diff --git "a/dev_JRCT_api/vector_search.ipynb" "b/dev_JRCT_api/vector_search.ipynb" new file mode 100644--- /dev/null +++ "b/dev_JRCT_api/vector_search.ipynb" @@ -0,0 +1,2368 @@ +{ + "cells": [ + { + "cell_type": "code", + "execution_count": 86, + "metadata": {}, + "outputs": [], + "source": [ + "from sentence_transformers import SentenceTransformer, util\n", + "import pandas as pd\n", + "import re" + ] + }, + { + "cell_type": "code", + "execution_count": 87, + "metadata": {}, + "outputs": [], + "source": [ + "# Target列を分割する関数\n", + "def split_target(target):\n", + " # 指定された区切り文字で分割\n", + " split_words = re.split(r'[,\\n、・及びおよび又はまたは]+', target)\n", + " # 空白文字を除外してリストとして返す\n", + " return [word.strip() for word in split_words if word.strip()]" + ] + }, + { + "cell_type": "code", + "execution_count": 88, + "metadata": {}, + "outputs": [], + "source": [ + "basedf = pd.read_csv('../ClinicalTrialCSV/JRCT20241202Cancer.csv', index_col=0)\n", + "basedf = basedf.dropna(subset=['試験等のフェーズ'])\n", + "# Target列を分割してTargetWord列を追加\n", + "basedf['TargetWord'] = basedf['Target'].apply(split_target)" + ] + }, + { + "cell_type": "code", + "execution_count": 84, + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
\n", + " | JRCT ID | \n", + "NCT No | \n", + "JapicCTI No | \n", + "Title | \n", + "Target | \n", + "研究・治験の目的 | \n", + "試験等のフェーズ | \n", + "試験の種類 | \n", + "無作為化 | \n", + "盲検化 | \n", + "... | \n", + "purpose | \n", + "Inclusion Criteria | \n", + "Exclusion Criteria | \n", + "Age Minimum | \n", + "Age Maximum | \n", + "Gender | \n", + "Discontinuation Criteria | \n", + "Keyword | \n", + "Intervention(s) | \n", + "TargetWord | \n", + "
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | \n", + "jRCT2021240039 | \n", + "NCT06632951 | \n", + "NaN | \n", + "[M25-204]転移性尿路上皮癌患者を対象に,livmoniplimab とbudigal... | \n", + "尿路上皮癌 | \n", + "主要目的:全生存期間(以下「OS」)を指標として,livmoniplimab と budig... | \n", + "2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "-Participant has histologically or cytological... | \n", + "-Participant has received more than 1 prior ch... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "-Arm 1: Livmoniplimab (Dose A) + Budigalimab\\r... | \n", + "[尿路上皮癌] | \n", + "
4 | \n", + "jRCT2031240512 | \n", + "NaN | \n", + "NaN | \n", + "フッ化ピリミジン製剤及びプラチナ製剤を含む一次治療に不応・不耐となった切除不能進行・再発胃癌... | \n", + "切除不能進行・再発胃癌 | \n", + "フッ化ピリミジン・プラチナ系薬剤に不応・不耐の切除不能進行・再発胃癌被験者を対象として、ベバ... | \n", + "1 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "1)\\tAge between 18 and 75 years.\\r\\n2)\\tPerfor... | \n", + "1)\\tPrior treatment history with paclitaxel, r... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Safety Part (Dose Escalation):\\r\\nLevel 0: Bev... | \n", + "[切除不能進行, 再発胃癌] | \n", + "
7 | \n", + "jRCT2051240197 | \n", + "NCT06692738 | \n", + "NaN | \n", + "PD-L1 陽性の転移性扁平上皮非小細胞肺癌患者に対する一次治療として、Rilvegosto... | \n", + "非小細胞肺癌 | \n", + "Treatment | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "二重盲検 | \n", + "... | \n", + "treatment purpose | \n", + "- Histologically or cytologically documented s... | \n", + "- Presence of small cell and neuroendocrine hi... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Participants will be randomized in a 1:1 ratio... | \n", + "[非小細胞肺癌] | \n", + "
