{"index":0,"text":"Cervicovaginal foetal fibronectin in the prediction of preterm labour in a low-risk population .","gene":["foetal fibronectin"],"gene_indices_start":[15],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1,"text":"Varicella-zoster virus ( VZV ) glycoprotein gI is a type 1 transmembrane glycoprotein which is one component of the heterodimeric gE : gI Fc receptor complex .","gene":["gE","type 1 transmembrane glycoprotein","gI Fc receptor","Varicella-zoster virus ( VZV ) glycoprotein gI"],"gene_indices_start":[0,52,130,135],"gene_indices_end":[46,85,132,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2,"text":"A segment of mRNA encoding the leader peptide of the CPA1 gene confers repression by arginine on a heterologous yeast gene transcript .","gene":["CPA1 gene"],"gene_indices_start":[53],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5,"text":"Insulin-like growth factor 1 ( IGF-1 ) in burn patients .","gene":["IGF-1","Insulin-like growth factor 1"],"gene_indices_start":[0,31],"gene_indices_end":[28,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7,"text":"We identify the \"M region\" of the muscle-specific Xenopus cardiac actin gene promoter from -282 to -348 as necessary for the embryonic expression of a cardiac actin-beta-globin reporter gene injected into fertilized eggs .","gene":["cardiac actin-beta-globin reporter gene","muscle-specific Xenopus cardiac actin gene promoter"],"gene_indices_start":[34,151],"gene_indices_end":[85,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":8,"text":"We found that 120 bp of the enhancer's transcriptional core becomes DNase I hypersensitive early in B-cell development .","gene":["DNase I"],"gene_indices_start":[68],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":9,"text":"Biochemical experiments have shown that CopG co-operatively associates to its target DNA at low protein : DNA ratios , completely protecting four helical turns on the same face of the double helix in both directions from the inverted repeat that constitutes the CopG primary target .","gene":["CopG","CopG"],"gene_indices_start":[40,262],"gene_indices_end":[44,266],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":13,"text":"Structure and expression of a gene from Arabidopsis thaliana encoding a protein related to SNF1 protein kinase .","gene":["SNF1","protein kinase"],"gene_indices_start":[91,96],"gene_indices_end":[95,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":14,"text":"Our results indicate that the retroplasmid reverse transcriptase is uniquely adapted to initiate cDNA synthesis by recognizing a 3' CCA sequence .","gene":["reverse transcriptase"],"gene_indices_start":[43],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":15,"text":"TNF-alpha exposure markedly increased activity of several RNA-binding proteins , especially a novel Mr 50 , 000-55 , 000 RNA-binding protein .","gene":["TNF-alpha"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":16,"text":"The LMW FGF-2 up-regulated the PKC epsilon levels by 1 . 6-fold ; by contrast the HMW isoform down-regulated the level of this PKC isotype by about 3-fold and increased the amount of PKC delta by 1 . 7-fold .","gene":["PKC isotype","PKC epsilon","LMW FGF-2","PKC delta","HMW isoform"],"gene_indices_start":[4,31,82,127,183],"gene_indices_end":[13,42,93,138,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":30,"text":"The murine Mov-34 gene : full-length cDNA and genomic organization .","gene":["murine Mov-34 gene"],"gene_indices_start":[4],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":32,"text":"To examine the basis for the apparent differences in postsegregational killing between the two E . coli strains , transformation assays were carried out to determine the relative sensitivities of the strains to the ParE toxin protein .","gene":["ParE toxin protein"],"gene_indices_start":[215],"gene_indices_end":[233],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":33,"text":"The mHIF-1 alpha structural gene is composed of 15 exons .","gene":["mHIF-1 alpha structural gene"],"gene_indices_start":[4],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":36,"text":"Very small deletions within the conserved region completely abolished transforming activity of dbl , while extensive deletion outside of this region had no effect .","gene":["dbl"],"gene_indices_start":[95],"gene_indices_end":[98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":39,"text":"The algorithm also limited TG to 20 and 64% , apoB to 6 and 20% , and Lp ( a ) to 15 and 56% , of low- and high-risk groups , respectively .","gene":["Lp ( a )","apoB"],"gene_indices_start":[46,70],"gene_indices_end":[50,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":40,"text":"Like other members of this family , the AP-4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site-specific DNA binding .","gene":["HLH motif","AP-4"],"gene_indices_start":[40,45],"gene_indices_end":[44,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":42,"text":"Two members of the Cbl family have since been defined in mammals ( c-Cbl and Cbl-b ) , one in C . elegans ( Sli-1 ) and one in Drosophila ( D-Cbl ) .","gene":["D-Cbl","Sli-1","Cbl family","c-Cbl","Cbl-b"],"gene_indices_start":[19,67,77,108,140],"gene_indices_end":[29,72,82,113,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":44,"text":"Comparisons of the four operon control regions studied indicate that the NarL heptamers are arranged with diverse orientations and spacing .","gene":["NarL heptamers"],"gene_indices_start":[73],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":47,"text":"The secondary , but not the primary , antibody responses of male C57Bl \/ 6 mice were higher among mice housed alone compared to mice housed in groups ; differences were observed for both IgM and IgG anti-KLH antibodies .","gene":["IgG anti-KLH antibodies","IgM"],"gene_indices_start":[187,195],"gene_indices_end":[190,218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":49,"text":"Demonstration of tissue lesions after intramuscular injection by determination of creatine kinase in blood .","gene":["creatine kinase"],"gene_indices_start":[82],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":50,"text":"These six amino acids are part of an amphipathic helix that is highly conserved among nuclear hormone receptors and contains the core domain of the ligand-dependent transactivation function , AF-2 .","gene":["AF-2","nuclear hormone receptors"],"gene_indices_start":[86,192],"gene_indices_end":[111,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":52,"text":"Neither mutant exhibited derepression of the silent mating type loci .","gene":["silent mating type loci"],"gene_indices_start":[45],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":53,"text":"Transcriptional activation of the chicken lysozyme gene by NF-kappa Bp65 ( RelA ) and c-Rel , but not by NF-kappa Bp50 .","gene":["chicken lysozyme gene","c-Rel","RelA","NF-kappa Bp50","NF-kappa Bp65"],"gene_indices_start":[34,59,75,86,105],"gene_indices_end":[55,72,79,91,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":60,"text":"POU-domain proteins , such as the pituitary-specific factor Pit-1 , are members of the homeodomain family of proteins which are important in development and homeostasis , acting constitutively or in response to signal-transduction pathways to either repress or activate the expression of specific genes .","gene":["homeodomain family","pituitary-specific factor Pit-1","POU-domain proteins"],"gene_indices_start":[0,34,87],"gene_indices_end":[19,65,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":61,"text":"The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor .","gene":["TCR alpha enhancer","TCF-1 alpha binding site","T-cell-specific transcription factor","TCF-1 alpha"],"gene_indices_start":[4,51,165,182],"gene_indices_end":[28,69,176,218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":62,"text":"The interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene is rapidly and potently induced in T cells in response to mitogenic stimuli .","gene":["IL-2R alpha","interleukin 2 receptor alpha-chain"],"gene_indices_start":[4,41],"gene_indices_end":[38,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":64,"text":"A mixture of human albumin 5% and hydroxy-ethyl-starch was used as a solution for dilution .","gene":["human albumin"],"gene_indices_start":[13],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":65,"text":"The localization of this proteoglycan locus in the human genome and the availability of new RFLPs provide the tools for future studies of human diseases where the HSPG2 proteoglycan gene is suspected to be involved .","gene":["HSPG2 proteoglycan gene","proteoglycan locus"],"gene_indices_start":[25,163],"gene_indices_end":[43,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":66,"text":"Several 7SL RNA-encoding sequences and various intergenic spacers were amplified from the individual HindIII fragments of about 1 . 3 and 2 . 8 kb .","gene":["HindIII fragments","7SL RNA-encoding sequences"],"gene_indices_start":[8,101],"gene_indices_end":[34,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":67,"text":"Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs ( ITAMs ) of lymphocyte Ag receptors .","gene":["Tctex-1","lymphocyte Ag receptors","ITAMs","Fyn","immunoreceptor tyrosine-based activation motifs","Fyn"],"gene_indices_start":[0,53,162,188,238,249],"gene_indices_end":[7,56,165,235,243,272],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":71,"text":"Like humans , the PITSLRE PK genes in chickens must be closely linked , based on fluorescent in situ hybridization ( FISH ) localization of these genes to a single chicken microchromosome .","gene":["PITSLRE PK genes in chickens"],"gene_indices_start":[18],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":72,"text":"PURPOSE : To evaluate the kinetics of erythropoietin ( EPO ) production and address the pathogenesis of anemia of prematurity , we measured EPO levels in infants during the first year of life .","gene":["EPO","EPO","erythropoietin"],"gene_indices_start":[38,55,140],"gene_indices_end":[52,58,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":73,"text":"Protein kinases play pivotal roles in the control of many cellular processes .","gene":["Protein kinases"],"gene_indices_start":[0],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":74,"text":"In the former cells , ets-2 was a CSF-1 immediate-early response gene , and phosphorylated ets-2 was detected after 2 to 4 h , coincident with expression of ets-2 protein .","gene":["CSF-1","ets-2","immediate-early response gene","ets-2 protein","ets-2"],"gene_indices_start":[22,34,40,91,157],"gene_indices_end":[27,39,69,96,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":75,"text":"In particular , unc-86 encodes a POU-type homeodomain protein needed for the production of the touch cells , while mec-3 encodes a LIM-type homeodomain protein needed for the differentiation of the touch cells .","gene":["unc-86","LIM-type homeodomain protein","mec-3","POU-type homeodomain protein"],"gene_indices_start":[16,33,115,131],"gene_indices_end":[22,61,120,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":78,"text":"Two new glucosidase inhibitors ( BAY m 1099 and BAY o 1248 ) were studied in volunteers and type II diabetics under various conditions .","gene":["glucosidase"],"gene_indices_start":[8],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":80,"text":"To define the number and nature of the E6 and E7 gene products expressed in BPV-1-transformed cells , we performed immunoprecipitation experiments with antisera raised to bacterially expressed BPV-1 E6 and E7 fusion proteins .","gene":["E7 gene","BPV-1 E6","E6","E7 fusion proteins"],"gene_indices_start":[39,46,193,206],"gene_indices_end":[41,53,201,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":83,"text":"Conversely , activation of Oct-3 \/ 4 promoter by RAR : RXR heterodimers was completely abolished by EAR-3 \/ COUP-TFI and by ARP-1 \/ COUP-TFII .","gene":["Oct-3 \/ 4 promoter","RXR heterodimers","EAR-3 \/ COUP-TFI","RAR","ARP-1 \/ COUP-TFII"],"gene_indices_start":[27,49,55,100,124],"gene_indices_end":[45,52,71,116,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":86,"text":"In adult tissues , it was less restricted , indicating that RAFTK expression is developmentally up-regulated .","gene":["RAFTK"],"gene_indices_start":[60],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":87,"text":"A cytosolic variant of the protein underwent efficient transphosphorylation , yet failed to activate appreciably either p70 ( S6k ) or MAP kinase following treatment with FK1012 .","gene":["p70 ( S6k )","MAP kinase"],"gene_indices_start":[120,135],"gene_indices_end":[131,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":89,"text":"Taken together , our data suggest that Rat7p \/ Nup159p is anchored within the NPC through its coiled-coil region and adjacent sequences .","gene":["Rat7p \/ Nup159p","NPC"],"gene_indices_start":[39,78],"gene_indices_end":[54,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":93,"text":"Our results indicate that RA-mediated repression of the hMGP gene is due to binding of liganded RAR \/ RXR to a novel negative RA response element .","gene":["RAR \/ RXR","RA response element","hMGP gene"],"gene_indices_start":[56,96,126],"gene_indices_end":[65,105,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":95,"text":"An AP-1 binding sequence is essential for regulation of the human alpha2 ( I ) collagen ( COL1A2 ) promoter activity by transforming growth factor-beta .","gene":["COL1A2","AP-1 binding sequence","human alpha2 ( I ) collagen","transforming growth factor-beta"],"gene_indices_start":[3,60,90,120],"gene_indices_end":[24,87,96,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":98,"text":"Both strains grew very poorly , or not at all , on nonfermentable carbon sources and exhibited , at most , only 5% of wild-type ubiquinol-cytochrome c oxidoreductase activity .","gene":["wild-type ubiquinol-cytochrome c oxidoreductase"],"gene_indices_start":[118],"gene_indices_end":[165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":100,"text":"SIT ( SHP2-interacting transmembrane adaptor protein ) is a recently identified transmembrane adaptor protein , which is expressed in lymphocytes .","gene":["SIT","SHP2-interacting transmembrane adaptor protein"],"gene_indices_start":[0,6],"gene_indices_end":[3,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":102,"text":"The putative immunity protein was detected among the [ 35S ] methionine-labelled proteins produced by minicells carrying cni cloned under lac promoter control , and when the gene was subcloned into expression vectors under the control of a bacteriophage T7 promoter .","gene":["cni","lac promoter"],"gene_indices_start":[121,138],"gene_indices_end":[124,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":103,"text":"This region includes verA , a structural gene previously shown to be required for ST biosynthesis , and 24 additional closely spaced transcripts ranging in size from 0 . 6 to 7 . 2 kb that are coordinately induced only under ST-producing conditions .","gene":["ST","verA"],"gene_indices_start":[21,82],"gene_indices_end":[25,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":104,"text":"In transformed E . coli , constitutive CAT expression is maintained when as little as 0 . 3 kilobase of DNA from the 3' end of the 1 . 6-kilobase segment is inserted in the correct orientation in front of the CAT gene .","gene":["constitutive CAT","CAT gene"],"gene_indices_start":[26,209],"gene_indices_end":[42,217],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":105,"text":"Comparison of sequences of ovine and bovine , rat and guinea-pig alpha s1-casein mRNAs has revealed a greater homology in the 3' and especially 5' non coding regions .","gene":["guinea-pig alpha s1-casein mRNAs"],"gene_indices_start":[54],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":112,"text":"To explore the functional relationship between c-fos and Rb , a eukaryotic expression plasmid was constructed containing the c-fos gene under control of the SV40 promoter complex .","gene":["c-fos gene","c-fos","Rb"],"gene_indices_start":[47,57,125],"gene_indices_end":[52,59,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":113,"text":"The neuroleptic-induced increase in central DA turnover ( an indicator for the degree of DA receptor blocking ) was found to be positively correlated with the therapeutic effect of neuroleptics and the development of hypokinetic-rigid symptoms .","gene":["DA receptor"],"gene_indices_start":[89],"gene_indices_end":[100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":116,"text":"155 aa , shares 78% identity with the analogous region of Xenopus laevis FGF3 and 72% identity with the product of the more distantly related human gene .","gene":["FGF3"],"gene_indices_start":[73],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":118,"text":"Removal of all core histone tail domains by limited trypsin proteolysis or acetylation of the core histone tails significantly relieves this inhibition and allows TFIIIA to exhibit high-affinity binding to nucleosomal DNA .","gene":["core histone","TFIIIA","core histone","trypsin"],"gene_indices_start":[15,52,94,163],"gene_indices_end":[27,59,106,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":119,"text":"Agonist-induced receptor internalization , determined as the percent of total [ 125I ] Tyr0-oCRF bound located in the acid-resistant fraction of transfected Cos 7 cells , increased with time ( 0-60 min at 37 degrees C ) for both wild-type and variant oCRF1 .","gene":["oCRF1","Tyr0-oCRF","Agonist-induced receptor"],"gene_indices_start":[0,87,251],"gene_indices_end":[24,96,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":121,"text":"Surprisingly , Northern ( RNA ) blot analysis and reverse transcriptase-PCRs performed after transfection of COS-7 or HeLa cells with these viral RNAs revealed that Y88S and Y88L RNAs replicated at only very low levels .","gene":["Y88S","Y88L RNAs"],"gene_indices_start":[165,174],"gene_indices_end":[169,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":123,"text":"The STAT protein accumulation resulting from C \/ EBP expression was tightly coupled to the morphological conversion of fibroblasts to adipocytes and represents an expression profile identical to that reported for mature adipocytes in vivo .","gene":["STAT protein","C \/ EBP"],"gene_indices_start":[4,45],"gene_indices_end":[16,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":125,"text":"RNA polymerase bound to the +10A promoter partially protects a 20 base-pair sequence from DNase I digestion upstream of the start site .","gene":["+10A promoter","RNA polymerase","DNase I"],"gene_indices_start":[0,28,90],"gene_indices_end":[14,41,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":126,"text":"Further , the ability of recombinant beta and \/ or gamma chains to function in defined biochemical assays of beta gamma activity was assessed for membrane extracts and supernatant fractions from infected Sf9 cells .","gene":["beta gamma","recombinant beta and \/ or gamma chains"],"gene_indices_start":[25,109],"gene_indices_end":[63,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":127,"text":"TRAF2 is known to associate with TRADD , and expression of a dominant-negative N-terminal deletion TRAF2 mutant was found to partially inhibit LMP1-induced JNK activation in 293 cells .","gene":["TRAF2","JNK","TRADD","TRAF2 mutant"],"gene_indices_start":[0,33,99,156],"gene_indices_end":[5,38,111,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":128,"text":"A portion of Region II also resembles part of the human c-jun oncoprotein's leucine zipper , which in turn , has been demonstrated to be the heterodimerization site between the jun and fos oncoproteins .","gene":["fos oncoproteins","c-jun","jun"],"gene_indices_start":[56,177,185],"gene_indices_end":[61,180,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":130,"text":"These results indicate that both naturally acquired and passive ( modified immune serum globulin ) antibodies to type III group B Streptococcus antigen are partially protective against intra-amniotic infection .","gene":["type III group B Streptococcus antigen"],"gene_indices_start":[113],"gene_indices_end":[151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":132,"text":"In addition to the protein-tyrosine kinase domain , p56lck possesses Src homology 2 and 3 ( SH2 and SH3 ) domains as well as a unique N-terminal region .","gene":["SH2","protein-tyrosine kinase domain","p56lck","SH3","Src homology 2 and 3"],"gene_indices_start":[19,52,69,92,100],"gene_indices_end":[49,58,89,95,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":136,"text":"We have isolated a cDNA encoding human MEKK3 .","gene":["human MEKK3"],"gene_indices_start":[33],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":137,"text":"Human acid ceramidase ( ( AC ) N-acylsphingosine amidohydrolase , EC 3 . 5 .","gene":["EC 3 . 5","Human acid ceramidase ( ( AC ) N-acylsphingosine amidohydrolase"],"gene_indices_start":[0,66],"gene_indices_end":[63,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":141,"text":"The only isolate of Aeromonas hydrophila produced cytotoxic enterotoxin and was invasive .","gene":["enterotoxin"],"gene_indices_start":[60],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":144,"text":"Our results indicate that the KRAB domain present in the non-finger region of many ZFP genes quenches transcription possibly due to specific protein-protein interactions between the KRAB-A domain and components of the proximal transcriptional apparatus .","gene":["ZFP genes","KRAB domain","KRAB-A domain"],"gene_indices_start":[30,83,182],"gene_indices_end":[41,92,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":150,"text":"Additionally , deletion analysis of the UCP2 promoter-PLAP constructs indicated that the minimal region exhibiting the promoter activity was located between nt -33 and +100 , and that a strong enhancer was present within 601 bp of the 5'-promoter region .","gene":["UCP2 promoter-PLAP constructs"],"gene_indices_start":[40],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":152,"text":"Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia .","gene":["Epidermal growth factor receptor","vascular endothelial growth factor","phosphatidylinositol 3'-kinase"],"gene_indices_start":[0,64,162],"gene_indices_end":[32,98,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":153,"text":"A candidate gene for Bcg , designated natural resistance-associated macrophage protein ( Nramp ) , has been isolated and shown to encode a novel macrophage-specific membrane protein , which is altered in susceptible animals .","gene":["Nramp","natural resistance-associated macrophage protein","Bcg"],"gene_indices_start":[21,38,89],"gene_indices_end":[24,86,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":155,"text":"Connector enhancer of KSR ( CNK ) is a multidomain protein required for RAS signaling .","gene":["CNK","Connector enhancer of KSR","RAS"],"gene_indices_start":[0,28,72],"gene_indices_end":[25,31,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":158,"text":"They also occur in similar locations in the promoters of several other ribosomal protein genes .","gene":["ribosomal protein genes"],"gene_indices_start":[71],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":159,"text":"In the present work , the complete genome sequences of Pyrococcus horikoshii and Pyrococcus abyssi , two species in a genus of hyperthermophilic archaeon ( archaebacterium ) , were compared to detect large genome polymorphisms linked with restriction-modification gene homologs .","gene":["restriction-modification gene homologs"],"gene_indices_start":[239],"gene_indices_end":[277],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":162,"text":"The lemdr1 gene was cloned in the expression vector pALTNEO and transfected into wild-type L . enriettii and the resulting transfected cells were resistant to vinblastine but at lower levels than in the selected mutant cells .","gene":["lemdr1 gene"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":163,"text":"The predicted amino acid sequence is 78 . 0% identical to the cytoplasmic dynein heavy chain of Neurospora crassa , 70 . 2% identical to that of Aspergillus nidulans and 24 . 8% identical to that of Saccharomyces cerevisiae .","gene":["cytoplasmic dynein heavy chain of Neurospora crassa"],"gene_indices_start":[62],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":164,"text":"Dose standardisation of botulinum toxin .","gene":["botulinum toxin"],"gene_indices_start":[24],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":165,"text":"These cells produced P2Y ( 11 ) mRNA during culture .","gene":["P2Y ( 11 ) mRNA"],"gene_indices_start":[21],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":166,"text":"In contrast , an amino-terminal fragment containing the C \/ H1 domain was sufficient for coactivation of Zta transcription and viral reactivation function .","gene":["C \/ H1 domain","Zta"],"gene_indices_start":[56,105],"gene_indices_end":[69,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":169,"text":"The inhibition of StAR gene transcription by DAX-1 was dose-dependent reducing transcription to 6% of control levels .","gene":["StAR gene","DAX-1"],"gene_indices_start":[18,45],"gene_indices_end":[27,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":172,"text":"Taken together , these results suggest that silymarin may exert a strong anticarcinogenic effect against PCA and that this effect is likely to involve impairment of erbB1-SHC-mediated signaling pathway , induction of CDKIs , and a resultant G1 arrest .","gene":["CDKIs"],"gene_indices_start":[217],"gene_indices_end":[222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":174,"text":"We further show that proteolytic targeting by calpain II and the proteasome involves different structural elements of YY1 .","gene":["YY1","calpain II"],"gene_indices_start":[46,118],"gene_indices_end":[56,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":176,"text":"Like their yeast counterpart , the mouse GCN2 isoforms contain HisRS-related sequences juxtaposed to the kinase catalytic domain .","gene":["HisRS-related sequences","GCN2"],"gene_indices_start":[41,63],"gene_indices_end":[45,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":179,"text":"In endemic BL , the RB2 \/ p130 gene is mutated in most of the cases , and the protein is restricted to the cytoplasm .","gene":["RB2","p130"],"gene_indices_start":[20,26],"gene_indices_end":[23,30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":180,"text":"French bean contains a small family of genes encoding PAL and two of these genes , PAL2 and PAL3 , have been shown to be differentially expressed at the mRNA level in bean tissues .","gene":["genes encoding PAL","PAL3","PAL2"],"gene_indices_start":[39,83,92],"gene_indices_end":[57,87,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":181,"text":"The avian cellular homolog of the oncogene jun .","gene":["oncogene jun"],"gene_indices_start":[34],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":184,"text":"A total of 7 ( 4 males and 3 females ) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA \/ CA 19-9 monoclonal antibodies .","gene":["CEA \/ CA"],"gene_indices_start":[170],"gene_indices_end":[178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":185,"text":"Patients with detectable serum TNF levels had significantly lower serum T3 concentrations compared to those with undetectable levels [ 1 . 072 + \/ - 0 . 588 vs .","gene":["TNF"],"gene_indices_start":[31],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":187,"text":"Sodium dodecyl sulphate-induced cleavage by eukaryotic topoisomerase I is known to yield enzyme covalently attached to the 3' cut end of the DNA .","gene":["eukaryotic topoisomerase I"],"gene_indices_start":[44],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":190,"text":"Overexpression of CARP in cardiomyocytes suppresses cardiac troponin C and atrial natriuretic factor transcription .","gene":["CARP","cardiac troponin C","atrial natriuretic factor"],"gene_indices_start":[18,52,75],"gene_indices_end":[22,70,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":191,"text":"It contained seven extra amino acids of FVVLNLQ ; this short stretch of extra sequence was found between Gln ( 421 ) and Phe ( 422 ) within the SET ( Suvar3-9 , Enhancer-of-zeste , Trithorax ) interacting domain ( SID ) of rMTM .","gene":["SET","SID","FVVLNLQ","Suvar3-9 , Enhancer-of-zeste , Trithorax","rMTM"],"gene_indices_start":[40,144,150,214,223],"gene_indices_end":[47,147,190,217,227],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":192,"text":"Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy .","gene":["recombinant human erythropoietin"],"gene_indices_start":[55],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":193,"text":"Circulating platelets may be activated by exposed triple-helical collagen in atherosclerotic lesions in Mg-deficient ruminants .","gene":["collagen"],"gene_indices_start":[65],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":194,"text":"Elevated maternal alpha fetoproteins and oligoamnios : fetal prognosis .","gene":["maternal alpha fetoproteins"],"gene_indices_start":[9],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":195,"text":"These analyses demonstrate that the dUTPase isoforms are encoded by the same gene with isoform-specific transcripts arising through the use of alternative 5' exons .","gene":["dUTPase"],"gene_indices_start":[36],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":196,"text":"Overexpression of the bZip interaction domain of CBP specifically abolishes the positive cross talk between TR and p45 \/ NF-E2 .","gene":["CBP","TR","p45 \/ NF-E2"],"gene_indices_start":[49,108,115],"gene_indices_end":[52,110,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":198,"text":"The phi AP3 factor is a nuclear phosphoprotein ; the extent of its phosphorylation is regulated during the cell cycle .","gene":["phi AP3 factor"],"gene_indices_start":[4],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":201,"text":"One member of this multigene family , GATA-3 , is most abundantly expressed in T lymphocytes , a cellular target for human immunodeficiency virus type 1 ( HIV-1 ) infection and replication .","gene":["GATA-3"],"gene_indices_start":[38],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":203,"text":"A crucial transcription factor in this process is STAT6 , which binds to a specific DNA element upon cytokine activation .","gene":["STAT6"],"gene_indices_start":[50],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":204,"text":"Using Ki-ras-transformed 3T3 cells as a model system , we show that both RA and the 'dissociating' retinoids inhibit anchorage-independent cell proliferation , suggesting that retinoid-induced growth inhibition may be related to AP1 transrepression .","gene":["AP1"],"gene_indices_start":[229],"gene_indices_end":[232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":206,"text":"Altogether , our results indicate that the transcriptional activity of Cut proteins is modulated by PKC .","gene":["PKC","Cut proteins"],"gene_indices_start":[71,100],"gene_indices_end":[83,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":209,"text":"We have previously mapped the defect in RIIIS \/ J to distal mouse Chr 11 , distinct from the Vwf locus on Chr 6 .","gene":["Vwf locus"],"gene_indices_start":[93],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":210,"text":"Plasma renin activity rose and the plasma aldosterone level fell after taking lisinopril .","gene":["Plasma renin"],"gene_indices_start":[0],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":212,"text":"Retroviral transduction of T \/ T ( L ) causes a rapidly fatal myeloproliferative disease in a murine bone marrow transplant ( BMT ) model , whereas T \/ T ( F ) causes a long-latency , pre-B-cell lymphoblastic lymphoma .","gene":["T \/ T ( L )","T \/ T ( F )"],"gene_indices_start":[27,148],"gene_indices_end":[38,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":214,"text":"The mutant allele of the alpha 1-tubulin gene was designated tua1-1 .","gene":["alpha 1-tubulin gene","tua1-1"],"gene_indices_start":[25,61],"gene_indices_end":[45,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":216,"text":"Similarly approximately 300 bp of sequence downstream of the translation terminator TGA of the beta-tubulin 2 ( BTU2 ) gene could substitute for the 3' region of the H4-I gene .","gene":["BTU2","H4-I gene","beta-tubulin 2"],"gene_indices_start":[95,112,166],"gene_indices_end":[109,116,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":218,"text":"Furthermore , the soluble forms of ATF6 and the G13 gene product are unable to bind to several point mutants of the cis-acting ER stress response element in vitro that hardly respond to ER stress in vivo .","gene":["ER stress response element","G13 gene product","ATF6"],"gene_indices_start":[35,48,127],"gene_indices_end":[39,64,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":221,"text":"The first one is a TPA-responsive element that controls the base-line ST3 promoter activity but is not required for its activation .","gene":["ST3 promoter","TPA-responsive element"],"gene_indices_start":[19,70],"gene_indices_end":[41,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":222,"text":"Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins .","gene":["A-kinase","Cyclic AMP-dependent protein kinase"],"gene_indices_start":[0,47],"gene_indices_end":[35,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":223,"text":"RESULTS : In the pregnant group , serum PP14 concentrations were markedly increased after ET , and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET ( p < 0 . 01 ) .","gene":["PP14"],"gene_indices_start":[40],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":224,"text":"Paf1p may therefore be required for both positive and negative regulation of subsets of yeast genes .","gene":["Paf1p"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":226,"text":"We have initiated studies to identify candidate signal transducers that associate with the cytosolic domain ( cd ) of the IL-1R .","gene":["IL-1R"],"gene_indices_start":[122],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":227,"text":"To test whether or not SOCS-3 also binds to the IGFIR , we cloned human SOCS-3 by reverse transcription-polymerase chain reaction from human skeletal muscle mRNA .","gene":["IGFIR","human SOCS-3","SOCS-3"],"gene_indices_start":[23,48,66],"gene_indices_end":[29,53,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":228,"text":"The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS-related infection is high .","gene":["CD4"],"gene_indices_start":[4],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":229,"text":"Platelet counts and function as well as fibrinogen and von Willebrand factor ( vWF ) levels were determined in each sample .","gene":["vWF","von Willebrand factor","fibrinogen"],"gene_indices_start":[40,55,79],"gene_indices_end":[50,76,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":231,"text":"The absence of other regions of hybridization suggests that there are no closely related sequences ( e . g . , reverse transcribed pseudogenes ) scattered throughout the genome and that if there are closely related genes , they must be clustered near GSTT2 .","gene":["GSTT2"],"gene_indices_start":[251],"gene_indices_end":[256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":233,"text":"Cdk2 and MAPK precipitates from untreated tumor lysates phosphorylated recombinant wild-type p27 but not the T187A mutant in vitro .","gene":["recombinant wild-type p27","Cdk2","MAPK"],"gene_indices_start":[0,9,71],"gene_indices_end":[4,13,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":234,"text":"Ribonuclease protection assays revealed that hmg1 and hmg2 are differentially expressed in a developmentally- and spatially-modulated manner during morphogenesis of specialized terpenoid-containing pigment glands in embryos .","gene":["Ribonuclease","hmg2","hmg1"],"gene_indices_start":[0,45,54],"gene_indices_end":[12,49,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":237,"text":"Taken together , our data suggest that Dbf8p plays an essential role in chromosome segregation .","gene":["Dbf8p"],"gene_indices_start":[39],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":238,"text":"The HOI induced a nearly fourfold increase in ANF in the elderly , whereas that for the young was threefold .","gene":["ANF"],"gene_indices_start":[46],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":242,"text":"Subcutaneous administration of the somatostatin analogue , octreotide , 100 micrograms thrice daily , resulted in a sustained improvement in diarrhoea and disappearance of faecal incontinence without reducing calcitonin levels .","gene":["somatostatin","calcitonin"],"gene_indices_start":[35,209],"gene_indices_end":[47,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":244,"text":"Total serum calcium was 7 . 8 + \/ - 0 . 8 mg \/ dl , whereas ionized calcium was 5 . 7 + \/ - 0 . 7 mg \/ dl , phosphorus 3 . 2 + \/ - 1 . 2 mg \/ dl , and alkaline phosphatase 149 + \/ - 48 . 6 U \/ liter .","gene":["alkaline phosphatase"],"gene_indices_start":[151],"gene_indices_end":[171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":245,"text":"CONCLUSION : TNF alpha , TGF beta , PDGF and IL-1beta increased LDLr gene expression by increasing sterol-independent and mitogenesis-independent gene transcription .","gene":["TGF beta","TNF alpha","IL-1beta","LDLr gene","PDGF"],"gene_indices_start":[13,25,36,45,64],"gene_indices_end":[22,33,40,53,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":248,"text":"Reporter constructs function in a parallel manner , demonstrating the key role of the AhR in constitutive as well as TCDD-induced expression of Cyp1B1 in mouse embryo fibroblasts .","gene":["AhR","Cyp1B1"],"gene_indices_start":[86,144],"gene_indices_end":[89,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":251,"text":"Pmt2 is a member of a six-protein family in yeast that catalyzes the first step in O mannosylation of target proteins .","gene":["Pmt2"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":252,"text":"Promoter activity was high in cell lines that expressed high levels of endogenous D3 mRNA , as indicated by Northern blot analyses , and was significantly reduced when the promoter was truncated to -122 bp .","gene":["D3 mRNA"],"gene_indices_start":[82],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":253,"text":"Sequencing analysis has shown that each rap1t allele contains a nonsense mutation within a discrete region between amino acids 663 and 684 .","gene":["rap1t allele"],"gene_indices_start":[40],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":254,"text":"This protein is present in both HeLa nuclear extracts and S100 extracts but absent from SR protein preparations , suggesting that it is not a classical SR protein .","gene":["SR protein","SR protein"],"gene_indices_start":[88,152],"gene_indices_end":[98,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":256,"text":"Alternating proline \/ alanine sequence of beta B1 subunit originates from a repetitive DNA sequence .","gene":["beta B1 subunit"],"gene_indices_start":[42],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":257,"text":"The distribution and organization of projections from the spinal cervical enlargement to subnucleus reticularis dorsalis ( SRD ) and the neighbouring Cuneate nucleus ( Cu ) area was studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin ( PHA-L ) into different laminae around the C7 level .","gene":["PHA-L","Phaseolus vulgaris leucoagglutinin"],"gene_indices_start":[229,266],"gene_indices_end":[263,271],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":258,"text":"Retreatment of these 2 dogs resulted in a similar , but blunted , response to human immunoglobulin .","gene":["human immunoglobulin"],"gene_indices_start":[78],"gene_indices_end":[98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":259,"text":"Cloning and sequence analyses revealed a second cDNA with a 95-nt deletion in the region coding for the putative second intracellular loop and the fourth transmembrane domain of the 5-HT2C-R .","gene":["5-HT2C-R"],"gene_indices_start":[182],"gene_indices_end":[190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":266,"text":"Among six different library isolates containing 6 . 5- to 7-kb IAP units , some restriction sites were highly conserved whereas others varied in both occurrence and position .","gene":["6 . 5- to 7-kb IAP units"],"gene_indices_start":[48],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":268,"text":"Mutation of the octamer element also significantly reduced the ability of HDAC1 to confer repression of inducible HLA-DRA promoter activation .","gene":["HDAC1","HLA-DRA promoter"],"gene_indices_start":[74,114],"gene_indices_end":[79,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":272,"text":"The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation .","gene":["STAT3","human granulocyte colony-stimulating factor receptor","STAT1 homodimer"],"gene_indices_start":[42,111,125],"gene_indices_end":[94,116,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":273,"text":"The mean value of the CD79b to the CD79b internally deleted ratio was 0 . 64 + \/ - 0 . 20 SD in normal donors and 0 . 44 + \/ - 0 . 27 SD in B-CLL ( P = . 01 ) .","gene":["CD79b","CD79b"],"gene_indices_start":[22,35],"gene_indices_end":[27,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":274,"text":"Amino acid sequence of one human liver clone ( HL-14 ) was identical to the rabbit skeletal muscle phosphatase 2A cDNA ( with 97% nucleotide identity ) .","gene":["rabbit skeletal muscle phosphatase 2A cDNA"],"gene_indices_start":[76],"gene_indices_end":[118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":275,"text":"Factor XI deficiency is a rare hereditary bleeding disorder affecting the intrinsic pathway .","gene":["Factor XI"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":280,"text":"Consistent with this , we show that peptides representing docking sites within the target substrates Elk-1 and p90 ( rsk ) inhibit ERK-dependent activation of MKP-3 .","gene":["Elk-1","p90 ( rsk )","MKP-3"],"gene_indices_start":[101,111,159],"gene_indices_end":[106,122,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":286,"text":"Light microscopical and routine immunohistochemical studies of a cervical neoplasm in a 32 year old woman initially suggested a histiocytic lymphoma , but histochemical staining for chloroacetate esterase established the correct diagnosis .","gene":["chloroacetate esterase"],"gene_indices_start":[182],"gene_indices_end":[204],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":287,"text":"All of the newly acquired proviruses identified in mosaic founder SWR \/ J-RF \/ J mice that could be transmitted through the germ line were also present in somatic tissues , demonstrating that viral integration occurred before the germ line was set aside from the somatic lineages .","gene":["SWR \/ J-RF \/ J"],"gene_indices_start":[66],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":292,"text":"This study was designed to compare the efficacy of efegatran plus streptokinase versus heparin plus accelerated tissue plasminogen activator ( TPA ) in coronary reperfusion in acute MI .","gene":["streptokinase","TPA","tissue plasminogen activator"],"gene_indices_start":[66,112,143],"gene_indices_end":[79,140,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":293,"text":"Based on the current literature , the mechanisms involved in the toxicity of OA indicate three major effects : ( 1 ) inhibition of mitochondrial respiration correlated with a depletion of ATP ; ( 2 ) inhibition of tRNA-synthetase accompanied by a reduced protein synthesis ; and ( 3 ) enhanced lipid peroxidation .","gene":["tRNA-synthetase"],"gene_indices_start":[214],"gene_indices_end":[229],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":294,"text":"And , most importantly , reconstitution of a consensus CRE , within the 21-bp enhancers increases binding of CREB \/ ATF proteins but abrogates basal repression of LTR-directed transcription in vitro .","gene":["CREB \/ ATF proteins","ATF","consensus CRE"],"gene_indices_start":[45,109,116],"gene_indices_end":[58,113,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":300,"text":"Activation of nuclear factor ( NF ) -kappaB and subsequent proinflammatory gene expression in human airway epithelial cells can be evoked by oxidative stress .","gene":["nuclear factor ( NF ) -kappaB"],"gene_indices_start":[14],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":301,"text":"A cAMP-responsive element-like ( CRE-like , TGACGTGA ) promoter sequence and a protein kinase A signaling pathway are involved in this induction , and activation of both CRE binding protein ( CREB ) and activating transcription factor-2 ( ATF-2 ) is required in the above process .","gene":["CRE binding protein","ATF-2","protein kinase A","cAMP-responsive element-like","TGACGTGA","activating transcription factor-2","CRE-like","CREB"],"gene_indices_start":[2,33,44,79,170,192,203,239],"gene_indices_end":[30,41,52,95,189,196,236,244],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":303,"text":"Similarly , we examined whether the ELK1 , SAP1a , FLI1 , EWS-FLI1 , ETS1 , ETS2 , PEA3 and PU . 1 proteins can form ternary complexes with SRF on the Egr1 SREI and II .","gene":["EWS-FLI1","Egr1","SRF","ETS2","ETS1","SREI and II","SAP1a","FLI1","PU . 1 proteins","ELK1","PEA3"],"gene_indices_start":[36,43,51,58,69,76,83,92,140,151,156],"gene_indices_end":[40,48,55,66,73,80,87,107,143,155,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":304,"text":"In Arabidopsis , the induction of a dehydration-responsive gene , rd22 , is mediated by abscisic acid ( ABA ) and requires protein biosynthesis for ABA-dependent gene expression .","gene":["ABA-dependent gene","dehydration-responsive gene","rd22"],"gene_indices_start":[36,66,148],"gene_indices_end":[63,70,166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":307,"text":"This resulted in a complete inhibition of Site-1 cleavage that was restored by concomitant overexpression of full-length SCAP .","gene":["SCAP"],"gene_indices_start":[121],"gene_indices_end":[125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":310,"text":"The functional homology of Cwg2 with Cdc43 , which has been implicated in the control of cell polarity , suggests a link between two morphogenetic events such as establishment of cell polarity and cell wall biosynthesis .","gene":["Cdc43","Cwg2"],"gene_indices_start":[27,37],"gene_indices_end":[31,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":311,"text":"Using anchored PCR , a VL element rearranged to CL2 was isolated .","gene":["VL element","CL2"],"gene_indices_start":[23,48],"gene_indices_end":[33,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":312,"text":"The Schistosoma mansoni homologue ( SmSmad2 ) was overexpressed in bacteria as a Sj26-GST fusion protein and used to raise specific antibodies .","gene":["SmSmad2","Schistosoma mansoni homologue","Sj26-GST fusion protein"],"gene_indices_start":[4,36,81],"gene_indices_end":[33,43,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":315,"text":"Coexposure to FP also resulted in a more pronounced and sustained activation of the mitogen-activated protein kinase kinase \/ extracellular signal-regulated protein kinase cascade after PMA treatment , although disruption of this pathway by the mitogen-activated protein kinase kinase 1 inhibitor U0126 did not prevent potentiation of apoptosis .","gene":["mitogen-activated protein kinase kinase \/ extracellular signal-regulated protein kinase","mitogen-activated protein kinase kinase 1"],"gene_indices_start":[84,245],"gene_indices_end":[171,286],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":317,"text":"We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease ( n = 81 ) or with persistent generalized lymphadenopathy ( n = 172 ) in a prospective study to evaluate clinical progression to AIDS related complex ( ARC ) or AIDS and to identify factors of possible prognostic relevance .","gene":["HIV-antibody"],"gene_indices_start":[16],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":318,"text":"Functional tests using a reporter gene , containing Stat5-binding elements , confirmed that while the variant form was inactive by itself , it could inhibit the function of the full-length receptor .","gene":["Stat5-binding elements"],"gene_indices_start":[52],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":319,"text":"The monkey LHR cDNA displayed 83-94% overall sequence homology with the other mammalian LHR cDNAs .","gene":["mammalian LHR cDNAs","monkey LHR cDNA"],"gene_indices_start":[4,78],"gene_indices_end":[19,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":321,"text":"Removal of beta 2-microglobulin by hemodialysis and hemofiltration : a four year follow up .","gene":["beta 2-microglobulin","beta 2-microglobulin"],"gene_indices_start":[11],"gene_indices_end":[16,31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":323,"text":"Another segment of CRL3 ( -296 to -184 ) , also displaying enhancer function , contained tandem repeated sequences ( DR-A1 and DR-A2 ) .","gene":["DR-A2","DR-A1","CRL3"],"gene_indices_start":[19,117,127],"gene_indices_end":[23,122,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":328,"text":"An overexpression of the betaAPP gene in certain areas of the AD brain has been suggested to be an important factor in the neuropathology of AD .","gene":["betaAPP gene"],"gene_indices_start":[25],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":330,"text":"Activity of acid hydrolases of peripheral blood leukocytes in focal and segmental pneumonia in children .","gene":["acid hydrolases"],"gene_indices_start":[12],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":333,"text":"His HC II activity and antigen levels were 49% and 50% , respectively , and his daughter also showed similar low levels .","gene":["HC II"],"gene_indices_start":[4],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":334,"text":"In this study , we identified four distinct E2F complexes present in aged and senescent normal , human diploid fibroblasts .","gene":["E2F complexes"],"gene_indices_start":[44],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":337,"text":"We report here on the molecular nature of an EMS-induced mutant , mn1-89 , a leaky semidominant allele of the Miniature1 ( Mn1 ) seed locus that encodes a seed-specific cell wall invertase , INCW2 .","gene":["Mn1","INCW2","Miniature1","mn1-89","seed-specific cell wall invertase"],"gene_indices_start":[66,110,123,155,191],"gene_indices_end":[72,120,126,188,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":338,"text":"These data indicate that although 218leu retains normal transactivation activity on a p53 promoter in yeast at physiological temperatures , it is not capable of normal p53 function in the presence of a 248trp allele in SNU-C5 cells .","gene":["248trp allele","p53 promoter","p53"],"gene_indices_start":[86,168,202],"gene_indices_end":[98,171,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":342,"text":"The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint .","gene":["gene MPS1"],"gene_indices_start":[59],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":344,"text":"Transfection analyses indicated that the expression of Tbxas1 is controlled by a short ( 70-bp ) positive regulatory sequence and several upstream repressive elements .","gene":["Tbxas1"],"gene_indices_start":[55],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":350,"text":"As a sequence-specific DNA binding transcription factor , p53 specifically binds to a 20-bp consensus motif 5'-PuPuPuC ( A \/ T ) ( T \/ A ) GPyPyPyPuPuPuC ( A \/ T ) ( T \/ A ) GPyPyPy-3' .","gene":["20-bp consensus motif 5'-PuPuPuC ( A \/ T ) ( T \/ A ) GPyPyPyPuPuPuC ( A \/ T ) ( T \/ A ) GPyPyPy-3'","p53"],"gene_indices_start":[58,86],"gene_indices_end":[61,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":354,"text":"Mutations in the RP2 locus at Xp11 . 3 were found in a further 10-20% of XLRP patients , as predicted from linkage studies .","gene":["RP2 locus at Xp11 . 3"],"gene_indices_start":[17],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":360,"text":"Interestingly , Csx \/ Nkx2 .","gene":["Csx \/ Nkx2"],"gene_indices_start":[16],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":362,"text":"Increased PTHRP production by a tyrosine kinase oncogene , Tpr-Met : role of the Ras signaling pathway .","gene":["PTHRP","Tpr-Met","tyrosine kinase oncogene","Ras"],"gene_indices_start":[10,32,59,81],"gene_indices_end":[15,56,66,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":364,"text":"Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose-inducible cell death .","gene":["GAL10 promoter","proapoptotic protein Bax"],"gene_indices_start":[18,66],"gene_indices_end":[42,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":365,"text":"TSA treatment , however , did not detectably alter enhancer factor binding or the positioning of nuc-1 on the majority of the chromatin templates indicating that protein acetylation and chromatin remodeling may be limiting steps that occur only on transcriptionally competent templates , or that remodeling of nuc-1 requires additional factors .","gene":["nuc-1","nuc-1"],"gene_indices_start":[97,310],"gene_indices_end":[102,315],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":367,"text":"We analyzed the modular organization of DNA polymerase beta and found that residues making contact with DNA phosphates were localized to five modules .","gene":["DNA polymerase beta"],"gene_indices_start":[40],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":369,"text":"Using various techniques , we have undertaken a systematic analysis of the natural TATA-less human DNA polymerase beta ( beta-pol ) gene promoter .","gene":["beta-pol","human DNA polymerase beta"],"gene_indices_start":[93,121],"gene_indices_end":[118,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":370,"text":"The incidence of hepatitis B antigen following transfusion was about 2 . 8 per cent .","gene":["hepatitis B antigen"],"gene_indices_start":[17],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":374,"text":"LPO and SOD levels were measured at five points before and during the operation .","gene":["SOD"],"gene_indices_start":[8],"gene_indices_end":[11],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":377,"text":"Activation of alpha 4 beta 1 with TS2 \/ 16 inhibited the cytoplasmic protrusions and cell migration but did not affect the pattern of phosphorylation .","gene":["alpha 4 beta 1","TS2 \/ 16"],"gene_indices_start":[14,34],"gene_indices_end":[28,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":379,"text":"The transposon-inactivated gene , designated pilP , is 525 bp long , potentially encoding a 19 . 1-kDa protein precursor that contains a typical membrane lipoprotein leader sequence .","gene":["pilP"],"gene_indices_start":[45],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":381,"text":"The seco-steroid hormone 1 , 25-dihydroxyvitamin D3 is known to induce the expression of a calcium binding protein termed calbindin-D28K in a variety of target tissues .","gene":["calbindin-D28K"],"gene_indices_start":[122],"gene_indices_end":[136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":383,"text":"The interferon ( IFN ) -induced double-stranded RNA ( dsRNA ) -activated Ser \/ Thr protein kinase ( PKR ) plays a role in the antiviral and antiproliferative effects of IFN .","gene":["interferon","IFN","double-stranded RNA ( dsRNA ) -activated Ser \/ Thr protein kinase","IFN","PKR"],"gene_indices_start":[4,17,32,100,169],"gene_indices_end":[14,20,97,103,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":384,"text":"Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3 \/ HDAC1 transcriptional corepressor complex .","gene":["tumor suppressor ING1","mSin3","HDAC1"],"gene_indices_start":[81,112,120],"gene_indices_end":[102,117,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":385,"text":"Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes .","gene":["transcription factor IIIB"],"gene_indices_start":[30],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":389,"text":"The codon usage is particularly marked for the gag , pol , and env genes .","gene":["gag","env genes","pol"],"gene_indices_start":[47,53,63],"gene_indices_end":[50,56,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":390,"text":"Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase .","gene":["GTPase","RCC1"],"gene_indices_start":[49,72],"gene_indices_end":[53,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":391,"text":"Position-independent expression of a human nerve growth factor-luciferase reporter gene cloned on a yeast artificial chromosome vector .","gene":["human nerve growth factor-luciferase reporter gene"],"gene_indices_start":[37],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":392,"text":"Judicious use of laboratory testing , including monitoring of CD4 cell counts , is recommended .","gene":["CD4"],"gene_indices_start":[62],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":399,"text":"We suggest that FlgN and FliT are substrate-specific flagellar chaperones that prevent oligomerization of the HAPs by binding to their helical domains before export .","gene":["FlgN","HAPs","FliT"],"gene_indices_start":[16,25,110],"gene_indices_end":[20,29,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":400,"text":"LY290181 appears to inhibit uPA promoter activation by blocking phorbol ester-stimulated binding of nuclear proteins to the uPA PEA3 \/ 12-0-tetradecanoylphorbol 13-acetate responsive element ( TRE ) .","gene":["uPA promoter","uPA","PEA3","12-0-tetradecanoylphorbol 13-acetate responsive element","TRE"],"gene_indices_start":[28,124,128,135,193],"gene_indices_end":[40,127,132,190,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":404,"text":"A transformation-competent mutant , like the wild-type E5 protein , bound the receptor and induced receptor tyrosine phosphorylation and down-regulation .","gene":["wild-type E5 protein"],"gene_indices_start":[45],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":405,"text":"The location of the IBS within the catB structural gene , the cooperativity observed in footprinting studies and phasing studies suggest that the IBS participates in the interaction of CatR with the upstream binding sites by looping out the intervening DNA .","gene":["CatR","catB structural gene"],"gene_indices_start":[35,185],"gene_indices_end":[55,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":409,"text":"Zn ( II ) coordination domain mutants of T4 gene 32 protein .","gene":["Zn ( II ) coordination domain mutants of T4 gene 32 protein"],"gene_indices_start":[0],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":410,"text":"All of the indigo-producing bacteria had an indoxyl phosphatase with a pI of 6 . 4 .","gene":["indoxyl phosphatase"],"gene_indices_start":[44],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":411,"text":"Xylose- and arabinose-containing polymers were better digested than was cellulose for both breads .","gene":["cellulose"],"gene_indices_start":[72],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":412,"text":"Saturable spermidine transport in stk2 : : lacZ mutants had an approximately fivefold-lower affinity and twofold-lower Vmax than in the parental strain .","gene":["lacZ mutants","stk2"],"gene_indices_start":[34,43],"gene_indices_end":[38,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":414,"text":"The decrease of TNF receptors by IL-4 was accompanied by down-regulation of TNF-induced activities , including cytotoxicity , caspase-3 activation , NF-kappaB and AP-1 activation , and c-Jun N-terminal kinase induction .","gene":["TNF receptors","caspase-3","IL-4","c-Jun N-terminal kinase","AP-1","NF-kappaB"],"gene_indices_start":[16,33,126,149,163,185],"gene_indices_end":[29,37,135,158,167,208],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":415,"text":"Here we report on the isolation of ICK2 , and show that it interacts with Cdc2aAt , but not with a second CDK from Arabidopsis , Cdc2bAt .","gene":["Cdc2bAt","CDK from Arabidopsis","Cdc2aAt","ICK2"],"gene_indices_start":[35,74,106,129],"gene_indices_end":[39,81,126,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":416,"text":"Rac causes uncapping of actin filaments ( F-actin ) at the plus-ends , through phosphatidylinositol 4 , 5 bisphosphate ( PIP2 ) , and eventually induces membrane ruffling .","gene":["Rac","actin filaments","F-actin"],"gene_indices_start":[0,24,42],"gene_indices_end":[3,39,49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":417,"text":"Assays of total cholesterol as well as the HDL , HDL2 , LDL , triglycerides , endothelin-1 , lipoprotein ( a ) , estradiol and FSH were also obtained at baseline before receiving ERT and after 3 months of ERT .","gene":["HDL2","lipoprotein ( a )","LDL","HDL","endothelin-1","FSH"],"gene_indices_start":[43,49,56,78,93,127],"gene_indices_end":[46,53,59,90,110,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":420,"text":"CONCLUSION : Some Gulf War veterans may have delayed , chronic neurotoxic syndromes from wartime exposure to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase .","gene":["neuropathy target esterase","butyrylcholinesterase"],"gene_indices_start":[148,174],"gene_indices_end":[169,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":423,"text":"Transcriptional regulators utilizing the POU domain DNA-binding motif have been shown to form multi-protein complexes dependent on the POU domain itself and its flexible recognition of various octamer sequence elements .","gene":["POU domain","POU domain"],"gene_indices_start":[41,135],"gene_indices_end":[51,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":424,"text":"These elements comprise a binding site for Krox proteins , one for nuclear factor 1 , an octamer motif that binds POU-homeodomain proteins , and a novel TN control element .","gene":["Krox proteins","TN control element","POU-homeodomain proteins","nuclear factor 1"],"gene_indices_start":[43,67,114,153],"gene_indices_end":[56,83,138,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":427,"text":"In this manuscript we demonstrate that two tandem Ets sites in the mouse GL alpha promoter bind the transcription factors Elf-1 and PU . 1 , and that the 3' site is essential for expression of a luciferase reporter gene driven by the GL alpha promoter .","gene":["PU . 1","GL alpha promoter","transcription factors Elf-1","tandem Ets sites","mouse GL alpha promoter","luciferase reporter gene"],"gene_indices_start":[43,67,100,132,195,234],"gene_indices_end":[59,90,127,138,219,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":429,"text":"The level of serum creatine kinase was significantly high 2 days after ESWIB , but it recovered in a week .","gene":["serum creatine kinase"],"gene_indices_start":[13],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":431,"text":"FLP and Cre recombinase function in Xenopus embryos .","gene":["Cre recombinase","FLP"],"gene_indices_start":[0,8],"gene_indices_end":[3,23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":432,"text":"We detected no effect of deleting YCL024W , either alone or in combination with deletion of GIN4 .","gene":["GIN4","YCL024W"],"gene_indices_start":[34,92],"gene_indices_end":[41,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":433,"text":"Recombinant AROM-p64 displayed high binding to single-stranded DNA and poly ( A ) homopolymers suggesting that this protein could play a role in mRNA maturation \/ metabolism .","gene":["Recombinant AROM-p64"],"gene_indices_start":[0],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":434,"text":"In our studies , we utilized HIV-1 HXB2 and HIV-1 Z2Z6 core enhancers because the Z2Z6 strain has a single point mutation flanking the right ETS-binding site .","gene":["Z2Z6 core enhancers","ETS-binding site","HXB2"],"gene_indices_start":[35,50,141],"gene_indices_end":[39,69,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":435,"text":"Four short nucleotide sequences ( boxes I to IV ) contribute to the light responsiveness of the parsley chalcone synthase promoter .","gene":["parsley chalcone synthase promoter","boxes I to IV"],"gene_indices_start":[34,96],"gene_indices_end":[47,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":436,"text":"ZEBRA and cellular AP-1 bZip activators , such as c-Fos , have homologous DNA-binding domains , and their DNA-binding specificities overlap .","gene":["AP-1 bZip activators","c-Fos","ZEBRA"],"gene_indices_start":[0,19,50],"gene_indices_end":[5,39,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":439,"text":"At the carboxyl terminus , deletion as far as residue 388 did not affect in vitro TRF . C assembly , although trans-activating activity was abolished .","gene":["TRF . C"],"gene_indices_start":[82],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":443,"text":"To this end , an expression cassette consisting of the gene for a green fluorescent protein ( GFP ) flanked at its 3' end by EAV-specific transcription-regulating sequences was constructed .","gene":["GFP","green fluorescent protein"],"gene_indices_start":[66,94],"gene_indices_end":[91,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":444,"text":"Promoter recognition algorithms identified divergent promoter elements within the CpG island , which lies between the ATM and E14 \/ NPAT genes , and provide evidence for a putative second ATM promoter located within intron 3 , immediately upstream of the first coding exon .","gene":["ATM promoter","E14 \/ NPAT genes","ATM"],"gene_indices_start":[118,126,188],"gene_indices_end":[121,142,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":446,"text":"Thus , SAG appears to control cell cycle progression in yeast by promoting ubiquitination and degradation of cell cycle regulatory proteins .","gene":["SAG"],"gene_indices_start":[7],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":451,"text":"However , five new mutation sites ( S61 , SL1 , S29 , SL11 , SL196 and SL126 ) are unique to the nrdB intron and disrupt self-splicing .","gene":["nrdB","S29","SL1","SL126","SL11","S61","SL196"],"gene_indices_start":[36,42,48,54,61,71,97],"gene_indices_end":[39,45,51,58,66,76,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":452,"text":"The murine chromosomal locations of the five NMDA receptor channel subunits , the epsilon 1 ( Grin2a ) , epsilon 2 ( Grin2b ) , epsilon 3 ( Grin2c ) , epsilon 4 ( Grin2d ) and zeta 1 ( Grinl ) subunits , were determined using an interspecific backcross mapping panel derived from crosses of [ ( C57BL \/ 6JxM . spretus ) F1xC57BL \/ 6J ] mice .","gene":["zeta 1","epsilon 1","epsilon 3","epsilon 2","Grin2a","Grin2c","NMDA receptor channel subunits","Grinl","epsilon 4","Grin2b","Grin2d"],"gene_indices_start":[45,82,94,105,117,128,140,151,163,176,185],"gene_indices_end":[75,91,100,114,123,137,146,160,169,182,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":453,"text":"Surprisingly , however , TCR-mediated tyrosine phosphorylation of phospholipase C gamma 1 remains intact in the Jurkat cells expressing the A2 \/ HCP chimera .","gene":["A2 \/ HCP","phospholipase C gamma 1"],"gene_indices_start":[66,140],"gene_indices_end":[89,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":454,"text":"Serum creatine kinase ( SCK ) was measured in ten subjects in the laboratory before and after the performance of bicycle ergometry and a lifting task .","gene":["SCK","Serum creatine kinase"],"gene_indices_start":[0,24],"gene_indices_end":[21,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":456,"text":"This indicates that under certain experimental conditions cdc2 \/ p58 and cdc2 \/ p62 may express some differences in their catalytic activity .","gene":["cdc2 \/ p62","cdc2 \/ p58"],"gene_indices_start":[58,73],"gene_indices_end":[68,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":457,"text":"Plasma histaminase in patients of bronchial asthma and the effect of prednisolone administration on it .","gene":["Plasma histaminase"],"gene_indices_start":[0],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":462,"text":"An F222W : W21F rGST A1-1 double mutant provides a direct fluorescence probe of changes in the environment of the C-terminal residue .","gene":["F222W : W21F rGST A1-1 double mutant"],"gene_indices_start":[3],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":463,"text":"Comparison of the plant nuclear tRNA 3' processing enzyme with the plant mitochondrial one suggests that both activities are different enzymes .","gene":["plant nuclear tRNA 3' processing enzyme"],"gene_indices_start":[18],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":464,"text":"DtxR is an iron-dependent sequence-specific DNA-binding protein that binds to the tox operator , an inverted-repeat nucleotide sequence located upstream from the diphtheria toxin gene .","gene":["tox operator","diphtheria toxin gene","DtxR"],"gene_indices_start":[0,82,162],"gene_indices_end":[4,94,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":465,"text":"Cerebral125 albumin was increased to similar proportions in those groups submitted to hyperosmolality .","gene":["Cerebral125 albumin"],"gene_indices_start":[0],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":468,"text":"Results from the mechanism study have revealed that YY1 is able to inhibit transactivation mediated by either AP1 or the Sp1-related protein , and YY1 suppressive activity is DNA binding dependent .","gene":["AP1","YY1","YY1","Sp1-related protein"],"gene_indices_start":[52,110,121,147],"gene_indices_end":[55,113,140,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":470,"text":"By analyzing the RanGAP activity of a series of recombinantly expressed rna1p mutant derivatives , we show that the highly acidic sequence in the C-terminal domain of both yeast proteins is indispensable for activating Ran-mediated GTP hydrolysis .","gene":["RanGAP","rna1p mutant"],"gene_indices_start":[17,72],"gene_indices_end":[23,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":471,"text":"One patients had plasma C-peptide greater than 3 pM and was therefore excluded from analysis .","gene":["plasma C-peptide"],"gene_indices_start":[17],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":472,"text":"NF-kappa B p65 , p50 , and Rel functionally synergize with C \/ EBP alpha , C \/ EBP beta , and C \/ EBP delta .","gene":["C \/ EBP delta","p65","C \/ EBP alpha","NF-kappa B","C \/ EBP beta","p50","Rel"],"gene_indices_start":[0,11,17,27,59,75,94],"gene_indices_end":[10,14,20,30,72,87,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":474,"text":"Freezing of plasma to obtain better yield of factor VIII : C .","gene":["factor VIII"],"gene_indices_start":[45],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":479,"text":"We cloned a DNA fragment encoding the N-terminal part of a protein with significant similarity to members of the LysR family of transcriptional regulators ( LTTRs ) .","gene":["LysR family of transcriptional regulators","LTTRs"],"gene_indices_start":[113,157],"gene_indices_end":[154,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":480,"text":"Advances in hemophilia treatment : a hepatitis-safe factor VIII concentrate .","gene":["factor VIII"],"gene_indices_start":[52],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":483,"text":"The remaining RAD+ cells progressed to form microcolonies ( < 30 cells ) containing aberrantly shaped inviable cells .","gene":["RAD+"],"gene_indices_start":[14],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":485,"text":"Characterization of an EcR \/ USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene .","gene":["EcR \/ USP heterodimer target site","Drosophila Lsp-2 gene"],"gene_indices_start":[23,102],"gene_indices_end":[56,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":486,"text":"Drug inhibition of whole blood aspirin esterase .","gene":["aspirin esterase"],"gene_indices_start":[31],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":488,"text":"It is related to a variety of mammalian Golgi-associated proteins and to the yeast Uso1p , an essential protein involved in docking of endoplasmic reticulum-derived vesicles to the cis-Golgi .","gene":["Uso1p"],"gene_indices_start":[83],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":492,"text":"Like Epo , HNF-4 is expressed in kidney , liver , and Hep3B cells but not in HeLa cells .","gene":["Epo","HNF-4"],"gene_indices_start":[5,11],"gene_indices_end":[8,16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":494,"text":"Null alleles of SAS4 and SAS5 bypassed the role of the Abf1p binding site of the HMR-E silencer but not the role of the ACS or Rap1p binding site .","gene":["ACS","Rap1p binding site","SAS5","Abf1p binding site","SAS4","HMR-E silencer"],"gene_indices_start":[16,25,55,81,120,127],"gene_indices_end":[20,29,73,95,123,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":496,"text":"The initial patients treated with AZQ and mitroxantrone experienced prolonged bone marrow suppression and , therefore , subsequent cohorts were treated with G-CSF , 5 micrograms \/ kg , beginning the day after completion of the third cycle of chemotherapy .","gene":["G-CSF"],"gene_indices_start":[157],"gene_indices_end":[162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":497,"text":"The basal promoter strength of constructs that contained deletions in the U5 region of the LTR was analyzed by chloramphenicol acetyltransferase ( CAT ) assays following transfection of HeLa cells or Jurkat T-cells in the presence or absence of viral transactivator tax protein .","gene":["U5 region","LTR","chloramphenicol acetyltransferase","CAT","tax"],"gene_indices_start":[74,91,111,147,266],"gene_indices_end":[83,94,144,150,269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":498,"text":"In Schizosaccharomyces pombe , the activity of the M-phase-inducing Cdc2 \/ Cdc13 cyclin-dependent kinase is inhibited by Wee1 and Mik1 tyrosine kinases , and activated by Cdc25 and Pyp3 tyrosine phosphatases .","gene":["Pyp3","Wee1","Cdc25","Cdc2 \/ Cdc13 cyclin-dependent kinase","tyrosine kinases","tyrosine phosphatases","Mik1"],"gene_indices_start":[68,121,130,135,171,181,186],"gene_indices_end":[104,125,134,151,176,185,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":505,"text":"Glutathione peroxidase in human red cells in health and disease .","gene":["Glutathione peroxidase"],"gene_indices_start":[0],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":506,"text":"It encodes a protein with three zinc fingers similar to those of the transcription factor Sp1 .","gene":["transcription factor Sp1"],"gene_indices_start":[69],"gene_indices_end":[93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":509,"text":"Enhancers containing disrupted Ets-1 binding sites were tested in transient expression assays in the murine T-cell line EL4 . E1 ; alterations in the LVb element affected constitutive enhancer activity , while mutation of either the LVb or LVc element disrupted phorbol ester-induced enhancer activity .","gene":["LVc element","Ets-1 binding sites","LVb","LVb element"],"gene_indices_start":[31,150,233,240],"gene_indices_end":[50,161,236,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":510,"text":"The presence of truncated receptor isoforms in diverse species suggests that these proteins may have important functional roles in regulating EGFR activity .","gene":["EGFR"],"gene_indices_start":[142],"gene_indices_end":[146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":512,"text":"In the final model , grade ( p = 0 . 0002 ) , peritoneal cytologic results ( p = 0 . 0002 ) , progesterone receptor status ( p = 0 . 004 ) , and age as a continuous variable ( p = 0 . 008 ) were most closely associated with disease-free survival .","gene":["progesterone receptor"],"gene_indices_start":[94],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":513,"text":"The lack of change in the ratio of the two spliced products expressed from either the normal or the 5'-rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor-specific activation of the mouse myb oncogene .","gene":["5'-rearranged myb","myb transcripts","mouse myb oncogene"],"gene_indices_start":[100,199,272],"gene_indices_end":[117,214,290],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":514,"text":"A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells .","gene":["human phosphoglycerate mutase gene","MEF-2 site"],"gene_indices_start":[9,124],"gene_indices_end":[19,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":517,"text":"Furthermore , the PH and PTB domains are highly homologous ( at least 40% identical ) to those found in insulin receptor substrates 1 , 2 , and 3 ( IRS-1 , IRS-2 , and IRS-3 ) .","gene":["PH","insulin receptor substrates 1 , 2 , and 3","IRS-3","IRS-2","IRS-1"],"gene_indices_start":[18,104,148,156,168],"gene_indices_end":[20,145,153,161,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":519,"text":"Here we report the cloning of the protein that binds to enhancer site III .","gene":["enhancer site III"],"gene_indices_start":[56],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":520,"text":"Foxp1 and Foxp2 are expressed at high levels in the lung as early as E12 . 5 of mouse development with Foxp2 expression restricted to the airway epithelium .","gene":["Foxp1","Foxp2","Foxp2"],"gene_indices_start":[0,10,103],"gene_indices_end":[5,15,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":523,"text":"The alpha inhibin promoter containing a mutated CRE was not regulated by forskolin in granulosa cells and did not bind the CREB protein .","gene":["alpha inhibin promoter","CREB protein","CRE"],"gene_indices_start":[4,48,123],"gene_indices_end":[26,51,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":524,"text":"We show also that RA represses the transcriptional activity of a reporter gene containing a TPA responding AP1 binding site driving the HSV tk promoter .","gene":["AP1 binding site","TPA","HSV tk promoter"],"gene_indices_start":[92,107,136],"gene_indices_end":[95,123,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":525,"text":"We also compared the sequence with the partly homologous products of the S . cerevisiae genes TPS2 and TSL1 which code for the larger subunits of the trehalose synthase complex and with a TSL1 homologue , TPS3 , of unknown function .","gene":["trehalose synthase complex","TSL1 homologue","TSL1","TPS3","TPS2"],"gene_indices_start":[94,103,150,188,205],"gene_indices_end":[98,107,176,202,209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":528,"text":"FDA regulations for growth factors and related products .","gene":["growth factors"],"gene_indices_start":[20],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":529,"text":"Six distinct Ets mRNAs were identified : Ets2 , Fli1 , GABPalpha , SAP1 , Elk1 , and PE1 .","gene":["Elk1","GABPalpha","SAP1","Fli1","PE1","Ets mRNAs","Ets2"],"gene_indices_start":[13,41,48,55,67,74,85],"gene_indices_end":[22,45,52,64,71,78,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":530,"text":"The histidine-tagged gene , rpoCHIS , was used to replace the wild-type allele in the chromosome of S . coelicolor and S . lividans .","gene":["rpoCHIS"],"gene_indices_start":[28],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":531,"text":"Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus .","gene":["latent membrane proteins 1 and 2A of Epstein-Barr virus"],"gene_indices_start":[118],"gene_indices_end":[173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":532,"text":"To identify these sites , the deduced amino acid sequence of the 3T3-L1 adipocyte insulin receptor of the mouse was determined .","gene":["adipocyte insulin receptor"],"gene_indices_start":[72],"gene_indices_end":[98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":533,"text":"Wild type HA-p190 induced a phenotype of rounded cells with long , beaded extensions similar to that seen when Rho function is disrupted by ADP-ribosylation .","gene":["Wild type HA-p190","Rho"],"gene_indices_start":[0,111],"gene_indices_end":[17,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":534,"text":"Following 2 . 5 Gy , HbO2 changes were minimal .","gene":["HbO2"],"gene_indices_start":[21],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":535,"text":"In summary , the data establish that the previously reported human MAdCAM-1 cDNA does indeed encode the human homologue of mouse MAdCAM-1 , despite gross dissimilarities in the MAdCAM-1 C-terminal structures .","gene":["mouse MAdCAM-1","human MAdCAM-1 cDNA","MAdCAM-1"],"gene_indices_start":[61,123,177],"gene_indices_end":[80,137,185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":536,"text":"Upstream of the dra gene an open reading frame of 313 amino acids was identified .","gene":["dra gene"],"gene_indices_start":[16],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":540,"text":"In patients who had received no previous drug treatment , log baseline plasma renin activity and change in mean blood pressure after SQ 20881 correlated significantly ( r = 0 . 651 , P less than 0 . 05 ) .","gene":["plasma renin"],"gene_indices_start":[71],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":541,"text":"We conclude that sequences outside of the hLEF HMG box mediate cell- and context-specific activation of the TCR alpha enhancer and may facilitate interactions between hLEF and other T-cell-specific factors recruited to the enhancer .","gene":["hLEF","TCR alpha enhancer","hLEF HMG box"],"gene_indices_start":[42,108,167],"gene_indices_end":[54,126,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":542,"text":"More mRNA corresponding to nagB and nagA is detected than that corresponding to the distal genes , nagC and nagD .","gene":["nagA","nagD","nagC","nagB"],"gene_indices_start":[27,36,99,108],"gene_indices_end":[31,40,103,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":543,"text":"However , its participation in collagen binding has not been shown .","gene":["collagen"],"gene_indices_start":[31],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":548,"text":"The gonadotrope-specific and regulated expression of the GnRH receptor ( GnRH-R ) gene is dependent on multiple transcription factors that interact with the noncanonical GnRH-R activating sequence ( GRAS ) , the activator protein-1 ( AP-1 ) element , and the steroidogenic factor-1 ( SF-1 ) binding site .","gene":["AP-1","activator protein-1","GnRH receptor","noncanonical GnRH-R activating sequence","steroidogenic factor-1","SF-1","GRAS","GnRH-R"],"gene_indices_start":[57,73,157,199,212,234,259,284],"gene_indices_end":[70,79,196,203,231,238,281,288],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":550,"text":"Comparison of the deduced amino acid sequences with protein sequences of T . pyriformis H2As showed only two and three differences respectively , in a total of 137 amino acids for H2A1 , and 132 amino acids for H2A2 , indicating the two genes arose before the divergence of these two species .","gene":["H2As","H2A1","H2A2"],"gene_indices_start":[88,180,211],"gene_indices_end":[92,184,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":553,"text":"These observations establish that RsmC negatively regulates rsmB transcription but positively affects RsmA production .","gene":["rsmB","RsmA","RsmC"],"gene_indices_start":[34,60,102],"gene_indices_end":[38,64,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":555,"text":"This was most pronounced during the initial phase of Erk activation .","gene":["Erk"],"gene_indices_start":[53],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":563,"text":"The fatigue exercise showed relatively high blood lactate concentration [ 12 . 5 ( SD 2 . 6 ) mmol x l ( -1 ) ] and an increase of serum creatine kinase ( CK ) activity delayed by 2 days [ 540 ( SD 407 ) U x l ( -1 ) ] .","gene":["CK","serum creatine kinase"],"gene_indices_start":[131,155],"gene_indices_end":[152,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":565,"text":"We have investigated the role of NGF in regulating gene transcription in PC12 and INS-1 cells , in order to define if there are NGF-regulated genes per se .","gene":["NGF"],"gene_indices_start":[33],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":566,"text":"Chloroplast mutator ( chm ) of Arabidopsis is a recessive nuclear mutation that causes green and white variegation in leaves and is inherited in a non-Mendelian fashion .","gene":["Chloroplast mutator","chm"],"gene_indices_start":[0,22],"gene_indices_end":[19,25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":568,"text":"As demonstrated by gel mobility shift analysis and supershift experiments , FIRE1 , located between -516 and -498 , is responsible for binding NF-Y .","gene":["NF-Y","FIRE1"],"gene_indices_start":[76,143],"gene_indices_end":[81,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":570,"text":"Electrophile Response Elements ( EpREs ) , located in 5'-flanking sequences of both the GCSh and GCSl subunit genes , are hypothesized to at least partially mediate gene induction following xenobiotic exposure .","gene":["GCSh","GCSl subunit genes","EpREs","Electrophile Response Elements"],"gene_indices_start":[0,33,88,97],"gene_indices_end":[30,38,92,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":571,"text":"Extreme potency of botulinum toxin .","gene":["botulinum toxin"],"gene_indices_start":[19],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":574,"text":"Labile LTR-binding proteins appear to be essential for c-myc hyperexpression , since both LTR-enhanced transcription and the activities of LTR-binding proteins are specifically decreased after inhibition of protein synthesis ( A .","gene":["c-myc","LTR-binding proteins","LTR-binding proteins"],"gene_indices_start":[7,55,139],"gene_indices_end":[27,60,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":577,"text":"Hepatitis B surface antigen was detected in 2 patients , with negative hepatitis C virus antibody .","gene":["Hepatitis B surface antigen","hepatitis C virus antibody"],"gene_indices_start":[0,71],"gene_indices_end":[27,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":580,"text":"CONCLUSIONS : Two consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate performed in a single office visit represent a cost-effective biopsy strategy for men presenting with an abnormal digital rectal examination and \/ or elevated serum PSA .","gene":["serum PSA"],"gene_indices_start":[260],"gene_indices_end":[269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":583,"text":"Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway .","gene":["JNK"],"gene_indices_start":[74],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":585,"text":"Those dosages that inhibited mean NTE activity in spinal cord greater than or equal to 72% and brain greater than or equal to 66% of control values within 44 hr postexposure produced marked spinal cord pathology 14 days postexposure in greater than or equal to 90% of similarly dosed animals .","gene":["NTE"],"gene_indices_start":[34],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":588,"text":"A gene homologous to the Escherichia coli dnaA gene was isolated from Pseudomonas putida and its transcription was investigated in E . coli as well as in P . putida .","gene":["Escherichia coli dnaA gene"],"gene_indices_start":[25],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":589,"text":"CONCLUSION : More than 50% of patients with perennial rhinitis and CRS do not improve after surgery , a response that may be predicted by more cells expressing IL-5 mRNA in the ethmoid sinuses .","gene":["IL-5 mRNA"],"gene_indices_start":[160],"gene_indices_end":[169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":591,"text":"Relatively large DNA rearrangements spanning the region with tandem direct repeats encoding the carboxy-terminal histone H1-like structure of AlgP were detected in several strains upon conversion from the mucoid to the nonmucoid phenotype .","gene":["carboxy-terminal histone H1-like structure","AlgP"],"gene_indices_start":[96,142],"gene_indices_end":[138,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":592,"text":"This approach places gHoxb-1 into the normal embryonic spatiotemporal context in which lab acts .","gene":["gHoxb-1"],"gene_indices_start":[21],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":594,"text":"EGFR levels were found to be elevated 5- , 3 .","gene":["EGFR"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":596,"text":"Serum levels of IgG and IgM were also raised , but contrary to the findings of other observers IgA levels were normal .","gene":["IgM","IgG","IgA"],"gene_indices_start":[16,24,95],"gene_indices_end":[19,27,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":598,"text":"The promoter region ( P1 ) corresponding to the main group of transcription initiation sites is devoid of TATA and CAAT boxes but has putative binding sites for the transcription factor SP1 and is embedded in a large G + C-rich domain of a CpG island , features shared by the promoters of constitutively expressed housekeeping genes .","gene":["transcription factor SP1"],"gene_indices_start":[165],"gene_indices_end":[189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":602,"text":"Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain .","gene":["tyrosine kinase domain","epidermal growth factor receptors"],"gene_indices_start":[39,127],"gene_indices_end":[72,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":603,"text":"Expansins are a family of proteins that catalyse long-term extension of isolated plant cell walls due to an as yet unknown biochemical mechanism .","gene":["Expansins"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":604,"text":"The patterns of early mRNA and protein expression in these seven mutants were examined , and it was found that mutation of the T' ( 135 ) acceptor site resulted in the utilization of cryptic splice sites and the generation of new T' species .","gene":["T' ( 135 ) acceptor site","T' species"],"gene_indices_start":[127,230],"gene_indices_end":[151,240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":606,"text":"Shc stimulates Ras \/ mitogen-activated protein kinase ( MAPK ) through forming a complex with Grb2 at the phosphorylated tyrosine ( Y ) residue 317 .","gene":["Grb2","Ras \/ mitogen-activated protein kinase","MAPK","Shc"],"gene_indices_start":[0,15,56,94],"gene_indices_end":[3,53,60,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":609,"text":"We describe here a Drosophila melanogaster FAK homologue , DFak56 , which maps to band 56D on the right arm of the second chromosome .","gene":["DFak56","Drosophila melanogaster FAK homologue"],"gene_indices_start":[19,59],"gene_indices_end":[56,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":611,"text":"A single N-glycosylation site present in chicken gp42 is conserved among all five of these proteins : carbohydrate analysis of gp42 revealed the presence of a complex type glycan chain at this site .","gene":["gp42","chicken gp42"],"gene_indices_start":[41,127],"gene_indices_end":[53,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":614,"text":"The distribution of the sites of recombinational resolution is inversely correlated with that of the gradient of sequence divergence , with only approximately 7% of the X recombinants resolved within the 3' third of the X blocks where two diverged Alu family repeats reside .","gene":["Alu family repeats"],"gene_indices_start":[248],"gene_indices_end":[266],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":616,"text":"First , human erythroid K562 cells stably integrated with various HS-40 mutants cis linked to a human alpha-globin promoter-growth hormone hybrid gene were analyzed by genomic footprinting and expression analysis .","gene":["HS-40 mutants","human alpha-globin promoter-growth hormone hybrid gene"],"gene_indices_start":[66,96],"gene_indices_end":[79,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":621,"text":"Ultraviolet light-induced kinin formation in human skin .","gene":["kinin"],"gene_indices_start":[26],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":622,"text":"Effect of bromazepam on growth hormone and prolactin secretion in normal subjects .","gene":["prolactin","growth hormone"],"gene_indices_start":[24,43],"gene_indices_end":[38,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":623,"text":"In this study , we have cloned a region that complements the exoenzyme S-deficient phenotype of strain 388 exs1 : : Tn1 , a chromosomal Tn1 insertional mutation .","gene":["Tn1","exs1","chromosomal Tn1 insertional mutation"],"gene_indices_start":[107,116,124],"gene_indices_end":[111,119,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":625,"text":"The BAL concentrations of the nine cytokines evaluated for the more and less affected lungs were compared : interleukin-6 ( IL-6 ) , IL-8 , IL-12 , tumor necrosis factor-alpha ( TNF-alpha ) , and interferon gamma ( IFN-gamma ) showed significant differences ( p ranged between 0 .","gene":["interferon gamma","IL-12","TNF-alpha","IFN-gamma","IL-8","IL-6","interleukin-6","tumor necrosis factor-alpha"],"gene_indices_start":[108,124,133,140,148,178,196,215],"gene_indices_end":[121,128,137,145,175,187,212,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":627,"text":"Certain spt10 spontaneous alleles are good suppressors but have a normal growth rate , suggesting that the SPT10 protein may have two distinct functions .","gene":["spt10","SPT10 protein"],"gene_indices_start":[8,107],"gene_indices_end":[13,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":630,"text":"Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation : contribution of both outside-in and inside-out signals .","gene":["N-cadherin-Fc chimera"],"gene_indices_start":[22],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":631,"text":"In contrast , gel mobility shift experiments have failed to reveal that HAP2 or HAP3 binds to domain 1 or that hap3 mutations affect the complexes bound to it .","gene":["hap3","HAP3","HAP2"],"gene_indices_start":[72,80,111],"gene_indices_end":[76,84,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":632,"text":"The PDH complex-encoding genes were identified by hybridization experiments and sequence analysis in two separate gene regions in the genome of Z . mobilis .","gene":["PDH complex-encoding genes"],"gene_indices_start":[4],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":636,"text":"A role for glycogen synthase kinase-3 in the control of gene expression .","gene":["glycogen synthase kinase-3"],"gene_indices_start":[11],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":639,"text":"Several particular features of this polypeptide fragment from the hamster lysyl-tRNA synthetase suggest that it is implicated in the assembly of that enzyme within the multisynthetase complex .","gene":["hamster lysyl-tRNA synthetase"],"gene_indices_start":[66],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":640,"text":"Identification of an AfsA homologue ( BarX ) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis , virginiamycin biosynthesis and virginiamycin M1 resistance .","gene":["AfsA homologue","BarX"],"gene_indices_start":[21,38],"gene_indices_end":[35,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":642,"text":"We observed NP \/ NMP4 \/ CIZ expression in osteocytes , osteoblasts , and chondrocytes in rat bone .","gene":["NP \/ NMP4 \/ CIZ"],"gene_indices_start":[12],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":643,"text":"Southwestern blot analysis demonstrated that this phosphoprotein can bind the kappa B element directly and specifically .","gene":["kappa B element"],"gene_indices_start":[78],"gene_indices_end":[93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":647,"text":"The Wnt signaling pathway functions reiteratively during animal development to control cell fate decisions .","gene":["Wnt"],"gene_indices_start":[4],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":649,"text":"Oseltamivir ( GS4104 ) , which can be administered orally , is the prodrug of GS4071 , a potent and selective inhibitor of influenzavirus neuraminidases .","gene":["influenzavirus neuraminidases"],"gene_indices_start":[123],"gene_indices_end":[152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":650,"text":"BACKGROUND : Defensins , also known as human neutrophil peptides , are antimicrobial peptides present in the azurophil granules of neutrophils .","gene":["human neutrophil peptides","Defensins"],"gene_indices_start":[13,39],"gene_indices_end":[22,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":651,"text":"We also show by immunogold electron microscopy immunocytochemistry that amphiphysin I is localized in the nerve terminal cytomatrix and is partially associated with endocytic intermediates .","gene":["amphiphysin I"],"gene_indices_start":[72],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":652,"text":"The human gp39 promoter .","gene":["human gp39 promoter"],"gene_indices_start":[4],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":654,"text":"The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF , Rel \/ NFkappaB , ETS , and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha .","gene":["SRF","tumor necrosis factor alpha","ETS","YY1 class transcription factors","Rel \/ NFkappaB","SCMV SNE sites"],"gene_indices_start":[4,85,91,108,118,189],"gene_indices_end":[18,88,105,111,149,216],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":658,"text":"The c-Ets-1 oncoprotein is a transcription activator that specifically binds to DNA .","gene":["c-Ets-1 oncoprotein"],"gene_indices_start":[4],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":660,"text":"Percent identities of the mouse PP2 to mouse Y1 , mouse Y4 \/ PP1 and human Y2 receptors are 53 , 42 , and 31 , respectively .","gene":["mouse Y1","mouse PP2","human Y2 receptors","mouse Y4 \/ PP1"],"gene_indices_start":[26,39,50,69],"gene_indices_end":[35,47,64,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":661,"text":"ZK7 and HZF16 genes appear to be the splice variants transcribed from the same gene .","gene":["ZK7","HZF16 genes"],"gene_indices_start":[0,8],"gene_indices_end":[3,19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":667,"text":"MEK itself is activated via serine phosphorylation by upstream activator kinases , including c-raf , mos and MEK kinase .","gene":["c-raf","mos","MEK","upstream activator kinases","MEK kinase"],"gene_indices_start":[0,54,93,101,109],"gene_indices_end":[3,80,98,104,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":668,"text":"A protein lacking the SH2 and RING finger domains has no activity , but a chimeric protein with the SH2 and RING finger domains of SLI-1 replaced by the equivalent domains of c-Cbl has activity .","gene":["SH2","c-Cbl","SLI-1","SH2"],"gene_indices_start":[22,100,131,175],"gene_indices_end":[25,103,136,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":669,"text":"Sequence analysis revealed that the MEMA protein is identical with a 160 kDa nuclear 'domain rich in serines' ( DRS ) protein occurring free in the nucleoplasm and in U2-ribonucleoprotein structures .","gene":["160 kDa nuclear 'domain rich in serines' ( DRS ) protein","U2-ribonucleoprotein structures","MEMA protein"],"gene_indices_start":[36,69,167],"gene_indices_end":[48,125,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":670,"text":"The central globular domain is highly similar to those regions from other H1 molecules , and the carboxyl-terminal domain contains a repeating hexapeptide motif , variants of which are conserved among H1 molecules .","gene":["H1 molecules","H1 molecules"],"gene_indices_start":[74,201],"gene_indices_end":[86,213],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":673,"text":"No evidence for the presence of introns within the acvA gene has been found .","gene":["acvA gene"],"gene_indices_start":[51],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":675,"text":"Weak promoter activity was observed for the promoter of the C1 and C2 ORFs ( C1-C2 gene ) and for the promoter of the V1 ORF .","gene":["C1-C2 gene","V1 ORF","C1 and C2 ORFs"],"gene_indices_start":[60,77,118],"gene_indices_end":[74,87,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":676,"text":"These results strongly suggested that similar , if not identical , the CArG box binding proteins interact with the functionally different promoter element in the VLC1 , cardiac alpha-actin , and c-fos genes .","gene":["c-fos genes","VLC1","cardiac alpha-actin","CArG box binding proteins"],"gene_indices_start":[71,162,169,195],"gene_indices_end":[96,166,188,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":677,"text":"The ORFII gene product is targeted to the chloroplast , which is consistent with previous data indicating the presence of PMSR activity in the chloroplast .","gene":["PMSR","ORFII gene product"],"gene_indices_start":[4,122],"gene_indices_end":[22,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":678,"text":"BACKGROUND : The aim of this study was to determine the response rates and toxicity of two regimens containing granulocyte-macrophage-colony stimulating factor ( GM-CSF ) in combination with interleukin-2 ( IL-2 ) in the treatment of patients with metastatic renal cell carcinoma .","gene":["granulocyte-macrophage-colony stimulating factor","interleukin-2","GM-CSF","IL-2"],"gene_indices_start":[111,162,191,207],"gene_indices_end":[159,168,204,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":682,"text":"The 438 bp EcoRI fragment , which was detected by Southern hybridization , reveals an open reading frame which encodes a protein of 103 amino acids .","gene":["438 bp EcoRI fragment"],"gene_indices_start":[4],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":685,"text":"While this Saccharomyces cerevisiae SIN4 gene product is a component of a mediator complex associated with RNA polymerase II , various studies suggest the involvement of Sin4 in the alteration of higher-order chromatin structure .","gene":["SIN4 gene product","Sin4","RNA polymerase II"],"gene_indices_start":[36,107,170],"gene_indices_end":[53,124,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":686,"text":"A high-resolution restriction map of over 200 kb of contiguous DNA containing N-myc has been generated by subcloning YACs into cosmids .","gene":["N-myc"],"gene_indices_start":[78],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":691,"text":"It thus appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development .","gene":["MAPK"],"gene_indices_start":[21],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":693,"text":"Effect of immune lymphocytes and of rabbit-anti-lymphocyte globulin ( RAMLG ) on infected macrophages exposed to increased incubation temperature in vitro .","gene":["rabbit-anti-lymphocyte globulin","RAMLG"],"gene_indices_start":[36,70],"gene_indices_end":[67,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":699,"text":"The derivatives of the latter two cell lines showed increased expression of the p27Kip1 protein and inhibition of cell growth .","gene":["p27Kip1 protein"],"gene_indices_start":[80],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":700,"text":"Interestingly , the interaction of ZAP-70 with the motif was dependent on the presence of both ZAP-70 SH2 domains and both of the tyrosine residues in the motif , suggesting that ZAP-70 interacts with two phosphotyrosine residues and that the binding of the two SH2 domains is cooperative .","gene":["SH2 domains","ZAP-70","ZAP-70","ZAP-70","SH2 domains"],"gene_indices_start":[35,95,102,179,262],"gene_indices_end":[41,101,113,185,273],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":704,"text":"The conservation of both the G-box and H-box in different CHS promoters emphasizes their importance as regulatory motifs .","gene":["CHS promoters"],"gene_indices_start":[58],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":707,"text":"The LTR-binding activities of VBP , a1 \/ EBP , and B-cell nuclear extract protein were compared and mapped by gel shift , DNase I footprinting , and methylation interference assays .","gene":["VBP","DNase I","a1 \/ EBP"],"gene_indices_start":[30,36,122],"gene_indices_end":[33,44,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":715,"text":"However , overexpression of both the STE4 and STE18 proteins did not generate a stronger pheromone response than overexpression of STE4 in the presence of wild-type levels of STE18 .","gene":["STE18 proteins","STE4","STE4","STE18"],"gene_indices_start":[37,46,131,175],"gene_indices_end":[41,60,135,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":718,"text":"SRC-1 can relieve the NF-kappaB-mediated repression of GR activity .","gene":["SRC-1","GR"],"gene_indices_start":[0,55],"gene_indices_end":[5,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":722,"text":"The chromosomal localization on distal chromosome 7 places it in a cluster of imprinted genes , flanked by the previously described Tapa1 and Kcnq1 genes .","gene":["Kcnq1 genes","Tapa1"],"gene_indices_start":[132,142],"gene_indices_end":[137,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":723,"text":"Consistent with this interpretation , a mutant form of XRN1 , which encodes a 5'-3' exonuclease , was identified as an extragenic suppressor that increases the half-life of rhis4 mRNA , leading to a 10-fold increase in steady-state mRNA levels compared to the wild-type HIS4 mRNA level .","gene":["wild-type HIS4 mRNA","XRN1","rhis4 mRNA"],"gene_indices_start":[55,173,260],"gene_indices_end":[59,183,279],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":725,"text":"Topological and Mutational Analysis of Saccharomyces cerevisiae Ste14p , Founding Member of the Isoprenylcysteine Carboxyl Methyltransferase Family .","gene":["Saccharomyces cerevisiae Ste14p","Isoprenylcysteine Carboxyl Methyltransferase Family"],"gene_indices_start":[39,96],"gene_indices_end":[70,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":726,"text":"The pexB upstream region contained 245 nucleotides within which sequences approximating the consensus for cyclic AMP receptor protein and integration host factor binding sites were discernible .","gene":["integration host factor binding sites","cyclic AMP receptor protein","pexB upstream region"],"gene_indices_start":[4,106,138],"gene_indices_end":[24,133,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":727,"text":"Transient transfections of a construct expressing the RNA transcript defined by clone B1 . 1 into D17 cells led to the expression of an Env \/ Mlvi-4 fusion protein with an apparent molecular mass of 33 kDa .","gene":["Env \/ Mlvi-4 fusion protein"],"gene_indices_start":[136],"gene_indices_end":[163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":729,"text":"While TGF-beta1 does not alter the mitogen-induced expression and abundance of G1 phase cyclin D1 and cdks 4 and 2 in MCs , it inhibits cyclin E-cdk 2 activity , thus preventing mitogen-elicited phosphorylation and inactivation of pRb in G1 phase and transition to S phase .","gene":["cdks 4 and 2","pRb","cyclin D1","cyclin E-cdk 2","TGF-beta1"],"gene_indices_start":[6,88,102,136,231],"gene_indices_end":[15,97,114,150,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":731,"text":"Structural organization and expression of the mouse estrogen receptor .","gene":["mouse estrogen receptor"],"gene_indices_start":[46],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":732,"text":"These data suggest that dopaminergic regulation of adrenal zona glomerulosa corticosteroid and renal renin secretion is absent in patients with high spinal cord transections , suggesting that intact neural pathways from the central nervous system are necessary for metoclopramide stimulation of aldosterone and renin secretion in men .","gene":["renin","renal renin"],"gene_indices_start":[95,311],"gene_indices_end":[106,316],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":735,"text":"Comparison of elastase-1 with amylase , lipase , and trypsin-like immunoreactivity in the diagnosis of acute pancreatitis .","gene":["elastase-1","amylase","lipase"],"gene_indices_start":[14,30,40],"gene_indices_end":[24,37,46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":736,"text":"The Sox gene family ( Sry like HMG box gene ) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding .","gene":["Sox gene family","HMG box gene","Sry"],"gene_indices_start":[4,22,31],"gene_indices_end":[19,25,43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":738,"text":"Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1 .","gene":["pituitary adenylate cyclase-activating polypeptide","Vasoactive intestinal peptide","nuclear factor-kappa B-dependent gene"],"gene_indices_start":[0,34,93],"gene_indices_end":[29,84,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":739,"text":"Homozygous protein C ( PC ) deficiency is reported in two siblings ( girl and boy ) who received their proper diagnoses at the ages of 7 4 \/ 12 and 1 3 \/ 12 years respectively .","gene":["PC","protein C"],"gene_indices_start":[11,23],"gene_indices_end":[20,25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":741,"text":"Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma ( FKHR ) , a recently described member of the hepatocyte nuclear factor 3 \/ forkhead homeotic gene family , as a nuclear hormone receptor ( NR ) intermediary protein .","gene":["NR","hepatocyte nuclear factor 3 \/ forkhead homeotic gene","nuclear hormone receptor","FKHR","forkhead homologue in rhabdomyosarcoma"],"gene_indices_start":[57,98,142,209,236],"gene_indices_end":[95,102,194,233,238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":743,"text":"Cloning of higher plant omega-3 fatty acid desaturases .","gene":["higher plant omega-3 fatty acid desaturases"],"gene_indices_start":[11],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":744,"text":"To determine the true molecular identity of SFD , both the 50- and 57-kDa polypeptides were directly sequenced .","gene":["SFD"],"gene_indices_start":[44],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":746,"text":"In order to decipher the pathway that leads to Hox gene induction , we have investigated whether a Hox gene regulator , the leucine zipper transcription factor MafB \/ Kr , is itself transcriptionally regulated by the environmental signals .","gene":["Hox gene","MafB \/ Kr","Hox gene"],"gene_indices_start":[47,99,160],"gene_indices_end":[55,107,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":750,"text":"The ligand for RXR , 9-cis retinoic acid , has the opposite effect of destabilizing the heterodimeric-DNA complex .","gene":["RXR"],"gene_indices_start":[15],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":751,"text":"The majority of PI kinase activity appeared to be cbl-associated after PRL stimulation .","gene":["PI kinase","PRL"],"gene_indices_start":[16,71],"gene_indices_end":[25,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":753,"text":"Defects of fibrillin ( FBN1 ) , a glycoprotein component of the extracellular microfibril , cause Marfan syndrome .","gene":["fibrillin","FBN1"],"gene_indices_start":[11,23],"gene_indices_end":[20,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":755,"text":"DNA binding and glutathione S-transferase pull-down assays demonstrate that binding requires Elk-1 ( 1-212 ) but not the C-terminal transactivation domain .","gene":["glutathione S-transferase","Elk-1 ( 1-212 )"],"gene_indices_start":[16,93],"gene_indices_end":[41,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":758,"text":"At Cabras ( Oristano ) , a town characterized by a high incidence of thalassaemia and G6PD deficiency less than half the people between 18 and 35 have a fair knowledge of genetic diseases and of their prevention .","gene":["G6PD"],"gene_indices_start":[86],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":759,"text":"These motifs include a Chi motif and a Chi-like element previously found in the recombination hotspot region of the Bcl-2 proto-oncogene and close to chromosomal breakpoints in T-ALL lines .","gene":["Bcl-2 proto-oncogene","Chi motif","Chi-like element"],"gene_indices_start":[23,39,116],"gene_indices_end":[32,55,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":763,"text":"Each recombinant product was a fusion protein with a B domain of Staphylococcal protein A ( SPA ) .","gene":["Staphylococcal protein A","SPA","B domain"],"gene_indices_start":[53,65,92],"gene_indices_end":[61,89,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":764,"text":"The C5 alpha-chain was encoded by 49 kilobases containing 26 exons ; the beta-chain was encoded by 29 kilobases containing 16 exons .","gene":["C5 alpha-chain"],"gene_indices_start":[4],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":767,"text":"In contrast , dig1 dig2 cells constitutively invade agar medium , whereas a dig1 dig2 ste12 triple mutant does not , indicating that Dig1 and Dig2 share a role in negatively regulating the invasive growth pathway .","gene":["Dig2","Dig1","ste12","dig2","dig1","dig2","dig1"],"gene_indices_start":[14,19,76,81,86,133,142],"gene_indices_end":[18,23,80,85,91,137,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":770,"text":"Considerably high levels of IgE antibodies was also established while other pollens did not show such correspondence .","gene":["IgE antibodies"],"gene_indices_start":[28],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":772,"text":"Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblast cell line , as well as TNF-resistant osteosarcoma cell line , U2OS .","gene":["sentrin","DAP-1"],"gene_indices_start":[25,34],"gene_indices_end":[30,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":773,"text":"An association between hSIE and Stat-3 after MHC-I ligation was directly demonstrated by precipitating Stat-3 from nuclear extracts with biotinylated hSIE probe and avidin-coupled agarose .","gene":["Stat-3","Stat-3","hSIE","MHC-I","hSIE"],"gene_indices_start":[23,32,45,103,150],"gene_indices_end":[27,38,50,109,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":775,"text":"We have isolated cDNA clones from rat brain and human liver encoding a putative isoform of the Na , K-ATPase beta subunit .","gene":["Na , K-ATPase beta subunit"],"gene_indices_start":[95],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":776,"text":"Src activation induced by FGF1 was blocked by the SH2 domain of Src and PP2 , a specific inhibitor of Src .","gene":["FGF1","PP2","Src","SH2 domain","Src","Src"],"gene_indices_start":[0,26,50,64,72,102],"gene_indices_end":[3,30,60,67,75,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":780,"text":"However , although deletion of Fp1 in the hCRBP1 gene yielded increased CAT activity , pointing toward a negative regulatory function exerted by this element , its insertion upstream of the p12 basal promoter results in an impressive positive stimulation of CAT gene expression .","gene":["CAT","p12 basal promoter","hCRBP1 gene","Fp1","CAT gene"],"gene_indices_start":[31,42,72,190,258],"gene_indices_end":[34,53,75,208,266],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":781,"text":"Mutational analyses have demonstrated the importance of sequences within the 327 bp segment that contain a putative cyclic AMP responsive element binding protein ( CREB ) binding site for TGF-beta 1 and PMA responsiveness and putative PU-1 and Sp1 binding sites for basal promoter activity .","gene":["cyclic AMP responsive element binding protein","CREB","Sp1 binding sites","PU-1","TGF-beta 1"],"gene_indices_start":[116,164,188,235,244],"gene_indices_end":[161,168,198,239,261],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":783,"text":"Thus , Xlim-1 not only contains a unique tyrosine-rich activation domain but also contains a negative regulatory domain in CT239-403 , suggesting a complex regulatory mechanism underlying the transcriptional activity of Xlim-1 in the organizer .","gene":["CT239-403","Xlim-1","Xlim-1"],"gene_indices_start":[7,123,220],"gene_indices_end":[13,132,226],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":784,"text":"The predicted amino acid sequence exhibited 70% identity to that of Bacillus stearothermophilus TyrTS and 55% identity to that of E . coli TyrTS , while identity to a second cryptic B . subtilis TyrTS gene , designated tyrZ , was only 27% .","gene":["B . subtilis TyrTS gene","Bacillus stearothermophilus TyrTS","E . coli TyrTS","tyrZ"],"gene_indices_start":[68,130,182,219],"gene_indices_end":[101,144,205,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":786,"text":"Sequence conservation is greatest for residues located near the active centers of the exo and pol domains of the E . coli DNA polymerase I structure .","gene":["pol domains","E . coli DNA polymerase I","exo"],"gene_indices_start":[86,94,113],"gene_indices_end":[89,105,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":790,"text":"Although the gene is substantially smaller than the human genes for other mitochondrial enzymes , its intron \/ exon organization is very similar , especially to that of P450scc .","gene":["P450scc"],"gene_indices_start":[169],"gene_indices_end":[176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":791,"text":"This and previous results suggest that the CRE and Sp1 site may synergistically activate TH transcription in a promoter context-dependent manner .","gene":["TH","CRE","Sp1 site"],"gene_indices_start":[43,51,89],"gene_indices_end":[46,59,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":794,"text":"We have previously shown that LBP-1 represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA box .","gene":["LBP-1","TFIID"],"gene_indices_start":[30,95],"gene_indices_end":[35,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":796,"text":"Hex is expressed in the developing liver coincident with the forkhead \/ winged helix transcription factor , Hepatocyte Nuclear Factor 3beta ( HNF3beta ) .","gene":["Hepatocyte Nuclear Factor 3beta","forkhead","winged helix","HNF3beta","Hex"],"gene_indices_start":[0,61,72,108,142],"gene_indices_end":[3,69,84,139,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":797,"text":"The SEN1 gene corresponds to a 6 , 336-bp open reading frame coding for a 2 , 112-amino-acid protein ( molecular mass , 239 kDa ) .","gene":["SEN1 gene"],"gene_indices_start":[4],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":798,"text":"In contrast , transcription initiating from opuE P-1 ( sigma A ) rose in proportion to the external osmolarity and was maintained at high levels .","gene":["opuE P-1","sigma A"],"gene_indices_start":[44,55],"gene_indices_end":[52,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":799,"text":"A synthetic oligonucleotide containing the SRE sequence from the mouse c-fos gene promoter ( -299 to -322 ) was radioactively labeled , used as a probe for the mobility shift assay and Southwestern ( DNA-protein ) blotting , and also used for sequence-specific affinity chromatography .","gene":["mouse c-fos gene promoter","SRE sequence"],"gene_indices_start":[43,65],"gene_indices_end":[55,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":800,"text":"As extensively examined with the myogenin promoter , presence of one or multiple copies of Me in the vectors elevated the expression activity in myotubes by 4 . 5- to 19-fold over those without Me , but not significantly in myoblasts .","gene":["myogenin promoter","Me","Me"],"gene_indices_start":[33,91,194],"gene_indices_end":[50,93,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":802,"text":"Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis .","gene":["Spo0A sporulation transcription factor of Bacillus subtilis"],"gene_indices_start":[48],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":803,"text":"Cytosolic acetyl-CoA synthetase ( AceCS1 ) activates acetate to supply the cells with acetyl-CoA for lipid synthesis .","gene":["Cytosolic acetyl-CoA synthetase","AceCS1"],"gene_indices_start":[0,34],"gene_indices_end":[31,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":806,"text":"Although previous data have suggested that Rev uses the same export pathway as uracil-rich small nuclear RNAs and 5S ribosomal RNA , the CTE seems to interact with evolutionarily conserved factors that are essential for cellular mRNA export .","gene":["5S ribosomal RNA","uracil-rich small nuclear RNAs","Rev","CTE"],"gene_indices_start":[43,79,114,137],"gene_indices_end":[46,109,130,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":807,"text":"These exons were identified by cloning and sequencing cDNAs obtained by polymerase chain reaction amplification of a fibroblast cDNA library .","gene":["polymerase"],"gene_indices_start":[72],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":811,"text":"TMBr-1 is identical to striated muscle alpha-tropomyosin from amino acids 1 through 258 but contains a novel COOH-terminal region from amino acids 259 through 281 .","gene":["TMBr-1","striated muscle alpha-tropomyosin"],"gene_indices_start":[0,23],"gene_indices_end":[6,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":812,"text":"Most of the prepeptide portion of the precursor polypeptide is encoded by the next three exons , and the mature form of IL-1 alpha is encoded by the remaining three exons .","gene":["IL-1 alpha"],"gene_indices_start":[120],"gene_indices_end":[130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":816,"text":"Pargyline , a monoamine oxidase inhibitor , reduces peak 3 transiently ( max .","gene":["monoamine oxidase"],"gene_indices_start":[14],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":817,"text":"The stoichiometry of the complexes formed with the dodeca-satellite C strand suggests that , in DDP1 , the 15 consecutive KH domains are organized such that they define two nucleic acid binding surfaces .","gene":["KH domains","DDP1","dodeca-satellite C strand"],"gene_indices_start":[51,96,122],"gene_indices_end":[76,100,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":819,"text":"Overexpression of BAG-1 also protected certain cell lines from heat shock-induced cell death .","gene":["BAG-1"],"gene_indices_start":[18],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":820,"text":"Thus , VDR acts selectively on the two components required for activation of this promoter \/ enhancer : it competes with NFAT1 for binding to the composite site , positioning itself adjacent to Jun-Fos on the DNA .","gene":["NFAT1","Jun-Fos","VDR"],"gene_indices_start":[7,121,194],"gene_indices_end":[10,126,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":821,"text":"The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades : MSK1 as a potential histone H3 \/ HMG-14 kinase .","gene":["MAP kinase cascades","immediate-early gene","MSK1","histone H3 \/ HMG-14 kinase"],"gene_indices_start":[41,100,122,142],"gene_indices_end":[61,119,126,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":823,"text":"Its organization and regulation indicate that the S . pombe URA1 gene product appears very similar to the S . cerevisiae URA2 gene product .","gene":["S . pombe URA1 gene product","S . cerevisiae URA2 gene product"],"gene_indices_start":[50,106],"gene_indices_end":[77,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":824,"text":"Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9- or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy , respectively .","gene":["apn1","ETH1","ETH1","apn1"],"gene_indices_start":[15,23],"gene_indices_end":[15,19,23,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":825,"text":"The MCAD nuclear receptor response element 1 ( NRRE-1 ) interacts in vitro with ERR alpha expressed in COS-7 cells .","gene":["ERR alpha","NRRE-1","MCAD nuclear receptor response element 1"],"gene_indices_start":[4,47,80],"gene_indices_end":[44,53,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":827,"text":"Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants .","gene":["Gcn4","Gcn4","srb10 mutants","Srb10"],"gene_indices_start":[0,38,98,121],"gene_indices_end":[5,42,102,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":831,"text":"DNA sequence analysis revealed that these clones encode two distinct forms of translocase .","gene":["translocase"],"gene_indices_start":[78],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":832,"text":"Protamine and heparin doses , their sum ( Sigma-dose ) and differential ( Delta-dose ) doses , and activated clotting times were tabulated .","gene":["Protamine"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":833,"text":"In addition , we found that cell-specific suppression of RA-stimulated zif268 gene expression can be attributed to a 29 base pair nucleotide sequence , located downstream of the RA-responsive region in the zif268 gene .","gene":["zif268 gene","RA-responsive region","zif268 gene"],"gene_indices_start":[71,178,206],"gene_indices_end":[82,198,217],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":834,"text":"This structure of cucumisin suggests that it is probably synthesized as an inactive precursor .","gene":["cucumisin"],"gene_indices_start":[18],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":836,"text":"In the current model , Wingless \/ Wnt signal stabilizes Armadillo \/ beta-catenin , which then accumulates in nuclei and binds TCF \/ LEF family proteins , forming bipartite transcription factors which activate transcription of Wingless \/ Wnt responsive genes .","gene":["Wingless \/ Wnt responsive genes","Wingless \/ Wnt","Armadillo \/ beta-catenin","TCF \/ LEF family proteins"],"gene_indices_start":[23,56,126,226],"gene_indices_end":[37,80,151,257],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":837,"text":"In DNA strand exchange reactions using oligonucleotides , we found that Rec2 exhibited a pairing bias that is opposite that of RecA .","gene":["Rec2","RecA"],"gene_indices_start":[72,127],"gene_indices_end":[76,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":838,"text":"The ability of U6-U57 mutants to influence the fidelity of both branch site and 3' splice site recognition suggests that this nucleotide may participate in the formation of the active site ( s ) of the spliceosome .","gene":["U6-U57 mutants"],"gene_indices_start":[15],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":839,"text":"Endorphins and legal issues .","gene":["Endorphins"],"gene_indices_start":[0],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":840,"text":"Human brain cDNA library screening and 5' rapid amplification of cDNA ends yielded full-length DENTT cDNA containing an 1899-bp open reading frame encoding a predicted 633-amino-acid protein with four potential nuclear localization signals ( NLSs ) and two coiled-coil regions .","gene":["full-length DENTT cDNA"],"gene_indices_start":[83],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":842,"text":"The carboxyl-terminal portion of UKLF contains three zinc fingers of the Cys2-His2 type and binds in vitro to the CACCC motif of the beta-globin promoter and to the Sp1 recognition sequence .","gene":["UKLF","beta-globin promoter","Sp1 recognition sequence","CACCC motif"],"gene_indices_start":[33,114,133,165],"gene_indices_end":[37,125,153,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":843,"text":"Since myoglobin is co-extracted with the hemoglobin , the 2 heme pigments are separated in one portion of the extract by precipitating the hemoglobin in an 85% ( NH4 ) 2SO4 solution .","gene":["hemoglobin","myoglobin","hemoglobin"],"gene_indices_start":[6,41,139],"gene_indices_end":[15,51,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":844,"text":"Cloning and characterization of the murine beta ( 3 ) integrin gene promoter : identification of an interleukin-4 responsive element and regulation by STAT-6 .","gene":["murine beta ( 3 ) integrin gene","interleukin-4 responsive element","STAT-6"],"gene_indices_start":[36,100,151],"gene_indices_end":[67,132,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":845,"text":"Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase ( human meprin ) alpha and beta subunits in Madin-Darby canine kidney cells .","gene":["N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase","human meprin"],"gene_indices_start":[41,93],"gene_indices_end":[90,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":846,"text":"ME1a1 , a 16-base-pair nuclear factor binding site residing between the c-MYC P1 and P2 transcription initiation sites , is required for P2 activity .","gene":["ME1a1","P2","c-MYC P1 and P2 transcription initiation sites"],"gene_indices_start":[0,72,137],"gene_indices_end":[5,118,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":847,"text":"Protein tyrosine kinases ( PTKs ) are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes , as intracellular signal transducers , and as growth factor receptors or components thereof .","gene":["growth factor receptors","PTKs","Protein tyrosine kinases"],"gene_indices_start":[0,27,201],"gene_indices_end":[24,31,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":848,"text":"Experiments with epitope-tagged proteins show that UEV1A is a nuclear protein , whereas both Kua and Kua-UEV localize to cytoplasmic structures , indicating that the Kua domain determines the cytoplasmic localization of Kua-UEV .","gene":["UEV1A","Kua","Kua domain","Kua-UEV","Kua-UEV"],"gene_indices_start":[51,93,101,166,220],"gene_indices_end":[56,96,108,176,227],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":855,"text":"By DNase I footprint analysis of the PNR element , a palindrome of two high-affinity Ets-binding sites ( CTTCCCTGGAAG ) was identified .","gene":["DNase I","PNR element","Ets-binding sites","CTTCCCTGGAAG"],"gene_indices_start":[3,37,85,105],"gene_indices_end":[10,48,102,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":856,"text":"Toxicity during the therapeutic period was not significant in the study group compared with the historical control , treated with the same regimen without G-CSF .","gene":["G-CSF"],"gene_indices_start":[155],"gene_indices_end":[160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":857,"text":"Transcripts from a second POU-domain gene , Oct-25 , were present at low levels in oocytes and early embryos and were dramatically upregulated during early gastrulation .","gene":["POU-domain gene","Oct-25"],"gene_indices_start":[26,44],"gene_indices_end":[41,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":860,"text":"The functional mature domain of pediocin AcH ( Lys+1 to Cys+44 ) is targeted into the E . coli sec machinery and secreted to the periplasm in active form when fused in frame to the COOH terminus of the secretory protein maltose-binding protein ( MBP ) .","gene":["MBP","secretory protein maltose-binding protein","pediocin AcH ( Lys+1 to Cys+44 )"],"gene_indices_start":[32,202,246],"gene_indices_end":[64,243,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":861,"text":"In yeast , the products of the UPF1 and UPF3 genes are required for this decay pathway , and in this report we focus on the identification and characterization of additional factors required for rapid decay of nonsense-containing mRNAs .","gene":["UPF1","UPF3 genes"],"gene_indices_start":[31,40],"gene_indices_end":[35,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":863,"text":"Furthermore , microinjection of dominant negative forms of Rac and Cdc42 or of the Rho inhibitor C3 transferase blocked serum-induced DNA synthesis .","gene":["Rho","C3 transferase","Cdc42","Rac"],"gene_indices_start":[59,67,83,97],"gene_indices_end":[62,72,86,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":869,"text":"Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma .","gene":["p53 mutations","Ki-ras"],"gene_indices_start":[0,11],"gene_indices_end":[6,24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":873,"text":"Based on sequence homology , the genes were identified as TEF , encoding translation elongation factor-1 alpha and RPS7 , encoding ribosomal protein S7 .","gene":["RPS7","TEF","ribosomal protein","translation elongation factor-1 alpha","S7"],"gene_indices_start":[58,73,115,131,149],"gene_indices_end":[61,110,119,148,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":875,"text":"As the high-affinity Mg2+ binding sites are filled , the primer terminus migrates from the exonuclease site to a highly based stacked polymerase active site .","gene":["exonuclease site","polymerase active site"],"gene_indices_start":[91,134],"gene_indices_end":[107,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":878,"text":"This strategy was used to place both the Tn903 neo gene and the Rhodosporidium toruloides phenylalanine ammonia lyase ( PAL ) -encoding gene under the transcriptional control of pPGK : : REP2 .","gene":["REP2","PAL","pPGK","Tn903 neo gene","Rhodosporidium toruloides phenylalanine ammonia lyase"],"gene_indices_start":[41,64,120,178,187],"gene_indices_end":[55,117,123,182,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":882,"text":"These same regions showed remarkable homology to two invertebrate proteins , CNC and skin-1 , postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans , respectively .","gene":["CNC","skin-1"],"gene_indices_start":[77,85],"gene_indices_end":[80,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":884,"text":"The other element bound RBP-J kappa with low affinity .","gene":["RBP-J kappa"],"gene_indices_start":[24],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":888,"text":"Actins show two different forms of N-terminal processing dependent on their N-terminal sequence .","gene":["Actins"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":889,"text":"Ex vivo MAO inhibition data indicated DPGPEA to be an inhibitor of MAO-B , although the effect was much weaker than seen with tranylcypromine or pargyline .","gene":["MAO-B","MAO"],"gene_indices_start":[8,67],"gene_indices_end":[11,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":894,"text":"Because of this latter phenomenon , we were able to identify a particular cysteine motif that was repeated multiple times in Dfurin2 but present only twice in mammalian furin .","gene":["Dfurin2","mammalian furin"],"gene_indices_start":[125,159],"gene_indices_end":[132,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":896,"text":"The human purH cDNA is 1776 base pairs in length encoding for a 591-amino acid polypeptic ( Mr = 64 , 425 ) .","gene":["human purH cDNA"],"gene_indices_start":[4],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":901,"text":"Remarkably , U21 contains a long stretch ( 13 nt . ) of complementarity to a highly conserved sequence in 28S rRNA .","gene":["28S rRNA","U21"],"gene_indices_start":[13,106],"gene_indices_end":[16,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":904,"text":"Whereas creatine kinase activity declined exponentially from a single peak , myoglobin appeared in multiple episodes inadequately represented by a single peak value and having no clear clinical correlation .","gene":["myoglobin","creatine kinase"],"gene_indices_start":[8,77],"gene_indices_end":[23,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":905,"text":"Twelve genomic fragments containing novel response elements are described , and the transcription unit associated with one of them , NN-84AG , was characterized in detail .","gene":["NN-84AG"],"gene_indices_start":[133],"gene_indices_end":[140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":906,"text":"Analysis of the consensus binding sequence and the DNA-binding domain of ZF5 .","gene":["ZF5"],"gene_indices_start":[73],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":907,"text":"Sequencing of the TP53 transcripts from exons 2 to 10 , however , did not reveal mutations of the remaining allele in any of these tumors .","gene":["TP53 transcripts"],"gene_indices_start":[18],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":911,"text":"These losses account for the resistance of EDS-IV collagen to cyanogen bromide and mammalian collagenase digestion .","gene":["collagen","mammalian collagenase"],"gene_indices_start":[50,83],"gene_indices_end":[58,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":913,"text":"Expression of p130 ( Cas ) ( Cas ) , a major binding protein for the Crk SH2-domain , also induced JNK activation , which was blocked by the SH2-mutant of Crk .","gene":["JNK","p130 ( Cas )","Crk","Cas","SH2-domain","SH2-mutant","Crk"],"gene_indices_start":[14,29,69,73,99,141,155],"gene_indices_end":[26,32,72,83,102,151,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":914,"text":"Skeletal muscle metaboreceptor responses are impaired in heart failure .","gene":["Skeletal muscle metaboreceptor"],"gene_indices_start":[0],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":915,"text":"The purified recombinant protein was assayed for its enzyme activity by monitoring transfer of [ 3H ] methyl groups from the substrate DNA to the MGMT protein ; the activity was found to be stable at 90 degrees C for at least 30 min .","gene":["MGMT protein"],"gene_indices_start":[146],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":916,"text":"This interaction involved the SH3 region of p50 ( csk ) and a proline-rich region ( PPPLPERTPESFVLADM ) outside the catalytic region of PTP-PEST .","gene":["PTP-PEST","p50 ( csk )","SH3 region","PPPLPERTPESFVLADM"],"gene_indices_start":[30,44,84,136],"gene_indices_end":[40,55,101,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":919,"text":"Data from in vitro splicing assays , UV crosslinking and RNA-binding competition experiments indicates a strong correlation between the binding affinities of PSI for the SELEX sequences and their ability to modulate splicing of P element IVS3 in vitro .","gene":["P element IVS3","PSI"],"gene_indices_start":[158,228],"gene_indices_end":[161,242],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":922,"text":"If hnRNP K is a transcription factor , then interactions with the RNA polymerase II transcription apparatus are predicted .","gene":["RNA polymerase II","hnRNP K"],"gene_indices_start":[3,66],"gene_indices_end":[10,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":923,"text":"Methyl formate was used as the solvent of biodegradable oligoesters for the fabrication of microspheres with encapsulated bovine serum albumin ( BSA ) .","gene":["BSA","bovine serum albumin"],"gene_indices_start":[122,145],"gene_indices_end":[142,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":924,"text":"We report here that constitutively active Mek1 could activate p96h2bk in the absence of oncogenic Ras .","gene":["p96h2bk","Mek1","oncogenic Ras"],"gene_indices_start":[42,62,88],"gene_indices_end":[46,69,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":925,"text":"Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes .","gene":["Botulinum toxin A"],"gene_indices_start":[0],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":926,"text":"Mutational analysis of the P2-proximal CTCF binding site and transient-cotransfection experiments demonstrate that CTCF is a transcriptional repressor of the human c-myc gene .","gene":["CTCF","human c-myc gene","P2-proximal CTCF binding site"],"gene_indices_start":[27,115,158],"gene_indices_end":[56,119,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":928,"text":"Antibodies raised against a bacterially produced beta gal-trk receptor kinase fusion protein recognized a 44 kd phosphoprotein phosphorylated on serine , threonine and tyrosine in extracts of trk-2h transformed NIH3T3 cells .","gene":["beta gal-trk receptor kinase fusion protein","trk-2h"],"gene_indices_start":[49,192],"gene_indices_end":[92,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":931,"text":"Thus , although p28 may play only a limited role during the early embryonic cleavages , it may function later in development to establish a somatic type of cell cycle .","gene":["p28"],"gene_indices_start":[16],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":933,"text":"These indications of deregulated signalling in the absence of tyrosine 118 were substantiated by sustained activation of STAT3 .","gene":["STAT3"],"gene_indices_start":[121],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":934,"text":"Interestingly , this mutant cell line lacks expression of the IKK regulatory protein , IKKgamma .","gene":["IKKgamma","IKK regulatory protein"],"gene_indices_start":[62,87],"gene_indices_end":[84,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":935,"text":"Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form .","gene":["tyrosine kinase","c-kit","Steel factor"],"gene_indices_start":[15,52,103],"gene_indices_end":[27,67,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":936,"text":"Replacement variant histone genes contain intervening sequences .","gene":["Replacement variant histone genes"],"gene_indices_start":[0],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":937,"text":"Transcriptional regulation of the GluR2 gene : neural-specific expression , multiple promoters , and regulatory elements .","gene":["GluR2 gene"],"gene_indices_start":[34],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":940,"text":"To determine whether interaction of arsenite with the hormone-binding domain results in receptor activation , COS-1 cells were transiently cotransfected with the chimeric receptors GAL-ER , which contains the hormone-binding domain of ERalpha and the DNA-binding domain of the transcription factor GAL4 , and a GAL4-responsive CAT reporter gene .","gene":["ERalpha","chimeric receptors GAL-ER","CAT reporter gene","GAL4"],"gene_indices_start":[162,235,298,327],"gene_indices_end":[187,242,302,344],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":944,"text":"The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface-exposed alpha-helical structures .","gene":["RPB5"],"gene_indices_start":[37],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":947,"text":"Each expressed domain , as well as FKBP-33 itself , possesses peptidyl-prolyl cis-trans isomerase activity , though with much lower specific activities than FKBP-12 .","gene":["FKBP-33","FKBP-12","peptidyl-prolyl cis-trans isomerase"],"gene_indices_start":[35,62,157],"gene_indices_end":[42,97,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":949,"text":"The induction of RNKP-1 expression in the Con A-cultured spleen cells is accompanied by increases in both NK and lymphokine-activated killer lymphocyte activities .","gene":["RNKP-1"],"gene_indices_start":[17],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":951,"text":"Sterile mutants of Saccharomyces cerevisiae were isolated from alpha * cells having the a \/ alpha aar1-6 genotype ( exhibiting alpha mating ability and weak a mating ability as a result of a defect in a1-alpha 2 repression ) .","gene":["a1-alpha 2","a \/ alpha aar1-6"],"gene_indices_start":[88,201],"gene_indices_end":[104,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":953,"text":"We report here that out of the major pro-inflammatory cytokines examined , IL-1alpha , IL-1beta , TNF-alpha and IL-6 , only IL-6 was generated and secreted in PKCeta -expressing cells without any additional inducer in serum-supplemented cultures ( 10% FCS ) .","gene":["IL-1beta","IL-6","IL-1alpha","TNF-alpha","IL-6"],"gene_indices_start":[75,87,98,112,124],"gene_indices_end":[84,95,107,116,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":957,"text":"DAF16 is known to be a component of a signaling pathway that has been partially dissected genetically and includes homologues of the insulin \/ IGF-1 receptor , PtdIns 3-kinase and PKB .","gene":["DAF16","PtdIns 3-kinase","insulin \/ IGF-1 receptor","PKB"],"gene_indices_start":[0,133,160,180],"gene_indices_end":[5,157,175,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":960,"text":"Molecular analysis of a novel schizosaccharomyces pombe gene containing two RNP consensus-sequence RNA-binding domains .","gene":["RNP consensus-sequence RNA-binding domains"],"gene_indices_start":[76],"gene_indices_end":[118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":961,"text":"Interestingly , a decreased transcription from the endogenous c-Myb promoter was observed in several HTLV-I transformed T-cell lines .","gene":["c-Myb promoter"],"gene_indices_start":[62],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":963,"text":"The tumor-suppressor protein p53 is involved in maintaining genomic stability .","gene":["tumor-suppressor protein p53"],"gene_indices_start":[4],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":965,"text":"Previous experimental evidence had indicated that Reg1 might target Glc7 to nuclear substrates such as the Snf1 kinase complex .","gene":["Glc7","Reg1","Snf1 kinase complex"],"gene_indices_start":[50,68,107],"gene_indices_end":[54,72,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":969,"text":"Specific class I and II histone deacetylases ( HDACs ) interact in vivo with BCoR , suggesting that BCoR may functionally link these two classes of HDACs .","gene":["BCoR","HDACs","HDACs","class I and II histone deacetylases","BCoR"],"gene_indices_start":[9,47,77,100,148],"gene_indices_end":[44,52,81,104,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":971,"text":"Using varying conditions , three distinct complexes were shown to interact specifically with the NIP region , although only one correlates with repressor activity .","gene":["NIP region"],"gene_indices_start":[97],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":973,"text":"Although the OC promoter is activated in a C terminus dependent manner , the MDR , LTR and BSP promoters are repressed by three distinct mechanisms , either independent of or involving the AML C terminus , or requiring only the conserved C-terminal pentapeptide VWRPY .","gene":["BSP promoters","C-terminal pentapeptide VWRPY","MDR","AML C terminus","OC promoter"],"gene_indices_start":[13,77,91,189,238],"gene_indices_end":[24,80,104,203,267],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":976,"text":"These results indicate that the cis-regulatory elements required for developmental control of the HaG3-A helianthinin gene are located in a 2 . 4 kb upstream region of this gene .","gene":["HaG3-A helianthinin gene"],"gene_indices_start":[98],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":977,"text":"Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter .","gene":["yeast PHO8 promoter","PHO5 promoter"],"gene_indices_start":[34,87],"gene_indices_end":[53,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":979,"text":"Substrates include the p21 ( ras ) proteins , nuclear lamins , and a series of retinal proteins .","gene":["nuclear lamins","p21 ( ras ) proteins"],"gene_indices_start":[23,46],"gene_indices_end":[43,60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":980,"text":"Transcription of the metH gene in Salmonella typhimurium and Escherichia coli is positively regulated by the metR gene product , a DNA binding protein .","gene":["metH gene in Salmonella typhimurium and Escherichia coli","metR gene product"],"gene_indices_start":[21,109],"gene_indices_end":[77,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":982,"text":"Approximately 20% of ALCLs that express ALK do not contain the t ( 2 ; 5 ) , suggesting that other genetic abnormalities can result in aberrant ALK expression .","gene":["ALK","ALK"],"gene_indices_start":[40,144],"gene_indices_end":[43,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":983,"text":"Furthermore , loss of methylation also greatly reduced the association of another yeast B-type subunit , Rts1p .","gene":["Rts1p","yeast B-type subunit"],"gene_indices_start":[82,105],"gene_indices_end":[102,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":984,"text":"Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene , MDR1 \/ P-glycoprotein , in drug-selected cell lines and patients with drug refractory ALL .","gene":["MDR1 \/ P-glycoprotein"],"gene_indices_start":[118],"gene_indices_end":[139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":986,"text":"These genetic alterations do not affect synthesis of the major c-myc protein , p64 , which is initiated from the first AUG codon in exon 2 .","gene":["c-myc protein","p64"],"gene_indices_start":[63,79],"gene_indices_end":[76,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":990,"text":"Treatment with heparin , plasminogen activators and fibrinogenolytic agents was disappointing although renal function has stabilized in one patient on long term oral anticoagulant therapy .","gene":["plasminogen"],"gene_indices_start":[25],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":992,"text":"There was a weak significant correlation between TGF beta 1 levels and normal cell radiosensitivity ( lymphocyte SF2 ) .","gene":["TGF beta 1"],"gene_indices_start":[49],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":993,"text":"We now provide evidence for physical and functional interaction between Doa4 and the proteasome .","gene":["Doa4"],"gene_indices_start":[72],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":994,"text":"We describe a genetic system for further characterizing the role of the extreme C-terminus of the beta subunit of E . coli RNA polymerase .","gene":["E . coli RNA polymerase"],"gene_indices_start":[114],"gene_indices_end":[137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":995,"text":"The single site of glycosylation is located near the C-terminus in the N-glycosylation sequon -Asn-Cys-Ser- in which Cys forms part of a disulphide bridge .","gene":["N-glycosylation sequon -Asn-Cys-Ser-"],"gene_indices_start":[71],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":998,"text":"When combined with independent activating mutations in the c-abl kinase domain or NH2-terminus , the G128R mutation blocked transformation by the double mutant , suggesting that the G128R mutant was unable to transform cells for trivial reasons .","gene":["c-abl kinase domain","G128R","G128R mutant"],"gene_indices_start":[59,101,182],"gene_indices_end":[78,106,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":999,"text":"The csbA fusion was maximally expressed during early stationary phase in cells grown in Luria broth containing 5% glucose and 0 . 2% glutamine .","gene":["csbA fusion"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1001,"text":"A single protease-resistant structure formed by the entirety of both PDZ repeats 1 and 2 ( PDZ1-2 ) contains the protein 4 . 1-binding site .","gene":["protein 4 . 1-binding site","PDZ repeats 1 and 2","PDZ1-2"],"gene_indices_start":[69,91,113],"gene_indices_end":[88,97,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1004,"text":"The cleavage dipeptides of C1YVV NIa protease are Q ( E ) \/ S ( A , G ) .","gene":["Q ( E ) \/ S ( A , G )","C1YVV NIa protease"],"gene_indices_start":[27,50],"gene_indices_end":[45,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1005,"text":"Using mouse-human somatic hybrids and FISH analysis , the PE-2 gene is localized to human chromosome 19q13 . 2 , a region involved in translocations and deletions in leukemias and several solid tumors , suggesting that this novel ETS factor may play a role in carcinogenesis .","gene":["PE-2 gene","ETS factor"],"gene_indices_start":[58,230],"gene_indices_end":[67,240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1008,"text":"Interestingly , these response elements display dramatically reduced affinity for retinoic acid receptor-retinoid-X receptor heterodimers .","gene":["retinoic acid receptor-retinoid-X receptor heterodimers"],"gene_indices_start":[82],"gene_indices_end":[137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1009,"text":"Mutations within the C terminus of c-fos at serine residues that are phosphorylation targets for growth factors and MAP kinase completely abrogate transactivation and block potentiation by MAP kinase .","gene":["MAP kinase","growth factors","MAP kinase","c-fos"],"gene_indices_start":[35,97,116,189],"gene_indices_end":[40,111,126,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1012,"text":"The characterized Aplysia Afurin2 is a candidate PC that may play an important role in the processing of egg-laying hormone ( ELH ) -related precursors in the secretory cells of the atrial gland .","gene":["egg-laying hormone","ELH","Aplysia Afurin2","PC"],"gene_indices_start":[18,49,105,126],"gene_indices_end":[33,51,123,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1013,"text":"A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis .","gene":["RalGDS","Ras"],"gene_indices_start":[11,30],"gene_indices_end":[17,33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1014,"text":"Analyses of hGMR beta subunit mutants revealed two cytoplasmic regions involved in activation of the c-myc promoter , one is essential and the other is dispensable but enhances the activity .","gene":["hGMR beta subunit mutants","c-myc promoter"],"gene_indices_start":[12,101],"gene_indices_end":[37,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1015,"text":"Previously , we reported that scanthrough translation , where the initiating AUG of a primary open reading frame is bypassed , is most likely to account for the presentation of cryptic epitopes from alternative reading frames within the influenza A PR \/ 8 \/ 34 nucleoprotein gene .","gene":["influenza A PR \/ 8 \/ 34 nucleoprotein gene"],"gene_indices_start":[237],"gene_indices_end":[279],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1017,"text":"We find that BCL-6 POZ domain mutations that disrupt the interaction with N-CoR and SMRT no longer repress transcription .","gene":["POZ domain","SMRT","N-CoR","BCL-6"],"gene_indices_start":[13,19,74,84],"gene_indices_end":[18,29,79,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1019,"text":"Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life .","gene":["CD4"],"gene_indices_start":[99],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1020,"text":"Selective stimulation of central alpha-autoreceptors following treatment with alpha-methyldopa and FLA 136 .","gene":["alpha-autoreceptors"],"gene_indices_start":[33],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1022,"text":"The pre-mRNA splicing factor U2AF ( U2 small nuclear ribonucleoprotein particle [ snRNP ] auxiliary factor ) plays a critical role in 3' splice site selection .","gene":["U2AF","U2 small nuclear ribonucleoprotein particle [ snRNP ] auxiliary factor"],"gene_indices_start":[29,36],"gene_indices_end":[33,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1023,"text":"The Euglena ribosomal protein gene cluster resembles the S-10 ribosomal protein operon of Escherichia coli in gene organization and follows the exact linear order of the analogous genes in the tobacco and liverwort chloroplast genomes .","gene":["Euglena ribosomal protein gene cluster","S-10 ribosomal protein operon of Escherichia coli"],"gene_indices_start":[4,57],"gene_indices_end":[42,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1024,"text":"The linear plasmid pCLU1 from the yeast Kluyveromyces lactis normally replicates in the cytoplasm , with the aid of the helper linear plasmid pGKL2 , using terminal protein ( TP ) as a primer .","gene":["TP","terminal protein"],"gene_indices_start":[156,175],"gene_indices_end":[172,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1026,"text":"This hypothesis is consistent with the occurrence of PEA3 binding sites in the PEA3 promoter and with the ability of PEA3 to transactivate this promoter .","gene":["PEA3 promoter","PEA3 binding sites","PEA3"],"gene_indices_start":[53,79,117],"gene_indices_end":[71,92,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1028,"text":"The sequences showed extensive homologies with squalene synthase genes and enzymes from a number of other organisms and extreme amino acid conservation within the binding and catalytic domains .","gene":["squalene synthase genes"],"gene_indices_start":[47],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1033,"text":"Two distinct Salmonella fimbrins , AgfA and SefA , comprising thin aggregative fimbriae SEF17 and SEF14 , respectively , were each genetically engineered to carry PT3 , an alpha-helical 16-amino acid Leishmania T-cell epitope derived from the metalloprotease gp63 .","gene":["metalloprotease","Salmonella fimbrins","AgfA","SefA","SEF14","SEF17","gp63","PT3"],"gene_indices_start":[13,35,44,88,98,163,243,259],"gene_indices_end":[32,39,48,93,103,166,258,263],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1037,"text":"These data show that the spv virulence genes belong simultaneously to several regulons in the cell , raising the possibility that spv expression can be fine-tuned in response to multiple environmental inputs .","gene":["spv","spv virulence genes"],"gene_indices_start":[25,130],"gene_indices_end":[44,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1038,"text":"Clb2 \/ Cdc28 kinase is not required for the repression of MCB-binding factor transcriptional activity in G2 and M phase .","gene":["Clb2 \/ Cdc28 kinase","MCB-binding factor"],"gene_indices_start":[0,58],"gene_indices_end":[19,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1039,"text":"Cbf3 contains three proteins , Cbf3a , Cbf3b and Cbf3c .","gene":["Cbf3c","Cbf3","Cbf3a","Cbf3b"],"gene_indices_start":[0,31,39,49],"gene_indices_end":[4,36,44,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1045,"text":"Use of serum thyroglobulin determination in the follow-up of differentiated carcinomas of the thyroid .","gene":["thyroglobulin"],"gene_indices_start":[13],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1047,"text":"No such benefits were seen for children with CD4+ counts below 0 . 2 x 10 ( 9 ) per liter at entry .","gene":["CD4+"],"gene_indices_start":[45],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1048,"text":"Pyk2 phosphorylation increased upon adherence of FLG 29 . 1 cells to fibronectin and to ST2 stromal cells .","gene":["Pyk2","fibronectin"],"gene_indices_start":[0,69],"gene_indices_end":[4,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1050,"text":"Mutagenesis of IM1 enhances the ability of c-Fos to activate an AP1 bearing promoter .","gene":["IM1","AP1 bearing promoter","c-Fos"],"gene_indices_start":[15,43,64],"gene_indices_end":[18,48,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1052,"text":"Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats .","gene":["acetyl cholinesterase"],"gene_indices_start":[12],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1053,"text":"The bZP2 cDNA ( 115-1914 nt , 1 . 8 kb ) , excluding sequences coding for N-terminal signal sequence and C-terminal transmembranelike domain , was PCR amplified and Sac1-Sal1 restricted fragment cloned in frame downstream of the T5 promoter under the lac operator control in a pQE-30 vector .","gene":["bZP2 cDNA ( 115-1914 nt , 1 . 8 kb )","Sac1-Sal1 restricted fragment","lac operator"],"gene_indices_start":[4,165,251],"gene_indices_end":[40,194,263],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1056,"text":"A tobacco homologue ( trolC ) of the rolC gene of the Agrobacterium rhizogenes Ri-plasmid was cloned and sequenced from Nicotiana tabacum L . cv .","gene":["rolC gene of the Agrobacterium rhizogenes Ri-plasmid","trolC"],"gene_indices_start":[22,37],"gene_indices_end":[27,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1060,"text":"The expression of the putative operon bglPH of Bacillus subtilis was studied by using bglP'-lacZ transcriptional fusions .","gene":["bglP'-lacZ transcriptional fusions","bglPH"],"gene_indices_start":[38,86],"gene_indices_end":[43,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1063,"text":"Cloning and characterization of human Lnk , an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation .","gene":["human Lnk","pleckstrin","Src homology 2 domains"],"gene_indices_start":[32,68,92],"gene_indices_end":[41,78,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1066,"text":"Disruption of any one of the four genes encoding the newly identified SRP proteins results in slow cell growth and inefficient protein translocation across the ER membrane .","gene":["SRP proteins"],"gene_indices_start":[70],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1068,"text":"An increase in the level of serum enzymes , such as aspartate transaminase , alkaline phosphatase , creatine phosphokinase , lactate dehydrogenase after D . russelli venom injection in albino rats is indicative of cell or tissue damage .","gene":["alkaline phosphatase","aspartate transaminase","creatine phosphokinase","lactate dehydrogenase"],"gene_indices_start":[52,77,100,125],"gene_indices_end":[74,97,122,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1071,"text":"Primer extension and mung bean and S1 nuclease mapping indicated multiple transcription initiation sites and were consistent with Northern analyses .","gene":["mung bean and S1 nuclease"],"gene_indices_start":[21],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1072,"text":"GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae .","gene":["GCN4"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1074,"text":"The cysteine-rich region of raf-1 kinase contains zinc , translocates to liposomes , and is adjacent to a segment that binds GTP-ras .","gene":["GTP-ras","raf-1 kinase"],"gene_indices_start":[28,125],"gene_indices_end":[40,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1075,"text":"The CBF1 site within HS2 resides near sites for hematopoietic regulators such as GATA-1 , NF-E2 , and TAL1 .","gene":["GATA-1","TAL1","NF-E2","CBF1 site","HS2"],"gene_indices_start":[4,21,81,90,102],"gene_indices_end":[13,24,87,95,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1076,"text":"Here we provide the first evidence for the involvement of GCN1-GCN2 interaction in activation of GCN2 per se .","gene":["GCN1-GCN2","GCN2"],"gene_indices_start":[58,97],"gene_indices_end":[67,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1081,"text":"20% of total HSL transcripts in human subcutaneous adipocytes .","gene":["HSL transcripts"],"gene_indices_start":[13],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1082,"text":"Western analyses with antisera raised against Lu-ECAM-1 peptides show that the N-terminal region of the predicted open reading frame is present only in the larger size proteins ( i . e .","gene":["Lu-ECAM-1 peptides"],"gene_indices_start":[46],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1084,"text":"In contrast , the action of GLP-1 at the CRE was not blocked by cotransfection with M1-CREB , an isoform that lacks a consensus serine residue serving as substrate for PKA-mediated phosphorylation .","gene":["M1-CREB","GLP-1","CRE"],"gene_indices_start":[28,41,84],"gene_indices_end":[33,44,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1086,"text":"The cleavage of Fak by caspases may thus play an important role in the execution of the suicide program by disabling the anti-apoptotic function of Fak .","gene":["caspases","Fak","Fak"],"gene_indices_start":[16,23,148],"gene_indices_end":[19,31,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1087,"text":"As authorized by the World Health Organization 29th Expert Committee on Biological Standardization , the preparation of human prolactin in ampoules coded 75 \/ 504 has been established as the International Reference Preparation ( IRP ) of human prolactin for immunoassay .","gene":["human prolactin","human prolactin"],"gene_indices_start":[120,238],"gene_indices_end":[135,253],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1089,"text":"The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110 .","gene":["p110","SH2","pp60src","p130","SH3 domains"],"gene_indices_start":[4,12,27,99,108],"gene_indices_end":[7,23,34,103,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1091,"text":"A particularly striking HpaII tiny fragment island , extending over nearly 2 , 000 base pairs , surrounds the USF2 translation initiation site .","gene":["USF2 translation initiation site","HpaII"],"gene_indices_start":[24,110],"gene_indices_end":[29,142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1092,"text":"Our results implicate TGF-beta RII as a direct target of EWS-FLI1 .","gene":["TGF-beta RII","EWS-FLI1"],"gene_indices_start":[22,57],"gene_indices_end":[34,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1094,"text":"Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1 .","gene":["infected-cell protein 0"],"gene_indices_start":[58],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1095,"text":"Localization of 67 exons on a YAC contig spanning 1 . 5 Mb around the multidrug resistance gene region of human chromosome 7q21 . 1 .","gene":["multidrug resistance gene region"],"gene_indices_start":[70],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1097,"text":"The genes encoding ( 2Fe-2S ) plant-like ferredoxins were studied in the widely used cyanobacterium Synechocystis PCC6803 .","gene":["( 2Fe-2S ) plant-like ferredoxins"],"gene_indices_start":[19],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1099,"text":"Transfer RNA genes from Dictyostelium discoideum are frequently associated with repetitive elements and contain consensus boxes in their 5' and 3'-flanking regions .","gene":["Transfer RNA genes from Dictyostelium discoideum"],"gene_indices_start":[0],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1104,"text":"In addition , C \/ EBP beta and C \/ EBP gamma readily heterodimerize with each other as well as with C \/ EBP alpha .","gene":["C \/ EBP beta","C \/ EBP alpha","C \/ EBP gamma"],"gene_indices_start":[14,31,100],"gene_indices_end":[26,44,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1105,"text":"Intraoperative measurement of activated partial thromboplastin time and prothrombin time with a new compact monitor .","gene":["prothrombin","thromboplastin"],"gene_indices_start":[48,72],"gene_indices_end":[62,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1106,"text":"The pattern of RNase E digestion of finP305 RNA differed from FinP , and GST-FinO did not protect finP305 RNA from cleavage in vitro .","gene":["finP305 RNA","GST-FinO","finP305 RNA","FinP","RNase E"],"gene_indices_start":[15,36,62,73,98],"gene_indices_end":[22,47,66,81,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1108,"text":"Second , the membrane expression of alpha and beta subunits was mimicked by cholesterol and 17-ketocholesterol , both of which inhibit HMG-CoA reductase .","gene":["HMG-CoA reductase"],"gene_indices_start":[135],"gene_indices_end":[152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1109,"text":"In vitro affinity analyses demonstrated that recombinant 130-kD protein directly interacts with ZO-1 and the cytoplasmic domain of occludin , but not with ZO-2 .","gene":["ZO-1","occludin","ZO-2"],"gene_indices_start":[96,131,155],"gene_indices_end":[100,139,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1111,"text":"Next , we stably overexpressed wild-type Shc or Y317F mutant Shc into HIRc cells .","gene":["wild-type Shc","Y317F mutant Shc"],"gene_indices_start":[31,48],"gene_indices_end":[44,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1112,"text":"CONCLUSIONS : A comparison of the LysU crystal structure with the structures of seryl- and aspartyl-tRNA synthetases enables a conserved core to be identified .","gene":["LysU","seryl- and aspartyl-tRNA synthetases"],"gene_indices_start":[34,80],"gene_indices_end":[38,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1115,"text":"Mice homozygous for the dlg mutation exhibit growth retardation in utero , have hypoplasia of the premaxilla and mandible , have a cleft secondary palate , and die perinatally .","gene":["dlg"],"gene_indices_start":[24],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1116,"text":"Here we focused on the role of the 5' proximal regulatory cassette ( -190 ; +53 bp ) of the rat enkephalin ( rENK ) gene in the developmental regulation of the enkephalin phenotype .","gene":["rat enkephalin","rENK","enkephalin"],"gene_indices_start":[92,109,160],"gene_indices_end":[106,113,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1120,"text":"The two genes code for polypeptides of 420 amino acids ( M . HgiCI ) and 345 amino acids ( R . HgiCI ) .","gene":["polypeptides of 420 amino acids ( M . HgiCI )","345 amino acids ( R . HgiCI )"],"gene_indices_start":[23,73],"gene_indices_end":[68,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1121,"text":"Glucose-6-phosphate dehydrogenase ( G-6-PD ) deficiency in the newborn .","gene":["G-6-PD","Glucose-6-phosphate dehydrogenase"],"gene_indices_start":[0,36],"gene_indices_end":[33,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1123,"text":"The two mouse lines carrying the unfragmented Hnf3g-lacZ YAC showed tissue-specific , copy number-dependent and position-independent expression , proving that 170 kb of the Hnf3g locus contain all elements important in the regulation of Hnf3g .","gene":["Hnf3g","Hnf3g-lacZ YAC","Hnf3g"],"gene_indices_start":[46,173,237],"gene_indices_end":[60,178,242],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1125,"text":"Previous work has shown that spleen necrosis virus ( SNV ) long terminal repeats ( LTRs ) are associated with Rex \/ Rex-responsive element-independent expression of bovine leukemia virus RNA and supports the hypothesis that SNV RNA contains a cis-acting element that interacts with cellular Rex-like proteins .","gene":["cellular Rex-like proteins"],"gene_indices_start":[282],"gene_indices_end":[308],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1126,"text":"After successful subtotal parathyroidectomy , evident by the decrease of serum iPTH levels , both the CL of group 2 PMNs and the ability of group 2 sera to induce augmented CL in normal PMNs decreased ( p < 0 . 025 ) .","gene":["iPTH"],"gene_indices_start":[79],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1130,"text":"IgG levels of 1 \/ 100 were present in only four out of ten samples obtained 150 days after the clinical onset .","gene":["IgG"],"gene_indices_start":[0],"gene_indices_end":[3],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1131,"text":"RNase protection and primer extension assays confirmed that the 5' non-coding exon is included in the DDT1 aFGF mRNA and that a major transcription start site is approximately 136 bp upstream of the 5' non-coding splice junction of this exon .","gene":["aFGF mRNA","RNase"],"gene_indices_start":[0,107],"gene_indices_end":[5,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1136,"text":"Eukaryotic initiation factor 3 ( eIF3 ) is a large multisubunit complex that stabilizes the ternary complex , eIF2 x GTP x tRNA ( Met ) i and promotes mRNA binding to the 40 S ribosomal subunit . eIF3 also functions as a ribosome subunit anti-association factor .","gene":["Eukaryotic initiation factor 3","eIF3","eIF2","tRNA ( Met ) i","40 S ribosomal subunit","GTP","eIF3"],"gene_indices_start":[0,33,110,117,123,171,196],"gene_indices_end":[30,37,114,120,137,193,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1137,"text":"To investigate the effects of isotretinoin on HDL , we measured HDL-C , HDL phospholipids ( HDL-PL ) , apoprotein A1 ( apo A-1 ) , and HDL-C subfractions ( HDL2-C and HDL3-C ) in 24 healthy , male patients receiving a 16-week course of isotretinoin ( 1 . 0 mg \/ kg \/ day ) for treatment of severe acne vulgaris .","gene":["HDL3-C","apoprotein A1","HDL-PL","apo A-1","HDL-C","HDL","HDL2-C","HDL-C","HDL"],"gene_indices_start":[46,64,72,92,103,119,135,156,167],"gene_indices_end":[49,69,75,98,116,126,140,162,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1138,"text":"The expression of the pilin gene , tcpA , is dependent upon ToxR and upon ToxT .","gene":["ToxT","ToxR","pilin gene","tcpA"],"gene_indices_start":[22,35,60,74],"gene_indices_end":[32,39,64,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1141,"text":"This GAP activity was observed in 3T3-L1 adipocyte lysates , and was able to accelerate the hydrolysis of the [ alpha-32P ] GTP bound to GST-Rab4 into [ alpha-32P ] GDP .","gene":["GST-Rab4","GAP"],"gene_indices_start":[5,137],"gene_indices_end":[8,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1142,"text":"NF-kappa B \/ Rel transcription factors participate in the activation of numerous genes involved in immune regulation \/ inflammation including cytokines , cell surface receptors , adhesion molecules , and acute phase proteins .","gene":["NF-kappa B \/ Rel transcription factors"],"gene_indices_start":[0],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1144,"text":"The predicted protein , Seb1p , consists of 82 amino acids and contains one potential membrane-spanning region at the C-terminus but no N-terminal signal sequence .","gene":["Seb1p"],"gene_indices_start":[24],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1146,"text":"Northern blot analysis revealed the expression of LIMK-1 mRNA predominantly in the brain and the expression of LIMK-2 mRNA in various tissues in the rat .","gene":["LIMK-2 mRNA","LIMK-1 mRNA"],"gene_indices_start":[50,111],"gene_indices_end":[61,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1147,"text":"Cyclin-dependent kinase-2 ( Cdk2 ) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H .","gene":["Cdk2","cyclin D1","Cdk7-cyclin-H","Cyclin-dependent kinase-2","cyclin D1","Cdk2"],"gene_indices_start":[0,28,66,82,103,138],"gene_indices_end":[25,32,75,86,112,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1153,"text":"In the present report , 66 hemochromatosis families yielding 151 hemochromatosis chromosomes and 182 normal chromosomes were RFLP-typed with a battery of probes , including two newly derived polymorphic markers from the 6 . 7 and HLA-F loci located 150 and 250 kb telomeric to HLA-A , respectively .","gene":["HLA-A","HLA-F loci"],"gene_indices_start":[230,277],"gene_indices_end":[240,282],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1154,"text":"The p34 . 8 gene has a strong codon usage bias which is strikingly different from that of the polyhedrin gene .","gene":["p34 . 8 gene","polyhedrin gene"],"gene_indices_start":[4,94],"gene_indices_end":[16,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1157,"text":"The chloramphenicol-resistance transposon Tn4451 undergoes precise conjugative deletion from its parent plasmid plP401 in Clostridium perfringens and precise spontaneous excision from multicopy plasmids in Escherichia coli .","gene":["Tn4451","chloramphenicol-resistance transposon"],"gene_indices_start":[4,42],"gene_indices_end":[41,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1158,"text":"These temperature- and cold-sensitive strains were used to prepare extracts deficient in BRF1 activity and were tested for transcriptional activity by RNA polymerases I , II , and III in vitro .","gene":["RNA polymerases I , II , and III","BRF1"],"gene_indices_start":[89,151],"gene_indices_end":[93,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1159,"text":"These data are consistent with a model in which GATA-5 performs a unique temporally and spatially restricted function in the embryonic heart and lung .","gene":["GATA-5"],"gene_indices_start":[48],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1161,"text":"The Cili-2 sequences possess similarity to the RNaseH domain of Lian-Aa1 , a mosquito non-LTR retrotransposon .","gene":["RNaseH domain","Cili-2 sequences","Lian-Aa1"],"gene_indices_start":[4,47,64],"gene_indices_end":[20,60,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1164,"text":"Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1 is a major component of mammalian hnRNP 40 S particles .","gene":["mammalian hnRNP 40 S particles","Heterogeneous nuclear ribonucleoprotein ( hnRNP ) core protein A1"],"gene_indices_start":[0,90],"gene_indices_end":[65,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1166,"text":"Yeast U1 snRNP is considerably more complex than its metazoan counterpart , which suggests possible differences between yeast and metazoa in early splicing events .","gene":["Yeast U1 snRNP"],"gene_indices_start":[0],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1167,"text":"Plasma CCK levels were determined at regular intervals .","gene":["CCK"],"gene_indices_start":[7],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1168,"text":"In addition , stonin 2 binds to the C2B domains of synaptotagmins I and II .","gene":["stonin 2","C2B domains","synaptotagmins I and"],"gene_indices_start":[14,36,51],"gene_indices_end":[22,47,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1170,"text":"E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway .","gene":["apolipoprotein AI enhancer","E1A"],"gene_indices_start":[0,14],"gene_indices_end":[3,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1171,"text":"RESULTS : Circulating leptin concentrations in AN were 3 . 5+ \/ -0 . 5 versus 7 . 6+ \/ -1 . 