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{
"cells": [
{
"cell_type": "code",
"execution_count": 1,
"metadata": {},
"outputs": [
{
"name": "stderr",
"output_type": "stream",
"text": [
"/Users/satoc/miniforge3/envs/gradio/lib/python3.12/site-packages/sentence_transformers/cross_encoder/CrossEncoder.py:13: TqdmExperimentalWarning: Using `tqdm.autonotebook.tqdm` in notebook mode. Use `tqdm.tqdm` instead to force console mode (e.g. in jupyter console)\n",
" from tqdm.autonotebook import tqdm, trange\n"
]
}
],
"source": [
"from OpenAITools.JRCTTools import DfPostProcess, get_matched_df\n",
"from sentence_transformers import SentenceTransformer, util\n",
"import pandas as pd"
]
},
{
"cell_type": "code",
"execution_count": 2,
"metadata": {},
"outputs": [
{
"name": "stderr",
"output_type": "stream",
"text": [
"/Users/satoc/miniforge3/envs/gradio/lib/python3.12/site-packages/transformers/tokenization_utils_base.py:1617: FutureWarning: `clean_up_tokenization_spaces` was not set. It will be set to `True` by default. This behavior will be deprecated in transformers v4.45, and will be then set to `False` by default. For more details check this issue: https://github.com/huggingface/transformers/issues/31884\n",
" warnings.warn(\n"
]
}
],
"source": [
"exclusive_words = [\"triple negative\", \"double positive\",\"Malignant\",\"recurrent\",\"IDH wild-type\", \"High-Grade\", \"Low-grade\"]\n",
"csv_loc = '../ClinicalTrialCSV/JRCT20241215Cancer.csv'\n",
"df = pd.read_csv(csv_loc, index_col=0)\n",
"# モデルのロード\n",
"model = SentenceTransformer('pritamdeka/S-PubMedBert-MS-MARCO')\n"
]
},
{
"cell_type": "code",
"execution_count": 4,
"metadata": {},
"outputs": [],
"source": [
"#processed_df = DfPostProcess(exclusive_words, model, csv_loc=csv_loc)\n",
"processed_df = DfPostProcess(exclusive_words, model, dataframe=df)"
]
},
{
"cell_type": "code",
"execution_count": 4,
"metadata": {},
"outputs": [],
"source": [
"processed_df.to_csv(\"../ClinicalTrialCSV/JRCT20241215CancerPost.csv\")"
]
},
{
"cell_type": "code",
"execution_count": 16,
"metadata": {},
"outputs": [],
"source": [
"def get_matched_df(basedf, query, model, threshold=0.5):\n",
" # queryをベクトル化（テンソル化）しCPUへ移動\n",
" query_vec = model.encode(query, convert_to_tensor=True).cpu()\n",
"\n",
" matched_indices = []\n",
" for idx, target_vec_str in enumerate(basedf['TargetVec']):\n",
" # CSVから読み込んだ時点でTargetVecはPythonリストを文字列化したものになっているため、\n",
" # ここでliteral_evalでリストに戻します。\n",
" if isinstance(target_vec_str, str):\n",
" # target_vec_strは\"[[...], [...]]\"のようなリスト形式\n",
" target_list = ast.literal_eval(target_vec_str) # リストに変換\n",
" target_vecs = torch.tensor(target_list) # リストからTensorへ\n",
" else:\n",
" # 万が一既にTensorの場合はそのまま使用\n",
" target_vecs = target_vec_str\n",
"\n",
" # 必要であればCPUへ移動（通常はすでにCPU上のはず）\n",
" \"\"\"if target_vecs[0].is_cuda:\n",
" target_vecs = target_vecs.cpu()\"\"\"\n",
"\n",
" # コサイン類似度を計算\n",
" cosine_scores = util.cos_sim(query_vec, target_vecs).squeeze()\n",
"\n",
" # thresholdを超えるスコアが1つでもあればマッチと判断\n",
" if (cosine_scores >= threshold).any():\n",
" matched_indices.append(idx)\n",
"\n",
" # 条件を満たした行を抽出\n",
" matched_df = basedf.iloc[matched_indices]\n",
" return matched_df"
]
},
{
"cell_type": "code",
"execution_count": 17,
"metadata": {},
"outputs": [
{
"data": {
"text/plain": [
"[[-0.12602144479751587,\n",
" -0.7141546607017517,\n",
" -0.4860573410987854,\n",
" -0.6787610650062561,\n",
" -0.5019499659538269,\n",
" -0.13430769741535187,\n",
" -0.6577554941177368,\n",
" 0.6076976656913757,\n",
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]
},
"execution_count": 17,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"processed_df['TargetVec'][0]"
]
},
{
"cell_type": "code",
"execution_count": 18,
"metadata": {},
"outputs": [
{
"data": {
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" <th></th>\n",
" <th>JRCT ID</th>\n",
" <th>NCT No</th>\n",
" <th>JapicCTI No</th>\n",
" <th>Title</th>\n",
" <th>TargetJ</th>\n",
" <th>Target</th>\n",
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" <th>研究・治験の目的</th>\n",
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" <th>31</th>\n",
" <td>jRCT2061240081</td>\n",
" <td>NCT06393374</td>\n",
" <td>NaN</td>\n",
" <td>術前薬物療法後の手術時に病理学的完全奏効を達成していないトリプルネガティブ乳癌患者を対象に、...</td>\n",
" <td>トリプルネガティブ乳癌</td>\n",
" <td>トリプルネガティブ乳癌</td>\n",
" <td>Triple negative breast cancer</td>\n",
" <td>術前薬物療法後の手術時に病理学的完全奏効を達成していないトリプルネガティブ乳癌患者を対象に、...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>-Has centrally confirmed TNBC, as defined by t...</td>\n",
" <td>-Has a known germline breast cancer gene (BRCA...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>-Arm 1: MK-2870 4mg/kg intravenous (IV) every ...</td>\n",
" <td>[Triple Negative, Breast Cancer]</td>\n",
" <td>[[-0.21876227855682373, -0.4577382504940033, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>32</th>\n",
" <td>jRCT2031240476</td>\n",
" <td>NCT06312176</td>\n",
" <td>NaN</td>\n",
" <td>ホルモン受容体陽性・ヒト上皮成長因子受容体2陰性（HR+/HER2-）の切除不能な局所進行又...</td>\n",
" <td>HR+/HER2-の切除不能局所進行又は転移性乳癌の患者</td>\n",
" <td>HR+/HER2-の切除不能局所進行又は転移性乳癌の患者</td>\n",
" <td>HR+/HER2 unresectable locally advanced or meta...</td>\n",
" <td>HR+/HER2-の切除不能な局所進行又は転移性乳癌患者を対象にMK-2870の単剤及びペム...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>-Has unresectable locally advanced or metastat...</td>\n",
" <td>-Has breast cancer amenable to treatment with ...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Arm A:MK-2870 Participants receive 4 mg/kg of ...</td>\n",
" <td>[Hr+/Her2 Unresectable Locally Advanced, Metas...</td>\n",
" <td>[[0.04888693988323212, -0.7584289908409119, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>157</th>\n",
" <td>jRCT2052240059</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>遺伝子HSD17B4高メチル化を有するHER2陽性ER陰性乳癌における非手術療法の有用性を評...</td>\n",
" <td>乳がん</td>\n",
" <td>乳がん</td>\n",
" <td>Breast cancer</td>\n",
" <td>HSD17B4高メチル化(HSD17B4 hypermethylation:HH)を有するH...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1. Histologically confirmed invasive breast ca...</td>\n",
" <td>1. History of other malignancy within the last...</td>\n",
" <td>20age old over</td>\n",
" <td>No limit</td>\n",
" <td>Female</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Omitting breast surgery after preoperative che...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>170</th>\n",
" <td>jRCT2031240096</td>\n",
" <td>NCT06380751</td>\n",
" <td>NaN</td>\n",
" <td>本治験の主要目的は、BRCA1、BRCA2 又は PALB2 変異を有し、HR 陽性、HER...</td>\n",
" <td>進行乳癌</td>\n",
" <td>進行乳癌</td>\n",
" <td>Advanced Breast Cancer</td>\n",
" <td>Treatment</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Adult females, pre/peri-menopausal and/or po...</td>\n",
" <td>- Participants with history of MDS/AML or with...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Experimental: Arm 1: saruparib (AZD5305) plus ...</td>\n",
" <td>[Advanced Breast Cancer]</td>\n",
" <td>[[-0.21163925528526306, -0.5019860863685608, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>209</th>\n",
" <td>jRCT2031230750</td>\n",
" <td>NCT06188559</td>\n",
" <td>NaN</td>\n",
" <td>治療歴のある HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌の被験者を対象に，...</td>\n",
" <td>HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌</td>\n",
" <td>HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌</td>\n",
" <td>HER2-positive or HER2-low unresectable or meta...</td>\n",
" <td>治療</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>(1) Male or female, aged >=18 years at the tim...</td>\n",
" <td>(1) Presence of brain or subdural metastases, ...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Generic Name:NA Study Treatment in dose optimi...</td>\n",
" <td>[Her2-Positive, Her2-Low Unresectable, Metasta...</td>\n",
" <td>[[-0.08892004191875458, -0.8978654146194458, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>215</th>\n",
" <td>jRCT2031230723</td>\n",
" <td>NCT06112379</td>\n",
" <td>NaN</td>\n",
" <td>未治療のトリプルネガティブ又はホルモン受容体低発現／HER2陰性乳癌の成人患者を対象として、...</td>\n",
" <td>乳癌</td>\n",
" <td>乳癌</td>\n",
" <td>Breast Cancer</td>\n",
" <td>未治療のトリプルネガティブ又はホルモン受容体低発現/HER2陰性乳癌の成人患者を対象として、...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1. Participant must be >= 18 years at the time...</td>\n",
" <td>1. As judged by the investigator, any evidence...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>- Experimental arm: Dato-DXd plus durvalumab n...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>224</th>\n",
" <td>jRCT2051230196</td>\n",