8 | \n", + "jRCT2031240508 | \n", + "NCT06573294 | \n", + "NaN | \n", + "悪性固形癌患者を対象にGEN1057の安全性及び抗腫瘍活性を評価するヒト初回投与、非盲検、用... | \n", + "進行性悪性固形癌\\n転移性悪性固形癌 | \n", + "本第I相試験の目的は、転移性又は進行性病変を有する悪性固形癌患者を対象に、GEN1057を単... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "-Advanced and/or metastatic solid tumors, who ... | \n", + "Has been exposed to any of the following prior... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "GEN1057 monotherapy will be administered intra... | \n", + "[進行性悪性固形癌, 転移性悪性固形癌] | \n", + "
12 | \n", + "jRCT2041240130 | \n", + "NaN | \n", + "NaN | \n", + "中等度-高度PONV発症リスクを有する肺切除術予定患者の周術期管理におけるGranisetr... | \n", + "肺がん | \n", + "全身麻酔を要する肺切除術周術期における標準制吐療法であるグラニセトロン(Granisetro... | \n", + "2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(1) Patients scheduled to undergo anatomical l... | \n", + "(1) Patients with a history of allergy to the ... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Treatment group\\r\\nAdminister GRA 1mg intraven... | \n", + "[肺がん] | \n", + "
... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "
974 | \n", + "jRCT2031200203 | \n", + "NCT04379596 | \n", + "NaN | \n", + "HER2発現の成人胃癌患者を対象としてトラスツズマブ デルクステカン(T-DXd)の単剤療法... | \n", + "胃腺癌、胃食道接合部腺癌又は食道腺癌 | \n", + "DESTINY-Gastric03は、HER2発現の進行・転移性胃癌・胃食道接合部(GEJ)... | \n", + "1-2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "1. Male and female participants must be at lea... | \n", + "1. History of active primary immunodeficiency,... | \n", + "18age old over | \n", + "130age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Experimental: Arm 1A: T-DXd and 5-fluorouracil... | \n", + "[胃腺癌, 胃食道接合部腺癌, 食道腺癌] | \n", + "
981 | \n", + "jRCT2031200153 | \n", + "NaN | \n", + "NaN | \n", + "Cellm-001による初発膠芽腫治療効果無作為比較対照試験 | \n", + "膠芽腫 | \n", + "脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "二重盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(1) 18 years old or older and 75 years old or ... | \n", + "(1) Systemic administration of corticosteroids... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Inject the investigational drug (Cellm-001 or ... | \n", + "[膠芽腫] | \n", + "
996 | \n", + "jRCT2031200087 | \n", + "NaN | \n", + "NaN | \n", + "4型進行胃癌に対する術後または周術期補助化学療法としての全身・腹腔内併用化学療法と全身化学療... | \n", + "4型進行胃癌 | \n", + "術後腹膜播種のリスクが高い4型進行胃癌を対象として、全身・腹腔内併用化学療法の全身化学療法に... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "Confirmation before temporary registration\\r\\n... | \n", + "1)\\tSimultaneously active double cancer.\\r\\n2)... | \n", + "20age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "S-1 monotherapy\\r\\noral S-1 80 mg/m2/day on da... | \n", + "[4型進行胃癌] | \n", + "
1053 | \n", + "jRCT2033190086 | \n", + "NaN | \n", + "NaN | \n", + "悪性黒色腫患者を対象としたインターロイキン12発現型遺伝子組換え単純ヘルペスウイルス1型の第... | \n", + "悪性黒色腫 | \n", + "第Ⅰ相パート:進行期の悪性黒色腫患者を対象として、ヒトIL-12発現型遺伝子組換え単純ヘルペ... | \n", + "1-2 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(Phase 1)\\r\\n1) Histologically confirmed malig... | \n", + "(Phase 1 and 2)\\r\\n1) Patients who have brain ... | \n", + "20age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "malignamt melanoma, advanced stage | \n", + "Test drug (T-hIL12) will be administered into ... | \n", + "[悪性黒色腫] | \n", + "