2 ng \/ ml in control subjects .","gene":["leptin"],"gene_indices_start":[22],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1172,"text":"In addition , two internal promoters , PmiaA and P1hfq were identified and mapped to 201 and 837 nucleotides upstream from the respective translation start sites .","gene":["P1hfq","PmiaA"],"gene_indices_start":[39,49],"gene_indices_end":[44,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1181,"text":"The yeast MMS2 gene was cloned by its ability to complement the methyl methanesulfonate sensitivity of the mms2-1 mutant and was later shown to be involved in DNA post-replication repair .","gene":["yeast MMS2 gene","mms2-1 mutant"],"gene_indices_start":[4,107],"gene_indices_end":[19,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1184,"text":"Genes belonging to the ras superfamily encode low-molecular-weight GTP \/ GDP-binding proteins that are highly conserved in wide variety of organisms .","gene":["low-molecular-weight GTP \/ GDP-binding proteins","ras superfamily"],"gene_indices_start":[23,46],"gene_indices_end":[38,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1186,"text":"A cDNA encoding a MYC-related DNA binding protein was isolated by DNA-ligand binding screening , using the 67-bp region as a probe , and designated rd22BP1 .","gene":["MYC-related DNA binding protein","rd22BP1"],"gene_indices_start":[18,148],"gene_indices_end":[49,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1187,"text":"Two phosphopeptides , identified as RS- [ 32P ] SGASGLLTSEHHSR and S- [ 32P ] SGASGLLTSEHHSR , were obtained after stoichiometric phosphorylation and trypsinization of the peptide .","gene":["RS- [ 32P ] SGASGLLTSEHHSR","S- [ 32P ] SGASGLLTSEHHSR"],"gene_indices_start":[36,67],"gene_indices_end":[62,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1190,"text":"Moreover , expression of CBF1 in yeast was found to activate transcription of reporter genes containing the C-repeat \/ DRE as an upstream activator sequence but not mutant versions of the DNA element .","gene":["C-repeat \/ DRE","CBF1"],"gene_indices_start":[25,108],"gene_indices_end":[29,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1192,"text":"Levels of TSG-14 protein ( also termed PTX-3 ) become elevated in the serum of mice and humans after injection with bacterial lipopolysaccharide , but in contrast to conventional acute phase proteins , the bulk of TSG-14 synthesis in the intact organism occurs outside the liver .","gene":["TSG-14","PTX-3","TSG-14 protein"],"gene_indices_start":[10,39,214],"gene_indices_end":[24,44,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1196,"text":"Thus , the characterization of the promoter region should help to define regulatory elements that control neuron-specific and developmental expression of the MAP1B gene .","gene":["MAP1B gene"],"gene_indices_start":[158],"gene_indices_end":[168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1198,"text":"Transfection of non-deleted expression vector into NIH3T3 cells results in acquisition of focus-forming activity while a deleted form of expression vector fails to show this activity even in the presence of basic FGF .","gene":["basic FGF"],"gene_indices_start":[207],"gene_indices_end":[216],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1199,"text":"The results suggest that the bulbospinal micturition reflex evoked by bladder filling and L-dopa involves a descending pathway where transmission is partly mediated by spinal alpha 1-adrenoceptors .","gene":["spinal alpha 1-adrenoceptors"],"gene_indices_start":[168],"gene_indices_end":[196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1200,"text":"Although isl-1 binds to both the insulin and amylin gene promoter elements in vitro , these sequences display marked differences in their relative transcriptional properties when ligated adjacent to a heterologous promoter and transfected into InR1 -G9 islet cells .","gene":["insulin","isl-1","amylin gene promoter elements"],"gene_indices_start":[9,33,45],"gene_indices_end":[14,40,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1202,"text":"Study of antinuclear autoantibodies by immunofluorescence technic in collagen diseases .","gene":["antinuclear autoantibodies","collagen"],"gene_indices_start":[9,69],"gene_indices_end":[35,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1205,"text":"These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes .","gene":["RNK-Met-1","serine protease"],"gene_indices_start":[25,40],"gene_indices_end":[34,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1209,"text":"Together , these results identify HPK1 as a new component of TCR signaling .","gene":["HPK1","TCR"],"gene_indices_start":[34,61],"gene_indices_end":[38,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1211,"text":"The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains .","gene":["pertussis toxin","CC chemokine receptor 5"],"gene_indices_start":[18,46],"gene_indices_end":[33,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1214,"text":"The different holoenzyme RNA polymerases generated upon reconstituting these mutants independently with core RNA polymerase ( alpha2beta beta' ) have shown reduced transcriptional activity in comparison to the enzyme containing wild-type sigma factor .","gene":["alpha2beta beta'","core RNA polymerase","wild-type sigma factor","holoenzyme RNA polymerases"],"gene_indices_start":[14,104,126,228],"gene_indices_end":[40,123,142,250],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1216,"text":"Contacts between Bacillus subtilis catabolite regulatory protein CcpA and amyO target site .","gene":["amyO","CcpA"],"gene_indices_start":[65,74],"gene_indices_end":[69,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1217,"text":"Thus , the tri-snRNP-specific 27K protein could potentially be involved in SR protein-mediated protein \/ protein interactions and , additionally , its phosphorylation state could modulate pre-mRNA splicing .","gene":["tri-snRNP-specific 27K protein","SR"],"gene_indices_start":[11,75],"gene_indices_end":[41,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1218,"text":"Tcn1p \/ Crz1p , a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae .","gene":["Tcn1p \/ Crz1p"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1219,"text":"A comparison of the Flavobacterium glycosylasparaginase with a mammalian glycosylasparaginase revealed 30% structural identity and 60% overall similarity between the prokaryotic and eukaryotic forms of the enzyme .","gene":["glycosylasparaginase","glycosylasparaginase"],"gene_indices_start":[35,73],"gene_indices_end":[55,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1220,"text":"This region , however , contains a CCAATC box in the reverse complement and several GC boxes that are recognition sites for SP1 .","gene":["SP1"],"gene_indices_start":[124],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1221,"text":"Furthermore , the amount of tRNA ( 3Lys ) that was placed onto viral RNA in mutated viruses was significantly less than that placed in the wild-type virus .","gene":["tRNA ( 3Lys )"],"gene_indices_start":[28],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1226,"text":"Evidence for the promoting role of the intra-uterine kinin release in the development of late hypertonic saline-induced abortion .","gene":["intra-uterine kinin"],"gene_indices_start":[39],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1227,"text":"Cross-linking FcalphaR on wt-ITAM or IIA-ITAM cells triggered equivalent PI 3-kinase-dependent activation of PKBalpha .","gene":["IIA-ITAM","PKBalpha","wt-ITAM","FcalphaR"],"gene_indices_start":[14,26,37,109],"gene_indices_end":[22,33,45,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1228,"text":"Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells .","gene":["human alternatively spliced truncated reduced folate carrier"],"gene_indices_start":[22],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1230,"text":"Recently , we discovered that alanine substitutions of the active center cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP .","gene":["PAP"],"gene_indices_start":[162],"gene_indices_end":[165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1236,"text":"The TUP1 gene was isolated in a screen for genes that regulate mating type ( V . L .","gene":["TUP1 gene"],"gene_indices_start":[4],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1237,"text":"The Caenorhabditis elegans death susceptibility gene , ced-3 , has a number of homologs in vertebrate species , including interleukin-1 beta ( IL-1 beta ) -converting enzyme ( ICE ) , Ich-1long , and CPP32 .","gene":["CPP32","interleukin-1 beta ( IL-1 beta ) -converting enzyme","Caenorhabditis elegans death susceptibility gene","ICE","Ich-1long","ced-3"],"gene_indices_start":[4,55,122,176,184,200],"gene_indices_end":[52,60,173,179,193,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1238,"text":"RPS14 introns 3 and 4 both contain Alu sequences .","gene":["RPS14","Alu sequences"],"gene_indices_start":[0,35],"gene_indices_end":[5,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1239,"text":"Transcription factors of the Stat family are controlled by protein kinases .","gene":["protein kinases","Stat family"],"gene_indices_start":[29,59],"gene_indices_end":[40,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1240,"text":"A novel , testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase . mRNA diversity represents a major theme of neuronal nitric-oxide synthase ( nNOS ) gene expression in somatic cells \/ tissues .","gene":["neuronal nitric-oxide synthase","nNOS","NH2-terminal truncated nitric-oxide synthase","testis-specific mRNA transcript"],"gene_indices_start":[10,54,144,177],"gene_indices_end":[41,98,174,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1241,"text":"The isoform , designated HDAC9a , is 132 aa shorter at the C terminus than HDAC9 .","gene":["HDAC9","HDAC9a"],"gene_indices_start":[25,75],"gene_indices_end":[31,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1246,"text":"After gamma-irradiation , the majority of F9 cells undergo apoptosis implying that wt-p53 likely triggers pro-apoptotic gene expression in DNA damaged cells .","gene":["wt-p53"],"gene_indices_start":[83],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1247,"text":"While fusion to the N-terminus required a linker to become surface accessible , both fusion to the N-terminus and to the C-terminus was compatible with particle assembly and preserved the native antigenicity and immunogenicity of HBcAg .","gene":["HBcAg"],"gene_indices_start":[230],"gene_indices_end":[235],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1251,"text":"Isolation by PCR of a cDNA clone from pea petals with similarity to petunia and wheat zinc finger proteins .","gene":["wheat zinc finger proteins"],"gene_indices_start":[80],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1254,"text":"The 227-to-239 region blocked ADR1 activity independently of the TAD present on ADR1 , ADR1 DNA binding , and specific ADH2 promoter sequences .","gene":["ADH2 promoter sequences","ADR1","ADR1","ADR1","TAD"],"gene_indices_start":[30,65,80,87,119],"gene_indices_end":[34,68,84,91,142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1255,"text":"A polypeptide chain of 34 residues of the deduced yeast amino acid sequence closely resembles a peptide sequence at the ADP binding site of bovine muscle pyruvate kinase .","gene":["bovine muscle pyruvate kinase"],"gene_indices_start":[140],"gene_indices_end":[169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1259,"text":"Nuclear hormone receptors ( NRs ) are ligand-inducible transcription factors that mediate critical functions in many species .","gene":["Nuclear hormone receptors","NRs"],"gene_indices_start":[0,28],"gene_indices_end":[25,31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1261,"text":"Ethylene is involved in endosperm rupture and high-level betaGLU I expression ; but , it does not affect the spatial and temporal pattern of betaGLU I expression .","gene":["betaGLU I","betaGLU I"],"gene_indices_start":[57,141],"gene_indices_end":[66,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1264,"text":"The normal cell cycle is regulated by several molecules , such as the tumor-suppressor protein pRb , the G1 cyclins , the cyclin-dependent kinases , and their inhibitors .","gene":["tumor-suppressor protein pRb","G1 cyclins","cyclin-dependent kinases"],"gene_indices_start":[70,105,122],"gene_indices_end":[98,115,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1266,"text":"In this paper , we demonstrate that binding of the GA-binding protein ( GABP ) to ets sequence motifs within each repeated unit is required for transcriptional activation of the COXIV promoter .","gene":["ets sequence motifs","GABP","GA-binding protein","COXIV promoter"],"gene_indices_start":[51,72,82,178],"gene_indices_end":[69,76,101,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1269,"text":"Overall , these findings demonstrate that mutations E768D and V804L are gain-of-function mutations that confer to the long RET isoform the capacity to exert a biological effect , although these mutations are more weakly activating than the MEN2A and MEN2B mutations .","gene":["long RET isoform","MEN2B","MEN2A"],"gene_indices_start":[118,240,250],"gene_indices_end":[134,245,255],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1270,"text":"Several of the exon boundaries correspond to the boundaries of functional domains in the p55 protein .","gene":["p55 protein"],"gene_indices_start":[89],"gene_indices_end":[100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1271,"text":"HS inducibility required the HSE which was bound by HS transcription factor-1 ( HSF-1 ) present in extracts prepared from cells exposed to HS .","gene":["HS transcription factor-1 ( HSF-1 )","HSE"],"gene_indices_start":[29,52],"gene_indices_end":[32,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1273,"text":"The avidin-biotin complex peroxidase ( ABC-P ) method was used to detect Mycobacterium bovis , and the results were compared with those obtained by the Ziehl-Neelsen ( ZN ) technique .","gene":["ABC-P","avidin-biotin complex peroxidase"],"gene_indices_start":[4,39],"gene_indices_end":[36,44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1276,"text":"Both mutant receptors were expressed on the cell surface and bound insulin normally , but showed markedly impaired autophosphorylation in response to insulin .","gene":["insulin","insulin"],"gene_indices_start":[67,150],"gene_indices_end":[74,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1278,"text":"A second , novel C subunit ( CeCAT alpha' , 374 residues ) has a unique 56-residue carboxyl-terminal region that is generated by the alternative splicing of the C pre-mRNA .","gene":["C subunit","CeCAT alpha'","C pre-mRNA"],"gene_indices_start":[17,29,161],"gene_indices_end":[26,41,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1279,"text":"The mouse extracellular signal-regulated kinase 2 gene .","gene":["extracellular signal-regulated kinase 2 gene"],"gene_indices_start":[10],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1280,"text":"Interaction of H-2Eb with an IAP retrotransposon in the A20 \/ 2J B cell lymphoma .","gene":["H-2Eb","IAP retrotransposon"],"gene_indices_start":[15,29],"gene_indices_end":[20,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1281,"text":"The Lp mouse mutant provides a model for the severe human neural tube defect ( NTD ) , cranio-rachischisis .","gene":["Lp mouse mutant"],"gene_indices_start":[4],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1282,"text":"These effects were not seen with SHIP2 possessing a mutation in the SH2 domain ( R47G ) .","gene":["SHIP2","SH2 domain","R47G"],"gene_indices_start":[33,68,81],"gene_indices_end":[38,78,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1283,"text":"We have identified and characterized a vitamin D response element ( VDRE ) in the promoter of c-fos .","gene":["c-fos","VDRE","vitamin D response element"],"gene_indices_start":[39,68,94],"gene_indices_end":[65,72,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1286,"text":"Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+ , K ( + ) -ATPase distributions in polarized epithelia .","gene":["cadherin","Na+ , K ( + ) -ATPase"],"gene_indices_start":[54,115],"gene_indices_end":[62,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1287,"text":"These results suggest that gluconeogenic genes are derepressed upon binding of Cat8p , whose synthesis depends on the release of Cat4p ( Mig1p ) from the CAT8 promoter .","gene":["Mig1p","CAT8 promoter","Cat8p","Cat4p"],"gene_indices_start":[79,129,137,154],"gene_indices_end":[84,134,142,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1289,"text":"The interaction of AF-1 with proteins that regulate distinct steps of transcription may provide a mechanism for synergistic activation of gene expression by AF-1 .","gene":["AF-1","AF-1"],"gene_indices_start":[19,157],"gene_indices_end":[23,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1290,"text":"The N-terminal portion of Notch ( IC ) inhibited p50 DNA binding and interacted specifically with p50 subunit , not p65 of NF-kappaB .","gene":["p65","NF-kappaB","p50 subunit","Notch ( IC )","p50"],"gene_indices_start":[26,49,98,116,123],"gene_indices_end":[38,52,109,119,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1292,"text":"Expression of the human T cell receptor ( TCR ) alpha gene is regulated by a T cell-specific transcriptional enhancer that is located 4 . 5 kilobases ( kb ) 3' to the C alpha gene segment .","gene":["T cell receptor ( TCR ) alpha gene","C alpha gene segment"],"gene_indices_start":[24,167],"gene_indices_end":[58,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1294,"text":"Infectious mutant virus progeny was obtained only on complementing gK-expressing cells , suggesting that gK has an important function in the replication cycle .","gene":["gK"],"gene_indices_start":[105],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1295,"text":"The amino acid sequence of the protein in the region of the specificity pocket is similar to that of S . griseus proteases A , B , and C .","gene":["S . griseus proteases A , B , and C"],"gene_indices_start":[101],"gene_indices_end":[136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1298,"text":"The partial ORF was found to be identical to the C terminus of HrpJ2 .","gene":["HrpJ2"],"gene_indices_start":[63],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1299,"text":"Expression of thiamin biosynthetic genes ( thiCOGE ) and production of symbiotic terminal oxidase cbb3 in Rhizobium etli .","gene":["thiamin biosynthetic genes","symbiotic terminal oxidase cbb3","thiCOGE"],"gene_indices_start":[14,43,71],"gene_indices_end":[40,50,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1303,"text":"These regions may be differentially involved in tissue-specificity , and \/ or circadian regulation , of the human hPer1 gene transcription .","gene":["human hPer1 gene"],"gene_indices_start":[108],"gene_indices_end":[124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1304,"text":"Polyclonal antiserum generated to the fusion protein was capable of detecting 42- and 46-kilodalton polypeptides from virus particles ; both polypeptides were also shown to contain HBsAg determinants .","gene":["HBsAg determinants"],"gene_indices_start":[181],"gene_indices_end":[199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1313,"text":"GCD10 was first identified genetically as a translational repressor of GCN4 .","gene":["GCD10","GCN4"],"gene_indices_start":[0,71],"gene_indices_end":[5,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1314,"text":"Analysis of a Mac1p mutant , refractile for copper-dependent repression of the Cu ( I ) transport genes , showed an aberrant pattern of CUP1 expression and copper sensitivity .","gene":["Mac1p mutant","Cu ( I ) transport genes","CUP1"],"gene_indices_start":[14,79,136],"gene_indices_end":[26,103,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1316,"text":"Stromelysin-1 , matrix metalloproteinase-3 ( MMP-3 ) , is an important endopeptidase selectively expressed by somatic cells in organ tissues .","gene":["Stromelysin-1","MMP-3","endopeptidase","matrix metalloproteinase-3"],"gene_indices_start":[0,16,45,71],"gene_indices_end":[13,42,50,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1319,"text":"Each repeat consists of 12 nt , coding for the reiterated sequence , K \/ NPAG .","gene":["K \/ NPAG"],"gene_indices_start":[69],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1320,"text":"Purification of MvaT enriched for two polypeptides of approximate molecular mass 15 kDa and 16 kDa , designated P15 and P16 .","gene":["P15","P16","MvaT"],"gene_indices_start":[16,112,120],"gene_indices_end":[20,115,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1322,"text":"AB004534 .","gene":["AB004534"],"gene_indices_start":[0],"gene_indices_end":[8],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1326,"text":"Haploid cells of mating type A of the basidiomycetous yeast Rhodosporidium toruloides secrete a mating pheromone , rhodotorucine A , which is an undecapeptide containing S-farnesyl cysteine at its carboxy terminus .","gene":["rhodotorucine A"],"gene_indices_start":[115],"gene_indices_end":[130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1329,"text":"The transcription and alternative splicing of human ORL1 and GAIP are cell-type specific .","gene":["GAIP","human ORL1"],"gene_indices_start":[46,61],"gene_indices_end":[56,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1333,"text":"The similar phenotypes of bur6 and bur3 ( mot1 ) mutations suggest that Bur6p and Mot1p have related , but not identical , functions in modulating the activity of the general transcription machinery in vivo .","gene":["mot1","bur6","Bur6p","bur3","Mot1p"],"gene_indices_start":[26,35,42,72,82],"gene_indices_end":[30,39,46,77,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1334,"text":"Escherichia coli BL21 ( DE3 ) plysS , harbouring a recombinant plasmid containing the catalase-peroxidase gene , produced a large amount of proteins that co-migrated on SDS \/ PAGE with the native enzyme .","gene":["catalase-peroxidase gene"],"gene_indices_start":[86],"gene_indices_end":[110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1335,"text":"Uracil DNA glycosylase catalyzes the initial step in the repair pathway that removes potentially mutagenic uracil from duplex DNA .","gene":["Uracil DNA glycosylase"],"gene_indices_start":[0],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1336,"text":"Disruption of re-replication control by overexpression of human ORC1 in fission yeast .","gene":["human ORC1"],"gene_indices_start":[58],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1337,"text":"Whereas Smad2 was rapidly phosphorylated by TGF-beta and involved in the initial activation of Agc expression in confluent cells , Smad2 activation was not required for maintaining the high level of Agc expression .","gene":["Agc","Smad2","Smad2","TGF-beta","Agc"],"gene_indices_start":[8,44,95,131,199],"gene_indices_end":[13,52,98,136,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1339,"text":"Both alleles are functionally expressed and are distributed within CD4+ \/ CD8+ T cell subsets .","gene":["CD4+ \/ CD8+"],"gene_indices_start":[67],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1341,"text":"These show that the collagen in this tissue is modified compared with that in tendon .","gene":["collagen"],"gene_indices_start":[20],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1342,"text":"Taken together , these data indicate that the VirD2 omega domain is important for efficient T-DNA integration .","gene":["VirD2 omega domain"],"gene_indices_start":[46],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1343,"text":"The spontaneous mutation blocking pca gene expression was located in the promoter for the pca operon .","gene":["pca operon","pca gene"],"gene_indices_start":[34,90],"gene_indices_end":[42,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1344,"text":"The binding specificity of this protein was compared to that of human E2F using a number of mutant E2F sites as competitors .","gene":["mutant E2F sites","human E2F"],"gene_indices_start":[64,92],"gene_indices_end":[73,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1346,"text":"We also isolated two alternatively spliced forms of human CD6 cDNA lacking sequences encoding membrane-proximal regions of the cytoplasmic domain which maintain the same reading frame as CD6-PB1 .","gene":["human CD6 cDNA","CD6-PB1"],"gene_indices_start":[52,187],"gene_indices_end":[66,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1347,"text":"Eight CAD patients who were matched to the treated patients for age ( + \/ -3 years ) , baseline low density lipoprotein ( + \/ -5 mg \/ dL ) , and triglycerides ( + \/ -50 mg \/ dL ) but who had never been treated with lipid-lowering drugs were selected as controls .","gene":["low density lipoprotein"],"gene_indices_start":[96],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1349,"text":"The characterization of the promoter region indicated that three distinct regulatory elements corresponding to an AP-1 binding site ( or TRE ) , a PRDII \/ kappaB domain , and a CAAT box are involved in the activation by pp60 ( v- ) src .","gene":["pp60 ( v- ) src","AP-1 binding site","PRDII \/ kappaB domain","TRE"],"gene_indices_start":[114,137,147,220],"gene_indices_end":[131,140,168,235],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1350,"text":"The -64 \/ -37 region interacted with purified Sp1 and an unidentified protein ( s ) , proximal regulatory factor ( s ) I ( PRF-I ) .","gene":["PRF-I","Sp1","proximal regulatory factor ( s ) I"],"gene_indices_start":[46,86,123],"gene_indices_end":[49,120,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1351,"text":"Although most SH2-pTyr interactions occur between two different types of molecules , some appear to involve only a single molecular type .","gene":["SH2-pTyr"],"gene_indices_start":[14],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1352,"text":"From an RNK-16 lambda-gt11 library , we have isolated and sequenced a novel cDNA rat NK cell protease 1 ( RNKP-1 ) that has characteristics unique to serine proteases .","gene":["serine proteases","rat NK cell protease 1","RNKP-1"],"gene_indices_start":[81,106,150],"gene_indices_end":[103,112,166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1353,"text":"Similarly , in mammalian cells PBP74 is synthesized as a pre-protein that requires membrane potential-dependent import into mitochondria for its maturation .","gene":["PBP74"],"gene_indices_start":[31],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1354,"text":"The M reading frame differed from the reported sequence by a single nucleotide corresponding to a conservative lysine to arginine amino acid substitution near the carboxy-terminus conserved among the M proteins of paramyxoviruses .","gene":["M proteins","M reading frame"],"gene_indices_start":[4,200],"gene_indices_end":[19,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1356,"text":"Although it is well known that calcium channel blockers can influence contraction of vascular smooth muscle , there is less knowledge on its effect on excitation contraction coupling in the endocrine glands and more specifically on insulin and glucagon release .","gene":["insulin"],"gene_indices_start":[232],"gene_indices_end":[239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1358,"text":"Clinical applications of inhibition of beta-adrenergic receptors with propranolol .","gene":["beta-adrenergic receptors"],"gene_indices_start":[39],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1366,"text":"In fact , SPT activity in the fly expressing epitope-tagged Lace was absorbed by epitope-specific antibody .","gene":["SPT","Lace"],"gene_indices_start":[10,60],"gene_indices_end":[13,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1370,"text":"In this study , we investigated the signal transduction pathways that are involved in OM-induced LDLR transcription .","gene":["LDLR"],"gene_indices_start":[97],"gene_indices_end":[101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1371,"text":"The hexanucleotide 5'-TGTCCT-3' , thought to be important for GRE activity , not only was found in this sequence and in the 5'-flanking region , but also was present twice in the 3' end of the gene that did not show specific receptor binding .","gene":["hexanucleotide 5'-TGTCCT-3'","GRE"],"gene_indices_start":[4,62],"gene_indices_end":[31,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1373,"text":"Mutations at the extreme C-terminus of EIAV Tat impaired both RNA binding and activation domain functions , suggesting effects on secondary or tertiary structure .","gene":["EIAV Tat"],"gene_indices_start":[39],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1374,"text":"Repeated efforts to isolate recombinant baculoviruses containing a wild-type kinase failed , whereas recombinants expressing a nonfunctional kinase with a catalytic domain II mutation were readily isolated .","gene":["domain II","wild-type kinase","kinase"],"gene_indices_start":[67,141,165],"gene_indices_end":[83,147,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1376,"text":"RT-PCR was performed using previously reported degenerate oligonucleotide primers to the ligand binding domain ( LBD ) of known beta integrin subunits and Bge cDNA .","gene":["Bge cDNA","beta integrin subunits"],"gene_indices_start":[128,155],"gene_indices_end":[150,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1378,"text":"Efficient phosphorylation of BRDG1 by Tec required the PH and SH2 domains as well as the kinase domain of the latter .","gene":["BRDG1","PH","Tec","SH2 domains"],"gene_indices_start":[29,38,55,62],"gene_indices_end":[34,41,57,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1380,"text":"With this GH and estrogen treatment regimen , most girls with TS can grow and develop much more in conformity with their healthy peers .","gene":["GH"],"gene_indices_start":[10],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1383,"text":"With regard to nonhematologic toxicities , diarrhea , infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2% of cycles , but were tolerable and reversible .","gene":["serum alkaline phosphatase"],"gene_indices_start":[77],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1386,"text":"In addition , double mutants with either dim1-delta or dim2-1 and the endocytosis mutants end4-1 or act1-1 displayed synthetic growth defects , indicating that the DIM gene products function in a common or parallel endocytic pathway .","gene":["act1-1","dim1-delta","dim2-1","mutants end4-1","DIM gene products"],"gene_indices_start":[41,55,82,100,164],"gene_indices_end":[51,61,96,106,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1387,"text":"35 patients with acute arterial occlusions [ 27 ] and graft thromboses [ 8 ] , responsible for severe and recent ischemia , were treated by fibrinolytic therapy ( Urokinase : 1 000 units \/ kg \/ hour , and Lys Plasminogen ) .","gene":["Urokinase","Plasminogen"],"gene_indices_start":[163,209],"gene_indices_end":[172,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1389,"text":"An examination of the properties of sequences surrounding ARS1 left open the possibility that ABFI enhances the initiation of DNA replication at ARS1 by transcriptional activation .","gene":["ARS1","ARS1","ABFI"],"gene_indices_start":[58,94,145],"gene_indices_end":[62,98,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1390,"text":"The intron is capable of splicing despite the fact that both the EBS1 \/ IBS1 and the EBS2 \/ IBS2 sequence motifs , thought to be necessary for correct splicing , extend over 5 instead of 6 bp .","gene":["EBS2 \/ IBS2 sequence motifs","EBS1 \/ IBS1"],"gene_indices_start":[65,85],"gene_indices_end":[76,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1392,"text":"The association of p255 with splicing complexes is suggested by the finding that mAb CC3 can inhibit in vitro splicing and immunoprecipitate pre-messenger RNA and splicing products .","gene":["p255","mAb CC3"],"gene_indices_start":[19,81],"gene_indices_end":[23,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1394,"text":"Rather , usp is required in late third instar larvae for appropriate developmental and transcriptional responses to the ecdysone pulse that triggers puparium formation .","gene":["usp"],"gene_indices_start":[9],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1397,"text":"In the present study , we sought to investigate whether constitutive NF-kappaB activity in chronically HIV-1-infected promonocytic U937 ( U9-IIIB ) and myeloblastic PLB-985 ( PLB-IIIB ) cells affects apoptotic signaling .","gene":["constitutive NF-kappaB"],"gene_indices_start":[56],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1402,"text":"In Rat-1a cells the expression of human c-jun mRNA was associated with the ability to clone in soft agarose and form tumors in nude mice .","gene":["human c-jun mRNA"],"gene_indices_start":[34],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1403,"text":"Carbonic anhydrase V ( CA V ) is expressed in mitochondrial matrix in liver and several other tissues .","gene":["CA V","Carbonic anhydrase V"],"gene_indices_start":[0,23],"gene_indices_end":[20,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1408,"text":"We show that stimulation of resting splenic B cells with CD40L-expressing Sf9 cells induces germ-line gamma 1 and epsilon transcripts independently of cytokines .","gene":["gamma 1","epsilon transcripts"],"gene_indices_start":[102,114],"gene_indices_end":[109,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1409,"text":"Routine blood examination showed leukocytosis , thrombocytopenia , positive CRP , and elevated myocardial enzymes .","gene":["CRP"],"gene_indices_start":[76],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1414,"text":"Mutational analysis of chromosomal segment 64AB , a region containing the glutamic acid decarboxylase gene .","gene":["glutamic acid decarboxylase gene"],"gene_indices_start":[74],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1415,"text":"Substitution of the DR1 beta chain with H-2E beta k led to a dramatic loss of recognition ; alpha chain substitution had a less marked effect .","gene":["H-2E beta k","DR1 beta chain"],"gene_indices_start":[20,40],"gene_indices_end":[34,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1416,"text":"In contrast to the selective expression of the receptor , FL expression was detected in 90-100% of the various cell types of leukemia cell lines from all hematopoietic cell lineages .","gene":["FL"],"gene_indices_start":[58],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1417,"text":"Antibodies to the human PTS1R recognize this protein in human , monkey , rat , and hamster cells .","gene":["human PTS1R"],"gene_indices_start":[18],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1418,"text":"The combination of Pitx2 and another homeodomain protein , Pit-1 , yielded a synergistic 55-fold activation of the prolactin promoter in transfection assays .","gene":["prolactin promoter","homeodomain protein","Pit-1","Pitx2"],"gene_indices_start":[19,37,59,115],"gene_indices_end":[24,56,64,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1419,"text":"Consistent with the specificity observed for the interaction of DmCKIIalpha with these bHLH proteins , sequence alignment suggests that only m5 , m7 , and m8 contain a consensus site for phosphorylation by CKII within a subdomain unique to these three proteins .","gene":["m8","bHLH proteins","CKII","m5","DmCKIIalpha","m7"],"gene_indices_start":[64,87,141,146,155,206],"gene_indices_end":[75,100,143,148,157,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1420,"text":"The transcription start point of the proximal promoter aligns to that of mouse promoter P3 and lies within a conserved region of sequence .","gene":["mouse promoter P3"],"gene_indices_start":[73],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1422,"text":"The phosphorylation efficiency is improved by increasing the number of N-terminal arginine residues and by moving the arginyl cluster one residue further away from the serine , the nonapeptide ( Arg ) 4-Ala-Ala-Ser-Val-Ala being the best substrate among all the short peptides tested ( Km = 15 microM ) .","gene":["nonapeptide ( Arg ) 4-Ala-Ala-Ser-Val-Ala"],"gene_indices_start":[181],"gene_indices_end":[222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1425,"text":"Analysis of homologous DNA sequences within the first intron of the mouse and human mts1 genes : kB-like site and microsatellite DNA .","gene":["kB-like site","mouse and human mts1 genes"],"gene_indices_start":[68,97],"gene_indices_end":[94,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1426,"text":"The medium chains of these complexes , mu1 and mu2 , have been implicated in two types of interaction : assembly with the beta1 and beta2 chains of the corresponding complexes and recognition of tyrosine-based sorting signals .","gene":["mu2","mu1","beta1 and beta2 chains"],"gene_indices_start":[39,47,122],"gene_indices_end":[42,50,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1427,"text":"The promoter was stimulated 8-20-fold by phorbol esters accounting for the previously observed transcriptional activation of protein kinase C beta .","gene":["protein kinase C beta"],"gene_indices_start":[125],"gene_indices_end":[146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1429,"text":"Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters .","gene":["RFX5","MHC-II promoters","RFX complex","RFXAP"],"gene_indices_start":[21,30,68,83],"gene_indices_end":[25,35,79,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1430,"text":"In CV-1 cells , cotransfection of the retinoid and estrogen receptors led to mutual inhibition of the other's activity , while an RA-dependent inhibition of ER activity was observed in breast cancer cells .","gene":["ER","retinoid and estrogen receptors"],"gene_indices_start":[38,157],"gene_indices_end":[69,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1434,"text":"A transgenic complementation assay was used to test whether NIa supplied in trans could rescue amplification-defective viral genomes encoding altered NIa proteins .","gene":["NIa proteins","NIa"],"gene_indices_start":[60,150],"gene_indices_end":[63,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1436,"text":"Initial results indicate that this 23S pre-rRNA is the same as the species detected on depletion of the small nucleolar RNA-associated proteins NOP1 and GAR1 and in an snr10 mutant strain .","gene":["GAR1","NOP1","small nucleolar RNA-associated proteins","snr10 mutant","23S pre-rRNA"],"gene_indices_start":[35,104,144,153,168],"gene_indices_end":[47,143,148,157,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1437,"text":"Complementary DNAs encompassing the coat protein coding and adjacent regions of Agropyron mosaic virus ( AgMV ) and Hordeum mosaic virus ( HoMV ) were cloned and sequenced .","gene":["coat protein"],"gene_indices_start":[36],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1438,"text":"To understand further the expression and regulation of the V1aR , we now describe the genomic characteristics , tissue expression , chromosomal localization , and regional mapping of the human V1aR gene , AVPR1A .","gene":["AVPR1A","V1aR","human V1aR gene"],"gene_indices_start":[59,187,205],"gene_indices_end":[63,202,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1439,"text":"Vaccinia virus-expressed , purified full-length HPV-16 and BPV-1 E2 proteins bound a consensus E2 site with high specific affinities ( Kd = approximately 10 ( -9 ) M ) and stimulated in vitro transcription up to six- to eightfold .","gene":["E2 site","full-length HPV-16 and BPV-1 E2 proteins"],"gene_indices_start":[36,95],"gene_indices_end":[76,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1440,"text":"Genes for ocs element binding factors ( OBFs ) , belonging to a specific class of basic-region leucine zipper ( bZIP ) transcription factors , have been isolated in a number of plants .","gene":["basic-region leucine zipper ( bZIP ) transcription factors","ocs element binding factors","OBFs"],"gene_indices_start":[10,40,82],"gene_indices_end":[37,44,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1441,"text":"Interestingly , highly charged residues were abundantly possessed in the carboxy-terminal part of the MDV2 UL10 protein .","gene":["MDV2 UL10 protein"],"gene_indices_start":[102],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1442,"text":"By using lambda gt11 expression cloning with oligonucleotides corresponding to the human immunodeficiency virus 1 TATA element , we report the identification of a cellular protein with a calculated molecular mass of 123 kDa that we designate TATA element modulatory factor ( TMF ) .","gene":["TATA element modulatory factor","TMF"],"gene_indices_start":[242,275],"gene_indices_end":[272,278],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1443,"text":"We show here that RA and E1A induce phosphorylation of the E1A-associated 300 kDa protein ( p300 ) during the differentiation of F9 cells .","gene":["p300","E1A","E1A-associated 300 kDa protein"],"gene_indices_start":[25,59,92],"gene_indices_end":[28,89,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1448,"text":"Successful interaction of ARF and PKC-alpha with PLD1 was not achieved , but a C-terminal fragment of human PLD1 ( denoted \"D4\" ) interacted with the active mutant of RhoA , RhoAVal-14 .","gene":["RhoA","human PLD1","PLD1","RhoAVal-14","ARF","PKC-alpha"],"gene_indices_start":[26,34,49,102,167,174],"gene_indices_end":[29,43,53,112,171,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1449,"text":"Repetitive sequences are present in at least three introns of the cytochrome P-450PBc2 gene , but not in exons or the 5'-flanking region .","gene":["cytochrome P-450PBc2 gene"],"gene_indices_start":[66],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1450,"text":"( GUT ) Sera of 30 montoux negative healthy adults ( age \/ sex matched ) were taken as control by detecting IgG anti bodies to A60 antigen .","gene":["A60 antigen","IgG anti bodies"],"gene_indices_start":[108,127],"gene_indices_end":[123,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1451,"text":"Using immunolocalization , we observe that ACE3 , a 440-bp chorion element that contains information sufficient to drive amplification , directs DmORC localization in follicle cells .","gene":["ACE3"],"gene_indices_start":[43],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1452,"text":"E2F activity is regulated in part by the retinoblastoma family of tumor suppressor proteins .","gene":["E2F","retinoblastoma family of tumor suppressor proteins"],"gene_indices_start":[0,41],"gene_indices_end":[3,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1455,"text":"A cDNA encoding the NF-4FB enhancer binding protein has been cloned by screening a lambda gt11 cDNA library with a rabiolabelled oligonucleotide corresponding to the NF-4FB recognition sequence .","gene":["NF-4FB recognition sequence","NF-4FB enhancer binding protein"],"gene_indices_start":[20,166],"gene_indices_end":[51,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1456,"text":"The aim of the study was to correlate the responsiveness to bronchoprovocation with methacholine in subjects a with allergic rhinitis during and out of the pollen season with total serum IgE and blood eosinophils .","gene":["IgE"],"gene_indices_start":[187],"gene_indices_end":[190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1457,"text":"The Siglecs are a subfamily of I-type lectins ( immunoglobulin superfamily proteins that bind sugars ) that specifically recognize sialic acids .","gene":["Siglecs","immunoglobulin superfamily proteins","I-type lectins"],"gene_indices_start":[4,31,48],"gene_indices_end":[11,45,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1459,"text":"Immunelectrophoretic pattern of Wassermann reagin and comparison of the appearance time between RPCF and FTA antibodies .","gene":["FTA antibodies","RPCF"],"gene_indices_start":[96,105],"gene_indices_end":[100,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1461,"text":"In this report , we investigate the mechanism underlying Ras activation upon stimulation of these two types of receptors in hematopoietic cells .","gene":["Ras"],"gene_indices_start":[57],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1463,"text":"OKA and calyculin A do not decrease OCFRE DNA-protein interactions , suggesting that important protein-protein interactions are phosphatase regulated .","gene":["OCFRE"],"gene_indices_start":[36],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1464,"text":"In addition , media containing F beta alpha \/ CG beta displayed high-affinity binding to both CG and FSH receptors .","gene":["F beta alpha \/ CG beta","FSH receptors","CG"],"gene_indices_start":[31,94,101],"gene_indices_end":[53,96,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1465,"text":"Antisense transcription of a murine FGFR-3 psuedogene during fetal developement .","gene":["murine FGFR-3 psuedogene"],"gene_indices_start":[29],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1468,"text":"Both BG and IRI concentrations during the OGTT were the lowest in body builders , medium in controls , and the highest in obese men .","gene":["IRI"],"gene_indices_start":[12],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1472,"text":"A decrease of the lysozyme activity coincided with the clinical improvement of the bacterial meningitis .","gene":["lysozyme"],"gene_indices_start":[18],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1474,"text":"In situ copper-phenanthroline footprinting of individual gel shift assembly intermediates shows that on the 302-nucleotide G4oric , the first two SSB tetramers assemble at random , but the addition of more SSB tetramers results in formation of a unique structure .","gene":["SSB tetramers","SSB tetramers"],"gene_indices_start":[146,206],"gene_indices_end":[159,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1476,"text":"Cellular Csk was associated with several phosphoproteins , some of which were interacting with the Csk SH2 domain .","gene":["Cellular Csk","Csk","SH2 domain"],"gene_indices_start":[0,99,103],"gene_indices_end":[12,102,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1477,"text":"Previous studies characterized a cytokine-inducible , functional nuclear factor ( NF ) -kappaB consensus element in the immediate 5' regulatory region of the MGSA \/ GRO-alpha gene at -78 bp .","gene":["MGSA \/ GRO-alpha gene","nuclear factor ( NF ) -kappaB consensus element"],"gene_indices_start":[65,158],"gene_indices_end":[112,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1478,"text":"Enhancer activity requires both the AP-1 site and these adjacent sequences .","gene":["AP-1 site"],"gene_indices_start":[36],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1482,"text":"Between acoR and acoXABC , two different types of sequences with dual rotational symmetry [ CAC- ( N11 to N18 ) -GTG and TGT- ( N10 to N14 ) -ACA ] were found ; these sequences are similar to NtrC and NifA upstream activator sequences , respectively .","gene":["NifA upstream activator sequences","acoXABC","acoR","NtrC"],"gene_indices_start":[8,17,192,201],"gene_indices_end":[12,24,196,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1486,"text":"The complete response ( CR ) rate was 34% in the CODE with rhG-CSF group and 23% in the CODE alone group ; the median survival was 59 and 32 weeks , respectively , in these groups ( P = 0 . 004 ) .","gene":["rhG-CSF"],"gene_indices_start":[59],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1487,"text":"The data further indicate that the IL-7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells .","gene":["STATs","IL-7R alpha chains","JAKs"],"gene_indices_start":[35,97,106],"gene_indices_end":[53,101,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1488,"text":"Chromatin repression of these replacement genes would be avoided , consistent with the high , constitutive expression of replacement H3 histone genes in plants .","gene":["H3 histone genes"],"gene_indices_start":[133],"gene_indices_end":[149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1493,"text":"USF synthesized in an in vitro transcription and translation system also binds to the ADH promoter as well as to the MLP .","gene":["USF","ADH promoter"],"gene_indices_start":[0,86],"gene_indices_end":[3,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1498,"text":"NOT4 interacts with NOT1 and NOT3 in the two-hybrid assay , and overexpression of NOT3 or NOT4 suppresses not1 and not2 mutations .","gene":["not1","NOT1","NOT4","NOT3","not2","NOT3","NOT4"],"gene_indices_start":[0,20,29,82,90,106,115],"gene_indices_end":[4,24,33,86,94,110,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1502,"text":"Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2 \/ Mpr gene .","gene":["Igf2","Mpr"],"gene_indices_start":[72,79],"gene_indices_end":[76,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1508,"text":"The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid .","gene":["blood haemoglobin"],"gene_indices_start":[74],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1509,"text":"An in vivo ZAP-70 substrate , SLP-76 , implicated in Erk activation , also became rapidly tyrosine-phosphorylated in Jurkat cells , but not in P116 cells , upon treatment with H2O2 .","gene":["SLP-76","ZAP-70","Erk"],"gene_indices_start":[11,30,53],"gene_indices_end":[17,36,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1510,"text":"Promoter activity was dose-dependently inhibited by cotransfection with either ras or mos oncogenes , but oncogene inhibition was reversed and the overall activity increased when cells were treated with the MAP kinase kinase ( MKK ) inhibitor PD98059 .","gene":["MKK","ras","mos oncogenes","MAP kinase kinase"],"gene_indices_start":[79,86,207,227],"gene_indices_end":[82,99,224,230],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1512,"text":"In earlier studies we identified several regulatory elements that control transcriptional activation and aerobic repression of one of these genes , COX5b .","gene":["COX5b"],"gene_indices_start":[148],"gene_indices_end":[153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1513,"text":"Furthermore , we have identified a soluble form of ERp57 \/ GRP58 by Western blotting and biosynthetic labeling .","gene":["ERp57 \/ GRP58"],"gene_indices_start":[51],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1517,"text":"Collectively , these and previously published data suggest a model where NS1 recruits eIF4GI specifically to the 5' untranslated region ( 5' UTR ) of the viral mRNA , allowing for the preferential translation of the influenza virus messengers .","gene":["NS1","eIF4GI"],"gene_indices_start":[73,86],"gene_indices_end":[76,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1519,"text":"HEED was found to bind to MA protein in vitro , as efficiently as in vivo in yeast cells .","gene":["MA protein","HEED"],"gene_indices_start":[0,26],"gene_indices_end":[4,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1520,"text":"Patients were randomly assigned to treatment with the ACE inhibitor perindopril ( and the diuretic indapamide for those with no definite indication for or contraindication to treatment with a diuretic ) or matching placebo ( s ) .","gene":["ACE"],"gene_indices_start":[54],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1521,"text":"Northern analysis of RNA samples isolated from ammonium-grown cultures of the ntcA mutant showed reduced amounts of glnA message and the absence of a 1 . 7-kb transcript .","gene":["ntcA mutant","glnA message"],"gene_indices_start":[78,116],"gene_indices_end":[89,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1522,"text":"RVR 'loss of function' studies by constitutive over-expression of a dominant negative RVR delta E resulted in increased levels of p21Cip1 \/ Waf1 and myogenin mRNAs after serum withdrawal .","gene":["p21Cip1","Waf1","RVR","RVR delta E","myogenin mRNAs"],"gene_indices_start":[0,86,130,140,149],"gene_indices_end":[3,97,137,144,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1523,"text":"Consistent with this , purified Dlk phosphorylated core histones H3 , H2A and H4 as exogenous substrates and endogenous histone H3 in kinase assays with nuclear extracts .","gene":["Dlk","H2A","histone H3","H4","histones H3"],"gene_indices_start":[32,56,70,78,120],"gene_indices_end":[35,67,73,80,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1526,"text":"The structural gene encoding the novel lantibiotic epilancin K7 from Staphylococcus epidermidis K7 was cloned and its nucleotide sequence was determined .","gene":["epilancin K7"],"gene_indices_start":[51],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1527,"text":"Overexpression of H411 cDNA in the RAW 264 . 7 macrophage cell line promoted an increased growth rate , suggesting that expression of H411 is part of the proliferative cell response to LPS .","gene":["H411","H411 cDNA"],"gene_indices_start":[18,134],"gene_indices_end":[27,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1529,"text":"cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit .","gene":["mouse DNA polymerase epsilon catalytic subunit","gene Pole1"],"gene_indices_start":[40,59],"gene_indices_end":[50,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1530,"text":"A transcription factor exclusion assay was used to show that the PCF1 mutation affects two distinct stages in transcription : one prior to and one after stable complex formation ; and that these effects are mediated by a component of the stable complex .","gene":["PCF1 mutation"],"gene_indices_start":[65],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1532,"text":"The 1489-base pair EFIA cDNA encodes a 322-amino acid protein which is nearly identical to two previously described human DNA binding proteins .","gene":["EFIA"],"gene_indices_start":[19],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1533,"text":"PRL receptor also activates SHP-2 , a cytosolic tyrosine phosphatase .","gene":["cytosolic tyrosine phosphatase","PRL receptor","SHP-2"],"gene_indices_start":[0,28,38],"gene_indices_end":[12,33,68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1537,"text":"60 patients were entered into a randomised study comparing vindesine ( 3 mg \/ m2 \/ week ) plus interferon-alpha 2b ( 6 U \/ m2 3 times per week ) to vindesine alone or to interferon alone for the treatment of metastatic malignant melanoma .","gene":["interferon-alpha 2b","interferon"],"gene_indices_start":[95,170],"gene_indices_end":[114,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1538,"text":"However , mutations in the HNF-4 binding site on element CIIB and inhibition of HNF-4 synthesis in HepG2 cells by antisense HNF-4 constructs decreased the apoCII promoter activity to 25-40% of the control , indicating that HNF-4 is a positive regulator of the apoCII gene .","gene":["apoCII gene","HNF-4 constructs","HNF-4","element CIIB","HNF-4 binding site","HNF-4","apoCII promoter"],"gene_indices_start":[27,49,80,124,155,223,260],"gene_indices_end":[45,61,85,140,170,228,271],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1539,"text":"Our results indicate that D ( 4 ) and D ( 2L ) receptors activate the ERK kinase cascade by first mobilizing signaling by the PDGF receptor , followed by the subsequent activation of ERK1 \/ 2 by pathways associated with this receptor tyrosine kinase .","gene":["ERK1 \/ 2","D ( 2L ) receptors","PDGF receptor","ERK kinase","D ( 4 )","receptor tyrosine kinase"],"gene_indices_start":[26,38,70,126,183,225],"gene_indices_end":[33,56,80,139,191,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1542,"text":"The FAS promoter was up-regulated by insulin through the proximal insulin response sequence containing an E-box motif at the -65-base pair position .","gene":["FAS promoter","insulin","insulin response sequence"],"gene_indices_start":[4,37,66],"gene_indices_end":[16,44,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1543,"text":"In cell lines transformed by BCR \/ ABL , CRKL was tyrosine phosphorylated , while CRK was not .","gene":["BCR \/ ABL","CRKL","CRK"],"gene_indices_start":[29,41,82],"gene_indices_end":[38,45,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1544,"text":"The two-hybrid assay was then performed using full-length genes of CI , HC-Pro , P1 , P3 , and CP , but no heterologous interactions were detected .","gene":["P1","CP","CI","P3","HC-Pro"],"gene_indices_start":[67,72,81,86,95],"gene_indices_end":[69,78,83,88,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1545,"text":"The nucleolin gene extends over 9000 base-pairs and is split into 14 exons that encode the 706 amino acid residues of the protein .","gene":["nucleolin gene"],"gene_indices_start":[4],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1548,"text":"We also present evidence that human HYAL1 is identical to an uncharacterized gene positionally cloned by others from chromosome 3p21 . 3 that is homozygously deleted in several small-cell lung carcinoma cell lines .","gene":["human HYAL1"],"gene_indices_start":[30],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1549,"text":"Furthermore , strains with mutant RPM1 genes also accumulate precursor Rpm1r , suggesting that mutations in either gene can lead to similar biogenesis defects .","gene":["mutant RPM1 genes","precursor Rpm1r"],"gene_indices_start":[27,61],"gene_indices_end":[44,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1551,"text":"STK \/ RON-expressing Ba \/ F3 pro-B cells ( BaF \/ STK ) exhibited MSP-dependent growth , whereas STK \/ RON-expressing mouse erythroleukaemia cells ( MEL \/ STK ) displayed MSP-induced apoptosis .","gene":["STK \/","STK"],"gene_indices_start":[96,154],"gene_indices_end":[101,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1552,"text":"Also , the BALB \/ c gene contains a single substitution in a conserved octamer sequence approximately equal to 100 nucleotides upstream of the coding region , which could affect its expression .","gene":["BALB \/ c gene"],"gene_indices_start":[11],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1553,"text":"Immunological testing was performed on all brewery workers and some control volunteers using skin prick testing with hops , barley , and yeast antigens as well as other nonoccupational allergens , and by determining total serum IgE levels .","gene":["serum IgE"],"gene_indices_start":[222],"gene_indices_end":[231],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1554,"text":"Purified CarP binds in vitro to the carAB control region and protects against DNase I two approximately 25 bp long stretches , one of which is located just downstream of the GATC sequence .","gene":["carAB control region","DNase I","GATC sequence","CarP"],"gene_indices_start":[9,36,78,174],"gene_indices_end":[13,56,85,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1556,"text":"Prevention of maternal Rh sensitization : anti-Rh immune globulin .","gene":["anti-Rh immune globulin"],"gene_indices_start":[42],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1558,"text":"These mutations alter two regions of GAL4 protein : the DNA binding domain , and the transcription activation domain .","gene":["GAL4 protein"],"gene_indices_start":[37],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1566,"text":"The human U4 \/ U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p .","gene":["U4 \/ U6 snRNP","Prp3p","Prp4p"],"gene_indices_start":[10,117,127],"gene_indices_end":[23,122,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1567,"text":"The diagnostic accuracy of serum PE-1 was 0 . 80 , and that of amylase 0 . 97 .","gene":["PE-1","amylase"],"gene_indices_start":[33,63],"gene_indices_end":[37,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1574,"text":"Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1 .","gene":["mouse histone deacetylase 1"],"gene_indices_start":[49],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1575,"text":"Phorbol esters stimulated phosphorylation of CSK 35H proteins , thus emphasizing that sequences isolated according to PKC binding activity in vitro are also PKC substrates in vivo .","gene":["CSK 35H proteins","PKC","PKC"],"gene_indices_start":[45,118,157],"gene_indices_end":[61,121,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1577,"text":"TBP can be phosphorylated in vitro by extracts of U937 cells or by bacterially expressed activated ERK2 ; the phosphorylation sites were mapped to ERK kinase consensus sites in the TBP amino-terminal domain .","gene":["TBP","TBP amino-terminal domain","ERK kinase consensus sites","ERK2"],"gene_indices_start":[0,99,147,181],"gene_indices_end":[3,103,173,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1583,"text":"Deletion analysis showed that the -321 \/ +41 sequence was sufficient for both the constitutive promoter activity and auto-activation and electrophoretic mobility shift assays identified the interaction of C \/ EBPs and Sp1 to this region .","gene":["C \/ EBPs","Sp1"],"gene_indices_start":[205,218],"gene_indices_end":[213,221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1584,"text":"A reduction of the aspartate aminotransferase activity was observed from 800 mg \/ kg b . w . \/ d onwards .","gene":["aspartate aminotransferase"],"gene_indices_start":[19],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1585,"text":"Through two novel mechanisms , Arf inhibits the oncoprotein Hdm2 , a negative regulator of p53 .","gene":["p53","oncoprotein Hdm2","Arf"],"gene_indices_start":[31,48,91],"gene_indices_end":[34,64,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1587,"text":"On the basis of its bZIP structural homology , meq is perhaps the only member of the jun-fos gene family completely viral in origin .","gene":["jun-fos gene family","bZIP","meq"],"gene_indices_start":[20,47,85],"gene_indices_end":[24,50,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1588,"text":"Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity , the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity .","gene":["PEBP2","PEBP2 isoforms","GM-CSF promoter"],"gene_indices_start":[71,84,192],"gene_indices_end":[76,99,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1589,"text":"FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events .","gene":["FAK","transmembrane integrin receptor"],"gene_indices_start":[0,26],"gene_indices_end":[3,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1590,"text":"In concert with the coactivator CREB binding protein \/ p300 , which interacts with GABPalpha , the binding of GABPalpha and -beta to the dyad symmetry element controls the induction of IL-16 promoter in T cells .","gene":["GABPalpha and -beta","CREB binding protein \/ p300","IL-16 promoter","GABPalpha"],"gene_indices_start":[32,83,110,185],"gene_indices_end":[59,92,129,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1591,"text":"DNase I footprinting and electrophoretic mobility shift assays indicate that PBP binds to the half-site of each palindrome with the core recognition sequence TGGGAG .","gene":["core recognition sequence TGGGAG","DNase I","PBP"],"gene_indices_start":[0,77,132],"gene_indices_end":[7,80,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1593,"text":"In hemodialyzed patients ( Epo and Non-Epo group ) leptin levels were significantly higher when compared to CAPD patients ( Epo and Non-Epo group , respectively ) .","gene":["Epo","leptin","Epo"],"gene_indices_start":[27,51,124],"gene_indices_end":[30,57,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1597,"text":"DNase I footprinting and electrophoretic mobility shift analyses revealed two hepatocyte nuclear factor-1 ( HNF1 ) , three CCAAT \/ enhancer-binding protein ( C \/ EBP ) , and one consensus palindromic thyroid hormone response elements within the first 215 base pairs ( bp ) of the promoter sequence of rat Std .","gene":["DNase I","CCAAT \/ enhancer-binding protein","rat Std","HNF1","thyroid hormone response elements","hepatocyte nuclear factor-1","C \/ EBP"],"gene_indices_start":[0,78,108,123,158,200,301],"gene_indices_end":[7,105,112,155,165,233,308],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1599,"text":"Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase .","gene":["CD2 cytoplasmic domain","phosphoinositide 3-kinase"],"gene_indices_start":[49,144],"gene_indices_end":[71,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1601,"text":"Galphaq , Galpha12 , and Galpha13 , but not Galphai , activate SRF through RhoA .","gene":["Galpha12","Galphai","RhoA","Galpha13","SRF","Galphaq"],"gene_indices_start":[0,10,25,44,63,75],"gene_indices_end":[7,18,33,51,66,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1603,"text":"The malate synthase gene , MLS1 , of the yeast Saccharomyces cerevisiae is transcriptionally regulated by the carbon source in the growth medium .","gene":["malate synthase gene","MLS1"],"gene_indices_start":[4,27],"gene_indices_end":[24,31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1606,"text":"Mucin gene expression has been shown to be altered in many intestinal diseases and especially cancers of the gastrointestinal tract .","gene":["Mucin gene"],"gene_indices_start":[0],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1607,"text":"The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa .","gene":["collagenase"],"gene_indices_start":[41],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1610,"text":"C \/ EBP beta V > A selectively binds only the subset of C \/ EBP sites that are also DBP sites , both as oligonucleotides and within the natural contexts of the albumin and cholesterol hydroxylase promoters .","gene":["albumin","C \/ EBP sites","DBP sites","cholesterol hydroxylase promoters","C \/ EBP beta V"],"gene_indices_start":[0,56,84,160,172],"gene_indices_end":[14,69,93,167,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1614,"text":"Site-directed mutagenesis of CAR revealed that CAR residues Leu73 and Lys121 and \/ or Lys123 are critical contact residues , with Tyr80 and Tyr83 being peripherally involved in the binding interaction with the Ad5 , Ad9 , Ad12 , and Ad41L fiber knobs .","gene":["CAR","CAR residues Leu73 and Lys121 and \/ or Lys123"],"gene_indices_start":[29,47],"gene_indices_end":[32,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1615,"text":"The Prolactin levels were within the physiological norms ; the responses to TRH were normal , and elevated only in a few cases .","gene":["TRH","Prolactin"],"gene_indices_start":[4,76],"gene_indices_end":[13,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1616,"text":"To investigate the activity of TCF11 through this selected site , both alone and in the presence of MafG , we have used a transient transfection assay .","gene":["TCF11","MafG"],"gene_indices_start":[31,100],"gene_indices_end":[36,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1617,"text":"Interleukin-1 levels remained low throughout the course .","gene":["Interleukin-1"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1618,"text":"This dominant-negative effect of FRNK was reversed by a point mutation ( Leu-1034 to Ser ) which prevented FRNK localization to focal contact sites .","gene":["FRNK","FRNK"],"gene_indices_start":[33,107],"gene_indices_end":[37,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1620,"text":"Additionally , the mouse promoter contains 22 copies of a CT dinucleotide repeat sequence located approximately 155 bp 5' to exon 1 .","gene":["CT dinucleotide repeat sequence"],"gene_indices_start":[58],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1621,"text":"Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity , the Tyr-397 \/ SH2 domain binding site , and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required .","gene":["SH3 binding region","FAK kinase","FAK","FN","Tyr-397 \/ SH2 domain binding site","paxillin","FAK mutants","FAK C-terminal domain"],"gene_indices_start":[22,64,90,153,179,278,296,316],"gene_indices_end":[33,74,123,171,200,280,304,319],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1622,"text":"In contrast , over-expression of RAR beta only poorly restored differentiation , although it could replace RAR gamma for the activation of target genes .","gene":["RAR beta","RAR gamma"],"gene_indices_start":[33,107],"gene_indices_end":[41,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1627,"text":"The effect of these cell cycle regulators is not specific to the rap1s or hmr delta A mutation , since swi6 , swi4 , and clb5 mutations also suppress mutations in SIR1 , another gene implicated in the establishment of silencing .","gene":["swi6","rap1s","clb5 mutations","SIR1","swi4","hmr delta A mutation"],"gene_indices_start":[65,74,103,110,121,163],"gene_indices_end":[70,94,107,114,135,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1628,"text":"Some of the peptide : MBP fusions were also analyzed using surface plasmon resonance .","gene":["peptide : MBP fusions"],"gene_indices_start":[12],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1630,"text":"All 89 participating household members were anti-HIV seronegative , and 78 who were tested were serum p24 antigen negative .","gene":["serum p24 antigen"],"gene_indices_start":[96],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1631,"text":"In contrast , a Maf-related protein , Nrl , completely mimicked c-Maf actions .","gene":["Nrl","Maf-related protein","c-Maf"],"gene_indices_start":[16,38,64],"gene_indices_end":[35,41,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1632,"text":"TRAF2 is a potent activator of a 95-kDa serine \/ threonine kinase termed germinal center kinase related ( GCKR , also referred to as KHS1 ) , which signals activation of the SAPK pathway .","gene":["KHS1","GCKR","germinal center kinase related","TRAF2","SAPK","95-kDa serine \/ threonine kinase"],"gene_indices_start":[0,33,73,106,133,174],"gene_indices_end":[5,65,103,110,137,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1634,"text":"The TraD protein ( 83 , 899 Da ) contains three hydrophobic regions , of which two are located near the amino-terminal region .","gene":["TraD protein ( 83 , 899 Da )"],"gene_indices_start":[4],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1636,"text":"Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein .","gene":["transcription activation domain of stage-specific activator protein","ZFM1 protein"],"gene_indices_start":[6,74],"gene_indices_end":[18,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1639,"text":"In patients with type IA maple syrup urine disease , the E1alpha subunit is affected , resulting in the loss of E1 and branched-chain ketoacid dehydrogenase catalytic activities .","gene":["E1alpha subunit","branched-chain ketoacid dehydrogenase","E1"],"gene_indices_start":[57,112,119],"gene_indices_end":[72,114,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1641,"text":"These data indicate that the largest subunit of RNA polymerase II and TFIIB are important determinants of transcription start site selection in S . cerevisiae and suggest that this function might be conferred by interaction between these two proteins .","gene":["RNA polymerase II","TFIIB"],"gene_indices_start":[48,70],"gene_indices_end":[65,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1645,"text":"No relevant changes in heart rate , body weight , and plasma levels of renin activity and aldosterone concentration were observed .","gene":["renin"],"gene_indices_start":[71],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1646,"text":"The orf61 gene product , when expressed from an exogenous promoter , inhibited int-mediated integration at the chromosomal attB site .","gene":["chromosomal attB site","orf61 gene product"],"gene_indices_start":[4,111],"gene_indices_end":[22,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1651,"text":"Low MAO subjects showed a pattern of higher scores in KSP Impulsiveness , EPQ Neuroticism , and KSP Somatic Anxiety and Irritability and lower scores in KSP Socialization , in line with personality profiles found in alcoholics , psychopaths , and suicide attempters who also tend to have low platelet MAO activity .","gene":["MAO","MAO"],"gene_indices_start":[4,301],"gene_indices_end":[7,304],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1653,"text":"Next , we show that two EMS-induced mutations , previously shown to interact genetically with zipper ( Ebr ) , disrupt the RhoA locus .","gene":["Ebr","RhoA locus"],"gene_indices_start":[103,123],"gene_indices_end":[106,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1654,"text":"HSF binds DNA as a trimer , and additional trimers can bind DNA co-operatively .","gene":["HSF"],"gene_indices_start":[0],"gene_indices_end":[3],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1655,"text":"Apart from antimicrobial properties , recent data indicate that PMN also exert anti-inflammatory effects by stimulation and release of cytokine antagonists such as interleukin-1 receptor antagonist ( IL-1ra ) .","gene":["interleukin-1 receptor antagonist","IL-1ra"],"gene_indices_start":[164,200],"gene_indices_end":[197,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1656,"text":"Mouse Impact is a paternally expressed gene encoding an evolutionarily conserved protein of unknown function .","gene":["Mouse Impact"],"gene_indices_start":[0],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1657,"text":"BACKGROUND : Mitosis is regulated by MPF ( maturation promoting factor ) , the active form of Cdc2 \/ 28-cyclin B complexes .","gene":["maturation promoting factor","Cdc2 \/ 28-cyclin B complexes","MPF"],"gene_indices_start":[37,43,94],"gene_indices_end":[40,70,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1658,"text":"We report an example of an MDV-transformed T-lymphoblastoid cell line ( T9 ) expressing high levels of a truncated C-MYB protein as a result of RAV integration within one c-myb allele .","gene":["c-myb allele","truncated C-MYB protein"],"gene_indices_start":[105,171],"gene_indices_end":[128,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1659,"text":"The interaction of caffeine , theophylline and theobromine with monoamine oxidase inhibitors .","gene":["monoamine oxidase"],"gene_indices_start":[64],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1661,"text":"To gain an understanding of the mGSTM2 regulation , we have also cloned and analyzed its promoter region .","gene":["mGSTM2"],"gene_indices_start":[32],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1662,"text":"Mutations in three loci ( SIC1 , SWI5 , and RIC3 ) were identified .","gene":["SWI5","RIC3","SIC1"],"gene_indices_start":[26,33,44],"gene_indices_end":[30,37,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1663,"text":"Therefore , mechanisms that control activation of the MAP kinase cascade temporally and spatially may be important for specification of cellular responses .","gene":["MAP kinase cascade"],"gene_indices_start":[54],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1666,"text":"In H4IIE rat hepatoma cells , glucocorticoids , retinoic acid and cyclic AMP ( cAMP ) increase PEPCK gene transcription whereas insulin and phorbol esters have the opposite effect .","gene":["PEPCK gene","insulin"],"gene_indices_start":[95,128],"gene_indices_end":[105,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1669,"text":"The E1 nuclear transport motif is highly conserved in the animal and human papillomaviruses and is encoded in a similar region in the related E1 genes .","gene":["E1 nuclear transport motif","E1 genes"],"gene_indices_start":[4,142],"gene_indices_end":[30,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1670,"text":"Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases .","gene":["LAGLIDADG homing endonucleases"],"gene_indices_start":[43],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1671,"text":"The gene is contained within a 1 . 8-kilobase AccI-EcoRI restriction fragment mapping at map coordinates 0 . 136 to 0 . 148 in the UL region of the EHV-1 genome and is transcribed from right to left .","gene":["UL region","1 . 8-kilobase AccI-EcoRI restriction fragment"],"gene_indices_start":[31,131],"gene_indices_end":[77,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1672,"text":"Alternatively processed isoforms of cellular nucleic acid-binding protein interact with a suppressor region of the human beta-myosin heavy chain gene .","gene":["cellular nucleic acid-binding protein","human beta-myosin heavy chain gene"],"gene_indices_start":[36,115],"gene_indices_end":[73,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1674,"text":"Thus , the predicted CD30v protein retains most of the cytoplasmic region , but lacks the extracellular and transmembrane domains .","gene":["CD30v protein"],"gene_indices_start":[21],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1675,"text":"To evaluate whether the human gene is also a target of thyroid hormone we have searched for T3-responsive elements in NRGN cloned genomic fragments spanning the whole gene .","gene":["NRGN","T3-responsive elements"],"gene_indices_start":[92,118],"gene_indices_end":[114,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1677,"text":"This work , therefore , also emphasizes the importance of careful choice of oligonucleotide and cDNA probes to study PKC zeta mRNA .","gene":["PKC zeta mRNA"],"gene_indices_start":[117],"gene_indices_end":[130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1679,"text":"The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants .","gene":["homeobox gene ATK1"],"gene_indices_start":[4],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1681,"text":"Since glutathione peroxidase ( GPX ) and superoxide dismutase ( SOD ) play a significant role in erythrocyte antioxidative defence , it is very important to determine their activity in occupationally exposed workers .","gene":["glutathione peroxidase","SOD","superoxide dismutase","GPX"],"gene_indices_start":[6,31,41,64],"gene_indices_end":[28,34,61,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1683,"text":"Like the consensus mammalian LHbeta gene , the 5'-flanking region of the gpLH \/ CGbeta gene contains a single TATA sequence 37 bp upstream of the translation start codon .","gene":["consensus mammalian LHbeta gene","gpLH \/ CGbeta gene"],"gene_indices_start":[9,73],"gene_indices_end":[40,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1686,"text":"Because the hcf109 locus was mapped at a distance < 0 . 1 centimorgans from the phytochrome C gene , its molecular characterization by positional cloning is possible .","gene":["hcf109 locus","phytochrome C gene"],"gene_indices_start":[12,80],"gene_indices_end":[24,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1688,"text":"However , by an NS35-specific RNA capture assay , the multimers were shown to possess the RNA-binding activity previously demonstrated for NS35 .","gene":["NS35-specific RNA","NS35"],"gene_indices_start":[16,139],"gene_indices_end":[33,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1689,"text":"This molecule , wH22xeGFP , consists of the entire humanized anti-FcgammaRI mAb H22 with eGFP genetically fused to the C-terminal end of each CH3 domain . wH22xeGFP binds within the ligand-binding region by its Fc end , as well as outside the ligand-binding region by its Fab ends , thereby cross-linking FcgammaRI .","gene":["FcgammaRI","H22","eGFP","entire humanized anti-FcgammaRI mAb","Fc","Fab","wH22xeGFP","wH22xeGFP","CH3 domain"],"gene_indices_start":[16,44,80,89,142,155,211,272,305],"gene_indices_end":[25,79,83,93,152,164,213,275,314],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1691,"text":"For example , introduction of immunogenic and purification tag sequences into the C-terminal coding region significantly decreased bop gene mRNA and protein accumulation .","gene":["bop gene mRNA"],"gene_indices_start":[131],"gene_indices_end":[144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1692,"text":"Together , these data suggest that the carboxyl terminus of CFTR contains a tyrosine-based internalization signal that interacts with the endocytic adaptor complex AP-2 to facilitate efficient entry of CFTR into clathrin-coated vesicles .","gene":["CFTR","AP-2","CFTR"],"gene_indices_start":[60,164,202],"gene_indices_end":[64,168,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1693,"text":"After treatment with tunicamycin , the transfectants secreted unglycosylated 18-kDa polypeptides which could also bind IgE .","gene":["IgE"],"gene_indices_start":[119],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1695,"text":"RNP1 , a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae .","gene":["RNP1"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1696,"text":"RESULTS : Basal plasma IGF-I levels as well as body mass index ( BMI ) were lower in amenorrheic patients than in healthy controls .","gene":["plasma IGF-I"],"gene_indices_start":[16],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1698,"text":"Polymerase chain reaction analysis of ETS1 cDNA identified several amplified products , indicating alternative splicing .","gene":["ETS1 cDNA"],"gene_indices_start":[38],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1699,"text":"Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity .","gene":["phosphatidylinositol 3-kinase","SH2-domain-containing proteins","Ras"],"gene_indices_start":[55,121,168],"gene_indices_end":[84,151,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1700,"text":"APC-resistance was determined with a functional method with high sensitivity and specificity for the factor V Leiden mutation .","gene":["factor V"],"gene_indices_start":[101],"gene_indices_end":[109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1701,"text":"The activity of the coat protein promoter of chloris striate mosaic virus is enhanced by its own and C1-C2 gene products .","gene":["C1-C2 gene products","coat protein promoter"],"gene_indices_start":[20,101],"gene_indices_end":[41,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1705,"text":"In the absence of other stabilizers , increased sucrose can provide increased thermoresistance to the virus in 2 . 5% albumin .","gene":["albumin"],"gene_indices_start":[118],"gene_indices_end":[125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1706,"text":"We found that lung cancer tissues of positive 67Ga scan expressed TFR , but those of a negative scan did not .","gene":["TFR"],"gene_indices_start":[66],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1707,"text":"The results of replicase assays performed with mutant VP2 containing a deletion in its RNA-binding domain suggests that the essential role for VP2 in replication is linked to the protein's ability to bind the mRNA template for minus-strand synthesis .","gene":["mutant VP2","VP2","replicase"],"gene_indices_start":[15,47,143],"gene_indices_end":[24,57,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1709,"text":"Recurrent arterial thrombotic disease on young onset and protein S deficiency .","gene":["protein S"],"gene_indices_start":[57],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1710,"text":"Three mutants ( pms1 , pms2 and pms3 ) isolated earlier from MW104-1B were shown to correct in vitro constructed plasmids with defined DNA mismatches ( G \/ T , A \/ C , G \/ G , etc . ) poorly ( Kramer et al . , 1989a ) .","gene":["pms1","pms3","pms2"],"gene_indices_start":[16,23,32],"gene_indices_end":[20,27,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1711,"text":"Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn .","gene":["G6PD"],"gene_indices_start":[26],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1712,"text":"The presence of locus-specific residues throughout the entire promoter region strongly suggests that the various HLA class I loci are differentially regulated .","gene":["HLA class I loci"],"gene_indices_start":[113],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1717,"text":"In mouse , Mmip1 ( Mad member interacting protein 1 ) and Smc3 share 99% sequence identity and are products of the same gene .","gene":["Mmip1","Mad member interacting protein 1","Smc3"],"gene_indices_start":[11,19,58],"gene_indices_end":[16,51,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1719,"text":"The variability is most likely a result of alternative splicing of exons from the primary elastin transcripts .","gene":["elastin transcripts"],"gene_indices_start":[90],"gene_indices_end":[109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1720,"text":"Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage .","gene":["desmoglein"],"gene_indices_start":[52],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1721,"text":"Analysis of the promoter sequence revealed the presence of a major transcriptional start site , a canonical TATA box and putative cis regulatory elements for pituitary specific expression as well as an E-responsive element .","gene":["E-responsive element"],"gene_indices_start":[202],"gene_indices_end":[222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1722,"text":"We previously showed that the upstream promoter element of the yeast RP39A gene consists of these identical sequence motifs .","gene":["upstream promoter element","yeast RP39A gene"],"gene_indices_start":[30,63],"gene_indices_end":[55,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1723,"text":"The roles of phorbol esters and cyclic AMP in mediating the GnRH response were also investigated .","gene":["GnRH"],"gene_indices_start":[60],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1727,"text":"The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive .","gene":["heat shock factor 1"],"gene_indices_start":[48],"gene_indices_end":[67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1728,"text":"Three new aromatase inhibitors have recently completed phase III evaluation as treatment of metastatic breast cancer in post-menopausal women whose disease has progressed despite tamoxifen therapy : anastrozole ( ARIMIDEX , Zeneca ) , letrozole ( FEMARA , Novartis ) and vorozole ( RIVIZOR , Janssen ) .","gene":["aromatase"],"gene_indices_start":[10],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1729,"text":"The recognition specificity of the p55 PDZ domain appears to be unique , since the three PDZ domains of hDlg ( human lymphocyte homologue of the Drosophila discs large tumor suppressor ) do not bind the cytoplasmic domain of glycophorin C .","gene":["PDZ domains","hDlg","p55","glycophorin C","Drosophila discs large tumor suppressor","PDZ domain"],"gene_indices_start":[35,39,89,104,145,225],"gene_indices_end":[38,49,100,108,184,238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1731,"text":"The Fas receptor mediates a signalling cascade resulting in programmed cell death ( apoptosis ) within hours of receptor cross-linking .","gene":["Fas receptor"],"gene_indices_start":[4],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1732,"text":"Moreover , it also discusses the effects of antihypertensive drugs currently regarded as first-choice agents , i . e . calcium antagonists and the angiotensin converting enzyme inhibitors , on intrarenal hemodynamics .","gene":["angiotensin converting enzyme"],"gene_indices_start":[147],"gene_indices_end":[176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1733,"text":"Regulation of laminin beta2 chain gene expression in human cancer cell lines .","gene":["laminin beta2 chain gene"],"gene_indices_start":[14],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1735,"text":"Effect of intraventricular administration of streptolysin O on the electroencephalogram of rabbits .","gene":["streptolysin O"],"gene_indices_start":[45],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1736,"text":"Thus , diamide treatment of nuclear extracts strongly reduces the binding of NFI proteins , and the addition of higher concentrations of dithiothreitol to nuclear extracts from TG-treated cells restores NFI-DNA binding to levels in extracts from untreated cells .","gene":["NFI proteins","NFI-DNA"],"gene_indices_start":[77,203],"gene_indices_end":[89,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1738,"text":"In these cells , E2 proteins had little or no stimulatory effect on the transcriptional activity of the HPV-11 enhancer-SV40 promoter .","gene":["HPV-11 enhancer-SV40 promoter","E2 proteins"],"gene_indices_start":[17,104],"gene_indices_end":[28,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1739,"text":"Constructs designed and expressed were E2L1 ( 1-98 ) , E2L1 . H1 ( 1-128 ) , E2L2 ( 120-233 ) , E2H1 . L2 ( 98-233 ) , and E2L1 . H1 . L2 ( 1-233 ) , where numbers in parentheses give the amino acid sequence for the portions of the E2 component incorporated into a construct .","gene":["E2L2 ( 120-233 )","E2L1 ( 1-98 )","E2","E2L1 . H1 ( 1-128 )","E2L1 . H1 . L2 ( 1-233 )","E2H1 . L2 ( 98-233 )"],"gene_indices_start":[39,55,77,96,123,232],"gene_indices_end":[52,74,93,116,147,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1741,"text":"Deglycosylation with endoglycosidase H showed that the mutant receptors had mainly high-mannose oligosaccharide chains .","gene":["endoglycosidase H"],"gene_indices_start":[21],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1745,"text":"This observation calls for careful monitoring of calcium and alkaline phosphatase values and possible adjustments of vitamin D intake when fortifiers are used for extended periods .","gene":["alkaline phosphatase"],"gene_indices_start":[61],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1746,"text":"Interference with rheumatoid factor was only observed in the ELISA enzygnost if sera were not pretreated with latex adsorbents .","gene":["rheumatoid factor"],"gene_indices_start":[18],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1748,"text":"Cardiac markers troponin T , CK-MB mass and myoglobin were helpful in the differential diagnosis of chest pain , even when the ECG was unremarkable or nonspecific .","gene":["CK-MB","troponin T","myoglobin"],"gene_indices_start":[16,29,44],"gene_indices_end":[26,34,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1749,"text":"We have determined that the mutants define two complementation groups , designated cgs1+ and cgs2+ ( continues to grow in stationary ) .","gene":["cgs1+","cgs2+"],"gene_indices_start":[83,93],"gene_indices_end":[88,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1750,"text":"The ectopic expression of Oct-3 \/ 4 in hybrid cells under a constitutive promoter is sufficient for transcriptional activation of an octamer-dependent promoter .","gene":["Oct-3 \/ 4"],"gene_indices_start":[26],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1751,"text":"The accumulation of both LHA4 and LHA2 mRNAs is induced by the addition of exogenous sugars and this induction appears to be dependent on sugar uptake and metabolism , because mannitol and 3-O-methylglucose do not stimulate mRNA accumulation .","gene":["LHA2 mRNAs","LHA4"],"gene_indices_start":[25,34],"gene_indices_end":[29,44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1752,"text":"A further study on plasminogen activator release by vasoactive agents in the isolated perfused dog leg .","gene":["plasminogen activator"],"gene_indices_start":[19],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1753,"text":"Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies : improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide .","gene":["serum IgM anti-GM1 antibodies"],"gene_indices_start":[51],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1754,"text":"Spfkh1 is transcribed in one open reading frame that contains the DNA binding domain , nuclear localization signal and transactivation domain .","gene":["Spfkh1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1755,"text":"Using appropriate synthetic HSE oligonucleotides , three types of clones with potential HSE binding domains were isolated from a tomato lambda gt11 expression library by DNA-ligand screening .","gene":["synthetic HSE oligonucleotides","HSE binding domains"],"gene_indices_start":[18,88],"gene_indices_end":[48,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1756,"text":"The presence of such a putative RNA- binding domain suggests a mechanism for the observed autoregulation of bacteriophage T4 DNA polymerase synthesis by binding to its own mRNA .","gene":["T4 DNA polymerase"],"gene_indices_start":[122],"gene_indices_end":[139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1757,"text":"Glutathione S-transferase ( GST ) -E2F and GST-DP fusion proteins were found to cooperate in binding to the three E2F sites in the DNA polymerase alpha gene promoter in vitro .","gene":["DNA polymerase alpha gene promoter","Glutathione S-transferase","-E2F","GST","GST-DP fusion proteins","E2F sites"],"gene_indices_start":[0,28,34,43,114,131],"gene_indices_end":[25,31,38,65,123,165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1759,"text":"Secondary cleavage of RT at Trp-595-Tyr-596 of Pol yields a truncated form lacking the C-terminal RNase H domain .","gene":["Trp-595-Tyr-596 of Pol","C-terminal RNase H domain","RT"],"gene_indices_start":[22,28,87],"gene_indices_end":[24,50,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1760,"text":"Although p48 gene induction is dependent on STAT1 and JAK1 , activated STAT1 does not bind to GATE .","gene":["STAT1","GATE","JAK1","p48 gene","STAT1"],"gene_indices_start":[9,44,54,71,94],"gene_indices_end":[17,49,58,76,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1762,"text":"In contrast , c-Src-derived construct ( a-Src ) , that was excluded from detergent-resistant membranes , could not restore the series of phagocytosis signaling .","gene":["c-Src-derived construct","a-Src"],"gene_indices_start":[14,40],"gene_indices_end":[37,45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1763,"text":"Ime1 plays a pivotal role in the initiation of meiosis in a \/ alpha diploid cells of Saccharomyces cerevisiae .","gene":["Ime1"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1765,"text":"To characterize this effect , we looked for targets of NS1 influenza virus protein among cellular translation factors .","gene":["NS1 influenza virus protein"],"gene_indices_start":[55],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1769,"text":"These data provide the molecular tools for the final identification of the MKS and the MUL genes .","gene":["MUL genes","MKS"],"gene_indices_start":[75,87],"gene_indices_end":[78,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1772,"text":"T-cell receptor beta ( TCR beta ) gene rearrangements occur in a third of early B-cell acute lymphoblastic leukemias ( ALLs ) .","gene":["TCR beta","T-cell receptor beta"],"gene_indices_start":[0,23],"gene_indices_end":[20,31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1773,"text":"This study assesses the feasibility and toxicity of adoptive immunotherapy with tumor infiltrating lymphocytes and recombinant interleukin-2 in 29 patients who underwent resection for stage III non-small-cell lung cancer .","gene":["recombinant interleukin-2"],"gene_indices_start":[115],"gene_indices_end":[140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1774,"text":"The MXR gene encodes a half-transporter and the absence of cytogenetic evidence of coamplification of other regions suggests that a partner may not be overexpressed , and instead the MXR half-transporter homodimerizes to mediate drug transport .","gene":["MXR half-transporter","MXR gene"],"gene_indices_start":[4,183],"gene_indices_end":[12,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1778,"text":"As the components of these complexes , at least five TRBPs ( p30 , p37 , p46 , p50 , and p56 ) showing specific binding to the TAR RNA were detected in the uv cross-linking assay .","gene":["p56","TAR RNA","p50","TRBPs","p30","p46","p37"],"gene_indices_start":[53,61,67,73,79,89,127],"gene_indices_end":[58,64,70,76,82,92,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1779,"text":"Acute stress in 7 rats also increased the mean amount of IL-6 released in the urine by 31 . 5% from 775 . 9 + \/ - 69 . 2 to 1 , 021 . 1 + \/ - 93 . 3 pg . \/ ml .","gene":["IL-6"],"gene_indices_start":[57],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1784,"text":"Here we demonstrate that native MRCK exists in high-molecular-weight complexes .","gene":["native MRCK"],"gene_indices_start":[25],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1785,"text":"In vitro binding studies demonstrate that eIF-5A is required for efficient interaction of Rev-NES with CRM1 \/ exportin1 and that eIF-5A interacts with the nucleoporins CAN \/ nup214 , nup153 , nup98 , and nup62 .","gene":["nup62","nup153","nup98","eIF-5A","CAN \/ nup214","Rev-NES","eIF-5A","CRM1 \/ exportin1"],"gene_indices_start":[42,90,103,129,168,183,192,204],"gene_indices_end":[48,97,119,135,180,189,197,209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1787,"text":"The thrombolytic effects of native tissue-type plasminogen activator ( AK-124 ) on experimental canine coronary thrombosis .","gene":["tissue-type plasminogen activator","AK-124"],"gene_indices_start":[35,71],"gene_indices_end":[68,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1788,"text":"Both immunophilins may have important roles in receptor assembly and may represent a new category of ligand- and calcium-dependent modulators of protein function .","gene":["immunophilins"],"gene_indices_start":[5],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1789,"text":"Substitutions of region I with synthetic sequences showed that no specific sequence but rather repeats of three or more consecutive adenines or thymines , without interruption by guanine or cytosine , are required for the ARS activity .","gene":["ARS"],"gene_indices_start":[222],"gene_indices_end":[225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1790,"text":"The coding region of 2385 nucleotides corresponds to a polypeptide chain of 795 amino acids , giving a molecular weight of 91 , 555 for the hsp108 protein .","gene":["hsp108 protein"],"gene_indices_start":[140],"gene_indices_end":[154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1792,"text":"Sequence analysis suggests that TtrA contains a molybdopterin guanine dinucleotide cofactor and a [ 4Fe-4S ] cluster , that TtrB binds four [ 4Fe-4S ] clusters , and that TtrC is an integral membrane protein containing a quinol oxidation site .","gene":["TtrA","TtrC","TtrB"],"gene_indices_start":[32,124,171],"gene_indices_end":[36,128,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1793,"text":"A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration .","gene":["beta2 integrin cytoplasmic domain"],"gene_indices_start":[39],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1794,"text":"The IE0 gene product also transactivated the IE1 promoter but did not affect expression from its own promoter .","gene":["IE1 promoter","IE0 gene"],"gene_indices_start":[4,45],"gene_indices_end":[12,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1798,"text":"The Arabidopsis FAD7 gene encodes a chloroplast omega-3 fatty acid desaturase that catalyzes the desaturation of lipid-linked dienoic fatty acids ( 18 : 2 and 16 : 2 ) .","gene":["Arabidopsis FAD7 gene","chloroplast omega-3 fatty acid desaturase"],"gene_indices_start":[4,36],"gene_indices_end":[25,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1799,"text":"Transient overexpression of c-Jun induced tenascin-C expression in primary REF and in FR3T3 , an established fibroblast cell line .","gene":["tenascin-C","c-Jun"],"gene_indices_start":[28,42],"gene_indices_end":[33,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1800,"text":"Dual roles of p82 , the clam CPEB homolog , in cytoplasmic polyadenylation and translational masking .","gene":["p82","CPEB homolog"],"gene_indices_start":[14,29],"gene_indices_end":[17,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1803,"text":"The recruitment of constitutively phosphorylated p185 ( neu ) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton .","gene":["growth factor","p185 ( neu )","neu"],"gene_indices_start":[49,56,260],"gene_indices_end":[53,59,273],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1805,"text":"The site-directed mutation of the kappa B motif in IL-6 \/ CAT plasmid resulted in the complete abrogation of IL-6 promoter activity in these cells .","gene":["IL-6 promoter","kappa B motif","IL-6 \/ CAT"],"gene_indices_start":[34,51,109],"gene_indices_end":[47,61,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1807,"text":"The mouse beta 2-syntrophin gene ( > 33 kilobases ) contains seven exons , all of which have homologues at the corresponding position in the alpha 1-syntrophin gene .","gene":["mouse beta 2-syntrophin gene","alpha 1-syntrophin gene"],"gene_indices_start":[4,141],"gene_indices_end":[32,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1809,"text":"In contrast to MPc3 , data indicate that the Pc protein M33 does not interact with AF9 .","gene":["AF9","MPc3","Pc protein","M33"],"gene_indices_start":[15,45,56,83],"gene_indices_end":[19,55,59,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1810,"text":"Expression of this protein in E . coli demonstrated that tyrosine was incorporated during suppression and that yeast cytoplasmic TyrRS activity was produced .","gene":["yeast cytoplasmic TyrRS"],"gene_indices_start":[111],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1811,"text":"Nucleotide sequence analysis of the Pseudomonas putida PpG7 salicylate hydroxylase gene ( nahG ) and its 3'-flanking region .","gene":["Pseudomonas putida PpG7 salicylate hydroxylase gene","nahG"],"gene_indices_start":[36,90],"gene_indices_end":[87,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1812,"text":"Taken together , our data suggest that PecS attenuates pelD and pelE expression rather than acting as a true repressor like KdgR .","gene":["pelE","PecS","pelD","KdgR"],"gene_indices_start":[39,55,64,124],"gene_indices_end":[43,59,68,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1813,"text":"In several cell lines , mTOR or its downstream targets can be regulated by phosphatidylinositol ( PI ) 3-kinase ; protein kinases A , B , and C ; heterotrimeric G-proteins ; a PD98059-sensitive kinase or calcium ; as well as by amino acids .","gene":["mTOR","kinase","protein kinases A , B , and C","phosphatidylinositol ( PI ) 3-kinase","heterotrimeric G-proteins"],"gene_indices_start":[24,75,114,146,194],"gene_indices_end":[28,111,143,171,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1814,"text":"Sequences downstream of the two human CA genes , possibly containing homologous enhancer elements , have not yet been reported .","gene":["human CA genes"],"gene_indices_start":[32],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1815,"text":"This establishes Rad3 \/ Mec1 as the only conserved protein which is required for all the DNA structure checkpoints in both yeast model systems .","gene":["Rad3","Mec1"],"gene_indices_start":[17,24],"gene_indices_end":[21,28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1816,"text":"However , plasmids carrying the yeast TyrRS gene could not be stably maintained in E . coli .","gene":["yeast TyrRS gene"],"gene_indices_start":[32],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1817,"text":"16 percent , P < 0 . 001 ) , and sustained normalization of serum alanine aminotransferase levels ( 41 percent vs .","gene":["serum alanine aminotransferase"],"gene_indices_start":[60],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1818,"text":"The sequence was determined of 6493 nucleotides encompassing the bet genes of Escherichia coli which encode the osmoregulatory choline-glycine betaine pathway .","gene":["choline-glycine betaine pathway","bet genes of Escherichia coli"],"gene_indices_start":[65,127],"gene_indices_end":[94,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1820,"text":"Based on the hypothesis that evolutionarily conserved regions are functionally important and likely to interact with coactivators , we compared the amino acid sequence of C \/ EBPalpha from different species ( frog to human ) and identified four highly conserved regions ( CR1-CR4 ) within the transactivation domain .","gene":["C \/ EBPalpha","CR1-CR4"],"gene_indices_start":[171,272],"gene_indices_end":[183,279],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1821,"text":"Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1 \/ Spc1 MAP kinase in fission yeast .","gene":["Sty1 \/ Spc1 MAP kinase"],"gene_indices_start":[81],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1826,"text":"Lipoprotein lipase ( LPL ) , a key enzyme in normal lipoprotein metabolism , has a complex pattern of regulation and tissue-specific expression .","gene":["Lipoprotein lipase","LPL"],"gene_indices_start":[0,21],"gene_indices_end":[18,24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1827,"text":"Protein electrophoresis showed decreased albumin levels in both groups , with lower values in G2 .","gene":["albumin"],"gene_indices_start":[41],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1828,"text":"A xylE transcriptional fusion to the putative mxbD promoter showed low-level expression in wild-type cells grown on one-carbon ( C1 ) compounds and no detectable expression in cells grown on succinate .","gene":["xylE transcriptional fusion","mxbD promoter"],"gene_indices_start":[2,46],"gene_indices_end":[29,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1830,"text":"The RNase MRP RNA gene was deleted by insertional replacement and found to be essential for cellular viability , indicating a critical nuclear role for RNase MRP .","gene":["RNase MRP","RNase MRP RNA gene"],"gene_indices_start":[4,152],"gene_indices_end":[22,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1832,"text":"A human Raf-responsive zinc-finger protein that binds to divergent sequences .","gene":["human Raf-responsive zinc-finger protein"],"gene_indices_start":[2],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1834,"text":"One of these small inteins might be inactive or a \"pseudo intein . \" The results suggest a modular architecture for inteins , clarify their origin and relationship to other protein families , and extend recent experimental findings on the functional roles of intein N , C , and EN motifs .","gene":["\"pseudo intein . \"","inteins","small inteins","intein N , C , and EN motifs"],"gene_indices_start":[13,50,116,259],"gene_indices_end":[26,68,123,287],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1836,"text":"As in S . cerevisiae , the sequence of rhp51+ showed two MluI cell-cycle boxes and a putative DNA damage-responsive element in its upstream region .","gene":["rhp51+","MluI cell-cycle boxes"],"gene_indices_start":[39,57],"gene_indices_end":[45,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1837,"text":"There was no competition between activin A and OP-1 for availability of Smad4 , indicating that the concentration of this common signal transducer is not limiting for generating the observed biological responses .","gene":["OP-1","activin A","Smad4"],"gene_indices_start":[33,47,72],"gene_indices_end":[42,51,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1841,"text":"Molecular cloning and functional characterization of murine sphingosine kinase .","gene":["murine sphingosine kinase"],"gene_indices_start":[53],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1842,"text":"Processing of the polycistronic precursor requires nucleases also involved in rRNA processing , i . e . , Rnt1p and Rat1p .","gene":["rRNA","nucleases","Rnt1p","Rat1p"],"gene_indices_start":[51,78,106,116],"gene_indices_end":[60,82,111,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1843,"text":"Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe .","gene":["Cdc2"],"gene_indices_start":[19],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1844,"text":"Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster : cloning , structure , and localization of the gene .","gene":["diazepam-binding inhibitor"],"gene_indices_start":[34],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1847,"text":"We purified a Ca2+ \/ calmodulin ( CaM ) -dependent protein kinase ( CaM kinase ) from the yeast Saccharomyces cerevisiae with properties similar to mammalian type II CaM kinases .","gene":["Ca2+ \/ calmodulin ( CaM ) -dependent protein kinase ( CaM kinase ) from the yeast Saccharomyces cerevisiae","mammalian type II CaM kinases"],"gene_indices_start":[14,148],"gene_indices_end":[120,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1848,"text":"The 247-kDa complex appears to contain two distinct protein-DNA complexes of approximately 232 and 256 kDa and represents two proteins covalently cross-linked to a single DRE oligonucleotide , while the 97 , 105 , and 115-kDa complexes represent single protein-DRE cross-links .","gene":["DRE","protein-DRE"],"gene_indices_start":[171,253],"gene_indices_end":[174,264],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1849,"text":"Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4 .","gene":["herpes simplex virus regulatory protein ICP4"],"gene_indices_start":[68],"gene_indices_end":[112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1850,"text":"In insects , arylalkylamine N-acetyltransferases ( AANATs ) have been implicated in several physiological processes , including sclerotization , inactivation of certain neurotransmitters , and , similar to the function in vertebrates , catalysis of the rate-limiting step in melatonin biosynthesis .","gene":["AANATs","arylalkylamine N-acetyltransferases"],"gene_indices_start":[13,51],"gene_indices_end":[48,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1854,"text":"ROS x SRC ( R ) contains a 16-amino-acid deletion that includes the 3' half of the transmembrane domain of ros .","gene":["ROS","SRC","ros","R"],"gene_indices_start":[0,6,12,107],"gene_indices_end":[3,9,13,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1857,"text":"We describe a novel zinc finger protein , dsRBP-ZFa , isolated by screening an expression library with dsRNA .","gene":["zinc finger protein","dsRBP-ZFa"],"gene_indices_start":[20,42],"gene_indices_end":[39,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1862,"text":"These results suggested that NfxB negatively autoregulates the expression of nfxB itself .","gene":["NfxB","nfxB"],"gene_indices_start":[29,77],"gene_indices_end":[33,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1863,"text":"An egg protein , lysozyme , is a still unlabeled additive currently used in cheese preparation .","gene":["lysozyme"],"gene_indices_start":[17],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1866,"text":"No direct repeats flank the pseudogene in the U2 \/ 4 locus .","gene":["U2 \/ 4 locus"],"gene_indices_start":[46],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1869,"text":"Pharmacologic doses of vitamin B6 administered to lactating women have been reported to suppress plasma prolactin .","gene":["plasma prolactin"],"gene_indices_start":[97],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1873,"text":"Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin .","gene":["human phosphoinositide 3-kinase","C2 domain"],"gene_indices_start":[13,52],"gene_indices_end":[44,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1876,"text":"However , inhibition of both the ERK \/ RSK and the p38 \/ MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation .","gene":["p38 \/ MAPKAP kinase 2","CREB","ERK \/ RSK"],"gene_indices_start":[33,51,115],"gene_indices_end":[42,72,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1878,"text":"Association with HL-A W-27 .","gene":["HL-A W-27"],"gene_indices_start":[17],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1879,"text":"Endonuclease III ( Nth ) of Escherichia coli is a DNA glycosylase essential for the removal of oxidised pyrimidine base residues from DNA .","gene":["DNA glycosylase","Nth","Endonuclease III"],"gene_indices_start":[0,19,50],"gene_indices_end":[16,22,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1880,"text":"This sequence , Thr-Gly-X-X-Gly-Asp-Gly-Lys-Ile-Phe , forms part of the B-loop and is conserved in a wide variety of organisms that include bacteria , algae and archeabacteria .","gene":["B-loop","Thr-Gly-X-X-Gly-Asp-Gly-Lys-Ile-Phe"],"gene_indices_start":[16,72],"gene_indices_end":[51,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1881,"text":"Hierarchy of protein tyrosine kinases in interleukin-2 ( IL-2 ) signaling : activation of syk depends on Jak3 ; however , neither Syk nor Lck is required for IL-2-mediated STAT activation .","gene":["STAT","protein tyrosine kinases","syk","Lck","Syk","Jak3","IL-2","interleukin-2"],"gene_indices_start":[13,41,57,90,105,130,138,172],"gene_indices_end":[37,54,61,93,109,133,141,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1882,"text":"Multifunctional protein kinase ( MFPK ) phosphorylates ATP-citrate lyase on peptide B on two sites , BT and BS , on threonine and serine , respectively , inhibitor 2 on a threonyl residue , and glycogen synthase at sites 2 and 3 .","gene":["inhibitor 2","peptide B","MFPK","glycogen synthase","ATP-citrate lyase","Multifunctional protein kinase"],"gene_indices_start":[0,33,55,76,154,194],"gene_indices_end":[30,37,72,85,165,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1883,"text":"Prrp can also associate with the EVH1 domain of Mena , another microfilament-associated protein .","gene":["Prrp","Mena","EVH1 domain"],"gene_indices_start":[0,33,48],"gene_indices_end":[4,44,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1884,"text":"The full length cDNA sequence of a Type I transforming growth factor-beta ( TGF-beta ) receptor has been isolated from the filarial parasitic nematode Brugia pahangi .","gene":["Type I transforming growth factor-beta ( TGF-beta ) receptor"],"gene_indices_start":[35],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1887,"text":"Furthermore , no transcripts of the same size and having the same developmental profile as those generated by the wild-type E10 fragment were identified by probes covering the remainder of the cloned region .","gene":["wild-type E10 fragment"],"gene_indices_start":[114],"gene_indices_end":[136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1890,"text":"Furthermore , a p21X protein lacking the N-terminus of Rex1 was expressed at high levels ; our data indicate that p21X is translated from the 1 . 6-kb mRNA which is derived primarily from deleted proviruses .","gene":["Rex1","p21X","p21X protein"],"gene_indices_start":[16,55,114],"gene_indices_end":[28,59,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1894,"text":"OBJECTIVE : To evaluate the relationship between blood flow in the tumor assessed by color Doppler ultrasound , microvessel density , and vascular endothelial growth factor levels in endometrial carcinoma .","gene":["vascular endothelial growth factor"],"gene_indices_start":[138],"gene_indices_end":[172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1897,"text":"To determine the function of VZV gK in virus growth , a series of gK deletion mutants were constructed with VZV cosmid DNA derived from the Oka strain .","gene":["VZV gK","gK deletion mutants"],"gene_indices_start":[29,66],"gene_indices_end":[35,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1899,"text":"Ectopic ACTH syndrome and medullary thyroid carcinoma .","gene":["ACTH"],"gene_indices_start":[8],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1900,"text":"We observed that dephosphorylation severely inhibits the DNA-binding ability of C \/ EBP-delta and its transactivating potential increases in the presence of cellular phosphatase inhibitors , such as okadaic acid and sodium orthovanadate .","gene":["phosphatase","C \/ EBP-delta"],"gene_indices_start":[80,166],"gene_indices_end":[93,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1901,"text":"Furthermore , phosphatidylinositol ( 3 , 4 , 5 ) trisphosphate specifically stimulates the activity of ILK in vitro , and in addition , membrane targetted constitutively active Pi ( 3 ) K activates ILK in vivo .","gene":["Pi ( 3 ) K","ILK","ILK"],"gene_indices_start":[103,177,198],"gene_indices_end":[106,187,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1904,"text":"Furthermore , our novel observation that expression of a highly activated FGFR3 kinase domain is able to morphologically transform fibroblasts suggests that dysregulation of FGFR3 has the potential to play a role in human neoplasia .","gene":["FGFR3","FGFR3 kinase domain"],"gene_indices_start":[74,174],"gene_indices_end":[93,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1906,"text":"C \/ EBP alpha also activates the promoter of the rat class-I ADH gene in a sequence-specific manner [ Potter et al . , Arch .","gene":["C \/ EBP alpha","rat class-I ADH gene"],"gene_indices_start":[0,49],"gene_indices_end":[13,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1908,"text":"XYL1 was isolated as a highly expressed fusion clone from a 'lacZ translational fusion library .","gene":["'lacZ","XYL1"],"gene_indices_start":[0,60],"gene_indices_end":[4,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1909,"text":"Only transcripts specific for TSGF-2 are detected in ovary and testes tissues of adults as well as in puparia , while neither gene is expressed during the larval developmental stages .","gene":["TSGF-2"],"gene_indices_start":[30],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1910,"text":"Using RACE techniques we have cloned and sequenced one of the hamster liver 3-hydroxy-hexobarbital dehydrogenases which catalyze not only cyclic alcohols but also 17beta-hydroxy-steroids and 3alpha-hydroxysteroids .","gene":["3-hydroxy-hexobarbital dehydrogenases"],"gene_indices_start":[76],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1911,"text":"Currently , the clinical use of 5-aminolaevulinic acid ( ALA ) induced protoporphyrin IX ( PPIX ) for photodynamic therapy ( PDT ) is limited by the maximum tolerated oral ALA dose ( 60 mg \/ kg ) .","gene":["protoporphyrin IX","PPIX"],"gene_indices_start":[71,91],"gene_indices_end":[88,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1912,"text":"The presence of an unusual transcript possessing IVS2C beta 1 at the 5' terminus suggests that cleavage of its splice acceptor is inefficient or negatively regulated .","gene":["IVS2C beta 1"],"gene_indices_start":[49],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1914,"text":"The altered amino acid residues of the seven mutant 9ORF1 polypeptides clustered within three separate regions referred to as region I ( residues 34 to 41 ) , region II ( residues 89 to 91 ) , and C-terminal region III ( residues 122 to 125 ) .","gene":["mutant 9ORF1 polypeptides"],"gene_indices_start":[45],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1915,"text":"A one base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity .","gene":["CYP3A4 gene"],"gene_indices_start":[64],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1916,"text":"The recombinant purified protein expressed in the baculovirus system had an approximate molecular size 20 kDa with amino-terminal sequence of AVQGP .","gene":["amino-terminal sequence of AVQGP"],"gene_indices_start":[115],"gene_indices_end":[147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1918,"text":"When overexpressed in an appropriate cell line , TAN-1C prevented kappa B-dependent transactivation in transient reporter gene assays in a fashion similar to the structurally related protein , Bcl-3 .","gene":["TAN-1C","Bcl-3"],"gene_indices_start":[49,193],"gene_indices_end":[55,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1919,"text":"Ras-GRF1 transiently expressed with v-Src was tyrosine-phosphorylated and showed significant GEF activity toward Rac , but not Rho and Cdc42 , which was comparable with that induced by Gbetagamma .","gene":["Rac","v-Src","Rho","GEF","Ras-GRF1","Gbetagamma","Cdc42"],"gene_indices_start":[0,36,93,113,127,135,185],"gene_indices_end":[8,41,96,116,130,140,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1921,"text":"The 5' flanking region of the CD1 gene contained the binding motifs for two cytokine-inducible transcription factors , NF-IL2-A and NF-IL6 .","gene":["NF-IL6","CD1 gene","NF-IL2-A"],"gene_indices_start":[30,119,132],"gene_indices_end":[38,127,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1924,"text":"Replacement of the CRE with a second copy of the AP-1 site results in a level of transcriptional activity comparable with that of the wild-type sequence , but replacement of the AP-1 site with a CRE abolishes activity .","gene":["AP-1 site","CRE","AP-1 site","CRE"],"gene_indices_start":[19,49,178,195],"gene_indices_end":[22,58,187,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1926,"text":"In mammals , the transcriptional repressors in the Wnt pathway are not well defined .","gene":["Wnt pathway"],"gene_indices_start":[51],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1930,"text":"Additional studies revealed that bovine brain Galpha ( q \/ 11 ) could also bind to an N-terminal construct of GRK2 , while no binding of Galpha ( q \/ 11 ) , Galpha ( s ) , Galpha ( i ) , or Galpha ( 12 \/ 13 ) to comparable constructs of GRK5 or GRK6 was observed .","gene":["GRK6","Galpha ( i )","Galpha ( s )","GRK5","bovine brain Galpha ( q \/ 11 )","GRK2","Galpha ( 12 \/ 13 )","Galpha ( q \/ 11 )"],"gene_indices_start":[33,110,137,157,172,190,237,245],"gene_indices_end":[63,114,154,169,184,208,241,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1931,"text":"Within this sequence the MSAS gene was identified as a 5322-bp-long open reading frame coding for a protein of 1774 amino acids and 190 , 731 Da molecular mass .","gene":["MSAS gene"],"gene_indices_start":[25],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1935,"text":"Initially , we observed that unmutated p53 is strongly expressed in premalignant mammary glands and in mammary tumors derived from the MMTV-c-myc strain .","gene":["p53"],"gene_indices_start":[39],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1937,"text":"The Dox-A2 ORF driven by the TDH3 promoter complemented the phenotype of a strain deleted for sun2 .","gene":["Dox-A2 ORF","sun2","TDH3 promoter"],"gene_indices_start":[4,29,94],"gene_indices_end":[14,42,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1941,"text":"We have isolated and functionally characterized the mouse gene for the C2 subunit of the 20S proteasome .","gene":["20S proteasome","C2 subunit"],"gene_indices_start":[71,89],"gene_indices_end":[81,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1943,"text":"A beta2 RARE reporter construct in which the methylation-susceptible cytosines in the sense strand were replaced by thymine displayed marked loss of activity in a replicated chromatin-dependent manner .","gene":["beta2 RARE reporter construct"],"gene_indices_start":[2],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1948,"text":"The predicted L mRNA was 6398 nucleotides long and contained a single open reading frame corresponding to an L protein encompassing 2109 amino acids with a MW of 241 , 546 .","gene":["L mRNA","L protein encompassing 2109 amino acids"],"gene_indices_start":[14,109],"gene_indices_end":[20,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1949,"text":"The kinetics of kinase activity within these complexes compared to CheA alone indicate approximately a 50% decrease in the KM for ATP and a 100-fold increase in the Vmax .","gene":["kinase","CheA"],"gene_indices_start":[16,67],"gene_indices_end":[22,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1950,"text":"Thyrotropin-induced expression of a gene for a ribosomal protein related to the trk oncogene .","gene":["trk oncogene"],"gene_indices_start":[80],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1951,"text":"Gap b3 consists of two polypeptide chains ( Mr = 110 , 000 and 30 , 000 ) , which seem to be proteolytic cleavage products connected by disulfide bonds from a precursor protein .","gene":["Gap b3"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1952,"text":"The observed sequence variation disrupts the first ORF in many Y's while most of the second ORF including the putative helicase region is unaffected .","gene":["helicase region","Y's"],"gene_indices_start":[63,119],"gene_indices_end":[66,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1953,"text":"Serum IgG was initially elevated in 6 patients .","gene":["IgG"],"gene_indices_start":[6],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1954,"text":"The cleavage site between VPg and RNA dependent RNA polymerase was predicted to be E445-T446 based on the amino acid sequence analysis of the polyprotein from different sobemoviruses .","gene":["VPg","RNA dependent RNA polymerase"],"gene_indices_start":[26,34],"gene_indices_end":[29,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1961,"text":"Furthermore , we showed that ERSF including NF-Y and ATF6alpha and \/ or beta and capable of binding to ERSE is indeed formed when the cellular UPR is activated .","gene":["ATF6alpha and \/ or beta","NF-Y","ERSE","UPR","ERSF"],"gene_indices_start":[29,44,53,103,143],"gene_indices_end":[33,48,76,107,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1963,"text":"The gene sequence also identified a 340-nucleotide RNA in total yeast RNA and in purified RNase MRP enzyme preparations .","gene":["RNase MRP enzyme"],"gene_indices_start":[90],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1965,"text":"The murine MHC class I genes , H-2Dq and H-2Lq , are strikingly homologous to each other , H-2Ld , and two genes reported to encode tumor-specific antigens .","gene":["H-2Lq","murine MHC class I genes","H-2Ld","tumor-specific antigens","H-2Dq"],"gene_indices_start":[4,31,41,91,132],"gene_indices_end":[28,36,46,96,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1968,"text":"To identify additional non-Sir factors that affect rDNA silencing , we performed a genetic screen designed to isolate mutations which alter the expression of reporter genes integrated within the rDNA .","gene":["non-Sir factors"],"gene_indices_start":[23],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1970,"text":"The first 85 nt upstream of the transcription initiation site of the mouse desmin gene , which contain an E box ( E1 ) , the binding site of the helix-loop-helix myogenic regulators , are sufficient to confer low level muscle-specific expression .","gene":["E1","mouse desmin gene"],"gene_indices_start":[69,114],"gene_indices_end":[86,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1971,"text":"The first involved complementation of a nonphotosynthetic mutant of Chlamydomonas , CC-2341 ( ac-u-g-2 . 3 ) , which has a frameshift mutation in the psaB gene , and selection of photosynthetic transformants on minimal medium .","gene":["psaB gene"],"gene_indices_start":[150],"gene_indices_end":[159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1972,"text":"Moreover , the second RCC1-like motif located at the amino-terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins , but not on other small GTP binding proteins such as Ran or R-Ras2 \/ TC21 .","gene":["R-Ras2","TC21","Ran","small GTP binding proteins","ARF1","RCC1-like motif","Rab proteins","p619"],"gene_indices_start":[22,71,118,153,185,220,227,236],"gene_indices_end":[37,75,122,165,211,223,233,240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1973,"text":"Subcloning of DNA fragments from the 8 . 5-kilobase ( kb ) insert of pAVO4 defined a 4-kb DNA fragment which contained the functional FBP+ gene and its regulatory region .","gene":["functional FBP+ gene"],"gene_indices_start":[123],"gene_indices_end":[143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1975,"text":"Bandshift experiments demonstrate that BmHR3A binds specifically to RORE ( Retinoic acid-related Orphan receptor Response Element ) -like sequences in the promoters of both genes , thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis .","gene":["BmHR3A","BmGATAbeta","ESP genes","BmHR3A","Retinoic acid-related Orphan receptor Response Element","RORE"],"gene_indices_start":[39,68,75,215,254,269],"gene_indices_end":[45,72,129,221,264,278],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1978,"text":"Gamma glutamyl transpeptidase ( GGTP ) activity in the seminal fluid .","gene":["GGTP","Gamma glutamyl transpeptidase"],"gene_indices_start":[0,32],"gene_indices_end":[29,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1980,"text":"The morphological effects of two snake venoms , N . naja and A . piscivorus , and of the Direct Lytic Factor and Phospholipase-A , compounds purified from N . naja crude venom , were investigated on lung and cremaster vessels of rats .","gene":["Phospholipase-A","Direct Lytic Factor"],"gene_indices_start":[89,113],"gene_indices_end":[108,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1981,"text":"The regional blockade of H1R was observed mainly in the frontal , temporal and anterior cingulate cortices , and the intravenous administration of d-chlorpheniramine as a therapeutic dose ( 2 mg ) blocked over 60% of H1R in the frontal cortices .","gene":["H1R","H1R"],"gene_indices_start":[25,217],"gene_indices_end":[28,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1982,"text":"The frequency of positive anti-GM1 antibody titers in the Guillain-Barre syndrome patients with PEN 19 isolates was higher than that in the Guillain-Barre syndrome and Fisher's syndrome patients without PEN 19 isolates .","gene":["anti-GM1 antibody"],"gene_indices_start":[26],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1984,"text":"We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene .","gene":["human EpoR gene"],"gene_indices_start":[159],"gene_indices_end":[174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1986,"text":"The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes .","gene":["immunoglobulin delta genes"],"gene_indices_start":[82],"gene_indices_end":[108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1987,"text":"Genomic and functional characterization of the oas gene family encoding O-acetylserine ( thiol ) lyases , enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana .","gene":["O-acetylserine ( thiol ) lyases","oas gene family"],"gene_indices_start":[47,72],"gene_indices_end":[62,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1993,"text":"The cDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97 . 6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein .","gene":["human ets-1 protein"],"gene_indices_start":[163],"gene_indices_end":[182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1994,"text":"Tetrad analysis and mitotic recombination experiments localized the PEP4 gene proximal to GAL4 on chromosome XVI .","gene":["GAL4","PEP4 gene"],"gene_indices_start":[68,90],"gene_indices_end":[77,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1997,"text":"Here we present evidence that major IE proteins IE86 , IE72 , and IE55 are capable of trans-activating the HIV LTR in a T-cell line , HUT-78 .","gene":["IE86","IE55","IE72","major IE proteins"],"gene_indices_start":[30,48,55,66],"gene_indices_end":[47,52,59,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1998,"text":"A phylogenetic analysis with the TK domains from these sequences and a fourth , from a novel scavenger RTK ( all domains comprise the signature for the TK class II receptors ) , showed that they are distantly related to the insulin and insulin-like receptors .","gene":["scavenger RTK","insulin-like receptors","TK domains","TK class II receptors","insulin"],"gene_indices_start":[33,93,152,224,236],"gene_indices_end":[43,106,173,231,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1999,"text":"Members of the myocyte-specific enhancer-binding factor 2 ( MEF2 ) family of transcription factors bind a conserved A \/ T-rich sequence in the control regions of numerous muscle-specific genes .","gene":["myocyte-specific enhancer-binding factor 2","MEF2"],"gene_indices_start":[15,60],"gene_indices_end":[57,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2000,"text":"We show that IL-6 activates JRE-IL6 through an H7-sensitive pathway that does not involve protein kinase C , cyclic AMP-dependent kinase , Ca ( 2+ ) - or calmodulin-dependent kinases , Ras , Raf-1 , or NF-IL6 ( C \/ EBP beta ) .","gene":["Raf-1","JRE-IL6","Ras","Ca ( 2+ ) - or calmodulin-dependent kinases","C \/ EBP beta","protein kinase C","NF-IL6","cyclic AMP-dependent kinase","IL-6"],"gene_indices_start":[13,28,90,109,139,185,191,202,211],"gene_indices_end":[17,35,106,136,182,188,196,208,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2002,"text":"Expression of the human papillomavirus type 11 E5A protein from the E1E4 , E5 transcript .","gene":["human papillomavirus type 11 E5A protein","E1E4 , E5 transcript"],"gene_indices_start":[18,68],"gene_indices_end":[58,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2004,"text":"The Jem peptide sequence shows a 'leucine-zipper' dimerisation motif with limited homology to Fos \/ Jun and ATF \/ CREB proteins and several putative phosphorylation sites .","gene":["ATF \/ CREB proteins","Fos \/ Jun","Jem"],"gene_indices_start":[4,94,108],"gene_indices_end":[7,103,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2005,"text":"We have utilized the human 4F2 heavy chain ( 4F2HC ) gene as a model system in studies designed to elucidate the molecular events involved in regulating inducible gene expression during normal human T-cell activation .","gene":["4F2HC","human 4F2 heavy chain"],"gene_indices_start":[21,45],"gene_indices_end":[42,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2006,"text":"We cloned the third human gene for the LD78 , termed LD78 gamma and the sequence analysis showed that it is a 5'-truncated pseudogene .","gene":["LD78","LD78 gamma"],"gene_indices_start":[39,53],"gene_indices_end":[43,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2007,"text":"Moreover , the reconstitution of eUSF and TFIID-depleted transcription complexes with purified protein fractions demonstrate that not only TFIID but also eUSF essentially participates in complex formation even on H5 promoter mutations lacking the TATA-box .","gene":["H5 promoter","eUSF","eUSF","TFIID"],"gene_indices_start":[33,139,154,213],"gene_indices_end":[37,144,158,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2009,"text":"BIAcore analysis gave a Kaff of 4 . 4 x 10 ( 10 ) M-1 for the binding of N-A3 to T84 . 1 and 2 . 2 x 10 ( 10 ) M-1 for the binding of N-A3 to T84 . 66 .","gene":["T84 . 66","N-A3","N-A3","T84 . 1"],"gene_indices_start":[73,81,134,142],"gene_indices_end":[77,88,138,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2010,"text":"Together these data imply that the HFV R region acts in the nucleus to modify the cytoplasmic fate of target HFV mRNA .","gene":["target HFV mRNA","HFV R region"],"gene_indices_start":[35,102],"gene_indices_end":[47,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2011,"text":"Transcription factor recognition surface on the RNA polymerase alpha subunit is involved in contact with the DNA enhancer element .","gene":["RNA polymerase alpha subunit"],"gene_indices_start":[48],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2013,"text":"Thus , transcriptional regulation , splicing , kinase interaction sites , and tyrosine phosphorylation of the LMP2A homologs have been conserved despite significant sequences heterogeneity in the preterminal repeat regions of these human and nonhuman primate EBVs .","gene":["LMP2A homologs"],"gene_indices_start":[110],"gene_indices_end":[124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2014,"text":"These results indicate the presence of TATA-unified transcription systems in contemporary eukaryotes and provide insight into the residual need for TBP by all three Pols in other eukaryotes despite a lack of TATA elements in their promoters .","gene":["TBP","Pols"],"gene_indices_start":[148,165],"gene_indices_end":[151,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2015,"text":"The Saccharomyces cerevisiae RAD30 gene , a homologue of Escherichia coli dinB and umuC , is DNA damage inducible and functions in a novel error-free postreplication repair mechanism .","gene":["homologue of Escherichia coli dinB","umuC","Saccharomyces cerevisiae RAD30 gene"],"gene_indices_start":[4,44,83],"gene_indices_end":[39,78,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2018,"text":"A limiting factor were disturbances in the system of energy transport ( creatine phosphate , creatine phosphokinase ) and of the calcium pump ( Ca++-ATPase of the sarcoplasmic reticulum , SPR ) , which evidently led to a decrease of the inotropic properties of the myocardium at 70% restriction of coronary blood flow .","gene":["Ca++-ATPase","creatine phosphokinase"],"gene_indices_start":[93,144],"gene_indices_end":[115,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2020,"text":"It is shown that the ( G+C ) -rich element of the aldolase C promoter directs transcription in neuronal as well as in nonneuronal cells .","gene":["aldolase C promoter"],"gene_indices_start":[50],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2021,"text":"During most of the cell cycle , separase is kept inactive by binding to an inhibitory protein called securin .","gene":["securin","separase"],"gene_indices_start":[32,101],"gene_indices_end":[40,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2022,"text":"A comparison of the nucleotide sequence of the p54 gene carried by two virulent ASFV strains ( E70 and E75 ) with that obtained from virus Ba71V showed 100% similarity .","gene":["p54 gene"],"gene_indices_start":[47],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2023,"text":"The human immunodeficiency virus type-1 ( HIV-1 ) Tat protein regulates transcription by stimulating RNA polymerase processivity .","gene":["RNA polymerase","human immunodeficiency virus type-1 ( HIV-1 ) Tat protein"],"gene_indices_start":[4,101],"gene_indices_end":[61,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2026,"text":"Cotransfection of the coactivator CREB-binding protein relieved the transcriptional repression of PPARalphawt by PPARalphatr , suggesting that the dominant negative effect of PPARalphatr might occur through competition for essential coactivators .","gene":["PPARalphatr","PPARalphatr","CREB-binding protein","PPARalphawt"],"gene_indices_start":[34,98,113,175],"gene_indices_end":[54,109,124,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2028,"text":"In contrast , exogenous PTHrP1-34 and 1-86 peptides did not significantly affect IL-8 production ; moreover , PTHrP-neutralizing antibodies did not inhibit the production of IL-8 by transfected PTHrP .","gene":["IL-8","PTHrP","PTHrP-neutralizing antibodies","exogenous PTHrP1-34 and 1-86 peptides","IL-8"],"gene_indices_start":[14,81,110,174,194],"gene_indices_end":[51,85,139,178,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2032,"text":"Although the terminase apparently interacts with this gp20 portal peptide , polyclonal antibody against the portal peptide appears unable to access it in the native structure , suggesting intimate association of gp20 and gp17 possibly internalizes terminase regions within the portal in the packasome complex .","gene":["terminase","gp17","gp20","gp20 portal peptide","terminase regions"],"gene_indices_start":[13,54,212,221,248],"gene_indices_end":[22,73,216,225,265],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2035,"text":"The m7GpppN cap structure of eukaryotic mRNA is formed cotranscriptionally by the sequential action of three enzymes : RNA triphosphatase , RNA guanylyltransferase , and RNA ( guanine-7 ) -methyltransferase .","gene":["RNA ( guanine-7 ) -methyltransferase","RNA guanylyltransferase","RNA triphosphatase"],"gene_indices_start":[119,140,170],"gene_indices_end":[137,163,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2037,"text":"In addition , two-dimensional nuclear magnetic resonance studies with F17A , K13Q , F15Y and F27Y revealed that the mutants have the same overall structure as the wild-type CspB protein .","gene":["wild-type CspB protein"],"gene_indices_start":[163],"gene_indices_end":[185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2039,"text":"The plexiform neurofibroma and multiple localized neurofibromas are characteristic of NF1 .","gene":["NF1"],"gene_indices_start":[86],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2040,"text":"In addition , we find that E2F-1 can cause apoptosis in p53- \/ - tumour cells and further p300 , which also functions as a co-activator for the E2F \/ DP heterodimer , enhances the apoptotic activity of E2F-1 .","gene":["p300","p53- \/ -","E2F \/ DP heterodimer","E2F-1","E2F-1"],"gene_indices_start":[27,56,90,144,202],"gene_indices_end":[32,64,94,164,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2042,"text":"Here we report that the proline-rich region of CAP is recognized by the SH3 domains of several proteins , including the yeast actin-associated protein Abp1p .","gene":["SH3 domains","CAP","yeast actin-associated protein Abp1p"],"gene_indices_start":[47,72,120],"gene_indices_end":[50,83,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2043,"text":"Molecular cloning of a P-type ATPase gene from the cyanobacterium Synechocystis sp .","gene":["P-type ATPase gene"],"gene_indices_start":[23],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2045,"text":"In the work reported here , we used peptide mapping , mass spectrometry , and site-directed mutagenesis to identify two sets of pAP phosphorylation sites .","gene":["pAP"],"gene_indices_start":[128],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2046,"text":"The RAT3 gene encodes an 1157-amino acid protein without similarity to other known proteins .","gene":["RAT3 gene"],"gene_indices_start":[4],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2049,"text":"This is predicted to encode a 315-residue protein containing seven hydrophobic helical regions and a 17 amino acid motif characteristic of the R7G family of G-protein coupled membrane-bound receptors .","gene":["G-protein coupled membrane-bound receptors","R7G family"],"gene_indices_start":[143,157],"gene_indices_end":[153,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2052,"text":"The PI3K_68D cDNA encodes a protein of 210 kDa , which lacks sequences implicated in linking p110 PI 3-kinases to p85 adaptor proteins , but contains an amino-terminal proline-rich sequence , which could bind to SH3 domains , and a carboxy-terminal C2 domain .","gene":["PI 3-kinases","PI3K_68D cDNA","SH3 domains","p85 adaptor proteins"],"gene_indices_start":[4,98,114,212],"gene_indices_end":[17,110,134,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2053,"text":"Two mutations that affect larval cuticle protein gene expression in the 2 \/ 3 variant Drosophila melanogaster strain were investigated .","gene":["larval cuticle protein gene"],"gene_indices_start":[26],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2057,"text":"We show that the Sm-binding site and stem-loop III structures are necessary for correct 3'-end formation .","gene":["Sm-binding site"],"gene_indices_start":[17],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2058,"text":"Relief from autoinhibition and a subsequent 10-60-fold increase in V ( max ) have been observed upon N-SH2 domain engagement by a specific phosphotyrosyl ligand or upon deletion of the SH2 domains to yield the catalytic PTPase domain .","gene":["N-SH2 domain","SH2 domains","PTPase domain"],"gene_indices_start":[101,185,220],"gene_indices_end":[113,196,233],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2059,"text":"Viral cell-to-cell movement of PVX CP mutant was complemented in Nicotiana tabacum cv .","gene":["PVX CP mutant"],"gene_indices_start":[31],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2065,"text":"The in vitro activity of mecillinam and amoxicillin \/ clavulanic acid against Escherichia coli strains producing beta-lactamases of the TEM-1 , Oxa-1 and chromosomal type were studied using the broth and agar dilution technique .","gene":["TEM-1","beta-lactamases","Oxa-1"],"gene_indices_start":[113,136,144],"gene_indices_end":[128,141,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2066,"text":"The cop region also harbors a region of plasmid incompatibility , inc , encompassing a stem-loop structure , the repA promoter , Prep , as well as two distinct RepA binding sites , BD-1 and BD-2 .","gene":["inc","Prep","cop region","BD-2","RepA binding sites","repA promoter","BD-1"],"gene_indices_start":[4,66,113,129,160,181,190],"gene_indices_end":[14,69,126,133,178,185,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2067,"text":"IL-12 production was correlated with C3a concentration measured at the outlet of hemodialyzer after 15 min of dialysis ( r = 0 . 69 , P < 0 . 01 ) .","gene":["IL-12"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2069,"text":"DNA sequence analysis reveals that the gene encodes a protein highly homologous to rat CRP1 .","gene":["rat CRP1"],"gene_indices_start":[83],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2071,"text":"Recombinant expression of a chimeric EGFR \/ ErbB-3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB-3 signal transduction upon ligand activation .","gene":["EGFR \/ ErbB-3 receptor","ErbB-3"],"gene_indices_start":[37,144],"gene_indices_end":[59,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2072,"text":"Replicating simian virus 40 ( SV40 ) chromosomes were found to be similar to other eukaryotic chromosomes in that the rate and extent of micrococcal nuclease ( MNase ) digestion were greater with replicating than with nonreplicating mature SV40 chromatin .","gene":["MNase","micrococcal nuclease"],"gene_indices_start":[137,160],"gene_indices_end":[157,165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2077,"text":"The results of these studies support a model in which VirB4 dimers or homomultimers contribute structural information for the assembly of a transenvelope channel competent for bidirectional DNA transfer , whereas an ATP-dependent activity is required for configuring this channel as a dedicated export machine .","gene":["VirB4 dimers"],"gene_indices_start":[54],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2078,"text":"The C-terminal Cdk2 truncations , however , were non-functional in these strains and thus dependent for activity on the pho85 coding region which remained in the mutant pho85 : : HIS3 chromosomal locus .","gene":["HIS3 chromosomal locus","C-terminal Cdk2","mutant pho85","pho85 coding region"],"gene_indices_start":[4,120,162,179],"gene_indices_end":[19,139,174,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2081,"text":"Histochemical localization of GUS revealed promoter function in leaf epidermis , mesophyll and vascular bundles , in the cortex and vascular cylinder of the root .","gene":["GUS"],"gene_indices_start":[30],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2082,"text":"We show here that the in vitro transcription extract contains a binding activity that is specific for the initiator element and thus may participate in recruiting RNA polymerase II to the SL RNA gene promoter .","gene":["SL RNA gene promoter","RNA polymerase II"],"gene_indices_start":[163,188],"gene_indices_end":[180,208],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2086,"text":"The growth defect of a reg1 reg2 double mutant is alleviated by a loss-of-function mutation in the SNF1-encoded protein kinase .","gene":["reg2 double mutant","reg1","SNF1-encoded protein kinase"],"gene_indices_start":[23,28,99],"gene_indices_end":[27,46,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2087,"text":"When combined with serum ferritin and hemoglobin determinations , the serum transferrin receptor assay is a valuable addition in epidemiologic surveys because it provides a quantitative measure of functional iron deficiency and it distinguishes true IDA from the anemia of chronic disease .","gene":["transferrin receptor","hemoglobin","ferritin"],"gene_indices_start":[25,38,76],"gene_indices_end":[33,48,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2089,"text":"In this study , to characterize the gene for protein Z , its organization and structure were determined by a combination of PCR amplification of leukocyte DNA and isolation of phage clones from a human genomic library .","gene":["protein Z"],"gene_indices_start":[45],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2090,"text":"A genomic DNA clone encoding oryzacystatin ( Oc ) , a cysteine proteinase inhibitor ( cystatin ) of rice , was isolated from a lambda EMBL3 phage library constructed with Sau3AI partial digests of rice chromosomal DNA , by screening with an oc cDNA as a probe .","gene":["cysteine proteinase inhibitor","Oc","Sau3AI","cystatin","oryzacystatin","oc cDNA"],"gene_indices_start":[29,45,54,86,171,241],"gene_indices_end":[42,47,83,94,177,248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2091,"text":"Surprisingly , the RXR-specific ligand 9-cis-retinoic acid induced binding of SRC-1 to the RXR component of the TRE-bound heterodimer .","gene":["RXR component","SRC-1"],"gene_indices_start":[78,91],"gene_indices_end":[83,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2094,"text":"When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA , both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed .","gene":["plakoglobin","plakoglobin RNA","desmoglein"],"gene_indices_start":[37,68,142],"gene_indices_end":[47,83,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2095,"text":"Two related cDNAs were isolated that encode proteins that recognize the XMyoDa TATA motif .","gene":["XMyoDa TATA motif"],"gene_indices_start":[72],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2097,"text":"Expression from this element is regulated by a heteromeric protein complex containing ubiquitous ( i . e . the E2A- and HEB-encoded proteins ) and islet-enriched members of the bHLH family .","gene":["bHLH family","HEB-encoded proteins","E2A-"],"gene_indices_start":[111,120,177],"gene_indices_end":[115,140,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2099,"text":"The amplification was achieved using two primers which correspond to TRH progenitor sequence ( Lys \/ Arg-Arg-Gln-His-Pro-Gly-Lys \/ Arg-Arg ) .","gene":["TRH progenitor sequence","Lys \/ Arg-Arg-Gln-His-Pro-Gly-Lys \/ Arg-Arg"],"gene_indices_start":[69,95],"gene_indices_end":[92,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2101,"text":"The well-known Rel \/ NF-kappaB family of vertebrate transcription factors comprises a number of structurally related , interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location .","gene":["Rel \/ NF-kappaB family"],"gene_indices_start":[15],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2103,"text":"Tristetraprolin ( TTP ) is the prototype of a group of potential transcription factors that contain two or more unusual CCCH zinc fingers .","gene":["Tristetraprolin","TTP"],"gene_indices_start":[0,18],"gene_indices_end":[15,21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2104,"text":"These intron chimeras show that peripheral sequences and the elements that define the splice sites are adequate for self-splicing activity but that the central portions containing the catalytic cores of ai4 and bi4 are deficient ; these cores are the likely targets of the splicing proteins .","gene":["bi4","ai4"],"gene_indices_start":[203,211],"gene_indices_end":[206,214],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2105,"text":"Km and Vmax for two substrates , src-related peptide and poly ( Glu , Tyr ) ( 4 : 1 ) , were 2 . 4 mM and 2 . 5 mumol min-1 mg-1 and 0 . 26 mM and 1 . 2 mumol min-1 mg-1 , respectively .","gene":["src-related peptide"],"gene_indices_start":[33],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2106,"text":"Human ULK1 , a novel serine \/ threonine kinase related to UNC-51 kinase of Caenorhabditis elegans : cDNA cloning , expression , and chromosomal assignment .","gene":["serine \/ threonine kinase","UNC-51 kinase","Human ULK1"],"gene_indices_start":[0,21,58],"gene_indices_end":[10,46,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2108,"text":"High plasma concentrations of soluble E-selectin were closely associated with multiple-organ dysfunction and death .","gene":["E-selectin"],"gene_indices_start":[38],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2109,"text":"In such a manner , activated PKR inhibits cell growth and induces apoptosis , whereas disruption of normal PKR signaling results in unregulated cell growth .","gene":["PKR","PKR"],"gene_indices_start":[29,107],"gene_indices_end":[32,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2113,"text":"Anti-nucleolin mAb was used to confirm the antigenic properties of this p95 component .","gene":["Anti-nucleolin mAb","p95 component"],"gene_indices_start":[0,72],"gene_indices_end":[18,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2117,"text":"Because the mutant defective in DNA binding also fails to stimulate Abf1 ARS1 DNA-binding activity , our results suggest that Cdc6 DNA-binding activity may play a pivotal role in the initiation of DNA replication .","gene":["ARS1","Cdc6","Abf1"],"gene_indices_start":[68,73,126],"gene_indices_end":[72,77,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2118,"text":"Transcriptional regulation of the vacuolar H ( + ) -ATPase B2 subunit gene in differentiating THP-1 cells .","gene":["vacuolar H ( + ) -ATPase B2 subunit gene"],"gene_indices_start":[34],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2123,"text":"These results indicate that HIV-1 Gag sequences can influence the viral PR-mediated processing of the MuLV TM Env protein p15 ( E ) .","gene":["TM Env protein","p15 ( E )","Gag sequences"],"gene_indices_start":[34,107,122],"gene_indices_end":[47,121,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2124,"text":"Consistent with its role in p53 ubiquitination , mE6-AP was found both in the nucleus and cytosol , while Nedd-4 was found only in the cytosol .","gene":["Nedd-4","mE6-AP","p53"],"gene_indices_start":[28,49,106],"gene_indices_end":[31,55,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2126,"text":"When expressed alone in test cells , Atr-I is unable to bind TGF-beta , activin , or bone morphogenetic protein 2 .","gene":["TGF-beta","Atr-I","activin","bone morphogenetic protein 2"],"gene_indices_start":[37,61,72,85],"gene_indices_end":[42,69,79,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2127,"text":"One of these elements , the homeodomain-binding element , was identified to mediate negative regulation .","gene":["homeodomain-binding element"],"gene_indices_start":[28],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2128,"text":"The mutations did not affect the repression of CPA1 by arginine .","gene":["CPA1"],"gene_indices_start":[47],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2131,"text":"Anti-hepatitis A virus ( HAV ) titer after vaccination was measured in 83 HIV-positive and 39 HIV-negative men .","gene":["Anti-hepatitis A"],"gene_indices_start":[0],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2134,"text":"RNase protection analysis of two rRNA fragments whose genes are adjacent provided evidence for a polycistronic transcript containing sequences from both , as well as separate small RNAs .","gene":["rRNA fragments","RNase"],"gene_indices_start":[0,33],"gene_indices_end":[5,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2142,"text":"To compare the PAX3 and putative PAX3-FKHR transactivation domains , we fused C-terminal test fragments to the heterologous GAL4 DNA-binding domain and tested activation of a reporter gene co-transfected into four cell types .","gene":["GAL4 DNA-binding domain","PAX3","PAX3-FKHR transactivation domains"],"gene_indices_start":[15,33,124],"gene_indices_end":[19,66,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2143,"text":"A single amino acid change in the CPY vacuolar sorting signal prevents this interaction .","gene":["CPY vacuolar sorting signal"],"gene_indices_start":[34],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2145,"text":"The phosphotransferase system ( PTS ) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH .","gene":["HPr","ptsH","phosphotransferase","histidine phosphocarrier protein"],"gene_indices_start":[4,110,143,167],"gene_indices_end":[22,142,146,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2146,"text":"One member of this family , RFX1 , is a transcription factor for a variety of viral and cellular genes .","gene":["RFX1"],"gene_indices_start":[28],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2154,"text":"The rat aldolase C gene encodes a glycolytic enzyme strongly expressed in adult brain .","gene":["rat aldolase C gene"],"gene_indices_start":[4],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2155,"text":"The human cDNA clone NFBD1 ( previously designated KIAA0170 ) encodes a novel protein ( 2089 amino acids in length ; calculated molecular mass 226 , 440 D ) with possible BRCT domains at its carboxy terminus ( amino acid residues 1894-2089 ) .","gene":["BRCT domains"],"gene_indices_start":[171],"gene_indices_end":[183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2157,"text":"Mechanism of interferon action : identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene .","gene":["interferon","15-base-pair KCS element","RNA-dependent protein kinase pkr gene"],"gene_indices_start":[13,88,160],"gene_indices_end":[23,112,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2160,"text":"Finally , three new missense mutations , E138V , R254G , and P362R , were identified in the human AC gene from FD patients .","gene":["R254G","E138V","human AC gene","P362R"],"gene_indices_start":[41,49,61,92],"gene_indices_end":[46,54,66,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2164,"text":"Nuclease probing and structure-directed mutagenesis revealed that the 105-nt TE ( TE105 ) forms a cruciform secondary structure containing four helices connected by single-stranded regions .","gene":["TE105","105-nt TE","Nuclease"],"gene_indices_start":[0,70,82],"gene_indices_end":[8,79,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2165,"text":"These results suggested that the GG motifs contributed to the cell-specific transcription of the human insulin gene in association with the binding of the sequence-specific nuclear factor .","gene":["human insulin gene"],"gene_indices_start":[97],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2166,"text":"To investigate the potential role of SP1 , we examined nuclear extracts from HCMV-infected cells .","gene":["SP1"],"gene_indices_start":[37],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2167,"text":"In contrast , the differentiation of neoplastically transformed cells does not repress mitogenic responsiveness or junB or c-fos inducibility .","gene":["c-fos","junB"],"gene_indices_start":[115,123],"gene_indices_end":[119,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2169,"text":"Here , we report that swa5-1 is a new temperature-sensitive allele of the clathrin heavy chain gene ( chc1-5 ) , which carries a frameshift mutation near the 3' end of the CHC1 open reading frame .","gene":["CHC1","chc1-5","clathrin heavy chain gene","swa5-1"],"gene_indices_start":[22,74,102,172],"gene_indices_end":[28,99,108,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2173,"text":"The 5'-flanking region , from nucleotide -837 to -336 , contains TATA and inverted CAAT boxes as well as GATA-1 \/ SP1 erythroid-specific cis-acting regulatory elements .","gene":["GATA-1","SP1"],"gene_indices_start":[105,114],"gene_indices_end":[111,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2174,"text":"Mutation of KRKR to NGER retains MO15 in the cytoplasmic compartment , whilst the wild-type protein is detected exclusively in the nucleus .","gene":["NGER","KRKR","MO15"],"gene_indices_start":[12,20,33],"gene_indices_end":[16,24,37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2178,"text":"Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements .","gene":["serum response elements","serum response factor"],"gene_indices_start":[60,100],"gene_indices_end":[81,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2181,"text":"A rather similar pattern of results was obtained with respect to LMP2B mRNA expression , such transcripts being detectable only in a subset of tumors , and then at apparently low levels .","gene":["LMP2B mRNA"],"gene_indices_start":[65],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2183,"text":"To dissect these mechanisms , wild-type and mutant Raf-1 proteins were studied in an in vitro system with purified plasma membranes from v-Ras- and v-Src-transformed cells ( transformed membranes ) .","gene":["mutant Raf-1 proteins"],"gene_indices_start":[44],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2184,"text":"The influence of p53 on cytokine-triggered Janus kinase-STAT signaling was investigated in human hepatoma Hep3B cell lines engineered to constitutively express the temperature-sensitive Val135 mutant of p53 .","gene":["Janus kinase-STAT","Val135 mutant of p53","p53"],"gene_indices_start":[17,43,186],"gene_indices_end":[20,60,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2188,"text":"Vascular endothelial growth factor ( VEGF ) , a potent agonist secreted by virtually all cells , controls migration and division of vascular endothelial cells .","gene":["Vascular endothelial growth factor","VEGF"],"gene_indices_start":[0,37],"gene_indices_end":[34,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2191,"text":"A third prominent component of apparent molecular mass 16 kDa displayed several properties , including ability to bind 45Ca2+ , that are characteristic of the regulatory ( B ) subunit of mammalian calcineurin and was recognized by an antiserum raised against bovine calcineurin .","gene":["bovine calcineurin","mammalian calcineurin"],"gene_indices_start":[187,259],"gene_indices_end":[208,277],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2193,"text":"Change in plasma cystyl aminopeptidase ( oxytocinase ) between 30-34 weeks' gestation as a predictor of pregnancy-induced hypertension .","gene":["plasma cystyl aminopeptidase","oxytocinase"],"gene_indices_start":[10,41],"gene_indices_end":[38,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2196,"text":"Letter : Aryl hydrocarbon hydroxylase and smoking .","gene":["Aryl hydrocarbon hydroxylase"],"gene_indices_start":[9],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2198,"text":"Serial followup strength data for 2 patients were compared to change in creatinine kinase ( CK ) levels .","gene":["CK","creatinine kinase"],"gene_indices_start":[72,92],"gene_indices_end":[89,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2199,"text":"On the other hand , forced overexpression of the wild type , but not the kinase-inactivated mutant of nm23H1 , converted the GDP-bound forms of Rac1 , Cdc42 , and RhoA to their GTP-bound forms in vitro by its nucleoside diphosphate kinase activity , but nm23H1 alone apparently did not produce the GTP-bound form of these GTPases in vivo .","gene":["Rac1","nucleoside diphosphate kinase","Cdc42","nm23H1","GTPases","RhoA","nm23H1"],"gene_indices_start":[102,144,151,163,209,254,322],"gene_indices_end":[108,148,156,167,238,260,329],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2200,"text":"Mobility and supershift assays demonstrated that upstream stimulatory factor ( USF ) and Sp1 bind to the former elements and competition experiments confirmed that CREB \/ ATF and AP-1 bind to the CRE \/ TRE element .","gene":["CREB","ATF","CRE","TRE","AP-1","Sp1","upstream stimulatory factor","USF"],"gene_indices_start":[49,79,89,164,171,179,196,202],"gene_indices_end":[76,82,92,168,174,183,199,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2203,"text":"Growth factor stimulation of cells causes the phosphorylation of the c-Myc transcriptional activation domain at Ser62 within a proline-rich region that is highly conserved among members of the Myc family ( Alvarez , E . , Northwood , I . C . , Gonzalez , F .","gene":["Growth factor","Myc family","c-Myc transcriptional activation domain"],"gene_indices_start":[0,69,193],"gene_indices_end":[13,108,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2204,"text":"In this report this technique was applied to human breast carcinoma MDA-MB231 cells overexpressing human MPG in order to assess whether up-regulation of the initial step in BER alters the activity of selected other BER ( hOGG1 and APE \/ ref-1 ) or direct reversal ( MGMT ) repair activities .","gene":["human MPG","APE \/ ref-1","MGMT","hOGG1"],"gene_indices_start":[99,221,231,266],"gene_indices_end":[108,226,242,270],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2206,"text":"Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter .","gene":["SV40 early or late gene promoter"],"gene_indices_start":[98],"gene_indices_end":[130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2209,"text":"A substantial fraction of Cbl was constitutively associated with Grb2 and this interaction was mediated by Grb2 SH3 domains .","gene":["Grb2","Grb2 SH3 domains","Cbl"],"gene_indices_start":[26,65,107],"gene_indices_end":[29,69,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2210,"text":"The AGM and NIH \/ Swiss mouse CCR5 proteins are 97 . 7 to 98 . 3% and 79 . 8% identical to the human protein , respectively .","gene":["AGM and NIH \/ Swiss mouse CCR5 proteins"],"gene_indices_start":[4],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2211,"text":"Mutagenesis of the CDE \/ CHR elements and Sp1 sites in this region , alone or in combination , reduced transcriptional activity by 40-60% in asynchronously growing cells and abolished cell cycle periodicity in G2-M-synchronized cells .","gene":["Sp1 sites","CDE \/ CHR elements"],"gene_indices_start":[19,42],"gene_indices_end":[37,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2212,"text":"All our patients had polyps , 23 ( 54% ) had asthma , 12 ( 27% ) had aspirin sensitivity , 20 ( 65% ) had eosinophilia , and 9 ( 69% ) had increased total IgE levels .","gene":["IgE"],"gene_indices_start":[155],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2213,"text":"Differential activation of the extracellular signal-regulated kinase , Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi's sarcoma cells .","gene":["Janus kinase-Stat","basic fibroblast growth factor","Jun kinase","extracellular signal-regulated kinase"],"gene_indices_start":[31,71,86,133],"gene_indices_end":[68,81,103,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2214,"text":"By contrast , PvirE or Plac promoter constructs yielded functional VirE2 only if virE1 was coexpressed with virE2 .","gene":["virE2","virE1","PvirE","Plac promoter constructs","VirE2"],"gene_indices_start":[14,23,67,81,108],"gene_indices_end":[19,47,72,86,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2216,"text":"Normal alpha1 ( I ) collagen mRNA showed no significant reduction when AR or IR was expressed from the pHbetaAPr-1-neo vector and a small ( 10-20% ) but significant reduction when either ribozyme was expressed from the pCI . neo vector .","gene":["alpha1 ( I ) collagen mRNA","ribozyme"],"gene_indices_start":[7,187],"gene_indices_end":[33,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2219,"text":"Transformed cell lines expressing solely E1a or E1a and E1b gene products derived from these viruses display enhanced anchorage-independent growth at 37 degrees C versus 32 degrees C and display a cytoskeletal architecture resembling untransformed fibroblastic CREF cells .","gene":["E1a","E1a","E1b gene products"],"gene_indices_start":[41,48,56],"gene_indices_end":[44,51,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2220,"text":"The amino acid sequence of the S . aureus peptide carrying the phosphoryl group was found to be Gln-Val-Val-Ser-Thr-Phe-Met-Gly-Asn-Gly-Leu-Ala-Ile-Pro-His-Gly-Thr-Asp- Asp .","gene":["Gln-Val-Val-Ser-Thr-Phe-Met-Gly-Asn-Gly-Leu-Ala-Ile-Pro-His-Gly-Thr-Asp- Asp"],"gene_indices_start":[96],"gene_indices_end":[172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2221,"text":"PKC-gamma , which is not present in keratinocytes , also induces involucrin gene expression in a TPA-independent manner , when introduced into SVHK cells .","gene":["involucrin gene","PKC-gamma"],"gene_indices_start":[0,65],"gene_indices_end":[9,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2222,"text":"The exogenous fos gene was rapidly induced to maximal levels within 1-2 hr of estrogen addition .","gene":["fos gene"],"gene_indices_start":[14],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2223,"text":"In addition , expected decreases in ATIC enzymatic function in ATIC-ALK-containing lymphomas may render these tumors more sensitive to antifolate drugs such as methotrexate .","gene":["ATIC"],"gene_indices_start":[36],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2225,"text":"NaeI , a novel DNA endonuclease , shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43 .","gene":["DNA endonuclease","NaeI","topoisomerase","recombinase"],"gene_indices_start":[0,15,40,58],"gene_indices_end":[4,31,53,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2226,"text":"Expression of class IV ADH mRNA was detected in human stomach but not liver .","gene":["class IV ADH mRNA"],"gene_indices_start":[14],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2227,"text":"Within the 3' terminal 50 nucleotides , the mouse mt 12S rRNA contains a potential 10 bp hairpin structure and a sequence of 15 consecutive nucleotides common to the RNA of the small ribosomal subunit in all systems , but does not contain the mRNA binding site ( ACCUCC ) found in E . coli and corn chloroplast rRNAs .","gene":["mouse mt 12S rRNA","ACCUCC"],"gene_indices_start":[44,263],"gene_indices_end":[61,269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2229,"text":"In addition to its effect in augmenting the neutrophil response to eccentric exercise , vitamin E causes a greater increase in circulating creatine kinase activity , perhaps indicating increased skeletal muscle repair .","gene":["creatine kinase"],"gene_indices_start":[139],"gene_indices_end":[154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2231,"text":"The sequence similarity has suggested that SCG10 and stathmin have been derived from structurally and evolutionarily related genes .","gene":["stathmin","SCG10"],"gene_indices_start":[43,53],"gene_indices_end":[48,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2232,"text":"PSI-G and PSI-K probably have evolved from a gene duplication of an ancestral gene .","gene":["PSI-G","PSI-K"],"gene_indices_start":[0,10],"gene_indices_end":[5,15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2234,"text":"Chimaeric VP16-E2 molecules suggest that the epithelial specific transcriptional activation of the BPV-4 LCR promoter is mediated by the E2 transactivation domain .","gene":["Chimaeric VP16-E2 molecules","E2 transactivation domain"],"gene_indices_start":[0,137],"gene_indices_end":[27,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2236,"text":"Mutations in the alpha and sigma-70 subunits of RNA polymerase affect expression of the mer operon .","gene":["alpha and sigma-70 subunits of RNA polymerase","mer operon"],"gene_indices_start":[17,88],"gene_indices_end":[62,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2237,"text":"Heterogeneity of human serum albumin .","gene":["human serum albumin"],"gene_indices_start":[17],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2239,"text":"This 300 bp 5'-upstream sequence of K3 keratin gene , which can function in vitro as a keratinocyte-specific promoter , contains two clusters of partially overlapping motifs , one with an NFkB consensus sequence and another with a GC box .","gene":["K3 keratin gene","NFkB"],"gene_indices_start":[36,188],"gene_indices_end":[51,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2241,"text":"A mutant form of Vps1p lacking the entire GTP-binding domain interfered with vacuolar protein sorting in wild-type cells .","gene":["Vps1p"],"gene_indices_start":[17],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2243,"text":"Molecular identification of smg-4 , required for mRNA surveillance in C . elegans .","gene":["smg-4"],"gene_indices_start":[28],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2246,"text":"Interestingly , the RNA sequences selected by the mutated zinc knuckle 9G8 variant are efficiently recognized by SRp20 , in agreement with the fact that the RBD of 9G8 and SRp20 are similar .","gene":["9G8","SRp20","zinc knuckle 9G8 variant","SRp20"],"gene_indices_start":[58,113,164,172],"gene_indices_end":[82,118,167,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2247,"text":"Krox-20 , a zinc finger gene , has a highly conserved pattern of expression in r3 and r5 and is functionally required for their maintenance in mouse embryos .","gene":["Krox-20","r3","r5"],"gene_indices_start":[0,79,86],"gene_indices_end":[7,81,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2248,"text":"These results illustrate an important role for La in RNA production by demonstrating its ability to clear the termination sites of class III templates , thereby promoting efficient use of transcription complexes by pol III .","gene":["La","class III templates","pol III"],"gene_indices_start":[47,131,215],"gene_indices_end":[49,150,222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2249,"text":"The cytosolic glutathione S-transferases ( GSTs , EC 2 . 5 . 1 . 18 ) are a superfamily of dimeric isoenzymes which catalyze the conjugation of electrophilic substrates with glutathione .","gene":["glutathione S-transferases","GSTs"],"gene_indices_start":[14,43],"gene_indices_end":[40,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2251,"text":"Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels .","gene":["TSH","TSH"],"gene_indices_start":[89,135],"gene_indices_end":[92,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2253,"text":"The mei4+ gene of the fission yeast Schizosaccharomyces pombe was cloned by functional complementation .","gene":["mei4+ gene"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2254,"text":"Molecular cloning and characterization of two genes encoding gp138 , a cell surface glycoprotein involved in the sexual cell fusion of Dictyostelium discoideum .","gene":["genes encoding gp138"],"gene_indices_start":[46],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2259,"text":"Fluorescence in situ hybridization of metaphase spreads of chromosome 8 , containing hybrid cell line 706-B6 clone 17 ( CL-17 ) with cosmid c101F1 , placed the 9804 gene close to the telomere at 8q24 . 