" <td>NCT06105632</td>\n",
" <td>NaN</td>\n",
" <td>CDK4/6 阻害薬による前治療で進行したホルモン受容体陽性HER2 陰性の進行または転移乳...</td>\n",
" <td>ホルモン受容体（HR）陽性ヒト上皮増殖因子受容体2（HER2）陰性の進行または転移乳癌</td>\n",
" <td>ホルモン受容体(HR)陽性ヒト上皮増殖因子受容体2(HER2)陰性の進行または転移乳癌</td>\n",
" <td>HR-positive, HER2-negative Advanced or Metasta...</td>\n",
" <td>CDK4/6阻害薬による前治療で進行したHR陽性HER2陰性の進行または転移乳癌患者を対象に...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>* Histological confirmation of breast cancer w...</td>\n",
" <td>* Any medical or psychiatric condition that ma...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Arm A (Experimental Arm) PF-07220060 plus Fulv...</td>\n",
" <td>[Hr-Positive, Her2-Negative Advanced, Metastat...</td>\n",
" <td>[[-0.083187997341156, -0.7571865916252136, -0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>234</th>\n",
" <td>jRCT2031230677</td>\n",
" <td>NCT06206837</td>\n",
" <td>NaN</td>\n",
" <td>18歳以上のER陽性／HER2陰性の進行または転移乳癌患者を対象として，経口タンパク質分解誘...</td>\n",
" <td>エストロゲン受容体陽性／ヒト上皮増殖因子受容体 2 陰性の進行または転移乳癌</td>\n",
" <td>エストロゲン受容体陽性/ヒト上皮増殖因子受容体 2 陰性の進行または転移乳癌</td>\n",
" <td>ER+/HER2- advanced or metastatic breast cancer</td>\n",
" <td>進行乳癌患者を対象として,vepdegestrantとPF-07220060を併用投与したと...</td>\n",
" <td>1-2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Inclusion Criteria: * Histological or cytologi...</td>\n",
" <td>Exclusion Criteria: * visceral crisis at risk ...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Drug: vepdegestrant Daily oral dosages of vepd...</td>\n",
" <td>[Er+/Her2- Advanced, Metastatic Breast Cancer]</td>\n",
" <td>[[-0.154923215508461, -0.39443543553352356, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>240</th>\n",
" <td>jRCT2061230102</td>\n",
" <td>NCT06103864</td>\n",
" <td>NaN</td>\n",
" <td>Programmed death-ligand（PD-L1）陽性の局所再発手術不能又は転移性...</td>\n",
" <td>乳癌</td>\n",
" <td>乳癌</td>\n",
" <td>Breast Cancer</td>\n",
" <td>PD-L1陽性の局所再発手術不能または転移性TNBC患者を対象に、デュルバルマブ併用または非...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Histologically or cytologically documented loc...</td>\n",
" <td>As judged by investigator, severe or uncontrol...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Arm 1: Dato-DXd + durvalumab Arm 2: Investigat...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>307</th>\n",
" <td>jRCT2061230074</td>\n",
" <td>NCT05952557</td>\n",
" <td>NaN</td>\n",
" <td>根治的局所治療（化学療法の併用または非併用）を受けて疾患の兆候のない、再発リスクが中間～高リ...</td>\n",
" <td>乳がん、早期乳がん</td>\n",
" <td>乳がん、早期乳がん</td>\n",
" <td>Breast Cancer, Early Breast Cancer</td>\n",
" <td>Treatment</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Women and Men; 18 years or more at the time ...</td>\n",
" <td>- Inoperable locally advanced or metastatic br...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>arm A: continue with SoC ET as directed by inv...</td>\n",
" <td>[Breast Cancer, Early Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>342</th>\n",
" <td>jRCT2051230094</td>\n",
" <td>NCT05794906</td>\n",
" <td>NaN</td>\n",
" <td>前立腺癌の高リスク生化学的再発（BCR）患者を対象としたアンドロゲン遮断療法（ADT）を併用...</td>\n",
" <td>前立腺癌</td>\n",
" <td>前立腺癌</td>\n",
" <td>prostate cancer</td>\n",
" <td>BAY 1841788(darolutamide)とADTの24ヵ月間併用投与によって、プラ...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Histologically or cytologically confirmed ad...</td>\n",
" <td>- Pathological finding consistent with small c...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Male</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Drug: Darolutamide (BAY1841788, Nubeqa) Coated...</td>\n",
" <td>[Prostate Cancer]</td>\n",
" <td>[[0.020208006724715233, -0.7650324106216431, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>351</th>\n",
" <td>jRCT2031230279</td>\n",
" <td>NCT05862285</td>\n",
" <td>NaN</td>\n",
" <td>GENENTECH社及び／又はF.HOFFMANN-LA ROCHE LTDが依頼した試験に...</td>\n",
" <td>癌</td>\n",
" <td>癌</td>\n",
" <td>Cancer</td>\n",
" <td>本継続投与試験の目的は,親治験から移行する時点でまだ治験治療を受けており,その地域でその治療...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Eligible for continuing Roche IMP-based ther...</td>\n",
" <td>- Meet any of the study treatment discontinuat...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Ipatasertib: Ipatasertib will be administered ...</td>\n",
" <td>[Cancer]</td>\n",
" <td>[[-0.21449315547943115, -0.7045395374298096, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>385</th>\n",
" <td>jRCT2031230121</td>\n",
" <td>NCT04557449</td>\n",
" <td>NaN</td>\n",
" <td>進行固形がん患者を対象として，PF-07220060 の単剤投与および併用投与の安全性，忍容...</td>\n",
" <td>進行または転移性の乳癌，前立腺癌，およびその他の固形癌</td>\n",
" <td>進行または転移性の乳癌,前立腺癌,およびその他の固形癌</td>\n",
" <td>advanced or metastatic BC, prostate cancer or ...</td>\n",
" <td>パート1(用量漸増,食事の影響,DDIの評価パート) 1A: PF-07220060のMTD...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Disease * Part 1A/1D/1E: HR+HER2-BC, HR+HER2+B...</td>\n",
" <td>* Part 1D: participants who have had a gastrec...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>* Part 1A/1D/1E: PF-07220060 (CDK4 inhibitor) ...</td>\n",
" <td>[Advanced, Metastatic Bc, Prostate Cancer, Oth...</td>\n",
" <td>[[-0.4654146134853363, -0.4114530086517334, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>388</th>\n",
" <td>jRCT2031230109</td>\n",
" <td>NCT05514054</td>\n",
" <td>NaN</td>\n",
" <td>EMBER-4：2～5年間の術後内分泌療法による前治療歴を有する再発高リスクのER+、HER...</td>\n",
" <td>乳癌</td>\n",
" <td>乳癌</td>\n",
" <td>Breast Neoplasms</td>\n",
" <td>早期乳癌患者を対象としたimlunestrantと標準的な内分泌療法の比較試験</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>-Have a diagnosis of ER+, HER2- early-stage, r...</td>\n",
" <td>-Have any evidence of metastatic disease (incl...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>-Drug: Imlunestrant Administered orally. Other...</td>\n",
" <td>[Breast Neoplasms]</td>\n",
" <td>[[-0.3341570198535919, -0.6972700953483582, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>391</th>\n",
" <td>jRCT2031230090</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>MELK阻害剤OTS167POにおける転移性・進行性乳がん患者を対象とした安全性、忍容性およ...</td>\n",
" <td>再発・難治性の局所進行性・転移性乳がん及びトリプルネガティブ乳がん</td>\n",
" <td>再発・難治性の局所進行性・転移性乳がん及びトリプルネガティブ乳がん</td>\n",
" <td>Relapsed/Refractory Locally Advanced or Metast...</td>\n",
" <td>再発・難治性の局所進行性または転移性乳がん患者に対して、OTS167を経口カプセルで投与する...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Dose Escalation and Dose Expansion Cohorts 1. ...</td>\n",
" <td>Dose Escalation and Expansion Cohorts 1. Women...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Female</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>This is a Phase I dose escalation/expansion mu...</td>\n",
" <td>[Relapsed/Refract, Y Locally Advanced, Metasta...</td>\n",
" <td>[[-0.015294715762138367, -0.4993850290775299, ...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>392</th>\n",
" <td>jRCT2031230096</td>\n",
" <td>NCT05774951</td>\n",
" <td>NaN</td>\n",
" <td>根治的局所領域療法（化学療法の併用または非併用）および標準補助内分泌療法（ET）を少なくとも...</td>\n",
" <td>乳がん、早期乳がん</td>\n",
" <td>乳がん、早期乳がん</td>\n",
" <td>Breast Cancer, Early Breast Cancer</td>\n",
" <td>Treatment</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Women and Men, greater than or equal to 18 y...</td>\n",
" <td>- Inoperable locally advanced or metastatic br...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>arm A: continue with SoC ET as directed by inv...</td>\n",
" <td>[Breast Cancer, Early Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>402</th>\n",
" <td>jRCT2061230009</td>\n",
" <td>NCT05485766</td>\n",
" <td>NaN</td>\n",
" <td>gBRCA1/2遺伝子変異を有するトリプルネガティブ原発乳がんに対するプラチナ製剤、PARP...</td>\n",
" <td>トリプルネガティブ乳がん</td>\n",
" <td>トリプルネガティブ乳がん</td>\n",
" <td>Triple Negative Breast Neoplasms</td>\n",
" <td>術前療法としてgBRCA変異陽性手術可能または局所進行TNBCに対してペムブロリズマブ+パク...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1)Male/female subjects who are at least 18 yea...</td>\n",
" <td>1) Subjects who has a positive urine pregnancy...</td>\n",
" <td>18age old exceed</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>Triple Negative Breast Cancer, Breast Neoplasm...</td>\n",
" <td>Drug: Pembrolizumab 200 mg fixed dose, IV, eve...</td>\n",
" <td>[Triple Negative, Breast Neoplasms]</td>\n",
" <td>[[-0.21876227855682373, -0.4577382504940033, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>463</th>\n",
" <td>jRCT2061220087</td>\n",
" <td>NCT05629585</td>\n",
" <td>NaN</td>\n",
" <td>術前薬物療法後の外科的切除時に乳房及び／又は腋窩リンパ節に浸潤性残存病変を有するステージI～...</td>\n",
" <td>乳癌</td>\n",
" <td>乳癌</td>\n",
" <td>Breast Cancer</td>\n",
" <td>術前薬物療法後の外科的切除時に乳房および/または腋窩リンパ節に浸潤性残存病変を有するI~II...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Participant must be >= 18 years at the time of...</td>\n",
