import os, httpx, textwrap
from functools import lru_cache

_URL  = "https://api.platform.opentargets.org/api/v4/graphql"
_HDR  = {"Content-Type": "application/json", "Accept": "application/json"}
if os.getenv("OT_KEY"):                       # optional higher quota
    _HDR["Authorization"] = f"Bearer {os.getenv('OT_KEY')}"

_QUERY = textwrap.dedent("""
query Assoc($g:String!, $n:Int!) {
  associations(geneSymbol:$g, size:$n) {
    rows { score datasourceId disease { id name } target { id symbol } }
  }
}""")

@lru_cache(maxsize=512)
async def fetch_ot(sym: str, n: int = 30):
    payload = {"query": _QUERY, "variables": {"g": sym, "n": n}}
    async with httpx.AsyncClient(timeout=10, headers=_HDR) as c:
        r = await c.post(_URL, json=payload)
        r.raise_for_status()
        return r.json()["data"]["associations"]["rows"]