3 .","gene":["9804 gene"],"gene_indices_start":[160],"gene_indices_end":[169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2261,"text":"Recent studies have demonstrated that the activated GH receptor can stimulate Stat1 , a cytoplasmic transcription factor that becomes tyrosine phosphorylated and translocates to the nucleus , where it can interact with specific DNA sequences to modulate gene expression .","gene":["Stat1","GH receptor"],"gene_indices_start":[52,78],"gene_indices_end":[63,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2262,"text":"Different sequence elements of both the retroviral vectors and the c-myc gene recombined during genesis of highly oncogenic retroviruses CMII , MC29 , or MH2 .","gene":["c-myc gene"],"gene_indices_start":[67],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2264,"text":"Effect of 2- ( p-chlorophenyl ) cyclopropylamine on 5-hydroxyindole concentration and monoamine oxidase activity in rat brain .","gene":["monoamine oxidase"],"gene_indices_start":[86],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2265,"text":"Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor , such as W57 and L58 , as well as to an AP-recruiting dileucine motif and to an acidic dipeptide in the C-terminal region of the protein .","gene":["CD4","AP-recruiting dileucine motif","Nef"],"gene_indices_start":[25,102,164],"gene_indices_end":[28,105,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2266,"text":"Furthermore , we notice two potential consensus motifs which are also found in corresponding positions in the genes for the nerve growth factor receptor and the 68-kDa neurofilament protein .","gene":["nerve growth factor receptor","68-kDa neurofilament protein"],"gene_indices_start":[124,161],"gene_indices_end":[152,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2268,"text":"Mg-chelatase of tobacco : identification of a Chl D cDNA sequence encoding a third subunit , analysis of the interaction of the three subunits with the yeast two-hybrid system , and reconstitution of the enzyme activity by co-expression of recombinant CHL D , CHL H and CHL I .","gene":["recombinant CHL D","CHL I","Chl D cDNA sequence","CHL H","Mg-chelatase"],"gene_indices_start":[0,46,240,260,270],"gene_indices_end":[12,65,257,265,275],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2270,"text":"Interferon-alpha-induced gene expression : evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex .","gene":["ISGF3 transcription complex"],"gene_indices_start":[107],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2271,"text":"Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107 \/ MER2 .","gene":["REC107 \/ MER2","yeast early meiotic recombination genes REC102"],"gene_indices_start":[38,89],"gene_indices_end":[84,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2272,"text":"Antibodies made against fusion protein produced by the DP1A clone reacted specifically with DP-I and -II on immunoblots .","gene":["DP-I and -II","DP1A"],"gene_indices_start":[55,92],"gene_indices_end":[59,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2274,"text":"Binding of U2 small nuclear ribonucleoprotein was partially inhibited .","gene":["U2 small nuclear ribonucleoprotein"],"gene_indices_start":[11],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2276,"text":"Heme oxygenase 1 is an essential enzyme in heme catabolism that cleaves heme to form biliverdin , iron , and carbon monoxide .","gene":["Heme oxygenase 1"],"gene_indices_start":[0],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2277,"text":"The characteristic feature of liver and spleen MP function in patients with VHA associated with HBsAg carriership consisted in the lack of the compensatory reaction on the part of spleen MP , which was likely to be connected with overstrain of long standing and depletion of the MP system due to permanent antigenic stimulation of HBsAg .","gene":["HBsAg","HBsAg"],"gene_indices_start":[96,331],"gene_indices_end":[101,336],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2278,"text":"Since the RINX gene is likely an ortholog of the goldfish Vsx1 gene , it has been named VSX1 by the Human Gene Nomenclature Committee .","gene":["goldfish Vsx1 gene","RINX gene","VSX1"],"gene_indices_start":[10,49,88],"gene_indices_end":[19,67,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2279,"text":"The hepatitis A virus antibody ( anti-HAV ) in chronic diffuse liver diseases .","gene":["hepatitis A virus antibody","anti-HAV"],"gene_indices_start":[4,33],"gene_indices_end":[30,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2280,"text":"Nature 398 , 828-830 ) that the amino acid sequences of peptide fragments obtained from a polypeptide found in a complex of proteins that alters chromatin structure ( ARC ) are identical to portions of the deduced open reading frame of TIG-1 mRNA .","gene":["ARC","TIG-1 mRNA"],"gene_indices_start":[167,236],"gene_indices_end":[170,246],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2291,"text":"From two inhibitor scaffolds , we have identified potent and selective inhibitors for sensitized kinases from five distinct subfamilies .","gene":["kinases"],"gene_indices_start":[97],"gene_indices_end":[104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2293,"text":"A distinct staining pattern for the N-utrophin was not detectable , although it was expected to localise at the actin stress fibers .","gene":["N-utrophin","actin"],"gene_indices_start":[36,112],"gene_indices_end":[46,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2296,"text":"Accumulated evidence indicates that , upon stimulation with interferon-gamma ( IFN-gamma ) , three beta-type subunits , designated LMP2 , LMP7 , and PSMB10 , are incorporated into the 20S proteasome by displacing the housekeeping beta-type subunits designated PSMB6 , PSMB5 , and PSMB7 , respectively .","gene":["LMP7","20S proteasome","IFN-gamma","PSMB6","LMP2","interferon-gamma","PSMB10","PSMB7","PSMB5"],"gene_indices_start":[60,79,131,138,149,184,260,268,280],"gene_indices_end":[76,88,135,142,155,198,265,273,285],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2298,"text":"The Dax-1 gene encodes a protein that is structurally related to members of the orphan nuclear receptor superfamily .","gene":["Dax-1 gene","orphan nuclear receptor superfamily"],"gene_indices_start":[4,80],"gene_indices_end":[14,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2299,"text":"Human AP-2rep repressed both reporter expression from a transiently transfected AP-2alpha promoter and the endogenous AP-2alpha gene and inversely was negatively regulated by AP-2alpha .","gene":["AP-2alpha promoter","AP-2alpha","AP-2alpha gene","Human AP-2rep"],"gene_indices_start":[0,80,118,175],"gene_indices_end":[13,98,132,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2301,"text":"Similarly , the N-terminal cytoplasmic domain of the latent membrane protein 2A ( LMP2A ) of the Epstein-Barr virus ( EBV ) contains a single copy of the Tyr-X-X-Leu \/ Ile-containing motif which could play a critical role in B cell transformation .","gene":["latent membrane protein 2A","Tyr-X-X-Leu \/ Ile-containing motif","LMP2A"],"gene_indices_start":[53,82,154],"gene_indices_end":[79,87,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2302,"text":"The N-terminal small segment of yeast TAF145 ( yTAF145 ) binds to TBP and thereby inhibits TBP function .","gene":["TBP","yeast TAF145","yTAF145","TBP"],"gene_indices_start":[32,47,66,91],"gene_indices_end":[44,54,69,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2303,"text":"VEGF promoter activity in transient transfections was decreased by either pharmacological or genetic inhibition of EGFR , Ras , or phosphatidylinositol 3'-kinase [ PI ( 3 ) kinase ] .","gene":["phosphatidylinositol 3'-kinase","VEGF promoter","Ras","[ PI ( 3 ) kinase ]","EGFR"],"gene_indices_start":[0,115,122,131,162],"gene_indices_end":[13,119,125,161,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2304,"text":"A murine expressed sequence tag ( EST ) showing homology with erythropoietin receptor ( EPOR ) was identified in the EST database .","gene":["EPOR","erythropoietin receptor"],"gene_indices_start":[62,88],"gene_indices_end":[85,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2305,"text":"The Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene is required for S-phase and G2 \/ M arrest in response to both DNA damage and incomplete DNA replication .","gene":["Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene"],"gene_indices_start":[4],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2307,"text":"32Pi labeling or isoelectric focusing analysis of eIF-2 alpha from conditional casein kinase II mutants indicated that phosphorylation of eIF-2 alpha is abolished or dephosphorylated forms of eIF-2 alpha are detected when these strains are grown at the restrictive growth conditions .","gene":["eIF-2 alpha","eIF-2 alpha","eIF-2 alpha","casein kinase II mutants"],"gene_indices_start":[50,79,138,192],"gene_indices_end":[61,103,149,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2309,"text":"Immunostaining of cells transfected with these constructs revealed that both the myristoylated and nonmyristoylated mutants were localized in nuclei , whereas wild-type PKC alpha was primarily cytoplasmic and perinuclear .","gene":["wild-type PKC alpha"],"gene_indices_start":[159],"gene_indices_end":[178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2310,"text":"Plasma lecithin \/ cholesterol acyltransferase ( LCAT ) activity in multiple-organ donors : a predictor of allograft viability in clinical liver transplantation .","gene":["LCAT","Plasma lecithin \/ cholesterol acyltransferase"],"gene_indices_start":[0,48],"gene_indices_end":[45,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2311,"text":"Western blot analysis of various bovine tissues with human NMT peptide antibody indicated a common prominent immunoreactive band with an apparent molecular mass of 48 . 5-50 kDa in all tissues .","gene":["NMT peptide antibody"],"gene_indices_start":[59],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2313,"text":"Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1 .","gene":["RXR","apoAI gene basal promoter","ARP-1"],"gene_indices_start":[81,123,283],"gene_indices_end":[84,148,288],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2315,"text":"When this DNA fragment was placed upstream of the chloramphenicol acetyltransferase ( CAT ) reporter gene and transfected into a carp CF cell line , it could drive the synthesis of CAT enzyme 16 times more efficiently than the promoterless pCAT-Basic .","gene":["chloramphenicol acetyltransferase","CAT","pCAT-Basic","CAT enzyme"],"gene_indices_start":[50,86,181,240],"gene_indices_end":[83,89,191,250],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2320,"text":"These results show that the CAAT-region is involved in upregulating the MDR1 promoter in HL60 \/ VCR cells .","gene":["MDR1 promoter"],"gene_indices_start":[72],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2323,"text":"While interactions of WT and variant TGF-alpha with the ErbBs all result in ErbB2 activation , they produce different biological consequences , suggesting that the various TGF-alpha precursors differentially modulate ErbB signaling .","gene":["WT","ErbB","ErbB2","TGF-alpha precursors","TGF-alpha","ErbBs"],"gene_indices_start":[22,37,56,76,172,217],"gene_indices_end":[24,46,61,81,192,221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2324,"text":"By contrast , secretory HI antibodies were not demonstrated at the onset of illness in any of the patients , but their formation started early and the antibodies reached maximal levels about 10 days after onset of illness .","gene":["secretory HI antibodies"],"gene_indices_start":[14],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2325,"text":"Mammalian ABPs and SHBGs bind sex steroids with high affinity , but some binding properties differ among species .","gene":["SHBGs","Mammalian ABPs"],"gene_indices_start":[0,19],"gene_indices_end":[14,24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2326,"text":"PRDII-BF1-derived cDNAs did not result in stimulation of either basal or tat-induced activated gene expression .","gene":["PRDII-BF1-derived cDNAs"],"gene_indices_start":[0],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2328,"text":"We isolated several overlapping A-phage and cosmid clones that cover more than 100 kb of human DNA and contained the entire VDR gene .","gene":["VDR gene"],"gene_indices_start":[124],"gene_indices_end":[132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2329,"text":"The treatment group also showed in vivo T-cell activation with an initial lymphopenia followed by a rebound lymphocytosis and upregulation of the subset markers CD25 ( interleukin 2 receptor ) and CD45RO ( T-memory cells ) .","gene":["CD25","interleukin 2 receptor","CD45RO"],"gene_indices_start":[161,168,197],"gene_indices_end":[165,190,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2331,"text":"Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1 \/ c-fms signaling .","gene":["mitogen-activated protein kinases p42","colony-stimulating factor 1","c-fms","ets-2","p44"],"gene_indices_start":[25,67,75,112,142],"gene_indices_end":[62,70,80,139,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2334,"text":"Coenzyme Q10 : blood levels and metabolic demand .","gene":["Coenzyme Q10"],"gene_indices_start":[0],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2335,"text":"A drug with ISA \"down regulates\" beta receptors ; thus , when the drug is withdrawn there is no post-beta-blocking drug hypersensitivity in contrast to agents without ISA .","gene":["beta receptors"],"gene_indices_start":[33],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2336,"text":"The workup included skin tests ( up to 1 microgram \/ ml , Pharmacia ) , measurement of specific serum IgE with RAST-CAP ( Pharmacia ) , and CAST with three concentrations of bee ( Apis mellifera ) and wasp ( Vespula spec . ) venom ( Aquagen ALK ) .","gene":["IgE"],"gene_indices_start":[102],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2337,"text":"A position-independent activation domain which contained conserved regions II and III was identified at the carboxyl terminus of the HNF-3 beta protein ( amino acids 361 to 458 ) .","gene":["HNF-3 beta protein"],"gene_indices_start":[133],"gene_indices_end":[151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2338,"text":"Mutations in genes encoding PR65 \/ A subunits have been identified in several different human cancers and the PP2A inhibitor , termed fostriecin , is being tested as an anticancer drug .","gene":["PR65 \/ A subunits","PP2A"],"gene_indices_start":[28,110],"gene_indices_end":[45,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2339,"text":"In contrast to the wild-type protein , expression of p45 NF-E2 lacking this activation domain in an NF-E2 null cell line fails to support enhancer-dependent transcription in transient assays .","gene":["p45 NF-E2","NF-E2"],"gene_indices_start":[53,100],"gene_indices_end":[62,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2342,"text":"Abrogation of p53 function by E6 resulted in an increase in the spontaneous mutation frequencies at the heterozygous thymidine kinase ( TK ) locus but not at the hemizygous hypoxanthine phosphoribosyl transferase ( HPRT ) locus .","gene":["E6","TK","thymidine kinase","p53","HPRT","hypoxanthine phosphoribosyl transferase"],"gene_indices_start":[14,30,117,136,173,215],"gene_indices_end":[17,32,133,138,212,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2345,"text":"ECM disruption in Lytechinus embryos caused a relative drop in USF RNA accumulation levels to approximately 60% of control embryos , while LpS1 RNA accumulation levels dropped to less than 5% .","gene":["LpS1 RNA","USF RNA"],"gene_indices_start":[63,139],"gene_indices_end":[70,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2349,"text":"Electrophoretic mobility shift analysis indicates that NF-IL-6 , as well as other related members of this family , bind specifically to the NF-IL-6 site in the IL-8 promoter .","gene":["NF-IL-6","NF-IL-6","IL-8 promoter"],"gene_indices_start":[55,140,160],"gene_indices_end":[62,147,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2356,"text":"As with VP16 , the transactivation function of Luman is also regulated by HCF .","gene":["VP16","Luman","HCF"],"gene_indices_start":[8,47,74],"gene_indices_end":[12,52,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2357,"text":"Slowly adapting type I mechanoreceptor discharge as a function of dynamic force versus dynamic displacement of glabrous skin of raccoon and squirrel monkey hand .","gene":["type I mechanoreceptor"],"gene_indices_start":[16],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2359,"text":"Interestingly , although E domains of these two receptors are much less conserved , replacement of this domain in rtER by its human counterpart resulted in higher estradiol sensitivity but no increase in the magnitude of transactivation .","gene":["rtER","E domains"],"gene_indices_start":[25,114],"gene_indices_end":[34,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2361,"text":"From sequence alignments with phylogenetically related viruses , including tymoviruses , we predicted that p223 contained a papain-like proteinase domain with a putative catalytic cysteine994 and histidine1075 .","gene":["papain-like proteinase domain","p223"],"gene_indices_start":[107,124],"gene_indices_end":[111,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2362,"text":"The distribution of their fibrinogen levels was Gaussian , but more wide-based than the distribution of our normal controls .","gene":["fibrinogen"],"gene_indices_start":[26],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2367,"text":"Lens aldose reductase in diabetic and galactosemic cataracts .","gene":["Lens aldose reductase"],"gene_indices_start":[0],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2369,"text":"The virus encodes a 40-kDa protein , tax , that is important for the immortalization of T cells .","gene":["tax"],"gene_indices_start":[37],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2370,"text":"[ Ala85 ] Dk ( 69-85 ) retains full biological activity .","gene":["[ Ala85 ] Dk ( 69-85 )"],"gene_indices_start":[0],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2371,"text":"Platelet serotonin ( 5-HT ) and 5-HT releasing factor in plasma of migrainous patients .","gene":["5-HT releasing factor"],"gene_indices_start":[32],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2377,"text":"A phylogenetic analysis of the reverse transcriptase domain confirms our differential genetic assessment that Cyclops from pea is a novel element with no specific relationship to the previously described Gypsy-like elements from plants .","gene":["Cyclops","Gypsy-like elements","reverse transcriptase domain"],"gene_indices_start":[31,110,204],"gene_indices_end":[59,117,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2378,"text":"Instead , it contained two tandem kappaB elements and a variant activating transcription factor \/ cAMP response element site , which closely resembled sites in the E-selectin gene that are required for TNF-alpha- or LPS-inducible expression .","gene":["kappaB elements","activating transcription factor \/ cAMP response element","E-selectin gene"],"gene_indices_start":[34,64,164],"gene_indices_end":[49,119,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2380,"text":"This paper describes the genomic organization of mouse gC1qBP and the characterization of its 5' flanking region .","gene":["gC1qBP"],"gene_indices_start":[55],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2381,"text":"PRL-1 is able to dephosphorylate phosphotyrosine substrates , and mutation of the active-site cysteine residue abolishes this activity .","gene":["PRL-1"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2384,"text":"The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5-mediated transcriptional induction .","gene":["Stat5","glucocorticoid receptor"],"gene_indices_start":[14,59],"gene_indices_end":[37,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2385,"text":"This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration .","gene":["vasopressin"],"gene_indices_start":[38],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2386,"text":"This repressor is however unlikely to mediate spi 2 . 3 3' UTR silencer action since it was not detected in rat hepatocytes .","gene":["spi 2 . 3 3' UTR silencer"],"gene_indices_start":[46],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2391,"text":"Interestingly , the RXRalphaF318A constitutive activity generated within heterodimers in the presence of BMS614 requires the integrity of both RXR and RAR AF-2 domains .","gene":["RAR","RXR","RXRalphaF318A","AF-2 domains"],"gene_indices_start":[20,143,151,155],"gene_indices_end":[33,146,154,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2394,"text":"The amino-terminal third of the protein contains a high-mobility-group motif characteristic of DNA-binding proteins .","gene":["high-mobility-group motif"],"gene_indices_start":[51],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2395,"text":"In rlf2 mutants , telomeric chromatin is perturbed : Telomeric silencing is reduced and Rap1p localization is altered .","gene":["rlf2 mutants","Rap1p"],"gene_indices_start":[3,88],"gene_indices_end":[15,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2396,"text":"Solution structure and mechanism of the MutT pyrophosphohydrolase .","gene":["MutT pyrophosphohydrolase"],"gene_indices_start":[40],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2397,"text":"Among the H \/ ACA snoRNAs associated with Gar1p , one can distinguish a large group of snoRNAs that are not essential in yeast and serve as guides for pseudouridine synthesis onto the pre-rRNA molecule .","gene":["Gar1p","H \/ ACA snoRNAs","pre-rRNA molecule","snoRNAs"],"gene_indices_start":[10,42,87,184],"gene_indices_end":[25,47,94,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2399,"text":"A significant degree of homology was also found among these genes and the Mtase gene of related phage SPR , which codes for an enzyme with different modification specificity .","gene":["Mtase gene"],"gene_indices_start":[74],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2402,"text":"Additional deletion mutations revealed a new , 67-amino-acid functional domain within the proline-rich region of SLP-76 , which we have termed the P-1 domain .","gene":["P-1 domain","SLP-76"],"gene_indices_start":[113,147],"gene_indices_end":[119,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2403,"text":"The deduced amino acid sequence has the greatest homology ( 61% ) to the green alga Scenedemus obliquus plastocyanin .","gene":["green alga Scenedemus obliquus plastocyanin"],"gene_indices_start":[73],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2406,"text":"When nifA mRNA 5' start points were mapped by primer extension , both a minor upstream transcript ( s ) starting 45 bp distal to the anaerobox and a major downstream transcript starting 10 bp distal to the sigma 54 box were observed .","gene":["nifA mRNA","sigma 54"],"gene_indices_start":[5,206],"gene_indices_end":[14,214],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2407,"text":"The sequence of monkey opsin closely resembles the human sequence at the nucleotide and the amino acid levels , with the latter having only 7 differences out of 348 residues .","gene":["monkey opsin"],"gene_indices_start":[16],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2409,"text":"Its potential as a diagnostic tool for epidemiological surveillance was assessed in comparison with three other diagnostic tests : stool examination , ELISA with soluble egg antigen ( SEA ) and the circumoval precipitin test ( COPT ) .","gene":["soluble egg antigen","SEA"],"gene_indices_start":[162,184],"gene_indices_end":[181,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2410,"text":"Albumin expression is maintained in the liver by a combination of liver-enriched transcription factors such as CAAT enhancer-binding protein ( C \/ EBP ) alpha and C \/ EBPbeta .","gene":["C \/ EBPbeta","CAAT enhancer-binding protein ( C \/ EBP ) alpha","Albumin"],"gene_indices_start":[0,111,163],"gene_indices_end":[7,158,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2413,"text":"A gapped search with the C-terminal region of CDED \/ LIOR revealed a 36-41% similarity to several proteins related to signal transduction and cell replication , such as ORC1 and KSR .","gene":["KSR","ORC1","CDED \/ LIOR"],"gene_indices_start":[46,169,178],"gene_indices_end":[57,173,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2414,"text":"Circulating oxytocin in male guinea pigs affected by the female cohabitation and reproductive condition .","gene":["oxytocin"],"gene_indices_start":[12],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2416,"text":"The COL7A1 gene , which encodes type VII collagen , has been implicated as a candidate gene for dominantly and recessively inherited forms of dystrophic epidermolysis bullosa .","gene":["type VII collagen","COL7A1 gene"],"gene_indices_start":[4,32],"gene_indices_end":[15,49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2417,"text":"Cell factor-mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate-early ( IE ) gene ( J .","gene":["HCMV major immediate-early ( IE ) gene"],"gene_indices_start":[105],"gene_indices_end":[143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2418,"text":"AIMS : To establish a baseline and intraindividual fluctuations of the tumour markers CEA , CA 50 and CA 242 in patients cured from colorectal cancer , and to test the hypothesis that serum concentrations and intraindividual fluctuations do not differ from the concentrations in cancer-free individuals .","gene":["CA 242","CA 50","CEA"],"gene_indices_start":[86,92,102],"gene_indices_end":[89,97,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2419,"text":"Effects of thromboxane synthetase inhibition on postburn mesenteric vascular resistance and the rate of bacterial translocation in a chronic porcine model .","gene":["thromboxane synthetase"],"gene_indices_start":[11],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2421,"text":"The transforming protein of Rous sarcoma virus , pp60v-src , and its normal cellular homolog , pp60c-src , differ not only in oncogenic potential but also in their subcellular localization and cytoskeletal binding ability . pp60v-src has been shown to stably associate with a detergent-insoluble cytoskeletal matrix , whereas pp60c-src does not .","gene":["pp60c-src","pp60v-src","pp60c-src","pp60v-src"],"gene_indices_start":[49,95,224,326],"gene_indices_end":[58,104,233,335],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2422,"text":"DNA from PCR was labeled and used to isolate several lambda gt11 cDNA clones , including one full-length one ( Dd kinase-2 ) .","gene":["Dd kinase-2"],"gene_indices_start":[111],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2423,"text":"The importin alpha . beta heterodimer mediates nuclear import of proteins containing classical nuclear localization signals .","gene":["importin alpha . beta heterodimer"],"gene_indices_start":[4],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2430,"text":"Gel-shift assays with nuclear extracts and oligonucleotide sequences spanning the 0 . 125-kb promoter region detected an ETS-immunoreactive complex , present most abundantly in cells overexpressing HER2 , whose high-affinity binding depended on the GAGGAA response element .","gene":["GAGGAA response element","HER2"],"gene_indices_start":[198,249],"gene_indices_end":[202,272],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2431,"text":"Northern analyses of RNAs from mouse tissues and cell lines indicated that p11 mRNA levels vary widely .","gene":["p11 mRNA"],"gene_indices_start":[75],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2432,"text":"Further research is required to better measure treatment effects , modification of MS natural history , and net societal costs of IFN beta-1b in RRMS .","gene":["IFN beta-1b"],"gene_indices_start":[130],"gene_indices_end":[141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2436,"text":"Data from the V-HeFT II show that at 2-year follow-up , a progressive rise of plasma norepinephrine was observed in both treatment arms , suggesting that disease progresses despite treatment with either an angiotensin-converting enzyme inhibitor , enalapril , or vasodilator therapy with hydralazine \/ isosorbide dinitrate .","gene":["angiotensin-converting enzyme"],"gene_indices_start":[206],"gene_indices_end":[235],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2438,"text":"Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors .","gene":["kinase domain","Eph receptors"],"gene_indices_start":[44,136],"gene_indices_end":[57,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2440,"text":"The effect of pure natural porcine secretin on endocrine and exocrine pancreatic secretion was studied in the totally isolated perfused porcine pancreas .","gene":["porcine secretin"],"gene_indices_start":[27],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2441,"text":"Exogenous LHRH is also known to facilitate mating behavior in several species .","gene":["LHRH"],"gene_indices_start":[10],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2443,"text":"The in vivo profile of ZFH-2 in the larval CNS shows intriguing overlap with DDC in specific serotonin and dopamine neurons .","gene":["ZFH-2","DDC"],"gene_indices_start":[23,77],"gene_indices_end":[28,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2444,"text":"Using this reporter gene system , we previously showed that EPO-induced activation of the c-fos promoter can be detected rapidly and sensitively as an elevation of cellular luciferase activity .","gene":["c-fos promoter","cellular luciferase"],"gene_indices_start":[90,164],"gene_indices_end":[104,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2446,"text":"These characteristic structural features were used to create the abbreviation AZF1 ( Asparagine-rich Zinc Finger protein ) .","gene":["AZF1","Asparagine-rich Zinc Finger protein"],"gene_indices_start":[78,85],"gene_indices_end":[82,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2448,"text":"Cost-effectiveness of interferon beta-1b in slowing multiple sclerosis disability progression .","gene":["interferon beta-1b"],"gene_indices_start":[22],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2449,"text":"Pseudosubstrate ( 19-36 ) , derived from the C-terminus of Ca-dependent PKC isotypes , inhibited beta-PKC but not nPKC activity using either Histone IIIS or peptide ( 19-31 ) as substrate .","gene":["Histone IIIS","nPKC","Ca-dependent PKC isotypes","beta-PKC"],"gene_indices_start":[59,97,114,141],"gene_indices_end":[84,105,118,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2451,"text":"Structure , promoter analysis and chromosomal assignment of the human APEX gene .","gene":["human APEX gene"],"gene_indices_start":[64],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2452,"text":"Upon tyrosine phosphorylation at the ITIMs , these molecules recruit SH2 domain-containing phosphatases such as SH2-containing tyrosine phosphatase-1 and negatively regulate cell activity .","gene":["tyrosine phosphatase-1","phosphatases","SH2"],"gene_indices_start":[69,91,127],"gene_indices_end":[72,103,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2453,"text":"Homologous recombination between the Autographa californica nuclear polyhedrosis virus ( AcNPV ) genome and a 0 . 6-kbp-long DNA fragment derived from the putative DNA helicase gene of Bombyx mori nuclear polyhedrosis virus generates eh2-AcNPV , an expanded-host-range AcNPV mutant ( S .","gene":["DNA helicase gene of Bombyx mori nuclear polyhedrosis virus"],"gene_indices_start":[164],"gene_indices_end":[223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2455,"text":"Both variants display the seven-transmembrane topology that is typical for G protein-coupled receptors .","gene":["G protein-coupled receptors"],"gene_indices_start":[75],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2456,"text":"This region does not contain an identifiable TATA element , indicating that transcription of the glutaminase gene is driven by a TATA-less promoter .","gene":["glutaminase gene"],"gene_indices_start":[97],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2457,"text":"Age > \/ = 50 years ( odds ratio [ OR ] , 14 . 1 ) , BMI > \/ = 28 kg \/ m ( 2 ) ( OR , 5 . 7 ) , triglycerides > \/ = 1 . 7 mmol \/ L ( OR , 5 ) , and alanine aminotransferase ( ALT ) > \/ = 2N ( OR , 4 . 6 ) were independently associated with septal fibrosis .","gene":["ALT","alanine aminotransferase"],"gene_indices_start":[147,174],"gene_indices_end":[171,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2461,"text":"Furthermore , the DNA polymerase II complex was difficult to obtain from dpb2-1 mutant cells , suggesting that a stable DNA polymerase II complex requires DPB2 and is essential for chromosomal replication .","gene":["DNA polymerase II complex","DPB2","dpb2-1","DNA polymerase II complex"],"gene_indices_start":[18,73,120,155],"gene_indices_end":[43,79,145,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2463,"text":"Levels of the MEK inhibitor PD98059 that block EGF-induced mitogenesis and MAP kinase phosphorylation also abrogate EGF-induced focal adhesion disassembly and cell motility .","gene":["MAP kinase","MEK"],"gene_indices_start":[14,75],"gene_indices_end":[17,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2464,"text":"IFI16 consists of ten exons and nine intervening introns spanning at least 28 kilobases ( kb ) of DNA .","gene":["IFI16"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2466,"text":"In a heterologous transcriptional system in which the upstream regions of oIFNtau were inserted in front of simian virus 40 ( SV40 ) promoter , the regions between bases -654 and -555 were determined as being the enhancer region required for oIFNtau-SV40-CAT transactivation .","gene":["oIFNtau-SV40-CAT","simian virus 40 ( SV40 ) promoter","oIFNtau"],"gene_indices_start":[74,108,242],"gene_indices_end":[81,141,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2467,"text":"The evidence presented here suggests that the p40 complex is a ribonucleoprotein complex containing L1Hs RNA ( s ) and that protein-protein interactions in which alpha-helix structures participate , for example coiled-coils , may occur in the complex .","gene":["L1Hs RNA ( s )","p40 complex"],"gene_indices_start":[46,100],"gene_indices_end":[57,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2469,"text":"Two major and one minor transcription initiation sites were assigned to positions +1 and +24 and position +14 , respectively , by a combination of ribonuclease protection , primer extension , and 5' RACE analyses .","gene":["ribonuclease"],"gene_indices_start":[147],"gene_indices_end":[159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2470,"text":"Taking into consideration weight and seasonal changes in bone mass , total ( TBBMC ) and regional body bone mineral content were measured in 38 women treated with GnRH agonists for 6 months for endometriosis or leiomyomata .","gene":["GnRH"],"gene_indices_start":[163],"gene_indices_end":[167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2472,"text":"SCFFWD1 may be critical for tumor development and suppression through regulation of beta-catenin protein stability .","gene":["SCFFWD1","beta-catenin protein"],"gene_indices_start":[0,84],"gene_indices_end":[7,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2473,"text":"In addition to the previously identified and characterized attenuator 1 situated 93 nucleotides downstream from the major late transcription start site , a second attenuator , attenuator 2 , situated 55 nucleotides downstream from it , has been identified .","gene":["attenuator 2","attenuator 1"],"gene_indices_start":[59,176],"gene_indices_end":[71,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2477,"text":"After cells were stably transfected with CIITA , endogenous MHC class II genes were constitutively expressed , and MHC class II promoters , delivered by transfection , were actively transcribed in CIITA-expressing cells .","gene":["MHC class II promoters","MHC class II genes","CIITA"],"gene_indices_start":[41,60,115],"gene_indices_end":[46,78,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2478,"text":"POU-specific and POU-homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence .","gene":["Oct3","POU-homeo domains"],"gene_indices_start":[17,38],"gene_indices_end":[34,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2481,"text":"Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor ( CSF-1 ) is dependent upon the level of cell-surface receptor .","gene":["urokinase plasminogen activator gene","CSF-1","macrophage colony-stimulating factor"],"gene_indices_start":[14,110,149],"gene_indices_end":[50,146,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2482,"text":"Polyclonal antibodies against the N-terminal part ( amino acids 12-363 ) and the C-terminal part ( amino acids 330-730 ) of rainbow trout HIF-1alpha protein recognized rainbow trout and chinook salmon HIF-1alpha protein in Western blot analysis .","gene":["rainbow trout HIF-1alpha protein","rainbow trout and chinook salmon HIF-1alpha protein"],"gene_indices_start":[124,168],"gene_indices_end":[156,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2487,"text":"The two different phosphoforms of STAT5 have identical in vitro DNA binding specificity and reactivity with tyrosine phosphopeptides , but differ in their cellular localization .","gene":["STAT5"],"gene_indices_start":[34],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2490,"text":"Sequence comparisons of prokaryotic RCR initiators has revealed a set of three common motifs , two of which , a putative metal coordination site and a downstream active-site tyrosine motif , could be tentatively identified in parvoviral replicator proteins .","gene":["prokaryotic RCR initiators","parvoviral replicator proteins"],"gene_indices_start":[24,226],"gene_indices_end":[50,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2494,"text":"A major mechanism whereby steroid hydroxylase gene transcription is regulated in the adrenal cortex requires the pituitary peptide hormone , ACTH , which acts via cAMP .","gene":["ACTH","steroid hydroxylase gene"],"gene_indices_start":[26,141],"gene_indices_end":[50,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2495,"text":"AF showed a mixed nuclear \/ cytoplasmic pattern of expression in the epithelial , endothelial , and stromal component of the normal breast and benign lesions , whereas an impressive loss of AF expression was noted in in situ and invasive breast cancer and tumoral stroma .","gene":["AF","AF"],"gene_indices_start":[0,190],"gene_indices_end":[2,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2496,"text":"Based on 213 determinations , the control mean serum CPK activity was 262 + \/ - 113 I . U . \/ liter .","gene":["serum CPK"],"gene_indices_start":[47],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2497,"text":"In vivo , selective activation of SAPKs stimulates formation of the ternary complex containing Elk-1 , serum response factor and the serum response element , and enhances Elk-1-dependent transcription .","gene":["serum response element","Elk-1","SAPKs","serum response factor"],"gene_indices_start":[34,95,103,133],"gene_indices_end":[39,100,124,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2499,"text":"A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function .","gene":["suppressor of Hairy-wing protein"],"gene_indices_start":[31],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2500,"text":"Analysis of the inferred 1 , 859-residue ama-1 product showed considerable identity with the largest subunit of RNAP II from other organisms , including the presence of a zinc finger motif near the amino terminus , and a carboxyl-terminal domain of 42 tandemly reiterated heptamers with the consensus Tyr Ser Pro Thr Ser Pro Ser .","gene":["RNAP II","1 , 859-residue ama-1 product"],"gene_indices_start":[25,112],"gene_indices_end":[54,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2501,"text":"The two contiguous IGF2 ( human insulin-like growth factor II ) and H19 genes are reciprocally imprinted in both human and mouse .","gene":["H19 genes","IGF2","human insulin-like growth factor II"],"gene_indices_start":[19,26,68],"gene_indices_end":[23,61,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2503,"text":"In serum-stimulated cells , the binding of NF-Y \/ CBF to TKC1 increased gradually , reaching a plateau at the S phase .","gene":["NF-Y \/ CBF","TKC1"],"gene_indices_start":[43,57],"gene_indices_end":[53,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2506,"text":"One missense allele ( P236S ) with complete loss of function at 30 degreesC and four missense alleles ( L173F , E225K , S269L and E274K ) that conferred a temperature sensitive phenotype were identified .","gene":["E274K","S269L","P236S","E225K","L173F"],"gene_indices_start":[22,104,112,120,130],"gene_indices_end":[27,109,117,125,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2509,"text":"Here we have determined the nucleotide sequence of 3 . 5 kb from the 3' end of delta gag to the 3' end of molecularly cloned proviral MH2 DNA , in order to elucidate the genetic structure of the virus and to compare it with other mht - and myc-containing oncogenic viruses as well as with the chicken proto-myc gene .","gene":["delta gag","mht","chicken proto-myc gene"],"gene_indices_start":[79,230,293],"gene_indices_end":[88,233,315],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2510,"text":"Concurrent with ligand-dependent uptake , we now show that the receptor undergoes ligand-induced ubiquitination , suggesting that receptor ubiquitination may function in the ligand-dependent endocytosis of the a-factor receptor as well as in its constitutive endocytosis .","gene":["a-factor receptor"],"gene_indices_start":[210],"gene_indices_end":[227],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2511,"text":"Cleavage and DNA joining reactions , carried out by human immunodeficiency virus type 1 ( HIV-1 ) integrase , are necessary to effect the covalent insertion of HIV-1 DNA into the host genome .","gene":["human immunodeficiency virus type 1 ( HIV-1 ) integrase"],"gene_indices_start":[52],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2512,"text":"Immunoprecipitation experiments using DokR-specific antibodies revealed an interaction between endogenous DokR and a 150-kDa protein that is tyrosine-phosphorylated in EGF-stimulated BaF \/ 3 cells .","gene":["DokR-specific antibodies","endogenous DokR"],"gene_indices_start":[38,95],"gene_indices_end":[62,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2513,"text":"The requirement for proteolytic activity of both FVIIa and FXa suggests that protease-activated receptors may be involved .","gene":["FVIIa","FXa"],"gene_indices_start":[49,59],"gene_indices_end":[54,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2516,"text":"The cDNA corresponding to the FPS1 gene was isolated by functional complementation of a mutant yeast strain defective in FPS activity ( Delourme , D . , Lacroute , F . , and Karst , F .","gene":["FPS1 gene","FPS"],"gene_indices_start":[30,121],"gene_indices_end":[39,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2518,"text":"In the present study , we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity , due to the continued cytoplasmic sequestration of RelA ( p65 ) by TD-IkappaBalpha .","gene":["acetate-phytohemagglutinin","TD-IkappaBalpha","RelA ( p65 )","tumor necrosis factor","NF-kappaB","IkappaBalpha gene","TD-IkappaBalpha"],"gene_indices_start":[57,99,129,165,211,294,310],"gene_indices_end":[72,125,150,182,220,306,325],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2520,"text":"Unique to this system , the activity of TraR is negatively modulated by an antiactivator called TraM .","gene":["TraM","TraR"],"gene_indices_start":[40,96],"gene_indices_end":[44,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2523,"text":"Interestingly , the positions of these introns have been conserved in comparison with the genes of two other transglutaminase-like activities described in the literature , but the TGM1 gene is by far the smallest characterized to date because its introns are relatively smaller .","gene":["TGM1 gene"],"gene_indices_start":[180],"gene_indices_end":[189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2525,"text":"In addition , anti-phosphotyrosine antibodies immunoprecipitated 80K-H from cell lysates of FGF-stimulated but not from control fibroblasts .","gene":["anti-phosphotyrosine antibodies","80K-H"],"gene_indices_start":[14,65],"gene_indices_end":[45,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2526,"text":"Splice variations in genes coding for the transmembrane FGF receptor ( FGFR ) result in isoforms that vary in the ectodomain , intracellular juxtamembrane domain , and the intracellular kinase domain .","gene":["FGFR","transmembrane FGF receptor","intracellular kinase domain"],"gene_indices_start":[42,71,172],"gene_indices_end":[68,75,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2530,"text":"The enzymatic response of neutrophils and monocytes was similar although the magnitude of the NADPH oxidase activity was significantly higher in neutrophils than in monocytes .","gene":["NADPH oxidase"],"gene_indices_start":[94],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2531,"text":"These results suggest that beta-1 may act as a tissue-specific , trans-acting regulator of the expression of the beta-zein gene in developing maize endosperm .","gene":["beta-1","beta-zein gene"],"gene_indices_start":[27,113],"gene_indices_end":[33,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2532,"text":"Thus , through a change in conformation upon repair of the 6RG lesion , MGMT switches from a DNA repair factor to a transcription regulator ( R-MGMT ) , enabling the cell to sense as well as respond to mutagens .","gene":["MGMT","R-MGMT"],"gene_indices_start":[72,142],"gene_indices_end":[76,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2537,"text":"The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekanski or milk-ejection activity in vitro following van Dongen and Hays , respectively .","gene":["vasopressin","oxytocin"],"gene_indices_start":[21,37],"gene_indices_end":[32,45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2538,"text":"MK-927 : a topically active ocular hypotensive carbonic anhydrase inhibitor .","gene":["carbonic anhydrase"],"gene_indices_start":[47],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2540,"text":"We have cloned the single-copy gene for the trans -spliceosomal U5 snRNA from the trypanosomatid species Leptomonas seymouri , using U5 RNA affinity selection and cDNA cloning .","gene":["trans -spliceosomal U5 snRNA","U5 RNA"],"gene_indices_start":[44,133],"gene_indices_end":[72,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2541,"text":"In these experiments we begin to study the potential functions of the alpha 7 cytoplasmic domain by analyzing homologies between the rat and human sequences , by immunologic studies using an anti-cytoplasmic domain antiserum , and by identifying two alternate forms .","gene":["alpha 7 cytoplasmic domain"],"gene_indices_start":[70],"gene_indices_end":[96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2545,"text":"This analysis revealed an intact gene ( arg4 ) showing a high degree of homology with the Saccharomyces cerevisiae CPA2 gene encoding the large subunit of carbamoyl-phosphate synthetase ( CPS-A ) .","gene":["Saccharomyces cerevisiae CPA2 gene","carbamoyl-phosphate synthetase","CPS-A","arg4"],"gene_indices_start":[40,90,155,188],"gene_indices_end":[44,124,185,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2547,"text":"The effects of dominant interfering forms of the JNK \/ p38 signaling pathway demonstrate that activation of these kinases is critical for cytokine-induced E-selectin gene expression .","gene":["JNK \/ p38","E-selectin gene"],"gene_indices_start":[49,155],"gene_indices_end":[58,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2549,"text":"Mutations of the RET gene , encoding a receptor tyrosine kinase , have been associated with the inherited cancer syndromes MEN 2A and MEN 2B .","gene":["receptor tyrosine kinase","RET gene"],"gene_indices_start":[17,39],"gene_indices_end":[25,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2551,"text":"The topology and chain folding of the beta subunits in the artifactual beta 60 capsid are similar to the native alpha 3 beta 60 enzyme .","gene":["native alpha 3 beta 60 enzyme"],"gene_indices_start":[105],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2552,"text":"Northern blot analysis , using the Ltp4-specific probe , indicated that Xanthomonas campestris pv . translucens induced an increase over basal levels of Ltp4 mRNA , while Pseudomonas syringae pv . japonica caused a decrease .","gene":["Ltp4 mRNA"],"gene_indices_start":[153],"gene_indices_end":[162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2553,"text":"Together , these data identify ERK2 as a specific and direct target of HePTP and are consistent with a model in which HePTP negatively regulates ERK2 activity as part of a feedback mechanism .","gene":["HePTP","ERK2","HePTP","ERK2"],"gene_indices_start":[31,71,118,145],"gene_indices_end":[35,76,123,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2554,"text":"UV cross-linking experiments demonstrated that HSV infection caused enhanced binding of protein factors , including the 64-kDa component of cleavage stimulation factor ( CstF ) , to poly ( A ) site RNAs from virus genes of all temporal classes and that this enhanced binding required expression of IE63 .","gene":["64-kDa component of cleavage stimulation factor","IE63","CstF"],"gene_indices_start":[120,170,298],"gene_indices_end":[167,174,302],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2555,"text":"However , little was understood about the normal function of CREB-2 in mammalian development or organ physiology .","gene":["CREB-2"],"gene_indices_start":[61],"gene_indices_end":[67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2557,"text":"In order to gain deeper insight into the role of the amino-terminal domain of the p24 ( CA ) protein during viral replication , eight highly conserved proline residues known to promote turns and to terminate alpha-helices within the p24 tertiary structure were replaced by a leucine residue ( P-position-L ) .","gene":["p24","p24 ( CA )"],"gene_indices_start":[82,233],"gene_indices_end":[92,236],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2558,"text":"However , when directed to the nucleosome by fusion to core histone H2A or H2B , the non-histone tail forms an MCB that appears identical to that of the endogenous protein .","gene":["core histone H2A","H2B"],"gene_indices_start":[55,75],"gene_indices_end":[71,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2559,"text":"A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter .","gene":["aldolase B gene"],"gene_indices_start":[62],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2563,"text":"A cDNA clone was isolated from a chicken embryo cDNA library employing a PCR-generated radiolabeled probe specific for the U3 region of the Rous sarcoma virus LTR .","gene":["U3 region"],"gene_indices_start":[123],"gene_indices_end":[132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2564,"text":"Finally , there are a growing number of arguments favouring the use of ACE inhibitors very early in patients with diabetes mellitus .","gene":["ACE"],"gene_indices_start":[71],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2567,"text":"Transfection of HepG2 and SK-N-MC cells with constructs deleted of additional 5'-flanking fragments permitted the definition of a minimal 200 bp promoter fragment containing the pseudo-TATA box and two putative SP1-binding sites .","gene":["SP1-binding sites"],"gene_indices_start":[211],"gene_indices_end":[228],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2568,"text":"Comparison of cDNA and genomic sequences shows that the ZNF189 gene spans approximately 11 kb and is organized into at least four exons , the large 3'-end exon coding for the complete zinc finger domain and the 3' untranslated region .","gene":["ZNF189 gene"],"gene_indices_start":[56],"gene_indices_end":[67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2570,"text":"Mutations truncating as many as 143 C-terminal residues from the transcriptional activator encoded by the areA gene , mediating nitrogen metabolite repression in Aspergillus nidulans , do not significantly reduce the ability of the areA product to activate expression of most genes under areA control .","gene":["areA gene","areA product","areA"],"gene_indices_start":[106,232,288],"gene_indices_end":[115,244,292],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2571,"text":"However , we identified a gene between the MDV2 UL54 and UL55 genes with homology to the first ORF ( ORF-1 ) of equine herpesvirus type 1 and corresponding gene identified in pseudorabies virus .","gene":["UL55 genes","MDV2 UL54","ORF-1"],"gene_indices_start":[43,57,101],"gene_indices_end":[52,67,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2572,"text":"Using lectin-affinity chromatography , discordance between the pattern of O-glycosylation of SSBP and DSBP was demonstrated .","gene":["DSBP","SSBP"],"gene_indices_start":[93,102],"gene_indices_end":[97,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2574,"text":"Analysis of hematopoietic growth factor prescriptions in 19 french cancer centers .","gene":["hematopoietic growth factor"],"gene_indices_start":[12],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2576,"text":"By in vitro immunoprecipitations and gel shift assays , we identified two classes of high affinity Engrailed-binding sites upstream of each of the two polyhomeotic transcription units .","gene":["Engrailed-binding sites"],"gene_indices_start":[99],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2582,"text":"Nucleotide sequence analysis of the HA gene in these two mutants confirmed the HA- phenotype .","gene":["HA gene","HA-"],"gene_indices_start":[36,79],"gene_indices_end":[43,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2583,"text":"Characterization of FIII \/ YY1 , a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes .","gene":["FIII","YY1","L14 ribosomal protein genes","L1"],"gene_indices_start":[20,27,109,116],"gene_indices_end":[24,30,111,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2585,"text":"Corticosteroid-mediated transcriptional inhibition was greater for MR \/ GR in combination than for MR or GR alone .","gene":["MR \/ GR","GR","MR"],"gene_indices_start":[67,99,105],"gene_indices_end":[74,101,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2588,"text":"Interestingly , dTFIIA-L \/ S is also able to significantly enhance transcriptional activation by upstream transcription factors including Sp1 , VP16 , and NTF-1 .","gene":["VP16","Sp1","dTFIIA-L \/ S","NTF-1"],"gene_indices_start":[16,138,144,155],"gene_indices_end":[28,141,148,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2591,"text":"Prostate-specific antigen ( PSA ) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines .","gene":["Prostate-specific antigen","PSA","sodium iodide symporter"],"gene_indices_start":[0,28,83],"gene_indices_end":[25,31,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2592,"text":"In addition , npm3 , which is usually coactivated with fgf8 by MMTV insertion , was not up-regulated by androgens in SC-3 cells .","gene":["npm3","fgf8"],"gene_indices_start":[14,55],"gene_indices_end":[18,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2595,"text":"In flies , the dShc protein physically associates with the activated Drosophila epidermal growth factor receptor homolog ( DER ) and is inducibly phosphorylated on tyrosine by DER .","gene":["dShc protein","DER","Drosophila epidermal growth factor receptor homolog","DER"],"gene_indices_start":[15,69,123,176],"gene_indices_end":[27,120,126,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2598,"text":"Its cognate binding protein , REST \/ NRSF , is an essential transcription factor ; its null mutations result in embryonic lethality , and its dominant negative mutants produce aberrant expression of neuron-specific genes .","gene":["REST \/ NRSF"],"gene_indices_start":[30],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2599,"text":"These two repeat motifs are organized in an extremely well-ordered pattern in each domain , which suggests that SbHRGP3 belongs to a new group of proteins having the repeat motifs of two distinct groups of dicot extensins .","gene":["SbHRGP3","dicot extensins"],"gene_indices_start":[112,206],"gene_indices_end":[119,221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2600,"text":"Here , we show that the zinc finger protein Gis1 acts as a dosage-dependent suppressor of the rim15Delta defect in nutrient limitation-induced transcriptional derepression of SSA3 .","gene":["SSA3","rim15Delta","zinc finger protein Gis1"],"gene_indices_start":[24,94,175],"gene_indices_end":[48,104,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2601,"text":"Rho GDP \/ GTP exchange inhibitor , Rho GDI , comigrated with Rac2 and RhoA , but not Rac1 .","gene":["Rho GDP \/ GTP exchange inhibitor","Rac2","RhoA","Rac1","Rho GDI"],"gene_indices_start":[0,35,61,70,85],"gene_indices_end":[32,42,65,74,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2603,"text":"In this study , we have cloned the 5'-flanking region of the human nidogen gene .","gene":["human nidogen gene"],"gene_indices_start":[61],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2607,"text":"A statistically significant improvement due to the administration of Bromergon was observed in symptoms associated with overreactiveness to normal prolactin levels , i . e . abdominal tension , edema , weight gain and breast tenderness .","gene":["prolactin"],"gene_indices_start":[147],"gene_indices_end":[156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2608,"text":"Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus .","gene":["myotonic dystrophy locus","mouse WD-repeat gene DMR-N9"],"gene_indices_start":[68,124],"gene_indices_end":[95,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2609,"text":"Visual averaged evoked responses and platelet monoamine oxidase in patients suffering from alcoholism .","gene":["platelet monoamine oxidase"],"gene_indices_start":[37],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2612,"text":"In this study , evidence is presented that temporally and spatially specific mef2 expression is controlled by a complex array of cis-acting regulatory modules that are responsive to different genetic signals .","gene":["mef2"],"gene_indices_start":[77],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2613,"text":"BACKGROUND : We hypothesized that the postoperative serum level of TA90-IC , an immune complex of a 90-kDa tumor-associated antigen and its antibody , might have a significant correlation with recurrence and survival in patients with thick primary melanomas .","gene":["TA90-IC"],"gene_indices_start":[67],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2615,"text":"The present data also demonstrate that ectopic expression of blr1 increased JNK \/ SAPK activity , but JNK \/ SAPK activation was not needed for accelerated RA-induced differentiation and growth arrest .","gene":["JNK \/","blr1","SAPK","JNK \/ SAPK"],"gene_indices_start":[61,76,102,108],"gene_indices_end":[65,86,107,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2616,"text":"Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry .","gene":["human aminoacyl-tRNA synthetase complex","EMAPII domain"],"gene_indices_start":[17,34],"gene_indices_end":[30,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2617,"text":"To identify nuclear regulatory factors , we have located and functionally characterized the CCR5 gene promoter .","gene":["CCR5 gene promoter"],"gene_indices_start":[92],"gene_indices_end":[110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2619,"text":"The protein expressed by F2771 cDNA in transfected COS cells is localized in the cytoplasm .","gene":["F2771 cDNA"],"gene_indices_start":[25],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2621,"text":"Pax-3 is a paired-type homeobox gene that is specifically expressed in the dorsal and posterior neural tube .","gene":["Pax-3","paired-type homeobox gene"],"gene_indices_start":[0,11],"gene_indices_end":[5,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2628,"text":"Furthermore , transfection of cells with the spacer-RING domain alone suppressed the antiapoptotic function of the N-terminal BIR domain of c-IAP1 and induced apoptosis .","gene":["c-IAP1"],"gene_indices_start":[140],"gene_indices_end":[146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2630,"text":"N-terminal sequence analysis and NMR measurements revealed that this fragment originates from the C-terminal 80 residues of MBF1 and form a well structured C-terminal domain of MBF1 , MBF1CTD .","gene":["MBF1","MBF1","MBF1CTD"],"gene_indices_start":[124,177,184],"gene_indices_end":[128,181,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2631,"text":"Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription .","gene":["early growth response factor Egr-1","apolipoprotein AI gene"],"gene_indices_start":[15,53],"gene_indices_end":[49,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2635,"text":"Having an LRR domain and an SH3-binding domain , Acan125 and the C . elegans homologue define a novel family of bifunctional binding proteins .","gene":["SH3-binding domain","Acan125","LRR domain"],"gene_indices_start":[10,28,49],"gene_indices_end":[20,46,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2638,"text":"The Psc2 cDNA contained an open reading frame homologous to CP2 family proteins .","gene":["Psc2 cDNA","CP2 family proteins"],"gene_indices_start":[4,60],"gene_indices_end":[13,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2639,"text":"These data show that PTH and cAMP can repress collagen promoter activity in calvariae from transgenic mice , suggesting that the alpha 1 ( I ) collagen promoter may contain cis elements down-stream of -2 . 3 kilobases that mediate PTH and cAMP repression of collagen gene expression in bone .","gene":["PTH","collagen gene","PTH","alpha 1 ( I ) collagen promoter","collagen promoter"],"gene_indices_start":[21,46,129,231,258],"gene_indices_end":[24,63,160,234,271],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2640,"text":"Mean corpuscular hemoglobin concentrations remained normal for 48 h and then decreased in both groups , the CO2 group showing the larger decrease .","gene":["corpuscular hemoglobin"],"gene_indices_start":[5],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2642,"text":"Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo : possible relation to serotonin autoreceptor function .","gene":["serotonin autoreceptor"],"gene_indices_start":[140],"gene_indices_end":[162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2644,"text":"In contrast to the myoD promoter , the myoD enhancer shows striking conservation between humans and mice both in its sequence and its distal position .","gene":["myoD enhancer","myoD promoter"],"gene_indices_start":[19,39],"gene_indices_end":[32,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2645,"text":"Serum beta 2-microglobulin levels ( beta-2-M ) were studied in 150 drug addicts , 50 of them asymptomatic carriers of anti HIV-1 antibodies , 50 symptomatic carriers with persistent generalized lymphadenopathy ( P . G . L . ) and 50 serum negative patients who had been living in a closed community for at least 2 years .","gene":["anti HIV-1 antibodies","Serum beta 2-microglobulin","beta-2-M"],"gene_indices_start":[0,36,118],"gene_indices_end":[26,44,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2646,"text":"During challenge , rebiopsy was done when reticulin antibodies turned positive ( mean 0 . 6 years , range 0 . 2-2 . 0 ) or at the end of the two year study .","gene":["reticulin antibodies"],"gene_indices_start":[42],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2647,"text":"The Bacillus subtilis phage phi 105 repressor , a lambda repressor-like transcriptional regulatory protein , was overproduced in Escherichia coli and purified to near homogeneity in order to examine its in vitro DNA-binding properties .","gene":["protein","Bacillus subtilis phage phi 105 repressor","lambda"],"gene_indices_start":[4,50,99],"gene_indices_end":[45,56,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2649,"text":"We now show that regulation of flaN transcription in vivo depends on a sigma 54 promoter and two ftr elements located downstream of the transcription start site at +86 ( ftr2 ) and +120 ( ftr3 ) .","gene":["ftr2","ftr3","sigma 54 promoter","ftr elements","flaN"],"gene_indices_start":[31,71,97,170,188],"gene_indices_end":[35,88,109,174,192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2650,"text":"Subsequently , we show that the reexpression of the r-PTPeta gene in highly malignant rat thyroid cells transformed by retroviruses carrying the v-mos and v-ras-Ki oncogenes suppresses their malignant phenotype .","gene":["v-mos","r-PTPeta gene","v-ras-Ki oncogenes"],"gene_indices_start":[52,145,155],"gene_indices_end":[65,150,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2652,"text":"In vitro binding studies using GST fusion proteins and yeast extracts defined distinct binding sites on yAP180A for Pan1p and clathrin . yAP180 proteins and Pan1p , like actin , localize to peripheral patches along the plasma membrane .","gene":["Pan1p","yAP180A","clathrin","yAP180 proteins","actin","Pan1p","GST"],"gene_indices_start":[31,104,116,126,137,157,170],"gene_indices_end":[34,111,121,134,152,162,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2653,"text":"The availability of potent regulatory DNA cassettes harboring the murine D1A gene promoter could aid testing the neuronal-specific expression of transgenes in vivo .","gene":["murine D1A gene promoter"],"gene_indices_start":[66],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2656,"text":"We have identified in the 5' untranslated region of the Drosophila copia retrotransposon , 3' to the left LTR , a sequence for transcriptional regulation by homeoproteins .","gene":["Drosophila copia retrotransposon"],"gene_indices_start":[56],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2659,"text":"CM reduced the nuclear binding activity of transcription factor AP-1 .","gene":["transcription factor AP-1"],"gene_indices_start":[43],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2660,"text":"The SUP44 suppressor mutation occurs near a region of the protein that corresponds to the known positions of alterations in E . coli S5 ram mutations .","gene":["E . coli S5 ram mutations","SUP44 suppressor mutation"],"gene_indices_start":[4,124],"gene_indices_end":[29,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2661,"text":"The DNA sequence encodes a protein of 1520 amino acids with sequence homology to the human c-abl proto-oncogene product , beginning at the amino terminus and extending 656 amino acids through the region essential for tyrosine kinase activity .","gene":["tyrosine kinase","human c-abl proto-oncogene product"],"gene_indices_start":[85,217],"gene_indices_end":[119,232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2662,"text":"The expression pattern of GL2 , as demonstrated by in situ hybridization , indicated that the gene is expressed in trichome progenitor cells and at stages associated with trichome development .","gene":["GL2"],"gene_indices_start":[26],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2663,"text":"The amount of these factors was reduced in GEO cells in which the u-PAR gene is only weakly transcriptionally activated .","gene":["u-PAR gene"],"gene_indices_start":[66],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2664,"text":"Homozygous mutant mice , designated Cux \/ CDPDeltaCR1 , display a phenotype characterized by curly vibrissae and wavy hair .","gene":["Cux \/ CDPDeltaCR1"],"gene_indices_start":[36],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2665,"text":"In the 3' flanking region of the 27 kDa zein gene , several AATAAA-like sequences and a sequence resembling the mammalian GT-rich sequence are present around the polyadenylation sites .","gene":["27 kDa zein gene"],"gene_indices_start":[33],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2668,"text":"The qualitative concentrations of HCG had a sensitivity of 37 . 5% and a specificity of 100% .","gene":["HCG"],"gene_indices_start":[34],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2669,"text":"Mapping of RNA- temperature-sensitive mutants of Sindbis virus : complementation group F mutants have lesions in nsP4 .","gene":["nsP4","temperature-sensitive mutants of Sindbis virus : complementation group F mutants"],"gene_indices_start":[16,113],"gene_indices_end":[96,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2670,"text":"In addition to a previously characterized promoter ( P1 ) , we now show the existence of a second promoter for the human IL-5Ralpha gene .","gene":["human IL-5Ralpha gene","P1"],"gene_indices_start":[53,115],"gene_indices_end":[55,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2672,"text":"This approach was examined utilizing the fetal protein , HGB F .","gene":["HGB F"],"gene_indices_start":[57],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2674,"text":"The mouse M-lysozyme downstream enhancer has been previously characterized on several levels of gene regulation .","gene":["mouse M-lysozyme downstream enhancer"],"gene_indices_start":[4],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2675,"text":"This complex interacts at the GTPase domain in the large subunit rRNA , overlapping the binding site of the protein L11-like eukaryotic counterpart ( Saccharomyces cerevisiae protein L15 and mammalian protein L12 ) .","gene":["mammalian protein L12","protein L11-like eukaryotic counterpart","GTPase domain","large subunit rRNA","Saccharomyces cerevisiae protein L15"],"gene_indices_start":[30,51,108,150,191],"gene_indices_end":[43,69,147,186,212],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2676,"text":"Each patient had measurable LH and FSH levels , with pulsed nocturnal secretion , and pubertal LH and FSH responses to LRH .","gene":["LH","LH","LRH","FSH","FSH"],"gene_indices_start":[28,35,95,102,119],"gene_indices_end":[30,38,97,105,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2677,"text":"Using one of the six fragments ( CPK3-8 ) , we isolated a 2022 bp cDNA ( VrCDPK-1 ) from a Vigna radiata lambda gt11 library .","gene":["2022 bp cDNA ( VrCDPK-1 )","CPK3-8"],"gene_indices_start":[33,58],"gene_indices_end":[39,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2678,"text":"TIEG expression in hFOB cells was highly induced by TGF-beta and bone morphogenetic protein-2 ( BMP-2 ) , with a moderate induction by epidermal growth factor ( EGF ) , but no induction by other growth factors \/ cytokines was observed .","gene":["epidermal growth factor","TIEG","bone morphogenetic protein-2","BMP-2","TGF-beta","EGF"],"gene_indices_start":[0,52,65,96,135,161],"gene_indices_end":[4,60,93,101,158,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2679,"text":"Introduction of v-fms into a CSF-1 dependent murine macrophage cell line induced factor independence and tumorigenicity by a nonautocrine mechanism .","gene":["CSF-1","v-fms"],"gene_indices_start":[16,29],"gene_indices_end":[21,34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2683,"text":"The mRNA identified in both human and rat cells with the human clathrin clone revealed transcripts of approximately 6 . 5 kb , which is consistent with the predicted 180 kDa molecular weight of the clathrin heavy chain .","gene":["human clathrin","clathrin heavy chain"],"gene_indices_start":[57,198],"gene_indices_end":[71,218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2685,"text":"Analysis of mCTR mRNAs has revealed that the three alternative promoters give rise to at least seven mCTR isoforms in the 5' region of the gene and generate 5'-untranslated regions of very different lengths .","gene":["mCTR isoforms","mCTR mRNAs"],"gene_indices_start":[12,101],"gene_indices_end":[22,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2688,"text":"Expression of the CYP11A1 gene is increased by hormones , such as adrenocorticotropin and luteinizing hormone , as well as by a number of growth factors , suggesting that its promoter may contain regulatory elements that respond to multiple signal transduction pathways .","gene":["growth factors","luteinizing hormone","adrenocorticotropin","CYP11A1 gene"],"gene_indices_start":[18,66,90,138],"gene_indices_end":[30,85,109,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2689,"text":"Deletion analysis of the ICL1 promoter led to the identification of an upstream activating sequence element , UASICL1 ( 5' CATTCATCCG 3' ) , necessary and sufficient for conferring carbon source-dependent regulation on a heterologous reporter gene .","gene":["5' CATTCATCCG 3'","ICL1 promoter","UASICL1"],"gene_indices_start":[25,110,120],"gene_indices_end":[38,117,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2690,"text":"Cotransfections with ATF-2 and HNF-4 expression plasmids resulted in additive transactivation of the apoCIII promoter .","gene":["ATF-2","HNF-4","apoCIII promoter"],"gene_indices_start":[21,31,101],"gene_indices_end":[26,36,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2692,"text":"Once NGF administration is proven effective it will be possible to develop alternative ways of NGF administration .","gene":["NGF","NGF"],"gene_indices_start":[5,95],"gene_indices_end":[8,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2695,"text":"Sequence analysis of the zebrafish egr1 coding region revealed a high level of homology to the mouse , rat , and human Egr1 genes with the notable exception of a polymorphic , triplet nucleotide repeat sequence in the region coding for the amino terminus of the Egr1 protein .","gene":["zebrafish egr1 coding region","human Egr1 genes","Egr1 protein"],"gene_indices_start":[25,113,262],"gene_indices_end":[53,129,274],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2698,"text":"On the basis of these unique properties , the newly characterized hemagglutinin has been termed Limulus 18K agglutination-aggregation factor ( 18K-LAF ) .","gene":["hemagglutinin","18K-LAF","Limulus 18K agglutination-aggregation factor"],"gene_indices_start":[66,96,143],"gene_indices_end":[79,140,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2699,"text":"Products of immune cells such as transfer factor and lymphokines form the third and possibly most important group of immune-stimulating agents .","gene":["transfer factor"],"gene_indices_start":[33],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2705,"text":"Oligonucleotides , designed on the basis of conserved flanking amino acid sequence segments within the catalytic domain of eukaryotic protein kinase C ( PKC ) proteins , were used as primers for polymerase chain reactions to amplify a 427-bp chromosomal DNA fragment from the filamentous fungus Trichoderma reesei .","gene":["( PKC ) proteins","eukaryotic protein kinase C"],"gene_indices_start":[123,151],"gene_indices_end":[150,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2711,"text":"Toward this end , we prepared synthetic proteins with either the catalytic domain of FAP-1 ( C-terminal 399 amino acids ) or its inactive form ( Cys2408-- > Ser ) fused to glutathione-S-transferase ( GST ) .","gene":["GST","FAP-1 ( C-terminal 399 amino acids )","glutathione-S-transferase"],"gene_indices_start":[85,172,200],"gene_indices_end":[121,197,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2712,"text":"To investigate the mechanisms involved in the transcriptional control of retinoid X receptor ( RXR ) gene expression , the 5'-flanking region of the human RXRgamma2 isoform was characterized .","gene":["RXR","retinoid X receptor","human RXRgamma2 isoform"],"gene_indices_start":[73,95,149],"gene_indices_end":[92,98,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2713,"text":"The E1 gene is located within the first intron of the gene for RCC1 , a protein that regulates onset of mitosis .","gene":["E1 gene","RCC1"],"gene_indices_start":[4,63],"gene_indices_end":[11,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2715,"text":"Here we demonstrate that AML1a , which solely has no effects as a transcriptional regulator , dominantly suppresses transcriptional activation by AML1b , and that AML1a exhibits the higher affinity for DNA-binding than AML1b .","gene":["AML1b","AML1a","AML1a","AML1b"],"gene_indices_start":[25,146,163,219],"gene_indices_end":[30,151,168,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2718,"text":"A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE , i . e . the chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ) .","gene":["GlRE","chicken ovalbumin upstream promoter-transcription factor II","COUP-TFII"],"gene_indices_start":[99,118,180],"gene_indices_end":[103,177,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2719,"text":"SAPK \/ JNK activation was completely abolished in the absence of MKK7 , even though expression of MKK4 was strongly upregulated in mkk7 ( - \/ - ) mast cell lines , and phosphorylation of MKK4 occurred normally in response to multiple stress stimuli .","gene":["MKK7","mkk7 ( - \/ - )","MKK4","SAPK \/ JNK","MKK4"],"gene_indices_start":[0,65,98,131,187],"gene_indices_end":[10,69,102,145,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2720,"text":"In a PC12 cell mutant that is deficient in protein kinase A activity ( AB . 11 ) , all three differentiating agents were unable to down-regulate nrg-1 mRNA .","gene":["nrg-1 mRNA","protein kinase A"],"gene_indices_start":[43,145],"gene_indices_end":[59,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2721,"text":"Thus , the active-site mutation prevents the wild-type processing of the N-glycosylated 73-kDa precursor of PrB to the 41 . 5 kDa pro-PrB in the endoplasmic reticulum .","gene":["41 . 5 kDa pro-PrB","PrB"],"gene_indices_start":[108,119],"gene_indices_end":[111,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2723,"text":"The diabetic state was characterized by mild insulin deficiency , plasma levels being 73% of controls , and mild hyperglycemia , with nonfasting plasma glucose levels of 1 . 5 times normal .","gene":["insulin"],"gene_indices_start":[45],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2724,"text":"Acquired antithrombin deficiency in sepsis .","gene":["antithrombin"],"gene_indices_start":[9],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2726,"text":"Structural studies have shown that class I major histocompatibility complex ( MHC ) -restricted peptide-specific T cell receptor ( TCR ) -alpha \/ betas make multiple contacts with the alpha1 and alpha2 helices of the MHC , but it is unclear which or how many of these interactions contribute to functional binding .","gene":["MHC","MHC","peptide-specific T cell receptor ( TCR ) -alpha \/ betas","class I major histocompatibility complex"],"gene_indices_start":[35,78,96,217],"gene_indices_end":[75,81,151,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2730,"text":"The responsive region of the alpha 2 ( V ) collagen gene was localized to a fragment including 100 bp of basal promoter and 150 bp of exon 1 sequences , which contained two CRE-like elements .","gene":["alpha 2 ( V ) collagen gene","CRE-like elements"],"gene_indices_start":[29,173],"gene_indices_end":[56,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2731,"text":"Various mutant HN genes were constructed to examine the role of residues flanking the signal-anchor domain , including the cytoplasmic tail , on assembly and intracellular transport of the HN glycoprotein .","gene":["HN glycoprotein","mutant HN genes"],"gene_indices_start":[8,189],"gene_indices_end":[23,204],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2734,"text":"These findings suggest a novel ankyrin-independent role for LAD-1 related to FGFR signaling .","gene":["LAD-1","FGFR"],"gene_indices_start":[60,77],"gene_indices_end":[65,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2735,"text":"To facilitate the investigation of parameters that govern selective export in adenovirus-infected cells , we constructed a marked human beta-actin minigene under the control of the glucocorticoid-inducible enhancer-promoter of mouse mammary tumor virus and introduced it into the left end of the adenovirus type 5 ( Ad5 ) genome .","gene":["glucocorticoid-inducible enhancer-promoter","beta-actin minigene"],"gene_indices_start":[136,181],"gene_indices_end":[155,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2737,"text":"A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID .","gene":["transcription factor IID","human SPT3-TAFII31-GCN5-L acetylase complex"],"gene_indices_start":[2,60],"gene_indices_end":[45,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2739,"text":"We report here the identification of a cDNA that encodes a new member of the GTPase-activating protein ( GAP ) family of GTPase regulators .","gene":["GAP","GTPase-activating protein","GTPase"],"gene_indices_start":[77,105,121],"gene_indices_end":[102,108,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2740,"text":"In addition , CaMig1 formed specific complexes with the URS1 region of the S . cerevisiae FBP1 gene .","gene":["S . cerevisiae FBP1 gene","CaMig1","URS1 region"],"gene_indices_start":[14,56,75],"gene_indices_end":[20,67,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2741,"text":"New beta-blocking drugs have been introduced which may prove beneficial in certain clinical situations since they exert more selective blockade of the cardiac receptors ( beta1 ) as opposed to smooth muscle receptors ( beta2 ) .","gene":["smooth muscle receptors","beta1","cardiac receptors","beta2"],"gene_indices_start":[151,171,193,219],"gene_indices_end":[168,176,216,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2742,"text":"The nucleotide sequence alignment between mouse and human CA IV shows 69% identity in the coding region and all of the exon-intron boundaries are conserved , as are the sizes of the introns .","gene":["human CA IV"],"gene_indices_start":[52],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2743,"text":"The transcription factor Sp1 bound to eight sites , as demonstrated by footprinting assays and gel shift analysis with purified Sp1 .","gene":["Sp1","Sp1"],"gene_indices_start":[25,128],"gene_indices_end":[28,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2745,"text":"Structural changes in the C-terminus of Ca2+-bound rat S100B ( beta beta ) upon binding to a peptide derived from the C-terminal regulatory domain of p53 .","gene":["beta beta","rat S100B","p53"],"gene_indices_start":[51,63,150],"gene_indices_end":[60,72,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2752,"text":"These results indicate that TGF-betaf potentiates the c-fos SRE activated by PKC through the SRF binding site .","gene":["PKC","SRF binding site","SRE","c-fos","TGF-betaf"],"gene_indices_start":[28,54,60,77,93],"gene_indices_end":[37,59,63,80,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2753,"text":"By using a DNA sequence selected for its ability to bind recombinant BCL-6 in vitro , we show here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines .","gene":["BCL-6","recombinant BCL-6"],"gene_indices_start":[57,104],"gene_indices_end":[74,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2754,"text":"Here we demonstrate that the protein product of the ref-1 gene stimulates the DNA binding activity of Fos-Jun heterodimers , Jun-Jun homodimers and Hela cell AP-1 proteins as well as that of several other transcription factors including NF-kappa B , Myb and members of the ATF \/ CREB family .","gene":["NF-kappa B","Jun-Jun homodimers","Myb","ATF \/ CREB family","Fos-Jun heterodimers","ref-1 gene","AP-1 proteins"],"gene_indices_start":[52,102,125,158,237,250,273],"gene_indices_end":[62,122,143,171,247,253,290],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2757,"text":"Ki-ras4BVal-12 transfectant cells expressed 2-fold elevated protein levels of the lysosomal cysteine protease cathepsin B but did not up-regulate cathepsin B mRNA expression .","gene":["lysosomal cysteine protease cathepsin B","Ki-ras4BVal-12","cathepsin B mRNA"],"gene_indices_start":[0,82,146],"gene_indices_end":[14,121,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2758,"text":"Fgd3 and FGD1 share a high degree of sequence identity that spans > 560 contiguous amino acid residues .","gene":["FGD1","Fgd3"],"gene_indices_start":[0,9],"gene_indices_end":[4,13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2759,"text":"Conformational studies combining secondary structure predictions , CD and NMR spectroscopy together with ELISA assays , showed that the greater is the propensity of the epitope for helix formation the higher is the recognition by anti-K159 .","gene":["anti-K159"],"gene_indices_start":[230],"gene_indices_end":[239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2761,"text":"Gene 1 has been completely sequenced .","gene":["Gene 1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2767,"text":"Fenoldopam , a dopamine receptor agonist , has been shown , in animal experiments , to improve renal perfusion .","gene":["dopamine receptor"],"gene_indices_start":[15],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2768,"text":"Escherichia coli JRG582 is an ampD ampE deletion derivative of strain HfrH and accordingly it is derepressed for expression of the cloned inducible beta-lactamase gene of Citrobacter freundii , carried on plasmid pNU305 .","gene":["ampE","beta-lactamase gene","ampD"],"gene_indices_start":[30,35,148],"gene_indices_end":[34,39,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2770,"text":"Alginate biosynthesis is controlled by a complex regulatory mechanism .","gene":["Alginate"],"gene_indices_start":[0],"gene_indices_end":[8],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2774,"text":"Mutations in the nuclear gene CBP1 of Saccharomyces cerevisiae result in degradation of mitochondrially encoded cytochrome b ( cob ) RNA ; thus , the cells are unable to respire .","gene":["mitochondrially encoded cytochrome b","nuclear gene CBP1 of Saccharomyces cerevisiae","cob"],"gene_indices_start":[17,88,127],"gene_indices_end":[62,124,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2776,"text":"Results support the hypothesis that endogenous corticotropin-releasing factor , perhaps acting at a peripheral binding site , suppresses the active behavioral response characteristic of pups during the early phase of isolation in novel surroundings .","gene":["endogenous corticotropin-releasing factor"],"gene_indices_start":[36],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2777,"text":"TFEC , a basic helix-loop-helix protein , forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation .","gene":["TFE3","TFEC","basic helix-loop-helix protein"],"gene_indices_start":[0,9,66],"gene_indices_end":[4,39,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2778,"text":"Ly-49 is a family type II transmembrane proteins encoded by a gene cluster on murine chromosome 6 .","gene":["Ly-49","family type II transmembrane proteins"],"gene_indices_start":[0,11],"gene_indices_end":[5,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2779,"text":"Our results suggest that the crucial role of the mutations activating v-erbA as an oncogene is to 'freeze' c-ErbA \/ TRalpha in its non-liganded , repressive conformation and to facilitate its overexpression .","gene":["v-erbA","c-ErbA","TRalpha"],"gene_indices_start":[70,107,116],"gene_indices_end":[76,113,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2781,"text":"Adenyl cyclase activity of gastric mucosa in patients with duodenal ulcer before and after treatment .","gene":["Adenyl cyclase"],"gene_indices_start":[0],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2783,"text":"Comparison of beta 2-microglobulin removal using the same polysulphone membrane for haemodialysis and haemofiltration shows that beta 2-microglobulin is more effectively removed by convection than by diffusion when both treatment modes are matched for blood flow and urea clearance .","gene":["beta 2-microglobulin","beta 2-microglobulin"],"gene_indices_start":[14,129],"gene_indices_end":[34,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2784,"text":"The mice are phenotypically normal and do not develop spontaneous tumors at an early age , in contrast to knock-out ( p53 ( - \/ - ) ) strains with a defective p53 gene .","gene":["p53 gene","p53 ( - \/ - )"],"gene_indices_start":[118,159],"gene_indices_end":[131,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2787,"text":"Effect of succimer on the intensity of tricarboxylic acid dehydrogenase reactions in the brain of rats poisoned with mercuric chloride .","gene":["tricarboxylic acid dehydrogenase"],"gene_indices_start":[39],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2788,"text":"Our results suggest that the C-terminal region of Crk contains negative regulatory elements important for both Abl and FAK dependent signal pathways , and offers a paradigm for an autoinhibitory region in the SH3 linker \/ C-terminal SH3 domain .","gene":["Crk","SH3","SH3","Abl","FAK"],"gene_indices_start":[50,111,119,209,233],"gene_indices_end":[53,114,122,212,236],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2790,"text":"In contrast , mutations affecting the other two Nim1p-related kinases in S . cerevisiae , Hsl1p and Kcc4p , produce no detectable effect on septin organization .","gene":["septin","Nim1p-related kinases","Kcc4p","Hsl1p"],"gene_indices_start":[48,90,100,140],"gene_indices_end":[69,95,105,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2791,"text":"A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase .","gene":["DER receptor tyrosine kinase","Drosophila shc gene product"],"gene_indices_start":[2,64],"gene_indices_end":[29,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2793,"text":"Thus , blocks in the RARalpha-specific pathway of retinoid-induced differentiation may be bypassed during retinoid induction of FR-beta expression .","gene":["FR-beta"],"gene_indices_start":[128],"gene_indices_end":[135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2794,"text":"Once the proliferation of fibroblasts and collagen synthesis had led to an increase of mechanical strength , no negative effect on wound healing could be detected applying the same chemotherapeutic agents .","gene":["collagen"],"gene_indices_start":[42],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2798,"text":"Interestingly , the activity of IkappaB kinase ( IKK-beta ) , which plays an essential role in NF-kappaB activation through IkappaB phosphorylation , was largely enhanced in paclitaxel-treated cells , detected as IkappaBalpha phosphorylation .","gene":["IkappaBalpha","IKK-beta","IkappaB kinase","IkappaB","NF-kappaB"],"gene_indices_start":[32,49,95,124,213],"gene_indices_end":[46,57,104,131,225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2800,"text":"The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway , as a dominant-negative MEK and a MEK inhibitor ( PD98059 ) did not affect Rho-induced AP-1 activity .","gene":["MEK","dominant-negative MEK","mitogen-activated protein kinase pathway","Rho-induced AP-1","Rho","AP-1"],"gene_indices_start":[14,21,48,96,124,165],"gene_indices_end":[17,25,88,117,127,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2803,"text":"IFN-stimulated gene factor-3 and STAT1 homodimers formed and bound an IFN-stimulated response element ( ISRE ) and gamma-activated sequence ( GAS ) element , respectively .","gene":["STAT1 homodimers","gamma-activated sequence","IFN-stimulated gene factor-3","GAS","IFN-stimulated response element","ISRE"],"gene_indices_start":[0,33,70,104,115,142],"gene_indices_end":[28,49,101,108,139,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2805,"text":"ORF M1 has striking homology to poxvirus serpins , while ORF M11 encodes a potential homolog of Bcl-2-like molecules encoded by other gammaherpesviruses ( gene 16 of HVS and KSHV and the BHRF1 gene of EBV ) .","gene":["gene 16","Bcl-2-like molecules","serpins","ORF M11","ORF M1","BHRF1 gene"],"gene_indices_start":[0,41,57,96,155,187],"gene_indices_end":[6,48,64,116,162,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2806,"text":"A short sequence surrounding the major JNK phosphorylation site of c-Jun is conserved in c-Fos and is part of its activation domain , suggesting that c-Fos may be similarly regulated .","gene":["c-Fos","c-Jun","JNK","c-Fos"],"gene_indices_start":[39,67,89,150],"gene_indices_end":[42,72,94,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2810,"text":"Rapamycin ( FRAP \/ mTOR inhibitor ) blocked 4E-BP1 phosphorylation causing a predominance of the alpha ( hypophosphorylated ) band .","gene":["4E-BP1","FRAP","mTOR"],"gene_indices_start":[12,19,44],"gene_indices_end":[16,23,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2812,"text":"A unique leucine-proline repeat element found N-terminal to the DNA-binding domain of EmBP-1 does not appear to play a role in DNA-binding or dimerization .","gene":["EmBP-1","leucine-proline repeat element"],"gene_indices_start":[9,86],"gene_indices_end":[39,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2814,"text":"The PDE4A-subfamily-specific linker region LR1 , which joins UCR1 and UCR2 , is encoded by two exons , whereas LR2 , which joins UCR2 to the catalytic unit , is encoded by a single exon .","gene":["UCR2","LR1","UCR2","LR2","PDE4A-subfamily-specific linker region","UCR1"],"gene_indices_start":[4,43,61,70,111,129],"gene_indices_end":[42,46,65,74,114,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2818,"text":"Forskolin treatment ( 10 microM ) of the transfected cells for 3--6 h maximally induced luciferase threefold .","gene":["luciferase"],"gene_indices_start":[88],"gene_indices_end":[98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2822,"text":"The results also imply that the absence of perforin expression in non-cytotoxic cells may be due to the suppression of the induction of the killer-cell-specific trans-acting factor NF-P2 .","gene":["NF-P2","perforin"],"gene_indices_start":[43,181],"gene_indices_end":[51,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2825,"text":"To characterize the expression of this DNA repair enzyme , we have isolated the corresponding genomic clone .","gene":["DNA repair enzyme"],"gene_indices_start":[39],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2826,"text":"Serum gamma glutamyltransferase in the diagnosis of liver disease in cattle .","gene":["Serum gamma glutamyltransferase"],"gene_indices_start":[0],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2829,"text":"However , one CAK-phosphorylated phosphopeptide comigrates with a Cdc2-phosphorylated phosphopeptide previously shown to be mitosis-specific , suggesting that , in vitro , CAK is able to phosphorylate at least one site that is also phosphorylated in vivo .","gene":["CAK"],"gene_indices_start":[172],"gene_indices_end":[175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2833,"text":"Sequence analysis of the isolated genomic clone revealed that the DNA binding domain of this orphan receptor is most homologous to the human TR2 receptor .","gene":["orphan receptor","human TR2 receptor"],"gene_indices_start":[93,135],"gene_indices_end":[108,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2834,"text":"Interestingly , this amino-terminal determinant appears not to reside in the HSV-alpha TIF , which displays no independent amino-terminal activity .","gene":["TIF"],"gene_indices_start":[87],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2836,"text":"PFK-A mRNA was more abundantly expressed in all tissues than were the PFK-B and PFK-C genes .","gene":["PFK-B","PFK-A","PFK-C genes"],"gene_indices_start":[0,70,80],"gene_indices_end":[5,75,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2840,"text":"Analysis of the intact hGH gene or hGH 5'-flanking DNA ( 5'-FR ) coupled to the hGh cDNA or chloramphenicol acetyltransferase or luciferase genes , indicated that cAMP primarily stimulated hGH promoter activity .","gene":["hGH 5'-flanking DNA ( 5'-FR )","luciferase genes","hGh cDNA","hGH promoter","hGH gene","chloramphenicol acetyltransferase"],"gene_indices_start":[23,35,80,92,129,189],"gene_indices_end":[31,64,88,125,145,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2842,"text":"Clone 39 was a homolog of CONSTANS , which is a gene involved in controlling the flowering time in Arabidopsis .","gene":["CONSTANS"],"gene_indices_start":[26],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2843,"text":"Here we describe the identification and characterization of several Sp100 splice variant proteins and support their existence by elucidation of the 3'-end of the Sp100 gene .","gene":["Sp100 gene","Sp100 splice variant proteins"],"gene_indices_start":[68,162],"gene_indices_end":[97,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2844,"text":"Although linker regions in transcription factors are known to modulate DNA binding specificity , our studies suggest that the human HSF1 linker plays no role in determining HSF1 binding preferences in vivo but is a critical determinant in regulating the HSF1 monomer-trimer equilibrium .","gene":["HSF1 monomer-trimer","HSF1","human HSF1"],"gene_indices_start":[126,173,254],"gene_indices_end":[136,177,273],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2845,"text":"They also negatively modulate the PI 3-kinase catalytic activity but to different extents , dependent on the unique N-terminal structure of each isoform .","gene":["PI 3-kinase"],"gene_indices_start":[34],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2846,"text":"We conclude that the 'morning dip' observed in asthmatic patients cannot simply be explained by changes in cell receptor number or affinity , as our results suggest that both groups have intact beta-adrenoceptor function .","gene":["beta-adrenoceptor"],"gene_indices_start":[194],"gene_indices_end":[211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2850,"text":"The divergence in primary structure between the sheep CRF1 and the other mammalian CRF1s is primarily localized to the extracellular amino terminal domain of the receptor ( 18 of 22 divergent residues , ovine vs human CRF1 ) .","gene":["CRF1","human CRF1","mammalian CRF1s"],"gene_indices_start":[54,73,212],"gene_indices_end":[58,88,222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2851,"text":"Localization of the cytokine response element by 5'-deletion analysis and site-directed mutagenesis revealed a cis-acting binding site for activated STAT complexes .","gene":["cytokine response element","STAT complexes"],"gene_indices_start":[20,149],"gene_indices_end":[45,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2852,"text":"Comparison of human and murine blk sequences indicated that they share 86% amino acid identity , the most conserved region being the catalytic domain ( 93% identity ) .","gene":["human and murine blk sequences"],"gene_indices_start":[14],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2854,"text":"Members of the Ras subfamily of small GTP-binding proteins have been shown to be promiscuous towards a variety of putative effector molecules such as the protein kinase c-Raf and the Ral-specific guanine nucleotide exchange factor ( Ral-GEF ) .","gene":["small GTP-binding proteins","protein kinase c-Raf","Ras subfamily","Ral-GEF","Ral-specific guanine nucleotide exchange factor"],"gene_indices_start":[15,32,154,183,233],"gene_indices_end":[28,58,174,230,240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2855,"text":"Targeted disruption of the OGG1 gene in yeast revealed a second OG glycosylase \/ lyase protein , tentatively named Ogg2 , which differs from Ogg1 in that it preferentially acts on OG : G .","gene":["OGG1 gene","Ogg1","OG glycosylase \/ lyase protein","Ogg2"],"gene_indices_start":[27,64,115,141],"gene_indices_end":[36,94,119,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2856,"text":"Characterization of the regulatory regions of the human aromatase ( P450arom ) gene involved in placenta-specific expression .","gene":["P450arom","human aromatase"],"gene_indices_start":[50,68],"gene_indices_end":[65,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2857,"text":"Ectopic expression of Apo-3 in HEK293 or HeLa cells induced marked apoptosis .","gene":["Apo-3"],"gene_indices_start":[22],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2859,"text":"Regulation of RhoA is required to maintain adhesion in stationary cells , but is also critical for cell spreading and migration [ 3 ] .","gene":["RhoA"],"gene_indices_start":[14],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2861,"text":"DNase I footprinting of the proximal promoter revealed four regions of protection .","gene":["DNase I"],"gene_indices_start":[0],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2862,"text":"Atmospheric benzene , urinary muconic acid ( tt-MA ) and leukocyte alkaline phosphatase activity ( LAPA ) were evaluated among 66 car mechanics , 34 road tanker drivers , and 28 nonexposed workers .","gene":["leukocyte alkaline phosphatase"],"gene_indices_start":[57],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2865,"text":"In the present study , we have investigated the functional role of the other MAP kinases in PDGF-mediated cellular responses .","gene":["MAP kinases"],"gene_indices_start":[77],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2871,"text":"Disruption of the HOG1 and PBS2 genes leads to a dramatic decrease of the HSP12 inducibility in osmostressed cells , whereas overproduction of Hog1 produces a fivefold increase in wild-type induced levels upon a shift to a high salt concentration .","gene":["HSP12","Hog1","HOG1","PBS2 genes"],"gene_indices_start":[18,27,74,143],"gene_indices_end":[22,37,79,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2872,"text":"Human Duo contains a guanine nucleotide exchange factor ( GEF ) domain that is likely to be rac1-specific , a pleckstrin homology ( PH ) domain and spectrin-like repeat units .","gene":["spectrin-like repeat units","pleckstrin homology","Human Duo","GEF","PH","guanine nucleotide exchange factor"],"gene_indices_start":[0,21,58,110,132,148],"gene_indices_end":[9,55,61,129,134,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2877,"text":"Physical analysis maps SAL6 to chromosome XVI between TPK2 and spt14 .","gene":["TPK2","spt14","SAL6"],"gene_indices_start":[23,54,63],"gene_indices_end":[27,58,68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2879,"text":"Role of the 3' untranslated region of baculovirus p10 mRNA in high-level expression of foreign genes .","gene":["baculovirus p10 mRNA"],"gene_indices_start":[38],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2880,"text":"The three isoforms purified with anti-FLAG antibody affinity column transferred sulfate to heparan sulfate and heparin but not to other glycosaminoglycans .","gene":["anti-FLAG antibody"],"gene_indices_start":[33],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2881,"text":"Cloning and expression of a specific human alpha 1 , 2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis .","gene":["human alpha 1 , 2-mannosidase"],"gene_indices_start":[37],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2882,"text":"Higher fasting serum gastrin concentration ( 102 . 0 + \/ - 21 . 1 vs 63 . 3 + \/ - 8 . 3 ng . l-1 ) , and greater postprandial gastrin release ( AUC0-120 : 16690 + \/ - 2648 vs 10654 + \/ - 1283 ng . l-1 min ) were observed after VTP-HM than after VTP-Cas .","gene":["gastrin","gastrin"],"gene_indices_start":[21,126],"gene_indices_end":[28,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2883,"text":"Second , the transcription factor Gal-ER was rendered more potent and less susceptible to cell type-specific variation by fusing the strong activating domain of the herpesvirus protein VP16 onto its C terminus .","gene":["herpesvirus protein VP16","transcription factor Gal-ER"],"gene_indices_start":[13,165],"gene_indices_end":[40,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2885,"text":"VDR \/ RXR bound well to the VDREs and to DR4 and DR5 using the electrophoretic mobility shift assay .","gene":["VDREs","DR5","DR4","VDR \/ RXR"],"gene_indices_start":[0,28,41,49],"gene_indices_end":[9,33,44,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2888,"text":"Furthermore , beta 2-adrenoceptor sensitivity appears to be unaltered in BHT .","gene":["beta 2-adrenoceptor"],"gene_indices_start":[14],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2891,"text":"HYPOTHESIS : The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris .","gene":["apolipoprotein B-containing lipoproteins"],"gene_indices_start":[86],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2893,"text":"Further , Ser \/ Thr phosphorylation of downstream molecules Akt and p70 S6 kinase was inhibited .","gene":["p70 S6 kinase","Akt"],"gene_indices_start":[60,68],"gene_indices_end":[63,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2894,"text":"The cloning of PTR2 represents the first example of the molecular genetic characterization of a eucaryotic peptide transport gene .","gene":["PTR2"],"gene_indices_start":[15],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2897,"text":"Liver microsomes of the shag showed smaller than 8% of the epoxide hydrase activity and smaller than 14% of the hydroxylating capacity of liver microsomes from the rat .","gene":["epoxide hydrase"],"gene_indices_start":[59],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2898,"text":"Deletion analysis of rOC promoter-chloramphenicol acetyltransferase constructs demonstrates that an AML-1-binding sequence within the proximal promoter ( -138 to -130 nt ) contributes to 75% of the level of osteocalcin gene expression .","gene":["osteocalcin gene","AML-1-binding sequence","rOC promoter-chloramphenicol acetyltransferase constructs"],"gene_indices_start":[21,100,207],"gene_indices_end":[78,122,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2899,"text":"Recently , it was shown that purified RAG1 \/ 2 proteins can cleave DNA hairpins in vitro , but the same activity was also described for a protein complex of the DNA repair proteins Nbs1 \/ Mre11 \/ Rad50 .","gene":["RAG1 \/ 2 proteins","DNA repair proteins Nbs1 \/ Mre11 \/ Rad50"],"gene_indices_start":[38,161],"gene_indices_end":[55,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2901,"text":"Our studies extend these findings and show that the E2 transactivation gene is expressed from multiple promoters .","gene":["E2 transactivation gene"],"gene_indices_start":[52],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2902,"text":"Expression of a hybrid protein containing the cytoplasmic C-terminal half of UhpB fused to glutathione S-transferase ( GST ) also interfered with Uhp signaling .","gene":["glutathione S-transferase","Uhp","GST","UhpB"],"gene_indices_start":[77,91,119,146],"gene_indices_end":[81,116,122,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2904,"text":"The sequence of the HIR1 gene predicts an 88-kDa protein with three repeats of a motif found in the G beta subunit of retinal transducin and in a yeast transcriptional repressor , Tup1 .","gene":["retinal transducin","Tup1","G beta subunit","HIR1 gene"],"gene_indices_start":[20,100,118,180],"gene_indices_end":[29,114,136,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2905,"text":"65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites .","gene":["interleukin 2","actin-binding sites"],"gene_indices_start":[40,85],"gene_indices_end":[53,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2906,"text":"The murine mutation dominant white spotting ( W ) is in the proto-oncogene , c-kit .","gene":["W","murine mutation dominant white spotting","c-kit"],"gene_indices_start":[4,46,77],"gene_indices_end":[43,47,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2907,"text":"Protein kinase C ( PKC ) , a widely-distributed enzyme implicated in the regulation of many physiological processes , consists of a family of at least twelve isoenzymes which differ in tissue distribution , subcellular localization , regulatory properties , etc .","gene":["Protein kinase C","PKC"],"gene_indices_start":[0,19],"gene_indices_end":[16,22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2908,"text":"Therefore , the rbcL-rbcS locus seems to be barely expressed under a standard condition for photoautotrophic growth .","gene":["rbcL-rbcS locus"],"gene_indices_start":[16],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2909,"text":"In particular , the S1' specificity site is a deep and highly hydrophobic cavity .","gene":["S1' specificity site"],"gene_indices_start":[20],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2911,"text":"In broken L-cell membranes expressing wild type or mutant M6P \/ IGF II receptors , 30 nM IGF II also failed to affect the pertussis toxin substrate activity .","gene":["IGF II","wild type or mutant M6P \/ IGF II receptors","pertussis toxin"],"gene_indices_start":[38,89,122],"gene_indices_end":[80,95,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2912,"text":"NF-HB ( BSAP ) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation .","gene":["NF-HB","BSAP","murine immunoglobulin heavy-chain 3' alpha enhancer"],"gene_indices_start":[0,8,37],"gene_indices_end":[5,12,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2913,"text":"We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 ( p38 gamma ) , a recently identified member of the p38 family of MAPKs .","gene":["ERK6","MAPKs","RhoA","p38 family","p38 gamma"],"gene_indices_start":[14,85,92,142,156],"gene_indices_end":[18,89,101,152,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2914,"text":"Granulocyte colony-stimulating factor ( G-CSF ) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes .","gene":["G-CSF","Granulocyte colony-stimulating factor"],"gene_indices_start":[0,40],"gene_indices_end":[37,45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2915,"text":"Exposure to higher TPA concentrations decreased the content of these transcripts .","gene":["TPA"],"gene_indices_start":[19],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2920,"text":"Comparison of the sequences of attP , attB and bacteria-prophage junctions attL and attR showed a 26 bp common core sequence , where recombination takes place , near the 5' end of the integrase gene .","gene":["integrase gene","attB","attR","attL","attP"],"gene_indices_start":[31,38,75,84,184],"gene_indices_end":[35,42,79,88,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2921,"text":"This revealed a minimum of six novel OSBP-related proteins , designated ORP-1 to ORP-6 .","gene":["OSBP-related proteins","ORP-6","ORP-1"],"gene_indices_start":[37,72,81],"gene_indices_end":[58,77,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2924,"text":"We have been studying the interaction of the oncogenic human polyomavirus BK ( BKV ) with the tumor-suppressor protein p53 to understand the biology of this virus as well as to understand the basic mechanisms of p53 transactivation .","gene":["tumor-suppressor protein p53","p53"],"gene_indices_start":[94,212],"gene_indices_end":[122,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2926,"text":"This report substantiates that at least two of the 18 kDa hsps in maize are products of different but related genes .","gene":["hsps"],"gene_indices_start":[58],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2927,"text":"The novel hematopoietic growth factor FLT3 ligand ( FL ) is the cognate ligand for the FLT3 , tyrosine kinase receptor ( R ) , also referred to as FLK-2 and STK-1 .","gene":["STK-1","tyrosine kinase receptor","FL","FLK-2","hematopoietic growth factor FLT3 ligand","R","FLT3"],"gene_indices_start":[10,52,87,94,121,147,157],"gene_indices_end":[49,54,91,118,122,152,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2929,"text":"The Mif1 5' flanking region contains a functional ER stress-responsive element which is sufficient for induction by tunicamycin .","gene":["ER stress-responsive element","Mif1 5' flanking region"],"gene_indices_start":[4,50],"gene_indices_end":[27,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2930,"text":"After infection of 293 cells ( which provide complementary E1a-E1b functions ) , both viruses directed equal amounts of P \/ C-specific mRNA transcription .","gene":["E1a-E1b","P \/ C-specific mRNA"],"gene_indices_start":[59,120],"gene_indices_end":[66,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2932,"text":"To determine what role eIF4E might play in c-myc expression , the c-myc 5' untranslated region ( UTR ) was fused in-frame to CAT reporters , and several more derivative constructs were made .","gene":["eIF4E","CAT reporters","c-myc","c-myc 5' untranslated region ( UTR )"],"gene_indices_start":[23,43,66,125],"gene_indices_end":[28,48,102,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2935,"text":"Mycotoxins in feeds and foods .","gene":["Mycotoxins"],"gene_indices_start":[0],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2937,"text":"Comparative studies of the antithrombin III level and plasminogen activator activity in patients with thrombophlebitis .","gene":["plasminogen activator","antithrombin III"],"gene_indices_start":[27,54],"gene_indices_end":[43,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2938,"text":"Thus , YMIP is a functional homolog of RMIP and represents a new component of the yeast mitochondrial import machinery .","gene":["RMIP","YMIP"],"gene_indices_start":[7,39],"gene_indices_end":[11,43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2942,"text":"Mutation of Enh4 , an essential GT-IIC-like enhanson in the context of the intact enhancer , abolishes silencer activity , and multimerized GT-IIC enhansons mimic the intact CSEn enhancer \/ silencer activities in BeWo and GC cells , respectively .","gene":["Enh4","GT-IIC-like enhanson","GT-IIC enhansons","CSEn enhancer \/ silencer"],"gene_indices_start":[12,32,140,174],"gene_indices_end":[16,52,156,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2943,"text":"The complete gene organization was obtained by combining the results of the sequence of these clones and those of the characterization of polymerase chain reaction-amplified genomic segments .","gene":["polymerase"],"gene_indices_start":[138],"gene_indices_end":[148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2944,"text":"The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains .","gene":["dopamine D4 receptor","SH3 binding domains","catecholaminergic receptors"],"gene_indices_start":[4,47,100],"gene_indices_end":[24,74,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2951,"text":"Almost complete sequence identity was found between the 3' end of the DXS6673E gene and two expressed sequence tags ( ESTs ) and between the 5' end of the DXS6673E gene and a third EST .","gene":["DXS6673E gene","DXS6673E gene"],"gene_indices_start":[70,155],"gene_indices_end":[83,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2953,"text":"The rate-limiting step for telomerase activity seems to be the expression of the catalytic subunit of the enzyme , encoded by the human telomerase reverse transcriptase ( hTERT ) gene .","gene":["telomerase","human telomerase reverse transcriptase","hTERT"],"gene_indices_start":[27,130,171],"gene_indices_end":[37,168,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2954,"text":"Characterization of the 5'-flanking region of the human multidrug resistance protein 2 ( MRP2 ) gene and its regulation in comparison withthe multidrug resistance protein 3 ( MRP3 ) gene .","gene":["MRP3","human multidrug resistance protein 2","multidrug resistance protein 3","MRP2"],"gene_indices_start":[50,89,142,175],"gene_indices_end":[86,93,172,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2955,"text":"Epstein-Barr virus ( EBV ) latent membrane protein 1 ( LMP1 ) is essential for EBV-mediated transformation of primary B lymphocytes .","gene":["Epstein-Barr virus ( EBV ) latent membrane protein 1","LMP1"],"gene_indices_start":[0,55],"gene_indices_end":[52,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2956,"text":"Regulation of parathyroid hormone-related protein ( PTHrP ) gene expression .","gene":["parathyroid hormone-related protein","PTHrP"],"gene_indices_start":[14,52],"gene_indices_end":[49,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2957,"text":"Taken together , our data suggest that the antagonistic effects of CRP and KdgR on the expression of the pectinolysis genes occur by different mechanisms , including direct competition between the two regulators or between the repressor and RNA polymerase for the occupation of a common DNA region on the target genes .","gene":["RNA polymerase","CRP","pectinolysis genes","KdgR"],"gene_indices_start":[67,75,105,241],"gene_indices_end":[70,79,123,255],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2958,"text":"In a gntR deletion mutant , the expression of a chromosomal gntT : : lacZ fusion is both high and constitutive , confirming that GntR is the negative regulator of gntT .","gene":["gntT","GntR","chromosomal gntT : : lacZ fusion","gntR deletion mutant"],"gene_indices_start":[5,48,129,163],"gene_indices_end":[25,80,133,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2959,"text":"Consistent with the protein expression data , V beta 8 . 3 gene transcripts were found only in the transgenic lines with the wild-type promoter .","gene":["V beta 8 . 3 gene transcripts"],"gene_indices_start":[46],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2960,"text":"These synergistic effects were strongly Jem-1 dose-dependent .","gene":["Jem-1"],"gene_indices_start":[40],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2965,"text":"An activation-responsive element in single C motif-1 \/ lymphotactin promoter is a site of constitutive and inducible DNA-protein interactions involving nuclear factor of activated T cell .","gene":["single C motif-1","lymphotactin"],"gene_indices_start":[36,55],"gene_indices_end":[52,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2966,"text":"TNF Treatment of cell activated the p38 MAP kinase pathway , as revealed by increased phosphorylation of p38 MAP kinase itself , activation of the substrate protein MAPKAP kinase-2 , and culminating in the phosphorylation of the heat shock protein 27 ( hsp27 ) .","gene":["MAPKAP kinase-2","p38 MAP kinase","hsp27","heat shock protein 27","p38 MAP kinase"],"gene_indices_start":[36,105,165,229,253],"gene_indices_end":[50,119,180,250,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2970,"text":"We have isolated and sequenced the gene encoding the human U1-70K snRNP protein .","gene":["human U1-70K snRNP protein"],"gene_indices_start":[53],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2972,"text":"We found that the gene segment containing the mu m poly ( A ) signals , along with 536 bp of downstream flanking sequence , acted as a transcription terminator in both myeloma cells and L cell fibroblasts .","gene":["mu m poly ( A ) signals"],"gene_indices_start":[46],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2973,"text":"These results continue to support the hypothesis that HS2 , HS3 , and HS4 act as a single , integral unit to regulate human globin gene transcription as a holocomplex , but they can also be interpreted to say that formation of a DNase I hypersensitive holocomplex alone is not sufficient for mediating high-level globin gene transcription .","gene":["HS3","DNase I","globin gene","human globin gene","HS2","HS4"],"gene_indices_start":[54,60,70,118,229,313],"gene_indices_end":[57,63,73,135,236,324],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2974,"text":"Ischemia and reperfusion markedly increased the release of 6-keto-PGF1 alpha and TXB2 .","gene":["TXB2","6-keto-PGF1 alpha"],"gene_indices_start":[59,81],"gene_indices_end":[76,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2977,"text":"In addition , we observe that the hUBF-promoter interaction is highly sensitive to the antagonistic effects of cisplatin-DNA adducts .","gene":["hUBF-promoter"],"gene_indices_start":[34],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2978,"text":"Using the two-hybrid system , we show that nonprenylated Rac1 interacts very weakly with Rho-GDI , pointing to the predominant role of protein-isoprene interaction in complex formation .","gene":["Rho-GDI","Rac1"],"gene_indices_start":[57,89],"gene_indices_end":[61,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2980,"text":"This open reading frame was confirmed the correct one by direct amino-terminal sequence analysis of the overproduced msgB gene product .","gene":["msgB gene product"],"gene_indices_start":[117],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2982,"text":"Site-directed mutagenesis of the traI structural gene and application of purified mutant TraI proteins for in vitro assays served to evaluate the functional importance of conserved amino acid residues .","gene":["TraI proteins","traI structural gene"],"gene_indices_start":[33,89],"gene_indices_end":[53,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2983,"text":"This indicates that the mechanism by which CX blocks rapid degradation of tubulin mRNA in vivo is not simply by preventing its translation and suggests the involvement of an altered trans-factor .","gene":["tubulin mRNA"],"gene_indices_start":[74],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2986,"text":"The protein product of orfD , which is probably a new tra gene ( named traX ) , contains 65% hydrophobic amino acids , especially rich in alanine and leucine .","gene":["orfD","traX","tra gene"],"gene_indices_start":[23,54,71],"gene_indices_end":[27,62,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2987,"text":"Members of the titin \/ myosin light chain kinase family play an essential role in the organization of the actin \/ myosin cytoskeleton , especially in sarcomere assembly and function .","gene":["titin","myosin light chain kinase"],"gene_indices_start":[15,23],"gene_indices_end":[20,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2988,"text":"Purified Hsk1 phosphorylates the Cdc19 ( Mcm2 ) subunit of the six-member minichromosome maintenance protein complex purified from fission yeast .","gene":["Cdc19","Hsk1","Mcm2","six-member minichromosome maintenance protein complex"],"gene_indices_start":[9,33,41,63],"gene_indices_end":[13,38,45,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2989,"text":"In these vectors the chimeric long terminal repeat ( chLTR ) drives the expression of the chloramphenicol acetyl transferase ( CAT ) reporter gene that is followed by an internal SV40 virus early region promoter linked to the neomycin phosphotransferase II ( NEO ) gene .","gene":["NEO","CAT","neomycin phosphotransferase II","chloramphenicol acetyl transferase"],"gene_indices_start":[90,127,226,259],"gene_indices_end":[124,130,256,262],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2990,"text":"A second peptide ( amino acids 58-77 ) also antagonized p21-activity , but this peptide did not affect the ability of p21 to interact with cyclin E \/ Cdk2 .","gene":["p21","cyclin E \/ Cdk2"],"gene_indices_start":[118,139],"gene_indices_end":[121,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2992,"text":"Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding , enzyme-guanylate formation , and GMP transfer to RNA .","gene":["mRNA capping enzyme"],"gene_indices_start":[23],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2993,"text":"Preferential heterodimeric parallel coiled-coil formation by synthetic Max and c-Myc leucine zippers : a description of putative electrostatic interactions responsible for the specificity of heterodimerization .","gene":["synthetic Max","c-Myc leucine zippers"],"gene_indices_start":[61,79],"gene_indices_end":[74,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2995,"text":"Unlike p59v-rel , which is a nuclear protein in CEF , indirect immunofluorescence showed that p68c-rel in JD214c-rel infected CEF is located exclusively in the cytoplasm of these cells , even though the sequence of p68c-rel showed that it contains a nuclear localizing sequence identical to the one previously identified in p59v-rel .","gene":["p68c-rel","p59v-rel","p68c-rel","p59v-rel"],"gene_indices_start":[7,94,215,324],"gene_indices_end":[15,102,223,332],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2996,"text":"In addition , depletion of Oct-1 from the nuclear extract by using Oct-1-specific antiserum or a sequence-specific DNA affinity resin decreased in vitro transcription from the wild-type MMTV promoter to a level identical to that obtained from a promoter in which all three octamer-related sequences were mutated .","gene":["Oct-1"],"gene_indices_start":[27],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2998,"text":"Although diagnostic laparoscopy is still considered the standard reference in the diagnosis of ectopic pregnancy ( EP ) , use of high-resolution endovaginal sonography , in conjunction with qualitative serum assays of the beta subunit of human chorionic gonadotropin ( beta-hCG ) , allows detection of earlier and smaller EPs .","gene":["beta-hCG","human chorionic gonadotropin"],"gene_indices_start":[238,269],"gene_indices_end":[266,277],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3004,"text":"Our results suggest that Lrp binds a central palindromic site , interacting predominantly with the major groove of its DNA target , and that additional dimers bind to flanking sites to form a nucleoprotein activation complex .","gene":["Lrp"],"gene_indices_start":[25],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3009,"text":"Polypyrimidine and ssDNA binding by the isolated VH domain of immunization-induced anti-Z-DNA Ab resembles the activity of natural autoantibodies and suggests that VH-dependent binding to a ligand mimicked by polypyrimidines may play a role in B cell selection before immunization with Z-DNA .","gene":["anti-Z-DNA Ab","VH domain"],"gene_indices_start":[49,83],"gene_indices_end":[58,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3010,"text":"Likewise , rad6-delta reduces silencing of the telomere-located RNAP II-transcribed genes URA3 and ADE2 .","gene":["ADE2","telomere-located RNAP II-transcribed genes URA3","rad6-delta"],"gene_indices_start":[11,47,99],"gene_indices_end":[21,94,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3011,"text":"In this report we studied the role of protein-tyrosine phosphatase SHP-2 in ErbB-mediated activation of mitogen-activated protein kinase ( MAPK ) by overexpressing SHP-2 mutants in COS-7 cells .","gene":["protein-tyrosine phosphatase","SHP-2","SHP-2 mutants","mitogen-activated protein kinase","MAPK"],"gene_indices_start":[38,67,104,139,164],"gene_indices_end":[66,72,136,143,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3012,"text":"I hypothesize that white gene expression from P [ en ] is repressed by the formation of a protein complex which is initiated at the engrailed PS sites and also requires interactions with flanking genomic DNA .","gene":["engrailed PS sites","white gene"],"gene_indices_start":[19,132],"gene_indices_end":[29,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3015,"text":"These genes encode a tryptophanyl tRNA , the protein translocase component SecE , the antiterminator protein NusG , and the ribosomal proteins L11 and L1 in addition to PkwR , a putative regulatory protein of the LacI-GalR family .","gene":["LacI-GalR family","PkwR","ribosomal proteins L11 and L1","SecE","antiterminator protein NusG","tryptophanyl tRNA","protein translocase"],"gene_indices_start":[21,45,75,86,124,169,213],"gene_indices_end":[38,64,79,113,153,173,229],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3016,"text":"The Caenorhabditis elegans vitellogenin genes are subject to sex- , stage- , and tissue-specific regulation : they are expressed solely in the adult hermaphrodite intestine .","gene":["Caenorhabditis elegans vitellogenin genes"],"gene_indices_start":[4],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3018,"text":"Hypercalcemia associated with elevated serum PTH concentration indicating primary hyperparathyroidism was found in 7 BC patients ( 7% ) and in none of healthy women or patients with thyroid cancer .","gene":["serum PTH"],"gene_indices_start":[39],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3024,"text":"Metabolic labeling studies in S . cerevisiae and co-expression of nmt72p with several protein substrates of Nmt1p in Escherichia coli indicate that the Leu99-- > Pro substitution causes a reduction in the acylation of some but not all protein substrates .","gene":["nmt72p","Nmt1p"],"gene_indices_start":[66,108],"gene_indices_end":[72,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3025,"text":"G-CSF activates multiple signaling molecules , including the JAK1 and JAK2 kinases and the STAT transcription factors .","gene":["G-CSF","JAK2 kinases","STAT","JAK1"],"gene_indices_start":[0,61,70,91],"gene_indices_end":[5,65,82,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3030,"text":"Retroviral nucleocapsid proteins ( NCPs ) are CCHC-type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation .","gene":["NCPs","Retroviral nucleocapsid proteins","CCHC-type zinc finger proteins"],"gene_indices_start":[0,35,46],"gene_indices_end":[32,39,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3031,"text":"Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells .","gene":["CArG box sequences","serum response factor"],"gene_indices_start":[11,36],"gene_indices_end":[32,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3034,"text":"Carbon catabolite repression of the gnt operon of Bacillus subtilis is mediated by the catabolite control protein CcpA and by HPr , a phosphocarrier protein of the phosphotransferase system .","gene":["phosphotransferase system","gnt operon of Bacillus subtilis","CcpA","HPr"],"gene_indices_start":[36,114,126,164],"gene_indices_end":[67,118,129,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3035,"text":"The frequency of integrations that led to transcription of the lacZ gene was estimated to be 0 . 5% of all integrations , of which 14% were downregulated on differentiation of 32D cells towards neutrophils .","gene":["lacZ gene"],"gene_indices_start":[63],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3036,"text":"Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants .","gene":["Interferon-alpha"],"gene_indices_start":[0],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3037,"text":"ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes .","gene":["yeast MSH2-MSH6","MLH1-PMS1 protein complexes"],"gene_indices_start":[81,101],"gene_indices_end":[96,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3040,"text":"The tumor suppressor and transcriptional factor p53 is a phosphorylated protein .","gene":["p53"],"gene_indices_start":[48],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3041,"text":"Treatment of PCC4 . aza1R cells with an RAR-selective agonist also repressed the expression of EC-1 mRNA while treatment with an RXR-selective agonist reduced EC-1 expression slightly .","gene":["EC-1","EC-1 mRNA"],"gene_indices_start":[95,159],"gene_indices_end":[104,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3042,"text":"By comparing the abundances of many yeast transcripts in isogenic wild-type and paf1 mutant strains , we have identified genes whose expression is affected by PAF1 .","gene":["PAF1","paf1 mutant"],"gene_indices_start":[80,159],"gene_indices_end":[91,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3044,"text":"Most important , infection of the cells with an adenoviral construct expressing this mutant inhibited the induction of VEGF mRNA under conditions that mimic hypoxia .","gene":["VEGF mRNA"],"gene_indices_start":[119],"gene_indices_end":[128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3045,"text":"A constitutive allele of GPA2 could stimulate growth of a strain lacking both RAS genes .","gene":["GPA2","RAS genes"],"gene_indices_start":[25,78],"gene_indices_end":[29,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3047,"text":"We have previously reported that expression of a tumour derived brk cDNA in mouse embryonic fibroblasts and human mammary epithelial cells supports anchorage independent growth , and in the latter potentiates the mitogenic response to epidermal growth factor .","gene":["brk cDNA","epidermal growth factor"],"gene_indices_start":[64,235],"gene_indices_end":[72,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3053,"text":"The serine \/ threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus .","gene":["serine \/ threonine kinase Raf-1","Rats"],"gene_indices_start":[4,60],"gene_indices_end":[35,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3054,"text":"Furthermore , the over-replication phenotype produced by this mutant p65cdc18 is resistant to increased mitotic cyclin \/ CDK activity , a known inhibitor of over-replication .","gene":["cyclin \/ CDK","mutant p65cdc18"],"gene_indices_start":[62,112],"gene_indices_end":[77,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3059,"text":"These data suggest that these sequences located immediately 3' to the breakpoint of the HPFH-3 deletion , exhibit both the structure and the function of an enhancer , and can modify the developmental specificity of the fetal gamma-globin genes , resulting in their continued expression during adult life .","gene":["fetal gamma-globin genes","HPFH-3 deletion"],"gene_indices_start":[88,219],"gene_indices_end":[103,243],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3060,"text":"CONCLUSIONS : While INR correction may be achieved by all the above methods , that relating log reference INR to log local prothrombin time by linear regression analysis is the simplest to perform .","gene":["prothrombin"],"gene_indices_start":[123],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3063,"text":"In this study , we examine the effects of Msx2 expression on OC promoter activation ( luciferase reporter ) by FGF2 \/ FSK and calcitriol in MC3T3-E1 osteoblasts .","gene":["luciferase reporter","FGF2 \/ FSK","Msx2","OC promoter"],"gene_indices_start":[42,61,86,111],"gene_indices_end":[46,72,105,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3064,"text":"Human neuronal Elav-like proteins contain three RNP-type RNA recognition motifs ( RRMs ) .","gene":["Human neuronal Elav-like proteins","RRMs","RNP-type RNA recognition motifs"],"gene_indices_start":[0,48,82],"gene_indices_end":[33,79,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3066,"text":"Interestingly , internal and 5' deletions revealed tha the distal promoter was not required for full transcriptional activity and that the first 631 base pairs of WNT-5A harbored the strongest promoter activity .","gene":["WNT-5A"],"gene_indices_start":[163],"gene_indices_end":[169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3067,"text":"Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit .","gene":["G protein alpha subunit"],"gene_indices_start":[69],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3069,"text":"These studies demonstrate that site-specific recognition of the bxd PRE by d ( GA ) ( n ) repeat binding activities mediates PcG-dependent silencing .","gene":["bxd PRE"],"gene_indices_start":[64],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3071,"text":"Binding affinities of these recombinant phages as determined by the retention of these phages by a His-tag immobilized gp17 column , and by co-immunoprecipitation with purified terminase supported the specific nature of the portal protein and terminase interaction sites .","gene":["portal protein","gp17","terminase interaction sites","terminase"],"gene_indices_start":[119,177,224,243],"gene_indices_end":[123,186,238,270],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3076,"text":"Here , we describe the isolation of MdPin1 , a Pin1 homologue from the plant species apple ( Malus domestica ) and show that it has the same phosphorylation-specific substrate specificity and can be inhibited by juglone in vitro , as is the case for Pin1 .","gene":["Pin1","Pin1","MdPin1"],"gene_indices_start":[36,47,250],"gene_indices_end":[42,51,254],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3079,"text":"( 3 ) This effect occurs without removing TRs from the TRE .","gene":["TRs","TRE"],"gene_indices_start":[42,55],"gene_indices_end":[45,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3080,"text":"A Y . lipolytica Kar2p mutant was isolated that restored interaction with an Sls1p mutant , suggesting that the interaction with Sls1p could be nucleotide and \/ or conformation dependent .","gene":["Sls1p","Sls1p mutant","Y . lipolytica Kar2p mutant"],"gene_indices_start":[2,77,129],"gene_indices_end":[29,89,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3081,"text":"Nine animals served as control animals , whereas 20 animals received a focal arachnoid scar at C1-C2 , which was produced by placement of a kaolin-soaked fibrin sponge on the posterior surface of the spinal cord .","gene":["fibrin"],"gene_indices_start":[154],"gene_indices_end":[160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3082,"text":"High ATP \/ GTP ratios promoted initiation of RNA primer synthesis at 3'-dCTTT sites , whereas low ATP \/ GTP ratios promoted initiation at 3'-dCCC sites .","gene":["3'-dCCC sites","3'-dCTTT sites"],"gene_indices_start":[69,138],"gene_indices_end":[83,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3083,"text":"Two predominant effects were noted : ( i ) the Xaa residue in the dual phosphorylation motif Thr-Xaa-Tyr as well as the length of L12 influence p38 substrate specificity , and ( ii ) the length of L12 plays a major role in controlling autophosphorylation .","gene":["dual phosphorylation motif Thr-Xaa-Tyr","p38"],"gene_indices_start":[66,144],"gene_indices_end":[104,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3084,"text":"This L-myc sequence is amplified 10-20-fold in four SCLC cell line DNAs and in one SCLC tumour specimen taken directly from a patient .","gene":["L-myc sequence"],"gene_indices_start":[5],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3085,"text":"We have previously reported reduced levels of choline acetyltransferase activity in the cerebral cortex of patients who died after a head injury , demonstrating that there is a loss of cortical cholinergic innervation .","gene":["choline acetyltransferase"],"gene_indices_start":[46],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3088,"text":"Six putative MDV genome products , including one Rep and five non-Rep proteins , show high ( 70 . 4-90 . 9% ) amino acid identity to the corresponding six FBNYV proteins , whereas two other Rep proteins encoded by MDV-C2 and C3 are 82 . 3% and 73 . 0% identical to those encoded by SCSV-C2 and C6 , respectively .","gene":["SCSV-C2","FBNYV proteins","C6","C3","Rep proteins","MDV-C2","Rep"],"gene_indices_start":[49,155,190,214,225,282,294],"gene_indices_end":[52,169,202,220,227,289,296],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3090,"text":"While determination of the protein content of the formulae gave no valid information , RAST \/ EAST inhibition was highest for cow's milk , followed by the partially hydrolysed whey formula , partially hydrolysed whey \/ casein formula , soy \/ pork collagen formula , and the amino acid formula .","gene":["soy \/ pork collagen"],"gene_indices_start":[236],"gene_indices_end":[255],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3091,"text":"Transcriptional regulation of SUP35 and SUP45 in Saccharomyces cerevisiae .","gene":["SUP45 in Saccharomyces cerevisiae","SUP35"],"gene_indices_start":[30,40],"gene_indices_end":[35,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3094,"text":"The 2 kb of 5'-flanking region and the 1 . 1 kb of the entire sGTH alpha subunit coding region were sequenced from the genomic clone , sGTH alpha-G1 .","gene":["sGTH alpha-G1","sGTH alpha subunit"],"gene_indices_start":[62,135],"gene_indices_end":[80,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3095,"text":"Here , we describe the isolation of bovine and rat GHF-1 cDNA clones .","gene":["bovine and rat GHF-1 cDNA"],"gene_indices_start":[36],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3096,"text":"These data demonstrate that paxillin localizes to focal adhesions independent of interactions with vinculin and \/ or FAK , and represents the first definitive demonstration of LIM domains functioning as a primary determinant of protein subcellular localization to focal adhesions .","gene":["FAK","vinculin","paxillin","LIM domains"],"gene_indices_start":[28,99,117,176],"gene_indices_end":[36,107,120,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3097,"text":"Systematic functional analysis of V1a \/ V2 hybrid receptors showed that the second intracellular loop of the V1a receptor is required and sufficient for efficient coupling to Gq \/ 11 , whereas the third intracellular loop of the V2 receptor is required and sufficient for coupling to Gs .","gene":["V2 receptor","Gs","Gq \/ 11","V1a \/ V2 hybrid receptors","V1a receptor"],"gene_indices_start":[34,109,175,229,284],"gene_indices_end":[59,121,182,240,286],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3098,"text":"Both NUP98-HOXA9 chimeras transformed NIH 3T3 fibroblasts , and this transformation required the HOXA9 domains for DNA binding and PBX interaction .","gene":["NUP98-HOXA9 chimeras","HOXA9 domains","PBX"],"gene_indices_start":[5,97,131],"gene_indices_end":[25,110,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3099,"text":"KFC , a Ste20-like kinase with mitogenic potential and capability to activate the SAPK \/ JNK pathway .","gene":["KFC","Ste20-like kinase","SAPK \/ JNK pathway"],"gene_indices_start":[0,8,82],"gene_indices_end":[3,25,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3102,"text":"In addition , a potent splicing enhancer sequence isolated in the selection specifically binds a 20-kDa SR protein .","gene":["20-kDa SR protein"],"gene_indices_start":[97],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3104,"text":"Within their polypeptide chain , they all contain those conserved features that define a plant CDPK ; kinase catalytic sequences are linked to a calmodulin-like regulatory domain through a junction region .","gene":["kinase catalytic sequences","CDPK","calmodulin-like regulatory domain"],"gene_indices_start":[95,102,145],"gene_indices_end":[99,128,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3106,"text":"Involvement of AP-2 in regulation of the R-FABP gene in the developing chick retina .","gene":["R-FABP gene","AP-2"],"gene_indices_start":[15,41],"gene_indices_end":[19,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3109,"text":"We have shown previously that in contrast to other extracellular matrix molecules pepsin-solubilized collagen VI ( CVI ) can stimulate DNA synthesis of various mesenchymal cell types , apparently independent of integrin-mediated signal transduction .","gene":["CVI","collagen VI"],"gene_indices_start":[101,115],"gene_indices_end":[112,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3110,"text":"Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes .","gene":["CD2 structure"],"gene_indices_start":[110],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3111,"text":"In the studies reported here , the 5'-flanking region of the human gp130 gene was isolated and the transcription initiation sites were mapped .","gene":["human gp130 gene"],"gene_indices_start":[61],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3112,"text":"Preimmune IgG , anti-GalT Fab fragments , irrelevant polymers and monomeric N-acetylglucosamine had no effect .","gene":["anti-GalT Fab fragments","Preimmune IgG"],"gene_indices_start":[0,16],"gene_indices_end":[13,39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3113,"text":"Cloning and characterization of a cDNA encoding a bacteriophage-type RNA polymerase from the higher plant Chenopodium album .","gene":["bacteriophage-type RNA polymerase"],"gene_indices_start":[50],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3115,"text":"Genomic DNA hybridization suggests that SpSHR2 is a single-copy gene in the S . purpuratus genome .","gene":["SpSHR2"],"gene_indices_start":[40],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3116,"text":"Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA-box of this construct only interacts with a TATA-binding protein ( TBP ) mutant ( TBP-DR2 ) but not with TBP wild-type ( TBPwt ) .","gene":["TBP","U6 gene","pol III","TBP-DR2","TBPwt","TATA-binding protein","TBP wild-type"],"gene_indices_start":[30,71,171,194,209,232,248],"gene_indices_end":[37,78,191,197,216,245,253],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3118,"text":"Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor .","gene":["human glucocorticoid receptor"],"gene_indices_start":[54],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3120,"text":"Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant ( CD44v ) isoforms .","gene":["CD44 variant","CD44v"],"gene_indices_start":[160,175],"gene_indices_end":[172,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3121,"text":"She has since developed a positive anti-cardiolipin antibody but does not meet diagnostic criteria for systemic lupus erythematosis . Conclusion : The presence of known autoimmune disease in a woman with POF should not dissuade the clinician from evaluating for a potential genetic cause .","gene":["anti-cardiolipin antibody"],"gene_indices_start":[35],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3122,"text":"Forced expression of BZAP45 strongly stimulates H4 promoter ( nt -215 to -1 ) \/ CAT reporter gene activity .","gene":["H4 promoter","\/ CAT reporter gene","BZAP45"],"gene_indices_start":[21,48,78],"gene_indices_end":[27,59,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3128,"text":"The equilibrium dissociation binding constant for the interaction of TnrA with the nrgAB promoter fragment was 7 . 7 nM under the conditions used here .","gene":["TnrA","nrgAB promoter fragment"],"gene_indices_start":[69,83],"gene_indices_end":[73,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3129,"text":"Tissue-specific expression of the tmy-1 gene was determined by microinjection of a promoter \/ lacZ fusion gene and with immunohistochemistry by using affinity-purified tissue-specific anti-tropomyosins .","gene":["tmy-1 gene","tissue-specific anti-tropomyosins","promoter \/ lacZ fusion gene"],"gene_indices_start":[34,83,168],"gene_indices_end":[44,110,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3130,"text":"Radiolabeled recombinant TARC specifically bound to T cell lines and peripheral T cells but not to monocytes or granulocytes .","gene":["recombinant TARC"],"gene_indices_start":[13],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3132,"text":"One enigmatic aspect of GATA factor expression is that several GATA proteins , which ostensibly share the same DNA-binding site specificity , are coexpressed in erythroid cells .","gene":["GATA factor","GATA proteins"],"gene_indices_start":[24,63],"gene_indices_end":[35,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3133,"text":"Calcitriol therapy was associated with a decrease in serum iPTH levels ( 701 + \/ - 103 . 9 vs .","gene":["iPTH"],"gene_indices_start":[59],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3135,"text":"Nevertheless , inactivation of the cyclin E-Cdk2 complex in response to mitogen starvation occurs normally in MEFs that have a homozygous deletion of the p27 gene .","gene":["p27 gene","cyclin E-Cdk2 complex"],"gene_indices_start":[35,154],"gene_indices_end":[56,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3136,"text":"Moreover , this enhancement of transcriptional activation by COUP-TFI requires specifically the AF-1 transactivation function of ER and can be observed in the presence of E2 or 4-hydroxytamoxifen but not ICI 164384 .","gene":["ER","COUP-TFI","AF-1"],"gene_indices_start":[61,96,129],"gene_indices_end":[69,100,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3140,"text":"We also demonstrate that the spo20 ( + ) gene product is structurally homologous to Saccharomyces cerevisiae Sec14 , the major phosphatidylinositol transfer protein of budding yeast .","gene":["spo20 ( + ) gene product","Saccharomyces cerevisiae Sec14"],"gene_indices_start":[29,84],"gene_indices_end":[53,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3142,"text":"Although elevated serum levels of antibodies to the nicotinic acetylcholine receptor ( nAChR ) have been reported in neuroleptic treated patients with tardive dyskinesia , such antibodies have not been determined in comparable nondyskinetic patients .","gene":["nAChR","nicotinic acetylcholine receptor"],"gene_indices_start":[52,87],"gene_indices_end":[84,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3144,"text":"Recently , a mutation in the amino-terminus of IB1 was associated with diabetes .","gene":["IB1"],"gene_indices_start":[47],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3145,"text":"In budding yeast , the protein Skp1p , the cullin-family member Cdc53p , and the F-box \/ WD-repeat protein Cdc4p form the SCFCdc4p ubiquitin ligase complex , which targets the cyclin-dependent kinase ( Cdk ) inhibitor Sic1p for proteolysis [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] .","gene":["SCFCdc4p","Cdc53p","ligase complex","Sic1p","Cdc4p","Skp1p","ubiquitin","F-box \/ WD-repeat protein","cyclin-dependent kinase","cullin-family member","Cdk"],"gene_indices_start":[31,43,64,81,107,122,131,141,176,202,218],"gene_indices_end":[36,63,70,106,112,130,140,155,199,205,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3146,"text":"We show that p73 can transcriptionally inhibit a number of cellular and viral promoters .","gene":["p73"],"gene_indices_start":[13],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3147,"text":"Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway .","gene":["Raf-MEK-extracellular signal-regulated kinase pathway","Rnd3"],"gene_indices_start":[22,98],"gene_indices_end":[26,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3154,"text":"Convulsive seizure during a treatment with interferon alpha for chronic viral hepatitis C .","gene":["interferon alpha"],"gene_indices_start":[43],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3155,"text":"The ratio of the activity of arogenate dehydrogenase to that of prephenate dehydrogenase ( approximately 3 : 1 ) remained constant throughout purification , and the two activities were therefore inseparable .","gene":["prephenate dehydrogenase","arogenate dehydrogenase"],"gene_indices_start":[29,64],"gene_indices_end":[52,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3157,"text":"At the end of the experiment the urinary porphyrin excretion and the porphyrin content in lijver and skin were diminished in HCB-CQ-treated animals by about 50% compared to the HCB controls .","gene":["porphyrin","porphyrin"],"gene_indices_start":[41,69],"gene_indices_end":[50,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3158,"text":"YAC and cosmid contigs spanning the Batten disease ( CLN3 ) region at 16p12 . 1-p11 . 2 .","gene":["Batten disease ( CLN3 ) region"],"gene_indices_start":[36],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3159,"text":"Hu-Met-1 mRNA expression in a small number of human T cell tumor lines did not correlate with any particular phenotype or stage of development .","gene":["Hu-Met-1 mRNA"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3160,"text":"Identification of dynein heavy chain genes expressed in human and mouse testis : chromosomal localization of an axonemal dynein gene .","gene":["dynein heavy chain genes","axonemal dynein gene"],"gene_indices_start":[18,112],"gene_indices_end":[42,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3165,"text":"At physiological doses , either insulin-like growth factor I ( IGF-I ) or insulin turned out to be as potent as dibutyryl cAMP ( dbcAMP ) in increasing UCP1 gene transcription rate ( 1 h ) and also UCP1 mRNA accumulation ( 3 h ) , their maximal effect ( 15-fold increase ) reached upon treatment for 24 h .","gene":["IGF-I","UCP1 mRNA","UCP1 gene","insulin","insulin-like growth factor I"],"gene_indices_start":[32,63,74,152,198],"gene_indices_end":[60,68,81,161,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3167,"text":"Therefore , the positive cAMP control of the hypoxic SRP1 and HEM13 genes was uncoupled from the HOG pathway .","gene":["SRP1","HEM13 genes"],"gene_indices_start":[53,62],"gene_indices_end":[57,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3169,"text":"The hybridizing clone of V . vulnificus chromosomal DNA complemented a V . cholerae fur mutant .","gene":["V . cholerae fur mutant"],"gene_indices_start":[71],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3170,"text":"Furthermore , RING1 overexpression results in enhanced expression of the proto-oncogenes c-jun and c-fos .","gene":["c-jun","c-fos","RING1"],"gene_indices_start":[14,89,99],"gene_indices_end":[19,94,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3178,"text":"The cloned HindIII fragment , which was shown by DNA sequence analysis to encode the N-terminal half of the B . subtilis IF2 protein and 0 . 2 kb of upstream flanking sequence , was utilized as a homologous probe to clone an overlapping 2 . 76-kb ClaI chromosomal fragment containing the entire IF2 structural gene .","gene":["B . subtilis IF2 protein","entire IF2 structural gene","HindIII fragment","2 . 76-kb ClaI chromosomal fragment"],"gene_indices_start":[11,108,237,288],"gene_indices_end":[27,132,272,314],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3179,"text":"The 5'flanking region is highly GC rich , with multiple CpG doublets , and contains multiple binding sites for Sp1 .","gene":["Sp1"],"gene_indices_start":[111],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3181,"text":"The gene product of cotS was confirmed to be identical to Cot40-2 by SDS-PAGE and immunoblotting from Escherichia coli transformed with a plasmid containing the cotS region .","gene":["Cot40-2","cotS","cotS region"],"gene_indices_start":[20,58,161],"gene_indices_end":[24,65,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3184,"text":"Presentation of a horse cytochrome c peptide by multiple H-2b class I major histocompatibility complex ( MHC ) molecules to C57BL \/ 6- and bm1-derived cytotoxic T lymphocytes : presence of a single MHC anchor residue may confer efficient peptide-specific CTL recognition .","gene":["horse cytochrome c peptide","H-2b class I major histocompatibility complex","MHC","MHC anchor residue"],"gene_indices_start":[18,57,105,198],"gene_indices_end":[44,102,108,216],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3185,"text":"The major myosin-binding domain of skeletal muscle MyBP-C ( C protein ) resides in the COOH-terminal , immunoglobulin C2 motif .","gene":["immunoglobulin","C protein","C2 motif","myosin-binding domain","skeletal muscle MyBP-C"],"gene_indices_start":[10,35,60,103,118],"gene_indices_end":[31,57,69,117,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3186,"text":"The differences in the CPIgG , CRP , and fibrinogen levels in patients who were diagnosed with ACS versus those who were not ( non-ACS ) were evaluated .","gene":["fibrinogen","CPIgG","CRP"],"gene_indices_start":[23,31,41],"gene_indices_end":[28,34,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3187,"text":"FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages , similar to SF-1 in steroidogenic tissues .","gene":["SF-1","FTF"],"gene_indices_start":[0,128],"gene_indices_end":[3,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3188,"text":"The 2 cDNAs differed in the length of their respective 3' untranslated regions , of 577 bp in Cp . F6 and 72 bp in Cp . F10 , in both of which a putative polyadenylation signal was identified .","gene":["Cp . F10","Cp . F6"],"gene_indices_start":[94,115],"gene_indices_end":[101,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3194,"text":"To overcome this problem , we have overexpressed Kex2p using the baculovirus \/ insect cell expression system .","gene":["Kex2p"],"gene_indices_start":[49],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3195,"text":"Basal promoter activity is enhanced by a functional M1 domain in LHR-expressing mouse Leydig tumor cells ( MLTC ) but not in non-expressing CHO cells .","gene":["M1 domain"],"gene_indices_start":[52],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3202,"text":"Recently , a human transcription elongation factor P-TEFb , consisting of CDK9 kinase , cyclin T and other associated factors , has been shown to interact with Tat to restore Tat activation in HeLa nuclear extract depleted of P-TEFb .","gene":["human transcription elongation factor P-TEFb","P-TEFb","cyclin T","Tat","Tat","CDK9 kinase"],"gene_indices_start":[13,74,88,160,175,226],"gene_indices_end":[57,85,96,163,178,232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3203,"text":"Following the injection of PGF2 alpha , heifers were observed visually for signs of estrus at 0730 and 1630 ( 45 min each ) .","gene":["PGF2 alpha"],"gene_indices_start":[27],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3204,"text":"ECP and tryptase levels in serum were measured before and after the last oral challenge .","gene":["tryptase","ECP"],"gene_indices_start":[0,8],"gene_indices_end":[3,16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3207,"text":"Mean+ \/ -SD serum VEGF concentrations were significantly higher ( P < 0 . 001 ) in women with PCO and PCOS ( 3 . 4+ \/ -0 . 7 and 3 . 2+ \/ -0 . 66 ng \/ ml respectively ) compared with women with normal ovaries ( 2 . 3+ \/ -0 . 5 ng \/ ml ) .","gene":["serum VEGF"],"gene_indices_start":[12],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3215,"text":"nos-1 and nos-2 , two genes related to Drosophila nanos , regulate primordial germ cell development and survival in Caenorhabditis elegans .","gene":["nos-2","Drosophila nanos","nos-1"],"gene_indices_start":[0,10,39],"gene_indices_end":[5,15,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3216,"text":"The addition of an equimolar complex of the fourth and seventh largest subunits , purified from pol II holoenzyme by ion-exchange chromatography in the presence of urea , restored promoter-directed initiation activity to pol II delta 4 \/ 7 .","gene":["pol II delta 4 \/ 7","pol II holoenzyme"],"gene_indices_start":[96,221],"gene_indices_end":[113,239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3217,"text":"We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c-sis \/ PDGF-B proto-oncogene in various pathologic settings where constitutive expression of this gene has been observed .","gene":["c-sis \/ PDGF-B proto-oncogene"],"gene_indices_start":[98],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3218,"text":"We found that the 3'-end-adjacent sequence CA ( N ) 3-10AGTNNAA , conserved in plant Pol II-specific U snRNA genes , is essential for the 3'-end formation of U2 transcripts and , similar to the vertebrate 3' box , is highly tolerant to mutation .","gene":["U2 transcripts","Pol II-specific U snRNA genes"],"gene_indices_start":[85,158],"gene_indices_end":[114,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3220,"text":"In addition , the gcd1-101 mutation suppressed the low translational efficiency of GCN4-lacZ mRNA observed in gcn2- and gcn3- cells .","gene":["gcd1-101 mutation","gcn2-","gcn3-","GCN4-lacZ mRNA"],"gene_indices_start":[18,83,110,120],"gene_indices_end":[35,97,115,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3221,"text":"In this report , we describe the characterization of two early class II flagellar genes contained in the orfX-fliP locus .","gene":["orfX-fliP locus","class II flagellar genes"],"gene_indices_start":[63,105],"gene_indices_end":[87,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3222,"text":"The effect of the fatty acid cyclo-oxygenase inhibitor indomethacin on cerebral blood flow ( CBF ) and the metabolic rate for oxygen ( CMRO2 ) was studied in paralyzed and artificially ventilated rats .","gene":["fatty acid cyclo-oxygenase"],"gene_indices_start":[18],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3226,"text":"The expressed G1-G2 bound to both hyaluronan and link protein indicating that the immunoglobulin-fold motif and proteoglycan tandem repeat loops of the G1 domain were correctly folded .","gene":["immunoglobulin-fold motif","link protein","G1-G2","G1 domain"],"gene_indices_start":[14,49,82,152],"gene_indices_end":[19,61,107,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3227,"text":"Among genes induced by added pMesogenin1 is Xwnt-8 , a signaling factor that induces a similar repertoire of marker genes and a similar cellular phenotype .","gene":["Xwnt-8","pMesogenin1"],"gene_indices_start":[29,44],"gene_indices_end":[40,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3228,"text":"A phylogenetic tree of members of the T2 \/ S-RNase superfamily in plants was obtained .","gene":["T2 \/ S-RNase superfamily"],"gene_indices_start":[38],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3229,"text":"Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene .","gene":["human 85 kDa cytosolic phospholipase A2 gene"],"gene_indices_start":[41],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3230,"text":"Gtx mRNA accumulates in parallel with the RNAs encoding the major structural proteins of myelin , myelin basic protein ( MBP ) , and proteolipid protein ( PLP ) during postnatal brain development ; Gtx mRNA decreases in parallel with MBP and PLP mRNAs in the brains of myelin-deficient rats , which have a point mutation in the PLP gene .","gene":["MBP","Gtx mRNA","PLP","PLP mRNAs","MBP","myelin basic protein","Gtx mRNA","proteolipid protein","PLP gene"],"gene_indices_start":[0,98,121,133,155,198,234,242,328],"gene_indices_end":[8,118,124,152,158,206,237,251,336],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3231,"text":"Two separate NF1-binding loci were also found in the equivalent IE68 gene of HCMV ( Towne ) DNA , but in this case the DNA sequence and competition filter binding experiments indicated a maximum of only four to five consensus binding sites encompassing the promoter-enhancer region .","gene":["IE68 gene","NF1-binding loci"],"gene_indices_start":[13,64],"gene_indices_end":[29,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3232,"text":"The second patient had received pituitary-derived growth hormone for treatment of growth hormone deficiency , secondary to a third ventricle teratoma , exised 13 yr earlier .","gene":["pituitary-derived growth hormone","growth hormone"],"gene_indices_start":[32,82],"gene_indices_end":[64,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3234,"text":"The hypertension with elevated PRA , however , was resistant to the angiotensin II ( AII ) analog [ Sar1 , Ile8 ] ALL .","gene":["angiotensin II","AII"],"gene_indices_start":[68,85],"gene_indices_end":[82,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3236,"text":"The Escherichia coli tet-repressor ( TetR ) operator system was used to develop a variation of the yeast two-hybrid assay in which disruptions of protein-protein interactions can be identified by a positive selection .","gene":["TetR","Escherichia coli tet-repressor"],"gene_indices_start":[4,37],"gene_indices_end":[34,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3237,"text":"Western blotting ( immunoblotting ) with an antiserum to a partial SOD expressed in Escherichia coli revealed two proteins with estimated molecular masses of 19 and 29 kDa .","gene":["SOD"],"gene_indices_start":[67],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3241,"text":"Unlike wild-type p53 , the delta proAE mutant cDNA can be stably expressed in tumor derived cell lines with few immediate detrimental effects .","gene":["wild-type p53","delta proAE mutant cDNA"],"gene_indices_start":[7,27],"gene_indices_end":[20,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3242,"text":"The complete exon-intron structure of the 156-kb human gene NFKB1 , which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma : implications for NF-kappa B-mediated signal transduction .","gene":["p50 proteins","NF-kappa B","156-kb human gene NFKB1","p105","I kappa B-gamma"],"gene_indices_start":[42,86,95,133,148],"gene_indices_end":[65,90,107,143,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3245,"text":"To test promotor function , chimeric genes were constructed linking fragments of chicken IGF-I 5'-flanking DNA to a promoterless reporter plasmid .","gene":["IGF-I"],"gene_indices_start":[89],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3246,"text":"Here , we identify Rsc3 and Rsc30 as novel components of the essential yeast remodeler RSC complex .","gene":["Rsc3","yeast remodeler RSC complex","Rsc30"],"gene_indices_start":[19,28,71],"gene_indices_end":[23,33,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3249,"text":"Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions .","gene":["Ig heavy chain intronic enhancer core region","endogenous Ig heavy chain locus"],"gene_indices_start":[39,90],"gene_indices_end":[70,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3251,"text":"To confirm the GapIII protein activity , constructs containing different GapIII-GRD domains were transformed into iral mutant yeast to determine their relative ability to replace IRA1 functionally .","gene":["GapIII-GRD domains","IRA1","GapIII protein"],"gene_indices_start":[15,73,179],"gene_indices_end":[29,91,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3254,"text":"Growth factor stimulation rapidly induces a reversible change in the electrophoretic mobility of the ternary complex , accompanied by increased phosphorylation of the Elk-1 C-terminal region and by the activation of a 42 kd cellular Elk-1 kinase .","gene":["Growth factor","42 kd cellular Elk-1 kinase","Elk-1 C-terminal region"],"gene_indices_start":[0,167,218],"gene_indices_end":[13,190,245],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3255,"text":"Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea .","gene":["malonyl-coenzyme A decarboxylase gene","eryM"],"gene_indices_start":[54,92],"gene_indices_end":[91,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3256,"text":"This experimental design was used to determine the effect of displacement of the alpha 4-2 binding site on the repression of alpha 4 gene transcription by ICP4 .","gene":["alpha 4 gene","ICP4","alpha 4-2 binding site"],"gene_indices_start":[81,125,155],"gene_indices_end":[103,137,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3258,"text":"We have screened the elastin gene for mutations responsible for supravalvular aortic stenosis ( SVAS ) in two large , independently collected families with isolated ( nonsyndromic ) SVAS .","gene":["elastin gene"],"gene_indices_start":[21],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3260,"text":"Southern blotting and single strand conformation polymorphism analyses did not show tumor-specific alterations of this gene in gliomas and RT-PCR studies showed expression in glioma cell lines , suggesting that ANOVA is not the chromosome 19q glioma tumor suppressor gene .","gene":["ANOVA"],"gene_indices_start":[211],"gene_indices_end":[216],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3261,"text":"The backbone dynamics of residues located in the folded part of CRP2 ( LIM2 ) R122A have been characterized by proton-detected ( 15 ) N NMR spectroscopy .","gene":["CRP2","LIM2","R122A"],"gene_indices_start":[64,71,78],"gene_indices_end":[68,75,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3264,"text":"Collectively , these results show that the differential utilization of Staf zinc finger 1 represents a new , critical determinant of the transcriptional activation mechanism for the Xenopus tRNA ( Sec ) and human U6 snRNA genes .","gene":["Xenopus tRNA ( Sec )","human U6 snRNA genes","Staf zinc finger 1"],"gene_indices_start":[71,182,207],"gene_indices_end":[89,202,227],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3265,"text":"The corresponding gene was identified in the GenBankTM data base by sequence alignment and termed RPS30A .","gene":["RPS30A"],"gene_indices_start":[98],"gene_indices_end":[104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3266,"text":"Southern blot analysis of endonuclease-digested genomic DNA from primary chick embryo fibroblasts ( CEF ) suggested that MEK2 is a single-copy gene in this vertebrate species .","gene":["MEK2"],"gene_indices_start":[121],"gene_indices_end":[125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3267,"text":"The members of the Myb family of transcription factors are defined by homology in the DNA-binding domain ; all bind the Myb-binding site ( MBS ) sequence ( YG ( A \/ G ) C ( A \/ C \/ G ) GTT ( G \/ A ) ) .","gene":["Myb family of transcription factors","MBS","YG ( A \/ G ) C ( A \/ C \/ G ) GTT ( G \/ A ) )","Myb-binding site"],"gene_indices_start":[19,120,139,156],"gene_indices_end":[54,136,142,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3268,"text":"The predominant binding activity was not Ets-1 but rather two independent DNA-protein complexes that comigrated in mobility shift assays .","gene":["Ets-1"],"gene_indices_start":[41],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3269,"text":"( i ) Complete Grb10 expression from cDNA with an ecdysone-regulated transient expression system stimulated PDGF-BB- , IGF-I , and insulin- but not epidermal growth factor ( EGF ) -induced DNA synthesis in an ecdysone dose-responsive fashion .","gene":["epidermal growth factor","EGF","IGF-I","Grb10"],"gene_indices_start":[15,119,148,174],"gene_indices_end":[20,124,171,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3271,"text":"High plasma AVP levels observed in the two cases suggest that SSRIs stimulate AVP secretion , thereby causing SIADH .","gene":["AVP","plasma AVP"],"gene_indices_start":[5,78],"gene_indices_end":[15,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3272,"text":"These data indicate a functional role for U1 in NRS-mediated splicing inhibition .","gene":["U1"],"gene_indices_start":[42],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3273,"text":"Based on subcellular fractionation , the 47-kDa P-CIP2 protein is mostly cytosolic .","gene":["47-kDa P-CIP2 protein"],"gene_indices_start":[41],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3274,"text":"Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts .","gene":["c-myc"],"gene_indices_start":[8],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3275,"text":"Binding of cell type-specific nuclear proteins to the 5'-flanking region of maize C4 phosphoenolpyruvate carboxylase gene confers its differential transcription in mesophyll cells .","gene":["maize C4 phosphoenolpyruvate carboxylase gene"],"gene_indices_start":[76],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3277,"text":"The identity between hnRNPs H and H' is 96% , between H and F 78% , and between H' and F 75% , respectively .","gene":["F","hnRNPs H","F","H'","H","H'"],"gene_indices_start":[21,34,54,60,80,87],"gene_indices_end":[29,36,55,61,82,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3278,"text":"Jkappa DNA-binding sites were not required for this activation , and a mutant EBNA-3C protein unable to bind Jkappa activated transcription as efficiently as wild-type EBNA-3C , indicating that EBNA-3C can regulate transcription through a mechanism that is independent of Jkappa .","gene":["EBNA-3C","Jkappa","Jkappa DNA-binding sites","Jkappa","wild-type EBNA-3C","mutant EBNA-3C protein"],"gene_indices_start":[0,71,109,158,194,272],"gene_indices_end":[24,93,115,175,201,278],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3279,"text":"As pH and Hb can also affect mixed venous CO2 content , the effect on Q was also assessed .","gene":["Hb"],"gene_indices_start":[10],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3280,"text":"Upon UV damage , Crb2 is transiently modified , probably phosphorylated , with a similar timing of phosphorylation in Chk1 kinase , which is reported to restrain Cdc2 activation .","gene":["Cdc2","Chk1 kinase","Crb2"],"gene_indices_start":[17,118,162],"gene_indices_end":[21,129,166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3282,"text":"Furthermore , ICER negatively autoregulates the alternative promoter , thus generating a feedback loop .","gene":["ICER"],"gene_indices_start":[14],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3283,"text":"Consistent with this similarity , the cdc28-P8 mutant accumulates unspliced precursors at the restrictive temperature .","gene":["cdc28-P8 mutant"],"gene_indices_start":[38],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3284,"text":"Cotransfection of Ets-2 and p44 mitogen-activated protein ( MAP ) kinase expression vectors strongly potentiated HB-EGF promoter activation in response to deltaRaf-1 : ER .","gene":["mitogen-activated protein ( MAP ) kinase","deltaRaf-1 : ER","HB-EGF promoter","p44","Ets-2"],"gene_indices_start":[18,28,32,113,155],"gene_indices_end":[23,31,72,128,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3287,"text":"Creatine kinase release after hepatic artery embolization in patients with carcinoid tumors .","gene":["Creatine kinase"],"gene_indices_start":[0],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3289,"text":"SRE activity is dependent upon the activation by phosphorylation of a ternary complex factor ; included among the ternary complex factors is Elk-1 .","gene":["Elk-1"],"gene_indices_start":[141],"gene_indices_end":[146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3291,"text":"The p73pct1 \/ p85cdc10 complex binds both in vitro and in vivo to MCB but not SCB or E2F sites .","gene":["E2F sites","p73pct1 \/ p85cdc10 complex","SCB","MCB"],"gene_indices_start":[4,66,78,85],"gene_indices_end":[30,69,81,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3292,"text":"Transient expression of VSF-1 in protoplasts stimulated vs-1 dependent activation of the -76 \/ grp1 . 8 minimal promoter .","gene":["vs-1","-76 \/ grp1 . 