" <td>Stage IV (metastatic) TNBC. History of prior i...</td>\n",
" <td>18age old over</td>\n",
" <td>130age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Arm 1: Dato-DXd 6 mg/kg IV Q3W x 8 cycles + Du...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>515</th>\n",
" <td>jRCT2031220276</td>\n",
" <td>NCT05307705</td>\n",
" <td>NaN</td>\n",
" <td>PIK3CA H1047R変異を有する進行乳がん患者及びその他の固形がん患者を対象としたLO...</td>\n",
" <td>乳がん</td>\n",
" <td>乳がん</td>\n",
" <td>Breast Cancer</td>\n",
" <td>LOXO-783 の単独投与及び他の抗がん剤との併用投与における 第 2 相試験の推奨用量、...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>-Have advanced breast cancer or another solid ...</td>\n",
" <td>-Medical Conditions -Colorectal cancer -Endome...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>-Drug: LOXO-783 Oral Other Name: LY3849524 -Dr...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>555</th>\n",
" <td>jRCT2031220034</td>\n",
" <td>NCT04862663</td>\n",
" <td>NaN</td>\n",
" <td>局所進行（切除不能）又は転移性のホルモン受容体陽性／ヒト上皮細胞成長因子受容体2 陰性乳癌を...</td>\n",
" <td>局所進行（切除不能）又は転移性乳癌</td>\n",
" <td>局所進行(切除不能)又は転移性乳癌</td>\n",
" <td>Locally Advanced (Inoperable) or Metastatic Br...</td>\n",
" <td>Treatment</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Key inclusion criteria for both phases: 1. Adu...</td>\n",
" <td>Key exclusion criteria for both phases: 1. His...</td>\n",
" <td>18age old over</td>\n",
" <td>99age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Capivasertib: PO BD 4 days on /3 days off per ...</td>\n",
" <td>[Locally Advanced (Inoperable), Metastatic Bre...</td>\n",
" <td>[[-0.15552400052547455, -0.8326742053031921, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>590</th>\n",
" <td>jRCT2031210585</td>\n",
" <td>NCT05123482</td>\n",
" <td>NaN</td>\n",
" <td>進行又は転移性固形がん患者を対象としたAZD8205の単独療法及び他の抗がん剤との併用療法に...</td>\n",
" <td>乳癌、胆道癌、卵巣癌、子宮内膜癌</td>\n",
" <td>乳癌、胆道癌、卵巣癌、子宮内膜癌</td>\n",
" <td>Breast Cancer, Biliary Tract Carcinoma, Ovaria...</td>\n",
" <td>進行又は転移性固形がんに対する治療法候補としての新規化合物AZD8205の研究</td>\n",
" <td>1-2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Age18 years or more - Relapsed/metastatic so...</td>\n",
" <td>- Treatment with any of the following: 1. Nitr...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Sub-study1 AZD8205 Monotherapy AZD8205 is an a...</td>\n",
" <td>[Breast Cancer, Biliary Tract Carcinoma, Ovari...</td>\n",
" <td>[[-0.09860852360725403, -0.6294932961463928, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>593</th>\n",
" <td>jRCT2031210560</td>\n",
" <td>NCT05061823</td>\n",
" <td>NaN</td>\n",
" <td>複数のBintrafusp alfa（M7824）臨床試験の被験者を対象に長期データを収集す...</td>\n",
" <td>固形癌</td>\n",
" <td>固形癌</td>\n",
" <td>Cancer</td>\n",
" <td>本治験は、実施中のbintrafusp alfaの親試験( (NCT02517398, NC...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Participants who are currently enrolled in a...</td>\n",
" <td>- Participants who are pregnant or currently i...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Participants who are continuing treatment with...</td>\n",
" <td>[Cancer]</td>\n",
" <td>[[-0.21449315547943115, -0.7045395374298096, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>600</th>\n",
" <td>jRCT2041210123</td>\n",
" <td>NCT05114746</td>\n",
" <td>NaN</td>\n",
" <td>進行性PSMA陽性転移性去勢抵抗性前立腺がん（mCRPC）を有する患者を対象に177Lu-P...</td>\n",
" <td>前立腺癌</td>\n",
" <td>前立腺癌</td>\n",
" <td>Prostate Cancer</td>\n",
" <td>本治験の目的は、進行性PSMA陽性mCRPCの日本人患者に177Lu-PSMA-617を投与...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- ECOG performance status: 1. Post-taxane popu...</td>\n",
" <td>- Previous treatment with any of the following...</td>\n",
" <td>20age old over</td>\n",
" <td>No limit</td>\n",
" <td>Male</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Radiation: 177Lu-PSMA-617 administered intrave...</td>\n",
" <td>[Prostate Cancer]</td>\n",
" <td>[[0.020208006724715233, -0.7650324106216431, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>629</th>\n",
" <td>jRCT2052210099</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>乳がんを有する成人女性及び健康成人女性を対象とした乳房用マイクロ波画像診断装置IGS-000...</td>\n",
" <td>乳がん</td>\n",
" <td>乳がん</td>\n",
" <td>Breast cancer</td>\n",
" <td>本治験の目的は,乳がん又はその疑いのある者,並びに乳がん又はその疑いがない者を対象に乳房画像...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Breast cancer (including suspected) (1) One of...</td>\n",
" <td>(1) There is trauma with bleeding on the breas...</td>\n",
" <td>20age old over</td>\n",
" <td>No limit</td>\n",
" <td>Female</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>The test using IGS-0001 will be performed twic...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>691</th>\n",
" <td>jRCT2031200384</td>\n",
" <td>NCT04221542</td>\n",
" <td>NaN</td>\n",
" <td>転移性去勢抵抗性前立腺がん患者を対象としたAMG 509の安全性、忍容性、薬物動態及び有効性...</td>\n",
" <td>前立腺がん</td>\n",
" <td>前立腺がん</td>\n",
" <td>Prostate Cancer</td>\n",
" <td>成人被験者のAMG 509の安全性及び忍容性を評価し、最大耐量(MTD)又は第II 相推奨用...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Parts 1, 2, and 5: Participants with histolo...</td>\n",
" <td>- Pathological finding consistent with pure sm...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Male</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>- Experimental: Part 1: AMG 509 Intravenous (I...</td>\n",
" <td>[Prostate Cancer]</td>\n",
" <td>[[0.020208006724715233, -0.7650324106216431, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>698</th>\n",
" <td>jRCT2071200086</td>\n",
" <td>NCT04640623</td>\n",
" <td>NaN</td>\n",
" <td>膀胱全摘除術に不適格である，又は膀胱全摘除術を選択しなかった，カルメット・ゲラン桿菌（BCG...</td>\n",
" <td>膀胱癌</td>\n",
" <td>膀胱癌</td>\n",
" <td>Bladder Cancer</td>\n",
" <td>試験の目的は、高グレードTa又はT1乳頭状癌の併発の有無を問わない上皮内癌(CIS)患者にT...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Histologically confirmed diagnosis of persis...</td>\n",
" <td>- Histologically confirmed, muscle-invasive, l...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>TAR-200 Cohort 1: TAR-200 and Cetrelimab: TAR-...</td>\n",
" <td>[Bladder Cancer]</td>\n",
" <td>[[-0.206207275390625, -0.5713697671890259, -0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>729</th>\n",
" <td>jRCT2031200057</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>治療抵抗性乳がんを対象としたTDM-812の腫瘍内投与法の安全性評価を目的とした第I相試験</td>\n",
" <td>乳がん</td>\n",
" <td>乳がん</td>\n",
" <td>Breast cancer</td>\n",
" <td>TDM-812の腫瘍内投与の安全性および忍容性を評価し、今後の臨床評価に用いる腫瘍内投与にお...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td><Disease Characteristics> 1)Patients with inop...</td>\n",
" <td>1)Patients correspond to either of the followi...</td>\n",
" <td>20age old over</td>\n",
" <td>No limit</td>\n",
" <td>Female</td>\n",
" <td>NaN</td>\n",
" <td>Breast cancer</td>\n",
" <td>For the target tumor, the dose settled at each...</td>\n",
" <td>[Breast Cancer]</td>\n",
" <td>[[-0.09860841184854507, -0.629493236541748, -0...</td>\n",
" </tr>\n",
" </tbody>\n",
"</table>\n",
"<p>27 rows × 41 columns</p>\n",
"</div>"
],
"text/plain": [
" JRCT ID NCT No JapicCTI No \\\n",
"31 jRCT2061240081 NCT06393374 NaN \n",
"32 jRCT2031240476 NCT06312176 NaN \n",
"157 jRCT2052240059 NaN NaN \n",
"170 jRCT2031240096 NCT06380751 NaN \n",
"209 jRCT2031230750 NCT06188559 NaN \n",
"215 jRCT2031230723 NCT06112379 NaN \n",
"224 jRCT2051230196 NCT06105632 NaN \n",
"234 jRCT2031230677 NCT06206837 NaN \n",
"240 jRCT2061230102 NCT06103864 NaN \n",
"307 jRCT2061230074 NCT05952557 NaN \n",
"342 jRCT2051230094 NCT05794906 NaN \n",
"351 jRCT2031230279 NCT05862285 NaN \n",
"385 jRCT2031230121 NCT04557449 NaN \n",
"388 jRCT2031230109 NCT05514054 NaN \n",
"391 jRCT2031230090 NaN NaN \n",
"392 jRCT2031230096 NCT05774951 NaN \n",
"402 jRCT2061230009 NCT05485766 NaN \n",
"463 jRCT2061220087 NCT05629585 NaN \n",
"515 jRCT2031220276 NCT05307705 NaN \n",
"555 jRCT2031220034 NCT04862663 NaN \n",
"590 jRCT2031210585 NCT05123482 NaN \n",
"593 jRCT2031210560 NCT05061823 NaN \n",
"600 jRCT2041210123 NCT05114746 NaN \n",
"629 jRCT2052210099 NaN NaN \n",
"691 jRCT2031200384 NCT04221542 NaN \n",
"698 jRCT2071200086 NCT04640623 NaN \n",
"729 jRCT2031200057 NaN NaN \n",
"\n",
" Title \\\n",
"31 術前薬物療法後の手術時に病理学的完全奏効を達成していないトリプルネガティブ乳癌患者を対象に、... \n",
"32 ホルモン受容体陽性・ヒト上皮成長因子受容体2陰性（HR+/HER2-）の切除不能な局所進行又... \n",
"157 遺伝子HSD17B4高メチル化を有するHER2陽性ER陰性乳癌における非手術療法の有用性を評... \n",
"170 本治験の主要目的は、BRCA1、BRCA2 又は PALB2 変異を有し、HR 陽性、HER... \n",
"209 治療歴のある HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌の被験者を対象に，... \n",
"215 未治療のトリプルネガティブ又はホルモン受容体低発現／HER2陰性乳癌の成人患者を対象として、... \n",
"224 CDK4/6 阻害薬による前治療で進行したホルモン受容体陽性HER2 陰性の進行または転移乳... \n",
"234 18歳以上のER陽性／HER2陰性の進行または転移乳癌患者を対象として，経口タンパク質分解誘... \n",