1067 | \n", + "jRCT2051190009 | \n", + "NCT03818893 | \n", + "JapicCTI-194618 | \n", + "進行性悪性黒色腫患者を対象としたGEN0101の皮内投与と、ペムブロリズマブ(抗PD-1抗体... | \n", + "進行性悪性黒色腫 | \n", + "抗PD-1抗体治療でSDが確定した、またはPDとなった患者を対象とし、非盲検下でGEN010... | \n", + "1-2 | \n", + "NaN | \n", + "非無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "Inclusion criteria \\r\\nPatients meeting all of... | \n", + "Exclusion criteria\\r\\nPatients meeting any of ... | \n", + "20age old over | \n", + "86age old not | \n", + "Both | \n", + "NaN | \n", + "advanced melanoma | \n", + "combination therapy of intracutaneous GEN0101 ... | \n", + "[進行性悪性黒色腫] | \n", + "
416 rows × 39 columns
\n", + "\n", + " | JRCT ID | \n", + "NCT No | \n", + "JapicCTI No | \n", + "Title | \n", + "Target | \n", + "研究・治験の目的 | \n", + "試験等のフェーズ | \n", + "試験の種類 | \n", + "無作為化 | \n", + "盲検化 | \n", + "... | \n", + "assignment | \n", + "purpose | \n", + "Inclusion Criteria | \n", + "Exclusion Criteria | \n", + "Age Minimum | \n", + "Age Maximum | \n", + "Gender | \n", + "Discontinuation Criteria | \n", + "Keyword | \n", + "Intervention(s) | \n", + "
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
67 | \n", + "jRCT2051240150 | \n", + "NCT06622941 | \n", + "NaN | \n", + "ONO-4538-126:ラブドイド腫瘍を対象としたONO-4538 の有効性及び安全性を検... | \n", + "ラブドイド腫瘍 | \n", + "ラブドイド腫瘍を対象としたONO-4538 の有効性及び安全性を検討する | \n", + "2 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "1. Gender: Not specified\\r\\n2. Age (at the tim... | \n", + "1. Patients with a history of active concurren... | \n", + "1age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "For adults, Nivolumab (recombinant) is adminis... | \n", + "
103 | \n", + "jRCT2051240121 | \n", + "NCT06413706 | \n", + "NaN | \n", + "放射線療法後の悪性神経膠腫の小児および若年成人を対象に、アベマシクリブ+テモゾロミドとテモゾ... | \n", + "悪性神経膠腫 | \n", + "放射線療法後の悪性神経膠腫を有する小児および若年成人を対象に、アベマシクリブとテモゾロミドの... | \n", + "2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "parallel assignment | \n", + "treatment purpose | \n", + "Subjects required to meet all the folloiwng cr... | \n", + "Patients who meets any of the following criter... | \n", + "No limit | \n", + "21age old not | \n", + "NaN | \n", + "NaN | \n", + "NaN | \n", + "Drug: Abemaciclib\\r\\nAdministered orally\\r\\nOt... | \n", + "
224 | \n", + "jRCT2031240090 | \n", + "NaN | \n", + "NaN | \n", + "再発悪性神経膠腫に対する治療用放射性薬剤64Cu-ATSMの有効性を検証するランダム化比較医... | \n", + "悪性神経膠腫 | \n", + "再発・難治性悪性神経膠腫を対象として、64Cu-diacetyl-bis(N4-methyl... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "parallel assignment | \n", + "treatment purpose | \n", + "1) Histologically diagnosed as high grade glio... | \n", + "1) Have a history or merger of other malignanc... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "glioblastoma, grade3/4 astrocytoma, grade3 oli... | \n", + "Group A: BPC Therapy\\r\\nDepending on the patie... | \n", + "
286 | \n", + "jRCT2071230124 | \n", + "NCT06541665 | \n", + "NaN | \n", + "ONO-4059-13:未治療の中枢神経系原発リンパ腫(PCNSL)を対象としたONO-40... | \n", + "中枢神経系原発リンパ腫 | \n", + "未治療PCNSL患者を対象にONO-4059 とR-MPV 療法を併用投与したときの忍容性及... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "1. Patients diagnosed with PCNSL\\r\\n2. Patient... | \n", + "1.Patients with intraocular PCNSL without brai... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Concomitant administration of ONO-4059 and rit... | \n", + "