8 minimal promoter","VSF-1"],"gene_indices_start":[24,56,89],"gene_indices_end":[29,60,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3295,"text":"The c-myc \/ TGF-alpha HCCs were also characterized by a particularly strong expression of TGF-alpha and very low apoptotic index in contrast to high levels of apoptosis in peritumorous tissues and c-myc HCCs .","gene":["c-myc","TGF-alpha","c-myc \/ TGF-alpha"],"gene_indices_start":[4,90,197],"gene_indices_end":[21,99,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3296,"text":"The primary structure of each of the three proteins has about 70% homology with that of mouse contrapsin , in contrast to 43-46% homology with that of rat alpha 1-protease inhibitor .","gene":["rat alpha 1-protease","mouse contrapsin"],"gene_indices_start":[88,151],"gene_indices_end":[104,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3299,"text":"Treatment of N18TG-2 cells with a demethylating agent , 5-aza-deoxycytidine , resulted in an expression of mlt 1 , indicating that the repression of mlt 1 is attributable to methylation Thus , mlt 1 is a novel target gene that is silenced by methylation during liver tumorigenesis initiated by SV40 T antigen .","gene":["mlt 1","mlt 1","SV40 T antigen","mlt 1"],"gene_indices_start":[107,149,193,294],"gene_indices_end":[112,154,198,308],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3302,"text":"A 13 base-pair oligonucleotide spanning nucleotides +80 to +92 of the 5 S RNA gene retained specific and high-affinity binding , although the latter was reduced sixfold relative to longer DNA fragments .","gene":["5 S RNA gene"],"gene_indices_start":[70],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3306,"text":"Two promoters were identified by S1 nuclease mapping : P1 , which lies about 72 bp upstream from the structural gene ; and P2 , which lies about 35 bp upstream .","gene":["S1 nuclease"],"gene_indices_start":[33],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3309,"text":"The MSY2 associated kinase is not casein kinase 2 , the kinase believed to phosphorylate mRNP3+4 in oocytes , but a yet unidentified kinase .","gene":["mRNP3+4","casein kinase 2","kinase","MSY2","kinase","kinase"],"gene_indices_start":[4,20,34,56,89,133],"gene_indices_end":[8,26,49,62,96,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3310,"text":"( 1997 ) Nature 387 , 370-376 ) ] , we suggest that the metal fluoride ions replaced phosphate at the two ATP-binding sites of the iron protein , Kp2 .","gene":["Kp2"],"gene_indices_start":[146],"gene_indices_end":[149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3311,"text":"Only one gene , fibronectin ( FN ) , was highly overexpressed ( > 60-fold ) in LNCaP-r cells , consistent with previously reported overexpression of FN in prostate cancer .","gene":["FN","FN","fibronectin"],"gene_indices_start":[16,30,149],"gene_indices_end":[27,32,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3313,"text":"Rat kidney carboxylesterase .","gene":["Rat kidney carboxylesterase"],"gene_indices_start":[0],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3314,"text":"This suggests roles for both the CE1 and CE2 elements in regulating Hoxb1 gene expression during development .","gene":["CE2","CE1","Hoxb1 gene"],"gene_indices_start":[33,41,68],"gene_indices_end":[36,44,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3315,"text":"The human insulin-like growth factor II ( IGF-II ) gene contains four promoters ( P1 , P2 , P3 and P4 ) .","gene":["IGF-II","human insulin-like growth factor II"],"gene_indices_start":[4,42],"gene_indices_end":[39,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3317,"text":"The cis-acting element , identified as CACGTGACCCG , is located 34 bp upstream from the transcription initiation site , and contains the core sequence of the upstream promoter sequence of Ad2MLP .","gene":["CACGTGACCCG"],"gene_indices_start":[39],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3319,"text":"This interaction is mediated by the SH2 domain of Crk and can be inhibited with a phosphopeptide containing the Crk-SH2 binding motif .","gene":["SH2 domain","Crk-SH2 binding motif","Crk"],"gene_indices_start":[36,50,112],"gene_indices_end":[46,53,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3321,"text":"Luteinizing hormone-releasing hormone analog therapy of uterine fibroid : analysis of results obtained with buserelin administered intranasally and goserelin administered subcutaneously as a monthly depot .","gene":["Luteinizing hormone-releasing hormone"],"gene_indices_start":[0],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3322,"text":"Proteins known to bind the PEPCK CRE include the CRE-binding protein ( CREB ) and members of the CCAAT \/ enhancer-binding protein ( C \/ EBP ) family .","gene":["CRE-binding protein","PEPCK","C \/ EBP","CCAAT \/ enhancer-binding protein","CREB","CRE"],"gene_indices_start":[27,33,49,71,97,132],"gene_indices_end":[32,36,68,75,129,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3324,"text":"Other hemostatic values evaluated were activated partial thromboplastin times , prothrombin times , thrombin times , fibrinogen , platelet counts , and fibrin \/ fibrinogen degradation products .","gene":["thrombin","prothrombin","fibrin \/ fibrinogen","fibrinogen","thromboplastin"],"gene_indices_start":[57,80,100,117,152],"gene_indices_end":[71,91,108,127,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3325,"text":"The human gene fragment ligated to the minimal rat liver glucokinase promoter was shown to work as an enhancer in the hepatocyte transfection system .","gene":["glucokinase"],"gene_indices_start":[57],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3329,"text":"A chimeric VP16-Tat construct containing the leucine mutations showed no increased AP-1 responsiveness in comparison with that of the VP16 activation domain alone .","gene":["VP16 activation domain","chimeric VP16-Tat construct","AP-1"],"gene_indices_start":[2,83,134],"gene_indices_end":[29,87,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3330,"text":"An examination of the role of the carboxyl terminus in regulating NGFI-B transcriptional activity revealed that , in accordance with other nuclear receptors , mutants lacking portions of the carboxyl terminus had greatly decreased activity .","gene":["NGFI-B"],"gene_indices_start":[66],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3334,"text":"Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides .","gene":["mitogen-activated protein kinase","thrombospondin-1","Beta 1 integrin-","thrombospondin-1 peptides"],"gene_indices_start":[0,87,133,154],"gene_indices_end":[16,119,149,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3335,"text":"In addition , an mck1 mds1 mrk1 triple disruptant was viable .","gene":["mck1","mds1","mrk1"],"gene_indices_start":[17,22,27],"gene_indices_end":[21,26,31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3337,"text":"One defective RNA with a large deletion in the p70 coding region was able to replicate efficiently , both when inoculated with the helper genome and when inoculated with a second complementing defective RNA that supplied a wild-type p70 .","gene":["wild-type p70","p70 coding region"],"gene_indices_start":[47,223],"gene_indices_end":[64,236],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3338,"text":"In contrast , H-NS negative regulation operated only in the absence of Fur .","gene":["H-NS","Fur"],"gene_indices_start":[14,71],"gene_indices_end":[18,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3339,"text":"Although the molecular mechanisms involved in this regulation are currently being elucidated , very little is known about the trans-acting factors that allow expression of the nitrate and nitrite reductase genes which code for the first enzymes in the pathway .","gene":["nitrate and nitrite reductase genes"],"gene_indices_start":[176],"gene_indices_end":[211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3341,"text":"In this article , the clinical actions of the principal dopamine receptor stimulating agents ( apomorphine and its derivatives ; piribedil , rye-ergot derivatives ) are discussed on the basis of their biochemical and pharmacological properties .","gene":["dopamine receptor"],"gene_indices_start":[56],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3342,"text":"To address these questions , a recombinant FRAP \/ mTOR protein and a FRAP \/ mTOR immunoprecipitate were utilized in in vitro kinase assays to phosphorylate 4E-BP1 .","gene":["4E-BP1","kinase","FRAP \/ mTOR","recombinant FRAP \/ mTOR protein"],"gene_indices_start":[31,69,125,156],"gene_indices_end":[62,80,131,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3343,"text":"Here we report the cloning , expression , and biochemical characterization of the 32-kDa subunit of human ( h ) TFIID , termed hTAFII32 .","gene":["TFIID","hTAFII32"],"gene_indices_start":[112,127],"gene_indices_end":[117,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3344,"text":"The Scm and ph proteins share a homology domain with 38% identity over a length of 65 amino acids , termed the SPM domain , that is located at their respective C termini .","gene":["SPM domain","ph","Scm"],"gene_indices_start":[4,12,111],"gene_indices_end":[7,14,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3345,"text":"Clb \/ Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7 .","gene":["replication initiator proteins Mcm2-7","Clb \/ Cdc28 kinases"],"gene_indices_start":[0,50],"gene_indices_end":[19,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3346,"text":"This repression was reversed agonists of either receptor demonstrating a functional interaction between NCoR and PPARalpha . RXRalpha heterodimeric complexes in mammalian cells .","gene":["PPARalpha . RXRalpha heterodimeric complexes","NCoR"],"gene_indices_start":[104,113],"gene_indices_end":[108,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3348,"text":"Thus , the association of PS1 fragments may be maintained during cycles of phosphorylation \/ dephosphorylation of the PS1 CTF .","gene":["PS1 CTF","PS1 fragments"],"gene_indices_start":[26,118],"gene_indices_end":[39,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3350,"text":"Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm .","gene":["casein kinase I isoforms"],"gene_indices_start":[5],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3354,"text":"Based on this analysis , we propose that the interactions of Sos with the switch 1 and switch 2 regions of Ras have distinct functional consequences : the interaction with switch 2 mediates the anchoring of Ras to Sos , whereas the interaction with switch 1 leads to disruption of the nucleotide-binding site and GDP dissociation .","gene":["Sos","Sos","Ras","Ras"],"gene_indices_start":[61,107,207,214],"gene_indices_end":[64,110,210,217],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3355,"text":"Peroxisome proliferator-activated receptors ( PPARs ) and retinoid X receptors ( RXRs ) are nuclear hormone receptors that are activated by fatty acids and 9-cis-retinoic acid , respectively .","gene":["RXRs","Peroxisome proliferator-activated receptors","retinoid X receptors","PPARs"],"gene_indices_start":[0,46,58,81],"gene_indices_end":[43,51,78,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3358,"text":"However , D8 binding was observed by nuclease protection with lactotroph- as well as somatotroph-like cell nuclear protein .","gene":["nuclease","somatotroph-like cell nuclear protein","D8"],"gene_indices_start":[10,37,85],"gene_indices_end":[12,45,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3360,"text":"The significance of the phenolphthalein sulphatase test for the differentiation and identification of Nocardia species .","gene":["phenolphthalein sulphatase"],"gene_indices_start":[24],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3361,"text":"These results indicate that T . C . , LDL-C . , HDL-C . , HDL2-C . , apo B , apo A-I \/ B ratio and apo A-II \/ B ratio are predictive risk factors of the coronary heart disease .","gene":["HDL-C","apo B","HDL2-C","LDL-C","apo A-I \/ B","apo A-II \/ B"],"gene_indices_start":[38,48,58,69,77,99],"gene_indices_end":[43,53,64,74,88,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3363,"text":"To identify cis-acting elements that target c-myc mRNA for downregulation during myogenesis , we stably transfected C2C12 cells with mutant myc genes or chimeric genes in which various myc sequences were fused to the human beta-globin gene or to the bacterial chloramphenicol acetyltransferase ( CAT ) gene .","gene":["mutant myc genes","CAT","c-myc mRNA","myc sequences","bacterial chloramphenicol acetyltransferase","human beta-globin gene"],"gene_indices_start":[44,133,185,217,250,296],"gene_indices_end":[54,149,198,239,293,299],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3364,"text":"We report here that in cultured Jurkat T cells , Cbl is coprecipitated with antibody against the adapter protein Grb2 .","gene":["Cbl","adapter protein Grb2"],"gene_indices_start":[49,97],"gene_indices_end":[52,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3365,"text":"These findings and the differential tissue distribution of p54 suggest that this novel SR protein may participate in regulation of alternative splicing in a tissue- and substrate-dependent manner .","gene":["p54","SR protein"],"gene_indices_start":[59,87],"gene_indices_end":[62,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3367,"text":"Mutational studies revealed that it was the homeodomain binding site II sequence that was required for this regulation .","gene":["homeodomain binding site II sequence"],"gene_indices_start":[44],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3370,"text":"Additionally , MIP-2A antagonizes cell growth regulatory role of MBP-1 .","gene":["MBP-1","MIP-2A"],"gene_indices_start":[15,65],"gene_indices_end":[21,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3371,"text":"We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene .","gene":["human PDE5A gene"],"gene_indices_start":[115],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3373,"text":"In the point mutant we observed normal repair of endonuclease III site ( i . e . as wild type ) , but no removal of CPDs at the MAT alpha and HML alpha loci .","gene":["HML alpha loci","MAT alpha","endonuclease III site"],"gene_indices_start":[49,128,142],"gene_indices_end":[70,137,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3374,"text":"The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1 , which has been implicated in capping viral RNAs .","gene":["homolog of alphavirus nonstructural protein nsP1","1a"],"gene_indices_start":[27,43],"gene_indices_end":[29,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3375,"text":"Two putative Rev proteins with apparent molecular masses of 18 and 16 kDa were expressed by p2 \/ 2 and p176 , while p20 expressed only a 16-kDa species .","gene":["Rev proteins"],"gene_indices_start":[13],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3376,"text":"These analyses re-open the question whether all the CesA genes encode cellulose synthases or whether some of the sub-class members may encode other non-cellulosic ( 1-- > 4 ) beta-glycan synthases in plants .","gene":["CesA genes","cellulose synthases","non-cellulosic ( 1-- > 4 ) beta-glycan synthases"],"gene_indices_start":[52,70,148],"gene_indices_end":[62,89,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3380,"text":"To assess the ability of the atria to maintain elevated plasma concentrations of atrial natriuretic peptide ( ANP ) , the temporal changes in plasma ANP concentrations were studied in seven chloralose-anaesthetized dogs during 4 h of sustained rapid cardiac pacing .","gene":["plasma ANP","ANP","atrial natriuretic peptide"],"gene_indices_start":[81,110,142],"gene_indices_end":[107,113,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3381,"text":"Our results show that the temperature-sensitive rad54-3 allele blocks mitotic recombination between tandemly repeated DYZ3 satellite sequences and significantly stabilizes a human DYZ5 satellite-containing YAC clone .","gene":["DYZ3 satellite sequences","temperature-sensitive rad54-3 allele","human DYZ5"],"gene_indices_start":[26,118,174],"gene_indices_end":[62,142,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3382,"text":"Again residue Glu-381 of beta was notably reduced and no missing residue from the epsilon peptide could be identified , but the peptide sequence limited the possible choices to Ser-106 , Ser-107 , or Ser-108 .","gene":["epsilon peptide"],"gene_indices_start":[82],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3384,"text":"Nucleotide sequences between the env gene and the LTR of SFV-1 were determined .","gene":["env gene"],"gene_indices_start":[33],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3391,"text":"The aspirate from a parathyroid cyst was watery clear and contained high amount of parathyroid hormone .","gene":["parathyroid hormone"],"gene_indices_start":[83],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3393,"text":"Our results indicate that Shh can drive continued cycling in immature , proliferating CGNPs .","gene":["Shh"],"gene_indices_start":[26],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3395,"text":"Urease activity , judged as the amount of ammonia production from urea , could be measured at 25 ng per tube ( S \/ N = 1 . 5 ) with Jack bean meal urease .","gene":["Urease","Jack bean meal urease"],"gene_indices_start":[0,132],"gene_indices_end":[6,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3397,"text":"Using reference probes as internal standards , we show that the ost transcription unit is located within the cytogenetic band interval 89A1 , 2 on the right arm of the third chromosome , and that it exerts diagnostic segmentation gene expression patterns in the embryo .","gene":["ost transcription unit"],"gene_indices_start":[64],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3398,"text":"The proteasome is a large complex consisting of two multisubunit structures , the 20S and 19S ( PA700 ) or P28 complexes , that combine to form the 26S particles .","gene":["26S particles","19S ( PA700 )","20S","P28 complexes"],"gene_indices_start":[82,90,107,148],"gene_indices_end":[85,103,120,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3399,"text":"The amino acid sequences of the predicted RfbA and RfbB homologs showed identities of 75 . 7% ( 87 . 9% total similarity ) and 78 . 0% ( 86 . 5% total similarity ) , respectively .","gene":["RfbA","RfbB homologs"],"gene_indices_start":[42,51],"gene_indices_end":[46,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3400,"text":"The UBA domains of RAD23 and DDI1 are required for these interactions .","gene":["DDI1","RAD23","UBA domains"],"gene_indices_start":[4,19,29],"gene_indices_end":[15,24,33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3403,"text":"The results strengthen the conclusion that predominantly dynamic activity increases the G4 content of mature innervated fast muscles .","gene":["G4"],"gene_indices_start":[88],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3405,"text":"Serum ferritin concentration and bone marrow iron stores .","gene":["ferritin"],"gene_indices_start":[6],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3406,"text":"The mechanism of ligand-activated estrogen receptor alpha ( ERalpha ) -dependent activation of gene expression through the SRE was determined by mutational analysis of the promoter , analysis of mitogen-activated protein kinase ( MAPK ) pathway activation by E2 , and transforming growth factor alpha ( TGF-alpha ) as a positive control .","gene":["E2","mitogen-activated protein kinase","SRE","estrogen receptor alpha","transforming growth factor alpha","TGF-alpha","ERalpha","MAPK"],"gene_indices_start":[34,60,123,195,230,259,268,303],"gene_indices_end":[57,67,126,227,234,261,300,312],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3408,"text":"The large subfamily of receptor tyrosine kinases ( RTKs ) for which EPH is the prototype have likely roles in intercellular communication during normal mammalian development , but the biochemical signalling pathways utilised by this family are poorly characterised .","gene":["EPH","receptor tyrosine kinases","RTKs"],"gene_indices_start":[23,51,68],"gene_indices_end":[48,55,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3409,"text":"Analysis of RAR alpha mutants in transfection studies reveals that the DNA binding domain is sufficient for inhibition of BZLF1 activity .","gene":["RAR alpha mutants","BZLF1"],"gene_indices_start":[12,122],"gene_indices_end":[29,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3411,"text":"Comparison of the proportion of nonsynonymous ( pN ) and synonymous ( pS ) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions ( CDR1 and CDR2 ) .","gene":["CDR2","CDR1","MHC contact regions","tamarin variable region genes"],"gene_indices_start":[115,234,256,265],"gene_indices_end":[144,253,260,269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3414,"text":"The COOH-terminal region of the transcripts contained fifteen triplet repeats ( GCT ; alanine ) at nucleotide 465 to 509 , which is significantly expanded compared to the rat RL14 .","gene":["rat RL14"],"gene_indices_start":[171],"gene_indices_end":[179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3416,"text":"Gene constructs consisting of human growth hormone ( hGH ) gene driven by promoter \/ regulatory sequence of mouse metallothionein ( mMT ) , viral thymidine kinase ( vTK ) , rat cholecystokinin ( rCCK ) , or chicken beta-actin ( cBA ) gene were injected into the cytoplasm of fertilized medaka eggs via the micropyle .","gene":["mouse metallothionein","mMT","hGH","viral thymidine kinase","cBA","rCCK","rat cholecystokinin","chicken beta-actin","human growth hormone","vTK"],"gene_indices_start":[30,53,108,132,140,165,173,195,207,228],"gene_indices_end":[50,56,129,135,162,168,192,199,225,231],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3417,"text":"DNase I footprinting analysis indicated that DREF binds to the 24-bp DRE region of the DNA polymerase alpha gene in which 8-bp palindromic sequences are centered .","gene":["DREF","DNA polymerase alpha gene","DRE","DNase I"],"gene_indices_start":[0,45,69,87],"gene_indices_end":[7,49,72,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3418,"text":"This study was carried out to analyze PRL secretion in metastatic prostate cancer patients both at basal conditions and in response to L-Dopa and metoclopramide , which represents the most classical inhibitory and stimulatory tests for PRL secretion , respectively .","gene":["PRL","PRL"],"gene_indices_start":[38,236],"gene_indices_end":[41,239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3419,"text":"Expression of PTPRO was also observed in human CD34+ bone marrow cells and 5-FU-treated murine primitive stem cells .","gene":["human CD34+","PTPRO"],"gene_indices_start":[14,41],"gene_indices_end":[19,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3422,"text":"Additional exonuclease III protection was observed beyond the core region on both the 5' and 3' sides , suggesting that E1 interacted with more distal sequences as well .","gene":["exonuclease III","E1"],"gene_indices_start":[11,120],"gene_indices_end":[26,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3427,"text":"However , during our work with a replication-deficient virus expressing the ASF \/ SF2 splicing factor from a progesterone antagonist-inducible gene cassette , we discovered that ASF \/ SF2 was expressed at a significant level in the 293 producer cell line , even in the absence of inducer .","gene":["ASF","SF2","ASF","SF2","SF2 splicing"],"gene_indices_start":[76,82,178,184],"gene_indices_end":[79,85,94,181,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3428,"text":"Molecular cloning of mouse glycolate oxidase .","gene":["mouse glycolate oxidase"],"gene_indices_start":[21],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3431,"text":"Using the rap1t alleles to generate wild-type cells differing only in telomere tract lengths , we also show that telomere position effects are highly sensitive to changes in the size ( or structure ) of the telomeric tract .","gene":["rap1t alleles"],"gene_indices_start":[10],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3432,"text":"Two protease-resistant fragments spanning the N- and C-terminal halves of the nuclease were identified using different proteases which cleave the protein in the same region .","gene":["proteases","nuclease"],"gene_indices_start":[78,119],"gene_indices_end":[86,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3433,"text":"Dorsal root ganglia neuron-specific promoter activity of the rabbit beta-galactoside alpha1 , 2-fucosyltransferase gene .","gene":["rabbit beta-galactoside alpha1 , 2-fucosyltransferase gene"],"gene_indices_start":[61],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3434,"text":"Peroxisome proliferator-activated receptors ( PPAR ) modulate transcription by binding to specific peroxisome proliferator-response elements ( PPRE ) through heterodimerization with the 9-cis retinoic acid receptor ( RXR ) .","gene":["PPAR","Peroxisome proliferator-activated receptors","peroxisome proliferator-response elements","PPRE","9-cis retinoic acid receptor","RXR"],"gene_indices_start":[0,46,99,143,186,217],"gene_indices_end":[43,50,140,147,214,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3437,"text":"Mechanistically , the presence of the GRR appears to stop further degradation of p50 and to stabilize the molecule .","gene":["p50"],"gene_indices_start":[81],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3439,"text":"Therefore , in order to search for the latent genes , we used allotype-specific oligonucleotides for b5 , b6 and b9 to probe DNAs from both normal and T . brucei-infected rabbits by Southern blotting .","gene":["b6","b9","b5"],"gene_indices_start":[101,106,113],"gene_indices_end":[103,108,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3440,"text":"A high-frequency restriction fragment length polymorphism was evident in the DNA from 29 unrelated individuals using the enzyme BglII .","gene":["BglII"],"gene_indices_start":[128],"gene_indices_end":[133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3441,"text":"RPA190 encodes a polypeptide chain of 186 , 270 daltons in a large uninterrupted reading frame .","gene":["RPA190"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3442,"text":"The arginyl peptide bonds that are cleaved in the conversion of human factor IX to factor IXa by factor XIa were identified as Arg145-Ala146 and Arg180-Val181 .","gene":["factor IXa","human factor IX","factor XIa"],"gene_indices_start":[64,83,97],"gene_indices_end":[79,93,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3443,"text":"Synthetic oligonucleotides representing the 19 bp repeat unit strongly reduced the activity of the IE1 \/ 2 enhancer \/ promoter in cotransfection assays after transient expression .","gene":["IE1 \/ 2 enhancer \/ promoter"],"gene_indices_start":[99],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3447,"text":"This motif has been shown to mediate protein interactions in the case of ankyrin as well as several other repeat-bearing proteins .","gene":["ankyrin"],"gene_indices_start":[73],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3457,"text":"This repression does not require the PU . 1 transactivation or PEST domains and cannot be reversed by p300 expression .","gene":["PU . 1","PEST domains","p300"],"gene_indices_start":[37,63,102],"gene_indices_end":[43,75,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3458,"text":"Possible roles of RAD5 putative ATPase \/ DNA helicase activity in DNA repair and in the maintenance of wild-type rates of instability of simple repetitive sequences are discussed .","gene":["ATPase \/ DNA helicase","RAD5"],"gene_indices_start":[18,32],"gene_indices_end":[22,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3460,"text":"CDC31 is required for SPB duplication and encodes a calmodulin-like protein that is most closely related to caltractin \/ centrin , a protein associated with the Chlamydomonas basal body .","gene":["CDC31","calmodulin-like protein"],"gene_indices_start":[0,52],"gene_indices_end":[5,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3465,"text":"A bovine abomasum lambda gt11 cDNA library was screened with a monoclonal antibody raised against the rabbit H , K-ATPase beta subunit .","gene":["rabbit H , K-ATPase beta subunit"],"gene_indices_start":[102],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3467,"text":"After MOPP therapy , complete remission of Hodgkin's disease was accompanied by normalization of the glucocerebrosidase level and disappearance of Gaucher's cells .","gene":["glucocerebrosidase"],"gene_indices_start":[101],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3468,"text":"67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project .","gene":["cdc18","cdc14"],"gene_indices_start":[52,62],"gene_indices_end":[57,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3469,"text":"Optical CD , and spectral and activity analyses were used to examine reactivity of HO isozymes with NO species produced by NO donors .","gene":["HO isozymes"],"gene_indices_start":[83],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3470,"text":"Neither gene possesses a distinct transcriptional start site as shown by nuclease S1 analysis .","gene":["nuclease S1"],"gene_indices_start":[73],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3472,"text":"Deletion analyses of the construct revealed that the transcription of BOXF1 gene is regulated by BOX DNA , preferentially in undifferentiated EC cells versus differentiated cells .","gene":["BOXF1 gene","BOX DNA"],"gene_indices_start":[70,97],"gene_indices_end":[80,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3475,"text":"Ig-alpha and Ig-beta contain extended cytoplasmic structure ( 61 and 48 amino acids , respectively ) and associate with cytoplasmic effectors indicating that they are directly involved in signal transduction .","gene":["Ig-alpha","Ig-beta"],"gene_indices_start":[0,13],"gene_indices_end":[8,20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3477,"text":"Examination of the sequence of the Punta Toro M gene product reveals the presence of multiple hydrophobic sequences including a 19-amino acid , carboxy-proximal , hydrophobic region ( G2 ) .","gene":["Punta Toro M gene product","19-amino acid , carboxy-proximal , hydrophobic region ( G2 )"],"gene_indices_start":[35,128],"gene_indices_end":[60,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3478,"text":"In angiodysplasia , ectatic vessels in the mucosa appeared to contain less collagen type IV than similarly sized vessels in the submucosa , and perforating vessels appeared in many cases to lose staining at the level of the muscularis mucosae .","gene":["collagen type IV"],"gene_indices_start":[75],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3479,"text":"RESULTS : Total IgE levels showed a tendency to diminish .","gene":["IgE"],"gene_indices_start":[16],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3481,"text":"The sequence of the putative RBP1 protein contains two copies of an RNA recognition motif , two glutamine stretches , an asparagine-rich region , a methionine-rich region , and two long potential alpha-helixes .","gene":["RBP1 protein"],"gene_indices_start":[29],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3482,"text":"In a group of 13 patients with obliterative arteriopathies of the lower limbs the plasma levels of thrombomodulin ( TM ) , betathromboglobulin ( beta-TG ) , D-dimer ( DD ) and plasminogen activator-inhibitor ( pAI-1 ) were measured , and compared to the values obtained from 10 healthy volunteers .","gene":["TM","thrombomodulin","betathromboglobulin","pAI-1","beta-TG","DD","D-dimer","plasminogen activator-inhibitor"],"gene_indices_start":[99,116,123,145,157,167,176,210],"gene_indices_end":[113,118,142,152,164,169,207,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3483,"text":"Research was carried out on the rheumatoid factors in the serum of 917 patients by means of two tests ( one using polystyrene and one with erythrocytes ) and the results obtained were compared using a method of reference .","gene":["rheumatoid factors"],"gene_indices_start":[32],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3485,"text":"However , alterations in electrostatic and hydrophobic interactions created by the three amino acid substitutions prevent the conformational change in the enzyme usually produced by calmodulin binding .","gene":["calmodulin"],"gene_indices_start":[182],"gene_indices_end":[192],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3486,"text":"The products of the Saccharomyces cerevisiae CIN1 , CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function .","gene":["Saccharomyces cerevisiae CIN1","CIN2","CIN4 genes"],"gene_indices_start":[20,52,61],"gene_indices_end":[49,56,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3488,"text":"Transcription initiation sites of the rat II beta- , III beta , and O beta-globin genes were determined to be 52 base pairs ( bp ) 5'-upstream of the translation initiation codon ( ATG ) , in each gene by primer extension analysis .","gene":["rat II beta- , III beta , and O beta-globin genes"],"gene_indices_start":[38],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3491,"text":"Here we present evidence that the distal half ( Stem 2 ) of the conserved base-paired stem structure found in all hY RNAs also plays a critical role in the export process .","gene":["hY RNAs"],"gene_indices_start":[114],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3494,"text":"S1 nuclease analysis of RNA from chemically induced B95-8 cells and from Vero cells cotransfected with NotI repeat promoter-CAT and Z showed that Z transactivation increased the level of correctly initiated , stable RNA transcripts .","gene":["Z","S1 nuclease","Z","NotI repeat promoter-CAT"],"gene_indices_start":[0,103,132,146],"gene_indices_end":[11,127,133,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3495,"text":"The nifJ and nifH promoters of Klebsiella pneumoniae are divergently transcribed sigma 54-dependent promoters that are positively activated by the NifA protein .","gene":["NifA protein","sigma 54-dependent promoters","nifH promoters of Klebsiella pneumoniae","nifJ"],"gene_indices_start":[4,13,81,147],"gene_indices_end":[8,52,109,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3496,"text":"Both toxins in a dose 10-fold surpassimg the maximum permissible concentration increased activity of glutathione peroxidase in brain tissue ; moreover , toluene increased chemiluminescence intensity , which attested to activation of free radical processes .","gene":["glutathione peroxidase"],"gene_indices_start":[101],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3497,"text":"To this end , we analyzed the phosphorylation status of a universal tyrosine kinase substrate , the transforming Shc adapter protein , in fibroblasts expressing the viral oncogene .","gene":["tyrosine kinase","Shc adapter protein"],"gene_indices_start":[68,113],"gene_indices_end":[83,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3498,"text":"Partial characterization of the active site human platelet cAMP phosphodiesterase , PDE3A , by site-directed mutagenesis .","gene":["PDE3A","human platelet cAMP phosphodiesterase"],"gene_indices_start":[44,84],"gene_indices_end":[81,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3499,"text":"The region between DXS52 and Factor VIII gene in the human Xq28 chromosomal band contains a G+C-rich isochore to which many genes have been mapped .","gene":["Factor VIII gene","DXS52"],"gene_indices_start":[19,29],"gene_indices_end":[24,45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3500,"text":"Biochemical characterization of valosin-containing protein , a protein tyrosine kinase substrate in hematopoietic cells .","gene":["valosin-containing protein","protein tyrosine kinase"],"gene_indices_start":[32,63],"gene_indices_end":[58,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3502,"text":"We also provide evidence that gar2 is phosphorylated in vitro by a p13 ( suc1 ) -Sepharose-bound kinase from Schizosaccharomyces pombe extracts that displays cell cycle-regulated activity similar to that of the p34 ( cdc2 ( kinase .","gene":["gar2","kinase","p34","cdc2","p13","suc1"],"gene_indices_start":[30,67,73,97,211,217],"gene_indices_end":[34,70,77,103,214,221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3503,"text":"Our results support a model where both E2F- and CDE-mediated repression , acting at different stages in the cell cycle , are dependent on promoter-specific CHR elements .","gene":["CHR elements"],"gene_indices_start":[156],"gene_indices_end":[168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3504,"text":"Indeed , significant level of CAT activity was observed in human lung adenocarcinoma ( A549-1 ) cells which had been incubated with a complex of T7 RNA polymerase , pT7-EMC-CAT DNA and DC-chol cationic liposomes .","gene":["pT7-EMC-CAT DNA","CAT","T7 RNA polymerase"],"gene_indices_start":[30,145,165],"gene_indices_end":[33,162,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3507,"text":"The difference of hardness over time of composite specimens was measured using Knoop hardness measurements taken at the top and bottom surfaces of resin specimens made in a Teflon mold the same dimensions as the cavity prepared in dentin .","gene":["dentin"],"gene_indices_start":[231],"gene_indices_end":[237],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3508,"text":"An alternatively spliced MAdCAM-1 variant was identified that lacks exon 4 encoding the mucin domain , and may mediate leukocyte adhesion to LPAM-1 without adhesion to the alternate receptor , L-selectin .","gene":["LPAM-1","mucin","MAdCAM-1","L-selectin"],"gene_indices_start":[25,88,141,193],"gene_indices_end":[33,93,147,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3510,"text":"EM analysis demonstrated that only one Rep-DNA complex was formed on ch-19 target DNA .","gene":["Rep-DNA complex"],"gene_indices_start":[39],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3513,"text":"We previously demonstrated that acute expression of the bovine papillomavirus type 1 ( BPV1 ) E2 protein in HeLa and HT-3 cervical carcinoma cell lines greatly reduced cellular proliferation by imposing a specific G1 \/ S phase growth arrest .","gene":["E2 protein"],"gene_indices_start":[94],"gene_indices_end":[104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3515,"text":"In insulin-responsive cells , Akt phosphorylates and inactivates the serine \/ threonine kinase glycogen synthase kinase-3 ( GSK-3 ) .","gene":["serine \/ threonine kinase","Akt","glycogen synthase kinase-3","GSK-3"],"gene_indices_start":[30,69,95,124],"gene_indices_end":[33,94,121,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3516,"text":"Cyclin D1-associated kinase activity and protein levels were increased in mammary tumors from murine mammary tumor virus-pp60 ( c-src527F ) transgenic mice .","gene":["murine mammary tumor virus-pp60 ( c-src527F )","Cyclin D1-associated kinase"],"gene_indices_start":[0,94],"gene_indices_end":[27,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3519,"text":"Mutation analysis demonstrates that the motif TCCCCT is critical for PyRo1 interaction .","gene":["TCCCCT","PyRo1"],"gene_indices_start":[46,69],"gene_indices_end":[52,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3520,"text":"Cdc2 co-precipitates with Pch1 in S . pombe cell lysates , although Cdc2 may not be the major catalytic partner of a Pch1 kinase in vivo .","gene":["Pch1","Cdc2","Cdc2","Pch1 kinase"],"gene_indices_start":[0,26,68,117],"gene_indices_end":[4,30,72,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3527,"text":"The IgG subclass profile of untreated coeliac disease was found to be the same as in healthy controls ( IgG1 approximately IgG2 > IgG3 > IgG4 ) , with only the magnitude of the individual subclass responses being increased in coeliac patients .","gene":["IgG3","IgG2","IgG","IgG1","IgG4"],"gene_indices_start":[4,104,123,130,137],"gene_indices_end":[7,108,127,134,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3529,"text":"Sequence analysis of this region revealed three eight-bp repetitive elements , the deletion of which restored wild-type levels of luciferase activity to the -916-bp reporter plasmid .","gene":["luciferase"],"gene_indices_start":[130],"gene_indices_end":[140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3531,"text":"Here , we describe directional chromosome walking studies starting from D8S260 as well as D8S285 .","gene":["D8S285","D8S260"],"gene_indices_start":[72,90],"gene_indices_end":[78,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3532,"text":"RUSH-1 beta is a 95-kDa truncated version of RUSH-1 alpha that results from alternative splicing of a 57-bp exon as confirmed by genomic cloning .","gene":["RUSH-1 alpha","RUSH-1 beta"],"gene_indices_start":[0,45],"gene_indices_end":[11,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3533,"text":"Reduction in dosage restored normal taste sense in all three , but in two the drug had to be discontinued because of persisting high transaminase levels .","gene":["transaminase"],"gene_indices_start":[133],"gene_indices_end":[145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3535,"text":"Thus , our studies suggest that pV-mediated activation of HIV-1 LTR activity is controlled by the nuclear translocation of the NF-kappaB transcription factor , which is mediated by IkappaBalpha serine phosphorylation and degradation , but also by a still undefined NF-kappaB-independent pathway .","gene":["IkappaBalpha","NF-kappaB transcription factor","HIV-1 LTR"],"gene_indices_start":[58,127,181],"gene_indices_end":[67,157,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3538,"text":"Analysis of one cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggests a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain .","gene":["GPR2","EZH1","EZH1 protein"],"gene_indices_start":[66,98,156],"gene_indices_end":[70,102,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3539,"text":"We analysed two regions involved in preS2 \/ S gene transcription of the HBV adw subtype : the diverged TATA box and a putative initiator element .","gene":["preS2","S gene"],"gene_indices_start":[36,44],"gene_indices_end":[41,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3547,"text":"When introduced into recJ+ strains , srjA mutations conferred hyperrecombinational and hyper-UVr phenotypes .","gene":["recJ+","srjA"],"gene_indices_start":[21,37],"gene_indices_end":[26,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3550,"text":"The influence of Epstein-Barr virus seropositivity on the efficacy of intravenous immune globulin in children with immune thrombocytopenic purpura .","gene":["immune globulin"],"gene_indices_start":[82],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3552,"text":"Plasma renin activity did not change in response to head-up tilt or isoprenaline infusion in the patients .","gene":["renin"],"gene_indices_start":[7],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3553,"text":"On the role of transferrin in the uptake of gallium by tumor cells .","gene":["transferrin"],"gene_indices_start":[15],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3558,"text":"Interestingly , the IR5 ORF of EHV-1 possesses a sequence of 13 amino acids ( CAYWCCLGHAFAC ) that is a perfect match to the consensus zinc finger motif ( C-X2-4-C-X2-15-C \/ H-X2-4-C \/ H ) .","gene":["IR5 ORF","C-X2-4-C-X2-15-C \/ H-X2-4-C \/ H","CAYWCCLGHAFAC"],"gene_indices_start":[20,78,155],"gene_indices_end":[27,91,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3559,"text":"Mutating a potential cleavage site located N-terminal to the protease domain , Gln2526-Asp2527 , diminished processing .","gene":["protease domain , Gln2526-Asp2527"],"gene_indices_start":[61],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3561,"text":"An RME1-independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation .","gene":["IME1 transcript"],"gene_indices_start":[93],"gene_indices_end":[108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3563,"text":"The effect of osmotic flow on the distribution of horseradish peroxidase within the intercellular spaces of toad bladder epithelium .","gene":["horseradish peroxidase"],"gene_indices_start":[50],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3567,"text":"Here we show that a novel isoform of Rapl GTPase-activating protein , called rap1GAPII , binds specifically to the alpha-subunits of the G ( i ) family of heterotrimeric G-proteins .","gene":["G ( i ) family","Rapl GTPase-activating protein","rap1GAPII","heterotrimeric G-proteins"],"gene_indices_start":[37,77,137,155],"gene_indices_end":[67,86,151,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3569,"text":"Transient transfection assays using reporter gene constructs containing various lengths of the 5' mdr1b sequences revealed that the sequence located between-247 to -126 bp was important for the expression of the reporter gene in many different cell lines .","gene":["5' mdr1b sequences"],"gene_indices_start":[95],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3570,"text":"It is concluded that opiate receptors bordering the fourth cerebral ventricle mediate the cardiovascular and hypnotic action of fentanyl .","gene":["opiate receptors"],"gene_indices_start":[21],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3571,"text":"A number of serological tests measuring the presence of Helicobacter pylori-specific serum immunoglobulin G ( IgG ) are now commercially available .","gene":["IgG","immunoglobulin G"],"gene_indices_start":[91,110],"gene_indices_end":[107,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3574,"text":"RT-PCR and in situ hybridization analyses of a time course of juvenile testis development indicate that Spo11 expression begins in early meiotic Prophase I , prior to the pachytene stage , with increasing accumulation of mRNA through the pachytene stage .","gene":["Spo11"],"gene_indices_start":[104],"gene_indices_end":[109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3575,"text":"However , the beta5L splice variant was found only in the retina .","gene":["beta5L splice variant"],"gene_indices_start":[14],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3576,"text":"The P-wr and P-rr cDNA sequences are very similar in their 5' regions .","gene":["P-wr","P-rr cDNA sequences"],"gene_indices_start":[4,13],"gene_indices_end":[8,32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3577,"text":"By site-specific mutagenesis , we also show that individual ICP27 C-terminal amino acid residues that are positionally conserved in ICP27 homologs in other herpesviruses ( D-357 , E-358 , H-479 , C-400 , C-483 , and C-488 ) are critical for trans-regulatory activity .","gene":["ICP27 C-terminal amino acid residues","ICP27 homologs"],"gene_indices_start":[60,132],"gene_indices_end":[96,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3579,"text":"Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12-myristate 13-acetate , while that of other elements did not .","gene":["P element","SV40 promoter"],"gene_indices_start":[26,50],"gene_indices_end":[35,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3580,"text":"The pWP-19 also encodes the AAV inverted terminal repeats for integration and replication and the herpes virus thymidine kinase promoter-driven gene for neomycin resistance ( neoR ) .","gene":["pWP-19","neoR","thymidine kinase"],"gene_indices_start":[4,111,175],"gene_indices_end":[10,127,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3581,"text":"Binding site selection using in vitro-synthesized proteins reveals that the ROR alpha 1 and ROR alpha 2 isoforms bind DNA as monomers to hormone response elements composed of a 6-bp AT-rich sequence preceding a half-site core motif PuGGTCA ( RORE ) .","gene":["ROR alpha 1","hormone response elements","ROR alpha 2 isoforms","RORE","core motif PuGGTCA"],"gene_indices_start":[76,92,137,221,242],"gene_indices_end":[87,112,162,239,246],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3583,"text":"Our findings also provide the basis for the development of assays to screen for the ligands to testis receptor 2 and hERR1 .","gene":["hERR1","testis receptor 2"],"gene_indices_start":[95,117],"gene_indices_end":[112,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3585,"text":"Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase \/ stress-activated protein kinase pathway .","gene":["Cdc42","small GTP-binding proteins Rac1","c-Jun N-terminal kinase \/ stress-activated protein kinase"],"gene_indices_start":[19,55,68],"gene_indices_end":[50,60,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3587,"text":"UV cross-linking experiments show that TEP has an apparent molecular mass of approximately 65 kDa .","gene":["TEP"],"gene_indices_start":[39],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3588,"text":"Elevated expression of a previously uncharacterized gene , SPP381 , efficiently suppresses the growth and splicing defects of a temperature-sensitive ( Ts ) mutant prp38-1 .","gene":["SPP381","mutant prp38-1"],"gene_indices_start":[59,157],"gene_indices_end":[65,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3590,"text":"Expression of activated Cdc42 results in the translocation of PKClambda from the nucleus into the cytosol , and Cdc42 and PKClambda colocalize at the plasma membrane and in the cytoplasm .","gene":["PKClambda","PKClambda","Cdc42","Cdc42"],"gene_indices_start":[24,62,112,122],"gene_indices_end":[29,71,117,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3591,"text":"NPT II synthesis , measured by agar plate assays of kanamycin resistance and by immunoprecipitation of the NPT II protein , was repressed in the presence of cysteine and derepressed in its absence .","gene":["NPT II protein","NPT II"],"gene_indices_start":[0,107],"gene_indices_end":[6,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3592,"text":"Also like the thrombin receptor , PAR2 can be activated by the hexapeptide corresponding to its tethered ligand sequence independent of receptor cleavage .","gene":["thrombin receptor","PAR2"],"gene_indices_start":[14,34],"gene_indices_end":[31,38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3593,"text":"The 5' region of ADH5 contains consensus binding sites for the transcriptional regulatory proteins , Sp1 , AP2 , LF-A1 , NF-1 , NF-A2 , and NF-E1 .","gene":["NF-1","NF-A2","LF-A1","NF-E1","Sp1","ADH5","AP2"],"gene_indices_start":[17,101,107,113,121,128,140],"gene_indices_end":[21,104,110,118,125,133,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3594,"text":"Tumor necrosis factor signaling to stress-activated protein kinase ( SAPK ) \/ Jun NH2-terminal kinase ( JNK ) and p38 .","gene":["stress-activated protein kinase","p38","\/ Jun NH2-terminal kinase","JNK","Tumor necrosis factor","SAPK"],"gene_indices_start":[0,35,69,76,104,114],"gene_indices_end":[21,66,73,101,107,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3595,"text":"The class II Escherichia coli alanine tRNA synthetase aminoacylates RNA miniduplexes , which reconstruct the acceptor end of alanine tRNA with the critical G3 : U70 base pair .","gene":["alanine tRNA","class II Escherichia coli alanine tRNA synthetase aminoacylates RNA miniduplexes"],"gene_indices_start":[4,125],"gene_indices_end":[84,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3597,"text":"Elevation of intracellular Ca ( 2+ ) levels are also involved because treatment with receptor-associated protein , nifedipine , MK801 , removal of Ca ( 2+ ) from the medium and dantrolene all served to inhibit calcium elevation and attenuate the activation of CREB .","gene":["CREB"],"gene_indices_start":[260],"gene_indices_end":[264],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3598,"text":"Ten days of cefadroxil therapy was used to treat 44 children with urinary tract infection and CRP values greater than or equal to 28 microgram \/ ml ( CRP-positive group ) .","gene":["CRP"],"gene_indices_start":[94],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3601,"text":"The amino acid sequence alignment of TC II with that of other Cbl binding proteins ( rat intrinsic factor , human transcobalamin I and porcine haptocorrin ) revealed only 33% overall homology .","gene":["porcine haptocorrin","rat intrinsic factor","TC II","human transcobalamin I","Cbl binding proteins"],"gene_indices_start":[37,62,85,108,135],"gene_indices_end":[42,82,105,130,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3605,"text":"Me ( 2 ) SO-induced neuronal differentiation of N1E-115 neuroblastoma cells increased both the expression of the endogenous Ntr-1 gene and reporter genes driven by NTR-1 promoter sequences by 3-4-fold .","gene":["NTR-1 promoter sequences","endogenous Ntr-1 gene"],"gene_indices_start":[113,164],"gene_indices_end":[134,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3607,"text":"The E6 \/ E7 promoter of all genital human papillomaviruses is responsible for expression of the viral transforming genes .","gene":["viral transforming genes","E6 \/ E7 promoter"],"gene_indices_start":[4,96],"gene_indices_end":[20,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3608,"text":"The effect of calcitonin , a large amount of calcium given orally , pentagastrin and glucagon on plasma 47Ca radioactivity curves in subjects pretreated with 47Ca was examined .","gene":["calcitonin"],"gene_indices_start":[14],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3611,"text":"As the rate of protein synthesis decreases during late embryogenesis , levels of SEC-1 and its cognate mRNA decline precipitously .","gene":["SEC-1"],"gene_indices_start":[81],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3613,"text":"No TATA or Inr sequence was found .","gene":["Inr sequence"],"gene_indices_start":[11],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3616,"text":"The evolution of the CCR5 cis-regulatory region versus the open reading frame as well as among different domains of the open reading frame differed from one another .","gene":["CCR5 cis-regulatory region"],"gene_indices_start":[21],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3618,"text":"Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor .","gene":["mannose 6-phosphate receptor"],"gene_indices_start":[50],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3620,"text":"The results strongly support the notion that the OBF1-binding sites and the OBF1 protein are important for normal ARS function as an origin of replication .","gene":["OBF1 protein","ARS","OBF1-binding sites"],"gene_indices_start":[49,76,114],"gene_indices_end":[67,88,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3622,"text":"The GHR mRNA : GHBP mRNA ratio was 1 . 1 + \/ - 0 . 12 and remained unchanged during differentiation .","gene":["GHBP mRNA","GHR mRNA"],"gene_indices_start":[4,15],"gene_indices_end":[12,24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3624,"text":"The tissue specificity of gene expression was identical to that described previously for the CaMV 35S domain B enhancer element .","gene":["CaMV 35S domain B enhancer element"],"gene_indices_start":[93],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3625,"text":"Substitution of the Ser-Thr sites with the phosphomimetic Asp generated a constitutively active form of IRF-3 that functioned as a very strong activator of promoters containing PRDI-PRDIII or ISRE regulatory elements .","gene":["IRF-3","ISRE regulatory elements","PRDI-PRDIII"],"gene_indices_start":[104,177,192],"gene_indices_end":[109,188,216],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3627,"text":"Precipitation using GST fusion proteins containing Fyn SH2 , SH3 , and SH2 \/ SH3 domains revealed that PI 3-kinase bound principally to the SH3 domain of Fyn .","gene":["Fyn","PI 3-kinase","SH3 domain","GST fusion proteins","SH3","Fyn","SH2 \/ SH3 domains","SH2"],"gene_indices_start":[20,51,55,61,71,103,140,154],"gene_indices_end":[39,54,58,64,88,114,150,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3628,"text":"Five of the Aeromonas strains and one of V cholerae non-O1 were positive for enterotoxin activity .","gene":["enterotoxin"],"gene_indices_start":[77],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3629,"text":"Northern blot analysis of total cellular RNA indicated that xylP encodes a 1 . 3-kb transcript which is induced by xylan .","gene":["xylP"],"gene_indices_start":[60],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3631,"text":"A second domain , located in the C-terminal 437 amino acids of IE1 , is required for inhibitory and DNA-binding activities .","gene":["IE1"],"gene_indices_start":[63],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3635,"text":"Despite abundant expression of NtmybAS transcripts in mature pollen , gPAL1 transcripts were not detectable in pollen .","gene":["gPAL1 transcripts","NtmybAS transcripts"],"gene_indices_start":[31,70],"gene_indices_end":[50,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3636,"text":"Moreover , Lck was reversibly co-immunoprecipitated with p95Vav , and the stoichiometry of binding increased in anti-CD3-treated Jurkat cells .","gene":["Lck","p95Vav"],"gene_indices_start":[11,57],"gene_indices_end":[14,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3638,"text":"For this purpose , we used a series of plasmid constructs encoding different forms of the envelope glycoprotein E of the flavivirus tick-borne encephalitis virus .","gene":["envelope glycoprotein E of the flavivirus tick-borne encephalitis virus"],"gene_indices_start":[90],"gene_indices_end":[161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3639,"text":"We constructed a yeast reporter strain containing the lacZ gene under the control of the CYC1 promoter associated with three copies of TRE-1 .","gene":["CYC1 promoter","TRE-1","lacZ gene"],"gene_indices_start":[54,89,135],"gene_indices_end":[63,102,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3643,"text":"Although it has two potential binding sites , the purified MerR homodimer binds only one Hg ( II ) ion , employing Cys82 from one monomer and Cys117 and Cys126 from the other .","gene":["MerR homodimer"],"gene_indices_start":[59],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3644,"text":"The envelope glycoproteins of Rous sarcoma virus ( RSV ) , gp85 and gp37 , are anchored in the membrane by a 27-amino acid , hydrophobic domain that lies adjacent to a 22-amino acid , cytoplasmic domain at the carboxy terminus of gp37 .","gene":["envelope glycoproteins of Rous sarcoma virus ( RSV )","gp37","gp37","gp85"],"gene_indices_start":[4,59,68,230],"gene_indices_end":[56,63,72,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3645,"text":"HupI showed strong identity to rubredoxin and rubredoxin-like proteins from many other bacteria .","gene":["rubredoxin","HupI","rubredoxin-like proteins"],"gene_indices_start":[0,31,46],"gene_indices_end":[4,41,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3646,"text":"The already elevated prolactin levels in nursing women were not influenced by chronic oestradiol administration .","gene":["prolactin"],"gene_indices_start":[21],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3647,"text":"Osteocalcin ( serum bone-Gla protein , sBGP ) , serum alkaline phosphatase ( sAP ) and urinary hydroxyproline \/ creatinine ratio ( uOH-Prol \/ creatinine ) have been measured in 21 patients with primary hyperparathyroidism ( PHPT ) and in nine patients with hypercalcaemia of malignancy ( HM ) .","gene":["serum bone-Gla protein","sAP","Osteocalcin","serum alkaline phosphatase","sBGP"],"gene_indices_start":[0,14,39,48,77],"gene_indices_end":[11,36,43,74,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3652,"text":"In contrast , the Anabaena strain 7120 leuA gene did not complement the nifV mutation of R229I efficiently .","gene":["leuA","nifV mutation"],"gene_indices_start":[39,72],"gene_indices_end":[43,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3653,"text":"Y15170 ( Surf-2 , Surf-4 ) , Y15171 ( Surf-3 , Surf-1 , Surf-6 ) , and Y15172 ( Surf-5 . ) ]","gene":["Surf-4","Y15172","Surf-2","Surf-3","Y15170","Y15171","Surf-5","Surf-1","Surf-6"],"gene_indices_start":[0,9,18,29,38,47,56,71,80],"gene_indices_end":[6,15,24,35,44,53,62,77,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3656,"text":"Anti-HBc production of PBMC was enhanced remarkably in this case .","gene":["Anti-HBc"],"gene_indices_start":[0],"gene_indices_end":[8],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3657,"text":"The RNA-binding and RNA-DNA helicase activities of the Escherichia coli transcription termination factor rho have been investigated using natural RNA molecules that are 255 and 391 nucleotide residues in length and that contain the trp t' rho-dependent termination sequence of E . coli .","gene":["Escherichia coli transcription termination factor rho","trp t' rho-dependent termination sequence","RNA-DNA helicase"],"gene_indices_start":[20,55,232],"gene_indices_end":[36,108,273],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3660,"text":"Using adenoviral transfer of IkappaBalpha ( IkappaBalpha overexpression ) , the production of TNF-alpha induced by whole GBS was inhibited by only 20% .","gene":["IkappaBalpha","IkappaBalpha","TNF-alpha"],"gene_indices_start":[29,44,94],"gene_indices_end":[41,56,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3661,"text":"In the present study , we have isolated and sequenced several p15E cDNA gene fragments amplified by means of polymerase chain reaction ( PCR ) from parental ( P815 ) and xenogenized ( P815 \/ DTIC ) tumour cells .","gene":["p15E cDNA gene fragments","polymerase"],"gene_indices_start":[62,109],"gene_indices_end":[86,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3663,"text":"4 . 26 + \/ - 1 . 54 mmol \/ l , P < 0 . 01 ) , and systolic BP responses to intravenous norepinephrine and angiotensin II were significantly higher on glibenclamide than on metformin ( P < 0 . 02 and P < 0 . 05 , respectively ) .","gene":["angiotensin II"],"gene_indices_start":[106],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3665,"text":"Interactions between adrenergics , adrenolytics and monoamine oxidase inhibitors .","gene":["monoamine oxidase"],"gene_indices_start":[52],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3666,"text":"Leukocyte cultures , prepared from blood drawn from these 18 children at 6 months of age , produced lower yields of IFN than those of the remaining 53 children , when stimulated with adenovirus ( P < 0 . 001 ) , coronavirus ( P < 0 . 001 ) or rhinovirus ( P = 0 . 002 ) .","gene":["IFN"],"gene_indices_start":[116],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3667,"text":"Using the yeast two-hybrid system to screen for proteins which interact with Tax1 , we isolated the B subunit of the CCAAT binding protein NF-Y from a HeLa cDNA library .","gene":["CCAAT binding protein","NF-Y","Tax1"],"gene_indices_start":[77,117,139],"gene_indices_end":[81,138,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3670,"text":"Band-shift assays and DNase I footprinting experiments using purified 42 kDa repressor isoform confirmed that CIRs 5 and 6 were indeed the targets for binding of this protein .","gene":["CIRs 5 and 6","DNase I"],"gene_indices_start":[22,110],"gene_indices_end":[29,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3671,"text":"Immediate-early transcription from the channel catfish virus genome : characterization of two immediate-early transcripts .","gene":["immediate-early transcripts"],"gene_indices_start":[94],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3675,"text":"Interaction of HRI with Hsc70 was required for the transformation of HRI , as the Hsc70 antagonist clofibric acid inhibited the folding of HRI into a mature-competent conformation .","gene":["Hsc70","HRI","Hsc70","HRI","HRI"],"gene_indices_start":[15,24,69,82,139],"gene_indices_end":[18,29,72,87,142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3676,"text":"The levels of transactivation are correlated with the respective binding affinities of the response elements ( IRper-1 > DR-4 > IRhsp-1 ) .","gene":["DR-4","IRhsp-1","IRper-1"],"gene_indices_start":[111,121,128],"gene_indices_end":[118,125,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3681,"text":"Here we describe the cloning , tissue-specific expression pattern , and functional characterization of two novel TEF-1 isoforms , TEF-1beta and TEF-1gamma .","gene":["TEF-1gamma","TEF-1beta","TEF-1 isoforms"],"gene_indices_start":[113,130,144],"gene_indices_end":[127,139,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3683,"text":"Max : functional domains and interaction with c-Myc .","gene":["Max","c-Myc"],"gene_indices_start":[0,46],"gene_indices_end":[3,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3684,"text":"Conversely , treatment of human protein-tyrosine phosphatase alpha-overexpressing cells with phenylarsine oxide led to a loss of the constitutive NF-kappa B activity .","gene":["NF-kappa B","human protein-tyrosine phosphatase"],"gene_indices_start":[26,146],"gene_indices_end":[60,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3688,"text":"Using immunogold electron microscopy , we found that p58 \/ p45 and p54 are localized on both sides of the nuclear pore complex , like p62 .","gene":["p58 \/ p45","p62","p54"],"gene_indices_start":[53,67,134],"gene_indices_end":[62,70,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3689,"text":"HEF1 , p130 ( Cas ) , and Efs \/ Sin constitute a family of multidomain docking proteins that have been implicated in coordinating the regulation of cell adhesion .","gene":["HEF1","Efs \/ Sin","p130 ( Cas )"],"gene_indices_start":[0,7,26],"gene_indices_end":[4,19,35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3691,"text":"Among mammalian HSFs , HSF1 has been shown to be important for regulation of the heat-induced stress gene expression , whereas the function of HSF2 in stress response is unclear .","gene":["HSF2","heat-induced stress gene","HSF1","mammalian HSFs"],"gene_indices_start":[6,23,81,143],"gene_indices_end":[20,27,105,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3692,"text":"In all cells , the accumulation of high Dsg protein levels required calcium and was not observed in low calcium ( 0 . 05-0 . 07 mM ) media .","gene":["Dsg protein"],"gene_indices_start":[40],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3693,"text":"Point mutations that suppressed the in vitro binding of NF-Y to the internal palindromic arm reduced the activity of the resident P4 promoter , while those preventing complex formation with USF did not , as determined by transient expression assays using the luciferase reporter gene .","gene":["luciferase","USF","P4 promoter","NF-Y"],"gene_indices_start":[56,130,190,259],"gene_indices_end":[60,141,193,269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3696,"text":"We found that the SOCS box interacted with Cullin-2 and promoted ubiquitination of TEL-JAK2 .","gene":["TEL-JAK2","SOCS box","Cullin-2"],"gene_indices_start":[18,43,83],"gene_indices_end":[26,51,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3697,"text":"TPA and TGF-beta 1 did not markedly affect the activities of the 72-kDa enzyme .","gene":["TGF-beta 1"],"gene_indices_start":[8],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3699,"text":"AMY-1 was localized in the cytoplasm in cells expressing c-myc at low levels , but in the nucleus in the cells of a high c-myc expression in transiently transfected cells .","gene":["c-myc","c-myc","AMY-1"],"gene_indices_start":[0,57,121],"gene_indices_end":[5,62,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3707,"text":"These studies suggest an additional component or cellular environment is required for SPRK activation by Cdc42 .","gene":["SPRK","Cdc42"],"gene_indices_start":[86,105],"gene_indices_end":[90,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3708,"text":"The response of serum GH to arginine infusion was normal , while that to insulin-induced hypoglycemia was poor .","gene":["serum GH"],"gene_indices_start":[16],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3710,"text":"NDRF \/ NeuroD2 was co-precipitated with PKN from the lysate of COS-7 cells transfected with both expression constructs for NDRF \/ NeuroD2 and PKN .","gene":["NDRF \/ NeuroD2","NDRF \/ NeuroD2","PKN","PKN"],"gene_indices_start":[0,40,123,142],"gene_indices_end":[14,43,137,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3711,"text":"Effect of trauma on plasma glucagon and insulin concentrations in sheep .","gene":["plasma glucagon","insulin"],"gene_indices_start":[20,40],"gene_indices_end":[35,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3713,"text":"In vitro protein retention experiments in which Hsp90 heterocomplexes were precipitated resulted in coprecipitation of Cns1 .","gene":["Cns1","Hsp90 heterocomplexes"],"gene_indices_start":[48,119],"gene_indices_end":[69,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3714,"text":"We have identified two functional elements , both located downstream from the TATA motif , that control Id4 promoter activity .","gene":["Id4 promoter"],"gene_indices_start":[104],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3716,"text":"This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date .","gene":["AHC deletion mutants"],"gene_indices_start":[67],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3718,"text":"The xylose isomerase-encoding gene ( xylA ) of Clostridium thermosaccharolyticum : cloning , sequencing and phylogeny of XylA enzymes .","gene":["xylose isomerase-encoding gene","XylA enzymes","xylA"],"gene_indices_start":[4,37,121],"gene_indices_end":[34,41,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3719,"text":"Two disulphide bridges , which are conserved in all spermadhesin molecules and many CUB domains , crosslink loop LA and strand beta 4 and loops LE and LG , respectively , at opposite edges of the same face of the domain .","gene":["CUB domains"],"gene_indices_start":[84],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3721,"text":"Detection of anti-lymphocyte antibodies using the immunoperoxidase antiglobulin technic .","gene":["immunoperoxidase","antiglobulin"],"gene_indices_start":[50,67],"gene_indices_end":[66,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3722,"text":"Remarkably , both TTD-A and XP-D defects are associated with subunits of TFIIH , a basal transcription factor with a second function in DNA repair .","gene":["TFIIH"],"gene_indices_start":[73],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3724,"text":"The skp1+ gene is not essential .","gene":["skp1+ gene"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3725,"text":"Sequence analysis of the sMtCK genomic upstream sequences reveals a typical TATAA box within the 80 base pairs ( bp ) that , by transfection experiments , are sufficient to promote expression of chimeric plasmids with the chloramphenicol acetyltransferase reporter .","gene":["sMtCK genomic upstream sequences","chloramphenicol acetyltransferase reporter","sMtCK genomic upstream sequences","chloramphenicol acetyltransferase reporter"],"gene_indices_start":[25,222],"gene_indices_end":[48,57,256,264],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3726,"text":"To evaluate the effects of propranolol on myocardial metabolism after coronary reperfusion , serial measurements of myocardial creatine kinase ( CK ) and calcium ( Ca ) contents and CK and lactic acid ( LA ) concentrations in coronary sinus blood were carried out in 33 open-chest dogs .","gene":["myocardial creatine kinase","CK","CK"],"gene_indices_start":[116,145,182],"gene_indices_end":[142,147,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3727,"text":"Titration of the human and porcine proteins with 2-nitro-5-thiosulfabenzoate indicates that membrane dipeptidase additionally possesses two intrachain disulfide bonds .","gene":["membrane dipeptidase"],"gene_indices_start":[92],"gene_indices_end":[112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3728,"text":"The first identification of the active 37LRP \/ p40 gene presented in this study is a critical step toward the isolation of the corresponding human gene and the understanding of the molecular mechanisms involved in the up-regulation of its expression during tumor invasion and metastasis .","gene":["active 37LRP \/ p40 gene"],"gene_indices_start":[32],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3732,"text":"The lack of the C2 domain of the Ca ( 2+ ) -dependent PKCs and the presence of a unique NH2-terminal sequence with a potential signal peptide and a transmembrane domain suggest that PKC mu is a novel member of the subgroup of atypical PKCs .","gene":["PKC mu","PKCs","Ca ( 2+ ) -dependent PKCs","C2 domain"],"gene_indices_start":[16,33,182,235],"gene_indices_end":[25,58,188,239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3733,"text":"However , whether or not nonsense codon recognition within TPI transcripts takes place prior to or after splicing remained unresolved .","gene":["TPI transcripts"],"gene_indices_start":[59],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3736,"text":"Molecular analysis of the pRA2 partitioning region : ParB autoregulates parAB transcription and forms a nucleoprotein complex with the plasmid partition site , parS .","gene":["parS","ParB","parAB"],"gene_indices_start":[53,72,160],"gene_indices_end":[57,77,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3738,"text":"A mutation in the C domain of Rb , L901Q , has been identified that completely abolishes cdk4 \/ D1 phosphorylation of the isolated C domain .","gene":["Rb","cdk4 \/ D1"],"gene_indices_start":[30,89],"gene_indices_end":[32,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3739,"text":"Specific clotting factor assays showed an isolated deficiency of factor X ranging from 7 to 12 per cent on three determinations .","gene":["factor X"],"gene_indices_start":[65],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3741,"text":"These data should be useful in developing reagents for heterozygote detection and prenatal diagnosis of 11 beta-hydroxylase deficiency , the second most frequent cause of congenital adrenal hyperplasia .","gene":["11 beta-hydroxylase"],"gene_indices_start":[104],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3742,"text":"These exons , further identified as exons 9 , 10 , and 11 , together encode the 37 amino acid residues present in alpha s1-casein variant A but missing in variant F .","gene":["alpha s1-casein variant A"],"gene_indices_start":[114],"gene_indices_end":[139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3744,"text":"Examination of neurohumoral factors revealed a hyperactive sympathetic nervous system and an increase in plasma renin activity .","gene":["renin"],"gene_indices_start":[112],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3746,"text":"This investigation was undertaken to determine whether consuming several small feedings of preexercise carbohydrate ( CHO ) , rather than a single bolus , would affect blood glucose and insulin responses during rest and exercise .","gene":["insulin"],"gene_indices_start":[186],"gene_indices_end":[193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3747,"text":"A triple Ser-- > Ala mutant form of yeast eIF-2 alpha was found to be no longer phosphorylated by either of the yeast ( or mammalian ) casein kinase activities in vitro .","gene":["casein kinase","eIF-2 alpha"],"gene_indices_start":[42,135],"gene_indices_end":[53,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3748,"text":"HexA71 negatively affects RpoS , as the levels of this alternative sigma factor are higher in the HexA- mutant than in the HexA+ strain .","gene":["RpoS","sigma factor","HexA+","HexA- mutant","HexA71"],"gene_indices_start":[0,26,67,98,123],"gene_indices_end":[6,30,79,110,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3749,"text":"Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity .","gene":["repressor proteins BP1","beta globin gene flanking region","BP2"],"gene_indices_start":[51,78,113],"gene_indices_end":[73,81,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3750,"text":"To study a possible functional role of this putative chicken ICS , an oligonucleotide spanning the upstream sequences of the BF-IV gene ( -174 \/ -194 ) was cloned singly or in multiple copies before the herpes TK promoter controlling the chloramphenicol acetyl transferase ( CAT ) gene ( pBLCAT2 ) .","gene":["CAT","TK promoter","BF-IV gene","chloramphenicol acetyl transferase","ICS"],"gene_indices_start":[61,125,210,238,275],"gene_indices_end":[64,135,221,272,278],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3751,"text":"The results suggested that , depending upon the cell type , gene cotransfer using aminoglycoside resistance as a selectable marker may seriously perturb important cellular control mechanisms such as the PKC pathway leading to activation of gene expression .","gene":["PKC"],"gene_indices_start":[203],"gene_indices_end":[206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3753,"text":"With the increasing use of ACE inhibitors , the incidence of rare adverse effects such as potentially lethal pancreatitis is likely to increase .","gene":["ACE"],"gene_indices_start":[27],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3755,"text":"No significant differences were found in relation to Type A behaviour and beta-adrenoceptor blockade .","gene":["beta-adrenoceptor"],"gene_indices_start":[74],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3757,"text":"Overexpression of EFG1 in C . albicans leads to enhanced filamentous growth in the form of extended pseudohyphae in liquid and on solid media .","gene":["EFG1"],"gene_indices_start":[18],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3758,"text":"The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae .","gene":["26S rRNA binding ribosomal protein","bacterial protein L11"],"gene_indices_start":[4,53],"gene_indices_end":[38,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3759,"text":"An unexpected finding was the presence at position -403 to -385 of a putative dioxin responsive element , a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene ( CYPIA1 ) and other genes involved in detoxification \/ activation of polycyclic aromatic hydrocarbons .","gene":["dioxin responsive element","CYPIA1","cytochrome P450IA1 gene"],"gene_indices_start":[78,183,209],"gene_indices_end":[103,206,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3761,"text":"APOE-epsilon4 count predicts age when prevalence of AD increases , then declines : the Cache County Study .","gene":["APOE-epsilon4"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3762,"text":"In contrast , resensitization of a sequestration-impaired beta2AR mutant ( Y326A ) was reestablished following the overexpression of either GRK2 or beta-arrestin 1 .","gene":["GRK2","beta2AR mutant ( Y326A )","beta-arrestin 1"],"gene_indices_start":[58,140,148],"gene_indices_end":[82,144,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3769,"text":"Recently , a distantly related UmuC-homolog , DinB , has also been identified in E . coli .","gene":["DinB","UmuC-homolog"],"gene_indices_start":[31,46],"gene_indices_end":[43,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3770,"text":"Molecular cloning of human cDNA encoding a novel beta1 , 6-N-acetylglucosaminyltransferase forming core 2 and core 4 .","gene":["beta1 , 6-N-acetylglucosaminyltransferase"],"gene_indices_start":[49],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3772,"text":"The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors .","gene":["ets motifs","murine cytochrome c oxidase subunit IV gene","GABP-related transcription factors"],"gene_indices_start":[31,106,130],"gene_indices_end":[74,116,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3774,"text":"Expression of SREBP-1a stimulated StAR promoter activity in the context of COS-1 cells and human granulosa-lutein cells .","gene":["StAR promoter","SREBP-1a"],"gene_indices_start":[14,34],"gene_indices_end":[22,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3775,"text":"Serum levels of albumin , globulin , and coagulation protein activity were measured preshock , postshock , and daily for 3 days ; skin lymph levels were measured on Day 3 .","gene":["albumin","coagulation protein","globulin"],"gene_indices_start":[16,26,41],"gene_indices_end":[23,34,60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3777,"text":"The Drosophila clathrin heavy chain gene : clathrin function is essential in a multicellular organism .","gene":["clathrin","clathrin heavy chain"],"gene_indices_start":[15,43],"gene_indices_end":[35,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3788,"text":"Radiolabeled biantennary N-glycans synthesized by Pro ( - ) 5Lec20 were proportionately less ricin-bound than similar species from parental CHO cells , and Lec20 cell extracts had a markedly reduced ability to transfer Gal to GlcNAc-terminating acceptors .","gene":["Pro ( - ) 5Lec20"],"gene_indices_start":[50],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3789,"text":"In Saccharomyces cerevisiae the cAMP-dependent kinases ( PKAs ) promote cytoplasmic growth and modulate the growth-regulated mechanism triggering the begin of DNA synthesis .","gene":["cAMP-dependent kinases","PKAs"],"gene_indices_start":[32,57],"gene_indices_end":[54,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3790,"text":"In marked contrast to AgfA , none of the chimeric SefA proteins were expressed or assembled into fimbriae .","gene":["AgfA","chimeric SefA proteins"],"gene_indices_start":[22,41],"gene_indices_end":[26,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3792,"text":"Heparin had no effect on rAC-st myosin light chain phosphatase activity , while the B subunit-containing forms were stimulated 2-3-fold .","gene":["rAC-st myosin light chain phosphatase"],"gene_indices_start":[25],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3794,"text":"Studies using the yeast two-hybrid system also did not provide evidence for the formation of a VDR-TR protein-protein interaction .","gene":["VDR-TR"],"gene_indices_start":[95],"gene_indices_end":[101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3795,"text":"The frequency of lactase phenotypes in Aymara children .","gene":["lactase phenotypes"],"gene_indices_start":[17],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3796,"text":"( iii ) In these cells , PKCbeta plays a unique Ras-independent role in mediating insulin but not EGF or other growth factor mitogenic signals .","gene":["EGF","growth factor","insulin","PKCbeta"],"gene_indices_start":[25,82,98,111],"gene_indices_end":[32,89,101,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3797,"text":"Adenylosuccinate synthetase ( IMP : L-aspartate ligase ( GDP ) , EC 6 . 3 . 4 . 4 ) plays an important role in purine biosynthesis catalyzing the GTP-dependent conversion of IMP to AMP .","gene":["L-aspartate ligase","Adenylosuccinate synthetase"],"gene_indices_start":[0,36],"gene_indices_end":[27,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3799,"text":"These experiments delineate a 186-bp , EBNA-2-responsive cell DNA fragment and provide firm evidence that EBNA-2 transactivates transcription of cell genes .","gene":["EBNA-2"],"gene_indices_start":[106],"gene_indices_end":[112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3800,"text":"Northern blot analysis demonstrated that the STORP gene has a ubiquitous pattern of expression similar to that of the PML gene .","gene":["PML gene","STORP gene"],"gene_indices_start":[45,118],"gene_indices_end":[55,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3801,"text":"These data provide strong evidence that E2F or an E2F-related transcription factor is involved in the regulation of nonmuscle myosin expression .","gene":["E2F-related transcription factor","E2F","nonmuscle myosin"],"gene_indices_start":[40,50,116],"gene_indices_end":[43,82,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3802,"text":"In Saccharomyces cerevisiae , entry into mitosis requires activation of the cyclin-dependent kinase Cdc28 in its cyclin B ( Clb ) -associated form .","gene":["Clb","cyclin B","cyclin-dependent kinase Cdc28"],"gene_indices_start":[76,113,124],"gene_indices_end":[105,121,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3803,"text":"Similar data were also obtained when either dominant negative EGFR-CD533 or dominant negative Ras N17 were used to block MAPK activation .","gene":["MAPK","dominant negative EGFR-CD533","dominant negative Ras N17"],"gene_indices_start":[44,76,121],"gene_indices_end":[72,101,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3805,"text":"By far-Western analysis and coimmunoprecipitation studies , we demonstrate that ZNF74 interacts , via its zinc finger domain , with the hyperphosphorylated largest subunit of RNA polymerase II ( pol IIo ) but not with the hypophosphorylated form .","gene":["pol IIo","ZNF74","RNA polymerase II"],"gene_indices_start":[80,175,195],"gene_indices_end":[85,192,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3807,"text":"Genetic and biochemical evidence suggests that v-Crk can induce transformation of chicken embryo fibroblasts by influencing the activity of cellular proteins involved in growth regulation .","gene":["v-Crk"],"gene_indices_start":[47],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3808,"text":"Heating cells to 43 degrees C decreased the amount of newly synthesized rRNA to less than 5% of the control level and led to greater than 95% inhibition of transcription termination at a region 355 to 362 nucleotides downstream of the 3' end of 28S rRNA , with readthrough continuing into the next transcription unit .","gene":["rRNA","28S rRNA"],"gene_indices_start":[72,245],"gene_indices_end":[76,253],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3811,"text":"Protein cHMGI binds preferentially to AT-rich DNA with a half-saturation value of 1 . 1 nM .","gene":["Protein cHMGI"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3815,"text":"In the mouse , CtBP1 is expressed from embryo to adult , but CtBP2 is mainly expressed during embryogenesis .","gene":["CtBP1","CtBP2"],"gene_indices_start":[15,61],"gene_indices_end":[20,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3817,"text":"Rat liver catalase is sorted to peroxisomes by its C-terminal tripeptide Ala-Asn-Leu , not by the internal Ser-Lys-Leu motif .","gene":["Ala-Asn-Leu","Rat liver catalase","internal Ser-Lys-Leu motif"],"gene_indices_start":[0,73,98],"gene_indices_end":[18,84,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3818,"text":"Evidence for a role of endogenous corticotropin-releasing factor in cold , ether , immobilization , and traumatic stress .","gene":["endogenous corticotropin-releasing factor"],"gene_indices_start":[23],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3821,"text":"Dd PK1 RNA decreases after 6 h of starvation to re-accumulate once the cells have aggregated .","gene":["Dd PK1 RNA"],"gene_indices_start":[0],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3823,"text":"Redistribution of mannosidase I was also observed in cells incubated at 15 degrees C .","gene":["mannosidase I"],"gene_indices_start":[18],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3825,"text":"The second transcript , rhis4l , is bicistronic .","gene":["rhis4l"],"gene_indices_start":[24],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3827,"text":"In support of this interpretation we demonstrate that MQ9b binds strongly 5 of 17 motif-positive , pathogen-derived synthetic peptides .","gene":["MQ9b"],"gene_indices_start":[54],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3828,"text":"Human expressed sequence tag clones were identified by sequence similarity to mammalian and yeast oligosaccharide-processing mannosidases , and the full-length coding region of the putative mannosidase homolog was isolated by a combination of 5'-rapid amplification of cDNA ends and direct polymerase chain reaction from human placental cDNA .","gene":["mammalian and yeast oligosaccharide-processing mannosidases","mannosidase homolog","polymerase"],"gene_indices_start":[78,190,290],"gene_indices_end":[137,209,300],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3829,"text":"Irradiation of human blood platelets with UV-A in vitro impairs their ability to aggregate after challenge with collagen .","gene":["collagen"],"gene_indices_start":[112],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3832,"text":"Because all PDGFbetaR fusions described thus far result in splicing to a common exon of this gene , we performed 5'-rapid amplification of cDNA ends PCR on patient RNA .","gene":["PDGFbetaR fusions"],"gene_indices_start":[12],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3833,"text":"Here we have investigated the structural requirements and consequences of regulatory phosphorylation for the interaction between c-Jun and JNK in vivo .","gene":["c-Jun","JNK"],"gene_indices_start":[129,139],"gene_indices_end":[134,142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3837,"text":"The human cDNA was used to demonstrate that tumor necrosis factor-alpha could rapidly stimulate MARCKS gene transcription in the human promyelocytic leukemia cell line HL60 .","gene":["tumor necrosis factor-alpha","MARCKS gene"],"gene_indices_start":[44,96],"gene_indices_end":[71,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3838,"text":"We have therefore studied the molecular mechanisms of TGF-beta1 action on thyroglobulin ( TG ) gene expression by focusing our attention on TGF-beta1 regulation of thyroid-specific transcription factors .","gene":["TGF-beta1","TGF-beta1","TG","thyroglobulin"],"gene_indices_start":[54,74,90,140],"gene_indices_end":[63,87,92,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3839,"text":"The predicted receptor structure includes a cysteine-rich extracellular domain , a single hydrophobic transmembrane domain , and a predicted cytoplasmic serine \/ threonine kinase domain .","gene":["cytoplasmic serine \/ threonine kinase domain"],"gene_indices_start":[141],"gene_indices_end":[185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3843,"text":"U4 \/ U6 snRNP is one of four essential small nuclear ribonucleoprotein ( snRNP ) particles ( U1 , U2 , U5 and U4 \/ U6 ) present in the spliceosome .","gene":["spliceosome","U4 \/ U6 snRNP","small nuclear ribonucleoprotein ( snRNP ) particles ( U1 , U2 , U5 and U4 \/ U6"],"gene_indices_start":[0,39,135],"gene_indices_end":[13,117,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3846,"text":"When cotransfected in fibroblasts with a C \/ EBP alpha expression vector , reporter gene expression increased 3-fold only in the wild-type constructs .","gene":["C \/ EBP alpha"],"gene_indices_start":[41],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3847,"text":"This utilization of an intronic polyadenylation site without alternative exon usage is comparable to the mechanism whereby both secreted and membrane-bound forms of the immunoglobulin mu heavy chain are made from a single genetic locus .","gene":["immunoglobulin mu heavy chain"],"gene_indices_start":[169],"gene_indices_end":[198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3848,"text":"The characterized Y' repeated sequence families provide an experimental system in which repeated sequence interactions and subsequent evolution can be studied .","gene":["Y' repeated sequence families"],"gene_indices_start":[18],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3850,"text":"In these constructs , GUS expression was driven by promoter regions derived from the Arabidopsis alcohol dehydrogenase ( Adh1 ) , maize ubiquitin ( Ubi1 ) , rice actin ( Act1 ) and CaMV 35S genes .","gene":["Act1","Adh1","maize ubiquitin","rice actin","CaMV 35S genes","Arabidopsis alcohol dehydrogenase","GUS","Ubi1"],"gene_indices_start":[22,85,121,130,148,157,170,181],"gene_indices_end":[25,118,125,145,152,167,174,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3852,"text":"While no obvious transmembrane regions were identified , several short hydrophobic amino acid stretches were found to be localized in and around the Pro II region , and these may be responsible for attachment of precursors to membranes .","gene":["Pro II region"],"gene_indices_start":[149],"gene_indices_end":[162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3853,"text":"In addition , carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase-like ( JH2 ) and kinase ( JH1 ) domains ( approximately 70% identity ) .","gene":["mammalian JAK1","kinase","JH2","carp JAK1","kinase-like","JH1"],"gene_indices_start":[14,58,85,99,109,118],"gene_indices_end":[23,72,96,102,115,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3854,"text":"U73 contains C , D and D' boxes and a 12-nucleotide antisense complementarity to the 28S ribosomal RNA .","gene":["U73","28S ribosomal RNA"],"gene_indices_start":[0,85],"gene_indices_end":[3,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3856,"text":"By contrast , deletion of this Ras-binding site did not diminish activation of Raf-1 kinase by Src , implying that Src and Ras can activate Raf-1 through independent mechanisms .","gene":["Raf-1","Src","Ras-binding site","Raf-1 kinase","Src","Ras"],"gene_indices_start":[31,79,95,115,123,140],"gene_indices_end":[47,91,98,118,126,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3858,"text":"The Stat5b mRNA has a size of 5 . 6 kb and encodes a protein of 786 amino acids .","gene":["Stat5b mRNA"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3859,"text":"Expression of the wt1 gene via transient transfection in COS-1 cells revealed a 52 kDa protein which was immunoprecipitated by both the N-terminal- and C-terminal-specific antisera .","gene":["wt1 gene"],"gene_indices_start":[18],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3860,"text":"Cotransfection of either construct with plasmids encoding PKI ( 1-31 ) inhibits cAMP-stimulated but not basal- or phorbol ester-stimulated expression .","gene":["PKI ( 1-31 )"],"gene_indices_start":[58],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3862,"text":"Tensile bond strengths between resin composite and bovine dentin using dentin adhesive systems ( Clearfil Liner Bond II : LB II ; Scotchbond Multi-Purpose : MP ) bonding systems showed a large scatter among students and dentists .","gene":["dentin","bovine dentin"],"gene_indices_start":[51,71],"gene_indices_end":[64,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3865,"text":"Prominent protein kinase cascades are those that activate mitogen-activated protein ( MAP ) kinases .","gene":["mitogen-activated protein ( MAP ) kinases","protein kinase cascades"],"gene_indices_start":[10,58],"gene_indices_end":[33,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3870,"text":"Hydrocortisone caused lymphopenia and inhibited the blastogenic response of peripheral blood lymphocytes to phytohemagglutinin and concanavalin A mitogens .","gene":["phytohemagglutinin","concanavalin A"],"gene_indices_start":[108,131],"gene_indices_end":[126,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3872,"text":"A subset of these DMP1 recognition sequences containing a GGA trinucleotide core can also function as Ets-responsive elements .","gene":["Ets-responsive elements","DMP1 recognition sequences"],"gene_indices_start":[18,102],"gene_indices_end":[44,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3873,"text":"Ab-MLV strains expressing P70 \/ S2 failed to transform NIH 3T3 cells and demonstrated a greatly reduced capacity to mediate signaling events associated with the Ras-dependent mitogen-activated protein ( MAP ) kinase pathway .","gene":["P70 \/ S2","Ras-dependent mitogen-activated protein ( MAP ) kinase"],"gene_indices_start":[26,161],"gene_indices_end":[34,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3874,"text":"The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein ( APP ) is regulated by two blocks of upstream sequences .","gene":["gene encoding Alzheimer beta-amyloid precursor protein","APP"],"gene_indices_start":[29,86],"gene_indices_end":[83,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3875,"text":"High-affinity site-specific DNA binding by POU domain transcription factors requires both the POU-specific and the POU-homeodomain .","gene":["POU domain","POU-homeodomain"],"gene_indices_start":[43,115],"gene_indices_end":[53,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3876,"text":"These utilisation data imply annual drug costs in the range of $US 480 , 000 to $US 3 , 600 , 000 for TNF antagonists for RA per 1 million population .","gene":["TNF"],"gene_indices_start":[102],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3878,"text":"Nucleotide sequence analysis revealed that TAR-binding protein is very similar to the CREB2 protein .","gene":["TAR-binding protein","CREB2 protein"],"gene_indices_start":[43,86],"gene_indices_end":[62,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3882,"text":"A 385 bp Glucocorticoid Response Unit ( GRU ) was identified whose glucocorticoid induction was enhanced by dibutyryl-cAMP and reduced by phorbol esters .","gene":["385 bp Glucocorticoid Response Unit","GRU"],"gene_indices_start":[2,40],"gene_indices_end":[37,43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3884,"text":"In the absence of Mg2+ , a hydrophobic exonuclease site dominates over the polymerase site for possession of the primer terminus .","gene":["polymerase site","exonuclease site"],"gene_indices_start":[39,75],"gene_indices_end":[55,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3885,"text":"Both carbachol ( 100 microM ) and EGF ( 10 nM ) induced Ras activation .","gene":["Ras","EGF"],"gene_indices_start":[34,56],"gene_indices_end":[37,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3887,"text":"These results suggest that low concentrations of IL-1 beta may be useful for nonsurgical treatment of human vitreous hemorrhage .","gene":["IL-1 beta"],"gene_indices_start":[49],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3888,"text":"Results of the official inspection of the commercial anti-inflammatory enzyme preparations containing chymotrypsin and trypsin by means of modified NF 13 methods .","gene":["chymotrypsin","trypsin"],"gene_indices_start":[102,119],"gene_indices_end":[114,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3889,"text":"T cell leukemia-associated human Notch \/ translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells .","gene":["Notch homologue","nuclear factor-kappa B proteins"],"gene_indices_start":[66,140],"gene_indices_end":[81,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3891,"text":"A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins .","gene":["G protein","Galphao","Galphai1"],"gene_indices_start":[20,32,78],"gene_indices_end":[27,40,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3893,"text":"Conformational changes of the ferric uptake regulation protein upon metal activation and DNA binding ; first evidence of structural homologies with the diphtheria toxin repressor .","gene":["diphtheria toxin repressor"],"gene_indices_start":[152],"gene_indices_end":[178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3896,"text":"Cbl constitutively interacts with the SH3 domains of Grb2 , with a preference for the amino-terminal domain , and is in this way recruited to Shc upon BCR stimulation .","gene":["SH3 domains","Cbl","Grb2","Shc","BCR"],"gene_indices_start":[0,38,53,142,151],"gene_indices_end":[3,49,57,145,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3901,"text":"By creating Pax-6-BSAP fusion proteins , we were able to identify a short amino acid stretch in the N-terminal part of the paired domain which is responsible for these differences in DNA-binding specificity .","gene":["Pax-6-BSAP fusion proteins"],"gene_indices_start":[12],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3907,"text":"The catenins bind to APC and E-cadherin in a similar fashion , but APC and E-cadherin do not associate with each other either in the presence or absence of catenins .","gene":["APC","catenins","E-cadherin","catenins","E-cadherin","APC"],"gene_indices_start":[4,21,29,67,75,156],"gene_indices_end":[12,24,39,70,85,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3908,"text":"The rhaB transcription start site was mapped to -24 relative to the start of translation .","gene":["rhaB transcription start site"],"gene_indices_start":[4],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3909,"text":"Despite the activation of these intracellular signaling molecules , PDGF beta receptor activation elicited no detectable effect on cell proliferation or differentiation .","gene":["PDGF beta receptor"],"gene_indices_start":[68],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3910,"text":"A fusion protein composed of beta-galactosidase and full-length Ahr translocates from the cytoplasm to the nucleus in a ligand-dependent manner .","gene":["beta-galactosidase","full-length Ahr"],"gene_indices_start":[29,52],"gene_indices_end":[47,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3911,"text":"In strains lacking tup11 and tup12 , the atf1-pcr1 transcriptional activator continues to play a central role in fbp1-lacZ expression ; however , spc1 MAPK phosphorylation of atf1 is no longer essential for its activation .","gene":["spc1 MAPK","atf1","fbp1-lacZ","tup11","atf1-pcr1 transcriptional activator","tup12"],"gene_indices_start":[19,29,41,113,146,175],"gene_indices_end":[24,34,76,122,155,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3912,"text":"In contrast to full-length E2F-3 , which is expressed only at the G1 \/ S boundary , E2F-3B is detected throughout the cell cycle with peak levels in GO where it is associated with Rb .","gene":["full-length E2F-3","E2F-3B"],"gene_indices_start":[15,84],"gene_indices_end":[32,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3913,"text":"A 5 . 8S-like structure is present within the 5'-terminal region of all three fungal mitochondrial LSU rRNAs ; in contrast , no 4 . 5S-like structure is evident at the 3' end of these molecules .","gene":["5 . 8S-like structure","fungal mitochondrial LSU rRNAs","4 . 5S-like structure"],"gene_indices_start":[2,78,128],"gene_indices_end":[23,108,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3914,"text":"Phenotypic changes induced by wild type and variant c-src genes carrying C-terminal sequence alterations .","gene":["wild type and variant c-src genes"],"gene_indices_start":[30],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3915,"text":"These results suggest that members of the ATF family are involved in mediating the transcriptional regulation of the KGF gene in response to extracellular stimuli via a novel CRE regulatory element .","gene":["KGF gene","ATF family","CRE regulatory element"],"gene_indices_start":[42,117,175],"gene_indices_end":[52,125,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3916,"text":"Unusual two-domain arginine kinases ( AKs ) arose independently at least two times during molecular evolution of phosphagen kinases : AKs from the primitive sea anemone Anthopleurura japonicus and from the clam Pseudocardium sachalinensis .","gene":["AKs","phosphagen kinases","AKs","two-domain arginine kinases"],"gene_indices_start":[8,38,113,134],"gene_indices_end":[35,41,131,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3917,"text":"Stable expression of the chimeric alpha i ( 54 ) \/ s polypeptide in Chinese hamster ovary ( CHO ) cells constitutively increased both cAMP synthesis and cAMP-dependent protein kinase activity .","gene":["cAMP-dependent protein kinase"],"gene_indices_start":[153],"gene_indices_end":[182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3918,"text":"Ca2+ decreased Zn2+ binding in S100 beta but it did not influence binding to MRP14 , suggesting that the Zn2+ binding site was distinct from and independent of the two Ca2+ binding domains .","gene":["MRP14","S100 beta"],"gene_indices_start":[31,77],"gene_indices_end":[40,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3919,"text":"However , rapamycin inhibited proliferation of Ba \/ F3-EpoRgp55 but not of MEL cells despite inhibition of p70 S6 kinase activity in both cells .","gene":["p70 S6 kinase"],"gene_indices_start":[107],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3920,"text":"Further , the PIP2 content of the 85-90 kDa protein appeared to decrease with CSF-1 treatment .","gene":["CSF-1","CSF-1"],"gene_indices_start":[78],"gene_indices_end":[78,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3921,"text":"Experimental ischemic heart disease induced by thromboxane A2 in rabbits .","gene":["thromboxane A2"],"gene_indices_start":[47],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3922,"text":"This spindle defect of pds1 mutants results from a temperature-sensitive step that occurs around the G1 \/ S boundary about the time of spindle assembly .","gene":["pds1 mutants"],"gene_indices_start":[23],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3925,"text":"Serum lipids and lipoproteins of 29 insulin dependent diabetic children have been determined and related to the metabolic status of the patients .","gene":["insulin"],"gene_indices_start":[36],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3926,"text":"Since general regulatory factor I ( GRFI ) \/ repressor \/ activator site binding protein 1 ( RAP1 ) \/ translation upstream factor ( TUF ) is believed to be an activator of MAT alpha expression , we examined whether PYK1 , which is known to be regulated by GRFI \/ RAP1 \/ TUF , is also affected by the gal11 mutation .","gene":["\/ translation upstream factor","RAP1","GRFI \/ RAP1 \/ TUF","GRFI","TUF","general regulatory factor I","\/ repressor \/ activator site binding protein 1","gal11 mutation","MAT alpha","PYK1"],"gene_indices_start":[6,36,43,92,99,131,171,214,255,299],"gene_indices_end":[33,40,89,96,128,134,180,218,272,313],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3928,"text":"LHbeta is expressed in pituitary gonadotrope cells and CGbeta is expressed in placental trophoblast cells .","gene":["LHbeta","CGbeta"],"gene_indices_start":[0,55],"gene_indices_end":[6,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3930,"text":"These results suggest that , in this experimental model , ACE inhibitors limit the arrhythmias following ischemia-reperfusion and free radical scavenging action of these drugs does not have a major contributory role in their protective effect .","gene":["ACE"],"gene_indices_start":[58],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3932,"text":"ICAM-1 has been suggested a predictor of the onset of GO .","gene":["ICAM-1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3941,"text":"This interaction is reciprocal , since C \/ EBP dimer binding to a strong C \/ EBP site leads to enhanced CREB-1 recruitment to ATF \/ CREB sites that are weakly bound by CREB .","gene":["C \/ EBP dimer","CREB-1","C \/ EBP site","ATF \/ CREB sites","CREB"],"gene_indices_start":[39,73,104,126,168],"gene_indices_end":[52,85,110,142,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3943,"text":"Mutations in the alpha-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing , RNA cleavage and transcriptional transitions .","gene":["yeast RNA polymerase III","alpha-amanitin"],"gene_indices_start":[17,75],"gene_indices_end":[31,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3944,"text":"Since very recent scanning-deletion analysis indicates that there is a critical region for activity near Cys-118 and that Cys-118 is necessary for maximal activity , we conclude that the Cys-118 residue is necessary for proper glycosylation and maximal biologic activity of GM-CSF .","gene":["GM-CSF"],"gene_indices_start":[274],"gene_indices_end":[280],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3948,"text":"Fragments and analogs of the hormone ACTH were previously shown to have beneficial effect on the outcome of head injury , while elevated levels of corticosterone ( CS ) exacerbate it .","gene":["ACTH"],"gene_indices_start":[37],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3951,"text":"Over-expression of Azf1p in the yeast cell does not influence the expression level of the mitochondrial transcription factor Mtf1p , indicating that the influence of Azf1p on the suppression of the special mitochondrial RNA polymerase mutant is an indirect one .","gene":["Azf1p","mitochondrial RNA polymerase mutant","mitochondrial transcription factor Mtf1p","Azf1p"],"gene_indices_start":[19,90,166,206],"gene_indices_end":[24,130,171,241],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3953,"text":"We have also found that the in vitro interaction between the SV40 octamer motif and the lymphoid cell-specific protein oct-B2 was negatively modulated by a component present in the nuclear extracts from several lymphoid cell lines .","gene":["lymphoid cell-specific protein oct-B2"],"gene_indices_start":[88],"gene_indices_end":[125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3954,"text":"The appearance of dyskinetic movement disorders in humans following the chronic use of levodopa or amphetamine may be a manifestation of similarly increased dopamine receptor site sensitivity within the striatum .","gene":["dopamine receptor site"],"gene_indices_start":[157],"gene_indices_end":[179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3956,"text":"DNA-STAT complexes were detected in all Bcr \/ Abl-transformed cell lines and they were supershifted by antibodies against STAT1 and STAT5 .","gene":["STAT5","STAT1","DNA-STAT complexes"],"gene_indices_start":[0,122,132],"gene_indices_end":[18,127,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3959,"text":"This brief review analyses these interactions and defines clinical settings where antibiotic-induced endotoxin release may prove to be clinically relevant .","gene":["endotoxin"],"gene_indices_start":[101],"gene_indices_end":[110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3960,"text":"These studies serve as the basis for the further characterization of the regulatory mechanism of aromatase expression in human breast cancer and ASCs .","gene":["aromatase"],"gene_indices_start":[97],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3964,"text":"Cross-reaction between a monoclonal antibody and two alpha beta T cell receptors .","gene":["alpha beta T cell receptors"],"gene_indices_start":[53],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3965,"text":"The coordinate increase in cyclin D1 and p21 had the effect of decreasing the specific but not absolute activity of cyclin D1 \/ cdk4 . p53 was not involved since CSF-1 induction of p21 was unaffected by dominant-negative p53 expression .","gene":["p21","cyclin D1","dominant-negative p53","cyclin D1 \/ cdk4","CSF-1","p21","p53"],"gene_indices_start":[27,41,116,135,162,181,203],"gene_indices_end":[36,44,132,138,167,184,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3968,"text":"Myocardial antioxidant enzymes , catalase , glutathione peroxidase and superoxide dismutase , in the MCT-treated rats were not different compared to control rats .","gene":["catalase","glutathione peroxidase","superoxide dismutase"],"gene_indices_start":[33,44,71],"gene_indices_end":[41,66,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3971,"text":"Penicillinase production in Staphylococcus aureus strains of clinical importance .","gene":["Penicillinase"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3977,"text":"The carboxy terminus of Mbp1 is sufficient for interaction with Swi6 , and the carboxy terminus of Swi6 is required for interaction with Mbp1 .","gene":["Mbp1","Swi6","Mbp1","Swi6"],"gene_indices_start":[24,64,99,137],"gene_indices_end":[28,68,103,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3979,"text":"However , L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues .","gene":["L-plastin"],"gene_indices_start":[10],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3981,"text":"Gel mobility shift and super-shift assays using liver nuclear extracts from either rat liver or DDT1MF-2 cells demonstrated that the CRE in the alpha 1B-AR gene bound CRE binding protein .","gene":["alpha 1B-AR gene","CRE binding protein","CRE"],"gene_indices_start":[133,144,167],"gene_indices_end":[136,160,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3983,"text":"A larger region upstream of human CMV dbp also mediated replication in transient assays .","gene":["human CMV dbp"],"gene_indices_start":[28],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3985,"text":"Using this method , we were able to select strong enhancer-type activation domains from the immediate early regions of two herpesviruses , namely pseudorabies virus and bovine herpesvirus 1 .","gene":["immediate early regions"],"gene_indices_start":[92],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3986,"text":"An association was demonstrated between the expression of aberrantly and \/ or alternatively spliced mdm2 mRNAs and a lack of progesterone receptor .","gene":["progesterone receptor","mdm2 mRNAs"],"gene_indices_start":[100,125],"gene_indices_end":[110,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3990,"text":"Phosphotyrosyl peptides block Stat3-mediated DNA-binding activity , gene regulation and cell transformation .","gene":["Phosphotyrosyl peptides"],"gene_indices_start":[0],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3992,"text":"G-CSF ( 480 micrograms subcutaneously ( s . c . ) ) were used in 55 and GM-CSF ( 400 micrograms s . c . ) in 28 chemotherapeutic cycles .","gene":["G-CSF","GM-CSF"],"gene_indices_start":[0,72],"gene_indices_end":[5,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3994,"text":"Specific IgE levels decreased slightly , but always remained within the pathological range .","gene":["IgE"],"gene_indices_start":[9],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3995,"text":"Mutating the E-box in the context of the 3'-flanking region confirmed that it contributes to the enhancement of transcriptional activity of the alpha1 ( I ) collagen gene promoter .","gene":["alpha1 ( I ) collagen gene promoter"],"gene_indices_start":[144],"gene_indices_end":[179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3998,"text":"To determine if the NF ( H ) promoter can be activated in a tissue specific manner during development transgenic mice containing the promoter region linked to a beta-galactosidase reporter gene were generated .","gene":["beta-galactosidase reporter gene","NF ( H ) promoter"],"gene_indices_start":[20,161],"gene_indices_end":[37,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":3999,"text":"Serum IgE levels in Tauranga children .","gene":["Serum IgE"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4001,"text":"It is considered that the recurrent annular erythema is a specific skin manifestation of SjS with anti SS-A \/ SS-B antibodies .","gene":["anti SS-A \/ SS-B antibodies"],"gene_indices_start":[98],"gene_indices_end":[125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4006,"text":"Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release .","gene":["LDH"],"gene_indices_start":[93],"gene_indices_end":[96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4009,"text":"Finally , antibody binding to site IIIa on the hCG-ectodomain complex was also hindered by an anti-peptide mAb directed against a peptide encoded by the eighth exon ( pE x 8 ) of the LHR .","gene":["hCG-ectodomain complex","anti-peptide mAb","LHR"],"gene_indices_start":[47,94,183],"gene_indices_end":[69,110,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4010,"text":"Identical c-erbB3 transcripts are expressed in normal human placental tissues .","gene":["c-erbB3 transcripts"],"gene_indices_start":[10],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4011,"text":"T-cell hybridomas , thymocytes , and T cells can be induced to undergo apoptotic cell death by activation through the T-cell receptor .","gene":["T-cell receptor"],"gene_indices_start":[118],"gene_indices_end":[133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4012,"text":"These data demonstrate the presence of a single binding site for vinculin , and at least two binding sites for FAK that are separated by an intervening stretch of 100 amino acids .","gene":["vinculin","FAK"],"gene_indices_start":[65,111],"gene_indices_end":[73,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4014,"text":"We have identified and characterized the structure of the Spec1 gene in the sea urchin Strongylocentrotus purpuratus .","gene":["Spec1 gene"],"gene_indices_start":[58],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4015,"text":"The cDNA contained an open reading frame of 1392 bp that predicted a protein of 464 amino acids and a molecular mass of 52 kDa ; this protein has 97% identity to rat liver glucokinase .","gene":["rat liver glucokinase"],"gene_indices_start":[162],"gene_indices_end":[183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4019,"text":"His carnitine palmitoyltransferase ( CPT ) I and II activities were 0 . 06 and 0 . 12 nmol \/ min \/ mg protein , as compared with a mean value of 0 . 22 + \/ - 0 . 14 and 0 . 27 + \/ - 0 . 07 nmol \/ min \/ mg protein , respectively , in control subjects .","gene":["carnitine palmitoyltransferase ( CPT ) I and II"],"gene_indices_start":[4],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4020,"text":"However , neu differentiation factor-induced heterodimers of ErbB2 and ErbB4 activated Stat5 .","gene":["ErbB2","ErbB4","neu","Stat5"],"gene_indices_start":[10,61,71,87],"gene_indices_end":[13,66,76,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4021,"text":"Coexpression of the p120 ( ctn ) protein with an N-terminal deletion , which eliminates some potential tyrosine phosphorylation sites , or the protein with a single amino acid substitution ( tyrosine at 217 to phenylalanine ) resulted in an increase in the aggregation of v-Src-transformed EL and EalphaCL cells .","gene":["p120 ( ctn ) protein"],"gene_indices_start":[20],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4023,"text":"Thus , it was confirmed that the sodium lauryl sulfate method of estimating hemoglobin concentration is an appropriate alternative to the cyanmethemoglobin method and avoids the generation of toxic wastes .","gene":["hemoglobin"],"gene_indices_start":[76],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4024,"text":"CTF1alpha , expressed in Escherichia coli , showed specific binding to the palindrome 2 DNA fragment but not to palindrome 1 or mutant palindrome 2 DNA fragments , suggesting specific binding of CTF1alpha to palindrome 2 .","gene":["CTF1alpha","CTF1alpha"],"gene_indices_start":[0,195],"gene_indices_end":[9,204],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4025,"text":"BACKGROUND : The effectiveness of monoamine oxidase inhibitors ( MAOIs ) in tricyclic resistant depression has received surprisingly little systematic study .","gene":["monoamine oxidase"],"gene_indices_start":[34],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4026,"text":"Monospecific antibodies , eluted from the beta-galactosidase fusion protein of either clone reacted with the U1 snRNP-specific A antigen .","gene":["beta-galactosidase","U1 snRNP-specific A antigen"],"gene_indices_start":[42,109],"gene_indices_end":[60,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4027,"text":"However , at 18 months of age , significantly higher levels of IgG1 ( P less than 0 . 05 ) and of IgG4 ( P less than 0 . 01 ) were found in infants with an elevated IgE ( greater than or equal to 8 . 0 kU \/ l ) than in those with a lower level .","gene":["IgG4","IgG1","IgE"],"gene_indices_start":[63,98,165],"gene_indices_end":[67,102,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4028,"text":"RNA gel retardation and competition analyses indicate that TRP-185 binding is strongly dependent on the TAR RNA loop sequences .","gene":["TAR RNA loop sequences","TRP-185"],"gene_indices_start":[59,104],"gene_indices_end":[66,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4029,"text":"Transcript analysis reveals that lethal B block substitutions reduce U6 RNA synthesis at least 10-fold in vivo and 20-fold in vitro .","gene":["B block","U6 RNA"],"gene_indices_start":[40,69],"gene_indices_end":[47,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4031,"text":"The primers were degenerate sets of oligonucleotides derived from known amino acid sequences of the PBAN precursor .","gene":["PBAN precursor"],"gene_indices_start":[100],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4037,"text":"Isoelectric focusing of tryptic peptides generated from MHC-B phosphorylated with cdc2 kinase revealed one major phosphopeptide that was purified by reverse-phase high performance liquid chromatography and sequenced .","gene":["cdc2 kinase","MHC-B"],"gene_indices_start":[56,82],"gene_indices_end":[61,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4038,"text":"Such an interaction could be detected using a GST-POU fusion protein bound to glutathione-agarose beads .","gene":["GST-POU fusion protein"],"gene_indices_start":[46],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4039,"text":"Molecular cloning of mouse thioredoxin reductases .","gene":["mouse thioredoxin reductases"],"gene_indices_start":[21],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4040,"text":"Factors that showed significant correlation to elevated CIC's in the highly elevated portion of our CIC population were poor NIH score , increased patient age , low peak expiratory flow rate , and elevated total serum IgG .","gene":["serum IgG"],"gene_indices_start":[212],"gene_indices_end":[221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4043,"text":"Thus , the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer .","gene":["pepsin"],"gene_indices_start":[25],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4045,"text":"These cell lines displayed methylation of the CpG island surrounding the first exon of p16INK4A and expressed abundant levels of a nontranslated mRNA containing an alternative first exon ( E1 beta ) , as did all other cell lines in which the p16INK4A locus was not deleted .","gene":["p16INK4A locus","p16INK4A","E1 beta"],"gene_indices_start":[87,189,242],"gene_indices_end":[95,196,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4046,"text":"In reconstitution experiments , we first showed that expression in the RAW 264 . 7 cell line of C-terminal Src kinase ( Csk ) inhibited and that of a membrane-anchored , gain-of-function Csk abolished the Fc gamma R-mediated signaling that leads to phagocytosis in a kinase-dependent manner .","gene":["Csk","Csk","C-terminal Src kinase"],"gene_indices_start":[96,120,187],"gene_indices_end":[117,123,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4047,"text":"These mutants were tested for ability to bind each of the Site II cognate proteins , and subsequently evaluated for ability to confer H4 transcriptional activity using chimeric H4 promoter \/ CAT fusion constructs in different cell types .","gene":["H4","Site II cognate proteins","H4","CAT"],"gene_indices_start":[58,134,177,191],"gene_indices_end":[82,136,179,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4049,"text":"On the other hand , neither phosphate buffered saline injection into the ES nor primary KLH challenges of the ES were capable of elevating the threshold level and changing the latency .","gene":["KLH"],"gene_indices_start":[88],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4051,"text":"Thus , depending on their location , psoralen cross-links affected different steps in the initiation process .","gene":["psoralen"],"gene_indices_start":[37],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4055,"text":"A decrease in insulin-induced receptor kinase activity was observed for solubilized chimeric receptors .","gene":["receptor kinase"],"gene_indices_start":[30],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4056,"text":"BYV , citrus tristeza virus ( CTV ) , beet yellow stunt virus ( BYSV ) and carnation necrotic fleck virus templates produced 1 kb amplification products , which were shown by sequencing to represent fragments of the respective HSP70 genes .","gene":["HSP70 genes"],"gene_indices_start":[227],"gene_indices_end":[238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4057,"text":"At the same time , the results indicate that p53 plays a defensive role against HBV by transcriptionally repressing the HBV core promoter through liver-specific enhancer II and HBx is required to counteract this inhibitory function of p53 .","gene":["p53","liver-specific enhancer II","HBx","HBV core promoter","p53"],"gene_indices_start":[45,120,146,177,235],"gene_indices_end":[48,137,172,180,238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4060,"text":"Our results indicate that V3 peptides from all major clades of HIV-1 carried by HIV-2 gag can be used as a potential HIV \/ AIDS vaccine .","gene":["HIV-2 gag","V3"],"gene_indices_start":[26,80],"gene_indices_end":[28,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4062,"text":"Thrombophlebitis and pulmonary embolism in congenital factor XII deficiency .","gene":["factor XII"],"gene_indices_start":[54],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4065,"text":"In contrast , the CRE of the human c-fos promoter located at -60 was weakly induced by cAMP and E1a in both HeLa and PC12 cells .","gene":["human c-fos promoter","CRE","E1a"],"gene_indices_start":[18,29,96],"gene_indices_end":[21,49,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4066,"text":"The RAD6 \/ UBC2 gene from Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme involved in DNA repair , induced mutagenesis , and sporulation .","gene":["ubiquitin-conjugating enzyme","RAD6 \/ UBC2 gene"],"gene_indices_start":[4,61],"gene_indices_end":[20,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4067,"text":"Deletion of a 53-bp early promoter region containing the transcription start site and a putative TATA box completely abolishes the ability of upstream elements to drive transcription of the luciferase cDNA .","gene":["luciferase cDNA"],"gene_indices_start":[190],"gene_indices_end":[205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4070,"text":"Insulin stimulation promoted the association of mIRS3 with p85 , SHP2 , Nck , and Shc .","gene":["Insulin","p85","Shc","Nck","mIRS3","SHP2"],"gene_indices_start":[0,48,59,65,72,82],"gene_indices_end":[7,53,62,69,75,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4072,"text":"In particular , 71 and 69% amino acid sequence similarities were identified with hsp70 of Escherichia coli and Bacillus megaterium , respectively .","gene":["hsp70 of Escherichia coli and Bacillus megaterium"],"gene_indices_start":[81],"gene_indices_end":[130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4074,"text":"Increased erythropoietin synthesis in patients with COLD or left heart failure is related to alterations in renal haemodynamics .","gene":["erythropoietin"],"gene_indices_start":[10],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4075,"text":"Unlike ARF , the ARP immunoreactivity was detected in plasma membranes but not in cytosol of fractionated 3T3-L1 cells .","gene":["ARP","ARF"],"gene_indices_start":[7,17],"gene_indices_end":[10,20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4076,"text":"The deduced amino acid sequence of destrin is 165 residues long and is very similar ( 71% identical ) to that of cofilin , a widely distributed , pH-sensitive actin-modulating protein .","gene":["destrin","cofilin"],"gene_indices_start":[35,113],"gene_indices_end":[42,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4079,"text":"Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) transcription .","gene":["PEA3 binding sites","murine tissue inhibitor of metalloproteinases-1","AP1","TIMP-1"],"gene_indices_start":[15,23,63,113],"gene_indices_end":[18,41,110,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4080,"text":"Alternative processing of the tryptophanyl-tRNA synthetase mRNA from interferon-treated human cells .","gene":["tryptophanyl-tRNA synthetase mRNA"],"gene_indices_start":[30],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4081,"text":"Oligonucleotide competitors were used to evaluate the accessibility of the TATA-binding site in TIF-IB , TFIID , and TFIIIB .","gene":["TFIIIB","TFIID","TIF-IB"],"gene_indices_start":[96,105,117],"gene_indices_end":[102,110,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4085,"text":"Human LAF-4 readily hybridized with genes in mouse and chicken , thus showing that this gene family has been highly conserved during vertebrate evolution .","gene":["Human LAF-4"],"gene_indices_start":[0],"gene_indices_end":[11],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4086,"text":"Northern analysis , to search for a pcbAB transcript , showed no distinct transcript and indicated severely degraded mRNA .","gene":["pcbAB transcript"],"gene_indices_start":[36],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4087,"text":"RESULTS : In an 18 moth period and out of a total of 284 positive blood cultures ( 154 significant isolations ) 14 episodes of bacteremia by M . tuberculosis were studied in 12 prison patients coinfected by the human immunodeficiency virus with associated severe immunosuppression ( mean of CD4 = 0 . 068 x 10 ( 9 ) \/ l ) .","gene":["CD4"],"gene_indices_start":[291],"gene_indices_end":[294],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4089,"text":"The genes encoding the transcription factor yTAFII60 , the G4p1 protein and a putative glucose transporter are contained in a 12 . 3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII .","gene":["glucose transporter","transcription factor yTAFII60","G4p1 protein"],"gene_indices_start":[23,59,87],"gene_indices_end":[52,71,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4091,"text":"In the presence of the in vivo reducing system ( thioredoxin , thioredoxin reductase , and NADPH ) , however , each of these mutants catalyzed the formation of only 0 . 6-0 . 8 dCTPs per mole of enzyme .","gene":["thioredoxin","thioredoxin reductase"],"gene_indices_start":[49,63],"gene_indices_end":[60,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4093,"text":"Functional and regulatory analysis of the two copies of the fixNOQP operon of Rhizobium leguminosarum strain VF39 .","gene":["fixNOQP operon"],"gene_indices_start":[60],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4094,"text":"The 9 ; 22 chromosomal translocation characteristic of CML results in a fused bcr \/ abl gene and an abnormal fusion protein , p210bcr \/ abl .","gene":["fused bcr \/ abl gene","p210bcr \/ abl"],"gene_indices_start":[72,126],"gene_indices_end":[92,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4097,"text":"Subcellular localizations of the wild-type CBFbeta and the CBFbeta-SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild-type or fusion protein .","gene":["CBFbeta-SMMHC fusion protein","wild-type CBFbeta"],"gene_indices_start":[33,59],"gene_indices_end":[50,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4098,"text":"In conclusion , IgM class CIC is the predominant CIC in acute hepatitis A and correlated with disease activity .","gene":["IgM"],"gene_indices_start":[16],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4100,"text":"We further demonstrate that the Stress-Activated-Protein-Kinase ( SAPK ) target sites of ATF2 , Thr69 and Thr71 are not required for the formation of the p300 \/ CBP-ATF2 multiprotein complex .","gene":["Stress-Activated-Protein-Kinase","SAPK","p300 \/ CBP-ATF2","ATF2"],"gene_indices_start":[32,66,89,154],"gene_indices_end":[63,70,93,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4103,"text":"Oncogenic capacity of the E2F1 gene .","gene":["E2F1 gene"],"gene_indices_start":[26],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4104,"text":"Thus , Sir proteins from K . lactis have roles in both silencing and telomere length maintenance , reflecting conserved functional themes .","gene":["Sir proteins"],"gene_indices_start":[7],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4105,"text":"The p55 mRNA is undetectable in non-EBV-infected B- and T-cell lines or in a myelomonocytic cell line ( U937 ) .","gene":["p55 mRNA"],"gene_indices_start":[4],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4106,"text":"Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases .","gene":["histone acetylases","deacetylases"],"gene_indices_start":[88,111],"gene_indices_end":[106,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4109,"text":"SRF-deficient embryos ( Srf - \/ - ) have a severe gastrulation defect and do not develop to term .","gene":["Srf"],"gene_indices_start":[24],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4110,"text":"Four full-thickness skin incisions were made in the back of 10 female pigs that treated twice a day for 14 days with 2 ml of epidermal growth factor ( 300 ng \/ ml ) or 2 ml of Ringer's lactate solution in a single-blind , randomized fashion .","gene":["epidermal growth factor"],"gene_indices_start":[125],"gene_indices_end":[148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4112,"text":"In mammalian tissue culture cells , overexpression of any of the four mouse deltex homologs suppressed the transcriptional activity of E47 , a basic helix-loop-helix ( bHLH ) protein , in a manner similar to suppression by an activated form of human Notch1 or human DTX1 .","gene":["E47","human Notch1","basic helix-loop-helix ( bHLH ) protein","human DTX1"],"gene_indices_start":[135,143,244,260],"gene_indices_end":[138,182,256,270],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4117,"text":"Inhibition of the Raf-1 target ERK kinase ( MEK ) either attenuated or abolished Rp-cAMPS- and PKI-induced ERK activation , caldesmon phosphorylation , and stress fiber formation .","gene":["ERK","Raf-1 target","MEK","caldesmon","ERK kinase"],"gene_indices_start":[18,31,44,107,124],"gene_indices_end":[30,41,47,110,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4118,"text":"METHODS : T2*-weighted , three-dimensional gradient-echo images were acquired by exploiting the magnetic susceptibility difference between oxygenated and deoxygenated hemoglobin in the vasculature and microvasculature .","gene":["hemoglobin"],"gene_indices_start":[167],"gene_indices_end":[177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4120,"text":"The rci gene was fused with lacZ and its gene product was identified by Western blot analysis .","gene":["rci gene","lacZ"],"gene_indices_start":[4,28],"gene_indices_end":[12,32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4121,"text":"Thus , multiple myogenic factors that vary qualitatively and quantitatively may be responsible for the different and complex modulatory programs of actin gene expression observed during in vivo muscle differentiation .","gene":["actin gene"],"gene_indices_start":[148],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4123,"text":"Many cells were negative for endothelial-cell markers , and they reacted with a monoclonal antibody against muscle actin .","gene":["actin"],"gene_indices_start":[115],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4125,"text":"Of these sites , PEA3 and STAT contributed specifically to induction by v-src , whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate ( PMA ) .","gene":["STAT","v-src","PEA3"],"gene_indices_start":[17,26,72],"gene_indices_end":[21,30,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4129,"text":"We therefore applied a radiolabelled serumalbumin method to determine blood volume after haemodilution with crosslinked or conjugated haemoglobin , in comparison with a reference solution of hydroxyethyl starch ( HES ) .","gene":["haemoglobin"],"gene_indices_start":[134],"gene_indices_end":[145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4133,"text":"Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product .","gene":["alpha gene product","herpes simplex virus beta and gamma genes"],"gene_indices_start":[14,112],"gene_indices_end":[55,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4136,"text":"The human ABCG1 gene encodes a member of the ATP-binding cassette ( ABC ) superfamily of transporter proteins and is highly induced when macrophages are incubated with oxysterols .","gene":["transporter proteins","human ABCG1 gene","ABC","ATP-binding cassette"],"gene_indices_start":[4,45,68,89],"gene_indices_end":[20,65,71,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4137,"text":"Yap1p is constitutively nuclear in a crm1 mutant , and Crm1p binds to a nuclear export sequence ( NES ) -like sequence in Yap1p in the presence of RanGTP .","gene":["crm1 mutant","Yap1p","Yap1p","RanGTP","Crm1p"],"gene_indices_start":[0,37,55,122,147],"gene_indices_end":[5,48,60,127,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4140,"text":"However , using ATL-16T nuclear extract , we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the -70 GATA site .","gene":["GATA-4","-70 GATA site","GATA-binding protein"],"gene_indices_start":[63,82,152],"gene_indices_end":[69,102,165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4143,"text":"Thus , we have produced lipoyl domain constructs that can be employed in sorting the specific roles of E2L1 and E2L2 in facilitating catalytic and regulatory processes .","gene":["E2L1","E2L2"],"gene_indices_start":[103,112],"gene_indices_end":[107,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4144,"text":"Transfecting the cloned bovine PBR \/ IBP cDNA into COS-7 cells resulted in an 11-fold increase in the density of high affinity [ 3H ] PK 11195 binding sites which had only low affinity for Ro5-4864 .","gene":["PBR","IBP"],"gene_indices_start":[31,37],"gene_indices_end":[34,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4145,"text":"Digestion of NF-IL6 with endoprotease Asp-N produced a domain smaller than the TCD ( NF-IL6 bZIP domains ( NFBD ) ( 272-345 ) ) , a domain identified either in the absence or the presence of DNA .","gene":["NFBD","TCD","NF-IL6","endoprotease Asp-N","NF-IL6 bZIP domains"],"gene_indices_start":[13,25,79,85,107],"gene_indices_end":[19,43,82,104,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4149,"text":"These results demonstrate that although PI2 and PI3 viruses belong to the same parainfluenza virus genus , these viruses show marked differences with respect to functional requirements for the cytoplasmic tail of the F glycoprotein .","gene":["F glycoprotein"],"gene_indices_start":[217],"gene_indices_end":[231],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4150,"text":"The human cytomegalovirus ( HCMV ) major immediate-early protein IE2 is a nuclear phosphoprotein that is believed to be a key regulator in both lytic and latent infections .","gene":["nuclear phosphoprotein","human cytomegalovirus ( HCMV ) major immediate-early protein IE2"],"gene_indices_start":[4,74],"gene_indices_end":[68,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4154,"text":"A mutational analysis has resolved a region of seven amino acids ( amino acids 26-32 ) in the N-terminus of Bob1 that are important for contacting the DNA binding POU domain of Oct-1 or Oct-2 .","gene":["POU domain","Oct-2","Oct-1","Bob1"],"gene_indices_start":[108,163,177,186],"gene_indices_end":[112,173,182,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4156,"text":"These findings show that EBP50 is a physiologically relevant ezrin binding protein .","gene":["EBP50","ezrin binding protein"],"gene_indices_start":[25,61],"gene_indices_end":[30,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4158,"text":"Because endogenous HSF DNA-binding activity is low and anti-hHSF1 antibody does not recognize Xenopus HSF , we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state .","gene":["hHSF1","HSF","Xenopus HSF","anti-hHSF1 antibody"],"gene_indices_start":[19,55,94,155],"gene_indices_end":[22,74,105,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4161,"text":"We discuss these results with respect to the transcriptional induction of the HNF-3 alpha gene in respiratory epithelium during embryogenesis .","gene":["HNF-3 alpha gene"],"gene_indices_start":[78],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4162,"text":"We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron , zinc , circulating leukocyte counts , and plasma interleukin 1 ( IL-1 ) activity .","gene":["interleukin 1","IL-1"],"gene_indices_start":[201,217],"gene_indices_end":[214,221],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4164,"text":"Three cysteine and four tryptophan residues , previously identified as conserved amongst nitrous-oxide reductases , are found in the Paracoccus enzyme .","gene":["nitrous-oxide reductases"],"gene_indices_start":[89],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4165,"text":"Animal age and sex had no significant effects on CSF composition , but serum IgG concentration increased with age .","gene":["IgG"],"gene_indices_start":[77],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4166,"text":"These studies point to the involvement of the MAP kinase pathway in the activation of monocytic cells during transmigration to inflammatory sites .","gene":["MAP kinase"],"gene_indices_start":[46],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4167,"text":"This gene encodes a putative transcription factor with regions of homology to several other proteins including the zinc fingers and other domains of the Drosophila trithorax gene product , and the \"AT-hook\" DNA-binding motif of high mobility group proteins .","gene":["\"AT-hook\" DNA-binding motif","high mobility group proteins","Drosophila trithorax gene product"],"gene_indices_start":[153,197,228],"gene_indices_end":[186,224,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4172,"text":"The 11 ; 22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminal-encoding portion of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI1 gene .","gene":["FLI1 gene","EWS gene"],"gene_indices_start":[192,260],"gene_indices_end":[200,269],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4174,"text":"We randomly assigned 1 , 219 subjects to receive either the standard three-times-weekly ( TIW ) interferon alfa-2b dose ( 3 MIU ) or the once-weekly ( QW ) peginterferon alfa-2b ( 0 . 5 , 1 . 0 , or 1 . 5 microg \/ kg ) .","gene":["interferon alfa-2b"],"gene_indices_start":[96],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4175,"text":"We show that CBF-A and CBF-C interact with each other to form a CBF-A-CBF-C complex and that CBF-B does not interact with CBF-A or CBF-C individually but that it associates with the CBF-A-CBF-C complex .","gene":["CBF-A-CBF-C complex","CBF-C","CBF-C","CBF-A","CBF-A-CBF-C complex","CBF-B","CBF-A"],"gene_indices_start":[13,23,64,93,122,131,182],"gene_indices_end":[18,28,83,98,127,136,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4176,"text":"Protein S levels were virtually undetectable at the time of admission and failed to respond to infusions of fresh frozen plasma , despite correction of other procoagulant and anticoagulant factors .","gene":["Protein S"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4178,"text":"While Pt ; cycH ; 1 and Os ; cycH ; 1 were expressed in all tissues examined , the transcripts accumulated abundantly in dividing cells .","gene":["Pt ; cycH ; 1","Os ; cycH ; 1"],"gene_indices_start":[6,24],"gene_indices_end":[19,37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4185,"text":"The specific interaction between a defined structural element of the human immunodeficiency virus mRNA ( RRE , the Rev response element ) and the virus-encoded protein Rev has been implicated in the regulation of the export of unspliced or singly spliced mRNA from the nucleus to the cytoplasm .","gene":["RRE","virus-encoded protein Rev","Rev response element"],"gene_indices_start":[105,115,146],"gene_indices_end":[108,135,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4188,"text":"In conclusion , these observations demonstrated that stratification of acute MI patients by plasma ANF level is a useful non-invasive method for predicting prognosis and for identifying individuals at high risk of cardiac death .","gene":["ANF"],"gene_indices_start":[99],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4189,"text":"Heat-inducible CAT activity was detectable when additional sequences from the native promoter containing three CCAAT boxes and a single HSE were present in the constructions .","gene":["CAT","HSE"],"gene_indices_start":[15,136],"gene_indices_end":[18,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4190,"text":"Characterization of a Xenopus laevis CXC chemokine receptor 4 : implications for hematopoietic cell development in the vertebrate embryo .","gene":["Xenopus laevis CXC chemokine receptor 4"],"gene_indices_start":[22],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4192,"text":"Moreover , the hypoxia-induced expression of the endogenous Epo gene was significantly inhibited in Hep3B cells stably transfected with HNF-4 delta C .","gene":["Epo gene","HNF-4 delta C"],"gene_indices_start":[60,136],"gene_indices_end":[68,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4194,"text":"Two XPG regions with putative NLS [ amino acid ( AA ) coordinates : NLS-B ( AA 1057-1074 ) and NLS-C ( AA 1171-1185 ) ] were each shown to independently localize the beta-gal extensively ( > 80% ) to the nucleus of HeLa cells .","gene":["beta-gal","XPG regions"],"gene_indices_start":[4,166],"gene_indices_end":[15,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4195,"text":"Although metabolized by the cytochrome P-450 ( CYP ) system , venlafaxine inhibits CYP 2D6 and 3A4 to a far lesser extent than do the SSRIs .","gene":["CYP 2D6 and 3A4","CYP","cytochrome P-450"],"gene_indices_start":[28,47,83],"gene_indices_end":[44,50,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4196,"text":"Signaling by tyrosine kinases involves direct associations between proteins with Src homology 2 ( SH2 ) domains and sites of tyrosine phosphorylation .","gene":["SH2","Src homology 2","tyrosine kinases"],"gene_indices_start":[13,81,98],"gene_indices_end":[29,95,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4197,"text":"In addition , and in support of a mediating role of STATs in the activation of the p21 promoter , overexpression of Stat3 potentiated the cytokine effect on the p21 promoter ; whereas a dominant negative Stat3 , or a mutation of the STAT response element on the promoter , significantly reduced the cytokine effect .","gene":["dominant negative Stat3","p21 promoter","STATs","Stat3","p21 promoter","STAT response element"],"gene_indices_start":[52,83,116,161,186,233],"gene_indices_end":[57,95,121,173,209,254],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4199,"text":"Testing for serum IgM binding to GM1 ganglioside in clinical practice .","gene":["serum IgM"],"gene_indices_start":[12],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4200,"text":"Using GST-PKR fusion chromatography , direct physical interaction between the mouse and human PKR homologs was established .","gene":["GST-PKR fusion","human PKR homologs"],"gene_indices_start":[6,88],"gene_indices_end":[20,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4202,"text":"Sp1's role in transactivation of the pgp2 \/ mdr1b promoter was tested in Drosophila Schneider cells .","gene":["pgp2 \/ mdr1b promoter"],"gene_indices_start":[37],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4204,"text":"Studies were performed on several superficial veins from the rabbit face to examine the relationship between beta adrenoceptor subtype distribution , intrinsic myogenic tone and sympathetic nerve innervation .","gene":["beta adrenoceptor subtype"],"gene_indices_start":[109],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4206,"text":"In this paper , we have analyzed the structure of human gene for Gx alpha , which spans more than 60 kilobases .","gene":["Gx alpha"],"gene_indices_start":[65],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4208,"text":"Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation .","gene":["CREB","protein kinase","Nuclear protein phosphatase 2A","CREB"],"gene_indices_start":[0,48,80,99],"gene_indices_end":[30,62,84,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4209,"text":"Antileukoproteinase ( ALP ) is a low mol wt mucosal secretory protein which , in human tissues , inhibits the activities of the neutral serine lysosomal proteinases elastase and cathepsin-G .","gene":["ALP","elastase","cathepsin-G","Antileukoproteinase","serine lysosomal proteinases"],"gene_indices_start":[0,22,136,165,178],"gene_indices_end":[19,25,164,173,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4212,"text":"There was however , no significant difference in the prevalence of chronic respiratory symptoms between animal food workers with positive and negative skin tests to house dust or to fish flour or among those with increased or normal IgE ( except for dyspnea ) .","gene":["IgE"],"gene_indices_start":[233],"gene_indices_end":[236],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4220,"text":"As with the murine and human mb-1 genes , the 5' region of the bovine mb-1 gene lacked a TATA box .","gene":["murine and human mb-1 genes","bovine mb-1 gene"],"gene_indices_start":[12,63],"gene_indices_end":[39,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4221,"text":"Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-terminal regulatory domain of SOS2 are functionally essential .","gene":["sos2 mutant alleles","SOS2"],"gene_indices_start":[21,130],"gene_indices_end":[40,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4222,"text":"Furthermore , analysis of the E2 proteins present in various cell lines harboring specific BPV-1 mutants , including the 2558 acceptor mutant , proves that alternate modes of E2 expression exist .","gene":["E2","2558 acceptor mutant","E2 proteins"],"gene_indices_start":[30,121,175],"gene_indices_end":[41,141,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4224,"text":"Cyclins are one of the pivotal determinants regulating cell cycle progression .","gene":["Cyclins"],"gene_indices_start":[0],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4228,"text":"In all sessions under IFN , the latency of the P100 component of the VEP was shortened as compared to baseline conditions .","gene":["IFN"],"gene_indices_start":[22],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4231,"text":"In human proliferative cells , the NADP-dependent ME activity is poorly expressed and barely inducible by thyroid hormones .","gene":["ME"],"gene_indices_start":[50],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4232,"text":"The delta srb10 mutation also influenced on the transcript levels of meiosis-inducing genes called IME1 and IME2 : the mutation elevated the transcript level of IME1 but reduced that of IME2 , resulting in partial defects in premeiotic DNA synthesis and meiosis .","gene":["IME2","IME1","delta srb10 mutation","IME1","IME2"],"gene_indices_start":[4,99,108,161,186],"gene_indices_end":[24,103,112,165,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4233,"text":"After screening the Berkeley Drosophila Genome Project database with sequences from a recently characterized Leu-rich repeats-containing G protein-coupled receptor ( LGR ) from Drosophila ( DLGR-1 ) , we identified a second gene for a different LGR ( DLGR-2 ) and cloned its cDNA .","gene":["LGR","LGR","DLGR-2","Leu-rich repeats-containing G protein-coupled receptor","DLGR-1"],"gene_indices_start":[109,166,190,245,251],"gene_indices_end":[163,169,196,248,257],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4235,"text":"The telomerase RNA-protein complex responsible for maintenance of telomeric DNA at chromosome ends , is usually inactive in most primary somatic human cells , but is specifically activated with in vitro immortalization and during tumorigenesis .","gene":["telomerase RNA-protein complex"],"gene_indices_start":[4],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4237,"text":"Interferon type I in protective body reactions in an experimental Klebsiella infection .","gene":["Interferon type I"],"gene_indices_start":[0],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4238,"text":"In addition , the consensus amino acid motif for serine threonine receptor kinases was also present .","gene":["serine threonine receptor kinases"],"gene_indices_start":[49],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4239,"text":"However , despite its relationship to the TR , Rev-Erb bound poorly to TR binding sites .","gene":["TR","Rev-Erb","TR binding sites"],"gene_indices_start":[42,47,71],"gene_indices_end":[44,54,87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4240,"text":"These data suggest that the G-protein gene family may be distributed over at least two human chromosomes .","gene":["G-protein gene family"],"gene_indices_start":[28],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4241,"text":"Radioimmunoassay of serum creatine kinase B isoenzyme in the diagnosis of acute myocardial infarction .","gene":["creatine kinase B isoenzyme"],"gene_indices_start":[26],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4242,"text":"Two potential regulatory sequences for DNA binding proteins were found in the non-coding 5' region : a HAP2 \/ HAP3 consensus recognition sequence at nucleotide-154 and a BAF1 consensus recognition sequence at nucleotide-136 .","gene":["BAF1 consensus recognition sequence","HAP2 \/ HAP3 consensus recognition sequence"],"gene_indices_start":[103,170],"gene_indices_end":[145,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4243,"text":"Transfection experiments using preformed triplexes with a reporter plasmid containing the collagen promoter sequence showed significant inhibition of transcription when compared with a control phosphorothioate ODN .","gene":["collagen promoter sequence"],"gene_indices_start":[90],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4244,"text":"The nucleotide sequences at the 5' and 3' ends of these introns are characteristic of spliced transcripts from eukaryotic protein-encoding genes , with one significant difference ; i . e . , the 5' end of the LAT intron is GC instead of the consensus sequence GT .","gene":["LAT intron"],"gene_indices_start":[209],"gene_indices_end":[219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4245,"text":"Human T-cell leukemia virus type I Tax activation of NF-kappa B \/ Rel involves phosphorylation and degradation of I kappa B alpha and RelA ( p65 ) -mediated induction of the c-rel gene .","gene":["Tax","p65","I kappa B alpha","NF-kappa B \/ Rel","RelA","c-rel gene"],"gene_indices_start":[35,53,114,134,141,174],"gene_indices_end":[38,69,129,138,144,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4248,"text":"A synergistic effect on HCK promoter activity was observed at high concentrations of Sp1 .","gene":["Sp1","HCK promoter"],"gene_indices_start":[24,85],"gene_indices_end":[36,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4249,"text":"Further characterization of these putative Hoxa-1 target genes will aid in delineating the functions of the Hoxa-1 protein in the differentiation processes which occur during embryogenesis .","gene":["Hoxa-1 protein","Hoxa-1 target genes"],"gene_indices_start":[43,108],"gene_indices_end":[62,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4250,"text":"The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D .","gene":["protein synthesis initiation factor eIF-4D","ANB1 locus"],"gene_indices_start":[4,55],"gene_indices_end":[14,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4252,"text":"Although the risk of malformation in children born after ICSI is not increased there is an increased risk to transmit genetic abnormalities in case of NOA ( such as the rate of sex chromosome , or microdeletions of the Y chromosome ) and in case of congenital OA ( mutations of the cystic fibrosis gene ) .","gene":["cystic fibrosis gene"],"gene_indices_start":[282],"gene_indices_end":[302],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4254,"text":"Promoter activities were estimated using beta-glucuronidase and neomycin phosphotransferase II reporter gene systems .","gene":["beta-glucuronidase","neomycin phosphotransferase II reporter gene systems"],"gene_indices_start":[41,64],"gene_indices_end":[59,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4256,"text":"In vivo association between Shb-SH3 domain proteins v-Src and Eps8 was detected by coimmunoprecipitation .","gene":["Shb-SH3 domain","v-Src","Eps8"],"gene_indices_start":[28,52,62],"gene_indices_end":[42,57,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4257,"text":"The first gene codes for a protein containing 11 cystein residues in an arrangement typical for Fe \/ S proteins .","gene":["Fe \/ S proteins"],"gene_indices_start":[96],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4258,"text":"In 7 of 9 cases , the enhancer is fused to the c-myc bearing sequences of chromosome 8 .","gene":["c-myc bearing sequences"],"gene_indices_start":[47],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4262,"text":"Each immunoprecipitate contained a complex of N1 ( deltaEC ) and CBF1 .","gene":["N1 ( deltaEC )","CBF1"],"gene_indices_start":[46,65],"gene_indices_end":[60,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4264,"text":"The hBRAG gene was localized to the long arm of chromosome 10 ( 10q26 ) .","gene":["hBRAG gene"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4265,"text":"Dopamine receptor blockade and the neuroleptics , a crystallographic study .","gene":["Dopamine receptor"],"gene_indices_start":[0],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4272,"text":"This phosphorylation can be catalyzed by a break-ended double-stranded DNA-activated protein kinase activity from the sea urchin nucleus in vitro .","gene":["protein kinase"],"gene_indices_start":[85],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4273,"text":"In addition , we also show that cdk7 may phosphorylate the carboxy-terminal domain ( CTD ) of RNA pol II in the absence of promoter opening .","gene":["RNA pol II","cdk7"],"gene_indices_start":[32,94],"gene_indices_end":[36,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4279,"text":"Human rIL-3 expressed in COS7 cells has multipotential CSF activity in semisolid cultures of bone marrow cells , and selectively induced the proliferation of My-10+ marrow or cord blood cells in liquid cultures .","gene":["CSF","Human rIL-3"],"gene_indices_start":[0,55],"gene_indices_end":[11,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4280,"text":"EBER1 mRNA , a consistent marker of viral latency , was positive in all PEL cases , although at lower levels than in the non-PEL controls due to EBER1 expression by only a variable subset of lymphoma cells .","gene":["EBER1","EBER1 mRNA"],"gene_indices_start":[0,145],"gene_indices_end":[10,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4281,"text":"We used two approaches to ascertain whether CDP \/ cut serves as a repressor of gp91-phox gene expression .","gene":["CDP \/ cut","gp91-phox gene"],"gene_indices_start":[44,79],"gene_indices_end":[53,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4282,"text":"Interestingly , one IRF binding site was found within the IRF-2 promoter , and expression of the IRF-2 gene was affected by both transient and stable IRF-1 expression .","gene":["IRF-2 gene","IRF binding site","IRF-1","IRF-2 promoter"],"gene_indices_start":[20,58,97,150],"gene_indices_end":[36,72,107,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4286,"text":"Furthermore , both rhHR23 proteins function in a defined NER system reconstituted with purified proteins , indicating direct involvement of hHR23 proteins in the DNA repair reaction via interaction with XPC .","gene":["rhHR23 proteins","XPC","hHR23 proteins"],"gene_indices_start":[19,140,203],"gene_indices_end":[34,154,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4292,"text":"DNA blot hybridization suggests that the rat genome may contain more than one gene encoding PtdIns transfer protein .","gene":["PtdIns transfer protein"],"gene_indices_start":[92],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4293,"text":"The deduced protein sequence was 88% homologous to that of hNUC I , isolated from human osteosarcoma cells .","gene":["hNUC I"],"gene_indices_start":[59],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4295,"text":"Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB , independently of CREB phosphorylation .","gene":["CREB","RNA polymerase II complex","CREB"],"gene_indices_start":[18,97,121],"gene_indices_end":[43,101,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4298,"text":"Treatment of keratinocytes expressing a normal epidermal growth factor receptor ( EGFR ) with TGFalpha or epidermal growth factor for 5 min induced PKCdelta tyrosine phosphorylation .","gene":["epidermal growth factor","EGFR","TGFalpha","epidermal growth factor receptor","PKCdelta"],"gene_indices_start":[47,82,94,106,148],"gene_indices_end":[79,86,102,129,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4303,"text":"As an oral , nontoxic compound with a mechanism of action distinct from that of ABL tyrosine kinase inhibition , FTI SCH66336 shows promise for the treatment of BCR \/ ABL-induced leukemia .","gene":["ABL tyrosine kinase"],"gene_indices_start":[80],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4305,"text":"Genomic locus of chCTCF contains a GC-rich untranslated exon separated from seven coding exons by a long intron .","gene":["chCTCF"],"gene_indices_start":[17],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4308,"text":"Deletion and site-directed mutagenesis localized a novel SF-1 regulatory element ( TCA GGGCCA ; -137 to -129 ) adjacent to a variant cAMP-response element ( CRE ; -120 to -114 ) .","gene":["CRE","cAMP-response element","TCA GGGCCA","SF-1 regulatory element"],"gene_indices_start":[57,83,133,157],"gene_indices_end":[80,93,154,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4310,"text":"Regional insertional mutagenesis of specific genes on the CIC5F11 \/ CIC2B9 locus of Arabidopsis thaliana chromosome 5 using the Ac \/ Ds transposon in combination with the cDNA scanning method .","gene":["Ac \/ Ds transposon","CIC5F11 \/ CIC2B9 locus"],"gene_indices_start":[58,128],"gene_indices_end":[80,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4311,"text":"Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter .","gene":["complement C3"],"gene_indices_start":[39],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4312,"text":"Three of the short ORFs in the central region of BIV have been identified by location and structural similarity to the nonstructural \/ regulatory genes ( vif , tat , and rev ) of other lentiviruses ; we also discovered two unique ORFs , termed W and Y , which may serve as exons for novel genes .","gene":["W","rev","Y","vif","tat"],"gene_indices_start":[154,160,170,244,250],"gene_indices_end":[157,163,173,245,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4316,"text":"Serum PTH tended to increase in the WL group but not in the WM group ( P < 0 . 06 ) .","gene":["Serum PTH"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4317,"text":"When multiple copies of the IL-1 beta NF-kappa B site were linked to an enhancerless simian virus 40 promoter , this element was able to mediate phorbol ester- or lipopolysaccharide-inducible gene expression .","gene":["IL-1 beta","NF-kappa B site"],"gene_indices_start":[28,38],"gene_indices_end":[37,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4318,"text":"The ability of BCL-6 to function as a transcriptional repressor may contribute to its ability to transform B lymphocytes in diffuse large cell lymphoma .","gene":["BCL-6"],"gene_indices_start":[15],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4322,"text":"Diagnostic value of serum myoglobin in cases of neuromuscular disease .","gene":["serum myoglobin"],"gene_indices_start":[20],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4323,"text":"We found the following : Specific mutations affected the precise carbohydrate structure and folding of the HA trimer .","gene":["HA trimer"],"gene_indices_start":[107],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4330,"text":"Transient transfection experiments revealed that Pax-8 isoforms a and b , but not c and d , strongly stimulate transcription from a promoter containing six copies of a paired-domain recognition sequence .","gene":["paired-domain recognition sequence","Pax-8 isoforms a and b"],"gene_indices_start":[49,168],"gene_indices_end":[71,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4332,"text":"In DNase I footprinting protection analysis , both SFRE and ERE regions were protected by glutathione S-transferase-ERRalpha1 fusion protein .","gene":["glutathione S-transferase-ERRalpha1 fusion protein","SFRE","ERE regions","DNase I"],"gene_indices_start":[3,51,60,90],"gene_indices_end":[10,55,71,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4336,"text":"Transcription from adenovirus E2-early promoter is controlled by a unique array of four cis-acting elements which include an atypical TBP site , two E2F sites present in an inverted orientation relative to each other , and an ATF site .","gene":["E2F sites","ATF site","adenovirus E2-early promoter","TBP site"],"gene_indices_start":[19,134,149,226],"gene_indices_end":[47,142,158,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4339,"text":"More generally , Ets1 and Ets2 could regulate transcription of cellular genes .","gene":["Ets2","Ets1"],"gene_indices_start":[17,26],"gene_indices_end":[21,30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4340,"text":"The cdr1 sequence includes an additional 237 amino acids of the contiguous fragment and encodes a product of predicted Mr 67 , 000 .","gene":["cdr1 sequence"],"gene_indices_start":[4],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4343,"text":"Sequence analysis of these regions showed a CAAT box upstream of exon 1a and high G-C content regions within both P1 and P2 .","gene":["P1","P2"],"gene_indices_start":[114,121],"gene_indices_end":[116,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4345,"text":"This construct , termed pDeltaCREC \/ EBP , binds C \/ EBPalpha and beta but not CREB , yet it confers a nearly complete glucocorticoid response when transiently transfected into H4IIE rat hepatoma cells .","gene":["C \/ EBPalpha and beta","CREB","pDeltaCREC \/ EBP"],"gene_indices_start":[24,49,79],"gene_indices_end":[40,70,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4346,"text":"The region containing both serines is homologous to the N-terminal destruction box of IkappaBalpha , -beta , and -epsilon .","gene":["IkappaBalpha , -beta , and -epsilon"],"gene_indices_start":[86],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4348,"text":"Herein , we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin ( Xtwn ) .","gene":["Xenopus homeobox gene","Xtwn","LEF1","twin","Wnt pathways","HMG box domain","TGFbeta","Smad3"],"gene_indices_start":[22,58,76,90,102,158,180,187],"gene_indices_end":[27,72,80,97,114,179,184,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4353,"text":"The human protein sequence exhibits a putative DNA-binding domain similar to that seen in rat HBP1 and shows homology with the activation and repressor domains previously demonstrated in the rat protein .","gene":["rat HBP1"],"gene_indices_start":[90],"gene_indices_end":[98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4354,"text":"These results demonstrate that EKLF provides a crucial transactivation function for globin expression and further reinforce the idea that EKLF is an important regulator of CACCC element-directed transcription in erythroid cells .","gene":["EKLF","EKLF","globin"],"gene_indices_start":[31,84,138],"gene_indices_end":[35,90,142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4355,"text":"Although the DSK2-1 mutation alters a conserved residue in the Dsk2p ubiquitin-like domain , we detect no differences in Dsk2p or Cdc31p stability .","gene":["ubiquitin-like domain","Dsk2p","Dsk2p","Cdc31p","DSK2-1 mutation"],"gene_indices_start":[13,63,69,121,130],"gene_indices_end":[28,68,90,126,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4356,"text":"Characteristics of lipase activity .","gene":["lipase"],"gene_indices_start":[19],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4357,"text":"The complete cDNA sequence of human betaV spectrin is available from GenBank ( TM ) as accession number .","gene":["human betaV spectrin"],"gene_indices_start":[30],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4360,"text":"In contrast , the neu proto-oncogene did not show kinase activity or transforming properties when expressed at similar levels in NIH 3T3 cells . ( ABSTRACT TRUNCATED AT 250 WORDS )","gene":["neu proto-oncogene"],"gene_indices_start":[18],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4361,"text":"The CVA16 . 4 proteolipid transcript is the most prevalent of the two proteolipid messages in expanding ovules harvested 10 d post-anthesis .","gene":["CVA16 . 4 proteolipid transcript"],"gene_indices_start":[4],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4362,"text":"Furthermore , interactions were identified between endogenous E-cadherin and the chimera containing the E-cadherin extracellular domain and the desmoglein 1 intracellular domain providing in vivo evidence for previously predicted lateral interactions of E-cadherin extracellular domains .","gene":["E-cadherin extracellular domain","E-cadherin extracellular domains","desmoglein 1 intracellular domain","endogenous E-cadherin"],"gene_indices_start":[51,104,144,254],"gene_indices_end":[72,135,177,286],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4363,"text":"No UOxase mRNA was detected in 11 nonhepatic tissues of rat , suggesting tissue specificity of expression of this UOxase gene .","gene":["UOxase mRNA","UOxase gene"],"gene_indices_start":[3,114],"gene_indices_end":[14,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4366,"text":"The CAPLC1 protein also exhibited several unique features , including a novel stretch of 18-19 amino acid residues within the X domain and an unusually long N-terminus which did not contain a recognizable EF-hand Ca ( 2+ ) -binding domain .","gene":["CAPLC1 protein","X domain","EF-hand Ca ( 2+ ) -binding domain"],"gene_indices_start":[4,126,205],"gene_indices_end":[18,134,238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4369,"text":"Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae .","gene":["tRNA nucleotidyltransferase","gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae"],"gene_indices_start":[60,107],"gene_indices_end":[87,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4371,"text":"Finally , we present evidence that fimbrin is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine .","gene":["plastin isoform","fimbrin"],"gene_indices_start":[35,63],"gene_indices_end":[42,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4373,"text":"Growth hormone and insulin-like growth factor I receptors in the temporomandibular joint of the rat .","gene":["insulin-like growth factor I receptors","Growth hormone"],"gene_indices_start":[0,19],"gene_indices_end":[14,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4374,"text":"Adverse foetal outcome in specific IgM positive Chlamydia trachomatis infection in pregnancy .","gene":["IgM"],"gene_indices_start":[35],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4375,"text":"On the basis of size , the CRS sequence to which it binds , and its tentative identification as a zinc finger protein , Adx factor has been identified as a Kruppel-like zinc finger protein ( a mouse ZBP-89 homologue ) .","gene":["mouse ZBP-89 homologue","CRS sequence","Adx factor","zinc finger protein","Kruppel-like zinc finger protein"],"gene_indices_start":[27,98,120,156,193],"gene_indices_end":[39,117,130,188,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4376,"text":"STP1 is an unessential yeast gene involved in the removal of intervening sequences from some , but not all , families of intervening sequence-containing pre-tRNAs .","gene":["STP1"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4378,"text":"Both P5CDh cDNA clones detect a single 3 . 2-kb transcript on Northern blots of multiple human tissues , indicating the long cDNA containing the 3'-untranslated intron represents the predominant transcript .","gene":["P5CDh cDNA"],"gene_indices_start":[5],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4380,"text":"Carcinoembryonic antigen ( CEA ) procedures and clinical evaluation . pp .","gene":["Carcinoembryonic antigen","CEA"],"gene_indices_start":[0,27],"gene_indices_end":[24,30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4381,"text":"Functional recognition of 5' splice site by U4 \/ U6 . U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly .","gene":["U4 \/ U6 . U5 tri-snRNP"],"gene_indices_start":[44],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4383,"text":"Follow-up controls of luteinizing hormone ( LH ) , follicle stimulating hormone ( FSH ) , prolactin ( HPRL ) , oestradiol ( E2 ) , progesterone ( P ) and testosterone ( T ) in the catabolic and healing phase of burn disease .","gene":["follicle stimulating hormone","prolactin","HPRL","luteinizing hormone","FSH","LH"],"gene_indices_start":[22,44,51,82,90,102],"gene_indices_end":[41,46,79,85,99,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4385,"text":"The gene cat-86 , specifying chloramphenicol-inducible chloramphenicol acetyltransferase , is located on the 1 . 1-kilobase cloned DNA .","gene":["gene cat-86","chloramphenicol-inducible chloramphenicol acetyltransferase"],"gene_indices_start":[4,29],"gene_indices_end":[15,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4387,"text":"UDP-GlcNAc : alpha-6-D-mannoside beta-1 , 2-N-acetylglucosaminyltransferase II ( GnT II ; EC 2 . 4 . 1 . 143 ) is essential for the normal assembly of complex Asn-linked glycans .","gene":["UDP-GlcNAc","GnT II","EC 2 . 4 . 1 . 143","alpha-6-D-mannoside beta-1 , 2-N-acetylglucosaminyltransferase II"],"gene_indices_start":[0,13,81,90],"gene_indices_end":[10,78,87,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4388,"text":"The MET4 gene was cloned , and its sequence reveals that it encodes a protein related to the family of the bZIP transcriptional activators .","gene":["bZIP transcriptional activators","MET4"],"gene_indices_start":[4,107],"gene_indices_end":[8,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4389,"text":"This region of hsp90 mediates ATP-independent chaperone activity , overlaps the hsp90 dimerization domain , and includes structural elements important for steroid receptor interaction .","gene":["hsp90","chaperone","steroid receptor","hsp90 dimerization domain"],"gene_indices_start":[15,46,80,155],"gene_indices_end":[20,55,105,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4390,"text":"The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium .","gene":["mouse Notch 3","epidermal growth factor-repeats","Notch homologue"],"gene_indices_start":[10,26,55],"gene_indices_end":[25,39,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4391,"text":"GGS1 is the same gene as TPS1 which was identified as encoding a subunit of the trehalose-6-phosphate synthase \/ phosphatase complex and it is allelic to the fdp1 , byp1 , glc6 and cif1 mutations .","gene":["trehalose-6-phosphate synthase \/ phosphatase complex","GGS1","TPS1","byp1","glc6","fdp1"],"gene_indices_start":[0,25,80,158,165,172],"gene_indices_end":[4,29,132,162,169,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4392,"text":"Structure and expression of the alternative sigma factor , RpoN , in Rhodobacter capsulatus ; physiological relevance of an autoactivated nifU2-rpoN superoperon .","gene":["RpoN","nifU2-rpoN"],"gene_indices_start":[59,138],"gene_indices_end":[63,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4395,"text":"M-Ras interacted poorly in a yeast two-hybrid assay with multiple Ras effectors , including c-Raf-1 , A-Raf , B-Raf , phosphoinositol-3 kinase delta , RalGDS , and Rin1 .","gene":["A-Raf","RalGDS","c-Raf-1","M-Ras","B-Raf","Rin1","phosphoinositol-3 kinase delta","Ras"],"gene_indices_start":[0,66,92,102,110,118,151,164],"gene_indices_end":[5,69,99,107,115,148,157,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4396,"text":"Isolation and characterization of SRF accessory proteins .","gene":["SRF accessory proteins"],"gene_indices_start":[34],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4397,"text":"The 3 . 3-fold higher expression in the fetal heart than in the adult heart suggests that HFHZ mRNA is downregulated in the process of development .","gene":["HFHZ mRNA"],"gene_indices_start":[90],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4405,"text":"Antithrombin III deficiency : when substitute , when heparin ? Thrombosis ABC , 3 : The role of antithrombin III .","gene":["antithrombin III","Antithrombin III"],"gene_indices_start":[0,96],"gene_indices_end":[16,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4406,"text":"Identification of Ets- and notch-related subunits in GA binding protein .","gene":["Ets- and notch-related subunits","GA binding protein"],"gene_indices_start":[18,53],"gene_indices_end":[49,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4410,"text":"In a reconstituted human DNA repair system containing DNA polymerase beta and DNA ligase III-XRCC1 , accurate rejoining of a 3' mismatched base residue at a single-strand break is dependent on addition of the exonuclease .","gene":["DNA ligase III-XRCC1","DNA polymerase beta","exonuclease"],"gene_indices_start":[54,78,209],"gene_indices_end":[73,98,220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4411,"text":"Soluble FasR ligand-binding domain : high-yield production of active fusion and non-fusion recombinant proteins using the baculovirus \/ insect cell system .","gene":["FasR"],"gene_indices_start":[8],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4412,"text":"Furthermore , co-expression of both p46 and p54 subunits markedly altered the subcellular distribution of p46 ; co-expressed p46 was transported into the nucleus as efficiently as p54 .","gene":["p46","p54 subunits","p46","p54","p46"],"gene_indices_start":[36,44,106,125,180],"gene_indices_end":[39,56,109,128,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4414,"text":"These results support a model in which p53 protein contributes to the maintenance of genomic integrity through recombinational repair .","gene":["p53 protein"],"gene_indices_start":[39],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4415,"text":"Posttranslational regulation of Ty1 retrotransposition by mitogen-activated protein kinase Fus3 .","gene":["Ty1","mitogen-activated protein kinase Fus3"],"gene_indices_start":[32,58],"gene_indices_end":[35,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4416,"text":"Finally , we determined the genomic organization of the human TrxR2 gene , which consists of 18 exons spanning about 67 kb , and its chromosomal localization at position 22q11 . 