"240 Programmed death-ligand（PD-L1）陽性の局所再発手術不能又は転移性... \n",
"307 根治的局所治療（化学療法の併用または非併用）を受けて疾患の兆候のない、再発リスクが中間～高リ... \n",
"342 前立腺癌の高リスク生化学的再発（BCR）患者を対象としたアンドロゲン遮断療法（ADT）を併用... \n",
"351 GENENTECH社及び／又はF.HOFFMANN-LA ROCHE LTDが依頼した試験に... \n",
"385 進行固形がん患者を対象として，PF-07220060 の単剤投与および併用投与の安全性，忍容... \n",
"388 EMBER-4：2～5年間の術後内分泌療法による前治療歴を有する再発高リスクのER+、HER... \n",
"391 MELK阻害剤OTS167POにおける転移性・進行性乳がん患者を対象とした安全性、忍容性およ... \n",
"392 根治的局所領域療法（化学療法の併用または非併用）および標準補助内分泌療法（ET）を少なくとも... \n",
"402 gBRCA1/2遺伝子変異を有するトリプルネガティブ原発乳がんに対するプラチナ製剤、PARP... \n",
"463 術前薬物療法後の外科的切除時に乳房及び／又は腋窩リンパ節に浸潤性残存病変を有するステージI～... \n",
"515 PIK3CA H1047R変異を有する進行乳がん患者及びその他の固形がん患者を対象としたLO... \n",
"555 局所進行（切除不能）又は転移性のホルモン受容体陽性／ヒト上皮細胞成長因子受容体2 陰性乳癌を... \n",
"590 進行又は転移性固形がん患者を対象としたAZD8205の単独療法及び他の抗がん剤との併用療法に... \n",
"593 複数のBintrafusp alfa（M7824）臨床試験の被験者を対象に長期データを収集す... \n",
"600 進行性PSMA陽性転移性去勢抵抗性前立腺がん（mCRPC）を有する患者を対象に177Lu-P... \n",
"629 乳がんを有する成人女性及び健康成人女性を対象とした乳房用マイクロ波画像診断装置IGS-000... \n",
"691 転移性去勢抵抗性前立腺がん患者を対象としたAMG 509の安全性、忍容性、薬物動態及び有効性... \n",
"698 膀胱全摘除術に不適格である，又は膀胱全摘除術を選択しなかった，カルメット・ゲラン桿菌（BCG... \n",
"729 治療抵抗性乳がんを対象としたTDM-812の腫瘍内投与法の安全性評価を目的とした第I相試験 \n",
"\n",
" TargetJ \\\n",
"31 トリプルネガティブ乳癌 \n",
"32 HR+/HER2-の切除不能局所進行又は転移性乳癌の患者 \n",
"157 乳がん \n",
"170 進行乳癌 \n",
"209 HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌 \n",
"215 乳癌 \n",
"224 ホルモン受容体（HR）陽性ヒト上皮増殖因子受容体2（HER2）陰性の進行または転移乳癌 \n",
"234 エストロゲン受容体陽性／ヒト上皮増殖因子受容体 2 陰性の進行または転移乳癌 \n",
"240 乳癌 \n",
"307 乳がん、早期乳がん \n",
"342 前立腺癌 \n",
"351 癌 \n",
"385 進行または転移性の乳癌，前立腺癌，およびその他の固形癌 \n",
"388 乳癌 \n",
"391 再発・難治性の局所進行性・転移性乳がん及びトリプルネガティブ乳がん \n",
"392 乳がん、早期乳がん \n",
"402 トリプルネガティブ乳がん \n",
"463 乳癌 \n",
"515 乳がん \n",
"555 局所進行（切除不能）又は転移性乳癌 \n",
"590 乳癌、胆道癌、卵巣癌、子宮内膜癌 \n",
"593 固形癌 \n",
"600 前立腺癌 \n",
"629 乳がん \n",
"691 前立腺がん \n",
"698 膀胱癌 \n",
"729 乳がん \n",
"\n",
" Target \\\n",
"31 トリプルネガティブ乳癌 \n",
"32 HR+/HER2-の切除不能局所進行又は転移性乳癌の患者 \n",
"157 乳がん \n",
"170 進行乳癌 \n",
"209 HER2 陽性又は HER2 低発現の切除不能又は転移性乳癌 \n",
"215 乳癌 \n",
"224 ホルモン受容体(HR)陽性ヒト上皮増殖因子受容体2(HER2)陰性の進行または転移乳癌 \n",
"234 エストロゲン受容体陽性/ヒト上皮増殖因子受容体 2 陰性の進行または転移乳癌 \n",
"240 乳癌 \n",
"307 乳がん、早期乳がん \n",
"342 前立腺癌 \n",
"351 癌 \n",
"385 進行または転移性の乳癌,前立腺癌,およびその他の固形癌 \n",
"388 乳癌 \n",
"391 再発・難治性の局所進行性・転移性乳がん及びトリプルネガティブ乳がん \n",
"392 乳がん、早期乳がん \n",
"402 トリプルネガティブ乳がん \n",
"463 乳癌 \n",
"515 乳がん \n",
"555 局所進行(切除不能)又は転移性乳癌 \n",
"590 乳癌、胆道癌、卵巣癌、子宮内膜癌 \n",
"593 固形癌 \n",
"600 前立腺癌 \n",
"629 乳がん \n",
"691 前立腺がん \n",
"698 膀胱癌 \n",
"729 乳がん \n",
"\n",
" TargetEnglish \\\n",
"31 Triple negative breast cancer \n",
"32 HR+/HER2 unresectable locally advanced or meta... \n",
"157 Breast cancer \n",
"170 Advanced Breast Cancer \n",
"209 HER2-positive or HER2-low unresectable or meta... \n",
"215 Breast Cancer \n",
"224 HR-positive, HER2-negative Advanced or Metasta... \n",
"234 ER+/HER2- advanced or metastatic breast cancer \n",
"240 Breast Cancer \n",
"307 Breast Cancer, Early Breast Cancer \n",
"342 prostate cancer \n",
"351 Cancer \n",
"385 advanced or metastatic BC, prostate cancer or ... \n",
"388 Breast Neoplasms \n",
"391 Relapsed/Refractory Locally Advanced or Metast... \n",
"392 Breast Cancer, Early Breast Cancer \n",
"402 Triple Negative Breast Neoplasms \n",
"463 Breast Cancer \n",
"515 Breast Cancer \n",
"555 Locally Advanced (Inoperable) or Metastatic Br... \n",
"590 Breast Cancer, Biliary Tract Carcinoma, Ovaria... \n",
"593 Cancer \n",
"600 Prostate Cancer \n",
"629 Breast cancer \n",
"691 Prostate Cancer \n",
"698 Bladder Cancer \n",
"729 Breast cancer \n",
"\n",
" 研究・治験の目的 試験等のフェーズ 試験の種類 ... \\\n",
"31 術前薬物療法後の手術時に病理学的完全奏効を達成していないトリプルネガティブ乳癌患者を対象に、... 3 NaN ... \n",
"32 HR+/HER2-の切除不能な局所進行又は転移性乳癌患者を対象にMK-2870の単剤及びペム... 3 NaN ... \n",
"157 HSD17B4高メチル化(HSD17B4 hypermethylation:HH)を有するH... 2 NaN ... \n",
"170 Treatment 3 NaN ... \n",
"209 治療 2 NaN ... \n",
"215 未治療のトリプルネガティブ又はホルモン受容体低発現/HER2陰性乳癌の成人患者を対象として、... 3 NaN ... \n",
"224 CDK4/6阻害薬による前治療で進行したHR陽性HER2陰性の進行または転移乳癌患者を対象に... 3 NaN ... \n",
"234 進行乳癌患者を対象として,vepdegestrantとPF-07220060を併用投与したと... 1-2 NaN ... \n",
"240 PD-L1陽性の局所再発手術不能または転移性TNBC患者を対象に、デュルバルマブ併用または非... 3 NaN ... \n",
"307 Treatment 3 NaN ... \n",
"342 BAY 1841788(darolutamide)とADTの24ヵ月間併用投与によって、プラ... 3 NaN ... \n",
"351 本継続投与試験の目的は,親治験から移行する時点でまだ治験治療を受けており,その地域でその治療... 3 NaN ... \n",
"385 パート1(用量漸増,食事の影響,DDIの評価パート) 1A: PF-07220060のMTD... 1 NaN ... \n",
"388 早期乳癌患者を対象としたimlunestrantと標準的な内分泌療法の比較試験 3 NaN ... \n",
"391 再発・難治性の局所進行性または転移性乳がん患者に対して、OTS167を経口カプセルで投与する... 1 NaN ... \n",
"392 Treatment 3 NaN ... \n",
"402 術前療法としてgBRCA変異陽性手術可能または局所進行TNBCに対してペムブロリズマブ+パク... 2 NaN ... \n",
"463 術前薬物療法後の外科的切除時に乳房および/または腋窩リンパ節に浸潤性残存病変を有するI~II... 3 NaN ... \n",
"515 LOXO-783 の単独投与及び他の抗がん剤との併用投与における 第 2 相試験の推奨用量、... 1 NaN ... \n",
"555 Treatment 3 NaN ... \n",
"590 進行又は転移性固形がんに対する治療法候補としての新規化合物AZD8205の研究 1-2 NaN ... \n",
"593 本治験は、実施中のbintrafusp alfaの親試験( (NCT02517398, NC... 3 NaN ... \n",
"600 本治験の目的は、進行性PSMA陽性mCRPCの日本人患者に177Lu-PSMA-617を投与... 2 NaN ... \n",
"629 本治験の目的は,乳がん又はその疑いのある者,並びに乳がん又はその疑いがない者を対象に乳房画像... 2 NaN ... \n",
"691 成人被験者のAMG 509の安全性及び忍容性を評価し、最大耐量(MTD)又は第II 相推奨用... 1 NaN ... \n",
"698 試験の目的は、高グレードTa又はT1乳頭状癌の併発の有無を問わない上皮内癌(CIS)患者にT... 2 NaN ... \n",
"729 TDM-812の腫瘍内投与の安全性および忍容性を評価し、今後の臨床評価に用いる腫瘍内投与にお... 1 NaN ... \n",
"\n",
" Inclusion Criteria \\\n",
"31 -Has centrally confirmed TNBC, as defined by t... \n",
"32 -Has unresectable locally advanced or metastat... \n",
"157 1. Histologically confirmed invasive breast ca... \n",
"170 - Adult females, pre/peri-menopausal and/or po... \n",
"209 (1) Male or female, aged >=18 years at the tim... \n",
"215 1. Participant must be >= 18 years at the time... \n",
"224 * Histological confirmation of breast cancer w... \n",
"234 Inclusion Criteria: * Histological or cytologi... \n",
"240 Histologically or cytologically documented loc... \n",
"307 - Women and Men; 18 years or more at the time ... \n",
"342 - Histologically or cytologically confirmed ad... \n",
"351 - Eligible for continuing Roche IMP-based ther... \n",
"385 Disease * Part 1A/1D/1E: HR+HER2-BC, HR+HER2+B... \n",
"388 -Have a diagnosis of ER+, HER2- early-stage, r... \n",
"391 Dose Escalation and Dose Expansion Cohorts 1. ... \n",
"392 - Women and Men, greater than or equal to 18 y... \n",
"402 1)Male/female subjects who are at least 18 yea... \n",
"463 Participant must be >= 18 years at the time of... \n",
"515 -Have advanced breast cancer or another solid ... \n",
"555 Key inclusion criteria for both phases: 1. Adu... \n",
"590 - Age18 years or more - Relapsed/metastatic so... \n",
"593 - Participants who are currently enrolled in a... \n",
"600 - ECOG performance status: 1. Post-taxane popu... \n",
"629 Breast cancer (including suspected) (1) One of... \n",
"691 - Parts 1, 2, and 5: Participants with histolo... \n",
"698 - Histologically confirmed diagnosis of persis... \n",
"729 <Disease Characteristics> 1)Patients with inop... \n",
"\n",
" Exclusion Criteria Age Minimum \\\n",
"31 -Has a known germline breast cancer gene (BRCA... 18age old over \n",
"32 -Has breast cancer amenable to treatment with ... 18age old over \n",
"157 1. History of other malignancy within the last... 20age old over \n",
"170 - Participants with history of MDS/AML or with... 18age old over \n",
"209 (1) Presence of brain or subdural metastases, ... 18age old over \n",
"215 1. As judged by the investigator, any evidence... 18age old over \n",
"224 * Any medical or psychiatric condition that ma... 18age old over \n",
"234 Exclusion Criteria: * visceral crisis at risk ... 18age old over \n",
"240 As judged by investigator, severe or uncontrol... 18age old over \n",
"307 - Inoperable locally advanced or metastatic br... 18age old over \n",
"342 - Pathological finding consistent with small c... 18age old over \n",
"351 - Meet any of the study treatment discontinuat... 18age old over \n",
"385 * Part 1D: participants who have had a gastrec... 18age old over \n",
"388 -Have any evidence of metastatic disease (incl... 18age old over \n",
"391 Dose Escalation and Expansion Cohorts 1. Women... 18age old over \n",
"392 - Inoperable locally advanced or metastatic br... 18age old over \n",
"402 1) Subjects who has a positive urine pregnancy... 18age old exceed \n",
"463 Stage IV (metastatic) TNBC. History of prior i... 18age old over \n",
"515 -Medical Conditions -Colorectal cancer -Endome... 18age old over \n",
"555 Key exclusion criteria for both phases: 1. His... 18age old over \n",
"590 - Treatment with any of the following: 1. Nitr... 18age old over \n",