321 | \n", + "jRCT2071230114 | \n", + "NCT06240741 | \n", + "NaN | \n", + "日本の神経内分泌腫瘍(NEN)患者及び健康成人を対象に[68Ga]Ga-DOTA-TATEを... | \n", + "神経内分泌腫瘍(NEN) | \n", + "神経内分泌腫瘍(NEN)患者及び健康成人(HV)を対象に,[68Ga]Ga-DOTA-TAT... | \n", + "3 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "diagnostic purpose | \n", + "1. Signed informed consent must be obtained pr... | \n", + "1. Inability to complete the needed investigat... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "[68Ga]Ga-DOTA-TATE will be administered intrav... | \n", + "
338 | \n", + "jRCT2041230136 | \n", + "NaN | \n", + "NaN | \n", + "再発膠芽腫に対するTUG1を標的とした核酸医薬医師主導第I相試験 | \n", + "再発膠芽腫 | \n", + "再発膠芽腫患者を対象としてTUG1ASOを投与した場合の投与時の安全性を検討し、至適投与量を... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "(1) Patients with a histological diagnosis of ... | \n", + "(1) Patients with extracerebral metastases.\\r\\... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Dosing frequency: 1 time /week\\r\\nDose Levels\\... | \n", + "
349 | \n", + "jRCT2032230554 | \n", + "NaN | \n", + "NaN | \n", + "初発膠芽腫に対する新型高出力中性子線源を用いた加速器BNCT装置iBNCT001及びSPM-... | \n", + "初発膠芽腫 | \n", + "治験機器iBNCT001及び治験薬SPM-011を用いたホウ素中性子捕捉療法(BNCT)に、... | \n", + "1 | \n", + "NaN | \n", + "非無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "other | \n", + "- Karnofsky Performance Status is greater than... | \n", + "- Multiple lesions, bilateral lesions, dissemi... | \n", + "18age old over | \n", + "85age old under | \n", + "Both | \n", + "NaN | \n", + "boron, neutron, glioblastoma | \n", + "- Intravenous administration of investigationa... | \n", + "
473 | \n", + "jRCT2051230069 | \n", + "NaN | \n", + "NaN | \n", + "神経膠腫患者に対するロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全... | \n", + "神経膠腫 | \n", + "神経膠腫患者におけるロムスチン療法とプロカルバジン、ロムスチン、ビンクリスチン併⽤療法の安全... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "<Cohort 1>\\r\\n All of the following items shal... | \n", + "<Common to Cohort 1 and Cohort 2>\\r\\n1) Active... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "<cohort1>\\r\\nLomustine 130 mg/m2 orally every ... | \n", + "
476 | \n", + "jRCT2021230016 | \n", + "NaN | \n", + "NaN | \n", + "皮膚血管肉腫に対するパクリタキセルとTM5614併用の安全性・有効性を検討する第Ⅱ相医師主導治験 | \n", + "皮膚血管肉腫 | \n", + "皮膚血管肉腫のパクリタキセル単剤療法無効症例を対象にTM5614とパクリタキセルの併用時にお... | \n", + "2 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "(1) Patients who are 18 years old over (at the... | \n", + "(1) Patients with concomitant or pre-existing ... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "(TM5614)\\r\\nTM5614 should be taken orally afte... | \n", + "
875 | \n", + "jRCT2031210299 | \n", + "NaN | \n", + "NaN | \n", + "再発悪性神経膠腫患者を対象としたDSP-0390の第1相試験 | \n", + "再発悪性神経膠腫 | \n", + "再発悪性神経膠腫患者を対象にDSP-0390を経口投与したときの安全性、薬物動態、薬力学及び... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "single assignment | \n", + "treatment purpose | \n", + "1.\\tEstimated life expectancy >= 3 months\\r\\n2... | \n", + "1.\\tPrior therapy with bevacizumab or other an... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Patients will receive DSP-0390 orally once dai... | \n", + "