2 .","gene":["human TrxR2 gene"],"gene_indices_start":[56],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4417,"text":"The 5' flanking region contains potential binding sites for TATA-binding protein , Sp1 , nuclear factor 1 ( NF1 ) , CAAT-box binding protein ( C \/ EBP ) , hepatocyte nuclear factors 1 and 5 ( HNF1 , HNF5 ) and activator proteins 1 and 2 ( AP1 , AP2 ) .","gene":["nuclear factor 1","AP2","NF1","C \/ EBP","hepatocyte nuclear factors 1 and 5","activator proteins 1 and 2","CAAT-box binding protein","Sp1","HNF5","AP1","HNF1","TATA-binding protein"],"gene_indices_start":[60,83,89,108,116,143,155,192,199,210,239,245],"gene_indices_end":[80,86,105,111,140,150,189,196,203,236,242,248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4418,"text":"The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase .","gene":["Type I deiodinase"],"gene_indices_start":[143],"gene_indices_end":[160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4423,"text":"However , calphostin C , a specific inhibitor of PKC , abolished the TPA-induced increase in CFI mRNA levels .","gene":["PKC","CFI mRNA"],"gene_indices_start":[49,93],"gene_indices_end":[52,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4425,"text":"Cytomegalovirus , Chlamydia pneumoniae , and Helicobacter pylori IgG antibodies and restenosis after stent implantation : an angiographic and intravascular ultrasound study .","gene":["IgG antibodies"],"gene_indices_start":[65],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4426,"text":"The mechanism by which E2-C represses E2-dependent enhancer activity most likely involves competition with E2 for binding to a common transcriptional regulatory site . ( ABSTRACT TRUNCATED AT 400 WORDS )","gene":["E2-dependent enhancer","E2-C","E2"],"gene_indices_start":[23,38,107],"gene_indices_end":[27,59,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4431,"text":"In this paper we describe properties of the cdc10-C4 mutant of the fission yeast Schizosaccharomyces pombe .","gene":["cdc10-C4 mutant of the fission yeast Schizosaccharomyces pombe"],"gene_indices_start":[44],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4432,"text":"Consistent with ErbB-2 being a shared receptor subunit , its tyrosine phosphorylation was increased by both heterologous ligands and it mediated a trans-inhibitory effect of NDF on EGF binding .","gene":["EGF","ErbB-2","NDF"],"gene_indices_start":[16,174,181],"gene_indices_end":[22,177,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4433,"text":"This conformer features a Type I beta-turn and has extensive hydrophobic contacts with the FKBP12 binding surface .","gene":["FKBP12"],"gene_indices_start":[91],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4434,"text":"Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae .","gene":["Pdr5 ATP-binding cassette multidrug transporter"],"gene_indices_start":[70],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4437,"text":"The degree of lung destruction , reflected by interstitial hemorrhage was assessed by measuring hemoglobin content in the fluid of the lavaged lungs .","gene":["hemoglobin"],"gene_indices_start":[96],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4438,"text":"To elucidate the functional significance of Fyn in the expression of viral promoters , we transfected a Fyn-expression vector together with a reporter plasmid containing the chloramphenicol acetyltransferase gene driven by HIV LTR into a human T cell line , Jurkat .","gene":["HIV LTR","chloramphenicol acetyltransferase gene","Fyn"],"gene_indices_start":[44,174,223],"gene_indices_end":[47,212,230],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4441,"text":"These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin \/ Lap18 gene .","gene":["stathmin \/ Lap18 gene","neuron-specific SCG10 gene"],"gene_indices_start":[49,146],"gene_indices_end":[75,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4442,"text":"We studied GSH-Px enzyme activity in serum after acute myocardial infarction ( AMI ) and unstable angina pectoris ( UAP ) .","gene":["GSH-Px enzyme"],"gene_indices_start":[11],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4443,"text":"The N-terminal 115 amino acids correspond to a putative DNA-binding domain and show significant sequence similarity with other cloned IFN response factors ( IRF-1 and IRF-2 ) .","gene":["IFN response factors","IRF-2","IRF-1"],"gene_indices_start":[134,157,167],"gene_indices_end":[154,162,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4447,"text":"NE and PR3 assist in the destruction of phagocytosed microorganisms , cleave the important connective-tissue protein elastin , and generate chemotactic activities by forming alpha 1-proteinase inhibitor complexes and elastin peptides .","gene":["connective-tissue protein elastin","alpha 1-proteinase inhibitor complexes","NE","PR3","elastin peptides"],"gene_indices_start":[0,7,91,174,217],"gene_indices_end":[2,10,124,212,233],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4448,"text":"They suggest that decreased steady-state levels of IME1 and IME2 mRNA were not merely the result of non-specific adverse affects on nucleic acid metabolism caused by the yvh1 disruption .","gene":["yvh1","IME1","IME2 mRNA"],"gene_indices_start":[51,60,170],"gene_indices_end":[55,69,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4449,"text":"Blood levels of melatonin , serotonin , cortisol , and prolactin in relation to the circadian rhythm of platelet serotonin uptake .","gene":["prolactin"],"gene_indices_start":[55],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4454,"text":"Polyadenylation of B4 RNA , which occurs very early during maturation , is limited to 150 residues , and it is this number that is required for polysomal recruitment .","gene":["B4 RNA"],"gene_indices_start":[19],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4455,"text":"In comparison of cDNA and genomic sequences four RNA editing events were found in both atp9 genes .","gene":["atp9 genes"],"gene_indices_start":[87],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4456,"text":"We show that these three gain-of-function mutants differ considerably in their ability to bypass the sex determination signal , with SxlM4 being the strongest and SxlM1 the weakest .","gene":["SxlM1","SxlM4"],"gene_indices_start":[133,163],"gene_indices_end":[138,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4461,"text":"In mammals , the Rb protein interacts specifically with D-type cyclins and regulates cell proliferation by binding and inhibiting E2F transcription factors .","gene":["E2F transcription factors","Rb protein","D-type cyclins"],"gene_indices_start":[17,56,130],"gene_indices_end":[27,70,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4462,"text":"The data imply that JAK \/ STAT signaling has a role in EBV-associated malignancies .","gene":["JAK \/ STAT"],"gene_indices_start":[20],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4467,"text":"Analysis for DNA-protein interactions by in vitro DNase-I footprinting identified a broad region of protection extending from nt -12 to +38 .","gene":["DNase-I"],"gene_indices_start":[50],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4468,"text":"Using himA mutants , we confirmed that IHF plays a role in the molybdate-dependent regulation of dmsA-lacZ expression in vivo .","gene":["dmsA-lacZ","himA mutants","IHF"],"gene_indices_start":[6,39,97],"gene_indices_end":[18,42,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4469,"text":"A heterologous promoter construct containing three repeats of a consensus Sp1 site , cloned upstream of a single copy of the ZII ( CREB \/ AP1 ) element from the BZLF1 promoter linked to the beta-globin TATA box , exhibited phorbol ester inducibility .","gene":["ZII","Sp1 site","beta-globin","CREB \/ AP1","BZLF1 promoter"],"gene_indices_start":[74,125,131,161,190],"gene_indices_end":[82,128,141,175,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4472,"text":"Identification and structure of the Marek's disease virus serotype 2 glycoprotein M gene : comparison with glycoprotein M genes of Herpesviridae family .","gene":["Marek's disease virus serotype 2 glycoprotein M gene","glycoprotein M genes"],"gene_indices_start":[36,107],"gene_indices_end":[88,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4473,"text":"Dimerization of Myf-5 with the ubiquitously expressed bHLH protein E12 not only increases the affinity for DNA but also stimulates transactivation independently of DNA binding .","gene":["E12","bHLH protein","Myf-5"],"gene_indices_start":[16,54,67],"gene_indices_end":[21,66,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4476,"text":"The mechanisms that govern the activation or suppression of the CD8 gene are likely to be central to the T cell development program .","gene":["CD8 gene"],"gene_indices_start":[64],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4477,"text":"A segmental analysis of the key regions of HLA-DR1 that control T cell allorecognition was performed by using a series of transfected cell lines expressing the products of recombinant DRB \/ H-2Eb genes , paired with either DR alpha or H-2E alpha .","gene":["HLA-DR1","H-2E alpha","DR alpha","recombinant DRB \/ H-2Eb genes"],"gene_indices_start":[43,172,223,235],"gene_indices_end":[50,201,231,245],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4479,"text":"To assess more specific PKA-dependent mediation of LH's contribution to combined hormonal drive , the LDL receptor ( -1076 to +11 bp ) reporter plasmid was cotransfected with a full-sequence rabbit muscle protein kinase inhibitor ( PKI ) minigene driven constitutively by a Rous sarcoma virus promoter .","gene":["LDL receptor ( -1076 to +11 bp ) reporter","PKI","LH's","full-sequence rabbit muscle protein kinase inhibitor"],"gene_indices_start":[51,102,177,232],"gene_indices_end":[55,143,229,235],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4480,"text":"A full-length human pim-1 cDNA was subcloned into the bacterial vector pGEX-2T and the Pim-1 protein expressed as a fusion product with bacterial glutathione S-transferase ( GST ) .","gene":["GST","Pim-1 protein","full-length human pim-1 cDNA","bacterial glutathione S-transferase"],"gene_indices_start":[2,87,136,174],"gene_indices_end":[30,100,171,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4482,"text":"Circulating thrombomodulin : current knowledge and future prospects .","gene":["thrombomodulin"],"gene_indices_start":[12],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4485,"text":"The mitochondrial regulatory region ( mrr ) located between the tRNAPhe and tRNAPro genes of mitochondrial DNA ( mtDNA ) is essential for regulation of replication and transcription of the mitochondrial genome .","gene":["mrr","tRNAPhe","tRNAPro genes","mitochondrial regulatory region"],"gene_indices_start":[4,38,64,76],"gene_indices_end":[35,41,71,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4486,"text":"In order to examine the potential role of transcriptional silencing during productive HSV-1 infection , recombinant viruses were generated in which wild-type or mutant ICP34 . 5 promoters controlling the expression of a chloramphenicol acetyltransferase reporter gene were inserted into the thymidine kinase gene of the viral genome .","gene":["thymidine kinase gene","chloramphenicol acetyltransferase reporter gene","wild-type or mutant ICP34 . 5 promoters"],"gene_indices_start":[148,220,291],"gene_indices_end":[187,267,312],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4487,"text":"The gene structure of Elk1 spans 15 . 2 kb and consists of seven exons and six introns .","gene":["Elk1"],"gene_indices_start":[22],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4491,"text":"We could demonstrate the involvement of cAMP-dependent protein kinase ( PKA ) in the phosphorylation of CDC25Mm in fibroblasts overexpressing this RasGEF as well as in mouse brain synaptosomal membranes .","gene":["CDC25Mm","PKA","RasGEF","cAMP-dependent protein kinase"],"gene_indices_start":[40,72,104,147],"gene_indices_end":[69,75,111,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4493,"text":"The cardiac myosin light chain-2 ( MLC-2 ) gene promoter contains several positive and negative cis-acting sequences that are involved in the regulation of its expression .","gene":["MLC-2","cardiac myosin light chain-2"],"gene_indices_start":[4,35],"gene_indices_end":[32,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4495,"text":"CONCLUSION : Our findings suggest that endometriosis increases soluble CD23 levels , which can be suppressed with either danazol or leuprolide acetate injection .","gene":["CD23"],"gene_indices_start":[71],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4499,"text":"This suggested that baboon liver class I ADH is of the same ancestral lineage as the human ADH-beta .","gene":["human ADH-beta","baboon liver class I ADH"],"gene_indices_start":[20,85],"gene_indices_end":[44,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4500,"text":"Nine DNA fragments that were specifically recognized and bound by histidine-tagged AdpA were isolated by cycles of a gel mobility shift-PCR method .","gene":["AdpA"],"gene_indices_start":[83],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4501,"text":"We conclude that pancreatic polypeptide and motilin responses to a meal are different in encopretic children than in children in the control group .","gene":["motilin","pancreatic polypeptide"],"gene_indices_start":[17,44],"gene_indices_end":[39,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4502,"text":"The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions .","gene":["AP-1","zta transactivator","ZRE sites"],"gene_indices_start":[4,133,142],"gene_indices_end":[22,137,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4504,"text":"The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development .","gene":["c-jun protooncogenes","c-fos"],"gene_indices_start":[36,46],"gene_indices_end":[41,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4505,"text":"The effect of the thromboxane A2 ( TXA2 ) \/ prostaglandin endoperoxide receptor antagonist , SQ 29 , 548 on pacing-induced ischemia was determined in anesthetized open-chest dogs .","gene":["thromboxane A2 ( TXA2 ) \/ prostaglandin endoperoxide receptor"],"gene_indices_start":[18],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4507,"text":"Two differentially expressed LNX messages encode overlapping proteins with predicted molecular masses of 80 kDa ( LNX ) and 70 kDa ( LNX-b ) .","gene":["80 kDa ( LNX )","LNX messages","70 kDa ( LNX-b )"],"gene_indices_start":[29,105,124],"gene_indices_end":[41,119,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4508,"text":"Recessive lethal mutations were isolated based upon failure to complement the recessive lethality of Df ( 3L ) RR2 , a deletion of the DRE region that removes 16-18 polytene chromosome bands .","gene":["DRE region"],"gene_indices_start":[135],"gene_indices_end":[145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4509,"text":"Therefore , the molecular mechanisms of the estrogen action that govern the lactoferrin gene expression differ between mouse and human .","gene":["lactoferrin gene"],"gene_indices_start":[76],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4512,"text":"Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor .","gene":["NF-E2 transcription factor","Fos","Small Maf proteins"],"gene_indices_start":[0,39,88],"gene_indices_end":[18,42,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4513,"text":"These and other data presented suggest that TAg 're-models' host cell transcription factors that are used early in viral infection , and thereby mimics an event that naturally occurs during transformation .","gene":["TAg"],"gene_indices_start":[44],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4514,"text":"One P1 genomic clone and six subsequent plasmid subclones were isolated and analyzed for the exon-intron organization of the Ctpct gene .","gene":["Ctpct gene"],"gene_indices_start":[125],"gene_indices_end":[135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4516,"text":"Mature mRNA for cytosolic phosphoenolpyruvate carboxykinase of the chicken is 2 . 8 kilobases in length , similar to that previously noted for mRNA coding for the same enzyme in the rat .","gene":["cytosolic phosphoenolpyruvate carboxykinase of the chicken"],"gene_indices_start":[16],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4517,"text":"No significant differences could be seen in response rates according to the concentration of estrogen receptors or presence of progesteron receptors in this group of patients .","gene":["progesteron receptors","estrogen receptors"],"gene_indices_start":[93,127],"gene_indices_end":[111,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4521,"text":"Molecular characterization of the 50- and 57-kDa subunits of the bovine vacuolar proton pump .","gene":["bovine vacuolar proton pump"],"gene_indices_start":[65],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4523,"text":"The E-box sequence in the SE2 fragment of the transferrin promoter was CATCTG and was similar in gel shifts to the consensus E-box elements ( CANNTG ) previously characterized .","gene":["transferrin promoter","SE2 fragment"],"gene_indices_start":[26,46],"gene_indices_end":[38,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4525,"text":"OBJECTIVE : To determine the association of depressive symptoms with HIV-related mortality and decline in CD4 lymphocyte counts among women with HIV .","gene":["CD4"],"gene_indices_start":[106],"gene_indices_end":[109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4527,"text":"Positive CRP test were seen .","gene":["CRP"],"gene_indices_start":[9],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4529,"text":"Surprisingly , TFIIIC alpha has no homology to any of the yeast TFIIIC subunits already cloned , suggesting a significant degree of evolutionary divergence for RNA polymerase III factors .","gene":["TFIIIC alpha","yeast TFIIIC subunits","RNA polymerase III factors"],"gene_indices_start":[15,58,160],"gene_indices_end":[27,79,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4531,"text":"The sequence-specific interaction of nuclear factor HiNF-D with this key proximal promoter element of the H4-FO108 gene is cell cycle regulated in normal diploid cells ( J .","gene":["H4-FO108 gene","nuclear factor HiNF-D"],"gene_indices_start":[37,106],"gene_indices_end":[58,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4534,"text":"Using homology cloning techniques , we identified a mouse homologue of E ( Pc ) , termed Epc1 , a yeast protein that we name EPL1 , and as well as additional ESTs from Caenorhabditis elegans , mice and humans .","gene":["Epc1","E ( Pc )","EPL1"],"gene_indices_start":[71,89,125],"gene_indices_end":[79,93,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4535,"text":"The promoter of the rat pgp2 \/ mdr1b gene has a GC-rich region ( pgp2GC ) that is highly conserved in mdr genes and contains an consensus Sp1 site .","gene":["mdr genes","pgp2GC","rat pgp2 \/ mdr1b gene","Sp1 site"],"gene_indices_start":[20,65,102,138],"gene_indices_end":[41,71,111,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4538,"text":"A polymorphic bipartite motif signals nuclear targeting of early auxin-inducible proteins related to PS-IAA4 from pea ( Pisum sativum ) .","gene":["PS-IAA4 from pea ( Pisum sativum )"],"gene_indices_start":[101],"gene_indices_end":[135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4543,"text":"Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana : nucleotide sequence and characterization .","gene":["Lysine-ketoglutarate reductase","saccharopine dehydrogenase"],"gene_indices_start":[0,35],"gene_indices_end":[30,61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4544,"text":"To test the feasibility of using liposomes to deliver therapeutic agents to the lungs , the effect of liposome-encapsulated superoxide dismutase ( SOD ) or catalase on pulmonary oxygen toxicity was studied in rats .","gene":["superoxide dismutase","catalase","SOD"],"gene_indices_start":[124,147,156],"gene_indices_end":[144,150,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4545,"text":"3 activities of the factor II molecule in the newborn infant at term .","gene":["factor II"],"gene_indices_start":[20],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4549,"text":"Chinese Spring ( CS ) carrying the Q gene to those of a chromosome deletion line of CS , namely , q5 , which lacks 15% of 5AL including the Q gene .","gene":["Q gene","Q gene"],"gene_indices_start":[35,140],"gene_indices_end":[41,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4550,"text":"The resulting R protein terminates five codons downstream of the frameshift site at the V protein stop codon .","gene":["V protein","R protein"],"gene_indices_start":[14,88],"gene_indices_end":[23,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4551,"text":"Here we report that expression of the I-POU \/ tI-POU message is maximal late in the embryonic phase of Drosophila development , and I-POU is the preferred splice variant .","gene":["I-POU \/ tI-POU message","I-POU"],"gene_indices_start":[38,132],"gene_indices_end":[60,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4553,"text":"Insulin-like growth factor-binding protein-2 ( IGF-BP-2 ) transcription in rat liver varies with developmental age and fasting .","gene":["IGF-BP-2","Insulin-like growth factor-binding protein-2"],"gene_indices_start":[0,47],"gene_indices_end":[44,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4555,"text":"These data indicate that the third intracellular loop of the rat GnRH-R is involved in receptor G ( q \/ 11 ) protein coupling and \/ or selectivity , and in the GGH ( 3 ) 1' cell line , this loop is also involved in signal transduction mediated through the Gs protein pathway .","gene":["rat GnRH-R","receptor G ( q \/ 11 ) protein","Gs protein pathway"],"gene_indices_start":[61,87,256],"gene_indices_end":[71,116,274],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4556,"text":"Administration of growth hormone leads to faster growth , but also faster bone maturation .","gene":["growth hormone"],"gene_indices_start":[18],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4557,"text":"Evidence from the structure of a number of cDNA clones , as well as S1 nuclease and primer extension studies supports the hypothesis that the PTHrP gene contains at least two mRNA transcription start points that define two putative regulatory domains .","gene":["S1 nuclease","PTHrP gene"],"gene_indices_start":[68,142],"gene_indices_end":[79,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4558,"text":"Since proteins containing TPR elements are typically involved in multiple protein-protein interactions , we suggest that the 102kD protein interacts within the tri-snRNP with both the U5 and U4 \/ U6 snRNPs , thus bridging the two particles .","gene":["TPR elements","U5 and U4 \/ U6 snRNPs","tri-snRNP"],"gene_indices_start":[26,160,184],"gene_indices_end":[38,169,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4559,"text":"The comparison of the expression patterns of the known Kv4 family members shows subtype specificity with significant overlaps .","gene":["Kv4 family members"],"gene_indices_start":[55],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4560,"text":"Some strains of A . parasiticus produced all four aflatoxins B1 B2 G1 G2 , while the other ones produced AF B1 + G1 only , with concentrations of aflatoxins from 0 . 1 to 450 mg \/ kg .","gene":["G1","aflatoxins","aflatoxins B1 B2 G1 G2","AF B1"],"gene_indices_start":[50,105,113,146],"gene_indices_end":[72,110,115,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4561,"text":"We have tested this possibility by constructing a consecutive series of cysteine substitutions in the Neu juxtamembrane domain in order to force dimerization along a series of interreceptor faces .","gene":["Neu juxtamembrane domain"],"gene_indices_start":[102],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4563,"text":"We have examined the ability of various NF-kappa B subunits to bind to , and activate transcription from , the IL-8 promoter .","gene":["NF-kappa B subunits","IL-8 promoter"],"gene_indices_start":[40,111],"gene_indices_end":[59,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4564,"text":"In another study , intravenous administration of devazepide , a specific cholecystokinin-A receptor antagonist , at a dose of 0 . 1 mg \/ kg \/ hr was begun 15 min before postprandial saline intake and continued for 1 hr .","gene":["cholecystokinin-A receptor"],"gene_indices_start":[73],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4565,"text":"In the icosahaedral MVMi capsid , this sequence forms the carboxy end of the amphipathic beta-strand I ( betaI ) , and all its basic residues are contiguously positioned at the face that in the unassembled subunit would be exposed to solvent .","gene":["beta-strand I","betaI"],"gene_indices_start":[89,105],"gene_indices_end":[102,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4566,"text":"UAS1 is the binding site for the transcriptional regulator Adr1p .","gene":["Adr1p","UAS1"],"gene_indices_start":[0,59],"gene_indices_end":[4,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4567,"text":"Both receptors utilize protein tyrosine kinases ( PTKs ) for the phosphorylation of various signaling molecules , a process that is critical for the function of both receptors .","gene":["PTKs","protein tyrosine kinases"],"gene_indices_start":[23,50],"gene_indices_end":[47,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4568,"text":"Because the Pit-1 sites in the hGH-N gene promoter are insufficient for such gene activation in vivo , these data suggested a unique chromatin-mediated developmental role for Pit-1 in the hGH LCR .","gene":["Pit-1","hGH LCR","Pit-1 sites","hGH-N gene promoter"],"gene_indices_start":[12,31,175,188],"gene_indices_end":[23,50,180,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4570,"text":"During organogenesis , HFH-8 expression is found in the splanchnic mesoderm in close apposition of the gut endoderm , suggesting a role in mesenchymal-epithelial induction of lung and gut morphogenesis .","gene":["HFH-8"],"gene_indices_start":[23],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4572,"text":"The IgA deficiency is combined with the IgE one .","gene":["IgA","IgE"],"gene_indices_start":[4,40],"gene_indices_end":[7,43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4573,"text":"Our results suggest that Anu2p is the yeast homologue of mammalian epsilon-COP and the abrupt accumulation of the ER membrane caused by a blockage of the early protein transport pathway leads to alteration of nuclear morphology of the budding yeast cells .","gene":["Anu2p","yeast homologue of mammalian epsilon-COP"],"gene_indices_start":[25,38],"gene_indices_end":[30,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4574,"text":"The penicillin binding proteins ( PBPs ) synthesize and remodel peptidoglycan , the structural component of the bacterial cell wall .","gene":["penicillin binding proteins","PBPs"],"gene_indices_start":[4,34],"gene_indices_end":[31,38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4577,"text":"Using an ELISA , we found that surfactant protein A ( SP-A ) was markedly elevated in the pneumonia patients .","gene":["surfactant protein A","SP-A"],"gene_indices_start":[31,54],"gene_indices_end":[51,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4579,"text":"Among the v-myc codons , the first 5 are derived from the noncoding 5' terminus of the second c-myc exon , and 412 codons correspond to the c-myc coding region .","gene":["c-myc","c-myc","v-myc"],"gene_indices_start":[10,94,140],"gene_indices_end":[15,99,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4580,"text":"A cDNA for a newly discovered pseudogene , closely related to the mouse mast cell chymases was isolated by polymerase chain reaction amplification from a mouse connective tissue-like mast cell line .","gene":["polymerase","mouse mast cell chymases"],"gene_indices_start":[66,107],"gene_indices_end":[90,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4582,"text":"Expression of the mouse TSH beta gene , therefore , gives rise to multiple mRNAs , each with a unique 5'-untranslated region .","gene":["mouse TSH beta gene"],"gene_indices_start":[18],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4586,"text":"Most of the expressed human E3 polypeptides ( five bands ) were found in the insoluble pellet while primarily full-length mature E3 was found in the soluble fraction .","gene":["full-length mature E3","human E3 polypeptides"],"gene_indices_start":[22,110],"gene_indices_end":[43,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4587,"text":"We show that a protein , UBC9 , interacts specifically with TEL in vitro and in vivo .","gene":["UBC9","TEL"],"gene_indices_start":[25,60],"gene_indices_end":[29,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4588,"text":"Thus , this reading frame was concluded to encode the precursor of mitochondrial fumarase .","gene":["mitochondrial fumarase"],"gene_indices_start":[67],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4589,"text":"By contrast , all proteins initiated with a methionine placed one residue upstream of the natural N terminus of PR failed to show specific proteolysis .","gene":["PR"],"gene_indices_start":[112],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4596,"text":"Recent molecular analysis has revealed that the S locus is highly polymorphic and contains several genes , i . e . , SLG , SRK , the as-yet-unidentified pollen S gene ( s ) , and other linked genes .","gene":["S locus","pollen S gene ( s )","SRK","SLG"],"gene_indices_start":[48,117,123,153],"gene_indices_end":[55,120,126,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4597,"text":"The major type involves activator proteins that bind to DNA adjacent to where the RNA polymerase ( RNAP ) holoenzyme binds , usually assisting in recruitment of the RNAP to the promoter .","gene":["RNA polymerase","RNAP","RNAP"],"gene_indices_start":[82,99,165],"gene_indices_end":[96,103,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4599,"text":"Gel retardation assays combined with DNase I footprinting and diethyl pyrocarbonate interference showed that a nuclear factor from differentiated C2 myotubes and BC3H1 myocytes recognized a conserved A + T-rich sequence within the peripheral activating region .","gene":["DNase I"],"gene_indices_start":[37],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4608,"text":"Competitive mobility shift assays using either alphaT3-1 nuclear extract or recombinant SF-1 protein clearly indicated that SF-1 is able to interact specifically with this GSE element positioned at -134 .","gene":["GSE element","SF-1","recombinant SF-1 protein"],"gene_indices_start":[76,124,172],"gene_indices_end":[100,128,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4611,"text":"Site-directed mutagenesis of the R2 protein was used to provide evidence that this motif is also part of the active site of the endonuclease encoded by this element .","gene":["R2 protein","endonuclease"],"gene_indices_start":[33,128],"gene_indices_end":[43,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4612,"text":"We determined whether the human StAR promoter is responsive to sterol regulatory element-binding proteins ( SREBPs ) .","gene":["sterol regulatory element-binding proteins","SREBPs","human StAR promoter"],"gene_indices_start":[26,63,108],"gene_indices_end":[45,105,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4613,"text":"We show that other cdc33 mutants also arrest in G1 .","gene":["cdc33 mutants"],"gene_indices_start":[19],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4619,"text":"In experiments with the D1 antagonist SCH 23390 , buprenorphine-induced depression was consistently blocked , but facilitation was unaffected .","gene":["D1"],"gene_indices_start":[24],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4621,"text":"Positioning this uORF , together with its accompanying Kozak sequences , between a heterologous promoter from SV40 and a CAT reporter gene resulted in marked inhibition of CAT protein production without a decrease in CAT mRNA .","gene":["CAT reporter gene","CAT protein","CAT mRNA"],"gene_indices_start":[121,172,217],"gene_indices_end":[138,183,225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4624,"text":"Specific hyperimmune globulins to pathogens such as Haemophilus influenzae and Streptococcus pneumoniae have also been studied .","gene":["hyperimmune globulins"],"gene_indices_start":[9],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4625,"text":"From day 30 after turnout , the PFB-group had significantly lower serum pepsinogen levels , which reflects the low degree of abomasal damage in these animals .","gene":["serum pepsinogen"],"gene_indices_start":[66],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4627,"text":"At the C-terminus of the protein is a domain that contains sequences very similar to those found in the breakpoint cluster region gene product , n-chimerin , and rho GAP , all of which have been shown to possess intrinsic GAP activity on small GTPases .","gene":["small GTPases","GAP","n-chimerin","rho GAP"],"gene_indices_start":[145,162,222,238],"gene_indices_end":[155,169,225,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4631,"text":"The expression analysis of the KlHIS4 gene under phosphate starvation or high adenine supply shows that factors , such as Bas1 or Bas2 , involved in the basal control may also operate in a different way in K . lactis .","gene":["KlHIS4 gene","Bas2","Bas1"],"gene_indices_start":[31,122,130],"gene_indices_end":[42,126,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4634,"text":"Oleate induced steady-state levels of M-CPT I mRNA 4 . 5-fold .","gene":["M-CPT I mRNA"],"gene_indices_start":[38],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4636,"text":"Homozygous null embryos also displayed abnormalities in heart development , consistent with the conclusion that Tek is necessary for endocardial \/ myocardial interactions during development .","gene":["Tek"],"gene_indices_start":[112],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4638,"text":"No homologs of other members of the Surfeit gene cluster were detected in close proximity to the D . melanogaster Surf-3 \/ rpL7a gene . ( ABSTRACT TRUNCATED AT 250 WORDS )","gene":["Surfeit gene cluster","D . melanogaster Surf-3 \/ rpL7a gene . ( ABSTRACT"],"gene_indices_start":[36,97],"gene_indices_end":[56,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4642,"text":"Serial levels of troponin T and the activity of CK-MB were measured 6 , 12 , 24 and 48 h after aortic unclamping .","gene":["CK-MB","troponin T"],"gene_indices_start":[17,48],"gene_indices_end":[27,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4643,"text":"We also show that activation of protein kinase A ( PKA ) signaling is sufficient to down-regulate caveolin-1 protein expression and promoter activity .","gene":["protein kinase A","caveolin-1 protein","PKA"],"gene_indices_start":[32,51,98],"gene_indices_end":[48,54,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4645,"text":"Significantly , the polymerase chain reaction results demonstrated that gene IV transcripts were associated with hepatic polysome fractions , indicating their active utilization in this tissue .","gene":["gene IV transcripts"],"gene_indices_start":[72],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4656,"text":"Patients with acute myocardial infarction had higher plasma concentrations of neutrophil elastase and the non-peroxide diene conjugated isomer of linoleic acid than normal volunteers or patients with stable ischaemic heart disease .","gene":["neutrophil elastase"],"gene_indices_start":[78],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4659,"text":"Plasma glucose , immunoreactive insulin ( IRI ) , C-peptide , glucagon , and GLP-1 levels at each time point during OGTT were measured .","gene":["GLP-1","immunoreactive insulin","glucagon","C-peptide","IRI"],"gene_indices_start":[17,42,50,62,77],"gene_indices_end":[39,45,59,70,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4660,"text":"The Drosophila insulin receptor homolog : a gene essential for embryonic development encodes two receptor isoforms with different signaling potential .","gene":["Drosophila insulin receptor homolog"],"gene_indices_start":[4],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4663,"text":"The absolute concentrations of alpha 2-plasmin inhibitor , alpha 2-macroglobulin , and antithrombin III increased with exercise ( all P less than 0 . 005 ) , but when concentrations were corrected for acute shifts of plasma water during exercise , the quantity of these inhibitors actually decreased ( all P less than 0 . 005 ) .","gene":["alpha 2-macroglobulin","alpha 2-plasmin","antithrombin III"],"gene_indices_start":[31,59,87],"gene_indices_end":[46,80,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4664,"text":"In Rat 1a cells , m1R stimulation of phospholipase C beta and the marked rise in intracellular calcium stimulated cyclic AMP ( cAMP ) synthesis , resulting in the activation of protein kinase A .","gene":["m1R","protein kinase","phospholipase C beta"],"gene_indices_start":[18,37,177],"gene_indices_end":[21,57,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4666,"text":"Vbeta segments are appended to DJbeta rearrangements , with little or no direct Vbeta to Jbeta joining , despite 12 \/ 23 compatibility of Vbeta 23-RSSs and Jbeta12-RSSs .","gene":["Jbeta","DJbeta rearrangements","Vbeta 23-RSSs","Jbeta12-RSSs","Vbeta segments","Vbeta"],"gene_indices_start":[0,31,80,89,138,156],"gene_indices_end":[14,52,85,94,151,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4671,"text":"The UAS of the AAC2 gene contains at least two distinct motifs for DNA-binding transcriptional activators , including one which is identical with the core HAP2 \/ 3 \/ 4 binding motif , and a second one with the ABF1 consensus binding sequence .","gene":["AAC2 gene","UAS","DNA-binding transcriptional activators","ABF1 consensus binding sequence","HAP2 \/ 3 \/ 4 binding motif"],"gene_indices_start":[4,15,67,155,210],"gene_indices_end":[7,24,105,181,241],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4672,"text":"At temperatures permissive for transformation , 6m2 cells contain P58gag produced from the 4 . 0-kilobase ( kb ) viral RNA genome and P85gag-mos translated from a 3 . 5-kb spliced mRNA .","gene":["P85gag-mos","P58gag"],"gene_indices_start":[66,134],"gene_indices_end":[72,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4673,"text":"The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP-CRP and the rrnBP1 UP element .","gene":["RNA polymerases","cAMP-CRP","rrnBP1 UP element"],"gene_indices_start":[18,135,152],"gene_indices_end":[33,143,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4675,"text":"In short-term cotransfections , a pFRTK-CAT target containing EBNA-1-binding sites from the EBV origin of plasmid replication , ori-P , was transactivated by a carboxy-terminal EBNA-1 construction ( amino acids 450 to 641 ) that also carried a c-myc nuclear localization signal .","gene":["ori-P","c-myc nuclear localization signal","pFRTK-CAT","carboxy-terminal EBNA-1 construction","EBNA-1-binding sites"],"gene_indices_start":[34,62,128,160,244],"gene_indices_end":[43,82,133,196,277],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4676,"text":"The atp 1 and atp 2 types of cDNA sequences were the most redundant among the 28 different isoperoxidases identified among about 200 peroxidase encoding ESTs .","gene":["peroxidase encoding ESTs","atp 2","atp 1","isoperoxidases"],"gene_indices_start":[4,14,91,133],"gene_indices_end":[9,19,105,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4679,"text":"Interestingly , the activated PDGF beta-receptor was found not to bind Crk proteins .","gene":["Crk proteins","PDGF beta-receptor"],"gene_indices_start":[30,71],"gene_indices_end":[48,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4681,"text":"The deduced 96-residue amino acid coding sequence of the murine HMG-I ( Y ) cDNA is very similar to the reported amino acid sequence of human HMG-I , except that it lacks 11 internal amino acids reported in the human protein .","gene":["HMG-I","HMG-I ( Y )"],"gene_indices_start":[64,142],"gene_indices_end":[75,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4682,"text":"Furthermore , SB203580 inhibited LPS-induced activation of Sp1 , as well as the promoter activity in cells transfected with a plasmid containing the Sp1 consensus sequence .","gene":["Sp1","Sp1"],"gene_indices_start":[59,149],"gene_indices_end":[62,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4683,"text":"It is now recognized that essentially all eukaryotic and prokaryotic genes whose 5'-flanking regions are known and that encode barbiturate-inducible proteins contain the Barbie box element .","gene":["Barbie box element"],"gene_indices_start":[170],"gene_indices_end":[188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4685,"text":"The structural study of peptides belonging to the terminal domains of histone H1 can be considered as a step toward the understanding of the function of H1 in chromatin .","gene":["H1","histone H1"],"gene_indices_start":[70,153],"gene_indices_end":[80,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4689,"text":"In the present study we demonstrated a unique mechanism of action of 8-Cl-cAMP in the regulation of these kinase isozymes in HL-60 human promyelocytic leukemia cells .","gene":["kinase isozymes"],"gene_indices_start":[106],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4692,"text":"Northern ( RNA ) blot analyses indicated that the cdh genes encoding the five subunits and an open reading frame ( ORF1 ) with unknown function are cotranscribed during growth on acetate .","gene":["cdh genes"],"gene_indices_start":[50],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4695,"text":"Finally , in situ RNA hybridization studies revealed a very specific pattern of EphA8 gene expression restricted to the rostral region of midbrain tectum during embryonic development .","gene":["EphA8 gene"],"gene_indices_start":[80],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4696,"text":"The 1 . 7 kb cloned fragment was sequenced and shown to contain the entire fliA gene .","gene":["fliA gene"],"gene_indices_start":[75],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4698,"text":"Since RCC1p acts as GNRP for Ran , a small nuclear GTPase of the ras superfamily , we have identified two homologs of Ran in S . cerevisiae ( CNR1 and CNR2 ) .","gene":["GNRP","CNR2","Ran","Ran","CNR1","RCC1p","ras superfamily","small nuclear GTPase"],"gene_indices_start":[6,20,29,37,65,118,142,151],"gene_indices_end":[11,24,32,57,80,121,146,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4701,"text":"Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered .","gene":["human Voltage-Dependent Anion Channel isoforms 1 and 2"],"gene_indices_start":[15],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4704,"text":"To determine whether P35 could activate the 39k promoter in the absence of IE1 , the p35 open reading frame was cloned under the control of the ie1 promoter .","gene":["P35","ie1 promoter","p35","IE1"],"gene_indices_start":[21,75,85,144],"gene_indices_end":[24,78,88,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4705,"text":"A previous report described that a 548-bp BglII-SmaI fragment has an SSO activity ( ori2 ; Kataoka et al . , Mol .","gene":["548-bp BglII-SmaI fragment"],"gene_indices_start":[35],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4707,"text":"Thus , TRAF2 initiates SAPK and p38 activation by binding two proximal protein kinases : GCK and RIP .","gene":["GCK","TRAF2","RIP","p38","protein kinases","SAPK"],"gene_indices_start":[7,23,32,71,89,97],"gene_indices_end":[12,27,35,86,92,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4710,"text":"The 52-protein subunit of T4 DNA topoisomerase is homologous to the gyrA-protein of gyrase .","gene":["gyrA-protein","gyrase","T4 DNA topoisomerase"],"gene_indices_start":[26,68,84],"gene_indices_end":[46,80,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4711,"text":"Intensive synthesis of PNA in the cells of microvascular wall evidenced of their high functional activity , and the synthesis of DNA in them showed their ability for proliferation , i . g . --for growth .","gene":["PNA"],"gene_indices_start":[23],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4713,"text":"Since the ETS domain , which is localized in the carboxy terminal region of the encoded protein , is 95% and 96% identical to that of PEA3 and ER81 , respectively , we named this new member 'Ets Related Molecule PEA3-like' ( ERM ) .","gene":["ERM","ER81","'Ets Related Molecule PEA3-like'","ETS domain","PEA3"],"gene_indices_start":[10,134,143,190,225],"gene_indices_end":[20,138,147,222,228],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4717,"text":"In patients with myalgia , Raynaud's syndrome , skin vasculitis and vascular diseases WFAg concentrations were higher than in patients without them .","gene":["WFAg"],"gene_indices_start":[86],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4718,"text":"The Y . lipolytica genomic POT1 gene was disrupted by replacing 120 bp of its coding sequence with 2 . 7 kbp of DNA including the Y . lipolytica LEU2 gene .","gene":["LEU2 gene","POT1"],"gene_indices_start":[27,145],"gene_indices_end":[31,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4719,"text":"Activated PKR may exist as a dimer and phosphorylates the eukaryotic translation initiation factor 2 alpha subunit ( cIF-2 alpha ) to inhibit polypeptide chain initiation .","gene":["cIF-2 alpha","PKR","eukaryotic translation initiation factor 2 alpha subunit"],"gene_indices_start":[10,58,117],"gene_indices_end":[13,114,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4720,"text":"After 24 hour incubation , total cell-associated IL-1Ra and IL-1 beta were measured by specific radioimmunoassay .","gene":["IL-1Ra","IL-1 beta"],"gene_indices_start":[49,60],"gene_indices_end":[55,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4721,"text":"SGPT , SGOT , and alkaline phosphatase concentrations were essentially normal in all subjects .","gene":["SGOT","SGPT","alkaline phosphatase"],"gene_indices_start":[0,7,18],"gene_indices_end":[4,11,38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4722,"text":"Weak allergenicity of recombinant hirudin CGP 39393 ( REVASC ) in immunocompetent volunteers .","gene":["recombinant hirudin CGP 39393"],"gene_indices_start":[22],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4723,"text":"The DNA sequencing of the recombinant clones revealed the expression of RXR alpha and RXR beta .","gene":["RXR beta","RXR alpha"],"gene_indices_start":[72,86],"gene_indices_end":[81,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4726,"text":"A 73 bp fragment ( X1 region ) of the PRB-1b promoter , located between positions -213 and -141 , was sufficient to confer ethylene responsiveness to the reporter gene .","gene":["PRB-1b promoter","73 bp fragment ( X1 region )"],"gene_indices_start":[2,38],"gene_indices_end":[30,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4728,"text":"Comparison with a recently described c-sis cDNA clone ( Collins et al . , Nature 316 , 748-750 ( 1985 ) ) revealed that the 1 . 9 kbp DNA region contained a large 5' c-sis exon of at least 1050 bp .","gene":["c-sis cDNA clone","5' c-sis exon"],"gene_indices_start":[37,163],"gene_indices_end":[53,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4729,"text":"This cluster consisted of four apparently unrelated ESTs and two genes , pregnancy-associated plasma protein-A ( PAPP-A ) and a novel gene ( tentatively named EST-YD1 ) .","gene":["PAPP-A","pregnancy-associated plasma protein-A","EST-YD1"],"gene_indices_start":[73,113,159],"gene_indices_end":[110,119,166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4730,"text":"The revertant TATA boxes accelerated the kinetics of HIV replication when present in the context of an LTR containing a Sp1 mutation ( deletion or site specific ) ; no effect was observed on the infectivity of wild-type HIV .","gene":["Sp1"],"gene_indices_start":[120],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4731,"text":"Higher CYP3A23 basal activity appears to be due to an E-box in 3A23SiteA that interacts with USF1 , a ubiquitous bHLH \/ leucine zipper transcription factor .","gene":["USF1","bHLH \/ leucine zipper transcription factor","3A23SiteA","CYP3A23"],"gene_indices_start":[7,63,93,113],"gene_indices_end":[14,72,97,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4734,"text":"To understand the basis for the increased cell surface stability compared with wild-type peptide and to understand the differences in T cell recognition between I1Y and I1F , we determined the x-ray crystal structures of the two class I MHC-peptide complexes .","gene":["class I MHC-peptide complexes","I1F","I1Y"],"gene_indices_start":[161,169,229],"gene_indices_end":[164,172,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4735,"text":"AgMNPV and Orgyia pseudotsugata MNPV ( OpMNPV ) are similar in terms of promoter structure and polyhedrin primary sequence , and the polyhedrin gene of both viruses is transcribed in the anti-clockwise direction in relation to their physical maps .","gene":["polyhedrin gene","polyhedrin primary sequence"],"gene_indices_start":[95,133],"gene_indices_end":[122,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4739,"text":"From 250 g of cells , we isolated 1 mg of PDH complex with a specific activity of 12 . 6 U \/ mg of protein .","gene":["PDH complex"],"gene_indices_start":[42],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4741,"text":"The histopathology and neovascularization did not appreciably differ between xenograft tumors derived from FGF4 over-expressing versus control transfectants .","gene":["FGF4"],"gene_indices_start":[107],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4743,"text":"Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene .","gene":["mouse pre-T-cell receptor alpha gene"],"gene_indices_start":[50],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4746,"text":"Therefore , it is hoped that by defining the transcriptional control of the L7 gene insights into the mechanisms that control functional fate and organization in the nervous system can be gained .","gene":["L7 gene"],"gene_indices_start":[76],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4747,"text":"We showed previously that a fusion protein ( GAL4-p40 ) containing the DNA-binding domain of GAL4 and sequences of chicken l kappa B-alpha ( p40 ) inhibits growth in the yeast Saccharomyces cerevisiae .","gene":["p40","GAL4-p40","GAL4","chicken l kappa B-alpha"],"gene_indices_start":[45,93,115,141],"gene_indices_end":[53,97,138,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4748,"text":"Activation of the SH2-containing protein tyrosine phosphatase , SH-PTP2 , by phosphotyrosine-containing peptides derived from insulin receptor substrate-1 .","gene":["insulin receptor substrate-1","SH-PTP2","SH2-containing protein tyrosine phosphatase"],"gene_indices_start":[18,64,126],"gene_indices_end":[61,71,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4749,"text":"We thus conclude that the NFAT RIR plays an essential dual role in DNA recognition and cooperative binding to AP-1 family transcription factors .","gene":["NFAT RIR","AP-1 family transcription factors"],"gene_indices_start":[26,110],"gene_indices_end":[34,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4751,"text":"After that report , carboxypeptidase D ( CPD ) was subsequently purified from bovine pituitary and characterized as a novel carboxypeptidase E ( CPE ) -like enzyme , with many characteristics in common with duck gp180 ( Song , L . , Fricker , L . D . , 1995 .","gene":["carboxypeptidase D","CPD","CPE","carboxypeptidase E","gp180"],"gene_indices_start":[20,41,124,145,212],"gene_indices_end":[38,44,142,148,217],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4754,"text":"In patients with osteomyelitis and joint empyema ( n = 48 ) PMN elastase had a sensitivity of 77% , which was only exceeded by that of the unspecific erythrocyte sedimentation rate ( sensitivity 89% ) .","gene":["PMN elastase"],"gene_indices_start":[60],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4755,"text":"Cytoplasmic dynein is a multisubunit , microtubule-dependent mechanochemical enzyme that has been proposed to function in a variety of intracellular movements , including minus-end-directed transport of organelles .","gene":["Cytoplasmic dynein"],"gene_indices_start":[0],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4756,"text":"The authors undertook a retrospective analysis of pathology with quantification of the percentage of papillary serous component ( % PSC ) and p53 expression .","gene":["p53"],"gene_indices_start":[142],"gene_indices_end":[145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4757,"text":"The maximum induction of ACC-oxidase transcripts occurred at about 6 h after excision , while the maximum enzyme activity was observed at 24 h .","gene":["ACC-oxidase transcripts"],"gene_indices_start":[25],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4758,"text":"TPO by itself did not activate ERK1 , ERK2 and protein kinase C ( PKC ) , whereas TPO directly enhanced the PKC-dependent activation of ERKs induced by other agonists including thrombin and phorbol esters , without affecting the PKC activation by those agonists .","gene":["PKC","protein kinase C","thrombin","PKC","ERK2","ERKs","ERK1","TPO","TPO"],"gene_indices_start":[0,31,38,47,66,82,136,177,229],"gene_indices_end":[3,35,42,63,69,85,140,185,232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4760,"text":"The complement C3a anaphylatoxin receptor ( C3aR ) is a seven-transmembrane G-protein coupled chemoattractant receptor that on binding the C3a peptide ligand mediates numerous cellular responses , including histamine release from mast cells . smooth muscle contraction , and the directed migration of eosinophils .","gene":["C3aR","seven-transmembrane G-protein coupled chemoattractant receptor","C3a peptide ligand","complement C3a anaphylatoxin receptor"],"gene_indices_start":[4,44,56,139],"gene_indices_end":[41,48,118,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4762,"text":"These results indicate that CSFHU can increase neutrophil counts by increasing the number and maturity of the marrow neutrophil precursors in some types of childhood chronic neutropenia .","gene":["CSFHU"],"gene_indices_start":[28],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4766,"text":"Nucleotide sequence analysis of R has revealed similarities to the R1 plasmid found in some South American maize races with RU cytoplasm , to the M1 plasmid found in one source of Zea luxurians teosinte , to the atp9 mitochondrial gene and its 3' flanking sequence , and also to a region 3' to the orf221 gene .","gene":["R","orf221 gene","atp9 mitochondrial gene"],"gene_indices_start":[32,212,298],"gene_indices_end":[33,235,309],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4769,"text":"Purified spleen GAP accelerated hydrolysis of GTP bound to recombinant ARF1 , ARF3 , ARF5 , and ARF6 ; no effect of NH2-terminal myristoylation was observed .","gene":["ARF6","recombinant ARF1","ARF5","ARF3","GAP"],"gene_indices_start":[16,59,78,85,96],"gene_indices_end":[19,75,82,89,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4770,"text":"Specifically , recombination at HMR was used to produce rings that lacked the E and I silencers .","gene":["HMR","E and I silencers"],"gene_indices_start":[32,78],"gene_indices_end":[35,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4777,"text":"Hydropathy analysis of KCC1 indicates structural homology to NKCC , including 12 transmembrane domains , a large extracellular loop with potential N-linked glycosylation sites , and cytoplasmic N- and C-terminal regions .","gene":["NKCC","KCC1"],"gene_indices_start":[23,61],"gene_indices_end":[27,65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4780,"text":"However , each promoter activated by IEP86 was synergistically affected by the addition of IEP72 .","gene":["IEP72","IEP86"],"gene_indices_start":[37,91],"gene_indices_end":[42,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4783,"text":"Activation of PKA by 8-bromo-cyclic AMP or forskolin , and inhibition of PKC by calphostin C , resulted in a significant decrease in 3TP activity as well as in vitro ERK kinase activity in CRAC .","gene":["ERK kinase","3TP","PKA","PKC"],"gene_indices_start":[14,73,133,166],"gene_indices_end":[17,76,136,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4785,"text":"We previously delineated a region in the fatty-acid synthase promoter , which was responsible for obesity-related overexpression of the fatty-acid synthase ( FAS ) gene , by negatively regulating the activity of the downstream promoter in lean but not obese rat fat cells .","gene":["fatty-acid synthase promoter","FAS","fatty-acid synthase"],"gene_indices_start":[41,136,158],"gene_indices_end":[69,155,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4787,"text":"Therefore , in a large animal model of permanent focal ischemia in which transfusion starts 30 min after ischemia , tetrameric cross-linked hemoglobin transfusion can augment oxygen transport to the ischemic cortex , but the increase can be delayed and not necessarily provide protection .","gene":["hemoglobin"],"gene_indices_start":[140],"gene_indices_end":[150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4788,"text":"One such element , 1P , was employed to clone from a rat pituitary cDNA expression library a novel 417-amino acid WD protein , designated PREB ( PRL regulatory element binding ) protein .","gene":["PREB ( PRL regulatory element binding ) protein","417-amino acid WD protein","1P"],"gene_indices_start":[19,99,138],"gene_indices_end":[21,124,185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4789,"text":"Thus , a critical question is how HOX proteins select the correct sets of target genes in vivo .","gene":["HOX proteins"],"gene_indices_start":[34],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4790,"text":"Two homologues of the rhombotin gene have now been isolated .","gene":["rhombotin gene"],"gene_indices_start":[22],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4791,"text":"Thus , the human D1A gene belongs to the category of tissue-specific , regulated genes that have housekeeping-type promoters .","gene":["human D1A gene"],"gene_indices_start":[11],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4792,"text":"As PP2A exerts a range of cellular functions including cell cycle regulation and cell fate determination , we were surprised to find that these embryos develop normally until postimplantation , around embryonic day 5 . 5 \/ 6 . 0 .","gene":["PP2A"],"gene_indices_start":[3],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4794,"text":"We also show that zygotically activated Xretpos transcripts are restricted to ventro-posterior specific regions and induced by UV-irradiation and BMP-4 overexpression in cycloheximide-dependent way . genesis 26 : 198-207 , 2000 .","gene":["BMP-4"],"gene_indices_start":[146],"gene_indices_end":[151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4802,"text":"The human immunodeficiency virus type 1 ( HIV-1 ) preferentially infects CD4+ T lymphocytes and may exist as a latent provirus within these cells for extended periods .","gene":["CD4+"],"gene_indices_start":[73],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4803,"text":"However , it is only one-half and one-third the size of the proteolipids from M . thermoautotrophicum and M . jannaschii , respectively . ahaK is expressed in Escherichia coli , and it is incorporated into the cytoplasmic membrane despite the different chemical natures of lipids from archaea and bacteria .","gene":["ahaK"],"gene_indices_start":[138],"gene_indices_end":[142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4806,"text":"Although the extracellular domain of the TSH-R is sufficient for high affinity binding of TSH , we conclude that the hyt mutation in the fourth transmembrane domain eliminates TSH binding .","gene":["TSH-R","TSH","TSH"],"gene_indices_start":[41,90,176],"gene_indices_end":[46,93,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4814,"text":"Proteasomes are the multisubunit protease involved in the generation of peptides presented by MHC class I molecules .","gene":["Proteasomes","protease","MHC class I molecules"],"gene_indices_start":[0,33,94],"gene_indices_end":[11,41,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4815,"text":"Degenerate primers homologous to highly conserved regions of known CYP3A sequences were used for initial RT-PCRs .","gene":["CYP3A sequences"],"gene_indices_start":[67],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4816,"text":"IFN-gamma was elevated during active TB when compared with healthy controls , declining during and after treatment .","gene":["IFN-gamma"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4817,"text":"Within the human enhancer , these two sites are located within the previously defined DNase I footprints , NFAT-1 and NFIL-2B , respectively .","gene":["NFIL-2B","DNase I footprints","NFAT-1"],"gene_indices_start":[86,107,118],"gene_indices_end":[104,113,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4818,"text":"Analysis of SRE oligonucleotide gel mobility shift assays with nuclear extracts from Sertoli cells demonstrated the presence of both the SRF and the ubiquitously expressed bHLH protein E12 \/ E47 .","gene":["E12 \/ E47","bHLH protein","SRF"],"gene_indices_start":[137,172,185],"gene_indices_end":[140,184,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4819,"text":"These results lead us to hypothesize that a single multisubunit TFIID protein supports transcriptional stimulation by diverse activation domains and from a TATA-less promoter .","gene":["multisubunit TFIID protein"],"gene_indices_start":[51],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4821,"text":"The ZnF20 cDNA hybridized to multiple transcripts in a thyroid cancer cell line ( 8 . 0 , 4 . 5 and 2 kb ) that increased after cycloheximide treatment and decayed < 2 h after addition of actinomycin D .","gene":["ZnF20 cDNA"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4822,"text":"This fragment contained the C-terminal 47 nucleotides of leuB , encoding 3-isopropylmalate dehydrogenase ; asd , encoding aspartate-beta-semialdehyde dehydrogenase ( Asd ) ; and orfA , whose product showed similarity to the Asd proteins from Vibrio spp .","gene":["Asd proteins from Vibrio spp","Asd","leuB","aspartate-beta-semialdehyde dehydrogenase","3-isopropylmalate dehydrogenase","asd"],"gene_indices_start":[57,73,107,122,166,224],"gene_indices_end":[61,104,110,163,169,252],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4823,"text":"Sp1 can activate transcription through immunoglobulin kappa-chain enhancer or P-selectin promoter NF-kappaB sites . p50 homodimers replace Sp1 from the P-selectin promoter by binding site competition and thereby either inhibit basal Sp1-driven expression or , in concert with Bcl-3 , stimulate expression .","gene":["P-selectin promoter","p50 homodimers","Sp1","NF-kappaB sites","P-selectin promoter","immunoglobulin kappa-chain enhancer","Sp1","Bcl-3"],"gene_indices_start":[0,39,78,98,116,139,152,276],"gene_indices_end":[3,74,97,113,130,142,171,281],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4824,"text":"Results of two-hybrid assays and electrophoretic mobility shift assays strongly suggest that all HD-Zip proteins of families I and II can form homodimers and also heterodimers with all HD-Zip proteins of the same family .","gene":["HD-Zip proteins","HD-Zip proteins"],"gene_indices_start":[97,185],"gene_indices_end":[112,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4827,"text":"This sequence possessed homology with a methylation-sensitive promoter element , Enh2 , present in the LTR of mouse intractisternal A-particles .","gene":["Enh2"],"gene_indices_start":[81],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4828,"text":"The p36 gene is at least 22 kb in length and has a coding sequence of approximately 1 kb , representing only 4 . 5% of the gene . ( ABSTRACT TRUNCATED AT 250 WORDS )","gene":["p36 gene"],"gene_indices_start":[4],"gene_indices_end":[12],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4829,"text":"Members of the mitogen activated protein ( MAP ) kinase family , extracellular signal-regulated kinase , stress-activated protein kinase-1 \/ c-Jun NH2-terminal kinase , and p38 , are central elements that transduce the signal generated by growth factors , cytokines , and stressing agents .","gene":["p38","stress-activated protein kinase-1 \/ c-Jun NH2-terminal kinase","mitogen activated protein ( MAP ) kinase family","growth factors","extracellular signal-regulated kinase"],"gene_indices_start":[15,65,105,173,239],"gene_indices_end":[62,102,166,176,253],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4830,"text":"To assess the function ( s ) of E74 during metamorphosis , we have isolated and characterized recessive loss-of-function mutations specific to each transcription unit .","gene":["E74"],"gene_indices_start":[32],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4833,"text":"Recently , our laboratory developed a screen that identified five multicopy suppressors that can rescue lethal strains of clathrin heavy chain-deficient yeast ( Chc - scd1-i ) to viability .","gene":["clathrin","Chc - scd1-i"],"gene_indices_start":[122,161],"gene_indices_end":[130,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4836,"text":"Cytokine-induced NF-kappa B DNA binding activity , RelA nuclear translocation , I kappa B alpha degradation , I kappa B serine 32 phosphorylation , and I kappa B kinase ( IKK ) activity were blocked by curcumin treatment .","gene":["NF-kappa B","RelA","IKK","I kappa B alpha","I kappa B kinase","I kappa B"],"gene_indices_start":[17,51,80,110,152,171],"gene_indices_end":[27,55,95,119,168,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4837,"text":"HPLC phosphopeptide mapping , amino acid sequencing , and site-directed mutagenesis determined that NCLK phosphorylates Ser ( 67 ) of I-1 .","gene":["NCLK","I-1"],"gene_indices_start":[100,134],"gene_indices_end":[104,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4838,"text":"Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase .","gene":["cyclin-dependent kinase phosphorylation site","human deoxyuridine triphosphate nucleotidohydrolase"],"gene_indices_start":[30,105],"gene_indices_end":[74,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4840,"text":"Taken together , our data indicate that multiple survival pathways are triggered via this receptor , whereas NF-kappaB \/ Rel and PI-3K are crucial for CD40-induced proliferation .","gene":["PI-3K","NF-kappaB","Rel"],"gene_indices_start":[109,121,129],"gene_indices_end":[118,124,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4841,"text":"The activity of Rac1 leads to STAT3 translocation to the nucleus coincident with STAT3-dependent gene expression .","gene":["Rac1","STAT3"],"gene_indices_start":[16,30],"gene_indices_end":[20,35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4842,"text":"In vivo dimethyl sulfate footprinting of the cyclin E promoter revealed several regions of protection and hypersensitivity that were unique to infected cells .","gene":["cyclin E promoter"],"gene_indices_start":[45],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4846,"text":"Aspirin intolerance : unaltered susceptibility of platelet cyclo-oxygenase to inhibition by aspirin in vitro .","gene":["platelet cyclo-oxygenase"],"gene_indices_start":[50],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4848,"text":"In SN-48 neuronal cells that express MR , GR , and 5-HT1A receptors , deletion or inactivation of the nGRE ( negative GRE ) eliminated negative regulation of the rat 5-HT1A or heterologous promoters by corticosteroids , whereas its inclusion conferred corticosteroid-induced inhibition to a heterologous promoter .","gene":["negative GRE","rat 5-HT1A","nGRE","GR","5-HT1A receptors","MR"],"gene_indices_start":[37,42,51,102,109,162],"gene_indices_end":[39,44,67,106,121,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4849,"text":"To evaluate the cost and benefits of screening tests for Chlamydia trachomatis in adolescent males , we developed a decision analysis model and compared the leukocyte esterase urine dipstick test with culture , with direct-smear fluorescent antibody ( DFA ) , and with the option of no screening ( no treatment ) .","gene":["leukocyte esterase"],"gene_indices_start":[157],"gene_indices_end":[175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4851,"text":"Initial screening of a rat liver cDNA library with an oligonucleotide probe derived from the rat SCP2 protein sequence revealed an 825-base pair cDNA clone coding for the complete SCP2 protein sequence .","gene":["SCP2","SCP2"],"gene_indices_start":[97,180],"gene_indices_end":[101,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4857,"text":"These results suggest that Thr115 may play an important role in the regulation of MyoD function under conditions of high mitogenesis .","gene":["MyoD"],"gene_indices_start":[82],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4859,"text":"Peptide sequences of the zinc finger protein Ttk and the transcription factor Adf-1 were obtained .","gene":["zinc finger protein Ttk","transcription factor Adf-1"],"gene_indices_start":[25,57],"gene_indices_end":[48,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4860,"text":"Endoscopic examinations , peripheral white blood cell ( WBC ) counts , and assays of myeloperoxidase activity ( MPO ) in homogenates of colon mucosa were performed after one week ( 4% DSS model ) and eight weeks ( 1% DSS model ) .","gene":["MPO","myeloperoxidase"],"gene_indices_start":[85,112],"gene_indices_end":[100,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4862,"text":"INO2 , a regulatory gene in yeast phospholipid biosynthesis , affects nuclear segregation and bud pattern formation .","gene":["INO2"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4863,"text":"We established that the 2 . 6 kb mRNA V-1 and the 2 . 3 kb GGT mRNA V-2 derive , by alternate splicing , from a primary transcript initiated on a distal promoter on the rat GGT gene .","gene":["2 . 3 kb GGT mRNA V-2","2 . 6 kb mRNA V-1","rat GGT gene"],"gene_indices_start":[24,50,169],"gene_indices_end":[41,71,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4865,"text":"Citrate synthase activity was increased in the medial head ( 81% , P < 0 . 001 ) and the red long head ( 88% , P < 0 . 001 ) of the triceps brachii muscle in R rats but not in the white long head ( 25% , P = 0 . 06 ) .","gene":["Citrate synthase"],"gene_indices_start":[0],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4866,"text":"These results suggest that mitochondrial presequences interact with the mt-hsp70 during or after mitochondrial protein import .","gene":["mt-hsp70"],"gene_indices_start":[72],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4869,"text":"In an attempt to understand Wee1 regulation during cell cycle , yeast two-hybrid screening was used to identify Wee1-binding protein ( s ) .","gene":["Wee1-binding protein ( s )","Wee1"],"gene_indices_start":[28,112],"gene_indices_end":[32,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4870,"text":"Alternatively , the similarity in apparent regulatory action of the genes may indicate allelic differences wherein the IS1112C Rf3 allele may differ from alleles of maintainer lines by the capability to regulate both orf107 and urf209 processing activities .","gene":["Rf3 allele","IS1112C","orf107","urf209"],"gene_indices_start":[119,127,217,228],"gene_indices_end":[126,137,223,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4871,"text":"This philosophy was instituted for the compound RP 73401 , a specific phosphodiesterase IV inhibitor , that was being developed simultaneously for delivery by both oral and pulmonary routes of administration .","gene":["phosphodiesterase IV"],"gene_indices_start":[70],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4872,"text":"We have previously demonstrated that expression of the gene for the reproductive neuropeptide , GnRH , is repressed by the glutamate \/ NO \/ cyclic GMP ( cGMP ) signal transduction pathway through cGMP-dependent protein kinase in the hypothalamic GnRH-secreting neuronal cell line GT1-7 .","gene":["GnRH","cGMP-dependent protein kinase"],"gene_indices_start":[96,196],"gene_indices_end":[100,225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4874,"text":"Decreased serum ceruloplasmin and copper levels in cervical dystonia .","gene":["serum ceruloplasmin"],"gene_indices_start":[10],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4877,"text":"Oncogenic signalling by E2F1 has recently been linked to stabilization and activation of the tumour suppressor p53 ( refs 1 , 3 , 4 ) .","gene":["E2F1","p53"],"gene_indices_start":[24,111],"gene_indices_end":[28,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4878,"text":"PPD-specific IgG subclass responses were evident to all four IgG subclasses .","gene":["IgG","PPD-specific IgG"],"gene_indices_start":[0,61],"gene_indices_end":[16,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4880,"text":"Similarly , we observed synthetic phenotypes between mutations in MIF2 and trans-acting mutations in three known yeast centromere protein genes-CEP1 \/ CBF1 \/ CPF1 , NDC10 \/ CBF2 , and CEP3 \/ CBF3B .","gene":["CEP3 \/ CBF3B","NDC10 \/ CBF2","yeast centromere protein genes-CEP1 \/ CBF1 \/ CPF1","MIF2"],"gene_indices_start":[66,113,165,184],"gene_indices_end":[70,162,177,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4882,"text":"Furthermore , in vivo and in vitro protein-protein interaction experiments have shown that SR33 protein interacts with itself and with SR45 protein but not with two other members ( SRZ21 and SRZ22 ) of the SR family that are known to interact with the Arabidopsis full-length U-70K only .","gene":["SRZ22","SR45 protein","SR33 protein","U-70K","SRZ21","SR family"],"gene_indices_start":[91,135,181,191,206,276],"gene_indices_end":[103,147,186,196,215,281],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4886,"text":"Overexpression of SCS1 could not complement an HSP60-null allele , indicating that suppression was not due to the bypassing of Hsp60 activity .","gene":["HSP60-null allele","SCS1","Hsp60"],"gene_indices_start":[18,47,127],"gene_indices_end":[22,64,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4888,"text":"Through Southern blot analyses of DNA from backcross and cogenic mice , recombinant inbred strains , and somatic cell hybrids , the genetic loci that produce the cyclin B1-related sequences ( designated loci Cycb1-rs1 to Cycb1-rs9 ) were mapped on mouse chromosomes 5 , 1 , 17 , 4 , 14 , 13 , 7 , X , and 8 , respectively .","gene":["Cycb1-rs9","loci Cycb1-rs1","cyclin B1-related sequences"],"gene_indices_start":[162,203,221],"gene_indices_end":[189,217,230],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4892,"text":"Identical effects were obtained when inhibitors and dominant negative mutants were tested on the -29 to +139 bp region of the cyclin D1 promoter .","gene":["cyclin D1 promoter"],"gene_indices_start":[126],"gene_indices_end":[144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4893,"text":"Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph .","gene":["beta-2 transferrin"],"gene_indices_start":[37],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4894,"text":"Expression of the human heat shock protein 70 gene ( hsp70 ) is induced by various kinds of stress and by oncogenes .","gene":["human heat shock protein 70 gene","hsp70"],"gene_indices_start":[18,53],"gene_indices_end":[50,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4896,"text":"We have investigated the requirements of the CH gene switch by characterizing two rearranged gamma 2b genes from a gamma 2b producing mouse myeloma ( MPC-11 ) .","gene":["gamma 2b","CH gene","rearranged gamma 2b genes"],"gene_indices_start":[45,82,115],"gene_indices_end":[52,107,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4897,"text":"Exchanging the human propeptide in this chimera with either the murine MIC-1 or TGF-beta1 propeptide resulted in secretion of the unprocessed , monomeric chimera , suggesting a specific interaction between the human MIC-1 propeptide and mature peptide .","gene":["TGF-beta1 propeptide","murine MIC-1","human MIC-1 propeptide"],"gene_indices_start":[64,80,210],"gene_indices_end":[76,100,232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4899,"text":"Syndecan-4 is a focal adhesion component , and this interaction may both localize PKC and amplify its activity at sites of forming adhesions .","gene":["PKC","Syndecan-4"],"gene_indices_start":[0,82],"gene_indices_end":[10,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4902,"text":"The VirR response regulator from Clostridium perfringens binds independently to two imperfect direct repeats located upstream of the pfoA promoter .","gene":["pfoA promoter","VirR response regulator"],"gene_indices_start":[4,133],"gene_indices_end":[27,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4904,"text":"These data suggest that AP-A may be potentially useful in the management of heart failure .","gene":["AP-A"],"gene_indices_start":[24],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4906,"text":"The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB \/ LAI on the immunogenicity of the envelope protein .","gene":["HIV-1 gp120 IIIB \/ LAI","envelope"],"gene_indices_start":[65,117],"gene_indices_end":[87,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4908,"text":"A marked decrease in the type 1 insulin-like growth factor ( IGF ) receptor ( IGF-IR ) occurs in prostate epithelial cells during transformation from the benign to the metastatic state .","gene":["type 1 insulin-like growth factor ( IGF ) receptor","IGF-IR"],"gene_indices_start":[25,78],"gene_indices_end":[75,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4909,"text":"Pokeweed antiviral protein ( PAP ) from Phytolacca americana is a highly specific N-glycosidase removing adenine residues ( A4324 in 28S rRNA and A2660 in 23S rRNA ) from intact ribosomes of both eukaryotes and prokaryotes .","gene":["28S rRNA","N-glycosidase","Pokeweed antiviral protein","23S rRNA","PAP"],"gene_indices_start":[0,29,82,133,155],"gene_indices_end":[26,32,95,141,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4910,"text":"We also identified Sp1 , Sp3 , and NGFI-A \/ Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness .","gene":["Tax","NGFI-A","Egr-1","Sp3","Sp1","TRE1"],"gene_indices_start":[19,25,35,44,106,125],"gene_indices_end":[22,28,41,49,110,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4912,"text":"The significance of these palindromic domains in this ORF is unclear but the coincidence of the end of one larger palindrome with the end of the translated protein sequence that has homology with the B chain of insulin suggests that the palindromes may divide the T2 protein into several functional units .","gene":["B chain","T2 protein","insulin"],"gene_indices_start":[200,211,264],"gene_indices_end":[207,218,274],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4913,"text":"In contrast , when the isoform containing the C epsilon4 domain joined directly to the M2 exon ( IgE grande ) is expressed in the J558L cell line , it is degraded intracellularly , suggesting a cell line-dependent regulation of secretion .","gene":["C epsilon4 domain","M2 exon","IgE grande"],"gene_indices_start":[46,87,97],"gene_indices_end":[63,94,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4916,"text":"SPP41 was cloned and sequenced and found to be essential . spp43 is allelic to the previously identified suppressor srn1 , which encodes a negative regulator of gene expression .","gene":["suppressor srn1","spp43","SPP41"],"gene_indices_start":[0,59,105],"gene_indices_end":[5,64,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4917,"text":"Thus , phosphodiesterase inhibitors that produce an opiate quasi-withdrawal syndrome potentiate interoceptive stimuli and weight loss associated with the withdrawal syndrome precipitated by naltrexone in morphine-dependent rats .","gene":["phosphodiesterase"],"gene_indices_start":[7],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4922,"text":"A DNA fragment encoding the DNA-binding domain ( amino acids 1-60 ) of the Escherichia coli fru transcriptional regulator was cloned into the pGEX-KT vector and expressed in frame with the fused gene encoding glutathione S-transferase .","gene":["glutathione S-transferase","Escherichia coli fru transcriptional regulator"],"gene_indices_start":[75,209],"gene_indices_end":[121,234],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4923,"text":"It is believed that these domains are important for directing specific protein-protein interactions necessary for the proper functioning of Src .","gene":["Src"],"gene_indices_start":[140],"gene_indices_end":[143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4924,"text":"Obesity was strongly associated with the proportions of nonprotein-bound and albumin-bound estradiol , and inversely associated with sex hormone binding globulin ( SHBG ) levels and the proportion of SHBG-bound estradiol .","gene":["SHBG","sex hormone binding globulin"],"gene_indices_start":[133,164],"gene_indices_end":[161,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4925,"text":"Although a carboxyl-terminal HSF transcriptional activation domain is critical for the activation of CUP1 transcription in response to both heat shock stress and glucose starvation , this region is dispensable for transient heat shock activation of at least two genes encoding members of the S . cerevisiae hsp70 family .","gene":["HSF","CUP1","hsp70 family"],"gene_indices_start":[29,101,307],"gene_indices_end":[32,105,319],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4927,"text":"This correlated with reduced levels of secreted hepatitis B e antigen and increased intracellular levels of core and Pol proteins and replicative HBV DNA intermediates .","gene":["hepatitis B e antigen","core","Pol proteins"],"gene_indices_start":[48,108,117],"gene_indices_end":[69,112,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4934,"text":"( iv ) Although UCRBP has been previously shown to act as a transcriptional repressor , we show here that UCRBP can also act as a positive transactivator of a reporter driven by UCR elements when used in co-transfection assays .","gene":["UCR elements","UCRBP","UCRBP"],"gene_indices_start":[16,106,178],"gene_indices_end":[21,111,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4935,"text":"RNase protection assays reveal that this gene , unr , is transcribed in the same direction as N-ras and that its 3' end is located just 130 base pairs away from the point at which N-ras transcription begins .","gene":["RNase","unr","N-ras","N-ras"],"gene_indices_start":[0,48,94,180],"gene_indices_end":[5,51,99,185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4936,"text":"Collectively , these data indicate that HIP is a membrane-associated HP-binding protein expressed on the surface of normal human uterine epithelia and uterine epithelial cell lines .","gene":["HIP"],"gene_indices_start":[40],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4937,"text":"The second mutation present in the original mutant proved to be an allele of a known gene , PBS2 , which encodes a putative protein kinase that functions in the high osmolarity stress pathway .","gene":["protein kinase","PBS2"],"gene_indices_start":[92,124],"gene_indices_end":[96,138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4938,"text":"Clinical implication of protein levels of IL-5 in induced sputum in asthmatic patients .","gene":["IL-5"],"gene_indices_start":[42],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4940,"text":"These properties indicate that Gle1 is an RNA-export factor and that Rev may mediate viral RNA export by mimicking the function of Gle1 .","gene":["Rev","Gle1","Gle1"],"gene_indices_start":[31,69,131],"gene_indices_end":[35,72,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4942,"text":"Co-administration of 5FU , angiotensin II and microspheres via the hepatic artery may reduce drug exposure in the systemic compartment and therefore may increase the therapeutic ratio of 5FU administration via the hepatic artery .","gene":["angiotensin II"],"gene_indices_start":[27],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4943,"text":"Specific binding of the protein factors to the sites , possibly to the three Mt sequences , may play an important role in the coordinate regulation of the transcription of nuclear genes encoding subunits responsible for mitochondrial oxidative phosphorylation .","gene":["Mt sequences"],"gene_indices_start":[77],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4945,"text":"Neutrophil : lymphocyte ratio , plasma haptoglobin , and CBG levels were greater ( P < 0 . 01 ) during the INITIAL period than during the PRE or POST periods but did not differ between treatments .","gene":["haptoglobin","CBG"],"gene_indices_start":[39,57],"gene_indices_end":[50,60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4948,"text":"The data indicate that calcitonin induced a beta-endorphin increase independent of enhanced corticotrophin-cortisol release .","gene":["calcitonin","beta-endorphin"],"gene_indices_start":[23,44],"gene_indices_end":[33,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4950,"text":"The plasmin-derived D ( approximately 105-kDa ) product , however , could be cross-linked into DD dimers .","gene":["plasmin-derived D ( approximately 105-kDa ) product","DD dimers"],"gene_indices_start":[4,95],"gene_indices_end":[55,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4951,"text":"Furthermore , the deletion of bcp from the chromosome had no effect on gcv-lacZ expression .","gene":["bcp","gcv-lacZ"],"gene_indices_start":[30,71],"gene_indices_end":[33,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4952,"text":"The amino-terminal region of E1A binds several high molecular weight proteins and inhibits the transcriptional coactivator function of p300 and the homologous cAMP response element ( CRE ) -binding protein .","gene":["cAMP response element ( CRE ) -binding protein","p300","E1A"],"gene_indices_start":[29,135,159],"gene_indices_end":[32,139,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4958,"text":"A mutant areA product truncated immediately after the last residue of the highly conserved GATA ( DNA-binding ) domain retains partial function .","gene":["mutant areA product","GATA"],"gene_indices_start":[2,91],"gene_indices_end":[21,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4959,"text":"Thus , the CCAAT box also has tissue-specific characteristics that assist in targeting expression of the alpha-subunit gene to trophoblasts .","gene":["alpha-subunit gene"],"gene_indices_start":[105],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4961,"text":"IL-1 and TNF increase AND-34 transcript levels in thymic cortical reticular , thymic nurse , and fibroblast cell lines .","gene":["TNF","IL-1","AND-34 transcript"],"gene_indices_start":[0,9,22],"gene_indices_end":[4,12,39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4964,"text":"It also suggests that there is another pathway which can activate SWI4 transcription in the absence of SWI6 .","gene":["SWI6","SWI4"],"gene_indices_start":[66,103],"gene_indices_end":[70,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4965,"text":"Furthermore , 45Ca-binding assays revealed that CCaMK directly binds Ca2+ .","gene":["CCaMK"],"gene_indices_start":[48],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4966,"text":"To analyze the regulatory activity of Gtx , we first identified the optimal Gtx-binding sequence using an in vitro DNA-binding assay .","gene":["Gtx","Gtx-binding sequence"],"gene_indices_start":[38,76],"gene_indices_end":[41,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4971,"text":"The retinoid Z receptor beta ( RZR beta ) , an orphan receptor , is a member of the retinoic acid receptor ( RAR ) \/ thyroid hormone receptor ( TR ) subfamily of nuclear receptors .","gene":["TR",") \/ thyroid hormone receptor","retinoid Z receptor beta","RZR beta","retinoic acid receptor","orphan receptor","RAR"],"gene_indices_start":[4,31,47,84,109,113,144],"gene_indices_end":[28,39,62,106,112,141,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4973,"text":"A reversed-phase high-performance liquid chromatographic ( HPLC ) method for the determination of cocaine metabolites produced in vitro by serum and liver esterases is described .","gene":["serum and liver esterases"],"gene_indices_start":[139],"gene_indices_end":[164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4974,"text":"The functions of isolated portions of the insulin , IAPP , and beta GK promoters were studied by using transient expression and DNA binding assays .","gene":["IAPP","beta GK promoters","insulin"],"gene_indices_start":[42,52,63],"gene_indices_end":[49,56,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4978,"text":"We have used the hydrophobic repeats of the HSF1 trimerization domain in the yeast two-hybrid protein interaction assay to identify heat shock factor binding protein 1 ( HSBP1 ) , a novel , conserved , 76-amino-acid protein that contains two extended arrays of hydrophobic repeats that interact with the HSF1 heptad repeats .","gene":["HSBP1","heat shock factor binding protein 1","HSF1 heptad repeats","HSF1 trimerization domain"],"gene_indices_start":[44,132,170,304],"gene_indices_end":[69,167,175,323],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4979,"text":"The CNXA domain is similar at the amino acid level to the Escherichia coli moaA gene product , while CNXC is similar to the E . coli moaC product , with both E . coli products encoded by different cistrons .","gene":["E . coli moaC product","CNXC","Escherichia coli moaA gene product","CNXA domain"],"gene_indices_start":[4,58,101,124],"gene_indices_end":[15,92,105,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4982,"text":"Chick brain actin depolymerizing factor ( ADF ) is a 19-kDa protein that severs actin filaments and binds actin monomers .","gene":["ADF","actin filaments","Chick brain actin depolymerizing factor","actin monomers"],"gene_indices_start":[0,42,80,106],"gene_indices_end":[39,45,95,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4983,"text":"CodY does not have any homologues in the data-bases .","gene":["CodY"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4985,"text":"The test for alpha-naphthyl esterase and quantitation of macrophages ( absolute number ) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule .","gene":["alpha-naphthyl esterase"],"gene_indices_start":[13],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4986,"text":"Here , we have more closely investigated transactivation of the human HSP70 promoter by Myb proteins .","gene":["human HSP70 promoter","Myb proteins"],"gene_indices_start":[64,88],"gene_indices_end":[84,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4993,"text":"The positive-acting global sulfur regulatory protein , CYS3 , of Neurospora crassa turns on the expression of a family of unlinked structural genes that encode enzymes of sulfur catabolism .","gene":["CYS3"],"gene_indices_start":[55],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4996,"text":"The minimal promoter of the RII beta gene was composed of two adjacent functional elements .","gene":["RII beta gene"],"gene_indices_start":[28],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":4998,"text":"Structure and expression of the mouse growth hormone receptor \/ growth hormone binding protein gene .","gene":["mouse growth hormone receptor \/ growth hormone binding protein gene"],"gene_indices_start":[32],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5002,"text":"Several features of 10 . 24 . 6 cells suggest that the mutation disrupts normal intracellular formation of peptide \/ DR complexes .","gene":["peptide \/ DR complexes"],"gene_indices_start":[107],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5006,"text":"This enabled the formation of stem-loop templates with the fusion point of the chimeric transcript in the loop and the use of MLL primers in two-sided PCR .","gene":["MLL"],"gene_indices_start":[126],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5007,"text":"We recently reported a placenta-specific enhancer in the human leukemia inhibitory factor receptor ( LIFR ) gene and now show detailed characterization of the 226-base pair enhancer ( -4625 \/ -4400 nucleotides ) .","gene":["human leukemia inhibitory factor receptor","LIFR"],"gene_indices_start":[57,101],"gene_indices_end":[98,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5010,"text":"The studied protein fragments consist of residues Arg183-His267 of the human ER and residues Lys438-Gln520 of the rat GR .","gene":["human ER","rat","GR"],"gene_indices_start":[71,114,118],"gene_indices_end":[79,117,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5012,"text":"Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53 .","gene":["Human cytomegalovirus immediate-early protein IE2","p53"],"gene_indices_start":[0,97],"gene_indices_end":[49,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5014,"text":"Sequence comparison of the 0 . 38 kb promoter sequence with the promoters of the Sm-E gene and U1 snRNA genes revealed several homologous motifs , suggesting that genes encoding the snRNP components may be coordinately regulated .","gene":["snRNP","Sm-E","U1 snRNA genes"],"gene_indices_start":[81,95,182],"gene_indices_end":[85,109,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5016,"text":"Identification of eotaxin-3 will further promote our understanding of the control of eosinophil trafficking and other CCR3-mediated biological phenomena .","gene":["eotaxin-3"],"gene_indices_start":[18],"gene_indices_end":[27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5019,"text":"Comparison with the bovine gene showed that the 5'-flanking region of the hATP1 gene has an unconserved guanine-cytosine ( GC ) rich region , including several binding motifs of transcriptional factors , such as Sp1 , AP-2 , and GCF .","gene":["hATP1 gene","Sp1","AP-2","GCF"],"gene_indices_start":[74,212,218,229],"gene_indices_end":[84,215,222,232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5020,"text":"Reconstitution of Raf-1 activity was observed only with kinase active Jak1 in both cell lines .","gene":["Raf-1","Jak1","kinase"],"gene_indices_start":[18,56,70],"gene_indices_end":[23,62,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5021,"text":"Binding of meAda is necessary to activate transcription of the adaptive response genes ; accordingly , in vitro transcription of aidB is dependent on the presence of meAda .","gene":["meAda","meAda","aidB"],"gene_indices_start":[11,129,166],"gene_indices_end":[16,133,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5022,"text":"Spatiotemporal expression of the PAX3 gene is tightly regulated during development .","gene":["PAX3 gene"],"gene_indices_start":[33],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5024,"text":"OBJECTIVES : 1 ) to determine serum ACE activity in patients with COPD treated with and without continuous ambulatory oxygen therapy ( CAOT ) ; 2 ) to verify whether there is a correlation between ACE and any hematological , spirometric or gasometric parameter .","gene":["serum ACE","ACE"],"gene_indices_start":[30,197],"gene_indices_end":[39,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5026,"text":"Furthermore , plasma fibrinogen levels increased by a mean of 17 . 6% , a potentially adverse effect of gemfibrozil that has not been previously reported .","gene":["fibrinogen"],"gene_indices_start":[21],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5027,"text":"This 5' splice site sequence was required for enhanced polyadenylation and was recognized by both U1 small nuclear ribonucleoproteins ( snRNPs ) and alternative splicing factor \/ splicing factor 2 ( ASF \/ SF2 ) .","gene":["alternative splicing factor","splicing factor 2","ASF","SF2","snRNPs","U1 small nuclear ribonucleoproteins"],"gene_indices_start":[98,136,149,179,199,205],"gene_indices_end":[133,142,176,196,202,208],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5028,"text":"One R-EST and one Pto-like sequence each mapped to two locations .","gene":["Pto-like sequence"],"gene_indices_start":[18],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5029,"text":"Expression of a dominant negative Smad2 significantly reduces the level of luciferase reporter activity induced by nodal treatment .","gene":["dominant negative Smad2","luciferase reporter"],"gene_indices_start":[16,75],"gene_indices_end":[39,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5031,"text":"The size of the mutant molecule corresponds to the unprocessed cytoplasmic precursor ( pre-super-pro-PrB ) , as detected in sec61 mutants , when translocation into the endoplasmic reticulum is blocked .","gene":["pre-super-pro-PrB","sec61 mutants"],"gene_indices_start":[87,124],"gene_indices_end":[104,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5032,"text":"Malonate decarboxylation in Malonomonas rubra involves the formation of malonyl-S- [ acyl-carrier protein ] from acetyl-S- [ acyl-carrier protein ] and malonate , carboxyltransfer to a biotin protein and its decarboxylation that is coupled to delta mu Na+ generation .","gene":["biotin protein","malonyl-S- [ acyl-carrier protein ]","acetyl-S- [ acyl-carrier protein ]"],"gene_indices_start":[72,113,185],"gene_indices_end":[107,147,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5033,"text":"Production of C mu RNAs , unlike mu mRNAs , does not require recombination with the joining region ( JH ) locus .","gene":["C mu RNAs","mu mRNAs","joining region ( JH ) locus"],"gene_indices_start":[14,33,84],"gene_indices_end":[23,41,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5034,"text":"Finally , a role for NF-kappaB in preventing apoptosis induced by ER calcium release was demonstrated by data showing that sAPPalpha prevents thapsigargin-induced apoptosis , an effect blocked by kappaB decoy DNA .","gene":["kappaB","sAPPalpha","NF-kappaB"],"gene_indices_start":[21,123,196],"gene_indices_end":[30,132,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5040,"text":"This dynamic response strongly suggests that the p53 and Rb tumor suppressor pathways are intact in HeLa cells and that repression of HPV E6 and E7 mobilizes these pathways in an orderly fashion to deliver growth inhibitory signals to the cells .","gene":["p53","E7","HPV E6","Rb"],"gene_indices_start":[49,57,134,145],"gene_indices_end":[52,59,140,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5041,"text":"Taken together , our data suggest that prostate carcinomas with the Ras \/ MAPK pathway activation might have a selective growth advantage by autocrine TGF-beta1 production .","gene":["TGF-beta1","Ras \/ MAPK"],"gene_indices_start":[68,151],"gene_indices_end":[78,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5042,"text":"Optima ) genomic library by hybridizing with elicitor-induced stilbene synthase cDNA as a probe .","gene":["stilbene synthase cDNA"],"gene_indices_start":[62],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5043,"text":"The GTPase activity of CDC42Ce is moderately stimulated by human n-chimaerin , a GTPase-activating protein for the related p21 rac1 .","gene":["CDC42Ce","human n-chimaerin","GTPase-activating protein","GTPase","p21 rac1"],"gene_indices_start":[4,23,59,81,123],"gene_indices_end":[10,30,76,106,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5044,"text":"Renin studies performed in 34 hypertensive patients and in a control group of 11 recipients showed that elevation of plasma renin activity and of plasma aldosterone level is frequent but difficult to interpret , particularly when a renal artery stenosis is observed .","gene":["plasma renin"],"gene_indices_start":[117],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5045,"text":"The CCAAT core sequence mutants in which both CIII and CI \/ CII were abolished , also increased the promoter activity .","gene":["CI \/ CII","CCAAT core sequence mutants","CIII"],"gene_indices_start":[4,46,55],"gene_indices_end":[31,50,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5048,"text":"The pattern and timing of CARP mRNA expression , including transient expression in the tongue at 14 . 5 days p . c . , coincides with that of Nkx2 . 5 \/ Csx ( a putative homolog of tinman , the Drosophila melanogaster gene responsible for cardiac development ) .","gene":["CARP mRNA","tinman","Nkx2 . 5 \/ Csx"],"gene_indices_start":[26,142,181],"gene_indices_end":[35,156,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5050,"text":"Mechanism of activation of the vav protooncogene . vav is a human locus that appears to be specifically expressed in cells of hematopoietic origin regardless of their differentiation lineage .","gene":["vav protooncogene","vav"],"gene_indices_start":[31,51],"gene_indices_end":[48,54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5052,"text":"This concept is supported by the identification of RH-like genes in non human primates .","gene":["RH-like genes"],"gene_indices_start":[51],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5053,"text":"The ultrastructural findings , as well as the urinary C-peptide excretion , confirmed that the glycemic effects should not be thought to be due to a direct action of the drugs used on the endocrine pancreas .","gene":["C-peptide"],"gene_indices_start":[54],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5055,"text":"Both functional analyses in undifferentiated and differentiated F9 cells and characterization of DNA-protein complexes in vitro have identified the sequence motifs GTGACT ( C ) , ATTGT , and GATA as the key transcription factor binding sites .","gene":["sequence motifs GTGACT ( C )","ATTGT","GATA"],"gene_indices_start":[148,179,191],"gene_indices_end":[176,184,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5057,"text":"The first gene , NSR1 , a previously identified gene , encodes a protein involved in ribosomal RNA maturation and possibly in transport of proteins into the nucleus .","gene":["NSR1"],"gene_indices_start":[17],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5058,"text":"Northern-blot analysis of mRNA from Avicel-grown N . patriciarum showed that xynB hybridized to a 3 . 4 kb mRNA species .","gene":["xynB"],"gene_indices_start":[77],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5060,"text":"To assess the relationship between G ( q ) \/ G ( 11 ) function with the phosphatidylinositol 3-kinase dependent pathway , expression of a dominant-interfering p85 regulatory subunit , as well as wortmannin treatment inhibited insulin-stimulated but not G ( q ) \/ Q209L-stimulated GLUT4-EGFP translocation .","gene":["phosphatidylinositol 3-kinase","p85 regulatory subunit","GLUT4-EGFP"],"gene_indices_start":[72,159,280],"gene_indices_end":[101,181,290],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5061,"text":"Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of translation efficiency .","gene":["DB sequence"],"gene_indices_start":[15],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5062,"text":"Northern blot analysis of LeMT ( A ) and LeMT ( B ) showed that transcripts of both MT-like genes were more abundant in leaves than roots in tomato plants grown without addition of extra metal ions , a characteristic of type II MTs .","gene":["LeMT ( A )","LeMT ( B )","type II MTs","MT-like genes"],"gene_indices_start":[26,41,84,220],"gene_indices_end":[36,51,97,231],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5063,"text":"Blood variables measured at eight intervals before , during , and after operation were as follows : seven plasma proteins , free hemoglobin , formed elements , and clotting functions .","gene":["hemoglobin"],"gene_indices_start":[129],"gene_indices_end":[139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5066,"text":"The various forms of sickle cell disease share the common feature of an abnormal globin chain that , under certain conditions such as hypoxia , results in the sickling of red blood cells and obstruction of blood vessels .","gene":["globin chain"],"gene_indices_start":[81],"gene_indices_end":[93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5067,"text":"No TATA box was found in the putative promoter region , but multiple GC boxes were found around the cap sites , supporting the previously inferred housekeeping nature of CYP51 gene and the existence of the multiple transcription initiation sites .","gene":["CYP51 gene"],"gene_indices_start":[170],"gene_indices_end":[180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5068,"text":"Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme ( CfiA ) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta-lactamase II .","gene":["Bacillus cereus beta-lactamase II","CfiA","CfiA"],"gene_indices_start":[67,142,151],"gene_indices_end":[71,146,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5070,"text":"The SH2 domain-containing inositol 5'-phosphatase ( SHIP ) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling .","gene":["SHIP","SH2 domain-containing inositol 5'-phosphatase","phosphoinositide 3-kinase","B cell receptor","p85 subunit"],"gene_indices_start":[4,52,72,87,156],"gene_indices_end":[49,56,83,112,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5077,"text":"Thus , dpp and omb promote both dorsal leg cell fate as well as transdetermination-competent leg disc cells .","gene":["omb","dpp"],"gene_indices_start":[7,15],"gene_indices_end":[10,18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5079,"text":"Based on mutational data and possible mRNA structure , we hypothesized about the effect of mRNA structure on translation of the two major C \/ EBPepsilon isoforms : p32 and p30 .","gene":["p30","p32","C \/ EBPepsilon isoforms"],"gene_indices_start":[138,164,172],"gene_indices_end":[161,167,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5082,"text":"Although the E-box consensus is minimally defined as CANNTG , the adjacent nucleotides of functional E-boxes are variable for genes regulated by the bHLH proteins .","gene":["CANNTG","bHLH proteins"],"gene_indices_start":[53,149],"gene_indices_end":[59,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5084,"text":"Far Western blot analysis suggested that the tandem SH2 domains of SHP2 bind to Gab1 in a specific orientation , in which the N-SH2 domain binds to phosphotyrosine ( Tyr ( P ) ) -627 and the C-SH2 domain binds to Tyr ( P ) -659 .","gene":["N-SH2 domain","Gab1","SH2 domains","SHP2","C-SH2 domain"],"gene_indices_start":[52,67,80,126,191],"gene_indices_end":[63,71,84,138,203],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5085,"text":"These results suggest that G beta gamma-stimulated Shc phosphorylation represents an early step in the pathway leading to p21ras activation , similar to the mechanism utilized by growth factor tyrosine kinase receptors .","gene":["growth factor tyrosine kinase receptors","p21ras","Shc"],"gene_indices_start":[51,122,179],"gene_indices_end":[54,128,218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5086,"text":"The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription .","gene":["Oct-2"],"gene_indices_start":[4],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5087,"text":"This sequence also confers VDR and vitamin D responsiveness to a heterologous promoter .","gene":["VDR"],"gene_indices_start":[27],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5089,"text":"Processivity of DNA synthesis by the mutant holoenzyme containing pcna-79 was unaffected on poly ( dA ) x oligo ( dT ) but was dramatically reduced on a natural template with secondary structure .","gene":["pcna-79"],"gene_indices_start":[66],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5090,"text":"The present treatment strategy in progressive disorders is mainly based on the complementary effect of intensive radiochemotherapy , autologous stem-cell transplantation and the rational use of cytokines , mostly colony-stimulating factors .","gene":["colony-stimulating factors"],"gene_indices_start":[213],"gene_indices_end":[239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5091,"text":"Competition electrophoretic mobility shift and immunoshift assays confirmed that NF1 factors present in nuclear extracts of HeLa and CV-1 cells bind to the BKV-MLP .","gene":["NF1 factors","BKV-MLP"],"gene_indices_start":[81,156],"gene_indices_end":[92,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5092,"text":"CKbeta4GT-II is predicted to encode a type II transmembrane glycoprotein of 43 kDa with five potential N-linked glycosylation sites .","gene":["type II transmembrane glycoprotein","CKbeta4GT-II"],"gene_indices_start":[0,38],"gene_indices_end":[12,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5093,"text":"Analysis of the binding of Lrp to a set of circularly permuted DNA fragments from this region indicates that Lrp induces DNA bending .","gene":["Lrp","Lrp"],"gene_indices_start":[27,109],"gene_indices_end":[30,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5094,"text":"Plasmids were constructed with the mouse promoter region linked to the reporter gene chloramphenicol acetyltransferase ( CAT ) , and transiently and stably transfected in the INS-1 cells .","gene":["CAT","reporter gene chloramphenicol acetyltransferase"],"gene_indices_start":[71,121],"gene_indices_end":[118,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5095,"text":"A set of peptides corresponding to the individual elements of secondary structure derived from the N-terminal domain of the ribosomal protein L9 have been synthesized .","gene":["ribosomal protein L9"],"gene_indices_start":[124],"gene_indices_end":[144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5099,"text":"Postprandial plasma enteroglucagon concentration after 90 minutes in untreated patients correlated positively to the faecal fat excretion ( r = 0 . 58 , p less than 0 . 02 ) .","gene":["plasma enteroglucagon"],"gene_indices_start":[13],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5100,"text":"In addition , the megabase region surrounding the dagA locus was mapped .","gene":["dagA locus"],"gene_indices_start":[50],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5101,"text":"In an attempt to investigate whether the intergenic region between the oleosin and a second open reading frame ( ORFII ) in Brassica napus ( L . ) is a divergent promoter , and also to characterize the ORFII , cDNA clones homologous to ORFII were isolated from a leaf cDNA library .","gene":["oleosin","cDNA clones homologous to ORFII","ORFII"],"gene_indices_start":[71,202,210],"gene_indices_end":[78,207,241],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5103,"text":"Furthermore , using transgenic mouse technology we localized independent cis-regulatory elements controlling the tissue-specific expression of Pax6 .","gene":["Pax6"],"gene_indices_start":[143],"gene_indices_end":[147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5105,"text":"In addition , we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals .","gene":["endogenous Ig lambdaL","kappaL chain gene loci","CDR3 sequences"],"gene_indices_start":[59,77,103],"gene_indices_end":[73,98,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5107,"text":"Thus , the consensus sequences for phosphatase regulation are 5'-GCACGTGGG-3' and 5'-GCACGTTTT-3' which differ from the binding sequences for the Cpflp protein required for transcription of the genes in methionine biosynthesis and for centromere function .","gene":["Cpflp","5'-GCACGTGGG-3'","5'-GCACGTTTT-3'","phosphatase"],"gene_indices_start":[35,62,82,146],"gene_indices_end":[46,77,97,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5108,"text":"We conclude from this study that Arix and NBPhox exhibit indistinguishable and independent transcriptional regulatory properties on the DBH promoter .","gene":["NBPhox","DBH promoter","Arix"],"gene_indices_start":[33,42,136],"gene_indices_end":[37,48,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5109,"text":"The human T cell leukemia \/ lymphotropic virus type 1 Tax protein represses MyoD-dependent transcription by inhibiting MyoD-binding to the KIX domain of p300 .","gene":["KIX domain","human T cell leukemia \/ lymphotropic virus type 1 Tax protein","p300"],"gene_indices_start":[4,139,153],"gene_indices_end":[65,149,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5110,"text":"With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting .","gene":["beta-2 transferrin"],"gene_indices_start":[25],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5111,"text":"This sequence is almost identical with that of human luteinizing hormone ( Sairam , M .","gene":["human luteinizing hormone"],"gene_indices_start":[47],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5112,"text":"However , little is known regarding the genomic organization and developmental expression of the caveolin gene family .","gene":["caveolin gene family"],"gene_indices_start":[97],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5114,"text":"The number of polymerases active in vitro at the E strand promoter was similar to the number of polymerases at the L strand promoter .","gene":["polymerases","L strand promoter","polymerases","E strand promoter"],"gene_indices_start":[14,49,96,115],"gene_indices_end":[25,66,107,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5115,"text":"Our data suggest that it may be possible to individualize hCG administration at midcycle by determining the number of follicles greater than 1 cm by ultrasound on cycle day 12 or 13 and giving hCG when serum E2 levels reach 1100 to 1200 pmol \/ l per follicle .","gene":["hCG","hCG"],"gene_indices_start":[58,193],"gene_indices_end":[61,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5116,"text":"An electrophoretic mobility shift assay was performed to characterize the binding property of TR2 and its truncated isoform .","gene":["TR2"],"gene_indices_start":[94],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5118,"text":"STAT5A mutations in the Src homology 2 ( SH2 ) and SH3 domains did not alter the BTK-mediated tyrosine phosphorylation .","gene":["Src homology 2","SH3 domains","STAT5A","SH2"],"gene_indices_start":[0,24,41,51],"gene_indices_end":[6,38,44,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5121,"text":"Based on the comparison of the predicted amino acid sequences of 1-sst and 1-fft with those of other plant fructosyl transferase genes , we postulate that both plant fructan genes have evolved from plant invertase genes .","gene":["1-fft","1-sst","fructan genes","invertase","fructosyl transferase genes"],"gene_indices_start":[65,75,107,166,204],"gene_indices_end":[70,80,134,179,213],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5124,"text":"Together with a considerably shortened and interrupted aromatic aa stretch in this region , these differences are discussed in terms of the peculiar affinity of cyanobacterial cytochrome oxidases for acidic c-type cytochromes .","gene":["cyanobacterial cytochrome oxidases","c-type cytochromes"],"gene_indices_start":[161,207],"gene_indices_end":[195,225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5125,"text":"Comparison of sequences from -215 to +1 bp identified consensus binding sites for the homeodomain transcription factor thyroid transcription factor-1 ( TTF-1 ) .","gene":["thyroid transcription factor-1","homeodomain transcription factor","TTF-1"],"gene_indices_start":[86,119,152],"gene_indices_end":[118,149,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5128,"text":"Purified PLB showed optimal lyase activity at pH 10 . 0 .","gene":["PLB","lyase"],"gene_indices_start":[9,28],"gene_indices_end":[12,33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5129,"text":"We now show that RNU2 fragility can be induced by transfection with an expression vector encoding Ad12 E1B 55 kDa alone but not by an E1 vector encoding all E1 products ( 3 E1A proteins , as well as the E1B 19 kDa and 55 kDa proteins ) .","gene":["E1","E1B","RNU2","E1 products","E1A proteins","Ad12 E1B"],"gene_indices_start":[17,98,134,157,173,203],"gene_indices_end":[21,106,136,168,185,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5131,"text":"The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate ( PMA ) and the phosphatase inhibitor , okadaic acid , in both HT-1080 fibrosarcoma and U-937 histiocytic cells .","gene":["PAI-2 gene","phosphatase","TNF-responsive genes"],"gene_indices_start":[4,34,157],"gene_indices_end":[14,54,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5132,"text":"Mutational analyses showed that in-frame stop codons introduced into five of seven RNA 2 ORFs did not affect accumulation of progeny LIYV RNA 1 or RNA 2 , confirming that RNA 2 does not encode proteins necessary for LIYV RNA replication .","gene":["RNA 2","LIYV RNA","RNA 2","LIYV RNA 1","RNA 2 ORFs"],"gene_indices_start":[83,133,147,171,216],"gene_indices_end":[93,143,152,176,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5135,"text":"Because of the increased CPK activity found in normal newborns , screening for Duchenne-type muscular dystrophy should be postponed for a few weeks after delivery .","gene":["CPK"],"gene_indices_start":[25],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5136,"text":"CYC2 encodes a 24-kDa protein that has sequence identity to the Neurospora crassa PREG1 and the S . cerevisiae PHO80 cyclin .","gene":["Neurospora crassa PREG1","CYC2","S . cerevisiae PHO80 cyclin"],"gene_indices_start":[0,64,96],"gene_indices_end":[4,87,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5137,"text":"Similarly , overexpression of increasing concentration of COUP-TFI , but not COUP-TFI delta35 , can squelch the silencing activity of the unliganded TRbeta .","gene":["COUP-TFI delta35","COUP-TFI","TRbeta"],"gene_indices_start":[58,77,149],"gene_indices_end":[66,93,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5143,"text":"We have examined by in vitro footprinting a region located downstream of the human immunodeficiency virus , type 1 ( HIV-1 ) promoter found to be hypersensitive to DNase I digestion in vivo .","gene":["DNase I"],"gene_indices_start":[164],"gene_indices_end":[171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5144,"text":"Sequencing of the three pag-3 alleles showed that two apparent null alleles encode a nonsense mutation before the zinc fingers and a missense mutation in the fourth zinc finger that changes a coordinating histidine to a tyrosine .","gene":["pag-3 alleles"],"gene_indices_start":[24],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5146,"text":"Dialyzable transfer factor .","gene":["transfer factor"],"gene_indices_start":[11],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5147,"text":"Together , these results indicate that IL-1 beta induces VEGF gene expression at both transcriptional and post-transcriptional levels , and IL-1 beta evokes p38 MAPK and JNK signalings , which in turn stimulate the transcription of the VEGF gene through Sp1-binding sites .","gene":["VEGF gene","IL-1 beta","Sp1-binding sites","p38 MAPK","VEGF gene","IL-1 beta","JNK"],"gene_indices_start":[39,57,140,157,170,236,254],"gene_indices_end":[48,66,149,165,173,245,271],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5148,"text":"We measured basal plasma prolactin concentrations ( in samples obtained during the early follicular phase ) in 25 normal ( control ) women and in a similar group of 40 patients with a long-standing history of infertility .","gene":["prolactin"],"gene_indices_start":[25],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5149,"text":"We report here the discovery of a new actin-related gene in this organism , which we have named ACT4 .","gene":["ACT4","actin-related gene"],"gene_indices_start":[38,96],"gene_indices_end":[56,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5151,"text":"Polypeptide growth factors and cytokines mediate their biochemical functions through their responsive receptors .","gene":["Polypeptide growth factors"],"gene_indices_start":[0],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5153,"text":"PPAR gamma mRNA levels were reduced by 95% with 3 nM TNF alpha treatment for 24 h .","gene":["TNF alpha","PPAR gamma mRNA"],"gene_indices_start":[0,53],"gene_indices_end":[15,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5154,"text":"We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element ( HS-40 ) located 40 kb upstream of the zeta 2 globin gene .","gene":["zeta 2 globin","alpha globin regulatory element","HS-40","zeta 2 globin gene"],"gene_indices_start":[62,93,127,165],"gene_indices_end":[75,124,132,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5155,"text":"The HiNF-D ( CDP \/ cut ) complex with the H4 promoter is immunoreactive with antibodies against CDP \/ cut and pRB but not p107 , whereas the CDP \/ cut complex with a nonhistone promoter ( gp91-phox ) reacts only with CDP and p107 antibodies .","gene":["nonhistone promoter","p107","p107","HiNF-D ( CDP \/ cut ) complex","CDP","CDP \/ cut complex","H4 promoter","pRB","CDP \/ cut","gp91-phox"],"gene_indices_start":[4,42,96,110,122,141,166,188,217,225],"gene_indices_end":[32,53,105,113,126,158,185,197,220,229],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5157,"text":"Adding phytase and nP improved the orderliness of development , mineralization and arrangement of cartilage and bone cells , and alleviated the effects of P deficiency on the histological and gross structure of the tibias .","gene":["phytase"],"gene_indices_start":[7],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5158,"text":"Characterization of the microtubule binding domain of microtubule actin crosslinking factor ( MACF ) : identification of a novel group of microtubule associated proteins .","gene":["microtubule associated proteins","microtubule actin crosslinking factor","microtubule binding domain","MACF"],"gene_indices_start":[24,54,94,138],"gene_indices_end":[50,91,98,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5159,"text":"Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins .","gene":["Somatostatin gene"],"gene_indices_start":[0],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5161,"text":"Apart from iron regulation , sodA expression was affected by changes in DNA topology induced by coumermycin A but not by the global virulence regulatory Bvg system .","gene":["sodA","Bvg system"],"gene_indices_start":[29,153],"gene_indices_end":[33,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5163,"text":"The wild-type and altered forms of the F protein were expressed in BHK-21 and HeLa T4 cells by use of the recombinant vaccinia virus-encoding T7 polymerase system .","gene":["F protein","recombinant vaccinia virus-encoding T7 polymerase"],"gene_indices_start":[39,106],"gene_indices_end":[48,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5164,"text":"Nuclear localization and protein sequence similarities suggested that the SPT2 \/ SIN1 protein may be related to the nonhistone chromosomal protein HMG1 .","gene":["nonhistone chromosomal protein HMG1","SPT2 \/ SIN1 protein"],"gene_indices_start":[74,116],"gene_indices_end":[93,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5166,"text":"These results suggest that , for the HML ARS cluster ( ARS303 , ARS320 , and ARS302 ) , inactivity of origins is independent of local transcriptional silencing , even though origins and silencers share key cis- and trans-acting components .","gene":["ARS cluster","HML","ARS303","ARS302","ARS320"],"gene_indices_start":[37,41,55,64,77],"gene_indices_end":[40,52,61,70,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5167,"text":"Finally , we demonstrate that C \/ EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells . ( ABSTRACT TRUNCATED AT 400 WORDS )","gene":["GM-CSF receptor alpha","C \/ EBP alpha"],"gene_indices_start":[30,64],"gene_indices_end":[43,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5171,"text":"Sequences required for interaction of mu2 and CTLA-4 were localized to residues , 161TTGVY in CTLA-4 ; this sequence is N-terminal to , but overlaps with , a previously identified SH2 binding motif , 165YVKM , involved in CTLA-4 signaling .","gene":["CTLA-4","mu2","161TTGVY","SH2 binding motif","CTLA-4","CTLA-4","165YVKM"],"gene_indices_start":[38,46,82,94,180,200,222],"gene_indices_end":[41,52,90,100,197,207,228],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5173,"text":"Cytosolic extracts from a variety of mammalian cell lines ( monkey Cos7 , several mouse fibrosarcomas and human HeLa S3 ) demonstrated similar TGF-beta 1 dependent RNA-protein band shifts as cell extract from BALB \/ c 3T3 mouse fibroblasts .","gene":["TGF-beta 1"],"gene_indices_start":[143],"gene_indices_end":[153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5176,"text":"Recombinant HRMT1L2 protein encoded by the most common 5'-variant exhibited methyltransferase activity in vitro .","gene":["methyltransferase","Recombinant HRMT1L2 protein"],"gene_indices_start":[0,76],"gene_indices_end":[27,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5179,"text":"SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase .","gene":["SCF ubiquitin ligase","SKP1-SnRK protein kinase"],"gene_indices_start":[0,77],"gene_indices_end":[24,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5182,"text":"Moreover , the same mutations alter the structure of junB 5' flanking DNA within chromatin .","gene":["junB"],"gene_indices_start":[53],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5184,"text":"Basal FSH and LH levels were significantly lower in addicts ; after GnRH stimulation the addicts' FSH and LH values increased but not significantly compared to controls .","gene":["GnRH","LH","LH","FSH","FSH"],"gene_indices_start":[6,14,68,98,106],"gene_indices_end":[9,16,72,101,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5186,"text":"Mitogen-activated protein ( MAP ) kinase phosphatase-3 ( MKP-3 ) is a dual specificity phosphatase that inactivates extracellular signal-regulated kinase ( ERK ) MAP kinases .","gene":["MAP kinases","Mitogen-activated protein ( MAP ) kinase phosphatase-3","MKP-3","ERK","extracellular signal-regulated kinase","phosphatase"],"gene_indices_start":[0,57,87,116,156,162],"gene_indices_end":[54,62,98,153,159,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5188,"text":"Furthermore , MOM-4 and TAK1 bind related proteins that promote their kinase activities .","gene":["TAK1","MOM-4","kinase"],"gene_indices_start":[14,24,70],"gene_indices_end":[19,28,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5190,"text":"Furthermore , unlike the case for HIS3 where only a limited subset of TATA-like sequences can activate transcription in conjunction with GCN4p , many divergent TATA-like sequences allowed GCN4p activation of TRP3 .","gene":["TATA-like sequences","GCN4p","GCN4p","TATA-like sequences","TRP3","HIS3"],"gene_indices_start":[34,70,137,160,188,208],"gene_indices_end":[38,89,142,179,193,212],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5191,"text":"The peptide sequences reveal that the factor consists of GABP alpha and GABP beta 1 with Ets and Notch motifs , respectively .","gene":["GABP alpha","GABP beta 1","Notch motifs","Ets"],"gene_indices_start":[57,72,89,97],"gene_indices_end":[67,83,92,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5192,"text":"The ubiquitous transcription factor Oct-1 forms complexes with an octamer motif present within FPIV by gel shift analysis with liver and kidney extracts , making Oct-1 an intriguing candidate for partnership in androgen regulation .","gene":["Oct-1","Oct-1"],"gene_indices_start":[36,162],"gene_indices_end":[41,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5196,"text":"We report the isolation of genomic and cDNA clones of the light-independent Sn : bol3 allele .","gene":["Sn : bol3 allele"],"gene_indices_start":[76],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5198,"text":"A receptor-like protein kinase , OsPK10 , has been cloned from rice ( Oryza sativa ) .","gene":["OsPK10","receptor-like protein kinase"],"gene_indices_start":[2,33],"gene_indices_end":[30,39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5199,"text":"Therefore , the strD and strE genes could serve as universal probes indicative of the presence of biosynthetic capacity for 6-deoxyhexose moieties .","gene":["strE genes","strD"],"gene_indices_start":[16,25],"gene_indices_end":[20,35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5205,"text":"It is concluded that suppression of elevated prolactin levels in progressive metastatic breast cancer patients is not effective in restoring tumor sensitivity to chemotherapy .","gene":["prolactin"],"gene_indices_start":[45],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5213,"text":"TbRAB31 behaviour was also studied during the cell cycle ; TbRAB31 always localised to a discrete structure that duplicated very early in mitosis and relocated to daughter cells in a coordinate manner with the basal body and kinetoplast , suggesting the involvement of microtubules .","gene":["TbRAB31","TbRAB31"],"gene_indices_start":[0,59],"gene_indices_end":[7,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5214,"text":"Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors , Gal4 and general regulatory factor I \/ repressor \/ activator site binding protein 1 \/ translation upstream factor .","gene":["general regulatory factor I \/ repressor \/ activator site binding protein 1 \/ translation upstream factor","Gal4","Yeast Gal11 protein"],"gene_indices_start":[0,106,115],"gene_indices_end":[19,110,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5216,"text":"The activity of serum lipase and amylase distinctly increased at 3 h and went up to the maximum at 12 h after injection of Na-Tc .","gene":["amylase","serum lipase"],"gene_indices_start":[16,33],"gene_indices_end":[28,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5217,"text":"Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders .","gene":["TNRs"],"gene_indices_start":[32],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5218,"text":"This slow progression through the early G1-phase resulted in decreased phosphorylation of the RB protein and subsequent delay into the S phase transition .","gene":["RB protein"],"gene_indices_start":[94],"gene_indices_end":[104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5219,"text":"The RAD18 gene open reading frame encodes a protein of 487 amino acids , with a calculated molecular weight of 55 , 512 .","gene":["RAD18 gene open reading frame"],"gene_indices_start":[4],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5222,"text":"The partial sequence of the 62-kDa nuclear pore glycoprotein shows little similarity to other characterized proteins and elucidates structural features of a member of the family of nuclear pore glycoproteins .","gene":["62-kDa nuclear pore glycoprotein","nuclear pore glycoproteins"],"gene_indices_start":[28,181],"gene_indices_end":[60,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5224,"text":"In order to investigate how these expression patterns are established , we fused promoter regions of an acidic and a basic glucanase gene to the beta-glucuronidase ( GUS ) reporter gene and examined expression of these constructs in transgenic tobacco plants .","gene":["GUS","glucanase gene","beta-glucuronidase"],"gene_indices_start":[123,145,166],"gene_indices_end":[137,163,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5226,"text":"The results showed that IFN-gamma stimulated the rapid accumulation of interferon regulated factor ( IRF ) -1 mRNA , followed by a delayed and dose-dependent inhibition of alpha1 ( I ) procollagen mRNA expression in skin fibroblasts from several different donors .","gene":["alpha1 ( I ) procollagen mRNA","interferon regulated factor ( IRF ) -1 mRNA","IFN-gamma"],"gene_indices_start":[24,71,172],"gene_indices_end":[33,114,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5227,"text":"A split motor domain in a cytoplasmic dynein .","gene":["cytoplasmic dynein"],"gene_indices_start":[26],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5228,"text":"Effect of heparin on the inactivation of serum lipoprotein lipase by the liver in unanesthetized dogs .","gene":["serum lipoprotein lipase"],"gene_indices_start":[41],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5230,"text":"We then demonstrated that 1 ) GAL4-REV-erbA alpha chimeras that contain the 'AB' region and lack the 'E' region activated transcription of GAL4 response elements in the presence of 8-Br-cAMP and 2 ) the ligand-binding domain ( LBD ) contains an active transcriptional silencer .","gene":["'AB' region","GAL4-REV-erbA alpha chimeras","GAL4 response elements","'E' region"],"gene_indices_start":[30,76,101,139],"gene_indices_end":[58,87,111,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5231,"text":"When transfected into Drosophila SL-2 cells , pCAT plasmid containing 2 , 090 bp of 5'-flanking region shows a 3 . 0- to 3 . 5-fold increase in chloramphenicol acetyltransferase activity after induction with retinoic acid and \/ or 8-bromo-cAMP .","gene":["chloramphenicol acetyltransferase"],"gene_indices_start":[144],"gene_indices_end":[177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5232,"text":"In the course of screening for transcription factors which interact with the human myeloperoxidase ( MPO ) promoter we , for the first time , identified and cloned the cDNA and genomic DNA for human HBP1 ( HMG-Box containing protein 1 ) , a member of the high mobility group of non-histone chromosomal proteins .","gene":["MPO","high mobility group of non-histone chromosomal proteins","human myeloperoxidase","HMG-Box containing protein 1","human HBP1"],"gene_indices_start":[77,101,193,206,255],"gene_indices_end":[98,104,203,234,310],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5233,"text":"This analysis revealed that SAP 145 , together with four other SF3a \/ SF3b subunits , UV cross-links to pre-mRNA in a 20-nucleotide region upstream of the BPS .","gene":["BPS","SAP 145","SF3a \/ SF3b subunits"],"gene_indices_start":[28,63,155],"gene_indices_end":[35,83,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5234,"text":"The first contains ATF \/ CRE and TBP \/ TATA sequence motifs within an 87-bp region .","gene":["TBP","ATF","CRE"],"gene_indices_start":[19,25,33],"gene_indices_end":[22,28,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5236,"text":"The final predicted structure has an overall backbone deviation of 0 . 7 A from that of ras-p21 .","gene":["ras-p21"],"gene_indices_start":[88],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5239,"text":"Ten out of 10 patients with progressive disease had mast cells greater than or equal to 0 . 5% , hyaluronan greater than or equal to 50 micrograms . l-1 and fibronectin greater than or equal to 350 micrograms . l-1 compared to eight out of 41 patients with stable or regressive disease . ( ABSTRACT TRUNCATED AT 250 WORDS )","gene":["fibronectin"],"gene_indices_start":[157],"gene_indices_end":[168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5241,"text":"NSCL-1 is expressed in a larger number of these cell lines .","gene":["NSCL-1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5242,"text":"Both of these dogs had low serum IgG ( 3 . 5 to 7 . 2 mg \/ ml ) and the second littermate also had reduced serum IgA ( < 0 . 1 to 0 . 15 mg \/ ml ) .","gene":["IgA","IgG"],"gene_indices_start":[33,113],"gene_indices_end":[36,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5243,"text":"However , we did not observe a correlation between serum and seminal plasma PSA levels .","gene":["seminal plasma PSA"],"gene_indices_start":[61],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5244,"text":"Direct proof that the heightened renal cellular apoptosis in PKD is not occurring through p53 was obtained by successive matings between SBM and p53 ( - \/ - ) mice .","gene":["p53","p53"],"gene_indices_start":[90,145],"gene_indices_end":[93,148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5246,"text":"It has been demonstrated previously that Pax-6 , a paired domain ( PD ) \/ homeodomain ( HD ) transcription factor critical for eye development , contributes to the activation of the alphaB- , alphaA- , delta1- , and zeta-crystallin genes in the lens .","gene":["alphaB-","Pax-6","zeta-crystallin genes","paired domain ( PD ) \/ homeodomain ( HD ) transcription factor","delta1-","alphaA-"],"gene_indices_start":[41,51,182,192,202,216],"gene_indices_end":[46,113,189,199,209,237],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5250,"text":"Three ORFs ( 9765orfR002 , 9765orfR011 and 9765orfR013 ) were found to be homologous with Schizosaccharomyces pombe polyadenylate binding protein , Escherichia coli hypothetical 38 . 1-kDa protein in the BCR 5' region , and transcription regulatory protein Swi3 , respectively .","gene":["9765orfR011","9765orfR013","Swi3","BCR","polyadenylate binding protein","9765orfR002"],"gene_indices_start":[13,27,43,116,204,257],"gene_indices_end":[24,38,54,145,207,261],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5251,"text":"EBNA-2 and the cis-acting CD23 element increased TK-promoted mRNA and did not alter the herpes simplex virus TK promoter transcription start site .","gene":["herpes simplex virus TK promoter transcription start site","EBNA-2","CD23 element"],"gene_indices_start":[0,26,88],"gene_indices_end":[6,38,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5252,"text":"Analysis of ace2Delta cells reveals that Ace2p is required for cell separation but not for polarized growth .","gene":["Ace2p"],"gene_indices_start":[41],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5255,"text":"Phosphoamino acid analysis of radiolabeled ASGPR subunits identified Ser ( P ) as the predominant ( approximately 95% ) and Thr ( P ) as a minor ( approximately 5% ) phosphoamino acid in each polypeptide and confirmed the presence of Tyr ( P ) ( approximately 1% ) in RHL1 .","gene":["RHL1","ASGPR subunits"],"gene_indices_start":[43,268],"gene_indices_end":[57,272],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5261,"text":"In connective tissue , cell structure contributes to type I collagen expression .","gene":["type I collagen"],"gene_indices_start":[53],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5263,"text":"In this study , we have cloned the human DSG3 gene and examined the transcriptional regulation of its expression .","gene":["human DSG3 gene"],"gene_indices_start":[35],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5264,"text":"In simpler organisms , the ATP sulfurylase and APS kinase reactions are catalyzed by separate enzymes encoded by two or three genes , suggesting that a fusion of separate genes during the course of evolution generated the bifunctional enzyme .","gene":["ATP sulfurylase","APS kinase"],"gene_indices_start":[27,47],"gene_indices_end":[42,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5265,"text":"The protein predicted by the sequence of the human pim-1 proto-oncogene shares extensive homology with known serine \/ threonine protein kinases , and yet the human Pim-1 enzyme has previously been reported to exhibit protein tyrosine kinase activity both in vitro and in vivo .","gene":["serine \/ threonine protein kinases","human pim-1 proto-oncogene","protein tyrosine kinase","human Pim-1 enzyme"],"gene_indices_start":[45,109,158,217],"gene_indices_end":[71,143,176,240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5266,"text":"Compared to its counterpart in the GPB gene , exon 3 of the GPE gene contains several point mutations , an insertion of 24 bp , and a stop codon which shortens the reading frame .","gene":["GPE gene","GPB gene"],"gene_indices_start":[35,60],"gene_indices_end":[43,68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5267,"text":"Taken together , these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex .","gene":["Mif2 protein","Cep1p"],"gene_indices_start":[45,73],"gene_indices_end":[57,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5271,"text":"Induction of the CINC promoter by IL-17 in IEC-6 cells was TNF receptor-associated factor-6 ( TRAF6 ) , but not TRAF2 , dependent .","gene":["TRAF2","CINC promoter","TNF receptor-associated factor-6","TRAF6","IL-17"],"gene_indices_start":[17,34,59,94,112],"gene_indices_end":[30,39,91,99,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5272,"text":"This study reports the isolation of a P . hybrida gene , jaf13 , encoding a basic helix-loop-helix protein that , on the basis of sequence homology and intron \/ exon structure , represents the P . hybrida orthologue of the Z . mays r genes .","gene":["jaf13","Z . mays r genes","basic helix-loop-helix protein"],"gene_indices_start":[57,76,223],"gene_indices_end":[62,106,239],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5273,"text":"However , while IL-1beta and TNF-alpha both induced nuclear binding of the Rel proteins p50 and p65 to an NF-kappaB consensus oligonucleotide in gel shift assays and caused transient degradation of inhibitor of NF-kappaB-alpha ( IkappaB-alpha ) in the cytoplasm of myofibroblasts , only IL-1beta upregulated PDGF-Ralpha .","gene":["Rel proteins","p65","IkappaB-alpha","TNF-alpha","p50","NF-kappaB consensus oligonucleotide","PDGF-Ralpha","inhibitor of NF-kappaB-alpha","IL-1beta","IL-1beta"],"gene_indices_start":[16,29,75,88,96,106,198,229,287,308],"gene_indices_end":[24,38,87,91,99,141,226,242,295,319],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5275,"text":"The mRNA from this gene , termed HES1 , is ubiquitously expressed , but strongly so in heart and skeletal muscle .","gene":["HES1"],"gene_indices_start":[33],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5276,"text":"When ligated to the proIL-1 beta cap site-proximal region ( located between -131 to +12 ) , both the proIL-1 beta and the simian virus 40 enhancer elements functioned more efficiently in monocytes than in HeLa cells , which are not normally competent for IL-1 beta expression .","gene":["proIL-1 beta","simian virus 40 enhancer elements","IL-1 beta","proIL-1 beta cap site-proximal region"],"gene_indices_start":[20,101,122,255],"gene_indices_end":[57,113,155,264],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5277,"text":"Minor differences were noted with latamoxef producing mild persistant elevation of prothrombin time ( 0 . 7 second ) associated with depression of factor II and factor VII .","gene":["factor VII","prothrombin","factor II"],"gene_indices_start":[83,147,161],"gene_indices_end":[94,156,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5280,"text":"Levels of serum IgE were measured monthly , and nasal IgE was measured at the height and end of the season .","gene":["IgE","IgE"],"gene_indices_start":[16,54],"gene_indices_end":[19,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5281,"text":"PDGF A-chain levels increase in cultured vascular smooth muscle cells ( SMCs ) exposed to ATII .","gene":["ATII","PDGF A-chain"],"gene_indices_start":[0,90],"gene_indices_end":[12,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5284,"text":"HeLa and Jurkat cell lines carrying the nef gene linked to the CMV promoter or the HIV-1 LTR were isolated by coselection for neomycin resistance .","gene":["nef gene"],"gene_indices_start":[40],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5285,"text":"We have isolated and characterized the GCD6 and GCD7 genes and shown that their products are required to repress GCN4 translation under nonstarvation conditions .","gene":["GCD7 genes","GCN4","GCD6"],"gene_indices_start":[39,48,113],"gene_indices_end":[43,58,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5286,"text":"We have visualized DNA-protein complexes by electron microscopy and a high-affinity binding site of WDV Rep protein within the core element has been mapped to approximately 144 + \/ - 18 bp upstream from the initiation site , between the start site for complementary-sense transcription and the TATA box .","gene":["WDV Rep protein"],"gene_indices_start":[100],"gene_indices_end":[115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5287,"text":"Both in vitro-synthesized S2 protein and synthetic peptides corresponding to S2 are shown to react positively with sera obtained from EIAV-infected horses , providing the first direct evidence of expression of this protein in infected animals .","gene":["S2","S2 protein"],"gene_indices_start":[26,77],"gene_indices_end":[36,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5289,"text":"The number of bacteria in the lung , peripheral white blood cell and BAL fluid cell also decreased by the administration of FN .","gene":["FN"],"gene_indices_start":[124],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5290,"text":"A major mechanism by which estrogens prevent osteoporosis seems to be repression of transcription of NF-kappa B target genes , such as the osteoclast-activating cytokines interleukin-6 and interleukin-1 .","gene":["NF-kappa B target genes","interleukin-6","interleukin-1"],"gene_indices_start":[101,171,189],"gene_indices_end":[124,184,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5291,"text":"Suppressors of defective silencing in yeast : effects on transcriptional repression at the HMR locus , cell growth and telomere structure .","gene":["HMR locus"],"gene_indices_start":[91],"gene_indices_end":[100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5295,"text":"These findings indicate that hypergastrinemia induced by surgical removal of acid-producing mucosa in the rat has the same effects on oxyntical mucosal HDC activity , histamine concentration and ECL cell density as hypergastrinemia induced by continuous gastrin infusion or by long-term treatment with effective antisecretagogues .","gene":["mucosal HDC","gastrin"],"gene_indices_start":[144,254],"gene_indices_end":[155,261],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5296,"text":"We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences .","gene":["11-zinc-finger factor CTCF","human CTCF cDNA"],"gene_indices_start":[30,99],"gene_indices_end":[45,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5299,"text":"Nevertheless , protein kinase A stimulation induces CREMalpha to activate the complex native promoter in the phosphoenolpyruvate carboxykinase ( PEPCK ) gene .","gene":["PEPCK","CREMalpha","phosphoenolpyruvate carboxykinase","protein kinase A"],"gene_indices_start":[15,52,109,145],"gene_indices_end":[31,61,142,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5300,"text":"The calcitonin-induced tyrosine phosphorylation of HEF1 increased in a time- and dose-dependent manner .","gene":["HEF1"],"gene_indices_start":[51],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5301,"text":"These data locate the aniridia gene ( AN2 ) and a recurrent T-cell leukemia breakpoint ( TCL2 ) in the marker sequence , on opposite sides of MIC1 .","gene":["AN2","T-cell leukemia breakpoint","TCL2","MIC1","aniridia gene"],"gene_indices_start":[22,38,60,89,142],"gene_indices_end":[35,41,86,93,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5302,"text":"The p130 and p62 tyrosine-phosphorylated proteins that complexed v-Src SH2 in vitro also associated with v-Src in v-src-transformed Rat-2 cells ; this in vivo binding was dependent on the v-Src SH2 domain .","gene":["v-Src","p130","SH2","p62","v-Src","v-Src","SH2"],"gene_indices_start":[4,13,65,71,105,188,194],"gene_indices_end":[8,16,70,74,110,193,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5308,"text":"Myogenic differentiation can be inhibited by the adenovirus E1a protein in the rat L6 muscle cell line .","gene":["E1a protein"],"gene_indices_start":[60],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5312,"text":"Immunofixation experiments of C4A and C4B demonstrate > 41 allotypes in the two classes of proteins .","gene":["C4B","C4A"],"gene_indices_start":[30,38],"gene_indices_end":[33,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5314,"text":"Primer extension and cDNA cloning were used to isolate the complete 5' end of the Nramp1 mRNA .","gene":["Nramp1 mRNA"],"gene_indices_start":[82],"gene_indices_end":[93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5315,"text":"A 736-bp sequence of the 5' flanking region adjacent to the cap site of the human AFP gene shows a 61% similarity with the corresponding region of the mouse AFP gene .","gene":["mouse AFP gene","human AFP gene"],"gene_indices_start":[76,151],"gene_indices_end":[90,165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5317,"text":"The effect of site-specific mutations in the mouse platelet-derived growth factor ( PDGF ) beta-receptor on activation of the Na+ \/ H+ exchanger was examined in normal murine mammary gland epithelial ( NMuMG ) and Chinese hamster ovary ( CHO ) cells .","gene":["Na+ \/ H+ exchanger","mouse platelet-derived growth factor ( PDGF ) beta-receptor"],"gene_indices_start":[45,126],"gene_indices_end":[104,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5318,"text":"The Og4C3 enzyme-linked immunosorbent assay ( ELISA ) to detect circulating Wuchereria bancrofti antigen uses 50 microL of serum .","gene":["Wuchereria bancrofti antigen","Og4C3"],"gene_indices_start":[4,76],"gene_indices_end":[9,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5320,"text":"The inhibition of focus formation observed in the presence of C3G was not due to toxic effects on cell viability , since transfected C3G cells exhibited the same survival and growth rates as untransfected NIH3T3 cells or cells transfected with plasmid vector alone .","gene":["C3G","C3G"],"gene_indices_start":[62,133],"gene_indices_end":[65,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5321,"text":"In rubella patients with serologic confirmation by HI , the IF test detected significant rises in 219 ( 99 . 1% ) of 221 patients and the PHA test detected antibody conversion in 68 ( 93% ) of 73 patients .","gene":["PHA"],"gene_indices_start":[138],"gene_indices_end":[141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5322,"text":"Exposure of peripheral blood T cells from young subjects to PHA or cross-linked anti-CD3 monoclonal antibodies stimulated rapid increases in MAPK and MEK enzymatic activity .","gene":["MEK","MAPK","anti-CD3 monoclonal antibodies"],"gene_indices_start":[80,141,150],"gene_indices_end":[110,145,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5323,"text":"Southern blotting analysis implied the occurrence of multiple COXVb genes in the rat genome .","gene":["COXVb genes"],"gene_indices_start":[62],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5329,"text":"The contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre- and postsynaptic brain dopamine receptors , and an intervention of segregated basal ganglia-prefrontal cortex loops in motor and cognitive behaviour .","gene":["brain dopamine receptors"],"gene_indices_start":[196],"gene_indices_end":[220],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5330,"text":"As in Tb , U6 is a single-copy gene and two tRNA genes , tRNAGln and tRNAIle , are found upstream to the gene .","gene":["tRNA genes","U6","tRNAIle","tRNAGln"],"gene_indices_start":[11,44,57,69],"gene_indices_end":[13,54,64,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5331,"text":"Experimental adhesion prophylaxis with recombinant tissue plasminogen activator .","gene":["recombinant tissue plasminogen activator"],"gene_indices_start":[39],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5332,"text":"Thigh girth correlated positively with HDL and HDL2-C and mass , and with LDL particle size among women .","gene":["HDL","LDL","HDL2-C"],"gene_indices_start":[39,47,74],"gene_indices_end":[42,53,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5333,"text":"Cotransfection analyses of the T \/ EBP promoter-reporter constructs with a T \/ EBP expression vector into human HepG2 cells , which do not express T \/ EBP , suggested that autoregulation may be involved in controlling both rat and human T \/ EBP gene expression .","gene":["human T \/ EBP gene","T \/ EBP","T \/ EBP","T \/ EBP promoter-reporter constructs"],"gene_indices_start":[31,75,147,231],"gene_indices_end":[67,82,154,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5335,"text":"Previous studies indicated that the 20S proteasome is a catalytic core of the 26S proteolytic complex that possesses a latent multicatalytic proteinase activity and catalyzes an ATP-dependent , selective breakdown of proteins ligated to ubiquitin .","gene":["20S proteasome","proteinase","ubiquitin","26S proteolytic complex"],"gene_indices_start":[36,78,141,237],"gene_indices_end":[50,101,151,246],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5336,"text":"The fission yeast dsk1+ gene , a multicopy suppressor for cold-sensitive dis1 mutants , encodes a novel 61-kd protein kinase .","gene":["61-kd protein kinase","dis1 mutants","fission yeast dsk1+ gene"],"gene_indices_start":[4,73,104],"gene_indices_end":[28,85,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5342,"text":"Sterol analysis of the disrupted mutant demonstrated the accumulation of ignosterol , indicating a loss of Erg24p activity .","gene":["Erg24p"],"gene_indices_start":[107],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5343,"text":"However , tyrA can be expressed efficiently from an internal promoter which appears to lie within the 3' portion of aroF .","gene":["aroF","tyrA"],"gene_indices_start":[10,116],"gene_indices_end":[14,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5346,"text":"Urinary N-acetylglucosaminidase activity per mg creatinine did not differ significantly between groups .","gene":["Urinary N-acetylglucosaminidase"],"gene_indices_start":[0],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5348,"text":"Ritanserin is a new substance with highly selective blocking activity on S2 receptors for 5-HT in the central nervous system .","gene":["S2 receptors"],"gene_indices_start":[73],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5354,"text":"By using the full-length cytoplasmic domain and mutants with progressive carboxy-terminal deletions , internal deletions , or point mutations , we identified the first 150 amino acid residues of LIFR as the minimal region necessary for signaling .","gene":["LIFR"],"gene_indices_start":[195],"gene_indices_end":[199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5355,"text":"In the predicted transmembrane domain , Casr-rs2 and Casr-rs3 are 95% identical to Casr-rs1 .","gene":["Casr-rs1","Casr-rs3","Casr-rs2"],"gene_indices_start":[40,53,83],"gene_indices_end":[48,61,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5358,"text":"In order to overcome the false positive readings that are possible in sphincter manometry , we proposed to use secretin stimulated endoscopic ultrasound ( SSEUS ) to measure pancreatic ductal response as an adjunctive method to aid and supplement the diagnosis .","gene":["secretin"],"gene_indices_start":[111],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5359,"text":"CES4 on a multicopy plasmid was unable to suppress tif1-A79V .","gene":["tif1-A79V","CES4"],"gene_indices_start":[0,51],"gene_indices_end":[4,60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5362,"text":"We report here the isolation of a full-length cDNA clone coding for a hitherto undiscovered isoform of the bovine C-subunit .","gene":["bovine C-subunit"],"gene_indices_start":[107],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5368,"text":"A cDNA encoding the amino-terminal 17% of apoB ( apoB17 ) was fused to a cDNA coding for the last 37 amino acids of decay-accelerating factor ( DAF ) , which contains the signal for glycosylphosphatidylinositol anchor attachment .","gene":["DAF","decay-accelerating factor","apoB","apoB17"],"gene_indices_start":[42,49,116,144],"gene_indices_end":[46,55,141,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5372,"text":"Comparison with the sequence databanks show that Tactile is a member of the immunoglobulin gene superfamily , with similarity to Drosophila amalgam , the melanoma Ag MUC-18 , members of the carcinoembryonic Ag family , the poliovirus receptor , and the neural cell adhesion molecule .","gene":["Drosophila amalgam","poliovirus receptor","carcinoembryonic Ag family","melanoma Ag MUC-18","immunoglobulin gene superfamily","neural cell adhesion molecule","Tactile"],"gene_indices_start":[49,76,129,154,190,223,253],"gene_indices_end":[56,107,147,172,216,242,282],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5374,"text":"Mnt : Max complexes also efficiently suppress Myc-dependent activation from the same promoter .","gene":["Mnt : Max complexes"],"gene_indices_start":[0],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5376,"text":"Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites .","gene":["Nramp gene"],"gene_indices_start":[53],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5377,"text":"Because RNase III host mutants are defective in sib regulation , processing of the PL mRNA at sib by this endoribonuclease may cause int mRNA decay and decrease int synthesis .","gene":["sib","RNase III host mutants","endoribonuclease","int mRNA","PL mRNA","sib","int"],"gene_indices_start":[8,48,83,94,106,133,161],"gene_indices_end":[30,51,90,97,122,141,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5380,"text":"A genetic complementation system was developed in which tobacco etch virus ( TEV ) polymerase ( NIb ) -expressing transgenic plants or protoplasts were inoculated with NIb-defective TEV mutants .","gene":["tobacco etch virus ( TEV ) polymerase","TEV mutants","NIb"],"gene_indices_start":[56,96,182],"gene_indices_end":[93,99,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5381,"text":"Furthermore , as in the human gene , the 3' end of the Cacna1f gene maps within 5 kb of the 5' end of the mouse synaptophysin gene in a region orthologous to Xp11 . 23 .","gene":["mouse synaptophysin gene","Cacna1f gene"],"gene_indices_start":[55,106],"gene_indices_end":[67,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5382,"text":"The following evidence indicates that the 69-kD protein is a common , rather than a U1-specific , protein , possibly associating with the snRNP core particles by protein-protein interaction .","gene":["snRNP core particles"],"gene_indices_start":[138],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5384,"text":"In this study , we demonstrate that BOX DNA enhances transcription from the thymidine kinase ( TK ) promoter in various EC cells .","gene":["thymidine kinase","TK","BOX DNA"],"gene_indices_start":[36,76,95],"gene_indices_end":[43,92,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5386,"text":"We show here that the third SH3 domain binds to Sos , a guanine nucleotide exchange factor for Ras and Rac , both in vitro and in vivo .","gene":["Ras","guanine nucleotide exchange factor","SH3 domain","Sos","Rac"],"gene_indices_start":[28,48,56,95,103],"gene_indices_end":[38,51,90,98,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5387,"text":"Its predicted amino acid sequence shows extensive homology to those of Drosophila hsp70 , trout hsp70 , Xenopus hsp70 , yeast hsp70 , and some homology to the heat-inducible dnaK gene product of Escherichia coli .","gene":["Drosophila hsp70","trout hsp70","heat-inducible dnaK gene product","Xenopus hsp70","yeast hsp70"],"gene_indices_start":[71,90,104,120,159],"gene_indices_end":[87,101,117,131,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5389,"text":"SH2D1A protein levels are up-regulated by CD40 cross-linking and down-regulated by B cell receptor ligation .","gene":["B cell receptor","SH2D1A protein","CD40"],"gene_indices_start":[0,42,83],"gene_indices_end":[14,46,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5391,"text":"A partial cDNA sequence indicated that the T lymphocyte early-activation gene ( Tea ) encodes a protein related to the dual-function ecotropic retrovirus receptor \/ cationic amino acid transporter ( ecoR \/ CAT1 ) , and RNA blots suggested highest Tea expression in T lymphocytes and liver ( MacLeod , C . L . , Finley , K . , Kakuda , D .","gene":["T lymphocyte early-activation gene","ecotropic retrovirus receptor \/ cationic amino acid transporter","Tea","ecoR \/ CAT1","Tea"],"gene_indices_start":[43,80,133,199,247],"gene_indices_end":[77,83,196,210,250],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5394,"text":"UbiA is also unique among known polyubiquitin genes in containing four cis-spliced introns within its coding sequence .","gene":["polyubiquitin genes","UbiA"],"gene_indices_start":[0,32],"gene_indices_end":[4,51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5395,"text":"Stress-inducible protein kinases capable of activating c-jun expression include stress-activated protein kinase \/ c-Jun N-terminal protein kinase ( SAPK \/ JNK ) and p38 members of the mitogen-activated protein kinase ( MAPK ) superfamily of signaling molecules .","gene":["Stress-inducible protein kinases","stress-activated protein kinase","c-Jun N-terminal protein kinase","MAPK","c-jun","SAP","JNK","p38","mitogen-activated protein kinase"],"gene_indices_start":[0,55,80,114,148,155,165,184,219],"gene_indices_end":[32,60,111,145,152,158,168,216,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5396,"text":"The variable regions of vertebrate striated TnT isoforms reflect the subsequent addition and modification of genomic sequences to give rise to members of the TnT multigene family .","gene":["TnT multigene family","TnT isoforms"],"gene_indices_start":[44,158],"gene_indices_end":[56,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5398,"text":"Alternative splicing of the cytoplasmic tail appears to generate multiple PECAM-1 isoforms that may regulate phosphorylation , cytoskeletal association , and affinity modulation of the mature protein .","gene":["PECAM-1 isoforms"],"gene_indices_start":[74],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5400,"text":"Here , we have used specific antibody to identify and characterize the SSN6 protein .","gene":["SSN6 protein"],"gene_indices_start":[71],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5401,"text":"Many mammary tumors induced by mouse mammary tumor virus ( MMTV ) contain a provirus in the same region of the host-cell genome , leading to expression of a putative cellular oncogene called int-1 .","gene":["int-1"],"gene_indices_start":[191],"gene_indices_end":[196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5402,"text":"Bifunctionality of the AcMNPV homologous region sequence ( hr1 ) : enhancer and ori functions have different sequence requirements .","gene":["AcMNPV homologous region sequence","hr1"],"gene_indices_start":[23,59],"gene_indices_end":[56,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5404,"text":"In XO males , two her-1 mRNAs , her-1a and her-1b , are transcribed from two separate promoters : P1 , located in the 5'-flanking region , and P2 , located in the large second intron .","gene":["her-1 mRNAs","her-1b","her-1a"],"gene_indices_start":[18,32,43],"gene_indices_end":[29,38,49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5406,"text":"The human CD38 gene consists of 8 exons that extend more than 77 kb on the human genome .","gene":["human CD38 gene"],"gene_indices_start":[4],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5407,"text":"MED1 has a weak glycosylase activity on the mutagenic adduct 3 , N ( 4 ) -ethenocytosine , a metabolite of vinyl chloride and ethyl carbamate .","gene":["MED1","glycosylase"],"gene_indices_start":[0,16],"gene_indices_end":[4,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5408,"text":"Screening of asthma patients by determination of IgE and by comprehension of spectrum of allergospecific IgE antibodies .","gene":["allergospecific IgE antibodies","IgE"],"gene_indices_start":[49,89],"gene_indices_end":[52,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5410,"text":"PABP is a modular protein , with four N-terminal RNA-binding domains and an extensive C terminus .","gene":["PABP"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5411,"text":"Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell phenotypes in the anterior pituitary gland .","gene":["POU domain factor","Pit-1"],"gene_indices_start":[0,27],"gene_indices_end":[5,44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5412,"text":"Deletion of an intergenic DNA-binding site for this complex from a human beta-globin locus construct results in delayed human gamma- to beta-globin switching in transgenic mice , suggesting that the PYR complex acts to facilitate the switch .","gene":["human gamma-","human beta-globin locus construct","beta-globin","PYR complex"],"gene_indices_start":[67,120,136,199],"gene_indices_end":[100,132,147,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5413,"text":"Proteins immunoprecipitated from lysates of control- and VEGF-stimulated BAEC with antisera to phospholipase C-gamma ( PLC-gamma ) were fractionated by SDS-polyacrylamide gel electrophoresis and transferred to Immobilon-P .","gene":["phospholipase C-gamma","PLC-gamma"],"gene_indices_start":[95,119],"gene_indices_end":[116,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5415,"text":"These data suggest that other Ras effectors can collaborate with PI 3-kinase and with each other to activate Pak .","gene":["PI 3-kinase","Pak","Ras effectors"],"gene_indices_start":[30,65,109],"gene_indices_end":[43,76,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5421,"text":"Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene .","gene":["human beta 3 integrin gene"],"gene_indices_start":[63],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5422,"text":"OBJECTIVE : To demonstrate a lack of effect of steady-state concentrations of cilomilast , a new oral phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease , on warfarin-induced anticoagulation .","gene":["phosphodiesterase 4"],"gene_indices_start":[102],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5425,"text":"Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice .","gene":["serotonin receptor"],"gene_indices_start":[39],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5426,"text":"Regulation of avian fibroblast growth factor receptor 1 ( FGFR-1 ) gene expression during skeletal muscle differentiation .","gene":["FGFR-1","avian fibroblast growth factor receptor 1"],"gene_indices_start":[14,58],"gene_indices_end":[55,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5428,"text":"To confirm the binding of protein to these sites in cells , we carried out an in vivo genomic footprinting analysis of this portion of the TGF alpha promoter in normal and transformed rat liver epithelial cell lines that express the endogenous gene at varying levels .","gene":["TGF alpha promoter"],"gene_indices_start":[139],"gene_indices_end":[157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5435,"text":"In the present study , we show that SRm160 \/ 300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene .","gene":["SRm160 \/ 300","Drosophila doublesex gene","ESE"],"gene_indices_start":[36,79,138],"gene_indices_end":[48,82,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5436,"text":"In addition , we have isolated a genomic fragment containing the most distal 5' sequences of the major GGT mRNA in HepG2 cells .","gene":["GGT mRNA"],"gene_indices_start":[103],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5437,"text":"The seventh cysteine residue of CTSE is located within the activation peptide region of the proenzyme .","gene":["CTSE"],"gene_indices_start":[32],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5439,"text":"To determine the signal recognition particle ( SRP ) -SRP receptor ( Srb ) system in Bacillus subtilis ( Bs ) , we cloned the Bs srb gene , which encodes a homologue of the mammalian SRP receptor alpha-subunit [ Oguro et al . , DNA Res .","gene":["signal recognition particle ( SRP ) -SRP receptor ( Srb ) system in Bacillus subtilis ( Bs )","Bs srb gene","mammalian SRP receptor alpha-subunit"],"gene_indices_start":[17,126,173],"gene_indices_end":[109,137,209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5440,"text":"TREB7 and TREB36 protected all three repeats of the 21 bp , but TREB5 protected only the second repeat .","gene":["TREB36","TREB5","TREB7"],"gene_indices_start":[0,10,64],"gene_indices_end":[5,16,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5443,"text":"The carboxyl-terminal CCCC module is structurally related to the DNA-binding domain of the erythroid transcription factor GATA-1 .","gene":["erythroid transcription factor GATA-1","carboxyl-terminal CCCC module"],"gene_indices_start":[4,91],"gene_indices_end":[33,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5445,"text":"The novel approach to insulin administration known as chronic intermittent intravenous insulin therapy ( CIIIT ) delivers insulin in a pulsatile fashion and achieves physiological insulin concentration in the portal vein .","gene":["insulin","insulin","insulin","insulin"],"gene_indices_start":[22,87,122,180],"gene_indices_end":[29,94,129,187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5446,"text":"The kallistatin gene was localized by in situ hybridization to human chromosome 14q31-q32 . 1 , close to the serpin genes encoding alpha 1-antichymotrypsin , protein C inhibitor , alpha 1-antitrypsin , and corticosteroid-binding globulin .","gene":["serpin genes","corticosteroid-binding globulin","kallistatin gene","alpha 1-antichymotrypsin","alpha 1-antitrypsin","protein C inhibitor"],"gene_indices_start":[4,109,131,158,180,206],"gene_indices_end":[20,121,155,177,199,237],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5447,"text":"The shift to the nonpermissive temperature is accompanied by the loss of guanyl nucleotide-dependent activity of adenylylcyclase in vitro .","gene":["adenylylcyclase"],"gene_indices_start":[113],"gene_indices_end":[128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5448,"text":"In vitro translation of the mTRF1 cDNA resulted in a 56 kDa protein that binds to TTAGGG repeat arrays . mTRF1 displayed the same sequence specificity as hTRF1 , preferring arrays of TTAGGG repeats as a binding substrate over TTAGGC and TTGGGG repeats .","gene":["TTAGGG repeat","TTAGGG repeats","TTGGGG repeats","hTRF1","TTAGGC","mTRF1 cDNA","mTRF1"],"gene_indices_start":[28,82,105,154,183,226,237],"gene_indices_end":[38,95,110,159,197,232,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5450,"text":"From these results , we concluded that this ORF is the FRDS gene .","gene":["FRDS gene"],"gene_indices_start":[55],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5452,"text":"Intron-exon structure of the porcine I kappa B alpha-encoding gene .","gene":["porcine I kappa B alpha-encoding gene"],"gene_indices_start":[29],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5453,"text":"Interleukin-6 ( IL-6 ) is a pleiotropic cytokine , which is involved in inflammatory and immune responses , acute phase reactions , and hematopoiesis .","gene":["Interleukin-6","IL-6"],"gene_indices_start":[0,16],"gene_indices_end":[13,20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5458,"text":"We report the identification and characterization of myr 4 ( myosin from rat ) , the first mammalian myosin I that is not closely related to brush border myosin I .","gene":["mammalian myosin I","myosin I","myr 4","myosin from rat"],"gene_indices_start":[53,61,91,154],"gene_indices_end":[58,76,109,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5460,"text":"The time course of RNA1 replication and RNA3 synthesis in induced yeast paralleled that in yeast transfected with natural FHV virion RNA .","gene":["RNA3","RNA1"],"gene_indices_start":[19,40],"gene_indices_end":[23,44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5461,"text":"The relevance of these elements in conferring anaerobic induction of gpc4 gene expression is discussed .","gene":["gpc4 gene"],"gene_indices_start":[69],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5462,"text":"The genomic structure and chromosomal location of the human TR2 orphan receptor , a member of the steroid receptor superfamily .","gene":["human TR2 orphan receptor","steroid receptor superfamily"],"gene_indices_start":[54,98],"gene_indices_end":[79,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5463,"text":"We identify considerable spatio-temporal similarities between reported expression patterns of Ypr10 genes and ribonuclease genes , which , together with the significant sequence similarity to the ginseng ribonuclease , support the hypothesis of a ribonuclease function for PR-10 proteins and allow the prediction of possible biological roles .","gene":["PR-10 proteins","ribonuclease genes","ginseng ribonuclease","ribonuclease","Ypr10 genes"],"gene_indices_start":[94,110,196,247,273],"gene_indices_end":[105,128,216,259,287],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5464,"text":"The p20-CGGBP gene is conserved among mammals but shows no homology to non-vertebrate species .","gene":["p20-CGGBP gene"],"gene_indices_start":[4],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5466,"text":"The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non-coronarogenic myocardial diseases .","gene":["creatine phosphokinase"],"gene_indices_start":[31],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5468,"text":"When the blood clot is formed in the vitreous cavity , intravitreal injection of t-PA can convert plasminogen to plasmin and remove the clot .","gene":["t-PA","plasminogen"],"gene_indices_start":[81,98],"gene_indices_end":[85,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5471,"text":"The distinguishing features involved eight amino acid changes , including a single lysine deletion relative to a primate consensus sequence in the first complementary-determing region of V1J1 .","gene":["V1J1"],"gene_indices_start":[187],"gene_indices_end":[191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5472,"text":"We cloned a complete cDNA ( 2 . 9 kb ) for HET from an MCF-7 cDNA library .","gene":["HET"],"gene_indices_start":[43],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5473,"text":"NF-kappaB is a redox-sensitive transcription factor known to be activated by oxidative stress as well as chemical and biological reductants .","gene":["NF-kappaB"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5477,"text":"The primary pancreatic insult seemed to be unaffected by the treatment , because neither the rise in plasma lipase nor the development of ascites or the extension of the pancreatic necrosis were diminished .","gene":["plasma lipase"],"gene_indices_start":[101],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5478,"text":"Detailed analysis of alpha1 , 3GT transcripts revealed two major alternative splicing patterns in the 5'-untranslated region ( 5'-UTR ) and evidence for minor splicing activity that occurs in a tissue-specific manner .","gene":["alpha1 , 3GT transcripts"],"gene_indices_start":[21],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5479,"text":"The segmental and regional projections of the sciatic , tibial and common peroneal nerves to the substantia gelatinosa of the spinal cord in rats--an experimental study by means of an acid phosphatase ( ACP ) method .","gene":["acid phosphatase","ACP"],"gene_indices_start":[184,203],"gene_indices_end":[200,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5480,"text":"Angiotensin converting enzyme inhibitors enhance the antihypertensive efficacy of diuretics and blunt or prevent adverse metabolic effects .","gene":["Angiotensin converting enzyme"],"gene_indices_start":[0],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5481,"text":"Two closely related variants of Stat5 , Stat5a and Stat5b , are encoded by distinct genes .","gene":["Stat5b","Stat5a","Stat5"],"gene_indices_start":[32,40,51],"gene_indices_end":[37,46,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5482,"text":"Also , small , sense and antisense approximately 22 nt RNAs , derived from the satRNA , were associated with the replicating satellite .","gene":["satRNA"],"gene_indices_start":[79],"gene_indices_end":[85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5486,"text":"Regulation of myosin phosphatase activity involves changes in subunit interactions , although molecular mechanisms are not defined .","gene":["myosin phosphatase"],"gene_indices_start":[14],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5487,"text":"However , the history of acute severe complications from otitis media revealed a higher frequency in those individuals with alpha 1-antitrypsin deficiency as compared to normals .","gene":["alpha 1-antitrypsin"],"gene_indices_start":[124],"gene_indices_end":[143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5488,"text":"Unlike P135gag-myb-ets and the Mr 75 , 000 translation product of c-myb ( P75c-myb ) , which are nuclear proteins , P54c-ets was found to be predominantly cytoplasmic .","gene":["P75c-myb","P54c-ets","c-myb","P135gag-myb-ets"],"gene_indices_start":[7,66,74,116],"gene_indices_end":[22,71,82,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5490,"text":"We now describe a second RIM protein , called RIM2 , that is highly homologous to RIM1 and also expressed primarily in brain .","gene":["RIM protein","RIM2","RIM1"],"gene_indices_start":[25,46,82],"gene_indices_end":[36,50,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5491,"text":"The priming activity of DNA incised by either of the Drosophila enzymes can be enhanced , however , by an additional incubation with E . coli endonuclease IV , which is known to cleave depurinated DNA on the 5'-side of an apurinic site .","gene":["E . coli endonuclease IV"],"gene_indices_start":[133],"gene_indices_end":[157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5493,"text":"To assess the functional importance of these NBS in the overall drug resistance phenotype conferred by mdr1 , we introduced amino acid substitutions in the core consensus sequence for nucleotide binding , GXGKST .","gene":["mdr1","GXGKST"],"gene_indices_start":[103,205],"gene_indices_end":[107,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5494,"text":"Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene : mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences .","gene":["Saccharomyces cerevisiae MFA2 gene","rad16"],"gene_indices_start":[54,202],"gene_indices_end":[88,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5496,"text":"Behavior of aspartate aminotransferase ( EC 2 . 6 . 1 . 1 ) and alanine aminotransferase ( EC 2 . 6 . 1 . 2 ) in rat serum during the course of acute radiation syndrome following whole body X-irradiation .","gene":["alanine aminotransferase","aspartate aminotransferase","EC 2 . 6 . 1 . 2","EC 2 . 6 . 1 . 