"593 - Participants who are pregnant or currently i... 18age old over \n",
"600 - Previous treatment with any of the following... 20age old over \n",
"629 (1) There is trauma with bleeding on the breas... 20age old over \n",
"691 - Pathological finding consistent with pure sm... 18age old over \n",
"698 - Histologically confirmed, muscle-invasive, l... 18age old over \n",
"729 1)Patients correspond to either of the followi... 20age old over \n",
"\n",
" Age Maximum Gender Discontinuation Criteria \\\n",
"31 No limit Both NaN \n",
"32 No limit Both NaN \n",
"157 No limit Female NaN \n",
"170 No limit Both NaN \n",
"209 No limit Both NaN \n",
"215 No limit Both NaN \n",
"224 No limit Both NaN \n",
"234 No limit Both NaN \n",
"240 No limit Both NaN \n",
"307 No limit NaN NaN \n",
"342 No limit Male NaN \n",
"351 No limit Both NaN \n",
"385 No limit Both NaN \n",
"388 No limit Both NaN \n",
"391 No limit Female NaN \n",
"392 No limit Both NaN \n",
"402 No limit Both NaN \n",
"463 130age old under Both NaN \n",
"515 No limit Both NaN \n",
"555 99age old under Both NaN \n",
"590 No limit Both NaN \n",
"593 No limit Both NaN \n",
"600 No limit Male NaN \n",
"629 No limit Female NaN \n",
"691 No limit Male NaN \n",
"698 No limit Both NaN \n",
"729 No limit Female NaN \n",
"\n",
" Keyword \\\n",
"31 NaN \n",
"32 NaN \n",
"157 NaN \n",
"170 NaN \n",
"209 NaN \n",
"215 NaN \n",
"224 NaN \n",
"234 NaN \n",
"240 NaN \n",
"307 NaN \n",
"342 NaN \n",
"351 NaN \n",
"385 NaN \n",
"388 NaN \n",
"391 NaN \n",
"392 NaN \n",
"402 Triple Negative Breast Cancer, Breast Neoplasm... \n",
"463 NaN \n",
"515 NaN \n",
"555 NaN \n",
"590 NaN \n",
"593 NaN \n",
"600 NaN \n",
"629 NaN \n",
"691 NaN \n",
"698 NaN \n",
"729 Breast cancer \n",
"\n",
" Intervention(s) \\\n",
"31 -Arm 1: MK-2870 4mg/kg intravenous (IV) every ... \n",
"32 Arm A:MK-2870 Participants receive 4 mg/kg of ... \n",
"157 Omitting breast surgery after preoperative che... \n",
"170 Experimental: Arm 1: saruparib (AZD5305) plus ... \n",
"209 Generic Name:NA Study Treatment in dose optimi... \n",
"215 - Experimental arm: Dato-DXd plus durvalumab n... \n",
"224 Arm A (Experimental Arm) PF-07220060 plus Fulv... \n",
"234 Drug: vepdegestrant Daily oral dosages of vepd... \n",
"240 Arm 1: Dato-DXd + durvalumab Arm 2: Investigat... \n",
"307 arm A: continue with SoC ET as directed by inv... \n",
"342 Drug: Darolutamide (BAY1841788, Nubeqa) Coated... \n",
"351 Ipatasertib: Ipatasertib will be administered ... \n",
"385 * Part 1A/1D/1E: PF-07220060 (CDK4 inhibitor) ... \n",
"388 -Drug: Imlunestrant Administered orally. Other... \n",
"391 This is a Phase I dose escalation/expansion mu... \n",
"392 arm A: continue with SoC ET as directed by inv... \n",
"402 Drug: Pembrolizumab 200 mg fixed dose, IV, eve... \n",
"463 Arm 1: Dato-DXd 6 mg/kg IV Q3W x 8 cycles + Du... \n",
"515 -Drug: LOXO-783 Oral Other Name: LY3849524 -Dr... \n",
"555 Capivasertib: PO BD 4 days on /3 days off per ... \n",
"590 Sub-study1 AZD8205 Monotherapy AZD8205 is an a... \n",
"593 Participants who are continuing treatment with... \n",
"600 Radiation: 177Lu-PSMA-617 administered intrave... \n",
"629 The test using IGS-0001 will be performed twic... \n",
"691 - Experimental: Part 1: AMG 509 Intravenous (I... \n",
"698 TAR-200 Cohort 1: TAR-200 and Cetrelimab: TAR-... \n",
"729 For the target tumor, the dose settled at each... \n",
"\n",
" TargetWord \\\n",
"31 [Triple Negative, Breast Cancer] \n",
"32 [Hr+/Her2 Unresectable Locally Advanced, Metas... \n",
"157 [Breast Cancer] \n",
"170 [Advanced Breast Cancer] \n",
"209 [Her2-Positive, Her2-Low Unresectable, Metasta... \n",
"215 [Breast Cancer] \n",
"224 [Hr-Positive, Her2-Negative Advanced, Metastat... \n",
"234 [Er+/Her2- Advanced, Metastatic Breast Cancer] \n",
"240 [Breast Cancer] \n",
"307 [Breast Cancer, Early Breast Cancer] \n",
"342 [Prostate Cancer] \n",
"351 [Cancer] \n",
"385 [Advanced, Metastatic Bc, Prostate Cancer, Oth... \n",
"388 [Breast Neoplasms] \n",
"391 [Relapsed/Refract, Y Locally Advanced, Metasta... \n",
"392 [Breast Cancer, Early Breast Cancer] \n",
"402 [Triple Negative, Breast Neoplasms] \n",
"463 [Breast Cancer] \n",
"515 [Breast Cancer] \n",
"555 [Locally Advanced (Inoperable), Metastatic Bre... \n",
"590 [Breast Cancer, Biliary Tract Carcinoma, Ovari... \n",
"593 [Cancer] \n",
"600 [Prostate Cancer] \n",
"629 [Breast Cancer] \n",
"691 [Prostate Cancer] \n",
"698 [Bladder Cancer] \n",
"729 [Breast Cancer] \n",
"\n",
" TargetVec \n",
"31 [[-0.21876227855682373, -0.4577382504940033, -... \n",
"32 [[0.04888693988323212, -0.7584289908409119, -0... \n",
"157 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"170 [[-0.21163925528526306, -0.5019860863685608, -... \n",
"209 [[-0.08892004191875458, -0.8978654146194458, -... \n",
"215 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"224 [[-0.083187997341156, -0.7571865916252136, -0.... \n",
"234 [[-0.154923215508461, -0.39443543553352356, -0... \n",
"240 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"307 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"342 [[0.020208006724715233, -0.7650324106216431, -... \n",
"351 [[-0.21449315547943115, -0.7045395374298096, -... \n",
"385 [[-0.4654146134853363, -0.4114530086517334, -0... \n",
"388 [[-0.3341570198535919, -0.6972700953483582, -0... \n",
"391 [[-0.015294715762138367, -0.4993850290775299, ... \n",
"392 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"402 [[-0.21876227855682373, -0.4577382504940033, -... \n",
"463 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"515 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"555 [[-0.15552400052547455, -0.8326742053031921, -... \n",
"590 [[-0.09860852360725403, -0.6294932961463928, -... \n",
"593 [[-0.21449315547943115, -0.7045395374298096, -... \n",
"600 [[0.020208006724715233, -0.7650324106216431, -... \n",
"629 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"691 [[0.020208006724715233, -0.7650324106216431, -... \n",
"698 [[-0.206207275390625, -0.5713697671890259, -0.... \n",
"729 [[-0.09860841184854507, -0.629493236541748, -0... \n",
"\n",
"[27 rows x 41 columns]"
]
},
"execution_count": 18,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"get_matched_df(processed_df, \"breast cancer\", model, threshold=0.925)"
]
},
{
"cell_type": "code",
"execution_count": 19,
"metadata": {},
"outputs": [
{
"data": {
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" <th></th>\n",
" <th>JRCT ID</th>\n",
" <th>NCT No</th>\n",
" <th>JapicCTI No</th>\n",
" <th>Title</th>\n",
" <th>TargetJ</th>\n",
" <th>Target</th>\n",
" <th>TargetEnglish</th>\n",
" <th>研究・治験の目的</th>\n",
" <th>試験等のフェーズ</th>\n",
" <th>試験の種類</th>\n",
" <th>...</th>\n",
" <th>Inclusion Criteria</th>\n",
" <th>Exclusion Criteria</th>\n",
" <th>Age Minimum</th>\n",
" <th>Age Maximum</th>\n",
" <th>Gender</th>\n",
" <th>Discontinuation Criteria</th>\n",
" <th>Keyword</th>\n",
" <th>Intervention(s)</th>\n",
" <th>TargetWord</th>\n",
" <th>TargetVec</th>\n",
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" <tbody>\n",
" <tr>\n",
" <th>82</th>\n",
" <td>jRCT2051240121</td>\n",
" <td>NCT06413706</td>\n",
" <td>NaN</td>\n",
" <td>放射線療法後の悪性神経膠腫の小児および若年成人を対象に、アベマシクリブ＋テモゾロミドとテモゾ...</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>High-Grade Glioma</td>\n",
" <td>放射線療法後の悪性神経膠腫を有する小児および若年成人を対象に、アベマシクリブとテモゾロミドの...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Subjects required to meet all the folloiwng cr...</td>\n",
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" <td>No limit</td>\n",
" <td>21age old not</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Drug: Abemaciclib Administered orally Other Na...</td>\n",
" <td>[High-Grade Glioma]</td>\n",
" <td>[[-0.12244764715433121, -0.5778073668479919, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>87</th>\n",
" <td>jRCT2051240119</td>\n",
" <td>NCT03423628</td>\n",
" <td>NaN</td>\n",
" <td>多形性膠芽腫患者及び固形がんの脳転移患者を対象に、放射線療法併用下でAZD1390を漸増投与...</td>\n",
" <td>再発多形性膠芽腫</td>\n",
" <td>再発多形性膠芽腫</td>\n",
" <td>Recurrent Glioblastoma Multiforme</td>\n",
" <td>Treatment</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Provision of formalin-fixed paraffin embedde...</td>\n",
" <td>- Administration of chemotherapy or any invest...</td>\n",
" <td>18age old over</td>\n",
" <td>130age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>AZD1390 + Radiation Therapy Drug: AZD1390 - AZ...</td>\n",
" <td>[Recurrent, Glioblastoma Multif, Me]</td>\n",
