +275,27 @@ def model_comparison(api_key: str) -> None:
275
 
276
 
277
  def create_antibody_discovery_tab():
278
- gr.Markdown("# Accelerating Antibody Discovery: In-Silico and Experimental Insights")
 
 
279
  gr.Markdown("""
280
- Hey there! πŸ‘‹ Let's dive into how we're using AI to accelerate antibody drug discovery by looking at how protein folding models stack up against real lab data.
281
 
282
- We've got this fascinating dataset that shows how well different antibodies stick to a specific target (we measure this as KD in nM). πŸ§ͺ
283
  For each antibody-target pair, we've recorded:
284
- - The antibody's light and heavy chain sequences (think of them as the antibody's building blocks) 🧬
285
- - The target (antigen) sequence 🎯
286
- - How strongly they bind together in the lab (the KD value, lower means stronger binding) πŸ’ͺ
287
 
288
- Here's where it gets interesting! We take these sequences and feed them into protein folding models
289
  that predict their 3D structures. The models tell us how confident they are about their predictions.
290
  By comparing these confidence scores with our lab results, we can figure out which model scores
291
- are actually good at predicting real binding strength! 🎯
292
 
293
- Why is this exciting for drug discovery? πŸš€ Once we know which computational scores to trust,
294
  we can use them to quickly check thousands of potential antibodies without having to test each one
295
- in the lab. It's like having a high-speed screening tool! We can then focus our lab work on testing
296
- just the most promising candidates. This means we can find effective antibody drugs much faster than
297
- before! πŸ”¬βœ¨
298
  """)
299
  spr_data_with_scores = pd.read_csv("spr_af_scores_mapped.csv")
300
  spr_data_with_scores = spr_data_with_scores.rename(columns=SCORE_COLUMN_NAMES)
@@ -323,7 +324,9 @@ def create_antibody_discovery_tab():
323
 
324
  with gr.Row():
325
  with gr.Column(min_width=150):
326
- gr.Markdown("Now, let's see how well the protein folding models can predict the binding affinity of these antibodies to the target antigen.")
 
 
327
  with gr.Column(min_width=150):
328
  fake_predict_btn = gr.Button(
329
  "Predict structures of all complexes",
 
275
 
276
 
277
  def create_antibody_discovery_tab():
278
+ gr.Markdown(
279
+ "# Accelerating Antibody Discovery: In-Silico and Experimental Insights"
280
+ )
281
  gr.Markdown("""
282
+ Let's dive into how we're using AI to accelerate antibody drug discovery by looking at how protein folding models stack up against real lab data.
283
 
284
+ We've got this dataset that shows how well different antibodies stick to a specific target (we measure this as KD in nM).
285
  For each antibody-target pair, we've recorded:
286
+ - The antibody's light and heavy chain sequences (think of them as the antibody's building blocks)
287
+ - The target (antigen) sequence
288
+ - How strongly they bind together in the lab (the KD value, lower means stronger binding)
289
 
290
+ Why is it interesting? We take these sequences and feed them into protein folding models
291
  that predict their 3D structures. The models tell us how confident they are about their predictions.
292
  By comparing these confidence scores with our lab results, we can figure out which model scores
293
+ are actually good at predicting real binding strength!
294
 
295
+ Why is this useful for drug discovery? Once we know which computational scores to trust,
296
  we can use them to quickly check thousands of potential antibodies without having to test each one
297
+ in the lab. We can then focus our lab work on testing just the most promising candidates.
298
+ This means we can find effective antibody drugs much faster than before!
 
299
  """)
300
  spr_data_with_scores = pd.read_csv("spr_af_scores_mapped.csv")
301
  spr_data_with_scores = spr_data_with_scores.rename(columns=SCORE_COLUMN_NAMES)
 
324
 
325
  with gr.Row():
326
  with gr.Column(min_width=150):
327
+ gr.Markdown(
328
+ "Now, let's see how well the protein folding models can predict the binding affinity of these antibodies to the target antigen."
329
+ )
330
  with gr.Column(min_width=150):
331
  fake_predict_btn = gr.Button(
332
  "Predict structures of all complexes",