1"],"gene_indices_start":[12,41,64,91],"gene_indices_end":[38,57,88,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5497,"text":"NUP145 was previously identified by using a genetic synthetic lethal screen ( E .","gene":["NUP145"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5500,"text":"TPBF has two potential coiled-coil regions , a basic region , a proline-rich region , a histidine-rich N terminus , and a nuclear targeting sequence .","gene":["TPBF"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5503,"text":"Identity elements in tRNA for mono- and dimethylation reactions by the recombinant pfTrm1p were identified using in vitro T7 transcripts of 33 variants of tRNA ( Asp ) and tRNA ( Phe ) from yeast .","gene":["tRNA ( Asp ) and tRNA ( Phe ) from yeast","tRNA","recombinant pfTrm1p"],"gene_indices_start":[21,71,155],"gene_indices_end":[25,90,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5505,"text":"This E box sequence ( CACGTG ) is identical to the binding element for USF ( upstream stimulatory factor ) , a member of the helix-loop-helix family of transcription factors .","gene":["USF","helix-loop-helix family of transcription factors","E box sequence ( CACGTG )","upstream stimulatory factor"],"gene_indices_start":[5,71,77,125],"gene_indices_end":[30,74,104,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5506,"text":"We have demonstrated previously that two binding sites in the -184 HNF-3 beta promoter are recognized by widely distributed factors and that there is also a critical autoregulatory site , we identified a binding site for a cell-specific factor , LF-H3 beta , that may function in restricting HNF-3 beta gene expression to hepatocytes .","gene":["HNF-3 beta gene","LF-H3 beta","-184 HNF-3 beta promoter"],"gene_indices_start":[62,246,292],"gene_indices_end":[86,256,307],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5507,"text":"Overlapping clones representing full-length cDNAs for MMI alpha were obtained from mouse brain .","gene":["MMI alpha"],"gene_indices_start":[54],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5509,"text":"Chagas' disease , visceral leishmaniasis , anti-nuclear factor , schistosomiasis , rheumatoid factor and normal controls .","gene":["anti-nuclear factor","rheumatoid factor"],"gene_indices_start":[43,83],"gene_indices_end":[62,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5510,"text":"MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 .","gene":["MZF-1","CAT reporter gene","GAL4 binding sites"],"gene_indices_start":[0,16,49],"gene_indices_end":[5,33,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5511,"text":"The bcl-2 gene can potentially encode 26- and 22-kDa proteins that differ only in their carboxyl tails because of an alternative splicing mechanism .","gene":["bcl-2 gene"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5512,"text":"We have identified a strong Tas-responsive element , designated TRE ( GP ) , near the 3' end of the gag gene and preceding the pol gene of SFV-1 .","gene":["Tas-responsive element","pol gene","gag gene","TRE","GP"],"gene_indices_start":[28,64,70,100,127],"gene_indices_end":[50,67,72,108,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5513,"text":"In gel mobility shift assays , factors present in nuclear extracts derived from differentiated osteoblast bound to oligonucleotide probes containing the E-box 1 and E-box 2 elements .","gene":["E-box 2 elements","E-box 1"],"gene_indices_start":[153,165],"gene_indices_end":[160,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5514,"text":"Induction of proto-oncogene fos transcription through the adenylate cyclase pathway : characterization of a cAMP-responsive element .","gene":["adenylate cyclase pathway","cAMP-responsive element","proto-oncogene fos"],"gene_indices_start":[13,58,108],"gene_indices_end":[31,83,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5516,"text":"We conclude that common upstream signals cause activation of Ras and TC21 , but activated TC21 controls cell growth via distinct Raf-independent downstream signaling pathways .","gene":["TC21","Ras","TC21"],"gene_indices_start":[61,69,90],"gene_indices_end":[64,73,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5517,"text":"Our experiments suggest that the SCL gene can be a target for the erythroid transcription factor GATA-1 and that the SCL gene product serves as a positive regulator of erythroid differentiation .","gene":["erythroid transcription factor GATA-1","SCL gene","SCL gene product"],"gene_indices_start":[33,66,117],"gene_indices_end":[41,103,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5519,"text":"These results indicate that Rb protein is interacting with some component ( s ) of the cell cycle-regulatory machinery during G2 phase .","gene":["Rb protein"],"gene_indices_start":[28],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5520,"text":"A small amount of HSP81-1 mRNA was detected only in roots .","gene":["HSP81-1 mRNA"],"gene_indices_start":[18],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5521,"text":"The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter .","gene":["human megasatellite tandem repetitive sequence","RS447"],"gene_indices_start":[4,10],"gene_indices_end":[9,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5522,"text":"There was no correlation between secretor status and clinical status , spirometry measurements , salivary and serum lysozyme levels or rates of respiratory tract colonization with P . aeruginosa and S . aureus .","gene":["serum lysozyme"],"gene_indices_start":[110],"gene_indices_end":[124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5524,"text":"We sought to determine whether such differences in polyadenylation affect the steady-state levels of DHFR and mRNAs expressed from either allele and , in a more general sense , to ask whether differences in 3' end RNA processing in a gene containing multiple poly ( A ) sites affects the final level of gene expression .","gene":["DHFR"],"gene_indices_start":[101],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5526,"text":"ACTH release is transiently suppressed in some children after exogenous ACTH treatment .","gene":["ACTH","ACTH"],"gene_indices_start":[0,72],"gene_indices_end":[4,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5527,"text":"In the cell-free import assay , beta-catenin rapidly migrates into the nucleus without the exogenous addition of cytosol , Ran , or ATP \/ GTP .","gene":["Ran","beta-catenin"],"gene_indices_start":[32,123],"gene_indices_end":[44,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5529,"text":"Inverse relation between serum IgG concentration and glucose and xylose absorption in Zambian African adults .","gene":["IgG"],"gene_indices_start":[31],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5530,"text":"Moreover , glucan synthase activity , which is activated by Rho1p , was significantly reduced in the deltabem4 mutant .","gene":["glucan synthase","Rho1p","deltabem4 mutant"],"gene_indices_start":[11,60,101],"gene_indices_end":[26,65,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5533,"text":"METHODS : Von Willebrand factor ( vWF ) and the fibrinolytic factors tissue plasminogen activator ( tPA ) , measured as tPA capacity , and plasminogen activator inhibitor 1 ( PAI-1 ) , platelets , fibrinogen , and inflammatory markers were measured in 74 patients with active seropositive RA .","gene":["tissue plasminogen activator","tPA","plasminogen activator inhibitor 1","PAI-1","Von Willebrand factor","fibrinogen","tPA","vWF"],"gene_indices_start":[10,34,69,100,120,139,175,197],"gene_indices_end":[31,37,97,103,123,172,180,207],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5535,"text":"Prevention by a heparin-antithrombin III combination .","gene":["heparin-antithrombin III"],"gene_indices_start":[16],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5536,"text":"Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates .","gene":["dopamine transporters"],"gene_indices_start":[46],"gene_indices_end":[67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5537,"text":"Several cDNAs corresponding to the human PWP2 gene were identified and partially sequenced .","gene":["human PWP2 gene"],"gene_indices_start":[35],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5538,"text":"The primary structure and cotranscription of the petCA genes encoding the Rieske-FeS ( nuclear encoded in plants ) and apocytochrome f proteins has been described previously ( Kallas , T . , Spiller , S . , and Malkin , R .","gene":["nuclear encoded in plants","apocytochrome f proteins","Rieske-FeS","petCA genes"],"gene_indices_start":[49,74,87,119],"gene_indices_end":[60,84,112,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5540,"text":"Pregnant women at term had the lowest levels of antithrombin III .","gene":["antithrombin III"],"gene_indices_start":[48],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5542,"text":"Sequence analysis revealed significant differences between the 5' region of the beta subunit gene and the corresponding regions of the homologous GlyR alpha subunit genes ; it also identified a novel exon ( exon 0 ) that encodes most of the 5'-untranslated portion of the GlyR beta mRNA .","gene":["beta subunit gene","homologous GlyR alpha subunit genes","GlyR beta mRNA"],"gene_indices_start":[80,135,272],"gene_indices_end":[97,170,286],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5543,"text":"A study in vivo of adrenergic receptors in the rectum and in the internal and sphincter of the cat .","gene":["adrenergic receptors"],"gene_indices_start":[19],"gene_indices_end":[39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5545,"text":"The resulting mutants were coexpressed with gE in the vaccinia virus-based vTF7-3 system , and the formation and endoplasmic reticulum ( ER ) -to-Golgi transport of the hetero-oligomeric complex were monitored .","gene":["gE"],"gene_indices_start":[44],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5546,"text":"Molecular dissection of the multimeric CD3-TCR complex revealed that at least two associated polypeptides , CD3 zeta and CD3 epsilon , autonomously couple antigenic recognition event to early and late events of the intracytoplasmic activation cascade .","gene":["CD3 epsilon","multimeric CD3-TCR complex","CD3 zeta"],"gene_indices_start":[28,108,121],"gene_indices_end":[54,116,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5547,"text":"Comparison with alkaline phosphatases and 5-nucleotidase .","gene":["alkaline phosphatases","5-nucleotidase"],"gene_indices_start":[16,42],"gene_indices_end":[37,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5548,"text":"The GAC1 gene encodes the regulatory subunit for a type 1 serine \/ threonine phosphoprotein phosphatase , Glc7 .","gene":["GAC1 gene","Glc7","type 1 serine \/ threonine phosphoprotein phosphatase"],"gene_indices_start":[4,51,106],"gene_indices_end":[13,103,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5549,"text":"These results are consistent with the roles that CCK and trypsin inhibitors are believed to play in the negative feedback control of pancreatic exocrine function .","gene":["CCK","trypsin"],"gene_indices_start":[49,57],"gene_indices_end":[52,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5552,"text":"These findings indicate that the t ( 4 ; 14 ) ( p16 . 3 ; q32 ) represents a novel , recurrent chromosomal translocation in MM , and suggest that the FGFR3 gene may be the target of this abnormality and thus contribute to tumorigenesis in MM .","gene":["FGFR3 gene"],"gene_indices_start":[150],"gene_indices_end":[160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5554,"text":"Stringent hybridization of EHS-1 back to primate genomic DNA indicates two distinct EHS-1 loci in normal human DNA , an identical band pattern in chimpanzee DNA , and a single locus in rhesus monkey DNA .","gene":["EHS-1","EHS-1 loci"],"gene_indices_start":[27,84],"gene_indices_end":[32,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5557,"text":"Twenty eligible patients with cirrhosis were randomized into two groups : 10 patients treated with 6 million units of natural IFN-beta twice a week for 36 months and 10 patients without IFN therapy .","gene":["IFN","IFN-beta"],"gene_indices_start":[126,186],"gene_indices_end":[134,189],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5558,"text":"The multidomain structure includes a cysteine-rich motif resembling those of protein kinase C and n-chimaerin and a putative pleckstrin homology domain .","gene":["protein kinase C","n-chimaerin","pleckstrin homology domain"],"gene_indices_start":[77,98,125],"gene_indices_end":[93,109,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5560,"text":"Method of synthesis of the rheumatoid factor in clinico-immunological studies .","gene":["rheumatoid factor"],"gene_indices_start":[27],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5563,"text":"Expression plasmids harboring full-length or kinase domain of PKC alpha and PKC delta ( PKC alpha K and PKC delta K ) were constructed .","gene":["PKC delta K","PKC alpha K","PKC alpha","PKC delta"],"gene_indices_start":[62,76,88,104],"gene_indices_end":[71,85,99,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5565,"text":"The asymmetric methylation was associated with tissue-specific disruption of H19 genomic imprinting in fetal brain .","gene":["H19"],"gene_indices_start":[77],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5568,"text":"A poor correlation was also observed between PbB and ALAD activity of the stearate workers .","gene":["ALAD"],"gene_indices_start":[53],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5569,"text":"Analysis of several Tat mutants indicated that both the cysteine-rich and the core domains of this transactivator are necessary and sufficient to activate transcription when TBP is overexpressed .","gene":["TBP","Tat mutants"],"gene_indices_start":[20,174],"gene_indices_end":[31,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5570,"text":"Rice dwarf phytoreovirus segment S12 transcript is tricistronic in vitro .","gene":["Rice dwarf phytoreovirus segment S12 transcript"],"gene_indices_start":[0],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5571,"text":"These results indicate that both N- and C-terminal mutations are required to inhibit transrepression by FBR protein and that multiple structural mutations accompanied by posttranslational protein modification alter gene regulation by FBR protein .","gene":["FBR protein","FBR protein"],"gene_indices_start":[104,234],"gene_indices_end":[115,245],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5573,"text":"The results of this study suggest that NF-kappaB activity may be regulated by its interaction with the cell cycle regulatory protein , E2F-1 .","gene":["E2F-1","NF-kappaB"],"gene_indices_start":[39,135],"gene_indices_end":[48,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5574,"text":"In accordance with clinical improvement we found a decrease of laboratory indicators of inflammation ( C-reactive protein , alpha 2-globuline , prostaglandin E2 ) .","gene":["alpha 2-globuline","C-reactive protein"],"gene_indices_start":[103,124],"gene_indices_end":[121,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5575,"text":"Dominant negative Sos did not affect carbachol stimulation of HA-ERK2 but inhibited the stimulatory effect of EGF by 60% .","gene":["EGF","Sos","HA-ERK2"],"gene_indices_start":[18,62,110],"gene_indices_end":[21,69,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5576,"text":"The PRB-1b gene encodes for a basic-type component of the pathogenesis-related PR-1 protein family .","gene":["PR-1 protein family","PRB-1b gene"],"gene_indices_start":[4,79],"gene_indices_end":[15,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5577,"text":"Two-dimensional phosphotryptic analyses indicate that phosphorylation on Ser-12 and Ser-48 in unstimulated cells is associated with the ability of overexpressed pp60c-src to potentiate beta-adrenergic signalling .","gene":["pp60c-src"],"gene_indices_start":[161],"gene_indices_end":[170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5579,"text":"A 2 . 3-kb full-length cDNA clone of an Atlantic halibut Mx gene was isolated from a liver cDNA library .","gene":["Atlantic halibut Mx gene"],"gene_indices_start":[40],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5580,"text":"A 20-base pair oligonucleotide containing this nonamer confers up-regulation by hypoxia and inhibition by unsaturated fatty acids when placed upstream of a heterologous promoter in a lacZ reporter construct .","gene":["lacZ reporter construct"],"gene_indices_start":[183],"gene_indices_end":[206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5581,"text":"Mapping the cAMP receptor protein contact site on the alpha subunit of Escherichia coli RNA polymerase .","gene":["cAMP receptor protein contact site","Escherichia coli RNA polymerase"],"gene_indices_start":[12,71],"gene_indices_end":[46,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5582,"text":"Transforming growth factor ( TGF ) -beta1 induces extracellular matrix deposition and proliferation of mesenchymal cells .","gene":["Transforming growth factor ( TGF ) -beta1"],"gene_indices_start":[0],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5586,"text":"These data suggest that mammalian erythroid alpha-spectrin evolved by duplication and rapid divergence from an ancestral alpha-fodrin-like gene .","gene":["alpha-fodrin-like gene","alpha-spectrin"],"gene_indices_start":[44,121],"gene_indices_end":[58,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5587,"text":"Immunologically reactive insulin levels were determined in freely-moving normal rats offered three different test-meals .","gene":["insulin"],"gene_indices_start":[25],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5588,"text":"Transcriptional blockade was reversed by co-transfections of a wild-type SRF expression vector , but was not rescued by the expression of other myogenic factors , such as MyoD and Mef-2C .","gene":["Mef-2C","MyoD","wild-type SRF"],"gene_indices_start":[63,171,180],"gene_indices_end":[76,175,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5595,"text":"By negatively regulating GRK-mediated receptor phosphorylation , beta-arrestin-mediated processes such as Src recruitment and clathrin-mediated internalization , which are required for GPCR-mediated ERK activation , are inhibited , thus dampening further ERK activation .","gene":["ERK","ERK","Src"],"gene_indices_start":[106,199,255],"gene_indices_end":[109,202,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5597,"text":"The patients who presented with mucocutaneous disease also had low CD4+ T lymphocyte counts , and most of them had AIDS defining illnesses .","gene":["CD4+"],"gene_indices_start":[67],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5599,"text":"C . D2-Chr 4 congenic strains harboring DBA \/ 2 alleles associated with the Pctr1 locus contained DBA \/ 2 \"resistant\" alleles of the CDK4 \/ CDK6 inhibitors p16 and p15 .","gene":["p16","CDK4 \/ CDK6","DBA \/ 2 alleles","p15","DBA \/ 2 \"resistant\" alleles","Pctr1 locus"],"gene_indices_start":[40,76,98,133,156,164],"gene_indices_end":[55,87,125,144,159,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5601,"text":"Finally , Cas existed mainly in cytosol and membrane cytoskeleton fractions in the resting state , and remained unchanged during platelet aggregation , when FAK translocated to the cytoskeletal fraction .","gene":["Cas","FAK"],"gene_indices_start":[10,157],"gene_indices_end":[13,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5602,"text":"On the basis of serum alpha1AT quantitation , newborn infants may be separated into two groups , characterized respectively by concentrations above or below 150 mg% .","gene":["serum alpha1AT"],"gene_indices_start":[16],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5604,"text":"The present data also suggest that when compared to the systemic vascular bed , the pulmonary vascular bed is less responsive to bolus administration of ET-1 .","gene":["ET-1"],"gene_indices_start":[153],"gene_indices_end":[157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5608,"text":"Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe .","gene":["Ste4","Byr2"],"gene_indices_start":[18,51],"gene_indices_end":[22,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5609,"text":"After two successive rounds of selection by focus formation assay , a transforming ribozyme ( Rz007 ) was identified .","gene":["transforming ribozyme","Rz007"],"gene_indices_start":[70,94],"gene_indices_end":[91,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5611,"text":"This work unravels a new model for the ets-1 \/ ets-2 gene's evolution , based for the first time on both structural and functional evidences .","gene":["ets-1 \/ ets-2"],"gene_indices_start":[39],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5612,"text":"Molecular cloning and sequencing of a cDNA encoding SR beta revealed that SR beta is a transmembrane protein and , like SR alpha and SRP54 , is a member of the GTPase superfamily .","gene":["SR alpha","SR beta","GTPase superfamily","SR beta","SRP54"],"gene_indices_start":[52,74,120,133,160],"gene_indices_end":[59,81,128,138,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5615,"text":"RACK1 , a receptor for activated C kinase and a homolog of the beta subunit of G proteins , inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells .","gene":["RACK1","G proteins","src tyrosine kinases","activated C kinase"],"gene_indices_start":[0,23,79,113],"gene_indices_end":[5,41,89,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5616,"text":"The polyubiquitin gene was transcribed throughout the Volvox life cycle with peaks in the 1 . 6-kb mRNA levels during pre-cleavage , cleavage , and post-inversion .","gene":["polyubiquitin gene"],"gene_indices_start":[4],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5617,"text":"DNase I and 1 , 10-phenanthroline-copper footprinting of MURA-Mu1 TIR complexes indicate that MURA binds to a conserved approximately 32-bp region in the TIR of Mu1 .","gene":["MURA-Mu1 TIR complexes","DNase I","TIR","Mu1","MURA"],"gene_indices_start":[0,57,94,154,161],"gene_indices_end":[7,79,98,157,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5618,"text":"We and others have demonstrated that the c-cbl proto-oncogene product is one of the earliest targets of tyrosine phosphorylation upon T cell receptor stimulation .","gene":["c-cbl proto-oncogene product","T cell receptor"],"gene_indices_start":[41,134],"gene_indices_end":[69,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5621,"text":"The use of specific antibodies allowed the identification of at least RAR beta in some of the DNA-protein complexes , although the four sequences bind single RARs transfected in COS cells much less efficiently , or not at all , when compared to a canonical RAR responsive element .","gene":["RAR beta","RAR responsive element","RARs"],"gene_indices_start":[70,158,257],"gene_indices_end":[78,162,279],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5622,"text":"Although increased expression of the HMG-I \/ Y proteins is associated with cellular proliferation , neoplastic transformation , and several human cancers , the role of these proteins in the pathogenesis of malignancy remains unclear .","gene":["HMG-I \/ Y proteins"],"gene_indices_start":[37],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5624,"text":"These results demonstrate that sequences in the SH2 \/ SH3 \/ SH2 region of p120 GAP are required for full catalytic activity toward Ras .","gene":["Ras","p120 GAP","SH2 \/ SH3 \/ SH2 region"],"gene_indices_start":[48,74,131],"gene_indices_end":[70,82,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5625,"text":"We have isolated a binding partner for the Fanconi anemia group C protein ( FANCC ) by yeast two-hybrid screening .","gene":["FANCC","Fanconi anemia group C protein"],"gene_indices_start":[43,76],"gene_indices_end":[73,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5626,"text":"The effects of coenzyme Q10 ( CoQ ) and captopril on functional capacity , hemodynamics and survival were studied in 154 rats that recovered after experimental myocardial infarction .","gene":["coenzyme Q10","CoQ"],"gene_indices_start":[15,30],"gene_indices_end":[27,33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5627,"text":"Novel intronic promoter in the rat ER alpha gene responsible for the transient transcription of a variant receptor .","gene":["rat ER alpha gene"],"gene_indices_start":[31],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5628,"text":"In assays with purified enzymes , wild-type but not PTPS-S19A was a specific substrate for the cGMP-dependent protein kinase ( cGK ) type I and II .","gene":["PTPS-S19A","cGMP-dependent protein kinase ( cGK ) type I and"],"gene_indices_start":[52,95],"gene_indices_end":[61,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5630,"text":"Effects of rhG-CSF on neutrophil functions and survival in sepsis induced diabetic rats .","gene":["rhG-CSF"],"gene_indices_start":[11],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5631,"text":"Each of these genes contains a putative upstream ORF , while STA2 has two additional in-frame AUG codons 5' to the major cistron .","gene":["STA2"],"gene_indices_start":[61],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5632,"text":"BRCA1 protein contains an amino-terminal zinc finger motif and a carboxy-terminal acidic region .","gene":["BRCA1 protein"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5633,"text":"Eleven patients tested positive for the hepatitis B surface antigen ( HBsAg ) .","gene":["hepatitis B surface antigen","HBsAg"],"gene_indices_start":[40,70],"gene_indices_end":[67,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5636,"text":"Hrs has a FYVE double zinc finger domain , which specifically binds phosphatidylinositol ( 3 ) -phosphate and is conserved in several proteins involved in vesicular traffic .","gene":["Hrs","FYVE double zinc finger domain"],"gene_indices_start":[0,10],"gene_indices_end":[3,40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5639,"text":"Mutational analysis of the L1 binding site of 23S rRNA in Escherichia coli .","gene":["L1 binding site","23S rRNA in Escherichia coli"],"gene_indices_start":[27,46],"gene_indices_end":[42,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5640,"text":"We propose that the reduced responsiveness of CYP3A2 is the result of preferential binding of COUP-TF at the CYP3A2 DexRE-1 site .","gene":["CYP3A2 DexRE-1 site","COUP-TF","CYP3A2"],"gene_indices_start":[46,94,109],"gene_indices_end":[52,101,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5641,"text":"Location and orientation of an activating region in the Escherichia coli transcription factor , FNR .","gene":["FNR"],"gene_indices_start":[96],"gene_indices_end":[99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5642,"text":"( iii ) The mRNA is not efficiently polyadenylated at sequences in the 3' end of the DHFR cDNA but rather uses polyadenylation signals downstream from the DHFR cDNA .","gene":["DHFR cDNA","DHFR cDNA"],"gene_indices_start":[85,155],"gene_indices_end":[94,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5643,"text":"Northern blot analysis with one of the PARNAs revealed a highly abundant signal of approximately 2 . 0 kilobases ( kb ) present in all cell lines tested .","gene":["PARNAs"],"gene_indices_start":[39],"gene_indices_end":[45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5644,"text":"Therefore , the impaired floor plate development in oep mutants is not caused by the absence of the floor plate inducer shh .","gene":["oep mutants","floor plate inducer shh"],"gene_indices_start":[52,100],"gene_indices_end":[63,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5645,"text":"The cellular sequences 5' to the viral integration site exhibited 85 to 97% identity to several sequences belonging to the mouse L1 family of long interspersed repetitive sequences .","gene":["mouse L1 family"],"gene_indices_start":[123],"gene_indices_end":[138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5647,"text":"METHODS : IgG antibodies vs HHV-6 ( anti-HHV-6-IgG ) were determined by indirect immunofluorescence in 100 IVDA ( 29 seronegative and 71 seropositive for HIV-1 of which 45 were in stage II and 26 in IV-C1 of CDC ) as well as in 100 healthy subjects of a similar age ( control group ) .","gene":["anti-HHV-6-IgG","IgG antibodies"],"gene_indices_start":[10,36],"gene_indices_end":[24,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5648,"text":"An analysis of sequence of the mutant recN gene revealed a G : C to T : A transversion near the 3' end of the coding region .","gene":["mutant recN gene"],"gene_indices_start":[31],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5649,"text":"Overexpression of Sed5p allowed growth in the absence of Vti1p .","gene":["Vti1p","Sed5p"],"gene_indices_start":[18,57],"gene_indices_end":[23,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5652,"text":"When two-dimensional polyacrylamide gel electrophoretic patterns of [ 35S ] methionine-labeled proteins secreted from cells infected with parental and recombinant viruses were compared , a spot missing from the latter corresponded in molecular weigh and isoelectric point with that predicted from the N1L ORF .","gene":["N1L ORF"],"gene_indices_start":[301],"gene_indices_end":[308],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5653,"text":"T cells express two isoforms of S6k1 : a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation .","gene":["S6k1","70 kDa cytoplasmic kinase"],"gene_indices_start":[32,41],"gene_indices_end":[36,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5654,"text":"Western blot analysis showed a rapid corresponding increase in p21WAF1 \/ CIP1 protein , whereas protein levels of another member of the cyclin-dependent kinase inhibitor family , p27kip1 , were unchanged .","gene":["p27kip1","cyclin-dependent kinase inhibitor family","p21WAF1 \/ CIP1 protein"],"gene_indices_start":[63,136,179],"gene_indices_end":[85,176,186],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5655,"text":"C \/ EBPbeta LIP overexpressing HC11 cells did not express beta-casein mRNA ( mammary epithelial cell differentiation marker ) in response to lactogenic hormones .","gene":["beta-casein mRNA","C \/ EBPbeta LIP"],"gene_indices_start":[0,58],"gene_indices_end":[15,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5656,"text":"Effects of beta-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects .","gene":["beta-adrenergic receptor"],"gene_indices_start":[11],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5657,"text":"Co-transfection of the Sp1 expression plasmid and the -58 promoter construct into Drosophila Schneider cells revealed that Sp1 contributed to the kinase basal promoter activity by binding to the non-consensus site in the -58 region .","gene":["Sp1","kinase basal promoter","Sp1"],"gene_indices_start":[23,123,146],"gene_indices_end":[26,126,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5659,"text":"Protein sequence analysis reveals that MAN1 shares a conserved globular domain of approximately 40 amino acids , which we term the LEM module , with inner nuclear membrane proteins lamina-associated polypeptide 2 and emerin .","gene":["LEM module","MAN1","lamina-associated polypeptide 2","emerin"],"gene_indices_start":[39,131,181,217],"gene_indices_end":[43,141,212,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5660,"text":"This shows that the characteristically diffuse banding pattern of plant nuclear proteins interacting with the G-box is also observed in a binding assay using only one recombinant GBF .","gene":["recombinant GBF"],"gene_indices_start":[167],"gene_indices_end":[182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5661,"text":"Based on these results and because Cdc68 has been implicated as a regulator of chromatin structure , we postulate that polymerase alpha may interact with these proteins to gain access to its template or to origins of replication in vivo .","gene":["Cdc68","polymerase alpha"],"gene_indices_start":[35,119],"gene_indices_end":[40,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5662,"text":"Mutants lacking any tyrosine residues in the cytoplasmic domain maintain their ability to activate STAT5 and STAT1 but cannot activate STAT3 , implying that STAT5 and STAT1 activation does not require receptor tyrosine phosphorylation .","gene":["STAT1","STAT5","STAT3","STAT1","STAT5"],"gene_indices_start":[99,109,135,157,167],"gene_indices_end":[104,114,140,162,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5663,"text":"Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency .","gene":["latent membrane protein 2A","protein tyrosine kinase"],"gene_indices_start":[16,60],"gene_indices_end":[42,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5665,"text":"These results support the hypothesis that in the presence of tryptophan the ribosome translating tnaC blocks Rho's access to the boxA and rut sites , thereby preventing transcription termination .","gene":["boxA","rut sites","tnaC"],"gene_indices_start":[97,129,138],"gene_indices_end":[101,133,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5666,"text":"Recently , an alternatively spliced form of c-myb-encoded mRNA has been identified in murine cells containing either normal or rearranged c-myb genes .","gene":["c-myb-encoded mRNA","c-myb genes"],"gene_indices_start":[44,138],"gene_indices_end":[62,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5668,"text":"Endogenous RMP was immunologically detected interacting with assembled RPB5 in RNA polymerase in mammalian cells .","gene":["RNA polymerase","RMP","RPB5"],"gene_indices_start":[11,71,79],"gene_indices_end":[14,75,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5669,"text":"Transcriptional activation by thyroid hormone ( T3 ) requires interactions between the T3 receptor ( TR ) and T3 response elements ( TREs ) composed of two copies of sequences related to AGGTCA .","gene":["T3 response elements","TREs","AGGTCA","T3 receptor","TR"],"gene_indices_start":[87,101,110,133,187],"gene_indices_end":[98,103,130,137,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5671,"text":"Rhizobium meliloti large plasmid pRmeGR4b carries the nodulation competitiveness locus nfe responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots .","gene":["nfe"],"gene_indices_start":[87],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5672,"text":"Sp1 binds the CTC repeat with an affinity , KD = 0 . 37 nM , at least as high as the consensus GC box .","gene":["Sp1"],"gene_indices_start":[0],"gene_indices_end":[3],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5673,"text":"Clinical aspects of early increase in serum gamma-glutamyl transferase in cerebral infarction .","gene":["gamma-glutamyl transferase"],"gene_indices_start":[44],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5675,"text":"A cause of increase of alkaline phosphatase in children .","gene":["alkaline phosphatase"],"gene_indices_start":[23],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5676,"text":"The physical linkage of the FHR2 and the factor H genes provides additional evidence for a close relatedness of complement factor H and the factor H-related proteins .","gene":["factor H-related proteins","complement factor H","factor H genes","FHR2"],"gene_indices_start":[28,41,112,140],"gene_indices_end":[32,55,131,165],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5677,"text":"Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth : crosstalk with tyrosine kinase signaling pathway .","gene":["tyrosine kinase","Protein kinase A-Ialpha"],"gene_indices_start":[0,109],"gene_indices_end":[23,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5678,"text":"BiP670 retains basal and Ca2+ ionophore A23187-inducible activities .","gene":["BiP670"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5679,"text":"This is in contrast to PPARgamma2 , which was previously shown to be phosphorylated at a single site in a motif that is not homologous to the sites now described in PPARalpha .","gene":["PPARgamma2","PPARalpha"],"gene_indices_start":[23,165],"gene_indices_end":[33,174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5681,"text":"Also , the EWS protein stimulates transcription mediated by the COOH-terminal transactivation domain of the cofactor CREB-binding protein ( CBP ) .","gene":["EWS protein","CREB-binding protein","CBP"],"gene_indices_start":[11,117,140],"gene_indices_end":[22,137,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5682,"text":"This is the first study in which mutation screening has been performed for both the EXT1 and EXT2 genes prior to any linkage analysis .","gene":["EXT2 genes","EXT1"],"gene_indices_start":[84,93],"gene_indices_end":[88,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5683,"text":"In a stepwise logistic regression analysis of SPT and RAST data , the occurrence of serum IgE antibodies to P . orbiculare had the highest explanatory value for current eczema .","gene":["serum IgE antibodies to P . orbiculare"],"gene_indices_start":[84],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5686,"text":"To understand the function of receptor-linked tyrosine phosphatases in neural development , we sought to identify LAR isoforms preferentially expressed in the nervous system and cellular processes regulating LAR alternative splicing .","gene":["receptor-linked tyrosine phosphatases","LAR","LAR isoforms"],"gene_indices_start":[30,114,208],"gene_indices_end":[67,126,211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5689,"text":"The ATR-X syndrome results from mutations of the XH2 gene , located on the X chromosome ( Xq13 . 3 ) and coding for a transacting factor which regulates gene expression .","gene":["XH2 gene"],"gene_indices_start":[49],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5691,"text":"These data establish Smd1p as a required component of the cellular splicing apparatus and a factor in snRNA maturation and stability .","gene":["Smd1p"],"gene_indices_start":[21],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5693,"text":"Their use resulted in a sensitivity of 73% and a specificity of 74% with regard to predictability of ALT levels increasing during the trial .","gene":["ALT"],"gene_indices_start":[101],"gene_indices_end":[104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5695,"text":"This repression was mediated through binding to the E2 DNA-binding site immediately upstream of the P105 promoter TATA box and could be abrogated by preincubation of the HPV-18 P105 promoter template with the nuclear extract allowing the formation of the preinitiation complex .","gene":["E2 DNA-binding site","HPV-18 P105 promoter","P105"],"gene_indices_start":[52,100,170],"gene_indices_end":[71,104,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5697,"text":"We demonstrate here that the -DEDDDL sequence stabilizes GDP binding to Ran , and that the domain is required for high affinity interaction with a Ran-binding protein , HTF9A \/ RanBP1 .","gene":["HTF9A \/ RanBP1","-DEDDDL sequence","Ran-binding protein","Ran"],"gene_indices_start":[29,72,147,169],"gene_indices_end":[45,75,166,183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5698,"text":"We conclude that c-Abl activates c-myc transcription indirectly with no requirement for DNA binding by c-Abl .","gene":["c-myc","c-Abl","c-Abl"],"gene_indices_start":[17,33,103],"gene_indices_end":[22,38,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5699,"text":"Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily .","gene":["nuclear receptor superfamily"],"gene_indices_start":[107],"gene_indices_end":[135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5700,"text":"Despite this DNA binding activity , AP-1 reporter activity was suppressed in these cells .","gene":["AP-1 reporter"],"gene_indices_start":[36],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5701,"text":"Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation .","gene":["mitogen-activated protein kinase","cot oncoprotein","c-jun promoter"],"gene_indices_start":[9,73,96],"gene_indices_end":[41,88,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5702,"text":"Inspection of enhancer mutants suggests that trans-activation by hLEF \/ GAL4 is especially dependent on TCF-2 , a distinct T-cell-enriched protein that binds to sequences flanking the hLEF-binding site in the enhancer .","gene":["hLEF-binding site","TCF-2","hLEF \/ GAL4"],"gene_indices_start":[65,104,184],"gene_indices_end":[76,109,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5703,"text":"Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking .","gene":["HIV-1 integrase"],"gene_indices_start":[20],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5704,"text":"Surprisingly , calf thymus CstF contained an additional , novel form of the 64-kDa subunit with a molecular mass of 70 kDa .","gene":["calf thymus CstF"],"gene_indices_start":[15],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5706,"text":"In vitro DNase I footprinting showed that OxyR-C199S protected Pmom from -104 to -46 on the top strand and produced a protection pattern characteristic of reduced wild-type OxyR .","gene":["OxyR-C199S","reduced wild-type OxyR","DNase I","Pmom"],"gene_indices_start":[9,42,63,155],"gene_indices_end":[16,52,67,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5707,"text":"Growth factors induce the expression of the immediate early gene products MAP kinase phosphatase-1 ( MKP-1 ) , c-Fos and c-Jun .","gene":["immediate early gene products","c-Jun","MAP kinase phosphatase-1","MKP-1","Growth factors","c-Fos"],"gene_indices_start":[0,44,74,101,111,121],"gene_indices_end":[14,73,98,106,116,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5711,"text":"The corresponding inhibition of acid phosphatase activity in control male and female guinea pigs was 15 . 91% and 20 . 33% respectively .","gene":["acid phosphatase"],"gene_indices_start":[32],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5712,"text":"It also contains a picornaviral 3C-like protease domain and two papain-like protease domains .","gene":["papain-like protease domains","picornaviral 3C-like protease domain"],"gene_indices_start":[19,64],"gene_indices_end":[55,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5714,"text":"All other normal and transformed lymphoid and nonlymphoid cell lines and normal tissues were negative for PANG expression except for the brain , wherein unique 4 . 0- and 6 . 1-kb transcripts were detected .","gene":["PANG"],"gene_indices_start":[106],"gene_indices_end":[110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5715,"text":"A cDNA , cak1At , was isolated that suppressed the CAK mutation in budding yeast , and it also complemented a fission yeast CAK mutant . cak1At encodes a protein related to animal CAKs .","gene":["cak1At","animal CAKs","CAK mutation","cak1At","fission yeast CAK mutant"],"gene_indices_start":[9,51,110,137,173],"gene_indices_end":[15,63,134,143,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5718,"text":"The HGF-induced cell motility was mimicked by 12-0-tetradecanoyl-phorbol-13-acetate , a protein kinase C-activating phorbol ester , but not by Ca2+ ionophore .","gene":["protein kinase"],"gene_indices_start":[88],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5719,"text":"These results demonstrate that a class of proline-rich activator proteins and RNA polymerase II possess a common structural and functional component which can interact with the same target in the general transcription machinery .","gene":["RNA polymerase II"],"gene_indices_start":[78],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5721,"text":"Another mutant , T255A , lost the ability to bind E4orf6 , but unexpectedly , viral late-gene expression was not affected .","gene":["E4orf6"],"gene_indices_start":[50],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5722,"text":"In addition , they display common features that make them strikingly related to snoRNA U14 .","gene":["snoRNA U14"],"gene_indices_start":[80],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5723,"text":"The second class of cDNA hybridized to a 13 kb transcript , which was approximately twice as large as the mammalian lactase mRNA .","gene":["mammalian lactase mRNA"],"gene_indices_start":[106],"gene_indices_end":[128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5725,"text":"The corresponding differences in FVIIa and PAI-1 were not statistically significant .","gene":["FVIIa","PAI-1"],"gene_indices_start":[33,43],"gene_indices_end":[38,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5726,"text":"Deletion mapping of the human presenilin-1 ( PS1 ) promoter delineated the most active fragment from -118 to +178 in relation to the transcription start site mapped in this study , in both human neuroblastoma SK-N-SH and hepatoma HepG2 cells .","gene":["human presenilin-1","PS1"],"gene_indices_start":[24,45],"gene_indices_end":[42,48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5729,"text":"Src homology ( SH ) domain dependent protein-protein interactions are important to tyrosine kinase receptor signal transduction .","gene":["Src homology","SH","tyrosine kinase receptor"],"gene_indices_start":[0,15,83],"gene_indices_end":[12,17,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5731,"text":"To gain insight into the possible involvement of p21 in liver cell growth , the expression and regulation of the p21 gene was evaluated in rodent models of liver regeneration and specimens of human liver diseases .","gene":["p21 gene","p21"],"gene_indices_start":[49,113],"gene_indices_end":[52,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5736,"text":"Moreover , we found that cyclin E , in contrast to cyclin D1 , was required for the G1 \/ S transition even in cells lacking retinoblastoma protein function .","gene":["cyclin D1","cyclin E","retinoblastoma protein"],"gene_indices_start":[25,51,124],"gene_indices_end":[33,60,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5738,"text":"Whereas p82 expression had no effect on ERK2 activation by p126 , p70 completely abrogated this activity .","gene":["p70","p126","p82","ERK2"],"gene_indices_start":[8,40,59,66],"gene_indices_end":[11,44,63,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5740,"text":"Electrophoretic mobility shift assays and competition experiments showed that site A is recognized by an NF1 protein .","gene":["NF1 protein"],"gene_indices_start":[105],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5741,"text":"Drosophila orthodenticle ( otd ) and murine Otx genes exemplify this , both in terms of expression patterns and mutant phenotypes .","gene":["Drosophila orthodenticle","murine Otx genes","otd"],"gene_indices_start":[0,27,37],"gene_indices_end":[24,30,53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5742,"text":"The ARG SH2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10-fold less strongly than the ABL SH2 domain .","gene":["BCR","ARG","SH2 domain","ABL","SH2 domain"],"gene_indices_start":[4,8,58,126,130],"gene_indices_end":[7,18,61,129,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5746,"text":"We show that HRI and dsRNA-PK phosphorylate yeast eIF-2 alpha in vitro and in vivo and functionally substitute for GCN2 protein to stimulate GCN4 translation in yeast .","gene":["HRI","dsRNA-PK","yeast eIF-2 alpha","GCN2 protein","GCN4"],"gene_indices_start":[13,21,44,115,141],"gene_indices_end":[16,29,61,127,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5747,"text":"Two soybean cDNA clones , SPK-3 and SPK-4 , encoding putative protein kinases were isolated and characterized .","gene":["SPK-3","SPK-4","protein kinases"],"gene_indices_start":[26,36,62],"gene_indices_end":[31,41,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5749,"text":"Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK \/ ERK activations .","gene":["epidermal growth factor","MEK \/ ERK"],"gene_indices_start":[76,118],"gene_indices_end":[99,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5750,"text":"Eleven strains of Fusarium poae and F . sporotrichioides from the U . S . S . R . and 7 strains of these species and one of F . sporotrichioides var . tricinctum from U . S . A . and France have been compared as to their capacity to yield T-2 toxin .","gene":["T-2 toxin"],"gene_indices_start":[239],"gene_indices_end":[248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5752,"text":"This conclusion was confirmed by Northern blotting analysis of the 5'-flanking region of CAD gene .","gene":["CAD gene"],"gene_indices_start":[89],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5753,"text":"The ARF promoter was also found to be highly responsive to E2F1 expression , in keeping with previous results at the RNA level .","gene":["ARF promoter","E2F1"],"gene_indices_start":[4,59],"gene_indices_end":[16,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5758,"text":"Using an interspecific backcross panel , we localized both Gng3 and Gng3lg to the same locus on chromosome 19 .","gene":["Gng3lg","Gng3"],"gene_indices_start":[59,68],"gene_indices_end":[63,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5760,"text":"An ELISA procedure was developed for monitoring the specific IgE response in dogs to Dirofilaria immitis infection .","gene":["IgE"],"gene_indices_start":[61],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5762,"text":"In adherent macrophages , absence of CD45 led to the hyperphosphorylation and hyperactivation of p56 \/ 59 ( hck ) and p53 \/ 56 ( lyn ) , but not of p58 ( c-fgr ) .","gene":["p53","p56","lyn","hck","CD45","p58 ( c-fgr )"],"gene_indices_start":[37,97,108,118,129,148],"gene_indices_end":[41,100,111,121,132,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5763,"text":"Additionally , I kappa B beta , but not I kappa B alpha , also prevented the binding of Rel to the kappa B site .","gene":["kappa B site","I kappa B beta","Rel","I kappa B alpha"],"gene_indices_start":[15,40,88,99],"gene_indices_end":[29,55,91,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5764,"text":"Although Pho85 is not essential for viability , Pcl1 , 2-Pho85 kinase complexes become essential for Start in the absence of Cln1 , 2-Cdc28 kinases .","gene":["Pho85","Pcl1 , 2-Pho85 kinase complexes","Cln1 , 2-Cdc28 kinases"],"gene_indices_start":[9,48,125],"gene_indices_end":[14,79,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5771,"text":"A stable heterologous cell line containing the mouse TRH receptor was constructed by transfection of nonexcitable 293 cells , which lack L channel activity .","gene":["mouse TRH receptor"],"gene_indices_start":[47],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5772,"text":"These data suggest that the function of the DS2 may be the protection of the nuclear DNA from desiccation .","gene":["DS2"],"gene_indices_start":[44],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5773,"text":"A recently described protein , metaxin 1 , serves as a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion .","gene":["metaxin 1"],"gene_indices_start":[31],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5780,"text":"Electrophoretic mobility shift assays with each of these sequences demonstrated complexes with mobilities identical to those of the NF-kappa B site from the kappa light-chain gene .","gene":["NF-kappa B site","kappa light-chain gene"],"gene_indices_start":[132,157],"gene_indices_end":[147,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5781,"text":"Taken together , these findings show that 16K hPRL inhibits the VEGF-induced Ras activation ; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis .","gene":["16K hPRL","Ras"],"gene_indices_start":[42,77],"gene_indices_end":[50,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5782,"text":"Transfection with a CSF-1R expression plasmid permitted CSF-1-dependent activation of the signalling pathway targeting an Ets \/ AP1 ( activator protein 1 ) element in the uPA promoter that has been shown previously to be a target of oncogenic ras and protein kinase C pathways .","gene":["Ets \/ AP1","protein kinase C pathways","CSF-1R","activator protein 1","oncogenic ras","uPA promoter"],"gene_indices_start":[20,122,134,171,233,251],"gene_indices_end":[26,131,153,183,246,276],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5783,"text":"During the 1980's , quantifications of immunoserological testings , especially C reactive protein , rheumatoid factor and antistreptolysin O , progressed rapidly .","gene":["C reactive protein","rheumatoid factor","antistreptolysin O"],"gene_indices_start":[79,100,122],"gene_indices_end":[97,117,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5786,"text":"It is the human homolog of the mouse Mx protein involved in resistance to influenza virus .","gene":["mouse Mx protein"],"gene_indices_start":[31],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5791,"text":"Recently , we have reported the cloning of the germ cell-specific , nuclear orphan receptor germ cell nuclear factor ( GCNF ) \/ RTR .","gene":["nuclear orphan receptor germ cell nuclear factor ( GCNF ) \/ RTR"],"gene_indices_start":[68],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5794,"text":"Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors .","gene":["orphan nuclear receptors","breast cancer marker gene","pS2","ERR family"],"gene_indices_start":[53,57,90,104],"gene_indices_end":[56,82,100,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5796,"text":"Such an increase in the steady-state testicular TIMP-2 mRNA level apparently is not the result of an up-regulation by germ cells because germ cells cocultured with Sertoli cells failed to elicit an increase in the Sertoli cell steady-state TIMP-2 mRNA level .","gene":["testicular TIMP-2 mRNA","TIMP-2 mRNA"],"gene_indices_start":[37,240],"gene_indices_end":[59,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5797,"text":"Transgenic mice harboring the rat TnI-CAT fusion gene expressed the reporter specifically in the skeletal muscle .","gene":["rat TnI-CAT fusion gene"],"gene_indices_start":[30],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5798,"text":"Taken together , these observations indicate that the C-terminal 24 amino acids are sufficient for NodO secretion although the region adjacent to this domain appears to affect secretion efficiency .","gene":["NodO"],"gene_indices_start":[99],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5800,"text":"Substantial evidence supports a critical role for the activation of the Raf-1 \/ MEK \/ mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation .","gene":["Raf-1 \/ MEK \/ mitogen-activated protein kinase pathway"],"gene_indices_start":[72],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5804,"text":"The course of endotoxin fever remained uninfluenced by ALS .","gene":["endotoxin"],"gene_indices_start":[14],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5807,"text":"Sequencing of a 1 . 3-kilobase fragment of the 5'-flanking region of the TSG6 gene identified TATA-like and CAAT sequences near the transcription start site .","gene":["TSG6 gene"],"gene_indices_start":[73],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5808,"text":"In support of clinical antianginal studies , the vasodilator nicorandil ( NIC ) was combined with the beta-adrenergic receptor antagonists propranolol ( PRO ) and atenolol ( ATN ) and with the calcium channel blocker diltiazem ( DTZ ) to determine their cardiovascular and pharmacokinetic interactions .","gene":["beta-adrenergic receptor"],"gene_indices_start":[102],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5810,"text":"Tyrosine phosphorylated STATs dimerize and translocate into the nucleus to activate specific genes .","gene":["STATs"],"gene_indices_start":[24],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5811,"text":"The fepA-entD and fes-entF operons in the enterobactin synthesis and transport system are divergently transcribed from overlapping promoters , and both are inhibited by the Fur repressor protein under iron-replete conditions .","gene":["fes-entF operons","fepA-entD","Fur repressor protein"],"gene_indices_start":[4,18,173],"gene_indices_end":[13,34,194],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5812,"text":"Results from transient assays using these mutants showed that the DE1 received signals from phytochromes A and B , demonstrating that this element is indeed a light-responsive element .","gene":["DE1"],"gene_indices_start":[66],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5815,"text":"Refined Cox models using a CD4 count of 150 \/ microL rather than 200 \/ microL to distinguish I0 and I1 yielded a simplified model with better fit to the observed data .","gene":["CD4"],"gene_indices_start":[27],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5816,"text":"The RPO1 of LCDV shows the highest similarity to the RPO1 of IIV6 and significant lower similarity to the eukaryotic polymerases II and III as well as to the archaebacteral subunit .","gene":["eukaryotic polymerases II and III","RPO1","RPO1"],"gene_indices_start":[4,53,106],"gene_indices_end":[8,57,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5817,"text":"Other assays also distinguished the processive replication of pNeo . Myc-2 . 4 from the dispersive labeling of control plasmids .","gene":["Myc-2"],"gene_indices_start":[69],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5818,"text":"Next , to identify regions of the promoter involved , we examined a series of tenascin-C promoter constructs with 5' deletions and showed that denatured collagen-dependent promoter activity was retained by a 122-base pair element , located -43 to -165 bp upstream of the RNA start site .","gene":["collagen-dependent promoter","tenascin-C promoter constructs"],"gene_indices_start":[78,153],"gene_indices_end":[108,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5820,"text":"Because Trp53 ( the mouse homolog of human TP53 ) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents , we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53 .","gene":["Trp53","Trp53","Tk1","mouse homolog of human TP53"],"gene_indices_start":[8,20,66,253],"gene_indices_end":[13,47,69,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5821,"text":"We concluded that activation of c-fosER mediated transcriptional inhibition of p21 ( Cip1 \/ WAF1 ) through a previously uncharacterized AP-1 site , revealing an important role for c-fos in negative control of cell cycle regulatory genes .","gene":["c-fos","AP-1 site","c-fosER","p21 ( Cip1 \/ WAF1 )"],"gene_indices_start":[32,79,136,180],"gene_indices_end":[39,98,145,185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5822,"text":"On the other hand , phosphatidyl inositol 4 , 5 bisphosphate ( PIP2 ) hydrolysis requires direct phosphorylation at tyrosine residue of the PLC-gamma1 isozyme .","gene":["PLC-gamma1 isozyme"],"gene_indices_start":[140],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5823,"text":"In the IA task , post-training intraperitoneal injections of picrotoxin and bicuculline induced a dose-dependent enhancement of retention measured 24 h after the training , while retention was not affected by bicuculline methiodide ( a GABA receptor antagonist that does not readily cross the blood-brain barrier ) .","gene":["GABA receptor"],"gene_indices_start":[236],"gene_indices_end":[249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5824,"text":"The actA gene is present as a single copy in the genome of A . chrysogenum ; and its expression level , opposite to pcbC and cefEF cephalosporin biosynthetic genes , was steady during cephalosporin fermentation , showing a single 1 . 4-kb transcript .","gene":["cefEF cephalosporin biosynthetic genes","actA gene","cephalosporin","pcbC"],"gene_indices_start":[4,116,125,184],"gene_indices_end":[13,120,163,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5833,"text":"The hsp70 gene family of Neurospora crassa : cloning , sequence analysis , expression , and genetic mapping of the major stress-inducible member .","gene":["hsp70 gene family"],"gene_indices_start":[4],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5835,"text":"FK 33-824 , a methionine-enkephalin analogue , suppressed plasma ACTH to 85% of basal level , while bromocriptine ( CB-154 ) caused no significant change .","gene":["ACTH"],"gene_indices_start":[65],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5837,"text":"Previously , we showed that SNF2 , SNF5 , and SNF6 function interdependently in transcriptional activation , possibly forming a heteromeric complex .","gene":["SNF6","SNF5","SNF2"],"gene_indices_start":[28,35,46],"gene_indices_end":[32,39,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5844,"text":"The Ntl1 gene is present as a unique copy in the diploid N . plumbaginifolia species .","gene":["Ntl1 gene"],"gene_indices_start":[4],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5845,"text":"Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor , a human pituitary tumor growth-regulating factor .","gene":["PTTG","basic fibroblast growth factor"],"gene_indices_start":[18,96],"gene_indices_end":[22,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5847,"text":"After age 30 , mean hemoglobin levels for men gradually declined , while those in women rose , so that the sex difference diminished after 60 years of age .","gene":["hemoglobin"],"gene_indices_start":[20],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5848,"text":"Familial autoimmune hepatitis and C4 deficiency .","gene":["C4"],"gene_indices_start":[34],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5850,"text":"The Nur77 protein can act as a potent transcription activator and may function to regulate the expression of downstream genes in response to extracellular stimuli .","gene":["Nur77 protein"],"gene_indices_start":[4],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5851,"text":"DNase I footprinting with rat liver nuclear extracts identified 7 major protein-binding domains termed P1 through P7 in a 796 base pair DNA fragment ( base pairs -763 to +33 ) .","gene":["P1","P7","DNase I"],"gene_indices_start":[0,103,114],"gene_indices_end":[7,105,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5853,"text":"This element , termed CREsp-a ( TGACCTCA ) , differs by one nucleotide from a palindromic CRE ( CREpal , TGACGTCA ) , which is known to bind CREB as a homodimer .","gene":["CREsp-a","CREpal","CRE","TGACGTCA","CREB","TGACCTCA"],"gene_indices_start":[22,32,90,96,105,141],"gene_indices_end":[29,40,93,102,113,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5859,"text":"Autorosette-forming cells are characterized by a high activity of alkaline and acid phosphatases and low NBT-test values .","gene":["alkaline and acid phosphatases"],"gene_indices_start":[66],"gene_indices_end":[96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5863,"text":"When transiently transfected into K562 cells , this Lg genomic clone is actively transcribed , suggesting that , although it possesses the characteristics of a processed pseudogene , it is likely to correspond to the gene encoding this new ferritin subunit .","gene":["Lg","ferritin subunit"],"gene_indices_start":[52,240],"gene_indices_end":[54,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5864,"text":"The murine Htf9-a \/ RanBP1 and Htf9-c genes are divergently transcribed from a shared TATA-less promoter .","gene":["Htf9-a","RanBP1","Htf9-c genes"],"gene_indices_start":[11,20,31],"gene_indices_end":[17,26,43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5868,"text":"Amino acid sequence comparison revealed significant homology between the yeast and Escherichia coli gamma-glutamyl kinases throughout their lengths .","gene":["yeast and Escherichia coli gamma-glutamyl kinases"],"gene_indices_start":[73],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5870,"text":"Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells : evidence for two forms of the deaminase .","gene":["deaminase","double-stranded-RNA-specific adenosine deaminase"],"gene_indices_start":[45,143],"gene_indices_end":[93,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5871,"text":"The ZNF274 gene is mapped distal to marker RP S28 1 in the human chromosome 19qter region , by RH mapping .","gene":["ZNF274 gene"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5872,"text":"In ICU patients , the LIS related to the postoperative rise in IL-6 level only , even though the rise in plasma concentrations of cytokines interrelated .","gene":["IL-6"],"gene_indices_start":[63],"gene_indices_end":[67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5873,"text":"Gene constructs possessing the complete tat , rev ( tat+ rev+ ) and env genes were transiently expressed in COS-1 cells as precursor SU-TM ( gp160 ) , SU . TM ( gp120 x 41 ) , and nucleolar rev protein .","gene":["SU . TM","nucleolar rev protein","precursor SU-TM","complete tat","gp160","rev","env genes","tat+","rev+","gp120 x 41"],"gene_indices_start":[31,46,52,57,68,123,141,151,161,180],"gene_indices_end":[43,49,56,61,77,138,146,158,171,201],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5875,"text":"Disruption of ARF2 causes no detectable phenotype .","gene":["ARF2"],"gene_indices_start":[14],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5880,"text":"Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase ( endo-N ) and comparison to an endo-N homolog in bacteriophage PK1E .","gene":["bacteriophage K1F tail gene","endo-N","endo-N homolog","endo-N-acylneuraminidase"],"gene_indices_start":[36,73,100,130],"gene_indices_end":[63,97,106,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5881,"text":"In human brain , contactin was first identified by amino terminal and peptide sequencing of the lentil-lectin-binding glycoprotein Gp135 .","gene":["lentil-lectin-binding glycoprotein Gp135","contactin"],"gene_indices_start":[17,96],"gene_indices_end":[26,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5883,"text":"Based on the occurrence of several transcription signals in the Thermus pyr promoter region and strong amino acid sequence identities ( about 60% ) between Thermus PyrR and the PyrR attenuation proteins of two Bacillus sp . , we propose a regulatory mechanism involving transcriptional attenuation to control pyr gene expression in Thermus .","gene":["Thermus pyr promoter region","pyr gene","Thermus PyrR","PyrR attenuation proteins"],"gene_indices_start":[64,156,177,309],"gene_indices_end":[91,168,202,317],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5885,"text":"Detection of airborne Mycobacterium tuberculosis by air filtration and polymerase chain reaction .","gene":["polymerase"],"gene_indices_start":[71],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5887,"text":"The bHLH proteins function as potent transcriptional activators of tissue-specific genes by forming heterodimers between ubiquitous and cell-restricted family members .","gene":["bHLH proteins"],"gene_indices_start":[4],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5889,"text":"Selection was based on expression of an integrated DNA fragment containing the con-10 promoter-regulatory region followed by the initial segment of the con-10 open reading frame fused in frame with the bacterial hygromycin B phosphotransferase structural gene ( con10'-'hph ) .","gene":["con10'-'hph","con-10 promoter-regulatory region","con-10 open reading frame","bacterial hygromycin B phosphotransferase structural gene"],"gene_indices_start":[79,152,202,262],"gene_indices_end":[112,177,259,273],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5890,"text":"3 Significant reductions in lying mean arterial blood pressure were observed with daily doses of 200 mg ( - 9% ) , 400 mg ( - 10% ) and 800 mg ( - 14% ) , and were associated with significant decreases in heart rate and plasma renin activity .","gene":["plasma renin"],"gene_indices_start":[220],"gene_indices_end":[232],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5893,"text":"The data suggest that like in yeast , in plants a certain subfamily of UBC is specifically involved in the proteolytic degradation of abnormal proteins as result of stress .","gene":["UBC"],"gene_indices_start":[71],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5896,"text":"Interleukin-8 ( IL-8 ) is a potent inflammatory mediator that belongs to the family of C-X-C chemokines .","gene":["C-X-C chemokines","Interleukin-8","IL-8"],"gene_indices_start":[0,16,87],"gene_indices_end":[13,20,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5897,"text":"This motif , first described for the Drosophila homeobox activator DEAF-1 , identifies an emerging group of metazoan transcriptional modulators .","gene":["Drosophila homeobox activator DEAF-1"],"gene_indices_start":[37],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5898,"text":"Therefore , PC-PLC is a component of a signal transduction pathway leading to transcription of c-fos and junB that collaborates with c-myc and is independent of PKC-delta and Ras activation .","gene":["Ras","PKC-delta","c-myc","c-fos","PC-PLC","junB"],"gene_indices_start":[12,95,105,133,161,175],"gene_indices_end":[18,100,109,138,170,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5900,"text":"G-DNA is a four-stranded DNA structure with diverse putative biological roles .","gene":["G-DNA"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5903,"text":"Deletion of the proximal octanucleotide motif from the plasmid containing the -461 fragment of the LPL promoter , resulted in a 79 and 76% decrease in the level of expression in transfected 3T3-L1 adipocytes and HepG2 hepatocytes , respectively .","gene":["LPL promoter"],"gene_indices_start":[99],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5904,"text":"Whereas MARTA1 is clearly detectable in crude lysates , cytosolic and ribosomal salt-wash fractions , and in nuclear extracts , MARTA2 is preferentially found in the ribosomal salt-wash preparation .","gene":["MARTA1","MARTA2"],"gene_indices_start":[8,128],"gene_indices_end":[14,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5905,"text":"Blood serum erythropoietin level and basic hematological indices during the adaptation of healthy newborn infants .","gene":["Blood serum erythropoietin"],"gene_indices_start":[0],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5906,"text":"Angiotensin II induces nuclear factor ( NF ) -kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element : a stimulus-specific pathway for NF-kappaB activation .","gene":["Angiotensin II","nuclear factor ( NF ) -kappaB1 isoforms","angiotensinogen gene","NF-kappaB"],"gene_indices_start":[0,23,75,159],"gene_indices_end":[14,62,95,168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5909,"text":"Roles of the Candida albicans mitogen-activated protein kinase homolog , Cek1p , in hyphal development and systemic candidiasis .","gene":["Candida albicans mitogen-activated protein kinase homolog","Cek1p"],"gene_indices_start":[13,73],"gene_indices_end":[70,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5910,"text":"By using reporter gene constructs , it is shown that upstream sequences of the P1 promoter contain several regions that modulate the expression either positively or negatively .","gene":["P1 promoter"],"gene_indices_start":[79],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5911,"text":"RESULTS : Using information in the dbEST database of expressed sequence tags , we isolated an Arabidopsis thaliana gene ( GCR1 ) that encodes a protein with seven predicted membrane-spanning domains and other features characteristic of 7TM receptors .","gene":["7TM receptors","GCR1"],"gene_indices_start":[122,236],"gene_indices_end":[126,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5915,"text":"We speculate that the human papillomavirus late mRNAs , produced from several hundred copies of the virus genome present in infected cells , compete with the c-fos mRNAs for destabilizing cellular factors and that this may lead to elevated Fos protein levels in human papillomavirus infected cells .","gene":["Fos protein","c-fos mRNAs"],"gene_indices_start":[158,240],"gene_indices_end":[169,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5916,"text":"The deduced amino acid sequence of the gene has significant homology to the interferon regulatory factors ( IRFs ) .","gene":["IRFs","interferon regulatory factors"],"gene_indices_start":[76,108],"gene_indices_end":[105,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5919,"text":"Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila .","gene":["mitochondrial single-stranded DNA-binding protein gene"],"gene_indices_start":[14],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5920,"text":"In mitogen-stimulated splenocytes , Gfi-1 expression begins to rise at 12 h after stimulation and reaches very high levels after 50 h , suggesting that it may be functionally involved in events occurring after the interaction of IL-2 with its receptor , perhaps during the transition from the G1 to the S phase of the cell cycle .","gene":["Gfi-1","IL-2"],"gene_indices_start":[36,229],"gene_indices_end":[41,233],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5921,"text":"The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development .","gene":["Doa locus","protein kinase","LAMMER"],"gene_indices_start":[4,11,41],"gene_indices_end":[10,25,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5923,"text":"An immunoperoxidase reaction , PAP method , with the antiserum of Factor VIII as the primary antibody , was carried out in the endometrial biopsies to detect the Factor VIII activity in the endometrial endothelium before and after insertion of LNG-IUD-20 .","gene":["immunoperoxidase","Factor VIII","PAP","Factor VIII"],"gene_indices_start":[3,31,66,162],"gene_indices_end":[19,34,77,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5927,"text":"Functional analysis of DNase-I hypersensitive sites at the mouse porphobilinogen deaminase gene locus .","gene":["DNase-I","mouse porphobilinogen deaminase gene locus"],"gene_indices_start":[23,59],"gene_indices_end":[30,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5928,"text":"The synthetic DNA sequence was constructed to achieve efficient base pairing with Escherichia coli 16S ribosomal RNA , avoidance of internal secondary structure , and optimal codon usage for high-level protein expression in accord with the known preferences in E . coli .","gene":["Escherichia coli 16S ribosomal RNA"],"gene_indices_start":[82],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5929,"text":"Similarly , the sequence of the U2 RNA region shown to be involved in pre-mRNA branchpoint recognition in yeast , and exactly conserved in metazoan U2 RNAs , was totally divergent in trypanosomes .","gene":["U2 RNA region","metazoan U2 RNAs"],"gene_indices_start":[32,139],"gene_indices_end":[45,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5930,"text":"The Ras-related GTPases are small , 20- to 25-kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state .","gene":["Ras-related GTPases"],"gene_indices_start":[4],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5933,"text":"Northern and Western blot analyses demonstrated that Graf 2 is expressed in several tissues , with the highest expression in skeletal muscle .","gene":["Graf 2"],"gene_indices_start":[53],"gene_indices_end":[59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5935,"text":"Lac operators were introduced into several positions within the CAB promoter and operator-free plasmid was used as control .","gene":["CAB promoter"],"gene_indices_start":[64],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5936,"text":"c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK .","gene":["c-Fos","H-Ras-activated protein kinase","JNK","ERK"],"gene_indices_start":[0,45,90,98],"gene_indices_end":[5,75,93,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5939,"text":"The function of the C-terminal tail in telomere maintenance is not mediated through the RAP1 interacting factor RIF1 : rap1 alleles defective in both the C-terminal tail and RIF1 interaction domains have additive effects on telomere length .","gene":["RIF1","rap1 alleles","RAP1 interacting factor","RIF1 interaction domains"],"gene_indices_start":[88,112,119,174],"gene_indices_end":[111,116,131,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5940,"text":"Cloning by complementation and subsequent physical and genetic analysis revealed that it maps to RAF1 .","gene":["RAF1"],"gene_indices_start":[97],"gene_indices_end":[101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5941,"text":"An RNA-binding protein gene ( rbp1 ) from Drosophila melanogaster , encoding an RNA recognition motif and an Arg-Ser rich ( RS ) domain , has been characterized .","gene":["rbp1","RNA-binding protein gene"],"gene_indices_start":[3,30],"gene_indices_end":[27,34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5942,"text":"These single mutational defects in the eRF1-eRF3 interaction became evident when either truncated protein eRF3C or C-terminally altered eRF1 proteins were used for the authentic protein , providing further support for the presence of a C-terminal interaction .","gene":["eRF3C","eRF1","eRF1-eRF3"],"gene_indices_start":[39,106,136],"gene_indices_end":[48,111,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5944,"text":"In conclusion , marmoset monkey LHR seems to lack the sequence corresponding to exon 10 of the LHR gene in other mammalian species .","gene":["marmoset monkey LHR","LHR gene"],"gene_indices_start":[16,95],"gene_indices_end":[35,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5945,"text":"By deletion analysis of the MLS1 control region , we identified two sites , UAS1 and UAS2 , as important for efficient derepression of the gene .","gene":["MLS1","UAS1","UAS2"],"gene_indices_start":[28,76,85],"gene_indices_end":[32,80,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5946,"text":"3' RNA boundary experiments indicate that the 5' structure reduces the number of ( G \/ U ) AG repeats required for stable TRAP-trp leader RNA association .","gene":["TRAP-trp leader RNA"],"gene_indices_start":[122],"gene_indices_end":[141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5948,"text":"Overexpressing the coactivator , SRC1a or GRIP1 , further enhances ERRalpha1-induced transcriptional activity .","gene":["SRC1a","GRIP1"],"gene_indices_start":[33,42],"gene_indices_end":[38,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5951,"text":"In addition , insulin induced AP-1 DNA binding activity , this effect being totally prevented in the presence of MEK-1 inhibitor .","gene":["MEK-1","insulin","AP-1"],"gene_indices_start":[14,30,113],"gene_indices_end":[21,34,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5952,"text":"A rate-decreasing dose of physostigmine , an acetylcholinesterase inhibitor , was studied in combination with the range of atropine doses .","gene":["acetylcholinesterase"],"gene_indices_start":[45],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5954,"text":"In addition , we identified a novel type of inhibitory domain in the N-terminal 60 amino acids of IRF-1 which strongly inhibits its transcriptional activity .","gene":["IRF-1"],"gene_indices_start":[98],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5955,"text":"Similarly , expression of a transiently transfected wild-type prothymosin alpha gene as the reporter was not affected by a repertoire of myc-derived genes , including myc itself and dominant or recessive negative myc mutants .","gene":["myc-derived genes","myc mutants","myc","wild-type prothymosin alpha gene"],"gene_indices_start":[52,137,167,213],"gene_indices_end":[84,154,170,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5956,"text":"Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins .","gene":["Rb proteins","E2F3 product"],"gene_indices_start":[26,105],"gene_indices_end":[38,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5959,"text":"Processing of the NS3'-5B polyprotein was complex and occurred rapidly .","gene":["NS3'-5B polyprotein"],"gene_indices_start":[18],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5960,"text":"Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation .","gene":["HIV-1 ENV epitope","metallopeptidases","MHC class I antigen"],"gene_indices_start":[23,83,116],"gene_indices_end":[40,100,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5962,"text":"Identification of a new gene in the streptococcal plasmid pLS1 : the rnaI gene .","gene":["rnaI gene"],"gene_indices_start":[69],"gene_indices_end":[78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5964,"text":"In Experiment 1 , pups that had received an injection of the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801 ( 0 . 1 mg \/ kg , i . p . ) either 30 min before or immediately after conditioning spent less time over the conditioned odor than saline-treated controls .","gene":["N-methyl-D-aspartate receptor"],"gene_indices_start":[76],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5965,"text":"Group A was treated with three or four doses of hepatitis B immune globulin ( HBIG ) in one of three different schedules .","gene":["hepatitis B immune globulin","HBIG"],"gene_indices_start":[48,78],"gene_indices_end":[75,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5972,"text":"Immunoblotting of expressed recombinant proteins with the monoclonal 08L antibody localized the 08L epitope to the carboxyl end of the protein .","gene":["monoclonal 08L antibody","08L"],"gene_indices_start":[58,96],"gene_indices_end":[81,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5973,"text":"Consistently , activation of c-Jun N-terminal kinase downstream of Rho family GTP-binding proteins was also enhanced when Dbl was tyrosine-phosphorylated .","gene":["Rho family GTP-binding proteins","c-Jun N-terminal kinase","Dbl"],"gene_indices_start":[29,67,122],"gene_indices_end":[52,98,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5974,"text":"However , both TPN groups showed a marked increase in activities of liver lysosomal enzymes .","gene":["liver lysosomal enzymes"],"gene_indices_start":[68],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5976,"text":"Endo16 transcripts are confined to the definitive vegetal plate in blastula stage embryos ; at gastrula stage this gene is expressed throughout the archenteron , but later only in the midgut .","gene":["Endo16 transcripts"],"gene_indices_start":[0],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5977,"text":"Nuclear beta II PKC , like p34cdc2 kinase , may function to regulate nuclear lamina structural stability during cell cycle .","gene":["Nuclear beta II PKC","p34cdc2 kinase"],"gene_indices_start":[0,27],"gene_indices_end":[19,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5980,"text":"Endocrine cells were studied by means of Grimelius' silver staining and immunostaining for chromogranin , a general marker of endocrine cells .","gene":["chromogranin"],"gene_indices_start":[91],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5981,"text":"The gene encoding TRP-2 maps to mouse chromosome 14 , in the region of the coat colour mutation slaty .","gene":["coat colour mutation slaty","TRP-2"],"gene_indices_start":[18,75],"gene_indices_end":[23,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5982,"text":"Genetic and molecular data indicate that wild-type Pan and CiD compete for binding to Arm , leading to a compromised transduction of the Wg signal in heterozygous ciD \/ + animals and to a dramatic enhancement of the gain-of-function activity of CiD in homozygous mutants .","gene":["CiD","ciD \/ +","Wg","Arm","wild-type Pan","CiD"],"gene_indices_start":[41,59,86,137,163,245],"gene_indices_end":[54,62,89,139,170,248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5983,"text":"Our data therefore indicate that it is possible to engineer the HA envelope glycoprotein by fusing ligands to its amino-terminal end without affecting its fusion activity .","gene":["HA envelope glycoprotein"],"gene_indices_start":[64],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5985,"text":"The protein first identified by the monoclonal antibody Q18 is encoded by a gene located in 57A on polytene chromosomes and has been consequently named Hrb57A .","gene":["monoclonal antibody Q18","Hrb57A"],"gene_indices_start":[36,152],"gene_indices_end":[59,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5989,"text":"This R-domain may modulate the interaction with SRF , providing a mechanism that would be unique to FLI1 and EWS-FLI1 , thus implicating a novel function for these ETS transcription factors in the regulation of the Egr1 gene .","gene":["EWS-FLI1","Egr1 gene","ETS transcription factors","FLI1","SRF"],"gene_indices_start":[48,100,109,164,215],"gene_indices_end":[51,104,117,189,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5992,"text":"We have cloned and sequenced the mouse NMO1 cDNA , which encodes the NAD ( P ) H : menadione oxidoreductase [ also called NAD ( P ) H : ( quinone acceptor ) oxidoreductase ; quinone reductase ; azo dye reductase ; DT diaphorase ; EC 1 . 6 . 99 . 2 ] .","gene":["mouse NMO1 cDNA","DT diaphorase","NAD ( P ) H : ( quinone acceptor ) oxidoreductase ; quinone reductase","NAD ( P ) H : menadione oxidoreductase","azo dye reductase","EC 1 . 6 . 99 . 2 ]"],"gene_indices_start":[33,69,122,194,214,230],"gene_indices_end":[48,107,191,211,227,249],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5993,"text":"Type I cysts ( with a high K+ \/ Na+ ratio ) tend to have higher total PSA than Type II cysts .","gene":["PSA"],"gene_indices_start":[70],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5995,"text":"In summary , WT1 is enriched by oligo ( dT ) chromatography , as are U2AF65 , the U5 small nuclear RNP-associated protein p116 and hnRNP A1 .","gene":["WT1","A1","U2AF65","hnRNP","U5 small nuclear RNP-associated protein p116"],"gene_indices_start":[13,69,82,131,137],"gene_indices_end":[16,75,126,136,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5997,"text":"Electrophoretic mobility shift assays and coimmunoprecipitation studies suggest that homo- and heterodimerization occurs between cKrox family members .","gene":["cKrox family members"],"gene_indices_start":[129],"gene_indices_end":[149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":5999,"text":"This indicates that recruitment of large T antigen to the rRNA promoter by SL1 constitutes a crucial step in the activation process .","gene":["large T antigen","SL1"],"gene_indices_start":[35,75],"gene_indices_end":[50,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6001,"text":"Concomitant chronic lymphocytic leukemia , acute myeloid leukemia , and thrombosis with protein C deficiency .","gene":["protein C"],"gene_indices_start":[88],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6005,"text":"Staphylococcal enterotoxin A involvement in the illness of a 20-month-old burn patient .","gene":["Staphylococcal enterotoxin A"],"gene_indices_start":[0],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6007,"text":"Importantly , concomitant expression of constitutive activated Raf and V12N38 Ras results in almost complete loss of TTF-1 activity .","gene":["V12N38 Ras","Raf","TTF-1"],"gene_indices_start":[63,71,117],"gene_indices_end":[66,81,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6009,"text":"These studies indicate that the acidimetric test was less sensitive than the chromogenic cephalosporin substrates and that nitrocefin and S1 could be used to screen for beta-lactamase production in these tested species .","gene":["beta-lactamase"],"gene_indices_start":[169],"gene_indices_end":[183],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6011,"text":"Gel-shift assays identified two Sp1 binding sites within this element .","gene":["Sp1 binding sites"],"gene_indices_start":[32],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6012,"text":"2000 update of recommendations for the use of hematopoietic colony-stimulating factors : evidence-based , clinical practice guidelines .","gene":["hematopoietic colony-stimulating factors"],"gene_indices_start":[46],"gene_indices_end":[86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6013,"text":"The beta chain contains five potential N-linked glycosylation sites , and endoglycosidase digestion suggested that the beta chain contained multiple complex carbohydrate side chains .","gene":["endoglycosidase"],"gene_indices_start":[74],"gene_indices_end":[89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6014,"text":"Rapid detection of this mutation is achieved by restriction digestion of PCR-amplified genomic DNA ; a mismatch primer combined with the point mutation creates a Tru9I restriction site .","gene":["Tru9I restriction site"],"gene_indices_start":[162],"gene_indices_end":[184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6015,"text":"Transactivation domain is located downstream of the 128-amino-acid runt homology region , referred to as the Runt domain .","gene":["128-amino-acid runt homology region","Runt domain"],"gene_indices_start":[52,109],"gene_indices_end":[87,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6017,"text":"Mutational analysis showed that the U-box , like the RING finger in other proteins , forms the physical basis for the interaction with E2 enzymes .","gene":["E2 enzymes"],"gene_indices_start":[135],"gene_indices_end":[145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6021,"text":"A 4 . 8-kilobase BamHI-HindIII fragment encoding the entire Neurospora crassa CuZn superoxide dismutase gene ( herein designated sod-1 ) was isolated from a genomic library using two 60-base deoxyoligonucleotide probes corresponding to the published N . crassa amino acid sequence .","gene":["4 . 8-kilobase BamHI-HindIII fragment","sod-1","entire Neurospora crassa CuZn superoxide dismutase gene"],"gene_indices_start":[2,53,129],"gene_indices_end":[39,108,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6024,"text":"Thus , the B-S mutant does not mimic efficiently the chloroplastic GAPDHs , and long-range and \/ or second-layer effects , not easily predictable from visual inspection of three-dimensional structures , need to be taken into account for designing a true \"chloroplastic-like\" mutant of cytosolic GAPDH .","gene":["cytosolic GAPDH","chloroplastic GAPDHs"],"gene_indices_start":[53,285],"gene_indices_end":[73,300],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6025,"text":"It has been proposed that the parCBA operon encodes a plasmid partitioning system ( M .","gene":["parCBA operon"],"gene_indices_start":[30],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6026,"text":"The oral temperature rose and the serum creatine kinase levels fell only in those patients who were actively warmed .","gene":["serum creatine kinase"],"gene_indices_start":[34],"gene_indices_end":[55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6027,"text":"Genome plasticity in the distal tail fiber locus of the T-even bacteriophage : recombination between conserved motifs swaps adhesin specificity .","gene":["adhesin","distal tail fiber locus"],"gene_indices_start":[25,124],"gene_indices_end":[48,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6029,"text":"They were checked for anti-HCV ( anti-C100-3 ) with HCV EIA kit ( Abbott Lab . , North Chicago , IL ) .","gene":["anti-HCV","anti-C100-3"],"gene_indices_start":[22,33],"gene_indices_end":[30,44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6031,"text":"Furthermore , upstream insertion of the GSTP1 silencer element failed to inhibit activity of a heterologous promoter in MCF7 cells .","gene":["GSTP1 silencer element"],"gene_indices_start":[40],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6033,"text":"These results indicate that K-glypican is a novel GPI-anchored HSPG involved in embryonic development .","gene":["K-glypican","GPI-anchored HSPG"],"gene_indices_start":[28,50],"gene_indices_end":[38,67],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6034,"text":"Serum gastrin levels did not change in either group ; however , background serum gastrin concentrations were significantly greater for V&P patients than V&A patients throughout the study .","gene":["gastrin","gastrin"],"gene_indices_start":[6,81],"gene_indices_end":[13,88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6035,"text":"These residues , Ile244 at the extracellular end of transmembrane helix 3 , and Tyr318 at the COOH-terminal portion of extracellular loop 2 , are replaced by Leu and Ile in the PTH-1 receptor , respectively .","gene":["PTH-1 receptor"],"gene_indices_start":[177],"gene_indices_end":[191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6038,"text":"Using backcross analysis , both exons 1 and 4 mapped to a proximal region of murine Chromosome 4 indistinguishable from the vacillans gene .","gene":["vacillans gene"],"gene_indices_start":[124],"gene_indices_end":[138],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6040,"text":"Characterization of the transcription factor MTF-1 from the Japanese pufferfish ( Fugu rubripes ) reveals evolutionary conservation of heavy metal stress response .","gene":["transcription factor MTF-1"],"gene_indices_start":[24],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6041,"text":"We characterized cDNA clones specific for the extracellular matrix glycoprotein undulin .","gene":["undulin"],"gene_indices_start":[80],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6046,"text":"Results have surprisingly revealed the presence of three U14 snRNA-homologous regions positioned within introns 5 , 6 , and 8 of the mouse cognate hsc70 heat shock gene .","gene":["U14 snRNA-homologous regions","hsc70"],"gene_indices_start":[57,147],"gene_indices_end":[85,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6048,"text":"In general , the values obtained by the two methods were in agreement for each species of epidermal growth factor and followed the order : wild type greater than Glu24----Gly greater than Asp27----Gly much greater than Pro7----Thr greater than Tyr29----Gly greater than Leu47----His .","gene":["epidermal growth factor"],"gene_indices_start":[90],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6050,"text":"The mouse platelet-derived growth factor ( PDGF ) beta-receptor promoter contains a CCAAT motif , and NF-Y plays an essential role in its transcription .","gene":["NF-Y","mouse platelet-derived growth factor ( PDGF ) beta-receptor promoter"],"gene_indices_start":[4,102],"gene_indices_end":[72,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6052,"text":"The growth-promoting properties of the retroviral v-erbA oncogene , a highly mutated version of the chicken thyroid hormone receptor ( TR ) alpha , have so far exclusively been linked to dominant repression of the antimitogenic roles of TR and retinoic acid receptors .","gene":["chicken thyroid hormone receptor ( TR ) alpha","retroviral v-erbA oncogene","retinoic acid receptors","TR"],"gene_indices_start":[39,100,237,244],"gene_indices_end":[65,145,239,267],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6054,"text":"Restriction enzyme mapping and Southern analysis indicated further that the human MZF-1 gene is a single-copy gene .","gene":["human MZF-1 gene"],"gene_indices_start":[76],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6055,"text":"Anti-CRK antibodies detect a 53kDa protein in extracts of C . fasciculata in agreement with the size predicted from the nucleotide sequence of the cloned gene .","gene":["Anti-CRK antibodies"],"gene_indices_start":[0],"gene_indices_end":[19],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6056,"text":"To identify critical regions mediating growth signal transduction by hG-CSFR , deletions or site-directed amino acid substitutions were introduced into the cytoplasmic domain of hG-CSFR , and the mutant cDNAs were transfected into the murine interleukin-3 ( IL-3 ) -dependent Ba \/ F3 and FDCP cell lines .","gene":["IL-3","murine interleukin-3","hG-CSFR","hG-CSFR"],"gene_indices_start":[69,178,235,258],"gene_indices_end":[76,185,255,262],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6057,"text":"We developed a system for domain shuffling to establish the function of C1 domains from human Raf kinase and rat PKC eta in yeast .","gene":["rat PKC eta","human Raf kinase","C1 domains"],"gene_indices_start":[72,88,109],"gene_indices_end":[82,104,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6059,"text":"To isolate this gene , a P-1 artificial chromosome ( PAC ) library was screened with a full length UGT2B7 probe and a clone of approximately 100 kb in length was isolated .","gene":["full length UGT2B7"],"gene_indices_start":[87],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6063,"text":"Molecule ( s ) secreted by neuronal cultures contribute to this induction of GLT-1 , but little is known about the signaling pathways mediating this regulation .","gene":["GLT-1"],"gene_indices_start":[77],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6066,"text":"Similar to Hp140 , isolated Hp55 binds DNA with moderate strength and was a specificity for double-stranded primer-template DNA .","gene":["Hp55","Hp140"],"gene_indices_start":[11,28],"gene_indices_end":[16,32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6068,"text":"This is particularly intriguing because SKUT-1B-20 cells lack the transcription factor Pit-1 .","gene":["Pit-1"],"gene_indices_start":[87],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6069,"text":"Surprisingly , a C to G transversion at the first residue of the CAT pentanucleotide , which severely impairs the activity of both promoters , appears to increase affinity of the CAT binding protein .","gene":["CAT pentanucleotide","CAT binding protein"],"gene_indices_start":[65,179],"gene_indices_end":[84,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6070,"text":"Using a polymerase chain reaction-based approach , we cloned a 150-base pair fragment of a new sialymotif from human placenta mRNA , which was then used as a probe to clone the complete coding sequence of the corresponding gene from a cDNA library .","gene":["polymerase"],"gene_indices_start":[8],"gene_indices_end":[18],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6072,"text":"The biosynthesis and stability of the three mutant proteins were similar to those of the wild-type erbB protein , and all three retained the ability to transform chicken embryo fibroblasts .","gene":["wild-type erbB protein"],"gene_indices_start":[89],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6073,"text":"The results indicate that rep strongly enhances the function of negative regulatory elements of the LTR .","gene":["rep"],"gene_indices_start":[26],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6074,"text":"A genetic system was devised to select for pi protein mutants which discriminate between IR and DR ( York et al . , Gene ( Amst . ) 116 , 7-12 , 1992 ; York and Filutowicz , J .","gene":["pi protein mutants"],"gene_indices_start":[43],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6076,"text":"TT cells , a human MTC cell line expressing MEN 2A type RET , display transcriptionally active RelA ( p65 ) in the nucleus .","gene":["RelA","p65","MEN 2A type RET"],"gene_indices_start":[44,95,102],"gene_indices_end":[59,99,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6078,"text":"Members of SVA are also present in the complement C2 gene located about 20 kilobases upstream of RP1 in the HLA and in the cytochrome CYP1A1 gene .","gene":["RP1","SVA","complement C2 gene","HLA","cytochrome CYP1A1 gene"],"gene_indices_start":[11,39,97,108,123],"gene_indices_end":[14,57,100,111,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6079,"text":"The reduced efficiency in the glycosylase activity is also reflected in a reduced ability of S120K MutY to prevent DNA mutations in vivo .","gene":["S120K MutY","glycosylase"],"gene_indices_start":[30,93],"gene_indices_end":[41,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6082,"text":"TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae .","gene":["TOR2"],"gene_indices_start":[0],"gene_indices_end":[4],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6083,"text":"The T-cyt promoter , although of bacterial origin is active in planta and the 30 bp cyt-1 element is located within a region that is essential for T-cyt promotor activity in leaf , stem and root cells of tobacco plants .","gene":["T-cyt promotor","T-cyt promoter","30 bp cyt-1 element"],"gene_indices_start":[4,78,147],"gene_indices_end":[18,97,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6084,"text":"The weak base ketoconazole showed complete dissolution from a tablet formulation in Simulated Gastric Fluid without pepsin ( SGFsp ) within 30 minutes , 70% dissolution in 2 hours under fed state simulated upper jejunal conditions but only 6% dissolution in 2 hours under fasted state conditions .","gene":["pepsin"],"gene_indices_start":[116],"gene_indices_end":[122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6085,"text":"Phosphorylation analyses indicated that inhibition of ERK-1 \/ 2 decreased okadaic acid-elevated phosphorylation of JunD and FosB .","gene":["FosB","JunD","ERK-1 \/ 2"],"gene_indices_start":[54,115,124],"gene_indices_end":[63,119,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6086,"text":"This sequenced region of the V beta locus contains an average number of repetitive DNA elements ( 21 Alu , three L1 , three MER , and three retrovirus-related elements .","gene":["V beta locus"],"gene_indices_start":[29],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6090,"text":"This effect was not seen in conjunction with oxycodone , a morphine-like mu-receptor agonist .","gene":["morphine-like mu-receptor"],"gene_indices_start":[59],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6092,"text":"Here we demonstrate that the mechanism of activation of HIF-1alpha is a multi-step process which includes hypoxia-dependent nuclear import and activation ( derepression ) of the transactivation domain , resulting in recruitment of the CREB-binding protein ( CBP ) \/ p300 coactivator .","gene":["HIF-1alpha","CREB-binding protein","\/ p300 coactivator","CBP"],"gene_indices_start":[56,235,258,264],"gene_indices_end":[66,255,261,282],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6094,"text":"Sequence comparison of cytochromes bd and their homologs from various organisms demonstrates that the proteins can be classified into two subfamilies , a proteobacterial type including E . coli bd and a more widely distributed type including the B . stearothermophilus enzyme , suggesting that the latter type is evolutionarily older .","gene":["cytochromes bd","E . coli bd"],"gene_indices_start":[23,185],"gene_indices_end":[37,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6095,"text":"The beta subunit of the heterotrimeric G proteins that transduce signals across the plasma membrane is made up of an amino-terminal alpha-helical segment followed by seven repeating units called WD ( Trp-Asp ) repeats that occur in about 140 different proteins .","gene":["heterotrimeric G proteins"],"gene_indices_start":[24],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6102,"text":"Thus , the N-Nus complex may be affected through contacts with the CTD of the alpha subunit of RNA polymerase , as is a group of regulatory proteins that influences initiation of transcription .","gene":["RNA polymerase","N-Nus complex"],"gene_indices_start":[11,95],"gene_indices_end":[24,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6103,"text":"The highly amyloidogenic 42-residue form of Abeta ( Abeta42 ) is the first species to be deposited in both sporadic and familial AD .","gene":["Abeta42","Abeta"],"gene_indices_start":[44,52],"gene_indices_end":[49,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6104,"text":"Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha .","gene":["interferon-alpha","viral interferon regulatory factor"],"gene_indices_start":[40,129],"gene_indices_end":[74,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6105,"text":"Regulatory motifs for gene expression such as nuclear-factor-kappaB-binding-site-like sequence ( kappaB site ) and nuclear-factor-interleukin-6-binding-site-like sequence ( NF-IL-6 site ) were found in the 5'-upstream regulatory region .","gene":["nuclear-factor-interleukin-6-binding-site-like sequence","nuclear-factor-kappaB-binding-site-like sequence","NF-IL-6 site","kappaB site"],"gene_indices_start":[46,97,115,173],"gene_indices_end":[94,108,170,185],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6106,"text":"In vitro DNase I footprinting of the 200-bp proximal region of the promoter with a murine Hepa 1-6 cell nuclear extract revealed a clear footprint of a region corresponding to -80 to -28 bp of the murine fVII gene , suggesting that liver factors interact with this region of the DNA .","gene":["murine fVII gene","DNase I"],"gene_indices_start":[9,197],"gene_indices_end":[16,213],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6107,"text":"Nuclear factor III ( NFIII ) is a protein from HeLa cells that stimulates the initiation of adenovirus type 2 ( Ad2 ) DNA replication by binding to a specific nucleotide sequence in the origin , adjacent to the nuclear factor I recognition site .","gene":["Nuclear factor III","NFIII","nuclear factor I recognition site"],"gene_indices_start":[0,21,211],"gene_indices_end":[18,26,244],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6108,"text":"We have measured the kinetics of the recovery of mRNA synthesis in the inducible GAL10 and RNR3 genes after exposure of yeast cells to ultraviolet ( UV ) radiation .","gene":["GAL10","RNR3 genes"],"gene_indices_start":[81,91],"gene_indices_end":[86,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6109,"text":"These data define a conserved pathway wherein sequential histone modifications establish a \"histone code\" essential for the epigenetic inheritance of heterochromatin assembly .","gene":["histone"],"gene_indices_start":[57],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6110,"text":"UGA codon position affects the efficiency of selenocysteine incorporation into glutathione peroxidase-1 .","gene":["glutathione peroxidase-1"],"gene_indices_start":[79],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6111,"text":"Using the yeast one-hybrid screen with integrated NRE and flanking DNA as bait , the predominant clone obtained was bovine Nrl .","gene":["bovine Nrl"],"gene_indices_start":[116],"gene_indices_end":[126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6115,"text":"Furthermore , this element confers p53 induction to the otherwise nonresponsive adenovirus major late promoter .","gene":["p53"],"gene_indices_start":[35],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6118,"text":"By screening a cDNA library with a probe derived from sequences downstream of the p53p2 start site , we have cloned and characterized a cDNA that represents a mRNA that appears to have been initiated from the p53p2 promoter .","gene":["p53p2 promoter","p53p2"],"gene_indices_start":[82,209],"gene_indices_end":[87,223],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6120,"text":"Induction was reversed by coexpression of A-Fos , a dominant negative to AP-1 .","gene":["A-Fos","AP-1"],"gene_indices_start":[42,73],"gene_indices_end":[47,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6121,"text":"Plasma leptin concentrations were higher in women than men , even after the adjustment for differences in fat mass ( 28 + \/ - 3 ng \/ ml for women vs .","gene":["Plasma leptin"],"gene_indices_start":[0],"gene_indices_end":[13],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6122,"text":"Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells .","gene":["Drosophila melanogaster abl","murine v-abl proteins"],"gene_indices_start":[28,60],"gene_indices_end":[55,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6123,"text":"There are , however , several differences between the two new ars sequences .","gene":["ars sequences"],"gene_indices_start":[62],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6124,"text":"These sorting nexins also associated with the long isoform of the leptin receptor but not with the short and medium isoforms .","gene":["leptin receptor","sorting nexins"],"gene_indices_start":[6,66],"gene_indices_end":[20,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6125,"text":"Molecular cloning of the polypeptide component of the Rel-related human p75 nucleoprotein complex has revealed its identity with the 65-kDa ( p65 ) subunit of NF-kappa B .","gene":["Rel-related human p75 nucleoprotein complex","p65","NF-kappa B"],"gene_indices_start":[54,142,159],"gene_indices_end":[97,145,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6130,"text":"We describe the identification and initial characterization of neurobeachin , a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site ( K ( d ) , 10 nm ) for the type II regulatory subunit of protein kinase A ( PKA RII ) .","gene":["neurobeachin","type II regulatory subunit of protein kinase A","PKA RII"],"gene_indices_start":[63,189,238],"gene_indices_end":[75,235,245],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6133,"text":"In 3Y1 and 3Y1 v-crk-transformed fibroblasts , almost all of the total PTP1B and about 40% of total p130 ( Cas ) co-sediment with membranes composed primarily of endoplasmic reticulum .","gene":["PTP1B","p130 ( Cas )"],"gene_indices_start":[71,100],"gene_indices_end":[76,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6135,"text":"These studies have shown that the majority of tested staphylococci were resistant to penicillin G , erythromycin , and produced beta-lactamase .","gene":["beta-lactamase"],"gene_indices_start":[128],"gene_indices_end":[142],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6139,"text":"The yeast silent information regulator Sir4p anchors and partitions plasmids .","gene":["silent information regulator Sir4p"],"gene_indices_start":[10],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6142,"text":"SRY-related cDNA encoding a protein with a high-mobility-group ( HMG ) box and a leucine zipper motif , which was designated SOX-LZ , was isolated from a rainbow trout testis cDNA library .","gene":["SOX-LZ","HMG","SRY-related cDNA","high-mobility-group"],"gene_indices_start":[0,43,65,125],"gene_indices_end":[16,62,68,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6143,"text":"These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion , mediated by opiate receptors through opiate antagonism .","gene":["endogenous opioid peptides","opiate receptors"],"gene_indices_start":[49,157],"gene_indices_end":[75,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6144,"text":"In addition , a wild-type strain containing a temperature-sensitive threonyl-tRNA synthetase mutation showed increased thr operon expression at the non-permissive temperature , whereas none of the mutants showed any change .","gene":["temperature-sensitive threonyl-tRNA synthetase mutation","thr operon"],"gene_indices_start":[46,119],"gene_indices_end":[101,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6147,"text":"All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70 .","gene":["ZAP-70","SH2 domains","TAM peptides"],"gene_indices_start":[40,109,124],"gene_indices_end":[52,120,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6148,"text":"Axillary nodal status , tumour progesterone receptor status , and season of tumour detection significantly influenced survival in both older ( greater than 50 yrs ) and younger ( less than 50 yrs ) patients .","gene":["progesterone receptor"],"gene_indices_start":[31],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6149,"text":"Adjustment for age , total cholesterol , HDL cholesterol , triglycerides , current smoking , and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis .","gene":["fibrinogen"],"gene_indices_start":[156],"gene_indices_end":[166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6150,"text":"However , a cosmid clone containing the entire mouse alpha 1 ( I ) gene , including 3 . 7 kb of 5'- and 4 kb of 3'-flanking DNA , was expressed at reduced levels in fibroblasts overexpressing oncogenic ras .","gene":["mouse alpha 1 ( I ) gene","oncogenic ras"],"gene_indices_start":[47,192],"gene_indices_end":[71,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6151,"text":"It is striking that the active CHO spacer promoter violated the otherwise universal rule that metazoan RNA polymerase I promoters all have a G residue at position -16 .","gene":["metazoan RNA polymerase I promoters","CHO spacer promoter"],"gene_indices_start":[31,94],"gene_indices_end":[50,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6154,"text":"The mature AP-2 mRNA is spliced from 7 exons distributed over a region of 18 kb genomic DNA .","gene":["AP-2 mRNA"],"gene_indices_start":[11],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6156,"text":"The molecular associations dictating INCENP behavior during mitosis are currently unknown .","gene":["INCENP"],"gene_indices_start":[37],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6168,"text":"The high degree of sequence identity ( 96% ) between hydrolase B and C , particularly in the 3' untranslated region , suggests that the genes encoding these two carboxylesterases evolved by duplication and divergence of a common ancestral gene .","gene":["hydrolase B and C","carboxylesterases"],"gene_indices_start":[53,161],"gene_indices_end":[70,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6173,"text":"These sequence analyses suggest that xIRS-u is a novel member of the IRS family rather than a Xenopus homolog of an existing member .","gene":["IRS family","xIRS-u"],"gene_indices_start":[37,69],"gene_indices_end":[43,79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6174,"text":"Analysis with additional anti-peptide antibodies specific for alpha , beta , or gamma PKC indicated that all three types of PKC are expressed in JK cells ; however , JKPE cells lost a major approximately 82 kDa immunoreactive cytosolic protein detectable with anti-PKC alpha antibody .","gene":["anti-PKC alpha antibody","alpha , beta , or gamma PKC","PKC"],"gene_indices_start":[62,124,260],"gene_indices_end":[89,127,283],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6175,"text":"Reverse transcription ( RT ) -PCR products were synthesized with two degenerate primers derived from the conserved motifs of various tyrosine kinases .","gene":["tyrosine kinases"],"gene_indices_start":[133],"gene_indices_end":[149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6177,"text":"Mutations in a region located 15 to 30 bp downstream from the major transcription start site that shows good homology to a sequence in the first exon of c-fos implicated as a negative regulatory element resulted in a significant increase in basal gene expression but did not affect regulation .","gene":["c-fos"],"gene_indices_start":[153],"gene_indices_end":[158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6182,"text":"Contrary to expectations , we find a relatively high level of variation in the stripe 2 enhancer region , including point substitutions and insertion \/ deletions in binding sites , and a comparable level of variation in the other noncoding regions .","gene":["stripe 2 enhancer region"],"gene_indices_start":[79],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6185,"text":"While these findings may reflect the sensitivity of a thick myocardial wall to ischaemia during surgery , the postoperative recovery was not related to the serum CK-MB level .","gene":["serum CK-MB"],"gene_indices_start":[156],"gene_indices_end":[167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6186,"text":"Recombinant erythropoietin ( r-HuEPO ) in the treatment of anemia in multiple myeloma .","gene":["r-HuEPO","Recombinant erythropoietin"],"gene_indices_start":[0,29],"gene_indices_end":[26,36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6192,"text":"The serum levels of IgE , and asIgE and IgG-4 against 14 common food allergens were determined .","gene":["IgE","IgG-4","asIgE"],"gene_indices_start":[20,30,40],"gene_indices_end":[23,35,45],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6194,"text":"Differential expression of the \"B\" subunit of the vacuolar H ( + ) -ATPase in bovine tissues .","gene":["vacuolar H ( + ) -ATPase"],"gene_indices_start":[50],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6198,"text":"The interaction of U1-70K with the SRZ proteins is confirmed further in vitro using a blot overlay assay .","gene":["U1-70K","SRZ proteins"],"gene_indices_start":[19,35],"gene_indices_end":[25,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6199,"text":"Analysis of various deletion mutants indicates that the sequence requirements for binding by QBP in vitro are indistinguishable from those necessary for Q activity in vivo , strongly suggesting that QBP is required for the function of this TATA-independent promoter .","gene":["QBP","QBP","Q"],"gene_indices_start":[93,153,199],"gene_indices_end":[96,154,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6205,"text":"We show that cytR expression is negatively controlled by the CytR protein and positively affected by the cAMP \/ CAP complex .","gene":["cytR","CytR protein","cAMP \/ CAP complex"],"gene_indices_start":[13,61,105],"gene_indices_end":[17,73,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6207,"text":"SSG1 , a gene encoding a sporulation-specific 1 , 3-beta-glucanase in Saccharomyces cerevisiae .","gene":["sporulation-specific 1 , 3-beta-glucanase","SSG1"],"gene_indices_start":[0,25],"gene_indices_end":[4,66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6210,"text":"The regulation of PGHS-2 mRNA and protein was studied in primary cultures of bovine uterine stromal cells stimulated with phorbol 12-myristate 13-acetate ( PMA ; 100 nM ) .","gene":["PGHS-2 mRNA"],"gene_indices_start":[18],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6211,"text":"When cells were microinjected with TFOs designed to bind to a 30-bp polypurine site situated between the two TK genes , recombination was observed at frequencies in the range of 1% , 2 , 500-fold above the background .","gene":["TK genes"],"gene_indices_start":[109],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6212,"text":"Moreover , the ability to selectivity arrest elongation by polIII at defined positions within the tRNA gene transcription unit has permitted the identification of discrete functional properties of paused mammalian polIII ternary complexes .","gene":["mammalian polIII ternary complexes","polIII","tRNA gene transcription unit"],"gene_indices_start":[59,98,204],"gene_indices_end":[65,126,238],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6214,"text":"Approximately 50% of the ribosomal DNA ( rDNA ) units of Drosophila melanogaster are inactivated by two different 28 S RNA ribosomal gene insertions ( type I and type II ) .","gene":["28 S RNA ribosomal gene"],"gene_indices_start":[114],"gene_indices_end":[137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6215,"text":"Based on restriction enzyme analysis , Southern blots , polymerase chain reaction analysis and DNA sequencing , it was confirmed that the three overlapping clones isolated cover the entire cHO-1 gene , as well as approximately 10 kb of the flanking regions on both ends .","gene":["cHO-1 gene"],"gene_indices_start":[189],"gene_indices_end":[199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6220,"text":"The binding of transcription factor AP-1 and vitamin D receptor ( VDR ) to the composite AP-1 plus vitamin-D-responsive promoter region ( AP-1 + VDRE ) of the human osteocalcin gene was characterized in osteocalcin-producing ( MG-63 ) and non-producing ( U2-Os , SaOs-2 ) human osteosarcoma cell lines .","gene":["vitamin D receptor","AP-1","AP-1 + VDRE","AP-1","human osteocalcin gene","vitamin-D-responsive promoter region","VDR"],"gene_indices_start":[36,45,66,89,99,138,159],"gene_indices_end":[40,63,69,93,135,149,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6221,"text":"Ultrasound effect on the cytochrome oxidase activity .","gene":["cytochrome oxidase"],"gene_indices_start":[25],"gene_indices_end":[43],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6222,"text":"To examine the role of this CE2 element in regulating Hoxa1 expression in vivo , transgenic mice were generated which express a Hoxa1 beta-galactosidase reporter gene that contains a mutation in the CE2 element .","gene":["CE2 element","beta-galactosidase","Hoxa1","CE2 element","Hoxa1"],"gene_indices_start":[28,54,128,134,199],"gene_indices_end":[39,59,133,152,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6223,"text":"We produced transgenic plants expressing the antisense Arabidopsis HD ( AtHD1 ) gene .","gene":["AtHD1","antisense Arabidopsis HD"],"gene_indices_start":[45,72],"gene_indices_end":[69,77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6225,"text":"We have investigated the role of cellular p21ras protein in insulin and insulin-like growth factor-I ( IGF-I ) signaling pathways .","gene":["insulin-like growth factor-I","IGF-I","insulin","cellular p21ras protein"],"gene_indices_start":[33,60,72,103],"gene_indices_end":[56,67,100,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6226,"text":"This effect was abolished once the EM motif in the promoter-reporter construct was mutated , thus suggesting that the synergistic transactivation function of the TEF-1-Max heterotypic complex is mediated through binding of the complex to the EM motif .","gene":["TEF-1-Max heterotypic complex","EM motif","EM motif"],"gene_indices_start":[35,162,242],"gene_indices_end":[43,191,250],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6231,"text":"B cell antigen receptor ( BCR ) -induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40 .","gene":["B cell antigen receptor","BCR","CD40"],"gene_indices_start":[0,26,117],"gene_indices_end":[23,29,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6232,"text":"Gel retardation assays detected ZiaR-dependent complexes forming with the zia operator-promoter and ZiaR-DNA binding was enhanced by treatment with a metal-chelator in vitro .","gene":["zia operator-promoter"],"gene_indices_start":[74],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6233,"text":"Similarly , co-expression of a dominant-negative mutant of p38alpha , but not of ERK1 , ERK2 , JNK1 , or JNK2 , reduces basal and cadmium-induced pE1-luc activity .","gene":["ERK2","p38alpha","ERK1","pE1-luc","JNK2","JNK1"],"gene_indices_start":[59,81,88,95,105,146],"gene_indices_end":[67,85,92,99,109,153],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6234,"text":"A contiguous and sequentially occupied secondary Fur-binding site in entC was protected at higher Fur concentrations , extending the protected region to +49 , and sequestering the putative Shine-Dalgarno sequence .","gene":["entC","Fur","Fur-binding site"],"gene_indices_start":[49,69,98],"gene_indices_end":[65,73,101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6236,"text":"Northern analysis of the 3 . 1-kb PWP2H cDNA revealed that a 3 . 3-kb major transcript is ubiquitously expressed in human adult tissues .","gene":["3 . 1-kb PWP2H cDNA"],"gene_indices_start":[25],"gene_indices_end":[44],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6239,"text":"One linker-peptide insertion in the RsaA C terminus ( amino acid 784 ) had no effect on S-layer biogenesis , while another ( amino acid 907 ) disrupted secretion of the protein , suggesting that RsaA possesses a secretion signal lying C terminal to amino acid 784 , near or including amino acid 907 .","gene":["RsaA C terminus ( amino acid 784 )","RsaA"],"gene_indices_start":[36,195],"gene_indices_end":[70,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6248,"text":"E1 , a DNA helicase , collaborates with the HPV E2 protein in ori-dependent replication .","gene":["DNA helicase","HPV E2 protein","E1"],"gene_indices_start":[0,7,44],"gene_indices_end":[2,19,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6249,"text":"Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain .","gene":["phosphatidylinositol 3-kinase","Tec","pleckstrin homology domain","Tec kinase"],"gene_indices_start":[0,48,86,90],"gene_indices_end":[10,77,89,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6250,"text":"Together , our results show that tinman is controlled by an array of discrete enhancer elements that are activated successively by differential genetic inputs , as well as by closely linked activator and repressor binding sites within an early-acting enhancer , which restrict twist activity to specific areas within the twist expression domain .","gene":["twist expression domain","tinman","twist"],"gene_indices_start":[33,277,321],"gene_indices_end":[39,282,344],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6253,"text":"The scr regulon of pUR400 and the chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026 are both negatively controlled by a specific repressor ( ScrR ) .","gene":["chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026","scr regulon","ScrR"],"gene_indices_start":[4,34,158],"gene_indices_end":[15,100,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6254,"text":"A 215-base-pair ( bp ) region of the mouse MOPC 41 kappa light-chain immunoglobulin gene enhancer has been analyzed for specific binding of lymphoid and nonlymphoid nuclear factors .","gene":["mouse MOPC 41 kappa light-chain immunoglobulin gene enhancer"],"gene_indices_start":[37],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6256,"text":"This transition is regulated positively by G1-specific cyclin-dependent kinases ( cdks ) and negatively by the product of the retinoblastoma tumour suppressor gene , pRb .","gene":["retinoblastoma tumour suppressor gene","cdks","G1-specific cyclin-dependent kinases","pRb"],"gene_indices_start":[43,82,126,166],"gene_indices_end":[79,86,163,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6258,"text":"These RZR subtypes represent members of a new family of orphan nuclear receptors that most likely regulate specific gene expression .","gene":["orphan nuclear receptors","RZR"],"gene_indices_start":[6,56],"gene_indices_end":[9,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6259,"text":"To study the in vivo role of p16 . 7 , a phi29 mutant containing a suppressible mutation in gene 16 . 7 was constructed .","gene":["gene 16 . 7","p16 . 7"],"gene_indices_start":[29,92],"gene_indices_end":[36,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6261,"text":"In order to screen for such cofactors , we have used a transcriptionally inactive mutant of Xenopus MEF2D in a yeast two-hybrid screen .","gene":["Xenopus MEF2D"],"gene_indices_start":[92],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6262,"text":"A decamer sequence , 5'-CGA-CCCCUCC-3' , complementary to a conserved sequence adjacent to the enzymatic cleavage site on the mitochondrial RNA substrate , is present in the RNAase MRP RNA .","gene":["RNAase MRP RNA","5'-CGA-CCCCUCC-3'"],"gene_indices_start":[21,174],"gene_indices_end":[38,188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6263,"text":"In vitro translation of RNA synthesized from the cloned cDNAs predicts that P0 transcripts are translated into a novel 12 . 5-kilodalton protein corresponding to the first open reading frame .","gene":["P0 transcripts"],"gene_indices_start":[76],"gene_indices_end":[90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6267,"text":"We further found that KmMig1p is fully functional when expressed in S . cerevisiae .","gene":["KmMig1p"],"gene_indices_start":[22],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6268,"text":"It has repeatedly been shown that HCMV IE1 \/ IE2 can independently transactivate HIV-1 LTR .","gene":["IE1","IE2","HIV-1 LTR"],"gene_indices_start":[39,45,81],"gene_indices_end":[42,48,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6269,"text":"Terbutaline ; a beta2-adrenergic agonist , and aminophyllin , a phosphodiesterase inhibitor , were given separately , or in combination , to rabbit fetuses on the 28th day of gestation .","gene":["phosphodiesterase"],"gene_indices_start":[64],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6270,"text":"Comparison to other coxI genes revealed a 966-bp group I intron , which , based on homology with the related yeast coxI intron aI4 , potentially encodes a 279-amino-acid site-specific DNA endonuclease .","gene":["279-amino-acid site-specific DNA endonuclease","966-bp group I intron","coxI genes","yeast coxI intron aI4"],"gene_indices_start":[20,42,109,155],"gene_indices_end":[30,63,130,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6273,"text":"Upon analysis of the tissue distribution of AAMP , it was found to be expressed strongly in endothelial cells , cytotrophoblasts , and poorly differentiated colon adenocarcinoma cells found in lymphatics .","gene":["AAMP"],"gene_indices_start":[44],"gene_indices_end":[48],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6274,"text":"We propose that noi \/ pax2 . 1 participates in sequential signaling processes as a key integrator of midbrain-hindbrain boundary development .","gene":["noi \/ pax2 . 1"],"gene_indices_start":[16],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6278,"text":"The HMG CoA reductase inhibitors are the most effective cholesterol-lowering agents currently available .","gene":["HMG CoA reductase"],"gene_indices_start":[4],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6279,"text":"The activity of the EGF receptor promoter can be modulated by E1A protein and receptor RNA levels increased by stimulation with phorbol ester or fetal calf serum .","gene":["EGF receptor promoter","E1A protein"],"gene_indices_start":[20,62],"gene_indices_end":[41,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6280,"text":"Moreover , the observation of enhanced luteal HSP-27 phosphorylation in vivo , in late pregnancy , when PKC-delta is abundant and active , suggests that select PKC family members contribute to sHSP phosphorylation events in vivo .","gene":["luteal HSP-27","sHSP","PKC-delta","PKC family members"],"gene_indices_start":[39,104,160,193],"gene_indices_end":[52,113,178,197],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6288,"text":"These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene ( HEM15 ) had been deleted , and the phenotypes of the transformants were characterized .","gene":["HEM15","endogenous ferrochelatase gene"],"gene_indices_start":[77,110],"gene_indices_end":[107,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6289,"text":"Lyn kinase immunoprecipitated from lysates of irradiated BCP as well as a full-length glutathione S-transferase ( GST ) -Lyn fusion protein-phosphorylated recombinant human p34cdc2 on tyrosine 15 .","gene":["full-length glutathione S-transferase","recombinant human p34cdc2","Lyn kinase","GST"],"gene_indices_start":[0,74,114,155],"gene_indices_end":[10,111,117,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6291,"text":"Our observations suggest that members of the HMG-I family play an important role in SRF-dependent transcription and that their effect is mediated primarily by a protein-protein interaction .","gene":["HMG-I family"],"gene_indices_start":[45],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6298,"text":"Synergistic transactivation of the BMRF1 promoter by the Z \/ c-myb combination appears to involve direct binding by the Z protein but not the c-myb protein .","gene":["BMRF1 promoter","Z protein","c-myb protein","Z \/ c-myb"],"gene_indices_start":[35,57,120,142],"gene_indices_end":[49,66,129,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6299,"text":"Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein .","gene":["cAMP-response element-binding protein","bcl-2 promoter","Insulin-like growth factor-I"],"gene_indices_start":[0,37,85],"gene_indices_end":[28,51,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6300,"text":"METHODS : We determined an odds ratio ( OR ) , as a measure of the relative risk of being exposed to a potential interaction , comparing the use of the H2-receptor antagonist , cimetidine , with that of the noninteracting agents ranitidine , famotidine and nizatidine in users and nonusers of warfarin , phenytoin and theophylline .","gene":["H2-receptor antagonist"],"gene_indices_start":[152],"gene_indices_end":[174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6301,"text":"Long-range comparison of human and mouse SCL loci : localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences .","gene":["human and mouse SCL loci","restriction endonucleases"],"gene_indices_start":[25,88],"gene_indices_end":[49,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6302,"text":"In TNF-resistant T24 bladder carcinoma cells , TNF failed to alter EGF-R tyrosine protein kinase activity although both EGF and phorbol ester were shown to modulate the enzymatic activity of the receptor in these cells .","gene":["tyrosine protein kinase","TNF","EGF-R","EGF"],"gene_indices_start":[47,67,73,120],"gene_indices_end":[50,72,96,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6303,"text":"We isolated a ribosomal protein L18 by interaction with PKR .","gene":["PKR","ribosomal protein L18"],"gene_indices_start":[14,56],"gene_indices_end":[35,59],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6306,"text":"Insertional inactivation of sms led to increased sensitivity to the alkylating agent methylmethane sulfonate , but not to a requirement for serine or other metabolites .","gene":["sms"],"gene_indices_start":[28],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6307,"text":"Since the 5'-flanking region of this gene is likely involved in hormonal regulation of its expression , we have isolated and partially characterized an avian fatty acid synthase gene .","gene":["fatty acid synthase"],"gene_indices_start":[158],"gene_indices_end":[177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6312,"text":"A p21 peptide spanning amino acids 139-164 was found to bind PCNA in a filter binding assay and this peptide suppressed recombinant p21-PCNA interaction .","gene":["recombinant p21-PCNA","PCNA","p21 peptide"],"gene_indices_start":[2,61,120],"gene_indices_end":[13,65,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6313,"text":"Molecular characterization of malignant melanoma of soft parts or soft tissue clear cell sarcoma which shares t ( 12 ; 22 ) chromosome translocation revealed fusion of EWS with a transcriptional factor gene ATF-1 .","gene":["EWS","gene ATF-1"],"gene_indices_start":[168,202],"gene_indices_end":[171,212],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6315,"text":"The R . meliloti nifH promoter but not the K . pneumoniae nifH promoter showed sigma 54-dependent methylation protection of guanine residues at -14 , -25 and -26 , the most conserved nucleotides characteristic of sigma 54-dependent promoters .","gene":["R . meliloti nifH promoter","sigma 54-dependent promoters","K . pneumoniae nifH promoter"],"gene_indices_start":[4,43,213],"gene_indices_end":[30,71,241],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6316,"text":"Competition EMSA established that constitutively expressed nuclear proteins bound the KCS element selectively ; KCS protein binding activity correlated with promoter activity in the transient transfection reporter assay .","gene":["KCS element","KCS protein"],"gene_indices_start":[86,112],"gene_indices_end":[97,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6317,"text":"CONCLUSION : In Cdks functioning throughout the cell cycle , tyrosine phosphorylation is inhibitory to the activation of kinase , whereas the phosphorylation of threonine in the T-loop is essential for activation .","gene":["Cdks"],"gene_indices_start":[16],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6318,"text":"For the first time we describe deletion and point mutations within the plasma membrane family of guanylyl cyclase receptors that result in the formation of effective dominant negative proteins .","gene":["plasma membrane family of guanylyl cyclase receptors"],"gene_indices_start":[71],"gene_indices_end":[123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6320,"text":"MSSPs are believed to regulate DNA replication , transcription , apopotosis and cell cycle progression by interacting with the C-MYC protein .","gene":["C-MYC protein","MSSPs"],"gene_indices_start":[0,127],"gene_indices_end":[5,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6322,"text":"The human 2' , 5'-oligoadenylate ( 2-5A ) synthetases are members of a family interferon ( IFN ) -inducible anti-viral proteins .","gene":["human 2' , 5'-oligoadenylate ( 2-5A ) synthetases","IFN","interferon","anti-viral proteins"],"gene_indices_start":[4,78,91,108],"gene_indices_end":[53,88,94,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6323,"text":"Taken together , we provide evidence for the existence of an activator , NFE , which in combination with the p50 and c-Rel proteins , are part of the transcription factor machinery that regulates 3' enhancer activity , and thus the control of the IgH locus in late B lymphocyte development .","gene":["NFE","c-Rel proteins","IgH locus","p50"],"gene_indices_start":[73,109,117,247],"gene_indices_end":[76,112,131,256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6324,"text":"We show that the mouse genome contains four copies of the ubc-9 gene .","gene":["ubc-9 gene"],"gene_indices_start":[58],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6325,"text":"The AtERF genes were differentially regulated by ethylene and by abiotic stress conditions , such as wounding , cold , high salinity , or drought , via ETHYLENE-INSENSITIVE2 ( EIN2 ) -dependent or -independent pathways .","gene":["ETHYLENE-INSENSITIVE2","EIN2","AtERF genes"],"gene_indices_start":[4,152,176],"gene_indices_end":[15,173,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6326,"text":"In resting 3T3 cells , jun-D is expressed at a higher level compared to c-jun and jun-B , and its transcription is stimulated only slightly by serum growth factors .","gene":["jun-D","jun-B","growth factors","c-jun"],"gene_indices_start":[23,72,82,149],"gene_indices_end":[28,77,87,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6328,"text":"The goal of this study was to identify neuronal cell cultures that express RC3 \/ neurogranin , to check whether they are sensitive to T3 , and to examine the mechanism of regulation .","gene":["RC3 \/ neurogranin"],"gene_indices_start":[75],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6330,"text":"Here , it is shown that TAFII250 , the largest subunit of TFIID , contains two tandem bromodomain modules that bind selectively to multiply acetylated histone H4 peptides .","gene":["TFIID","histone H4 peptides","TAFII250"],"gene_indices_start":[24,58,151],"gene_indices_end":[32,63,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6334,"text":"A vector containing a transcriptionally inactive neomycin phosphotransferase II gene was used to select promoter sequences from a pool of random genomic DNA fragments .","gene":["neomycin phosphotransferase II gene"],"gene_indices_start":[49],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6336,"text":"In co-transfection studies , the expression of c-Jun plus c-Fos enhanced the transactivation of oIFNtau-CAT but the expression of GATA-1 , GATA-2 or GATA-3 did not .","gene":["c-Fos","GATA-1","GATA-2","GATA-3","c-Jun","oIFNtau-CAT"],"gene_indices_start":[47,58,96,130,139,149],"gene_indices_end":[52,63,107,136,145,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6339,"text":"Domain II is highly homologous to the LDL receptor and contains four repeats with perfect conservation of all 6 consecutive cysteines .","gene":["LDL receptor"],"gene_indices_start":[38],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6340,"text":"In light of the importance of GnRHR , the molecular mechanisms underlying the transcriptional regulation of the human GnRHR ( hGnRHR ) gene become a key issue in understanding human reproduction .","gene":["human GnRHR","hGnRHR","GnRHR"],"gene_indices_start":[30,112,126],"gene_indices_end":[35,123,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6341,"text":"Sequencing of a 40-kb DNA segment of the FK506 gene cluster from Streptomyces sp .","gene":["FK506 gene"],"gene_indices_start":[41],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6342,"text":"Thus , replication fork movement near HML pauses at a silent origin which is competent for replication initiation but kept silent through Orc2p , a component of the replication initiator .","gene":["Orc2p","HML"],"gene_indices_start":[38,138],"gene_indices_end":[41,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6345,"text":"The cglIM gene is organized in an unusual operon which contains , in addition , two genes encoding stress-sensitive restriction enzymes .","gene":["cglIM gene","restriction enzymes"],"gene_indices_start":[4,116],"gene_indices_end":[14,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6346,"text":"The Gap69C is a single-copy gene producing a major 2 . 1-kb mRNA throughout development , but its amount is decreased in larvae .","gene":["Gap69C"],"gene_indices_start":[4],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6347,"text":"The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty .","gene":["angiotensin converting enzyme","factor V Leiden mutation"],"gene_indices_start":[24,94],"gene_indices_end":[48,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6351,"text":"Diagnosis of prostatic carcinoma : the yield of serum prostate specific antigen , digital rectal examination and transrectal ultrasonography .","gene":["serum prostate specific antigen"],"gene_indices_start":[48],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6352,"text":"The deduced amino acid sequence of LvUSF2 is nearly identical to LvUSF1 except at the amino end , where they are sharply divergent .","gene":["LvUSF2","LvUSF1"],"gene_indices_start":[35,65],"gene_indices_end":[41,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6354,"text":"A consensus sequence indicates a highly conserved lysine residue , K120 of endonuclease III or K241 of Ogg1 , respectively .","gene":["endonuclease III","Ogg1"],"gene_indices_start":[75,103],"gene_indices_end":[91,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6355,"text":"Examination of various promoter deletion mutants indicated that SF-1 acts through the proximal promoter region and upstream promoter sequences .","gene":["SF-1"],"gene_indices_start":[64],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6356,"text":"The data show conclusively that phosphorylation of His-304 is not essential for any of the known functions of A . vinelandii NifL .","gene":["A . vinelandii NifL"],"gene_indices_start":[110],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6357,"text":"The maximal effect was seen at 100 ng \/ ml EGF , with a time lag of about 5 h .","gene":["EGF"],"gene_indices_start":[43],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6359,"text":"The Saccharomyces cerevisiae GAL1 and GAL10 genes are controlled in response to the availability of galactose and glucose by multiple activating and repressing proteins bound at adjacent or overlapping sites in UASG .","gene":["Saccharomyces cerevisiae GAL1","UASG","GAL10 genes"],"gene_indices_start":[4,38,211],"gene_indices_end":[33,49,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6360,"text":"These activities are all required for stimulation of cell growth by middle-T and activate members of the MAP kinase family .","gene":["MAP kinase family","middle-T"],"gene_indices_start":[68,105],"gene_indices_end":[76,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6361,"text":"When differentiated G0-arrested leaf cells were induced to resume cell division by treatment with plant hormones , cycMs4 transcription was induced before the onset of DNA synthesis .","gene":["cycMs4"],"gene_indices_start":[115],"gene_indices_end":[121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6362,"text":"Also , component I significantly correlated with fasting insulin and VO2 max for both sexes and with basal metabolism and HDL-cholesterol for females and males , respectively .","gene":["insulin","HDL-cholesterol"],"gene_indices_start":[57,122],"gene_indices_end":[64,137],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6364,"text":"The antibodies inhibited specifically the transcription of DNA polymerase alpha promoter in vitro .","gene":["DNA polymerase alpha"],"gene_indices_start":[59],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6365,"text":"Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1 \/ AML1 .","gene":["RUNX1","AML1"],"gene_indices_start":[106,114],"gene_indices_end":[111,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6366,"text":"RNase protection experiments confirmed the presence of the GHR1-279 variant in IM-9 cells and human liver .","gene":["GHR1-279 variant","RNase"],"gene_indices_start":[0,59],"gene_indices_end":[5,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6367,"text":"The open reading frames of rbsD , rbsA , and rbsC encode proteins of 139 , 501 , and 321 amino acid residues , respectively .","gene":["rbsA","rbsC","rbsD"],"gene_indices_start":[27,34,45],"gene_indices_end":[31,38,49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6368,"text":"Sucrose-specific regulation of scrB was also lost upon deletion of 4 bp of a palindromic sequence ( OB ) covering positions +6 to +21 downstream of the scrB transcriptional start site .","gene":["scrB","scrB"],"gene_indices_start":[31,152],"gene_indices_end":[35,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6369,"text":"High concentrations of tumor-associated trypsin inhibitor in hemodialyzed patients .","gene":["trypsin"],"gene_indices_start":[40],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6370,"text":"A mutation which abrogates the binding of these factors reduces Wp reporter activity specifically in B cell lines , whereas a mutation which converts the site to a consensus CREB-binding sequence maintains wild-type promoter function .","gene":["CREB-binding sequence","Wp reporter"],"gene_indices_start":[64,174],"gene_indices_end":[75,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6372,"text":"Mutation of the Sp1 element , which abolishes Sp1 binding , results in a 6-10-fold reduction in reporter activity .","gene":["Sp1 element","Sp1"],"gene_indices_start":[16,46],"gene_indices_end":[27,49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6374,"text":"Because of the potential implications of these findings in human physiology , we cloned the hPACAP-R gene .","gene":["hPACAP-R gene"],"gene_indices_start":[92],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6375,"text":"The Tax \/ IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits , IKKalpha and IKKbeta , and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK .","gene":["Tax","IKKbeta","Tax \/ IKKgamma","Tax","IKKalpha","IKK","IKK catalytic subunits"],"gene_indices_start":[4,49,60,85,98,175,206],"gene_indices_end":[18,52,82,93,105,178,209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6379,"text":"The sequence upstream of the rhlA promoter contains two inverted repeats which define putative binding sites for the RhlR regulator .","gene":["rhlA promoter","RhlR regulator"],"gene_indices_start":[29,117],"gene_indices_end":[42,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6383,"text":"Intravenous administration ( 25 mg \/ kg ) of carbonic anhydrase inhibitors ( acetazolamide , methazolamide , dichlorphenamide , sulthiame ) induced an early important rise of cortical p O2 , which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood .","gene":["carbonic anhydrase"],"gene_indices_start":[45],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6384,"text":"Cholinesterase .","gene":["Cholinesterase"],"gene_indices_start":[0],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6385,"text":"RESULTS : Surprisingly , PAF blockade increased mortality after trauma ( 5 of 11 WEB-2086 animals versus 1 of 9 vehicle animals ; p = 0 . 15 ) and depressed cardiac index and O2 delivery at 72 hours ( p < 0 . 05 ) .","gene":["PAF"],"gene_indices_start":[25],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6387,"text":"Single amino acid substitutions at the acyl-CoA-binding domain interrupt 14 [ C ] palmitoyl-CoA binding of ACBP2 , an Arabidopsis acyl-CoA-binding protein with ankyrin repeats .","gene":["ACBP2","ankyrin","acyl-CoA-binding protein"],"gene_indices_start":[107,130,160],"gene_indices_end":[112,154,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6388,"text":"Expression of GlcNAc-TI mRNA in tobacco leaves was detected using RT-PCR .","gene":["GlcNAc-TI mRNA"],"gene_indices_start":[14],"gene_indices_end":[28],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6393,"text":"Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b .","gene":["ubiquitin-homologous proteins","SUMO-1","hSMT3b","transactivator protein IE2-p86"],"gene_indices_start":[29,107,137,148],"gene_indices_end":[59,136,143,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6395,"text":"Forskolin significantly enhanced heregulin-stimulated expression of cyclin D and phosphorylation of the retinoblastoma gene product .","gene":["cyclin D","retinoblastoma gene product"],"gene_indices_start":[68,104],"gene_indices_end":[76,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6396,"text":"TaqMan analysis of gene expression following chronic FA treatment showed neither a decrease in the amount of leptin receptor ( Ob-R ) mRNA , nor an increase in the negative regulators of STAT signalling , SOCS3 ( suppressors of cytokine signalling ) or cytokine inducible sequence ( CIS ) .","gene":["suppressors of cytokine signalling","cytokine inducible sequence","STAT","Ob-R","leptin receptor","SOCS3","CIS"],"gene_indices_start":[109,127,187,205,213,253,283],"gene_indices_end":[124,131,191,210,247,280,286],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6397,"text":"It was shown by transient expression assay that HS-40 behaved as an authentic enhancer for high-level zeta 2 globin promoter activity in K562 cells , an erythroid cell line of embryonic and \/ or fetal origin .","gene":["zeta 2 globin promoter","HS-40"],"gene_indices_start":[48,102],"gene_indices_end":[53,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6398,"text":"Despite the presence of one additional ribonucleotide reductase , the nrdAB-encoded enzyme is essential to the aerobic growth of the cell because nrdAB-defective mutants of both species are not viable in the presence of oxygen .","gene":["ribonucleotide reductase","nrdAB-encoded enzyme","nrdAB-defective mutants"],"gene_indices_start":[39,70,146],"gene_indices_end":[63,90,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6400,"text":"A suspected hypothalamic dysfunction and a slightly impaired pituitary function manifested as GH deficiency were their common endocrinological features .","gene":["GH"],"gene_indices_start":[94],"gene_indices_end":[96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6401,"text":"CXCR4 is a chemokine receptor and a coreceptor for T-cell-line-tropic ( X4 ) and dual-tropic ( R5X4 ) human immunodeficiency virus type 1 ( HIV-1 ) isolates .","gene":["CXCR4","chemokine receptor"],"gene_indices_start":[0,11],"gene_indices_end":[5,29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6402,"text":"Implication of PAF and acetylhydrolase ( PAF-AH ) activity in periodontal disease .","gene":["acetylhydrolase","PAF-AH","PAF"],"gene_indices_start":[15,23,41],"gene_indices_end":[18,38,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6403,"text":"Coactivation of endogenous or exogenous G ( q ) -coupled receptors with the delta-opioid receptor produced strong stimulations of PLCbeta and such responses could be partially blocked by pertussis toxin .","gene":["pertussis toxin","PLCbeta","G ( q ) -coupled receptors","delta-opioid receptor"],"gene_indices_start":[40,76,130,187],"gene_indices_end":[66,97,137,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6404,"text":"CONCLUSION : The results demonstrate that at the site of lumbar disc herniation , inflammatory cytokines such as interleukin-1 alpha are produced , which increases prostaglandin E2 production .","gene":["interleukin-1 alpha"],"gene_indices_start":[113],"gene_indices_end":[132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6405,"text":"Currents aspects of H2 receptor antagonists in the treatment of ulcers .","gene":["H2 receptor"],"gene_indices_start":[20],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6406,"text":"Here , we report the complete structure of the human topoisomerase IIalpha gene , which consists of 35 exons spanning 27 . 5 kb .","gene":["human topoisomerase IIalpha gene"],"gene_indices_start":[47],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6408,"text":"Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse ( twy \/ twy ) in vivo .","gene":["twy \/ twy","Calcitonin"],"gene_indices_start":[0,126],"gene_indices_end":[10,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6409,"text":"SCA was resistant to inhibitors of serine , aspartyl , and metalloproteases , but it was sensitive to N-ethylmaleimide .","gene":["SCA","metalloproteases"],"gene_indices_start":[0,59],"gene_indices_end":[3,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6410,"text":"A pyrazolo-quinoline compound , 6-methoxy-4- [ 2- [ ( 2-hydroxyethoxyl ) -ethyl ] amino ] -3-methyl-1M-pyrazo lo [ 3 , 4-b ] quinoline ( SCH 51344 ) , was identified based on its ability to derepress human smooth muscle alpha-actin promoter activity in ras-transformed cells .","gene":["alpha-actin promoter"],"gene_indices_start":[220],"gene_indices_end":[240],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6413,"text":"Epstein-Barr virus nuclear protein 2 ( EBNA2 ) binds to a component of the human SNF-SWI complex , hSNF5 \/ Ini1 .","gene":["Epstein-Barr virus nuclear protein 2 ( EBNA2 )","hSNF5","Ini1","human SNF-SWI complex"],"gene_indices_start":[0,75,99,107],"gene_indices_end":[46,96,104,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6416,"text":"METHODS : rHb1 . 1 or human serum albumin was administered intravenously to fasting male volunteers .","gene":["human serum albumin","rHb1 . 1"],"gene_indices_start":[10,22],"gene_indices_end":[18,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6417,"text":"EsaR can repress its own expression but seems not to regulate the expression of esaI .","gene":["EsaR","esaI"],"gene_indices_start":[0,80],"gene_indices_end":[4,84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6419,"text":"In the course of investigating the mechanisms by which OF5 and OF3 regulated CYP11A1 transcription , we found that OF5 and OF3 bound Sp1 and Sp3 in JEG-3 cells .","gene":["OF3","OF3","Sp3","OF5","Sp1","OF5","CYP11A1"],"gene_indices_start":[55,63,77,115,123,133,141],"gene_indices_end":[58,66,84,118,126,136,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6420,"text":"The TEA1 ( Ty enhancer activator ) gene sequence predicts a protein of 86 . 9 kDa whose N terminus contains a zinc cluster and dimerization motif typical of the Gal4-type family of DNA-binding proteins .","gene":["Ty enhancer activator","Gal4-type family","TEA1"],"gene_indices_start":[4,11,161],"gene_indices_end":[8,32,177],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6423,"text":"The genomic fragments were fused upstream of the luciferase reporter gene .","gene":["luciferase reporter gene"],"gene_indices_start":[49],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6428,"text":"Further studies established that the Ep-induced increase in beta-globin mRNA could be inhibited by the tyrosine kinase inhibitor genistein and the protein kinase C inhibitor Compound 3 . ( ABSTRACT TRUNCATED AT 250 WORDS )","gene":["beta-globin mRNA","tyrosine kinase","protein kinase C"],"gene_indices_start":[60,103,147],"gene_indices_end":[76,118,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6434,"text":"Cells containing alpha subunits that lacked a distal domain ( term-3 ) or had the alternatively spliced alpha-2 distal domain showed markedly decreased ability to support tyrosine phosphorylation of Jak-2 and its substrates or to up-regulate CD86 .","gene":["Jak-2","CD86","term-3","alpha-2 distal domain","distal"],"gene_indices_start":[46,62,104,199,242],"gene_indices_end":[52,68,125,204,246],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6435,"text":"Consistent with this possibility , a non-MBD region of Bin1 was sufficient to recruit a repression function to DNA that was unrelated to histone deacetylase .","gene":["histone deacetylase","Bin1"],"gene_indices_start":[55,137],"gene_indices_end":[59,156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6437,"text":"Addition of Rap or KN62 after exposure of cells to progesterone agonist Org 2058 had no effect on induction of CAT activity .","gene":["CAT"],"gene_indices_start":[111],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6442,"text":"E2F -1 is a transcription factor that regulates cell cycle progression into S-phase .","gene":["E2F -1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6444,"text":"Transactivation of oIFNtau enhancer-reporter constructs was primarily regulated by three regions containing AP-1 site , GATA like sequence and site ( s ) unidentified .","gene":["GATA","oIFNtau","AP-1 site"],"gene_indices_start":[19,108,120],"gene_indices_end":[26,117,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6445,"text":"Interestingly , continuation of the interferon therapy in the presence of a mild-to-moderate exacerbation of sarcoidosis may be safe in a minority of patients with noncritical organ involvement .","gene":["interferon"],"gene_indices_start":[36],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6447,"text":"Transfection analyses indicate that mutation of any one of these TGACCT motifs or truncation of the entire HD PPRE into a separate DR1 and DR2 element significantly reduced the transcriptional response of HD PPRE to peroxisome proliferators .","gene":["TGACCT motifs","PPRE","HD","DR2 element","DR1","HD","PPRE"],"gene_indices_start":[65,107,110,131,139,205,208],"gene_indices_end":[78,109,114,134,150,207,212],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6448,"text":"The amino acid changes D206A and D208A abolish singly or in combination the exonuclease activity in vivo .","gene":["exonuclease"],"gene_indices_start":[76],"gene_indices_end":[87],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6451,"text":"There occurred a linear relationship between the drop in glucose-6-phosphatase dehydrogenase activity and in vitamin E level , on one hand , and the duration of poisoning with sodium nitrite .","gene":["glucose-6-phosphatase dehydrogenase"],"gene_indices_start":[57],"gene_indices_end":[92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6452,"text":"A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene .","gene":["angiotensinogen gene"],"gene_indices_start":[141],"gene_indices_end":[161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6453,"text":"Hepatic oxygen supply and selected blood parameters were recorded in fasted male rates given 20--30 mg \/ kg Escherichia coli endotoxin intraperitoneally .","gene":["Escherichia coli endotoxin"],"gene_indices_start":[108],"gene_indices_end":[134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6456,"text":"We propose that Gly84 is part of a putative \"oxyanion hole\" involved in the stabilization of the transition state similar to the C group of the esterase \/ lipase family .","gene":["C group","esterase","lipase"],"gene_indices_start":[129,144,155],"gene_indices_end":[136,152,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6457,"text":"While important for ligand-dependent transactivation , this interaction surface is not directly involved in transrepression of AP-1 activity .","gene":["AP-1"],"gene_indices_start":[127],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6460,"text":"Their function is not only to recruit Pho2 to the promoter but to allow cooperative binding of Pho4 together with Pho2 .","gene":["Pho2","Pho2","Pho4"],"gene_indices_start":[38,95,114],"gene_indices_end":[42,99,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6461,"text":"EUK-8 is a novel , synthetic , low-molecular-weight salen-manganese complex that exhibits both superoxide dismutase and catalase activities in vitro .","gene":["catalase","superoxide dismutase"],"gene_indices_start":[95,120],"gene_indices_end":[115,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6462,"text":"Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors .","gene":["Ras p21Val","myogenic basic helix-loop-helix factors"],"gene_indices_start":[0,101],"gene_indices_end":[10,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6463,"text":"The patient underwent two intracytoplasmic sperm injection cycles with thawed epididymal spermatozoa , in which , due to a pharmacist's mistake , ovarian stimulation was carried out by a combination of long-acting gonadotrophin-releasing hormone agonist ( leuprolide depot ) and gonadotrophins .","gene":["gonadotrophins","gonadotrophin-releasing hormone"],"gene_indices_start":[214,279],"gene_indices_end":[245,293],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6464,"text":"In F42A-stimulated internalization assays on forskolin-induced YT-1 cells , the IL-2R alpha chain is consistently endocytosed together with the IL-2R beta subunit indicating that IL-2R alpha is stably associated with the F42A-IL-2R beta complex even though the alpha-subunit contributes little if any affinity to the F42A binding reaction .","gene":["IL-2R beta subunit","F42A","F42A-IL-2R beta complex","IL-2R alpha","IL-2R alpha chain"],"gene_indices_start":[80,144,179,221,317],"gene_indices_end":[97,162,190,244,321],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6465,"text":"These findings suggest that an intracellular WT1 \/ Hsal 2 pathway may play a role in development and hematopoiesis .","gene":["intracellular WT1 \/ Hsal 2"],"gene_indices_start":[31],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6468,"text":"In contrast to T cells , in fibroblasts PILOT gene expression requires only one signal ( PMA ) and is not affected by CyA .","gene":["PILOT gene"],"gene_indices_start":[40],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6469,"text":"Similar experiments with TR support the high affinity of RIP140 to the RXR subunit and also suggest that either partner in the TR \/ RXR heterodimer can independently respond to ligand .","gene":["RIP140","TR","RXR subunit","TR \/ RXR heterodimer"],"gene_indices_start":[25,57,71,127],"gene_indices_end":[27,63,82,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6470,"text":"The findings are compatible with the idea that the genes encoding PDGF receptors in glioma cells are regulated in concert with other genes , the expression of which may reflect the developmental program of normal glia cell lineages .","gene":["PDGF receptors"],"gene_indices_start":[66],"gene_indices_end":[80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6472,"text":"Several genes or transcriptional units were identified , including the 3' end of ribosomal s6 kinase ( Rsk3 ) ; two apparently intronless and ORF-less genes ; and Gpr31 , an intronless , putative G-protein coupled receptor .","gene":["Rsk3","G-protein coupled receptor","Gpr31","ribosomal s6 kinase"],"gene_indices_start":[81,103,163,196],"gene_indices_end":[100,107,168,222],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6473,"text":"Using gel retardation assays with HepG2 nuclear extract , we demonstrated the presence of a specific protein which bound to the NRE fragment .","gene":["NRE"],"gene_indices_start":[128],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6474,"text":"Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes .","gene":["Xenopus homolog of the mos protooncogene"],"gene_indices_start":[0],"gene_indices_end":[40],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6476,"text":"Here , we describe a tyrosine-phosphorylated nuclear protein , YT521-B , and show that it interacts with the nuclear transcriptosomal component scaffold attachment factor B , and the 68-kDa Src substrate associated during mitosis , Sam68 .","gene":["Sam68","nuclear transcriptosomal component scaffold attachment factor B","YT521-B","68-kDa Src"],"gene_indices_start":[63,109,183,232],"gene_indices_end":[70,172,193,237],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6477,"text":"The exon : intron structure of chicken IL8 corresponds almost exactly to that of human IL8 and differs from those of other known mammalian CXC chemokine genes .","gene":["chicken IL8","human IL8","mammalian CXC chemokine genes"],"gene_indices_start":[31,81,129],"gene_indices_end":[42,90,158],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6478,"text":"Brain scan with 99mTc-labelled macroaggregated albumin ( MAA brain scan ) and computed tomography studies ( CT ) were performed on 78 patients with intracranial diseases .","gene":["albumin"],"gene_indices_start":[47],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6481,"text":"Tumor cells were focally immunoreactive for neuron-specific enolase , insulin , glucagon and VIP .","gene":["insulin","glucagon","VIP","neuron-specific enolase"],"gene_indices_start":[44,70,80,93],"gene_indices_end":[67,77,88,96],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6482,"text":"Analysis of viral mutants in vivo demonstrated that the NFIII \/ OCT-1 binding site and a conserved ATF motif were important for efficient viral growth .","gene":["NFIII","ATF motif"],"gene_indices_start":[56,99],"gene_indices_end":[61,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6483,"text":"E1A autoactivation mediated by these sites was about twofold compared with a ninefold activation described for the complete E1A promoter .","gene":["E1A promoter","E1A"],"gene_indices_start":[0,124],"gene_indices_end":[3,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6484,"text":"We report here the molecular cloning of a putative adhesive molecule from P . falciparum that shares both sequence and structural similarities with a sporozoite surface molecule from Plasmodium termed the thrombospondin-related anonymous protein ( TRAP ) and , to a lesser extent , with the circumsporozoite ( CS ) protein .","gene":["thrombospondin-related anonymous protein","TRAP"],"gene_indices_start":[205,248],"gene_indices_end":[245,252],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6486,"text":"The epitope-protected lysine ( K ) was present in a 30-aa TPO fragment that , by N-terminal sequencing , was found to be K713 .","gene":["30-aa TPO fragment"],"gene_indices_start":[52],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6490,"text":"Samples from 1415 neurological patients were used to study the diagnostic value of acid alpha 1-glycoprotein in the lumbar cerebrospinal fluid .","gene":["acid alpha 1-glycoprotein"],"gene_indices_start":[83],"gene_indices_end":[108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6491,"text":"In addition , a comparison of the hCHLR gene sequences with available databases indicates that a large portion of these genes , including exons encoding two functional domains of the carboxyl-terminal region of these proteins , has been duplicated as part of a larger human telomeric repeat sequence found on many human chromosomes .","gene":["hCHLR gene sequences"],"gene_indices_start":[34],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6493,"text":"Moreover , increasing the dosage of wild-type Fus3 intensifies the inhibition of both Ty1 transposition and invasive growth .","gene":["Ty1","wild-type Fus3"],"gene_indices_start":[36,86],"gene_indices_end":[50,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6494,"text":"Type 2 deiodinase ( D2 ) catalyzes the 5'-deiodination of thyroxine to form 3 , 5 , 3'-triiodothyronine .","gene":["D2","Type 2 deiodinase"],"gene_indices_start":[0,20],"gene_indices_end":[17,22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6495,"text":"Comparison of genomic sequence shows that the ph locus has been duplicated , and that it contains proximal and distal transcription units .","gene":["ph locus"],"gene_indices_start":[46],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6498,"text":"Phosphopeptide mapping revealed the same autophosphorylation sites utilized by EGFR-IC as those identified in wild-type EGFR .","gene":["EGFR-IC","wild-type EGFR"],"gene_indices_start":[79,110],"gene_indices_end":[86,124],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6500,"text":"Induction of CD86 expression by stimulation of U937 cells with IFN-gamma revealed the presence of two functional GAS ( gamma-interferon activation site ) elements .","gene":["IFN-gamma","CD86","GAS","gamma-interferon activation site"],"gene_indices_start":[13,63,113,119],"gene_indices_end":[17,72,116,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6504,"text":"These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex .","gene":["HDAC complex","Ski","Ski"],"gene_indices_start":[24,50,72],"gene_indices_end":[27,62,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6506,"text":"The structural genes encoding glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ) , 3-phosphoglycerate kinase ( PGK ) and the N-terminal part of triosephosphate isomerase ( TIM ) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster ( gap operon ) by complementation of an Escherichia coli gap amber mutant .","gene":["3-phosphoglycerate kinase","gap operon","glyceraldehyde-3-phosphate dehydrogenase","gap amber mutant","PGK","triosephosphate isomerase","GAPDH","TIM"],"gene_indices_start":[30,73,83,111,144,172,258,313],"gene_indices_end":[70,78,108,114,169,175,268,329],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6507,"text":"An E box element is required for the expression of the ad4bp gene , a mammalian homologue of ftz-f1 gene , which is essential for adrenal and gonadal development .","gene":["ad4bp gene","mammalian homologue of ftz-f1 gene"],"gene_indices_start":[55,70],"gene_indices_end":[65,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6508,"text":"1- ( m-Chlorophenyl ) piperazine ( mCPP , 0 . 1-3 . 0 mg \/ kg ) and 1- ( m-trifluoromethylphenyl ) piperazine ( TFMPP , 0 . 1-3 . 0 mg \/ kg ) , both thought to act primarily at 5-HT1 sites , also decreased responding and this effect was blocked by methysergide and by 1-NP , but not by ketanserin .","gene":["5-HT1 sites"],"gene_indices_start":[177],"gene_indices_end":[188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6511,"text":"Ang II-induced fibronectin mRNA was not affected by PKC inhibitors or PKC depletion , whereas specific inhibition of EGF-R function by a dominant negative EGF-R mutant and tyrphostin AG1478 abolished induction of fibronectin mRNA .","gene":["PKC","EGF-R","PKC","dominant negative EGF-R mutant","fibronectin mRNA","Ang II-induced fibronectin mRNA"],"gene_indices_start":[0,52,70,117,137,213],"gene_indices_end":[31,55,73,122,167,229],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6514,"text":"Coliphage 186 B is a 72-amino acid protein belonging to the Ogr family of analogous transcription factors present in P2-like phage , which contain a Cys-X2-Cys-X22-Cys-X4-Cys presumptive zinc-finger motif .","gene":["Ogr","Coliphage 186 B"],"gene_indices_start":[0,60],"gene_indices_end":[15,63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6516,"text":"Vac1p was found to bind the Sec1p homologue Vps45p .","gene":["Vps45p","Sec1p homologue","Vac1p"],"gene_indices_start":[0,28,44],"gene_indices_end":[5,43,50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6517,"text":"Interspecific complementation tests showed that the P7 proteins are unable to complement P1 parA or parB mutants , and the P1 proteins fail to complement the P7 mutations .","gene":["P7 mutations","P1 proteins","parB mutants","P1 parA","P7 proteins"],"gene_indices_start":[52,89,100,123,158],"gene_indices_end":[63,96,112,134,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6518,"text":"The Aie1 locus was mapped to mouse chromosome 7A2-A3 by fluorescent in situ hybridization .","gene":["Aie1 locus"],"gene_indices_start":[4],"gene_indices_end":[14],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6522,"text":"Erratum to \"Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects : a study based on coronary angiography\" .","gene":["\"Cholesteryl ester transfer protein"],"gene_indices_start":[11],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6524,"text":"The concentrations of plasma ACTH and cortisol increased by 40% and 60% after MPTP treatment , respectively .","gene":["ACTH"],"gene_indices_start":[29],"gene_indices_end":[33],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6526,"text":"Only two of the isoforms possess the N-terminal zinc finger domain that is necessary and sufficient for TdT promoter binding .","gene":["TdT promoter"],"gene_indices_start":[104],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6527,"text":"RT-PCR indicated that p21 mRNA was induced 1 . 4- , 2 . 0- , and 3 . 1-fold in the 2-day neonatal , 7-day neonatal , and adult stages , respectively , compared to the 17-day fetal stage .","gene":["p21 mRNA"],"gene_indices_start":[22],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6529,"text":"Three-dimensional structural studies using electron cryomicroscopy showed that the binding of one Fab ( 8H2 \/ G5 ) does not affect the conformation of the capsid , and the efficiency of mRNA production is similar to that of the native subviral particle .","gene":["Fab"],"gene_indices_start":[98],"gene_indices_end":[101],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6536,"text":"She improved with a combination of benzodiazepines and the acetylcholinesterase inhibitor physostigmine .","gene":["acetylcholinesterase"],"gene_indices_start":[59],"gene_indices_end":[79],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6537,"text":"Platelet activating factor was given in six doses at 15 minute intervals and airway response measured as change in partial expiratory flow at 30% of vital capacity ( Vp30 ) .","gene":["Platelet activating factor"],"gene_indices_start":[0],"gene_indices_end":[26],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6539,"text":"Since we have observed effects of growth factors and cAMP as well as estradiol ( E2 ) on regulation of expression of some genes stimulated by the estrogen receptor ( ER ) , we have undertaken studies to examine directly whether activators of protein kinases can modulate transcriptional activity of the ER .","gene":["ER","growth factors","ER","estrogen receptor","protein kinases"],"gene_indices_start":[34,146,166,242,303],"gene_indices_end":[48,163,168,257,305],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6540,"text":"BCL-2 , an inhibitor of apoptosis in a wide variety of cell types , has been reported to prevent oxidative stress-induced cell death .","gene":["BCL-2"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6542,"text":"Mature tobacco L12 protein has 44% amino acid identity with ribosomal protein L7 \/ L12 of Escherichia coli .","gene":["ribosomal protein L7 \/ L12 of Escherichia coli","Mature tobacco L12 protein"],"gene_indices_start":[0,60],"gene_indices_end":[26,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6544,"text":"On the other side , when the aortic ring was perfused with L-NNA ( NO-synthesis inhibitor ) or methylene blue ( soluble cGMPase inhibitor ) , the changes could be attenuated .","gene":["cGMPase"],"gene_indices_start":[120],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6550,"text":"Replication of bovine papillomavirus-1 ( BPV-1 ) DNA requires two viral gene products , the E1 protein and the full-length E2 protein .","gene":["E1 protein","full-length E2 protein"],"gene_indices_start":[92,111],"gene_indices_end":[102,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6552,"text":"The gene encoding human tissue-type plasminogen activator ( t-PA ) is regulated in a cell-type-specific manner .","gene":["gene encoding human tissue-type plasminogen activator","t-PA"],"gene_indices_start":[4,60],"gene_indices_end":[57,64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6553,"text":"One month after the DTaP booster vaccination , both groups had 6- to 40-fold increases in serum antibody concentrations to all antigens tested ; the concentrations against the three pertussis antigens were higher in the DTaP-primed children ( p < 0 . 