#!/usr/bin/env python3
"""MedGenesis – orchestrator (v4.1, context‑safe)

Runs an async pipeline that fetches literature, enriches with biomedical
APIs, and summarises via either OpenAI or Gemini.  Fully resilient:
    • HTTPS arXiv
    • 403‑proof ClinicalTrials.gov helper
    • Filters out failed enrichment calls so UI never crashes
    • Follow‑up QA passes `context=` kwarg (fixes TypeError)
"""
from __future__ import annotations

import asyncio
from typing import Any, Dict, List

# ── async fetchers ──────────────────────────────────────────────────
from mcp.arxiv    import fetch_arxiv
from mcp.pubmed   import fetch_pubmed
from mcp.nlp      import extract_keywords
from mcp.umls     import lookup_umls
from mcp.openfda  import fetch_drug_safety
from mcp.ncbi     import search_gene, get_mesh_definition
from mcp.disgenet import disease_to_genes
from mcp.mygene   import fetch_gene_info
from mcp.ctgov    import search_trials            # v2→v1 helper

# ── LLM helpers ────────────────────────────────────────────────────
from mcp.openai_utils import ai_summarize, ai_qa
from mcp.gemini       import gemini_summarize, gemini_qa

# ------------------------------------------------------------------
# LLM router
# ------------------------------------------------------------------
_DEF_LLM = "openai"

def _llm_router(name: str | None):
    if name and name.lower() == "gemini":
        return gemini_summarize, gemini_qa, "gemini"
    return ai_summarize, ai_qa, "openai"

# ------------------------------------------------------------------
# Keyword enrichment bundle (NCBI / MeSH / DisGeNET)
# ------------------------------------------------------------------
async def _enrich_keywords(keys: List[str]) -> Dict[str, Any]:
    jobs: List[asyncio.Future] = []
    for k in keys:
        jobs += [search_gene(k), get_mesh_definition(k), disease_to_genes(k)]

    res = await asyncio.gather(*jobs, return_exceptions=True)

    genes, meshes, disg = [], [], []
    for idx, r in enumerate(res):
        if isinstance(r, Exception):
            continue
        bucket = idx % 3
        if bucket == 0:
            genes.extend(r)
        elif bucket == 1:
            meshes.append(r)
        else:
            disg.extend(r)
    return {"genes": genes, "meshes": meshes, "disgenet": disg}

# ------------------------------------------------------------------
# Orchestrator main
# ------------------------------------------------------------------
async def orchestrate_search(query: str, *, llm: str = _DEF_LLM) -> Dict[str, Any]:
    """Fetch + enrich + summarise; returns dict for Streamlit UI."""
    # 1) Literature --------------------------------------------------
    arxiv_task  = asyncio.create_task(fetch_arxiv(query, max_results=10))
    pubmed_task = asyncio.create_task(fetch_pubmed(query, max_results=10))

    papers: List[Dict] = []
    for res in await asyncio.gather(arxiv_task, pubmed_task, return_exceptions=True):
        if not isinstance(res, Exception):
            papers.extend(res)

    # 2) Keyword extraction -----------------------------------------
    corpus   = " ".join(p.get("summary", "") for p in papers)
    keywords = extract_keywords(corpus)[:8]

    # 3) Enrichment fan‑out -----------------------------------------
    umls_f   = [lookup_umls(k)       for k in keywords]
    fda_f    = [fetch_drug_safety(k) for k in keywords]
    ncbi_f   = asyncio.create_task(_enrich_keywords(keywords))
    gene_f   = asyncio.create_task(fetch_gene_info(query))
    trials_f = asyncio.create_task(search_trials(query, max_studies=20))

    umls, fda, ncbi, mygene, trials = await asyncio.gather(
        asyncio.gather(*umls_f, return_exceptions=True),
        asyncio.gather(*fda_f,  return_exceptions=True),
        ncbi_f,
        gene_f,
        trials_f,
    )

    # filter out failed calls --------------------------------------
    umls = [u for u in umls if isinstance(u, dict)]
    fda  = [d for d in fda if isinstance(d, (dict, list))]

    # 4) LLM summary -------------------------------------------------
    summarize_fn, _, engine = _llm_router(llm)
    ai_summary = await summarize_fn(corpus) if corpus else ""

    # 5) Assemble payload -------------------------------------------
    return {
        "papers"         : papers,
        "umls"           : umls,
        "drug_safety"    : fda,
        "ai_summary"     : ai_summary,
        "llm_used"       : engine,
        "genes"          : (ncbi["genes"] or []) + ([mygene] if mygene else []),
        "mesh_defs"      : ncbi["meshes"],
        "gene_disease"   : ncbi["disgenet"],
        "clinical_trials": trials,
    }

# ------------------------------------------------------------------
async def answer_ai_question(question: str, *, context: str, llm: str = _DEF_LLM) -> Dict[str, str]:
    """Follow‑up QA using selected LLM (context kwarg fixed)."""
    _, qa_fn, _ = _llm_router(llm)
    return {"answer": await qa_fn(question, context=context)}