981 | \n", + "jRCT2031200153 | \n", + "NaN | \n", + "NaN | \n", + "Cellm-001による初発膠芽腫治療効果無作為比較対照試験 | \n", + "膠芽腫 | \n", + "脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "二重盲検 | \n", + "... | \n", + "parallel assignment | \n", + "treatment purpose | \n", + "(1) 18 years old or older and 75 years old or ... | \n", + "(1) Systemic administration of corticosteroids... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Inject the investigational drug (Cellm-001 or ... | \n", + "
11 rows × 38 columns
\n", + "\n", + " | JRCT ID | \n", + "NCT No | \n", + "JapicCTI No | \n", + "Title | \n", + "Target | \n", + "研究・治験の目的 | \n", + "試験等のフェーズ | \n", + "試験の種類 | \n", + "無作為化 | \n", + "盲検化 | \n", + "... | \n", + "purpose | \n", + "Inclusion Criteria | \n", + "Exclusion Criteria | \n", + "Age Minimum | \n", + "Age Maximum | \n", + "Gender | \n", + "Discontinuation Criteria | \n", + "Keyword | \n", + "Intervention(s) | \n", + "TargetWord | \n", + "
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | \n", + "jRCT2021240039 | \n", + "NCT06632951 | \n", + "NaN | \n", + "[M25-204]転移性尿路上皮癌患者を対象に,livmoniplimab とbudigal... | \n", + "尿路上皮癌 | \n", + "主要目的:全生存期間(以下「OS」)を指標として,livmoniplimab と budig... | \n", + "2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "-Participant has histologically or cytological... | \n", + "-Participant has received more than 1 prior ch... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "-Arm 1: Livmoniplimab (Dose A) + Budigalimab\\r... | \n", + "[尿路上皮癌] | \n", + "
4 | \n", + "jRCT2031240512 | \n", + "NaN | \n", + "NaN | \n", + "フッ化ピリミジン製剤及びプラチナ製剤を含む一次治療に不応・不耐となった切除不能進行・再発胃癌... | \n", + "切除不能進行・再発胃癌 | \n", + "フッ化ピリミジン・プラチナ系薬剤に不応・不耐の切除不能進行・再発胃癌被験者を対象として、ベバ... | \n", + "1 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "1)\\tAge between 18 and 75 years.\\r\\n2)\\tPerfor... | \n", + "1)\\tPrior treatment history with paclitaxel, r... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Safety Part (Dose Escalation):\\r\\nLevel 0: Bev... | \n", + "[切除不能進行, 再発胃癌] | \n", + "
7 | \n", + "jRCT2051240197 | \n", + "NCT06692738 | \n", + "NaN | \n", + "PD-L1 陽性の転移性扁平上皮非小細胞肺癌患者に対する一次治療として、Rilvegosto... | \n", + "非小細胞肺癌 | \n", + "Treatment | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "二重盲検 | \n", + "... | \n", + "treatment purpose | \n", + "- Histologically or cytologically documented s... | \n", + "- Presence of small cell and neuroendocrine hi... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Participants will be randomized in a 1:1 ratio... | \n", + "[非小細胞肺癌] | \n", + "
8 | \n", + "jRCT2031240508 | \n", + "NCT06573294 | \n", + "NaN | \n", + "悪性固形癌患者を対象にGEN1057の安全性及び抗腫瘍活性を評価するヒト初回投与、非盲検、用... | \n", + "進行性悪性固形癌\\n転移性悪性固形癌 | \n", + "本第I相試験の目的は、転移性又は進行性病変を有する悪性固形癌患者を対象に、GEN1057を単... | \n", + "1 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "-Advanced and/or metastatic solid tumors, who ... | \n", + "Has been exposed to any of the following prior... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "GEN1057 monotherapy will be administered intra... | \n", + "[進行性悪性固形癌, 転移性悪性固形癌] | \n", + "
12 | \n", + "jRCT2041240130 | \n", + "NaN | \n", + "NaN | \n", + "中等度-高度PONV発症リスクを有する肺切除術予定患者の周術期管理におけるGranisetr... | \n", + "肺がん | \n", + "全身麻酔を要する肺切除術周術期における標準制吐療法であるグラニセトロン(Granisetro... | \n", + "2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(1) Patients scheduled to undergo anatomical l... | \n", + "(1) Patients with a history of allergy to the ... | \n", + "18age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Treatment group\\r\\nAdminister GRA 1mg intraven... | \n", + "[肺がん] | \n", + "
... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "... | \n", + "
974 | \n", + "jRCT2031200203 | \n", + "NCT04379596 | \n", + "NaN | \n", + "HER2発現の成人胃癌患者を対象としてトラスツズマブ デルクステカン(T-DXd)の単剤療法... | \n", + "胃腺癌、胃食道接合部腺癌又は食道腺癌 | \n", + "DESTINY-Gastric03は、HER2発現の進行・転移性胃癌・胃食道接合部(GEJ)... | \n", + "1-2 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "1. Male and female participants must be at lea... | \n", + "1. History of active primary immunodeficiency,... | \n", + "18age old over | \n", + "130age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Experimental: Arm 1A: T-DXd and 5-fluorouracil... | \n", + "[胃腺癌, 胃食道接合部腺癌, 食道腺癌] | \n", + "
981 | \n", + "jRCT2031200153 | \n", + "NaN | \n", + "NaN | \n", + "Cellm-001による初発膠芽腫治療効果無作為比較対照試験 | \n", + "膠芽腫 | \n", + "脳腫瘍のうち、初発悪性膠芽腫に対する自家脳腫瘍免疫賦活剤であるCellm-001について、術... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "二重盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(1) 18 years old or older and 75 years old or ... | \n", + "(1) Systemic administration of corticosteroids... | \n", + "18age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "Inject the investigational drug (Cellm-001 or ... | \n", + "[膠芽腫] | \n", + "
996 | \n", + "jRCT2031200087 | \n", + "NaN | \n", + "NaN | \n", + "4型進行胃癌に対する術後または周術期補助化学療法としての全身・腹腔内併用化学療法と全身化学療... | \n", + "4型進行胃癌 | \n", + "術後腹膜播種のリスクが高い4型進行胃癌を対象として、全身・腹腔内併用化学療法の全身化学療法に... | \n", + "3 | \n", + "NaN | \n", + "無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "Confirmation before temporary registration\\r\\n... | \n", + "1)\\tSimultaneously active double cancer.\\r\\n2)... | \n", + "20age old over | \n", + "75age old under | \n", + "Both | \n", + "NaN | \n", + "NaN | \n", + "S-1 monotherapy\\r\\noral S-1 80 mg/m2/day on da... | \n", + "[4型進行胃癌] | \n", + "
1053 | \n", + "jRCT2033190086 | \n", + "NaN | \n", + "NaN | \n", + "悪性黒色腫患者を対象としたインターロイキン12発現型遺伝子組換え単純ヘルペスウイルス1型の第... | \n", + "悪性黒色腫 | \n", + "第Ⅰ相パート:進行期の悪性黒色腫患者を対象として、ヒトIL-12発現型遺伝子組換え単純ヘルペ... | \n", + "1-2 | \n", + "NaN | \n", + "単一群 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "(Phase 1)\\r\\n1) Histologically confirmed malig... | \n", + "(Phase 1 and 2)\\r\\n1) Patients who have brain ... | \n", + "20age old over | \n", + "No limit | \n", + "Both | \n", + "NaN | \n", + "malignamt melanoma, advanced stage | \n", + "Test drug (T-hIL12) will be administered into ... | \n", + "[悪性黒色腫] | \n", + "
1067 | \n", + "jRCT2051190009 | \n", + "NCT03818893 | \n", + "JapicCTI-194618 | \n", + "進行性悪性黒色腫患者を対象としたGEN0101の皮内投与と、ペムブロリズマブ(抗PD-1抗体... | \n", + "進行性悪性黒色腫 | \n", + "抗PD-1抗体治療でSDが確定した、またはPDとなった患者を対象とし、非盲検下でGEN010... | \n", + "1-2 | \n", + "NaN | \n", + "非無作為化比較 | \n", + "非盲検 | \n", + "... | \n", + "treatment purpose | \n", + "Inclusion criteria \\r\\nPatients meeting all of... | \n", + "Exclusion criteria\\r\\nPatients meeting any of ... | \n", + "20age old over | \n", + "86age old not | \n", + "Both | \n", + "NaN | \n", + "advanced melanoma | \n", + "combination therapy of intracutaneous GEN0101 ... | \n", + "[進行性悪性黒色腫] | \n", + "
416 rows × 39 columns
\n", + "