05 ) .","gene":["pertussis antigens"],"gene_indices_start":[182],"gene_indices_end":[200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6554,"text":"The iron dependence of transcription and expression of cvaA , which encodes a transporter accessory protein , and cvi , encoding the colicin V immunity protein , was assessed under conditions of iron excess or depletion .","gene":["cvi","colicin V immunity protein","cvaA"],"gene_indices_start":[55,114,133],"gene_indices_end":[59,117,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6555,"text":"Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor ( GHS-R ) .","gene":["GHS-R","orphan GH-secretagogue receptor","GH"],"gene_indices_start":[85,122,156],"gene_indices_end":[87,153,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6556,"text":"Self-heating after deep hypothermia ( 20 degrees C ) causes a considerable increase in the brain tissues glutaminase activity at all studied incubation temperatures ( 37 , 30 , 20 and 10 degrees C ) as compared to control rats and rats under hypothermia .","gene":["glutaminase"],"gene_indices_start":[105],"gene_indices_end":[116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6559,"text":"We also show that in fusions with the DNA binding domain of GAL4 , full activity requires the entire BHV-alpha TIF , although both amino and carboxyl termini display some activity on their own .","gene":["GAL4","BHV-alpha TIF"],"gene_indices_start":[60,101],"gene_indices_end":[64,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6560,"text":"Effects of a booster dose of tetanus toxoid after different primary courses of vaccination : implications on the use of immune globulin .","gene":["immune globulin"],"gene_indices_start":[120],"gene_indices_end":[135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6561,"text":"In Xenopus , BMPs act as epidermal inducers and also as negative regulators of neurogenesis .","gene":["BMPs"],"gene_indices_start":[13],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6563,"text":"Characterization of fus1 of Schizosaccharomyces pombe : a developmentally controlled function needed for conjugation .","gene":["fus1"],"gene_indices_start":[20],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6564,"text":"Southern analysis on genomic DNA isolated from tissues and cell lines from several mouse strains using mCD22 cDNA demonstrated that the Cd22 locus encoding mCD22 is a single copy gene of < or = 30 kb .","gene":["mCD22 cDNA","Cd22 locus","mCD22"],"gene_indices_start":[103,136,156],"gene_indices_end":[113,146,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6568,"text":"Therefore , we conclude that DnaA may contact the beta subunit of RNA polymerase during activation of the pR promoter .","gene":["pR promoter","RNA polymerase","DnaA"],"gene_indices_start":[29,66,106],"gene_indices_end":[33,80,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6570,"text":"Fourth , the 3'-region splice junctions of the MSRs during latent and productive infection were determined by sequencing RNA-PCR products generated with primers that flank the 3' splice region .","gene":["MSRs"],"gene_indices_start":[47],"gene_indices_end":[51],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6573,"text":"Treatment of hypertension with a combination of the adrenergic beta receptor blockader , obsidan , and the vasodilator , apressin .","gene":["adrenergic beta receptor"],"gene_indices_start":[52],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6574,"text":"The results of these studies demonstrate that the rat HDL receptor SR-BI promoter contains two sterol response elements ( pSRE and dSRE ) through which SREBP-1a can bind and activate transcription of this gene .","gene":["pSRE","SREBP-1a","rat HDL receptor SR-BI promoter","sterol response elements","dSRE"],"gene_indices_start":[50,95,122,131,152],"gene_indices_end":[81,119,126,135,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6575,"text":"Disruption demonstrates that CDC14 is an essential gene .","gene":["CDC14"],"gene_indices_start":[29],"gene_indices_end":[34],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6577,"text":"Further support for a direct interaction of Tub4p , Spc98p and Spc97p comes from the toxicity of strong SPC97 overexpression which is suppressed by co-overexpression of TUB4 or SPC98 .","gene":["Spc98p","Spc97p","SPC97","TUB4","SPC98","Tub4p"],"gene_indices_start":[44,52,63,104,169,177],"gene_indices_end":[49,58,69,109,173,182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6579,"text":"Our previous studies have shown that SHP-1 , a SH2 domain-containing protein-tyrosine phosphatase , is expressed not only in cells of hematopoietic lineages , but also in many non-hematopoietic cells under the control of an alternative tissue-specific promoter , P1 .","gene":["SH2 domain-containing protein-tyrosine phosphatase","SHP-1","P1"],"gene_indices_start":[37,47,263],"gene_indices_end":[42,97,265],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6582,"text":"The Y-type structural motif is also conserved among a number of divergent BiP mRNAs .","gene":["Y-type structural motif","BiP mRNAs"],"gene_indices_start":[4,74],"gene_indices_end":[27,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6584,"text":"Potentiation of the thrombolytic efficacy of single-chain urokinase ( Pro-urokinase ) by heparin .","gene":["Pro-urokinase","single-chain urokinase"],"gene_indices_start":[45,70],"gene_indices_end":[67,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6585,"text":"Effect of biliary obstruction and cholangitis on serum SPan-1 level .","gene":["serum SPan-1"],"gene_indices_start":[49],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6586,"text":"The overexpressed His6-tagged GrsA derivatives were affinity-purified , and the catalytic properties of the deletion mutants were examined by biochemical studies including ATP-dependent amino acid activation , carboxyl thioester formation , and the ability to racemize the covalently bound phenylalanine from L- to the D-isomer .","gene":["His6-tagged GrsA derivatives"],"gene_indices_start":[18],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6587,"text":"Induction requires the ACE1 gene product , which binds to specific sites in the promoter region of the CUP1 gene .","gene":["ACE1 gene product","CUP1 gene"],"gene_indices_start":[23,103],"gene_indices_end":[40,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6593,"text":"Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides .","gene":["S100 protein"],"gene_indices_start":[59],"gene_indices_end":[71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6596,"text":"Alignment of the amino acid sequences surrounding Tyr-766 with corresponding regions of other FGFRs revealed conserved tyrosine residues in all known members of the FGFR family .","gene":["FGFR family","FGFRs"],"gene_indices_start":[94,165],"gene_indices_end":[99,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6597,"text":"Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor ( GEF ) .","gene":["guanine nucleotide exchange factor","Mss4","GEF"],"gene_indices_start":[0,43,80],"gene_indices_end":[4,77,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6599,"text":"Some artificial promoter constructs containing multiple Sp1 sites were highly responsive to ethanol , but others were not , suggesting that the organization of the proximal promoter region was an additional factor that affected the ethanol response .","gene":["Sp1 sites"],"gene_indices_start":[56],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6600,"text":"Polysome and 40S ribosome fractions were severely decreased in the krr1 mutant and Kri1p-depleted cells .","gene":["Polysome","40S ribosome","krr1 mutant"],"gene_indices_start":[0,13,67],"gene_indices_end":[8,25,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6601,"text":"The alpha 4 gene 5' flanking region acted as a promoter in transfection assays .","gene":["alpha 4 gene"],"gene_indices_start":[4],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6606,"text":"Delineating the molecular basis for agonist-induced destabilization of mRNA of G-protein-linked receptors that contributes to receptor down-regulation is fundamental to our understanding of long-term regulation of receptors by agonist .","gene":["G-protein-linked receptors"],"gene_indices_start":[79],"gene_indices_end":[105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6607,"text":"The cloned alcR gene provided in trans restored these siderophore system activities to the mutants .","gene":["alcR gene"],"gene_indices_start":[11],"gene_indices_end":[20],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6609,"text":"We conclude that the gp54 structural gene is required for initiation or amplification of the splenic erythroblast hyperplasia which characterizes the preleukemic phase of Rauscher disease .","gene":["gp54 structural gene"],"gene_indices_start":[21],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6612,"text":"Transcription of the first operon coding for m-xylene-degrading enzymes on the TOL plasmid of Pseudomonas putida is activated by the xylR gene product in the presence of m-xylene .","gene":["xylR gene product"],"gene_indices_start":[133],"gene_indices_end":[150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6616,"text":"MDBP from HeLa and Raji cells formed DNA-protein complexes with X-box oligonucleotides that coelectrophoresed with those containing standard MDBP sites .","gene":["MDBP sites","MDBP"],"gene_indices_start":[0,141],"gene_indices_end":[4,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6619,"text":"The insulin therapy regimen did not affect the evolution of the patients and no significant relationship existed between the age at diagnosis , duration of diabetes , daily insulin dosage or metabolic control and height or BMI .","gene":["insulin","insulin"],"gene_indices_start":[4,173],"gene_indices_end":[11,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6621,"text":"As in mammals , considerable nucleotide diversity was observed at the junctions of the variable , diversity , and joining elements in chicken TCR beta cDNAs .","gene":["chicken TCR beta cDNAs"],"gene_indices_start":[134],"gene_indices_end":[156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6622,"text":"Two alternatively spliced 5' UTRs , designated type I and type II , of 222 and 115 bp , respectively , were found associated with PFP .","gene":["PFP"],"gene_indices_start":[130],"gene_indices_end":[133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6623,"text":"Our data , combined with those of Hershey and co-workers , suggest that mammalian eIF3 is composed of at least 10 subunits : p170 , p116 ( hPrt1 ) , p110 , p66 , p48 , p47 , p44 , p40 , p36 , and p35 .","gene":["p35","p44","p36","p170","hPrt1","p110","p66","mammalian eIF3","p47","p40","p116","p48"],"gene_indices_start":[72,125,132,139,149,156,162,168,174,180,186,196],"gene_indices_end":[86,129,136,144,153,159,165,171,177,183,189,199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6624,"text":"A controlled trial of recombinant human granulocyte-macrophage colony-stimulating factor after total body irradiation , high-dose chemotherapy , and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma .","gene":["recombinant human granulocyte-macrophage colony-stimulating factor"],"gene_indices_start":[22],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6629,"text":"Gaucher's disease is a rare metabolic disorder characterized by the lack of beta-glucocerebrosidase enzyme .","gene":["beta-glucocerebrosidase enzyme"],"gene_indices_start":[76],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6632,"text":"The NIT2 protein is localised in nuclei and could not be detected in the cytoplasmic fraction of cells subjected to nitrogen derepression or nitrogen repression , indicating that the nuclear import of NIT2 is not regulated .","gene":["NIT2 protein","NIT2"],"gene_indices_start":[4,201],"gene_indices_end":[16,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6636,"text":"Promoter analysis demonstrated that the sequence identical to consensus cAMP-responsive element ( CRE ) located at -481 of the SMemb promoter was critical for Hex responsiveness .","gene":["Hex","consensus cAMP-responsive element","CRE","SMemb promoter"],"gene_indices_start":[62,98,127,159],"gene_indices_end":[95,101,141,162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6638,"text":"Transfection of increasing amounts of delta5ERalpha expression vector into [ ERalpha+ ] OS cells resulted in potentiation of E2-stimulated ERELuc activity in a synergistic , dose-dependent manner .","gene":["ERELuc","delta5ERalpha"],"gene_indices_start":[38,139],"gene_indices_end":[51,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6641,"text":"By introducing a series of deletions in the vimentin promoter , we further restrict these sequences to 30 base pairs , located between 241 and 210 base pairs upstream of the mRNA cap site .","gene":["vimentin"],"gene_indices_start":[44],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6642,"text":"Transformation of the sconC3 mutant with sconB+ restores the wild-type phenotype .","gene":["sconC3 mutant","sconB+"],"gene_indices_start":[22,41],"gene_indices_end":[35,47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6643,"text":"We have attempted to clone two recessive extragenic suppressors of such ts mutants ( sdp1 for mutation pol3-14 and sdp5-1 for mutation pol3-11 ) by transforming thermoresistant haploid strains pol3-14 sdp1 and pol3-11 sdp5-1 with wild-type genomic libraries in singlecopy or multicopy vectors .","gene":["mutation pol3-14","pol3-11 sdp5-1","mutation pol3-11","pol3-14 sdp1"],"gene_indices_start":[94,126,193,210],"gene_indices_end":[110,142,205,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6644,"text":"Alternative splicing of CDC25B may therefore contribute to the control of cell proliferation .","gene":["CDC25B"],"gene_indices_start":[24],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6647,"text":"Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes .","gene":["alpha 1-fetoprotein gene"],"gene_indices_start":[89],"gene_indices_end":[113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6648,"text":"The terminator region supported termination of transcripts initiated by RNA polymerase I in vivo .","gene":["RNA polymerase I"],"gene_indices_start":[72],"gene_indices_end":[88],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6649,"text":"The level of the SUP4A53T61 transcript was threefold higher in the tap1-1 mutant than in the wild type .","gene":["tap1-1 mutant","SUP4A53T61 transcript"],"gene_indices_start":[17,67],"gene_indices_end":[38,80],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6654,"text":"The data indicates the presence of 5-HT2 serotonergic receptors in the bronchial artery of these species .","gene":["5-HT2 serotonergic receptors"],"gene_indices_start":[35],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6657,"text":"This study shows that C \/ EBPbeta is the predominant C \/ EBP isoform found in activated stellate cells and that increased C \/ EBPbeta protein and C \/ EBPbeta binding to a proximal C \/ EBP binding site in the promoter mediates the activating effect of acetaldehyde .","gene":["C \/ EBPbeta","C \/ EBPbeta protein","C \/ EBP binding site","C \/ EBP isoform","C \/ EBPbeta"],"gene_indices_start":[22,53,122,146,180],"gene_indices_end":[33,68,141,157,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6659,"text":"Hence temperature and virF are both required for the induction of the yop regulon .","gene":["virF","yop regulon"],"gene_indices_start":[22,70],"gene_indices_end":[26,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6660,"text":"However , it is not known whether the recently identified isoforms Vav2 and Vav3 , which are broadly expressed , can couple with similar classes of receptors , nor is it known whether all Vav isoforms possess identical functional activities .","gene":["Vav isoforms","Vav3","Vav2"],"gene_indices_start":[67,76,188],"gene_indices_end":[71,80,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6662,"text":"Two distinct recessive susceptibility loci for vasculitis were mapped on chromosome ( Chr ) 4 at D4Mit89 and D4Mit147 in both progenies .","gene":["D4Mit89","D4Mit147"],"gene_indices_start":[97,109],"gene_indices_end":[104,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6663,"text":"These cell lines , selected for the ability to support the replication of a temperature-sensitive VP5 mutant , were used to isolate VP5 and VP23 null mutants .","gene":["VP5","VP23","VP5 mutant"],"gene_indices_start":[98,132,140],"gene_indices_end":[108,135,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6667,"text":"The Cut9 subunit is likely to be a target for regulating APC \/ cyclosome function through protein-protein interactions and phosphorylation .","gene":["APC \/ cyclosome","Cut9 subunit"],"gene_indices_start":[4,57],"gene_indices_end":[16,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6669,"text":"We have examined the role of two recombination- and repair-defective mutations , rad1 and rad52 , on direct repeat recombination in transcriptionally active and inactive sequences .","gene":["rad1","rad52"],"gene_indices_start":[81,90],"gene_indices_end":[85,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6670,"text":"The following markers were looked for in the serum , skin and liver of all patients with chronic hepatitis : HBV ( HBs Ag and HBe Ag , anti-HBs , anti-HBe and anti-HBc in the serum , HBs and HBc Ag in the liver ) ; non-A non-B ( non-A , non-B Ag and antibody , anti non-A non-Bc in the serum , non-A , non-Bc Ag in the liver ) .","gene":["anti non-A non-Bc","anti-HBe","anti-HBs","anti-HBc"],"gene_indices_start":[135,146,159,261],"gene_indices_end":[143,154,167,278],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6671,"text":"The harpin-encoding hrpZ gene is located in an operon that also encodes Hrp secretion pathway components and is part of the functional cluster of hrp genes carried on cosmid pHIR11 that enables saprophytic bacteria like Escherichia coli and Pseudomonas fluorescens to elicit the HR in tobacco leaves .","gene":["hrp genes","hrpZ gene","Hrp secretion pathway components"],"gene_indices_start":[20,72,146],"gene_indices_end":[29,104,155],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6673,"text":"We present here a detailed genomic sequencing analysis of the cytosine methylation patterns of the transposase binding sites within both Ac ends in the wx-m9 : : Ac allele , where Ac is inserted into the tenth exon of the Waxy gene .","gene":["Waxy gene","Ac","wx-m9","Ac","Ac allele"],"gene_indices_start":[137,152,162,180,222],"gene_indices_end":[139,157,171,182,231],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6675,"text":"Expression of herpes simplex virus type 2 US3 affects the Cdc42 \/ Rac pathway and attenuates c-Jun N-terminal kinase activation .","gene":["herpes simplex virus type 2 US3","Cdc42","Rac","c-Jun N-terminal kinase"],"gene_indices_start":[14,58,66,93],"gene_indices_end":[45,63,69,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6678,"text":"Thus , the positive effect of NS1 on the steady-state levels of P4 transcripts depends on the amplification of gene copy number and the integrity of the terminal repeats .","gene":["NS1","P4 transcripts"],"gene_indices_start":[30,64],"gene_indices_end":[33,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6679,"text":"However , the requirement of rev3 for the production of G . C-- > T . A transversions by the rad18 mutator , which induces only these substitutions , was similar to that for rad6-mediated G . C-- > T . A transversion .","gene":["rad18 mutator","rev3"],"gene_indices_start":[29,93],"gene_indices_end":[33,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6685,"text":"Serum insulin-like growth factor I ( IGF-I ) SD score increased from -2 . 2 and -4 . 2 in men and women , respectively , to 1 . 8 and -0 . 9 at 6 months and 0 . 8 and -0 . 7 at 12 months .","gene":["IGF-I","Serum insulin-like growth factor I"],"gene_indices_start":[0,37],"gene_indices_end":[34,42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6687,"text":"These human IFN-beta-transformed cell populations have acquired a low , constitutive production of human IFN , while replicating at a rate similar to that of untransformed cells and of cells transformed with the control vector carrying a human IFN-beta sequence encoding an inactive , mutated protein .","gene":["human IFN-beta sequence","human IFN"],"gene_indices_start":[99,238],"gene_indices_end":[108,261],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6691,"text":"The alternative exon introduces the novel carboxyl terminus and a new translation stop signal , while simultaneously converting the coding sequence for 40 carboxyl-terminal residues in CeCAT alpha into 3'-untranslated nucleotides .","gene":["CeCAT alpha"],"gene_indices_start":[185],"gene_indices_end":[196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6693,"text":"However , the serum TNF-a concentration decreased significantly in patients receiving pentoxifylline ( basal 623+ \/ -366 pg \/ ml ; 6th month 562+ \/ -358 pg \/ ml , p < 0 . 01 ) , but not in the control group .","gene":["serum TNF-a"],"gene_indices_start":[14],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6696,"text":"Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase ( MEK ) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1 .","gene":["mitogen-activated protein-extracellular signal-regulated kinase kinase","S6K2","MEK","S6K1"],"gene_indices_start":[31,104,136,177],"gene_indices_end":[101,107,140,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6699,"text":"The N-terminal amino acid sequence of Mop has sequence homology with DNA binding proteins .","gene":["Mop"],"gene_indices_start":[38],"gene_indices_end":[41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6700,"text":"A catalytic domain of eukaryotic DNA topoisomerase I .","gene":["eukaryotic DNA topoisomerase I"],"gene_indices_start":[22],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6704,"text":"Using an oligomer duplex 5'-A ( GGGTTA ) ( 5 ) -3' \/ 5'- ( TAACCC ) ( 5 ) T-3' as a template-primer , we show that both the Klenow fragment of Escherichia coli DNA polymerase I and HIV reverse transcriptase could expand telomere DNA sequences as well , giving products greater than the size of the template DNA .","gene":["Klenow fragment of Escherichia coli DNA polymerase I","HIV reverse transcriptase","5'-A ( GGGTTA ) ( 5 ) -3' \/ 5'- ( TAACCC ) ( 5 ) T-3'"],"gene_indices_start":[25,124,181],"gene_indices_end":[78,176,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6707,"text":"Constitutive phosphorylation of the CD30v protein was demonstrated by in vitro labeling with [ 32P ] .","gene":["CD30v protein"],"gene_indices_start":[36],"gene_indices_end":[49],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6709,"text":"Antithrombin III ( AT III ) is a plasma protein which acts as the principal inhibitor of thrombin and is a major modulator of intravascular coagulation .","gene":["AT III","Antithrombin III","thrombin"],"gene_indices_start":[0,19,89],"gene_indices_end":[16,25,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6711,"text":"These defects no doubt impair the folding and configuration necessary for normal processing of the AVP gene precursor .","gene":["AVP gene precursor"],"gene_indices_start":[99],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6712,"text":"The results presented here show that AR1 of the promoter-proximal CAP subunit was required for papBA transcription even in the absence of the histone-like protein H-NS .","gene":["papBA","CAP subunit","histone-like protein","AR1","H-NS"],"gene_indices_start":[37,66,95,142,163],"gene_indices_end":[40,77,100,162,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6713,"text":"In Ka13 cells , CoCl ( 2 ) stimulated expression of a luciferase reporter gene under the control of a 15-kilobase pair mouse ho-1 promoter ( pHO15luc ) .","gene":["15-kilobase pair mouse ho-1 promoter","luciferase reporter gene","pHO15luc"],"gene_indices_start":[54,102,141],"gene_indices_end":[78,138,149],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6714,"text":"Hybridization data indicate that 6F6 . 2 corresponds to the previously characterized m6F6 cDNA clone and that 6F6 . 1 and 6F6 . 3 , but not 6F6 . 2 , are adjacent to alpha-type genes .","gene":["6F6 . 2","m6F6 cDNA clone","6F6 . 2","alpha-type genes","6F6 . 3","6F6 . 1"],"gene_indices_start":[33,85,110,122,140,166],"gene_indices_end":[40,100,117,129,147,182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6717,"text":"The viral oncoprotein E1A inhibits NFAT-dependent transactivation in a p300-dependent manner .","gene":["viral oncoprotein E1A"],"gene_indices_start":[4],"gene_indices_end":[25],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6721,"text":"Genomic DNA clones containing the T-cell-specific human MAL gene were isolated .","gene":["T-cell-specific human MAL gene"],"gene_indices_start":[34],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6722,"text":"Hematopoietic growth factors have already had an enormous impact on transfusion practice by eliminating or reducing the need for red blood cell transfusions in a variety of anemic states characterized by an absolute or relative decrease in erythropoietin .","gene":["Hematopoietic growth factors","erythropoietin"],"gene_indices_start":[0,240],"gene_indices_end":[28,254],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6723,"text":"Increased blood pressure during CyA treatment was independent of circulating ET-1 levels .","gene":["ET-1"],"gene_indices_start":[77],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6724,"text":"An NF1-related vitellogenin activator element mediates transcription from the estrogen-regulated Xenopus laevis vitellogenin promoter .","gene":["Xenopus laevis vitellogenin promoter","NF1-related vitellogenin activator element"],"gene_indices_start":[3,97],"gene_indices_end":[45,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6725,"text":"Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intracellular proteins including a 120 kDa phosphoprotein that we identify as the proto-oncogene c-Cbl .","gene":["anti-CD2 mAb","proto-oncogene c-Cbl","human CD2"],"gene_indices_start":[14,46,189],"gene_indices_end":[23,58,209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6726,"text":"As an extension of our structural characterization of the exon-intron organization of the mouse Pkr gene , we now have isolated and characterized the mouse Pkr promoter region required for IFN-inducible transcription .","gene":["mouse Pkr promoter region","mouse Pkr gene"],"gene_indices_start":[90,150],"gene_indices_end":[104,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6727,"text":"Therefore the binding sites for liver-enriched factors , present in the hamster CYP7A1 proximal promoter in close vicinity and conserved between species , constitute a regulatory unit important for basal hepatic expression and tissue restriction of the action of hormones such as insulin .","gene":["hamster CYP7A1 proximal promoter","insulin"],"gene_indices_start":[72,280],"gene_indices_end":[104,287],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6728,"text":"Although antisperm antibodies are associated with infertility , many hospital laboratories do not test for these antibodies .","gene":["antisperm antibodies"],"gene_indices_start":[9],"gene_indices_end":[29],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6729,"text":"We demonstrated that , under serum-starved conditions , KMS-11 and OPM-2 cells express appreciable levels of phosphorylated FGFR3 mutants indicating a constitutive activation of the Y373C and K650E receptors ; the addition of the aFGF ligand further increased the level of receptor phosphorylation .","gene":["FGFR3 mutants","K650E receptors","Y373C","aFGF ligand"],"gene_indices_start":[124,182,192,230],"gene_indices_end":[137,187,207,241],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6731,"text":"Here we show that calpeptin inhibits tyrosine phosphatases , enhancing tyrosine phosphorylation particularly of paxillin .","gene":["calpeptin","tyrosine phosphatases","paxillin"],"gene_indices_start":[18,37,112],"gene_indices_end":[27,58,120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6732,"text":"We show here that the LIM domain homeobox protein isl-1 activates the rat amylin promoter in both fibroblast and islet cell lines .","gene":["isl-1","LIM domain","rat amylin promoter","homeobox protein"],"gene_indices_start":[22,33,50,70],"gene_indices_end":[32,49,55,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6733,"text":"The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels .","gene":["wild-type HIS4 mRNA","delta promoter insertion his-4-912 delta","spt2 mutations"],"gene_indices_start":[15,89,161],"gene_indices_end":[29,129,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6734,"text":"The Pro-258-- > Leu ( P258L ) mutation caused constitutive receptor signaling that was equivalent to about 45% of the maximum level observed in wild-type cells stimulated with alpha-factor .","gene":["alpha-factor"],"gene_indices_start":[176],"gene_indices_end":[188],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6736,"text":"A sterol-regulated protease initiates release of the NH2-terminal segments of sterol regulatory element-binding proteins ( SREBPs ) from cell membranes , thereby allowing them to enter the nucleus and to stimulate transcription of genes involved in the uptake and synthesis of cholesterol and fatty acids .","gene":["sterol regulatory element-binding proteins","sterol-regulated protease","SREBPs"],"gene_indices_start":[2,78,123],"gene_indices_end":[27,120,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6739,"text":"Cell survival by Epo did not require activation of other known signaling pathways including PI-3 kinase , PLC-gamma , Ras or Stats .","gene":["Ras","PLC-gamma","PI-3 kinase","Stats","Epo"],"gene_indices_start":[17,92,106,118,125],"gene_indices_end":[20,103,115,121,130],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6743,"text":"We have now identified , after 21 serial undiluted passages of MHV , a small DI RNA , DIssF , which is efficiently packaged into virions .","gene":["small DI RNA","DIssF"],"gene_indices_start":[71,86],"gene_indices_end":[83,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6744,"text":"No homology was found between RNA14 and RNA15 or between RNA14 and other proteins contained in data banks .","gene":["RNA14","RNA14","RNA15"],"gene_indices_start":[30,40,57],"gene_indices_end":[35,45,62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6746,"text":"E2F is a heterodimeric complex consisting of E2F family members ( 1-5 ) and DP proteins ( 1-3 ) .","gene":["E2F family members ( 1-5 )","DP proteins ( 1-3 )","E2F"],"gene_indices_start":[0,45,76],"gene_indices_end":[3,71,95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6747,"text":"We screened a K562 cDNA library and identified novel transcripts , MZF1B and MZF1C .","gene":["MZF1C","MZF1B"],"gene_indices_start":[67,77],"gene_indices_end":[72,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6748,"text":"Ischemic stroke due to protein C deficiency .","gene":["protein C"],"gene_indices_start":[23],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6750,"text":"The kinase is essential in vivo for normal phosphorylation of the CTD and for normal growth and differentiation .","gene":["kinase"],"gene_indices_start":[4],"gene_indices_end":[10],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6751,"text":"The hit1-1 mutation caused a defect in synthesis of a 74-kD heat shock protein .","gene":["hit1-1","74-kD heat shock protein"],"gene_indices_start":[4,54],"gene_indices_end":[10,78],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6752,"text":"A new DNA repair gene from Schizosaccharomyces pombe with homology to RecA was identified and characterized .","gene":["RecA","DNA repair gene from Schizosaccharomyces pombe"],"gene_indices_start":[6,70],"gene_indices_end":[52,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6753,"text":"Recombinant , bacterially expressed PIP5KIalpha possessed PIP5K activity and was immunoreactive with erythroid PIP5KI antibodies .","gene":["PIP5KIalpha","PIP5K","erythroid PIP5KI antibodies"],"gene_indices_start":[36,58,101],"gene_indices_end":[47,63,128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6754,"text":"After transfection , specific TSH beta promoter activity was evident in both TRH-responsive pituitary-derived GH3 and primary pituitary cell cultures .","gene":["TSH beta promoter"],"gene_indices_start":[30],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6755,"text":"The results show that ROS production by viable spermatozoa is highly correlated with the concentration of PMN elastase and the number of both peroxidase-positive and round cells .","gene":["PMN elastase"],"gene_indices_start":[106],"gene_indices_end":[118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6756,"text":"Recombinant unr acts synergistically with recombinant PTB to stimulate translation dependent on the rhinovirus IRES .","gene":["unr","PTB"],"gene_indices_start":[12,54],"gene_indices_end":[15,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6757,"text":"GATA-1 mRNA was present in equivalent levels in both erythroid cell lines , but at a low level in FDC-P1 cells .","gene":["GATA-1 mRNA"],"gene_indices_start":[0],"gene_indices_end":[11],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6758,"text":"DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD .","gene":["CPS domain","Syrian hamster multifunctional protein CAD"],"gene_indices_start":[34,52],"gene_indices_end":[44,94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6760,"text":"Together , these data support a model in which Tax anchors CBP to the HTLV-1 promoter , with strong transcriptional activation resulting from the CBP-associated activities of nucleosome remodeling and recruitment of the general transcription machinery .","gene":["Tax","CBP","HTLV-1 promoter"],"gene_indices_start":[47,59,70],"gene_indices_end":[50,62,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6761,"text":"ORF E8 colinear with ORF E6 , which could generate a 50-amino-acid protein with a hydrophobic segment , did not transform cells when cloned into the pZipNeo vector .","gene":["ORF E6","ORF E8"],"gene_indices_start":[0,21],"gene_indices_end":[6,27],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6762,"text":"Rep-Rep protein interaction was confirmed in vitro through coimmunoprecipitation experiments with a bacterially expressed maltose-binding protein-Rep78 fusion protein in combination with [ 35S ] methionine-labeled Rep78 synthesized in a coupled in vitro transcription-translation system .","gene":["Rep78","maltose-binding protein-Rep78 fusion protein","Rep-Rep protein"],"gene_indices_start":[0,122,214],"gene_indices_end":[15,166,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6763,"text":"The repression domain , and indeed the entire Cdc68 protein , is highly conserved , as shown by the sequence of the Cdc68 functional homolog from the yeast Kluyveromyces lactis and by database searches .","gene":["Cdc68 functional homolog","Cdc68 protein"],"gene_indices_start":[46,116],"gene_indices_end":[59,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6764,"text":"These findings suggest that the adapter Gab1 may redirect c-Met signaling through PI3K away from a c-Akt \/ Pak1 cell survival pathway .","gene":["c-Akt \/ Pak1","c-Met","PI3K","Gab1"],"gene_indices_start":[40,58,82,99],"gene_indices_end":[44,63,86,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6765,"text":"( 2 ) Erythroid 32D Epo1 cells showed a lower level of bulk PKC catalytic activity , lacked the expression of epsilon and eta PKC isoforms , and showed a weak or absent upregulation of the remaining isoforms , except betaI , upon readdition of Epo to growth factor-starved cells .","gene":["Epo1","Epo","eta PKC isoforms","epsilon","betaI","PKC"],"gene_indices_start":[20,60,110,122,217,244],"gene_indices_end":[24,63,117,138,222,247],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6769,"text":"S6K2 is highly homologous to S6K1 in the core kinase and linker regulatory domains but differs from S6K1 in the N- and C-terminal regions and is differently localized primarily to the nucleus because of a C-terminal nuclear localization signal unique to S6K2 .","gene":["S6K1","core kinase","S6K1","S6K2","S6K2"],"gene_indices_start":[0,29,41,100,254],"gene_indices_end":[4,33,52,104,258],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6770,"text":"LMP2A enhances Lyn and Syk ubiquitination in vivo in a fashion that depends on the activity of Nedd4 family members and correlates with destabilization of the Lyn tyrosine kinase .","gene":["Syk","Lyn","LMP2A","Lyn tyrosine kinase","Nedd4"],"gene_indices_start":[0,15,23,95,159],"gene_indices_end":[5,18,26,100,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6771,"text":"Amyloid beta-protein ( Abeta ) is the main constituent of amyloid fibrils found in senile plaques and cerebral vessels in Alzheimer's disease ( AD ) and is derived by proteolysis from the beta-amyloid precursor protein ( APP ) .","gene":["Amyloid beta-protein","Abeta","beta-amyloid precursor protein","APP"],"gene_indices_start":[0,23,188,221],"gene_indices_end":[20,28,218,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6772,"text":"Drug interactions have been found with drugs that compete for the same CYP450 isoenzymes as statins .","gene":["statins","CYP450 isoenzymes"],"gene_indices_start":[71,92],"gene_indices_end":[88,99],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6773,"text":"The Clb5 kinase , which promotes S phase , remains active during the G2-phase arrest of cells of the parental strain , but its activity declines rapidly in sim mutants .","gene":["sim mutants","Clb5 kinase"],"gene_indices_start":[4,156],"gene_indices_end":[15,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6775,"text":"A site-directed R618K mutation in the Stat5 SH2 domain abolished the phosphorylation by Jak2 , while deletion of the C terminus led to Stat5 hyperphosphorylation .","gene":["R618K mutation","Stat5","SH2 domain","Jak2","Stat5"],"gene_indices_start":[16,38,44,88,135],"gene_indices_end":[30,43,54,92,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6776,"text":"Another putative HNF3 site in close apposition to a NF1 \/ CTF site was localized upstream of the silencer-like element .","gene":["silencer-like element","NF1 \/ CTF site","HNF3 site"],"gene_indices_start":[17,52,97],"gene_indices_end":[26,66,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6779,"text":"With respect to the distribution of active MREs over the promoter region , the hMT-IIA gene is largely different from the mouse metallothionein-I gene , suggesting that MRE arrangement is not an important factor for metal regulation .","gene":["metallothionein-I gene","MRE","MREs","hMT-IIA gene"],"gene_indices_start":[43,79,128,169],"gene_indices_end":[47,91,150,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6782,"text":"The hIGF-I gene has two promoters , P1 and P2 .","gene":["hIGF-I gene"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6784,"text":"Five families of Ashkenazi Jewish descent carried the 185delAG mutation and shared the same haplotype at eight polymorphic markers spanning approximately 850 kb at BRCA1 .","gene":["BRCA1"],"gene_indices_start":[164],"gene_indices_end":[169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6788,"text":"The standard dosage of anti-D currently given at all gestational ages is 1 ampoule containing 125 micrograms of anti-D .","gene":["anti-D","anti-D"],"gene_indices_start":[23,112],"gene_indices_end":[29,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6791,"text":"Recovery of carbimazole-induced agranulocytosis following recombinant granulocyte-macrophage colony stimulating factor ( rhGM-CSF ) administration .","gene":["rhGM-CSF","recombinant granulocyte-macrophage colony stimulating factor"],"gene_indices_start":[58,121],"gene_indices_end":[118,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6792,"text":"This locus maps approximately 160 kbp from the genes encoding cytadherence-associated proteins HMW1 and HMW3 , and yet insertions therein result in loss of these proteins and a hemadsorption-negative ( HA- ) phenotype , prompting the designation cytadherence-regulatory locus ( crl ) .","gene":["HMW1","crl","cytadherence-regulatory locus","HMW3"],"gene_indices_start":[95,104,246,278],"gene_indices_end":[99,108,275,281],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6794,"text":"Analysis of intragenic revertants shows that this function depends on the amino acid preceding the first cysteine residue of the DNA-binding domain of Hap1p .","gene":["Hap1p"],"gene_indices_start":[151],"gene_indices_end":[156],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6795,"text":"Here we investigate the role of c-Cbl in development and homeostasis in mice by targeted disruption of the c-Cbl locus . c-Cbl-deficient mice were viable , fertile , and outwardly normal in appearance .","gene":["c-Cbl locus","c-Cbl"],"gene_indices_start":[32,107],"gene_indices_end":[37,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6798,"text":"Detailed molecular organization of the coding and upstream regulatory regions of the murine homeodomain-containing gene , Msx-1 , is reported .","gene":["Msx-1"],"gene_indices_start":[122],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6799,"text":"There is growing evidence that mammalian AMP-activated protein kinase ( AMPK ) plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways .","gene":["mammalian AMP-activated protein kinase","AMPK"],"gene_indices_start":[31,72],"gene_indices_end":[69,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6804,"text":"Because of the probable causal relationship between constitutive p210 ( bcr \/ abl ) protein tyrosine kinase activity and manifestations of chronic-phase chronic myelogenous leukemia ( CML ; myeloid expansion ) , a key goal is to identify relevant p210 substrates in primary chronic-phase CML hematopoietic progenitor cells .","gene":["p210","p210 ( bcr \/ abl )","protein tyrosine kinase"],"gene_indices_start":[65,84,247],"gene_indices_end":[83,107,251],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6805,"text":"The PC2 protein also shows great similarity to the incomplete NH2-terminal sequence of the human furin gene product , a putative membrane-inserted receptor-like molecule .","gene":["PC2 protein","human furin gene product"],"gene_indices_start":[4,91],"gene_indices_end":[15,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6807,"text":"Whether or not there are sequences conferring cAMP responsiveness which are common both to P-450scc and the other steroidogenic P-450 genes remains to be established .","gene":["P-450scc","P-450 genes"],"gene_indices_start":[91,128],"gene_indices_end":[99,139],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6808,"text":"We have also tested Src SH2 mutants for their binding properties and have interpreted our results in light of the recent crystal structure solution for the Src SH2 domain .","gene":["Src SH2 domain","Src SH2 mutants"],"gene_indices_start":[20,156],"gene_indices_end":[35,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6809,"text":"This protein encoded by this cDNA , which we have termed p150TSP ( for TPR-containing , SH2-binding phosphoprotein ) , is located predominantly in the nucleus and is highly conserved in evolution .","gene":["p150TSP","TPR-containing , SH2-binding phosphoprotein"],"gene_indices_start":[57,71],"gene_indices_end":[64,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6810,"text":"We linked hypersensitivity site 2 ( HS2 ) from the locus control region ( LCR ) to a A gamma-globin gene ( A gamma* ) mutationally marked to allow its transcript to be distinguished from endogenous gamma-globin mRNA .","gene":["hypersensitivity site 2","gamma-globin","A gamma-globin","A gamma*","HS2"],"gene_indices_start":[10,36,85,107,198],"gene_indices_end":[33,39,99,115,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6813,"text":"A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly .","gene":["L1"],"gene_indices_start":[21],"gene_indices_end":[23],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6816,"text":"We conclude that the alpha-subunit of the telomere-binding protein , like many transcription factors , has separable DNA-binding and protein-protein interaction domains .","gene":["telomere-binding protein"],"gene_indices_start":[42],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6817,"text":"In the electrophoresis mobility shift assay using nuclear extracts of the myogenic cells , MyoD and myogenin bound to the right E-box in the enhancer region of the MCK gene even in the presence of BMP-2 .","gene":["MyoD","MCK gene","myogenin","BMP-2"],"gene_indices_start":[91,100,164,197],"gene_indices_end":[95,108,172,202],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6821,"text":"Therefore , to understand how ErbB1 \/ ErbB2 signaling contributes to this process , we used the ErbB kinase inhibitor AG1478in ErbB2-dependent BT-474 and SKBR-3 human breast cancer cells .","gene":["ErbB kinase","ErbB1 \/ ErbB2"],"gene_indices_start":[30,96],"gene_indices_end":[43,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6825,"text":"Consistent with this finding , beta-catenin interacted directly with the RA receptor ( RAR ) in a retinoid-dependent manner , but not with the retinoid X receptor ( RXR ) , and RAR competed with TCF for beta-catenin binding .","gene":["RA receptor","TCF","beta-catenin","RAR","beta-catenin","RXR","retinoid X receptor","RAR"],"gene_indices_start":[31,73,87,143,165,177,195,203],"gene_indices_end":[43,84,90,162,168,180,198,215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6826,"text":"Measurement of anti-HCV IgM antibodies with an experimental kit .","gene":["anti-HCV IgM antibodies"],"gene_indices_start":[15],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6828,"text":"In both settings , it can be phosphorylated by cyclin D-dependent kinases , suggesting that its transcriptional activity may normally be regulated through such mechanisms .","gene":["cyclin D-dependent kinases"],"gene_indices_start":[47],"gene_indices_end":[73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6829,"text":"Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation .","gene":["NF-kappaB","Protein phosphatase 2A","protein kinase C zeta","SV40 small t"],"gene_indices_start":[0,50,94,134],"gene_indices_end":[22,71,106,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6830,"text":"The homology to v-mil starts within the coding sequence of exon 1 and ends within the 3' untranslated region of exon 11 , 12 nucleotides downstream from the nonsense codon terminating the large open reading frame shared between c-mil and v-mil .","gene":["c-mil","v-mil","v-mil"],"gene_indices_start":[16,228,238],"gene_indices_end":[21,233,243],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6835,"text":"The mechanism of action is explored in some detail , specifically as it relates to reticuloendothelial system ( RES ) Fc receptor blockade and suppression of antiplatelet antibody synthesis .","gene":["Fc receptor"],"gene_indices_start":[118],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6836,"text":"During this period , administration of additional exogenous PRL did not stimulate further activation ( binding ) of the Stat factors .","gene":["exogenous PRL","Stat factors"],"gene_indices_start":[50,120],"gene_indices_end":[63,132],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6837,"text":"Differential screening of mitochondrial cDNA libraries from male-fertile and cytoplasmic male-sterile sugar-beet reveals genome rearrangements at atp6 and atpA loci .","gene":["atp6","atpA loci"],"gene_indices_start":[146,155],"gene_indices_end":[150,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6838,"text":"ALT levels in responders were lowered by 46% and AST levels were lowered by 35% after 12 weeks of vitamin E treatment .","gene":["AST","ALT"],"gene_indices_start":[0,49],"gene_indices_end":[3,52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6840,"text":"Chaperones \/ HSPs thus play important roles within cell cycle processes .","gene":["Chaperones \/ HSPs"],"gene_indices_start":[0],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6843,"text":"The distal portion of the rat insulin I gene 5'-flanking DNA contains two sequence elements , the Far and FLAT elements , that can function in combination , but not separately , as a beta-cell-specific transcriptional enhancer .","gene":["FLAT elements","Far","rat insulin I gene 5'-flanking DNA"],"gene_indices_start":[26,98,106],"gene_indices_end":[60,101,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6844,"text":"This study describes a new MADS box gene , nmhC5 , which along with nmh7 ( J .","gene":["nmhC5","nmh7","MADS box gene"],"gene_indices_start":[27,43,68],"gene_indices_end":[40,48,72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6845,"text":"To explore the functional significance of these subdomains in PRL binding and signal transduction , deletion mutants of S1 or \/ and S2 subdomains were constructed .","gene":["S2 subdomains","PRL","S1"],"gene_indices_start":[62,120,132],"gene_indices_end":[65,122,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6849,"text":"Our laboratory has recently identified two phosducin-like orphan proteins ( PhLOP1 and PhLOP2 ) that lack the ability to interact with Gbetagamma .","gene":["phosducin-like orphan proteins","Gbetagamma","PhLOP1","PhLOP2"],"gene_indices_start":[43,76,87,135],"gene_indices_end":[73,82,93,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6851,"text":"Surprisingly , double mutants of the shy2-1D mutant with the phytochrome-deficient mutants hy2 , hy3 ( phyB-1 ) and fre1-1 ( phyA-201 ) showed reduced photomorphogenic response in darkness with a longer hypocotyl , a longer inflorescence stem , and a lower level expression of the CAB gene than the shy2-1D single mutant .","gene":["hy3","phyB-1","shy2-1D single mutant","CAB gene","shy2-1D mutant","hy2","fre1-1","phyA-201"],"gene_indices_start":[37,91,97,103,116,125,281,299],"gene_indices_end":[51,94,100,109,122,133,289,320],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6854,"text":"Overexpression of RORgamma has been shown to inhibit T cell receptor-mediated apoptosis in T cell hybridomas and to repress the induction of Fas-ligand and interleukin 2 .","gene":["interleukin 2","Fas-ligand","RORgamma"],"gene_indices_start":[18,141,156],"gene_indices_end":[26,151,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6855,"text":"Circularized Ac \/ Ds transposons : formation , structure and fate .","gene":["Circularized Ac \/ Ds transposons"],"gene_indices_start":[0],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6858,"text":"The study enrolled 994 people co-infected with CMV and HIV , with at least one CD4 count recorded < 100 x 10 ( 6 ) cells \/ l .","gene":["CD4"],"gene_indices_start":[79],"gene_indices_end":[82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6860,"text":"Expression of a dominant-negative ras gene also blocks TIS10 \/ PGS2 induction by v-src .","gene":["TIS10 \/ PGS2","v-src","dominant-negative ras gene"],"gene_indices_start":[16,55,81],"gene_indices_end":[42,67,86],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6861,"text":"High-affinity binding sites for both GR and AP-1 nucleoproteins were identified at adjacent elements within the nGRE .","gene":["GR","nGRE","AP-1 nucleoproteins"],"gene_indices_start":[37,44,112],"gene_indices_end":[39,63,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6863,"text":"The nucleotide sequence of 3874 bp of cloned R . sphaeroides chromosomal DNA , including the three structural genes fbcF , fbcB and fbcC has been determined .","gene":["fbcF","fbcC","fbcB"],"gene_indices_start":[116,123,132],"gene_indices_end":[120,127,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6867,"text":"NH2- and COOH-terminal deletion analysis revealed that both the PH and putative guanine nucleotide exchange factor domains are required , but the zinc butterfly is dispensable , for transformation .","gene":["PH","guanine nucleotide exchange factor domains"],"gene_indices_start":[64,80],"gene_indices_end":[66,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6869,"text":"In this paper we report that ligand binding induced tyrosine phosphorylation in BaF3 cells engineered to express the murine Mpl receptor ( BaF3 \/ mMpl ) .","gene":["murine Mpl receptor","BaF3 \/ mMpl"],"gene_indices_start":[117,139],"gene_indices_end":[136,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6871,"text":"Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter .","gene":["calmodulin-like protein","CLP"],"gene_indices_start":[47,71],"gene_indices_end":[70,74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6872,"text":"Sequence comparison between the translated ORF and a protein database reveal between 26 . 5 and 23 . 4% aa sequence homology to bacterial transmembrane ( TM ) proteins including those mediating chloramphenicol ( Cm ) and tetracycline ( Tc ) resistance and an arabinose-proton symport protein .","gene":["bacterial transmembrane ( TM ) proteins"],"gene_indices_start":[128],"gene_indices_end":[167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6875,"text":"However , the signaling cascade utilized by the urokinase receptor is only incompletely understood .","gene":["urokinase receptor"],"gene_indices_start":[48],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6876,"text":"Substrate specificity of the RNase activity of yeast RNA polymerase III .","gene":["yeast RNA polymerase III","RNase"],"gene_indices_start":[29,47],"gene_indices_end":[34,71],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6877,"text":"Despite its requirement for enhancer-dependent splicing activity in vitro , the dU2AF38 RS domain was also inessential in vivo .","gene":["dU2AF38 RS domain"],"gene_indices_start":[80],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6883,"text":"Fasting gastrin levels ( normal range : 25-110 mU \/ L ) varied from 48 . 78 mU \/ L-168 . 20 ( mean : 85 . 23 mU \/ L ) .","gene":["gastrin"],"gene_indices_start":[8],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6885,"text":"To examine transcriptional regulation of the rat eIF4E gene , 2 . 1 kB of the rat eIF4E promoter region was cloned and the contribution of specific elements in regulating transcription was determined in primary cultures of rat cardiocytes and in a murine C ( 2 ) C ( 12 ) myoblast cell line .","gene":["rat eIF4E promoter region","rat eIF4E gene"],"gene_indices_start":[45,78],"gene_indices_end":[59,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6886,"text":"Cytochrome b in human complex II ( succinate-ubiquinone oxidoreductase ) : cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large ( SDHC ) and small ( SDHD ) subunits to 1q21 and 11q23 .","gene":["SDHC","human complex II","succinate-ubiquinone oxidoreductase","SDHD","Cytochrome b"],"gene_indices_start":[0,16,35,183,202],"gene_indices_end":[12,32,70,187,206],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6887,"text":"Molecular cloning and characterization of a new member of the rat placental prolactin ( PRL ) family , PRL-like protein H .","gene":["rat placental prolactin","PRL","PRL-like protein"],"gene_indices_start":[62,88,103],"gene_indices_end":[85,91,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6888,"text":"During latency , more than 1% of neurons in ganglia that innervate the footpad expressed beta-galactosidase , with the number of positive cells remaining constant for at least 5 months .","gene":["beta-galactosidase"],"gene_indices_start":[89],"gene_indices_end":[107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6889,"text":"Using a novel method combining chromatin immunoprecipitation and genomic array hybridization , we have identified a 460-kb CENP-A-binding DNA domain of a neocentromere derived from the 20p12 region of an invdup ( 20p ) human marker chromosome .","gene":["460-kb CENP-A-binding DNA domain"],"gene_indices_start":[116],"gene_indices_end":[148],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6892,"text":"Ang II significantly induced Ang2 mRNA accumulations without affecting Ang1 or Tie2 expression , which was inhibited by protein kinase C inhibitors and by intracellular Ca ( 2+ ) chelating agents .","gene":["Ang II","protein kinase C","Ang2 mRNA","Ang1","Tie2"],"gene_indices_start":[0,29,71,79,120],"gene_indices_end":[6,38,75,83,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6893,"text":"Antibodies against this purified protein localize RIM1 to mitochondria .","gene":["RIM1"],"gene_indices_start":[50],"gene_indices_end":[54],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6894,"text":"RESULTS : Of the 29 patients who received concurrent chemotherapy and G-CSF , ten ( 34% ; 95% confidence interval [ CI ] , 17 . 9 to 54 . 3% ) were believed to have clinically significant bleomycin toxicity .","gene":["G-CSF"],"gene_indices_start":[70],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6896,"text":"Crystal structure of an oligomer of proteolytic zymogens : detailed conformational analysis of the bovine ternary complex and implications for their activation .","gene":["proteolytic zymogens"],"gene_indices_start":[36],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6898,"text":"Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters .","gene":["dicot rbcS promoters","Maize rbcS promoter"],"gene_indices_start":[0,71],"gene_indices_end":[19,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6899,"text":"COUP transcription factor is a member of the steroid receptor superfamily .","gene":["steroid receptor superfamily","COUP transcription factor"],"gene_indices_start":[0,45],"gene_indices_end":[25,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6901,"text":"Cat proteins are tyrosine-phosphorylated when co-expressed in cells with the focal adhesion kinase Fak and Src .","gene":["Src","Fak","focal adhesion kinase","Cat proteins"],"gene_indices_start":[0,77,99,107],"gene_indices_end":[12,98,102,110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6904,"text":"This transcriptional regulation occurs through modulation of the forkhead transcription factor FKHR-L1 , and IL-3 inhibited FKHR-L1 activity in a PI3K-dependent manner .","gene":["forkhead transcription factor","IL-3","FKHR-L1","FKHR-L1"],"gene_indices_start":[65,95,109,124],"gene_indices_end":[94,102,113,131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6905,"text":"Utero-placental blood flow and the effect of beta 2-adrenoceptor stimulating drugs .","gene":["beta 2-adrenoceptor"],"gene_indices_start":[45],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6910,"text":"Examination of the mitochondrial bc1 complex crystal structure [ Zhang , Z . , Huang , L . , Shulmeister , V .","gene":["mitochondrial bc1 complex crystal structure"],"gene_indices_start":[19],"gene_indices_end":[62],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6912,"text":"The MAP kinase cascade is highly conserved in all eukaryotes and involved in numerous cellular responses .","gene":["MAP kinase cascade"],"gene_indices_start":[4],"gene_indices_end":[22],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6913,"text":"Taken together , these observations indicate that inhibition of p27 ( KIP1 ) transcription through PI3K-induced FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine-mediated survival and proliferation .","gene":["p27","KIP1","PI3K-induced FKHR-L1"],"gene_indices_start":[64,70,99],"gene_indices_end":[67,74,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6914,"text":"The effects of c-myc were further dissected by showing that c-myc can inhibit differentiation independently of Id , a negative regulator of muscle differentiation .","gene":["c-myc","Id","c-myc"],"gene_indices_start":[15,60,111],"gene_indices_end":[20,65,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6922,"text":"Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells .","gene":["rat prostaglandin endoperoxide synthase 2 gene"],"gene_indices_start":[64],"gene_indices_end":[110],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6929,"text":"To test the hypothesis that these elements are required for promoter activity , we compared the reporter expression activity of segments containing mutations of these elements with activity of the parent Hlx promoter sequence .","gene":["parent Hlx promoter sequence"],"gene_indices_start":[197],"gene_indices_end":[225],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6930,"text":"2 : The dynamic moduli of microcrystalline cellulose .","gene":["microcrystalline cellulose"],"gene_indices_start":[26],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6933,"text":"At the genomic level , the sequences of two members of this family are known in the rat Rattus norvegicus : the VCSA1 gene , encoding the prohormone-like polypeptide SMR1 , and the VCSB1 gene , encoding a salivary Pro-rich polypeptide .","gene":["VCSA1 gene","VCSB1 gene","prohormone-like polypeptide SMR1"],"gene_indices_start":[112,138,181],"gene_indices_end":[122,170,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6934,"text":"Angiotensin effect in the human kidney .","gene":["Angiotensin"],"gene_indices_start":[0],"gene_indices_end":[11],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6936,"text":"We have introduced a mutation ( Ser36 -- > Asn ) into this domain of p190 that decreased its ability to bind guanine nucleotide when expressed as a hemagglutinin ( HA ) -tagged protein in COS cells .","gene":["HA","hemagglutinin","p190"],"gene_indices_start":[69,148,164],"gene_indices_end":[73,161,166],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6937,"text":"Increased p53 activity induced by OP is not due to elevated p53 mRNA nor to protein levels .","gene":["p53","p53 mRNA"],"gene_indices_start":[10,60],"gene_indices_end":[13,68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6939,"text":"Tumor necrosis factor ( TNF ) is reported to cause a shock syndrome similar to that produced by endotoxin ( LPS ) .","gene":["LPS","Tumor necrosis factor","endotoxin","TNF"],"gene_indices_start":[0,24,96,108],"gene_indices_end":[21,27,105,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6940,"text":"Phylogenetic analyses of 19 amino acid sequences of 6 related protein types indicate that actin-associated proteins related to gelsolin are monophyletic to a common ancestor and include flightless proteins .","gene":["flightless proteins","gelsolin"],"gene_indices_start":[127,186],"gene_indices_end":[135,205],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6941,"text":"Whereas the mutant enzymes terminate normally at the late terminator in T7 DNA ( T ( phi ) ) and rrnB T2 , they fail to terminate at one of the termination sites of rrnB T1 , and also fail to recognize the PTH and CJ signals .","gene":["PTH"],"gene_indices_start":[206],"gene_indices_end":[209],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6943,"text":"Alternative splicing of ClC-6 ( a member of the CIC chloride-channel family ) transcripts generates three truncated isoforms one of which , ClC-6c , is kidney-specific .","gene":["CIC chloride-channel family","ClC-6c","ClC-6"],"gene_indices_start":[24,48,140],"gene_indices_end":[29,75,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6945,"text":"We purified both proteins from human platelet membranes using DEAE-Sepharose chromatography followed by mAb F11 affinity chromatography .","gene":["mAb F11"],"gene_indices_start":[104],"gene_indices_end":[111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6948,"text":"A recombinant with a 5' end from src and a 3' end from ros , called SRC x ROS , transformed chicken embryo fibroblasts ( CEF ) to a spindle shape morphology , mimicking that of UR2 .","gene":["src","SRC","UR2","ros","ROS"],"gene_indices_start":[33,55,68,74,177],"gene_indices_end":[36,58,71,77,180],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6950,"text":"S6 kinase activation requires displacement of this inhibitory segment , which is proposed to occur consequent to its multiple phosphorylation .","gene":["S6 kinase"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6951,"text":"Thus , the PCE binds a Pbx dimer partner that behaves unlike Class I Hox proteins .","gene":["Class I Hox proteins","PCE","Pbx dimer partner"],"gene_indices_start":[11,23,61],"gene_indices_end":[14,40,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6953,"text":"Purified P7 could be assembled onto particles lacking P7 and particles lacking both P2 ( RNA polymerase ) and P7 .","gene":["RNA polymerase","P2","Purified P7","P7"],"gene_indices_start":[0,54,84,89],"gene_indices_end":[11,56,86,103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6954,"text":"Deletion analyses of the pCD41 ORF-A and the use of promoter constructs further mapped an internal functional promoter within the pCD41 sequence that can direct the synthesis of the trans-activating protein .","gene":["pCD41 sequence","pCD41 ORF-A"],"gene_indices_start":[25,130],"gene_indices_end":[36,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6956,"text":"Our data suggest that trans-activation from the prothymosin intron enhancer is a faithful reflection of the transforming properties of the Myc protein .","gene":["prothymosin intron enhancer","Myc protein"],"gene_indices_start":[48,139],"gene_indices_end":[75,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6957,"text":"The mRNA expression of RFX1 , RFX2 , and RFX3 was detected ubiquitously , but in transient-transfection assays , multimerized RFX binding sites in front of a basal promoter efficiently functioned in a tissue- and lineage-specific manner .","gene":["RFX1","multimerized RFX binding sites","RFX2","RFX3"],"gene_indices_start":[23,30,41,113],"gene_indices_end":[27,34,45,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6958,"text":"To study the role of heavy chain motifs in substrate recognition , secreted variants of recombinant bovine proenteropeptidase were constructed by replacing the transmembrane domain with a signal peptide .","gene":["recombinant bovine proenteropeptidase","heavy chain motifs"],"gene_indices_start":[21,88],"gene_indices_end":[39,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6960,"text":"The p53-homolog p73beta also activated the PIG3 promoter , but in contrast to p53 , the proline-rich domain of p73beta ( residues 81-113 ) was dispensable to induce the PIG3 promoter .","gene":["p73beta","PIG3 promoter","p53-homolog","p53","PIG3 promoter","p73beta ( residues 81-113 )"],"gene_indices_start":[4,16,43,78,111,169],"gene_indices_end":[15,23,56,81,138,182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6961,"text":"The predicted amino acid sequence of m-Staf is highly homologous to that of Staf , another selenocysteine tRNA gene transcription activating factor of Xenopus laevis .","gene":["selenocysteine tRNA gene transcription activating factor","m-Staf","Staf"],"gene_indices_start":[37,76,91],"gene_indices_end":[43,80,147],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6962,"text":"The DRF-2 nuclear protein has characteristics similar to those of the muscle-specific regulatory factor , MEF-2 ( Buskin and Hauschka 1989 ; Gossett et al . , 1989 ) .","gene":["MEF-2","DRF-2 nuclear protein"],"gene_indices_start":[4,106],"gene_indices_end":[25,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6965,"text":"TNFalpha and IL-6 levels were determined in the culture supernatants .","gene":["IL-6","TNFalpha"],"gene_indices_start":[0,13],"gene_indices_end":[8,17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6966,"text":"The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity .","gene":["adenovirus type 5 E1A","ATF","human papillomavirus type 16 E7 protein","Oct-1"],"gene_indices_start":[4,56,166,174],"gene_indices_end":[43,77,169,179],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6967,"text":"In two further cases ( one type I and one type III SMA ) , de novo deletions of only one copy of Ag1-CA and C212 were found .","gene":["C212","Ag1-CA"],"gene_indices_start":[97,108],"gene_indices_end":[103,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6968,"text":"In supine position , plasma ANP levels ranged from 12 pg \/ ml to 51 . 5 pg \/ ml , with an average level of 35 . 3 + \/ - 11 . 5 pg \/ ml .","gene":["ANP"],"gene_indices_start":[28],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6970,"text":"The 5' external transcribed spacer ( ETS ) region of the pre-rRNA in Saccharomyces cerevisiae contains a sequence with 10 bp of perfect complementarity to the U3 snoRNA .","gene":["U3 snoRNA"],"gene_indices_start":[159],"gene_indices_end":[168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6971,"text":"This constitutes evidence for an in vivo role of SRC-1 in dimerization-induced activation by OR1 \/ RXRalpha .","gene":["OR1 \/ RXRalpha","SRC-1"],"gene_indices_start":[49,93],"gene_indices_end":[54,107],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6974,"text":"The sera and nasal secretions of 142 patients , who were positive in HD or mites skin test , were subjected to a radioallergosorbent test ( RAST ) for estimating the specific IgE antibody activity to mites .","gene":["IgE antibody"],"gene_indices_start":[175],"gene_indices_end":[187],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6975,"text":"This organization suggests that duplication events that have generated the primate FUT3-FUT5-FUT6 cluster might have occurred through a long-interspersed-nuclear-element-based mechanism of unequal crossing over , as described for the globin cluster .","gene":["globin cluster","primate FUT3-FUT5-FUT6 cluster"],"gene_indices_start":[75,234],"gene_indices_end":[105,248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6977,"text":"BACKGROUND : In the ubiquitin-dependent proteolysis pathway , a ubiquitin ligase ( E3 ) is responsible for substrate selectivity and timing of degradation .","gene":["ubiquitin ligase","E3"],"gene_indices_start":[64,83],"gene_indices_end":[80,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6988,"text":"Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J ( SPE-I and SPE-J ) from Streptococcus pyogenes .","gene":["streptococcal pyrogenic exotoxins I and J","SPE-J","SPE-I"],"gene_indices_start":[50,94,104],"gene_indices_end":[91,99,109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6989,"text":"Patients with an enzymatic activity below X--1 manifested a decrease of the content of IgA , IgG , IgM , T and B lymphocytes , and of phagocytic activity of neutrophils as compared to patients exhibiting a high enzymatic activity .","gene":["IgM","IgG","IgA"],"gene_indices_start":[87,93,99],"gene_indices_end":[90,96,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6990,"text":"These data suggest that the combined treatment with a thromboxane synthetase inhibitor and a thromboxane receptor antagonist provides a better protection against digoxin intoxication than with either agent alone .","gene":["thromboxane synthetase","thromboxane receptor"],"gene_indices_start":[54,93],"gene_indices_end":[76,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6992,"text":"These are the long terminal repeat ( LTR ) promoter , which regulates expression of the viral structural proteins , and a second internal promoter , located towards the 3' end of the env gene , that directs expression of the viral auxiliary proteins .","gene":["env gene","long terminal repeat ( LTR ) promoter"],"gene_indices_start":[14,183],"gene_indices_end":[51,191],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6995,"text":"A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP .","gene":["human tissue-type plasminogen activator gene promoter","exon-located activator protein-2 binding site","cAMP-responsive element"],"gene_indices_start":[27,58,111],"gene_indices_end":[50,103,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":6999,"text":"Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor ( TR ) is TR isoform-specific .","gene":["TR","thyroid hormone receptor","TR"],"gene_indices_start":[88,115,123],"gene_indices_end":[112,117,125],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7000,"text":"cDNA encoding a functional feline liver \/ bone \/ kidney-type alkaline phosphatase .","gene":["feline liver \/ bone \/ kidney-type alkaline phosphatase"],"gene_indices_start":[27],"gene_indices_end":[81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7002,"text":"RNase protection assays revealed a correlation between the levels of dorsal and ventral skin expression with pigmentation \/ phaeomelanin phenotypes .","gene":["RNase"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7003,"text":"Because chromosome X is frequently involved in structural alterations in neoplastic Syrian hamster cells transformed by chemical carcinogens and oncogenic viruses , the localization of the cph locus on this chromosome supports the notion that the cph oncogene plays a role in the malignant conversion of chemically transformed hamster fibroblasts .","gene":["cph locus","cph oncogene"],"gene_indices_start":[189,247],"gene_indices_end":[198,259],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7006,"text":"A G22V mutant of M-Ras was constitutively active and its expression in an interleukin-3 ( IL-3 ) -dependent mast cell \/ megakaryocyte cell line resulted in increased survival in the absence of IL-3 , increased growth in IL-4 , and , at high expression levels , in factor-independent growth .","gene":["IL-3","IL-3","G22V mutant","interleukin-3","M-Ras","IL-4"],"gene_indices_start":[2,17,74,90,193,220],"gene_indices_end":[13,22,87,94,197,224],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7008,"text":"However , the N63S mutation in the wild-type VP5 background increased the interaction , as judged by the beta-galactosidase activity , by a factor of 9 relative to when the PR7 mutation was present .","gene":["beta-galactosidase","wild-type VP5"],"gene_indices_start":[35,105],"gene_indices_end":[48,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7010,"text":"The binding of PH domains to Gbetagamma was inhibited by preincubation of Gbetagamma with the GDP-bound but not the GTP-bound form of Gialpha .","gene":["Gbetagamma","Gialpha","Gbetagamma","PH domains"],"gene_indices_start":[15,29,74,134],"gene_indices_end":[25,39,84,141],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7012,"text":"False positive amniotic fluid alpha fetoprotein levels resulting from contamination with fetal blood : results of an experiment .","gene":["amniotic fluid alpha fetoprotein"],"gene_indices_start":[15],"gene_indices_end":[47],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7014,"text":"Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli .","gene":["RNase T","single-strand DNA exonuclease"],"gene_indices_start":[18,90],"gene_indices_end":[25,119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7015,"text":"All patients had elevated levels of serum IgE antibodies to the crude soybean extract ; binding values ranged from 2 . 3 to 28 . 1 times that of a negative control serum .","gene":["serum IgE antibodies"],"gene_indices_start":[36],"gene_indices_end":[56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7016,"text":"The gene includes three exons and two introns within 1 . 6 kilobases of DNA , and the entire open reading frame for glycoprotein IX is included within the third exon .","gene":["glycoprotein IX"],"gene_indices_start":[116],"gene_indices_end":[131],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7017,"text":"DNA polymerase E , DNA ligase III and a DNA structure-specific endonuclease co-purify with the five polypeptide complex .","gene":["DNA structure-specific endonuclease","DNA polymerase E","DNA ligase III"],"gene_indices_start":[0,19,40],"gene_indices_end":[16,33,75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7018,"text":"Yeast U1 snRNP therefore contains 16 different proteins , including seven snRNP core proteins , three homologues of the metazoan U1 snRNP-specific proteins , and six yeast-specific U1 snRNP proteins .","gene":["snRNP core proteins","Yeast U1 snRNP","metazoan U1 snRNP-specific proteins","yeast-specific U1 snRNP proteins"],"gene_indices_start":[0,74,120,166],"gene_indices_end":[14,93,155,198],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7022,"text":"The frameshift initiated by ADEx2 is believed to alter the regular coding sequence , acting as a loss-of-function ASIP mutation .","gene":["ASIP mutation"],"gene_indices_start":[114],"gene_indices_end":[127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7024,"text":"METHODS : Out of 171 patients receiving anticoagulation between July 1992 and December 1993 , 83 patients with hemispheric embolisms received heparin within 72 hours from onset ( activated partial thromboplastin time [ aPTT ] 1 . 5 times control value ) .","gene":["thromboplastin"],"gene_indices_start":[197],"gene_indices_end":[211],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7026,"text":"Open reading frames in a 4556 nucleotide sequence within MDV-1 BamHI-D DNA fragment : evidence for splicing of mRNA from a new viral glycoprotein gene .","gene":["MDV-1 BamHI-D DNA fragment"],"gene_indices_start":[57],"gene_indices_end":[83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7030,"text":"The size discrepancy is not due to glycosylation or phosphorylation of Ag35 but may result from a proline-rich sequence which occurs in this polypeptide .","gene":["Ag35"],"gene_indices_start":[71],"gene_indices_end":[75],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7033,"text":"The co-existence of TE domains within modular PKSs along with physically separated , monofunctional TEs ( TE IIs ) has been reported for a number of modular polyketide and non-ribosomal peptide synthases ( NRPS ) .","gene":["non-ribosomal peptide synthases","TE domains","TE IIs","TEs","PKSs","NRPS"],"gene_indices_start":[20,46,100,106,172,206],"gene_indices_end":[30,50,103,112,203,210],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7035,"text":"SNAP-23 plays an important role in the regulation of vesicle trafficking in mammalian cells .","gene":["SNAP-23"],"gene_indices_start":[0],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7036,"text":"Recombinant plasmid pFV100 was subsequently isolated by its ability to complement B-band expression in ge6 .","gene":["ge6"],"gene_indices_start":[103],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7037,"text":"Surprisingly , there is no sequence homology between this region of Ly-6E and the established consensus for the interferon-stimulated response element , which has been shown functionally important to all previously characterized alpha \/ beta interferon-inducible promoters .","gene":["interferon-stimulated response element","Ly-6E","alpha \/ beta interferon-inducible promoters"],"gene_indices_start":[68,112,229],"gene_indices_end":[73,150,272],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7038,"text":"Ectopic expression of the dominant mutant Lg3 allele is believed to cause the phenotype .","gene":["dominant mutant Lg3 allele"],"gene_indices_start":[26],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7039,"text":"Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters .","gene":["furin"],"gene_indices_start":[55],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7041,"text":"A motif ( TGATGTCA ) which matches a CREB site and is similar to an AP-1 site is embedded within ER2 .","gene":["TGATGTCA","ER2","AP-1 site","CREB site"],"gene_indices_start":[10,37,68,97],"gene_indices_end":[18,46,77,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7048,"text":"The optimal sequence for interaction with mu 2 and with AP-2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3 .","gene":["mu 2","AP-2"],"gene_indices_start":[42,56],"gene_indices_end":[46,60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7049,"text":"Unlike most other small G proteins which are expressed ubiquitously , TTF was transcribed only in hemopoietic cells as a 2 . 2 kb transcript .","gene":["small G proteins","TTF"],"gene_indices_start":[18,70],"gene_indices_end":[34,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7051,"text":"Nhp2p is a highly basic protein that belongs to a family of putative RNA-binding proteins .","gene":["RNA-binding proteins","Nhp2p"],"gene_indices_start":[0,69],"gene_indices_end":[5,89],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7053,"text":"Of 165 women with non-malignant diagnoses 26 ( 16% ) had CA 125 levels in excess of 35 U \/ ml and 8 ( 5% ) greater than 65 U \/ ml .","gene":["CA 125"],"gene_indices_start":[57],"gene_indices_end":[63],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7054,"text":"P-CIP1 , a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase , is associated with endosomes .","gene":["peptidylglycine alpha-amidating monooxygenase","P-CIP1"],"gene_indices_start":[0,69],"gene_indices_end":[6,114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7056,"text":"However , a 10--15% lengthening of the partial thromboplastin time is evident after 24 hours of storage .","gene":["thromboplastin"],"gene_indices_start":[47],"gene_indices_end":[61],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7057,"text":"In the present study we have investigated the regulatory mechanism for CD95L expression .","gene":["CD95L"],"gene_indices_start":[71],"gene_indices_end":[76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7062,"text":"Full-length FLAP clones were isolated from a mouse skeletal muscle cDNA library .","gene":["Full-length FLAP"],"gene_indices_start":[0],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7064,"text":"Regulation of the Raf kinase in T cells differs from findings with a variety of cell lines that the catalytic domain of Raf ( Raf ( delta26-303 ) ) shows no activity .","gene":["Raf ( delta26-303","catalytic domain of Raf","Raf kinase"],"gene_indices_start":[18,100,126],"gene_indices_end":[28,123,143],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7071,"text":"The deduced amino acid sequence of the mouse HO-1 gene is identical to that of p32 , initially identified as a stress-induced protein in mouse BALBc \/ 3T3 cells .","gene":["mouse HO-1 gene","p32"],"gene_indices_start":[39,79],"gene_indices_end":[54,82],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7073,"text":"These results suggest that both transcription activators depend on or interact with different subunits of RNA polymerase , although their role in formation of proper DNA geometry may also be crucial .","gene":["RNA polymerase"],"gene_indices_start":[106],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7075,"text":"Molecular cloning of a cDNA encoding rat NADH-cytochrome b5 reductase and the corresponding gene .","gene":["rat NADH-cytochrome b5 reductase"],"gene_indices_start":[37],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7077,"text":"We also localized the Fra-2 phosphorylation sites by MAPK to three threonine and three serine residues in the COOH-terminal region by means of site-directed mutagenesis and showed that the threonine residues were more susceptible to MAPK .","gene":["Fra-2 phosphorylation sites","MAPK","MAPK"],"gene_indices_start":[22,53,233],"gene_indices_end":[49,57,237],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7079,"text":"The QT interval was related to various components of the insulin resistance syndrome , including BP and insulin sensitivity .","gene":["insulin","insulin"],"gene_indices_start":[57,104],"gene_indices_end":[64,111],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7082,"text":"Ongoing and future investigations may better define the optimal approach for local control , the optimal duration of maintenance chemotherapy , and the possible role of biologic response modifiers and growth factors in further improving the outcome for patients with this disease .","gene":["growth factors"],"gene_indices_start":[201],"gene_indices_end":[215],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7083,"text":"Effects of long-term parenteral nutrition on gastrin release in dogs .","gene":["gastrin"],"gene_indices_start":[45],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7084,"text":"The predicted amino acid sequence of the SGC1 gene product includes a region with substantial similarity to the basic-helix-loop-helix domain of the Myc family of DNA-binding proteins .","gene":["SGC1 gene product","Myc family"],"gene_indices_start":[41,149],"gene_indices_end":[58,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7086,"text":"To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles , we compared untreated young males IGD ( n = 7 ) and DP ( n = 7 ) to normal pubertal male controls ( n = 6 ) .","gene":["GnRH"],"gene_indices_start":[38],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7087,"text":"Monitoring patients with acute leukemia for IL-1 and TNF levels throughout the clinical course of disease may help clarify the causes of febrile episodes .","gene":["TNF","IL-1"],"gene_indices_start":[44,53],"gene_indices_end":[48,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7089,"text":"The P131 ORF is followed in-frame by a second ORF which is probably expressed by partial readthrough of the UGA termination codon of the P131 ORF to produce a polypeptide of M ( r ) 191044 ( P191 ) .","gene":["P131 ORF","P131 ORF","P191"],"gene_indices_start":[4,137,191],"gene_indices_end":[12,145,195],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7090,"text":"The CANNTG motifs were found to bind MyoD and myogenin fusion proteins and to interact with proteins in nuclear extracts from cultured myotubes .","gene":["myogenin fusion proteins","CANNTG motifs","MyoD"],"gene_indices_start":[4,37,46],"gene_indices_end":[17,41,70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7092,"text":"D3S1261 is physically located at or near the MITF locus , while D3S2465 and D3S1766 are flanking the locus at about 17 . 5 cM genetic distance each side .","gene":["D3S1766","D3S2465","MITF locus","D3S1261"],"gene_indices_start":[0,45,64,76],"gene_indices_end":[7,55,71,83],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7093,"text":"CyIIa transcription follows , and is therefore downstream of , the initial specification of these embryonic domains .","gene":["CyIIa"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7095,"text":"As no complete PPARgamma antagonists have been described hitherto , we have constructed a dominant-negative mutant receptor to inhibit wild-type PPARgamma action .","gene":["PPARgamma","PPARgamma"],"gene_indices_start":[15,145],"gene_indices_end":[24,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7097,"text":"PCNA mRNA has a 3'UTR antisense to yellow crescent RNA and is localized in ascidian eggs and embryos .","gene":["PCNA mRNA"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7098,"text":"Anti-PTB antibodies did not inhibit the binding of PTB to RNA because they were able to supershift RNA-PTB complexes .","gene":["PTB","RNA-PTB complexes","Anti-PTB antibodies"],"gene_indices_start":[0,51,99],"gene_indices_end":[19,54,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7101,"text":"The measurement of the areas of fibrin , of tissue and fibrinolysis , at the above mentioned times , has been effected at standard magnification ( 15 X ) by an image analyser ( Videoplan ) scale 1 : 8 .","gene":["fibrin"],"gene_indices_start":[32],"gene_indices_end":[38],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7103,"text":"Staining with IF MoAB alone of BAL fluid only seemed to be even more sensitive than silver methenamine staining of BAL , TBB and brushing material .","gene":["IF"],"gene_indices_start":[14],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7104,"text":"Evidence for the involvement of the Glc7-Reg1 phosphatase and the Snf1-Snf4 kinase in the regulation of INO1 transcription in Saccharomyces cerevisiae .","gene":["INO1","Snf1-Snf4 kinase","Glc7-Reg1 phosphatase"],"gene_indices_start":[36,66,104],"gene_indices_end":[57,82,108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7106,"text":"Effects of intramammary endotoxin infusion on milking-induced oxytocin release .","gene":["oxytocin"],"gene_indices_start":[62],"gene_indices_end":[70],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7109,"text":"The MSL complex is specifically localized on the male X chromosome to increase its expression approximately 2-fold .","gene":["MSL complex"],"gene_indices_start":[4],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7112,"text":"Taken together , our results demonstrate that CAP1 is involved in multidrug resistance and oxidative stress response in C . albicans .","gene":["CAP1"],"gene_indices_start":[46],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7113,"text":"Sequence analysis and identification of two hyp regulatory mutants .","gene":["hyp regulatory mutants"],"gene_indices_start":[44],"gene_indices_end":[66],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7117,"text":"Recently , cell-surface TRAIL has been shown to be expressed by activated human and mouse T lymphocytes , raising the possibility that TRAIL might be involved in T cell-mediated cytotoxicity and \/ or immune regulation .","gene":["TRAIL","TRAIL"],"gene_indices_start":[24,135],"gene_indices_end":[29,140],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7118,"text":"Classical ligand-activated nuclear receptors ( e . g . thyroid hormone receptor , retinoic acid receptor ) , orphan nuclear receptors ( e . g .","gene":["thyroid hormone receptor","ligand-activated nuclear receptors","retinoic acid receptor","orphan nuclear receptors"],"gene_indices_start":[10,55,82,109],"gene_indices_end":[44,79,104,133],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7121,"text":"Activities of hepatic cytochrome P-450-dependent metabolizing enzymes such as aminopyrine- and TMO N-demethylase and aniline hydroxylase activity were decreased by pretreatment of rats with cimetidine , whereas in the rats pretreated with ranitidine , these enzyme activities were not changed .","gene":["aniline hydroxylase","aminopyrine- and TMO N-demethylase"],"gene_indices_start":[78,117],"gene_indices_end":[112,136],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7124,"text":"Management of postvitrectomy diabetic vitreous hemorrhage with tissue plasminogen activator ( t-PA ) and volume homeostatic fluid-fluid exchanger .","gene":["tissue plasminogen activator","t-PA"],"gene_indices_start":[63,94],"gene_indices_end":[91,98],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7125,"text":"After peripheral administration of both CRF and TRH , ACTH levels were significantly higher on the tumor side in all patients .","gene":["CRF","TRH","ACTH"],"gene_indices_start":[40,48,54],"gene_indices_end":[43,51,58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7131,"text":"This c-Jun activity is inhibited by c-Fos , another protooncoprotein that can dimerize with c-Jun to form the transcription factor AP-1 .","gene":["AP-1","c-Jun","c-Jun","c-Fos"],"gene_indices_start":[5,36,92,131],"gene_indices_end":[10,41,97,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7133,"text":"The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins .","gene":["NF1 locus","yeast IRA proteins","mammalian GAP"],"gene_indices_start":[4,56,74],"gene_indices_end":[13,69,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7135,"text":"Subsequent to their secretion , the IGF-II in xz97 and G11 cells accumulated in the conditioned medium mostly as two partially processed species with appMr , of 17K and 14K , respectively .","gene":["IGF-II"],"gene_indices_start":[36],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7138,"text":"Experimental data showed that these abnormal proteins are constitutively localized in the nucleus , have lost the transcriptional repressor functions typical of normal NF-kappa B2p52 and may be capable of transactivation activity .","gene":["NF-kappa B2p52"],"gene_indices_start":[168],"gene_indices_end":[182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7140,"text":"By using lacZ fusions , it was possible to localize the DNA sequences required to mediate nitrate repression to the pfl promoter-regulatory region .","gene":["pfl promoter-regulatory region","lacZ fusions"],"gene_indices_start":[9,116],"gene_indices_end":[21,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7142,"text":"Splicing of the K-SAM alternative exon of the fibroblast growth factor receptor 2 gene is heavily dependent on the U-rich sequence IAS1 lying immediately downstream from its 5' splice site .","gene":["K-SAM","IAS1","fibroblast growth factor receptor 2 gene"],"gene_indices_start":[16,46,131],"gene_indices_end":[21,86,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7143,"text":"Biochemical examinations of calcium-phosphorus metabolism included ions and PTH concentrations in blood serum , and the activity of bone isoenzyme of AP .","gene":["PTH","AP"],"gene_indices_start":[76,150],"gene_indices_end":[79,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7146,"text":"Altogether , these data suggest that Ypt51p , Ypt52p , and Ypt53p are required for transport in the endocytic pathway and for correct sorting of vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway .","gene":["vacuolar hydrolases","Ypt52p","Ypt53p","Ypt51p"],"gene_indices_start":[37,46,59,145],"gene_indices_end":[43,52,65,164],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7148,"text":"Restriction mapping analysis localized this cDNA to the HHV-6A ( U1102 ) genomic BamHI G fragment , at the right end of the unique long segment of the genome and to the SalI L and SalI O fragments within the left and right terminal direct repeat regions , respectively .","gene":["SalI O fragments","SalI L","HHV-6A ( U1102 ) genomic BamHI G fragment"],"gene_indices_start":[56,169,180],"gene_indices_end":[97,175,196],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7149,"text":"Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP , PC-1 , and an orphan human homolog of a secreted nematode protein .","gene":["cellular alpha-SNAP","PC-1"],"gene_indices_start":[47,69],"gene_indices_end":[66,73],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7156,"text":"One of these factors , IRF-2 , was initially cloned as an antagonistic counterpart to IRF-1 with oncogenic potential .","gene":["IRF-1","IRF-2"],"gene_indices_start":[23,86],"gene_indices_end":[28,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7159,"text":"The coding sequences of the Crry gene encompass over 25 kb of DNA , whereas the Crry-ps sequences are included within a single 5 . 6-kb Eco-R1 fragment .","gene":["Crry gene","5 . 6-kb Eco-R1 fragment","Crry-ps sequences"],"gene_indices_start":[28,80,127],"gene_indices_end":[37,97,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7161,"text":"Prevention of acute paraquat toxicity in rats by superoxide dismutase .","gene":["superoxide dismutase"],"gene_indices_start":[49],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7163,"text":"Thus , hGRbeta potentially functions as a dominant negative inhibitor of hGRalpha activity .","gene":["hGRalpha","hGRbeta"],"gene_indices_start":[7,73],"gene_indices_end":[14,81],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7167,"text":"There are two immunogenic sites on the type A influenza A \/ Japan \/ 57 ( H2N2 ) hemagglutinin ( HA ) that can be recognized by class I major histocompatibility complex ( MHC ) , H-2Kd-restricted cytolytic T lymphocytes ( CTLs ) .","gene":["MHC","type A influenza A \/ Japan \/ 57 ( H2N2 ) hemagglutinin","HA","class I major histocompatibility complex"],"gene_indices_start":[39,96,127,170],"gene_indices_end":[93,98,167,173],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7170,"text":"Entry of yeast cells into the mitotic cell cycle ( Start ) involves a form of the CDC28 kinase that associates with G1-specific cyclins encoded by CLN1 and CLN2 ( ref .","gene":["CDC28 kinase","CLN2","cyclins","CLN1"],"gene_indices_start":[82,128,147,156],"gene_indices_end":[94,135,151,160],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7172,"text":"In this study , we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins .","gene":["STAT"],"gene_indices_start":[32],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7174,"text":"Thus , elongin C is found to oligomerize in solution and to undergo significant structural rearrangements upon binding of two different partner proteins .","gene":["elongin C"],"gene_indices_start":[7],"gene_indices_end":[16],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7176,"text":"Using sequence information from human BMAL1 ( hBMAL1 ) cDNAs previously reported by our laboratory , we have isolated and characterized cDNAs encoding three splice variants of the mouse BMAL1 ( mBMAL1 ) gene .","gene":["human BMAL1","mouse BMAL1","hBMAL1","mBMAL1"],"gene_indices_start":[32,46,180,194],"gene_indices_end":[43,52,191,200],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7177,"text":"In support of a role at the spindle , two-hybrid library screening with HEF1 identifies the human homolog of the G2 \/ M spindle-regulatory protein Dim1p as a specific interactor with a region of HEF1 encompassed in p55 ( HEF1 ) .","gene":["p55 ( HEF1 )","G2 \/ M spindle-regulatory protein Dim1p","HEF1","HEF1"],"gene_indices_start":[72,113,195,215],"gene_indices_end":[76,152,199,227],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7178,"text":"An endogenous mammalian regulator of this process , named Usurpin , has been identified ( aliases for Usurpin include CASH , Casper , CLARP , FLAME-1 , FLIP , I-FLICE and MRIT ) .","gene":["FLAME-1","MRIT","Usurpin","Casper","Usurpin","CLARP","CASH","I-FLICE","FLIP"],"gene_indices_start":[58,102,118,125,134,142,152,159,171],"gene_indices_end":[65,109,122,131,139,149,156,166,175],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7180,"text":"Although MAP ( mitogen-activated protein ) kinases are implicated in cell proliferation and differentiation in many cell types , the role of MAP kinases in cardiac hypertrophy remains unclear .","gene":["MAP kinases","MAP ( mitogen-activated protein ) kinases"],"gene_indices_start":[9,141],"gene_indices_end":[50,152],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7181,"text":"AGO1 is similar to QDE-2 required for quelling and RDE-1 required for RNAi .","gene":["QDE-2","AGO1","RDE-1"],"gene_indices_start":[0,19,51],"gene_indices_end":[4,24,56],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7182,"text":"METHODS : Fifty-eight patients who underwent a curative hepatic resection for HCC and whose preoperative AFP levels were > 100 ng \/ ml , were selected for this study .","gene":["AFP"],"gene_indices_start":[105],"gene_indices_end":[108],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7183,"text":"Significant alterations in the vasectomized rats from sham rats included : testicular and epididymal hypertrophy , formation of pathologic vas deferens granulomas , decreased total serum protein , lowered alpha-globulin levels as shown by serum electrophoresis , and increased sperm agglutinin antibody titers .","gene":["alpha-globulin"],"gene_indices_start":[205],"gene_indices_end":[219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7186,"text":"Comparative mapping of the Brassica S locus region and its homeolog in Arabidopsis .","gene":["Brassica S locus region"],"gene_indices_start":[27],"gene_indices_end":[50],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7187,"text":"In addition , we show that the expression of individual members of one subfamily of KRAB zinc finger genes is restricted to specific hematopoietic cell lineages .","gene":["KRAB zinc finger genes"],"gene_indices_start":[84],"gene_indices_end":[106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7188,"text":"Two of the ORFs are completely internal to longer ones and a third is partially embedded in G2850 .","gene":["G2850"],"gene_indices_start":[92],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7191,"text":"Nevertheless , antibodies directed against an epitope-tagged version of Prp42p specifically precipitate U1 snRNA from yeast extracts .","gene":["Prp42p","U1 snRNA"],"gene_indices_start":[72,104],"gene_indices_end":[78,112],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7192,"text":"They lack a predicted single stranded ( ss ) DNA binding motif that is unique the large terminase proteins in T4 gp17 , and that has been implicated in recognizing ssDNA regions in replicating and recombining T4DNA destined to be packaged .","gene":["terminase proteins","T4 gp17"],"gene_indices_start":[88,110],"gene_indices_end":[106,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7194,"text":"The ORF3 mutant produced reduced levels of tabtoxin , indicating that ORF3 may have a role in T beta L biosynthesis .","gene":["T beta L","tabtoxin"],"gene_indices_start":[43,94],"gene_indices_end":[51,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7195,"text":"No significant differences existed between the two age groups in baseline characteristics , including treatment protocol , performance status , and serum lactate dehydrogenase ( LDH ) level .","gene":["serum lactate dehydrogenase","LDH"],"gene_indices_start":[148,178],"gene_indices_end":[175,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7196,"text":"Interferon stimulated gene factor 3 ( ISGF3 ) is a trimeric transcription factor activated on treatment of cells with interferon-alpha and beta ( type I IFNs ) .","gene":["interferon-alpha and beta","type I IFNs","ISGF3","Interferon stimulated gene factor 3"],"gene_indices_start":[0,38,118,146],"gene_indices_end":[35,43,143,157],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7198,"text":"Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor .","gene":["epidermal growth factor receptor","c-fos gene"],"gene_indices_start":[14,58],"gene_indices_end":[24,90],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7199,"text":"Fifty six young patients ( age < 45 yr ) with doppler-proven DVT were investigated for the presence of resistance to activated protein C ( APC-R ) , lupus anticoagulant ( LA ) , anticardiolipin antibodies and deficiencies of protein C , protein S , ATIII activities .","gene":["anticardiolipin antibodies","ATIII","protein C","activated protein C","protein S","APC-R"],"gene_indices_start":[117,139,178,225,237,249],"gene_indices_end":[136,144,204,234,246,254],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7202,"text":"However , in those studies due to the presence of thiol agents in the PKC preparations , the sensitive reaction of BPO with redox-active cysteine residues in PKC was not observed .","gene":["PKC","PKC"],"gene_indices_start":[70,158],"gene_indices_end":[73,161],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7204,"text":"Recently , extremely high levels of endothelin-1 ( ET-1 ) were detected in the pericardial fluid of patients undergoing cardiac surgery .","gene":["endothelin-1","ET-1"],"gene_indices_start":[36,51],"gene_indices_end":[48,55],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7205,"text":"The 3' stem-loop is highly divergent in structure among species and lies immediately upstream of the binding site for Sm proteins .","gene":["Sm proteins"],"gene_indices_start":[118],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7206,"text":"The C-terminal domains ( CTDs ) of the RPase beta subunit and DNA primase ( dnaG protein ) were not only strongly homologous to each other but also considerably homologous to the RPase alpha , suggesting that an alpha subunit-like enzyme must have been commonly ancestral to core enzyme subunits and primase .","gene":["DNA primase","primase","core enzyme subunits","dnaG protein","RPase beta subunit","RPase alpha"],"gene_indices_start":[39,62,76,179,275,300],"gene_indices_end":[57,73,88,190,295,307],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7212,"text":"The arrangement of these cutoff-levels leads to a sensitivity of 85% at a specificity of 55% for Protein S100 when measured by RIA , and to a sensitivity of 77% at a specificity of 61% when measured by LIA .","gene":["Protein S100"],"gene_indices_start":[97],"gene_indices_end":[109],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7214,"text":"In the absence of Swi4 and Swi6 cell viability is lost , but can be regained by ectopic expression of the G1 cyclin encoding genes , CLN1 or CLN2 .","gene":["Swi6","CLN2","CLN1","Swi4","G1 cyclin encoding genes"],"gene_indices_start":[18,27,106,133,141],"gene_indices_end":[22,31,130,137,145],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7215,"text":"The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration .","gene":["lipid A monoclonal antibodies"],"gene_indices_start":[40],"gene_indices_end":[69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7217,"text":"HBx strongly elevates levels of GTP-bound Ras , activated and phosphorylated Raf , and tyrosine-phosphorylated and activated MAP kinase .","gene":["Ras","HBx","MAP kinase","Raf"],"gene_indices_start":[0,42,77,125],"gene_indices_end":[3,45,80,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7218,"text":"These studies indicate that in vitro and in vivo electrical stimulation generate reactive oxygen species and affect SOD activity , which in part are responsible for decreased sperm motion and viability .","gene":["SOD"],"gene_indices_start":[116],"gene_indices_end":[119],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7219,"text":"In addition , the DNA-binding experiments show that either one of the two MADS domains of a dimer can be sufficient to confer a particular DNA-binding specificity to the complex and that sequences outside the amino-terminal basic region of the MADS domain can , in some cases , contribute to the DNA-binding specificity of the proteins .","gene":["MADS domains","MADS"],"gene_indices_start":[74,244],"gene_indices_end":[86,248],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7220,"text":"Finally , the mechanism of ASK1 activation involves , in part , homo-oligomerization .","gene":["ASK1"],"gene_indices_start":[27],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7221,"text":"A third one is homologous in half of its length to the prokaryotic hydantoinase HyuA and in the other half to hydatoinase HyuB .","gene":["hydatoinase","prokaryotic hydantoinase","HyuA","HyuB"],"gene_indices_start":[55,80,110,122],"gene_indices_end":[79,84,121,126],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7223,"text":"In addition serum IgE concentrations were not statistically different .","gene":["serum IgE"],"gene_indices_start":[12],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7224,"text":"Our results demonstrate that distinct cytoplasmic domains of these cytokine receptors elicit convergent signaling pathways and provide evidence that beta c and IL-2R beta function as a complete signal transducer .","gene":["IL-2R beta","cytokine receptors","beta c"],"gene_indices_start":[67,149,160],"gene_indices_end":[85,155,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7225,"text":"H-7 , which specifically , although weakly , inhibited PKC activation , had no effect on tyrosine phosphorylation and PtdIns ( 3 , 4 ) P2 production .","gene":["PKC"],"gene_indices_start":[55],"gene_indices_end":[58],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7230,"text":"Saccharomyces cerevisiae contains four known acyl-CoA synthetases ( fatty acid activation proteins , Faaps ) .","gene":["fatty acid activation proteins","acyl-CoA synthetases","Faaps"],"gene_indices_start":[45,68,101],"gene_indices_end":[65,98,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7233,"text":"In both shoots and roots , GT-2 protein is undetectable in meristematic tissue but becomes expressed at later stages of cellular development , consistent with a role in contributing to the pattern of phytochrome A gene expression .","gene":["phytochrome A gene","GT-2 protein"],"gene_indices_start":[27,200],"gene_indices_end":[39,218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7235,"text":"A cDNA library of tumour cells was screened with an interleukin 2 gene-specific probe .","gene":["interleukin 2"],"gene_indices_start":[52],"gene_indices_end":[65],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7236,"text":"An element within the 5' untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation .","gene":["human Hsp70 mRNA"],"gene_indices_start":[48],"gene_indices_end":[64],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7239,"text":"The coordinated expression of CD4 and CD8 during T-cell development is tightly coupled with the maturation state of the T cell .","gene":["CD8","CD4"],"gene_indices_start":[30,38],"gene_indices_end":[33,41],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7240,"text":"In contrast , recent evidence suggests that children with sickle-hemoglobin C disease do not develop functional asplenia before 3 to 4 years of age and thus may not benefit from penicillin prophylaxis .","gene":["sickle-hemoglobin C"],"gene_indices_start":[58],"gene_indices_end":[77],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7242,"text":"Imaging of D2 dopamine receptor .","gene":["D2 dopamine receptor"],"gene_indices_start":[11],"gene_indices_end":[31],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7247,"text":"RESULTS : In the AGA group , both fetal and maternal serum prolactin concentration increased significantly with gestation ( P < 0 . 001 and P < 0 . 01 , respectively ) .","gene":["prolactin"],"gene_indices_start":[59],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7251,"text":"Assembly of a complex between FAK and Src kinases may serve to regulate the subcellular localization and the enzymatic activity of members of the Src family of kinases .","gene":["FAK","Src family","Src kinases","kinases"],"gene_indices_start":[30,38,146,160],"gene_indices_end":[33,49,156,167],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7253,"text":"Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity .","gene":["transcription factor YY1","Rous sarcoma virus long terminal repeat promoter"],"gene_indices_start":[53,81],"gene_indices_end":[77,129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7254,"text":"Some 8 . 8 kb of the Lactobacillus sake plasmid pCIM1 was sequenced , revealing eight tightly clustered open reading frames ( ORFs ) downstream from lasA , which encodes pre-lactocin S .","gene":["pre-lactocin","lasA"],"gene_indices_start":[149,170],"gene_indices_end":[153,182],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7256,"text":"Until now , each of these loci was considered to contain three genes ( for regulator , permease and alpha-glucosidase ) , but a fourth gene , presumably an extra alpha-glucosidase gene , was found at MAL1 adjacent to the usual cluster of three genes .","gene":["alpha-glucosidase gene","alpha-glucosidase","MAL1","permease","regulator"],"gene_indices_start":[75,87,100,162,200],"gene_indices_end":[84,95,117,184,204],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7258,"text":"INF-alpha therapy has been a major development in the treatment of CML .","gene":["INF-alpha"],"gene_indices_start":[0],"gene_indices_end":[9],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7260,"text":"The cAMP-dependent mitogenic pathway is unique as it is independent of mitogen-activated protein kinase activation and differs from growth factor-dependent pathways at the level of the expression of several protooncogenes \/ transcription factors .","gene":["mitogen-activated protein kinase"],"gene_indices_start":[71],"gene_indices_end":[103],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7261,"text":"If NCR-sensitive gene expression occurs exclusively by this pathway , as has been thought to be the case , then the NCR sensitivity of a gene's expression should be abolished by a ure2 delta mutation .","gene":["ure2 delta mutation"],"gene_indices_start":[180],"gene_indices_end":[199],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7265,"text":"Four possible isoforms ( hGli2 alpha , beta , gamma , and delta ) are formed by combinations of two independent alternative splicings , and all the isoforms could bind to a DNA motif , TRE2S , in the LTR .","gene":["hGli2 alpha , beta , gamma , and delta","TRE2S"],"gene_indices_start":[25,185],"gene_indices_end":[63,190],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7266,"text":"When the E1A N-terminus is used as a competitor in squelshing experiments it abolishes CBP-induced activation of E2F1 \/ DP1 , whereas an E1A mutant lacking CBP binding ability fails to do so .","gene":["E1A mutant","CBP","E2F1 \/ DP1","E1A N-terminus"],"gene_indices_start":[9,113,137,156],"gene_indices_end":[23,123,147,159],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7267,"text":"Specialized actin tails that propel IEV particles to the periphery and virus-tipped microvilli ( both common in wild-type-infected cells ) were absent in cells infected with vA33delta .","gene":["actin"],"gene_indices_start":[12],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7270,"text":"TGF beta 1 expression is largely governed by three AP-1 binding sites located in two different promoters of this gene .","gene":["AP-1 binding sites","TGF beta 1"],"gene_indices_start":[0,51],"gene_indices_end":[10,69],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7276,"text":"Disruption of microtubules did not affect the fidelity or kinetics of vacuolar protein sorting , indicating that Vps1p function is not dependent on microtubules .","gene":["Vps1p"],"gene_indices_start":[113],"gene_indices_end":[118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7277,"text":"Transcription start sites of the plastid ACCase genes were estimated from the longest cDNA clones obtained by 5'-RACE ( rapid amplification of cDNA ends ) .","gene":["ACCase genes"],"gene_indices_start":[41],"gene_indices_end":[53],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7278,"text":"MKK3 autophosphorylation and activation of p38 was also observed following coexpression of MKK3 with MEKK3 , but not with MEKK2 .","gene":["MKK3","p38","MKK3","MEKK2","MEKK3"],"gene_indices_start":[0,43,91,101,122],"gene_indices_end":[4,46,95,106,127],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7283,"text":"Our analysis of nonsense mutations indicates that the C terminus of eIF2Bepsilon ( residues 518 to 712 ) is required for both catalytic activity and interaction with eIF2 .","gene":["eIF2","eIF2Bepsilon ( residues 518 to 712 )"],"gene_indices_start":[68,166],"gene_indices_end":[104,170],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7284,"text":"This study demonstrates that inducible expression in response to either PMA or TPO is mediated through the Ets site in the proximal promoter of GPIX and is dependent upon the upstream activation of MAPK \/ extracellular signal-regulated kinase .","gene":["Ets site","TPO","GPIX","MAPK","extracellular signal-regulated kinase"],"gene_indices_start":[79,107,144,198,205],"gene_indices_end":[82,115,148,202,242],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7286,"text":"In contrast , the loss of MAD2 staining in meiosis was not correlated with initial microtubule attachment but was correlated with a measure of tension : the distance between homologous or sister kinetochores ( in meiosis I and II , respectively ) .","gene":["MAD2"],"gene_indices_start":[26],"gene_indices_end":[30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7287,"text":"Furthermore , Rac1 activation of JNK or SRF , or induction of lamellipodia , was neither necessary nor sufficient for Rac1 transforming activity .","gene":["Rac1","JNK","SRF","Rac1"],"gene_indices_start":[14,33,40,118],"gene_indices_end":[18,36,43,122],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7288,"text":"It is suggested that the observed clinical phenomena in response to morphine can be explained by differences in expression and sensitivity of some opioid receptor subtypes in migraine .","gene":["opioid receptor"],"gene_indices_start":[147],"gene_indices_end":[162],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7291,"text":"The levels of galactosyltransferase activity in sera from normal children and patients with cystic fibrosis .","gene":["galactosyltransferase"],"gene_indices_start":[14],"gene_indices_end":[35],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7293,"text":"Since CENP-B gene is conserved in mammalian species and CENP-B boxes are found also in mouse centromere satellite DNA ( minor satellite ) , this sequence-specific DNA-protein interaction may be important for some kind of common centromere function .","gene":["CENP-B gene","CENP-B boxes"],"gene_indices_start":[6,56],"gene_indices_end":[17,68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7294,"text":"( 1989 ) , which is identical to the SSC1 gene ( Smith et al . , 1988 ) .","gene":["SSC1 gene"],"gene_indices_start":[37],"gene_indices_end":[46],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7295,"text":"The paper is concerned with the data on change in the blood level of ACTH , STH , TSH , cortisol , T3 , insulin , C-peptide during a 25-minute session of respiration using a gaseous hypoxic mixture with 10% oxygen ( GHM-10 ) .","gene":["STH , TSH","C-peptide","ACTH","insulin"],"gene_indices_start":[69,76,104,114],"gene_indices_end":[73,85,111,123],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7298,"text":"Blocked shift \/ supershift analysis indicates that Fos family member proteins especially Fra-1 and Fra-2 are related to progression and no changes found in the Jun family member proteins although they are present in the AP-1 \/ DNA binding complex .","gene":["AP-1 \/ DNA binding complex","Fra-2","Fra-1","Jun family","Fos family"],"gene_indices_start":[51,89,99,160,220],"gene_indices_end":[61,94,104,170,246],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7299,"text":"A strong trithorax binding site was found at the cytological location of the fork head gene , a region-specific homeotic gene not located within a homeotic complex .","gene":["homeotic gene","fork head gene","trithorax binding site","homeotic complex"],"gene_indices_start":[9,77,112,147],"gene_indices_end":[31,91,125,163],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7300,"text":"To investigate the regulation of Spec gene activity , the region around the Spec1 transcriptional initiation site was analyzed for sites of protein-DNA interaction .","gene":["Spec gene","Spec1 transcriptional initiation site"],"gene_indices_start":[33,76],"gene_indices_end":[42,113],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7301,"text":"In this study , we identified Sp1 and Sp3 as major factors binding to the Sp1 sites of the p21 \/ WAF1 \/ Cip1 promoter in MG63 cells through electrophoretic mobility shift assays and showed that TSA treatment did not change their binding activities .","gene":["Sp1 sites","Sp3","Sp1","p21 \/ WAF1 \/ Cip1 promoter"],"gene_indices_start":[30,38,74,91],"gene_indices_end":[33,41,83,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7307,"text":"Low affinity binding of Rab6A-GTP was also observed ( K ( d ) = 16 &mgr ; m ) , whereas Rab1B , -5 , -7 , -8 , or -11A did not bind .","gene":["Rab6A-GTP","Rab1B , -5 , -7 , -8 , or -11A"],"gene_indices_start":[24,88],"gene_indices_end":[33,118],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7308,"text":"CM-ACO3 is expressed in flowers and is not induced by any of the stimuli tested .","gene":["CM-ACO3"],"gene_indices_start":[0],"gene_indices_end":[7],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7310,"text":"PCR analysis indicates that this new beta-adducin isoform is expressed in fetal brain and liver , bone marrow , and NT-2 ( neuroepithelial ) cells , but is not detected in several other tissues .","gene":["beta-adducin isoform"],"gene_indices_start":[37],"gene_indices_end":[57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7311,"text":"Both PPC-1 and ALVA-31 cells display tumorigenesis and invasiveness in nude mice , whereas LNCap cells exhibit a less malignant phenotype , suggesting a correlation between CD44 variant ( CD44v ) expression and aggressive prostate tumor behavior .","gene":["CD44 variant","CD44v"],"gene_indices_start":[173,188],"gene_indices_end":[185,193],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7312,"text":"The mMIWC1 promoter was identified and contained TATA , CAAT , GATA , and AP-2 elements ; primer extension revealed mMIWC transcription initiation at 621 bp upstream from the mMIWC1 translational initiation site .","gene":["mMIWC","GATA","mMIWC1 promoter","AP-2 elements","mMIWC1"],"gene_indices_start":[4,63,74,116,175],"gene_indices_end":[19,67,87,121,181],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7313,"text":"RESULTS : CK-MB elevation was detected in 313 patients ( 18 . 7% ) , with 1-3x in 12 . 8% , 3-5x in 3 . 5% and > 5x normal in 2 . 4% of patients .","gene":["CK-MB"],"gene_indices_start":[10],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7315,"text":"This gene joins the group of genes whose members are rapidly transcribed in response to insulin and other mitogens .","gene":["insulin"],"gene_indices_start":[88],"gene_indices_end":[95],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7316,"text":"The deleted nucleotide sequence corresponded to sequences that , by analogy to the organization of the type I collagen genes , should be precisely encoded by exon 41 of the COL3A1 gene .","gene":["type I collagen genes","COL3A1 gene"],"gene_indices_start":[103,173],"gene_indices_end":[124,184],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7317,"text":"A highly significant correlation was found between the presence of fibrinolytic degradation products ( FDP ) and the incidence of nephropathy and renal insufficiency , as well as between the presence of fibrin monomers ( Godal's ethanol-gelification test ) and the evolutive signs of the primary disease ( fever , accelerated ESR ) .","gene":["fibrin monomers"],"gene_indices_start":[203],"gene_indices_end":[218],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7319,"text":"Neurospora crassa CYT-18 , can rescue the exonic trap and intron mutants which cause a structural defect .","gene":["CYT-18"],"gene_indices_start":[18],"gene_indices_end":[24],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7321,"text":"Previous work showed that repA ( initiator protein ) expression requires tap ( leader peptide ) translation .","gene":["leader peptide","initiator protein","tap","repA"],"gene_indices_start":[26,33,73,79],"gene_indices_end":[30,50,76,93],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7322,"text":"In addition , IgM can be absent in children with congenital toxoplasmosis or subjects with secondary reactivation .","gene":["IgM"],"gene_indices_start":[14],"gene_indices_end":[17],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7323,"text":"The high level of transformation-associated deletions in the human YACs was reduced over 10-fold when the host was a recombination-deficient strain deleted for the RAD52 gene .","gene":["RAD52 gene"],"gene_indices_start":[164],"gene_indices_end":[174],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7324,"text":"Notably , SRF has been found to be a key regulator of members of a class of cellular response genes termed immediate-early genes ( IEGs ) , many of which are believed to be involved in regulating cell growth and differentiation .","gene":["SRF","IEGs","immediate-early genes"],"gene_indices_start":[10,107,131],"gene_indices_end":[13,128,135],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7325,"text":"Total body water , rhodanide space and I-131-albumin space under the acute effect of furosemide .","gene":["I-131-albumin"],"gene_indices_start":[39],"gene_indices_end":[52],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7326,"text":"Furthermore , an upstream element , collagen element I ( -370 \/ -344 ) , which shares homology with the LAP binding cis-element of the albumin promoter ( 9 of 13 bp ) is described .","gene":["collagen element I ( -370 \/ -344 )","LAP","albumin promoter"],"gene_indices_start":[36,104,135],"gene_indices_end":[70,107,151],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7328,"text":"The Oct-3 \/ 4 gene product , which belongs to the POU family of transcription factors , is a good candidate for regulating initial differentiation decisions .","gene":["POU family of transcription factors","Oct-3 \/ 4 gene product"],"gene_indices_start":[4,50],"gene_indices_end":[26,85],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7330,"text":"Value of Normotest and antithrombin 3 in the assessment of liver function .","gene":["antithrombin 3"],"gene_indices_start":[23],"gene_indices_end":[37],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7332,"text":"Recombinant Ffh has a melting point of tm = 89 degreesC .","gene":["Recombinant Ffh"],"gene_indices_start":[0],"gene_indices_end":[15],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7336,"text":"MOP5 contained the characteristic PAS domain and a variable C terminus ; it is possible that the cDNA contains a bHLH domain , but the entire open reading frame has yet to be completed .","gene":["bHLH","MOP5","PAS domain"],"gene_indices_start":[0,34,113],"gene_indices_end":[4,44,117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7342,"text":"Co-immunoprecipitation and DNA affinity chromatography prove that Sp1 heterodimerizes with ZBP-89 when bound to the silencer element to yield a DNA-protein complex whose mobility is indistinguishable from that displayed by HeLa nuclear extract in band shift assays .","gene":["Sp1","ZBP-89"],"gene_indices_start":[66,91],"gene_indices_end":[69,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7343,"text":"The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin .","gene":["beta2AR","GRK2","GRK5 phosphoacceptor sites","rhodopsin"],"gene_indices_start":[25,34,101,167],"gene_indices_end":[29,60,108,176],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7347,"text":"This last region contains two sites that bind Ets-related proteins present in liver nuclear extracts as well as recombinant purified Ets-1 protein .","gene":["recombinant purified Ets-1 protein","Ets-related proteins"],"gene_indices_start":[46,112],"gene_indices_end":[66,146],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7348,"text":"Sequence analysis of the promoter region showed no TATA box but identified consensus binding motifs for Sp1 , CREB , and half sites of the estrogen receptor binding site .","gene":["estrogen receptor binding site","CREB","Sp1"],"gene_indices_start":[104,110,139],"gene_indices_end":[107,114,169],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7350,"text":"Cytohesin-1 , a protein abundant in cells of the immune system , has been proposed to be a human homolog of the Saccharomyces cerevisiae Sec7 gene product , which is crucial in protein transport .","gene":["Cytohesin-1","Saccharomyces cerevisiae Sec7 gene product"],"gene_indices_start":[0,112],"gene_indices_end":[11,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7352,"text":"Transcriptional activation by the HIV-1 Tat protein requires specific residues in the hexanucleotide loop and trinucleotide bulge of the TAR RNA stem-loop structure found in the 5'-untranslated leader of all viral transcripts .","gene":["HIV-1 Tat protein","TAR RNA"],"gene_indices_start":[34,137],"gene_indices_end":[51,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7353,"text":"Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic , acid-stimulated mitogenic activity in L cells .","gene":["platelet-derived growth factor receptor"],"gene_indices_start":[33],"gene_indices_end":[72],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7354,"text":"The general transcription factor IIA ( TFIIA ) interacts with the TATA binding protein ( TBP ) and promoter DNA to mediate transcription activation in vitro .","gene":["TBP","TFIIA","transcription factor IIA","TATA binding protein"],"gene_indices_start":[12,39,66,89],"gene_indices_end":[36,44,86,92],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7356,"text":"These findings suggest a functional cross-talk between RB protein and p21ras , which balances the cell phenotype between normal and transformed states .","gene":["RB protein","p21ras"],"gene_indices_start":[55,70],"gene_indices_end":[65,76],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7357,"text":"Previous studies have demonstrated that tissue-restricted transcription factors including PU . 1 and PU . 1 interaction partner ( PIP ) function synergistically with c-Fos plus c-Jun to stimulate the kappaE3'-enhancer in 3T3 cells .","gene":["PIP","c-Jun","PU . 1 interaction partner","kappaE3'-enhancer","c-Fos","PU . 1"],"gene_indices_start":[90,101,130,166,177,200],"gene_indices_end":[96,127,133,171,182,217],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7358,"text":"The origins of reflected light changes associated with neuronal activity ( optical signals ) were investigated in rat somatosensory cortex with optical imaging , microspectrophotometry , and laser-Doppler flowmetry , and dynamic changes in local hemoglobin concentration and oxygenation were focused on .","gene":["hemoglobin"],"gene_indices_start":[246],"gene_indices_end":[256],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7361,"text":"These observations , together with the occurrence of putative 4'-phosphopantetheine-attachment sites and a putative thioesterase site , are discussed with reference to the reaction sequence leading to production of the ACV tripeptide .","gene":["thioesterase site","ACV tripeptide"],"gene_indices_start":[116,219],"gene_indices_end":[133,233],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7364,"text":"A striking finding in all of the studies was a positive correlation between PI ACTH and MSH contents .","gene":["ACTH","MSH"],"gene_indices_start":[79,88],"gene_indices_end":[83,91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7365,"text":"The capacity to repair 8-OxoG has been measured in cell-free extracts of wild-type and ogg1 strains using a 34mer DNA fragment containing a single 8-OxoG residue paired with a cytosine ( 8-OxoG \/ C ) as a substrate .","gene":["ogg1"],"gene_indices_start":[87],"gene_indices_end":[91],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7367,"text":"VirD2 is one of the key Agrobacterium tumefaciens proteins involved in T-DNA processing and transfer .","gene":["VirD2"],"gene_indices_start":[0],"gene_indices_end":[5],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7368,"text":"The dnaK operon of Bacillus subtilis is heptacistronic .","gene":["dnaK operon of Bacillus subtilis"],"gene_indices_start":[4],"gene_indices_end":[36],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7370,"text":"Alterations in DNase I reactivity of the GC-response element region suggest that GC receptor-GC complexes may associate , in a transient manner , with the promoter in the actively transcribing control state .","gene":["GC receptor-GC complexes","DNase I"],"gene_indices_start":[15,81],"gene_indices_end":[22,105],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7371,"text":"Reconstitution of complexes containing p62 and the src family kinase p59fyn in HeLa cells demonstrated that complex formation resulted in tyrosine phosphorylation of p62 and was mediated by both the SH3 and SH2 domains of p59fyn .","gene":["SH2 domains","src family kinase","SH3","p59fyn","p62","p62","p59fyn"],"gene_indices_start":[39,51,69,166,199,207,222],"gene_indices_end":[42,68,75,169,202,218,228],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7372,"text":"Sixteen out of 52 seropositive MS patients ( 30 . 8% ) showed intrathecal synthesis of C . pneumoniae-specific IgG but only one of 43 seropositive controls ( 2 . 3% ) .","gene":["C . pneumoniae-specific IgG"],"gene_indices_start":[87],"gene_indices_end":[114],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7373,"text":"The N-terminus of another open reading frame was found 3' from nifA and tentatively identified as nifB by amino acid sequence comparison .","gene":["nifA","nifB"],"gene_indices_start":[63,98],"gene_indices_end":[67,102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7374,"text":"Phosphatidylinositol 3-kinase requirement in activation of the ras \/ C-raf-1 \/ MEK \/ ERK and p70 ( s6k ) signaling cascade by the insulinomimetic agent vanadyl sulfate .","gene":["Phosphatidylinositol 3-kinase","ras \/ C-raf-1 \/ MEK \/ ERK","p70 ( s6k )"],"gene_indices_start":[0,63,93],"gene_indices_end":[29,88,104],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7376,"text":"In addition to homologues of the human genes PSMB5 through PSMB9 , two new genes , PSMB11 and PSMB12 , have been found for which there are no known corresponding genes in humans .","gene":["PSMB9","human genes PSMB5","PSMB11","PSMB12"],"gene_indices_start":[33,59,83,94],"gene_indices_end":[50,64,89,100],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7377,"text":"We conclude that the conservation of nucleotides 154 to 156 is likely to be a consequence of their role as a sequence-specific recognition element for the SRP54 protein .","gene":["SRP54 protein"],"gene_indices_start":[155],"gene_indices_end":[168],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7378,"text":"The genetic basis for the expression of a latent VH allotype in the rabbit was investigated .","gene":["VH allotype"],"gene_indices_start":[49],"gene_indices_end":[60],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7382,"text":"Unexpectedly , Arg1-expressing COS1 cells showed no significant proteinase activity to various synthesized substrates under neutral or acidic conditions in this study .","gene":["proteinase"],"gene_indices_start":[64],"gene_indices_end":[74],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7384,"text":"Effects of a perfluorochemical blood substitute on diazepam binding by human albumin .","gene":["human albumin"],"gene_indices_start":[71],"gene_indices_end":[84],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7385,"text":"These findings suggest one potential mechanism for direct recruitment of distal regulatory regions of the globin loci to the individual promoters .","gene":["globin loci"],"gene_indices_start":[106],"gene_indices_end":[117],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7386,"text":"GETS-1 is expressed in many tissues , but is enriched in retina and brain .","gene":["GETS-1"],"gene_indices_start":[0],"gene_indices_end":[6],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7387,"text":"A second isotype of Raja immunoglobulin heavy chain genes has been detected by screening a spleen cDNA library with homologous Raja VH- and CH1-specific probes complementing the respective regions of the mu-like isotype .","gene":["mu-like isotype","Raja immunoglobulin heavy chain genes"],"gene_indices_start":[20,204],"gene_indices_end":[57,219],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7389,"text":"Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4 \/ MTS1 tumour suppressor gene product .","gene":["cyclin D-Cdk complexes","p16INK4","MTS1"],"gene_indices_start":[8,83,93],"gene_indices_end":[30,90,97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7392,"text":"This study examines the cooperative effects of a human estrogen receptor-alpha ( ERalpha ) isoform on estrogen ( E2 ) -mediated gene activation in U2-OS osteosarcoma cells .","gene":["estrogen receptor-alpha","ERalpha","E2","estrogen"],"gene_indices_start":[55,81,102,113],"gene_indices_end":[78,88,110,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7393,"text":"Three mog-1 alleles possess premature stop codons and are likely to be null alleles , and one is a missense mutation and is likely to retain residual activity . mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous .","gene":["mog-1 mRNA","mog-1 alleles"],"gene_indices_start":[6,161],"gene_indices_end":[19,171],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7395,"text":"Marked hemolysis significantly increased plasma values of potassium , phosphorus , total protein , and aspartate aminotransferase .","gene":["aspartate aminotransferase"],"gene_indices_start":[103],"gene_indices_end":[129],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7398,"text":"Blood from dams was collected prior to inoculation and at time of necropsy for measurement of IgM and IgG antibodies to M . pulmonis .","gene":["IgG antibodies","IgM"],"gene_indices_start":[94,102],"gene_indices_end":[97,116],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7404,"text":"In HeLa cells , the JNKK2-JNK1 fusion protein showed significant JNK activity , which was comparable with that of JNK1 activated by many stimuli and activators , including EGF , TNF-alpha , anisomycin , UV irradiation , MEKK1 , and small GTP binding proteins Rac1 and Cdc42Hs .","gene":["small GTP binding proteins Rac1","EGF","JNK1","MEKK1","Cdc42Hs","JNKK2-JNK1 fusion protein","TNF-alpha","JNK"],"gene_indices_start":[20,65,114,172,178,220,232,268],"gene_indices_end":[45,68,118,175,187,225,263,275],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7405,"text":"In some early B cells and Abelson murine leukemia virus-transformed pre-B-cell lines , LT mRNA is constitutively expressed .","gene":["LT mRNA"],"gene_indices_start":[87],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7406,"text":"Substitution of bulky hydrophobic residues with charged residues within PEP1 affects the fusion activity of the S protein without affecting processing and surface expression .","gene":["PEP1","S protein"],"gene_indices_start":[72,112],"gene_indices_end":[76,121],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7409,"text":"In this study , a common mechanism has been identified to coordinate the growth- and FC-dependent expression of caveolin .","gene":["caveolin"],"gene_indices_start":[112],"gene_indices_end":[120],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7411,"text":"SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5' end of Caenorhabditis elegans pre-mRNA .","gene":["SL1"],"gene_indices_start":[0],"gene_indices_end":[3],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7415,"text":"ENV also was secreted from P . pastoris using the S . cerevisiae alpha-factor prepro secretion leader and the S . cerevisiae invertase signal sequence .","gene":["S . cerevisiae alpha-factor prepro secretion leader","S . cerevisiae invertase signal sequence","ENV"],"gene_indices_start":[0,50,110],"gene_indices_end":[3,101,150],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7418,"text":"Accordingly , no Ha-ras codon 12 mutations are found in the EtNU-induced mammary tumors .","gene":["Ha-ras codon 12"],"gene_indices_start":[17],"gene_indices_end":[32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7419,"text":"The sequence and isolated cDNAs will provide useful reagents for studying the expression of Brca1 in the mouse , and for testing the importance of the evolutionarily conserved domains .","gene":["Brca1"],"gene_indices_start":[92],"gene_indices_end":[97],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7422,"text":"A mouse brain beta-spectrin of cDNA was identified within a lambda Gt11 expression library using an antibody which specifically binds with the 235 kDa spectrin beta-subunit .","gene":["mouse brain beta-spectrin","235 kDa spectrin beta-subunit"],"gene_indices_start":[2,143],"gene_indices_end":[27,172],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7424,"text":"Antibodies specific to rE12 and rNFIL-6 disrupt nucleoprotein complexes with these DNA-binding sites , confirming the interaction of native in vivo factors .","gene":["rNFIL-6","rE12"],"gene_indices_start":[23,32],"gene_indices_end":[27,39],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7430,"text":"Human thyroid stimulator ( HTS ) in thyroid diseases .","gene":["HTS","Human thyroid stimulator"],"gene_indices_start":[0,27],"gene_indices_end":[24,30],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7431,"text":"Substituting a Ser for Gly69 or a Glu for Lys 71 in the conserved TGEK tetrapeptide in finger II of TFIIIA resulted in the loss of DNA binding .","gene":["TGEK tetrapeptide","TFIIIA"],"gene_indices_start":[66,100],"gene_indices_end":[83,106],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7432,"text":"Plasma thrombomodulin : a marker for microvascular complications in diabetes mellitus .","gene":["thrombomodulin"],"gene_indices_start":[7],"gene_indices_end":[21],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7433,"text":"Thus , the L45 sequence between kinase subdomains IV and V specifies TGF-beta responsiveness of the type I receptor .","gene":["L45 sequence","kinase subdomains IV and V","TGF-beta","type I receptor"],"gene_indices_start":[11,32,69,100],"gene_indices_end":[23,58,77,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7434,"text":"We have cloned and sequenced a region encoding a lipase operon and a putative , previously uncharacterized metalloprotease of Vibrio cholerae O1 .","gene":["lipase operon","metalloprotease of Vibrio cholerae O1"],"gene_indices_start":[49,107],"gene_indices_end":[62,144],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7435,"text":"Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit .","gene":["integrin beta 1 subunit"],"gene_indices_start":[105],"gene_indices_end":[128],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7436,"text":"In addition , the transcription of c-IAP2 promoter was strongly up-regulated when CD40 or Epstein-Barr virus latent membrane protein 1 was overexpressed .","gene":["Epstein-Barr virus latent membrane protein 1","CD40","c-IAP2 promoter"],"gene_indices_start":[35,82,90],"gene_indices_end":[50,86,134],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7437,"text":"A local , high-density , single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1 .","gene":["Caenorhabditis elegans cdf-1"],"gene_indices_start":[74],"gene_indices_end":[102],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7440,"text":"Fentanyl , a prototypic mu-opiate receptor agonist , has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia , tachypnoea and behavioural arousal .","gene":["mu-opiate receptor"],"gene_indices_start":[24],"gene_indices_end":[42],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7442,"text":"Once P-450scc mRNA is induced as a consequence of the LH \/ hCG surge it is constitutively maintained by luteinized cells in vivo ( 0-4 days ) and in vitro ( 0-9 days ) in the absence of gonadotropins , is susceptible to modulation by prolactin and is no longer regulated by cAMP .","gene":["prolactin","P-450scc mRNA","LH \/ hCG","gonadotropins"],"gene_indices_start":[5,54,186,234],"gene_indices_end":[18,62,199,243],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7444,"text":"A positive correlation between serum myoglobin and CA III concentrations ( rs = 0 . 933 , P < 0 . 001 ) was observed in hemodialyzed patients with chronic renal failure .","gene":["serum myoglobin","CA III"],"gene_indices_start":[31,51],"gene_indices_end":[46,57],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7446,"text":"Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum .","gene":["47-kilodalton major integral membrane immunogen of Treponema pallidum"],"gene_indices_start":[25],"gene_indices_end":[94],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7447,"text":"By using total-protein extracts from mycelia grown under penicillin producing conditions we have detected a DNA-binding activity that specifically shifts a promoter fragment located between -654 and -455 ( relative to IPNS tsp ) .","gene":["IPNS tsp"],"gene_indices_start":[218],"gene_indices_end":[226],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7450,"text":"Hb levels remained adequate ( Hb = 10 . 68 + \/ - 0 . 77 g \/ dl ) after 14 . 6 + \/ - 7 . 64 months .","gene":["Hb","Hb"],"gene_indices_start":[0,30],"gene_indices_end":[2,32],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7452,"text":"An unusual cysteine triplet conserved in the sequences of TB domains is localized to the hydrophobic core , at the C-terminus of an alpha-helix .","gene":["TB domains"],"gene_indices_start":[58],"gene_indices_end":[68],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7455,"text":"Prostate specific antigen shows the metastatic cases better [ correction of worse ] than prostatic acid phosphatase .","gene":["prostatic acid phosphatase","Prostate specific antigen"],"gene_indices_start":[0,89],"gene_indices_end":[25,115],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":7457,"text":"The cwg2-1 mutation was identified as a guanine to adenine substitution at nucleotide 604 of the coding region , originating the change A202T in the cwg2p .","gene":["cwg2p","cwg2-1 mutation"],"gene_indices_start":[4,149],"gene_indices_end":[19,154],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1639,"text":"Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. A series of benzoxazole compounds containing oxamic acid were synthesized and screened for the PTP1B inhibition. Compound 31d showed best biochemical potency (Ki) of 6.7\u03bcM. Structure-activity relationship were explained with the help of molecular modeling approach.","gene":["PTP1B","PTP1B"],"gene_indices_start":[60,173],"gene_indices_end":[65,178],"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["benzoxazole","oxamic acid","2-substituted benzoxazoles"],"drug_indices_start":[24,90,123],"drug_indices_end":[50,101,134]}
{"index":2,"text":"He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","cyclophosphamide","actinomycin-D"],"drug_indices_start":[66,80,98],"drug_indices_end":[77,93,114]}
{"index":3,"text":"However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","vincristine","prednisolone","adriamycin"],"drug_indices_start":[117,136,149,167],"drug_indices_end":[133,146,160,179]}
{"index":4,"text":"Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","amiodarone"],"drug_indices_start":[38,86],"drug_indices_end":[49,96]}
{"index":5,"text":"We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Curcumin","Somatostatin","Quercetin"],"drug_indices_start":[63,76,127],"drug_indices_end":[71,85,139]}
{"index":6,"text":"Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["moxifloxacin","tobramycin"],"drug_indices_start":[56,79],"drug_indices_end":[68,89]}
{"index":7,"text":"Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","nystatin","cetuximab","cetuximab"],"drug_indices_start":[27,41,72,159],"drug_indices_end":[36,49,81,168]}
{"index":8,"text":"The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chenodeoxycholic","simvastatin"],"drug_indices_start":[40,75],"drug_indices_end":[56,86]}
{"index":9,"text":"Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","paclitaxel","anthracyclines"],"drug_indices_start":[0,268,283],"drug_indices_end":[10,278,297]}
{"index":10,"text":"However , anastrozole , exemestane and letrozole are associated with significantly fewer endometrial cancers , as well as venous and arterial vascular events , when compared with tamoxifen [ 9 , 10 ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","exemestane","letrozole","tamoxifen"],"drug_indices_start":[10,24,39,179],"drug_indices_end":[21,34,48,188]}
{"index":11,"text":"Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rapamycin","doxorubicin","paclitaxel","MIS","AzadC"],"drug_indices_start":[56,64,76,84,114],"drug_indices_end":[59,73,81,95,124]}
{"index":12,"text":"There was no cytotoxic effect of cisplatin , ifosfamide , and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","etoposide"],"drug_indices_start":[45,62],"drug_indices_end":[55,71]}
{"index":13,"text":"Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding bevacizumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","bevacizumab"],"drug_indices_start":[226,302],"drug_indices_end":[236,313]}
{"index":14,"text":"The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent\/refractory AML .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["topotecan","cladribine","topotecan"],"drug_indices_start":[90,154,187],"drug_indices_end":[99,164,196]}
{"index":15,"text":"The management of EP is challenging : no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first-line therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine","infliximab"],"drug_indices_start":[98,114],"drug_indices_end":[110,124]}
{"index":16,"text":"As single agents , curcumin and metformin are reported to exhibit chemopreventive properties , in vitro as well as in patients with oral cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","metformin"],"drug_indices_start":[19,32],"drug_indices_end":[27,41]}
{"index":17,"text":"Withdrawal rates were comparable to drug survival rates of other biological therapies and rates of adverse events were similar between brodalumab and ustekinumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["brodalumab","ustekinumab"],"drug_indices_start":[135,150],"drug_indices_end":[145,161]}
{"index":18,"text":"In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mycophenolate","cyclophosphamide","corticosteroids","mofetil"],"drug_indices_start":[46,126,140,164],"drug_indices_end":[61,139,147,180]}
{"index":19,"text":"Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","mitoxantrone","paclitaxel"],"drug_indices_start":[124,153,200],"drug_indices_end":[140,165,210]}
{"index":20,"text":"These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["flutamide","bicalutamide"],"drug_indices_start":[81,95],"drug_indices_end":[90,107]}
{"index":21,"text":"We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","trastuzumab"],"drug_indices_start":[48,63],"drug_indices_end":[58,74]}
{"index":22,"text":"Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","clopidogrel"],"drug_indices_start":[31,43],"drug_indices_end":[38,54]}
{"index":23,"text":"Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["apalutamide","enzalutamide","ADT"],"drug_indices_start":[122,138,183],"drug_indices_end":[133,150,186]}
{"index":25,"text":"Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ixazomib","Fulvestrant","Fulvestrant"],"drug_indices_start":[48,73,130],"drug_indices_end":[56,84,141]}
{"index":26,"text":"Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Trastuzumab","Lapatinib"],"drug_indices_start":[66,100],"drug_indices_end":[77,109]}
{"index":27,"text":"Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alemtuzumab","rituximab","alemtuzumab"],"drug_indices_start":[175,191,250],"drug_indices_end":[186,200,261]}
{"index":28,"text":"Furthermore , the overall response rate for docetaxel in the intent-to-treat population ( 42.5 % ) is superior to the response rate of either doxorubicin as second-line therapy ( 29.3 % ) or paclitaxel ( Taxol ; Bristol-Myers Squibb Oncology , Princeton , NJ ) when used as first- or second-line therapy ( 29 % ) in metastatic disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","doxorubicin","paclitaxel"],"drug_indices_start":[44,142,191],"drug_indices_end":[53,153,201]}
{"index":29,"text":"Correlation of lidocaine induced changes in bladder capacity , compliance and number of uninhibited contractions with improvement on oral oxybutynin was 70.6 % , 64.3 % and 66.7 % , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lidocaine","oxybutynin"],"drug_indices_start":[15,138],"drug_indices_end":[24,148]}
{"index":30,"text":"Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["risedronate","risedronate","atorvastatin"],"drug_indices_start":[14,48,65],"drug_indices_end":[25,59,77]}
{"index":31,"text":"The anti-CD22 immunoconjugate , inotuzumab ozogamicin , and the anti-CD19 BiTE ( \u00ae ) antibody , blinatumomab , have demonstrated impressive single agent activity in patients with relapsed or refractory B-ALL .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ozogamicin","blinatumomab"],"drug_indices_start":[43,96],"drug_indices_end":[53,108]}
{"index":32,"text":"Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg\/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg\/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","capecitabine"],"drug_indices_start":[135,200],"drug_indices_end":[146,212]}
{"index":33,"text":"Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg\/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[89,129],"drug_indices_end":[99,140]}
{"index":34,"text":"With regard to efficacy in metastatic disease , exemestane is superior to megestrol acetate after progression on tamoxifen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["exemestane","megestrol","tamoxifen"],"drug_indices_start":[48,74,113],"drug_indices_end":[58,83,122]}
{"index":35,"text":"Aim of the study was to measure plasma levels of specific miRNAs ( miRNA-223 , -150 , -21 and -126 ) after physician-driven cessation of chronic P2Y12 inhibition and to study differences in the expression levels of these miRNAs between the different oral P2Y12 inhibitors clopidogrel , prasugrel and ticagrelor , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clopidogrel","prasugrel","ticagrelor"],"drug_indices_start":[272,286,300],"drug_indices_end":[283,295,310]}
{"index":36,"text":"Eligible patients received ramucirumab ( 10mg\/kg ) + dacarbazine ( 1000 mg\/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg\/kg ) ( Arm B ) every 3 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ramucirumab","dacarbazine","ramucirumab"],"drug_indices_start":[27,53,96],"drug_indices_end":[38,64,107]}
{"index":37,"text":"The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["apigenin","cyclophosphamide","doxorubicin"],"drug_indices_start":[119,182,203],"drug_indices_end":[127,198,214]}
{"index":38,"text":"The novel agents , romidepsin , pralatrexate , and brentuximab vedotin , are currently approved in the relapsed\/refractory setting .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["romidepsin","pralatrexate","vedotin"],"drug_indices_start":[19,32,63],"drug_indices_end":[29,44,70]}
{"index":39,"text":"More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I\/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","platinum","fluorouracil"],"drug_indices_start":[160,172,187],"drug_indices_end":[169,180,199]}
{"index":40,"text":"Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Gemcitabine","cyclosporine","tacrolimus"],"drug_indices_start":[0,17,38],"drug_indices_end":[11,29,48]}
{"index":41,"text":"Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Erythropoietin","trastuzumab"],"drug_indices_start":[0,61],"drug_indices_end":[14,72]}
{"index":42,"text":"Both paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) and ifosfamide have been demonstrated to be active agents in patients with clinically defined platinum-refractory ovarian cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","ifosfamide"],"drug_indices_start":[5,78],"drug_indices_end":[15,88]}
{"index":43,"text":"All M. simiae complex species proved susceptible to clarithromycin and , to a lesser extent , rifabutin , clofazimine , streptomycin and moxifloxacin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clarithromycin","rifabutin","clofazimine","streptomycin","moxifloxacin"],"drug_indices_start":[52,94,106,120,137],"drug_indices_end":[66,103,117,132,149]}
{"index":44,"text":"Drug exposure of mesenchymal HCC cells showed higher resistance to the targeted therapeutic agents sorafenib and erlotinib as compared to epithelial HCC cells , which were slightly more resistant to cytostatic drugs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","erlotinib"],"drug_indices_start":[99,113],"drug_indices_end":[108,122]}
{"index":45,"text":"To compare the effectiveness and safety of adalimumab and infliximab in biologic-na\u00efve patients with CD , in a nationwide register-based propensity score-matched cohort study in Denmark .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["adalimumab","infliximab"],"drug_indices_start":[43,58],"drug_indices_end":[53,68]}
{"index":46,"text":"Hematologic National Cancer Institute Common Toxicity Criteria grade 3 to 4 adverse events were more common with bendamustine than with chlorambucil ( occurring in 40 % v 19 % of patients ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bendamustine","chlorambucil"],"drug_indices_start":[113,136],"drug_indices_end":[125,148]}
{"index":47,"text":"We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["diclofenac","octreotide"],"drug_indices_start":[29,49],"drug_indices_end":[39,59]}
{"index":48,"text":"Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Caspofungin","amphotericin"],"drug_indices_start":[0,16],"drug_indices_end":[11,28]}
{"index":49,"text":"Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["meglumine","allopurinol","amphotericin","meglumine","allopurinol","antimoniate"],"drug_indices_start":[63,73,87,101,138,164],"drug_indices_end":[72,84,98,113,147,175]}
{"index":50,"text":"Haloperidol , carbamazepine and levomepromazine were then discontinued .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Haloperidol","carbamazepine"],"drug_indices_start":[0,14],"drug_indices_end":[11,27]}
{"index":51,"text":"Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["quinidine","verapamil"],"drug_indices_start":[77,103],"drug_indices_end":[86,112]}
{"index":52,"text":"The mean duration of total ( i.v . and oral ) therapy was significantly shorter for the azithromycin group than for the cefuroxime group ( 6.2 days vs 10.1 days ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","cefuroxime"],"drug_indices_start":[88,120],"drug_indices_end":[100,130]}
{"index":53,"text":"To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E\/C ) - with respect to the standard combination ( EC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epirubicin","cyclophosphamide"],"drug_indices_start":[143,164],"drug_indices_end":[153,180]}
{"index":55,"text":"a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["estramustine","cyproterone","bromocriptine","estrogens"],"drug_indices_start":[26,51,74,89],"drug_indices_end":[38,62,83,102]}
{"index":56,"text":"Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["halothane","succinylcholine"],"drug_indices_start":[150,164],"drug_indices_end":[159,179]}
{"index":57,"text":"Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mitomycin","vinblastine"],"drug_indices_start":[0,17],"drug_indices_end":[9,28]}
{"index":58,"text":"An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olmesartan","azelnidipine"],"drug_indices_start":[43,88],"drug_indices_end":[53,100]}
{"index":60,"text":"At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","sorafenib","everolimus"],"drug_indices_start":[111,125,149],"drug_indices_end":[120,134,159]}
{"index":61,"text":"Failure to sedate patients who might be aware of paralysis occurred in three of 25 succinylcholine and eight of 94 pancuronium uses .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["succinylcholine","pancuronium"],"drug_indices_start":[83,115],"drug_indices_end":[98,126]}
{"index":62,"text":"Thirty-one isolates were classified as resistant to amprolium , 23 resistant to monensin , 10 resistant to diclazuril , and 6 resistant to clopidol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amprolium","diclazuril","clopidol"],"drug_indices_start":[52,107,139],"drug_indices_end":[61,117,147]}
{"index":63,"text":"Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lidocaine","dexamethasone","cystodistention"],"drug_indices_start":[138,152,178],"drug_indices_end":[147,165,193]}
{"index":64,"text":"Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["omega-3","niacin","colesevelam hydrochloride","ezetimibe","simvastatin"],"drug_indices_start":[22,58,67,128,148],"drug_indices_end":[29,64,92,137,159]}
{"index":65,"text":"Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg\/kg ) in Cycle 1 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","folinic acid","fluorouracil","fluorouracil","bevacizumab"],"drug_indices_start":[84,97,116,149,185],"drug_indices_end":[94,109,128,161,196]}
{"index":66,"text":"Patients received vinorelbine starting at 20 mg\/m(2 ) ( to 25 mg\/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinorelbine","carboplatin"],"drug_indices_start":[18,77],"drug_indices_end":[29,88]}
{"index":67,"text":"Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dexamethasone","paclitaxel"],"drug_indices_start":[0,46],"drug_indices_end":[13,56]}
{"index":68,"text":"The first available studies demonstrate the value of these compounds with an improved prognosis of metastatic patients in combination with endocrine therapy ( palbociclib , ribociclib ) or in monotherapy ( abemaciclib ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["palbociclib","ribociclib","abemaciclib"],"drug_indices_start":[159,173,206],"drug_indices_end":[170,183,217]}
{"index":69,"text":"Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Flunarizine","diltiazem"],"drug_indices_start":[0,110],"drug_indices_end":[11,119]}
{"index":72,"text":"These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methylprednisolone","mycophenolate","immunoglobulin"],"drug_indices_start":[99,122,211],"drug_indices_end":[117,135,225]}
{"index":73,"text":"The introduction of the selective serotonin reuptake inhibitors , moclobemide and mianserin has been a major advance in the treatment of depression , and is already leading to major shifts in the pattern of antidepressants prescribing .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["moclobemide","mianserin"],"drug_indices_start":[66,82],"drug_indices_end":[77,91]}
{"index":74,"text":"Four of these had equivocal plasma levels of both norepinephrine and epinephrine , suggesting that overnight clonidine suppression may be of particular value when tumor secretion is intermittent or low .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epinephrine","clonidine"],"drug_indices_start":[69,109],"drug_indices_end":[80,118]}
{"index":75,"text":"In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ATGAM","tacrolimus","steroids","cyclosporine"],"drug_indices_start":[43,53,126,139],"drug_indices_end":[48,63,134,151]}
{"index":76,"text":"Comparison of geometric least-squares mean PK parameters between arms showed no impact of pertuzumab on the PK of trastuzumab or docetaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertuzumab","trastuzumab","docetaxel"],"drug_indices_start":[90,114,129],"drug_indices_end":[100,125,138]}
{"index":77,"text":"This study was designed to test the hypothesis that positively charged dendrimers form a complex with enoxaparin , a low-molecular weight heparin ( LMWH ) , and that the resulting drug-dendrimer complex is effective in preventing deep vein thrombosis after pulmonary administration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enoxaparin","heparin"],"drug_indices_start":[102,138],"drug_indices_end":[112,145]}
{"index":78,"text":"We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 \u03bcM ) and fast ( 0.25 s \u2265 \u03c4 \u2265 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and \u03b1- and \u03b2-cyclodextrins .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ibuprofen","S-flurbiprofen","salicylic acid","phenylbutazone","\u03b2-cyclodextrins"],"drug_indices_start":[227,239,256,275,303],"drug_indices_end":[236,253,270,289,318]}
{"index":79,"text":"We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer , who had a positive second-look laparatomy or recurrent disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","etoposide"],"drug_indices_start":[61,77],"drug_indices_end":[71,86]}
{"index":80,"text":"Esomeprazole , a proton-pump inhibitor ( PPI ) , is the S-isomer of omeprazole .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Esomeprazole","omeprazole"],"drug_indices_start":[0,68],"drug_indices_end":[12,78]}
{"index":81,"text":"This increase in the number of vasopressin and oxytocin containing neurons in the pig hypothalamus is much later in development than has ever been reported so far .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vasopressin","oxytocin"],"drug_indices_start":[31,47],"drug_indices_end":[42,55]}
{"index":82,"text":"Combinations of alkylating agents and fludarabine or cladribine are also synergistic in producing significantly enhanced activity against refractory lymphoid malignancies , but at the cost of increased haematological toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alkylating agents","fludarabine","cladribine"],"drug_indices_start":[16,38,53],"drug_indices_end":[33,49,63]}
{"index":83,"text":"The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml\/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trazodone","amitriptyline","ethanol","placebo"],"drug_indices_start":[47,70,97,126],"drug_indices_end":[56,83,104,133]}
{"index":84,"text":"A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil\/leucovorin , irinotecan , and bevacizumab therapy for rectal cancer with liver metastases .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil\/leucovorin","irinotecan","bevacizumab"],"drug_indices_start":[75,103,120],"drug_indices_end":[100,113,131]}
{"index":85,"text":"Results of cell viability assays revealed that treatment with a combination of imatinib and chemotherapy agents irinotecan or 5\u2011Fu synergistically inhibited cell growth , compared with treatment with any of these drugs alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["imatinib","irinotecan","5\u2011Fu"],"drug_indices_start":[79,112,126],"drug_indices_end":[87,122,130]}
{"index":86,"text":"We concluded that ifosfamide is an active agent even in patients with tumours resistant to cyclophosphamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","cyclophosphamide"],"drug_indices_start":[18,91],"drug_indices_end":[28,107]}
{"index":87,"text":"The combination of a fluoropyrimidine ( 5-fluorouracil or capecitabine ) with either oxaliplatin or irinotecan has been widely accepted as standard cytotoxic chemotherapy for either the first- or second-line treatment of mCRC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluoropyrimidine","oxaliplatin","irinotecan"],"drug_indices_start":[21,85,100],"drug_indices_end":[37,96,110]}
{"index":88,"text":"In 1517 poor prognosis patients , 21 regimens were used , the commonest being CAV , EV ( etoposide , vincristine ) , CbE , CAV alternating with PE , and oral etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","vincristine","etoposide"],"drug_indices_start":[89,101,158],"drug_indices_end":[98,112,167]}
{"index":89,"text":"Utilizing this data , we suggest that nivolumab plus ipilimumab and cabozantinib may be favored for first-line treatment of specific populations of older patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","ipilimumab","cabozantinib"],"drug_indices_start":[38,53,68],"drug_indices_end":[47,63,80]}
{"index":90,"text":"The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilmicin for empiric treatment of febrile episodes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["piperacillin","netilmicin"],"drug_indices_start":[141,159],"drug_indices_end":[153,169]}
{"index":91,"text":"Thirty-five percent ( 6 of 17 ) of the patients receiving docetaxel alone and 53 % ( 19 of 36 ) of those receiving docetaxel and thalidomide have had a PSA decrease of at least 50 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","docetaxel","thalidomide"],"drug_indices_start":[58,115,129],"drug_indices_end":[67,124,140]}
{"index":92,"text":"Evidence-based guidelines recommend nicotine replacement therapy , bupropion SR , and varenicline as effective alternatives for smoking cessation therapy , especially when combined with behavioral interventions .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotine","bupropion","varenicline"],"drug_indices_start":[36,67,86],"drug_indices_end":[44,76,97]}
{"index":94,"text":"Owing to the wide spread activation of this pathway in numerous neoplasms , trametinib and cobimetinib are being studied in combination with other targeted and cytotoxic drugs in a variety of clinical situations .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trametinib","cobimetinib"],"drug_indices_start":[76,91],"drug_indices_end":[86,102]}
{"index":95,"text":"All these isolates were found to survive in presence of heavy metals like cadmium , lead and zinc and were resistant to antibiotics like ampicillin , tetracycline , streptomycin , penicillin and chloramphenicol as indicated by their Minimum Inhibitory Concentrations ( MIC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","tetracycline","streptomycin","chloramphenicol"],"drug_indices_start":[137,150,165,195],"drug_indices_end":[147,162,177,210]}
{"index":96,"text":"Reduction of ASS1 expression by siRNA significantly sensitized mesothelioma spheroids to the pro-apoptotic effects of bortezomib and of cisplatin plus pemetrexed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","pemetrexed","cisplatin"],"drug_indices_start":[118,136,151],"drug_indices_end":[128,145,161]}
{"index":97,"text":"In conclusion , the combination of thalidomide and cyclosporine in subtherapeutic doses may be useful for the treatment of skin allografts .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["thalidomide","cyclosporine"],"drug_indices_start":[35,51],"drug_indices_end":[46,63]}
{"index":98,"text":"We now wish to report that , under these conditions , the pss-8 mutant is hypersensitive to certain antibiotics , especially to streptomycin , kanamycin , and gentamicin , although also to ampicillin and novobiocin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["streptomycin","kanamycin","gentamicin","ampicillin","novobiocin"],"drug_indices_start":[128,143,159,189,204],"drug_indices_end":[140,152,169,199,214]}
{"index":100,"text":"Rats were subchronically primed with nicotine , clozapine or saline .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotine","clozapine","saline"],"drug_indices_start":[37,48,61],"drug_indices_end":[45,57,67]}
{"index":102,"text":"New agents , such as taxane , irinotecan and oxaliplatin , combined with old agents , such as cisplatin and 5-FU , are currently under evaluation to further improve treatment outcomes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","oxaliplatin","taxane","cisplatin","5-FU"],"drug_indices_start":[21,30,45,94,108],"drug_indices_end":[27,40,56,103,112]}
{"index":103,"text":"Taxinol , Gemcitabine ( GEM ) , Navelbine ( NVB ) , Edatrexate ( ETX ) , CPT-11 and high dose Epirubicin ( EPI HD ) are recommended as new effective drugs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Gemcitabine","Epirubicin"],"drug_indices_start":[10,94],"drug_indices_end":[21,104]}
{"index":104,"text":"One group was given enalapril ( EN ) 50 mg\/l dissolved in the drinking water ; the second received lovastatin ( L ) 15 mg\/kg given daily by gavage ; the third received both agents ; the fourth was left untreated , and the final group received no puromycin and served as the control group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enalapril","lovastatin","puromycin"],"drug_indices_start":[20,99,246],"drug_indices_end":[29,109,255]}
{"index":106,"text":"Combination therapy with mitomycin , tamoxifen , and UFT proved to be an effective postoperative chemoendocrine therapy for stage II , ER-positive breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitomycin","tamoxifen","UFT"],"drug_indices_start":[25,37,53],"drug_indices_end":[34,46,56]}
{"index":107,"text":"The remaining 76 patients did not receive anti-thymocyte globulin but were given cyclosporine A and methotrexate or mycophenolate mofetil ( group 3 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine","methotrexate","mycophenolate"],"drug_indices_start":[81,100,116],"drug_indices_end":[93,112,129]}
{"index":109,"text":"The patient received chemotherapy comprising vincristine , actinomycin D , doxorubicin , cisplatin , and cyclophosphamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","doxorubicin","cyclophosphamide","actinomycin","cisplatin"],"drug_indices_start":[45,59,75,89,105],"drug_indices_end":[56,70,86,98,121]}
{"index":110,"text":"It was found that the increase in acoustic startle responses observed with ethanol or nicotine was attenuated by haloperidol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotine","haloperidol"],"drug_indices_start":[86,113],"drug_indices_end":[94,124]}
{"index":111,"text":"The use of tacrolimus ( 88 % vs 77 % , P=.02 ) and cytolytic therapy ( 81 % vs 46 % , P < .0001 ) was likewise greater among patients who received ganciclovir prophylaxis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tacrolimus","ganciclovir"],"drug_indices_start":[11,147],"drug_indices_end":[21,158]}
{"index":112,"text":"Because gemcitabine has been considered a standard treatment for advanced pancreatic cancer for the past decade , several randomized trials have tested the combination of gemcitabine plus a second agent , including platinum based agents , topoisomerase inhibitors , taxanes , bevacizumab and cetuximab , as biologically \" targeted \" agents .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","gemcitabine","bevacizumab","cetuximab"],"drug_indices_start":[8,171,276,292],"drug_indices_end":[19,182,287,301]}
{"index":113,"text":"Gemcitabine and recently FOLFIRINOX ( 5-flourouracil , leucovorin , oxaliplatin and irinotecan ) have provided some limited survival advantage in advanced pancreatic cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Gemcitabine","leucovorin","oxaliplatin","irinotecan"],"drug_indices_start":[0,55,68,84],"drug_indices_end":[11,65,79,94]}
{"index":114,"text":"No synergism was found against Pneumococci and Meningococci but also no antagonism of the lower MIC and MBC values seen with ampicillin and penicillin G. The combination of chloramphenicol with either penicillin or ampicillin constitutes a clinically successful therapeutic regimen which is now also proven by in vitro investigations .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","chloramphenicol","ampicillin","penicillin","penicillin"],"drug_indices_start":[125,140,173,201,215],"drug_indices_end":[135,150,188,211,225]}
{"index":115,"text":"Similarly , nifedipine , nitroglycerin and hydralazine should not to be considered first-line therapies in the management of hypertensive crises because these agents are associated with significant toxicities and\/or adverse effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nifedipine","hydralazine"],"drug_indices_start":[12,43],"drug_indices_end":[22,54]}
{"index":116,"text":"Bendamustine is effective both with rituximab and as a monotherapy in rituximab-refractory patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bendamustine","rituximab"],"drug_indices_start":[0,36],"drug_indices_end":[12,45]}
{"index":117,"text":"Ten micromoles of gefitinib reversed topotecan , SN-38 , and mitoxantrone resistance , and increased the intracellular topotecan accumulation in the resistant cells but not in the parental cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","topotecan","SN-38","mitoxantrone","topotecan"],"drug_indices_start":[18,37,49,61,119],"drug_indices_end":[27,46,54,73,128]}
{"index":118,"text":"The effects of multiple combination chemotherapy with vincristine , cyclophosphamide ( Endoxan ) , methotrexate , 5-fluorouracil , adriamycin and prednisolone ( VEMFAH ) for advanced breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","cyclophosphamide","methotrexate","5-fluorouracil","adriamycin","prednisolone"],"drug_indices_start":[54,68,99,114,131,146],"drug_indices_end":[65,84,111,128,141,158]}
{"index":119,"text":"Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","mitoxantrone","prednisone","docetaxel"],"drug_indices_start":[76,106,124,141],"drug_indices_end":[85,118,134,150]}
{"index":120,"text":"CDM mice show decreased Homer1a and Homer1b\/c mRNA expression in cortex and blood samples , while chronic treatment with imipramine and fluoxetine or acute ketamine application increases their level only in the cortex .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["imipramine","fluoxetine"],"drug_indices_start":[121,136],"drug_indices_end":[131,146]}
{"index":122,"text":"In addition , stimulation of erythropoiesis with recombinant human erythropoietin , supplemental iron therapy , and improving haemostasis by aprotinin may further reduce homologous blood requirements .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erythropoietin","iron","aprotinin"],"drug_indices_start":[67,97,141],"drug_indices_end":[81,101,150]}
{"index":123,"text":"In the presence of heparin and cortisone and of cortisone alone there was a 4.5- and 2.3-fold reduction , respectively , in the growth of the 9L glioma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["heparin","cortisone","cortisone"],"drug_indices_start":[19,31,48],"drug_indices_end":[26,40,57]}
{"index":124,"text":"Dibutyryl cAMP , forskolin and theophylline stimulated secretion of pancreastatin and somatostatin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["theophylline","somatostatin"],"drug_indices_start":[31,86],"drug_indices_end":[43,98]}
{"index":125,"text":"It was the aim of this study to evaluate maintenance therapy with bevacizumab + capecitabine following induction with bevacizumab + capecitabine + oxaliplatin ( XELOX ) versus bevacizumab + XELOX until progression as first-line therapy in metastatic colorectal cancer ( mCRC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","capecitabine","bevacizumab","capecitabine","oxaliplatin","bevacizumab"],"drug_indices_start":[66,80,118,132,147,176],"drug_indices_end":[77,92,129,144,158,187]}
{"index":126,"text":"We chose to assess the chemopreventive effect of three different drugs : pioglitazone , lanreotide and S-trans-trans-farnesylthiosalicylic acid ( FTS ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pioglitazone","lanreotide","S-trans-trans-farnesylthiosalicylic"],"drug_indices_start":[73,88,103],"drug_indices_end":[85,98,138]}
{"index":127,"text":"Etoposide ( 25 mg , twice daily ) and prednisone ( 5 mg , twice daily ) were administered orally .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Etoposide","prednisone"],"drug_indices_start":[0,38],"drug_indices_end":[9,48]}
{"index":128,"text":"Rosuvastatin + ezetimibe , simvastatin + ezetimibe , and atorvastatin + ezetimibe were the most cost-effective combination therapies for reducing LDL-C levels .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Rosuvastatin","ezetimibe","simvastatin","ezetimibe","atorvastatin","ezetimibe"],"drug_indices_start":[0,15,27,41,57,72],"drug_indices_end":[12,24,38,50,69,81]}