" <td>[[-0.2750183045864105, -0.5264511704444885, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>175</th>\n",
" <td>jRCT2031240090</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発悪性神経膠腫に対する治療用放射性薬剤64Cu-ATSMの有効性を検証するランダム化比較医...</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>Malignant glioma</td>\n",
" <td>再発・難治性悪性神経膠腫を対象として、64Cu-diacetyl-bis(N4-methyl...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1) Histologically diagnosed as high grade glio...</td>\n",
" <td>1) Have a history or merger of other malignanc...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>glioblastoma, grade3/4 astrocytoma, grade3 oli...</td>\n",
" <td>Group A: BPC Therapy Depending on the patient'...</td>\n",
" <td>[Malignant Glioma]</td>\n",
" <td>[[-0.33767956495285034, -0.4648125171661377, -...</td>\n",
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" <tr>\n",
" <th>263</th>\n",
" <td>jRCT2041230136</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発膠芽腫に対するTUG1を標的とした核酸医薬医師主導第I相試験</td>\n",
" <td>再発膠芽腫</td>\n",
" <td>再発膠芽腫</td>\n",
" <td>recurrent glioblastoma</td>\n",
" <td>再発膠芽腫患者を対象としてTUG1ASOを投与した場合の投与時の安全性を検討し、至適投与量を...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>(1) Patients with a histological diagnosis of ...</td>\n",
" <td>(1) Patients with extracerebral metastases. (2...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Dosing frequency: 1 time /week Dose Levels Lev...</td>\n",
" <td>[Recurrent, Glioblastoma]</td>\n",
" <td>[[-0.27501848340034485, -0.5264514088630676, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>361</th>\n",
" <td>jRCT2051230069</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>神経膠腫患者に対するロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全...</td>\n",
" <td>神経膠腫</td>\n",
" <td>神経膠腫</td>\n",
" <td>Glioma</td>\n",
" <td>神経膠腫患者におけるロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併用療法の安全...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td><Cohort 1> All of the following items shall be...</td>\n",
" <td><Common to Cohort 1 and Cohort 2> 1) Active mu...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td><cohort1> Lomustine 130 mg/m2 orally every 6 w...</td>\n",
" <td>[Glioma]</td>\n",
" <td>[[-0.21631155908107758, -0.5687925219535828, -...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>401</th>\n",
" <td>jRCT2032230060</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>初発IDH野生型低悪性度神経膠腫に対する交流電場腫瘍治療システムの有効性と安全性を検証する多...</td>\n",
" <td>IDH野生型神経膠腫（グレードⅢ）（退形成性星細胞腫）</td>\n",
" <td>IDH野生型神経膠腫(グレードIII)(退形成性星細胞腫)</td>\n",
" <td>IDH wild-type glioma (grade III) (anaplastic a...</td>\n",
" <td>初発IDH野生型低悪性度神経膠腫を対象に、放射線化学療法後のテモゾロミド維持療法期における交...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>At the time of enrollment, patients will be in...</td>\n",
" <td>Any of the following conditions shall not appl...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>Glioma</td>\n",
" <td>The patient using the product should shave all...</td>\n",
" <td>[Idh Wild-Type Glioma (Grade Iii) (Anaplastic ...</td>\n",
" <td>[[-0.3403506577014923, -0.5657796859741211, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>414</th>\n",
" <td>jRCT2031230007</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>BRAF融合遺伝子陽性の進行・再発の低悪性度神経膠腫または膵癌に対するビニメチニブの第Ⅱ相医...</td>\n",
" <td>低悪性度神経膠腫、膵癌</td>\n",
" <td>低悪性度神経膠腫、膵癌</td>\n",
" <td>Low-grade glioma, pancreatic cancer</td>\n",
" <td>BRAF融合遺伝子または遺伝子再構成陽性の切除不能または再発の低悪性度神経膠腫(コホート A...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Inclusion criteria for both cohort A and B 1) ...</td>\n",
" <td>1) Active double primary cancer (but not (1)-(...</td>\n",
" <td>12age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>BRAF fusion gene, BRAF rearrangement, low-grad...</td>\n",
" <td>Binimetinib is administered 45 mg orally, twic...</td>\n",
" <td>[Low-Grade Glioma, Pancreatic Cancer]</td>\n",
" <td>[[-0.18604964017868042, -0.547483503818512, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>636</th>\n",
" <td>jRCT2031210299</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発悪性神経膠腫患者を対象としたDSP-0390の第1相試験</td>\n",
" <td>再発悪性神経膠腫</td>\n",
" <td>再発悪性神経膠腫</td>\n",
" <td>Recurrent High-Grade Glioma</td>\n",
" <td>再発悪性神経膠腫患者を対象にDSP-0390を経口投与したときの安全性、薬物動態、薬力学及び...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1. Estimated life expectancy >= 3 months 2. Re...</td>\n",
" <td>1. Prior therapy with bevacizumab or other ant...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Patients will receive DSP-0390 orally once dai...</td>\n",
" <td>[Recurrent, High-Grade Glioma]</td>\n",
" <td>[[-0.2750183045864105, -0.5264511704444885, -0...</td>\n",
" </tr>\n",
" <tr>\n",
" <th>712</th>\n",
" <td>jRCT2031200153</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Cellm-001による初発膠芽腫治療効果無作為比較対照試験</td>\n",
" <td>膠芽腫</td>\n",
" <td>膠芽腫</td>\n",
" <td>glioblastoma</td>\n",
" <td>脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>(1) 18 years old or older and 75 years old or ...</td>\n",
" <td>(1) Systemic administration of corticosteroids...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Inject the investigational drug (Cellm-001 or ...</td>\n",
" <td>[Glioblastoma]</td>\n",
" <td>[[-0.15113382041454315, -0.5002245306968689, -...</td>\n",
" </tr>\n",
" </tbody>\n",
"</table>\n",
"<p>9 rows × 41 columns</p>\n",
"</div>"
],
"text/plain": [
" JRCT ID NCT No JapicCTI No \\\n",
"82 jRCT2051240121 NCT06413706 NaN \n",
"87 jRCT2051240119 NCT03423628 NaN \n",
"175 jRCT2031240090 NaN NaN \n",
"263 jRCT2041230136 NaN NaN \n",
"361 jRCT2051230069 NaN NaN \n",
"401 jRCT2032230060 NaN NaN \n",
"414 jRCT2031230007 NaN NaN \n",
"636 jRCT2031210299 NaN NaN \n",
"712 jRCT2031200153 NaN NaN \n",
"\n",
" Title \\\n",
"82 放射線療法後の悪性神経膠腫の小児および若年成人を対象に、アベマシクリブ＋テモゾロミドとテモゾ... \n",
"87 多形性膠芽腫患者及び固形がんの脳転移患者を対象に、放射線療法併用下でAZD1390を漸増投与... \n",
"175 再発悪性神経膠腫に対する治療用放射性薬剤64Cu-ATSMの有効性を検証するランダム化比較医... \n",
"263 再発膠芽腫に対するTUG1を標的とした核酸医薬医師主導第I相試験 \n",
"361 神経膠腫患者に対するロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全... \n",
"401 初発IDH野生型低悪性度神経膠腫に対する交流電場腫瘍治療システムの有効性と安全性を検証する多... \n",
"414 BRAF融合遺伝子陽性の進行・再発の低悪性度神経膠腫または膵癌に対するビニメチニブの第Ⅱ相医... \n",
"636 再発悪性神経膠腫患者を対象としたDSP-0390の第1相試験 \n",
"712 Cellm-001による初発膠芽腫治療効果無作為比較対照試験 \n",
"\n",
" TargetJ Target \\\n",
"82 悪性神経膠腫 悪性神経膠腫 \n",
"87 再発多形性膠芽腫 再発多形性膠芽腫 \n",
"175 悪性神経膠腫 悪性神経膠腫 \n",
"263 再発膠芽腫 再発膠芽腫 \n",
"361 神経膠腫 神経膠腫 \n",
"401 IDH野生型神経膠腫（グレードⅢ）（退形成性星細胞腫） IDH野生型神経膠腫(グレードIII)(退形成性星細胞腫) \n",
"414 低悪性度神経膠腫、膵癌 低悪性度神経膠腫、膵癌 \n",
"636 再発悪性神経膠腫 再発悪性神経膠腫 \n",
"712 膠芽腫 膠芽腫 \n",
"\n",
" TargetEnglish \\\n",
"82 High-Grade Glioma \n",
"87 Recurrent Glioblastoma Multiforme \n",
"175 Malignant glioma \n",
"263 recurrent glioblastoma \n",
"361 Glioma \n",
"401 IDH wild-type glioma (grade III) (anaplastic a... \n",
"414 Low-grade glioma, pancreatic cancer \n",
"636 Recurrent High-Grade Glioma \n",
"712 glioblastoma \n",
"\n",
" 研究・治験の目的 試験等のフェーズ 試験の種類 ... \\\n",
"82 放射線療法後の悪性神経膠腫を有する小児および若年成人を対象に、アベマシクリブとテモゾロミドの... 2 NaN ... \n",
"87 Treatment 1 NaN ... \n",
"175 再発・難治性悪性神経膠腫を対象として、64Cu-diacetyl-bis(N4-methyl... 3 NaN ... \n",
"263 再発膠芽腫患者を対象としてTUG1ASOを投与した場合の投与時の安全性を検討し、至適投与量を... 1 NaN ... \n",
"361 神経膠腫患者におけるロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併用療法の安全... 1 NaN ... \n",
"401 初発IDH野生型低悪性度神経膠腫を対象に、放射線化学療法後のテモゾロミド維持療法期における交... 2 NaN ... \n",
"414 BRAF融合遺伝子または遺伝子再構成陽性の切除不能または再発の低悪性度神経膠腫(コホート A... 2 NaN ... \n",
"636 再発悪性神経膠腫患者を対象にDSP-0390を経口投与したときの安全性、薬物動態、薬力学及び... 1 NaN ... \n",
"712 脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術... 3 NaN ... \n",
"\n",
" Inclusion Criteria \\\n",
"82 Subjects required to meet all the folloiwng cr... \n",
"87 - Provision of formalin-fixed paraffin embedde... \n",
"175 1) Histologically diagnosed as high grade glio... \n",
"263 (1) Patients with a histological diagnosis of ... \n",
"361 <Cohort 1> All of the following items shall be... \n",
"401 At the time of enrollment, patients will be in... \n",
"414 Inclusion criteria for both cohort A and B 1) ... \n",
"636 1. Estimated life expectancy >= 3 months 2. Re... \n",
"712 (1) 18 years old or older and 75 years old or ... \n",
"\n",
" Exclusion Criteria Age Minimum \\\n",
"82 Patients who meets any of the following criter... No limit \n",
"87 - Administration of chemotherapy or any invest... 18age old over \n",
"175 1) Have a history or merger of other malignanc... 18age old over \n",
"263 (1) Patients with extracerebral metastases. (2... 18age old over \n",
"361 <Common to Cohort 1 and Cohort 2> 1) Active mu... 18age old over \n",
"401 Any of the following conditions shall not appl... 18age old over \n",
"414 1) Active double primary cancer (but not (1)-(... 12age old over \n",
"636 1. Prior therapy with bevacizumab or other ant... 18age old over \n",
"712 (1) Systemic administration of corticosteroids... 18age old over \n",
"\n",
" Age Maximum Gender Discontinuation Criteria \\\n",
"82 21age old not NaN NaN \n",
"87 130age old under Both NaN \n",
"175 75age old under Both NaN \n",
"263 75age old under Both NaN \n",
"361 No limit Both NaN \n",
"401 No limit Both NaN \n",
"414 No limit Both NaN \n",
"636 No limit Both NaN \n",
"712 75age old under Both NaN \n",
"\n",
" Keyword \\\n",
"82 NaN \n",
"87 NaN \n",
"175 glioblastoma, grade3/4 astrocytoma, grade3 oli... \n",
"263 NaN \n",
"361 NaN \n",
"401 Glioma \n",
"414 BRAF fusion gene, BRAF rearrangement, low-grad... \n",
"636 NaN \n",
"712 NaN \n",
"\n",
" Intervention(s) \\\n",
"82 Drug: Abemaciclib Administered orally Other Na... \n",
"87 AZD1390 + Radiation Therapy Drug: AZD1390 - AZ... \n",
"175 Group A: BPC Therapy Depending on the patient'... \n",
"263 Dosing frequency: 1 time /week Dose Levels Lev... \n",
"361 <cohort1> Lomustine 130 mg/m2 orally every 6 w... \n",
"401 The patient using the product should shave all... \n",
"414 Binimetinib is administered 45 mg orally, twic... \n",
"636 Patients will receive DSP-0390 orally once dai... \n",
"712 Inject the investigational drug (Cellm-001 or ... \n",
"\n",
" TargetWord \\\n",
"82 [High-Grade Glioma] \n",
"87 [Recurrent, Glioblastoma Multif, Me] \n",
"175 [Malignant Glioma] \n",
"263 [Recurrent, Glioblastoma] \n",
"361 [Glioma] \n",
"401 [Idh Wild-Type Glioma (Grade Iii) (Anaplastic ... \n",
"414 [Low-Grade Glioma, Pancreatic Cancer] \n",
"636 [Recurrent, High-Grade Glioma] \n",
"712 [Glioblastoma] \n",
"\n",
" TargetVec \n",
"82 [[-0.12244764715433121, -0.5778073668479919, -... \n",
"87 [[-0.2750183045864105, -0.5264511704444885, -0... \n",
"175 [[-0.33767956495285034, -0.4648125171661377, -... \n",
"263 [[-0.27501848340034485, -0.5264514088630676, -... \n",
"361 [[-0.21631155908107758, -0.5687925219535828, -... \n",
"401 [[-0.3403506577014923, -0.5657796859741211, -0... \n",
"414 [[-0.18604964017868042, -0.547483503818512, -0... \n",
"636 [[-0.2750183045864105, -0.5264511704444885, -0... \n",
"712 [[-0.15113382041454315, -0.5002245306968689, -... \n",
"\n",
"[9 rows x 41 columns]"
]
},
"execution_count": 19,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"get_matched_df(processed_df, \"glioma\", model, threshold=0.92)"
]
},
{
"cell_type": "code",
"execution_count": 28,
"metadata": {},
"outputs": [
{
"data": {
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" <th>NCT No</th>\n",
" <th>JapicCTI No</th>\n",
" <th>Title</th>\n",
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" <th>TargetVec</th>\n",
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" <tr>\n",
" <th>82</th>\n",
" <td>jRCT2051240121</td>\n",
" <td>NCT06413706</td>\n",
" <td>NaN</td>\n",
" <td>放射線療法後の悪性神経膠腫の小児および若年成人を対象に、アベマシクリブ＋テモゾロミドとテモゾ...</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>High-Grade Glioma</td>\n",
" <td>放射線療法後の悪性神経膠腫を有する小児および若年成人を対象に、アベマシクリブとテモゾロミドの...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
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" <td>No limit</td>\n",
" <td>21age old not</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Drug: Abemaciclib Administered orally Other Na...</td>\n",
" <td>[High-Grade Glioma]</td>\n",
" <td>[[tensor(-0.1224), tensor(-0.5778), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>87</th>\n",
" <td>jRCT2051240119</td>\n",
" <td>NCT03423628</td>\n",
" <td>NaN</td>\n",
" <td>多形性膠芽腫患者及び固形がんの脳転移患者を対象に、放射線療法併用下でAZD1390を漸増投与...</td>\n",
" <td>再発多形性膠芽腫</td>\n",
" <td>再発多形性膠芽腫</td>\n",
" <td>Recurrent Glioblastoma Multiforme</td>\n",
" <td>Treatment</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Provision of formalin-fixed paraffin embedde...</td>\n",
" <td>- Administration of chemotherapy or any invest...</td>\n",
" <td>18age old over</td>\n",
" <td>130age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>AZD1390 + Radiation Therapy Drug: AZD1390 - AZ...</td>\n",
" <td>[Recurrent, Glioblastoma Multif, Me]</td>\n",
" <td>[[tensor(-0.2750), tensor(-0.5265), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>175</th>\n",
" <td>jRCT2031240090</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発悪性神経膠腫に対する治療用放射性薬剤64Cu-ATSMの有効性を検証するランダム化比較医...</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>悪性神経膠腫</td>\n",
" <td>Malignant glioma</td>\n",
" <td>再発・難治性悪性神経膠腫を対象として、64Cu-diacetyl-bis(N4-methyl...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1) Histologically diagnosed as high grade glio...</td>\n",
" <td>1) Have a history or merger of other malignanc...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>glioblastoma, grade3/4 astrocytoma, grade3 oli...</td>\n",
" <td>Group A: BPC Therapy Depending on the patient'...</td>\n",
" <td>[Malignant Glioma]</td>\n",
" <td>[[tensor(-0.3377), tensor(-0.4648), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>263</th>\n",
" <td>jRCT2041230136</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発膠芽腫に対するTUG1を標的とした核酸医薬医師主導第I相試験</td>\n",
" <td>再発膠芽腫</td>\n",
" <td>再発膠芽腫</td>\n",
" <td>recurrent glioblastoma</td>\n",
" <td>再発膠芽腫患者を対象としてTUG1ASOを投与した場合の投与時の安全性を検討し、至適投与量を...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>(1) Patients with a histological diagnosis of ...</td>\n",
" <td>(1) Patients with extracerebral metastases. (2...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Dosing frequency: 1 time /week Dose Levels Lev...</td>\n",
" <td>[Recurrent, Glioblastoma]</td>\n",
" <td>[[tensor(-0.2750), tensor(-0.5265), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>272</th>\n",
" <td>jRCT2032230554</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>初発膠芽腫に対する新型高出力中性子線源を用いた加速器BNCT装置iBNCT001及びSPM-...</td>\n",
" <td>初発膠芽腫</td>\n",
" <td>初発膠芽腫</td>\n",
" <td>Newly-diagnosed glioblastoma</td>\n",
" <td>治験機器iBNCT001及び治験薬SPM-011を用いたホウ素中性子捕捉療法(BNCT)に、...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>- Karnofsky Performance Status is greater than...</td>\n",
" <td>- Multiple lesions, bilateral lesions, dissemi...</td>\n",
" <td>18age old over</td>\n",
" <td>85age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>boron, neutron, glioblastoma</td>\n",
" <td>- Intravenous administration of investigationa...</td>\n",
" <td>[Newly-Diagnosed Glioblastoma]</td>\n",
" <td>[[tensor(-0.5050), tensor(-0.8343), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>361</th>\n",
" <td>jRCT2051230069</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>神経膠腫患者に対するロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全...</td>\n",
" <td>神経膠腫</td>\n",
" <td>神経膠腫</td>\n",
" <td>Glioma</td>\n",
" <td>神経膠腫患者におけるロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併用療法の安全...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td><Cohort 1> All of the following items shall be...</td>\n",
" <td><Common to Cohort 1 and Cohort 2> 1) Active mu...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td><cohort1> Lomustine 130 mg/m2 orally every 6 w...</td>\n",
" <td>[Glioma]</td>\n",
" <td>[[tensor(-0.2163), tensor(-0.5688), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>401</th>\n",
" <td>jRCT2032230060</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>初発IDH野生型低悪性度神経膠腫に対する交流電場腫瘍治療システムの有効性と安全性を検証する多...</td>\n",
" <td>IDH野生型神経膠腫（グレードⅢ）（退形成性星細胞腫）</td>\n",
" <td>IDH野生型神経膠腫(グレードIII)(退形成性星細胞腫)</td>\n",
" <td>IDH wild-type glioma (grade III) (anaplastic a...</td>\n",
" <td>初発IDH野生型低悪性度神経膠腫を対象に、放射線化学療法後のテモゾロミド維持療法期における交...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>At the time of enrollment, patients will be in...</td>\n",
" <td>Any of the following conditions shall not appl...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>Glioma</td>\n",
" <td>The patient using the product should shave all...</td>\n",
" <td>[Idh Wild-Type Glioma (Grade Iii) (Anaplastic ...</td>\n",
" <td>[[tensor(-0.3404), tensor(-0.5658), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>414</th>\n",
" <td>jRCT2031230007</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>BRAF融合遺伝子陽性の進行・再発の低悪性度神経膠腫または膵癌に対するビニメチニブの第Ⅱ相医...</td>\n",
" <td>低悪性度神経膠腫、膵癌</td>\n",
" <td>低悪性度神経膠腫、膵癌</td>\n",
" <td>Low-grade glioma, pancreatic cancer</td>\n",
" <td>BRAF融合遺伝子または遺伝子再構成陽性の切除不能または再発の低悪性度神経膠腫(コホート A...</td>\n",
" <td>2</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>Inclusion criteria for both cohort A and B 1) ...</td>\n",
" <td>1) Active double primary cancer (but not (1)-(...</td>\n",
" <td>12age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>BRAF fusion gene, BRAF rearrangement, low-grad...</td>\n",
" <td>Binimetinib is administered 45 mg orally, twic...</td>\n",
" <td>[Low-Grade Glioma, Pancreatic Cancer]</td>\n",
" <td>[[tensor(-0.1860), tensor(-0.5475), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>636</th>\n",
" <td>jRCT2031210299</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>再発悪性神経膠腫患者を対象としたDSP-0390の第1相試験</td>\n",
" <td>再発悪性神経膠腫</td>\n",
" <td>再発悪性神経膠腫</td>\n",
" <td>Recurrent High-Grade Glioma</td>\n",
" <td>再発悪性神経膠腫患者を対象にDSP-0390を経口投与したときの安全性、薬物動態、薬力学及び...</td>\n",
" <td>1</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>1. Estimated life expectancy >= 3 months 2. Re...</td>\n",
" <td>1. Prior therapy with bevacizumab or other ant...</td>\n",
" <td>18age old over</td>\n",
" <td>No limit</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Patients will receive DSP-0390 orally once dai...</td>\n",
" <td>[Recurrent, High-Grade Glioma]</td>\n",
" <td>[[tensor(-0.2750), tensor(-0.5265), tensor(-0....</td>\n",
" </tr>\n",
" <tr>\n",
" <th>712</th>\n",
" <td>jRCT2031200153</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Cellm-001による初発膠芽腫治療効果無作為比較対照試験</td>\n",
" <td>膠芽腫</td>\n",
" <td>膠芽腫</td>\n",
" <td>glioblastoma</td>\n",
" <td>脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術...</td>\n",
" <td>3</td>\n",
" <td>NaN</td>\n",
" <td>...</td>\n",
" <td>(1) 18 years old or older and 75 years old or ...</td>\n",
" <td>(1) Systemic administration of corticosteroids...</td>\n",
" <td>18age old over</td>\n",
" <td>75age old under</td>\n",
" <td>Both</td>\n",
" <td>NaN</td>\n",
" <td>NaN</td>\n",
" <td>Inject the investigational drug (Cellm-001 or ...</td>\n",
" <td>[Glioblastoma]</td>\n",
" <td>[[tensor(-0.1511), tensor(-0.5002), tensor(-0....</td>\n",
" </tr>\n",
" </tbody>\n",
"</table>\n",
"<p>10 rows × 41 columns</p>\n",
"</div>"
],
"text/plain": [
" JRCT ID NCT No JapicCTI No \\\n",
"82 jRCT2051240121 NCT06413706 NaN \n",
"87 jRCT2051240119 NCT03423628 NaN \n",
"175 jRCT2031240090 NaN NaN \n",
"263 jRCT2041230136 NaN NaN \n",
"272 jRCT2032230554 NaN NaN \n",
"361 jRCT2051230069 NaN NaN \n",
"401 jRCT2032230060 NaN NaN \n",
"414 jRCT2031230007 NaN NaN \n",
"636 jRCT2031210299 NaN NaN \n",
"712 jRCT2031200153 NaN NaN \n",
"\n",
" Title \\\n",
"82 放射線療法後の悪性神経膠腫の小児および若年成人を対象に、アベマシクリブ＋テモゾロミドとテモゾ... \n",
"87 多形性膠芽腫患者及び固形がんの脳転移患者を対象に、放射線療法併用下でAZD1390を漸増投与... \n",
"175 再発悪性神経膠腫に対する治療用放射性薬剤64Cu-ATSMの有効性を検証するランダム化比較医... \n",
"263 再発膠芽腫に対するTUG1を標的とした核酸医薬医師主導第I相試験 \n",
"272 初発膠芽腫に対する新型高出力中性子線源を用いた加速器BNCT装置iBNCT001及びSPM-... \n",
"361 神経膠腫患者に対するロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全... \n",
"401 初発IDH野生型低悪性度神経膠腫に対する交流電場腫瘍治療システムの有効性と安全性を検証する多... \n",
"414 BRAF融合遺伝子陽性の進行・再発の低悪性度神経膠腫または膵癌に対するビニメチニブの第Ⅱ相医... \n",
"636 再発悪性神経膠腫患者を対象としたDSP-0390の第1相試験 \n",
"712 Cellm-001による初発膠芽腫治療効果無作為比較対照試験 \n",
"\n",
" TargetJ Target \\\n",
"82 悪性神経膠腫 悪性神経膠腫 \n",
"87 再発多形性膠芽腫 再発多形性膠芽腫 \n",
"175 悪性神経膠腫 悪性神経膠腫 \n",
"263 再発膠芽腫 再発膠芽腫 \n",
"272 初発膠芽腫 初発膠芽腫 \n",
"361 神経膠腫 神経膠腫 \n",
"401 IDH野生型神経膠腫（グレードⅢ）（退形成性星細胞腫） IDH野生型神経膠腫(グレードIII)(退形成性星細胞腫) \n",
"414 低悪性度神経膠腫、膵癌 低悪性度神経膠腫、膵癌 \n",
"636 再発悪性神経膠腫 再発悪性神経膠腫 \n",
"712 膠芽腫 膠芽腫 \n",
"\n",
" TargetEnglish \\\n",
"82 High-Grade Glioma \n",
"87 Recurrent Glioblastoma Multiforme \n",
"175 Malignant glioma \n",
"263 recurrent glioblastoma \n",
"272 Newly-diagnosed glioblastoma \n",
"361 Glioma \n",
"401 IDH wild-type glioma (grade III) (anaplastic a... \n",
"414 Low-grade glioma, pancreatic cancer \n",
"636 Recurrent High-Grade Glioma \n",
"712 glioblastoma \n",
"\n",
" 研究・治験の目的 試験等のフェーズ 試験の種類 ... \\\n",
"82 放射線療法後の悪性神経膠腫を有する小児および若年成人を対象に、アベマシクリブとテモゾロミドの... 2 NaN ... \n",
"87 Treatment 1 NaN ... \n",
"175 再発・難治性悪性神経膠腫を対象として、64Cu-diacetyl-bis(N4-methyl... 3 NaN ... \n",
"263 再発膠芽腫患者を対象としてTUG1ASOを投与した場合の投与時の安全性を検討し、至適投与量を... 1 NaN ... \n",
"272 治験機器iBNCT001及び治験薬SPM-011を用いたホウ素中性子捕捉療法(BNCT)に、... 1 NaN ... \n",
"361 神経膠腫患者におけるロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併用療法の安全... 1 NaN ... \n",
"401 初発IDH野生型低悪性度神経膠腫を対象に、放射線化学療法後のテモゾロミド維持療法期における交... 2 NaN ... \n",
"414 BRAF融合遺伝子または遺伝子再構成陽性の切除不能または再発の低悪性度神経膠腫(コホート A... 2 NaN ... \n",
"636 再発悪性神経膠腫患者を対象にDSP-0390を経口投与したときの安全性、薬物動態、薬力学及び... 1 NaN ... \n",
"712 脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術... 3 NaN ... \n",
"\n",
" Inclusion Criteria \\\n",
"82 Subjects required to meet all the folloiwng cr... \n",
"87 - Provision of formalin-fixed paraffin embedde... \n",
"175 1) Histologically diagnosed as high grade glio... \n",
"263 (1) Patients with a histological diagnosis of ... \n",
"272 - Karnofsky Performance Status is greater than... \n",
"361 <Cohort 1> All of the following items shall be... \n",
"401 At the time of enrollment, patients will be in... \n",
"414 Inclusion criteria for both cohort A and B 1) ... \n",
"636 1. Estimated life expectancy >= 3 months 2. Re... \n",
"712 (1) 18 years old or older and 75 years old or ... \n",
"\n",
" Exclusion Criteria Age Minimum \\\n",
"82 Patients who meets any of the following criter... No limit \n",
"87 - Administration of chemotherapy or any invest... 18age old over \n",
"175 1) Have a history or merger of other malignanc... 18age old over \n",
"263 (1) Patients with extracerebral metastases. (2... 18age old over \n",
"272 - Multiple lesions, bilateral lesions, dissemi... 18age old over \n",
"361 <Common to Cohort 1 and Cohort 2> 1) Active mu... 18age old over \n",
"401 Any of the following conditions shall not appl... 18age old over \n",
"414 1) Active double primary cancer (but not (1)-(... 12age old over \n",
"636 1. Prior therapy with bevacizumab or other ant... 18age old over \n",
"712 (1) Systemic administration of corticosteroids... 18age old over \n",
"\n",
" Age Maximum Gender Discontinuation Criteria \\\n",
"82 21age old not NaN NaN \n",
"87 130age old under Both NaN \n",
"175 75age old under Both NaN \n",
"263 75age old under Both NaN \n",
"272 85age old under Both NaN \n",
"361 No limit Both NaN \n",
"401 No limit Both NaN \n",
"414 No limit Both NaN \n",
"636 No limit Both NaN \n",
"712 75age old under Both NaN \n",
"\n",
" Keyword \\\n",
"82 NaN \n",
"87 NaN \n",
"175 glioblastoma, grade3/4 astrocytoma, grade3 oli... \n",
"263 NaN \n",
"272 boron, neutron, glioblastoma \n",
"361 NaN \n",
"401 Glioma \n",
"414 BRAF fusion gene, BRAF rearrangement, low-grad... \n",
"636 NaN \n",
"712 NaN \n",
"\n",
" Intervention(s) \\\n",
"82 Drug: Abemaciclib Administered orally Other Na... \n",
"87 AZD1390 + Radiation Therapy Drug: AZD1390 - AZ... \n",
"175 Group A: BPC Therapy Depending on the patient'... \n",
"263 Dosing frequency: 1 time /week Dose Levels Lev... \n",
"272 - Intravenous administration of investigationa... \n",
"361 <cohort1> Lomustine 130 mg/m2 orally every 6 w... \n",
"401 The patient using the product should shave all... \n",
"414 Binimetinib is administered 45 mg orally, twic... \n",
"636 Patients will receive DSP-0390 orally once dai... \n",
"712 Inject the investigational drug (Cellm-001 or ... \n",
"\n",
" TargetWord \\\n",
"82 [High-Grade Glioma] \n",
"87 [Recurrent, Glioblastoma Multif, Me] \n",
"175 [Malignant Glioma] \n",
"263 [Recurrent, Glioblastoma] \n",
"272 [Newly-Diagnosed Glioblastoma] \n",
"361 [Glioma] \n",
"401 [Idh Wild-Type Glioma (Grade Iii) (Anaplastic ... \n",
"414 [Low-Grade Glioma, Pancreatic Cancer] \n",
"636 [Recurrent, High-Grade Glioma] \n",
"712 [Glioblastoma] \n",
"\n",
" TargetVec \n",
"82 [[tensor(-0.1224), tensor(-0.5778), tensor(-0.... \n",
"87 [[tensor(-0.2750), tensor(-0.5265), tensor(-0.... \n",
"175 [[tensor(-0.3377), tensor(-0.4648), tensor(-0.... \n",
"263 [[tensor(-0.2750), tensor(-0.5265), tensor(-0.... \n",
"272 [[tensor(-0.5050), tensor(-0.8343), tensor(-0.... \n",
"361 [[tensor(-0.2163), tensor(-0.5688), tensor(-0.... \n",
"401 [[tensor(-0.3404), tensor(-0.5658), tensor(-0.... \n",
"414 [[tensor(-0.1860), tensor(-0.5475), tensor(-0.... \n",
"636 [[tensor(-0.2750), tensor(-0.5265), tensor(-0.... \n",
"712 [[tensor(-0.1511), tensor(-0.5002), tensor(-0.... \n",
"\n",
"[10 rows x 41 columns]"
]
},
"execution_count": 28,
"metadata": {},
"output_type": "execute_result"
}
],
"source": [
"get_matched_df(processed_df, \"glioma\", model, threshold=0.9)"
]
},
{
"cell_type": "code",
"execution_count": null,
"metadata": {},
"outputs": [],
"source": []
}
],
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|