{"index":130,"text":"Nithiamide and chlortetracycline + sulfamethazine + penicillin were least effective in preventing SD during the infection + medication and postmedication periods .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chlortetracycline","sulfamethazine","penicillin"],"drug_indices_start":[15,35,52],"drug_indices_end":[32,49,62]}
{"index":131,"text":"The largest number of strains was resistant to gentamicin , followed by erythromycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gentamicin","erythromycin"],"drug_indices_start":[47,72],"drug_indices_end":[57,84]}
{"index":132,"text":"Behavioural impact of intraseptally released vasopressin and oxytocin in rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vasopressin","oxytocin"],"drug_indices_start":[45,61],"drug_indices_end":[56,69]}
{"index":133,"text":"Optimized 14 day sequential therapy was non-inferior to , but better tolerated than 10 day bismuth quadruple therapy and both may be used in first-line treatment in populations with low to intermediate clarithromycin resistance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bismuth","clarithromycin"],"drug_indices_start":[91,202],"drug_indices_end":[98,216]}
{"index":134,"text":"Initial treatment with either neoadjuvant chemoradiation ( CRT ) or induction FOLFOX ( 5-Fluorouracil , leucovorin , and oxaliplatin ) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-Fluorouracil","leucovorin","oxaliplatin"],"drug_indices_start":[87,104,121],"drug_indices_end":[101,114,132]}
{"index":135,"text":"Prior to the procedure , the child was administered a dental cocktail containing chloral hydrate , hydroxyzine , and methadone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloral hydrate","hydroxyzine","methadone"],"drug_indices_start":[81,99,117],"drug_indices_end":[96,110,126]}
{"index":136,"text":"We aimed to compare the effect of four TK inhibitors ( axitinib , sunitinib , vandetanib , and XL184 ) on cell proliferation , RET expression and autophosphorylation , and ERK activation in cell lines expressing a MEN2A ( MTC-TT ) , a MEN2B ( MZ-CRC-1 ) mutation , and a RET\/PTC ( TPC-1 ) rearrangement .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["axitinib","sunitinib","vandetanib"],"drug_indices_start":[55,66,78],"drug_indices_end":[63,75,88]}
{"index":137,"text":"Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fenofibrate","atorvastatin"],"drug_indices_start":[31,57],"drug_indices_end":[42,69]}
{"index":138,"text":"S. sciuri exhibited pronounced multiresistance , and many isolates were characterised by the carriage of a number of uncommon (multi)resistance genes ( e.g. cfr , apmA , fexA ) and decreased susceptibility towards last resort antibiotics such as linezolid and daptomycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["linezolid","daptomycin"],"drug_indices_start":[246,260],"drug_indices_end":[255,270]}
{"index":139,"text":"The results showed that chlorhexidine ( 0.5 mM ) was more effective than benzalkonium chloride ( 1 mM ) and piperazine ( 1 mM ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chlorhexidine","benzalkonium","piperazine"],"drug_indices_start":[24,73,108],"drug_indices_end":[37,85,118]}
{"index":140,"text":"Finally , although anidulafungin ( as an echinocandin surrogate susceptibility marker ) and amphotericin B ECVs should identify Candida and Aspergillus isolates with reduced susceptibility to these agents using the Etest , these ECVs will not categorize a fungal isolate as susceptible or resistant , as breakpoints do .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anidulafungin","amphotericin"],"drug_indices_start":[19,92],"drug_indices_end":[32,104]}
{"index":141,"text":"The method decision limits were determined to be 1.27 and 0.59 microg\/kg for erythromycin and tylosin , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erythromycin","tylosin"],"drug_indices_start":[77,94],"drug_indices_end":[89,101]}
{"index":142,"text":"Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer ( GERCOR DREAM ; OPTIMOX3 ): a randomised , open-label , phase 3 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","erlotinib"],"drug_indices_start":[0,28],"drug_indices_end":[11,37]}
{"index":143,"text":"Eighteen patients with primary or recurrent ovarian cancer were treated with paclitaxel 150 or 110 mg\/m2 , respectively , together with gemcitabine 800 mg\/m2 and cisplatin 75 mg\/m2 , 3 weekly for 6 cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","gemcitabine"],"drug_indices_start":[77,136],"drug_indices_end":[87,147]}
{"index":144,"text":"After pretreatment with warfarin ( 0.2 mg\/kg\/day ) , low-dose rivaroxaban ( 60 mg\/kg\/day ) , high-dose rivaroxaban ( 120 mg\/kg\/day ) , or vehicle for 14 days , transient middle cerebral artery occlusion was induced for 90 min , followed by reperfusion with tPA ( 10 mg\/kg\/10 ml ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["warfarin","rivaroxaban","rivaroxaban"],"drug_indices_start":[24,62,103],"drug_indices_end":[32,73,114]}
{"index":146,"text":"However , the combination of clindamycin and ciprofloxacin increased mortality associated with B. anthracis Sterne infection , particularly in gamma-irradiated animals .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clindamycin","ciprofloxacin"],"drug_indices_start":[29,45],"drug_indices_end":[40,58]}
{"index":147,"text":"We investigated the maximum tolerated dose , dose-limiting toxicities , and response rate when the selective cyclooxygenase-2 inhibitor celecoxib is added to concurrent irinotecan , cisplatin , and radiation therapy for patients with inoperable stage II-III non-small cell lung cancer ( NSCLC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["celecoxib","irinotecan","cisplatin"],"drug_indices_start":[136,169,182],"drug_indices_end":[145,179,191]}
{"index":148,"text":"The combination of docetaxel and estramustine phosphate ( estramustine ) has been reported to be effective for HRPC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","estramustine","estramustine"],"drug_indices_start":[19,33,58],"drug_indices_end":[28,45,70]}
{"index":149,"text":"Significant advances have been made in the last decade since the introduction of different tyrosine kinase inhibitors ( TKIs ) such as sunitinib , pazopanib , and sorafenib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","pazopanib","sorafenib"],"drug_indices_start":[135,147,163],"drug_indices_end":[144,156,172]}
{"index":150,"text":"A fixed-dose combination of artesunate + amodiaquine ( ASAQ ) was recently developed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artesunate","amodiaquine"],"drug_indices_start":[28,41],"drug_indices_end":[38,52]}
{"index":151,"text":"All patients have received a median of four and half cycles ( range , 1 - 10 ) of 3-week ( 60 - 75 mg\/m2 ) docetaxel regimens and 5 mg prednisone twice per day .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","prednisone"],"drug_indices_start":[107,135],"drug_indices_end":[116,145]}
{"index":152,"text":"Combination therapy with other agents including anticoagulants , antihypertensive , anti-inflammatory , oral hypoglycemic and antifungal agents as well as beta-blockers , H2 blockers , cyclosporine and digoxin has been also reviewed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine","digoxin"],"drug_indices_start":[185,202],"drug_indices_end":[197,209]}
{"index":153,"text":"Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tranexamic","norethisterone"],"drug_indices_start":[21,41],"drug_indices_end":[31,55]}
{"index":154,"text":"The results of this work encourage the in vivo examination of the therapeutic potential of the combination of bortezomib and rapamycin in Mantle Cell Lymphoma patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","rapamycin"],"drug_indices_start":[110,125],"drug_indices_end":[120,134]}
{"index":155,"text":"Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["valsartan","spironolactone"],"drug_indices_start":[29,43],"drug_indices_end":[38,57]}
{"index":156,"text":"54 patients without distant metastases ( T2-T3b , N0-X , M0 ) received 3 cycles of neoadjuvant chemotherapy according to the MVAC protocol ( methotrexate , vinblastine , doxorubicin and cisplatin ) after transurethral resection ( TUR ) followed by cystectomy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","vinblastine","doxorubicin","cisplatin"],"drug_indices_start":[141,156,170,186],"drug_indices_end":[153,167,181,195]}
{"index":157,"text":"The objective of this study was to compare cycle control , efficacy and tolerance of an oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel with a preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ethinylestradiol","desogestrel","ethinylestradiol","gestodene"],"drug_indices_start":[128,160,212,253],"drug_indices_end":[144,171,228,262]}
{"index":158,"text":"They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol\/150 mg desogestrel for two continuous cycle or NSAID ; mefenamic acid 500 mg TDS for 5 days , 21 days apart for two cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ethinyl","desogestrel","mefenamic"],"drug_indices_start":[64,89,137],"drug_indices_end":[71,100,146]}
{"index":159,"text":"Preclinical data suggest that enzastaurin and bevacizumab may have complementary effects in inhibiting angiogenesis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enzastaurin","bevacizumab"],"drug_indices_start":[30,46],"drug_indices_end":[41,57]}
{"index":160,"text":"The PASI-75 , -90 and -100 were the highest in secukinumab ( 91.3 % , 82.6 % , 41.3 % , respectively ) , followed by ustekinumab ( 79.6 % , 44.9 % , 16.3 % ) , adalimumab ( 64.3 % , 28.6 % , 7.1 % ) and etanercept ( 50.0 % , 30.0 % , 0 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["secukinumab","ustekinumab","adalimumab","etanercept"],"drug_indices_start":[47,117,160,203],"drug_indices_end":[58,128,170,213]}
{"index":161,"text":"Trials have demonstrated decreased relapse with perioperative methotrexate , vinblastine , doxorubicin and cisplatin ( M-VAC ) chemotherapy in patients with muscle invasive bladder cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","vinblastine","doxorubicin","cisplatin"],"drug_indices_start":[62,77,91,107],"drug_indices_end":[74,88,102,116]}
{"index":162,"text":"m2 on day 1 , oxaliplatin 85 mg\/m\u00b2 day 1 and capecitabine twice-daily dose of 625 mg\/ m2 , p.o . for 2 weeks ) every 3","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","capecitabine"],"drug_indices_start":[14,45],"drug_indices_end":[25,57]}
{"index":163,"text":"The objective of this analysis was to assess the cost-effectiveness of risedronate compared to generic alendronate in Germany applying the REAL effectiveness data .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["risedronate","alendronate"],"drug_indices_start":[71,103],"drug_indices_end":[82,114]}
{"index":164,"text":"However , two phase III trials demonstrated that incorporation of oxaliplatin to capecitabine with RT did not improve early outcomes and , by contrast , increased toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","capecitabine"],"drug_indices_start":[66,81],"drug_indices_end":[77,93]}
{"index":165,"text":"The addition of everolimus to bicalutamide treatment of resistant tumours significantly reduced tumour growth rates and tumour volumes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["everolimus","bicalutamide"],"drug_indices_start":[16,30],"drug_indices_end":[26,42]}
{"index":166,"text":"Ropivacaine and bupivacaine were the common drugs used for RA , which were independent of RA utilization .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ropivacaine","bupivacaine"],"drug_indices_start":[0,16],"drug_indices_end":[11,27]}
{"index":167,"text":"In 13 patients treated with equivalent doses of rotigotine switched from other DAs ( pramipexole , ropinirole , and cabergoline ) , ESS did not increase after treatment ( 10.0 \u00b1 4.6 before and 8.6 \u00b1 4.5 after treatment ) and decreased without worsening of CGI-I in 54 % patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rotigotine","pramipexole","ropinirole","cabergoline"],"drug_indices_start":[48,85,99,116],"drug_indices_end":[58,96,109,127]}
{"index":168,"text":"To assess plasma steady-state pharmacokinetics ( PK ) of rifampicin , isoniazid , saquinavir and ritonavir in HIV and tuberculosis ( TB ) co-infected patients , and investigate potential interactions between TB drugs and protease inhibitors ( PIs ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["isoniazid","saquinavir","ritonavir","rifampicin"],"drug_indices_start":[57,70,82,97],"drug_indices_end":[67,79,92,106]}
{"index":170,"text":"Toxicological studies revealed that the oral LD50 for thiabendazole in mice was 2200 mg\/kg , and when combined with 140 mg\/kg of aspirin , the LD50 was reduced to 900 mg\/kg .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["thiabendazole","aspirin"],"drug_indices_start":[54,129],"drug_indices_end":[67,136]}
{"index":171,"text":"Azacitidine and enasidenib are two therapies available for treatment of acute myelogenous leukemia ( AML ) , and the mechanisms of action of these drugs involve alteration of aberrant DNA methylation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Azacitidine","enasidenib"],"drug_indices_start":[0,16],"drug_indices_end":[11,26]}
{"index":172,"text":"Good , moderate and mild pain relief were noted in 19 ( 41 % ) , six ( 13 % ) and seven ( 15 % ) patients on lamotrigine and 13 ( 28 % ) , five ( 11 % ) and 15 ( 33 % ) patients on amitriptyline , respectively , by patient 's global assessment of efficacy and safety .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lamotrigine","amitriptyline"],"drug_indices_start":[109,181],"drug_indices_end":[120,194]}
{"index":173,"text":"The majority of the evidence comes from studies of bevacizumab and triamcinolone used as primary therapy for DMO .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","triamcinolone"],"drug_indices_start":[51,67],"drug_indices_end":[62,80]}
{"index":174,"text":"Doxorubicin and ifosfamide are currently the two main drugs for the treatment of soft tissue sarcomas in adults .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Doxorubicin","ifosfamide"],"drug_indices_start":[0,16],"drug_indices_end":[11,26]}
{"index":175,"text":"The skin and oral mucous membrane lesions recurred after effective treatments with methylprednisolone pulse therapy and combination therapy with prednisolone and cyclosporine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methylprednisolone","prednisolone","cyclosporine"],"drug_indices_start":[83,145,162],"drug_indices_end":[101,157,174]}
{"index":176,"text":"Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["colistin","ciprofloxacin"],"drug_indices_start":[17,67],"drug_indices_end":[25,80]}
{"index":178,"text":"Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin 's lymphomas .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["decitabine","vorinostat"],"drug_indices_start":[17,48],"drug_indices_end":[27,58]}
{"index":179,"text":"Epirubicin ( 35 mg\/m(2 ) ) and cyclophosphamide ( 400 mg\/m(2 ) ) were administered from day 2 to day 4 , every 4 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Epirubicin","cyclophosphamide"],"drug_indices_start":[0,31],"drug_indices_end":[10,47]}
{"index":180,"text":"Our patient could be weaned from LVAD probably due to the combination management strategy employing mitral valvuloplasty , use of cardiac resynchronization therapy , and taking carvedilol with spironolactone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carvedilol","spironolactone"],"drug_indices_start":[177,193],"drug_indices_end":[187,207]}
{"index":181,"text":"Serum hydroxyzine and cetirizine concentrations were above the limit of quantitation ( 0.1 ng\/ml ) of the assay","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["hydroxyzine","cetirizine"],"drug_indices_start":[6,22],"drug_indices_end":[17,32]}
{"index":182,"text":"Although well tolerated , the efficacy of everolimus and vinorelbine combination therapy was not superior to vinorelbine monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["everolimus","vinorelbine","vinorelbine"],"drug_indices_start":[42,57,109],"drug_indices_end":[52,68,120]}
{"index":183,"text":"In addition , our results suggested that adalimumab , tocilizumab , rituximab and glucocorticoids may also have beneficial effects in restoring normal transcriptome , but not chloroquine , hydroxychloroquine or interferons .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["adalimumab","tocilizumab","rituximab","chloroquine","hydroxychloroquine"],"drug_indices_start":[41,54,68,175,189],"drug_indices_end":[51,65,77,186,207]}
{"index":184,"text":"In addition , biochemical examinations revealed that docetaxel could induce phosphorylation of both bcl-2 and c-raf-1 , but these changes were inhibited when tumor cells were pretreated or simultaneously treated with doxorubicin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","doxorubicin"],"drug_indices_start":[53,217],"drug_indices_end":[62,228]}
{"index":185,"text":"Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","leucovorin"],"drug_indices_start":[65,92],"drug_indices_end":[77,102]}
{"index":186,"text":"Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","ipilimumab"],"drug_indices_start":[38,68],"drug_indices_end":[47,78]}
{"index":187,"text":"In some relatively developed regions in China , infliximab and rituximab may be a favorable cost-effective alternative for moderate to severe RA .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["infliximab","rituximab"],"drug_indices_start":[48,63],"drug_indices_end":[58,72]}
{"index":188,"text":"Topiramate CR treatment produced significant weight loss and meaningful improvements in A1C and blood pressure in obese patients with type 2 diabetes treated with diet and exercise or in combination with metformin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Topiramate","metformin"],"drug_indices_start":[0,204],"drug_indices_end":[10,213]}
{"index":189,"text":"To compare efficacy and toxicity of bolus application of chemotherapy protocol , oxaliplatin , fluorouracil ( bolus ) , leucovorin ( folfox ) between two groups of patients in the therapy of metastatic colorectal carcinoma ( mCRC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","fluorouracil","leucovorin"],"drug_indices_start":[81,95,120],"drug_indices_end":[92,107,130]}
{"index":190,"text":"Verapamil and quinine were added in patients with tumors failing to respond or progressing on CVAD alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Verapamil","quinine"],"drug_indices_start":[0,14],"drug_indices_end":[9,21]}
{"index":191,"text":"However , dipyridamole had no effect on both the influx and efflux of epirubicin in doxorubicin-sensitive cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dipyridamole","epirubicin"],"drug_indices_start":[10,70],"drug_indices_end":[22,80]}
{"index":192,"text":"This study aims to evaluate the potential role of combination therapy with docetaxel , flavopiridol , or 5-FU in modulating chemosensitivity and better understand how they might be used clinically .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","flavopiridol"],"drug_indices_start":[75,87],"drug_indices_end":[84,99]}
{"index":193,"text":"Dipyridamole or dipyridamole and acetylsalicyclic acid were used in 22 pregnancies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dipyridamole","dipyridamole","acetylsalicyclic acid"],"drug_indices_start":[0,16,33],"drug_indices_end":[12,28,54]}
{"index":194,"text":"Bevacizumab and trastuzumab are efficacious for treatment of advanced or HER2-positive metastatic breast cancer ; however , few data exist for this regimen in inflammatory breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","trastuzumab"],"drug_indices_start":[0,16],"drug_indices_end":[11,27]}
{"index":195,"text":"The frequency of their resistance to penicillin and ampicillin was 76.8 % ( 159\/207 ) , followed by erythromycin ( 56 % , 116\/207 ) , trimethoprim-sulfamethoxazole ( 28.5 % , 59\/207 ) , chloramphenicol ( 24.2 % , 50\/207 ) , kanamycin ( 19.8 % , 41\/207 ) , and doxycycline ( 1.4 % , 3\/207 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","erythromycin","chloramphenicol","kanamycin","doxycycline"],"drug_indices_start":[52,100,186,224,260],"drug_indices_end":[62,112,201,233,271]}
{"index":196,"text":"Rats were distributed into three groups ( n = 5 ) according to the drug studied namely , 50 % enantiomeric excess bupivacaine mixture ( 5 \u03bcg\/mL ) ; pancuronium ( 2 \u03bcg\/mL ) ; 50 % enantiomeric excess bupivacaine mixture + pancuronium .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","pancuronium","bupivacaine","pancuronium"],"drug_indices_start":[114,148,199,221],"drug_indices_end":[125,159,210,232]}
{"index":197,"text":"Blood was sampled immediately prior to premedication ( temazepam ) , after induction of anaesthesia ( fentanyl and thiopentone ) and at 10-minute intervals until the end of the procedure ( N2O maintenance , vecuronium relaxation ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["temazepam","fentanyl","thiopentone","vecuronium"],"drug_indices_start":[55,102,115,207],"drug_indices_end":[64,110,126,217]}
{"index":198,"text":"This study was performed to compare the efficacy of peritonsillar infiltration of bupivacaine , tramadol and combination of bupivacaine-tramadol in post-tonsillectomy pain .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","tramadol"],"drug_indices_start":[82,96],"drug_indices_end":[93,104]}
{"index":199,"text":"The planned concomitant treatment in group B was : bleomycin 5 units twice a week i.m . , total dose 70 units , mitomycin C 15 mg\/m2 i.v . after delivery of 10 Gy , and 10 mg\/m2 i.v . on the last day of radiotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","mitomycin"],"drug_indices_start":[51,112],"drug_indices_end":[60,121]}
{"index":200,"text":"The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dulanermin","FOLFOX6","bevacizumab"],"drug_indices_start":[112,152,164],"drug_indices_end":[122,159,175]}
{"index":201,"text":"Inhalatory beta2-mimetics with long-term action ( LABA ) , formoterol and salmeterol , possess a period of action longer than 12 hours .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["formoterol","salmeterol"],"drug_indices_start":[59,74],"drug_indices_end":[69,84]}
{"index":202,"text":"This study evaluates the possible protective effects of the calcium channel blocker amlodipine , the angiotensin converting enzyme inhibitor lisinopril , and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity , aiming to understand its underlying hepatotoxic mechanisms .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amlodipine","lisinopril","allopurinol"],"drug_indices_start":[84,141,189],"drug_indices_end":[94,151,200]}
{"index":203,"text":"The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","methotrexate","fluorouracil"],"drug_indices_start":[146,165,182],"drug_indices_end":[162,177,194]}
{"index":204,"text":"This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["emedastine","loratadine"],"drug_indices_start":[44,100],"drug_indices_end":[54,110]}
{"index":205,"text":"Erythromycin , clindamycin and carbenicillin suppressed the donor flora permanently , as could be seen by the reduced colonization resistance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Erythromycin","clindamycin","carbenicillin"],"drug_indices_start":[0,15,31],"drug_indices_end":[12,26,44]}
{"index":206,"text":"Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mycophenolate","nivolumab","ipilimumab"],"drug_indices_start":[0,126,141],"drug_indices_end":[13,135,151]}
{"index":207,"text":"The mannose-linked prodrugs of saquinavir and indinavir display therefore a most promising therapeutic potential provided that bioavailability , penetration into the HIV infected macrophages , and HIV-reservoirs of these PIs are improved .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["saquinavir","indinavir"],"drug_indices_start":[31,46],"drug_indices_end":[41,55]}
{"index":208,"text":"Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nevirapine","zidovudine"],"drug_indices_start":[78,134],"drug_indices_end":[88,144]}
{"index":209,"text":"Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg\/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg\/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","bleomycin","etoposide"],"drug_indices_start":[59,117,178],"drug_indices_end":[68,126,187]}
{"index":210,"text":"The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisone","vincristine","cytarabine","L-asparaginase","methotrexate","dexamethasone"],"drug_indices_start":[42,55,69,84,141,156],"drug_indices_end":[52,66,79,98,153,169]}
{"index":211,"text":"Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil","oxaliplatin","irinotecan","leucovorin"],"drug_indices_start":[71,97,111,128],"drug_indices_end":[85,108,121,138]}
{"index":212,"text":"Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and \u03b2-catenin expression by upregulating the E3 ubiquitin ligase \u03b2-TrCP to abolished docetaxel and vinorelbine resistance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","docetaxel","vinorelbine"],"drug_indices_start":[16,193,207],"drug_indices_end":[23,202,218]}
{"index":213,"text":"No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","doxorubicin"],"drug_indices_start":[18,32],"drug_indices_end":[28,43]}
{"index":214,"text":"Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and\/or ifosfamide , carboplatin , and etoposide ( n = 7 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cytarabine","etoposide","ifosfamide","carboplatin","etoposide"],"drug_indices_start":[22,64,79,107,120,138],"drug_indices_end":[31,74,88,117,131,147]}
{"index":215,"text":"A significant reduction in plasma 8-isoprostane and oxLDL levels was observed in all treatment groups [ by 10 % , 8 % and 6 % ( p < 0.05 compared with baseline ) and 41 % , 40 % and 39 % ( p < 0.001 compared with baseline ) in simvastatin , simvastatin\/ezetimibe and rosuvastatin groups , respectively ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["simvastatin","rosuvastatin"],"drug_indices_start":[227,267],"drug_indices_end":[238,279]}
{"index":217,"text":"In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","methotrexate","vinblastine","doxorubicin","cisplatin"],"drug_indices_start":[45,61,167,182,196],"drug_indices_end":[56,70,179,193,207]}
{"index":218,"text":"In the last few years , a flurry of new and more potent ALK inhibitors has emerged for the treatment of ALK-positive NSCLC , including ceritinib ( LDK378 ) , alectinib ( RO5424802\/CH5424802 ) , AP26113 , ASP3026 , TSR-011 , PF-06463922 , RXDX-101 , X-396 , and CEP-37440 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ceritinib","alectinib"],"drug_indices_start":[135,158],"drug_indices_end":[144,167]}
{"index":219,"text":"A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","ifosfamide","cisplatin"],"drug_indices_start":[58,72,89],"drug_indices_end":[69,82,98]}
{"index":220,"text":"Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","leucovorin","5-fluorouracil"],"drug_indices_start":[25,49,77],"drug_indices_end":[35,63,87]}
{"index":221,"text":"Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","cyclophosphamide","mitoxantrone"],"drug_indices_start":[32,46,67],"drug_indices_end":[43,62,79]}
{"index":222,"text":"After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vemurafenib","ipilimumab"],"drug_indices_start":[33,74],"drug_indices_end":[44,84]}
{"index":223,"text":"Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","paclitaxel","bevacizumab","capecitabine"],"drug_indices_start":[0,17,35,52],"drug_indices_end":[11,27,46,64]}
{"index":224,"text":"She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","leucovorin","oxaliplatin"],"drug_indices_start":[56,71,87],"drug_indices_end":[68,81,98]}
{"index":225,"text":"We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel","cetuximab","bevacizumab"],"drug_indices_start":[107,121,134,150],"drug_indices_end":[118,131,143,161]}
{"index":226,"text":"All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mexiletine","propafenone"],"drug_indices_start":[23,59],"drug_indices_end":[33,70]}
{"index":227,"text":"Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg\/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cephalexin","cephalexin","trimethoprim-sulfamethoxazole"],"drug_indices_start":[0,41,141],"drug_indices_end":[10,70,151]}
{"index":228,"text":"In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["neratinib","capecitabine","lapatinib","capecitabine"],"drug_indices_start":[20,35,158,173],"drug_indices_end":[29,47,167,185]}
{"index":229,"text":"Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","cilostazol"],"drug_indices_start":[31,43],"drug_indices_end":[38,53]}
{"index":230,"text":"This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","etanercept"],"drug_indices_start":[96,113],"drug_indices_end":[108,123]}
{"index":233,"text":"Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ranibizumab","dexamethasone"],"drug_indices_start":[39,94],"drug_indices_end":[50,107]}
{"index":234,"text":"Rabeprazole was similar to omeprazole and superior to placebo in both maintenance of healing and prevention of symptoms in patients with healed GERD in 1-year studies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Rabeprazole","omeprazole"],"drug_indices_start":[0,27],"drug_indices_end":[11,37]}
{"index":235,"text":"We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as compared with 6 months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","leucovorin","oxaliplatin","capecitabine","oxaliplatin"],"drug_indices_start":[198,213,230,255,272],"drug_indices_end":[210,223,241,267,283]}
{"index":236,"text":"Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["celecoxib","erlotinib","celecoxib","erlotinib"],"drug_indices_start":[120,134,175,188],"drug_indices_end":[129,143,184,197]}
{"index":237,"text":"Subcutaneous aspirin , 100 mg\/kg , which reduced duodenal PGE2 generation to a greater degree than either ulcerogen , given in conjunction with pentagastrin , did not produce visible duodenal ulceration.(ABSTRACT TRUNCATED AT 250 WORDS )","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","pentagastrin"],"drug_indices_start":[13,144],"drug_indices_end":[20,156]}
{"index":238,"text":"Prevalence of metronidazole , clarithromycin , and amoxicillin resistance is high in developing world including Africa .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metronidazole","clarithromycin","amoxicillin"],"drug_indices_start":[14,30,51],"drug_indices_end":[27,44,62]}
{"index":239,"text":"These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levonorgestrel","ethinyl"],"drug_indices_start":[48,77],"drug_indices_end":[62,84]}
{"index":240,"text":"The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ixabepilone","capecitabine"],"drug_indices_start":[19,35],"drug_indices_end":[30,47]}
{"index":241,"text":"We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","paclitaxel"],"drug_indices_start":[182,198],"drug_indices_end":[193,208]}
{"index":242,"text":"More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[16,32],"drug_indices_end":[26,43]}
{"index":243,"text":"Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mitoxantrone","cyclophosphamide"],"drug_indices_start":[0,17],"drug_indices_end":[12,33]}
{"index":245,"text":"It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cimetidine","DPPE","tamoxifen","N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl"],"drug_indices_start":[45,79,134,145],"drug_indices_end":[55,131,138,154]}
{"index":246,"text":"We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","oxaliplatin"],"drug_indices_start":[180,197],"drug_indices_end":[192,208]}
{"index":247,"text":"From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","ifosfamide","dactinomycin","etoposide"],"drug_indices_start":[63,79,95,111],"drug_indices_end":[74,89,107,120]}
{"index":248,"text":"This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amlodipine","atorvastatin"],"drug_indices_start":[80,95],"drug_indices_end":[90,107]}
{"index":250,"text":"He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chlorambucil","procarbazine","prednisone"],"drug_indices_start":[60,98,115],"drug_indices_end":[72,110,125]}
{"index":251,"text":"The introduction of rituximab , alemtuzumab , and bendamustine has improved the current outlook for patients with CLL .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","alemtuzumab","bendamustine"],"drug_indices_start":[20,32,50],"drug_indices_end":[29,43,62]}
{"index":252,"text":"Ten patients were treated with pirfenidone ( 2403 mg\/die ) and 1 with nintedanib","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pirfenidone","nintedanib"],"drug_indices_start":[31,70],"drug_indices_end":[42,80]}
{"index":254,"text":"Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","rituximab"],"drug_indices_start":[10,25],"drug_indices_end":[20,34]}
{"index":255,"text":"The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","carboplatin","etoposide"],"drug_indices_start":[4,17,33],"drug_indices_end":[14,28,42]}
{"index":256,"text":"Tofacitinib combination therapy was also associated with the lower PMPM cost compared with adalimumab combination therapy in the TNF-IR analysis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Tofacitinib","adalimumab"],"drug_indices_start":[0,91],"drug_indices_end":[11,101]}
{"index":257,"text":"Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alendronate","parathyroid hormone","raloxifene"],"drug_indices_start":[37,51,86],"drug_indices_end":[48,70,96]}
{"index":258,"text":"Atorvastatin and metformin both have pleiotropic effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Atorvastatin","metformin"],"drug_indices_start":[0,17],"drug_indices_end":[12,26]}
{"index":259,"text":"Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","irinotecan","oxaliplatin"],"drug_indices_start":[0,172,187],"drug_indices_end":[11,182,198]}
{"index":260,"text":"Available data indicate that GLY and aclidinium have similar efficacy to tiotropium in terms of improving lung function , dyspnea , exacerbations , and health status .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["GLY","aclidinium","tiotropium"],"drug_indices_start":[29,37,73],"drug_indices_end":[32,47,83]}
{"index":261,"text":"Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pembrolizumab","axitinib","sunitinib"],"drug_indices_start":[91,110,132],"drug_indices_end":[104,118,141]}
{"index":262,"text":"Patients received 175 mg\/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg\/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","nedaplatin"],"drug_indices_start":[30,75],"drug_indices_end":[40,85]}
{"index":264,"text":"[ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dofetilide","verapamil"],"drug_indices_start":[29,44],"drug_indices_end":[39,53]}
{"index":265,"text":"Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg\/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg\/m(2 ) i.v , on day 1 ) , every 3 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","docetaxel"],"drug_indices_start":[110,177],"drug_indices_end":[122,186]}
{"index":266,"text":"Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epirubicin","cyclophosphamide"],"drug_indices_start":[97,112],"drug_indices_end":[107,128]}
{"index":267,"text":"The hearts were treated during the whole procedure either with vehicle , 0.5 \u03bcM flecainide ( sodium channel blocker ) or 100 \u03bcM streptomycin ( here used as stretch-activated ion-channel blocker ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["flecainide","streptomycin"],"drug_indices_start":[80,128],"drug_indices_end":[90,140]}
{"index":268,"text":"In the APHINITY study ( NCT01358877 , BIG 4 - 11\/BO25126\/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertuzumab","trastuzumab"],"drug_indices_start":[71,91],"drug_indices_end":[81,102]}
{"index":269,"text":"In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["panitumumab","cetuximab","bevacizumab"],"drug_indices_start":[40,55,105],"drug_indices_end":[51,64,116]}
{"index":270,"text":"The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["adapalene","minocycline"],"drug_indices_start":[50,148],"drug_indices_end":[59,159]}
{"index":271,"text":"Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","methotrexate","5-FU","prednisone","doxorubicin"],"drug_indices_start":[23,42,57,64,81],"drug_indices_end":[39,54,61,74,92]}
{"index":273,"text":"Individual studies have reported differences between antiandrogens in terms of both tolerability and efficacy-for example , bicalutamide has been shown to be better tolerated than flutamide , and may be associated with improved survival .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bicalutamide","flutamide"],"drug_indices_start":[124,180],"drug_indices_end":[136,189]}
{"index":274,"text":"A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Montelukast","Levocetirizine"],"drug_indices_start":[145,161],"drug_indices_end":[156,175]}
{"index":275,"text":"Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefoperazone","sulbactam"],"drug_indices_start":[30,47],"drug_indices_end":[42,56]}
{"index":276,"text":"HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","carmustine","thiotepa"],"drug_indices_start":[9,28,43],"drug_indices_end":[25,38,51]}
{"index":277,"text":"Melatonin or sulpiride could replace these environmental factors .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Melatonin","sulpiride"],"drug_indices_start":[0,13],"drug_indices_end":[9,22]}
{"index":278,"text":"Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked Glycan of the mAbs Produced in a Plant with Fucosyltransferase and Xylosyltransferase Gene Knockouts .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Trastuzumab","Pertuzumab"],"drug_indices_start":[0,16],"drug_indices_end":[11,26]}
{"index":279,"text":"A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","vinorelbine","vinorelbine"],"drug_indices_start":[57,74,214],"drug_indices_end":[68,85,225]}
{"index":280,"text":"Men with prostate cancer were randomly assigned to one of four treatment arms : leuprorelin , goserelin , cyproterone acetate ( CPA ) , or close clinical monitoring .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["leuprorelin","goserelin","cyproterone"],"drug_indices_start":[80,94,106],"drug_indices_end":[91,103,117]}
{"index":281,"text":"There were no significant differences between the two treatment groups , except that amantadine was inferior to mycophenolate mofetil regarding the outcome failure to achieve end-of treatment virological response ( low quality of evidence ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amantadine","mycophenolate"],"drug_indices_start":[85,112],"drug_indices_end":[95,125]}
{"index":282,"text":"Furthermore , more incidences of severe fatigue , thrombocytopenia , and neutropenia were recorded for sunitinib , but pazopanib had more liver toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","pazopanib"],"drug_indices_start":[103,119],"drug_indices_end":[112,128]}
{"index":283,"text":"Streptomycin appears to be the most effective agent followed by gentamicin and the least active was netilmicin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Streptomycin","gentamicin","netilmicin"],"drug_indices_start":[0,64,100],"drug_indices_end":[12,74,110]}
{"index":284,"text":"Neither behavioral therapy , clomipramine , methylphenidate , buspirone , nor naltrexone was effective in monotherapeutic trials .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clomipramine","methylphenidate","buspirone","naltrexone"],"drug_indices_start":[29,44,62,78],"drug_indices_end":[41,59,71,88]}
{"index":285,"text":"Pharmacokinetic PET imaging data analysis quantitatively showed the pharmacological effects of teriparatide-induced suppression of upper gastrointestinal motility and its restoration by granisetron and mosapride .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["granisetron","mosapride"],"drug_indices_start":[186,202],"drug_indices_end":[197,211]}
{"index":286,"text":"Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["palbociclib","ribociclib","letrozole","anastrozole","fulvestrant"],"drug_indices_start":[31,46,86,99,114],"drug_indices_end":[42,56,95,110,125]}
{"index":287,"text":"Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine","lovastatin"],"drug_indices_start":[56,73],"drug_indices_end":[68,83]}
{"index":289,"text":"Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","doxorubicin","docetaxel"],"drug_indices_start":[26,50,66],"drug_indices_end":[37,61,75]}
{"index":290,"text":"A single bolus of dexamethasone , given before a single large meal , produces a delayed ( 6-hour ) but long-lasting increase in serum leptin ( over 16 hours ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexamethasone","leptin"],"drug_indices_start":[18,134],"drug_indices_end":[31,140]}
{"index":291,"text":"The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aripiprazole","valproic","haloperidol","valproic"],"drug_indices_start":[113,143,185,202],"drug_indices_end":[125,151,196,210]}
{"index":292,"text":"Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ketorolac","propofol"],"drug_indices_start":[75,217],"drug_indices_end":[84,225]}
{"index":293,"text":"The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vandetanib","bicalutamide","bicalutamide"],"drug_indices_start":[19,34,129],"drug_indices_end":[29,46,141]}
{"index":294,"text":"Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aspirin","Atenolol","Metformin"],"drug_indices_start":[39,53,65],"drug_indices_end":[46,61,74]}
{"index":295,"text":"Coadministration of vorinostat and oxaliplatin induced G2\/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vorinostat","oxaliplatin"],"drug_indices_start":[20,35],"drug_indices_end":[30,46]}
{"index":296,"text":"Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gentamicin","doxycycline"],"drug_indices_start":[25,40],"drug_indices_end":[35,51]}
{"index":297,"text":"The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","clopidogrel"],"drug_indices_start":[48,60],"drug_indices_end":[55,71]}
{"index":298,"text":"We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg\/d ) and cytarabine ( 200 mg\/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy excluding TKIs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["daunorubicin","imatinib","cytarabine"],"drug_indices_start":[40,85,120],"drug_indices_end":[52,93,130]}
{"index":299,"text":"[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","adriamycin","prednisolone","tamoxifen"],"drug_indices_start":[84,103,116,133],"drug_indices_end":[100,113,128,142]}
{"index":300,"text":"Ra ( rate of production ) was measured during infusion of variable doses of epinephrine with or without variable doses of propranolol , a competitive beta-adrenergic antagonist to isolate the alpha-adrenergic agonist effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epinephrine","propranolol"],"drug_indices_start":[76,122],"drug_indices_end":[87,133]}
{"index":301,"text":"The ranking order of the response rate was LD ( best ) , doxorubicin , epirubicin , ED , and DD ( worst ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","epirubicin"],"drug_indices_start":[57,71],"drug_indices_end":[68,81]}
{"index":302,"text":"Systemic treatment with physostigmine , an inhibitor of acetylcholinesterase , modestly reduced the acquisition and rate of heroin self-administration , and this suppression of heroin intake was reversed by pretreatment with scopolamine but not by mecamylamine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["physostigmine","scopolamine","mecamylamine"],"drug_indices_start":[24,225,248],"drug_indices_end":[37,236,260]}
{"index":303,"text":"First-line lenvatinib , which was shown to be noninferior to sorafenib , excluded patients with main portal trunk invasion .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lenvatinib","sorafenib"],"drug_indices_start":[11,61],"drug_indices_end":[21,70]}
{"index":304,"text":"The OAK study evaluated the efficacy and safety of atezolizumab versus docetaxel as second-line or third-line treatment for stage IIIb\/IV non-small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atezolizumab","docetaxel"],"drug_indices_start":[51,71],"drug_indices_end":[63,80]}
{"index":305,"text":"In conclusion , combined treatment with 0.375 IU of bleomycin and 4 mg of triamcinolone acetonide to 1 cm2 was considered to be an acceptable procedure for the treatment of keloids .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","triamcinolone"],"drug_indices_start":[52,74],"drug_indices_end":[61,87]}
{"index":306,"text":"A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levetiracetam","topiramate","lacosamide","topiramate"],"drug_indices_start":[101,119,145,200],"drug_indices_end":[114,129,155,210]}
{"index":307,"text":"[ A randomized controlled trial of immunochemotherapy using carmofur ( HCFU ) , mitomycin C and immunopotentiators in advanced gastric cancer following noncurative resection and nonresection ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carmofur","mitomycin"],"drug_indices_start":[60,80],"drug_indices_end":[68,89]}
{"index":309,"text":"Blockade of beta-receptors by the nonselective beta-blocking agent propranolol did not modify the brachial artery diameter , whereas pindolol increased this parameter for the same degree of blood pressure reduction .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","pindolol"],"drug_indices_start":[67,133],"drug_indices_end":[78,141]}
{"index":310,"text":"Nab-paclitaxel has demonstrated improved PFS and tolerability compared with standard cremophor-solubilized paclitaxel ; based on this , we examined the efficacy and safety of combining weekly nab-paclitaxel with carboplatin and bevacizumab in TNMBC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Nab-paclitaxel","paclitaxel","carboplatin","bevacizumab","nab-paclitaxel"],"drug_indices_start":[0,107,192,212,228],"drug_indices_end":[14,117,206,223,239]}
{"index":311,"text":"Acute renal failure ( ARF ) occurred concomitantly with the administration of gentamicin in combination with clindamycin in three patients in whom no other known predisposing cause of ARF could be demonstrated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gentamicin","clindamycin"],"drug_indices_start":[78,109],"drug_indices_end":[88,120]}
{"index":312,"text":"However , nicotinic acid , nicotinamide , and pyridoxamine are not able to reverse the effect of isoniazid .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotinamide","isoniazid"],"drug_indices_start":[27,97],"drug_indices_end":[39,106]}
{"index":313,"text":"To explore the role of augmenting neutrophil function in B-cell lymphoma , we conducted a phase II study evaluating the safety and clinical efficacy of pegfilgrastim and rituximab in low-grade CD20","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pegfilgrastim","rituximab"],"drug_indices_start":[152,170],"drug_indices_end":[165,179]}
{"index":314,"text":"The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept ( sequential treatment group ) in patients with diabetic macular edema ( DME ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aflibercept","dexamethasone","aflibercept"],"drug_indices_start":[50,69,103],"drug_indices_end":[61,82,114]}
{"index":315,"text":"Patients with advanced solid tumors received standard doses of paclitaxel and carboplatin on day 1 followed by either 0.1 mg\/Kg or 0.2 mg\/Kg CP-870,893 on day 3 ( Schedule A ) or day 8 ( Schedule B ) , repeated every 21 d.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","CP-870,893"],"drug_indices_start":[63,78,141],"drug_indices_end":[73,89,151]}
{"index":316,"text":"Thirty-two patients with advanced breast carcinoma were randomized to receive increasing doses of paclitaxel ( 45 , 65 , 80 , 90 and 100 mg\/m2 ) or docetaxel ( 30 , 35 , 40 , 45 and 50 mg\/m2 ) together with the CMF agents at the same dose as that used in the conventional regimen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","docetaxel"],"drug_indices_start":[98,148],"drug_indices_end":[108,157]}
{"index":317,"text":"In a 52-week , open-label , multicenter , extension study , HDL-C , TG , and LDL-C levels continued to improve , or were maintained , during combination therapy with once-daily fenofibric acid 135 mg plus a moderate-dose statin ( atorvastatin 40 mg , rosuvastatin 20 mg , or simvastatin 40 mg ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fenofibric","atorvastatin","rosuvastatin","simvastatin"],"drug_indices_start":[177,230,251,275],"drug_indices_end":[187,242,263,286]}
{"index":318,"text":"To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lamivudine","zidovudine","zidovudine"],"drug_indices_start":[49,86,112],"drug_indices_end":[59,96,122]}
{"index":319,"text":"Bradykinin enhanced the effect of carbachol by about 10 - 15 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bradykinin","carbachol"],"drug_indices_start":[0,34],"drug_indices_end":[10,43]}
{"index":320,"text":"Here , we report that combinatorial treatment using EGFRis , such as gefitinib or erlotinib , with PI3K\/AKT pathway inhibitors ( PI3K\/AKTis ) demonstrated a synergistic , anti-proliferative effect in cell lines of the basal-like ( BL ) subtype , a subtype of TNBC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","erlotinib","PI3K\/AKTis"],"drug_indices_start":[69,82,129],"drug_indices_end":[78,91,139]}
{"index":321,"text":"Patients received gemcitabine 1000 mg\/m\u00b2 intravenously on days 1 and 8 , capecitabine 1300 mg\/m\u00b2 oral daily from day 1 to 14 , and dovitinib oral daily 5 days on and 2 days off , every 21-day cycle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","capecitabine","dovitinib"],"drug_indices_start":[18,73,131],"drug_indices_end":[29,85,140]}
{"index":322,"text":"A reduced dose of oxaliplatin 105 mg\/m(2 ) on day 1 with doxorubicin at 20 mg\/m(2)\/dose on days 1 - 3 was well tolerated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","doxorubicin"],"drug_indices_start":[18,57],"drug_indices_end":[29,68]}
{"index":323,"text":"In terms of recurrent disease , two positive phase III trials revealed that trebananib and cediranib are effective anti-angiogenic agents for this indication .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trebananib","cediranib"],"drug_indices_start":[76,91],"drug_indices_end":[86,100]}
{"index":324,"text":"A total of 80 patients were randomized , including 44 to the combination group ( tamsulosin 0.4 mg and tolterodine early release 4 mg ) and 36 to the monotherapy group ( tamsulosin 0.4 mg and placebo ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamsulosin","tolterodine","tamsulosin"],"drug_indices_start":[81,103,170],"drug_indices_end":[91,114,180]}
{"index":325,"text":"However , thiostrepton , dexamethasone , 2-methoxyestradiol , \u03b4-tocotrienol , quercetin , and quinine sulphate were effective in pancreatic , prostate , breast , lungs , melanoma , \u0392-lymphocytes , and T-cells ( Jurkat : 40 % to 95 % ) compared to respective controls .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexamethasone","quinine"],"drug_indices_start":[25,94],"drug_indices_end":[38,101]}
{"index":326,"text":"Of them , 47 patients started with docetaxel at cycle one due to reaction to paclitaxel ( n=32 ) , fear of NT ( n=4 ) , and other reasons ( n=11 ) , whereas 59 patients switched to docetaxel during cycle 2 - 6 due to NT ( n=32 ) , reaction to paclitaxel ( n=19 ) , and other reasons ( n=8 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","paclitaxel","docetaxel","paclitaxel"],"drug_indices_start":[35,77,181,243],"drug_indices_end":[44,87,190,253]}
{"index":327,"text":"Treatment of rapidly progressive glomerulonephritis by extracorporeal immunoadsorption , prednisolone and cyclophosphamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisolone","cyclophosphamide"],"drug_indices_start":[89,106],"drug_indices_end":[101,122]}
{"index":328,"text":"[ Doxifluridine , medroxyprogesterone acetate and cyclophosphamide ( DMpC ) combination therapy is effective against recurrent triple negative breast cancer -- a case report ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Doxifluridine","medroxyprogesterone","cyclophosphamide"],"drug_indices_start":[2,18,50],"drug_indices_end":[15,37,66]}
{"index":329,"text":"Superposition predicted that oral dosing of 1800-mg valganciclovir two times daily would fail to produce and maintain effective plasma concentrations of ganciclovir .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["valganciclovir","ganciclovir"],"drug_indices_start":[52,153],"drug_indices_end":[66,164]}
{"index":331,"text":"The clonidine DV suppression was reliably reversed by yohimbine ( 1.75 micrograms ) , but by none of the other adrenoceptor antagonists or naloxone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonidine","yohimbine","naloxone"],"drug_indices_start":[4,54,139],"drug_indices_end":[13,63,147]}
{"index":332,"text":"There was heterogeneity in tumour responsiveness to sunitinib or sorafenib according to CAIX status ; the mean shrinkage was -17 % vs -25 % for sunitinib-treated patients with high vs low tumour CAIX expression , compared to -13 % vs + 9 % for sorafenib-treated patients ( P interaction , 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","sorafenib"],"drug_indices_start":[52,65],"drug_indices_end":[61,74]}
{"index":333,"text":"Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Seribantumab","Erlotinib"],"drug_indices_start":[29,62],"drug_indices_end":[41,71]}
{"index":334,"text":"Trabectedin in combination with pegylated liposomal doxorubicin ( PLD ) has been fully available privately in the UK since 2009 for treating patients with ROC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Trabectedin","doxorubicin"],"drug_indices_start":[0,52],"drug_indices_end":[11,63]}
{"index":335,"text":"More interestingly , lumefantrine tolerance is associated with an increase in chloroquine susceptibility , raising the possibility of re-introducing chloroquine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lumefantrine","chloroquine","chloroquine"],"drug_indices_start":[21,78,149],"drug_indices_end":[33,89,160]}
{"index":336,"text":"Estramustine has been shown to potentiate the antimicrotubule effects of vinblastine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Estramustine","vinblastine"],"drug_indices_start":[0,73],"drug_indices_end":[12,84]}
{"index":337,"text":"Cohort 7 ( gemcitabine 600 mg\/m\/wk and carboplatin 2 AUC ) showed 4 dose limiting toxicities : 2 grade 3 esophagitis ; one grade 3 febrile neutropenia ; and one grade 4 neutropenia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","carboplatin"],"drug_indices_start":[11,39],"drug_indices_end":[22,50]}
{"index":338,"text":"Treatment with IFN-\u03b1 plus bevacizumab or standard targeted therapy ( sunitinib ) may lead to similar one-year overall mortality ( RR 0.37 , 95 % CI 0.13 to 1.08 ; 1 study ; 83 participants ; low-quality evidence ) and AEs of grade 3 or greater ( RR 1.18 , 95 % CI 0.85 to 1.62 ; 1 study ; 82 participants ; low-quality evidence ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","sunitinib","IFN-\u03b1"],"drug_indices_start":[15,26,69],"drug_indices_end":[20,37,78]}
{"index":339,"text":"In vitro , ETV4 depletion inhibited cell survival but did not influence sensitivity to MEKi selumetinib or trametinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["selumetinib","trametinib"],"drug_indices_start":[92,107],"drug_indices_end":[103,117]}
{"index":340,"text":"Our study aimed to analyze the influence of sorafenib and sunitinib on the frequency of Treg in patients with metastatic RCC ( mRCC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","sunitinib"],"drug_indices_start":[44,58],"drug_indices_end":[53,67]}
{"index":341,"text":"Naloxone ( 5 x 10(-7 ) mol\/kg iv ) and atropine ( 0.1 mg\/kg iv ) induced isolated orad contractions .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Naloxone","atropine"],"drug_indices_start":[0,39],"drug_indices_end":[8,47]}
{"index":342,"text":"FACT-P change from baseline over time was better for abiraterone than for enzalutamide in the \u226575-yr model ( p=0.003 ) , with no difference in the < 75-yr model ( p>0.9 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["abiraterone","enzalutamide"],"drug_indices_start":[53,74],"drug_indices_end":[64,86]}
{"index":343,"text":"The possibility that verapamil might increase the sensibility of colorectal carcinomas to doxorubicin was studied in 24 patients without previous cytotoxic chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","doxorubicin"],"drug_indices_start":[21,90],"drug_indices_end":[30,101]}
{"index":344,"text":"Twenty-six patients presenting with advanced breast cancer with a taxane- and vinorelbine-free line of chemotherapy were included and treated with vinorelbine ( 20 mg\/m2 on D1 , D15 ) , followed by paclitaxel ( 175 mg\/m2 on D1 ) , every 3 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinorelbine","paclitaxel"],"drug_indices_start":[147,198],"drug_indices_end":[158,208]}
{"index":345,"text":"Although monotherapy with cytotoxic agents , including docetaxel and pemetrexed , is recommended for patients with previously treated advanced non-small cell lung cancer ( NSCLC ) , its outcomes are unsatisfactory .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","pemetrexed"],"drug_indices_start":[55,69],"drug_indices_end":[64,79]}
{"index":346,"text":"Although congestive heart failure has been reported with the combination of a beta blocker and either verapamil or nifedipine , it has not previously been reported for combination therapy that includes diltiazem .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","nifedipine","diltiazem"],"drug_indices_start":[102,115,202],"drug_indices_end":[111,125,211]}
{"index":347,"text":"Relationships between heart rate , exercise tolerance and cardiac output in atrial fibrillation : the effects of treatment with digoxin , verapamil and diltiazem .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["digoxin","verapamil","diltiazem"],"drug_indices_start":[128,138,152],"drug_indices_end":[135,147,161]}
{"index":348,"text":"Oxaliplatin , which is effective for colorectal cancer ( CRC ) in combination with 5-fluorouracil ( 5-FU ) and leucovorin ( LV ) , is widely used for metastatic CRC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Oxaliplatin","leucovorin","5-fluorouracil"],"drug_indices_start":[0,83,111],"drug_indices_end":[11,97,121]}
{"index":349,"text":"The cytotoxicity of sequential combinations of a taxoid [ paclitaxel ( TAX ) or docetaxel ( TXT ) ] with a vinca alkaloid [ vinorelbine ( NVB ) ] was compared in differentiated and undifferentiated HT29-D4 cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","docetaxel","vinorelbine"],"drug_indices_start":[58,80,124],"drug_indices_end":[68,89,135]}
{"index":350,"text":"Time to first deterioration was delayed with nivolumab + ipilimumab versus chemotherapy across LCSS and EQ-5D summary measures .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","ipilimumab"],"drug_indices_start":[45,57],"drug_indices_end":[54,67]}
{"index":351,"text":"In the present study , we investigated the effect atorvastatin , celecoxib and tipifarnib in combination on proliferation and apoptosis in Panc-1 sphere-forming cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atorvastatin","celecoxib","tipifarnib"],"drug_indices_start":[50,65,79],"drug_indices_end":[62,74,89]}
{"index":352,"text":"As SD , donepezil , galantamine , rivastigmine , and memantine are now usable .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["donepezil","galantamine","rivastigmine","memantine"],"drug_indices_start":[8,20,34,53],"drug_indices_end":[17,31,46,62]}
{"index":353,"text":"Raloxifene is a selective estrogen receptor modulator which is structurally similar to tamoxifen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Raloxifene","tamoxifen"],"drug_indices_start":[0,87],"drug_indices_end":[10,96]}
{"index":354,"text":"Recipients received the dual endothelin-1 ( ET-1 ) receptor blocker , bosentan ( 100 mg\/kg ) , the angiotensin-converting enzyme ( ACE ) inhibitor , ramipril ( 5 mg\/kg ) , bosentan plus ramipril ( doses as just noted ) or vehicle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["endothelin-1","bosentan","ramipril","bosentan","ramipril"],"drug_indices_start":[29,70,149,172,186],"drug_indices_end":[41,78,157,180,194]}
{"index":355,"text":"After surgery , she received a sequential chemotherapy , ie , intraabdominal injection of carboplatin ( CBDCA 300 mg\/m2 ) and div administration of paclitaxel ( PTX 180 mg\/m2 ) as a standard regimen for advanced ovarian cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel"],"drug_indices_start":[90,148],"drug_indices_end":[101,158]}
{"index":356,"text":"They are now sufficiently detailed to have been of use in the development of new drug compounds like ranolazine and ivabradine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ranolazine","ivabradine"],"drug_indices_start":[101,116],"drug_indices_end":[111,126]}
{"index":357,"text":"Based on clinical knowledge , we re-prioritized 30 potentially repurposable drugs against COVID-19 ( including pseudoephedrine , andrographolide , chloroquine , abacavir , and thalidomide ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pseudoephedrine","andrographolide","chloroquine","abacavir","thalidomide"],"drug_indices_start":[111,129,147,161,176],"drug_indices_end":[126,144,158,169,187]}
{"index":358,"text":"To study the release of free endotoxin from Escherichia coli exposed to varying concentrations of the penicillin-binding protein ( PBP ) 3-specific beta-lactam antibiotic cefuroxime , the aminoglycoside tobramycin , and a combination of the two , and to test the relationship between bacterial killing rate and endotoxin release .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefuroxime","tobramycin"],"drug_indices_start":[171,203],"drug_indices_end":[181,213]}
{"index":359,"text":"As CDK7 inhibitors are currently under clinical evaluation in patients , our data suggest the addition of the TKI ponatinib or lapatinib in CDK7 inhibitor clinical trials in patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ponatinib","lapatinib","CDK7 inhibitor"],"drug_indices_start":[114,127,140],"drug_indices_end":[123,136,154]}
{"index":360,"text":"An effective treatment for operable breast cancer , NCT with epirubicin plus paclitaxel results in significant downstaging or eliminating of primary tumors in breast cancer , thus expanding the indication of breast conservation therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epirubicin","paclitaxel"],"drug_indices_start":[61,77],"drug_indices_end":[71,87]}
{"index":361,"text":"Carboplatin and etoposide for recurrent malignant glioma following surgical and radiotherapy failure : A clinical study conducted at the Northern Israel Oncology Center .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Carboplatin","etoposide"],"drug_indices_start":[0,16],"drug_indices_end":[11,25]}
{"index":362,"text":"ABC transporter inhibition plus dexamethasone enhances the efficacy of CED dasatinib , resulting in enhanced tumor cellular apoptosis and improved survival in H3.3K27 M mutant DIPG .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexamethasone","dasatinib"],"drug_indices_start":[32,75],"drug_indices_end":[45,84]}
{"index":363,"text":"Those who received prednisone alone could have mitoxantrone added after 6 weeks if there was no improvement in pain .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisone","mitoxantrone"],"drug_indices_start":[19,47],"drug_indices_end":[29,59]}
{"index":364,"text":"Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["imatinib","cytarabine"],"drug_indices_start":[49,71],"drug_indices_end":[57,81]}
{"index":365,"text":"Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine : a multicenter , phase II trial of the Swiss Group for Clinical Cancer Research .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","capecitabine"],"drug_indices_start":[84,101],"drug_indices_end":[95,113]}
{"index":366,"text":"as neoadjuvant chemotherapy , and two cycles of doxorubicin\/cisplatin and ifosfamide , and two cycles of high-dose methotrexate ( 10 - 12 g\/m(2 ) ) were given post-operatively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin\/cisplatin","ifosfamide","methotrexate"],"drug_indices_start":[48,74,115],"drug_indices_end":[69,84,127]}
{"index":368,"text":"Patients with wild-type KRAS exon 2 mCRC previously treated with fluorouracil- , oxaliplatin- and irinotecan-based chemotherapies were randomised ( 1:1 ) to either panitumumab plus irinotecan ( panitumumab arm ) or cetuximab plus irinotecan ( cetuximab arm ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil-","oxaliplatin-","irinotecan-based","panitumumab","irinotecan","panitumumab","cetuximab","irinotecan","cetuximab"],"drug_indices_start":[65,81,98,164,181,194,215,230,243],"drug_indices_end":[78,93,114,175,191,205,224,240,252]}
{"index":369,"text":"Epirubicin , oxaliplatin , and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer ( REAL3 ):","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Epirubicin","oxaliplatin","capecitabine","panitumumab"],"drug_indices_start":[0,13,31,60],"drug_indices_end":[10,24,43,71]}
{"index":371,"text":"CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab ( FIRE-3 trial ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["FOLFIRI","cetuximab","bevacizumab"],"drug_indices_start":[176,189,202],"drug_indices_end":[183,198,213]}
{"index":372,"text":"The Tamoxifen Exemestane Adjuvant Multinational ( TEAM ) phase 3 trial was conducted in hospitals in nine countries .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Tamoxifen","Exemestane"],"drug_indices_start":[4,14],"drug_indices_end":[13,24]}
{"index":373,"text":"Patients used 2.16 ( range 0.0 - 6.3 ) formoterol and 2.34 ( range 0.1 - 7.5 ) terbutaline relief inhalations x day(-1 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["formoterol","terbutaline"],"drug_indices_start":[39,79],"drug_indices_end":[49,90]}
{"index":374,"text":"Preoperative chemotherapy with FLOT ( 5-FU , leucovorin , oxaliplatin and docetaxel ) without radiation therapy is the standard treatment in the West .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-FU","leucovorin","oxaliplatin","docetaxel"],"drug_indices_start":[38,45,58,74],"drug_indices_end":[42,55,69,83]}
{"index":375,"text":"The third-generation aromatase inhibitors ( AIs ) , including anastrozole , exemestane and letrozole , have demonstrated improved efficacy versus tamoxifen for the adjuvant endocrine treatment of postmenopausal patients with hormone receptor-positive breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","exemestane","letrozole","tamoxifen"],"drug_indices_start":[62,76,91,146],"drug_indices_end":[73,86,100,155]}
{"index":376,"text":"Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Digoxin","gemcitabine"],"drug_indices_start":[0,68],"drug_indices_end":[7,79]}
{"index":377,"text":"Tumor suppression was further enhanced when rapamycin was combined with 5-fluorouracil and\/or oxaliplatin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rapamycin","5-fluorouracil","oxaliplatin"],"drug_indices_start":[44,72,94],"drug_indices_end":[53,86,105]}
{"index":378,"text":"These structural motifs represent typical azoles , such as econazole , fluconazole , and metyrapone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["econazole","fluconazole","metyrapone"],"drug_indices_start":[59,71,89],"drug_indices_end":[68,82,99]}
{"index":379,"text":"The present systematic review and network meta-analysis was performed to conduct indirect comparisons on efficacy and safety profile among ICIs , including atezolizumab , durvalumab , pembrolizumab , and nivolumab as first-line treatment in patients with ES-SCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atezolizumab","durvalumab","pembrolizumab","nivolumab"],"drug_indices_start":[156,171,184,204],"drug_indices_end":[168,181,197,213]}
{"index":380,"text":"Metformin inhibits obesity but has no effect in reducing myocardial hypertrophy caused by Rosiglitazone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Metformin","Rosiglitazone"],"drug_indices_start":[0,90],"drug_indices_end":[9,103]}
{"index":381,"text":"The primary endpoint of this study was to determine the maximal tolerated dose of the combination of dose-escalating curcumin and standard dose of docetaxel chemotherapy in advanced and metastatic breast cancer patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","docetaxel"],"drug_indices_start":[117,147],"drug_indices_end":[125,156]}
{"index":382,"text":"The subjects were then randomly assigned to treatment with either propranolol or metoprolol and repeated the exercise protocol after 1 week of treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","metoprolol"],"drug_indices_start":[66,81],"drug_indices_end":[77,91]}
{"index":383,"text":"This case highlights the potential efficacy of combining nivolumab and regorafenib in the treatment of SBAs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","regorafenib"],"drug_indices_start":[57,71],"drug_indices_end":[66,82]}
{"index":384,"text":"Of the substances tested for inhibition of 11beta-HSD-I and -II , chenodeoxycholic acid was the only one that selectively inhibited 11beta-HSD-I ( IC(50 ) for reduction : 2.8x10(-6)mol\/l , IC(50 ) for oxidation : 4.4x10(-6)mol\/l ) , whereas ketoconazole preferentially inhibited oxidation and reduction reactions catalyzed by 11beta-HSD-II .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chenodeoxycholic","ketoconazole"],"drug_indices_start":[66,241],"drug_indices_end":[82,253]}
{"index":385,"text":"Anti-tumor effects of etoposide ( VP-16 ) , vincristine and mitomycin C were evaluated with four human neuroblastoma xenograft , according to Battelle Columbus Laboratories protocol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","vincristine","mitomycin"],"drug_indices_start":[22,44,60],"drug_indices_end":[31,55,69]}
{"index":386,"text":"Biliary bile acids were mainly amidates of cholic acid and chenodeoxycholic acid , with the former predominating .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cholic","chenodeoxycholic"],"drug_indices_start":[43,59],"drug_indices_end":[49,75]}
{"index":387,"text":"Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vancomycin","rifampin"],"drug_indices_start":[79,94],"drug_indices_end":[89,102]}
{"index":388,"text":"Our findings suggest that roflumilast reduces exacerbations and hospital admissions in patients with severe chronic obstructive pulmonary disease and chronic bronchitis who are at risk of frequent and severe exacerbations despite inhaled corticosteroid and longacting \u03b22 agonist therapy , even in combination with tiotropium .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["roflumilast","tiotropium"],"drug_indices_start":[26,314],"drug_indices_end":[37,324]}
{"index":390,"text":"Induction chemotherapy with cisplatin , doxorubicin , and cyclophosphamide ( CAP ) in a combined modality approach for locally advanced and inflammatory breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","doxorubicin","cyclophosphamide"],"drug_indices_start":[28,40,58],"drug_indices_end":[37,51,74]}
{"index":391,"text":"Methotrexate was efficient in one patient , hydroxychloroquine showed benefit in only 1 out of 3 patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Methotrexate","hydroxychloroquine"],"drug_indices_start":[0,44],"drug_indices_end":[12,62]}
{"index":392,"text":"Our results show high rates of DR-TB in Nigerian HIV-infected individuals ( 7.0 % for rifampin [ RIF ] and 9.3 % for RIF or isoniazid [ INH ] ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rifampin","isoniazid"],"drug_indices_start":[86,124],"drug_indices_end":[94,133]}
{"index":393,"text":"Sorafenib is an orally active multikinase inhibitor , and bortezomib is a proteasome inhibitor that affects multiple signaling pathways .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sorafenib","bortezomib"],"drug_indices_start":[0,58],"drug_indices_end":[9,68]}
{"index":394,"text":"Hypertensive rats in separate groups were treated with either candesartan ( 1 mg\/kg body weight ) alone or a combination of candesartan ( 1 mg\/kg body weight ) and rofecoxib ( 10 mg\/kg body weight ) orally and daily for 6 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["candesartan","candesartan","rofecoxib"],"drug_indices_start":[62,124,164],"drug_indices_end":[73,135,173]}
{"index":395,"text":"The highest weight gain in the cyclophosphamide , methotrexate and fluorouracil group was 2\u00b79 kg ( 5 % ) vs. 0\u00b79 kg ( 1 % ) in the anthracycline-based group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","methotrexate","fluorouracil"],"drug_indices_start":[31,50,67],"drug_indices_end":[47,62,79]}
{"index":396,"text":"Treatment of relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma with everolimus ( RAD001 ) and alemtuzumab : a Phase I\/II study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["everolimus","alemtuzumab"],"drug_indices_start":[94,120],"drug_indices_end":[104,131]}
{"index":397,"text":"Since primary amines similar to that of lisinopril readily form Schiff bases with acetaldehyde , these data suggest that both captopril and lisinopril may act to detoxify the acetaldehyde effect upon plasma , albeit by different mechanisms .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lisinopril","captopril","lisinopril"],"drug_indices_start":[40,126,140],"drug_indices_end":[50,135,150]}
{"index":398,"text":"Capecitabine and oxaliplatin have been shown to be as effective as fluorouracil and cisplatin , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Capecitabine","oxaliplatin","fluorouracil","cisplatin"],"drug_indices_start":[0,17,67,84],"drug_indices_end":[12,28,79,93]}
{"index":399,"text":"To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol , methadone , morphine or tramadol in healthy sheep .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexmedetomidine","butorphanol","methadone","morphine","tramadol"],"drug_indices_start":[76,106,120,132,144],"drug_indices_end":[91,117,129,140,152]}
{"index":401,"text":"It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cytosine arabinoside","vincristine","prednisone"],"drug_indices_start":[22,63,79],"drug_indices_end":[42,74,89]}
{"index":402,"text":"Patients were categorized into 10 groups according to the index OAC ( warfarin , rivaroxaban , dabigatran , apixaban , and edoxaban ) and whether or not they received PPI co-therapy , and were followed up for incidence of major GIB .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["warfarin","rivaroxaban","dabigatran","apixaban","edoxaban"],"drug_indices_start":[70,81,95,108,123],"drug_indices_end":[78,92,105,116,131]}
{"index":403,"text":"Celecoxib induced a synergistic or an additive cytotoxic effect in combination with doxorubicin , etoposide , irinotecan or vincristine in vitro .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Celecoxib","doxorubicin","etoposide","irinotecan","vincristine"],"drug_indices_start":[0,84,98,110,124],"drug_indices_end":[9,95,107,120,135]}
{"index":404,"text":"In vivo , midostaurin alone powerfully prolonged the survival of mice bearing the resistant BL cells compared to rituximab alone treatments .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["midostaurin","rituximab"],"drug_indices_start":[10,113],"drug_indices_end":[21,122]}
{"index":405,"text":"Treatment of GIST882-R with imatinib in combination with gefitinib , an EGFR inhibitor , partially prevented cell growth , implying that EGFR may be involved in acquisition of secondary imatinib resistance in GIST .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["imatinib","gefitinib","imatinib"],"drug_indices_start":[28,57,186],"drug_indices_end":[36,66,194]}
{"index":406,"text":"This is the first paper suggesting the possibility of combination treatment of tamoxifen with risperidone in breast cancer patients , providing a conceivable resolution of tamoxifen-induced side effects without interfering the efficacy of tamoxifen against breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamoxifen","risperidone","tamoxifen"],"drug_indices_start":[79,94,239],"drug_indices_end":[88,105,248]}
{"index":407,"text":"Amoxicillin , erythromycin , and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains but lower on biofilm-associated organisms in 2 strains and null against the third .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Amoxicillin","erythromycin","levofloxacin"],"drug_indices_start":[0,14,33],"drug_indices_end":[11,26,45]}
{"index":408,"text":"A double-blind , parallel , placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine , triprolidine , and the sympathomimetic , pseudoephedrine , in the treatment of allergic rhinitis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["triprolidine","pseudoephedrine"],"drug_indices_start":[151,192],"drug_indices_end":[163,207]}
{"index":410,"text":"This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","trastuzumab"],"drug_indices_start":[114,130,150],"drug_indices_end":[124,141,161]}
{"index":411,"text":"High response rate and acceptable toxicity of a combination of rituximab , vinorelbine , ifosfamide , mitoxantrone and prednisone for the treatment of diffuse large B-cell lymphoma in first relapse : results of the R-NIMP GOELAMS study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","vinorelbine","ifosfamide","mitoxantrone","prednisone"],"drug_indices_start":[63,75,89,102,119],"drug_indices_end":[72,86,99,114,129]}
{"index":412,"text":"A second complete remission was obtained with RFC chemotherapy regimen ( rituximab , fludarabine , and cyclophosphamide ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","fludarabine","cyclophosphamide"],"drug_indices_start":[73,85,103],"drug_indices_end":[82,96,119]}
{"index":413,"text":"At a median duration of follow-up of 18.2 months , anastrozole was at least equivalent to tamoxifen in terms of median TTP ( 8.5 and 7.0 months , respectively ; estimated hazard ratio [ tamoxifen relative to anastrozole ] , 1.13 [ lower 95 % confidence level , 1.00 ] ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","tamoxifen","tamoxifen","anastrozole"],"drug_indices_start":[51,90,186,208],"drug_indices_end":[62,99,195,219]}
{"index":414,"text":"A favourable response to chemotherapy can be expected in up to 60 % of patients receiving a combination of streptozocin plus doxorubicin , and in up to 40 % of patients receiving dacarbazine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["streptozocin","doxorubicin","dacarbazine"],"drug_indices_start":[107,125,179],"drug_indices_end":[119,136,190]}
{"index":415,"text":"A substantial literature now strongly supports the specific involvement of serotonin 5-HT(1B ) and 5-HT(2C ) receptor subtypes in satiety and in the anorectic effect of agents such as fenfluramine and fluoxetine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fenfluramine","fluoxetine"],"drug_indices_start":[184,201],"drug_indices_end":[196,211]}
{"index":416,"text":"Pilocarpine also induced secretion at a concentration as low as 1 \u03bcM and was the most powerful secretagogue at 10 \u03bcM. Secretion was induced by carbachol at 0.1 \u03bcM , with maximum secretion at 1.0 \u03bcM.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Pilocarpine","carbachol"],"drug_indices_start":[0,143],"drug_indices_end":[11,152]}
{"index":417,"text":"This phase II study was conducted to establish whether induction chemotherapy with carboplatin ( CBDCA ) and paclitaxel ( PTX ) plus bevacizumab prior to surgery reduces the risk of progression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel","bevacizumab"],"drug_indices_start":[83,109,133],"drug_indices_end":[94,119,144]}
{"index":418,"text":"In women of childbearing potential , valproate should be considered if levetiracetam and lamotrigine have failed to control seizures at this stage .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["valproate","levetiracetam","lamotrigine"],"drug_indices_start":[37,71,89],"drug_indices_end":[46,84,100]}
{"index":419,"text":"Patients with clinically localized , intermediate- or high-grade non-Hodgkin 's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","vincristine","prednisone"],"drug_indices_start":[169,188,202,220],"drug_indices_end":[185,199,213,230]}
{"index":420,"text":"To evaluate the effects of a fixed combination of olmesartan\/amlodipine compared with olmesartan or amlodipine alone on some parameters of endothelial damage in diabetic , hypertensive patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olmesartan","amlodipine"],"drug_indices_start":[86,100],"drug_indices_end":[96,110]}
{"index":421,"text":"Numerous phase II and III clinical trials have demonstrated a higher activity of combined gemcitabine plus docetaxel schedules against non-small cell lung cancer ( NSCLC ) than that of both agents in monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","docetaxel"],"drug_indices_start":[90,107],"drug_indices_end":[101,116]}
{"index":422,"text":"The use of HDCT-SCT in CNS metastases needs to be carefully considered , possibly by adding thiotepa or topotecan to improve tumor control .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["thiotepa","topotecan"],"drug_indices_start":[92,104],"drug_indices_end":[100,113]}
{"index":424,"text":"We performed a retrospective analysis of 114 severely head injured patients who were admitted to the neurocritical care unit of Level 1 trauma center and who received vasopressors ( phenylephrine , norepinephrine , dopamine , vasopressin or epinephrine ) to increase blood pressure","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["phenylephrine","vasopressin","epinephrine"],"drug_indices_start":[182,226,241],"drug_indices_end":[195,237,252]}
{"index":425,"text":"While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20 % , the administration of combinations of irinotecan with 5-fluorouracil\/folinic acid or oxaliplatin with 5-fluorouracil\/folinic acid results in significantly increased response rates and improved survival .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","oxaliplatin","5-fluorouracil\/folinic","5-fluorouracil\/folinic"],"drug_indices_start":[171,187,218,235],"drug_indices_end":[181,209,229,257]}
{"index":426,"text":"Chemotherapy was given in 405 of 410 treatment periods with dacarbazine , fotemustine , vindesine , carboplatin and temozolomide in different schedules .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dacarbazine","carboplatin","temozolomide"],"drug_indices_start":[60,100,116],"drug_indices_end":[71,111,128]}
{"index":427,"text":"[ Effect of nedaplatin , 5-FU , and leucovorin combined with radiation therapy in unresectable esophageal carcinoma ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nedaplatin","leucovorin","5-FU"],"drug_indices_start":[12,25,36],"drug_indices_end":[22,29,46]}
{"index":428,"text":"After 5 years , approximately 30.8 % of etanercept patients and 68.8 % of monoclonal antibody patients ( adalimumab 71.2 % ; infliximab 67.2 % ) were still being treated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etanercept","adalimumab","infliximab"],"drug_indices_start":[40,105,125],"drug_indices_end":[50,115,135]}
{"index":429,"text":"( 4 mg\/day ) ; in group 3 , 69 patients administered metformin ( 1,000 mg\/day ) and rosiglitazone ( 4 mg\/day ) for 6 months ,","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metformin","rosiglitazone"],"drug_indices_start":[53,84],"drug_indices_end":[62,97]}
{"index":430,"text":"In the intention-to-treat analysis , 57 % of patients that received tenecteplase and 53 % of patients that received alteplase reached good functional outcome ( modified Rankin Scale score of 0 - 1 ) at 3 months ( odds ratio , 1.19 ; 95 % CI , 0.68 - 2.10 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tenecteplase","alteplase"],"drug_indices_start":[68,116],"drug_indices_end":[80,125]}
{"index":431,"text":"The patient was treated with dexamethasone and ethinyl estradiol with cessation of anti-hypertensive therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexamethasone","ethinyl"],"drug_indices_start":[29,47],"drug_indices_end":[42,54]}
{"index":432,"text":"Exposure of bss1 to clinically-used antiepileptic drugs ( phenytoin or gabapentin ) significantly reduces synchrony .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["phenytoin","gabapentin"],"drug_indices_start":[58,71],"drug_indices_end":[67,81]}
{"index":433,"text":"When compared with the combination of amphotericin B plus flucytosine , fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphotericin","flucytosine","fluconazole"],"drug_indices_start":[38,58,72],"drug_indices_end":[50,69,83]}
{"index":434,"text":"Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside , vincristine , and prednisone ( ROAP ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rubidazone","cytosine arabinoside","vincristine","prednisone"],"drug_indices_start":[97,112,135,153],"drug_indices_end":[107,132,146,163]}
{"index":435,"text":"Patients progressing after first-line chemotherapy are treated with docetaxel , pemetrexed or erlotinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","pemetrexed","erlotinib"],"drug_indices_start":[68,80,94],"drug_indices_end":[77,90,103]}
{"index":436,"text":"To compare the therapeutic effect of \u03b1(2 ) and \u03b1(4 ) integrin-blocking antibodies to conventional inflammatory bowel disease drugs methotrexate , 5-aminosalicylic acid and azathioprine in the dextran sulphate sodium mouse colitis model .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","5-aminosalicylic acid","azathioprine"],"drug_indices_start":[131,146,172],"drug_indices_end":[143,167,184]}
{"index":437,"text":"Further analyses demonstrated that gemcitabine could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel is administered before gemcitabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","paclitaxel","paclitaxel","gemcitabine"],"drug_indices_start":[35,107,173,207],"drug_indices_end":[46,117,183,218]}
{"index":438,"text":"Standard anticonvulsants such as phenytoin , the barbiturates , carbamazepine , and the succinimides have been ineffective .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["phenytoin","carbamazepine"],"drug_indices_start":[33,64],"drug_indices_end":[42,77]}
{"index":439,"text":"Molecular targeting of Aurora A by curcumin restores chemosensitivity by increasing the efficacy of doxorubicin in breast cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","doxorubicin"],"drug_indices_start":[35,100],"drug_indices_end":[43,111]}
{"index":440,"text":"Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Daratumumab","Lenalidomide","Dexamethasone"],"drug_indices_start":[0,17,34],"drug_indices_end":[11,29,47]}
{"index":441,"text":"Noninferiority was concluded if the lower limit of the 2-sided 95 % CI for the difference ( doripenem minus meropenem ) in the proportion of patients classified as clinical cures was > or=-15 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doripenem","meropenem"],"drug_indices_start":[92,108],"drug_indices_end":[101,117]}
{"index":442,"text":"We further illustrate the practical considerations of managing irAEs by presenting three cases of immune-related toxicity in melanoma patients treated with nivolumab or pembrolizumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","pembrolizumab"],"drug_indices_start":[156,169],"drug_indices_end":[165,182]}
{"index":443,"text":"Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel","lonafarnib"],"drug_indices_start":[29,45,72],"drug_indices_end":[40,55,82]}
{"index":444,"text":"One subject who received oxaprozin for 12 days and , in addition , aspirin for the last five days developed a rash that subsided after both drugs were discontinued ; one subject treated with aspirin experienced tinnitus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaprozin","aspirin","aspirin"],"drug_indices_start":[25,67,191],"drug_indices_end":[34,74,198]}
{"index":445,"text":"To determine the long-term tolerability of prophylactic administration of pyrazinamide and levofloxacin in patients possibly exposed to multidrug-resistant tuberculosis ( MDRTB ) after undergoing solid organ transplantation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pyrazinamide","levofloxacin"],"drug_indices_start":[74,91],"drug_indices_end":[86,103]}
{"index":446,"text":"Additive effect of the combination of griseofulvin and ketoconazole against Microsporum canis in vitro .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["griseofulvin","ketoconazole"],"drug_indices_start":[38,55],"drug_indices_end":[50,67]}
{"index":447,"text":"Aprepitant plus ondansetron may increase acute-CR , may have benefit regarding CINV 's effect on QoL , and is safe for 5-day temozolomide compared to ondansetron .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aprepitant","ondansetron","temozolomide","ondansetron"],"drug_indices_start":[0,16,125,150],"drug_indices_end":[10,27,137,161]}
{"index":448,"text":"Finally , a further synergistically improved myeloma cell lysis with the daratumumab-IPH2102 combination was observed by adding lenalidomide , which suggests that more effective treatment strategies can be designed for multiple myeloma by combining daratumumab with agents that independently modulate natural killer cell function .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lenalidomide","daratumumab"],"drug_indices_start":[128,249],"drug_indices_end":[140,260]}
{"index":449,"text":"Both liposomal doxorubicin ( LD ) and docetaxel ( D ) have a broad range of activity against solid tumors , including advanced pancreatic cancer ( APC ) , as single agents , while their combination has produced encouraging response rates in the treatment of several malignancies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","docetaxel"],"drug_indices_start":[15,38],"drug_indices_end":[26,47]}
{"index":450,"text":"Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ranitidine","lansoprazole"],"drug_indices_start":[20,34],"drug_indices_end":[30,46]}
{"index":451,"text":"A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cimetidine","L-carnitine"],"drug_indices_start":[25,40],"drug_indices_end":[35,51]}
{"index":452,"text":"Importantly , MAPK and\/or MTOR complex1 ( MTORC1 ) activity were upregulated in AML cells made resistant to several FLT3 inhibitors , including crenolanib , quizartinib , or sorafenib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["crenolanib","quizartinib","sorafenib"],"drug_indices_start":[144,157,174],"drug_indices_end":[154,168,183]}
{"index":453,"text":"We tested whether varenicline , a partial nicotine agonist , would also increase future quit attempts .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["varenicline","nicotine"],"drug_indices_start":[18,42],"drug_indices_end":[29,50]}
{"index":454,"text":"However , combination of pioglitazone and sulfasalazine has shown greater efficacy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pioglitazone","sulfasalazine"],"drug_indices_start":[25,42],"drug_indices_end":[37,55]}
{"index":455,"text":"At time 2 , genotypic resistance to zidovudine was found in 11 out of 12 cases ( 41L : two cases ; 41L , 215Y : six cases ; 41L , 210W , 215Y : two cases ; M41L , D67N , L210W , T215Y : one case ) with a mean 18.9 + \/- 8.8-fold increase in the IC50 to zidovudine and 1.4 + \/- 0.4-fold to stavudine","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["zidovudine","zidovudine","stavudine"],"drug_indices_start":[36,252,288],"drug_indices_end":[46,262,297]}
{"index":456,"text":"Phase II Study of Sorafenib Combined with Concurrent Hepatic Arterial Infusion of Oxaliplatin , 5-Fluorouracil and Leucovorin for Unresectable Hepatocellular Carcinoma with Major Portal Vein Thrombosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sorafenib","Oxaliplatin","5-Fluorouracil","Leucovorin"],"drug_indices_start":[18,82,96,115],"drug_indices_end":[27,93,110,125]}
{"index":457,"text":"Sprague-Dawley male rats were treated with levodopa ( LD ) , betaine ( Bet ) , levodopa plus betaine ( LD\/Bet ) , levodopa plus benserazide ( LD\/Ben ) , levodopa plus betaine-benserazide ( LD\/Bet-Ben ) , and the controls with vehicle for 10 consecutive days , orally .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levodopa","betaine","levodopa","betaine","levodopa","benserazide","levodopa","betaine-benserazide"],"drug_indices_start":[43,61,79,93,114,128,153,167],"drug_indices_end":[51,68,87,100,122,139,161,186]}
{"index":458,"text":"We designed a phase I trial to determine the maximum-tolerated dose ( MTD ) and pharmacodynamic effects of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer refractory to standard therapies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cixutumumab","temsirolimus"],"drug_indices_start":[127,159],"drug_indices_end":[138,171]}
{"index":459,"text":"Forty-seven percent of patients were sequentially treated with an amphotericin B-containing product followed by itraconazole , 31 % received itraconazole alone , and 7 % received an amphotericin B-containing product only .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphotericin","itraconazole","itraconazole","amphotericin"],"drug_indices_start":[66,112,141,182],"drug_indices_end":[78,124,153,194]}
{"index":460,"text":"From August 2008 to May 2011 , consecutive chemo-na\u00efve patients with stage IV non-squamous non-small cell lung cancer ( NSCLC ) received pemetrexed 500mg\/m(2 ) , oxaliplatin 100mg\/m(2 ) and bevacizumab 7.5mg\/kg every 3 weeks for 6 cycles , in the outpatient setting .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pemetrexed","oxaliplatin","bevacizumab"],"drug_indices_start":[137,162,190],"drug_indices_end":[147,173,201]}
{"index":461,"text":"To determine if antiseptic central venous catheters impregnated with silver sulfadiazine and chlorhexidine ( antiseptic ) reduce bacterial adherence and biofilm formation without producing local or systemic toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sulfadiazine","chlorhexidine"],"drug_indices_start":[76,93],"drug_indices_end":[88,106]}
{"index":462,"text":"In multivariate analysis , LDP and LAP were significantly associated with stavudine ( d4 T ) use , while LAP was also associated with zidovudine ( ZDV ) treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["stavudine","zidovudine"],"drug_indices_start":[74,134],"drug_indices_end":[83,144]}
{"index":463,"text":"KARs , new semisynthetic antitumor bis-indole derivatives , were found to be inhibitors of tubulin polymerization with lower toxicity than vinblastine or vincristine , used in chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinblastine","vincristine"],"drug_indices_start":[139,154],"drug_indices_end":[150,165]}
{"index":464,"text":"More than one-third ( 36 % ) of AA patients in our study received Danazol as monotherapy , whereas less than a third ( 32 % ) each received standard doses of IST with equine Anti Thymocyte Globulin ( ATG ) and Cyclosporine combination , or Cyclosporine and Danazol combination , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Danazol","Anti Thymocyte Globulin","Cyclosporine","Cyclosporine","Danazol"],"drug_indices_start":[66,174,210,240,257],"drug_indices_end":[73,197,222,252,264]}
{"index":465,"text":"Similarly , antibodies raised against CYP3A4 almost completely abolished colchicine demethylation and nifedipine oxidase activity , but preimmune IgG had no effect .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["colchicine","nifedipine"],"drug_indices_start":[73,102],"drug_indices_end":[83,112]}
{"index":466,"text":"Furthermore , our group has shown that the combination of paclitaxel and carboplatin is effective in anthracycline-resistant ABC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[58,73],"drug_indices_end":[68,84]}
{"index":467,"text":"Cyclosporine ( 25 mg\/kg per day , s.c . ) was given for 7 days to rats either alone or in combination with resveratrol ( 10 mg\/kg per day , i.p . ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cyclosporine","resveratrol"],"drug_indices_start":[0,107],"drug_indices_end":[12,118]}
{"index":468,"text":"The diagnosis was confirmed by comparative double diagnostic block of the medial branch with bupivacaine and lidocaine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","lidocaine"],"drug_indices_start":[93,109],"drug_indices_end":[104,118]}
{"index":469,"text":"Pemetrexed with bortezomib is feasible and tolerable at recommended single-agent doses .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Pemetrexed","bortezomib"],"drug_indices_start":[0,16],"drug_indices_end":[10,26]}
{"index":470,"text":"Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy ( TANIA ): an open-label , randomised phase 3 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","bevacizumab","TANIA"],"drug_indices_start":[0,191,223],"drug_indices_end":[11,202,228]}
{"index":471,"text":"Goserelin plus tamoxifen after cyclophosphamide , doxorubicin and 5-fluorouracil ( CAF ) chemotherapy resulted in improved disease-free survival compared with CAF alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Goserelin","tamoxifen","cyclophosphamide","doxorubicin","5-fluorouracil"],"drug_indices_start":[0,15,31,50,66],"drug_indices_end":[9,24,47,61,80]}
{"index":472,"text":"An 82-year-old white female developed a 36-hour episode of unresponsiveness\/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["triazolam","cimetidine"],"drug_indices_start":[110,147],"drug_indices_end":[119,157]}
{"index":473,"text":"The combination of melatonin at concentrations of 50 \u03bcM with increasing doses of irinotecan ( 7.5 , 15 , 30 , and 60 \u03bcM ) resulted in an increase in the amount of DNA damage in A549 and HT29 cancer cells , but was not effective in inducing DNA damage in healthy human lymphocytes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["melatonin","irinotecan"],"drug_indices_start":[19,81],"drug_indices_end":[28,91]}
{"index":474,"text":"Peripheral blood progenitor cells were harvested by leukapheresis after treatment with cyclophosphamide and filgrastim and then re-infused after the high-dose cycle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","filgrastim"],"drug_indices_start":[87,108],"drug_indices_end":[103,118]}
{"index":475,"text":"Although cisplatin is generally the favoured platinum agent , gemcitabine partnered with carboplatin is convenient to administer and has a favourable toxicity profile .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","gemcitabine","carboplatin"],"drug_indices_start":[9,62,89],"drug_indices_end":[18,73,100]}
{"index":476,"text":"In group B , epirubicin 90 mg\/m2 was combined with paclitaxel 175 mg\/m2 , given in the same manner as in group A.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epirubicin","paclitaxel"],"drug_indices_start":[13,51],"drug_indices_end":[23,61]}
{"index":477,"text":"We assessed the safety and activity of ceritinib plus nivolumab in these patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ceritinib","nivolumab"],"drug_indices_start":[39,54],"drug_indices_end":[48,63]}
{"index":478,"text":"Incubation with somatostatin , 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["somatostatin","decitabine","trichostatin","somatostatin"],"drug_indices_start":[16,37,52,78],"drug_indices_end":[28,47,64,90]}
{"index":479,"text":"This study was conducted to determine whether famotidine , a H2 antagonist , is effective in the treatment of acute urticaria and compare its effect with that of the H1 antagonist diphenhydramine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["famotidine","diphenhydramine"],"drug_indices_start":[46,180],"drug_indices_end":[56,195]}
{"index":480,"text":"On the other hand , a diphenylhydantoin-induced increase in the total number of specific benzodiazepine binding sites seems of minor importance since clonazepam ( with a high affinity for these sites ) and chlordiazepoxide ( with a low affinity ) were equipotent in the enhancement of the combined treatment efficacy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonazepam","chlordiazepoxide"],"drug_indices_start":[150,206],"drug_indices_end":[160,222]}
{"index":481,"text":"A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive , Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer ( NEO-ORB ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Letrozole","Alpelisib"],"drug_indices_start":[43,58],"drug_indices_end":[52,67]}
{"index":482,"text":"Treatment with bromocriptine and pyridoxine showed no improvement .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bromocriptine","pyridoxine"],"drug_indices_start":[15,33],"drug_indices_end":[28,43]}
{"index":483,"text":"Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole on susceptible and resistant Escherichia coli K-12 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trimethoprim","sulfamethoxazole"],"drug_indices_start":[25,68],"drug_indices_end":[37,84]}
{"index":484,"text":"New effective and well tolerated agents are urgently needed because of increasing resistance to antimalarials such as chloroquine and proguanil , and real and perceived intolerance to standard drugs such as mefloquine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","proguanil","mefloquine"],"drug_indices_start":[118,134,207],"drug_indices_end":[129,143,217]}
{"index":485,"text":"They were subsequently exposed to graded doses of cisplatin ( CP ) , etoposide ( VP-16 ) , Adriamycin ( ADR ) , cytarabine ( ara-C ) , cyclophosphamide ( CY ) , or camptothecin ( CAM ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","etoposide","cytarabine","cyclophosphamide"],"drug_indices_start":[50,69,112,135],"drug_indices_end":[59,78,122,151]}
{"index":486,"text":"In a phase II trial , patients with primary gastric cancer and clinical involvement of para-aortic nodes ( PAN ) were treated by neo-adjuvant chemotherapy with capecitabine and oxaliplatin combination , and responders were then submitted to gastrectomy with D2 lymphadenectomy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","oxaliplatin"],"drug_indices_start":[160,177],"drug_indices_end":[172,188]}
{"index":487,"text":"More myelotoxicity is observed with palbociclib and ribociclib , but more gastrointestinal toxicity is observed with abemaciclib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["palbociclib","ribociclib","abemaciclib"],"drug_indices_start":[36,52,117],"drug_indices_end":[47,62,128]}
{"index":488,"text":"Intraoperative epidural bupivacaine , intraoperative intravenous fentanyl use , time to first analgesia request , postoperative visual analogue scale pain scores , tramadol requirements and side-effects were recorded for 72 hours .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","tramadol"],"drug_indices_start":[24,164],"drug_indices_end":[35,172]}
{"index":489,"text":"Three eyes had both bevacizumab and ranibizumab ( 1.58 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","ranibizumab"],"drug_indices_start":[20,36],"drug_indices_end":[31,47]}
{"index":490,"text":"Newer treatment regimens , including etoposide , prednisone , vincristine , cyclophosphamide , doxorubicin , rituximab ( EPOCH-R ) , show promise for these patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","prednisone","vincristine","cyclophosphamide","doxorubicin","rituximab"],"drug_indices_start":[37,49,62,76,95,109],"drug_indices_end":[46,59,73,92,106,118]}
{"index":491,"text":"In two groups of rats , propranolol or atropine were given before the venom administration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","atropine"],"drug_indices_start":[24,39],"drug_indices_end":[35,47]}
{"index":492,"text":"Doxycycline and azithromycin were highly effective in restoring fertility .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Doxycycline","azithromycin"],"drug_indices_start":[0,16],"drug_indices_end":[11,28]}
{"index":493,"text":"The pupillary dilation caused by amantadine is not abolished by pretreatment with reserpine , or by combined pretreatment with reserpine and alpha-methyl-p-tyrosine , although the mydriasis is reduced by approximately 25 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amantadine","reserpine","reserpine","alpha-methyl-p-tyrosine"],"drug_indices_start":[33,82,127,141],"drug_indices_end":[43,91,136,164]}
{"index":494,"text":"Rats were treated with curcumin for 23 days and etoposide was administered for the final 3 days of the experiment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","etoposide"],"drug_indices_start":[23,48],"drug_indices_end":[31,57]}
{"index":495,"text":"Combination Chemotherapy with Mitomycin C , Vinorelbine , and Cisplatin ( MVrP ) in Patients with Advanced Non-Small Cell Lung Cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mitomycin","Vinorelbine","Cisplatin"],"drug_indices_start":[30,44,62],"drug_indices_end":[39,55,71]}
{"index":496,"text":"Bitches were also treated with amoxicillin ( 15 mg\/kg body wt\/48 h ) and\/or gentamicin ( 4 mg\/kg body wt\/day ) administered as intramuscular ( i.m . ) injections .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amoxicillin","gentamicin"],"drug_indices_start":[31,76],"drug_indices_end":[42,86]}
{"index":497,"text":"So far , chloroquine , lopinavir , hydroxychloroquine , azithromycin , favipiravir , ribavirin , darunavir , remdesivir , and umifenovir have been tested in COVID-19 clinical trials .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","lopinavir","hydroxychloroquine","azithromycin","favipiravir","ribavirin","darunavir","remdesivir"],"drug_indices_start":[9,23,35,56,71,85,97,109],"drug_indices_end":[20,32,53,68,82,94,106,119]}
{"index":498,"text":"Of the currently known pure antiandrogens , bicalutamide offers some advantages over flutamide as it possesses a much longer half-life , allowing a once daily regimen , and has advantages over nilutamide in terms of fewer adverse effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bicalutamide","flutamide","nilutamide"],"drug_indices_start":[44,85,193],"drug_indices_end":[56,94,203]}
{"index":499,"text":"Fifty-seven patients with advanced measurable urothelial tract cancer , 52 of whom had an adequate trial , were treated weekly with 3 to 4 mg . per m.2 vinblastine and 30 to 40 mg . per m.2 methotrexate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinblastine","methotrexate"],"drug_indices_start":[152,190],"drug_indices_end":[163,202]}
{"index":500,"text":"The results indicate that bombesin and acetylcholine are the main intramural neural regulators of gastrin and somatostatin secretion .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bombesin","somatostatin"],"drug_indices_start":[26,110],"drug_indices_end":[34,122]}
{"index":501,"text":"Synergistic effects were seen between zeaxanthin and resveratrol or meclofenamic acid .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["resveratrol","meclofenamic acid","zeaxanthin"],"drug_indices_start":[38,53,68],"drug_indices_end":[48,64,85]}
{"index":503,"text":"Fifthteen patients were included : 12 underwent erlotinib treatment and 3 a crizotinib treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","crizotinib"],"drug_indices_start":[48,76],"drug_indices_end":[57,86]}
{"index":504,"text":"The combination of trastuzumab with paclitaxel ( Taxol ) is well approved .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","paclitaxel","Taxol"],"drug_indices_start":[19,36,49],"drug_indices_end":[30,46,54]}
{"index":505,"text":"Intensive regimen of combined immunosuppressive therapy ( high-dose corticosteroids , oral cyclosporin and intravenous cyclophosphamide ( IVCY , 900 - 1000 mg\/m(2 ) in every other week ) ) improved the survival rate of anti-MDA5-positive patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporin","cyclophosphamide","corticosteroids"],"drug_indices_start":[68,91,119],"drug_indices_end":[83,102,135]}
{"index":506,"text":"Drug sensitivity was associated with hsa-let-7a-5p for Bortezomib , hsa-miR-135a-3p for JNJ-707 and hsa-miR-185 - 3p for Panobinostat .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bortezomib","Panobinostat"],"drug_indices_start":[55,121],"drug_indices_end":[65,133]}
{"index":507,"text":"No previous case of pulmonary interstitial changes that appeared in association with regorafenib administration for HCC and that were exacerbated by subsequent treatment with lenvatinib has been reported .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["regorafenib","lenvatinib"],"drug_indices_start":[85,175],"drug_indices_end":[96,185]}
{"index":508,"text":"Treatment of articular manifestations of Lyme borreliosis is based on doxycycline , ceftriaxone , or amoxicillin for 28 days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxycycline","ceftriaxone","amoxicillin"],"drug_indices_start":[70,84,101],"drug_indices_end":[81,95,112]}
{"index":509,"text":"Serious adverse events were reported by 24 ( 34 % ) of 71 patients receiving olaparib and abiraterone ( seven of which were related to treatment ) and 13 ( 18 % ) of 71 patients receiving placebo and abiraterone ( one of which was related to treatment ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olaparib","abiraterone","abiraterone"],"drug_indices_start":[77,90,200],"drug_indices_end":[85,101,211]}
{"index":510,"text":"In autoperfused hindquarters , the pressor-response curve to noradrenaline was dose-dependently shifted to the left by propranolol and to the right by labetalol or prazosin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","labetalol","prazosin"],"drug_indices_start":[119,151,164],"drug_indices_end":[130,160,172]}
{"index":511,"text":"Expert opinion : Rivastigmine , a drug that increases cholinergic tone by inhibiting the enzyme cholinesterase , is effective for dementia , whereas the use of Donepezil is still in the realm of investigation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Rivastigmine","Donepezil"],"drug_indices_start":[17,160],"drug_indices_end":[29,169]}
{"index":512,"text":"Chemotherapy with methotrexate , cyclophosphamide , vincristine , doxorubicin , etoposide , and dexamethasone was effective , and the patient has been free from the disease for 1 year since completion of consolidation treatment with autologous peripheral blood stem cell transplantation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","cyclophosphamide","vincristine","doxorubicin","etoposide","dexamethasone"],"drug_indices_start":[18,33,52,66,80,96],"drug_indices_end":[30,49,63,77,89,109]}
{"index":513,"text":"We have examined whether the DNA-damaging agents etoposide ( VP-16 ) and doxorubicin can affect IL-8 , VEGF , and HIF-1 expressions in human melanoma cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin"],"drug_indices_start":[49,73],"drug_indices_end":[58,84]}
{"index":514,"text":"The effect of combined therapy with tamsulosin hydrochloride and meloxicam in patients with benign prostatic hyperplasia symptoms and impact on nocturia and sleep quality .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamsulosin","meloxicam"],"drug_indices_start":[36,65],"drug_indices_end":[46,74]}
{"index":515,"text":"We investigated two human ( RD2 and TE 671 ) cell lines by cultivating them with doxorubicin , cisplatinum , and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide","cisplatinum"],"drug_indices_start":[81,95,113],"drug_indices_end":[92,106,122]}
{"index":516,"text":"Retrospective study on antihyperlipidemic efficacy and safety of simvastatin , ezetimibe and their combination in Korean adults .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["simvastatin","ezetimibe"],"drug_indices_start":[65,79],"drug_indices_end":[76,88]}
{"index":517,"text":"The primary melanoma was surgically resected , and combination hepatic arterial infusion ( HAI ) therapy using dacarbazine , nimustine , vincristine ( DAV ) , and cisplatin was applied to the metastatic focus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dacarbazine","nimustine","vincristine","cisplatin"],"drug_indices_start":[111,125,137,163],"drug_indices_end":[122,134,148,172]}
{"index":518,"text":"These results were similar to those of previously reported salvage therapies for relapsed AML including intensive chemotherapy consisting of intermediate-dose Ara-C and sequential mitoxantrone with or without etoposide ( MC\/MEC ) , which we previously adopted .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ara-C","mitoxantrone","etoposide"],"drug_indices_start":[159,180,209],"drug_indices_end":[164,192,218]}
{"index":519,"text":"Sensitivity of the test samples to the anti-cancer drugs cisplatin ( CDDP ) , doxorubicin ( DXR ) and etoposide ( VP-16 ) was examined using the MTT\u00bf3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl [2H]-tetrazolium bromide \u00bf assay .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","CDDP","doxorubicin","DXR","etoposide","VP-16"],"drug_indices_start":[57,69,78,92,102,114],"drug_indices_end":[66,73,89,95,111,119]}
{"index":520,"text":"In this phase I study , we combined cyclophosphamide , alvocidib and rituximab ( CAR ) in a schema designed to mitigate tumor lysis syndrome ( TLS ) seen previously with alvocidib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","alvocidib","rituximab"],"drug_indices_start":[36,55,69],"drug_indices_end":[52,64,78]}
{"index":521,"text":"Newer-generation recombinant tissue-type plasminogen activators , such as desmoteplase and tenecteplase , will also help extend the time window .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["desmoteplase","tenecteplase"],"drug_indices_start":[74,91],"drug_indices_end":[86,103]}
{"index":522,"text":"Sixty-two analyzable patients with predominantly intermediate-grade non-Hodgkin lymphoma received cyclophosphamide ( 200 mg\/m(2 ) per day ) , doxorubicin ( 12.5 mg\/m(2 ) per day ) , and etoposide ( 60 mg\/m(2 ) per day ) ( CDE ) by continuous intravenous infusion for 4 days ( 96 hours ) every 3 weeks for a maximum of 8 cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","etoposide"],"drug_indices_start":[98,142,186],"drug_indices_end":[114,153,195]}
{"index":524,"text":"The combination carboplatin 35 mg\/m2 , etoposide 50 mg\/m2 , and ifosfamide 1,200 mg\/m2 was administered intravenously daily for 3 consecutive days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","etoposide","ifosfamide"],"drug_indices_start":[16,39,64],"drug_indices_end":[27,48,74]}
{"index":525,"text":"Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aspirin","tamoxifen"],"drug_indices_start":[0,62],"drug_indices_end":[7,71]}
{"index":526,"text":"Eighty-three patients were in the control group who have performed a surgical intervention with pre-operative 120-hour antibiotic prophylaxis by Claforan ( cefotaxime ) combining with Metrogel ( metronidazole ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefotaxime","metronidazole"],"drug_indices_start":[156,195],"drug_indices_end":[166,208]}
{"index":527,"text":"The regimen was CD DP 40 mg\/m2 day 1 and 6 , 5-FU 600 mg\/m2 day 2 and 4 , leucovorin 20 mg\/m2 day 2 and 4 , etoposide 60 mg\/m2 day 3 and 5 , and doxorubicin 20 mg\/m2 day 7 , with repetition every 28 days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["CD DP","leucovorin","etoposide","doxorubicin","5-FU"],"drug_indices_start":[16,45,74,108,145],"drug_indices_end":[21,49,84,117,156]}
{"index":528,"text":"A German Hodgkin 's lymphoma ( HL ) study group designed the BEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisolone ) regimen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","etoposide","doxorubicin","cyclophosphamide","vincristine","procarbazine","prednisolone"],"drug_indices_start":[71,83,95,109,128,142,157],"drug_indices_end":[80,92,106,125,139,154,169]}
{"index":530,"text":"The CAV\/PE-W consisted of 4 alternating cycles of cyclophosphamide : 500 mg\/m2 , doxorubicin : 30 mg\/m2 , and vincristine : 1 mg\/m2 ( day 1 ) and cisplatin : 50 mg\/m2 ( day 8) and etoposide : 75 mg\/m2 ( days 8 and 9 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","vincristine","cisplatin","etoposide"],"drug_indices_start":[50,81,110,146,180],"drug_indices_end":[66,92,121,155,189]}
{"index":531,"text":"Cyclophosphamide , methotrexate , 5-fluorouracil , and folinic acid ( CMFF ) as first line chemotherapy for treatment of advanced breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cyclophosphamide","methotrexate","5-fluorouracil","folinic acid"],"drug_indices_start":[0,19,34,55],"drug_indices_end":[16,31,48,67]}
{"index":532,"text":"High doses of rosuvastatin are superior to low doses of rosuvastatin plus fenofibrate or n-3 fatty acids in mixed dyslipidemia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rosuvastatin","rosuvastatin","fenofibrate"],"drug_indices_start":[14,56,74],"drug_indices_end":[26,68,85]}
{"index":533,"text":"Patients were divided randomly into 3 groups ( Group A : 0.5 % bupivacaine 5 mL , n = 12 ; Group B : 0.5 % bupivacaine 4.5 mL + 20 mg of triamcinolone 0.5 mL , n = 10 ; and Group C : 0.5 % bupivacaine 4 mL + 40 mg of triamcinolone 1 mL , n = 10 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","bupivacaine","triamcinolone","bupivacaine","triamcinolone"],"drug_indices_start":[63,107,137,189,217],"drug_indices_end":[74,118,150,200,230]}
{"index":534,"text":"Irinotecan and etoposide were combined using the ( d x 5)2 i.v . schedule for both drugs , in which irinotecan was given 2 h before or 2 h after the administration of etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Irinotecan","etoposide","irinotecan","etoposide"],"drug_indices_start":[0,15,100,167],"drug_indices_end":[10,24,110,176]}
{"index":535,"text":"Combination of sofosbuvir , pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection : a systematic review and meta-analysis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sofosbuvir","pegylated-interferon","ribavirin"],"drug_indices_start":[15,28,53],"drug_indices_end":[25,48,62]}
{"index":536,"text":"Immunosuppressive protocol : preoperative : Cyclosporin + Azathioprine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cyclosporin","Azathioprine"],"drug_indices_start":[44,58],"drug_indices_end":[55,70]}
{"index":537,"text":"Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","interferon alfa"],"drug_indices_start":[41,65],"drug_indices_end":[50,80]}
{"index":538,"text":"All patients received chemotherapy regimens that included doxorubicin ( 6 ) or etoposide ( 1 ) , and six were treated with infradiaphragmatic irradiation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[58,79],"drug_indices_end":[69,88]}
{"index":539,"text":"Of 1490 articles identified , we included 3 papers and 1 abstract with patients on aspirin and\/or NSAIDs , 1 paper on warfarin , 2 abstracts on clopidogrel , and 2 papers on clopidogrel plus aspirin and\/or NSAIDs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","warfarin","clopidogrel","clopidogrel","aspirin"],"drug_indices_start":[83,118,144,174,191],"drug_indices_end":[90,126,155,185,198]}
{"index":540,"text":"Topoisomerase IIalpha mRNA expression levels did not reflect sensitivity to doxorubicin or etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[76,91],"drug_indices_end":[87,100]}
{"index":541,"text":"We observed that efavirenz and etravirine induce metabolism of co-administered drugs by binding to a unique position in the active site of CYP3A4 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["efavirenz","etravirine"],"drug_indices_start":[17,31],"drug_indices_end":[26,41]}
{"index":542,"text":"First , we searched for the most synergistic combination of KPT-8602 with dexamethasone , vincristine , or doxorubicin","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["KPT-8602","dexamethasone","vincristine","doxorubicin"],"drug_indices_start":[60,74,90,107],"drug_indices_end":[68,87,101,118]}
{"index":543,"text":"In Thailand , artesunate and artemether are the mainly used antimalarials for treatment of severe or multidrug resistant falciparum malaria .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artesunate","artemether"],"drug_indices_start":[14,29],"drug_indices_end":[24,39]}
{"index":544,"text":"Epidural analgesia during labor--0.5 % lidocaine with fentanyl vs. 0.08 % ropivacaine with fentanyl .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lidocaine","fentanyl","ropivacaine","fentanyl"],"drug_indices_start":[39,54,74,91],"drug_indices_end":[48,62,85,99]}
{"index":545,"text":"Inhibition of Boyden Chamber migration of MNL 's in a MNL-lymphocyte mixture was achieved after 1\/2 hr incubation by 10(-3 ) and 10(-4 ) mol\/L. concentrations of chloroquine ( maximum inhibition 63 % + \/- 2.8 ) , dexamethasone ( 58 % + \/- 8.6 ) , 6-mercaptopurine ( 62 % + \/- 4.2 ) , methotrexate ( 66 % + \/- 6.4 ) , and vinblastine ( 100 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","dexamethasone","methotrexate","vinblastine"],"drug_indices_start":[162,213,284,321],"drug_indices_end":[173,226,296,332]}
{"index":547,"text":"Adding sulbactam to piperacillin resulted in increased susceptibility rates among piperacillin-resistant P. aeruginosa ( 53 - 57 % in either 2:1 or 4:1 ratios ) and A. baumannii ( 38 - 46 % in either 2:1 ratio or a fixed 8 mg\/L concentration of sulbactam ) isolates .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sulbactam","piperacillin","sulbactam"],"drug_indices_start":[7,20,245],"drug_indices_end":[16,32,254]}
{"index":548,"text":"Senescence can be efficiently induced in cultured cells by DNA-damaging drugs , including doxorubicin ( DOX ) , cisplatin and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","cisplatin","etoposide"],"drug_indices_start":[90,112,126],"drug_indices_end":[101,121,135]}
{"index":549,"text":"Preoperative treatment was 5 fractions radiation therapy ( 25 Gy to involved mesorectum , 20 Gy to elective nodes ) , followed by 4 cycles of FOLFOX [ 5-fluorouracil , oxaliplatin , leucovorin ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","leucovorin","5-fluorouracil"],"drug_indices_start":[151,168,182],"drug_indices_end":[165,179,192]}
{"index":550,"text":"The cost-effectiveness of dapagliflozin versus sulfonylurea as an add-on to metformin in the treatment of Type 2 diabetes mellitus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dapagliflozin","sulfonylurea","metformin"],"drug_indices_start":[26,47,76],"drug_indices_end":[39,59,85]}
{"index":551,"text":"The mean reduction of night time points was statistically lower than that of day time points for latanoprost ( P = 0.031 ) , timolol ( P = 0.032 ) , and brimonidine ( P = 0.050 ) , but not for dorzolamide ( P = 0.60 ) , bimatoprost ( P = 0.057 ) , travoprost ( P = 0.064 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["latanoprost","timolol","brimonidine","dorzolamide","bimatoprost","travoprost"],"drug_indices_start":[97,125,153,193,220,248],"drug_indices_end":[108,132,164,204,231,258]}
{"index":552,"text":"Moreover , the beneficial effects of dronedarone , amiodarone analogues , against Trypanosoma cruzi and Leishmania mexicana have recently been demonstrated and such treatment regimens resulted in lower side effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dronedarone","amiodarone"],"drug_indices_start":[37,51],"drug_indices_end":[48,61]}
{"index":553,"text":"This study aimed to investigate the efficacy and safety of iguratimod ( T-614 ) in combination with methotrexate ( MTX ) for active rheumatoid arthritis ( RA ) patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["iguratimod","methotrexate"],"drug_indices_start":[59,100],"drug_indices_end":[69,112]}
{"index":555,"text":"Irinotecan tended to result in more gastrointestinal tract reactions than oxaliplatin did , but the myelosuppression and neurotoxicity were more frequent in oxaliplatin regimen than irinotecan regimen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Irinotecan","oxaliplatin","oxaliplatin","irinotecan"],"drug_indices_start":[0,74,157,182],"drug_indices_end":[10,85,168,192]}
{"index":556,"text":"[ Intraoperative anaphylactic shock induced by methylergometrine and oxytocin ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methylergometrine","oxytocin"],"drug_indices_start":[47,69],"drug_indices_end":[64,77]}
{"index":557,"text":"Overexpression of MK in wild type neuroblastoma cells leads to acquired drug resistance to doxorubicin and to the related drug etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[91,127],"drug_indices_end":[102,136]}
{"index":558,"text":"The only approved second-line therapies for patients without targetable oncogenic drivers are docetaxel , gemcitabine , pemetrexed , and erlotinib and for patients with target-specific oncogenes afatinib , osimertinib , crizotinib , alectinib , and ceritinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","gemcitabine","pemetrexed","erlotinib","afatinib","osimertinib","crizotinib","alectinib","ceritinib"],"drug_indices_start":[94,106,120,137,195,206,220,233,249],"drug_indices_end":[103,117,130,146,203,217,230,242,258]}
{"index":559,"text":"an increase in serious adverse events with both regular formoterol and regular salmeterol in chronic asthma has been demonstrated in comparison with placebo in previous Cochrane reviews .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["formoterol","salmeterol"],"drug_indices_start":[56,79],"drug_indices_end":[66,89]}
{"index":560,"text":"[ An elderly patient with myelodysplastic syndrome successfully treated with combination of granulocyte-colony stimulating factor and continuous-drip infusion of low-dose cytarabine and etoposide ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cytarabine","etoposide"],"drug_indices_start":[171,186],"drug_indices_end":[181,195]}
{"index":562,"text":"The results suggested that irinotecan , 5-FU and leucovorin combination chemotherapy in a biweekly schedule is a practical and tolerable treatment option in patients with advanced colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","5-FU","leucovorin"],"drug_indices_start":[27,40,49],"drug_indices_end":[37,44,59]}
{"index":564,"text":"Cytotoxic monotherapy was the most frequently prescribed regimen ( N = 60 , 46 % ) in 2L , followed by combination therapies ( N = 45 , 35 % ) , pembrolizumab monotherapy ( N = 19 , 15 % ) , and bevacizumab monotherapy ( N = 6 , 5 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pembrolizumab","bevacizumab"],"drug_indices_start":[145,195],"drug_indices_end":[158,206]}
{"index":565,"text":"Terlipressin administration in rats pre-treated with octreotide further decreased portal pressure , portal tributary blood flow and increased hepatocollateral vascular resistance ; terlipressin increased arterial pressure and further decreased cardiac index .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Terlipressin","octreotide","terlipressin"],"drug_indices_start":[0,53,181],"drug_indices_end":[12,63,193]}
{"index":566,"text":"Results confirmed the antidepressant action of alprazolam and imipramine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alprazolam","imipramine"],"drug_indices_start":[47,62],"drug_indices_end":[57,72]}
{"index":567,"text":"Cell viability of two human hepatoma cell lines ( Huh7 and Hep-G2 ) was quantitatively investigated under the treatment of two drugs ( doxorubicin and etoposide ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[135,151],"drug_indices_end":[146,160]}
{"index":568,"text":"MIF , TRH , and its analog PR-546 , the paraopioid RP , leuenkephalin , dalargin , the ACTH analogue Semax , tafcin , thymosine , interleukin-1 , vasopressin , oxytocin , bradykinin , defencin , and some proline-containing oligopeptides , such as Pro-Gly , Gly-Pro , Trp-Pro , Pro-Gly-Pro , Gly-Pro-Gly-Gly were studied .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vasopressin","oxytocin","bradykinin"],"drug_indices_start":[146,160,171],"drug_indices_end":[157,168,181]}
{"index":569,"text":"In both cohorts , more than 40 % of patients discontinued their index drugs ( 46.4 % pazopanib and 44.1 % sunitinib , P = 0.732 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pazopanib","sunitinib"],"drug_indices_start":[85,106],"drug_indices_end":[94,115]}
{"index":570,"text":"The patients were heavily pretreated with anthracycline ( 100 % ) , taxane ( paclitaxel or docetaxel ) ( 100 % ) , capecitabine ( 100 % ) , vinorelbine ( 71 % ) , and mitomycin ( 69 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pretreated","paclitaxel","docetaxel","capecitabine","vinorelbine","mitomycin"],"drug_indices_start":[26,77,91,115,140,167],"drug_indices_end":[36,87,100,127,151,176]}
{"index":571,"text":"Therapy includes debridement of necrotic bone and loculated purulence combined with amphotericin B and possibly 5-fluorocytosine or rifampin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphotericin","rifampin"],"drug_indices_start":[84,132],"drug_indices_end":[96,140]}
{"index":572,"text":"Docetaxel and cisplatin were given at 75 mg\/m(2 ) , while capecitabine was initially given at 500 mg\/m(2 ) twice a day and subsequently escalated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Docetaxel","cisplatin","capecitabine"],"drug_indices_start":[0,14,58],"drug_indices_end":[9,23,70]}
{"index":573,"text":"A colorectal cancer cell line ( LOVO cell ) treated by curcumin combined with irinotecan in different ways respectively was used as our comparative model .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","irinotecan"],"drug_indices_start":[55,78],"drug_indices_end":[63,88]}
{"index":574,"text":"The use of ceftriaxone plus doxycycline as an initial empiric therapy for patients hospitalized with CAP appears safe and effective , and its potential superiority should be evaluated prospectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ceftriaxone","doxycycline","plus"],"drug_indices_start":[11,23,28],"drug_indices_end":[22,27,39]}
{"index":575,"text":"Metformin ( 50 mg\/kg\/day ) , genistein ( 20 mg\/kg\/day ) and combination of genistein and metformin was administered in alloxan-induced diabetic rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Metformin","genistein","genistein","metformin"],"drug_indices_start":[0,29,75,89],"drug_indices_end":[9,38,84,98]}
{"index":576,"text":"CYP3A5 ( intron 3 ) and MDR1 ( exons 12 , 21 , 26 ) genotypes were correlated to the adjusted trough concentrations and dose requirements for both sirolimus and tacrolimus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sirolimus","tacrolimus"],"drug_indices_start":[147,161],"drug_indices_end":[156,171]}
{"index":577,"text":"Here we report the results of a multicenter retrospective trial evaluating ASCT in patients with transformed lymphoma using the Z-BEAM conditioning regimen , which combines yttrium-90-labeled ibritumomab tiuxetan ( Zevalin ) with high-dose BEAM ( carmustine , etoposide , cytarabine , melphalan ) chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ibritumomab tiuxetan","carmustine","etoposide","cytarabine","melphalan"],"drug_indices_start":[192,247,260,272,285],"drug_indices_end":[212,257,269,282,294]}
{"index":578,"text":"Palbociclib is a selective cyclin-dependent kinase ( CDK ) 4\/6 inhibitor used in combination with aromatase inhibitors or fulvestrant for patients with hormone receptor-positive ( HR+ ) human epidermal growth factor receptor 2 (HER2)-negative advanced\/metastatic breast cancer ( ABC\/MBC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Palbociclib","fulvestrant"],"drug_indices_start":[0,122],"drug_indices_end":[11,133]}
{"index":579,"text":"Triplet schedule of weekly 5-fluorouracil and alternating irinotecan or oxaliplatin in advanced colorectal cancer : a dose-finding and phase II study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil","irinotecan","oxaliplatin"],"drug_indices_start":[27,58,72],"drug_indices_end":[41,68,83]}
{"index":580,"text":"After larvae were infected with S. aureus , larval survival was enhanced by administering the antistaphylococcal antibiotics daptomycin or vancomycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["daptomycin","vancomycin"],"drug_indices_start":[125,139],"drug_indices_end":[135,149]}
{"index":581,"text":"In terms of progression-free survival ( PFS ) , axitinib was superior compared with placebo ( HR = 0.25 , 95 % CrI : 0.17 - 0.38 ) , sorafenib ( HR = 0.46 , 95 % CrI : 0.32 - 0.68 ) and pazopanib ( HR = 0.47 , 95 % CrI : 0.26 - 0.85 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["axitinib","sorafenib","pazopanib"],"drug_indices_start":[48,133,186],"drug_indices_end":[56,142,195]}
{"index":582,"text":"Concomitant and sequential treatment with paclitaxel and gemcitabine had no significant difference in terms of PFS .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","gemcitabine"],"drug_indices_start":[42,57],"drug_indices_end":[52,68]}
{"index":583,"text":"Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer : A Phase 3 Randomized Clinical Trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Margetuximab","Trastuzumab"],"drug_indices_start":[12,28],"drug_indices_end":[24,39]}
{"index":584,"text":"She was treated with a combination of four cycles of cyclophosphamide , hydroxydaunorubicin , vincristine , and prednisolone ( CHOP ) regimen followed by local radiotherapy ( 36 Gray\/20 fractions\/4 weeks ) by three-dimensional conformal technique .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","vincristine","prednisolone"],"drug_indices_start":[53,94,112],"drug_indices_end":[69,105,124]}
{"index":585,"text":"We compared such treatment with docetaxel plus prednisone in men with this disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","prednisone"],"drug_indices_start":[32,47],"drug_indices_end":[41,57]}
{"index":586,"text":"Magnocellular neurons of the hypothalamo-neurophypophysial system synthesize either vasopressin or oxytocin ; water deprivation and chronic saline ingestion are potent stimuli for the expression of both of the genes encoding these neuropeptides .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vasopressin","oxytocin"],"drug_indices_start":[84,99],"drug_indices_end":[95,107]}
{"index":587,"text":"Combination chemotherapy has been established to have superior response rates and progression-free survival and -- in some instances , for fluorouracil and irinotecan combinations -- improved overall survival compared to fluorouracil alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","irinotecan","fluorouracil"],"drug_indices_start":[139,156,221],"drug_indices_end":[151,166,233]}
{"index":588,"text":"Phase IV study of bevacizumab in combination with infusional fluorouracil , leucovorin and irinotecan ( FOLFIRI ) in first-line metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","fluorouracil","leucovorin","irinotecan"],"drug_indices_start":[18,61,76,91],"drug_indices_end":[29,73,86,101]}
{"index":589,"text":"In addition , multidrug resistance of Hep-2-CSCs to vincristine , etoposide and doxorubicin was greatly improved after the cells were transfected with microRNA-125a mimics .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","etoposide","doxorubicin"],"drug_indices_start":[52,66,80],"drug_indices_end":[63,75,91]}
{"index":590,"text":"Nine patients received a combination of cisplatin and etoposide ( EP ) , 5 had cyclophosphamide , doxorubicin and vincristine , 1 had cyclophosphamide , etoposide and vincristine and 1 had monotherapy with oral etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","etoposide","cyclophosphamide","doxorubicin","vincristine","cyclophosphamide","etoposide","vincristine","etoposide"],"drug_indices_start":[40,54,79,98,114,134,153,167,211],"drug_indices_end":[49,63,95,109,125,150,162,178,220]}
{"index":591,"text":"Tetracycline ( TC ) and chlortetracycline ( CTC ) are used extensively for growth promotion and therapeutic purposes in livestock production .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Tetracycline","chlortetracycline"],"drug_indices_start":[0,24],"drug_indices_end":[12,41]}
{"index":592,"text":"Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nalidixic acid","metronidazole","metronidazole"],"drug_indices_start":[29,48,67],"drug_indices_end":[43,61,80]}
{"index":593,"text":"The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","primidone"],"drug_indices_start":[85,101],"drug_indices_end":[96,110]}
{"index":594,"text":"In vitro sensitivity of HT29 human colon cancer cells to doxorubicin ( DXR ) , vincristine ( VCR ) , etoposide ( VP16 ) , cisplatin ( CDDP ) , melphalan ( L-PAM ) and 5-fluorouracil ( 5FU ) was markedly reduced when cell-culture density increased .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","vincristine","etoposide","cisplatin","melphalan"],"drug_indices_start":[57,79,101,122,143],"drug_indices_end":[68,90,110,131,152]}
{"index":595,"text":"ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","fluorouracil"],"drug_indices_start":[113,129],"drug_indices_end":[124,141]}
{"index":596,"text":"7 patients ( 53 % ) receiving pamidronate and thalidomide therapy demonstrated good response involving at least 25 % reduction of monoclonal protein levels in comparison with baseline .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pamidronate","thalidomide"],"drug_indices_start":[30,46],"drug_indices_end":[41,57]}
{"index":597,"text":"Growth inhibition was measured by 3H-thymidine incorporation assays for doxorubicin hydrochloride ( ADM ) , mitomycin C ( MMC ) , cisplatin ( CDDP ) , and etoposide ( VP-16 ) , and by Alamar Blue assay for ( AB assay ) 5-fluorouracil ( 5-FU ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","mitomycin","cisplatin","etoposide"],"drug_indices_start":[72,108,130,155],"drug_indices_end":[83,117,139,164]}
{"index":598,"text":"A similar relapse rate was also obtained with a 6-month completely oral regimen including TMC207 , moxifloxacin and pyrazinamide but excluding both amikacin and ethionamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["TMC207","moxifloxacin","pyrazinamide","amikacin","ethionamide"],"drug_indices_start":[90,99,116,148,161],"drug_indices_end":[96,111,128,156,172]}
{"index":599,"text":"Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma : Safety , Tolerability , and Preliminary Evidence of Antitumor Activity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Propranolol","Pembrolizumab"],"drug_indices_start":[38,54],"drug_indices_end":[49,67]}
{"index":600,"text":"Iohexol and iodixanol resulted in similarly marked increases in levels of inflammation and oxidative stress .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Iohexol","iodixanol"],"drug_indices_start":[0,12],"drug_indices_end":[7,21]}
{"index":601,"text":"Sequential exposure of vinorelbine preceding paclitaxel or prolonged exposure to both agents concurrently needs to be tested clinically to determine whether the antitumor activity of this combination can be enhanced .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinorelbine","paclitaxel"],"drug_indices_start":[23,45],"drug_indices_end":[34,55]}
{"index":602,"text":"On the other hand we observed that topoisomerase II ( Top2 ) poisons ( doxorubicin and etoposide ) did not affect 1 day post fertilization embryo viability , however in cells isolated from Top2 drug treated embryos the formation of DNA cleavage complexes was observed by comet assay .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[71,87],"drug_indices_end":[82,96]}
{"index":603,"text":"Favorable Response of Metastatic Hepatocellular Carcinoma to Treatment with Trans-arterial Radioembolization Followed by Sorafenib and Nivolumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sorafenib","Nivolumab"],"drug_indices_start":[121,135],"drug_indices_end":[130,144]}
{"index":605,"text":"In addition to prolonged survival , these exploratory HRQoL results show that nivolumab maintains baseline HRQoL levels to provide long-term quality of survival benefit , compared with dacarbazine in patients with advanced melanoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","dacarbazine"],"drug_indices_start":[78,185],"drug_indices_end":[87,196]}
{"index":606,"text":"This phase 1 trial determined the safety , pharmacokinetics , and antitumor activity of LY3022855 in combination with durvalumab or tremelimumab in patients with advanced solid cancers who had received standard anti-cancer treatments .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["LY3022855","durvalumab","tremelimumab"],"drug_indices_start":[88,118,132],"drug_indices_end":[97,128,144]}
{"index":607,"text":"Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vildagliptin","voglibose"],"drug_indices_start":[51,68],"drug_indices_end":[63,77]}
{"index":608,"text":"CD133 + cells ( CD133 is marker of CSC in some tumors ) isolated from NBL , osteosarcoma and Ewing sarcoma cell lines are resistant to cisplatin , carboplatin , etoposide and doxorubicin than the CD133- ones .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","carboplatin","etoposide","doxorubicin"],"drug_indices_start":[135,147,161,175],"drug_indices_end":[144,158,170,186]}
{"index":609,"text":"The epidermal growth factor receptor ( EGFR ) inhibitors , gefitinib , erlotinib and afatinib ; the anaplastic lymphoma kinase ( ALK ) inhibitor , crizotinib ; and the anti-vascular endothelial growth factor receptor monoclonal antibody , bevacizumab , are already providing improved survival for patients with NSCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","erlotinib","afatinib","crizotinib","bevacizumab"],"drug_indices_start":[59,71,85,147,239],"drug_indices_end":[68,80,93,157,250]}
{"index":610,"text":"Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paroxetine","fluvoxamine"],"drug_indices_start":[40,55],"drug_indices_end":[50,66]}
{"index":611,"text":"Phase 3 data support the use of sunitinib , bevacizumab plus interferon-\u03b1 and pazopanib for patients with low and intermediate risk of clear-cell renal cell carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","bevacizumab","pazopanib","interferon-\u03b1"],"drug_indices_start":[32,44,61,78],"drug_indices_end":[41,55,73,87]}
{"index":612,"text":"This study is designed to find out the efficacy and toxicity of the combination of oxaliplatin and gemcitabine in the treatment of advanced non-small cell lung cancer ( NSCLC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","gemcitabine"],"drug_indices_start":[83,99],"drug_indices_end":[94,110]}
{"index":613,"text":"All patients received 900 mg\/m2 bolus of cyclophosphamide intravenously daily for 3 consecutive days with a concurrent infusion of 150 mg\/m2 of paclitaxel over 72 h ( 50 mg\/m2\/d ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","paclitaxel"],"drug_indices_start":[41,144],"drug_indices_end":[57,154]}
{"index":614,"text":"Rituximab combined with a small dose of melphalan for a refractory follicular lymphoma patient .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Rituximab","melphalan"],"drug_indices_start":[0,40],"drug_indices_end":[9,49]}
{"index":615,"text":"In this study , the intrinsic anti-bacterial activity of mefloquine and azithromycin was assessed in comparison to sulphadoxine-pyrimethamine against bacterial pathogens with clinical importance in pregnancy in a standard microdilution assay .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","azithromycin"],"drug_indices_start":[57,72],"drug_indices_end":[67,84]}
{"index":616,"text":"Pirfenidone has a beneficial effect on morphological changes in anti-GBM GN comparable with candesartan","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Pirfenidone","candesartan"],"drug_indices_start":[0,92],"drug_indices_end":[11,103]}
{"index":617,"text":"Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients : a randomized safety and efficacy study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Difluprednate","prednisolone"],"drug_indices_start":[0,21],"drug_indices_end":[13,33]}
{"index":618,"text":"Accumulated doses of cyclophosphamide , procarbazine , doxorubicin , mitoxantrone , and etoposide were 18,300 mg , 3000 mg , 580 mg , 100 mg , and 4150 mg , respectively , which had been administered for the treatment of NHL .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","procarbazine","doxorubicin","mitoxantrone","etoposide"],"drug_indices_start":[21,40,55,69,88],"drug_indices_end":[37,52,66,81,97]}
{"index":619,"text":"In newly diagnosed patients with MCL ineligible for intensive therapy and ASCT , the standard-of-care has generally been R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine , and prednisone ) , followed by rituximab , maintenance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cyclophosphamide","doxorubicin","vincristine","prednisone","rituximab"],"drug_indices_start":[130,142,161,175,193,220],"drug_indices_end":[139,158,172,186,203,229]}
{"index":620,"text":"Here , we analyze the effects of the broad-spectrum HDAC inhibitors ( HDACi ) panobinostat and vorinostat on the transcriptional regulation of autophagy with respect to autophagy transcription factor activity ( Transcription factor EB-TFEB , forkhead boxO-FOXO ) and autophagic flux in neuroblastoma cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["panobinostat","vorinostat"],"drug_indices_start":[78,95],"drug_indices_end":[90,105]}
{"index":621,"text":"The postischemic decrease in total intensity and frequency index in EEG recovered rapidly when nitrendipine was pretreated , whereas the recovery of EEG parameters was not obtained by the nicardipine pretreatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nitrendipine","nicardipine"],"drug_indices_start":[95,188],"drug_indices_end":[107,199]}
{"index":622,"text":"The results indicate that BU and IPSA behave additively with verapamil and carbamazepine , which may be due to a common action on the same subtype of calcium channels .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["BU","IPSA","verapamil","carbamazepine"],"drug_indices_start":[26,33,61,75],"drug_indices_end":[28,37,70,88]}
{"index":623,"text":"The combination of docetaxel and trastuzumab is well tolerated and has clinically meaningful antitumor activity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","trastuzumab"],"drug_indices_start":[19,33],"drug_indices_end":[28,44]}
{"index":624,"text":"Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["insulin-like growth factor-I","prednisolone","ursodeoxycholic acid"],"drug_indices_start":[25,59,75],"drug_indices_end":[53,71,95]}
{"index":625,"text":"The AV3V-lesioned group of animals were characterized by an inability to excrete the excess sodium load and by a failure to increase secretion of both oxytocin and vasopressin into the general circulation in response to the salt-stimulus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxytocin","vasopressin"],"drug_indices_start":[151,164],"drug_indices_end":[159,175]}
{"index":626,"text":"Patients received BBFC ( n = 193 ) , brinzolamide 1 % ( n = 192 ) , or brimonidine 0.2 % ( n = 175 ) BID .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["brinzolamide","brimonidine"],"drug_indices_start":[37,71],"drug_indices_end":[49,82]}
{"index":627,"text":"Artemisinin ( ART ) is a sesquiterpene lactone extracted from Chinese herb qinghao , and artemether ( ARM ) , artesunate ( ARS ) and dihydroartemisinin ( DHA ) were synthesized derivatives of artemisinin , which also have anti-malarial and anti-cancer effects such as artemisinin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Artemisinin","artemether","artesunate","dihydroartemisinin","artemisinin","artemisinin"],"drug_indices_start":[0,89,110,133,192,268],"drug_indices_end":[11,99,120,151,203,279]}
{"index":628,"text":"Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","trabectedin"],"drug_indices_start":[95,111],"drug_indices_end":[106,122]}
{"index":629,"text":"Conversely , down-regulation of cyclin E1 gene expression or inhibition of cyclin E1 by the cyclin-dependent kinase ( CDK ) inhibitors dinaciclib ( DIN ) or flavopiridol sensitized HCC cells to regorafenib and sorafenib by inducing apoptosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dinaciclib","flavopiridol","regorafenib","sorafenib"],"drug_indices_start":[135,157,194,210],"drug_indices_end":[145,169,205,219]}
{"index":630,"text":"Levofloxacin hemihydrate ( LEV ) and ambroxol HCl ( AMB ) are available for the treatment of upper and lower respiratory tract infections .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Levofloxacin","ambroxol"],"drug_indices_start":[0,37],"drug_indices_end":[12,45]}
{"index":631,"text":"Cytarabine and etoposide intensification exceeded the acceptable toxic death rate of 10 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cytarabine","etoposide"],"drug_indices_start":[0,15],"drug_indices_end":[10,24]}
{"index":632,"text":"After initiating warfarin plus lenvatinib , INR assays are necessary .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["warfarin","lenvatinib"],"drug_indices_start":[17,31],"drug_indices_end":[25,41]}
{"index":633,"text":"Treatment with the DNA topoisomerase inhibitors etoposide , doxorubicin , and camptothecin , and with the alkylating agents cisplatin and melphalan , caused peroxide accumulation and apoptosis in U-937 human promonocytic cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin","cisplatin","melphalan"],"drug_indices_start":[48,60,124,138],"drug_indices_end":[57,71,133,147]}
{"index":634,"text":"We retrospectively analyzed 76 patients with LD SCLC who received combination cisplatin or carboplatin of etoposide or irinotecan .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","carboplatin","etoposide","irinotecan"],"drug_indices_start":[78,91,106,119],"drug_indices_end":[87,102,115,129]}
{"index":635,"text":"MCF-7 cells which expressed a constitutively-activated Akt-1 gene [ \u2206Akt-1(CA ) ] were more resistant to doxorubicin , etoposide and 4-OH-tamoxifen ( 4HT ) than cells lacking \u2206Akt-1(CA ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide","4-OH-tamoxifen"],"drug_indices_start":[105,119,133],"drug_indices_end":[116,128,147]}
{"index":636,"text":"that , in response to mitomycin C and doxorubicin , human hepatocellular carcinoma cells generate conflicting signals , mediated by cyclin E and p21WAF1\/CIP1 , which respectively accelerates and represses cell cycle transition .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitomycin","doxorubicin"],"drug_indices_start":[22,38],"drug_indices_end":[31,49]}
{"index":637,"text":"In the last years , the main topoisomerase I inhibitors ( TP1-I ) ( i.e. topotecan and irinotecan ) have been used in combination chemotherapy in non-small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["topotecan","irinotecan"],"drug_indices_start":[73,87],"drug_indices_end":[82,97]}
{"index":638,"text":"Merimepodib ( MMPD ) is an orally administered , inosine monophosphate dehydrogenase inhibitor that has shown antiviral activity in nonresponders with chronic hepatitis C ( CHC ) when combined with pegylated interferon alfa 2a ( Peg-IFN-alfa-2a ) and ribavirin ( RBV ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["inosine","interferon alfa","ribavirin","Merimepodib"],"drug_indices_start":[0,49,208,251],"drug_indices_end":[11,56,223,260]}
{"index":639,"text":"Of the antibacterial agents examined , only carbenicillin and , to a lesser extent , gentamicin were active against the bacteria usually encountered whilst still permitting normal protoplast metabolism and regeneration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbenicillin","gentamicin"],"drug_indices_start":[44,85],"drug_indices_end":[57,95]}
{"index":640,"text":"Chemosensitization is one of the anti-tumor effects of E1A , increasing in vitro and in vivo sensitization of anti-cancer drugs , including cisplatin , gemcitabine , etoposide , doxorubicin , paclitaxel , and tumor necrosis factor-related apoptosis-inducing ligand and histone deacetylase inhibitors in different types of cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","gemcitabine","etoposide","doxorubicin","paclitaxel"],"drug_indices_start":[140,152,166,178,192],"drug_indices_end":[149,163,175,189,202]}
{"index":641,"text":"A strong correlation was only found between the level of MRP3 expression and the IC(50 ) values of etoposide , doxorubicin and pirarubicin ( r = 0.86 - 0.98 , P<0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin","pirarubicin"],"drug_indices_start":[99,111,127],"drug_indices_end":[108,122,138]}
{"index":642,"text":"In addition to the typical cross-resistance to doxorubicin , daunorubicin , vincristine and etoposide , we observed a significant resistance of the C6,5 x 10(-7 ) Dox cell line to irradiation , which can not be explained by Pgp-expression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","daunorubicin","vincristine","etoposide"],"drug_indices_start":[47,61,76,92],"drug_indices_end":[58,73,87,101]}
{"index":643,"text":"[ Effects of endostatin and doxycycline on microcirculation patterns in melanoma and their relevant molecular mechanisms ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["endostatin","doxycycline"],"drug_indices_start":[13,28],"drug_indices_end":[23,39]}
{"index":644,"text":"It is likely that optimal application of these agents will involve combinations of inhibitors and combinations of inhibitors and chemotherapy , potentially with a mammalian target of rapamycin inhibitor such as everolimus or temsirolimus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rapamycin","everolimus","temsirolimus"],"drug_indices_start":[183,211,225],"drug_indices_end":[192,221,237]}
{"index":645,"text":"Subsequent investigation of therapeutic responsiveness upon treatment with the current systemic gold standard EDP-M ( etoposide , doxorubicin , cisplatin and mitotane ) demonstrated maintenance of the clinically observed drug resistance for MUC-1 exclusively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin","cisplatin","mitotane"],"drug_indices_start":[118,130,144,158],"drug_indices_end":[127,141,153,166]}
{"index":646,"text":"Oxaliplatin is active in NSCLC , offers advantage in terms of toxicity , and shows synergism with gemcitabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Oxaliplatin","gemcitabine"],"drug_indices_start":[0,98],"drug_indices_end":[11,109]}
{"index":647,"text":"A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel , abiraterone acetate , enzalutamide , cabozantinib , carboplatin or cabazitaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","abiraterone","enzalutamide","cabozantinib","carboplatin","cabazitaxel"],"drug_indices_start":[105,117,139,154,169,184],"drug_indices_end":[114,128,151,166,180,195]}
{"index":648,"text":"Pharmacological interventions with a proton pump inhibitor ( PPI ) , H2 receptor antagonist ( H2RA ) , antacid , bismuth and sucralfate may have effects on both the prevention and treatment of upper gastrointestinal bleeding in infants .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bismuth","sucralfate"],"drug_indices_start":[113,125],"drug_indices_end":[120,135]}
{"index":649,"text":"Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Doxorubicin","lapatinib"],"drug_indices_start":[0,16],"drug_indices_end":[11,25]}
{"index":650,"text":"The HIV protease inhibitor ritonavir , a strong CYP3A4 inhibitor , decreased first-pass metabolism of orally administered docetaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ritonavir","docetaxel"],"drug_indices_start":[27,122],"drug_indices_end":[36,131]}
{"index":651,"text":"Ramucirumab plus osimertinib demonstrated encouraging safety and antitumor activity in T790M-positive EGFR-mutant NSCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ramucirumab","osimertinib"],"drug_indices_start":[0,17],"drug_indices_end":[11,28]}
{"index":652,"text":"The patient was complicated with hemophagocytic lymphohistiocytosis ( HLH ) and invasive aspergillosis ( IPA ) after re-induction treatment with FLAG-IDA following etoposide , cytarabine , and mitoxantrone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","cytarabine","mitoxantrone"],"drug_indices_start":[164,176,193],"drug_indices_end":[173,186,205]}
{"index":653,"text":"On the other hand , cyclosporine and tacrolimus have a different impact on cardiovascular risk factors with tacrolimus having a better profile on arterial tension and lipid metabolism and cyclosporine on glucose metabolism .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine","tacrolimus","tacrolimus","cyclosporine"],"drug_indices_start":[20,37,108,188],"drug_indices_end":[32,47,118,200]}
{"index":654,"text":"Isoniazid , streptomycin , rifampin , and ethambutol were each tested at 3 concentrations by the radiometric method and the reference ( agar dilution ) method .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Isoniazid","streptomycin","rifampin","ethambutol"],"drug_indices_start":[0,12,27,42],"drug_indices_end":[9,24,35,52]}
{"index":655,"text":"Pretreatment of the rats with methamphetamine ( MAP ) for 8 days prior to chronic haloperidol significantly enhanced the DOPAC and HVA increase produced by the challenge with haloperidol in both brain areas .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methamphetamine","haloperidol","haloperidol"],"drug_indices_start":[30,82,175],"drug_indices_end":[45,93,186]}
{"index":656,"text":"The patients participated in three clinical trials that combined tumor vaccines with potential Treg-depleting agents : low-dose cyclophosphamide , anti-CD25 monoclonal antibody daclizumab , and the IL-2\/diphtheria toxin fusion protein denileukin diftitox .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","daclizumab","denileukin diftitox"],"drug_indices_start":[128,177,235],"drug_indices_end":[144,187,254]}
{"index":657,"text":"The quantity and composition of bacterial communities were altered by treatment with the five-antibiotic cocktail and by treatment with vancomycin and ampicillin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vancomycin","ampicillin"],"drug_indices_start":[136,151],"drug_indices_end":[146,161]}
{"index":658,"text":"Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH ( etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ) chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","prednisone","vincristine","cyclophosphamide","doxorubicin"],"drug_indices_start":[78,90,103,117,140],"drug_indices_end":[87,100,114,133,151]}
{"index":659,"text":"Tremelimumab plus gemcitabine demonstrated a safety and tolerability profile , warranting further study in patients with metastatic pancreatic cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Tremelimumab","gemcitabine"],"drug_indices_start":[0,18],"drug_indices_end":[12,29]}
{"index":660,"text":"The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone ( AZQ ) , etoposide and doxorubicin ( DOX ) using a [ (35)S ] methione uptake assay .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin"],"drug_indices_start":[174,188],"drug_indices_end":[183,199]}
{"index":661,"text":"Longer progression-free survival ( PFS ) and overall survival ( OS ) were observed with T-DM1 compared with capecitabine plus lapatinib in all biomarker subgroups .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","lapatinib"],"drug_indices_start":[108,126],"drug_indices_end":[120,135]}
{"index":662,"text":"Pharmacokinetics , Safety , and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer : Phase Ib Study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Apalutamide","Abiraterone","Prednisone"],"drug_indices_start":[52,69,94],"drug_indices_end":[63,80,104]}
{"index":663,"text":"Combined treatment with nintedanib ( 200 mg\/bid ) plus letrozole ( 2.5 mg\/day ) effectively suppressed FGFR1 and aromatase activity , and these respective doses can be used as starting doses in any subsequent trials .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nintedanib","letrozole"],"drug_indices_start":[24,55],"drug_indices_end":[34,64]}
{"index":664,"text":"A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","vinorelbine"],"drug_indices_start":[43,59],"drug_indices_end":[54,70]}
{"index":665,"text":"Patients ( n = 28 ) with metastatic solid tumors were randomized to receive pretreatment with Dex or GM-CSF or no pretreatment prior to courses 1 or 2 of carboplatin and ifosfamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","ifosfamide","Dex","GM-CSF"],"drug_indices_start":[94,101,154,170],"drug_indices_end":[97,107,165,180]}
{"index":666,"text":"After a thyroidectomy , she was treated with intravenous methylprednisolone pulse therapy and oral prednisolone followed by tacrolimus therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methylprednisolone","prednisolone","tacrolimus"],"drug_indices_start":[57,99,124],"drug_indices_end":[75,111,134]}
{"index":667,"text":"The vinca alkaloid , vinorelbine , and the multi-targeted antifol , pemetrexed , were additive with imexon in both cell lines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinorelbine","pemetrexed","imexon"],"drug_indices_start":[21,68,100],"drug_indices_end":[32,78,106]}
{"index":668,"text":"Supine blood pressures ( group means ) were 171\/97 ( placebo ) , 147\/85 ( enalapril ) , 154\/84 ( atenolol ) and 144\/78 ( enalapril plus atenolol ) ( S.E.M. + \/- 2\/+\/- 1-ANOVA ) , and standing blood pressures were 170\/105 ( placebo ) , 146\/92 ( enalapril ) , 154\/92 ( atenolol ) and 147\/86 ( enalapril plus atenolol ) ( S.E.M. + \/- 3\/+\/- 1 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enalapril","atenolol","enalapril","atenolol","enalapril","atenolol","enalapril","atenolol"],"drug_indices_start":[74,97,121,136,244,267,291,306],"drug_indices_end":[83,105,130,144,253,275,300,314]}
{"index":669,"text":"To evaluate the toxicity and activity of infusional fluorouracil ( FU ) , folinic acid ( FA ) , and oxaliplatin , administered every 2 weeks in patients with metastatic gastric cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","folinic acid","oxaliplatin"],"drug_indices_start":[52,74,100],"drug_indices_end":[64,86,111]}
{"index":670,"text":"Bevacizumab in combination with interferon alfa is now approved for treatment-na\u00efve advanced renal cell carcinoma ( RCC ) in both the US and Europe .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","interferon alfa"],"drug_indices_start":[0,32],"drug_indices_end":[11,47]}
{"index":671,"text":"YM155 in combination with rituximab was tolerable with encouraging antitumor activity and durable responses in relapsed aggressive B-cell NHL patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["YM155","rituximab"],"drug_indices_start":[0,26],"drug_indices_end":[5,35]}
{"index":672,"text":"Both , droperidol and the new 5-HT3-antagonist ( e.g. dolasetron ) are effective drugs in the prevention of postoperative nausea and vomiting ( PONV ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["droperidol","dolasetron"],"drug_indices_start":[7,54],"drug_indices_end":[17,64]}
{"index":673,"text":"Use of doxycycline or azithromycin had little effect on the likelihood of removal of the IUD within 90 days of insertion ( OR 1.05 ; 95 % CI 0.68 - 1.63 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxycycline","azithromycin"],"drug_indices_start":[7,22],"drug_indices_end":[18,34]}
{"index":674,"text":"Similarly , a significant benefit in progression-free survival for carboplatin plus gemcitabine versus carboplatin monotherapy was seen in the Gynecologic Cancer InterGroup trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","gemcitabine","carboplatin"],"drug_indices_start":[67,84,103],"drug_indices_end":[78,95,114]}
{"index":675,"text":"We report a case series of 10 patients that were treated with betamethasone valerate foam ( 0.12 % ) in the morning and topical tazarotene cream ( 0.1 % ) in the evening for a total of 12 weeks or until plaques cleared .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["betamethasone","tazarotene"],"drug_indices_start":[62,128],"drug_indices_end":[75,138]}
{"index":676,"text":"Valsartan and sulfasalazine also reduced markers of oxidative stress after DSS administration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Valsartan","sulfasalazine"],"drug_indices_start":[0,14],"drug_indices_end":[9,27]}
{"index":677,"text":"Only two relapses have occurred in the cohort since withdrawal of Mitoxantrone , occurring in the two patients who had previously been treated with Glatiramer Acetate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mitoxantrone","Glatiramer"],"drug_indices_start":[66,148],"drug_indices_end":[78,158]}
{"index":678,"text":"Metronomic 5-fluorouracil , oxaliplatin and irinotecan in colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil","oxaliplatin","irinotecan"],"drug_indices_start":[11,28,44],"drug_indices_end":[25,39,54]}
{"index":679,"text":"Several epidemiological , clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs ( NSAIDs ) ( aspirin , naproxen , sulindac , celecoxib , and licofelone ) , statins and other natural agents-both individually , and in combinations .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","naproxen","sulindac","celecoxib","licofelone"],"drug_indices_start":[207,217,228,239,255],"drug_indices_end":[214,225,236,248,265]}
{"index":680,"text":"Lenalidomide is an approved medication for relapsed mantle cell lymphoma in patients who received at least two lines of therapy , including bortezomib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Lenalidomide","bortezomib"],"drug_indices_start":[0,140],"drug_indices_end":[12,150]}
{"index":681,"text":"Combination of mefloquine and praziquantel gave better curative effects than praziquantel or mefloquine given alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","praziquantel","praziquantel","mefloquine"],"drug_indices_start":[15,30,77,93],"drug_indices_end":[25,42,89,103]}
{"index":682,"text":"The aim of this study was to evaluate whether trastuzumab modifies the pharmacokinetics of epirubicin and its metabolites .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","epirubicin"],"drug_indices_start":[46,91],"drug_indices_end":[57,101]}
{"index":683,"text":"Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","cyclophosphamide","paclitaxel","trastuzumab"],"drug_indices_start":[27,43,72,99],"drug_indices_end":[38,59,82,110]}
{"index":684,"text":"Bupropion differentially alters the aversive , locomotor and rewarding properties of nicotine in CD-1 mice .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bupropion","nicotine"],"drug_indices_start":[0,85],"drug_indices_end":[9,93]}
{"index":685,"text":"We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin , clarithromycin , metronidazole , tetracycline and levofloxacin in Bangladesh .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amoxicillin","clarithromycin","metronidazole","tetracycline","levofloxacin"],"drug_indices_start":[86,100,117,133,150],"drug_indices_end":[97,114,130,145,162]}
{"index":686,"text":"With the exception of one Y. enterocolitica isolate which was resistant to tetracycline and streptomycin , the isolates were sensitive to the non-beta-lactam antibiotics .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tetracycline","streptomycin"],"drug_indices_start":[75,92],"drug_indices_end":[87,104]}
{"index":687,"text":"Meropenem ( 84.5 % ) and vancomycin ( 100 % ) remain the most effective antimicrobial agents against Gram negative and Gram positive bacteria , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Meropenem","vancomycin"],"drug_indices_start":[0,25],"drug_indices_end":[9,35]}
{"index":688,"text":"Troublesome coughing , as observed by the operator , was less frequent with glycopyrrolate ( control 51 % , atropine 42 % , glycopyrrolate 30 % ) , as was patient movement ( 40 % , 32 % , 19 % , respectively ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["glycopyrrolate","atropine","glycopyrrolate"],"drug_indices_start":[76,108,124],"drug_indices_end":[90,116,138]}
{"index":689,"text":"The first trial was a multicenter randomized phase III study of chemotherapy ( doxorubicin\/cyclophosphamide or paclitaxel ) + \/- trastuzumab , and the second was a multicenter phase II trial of vinorelbine + trastuzumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin\/cyclophosphamide","paclitaxel","trastuzumab","vinorelbine","trastuzumab"],"drug_indices_start":[79,111,129,194,208],"drug_indices_end":[107,121,140,205,219]}
{"index":690,"text":"Peginterferon alfa-2a ( 40KD ) plus ribavirin has given an overall sustained virological response of 18 % in F3\/F4 previous nonresponder US patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Peginterferon alfa-2a","ribavirin"],"drug_indices_start":[0,36],"drug_indices_end":[21,45]}
{"index":691,"text":"Simultaneous determination of pyrimethamine and mefloquine in human plasma by high-performance liquid chromatography with ultraviolet detection .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pyrimethamine","mefloquine"],"drug_indices_start":[30,48],"drug_indices_end":[43,58]}
{"index":692,"text":"We conducted a phase I and pharmacokinetic study with the erlotinib and celecoxib combination in patients with advanced premalignant lesions .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","celecoxib"],"drug_indices_start":[58,72],"drug_indices_end":[67,81]}
{"index":693,"text":"Out of 115 transplanted specimens 52 models were established of which 29 were characterized for response to docetaxel , cetuximab , methotrexate , carboplatin , 5-fluorouracil and everolimus .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","cetuximab","methotrexate","carboplatin","5-fluorouracil","everolimus"],"drug_indices_start":[108,120,132,147,161,180],"drug_indices_end":[117,129,144,158,175,190]}
{"index":694,"text":"Apart from progesterone , the enhancing effects of surfactants were better than those of non-surfactant MDR reversing agents such as verapamil , trifluoperazine and reserpine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","trifluoperazine","reserpine"],"drug_indices_start":[133,145,165],"drug_indices_end":[142,160,174]}
{"index":695,"text":"A549-Gem is cross-resistant to vincristine and etoposide , but not resistant to adriamycin , cisplatin , cytarabine and paclitaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","etoposide","cisplatin","cytarabine","paclitaxel"],"drug_indices_start":[31,47,93,105,120],"drug_indices_end":[42,56,102,115,130]}
{"index":696,"text":"[ Efficacy of combination therapy of lamivudine and adefovir dipivoxyl for patients with hepatitis B-induced decompensated liver cirrhosis ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lamivudine","adefovir"],"drug_indices_start":[37,52],"drug_indices_end":[47,60]}
{"index":697,"text":"The effervescent aspirin preparation is at least as effective as the combination of aspirin plus metoclopramide , but has fewer side effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","aspirin","metoclopramide"],"drug_indices_start":[17,84,97],"drug_indices_end":[24,91,111]}
{"index":698,"text":"Several agents are now available in this setting , including neratinib , tucatinib , ado-trastuzumab emtansine , and trastuzumab deruxtecan .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["neratinib","emtansine","trastuzumab deruxtecan"],"drug_indices_start":[61,101,117],"drug_indices_end":[70,110,139]}
{"index":699,"text":"This is an investigator-initiated , multicenter randomized controlled trial ( RCT ) designed to compare the combination treatment of adalimumab and methotrexate with adalimumab monotherapy in patients with psoriasis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["adalimumab","methotrexate","adalimumab"],"drug_indices_start":[133,148,166],"drug_indices_end":[143,160,176]}
{"index":700,"text":"These results provide compelling preclinical rationale indicating lapatinib to be a potentially efficacious chemotherapeutic combination partner for irinotecan in the treatment of gastrointestinal carcinomas .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","irinotecan"],"drug_indices_start":[66,149],"drug_indices_end":[75,159]}
{"index":702,"text":"The enhancement characteristics in different portions of the liver during dynamic sequential bolus computed tomography ( CT ) with iodinated contrast material ( DSBCT ) were prospectively evaluated in 75 patients by using iothalamate meglumine , iopamidol , and iohexol ( 25 patients received each agent ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["meglumine","iopamidol","iohexol"],"drug_indices_start":[234,246,262],"drug_indices_end":[243,255,269]}
{"index":704,"text":"The purpose of this study was to evaluate the efficacy of long-term use of bupropion sustained release ( SR ) , the nicotine patch , and the combination of these 2 treatments in patients who initially failed treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupropion","nicotine"],"drug_indices_start":[75,116],"drug_indices_end":[84,124]}
{"index":705,"text":"Clinical and microbiologic cure rates for NGU were somewhat low and there was no significant difference between azithromycin and doxycycline .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","doxycycline"],"drug_indices_start":[112,129],"drug_indices_end":[124,140]}
{"index":706,"text":"In the main study submitted for this application , a 2.4-month longer median overall survival time and a 30 % lower risk for death were observed for cabazitaxel , compared with mitoxantrone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cabazitaxel","mitoxantrone"],"drug_indices_start":[149,177],"drug_indices_end":[160,189]}
{"index":707,"text":"Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","actinomycin D","cyclophosphamide","etoposide","cisplatin"],"drug_indices_start":[27,41,62,101,116],"drug_indices_end":[38,54,78,110,125]}
{"index":708,"text":"He was asymptomatic half a year after the rituximab with cyclophosphamide , vincristine , doxorubicin , methotrexate\/ifosfamide , etoposide , and high-dose cytarabine protocol therapy ; the lymphoma is in remission .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cyclophosphamide","vincristine","doxorubicin","methotrexate\/ifosfamide","etoposide","cytarabine"],"drug_indices_start":[42,57,76,90,104,130,156],"drug_indices_end":[51,73,87,101,127,139,166]}
{"index":709,"text":"The RC0.1 and RC1 cells have high cross-resistance to CPT derivatives including SN-38 and topotecan , but are not cross-resistant to the non-top1 inhibitors etoposide , doxorubicin , and vincristine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["topotecan","etoposide","doxorubicin","vincristine"],"drug_indices_start":[90,157,169,187],"drug_indices_end":[99,166,180,198]}
{"index":710,"text":"To evaluate empiric nifuratel , amoxicillin , and bismuth triple therapy for H. pylori gastritis in childhood .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nifuratel","amoxicillin","bismuth"],"drug_indices_start":[20,32,50],"drug_indices_end":[29,43,57]}
{"index":711,"text":"The patient was treated in July 1998 with anthracycline , etoposide , and behenoyl cytarabine chemotherapy for AML ( French-American-British classification , M2 ; World Health Organization classification , AML with maturation ) and achieved complete remission .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anthracycline","etoposide","behenoyl cytarabine"],"drug_indices_start":[42,58,74],"drug_indices_end":[55,67,93]}
{"index":712,"text":"The risk increased when ASA was combined with clopidogrel , compared with aspirin alone ( OR , 1.86 ; 95 % CI , 1.49 - 2.31 ) , anticoagulants vs low doses of ASA alone ( OR , 1.93 ; 95 % CI , 1.42 - 2.61 ) , or in studies that included patients with a history of GI bleeding or of longer duration .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clopidogrel","aspirin","ASA"],"drug_indices_start":[24,46,74],"drug_indices_end":[27,57,81]}
{"index":713,"text":"Raloxifene , an anti-osteoporotic drug , is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole , another anticancer drug .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Raloxifene","letrozole"],"drug_indices_start":[0,190],"drug_indices_end":[10,199]}
{"index":714,"text":"In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["flutamide","leuprolide acetate","leuprolide acetate"],"drug_indices_start":[60,73,276],"drug_indices_end":[69,91,294]}
{"index":715,"text":"Contraceptives containing desogestrel or levonorgestrel have different effects on serum lipoproteins and post-heparin plasma lipase activities .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["desogestrel","levonorgestrel"],"drug_indices_start":[26,41],"drug_indices_end":[37,55]}
{"index":716,"text":"Gastric mucosa biopsy samples obtained from children who had undergone upper gastrointestinal endoscopy were cultured for H. pylori , and susceptibility to six antibiotics ( clarithromycin , amoxicillin , gentamicin , furazolidone , metronidazole , and levofloxacin ) was tested from 2012 - 2014 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clarithromycin","amoxicillin","gentamicin","furazolidone","metronidazole","levofloxacin"],"drug_indices_start":[174,191,205,218,233,253],"drug_indices_end":[188,202,215,230,246,265]}
{"index":717,"text":"Concentrations of guaifenesin , diphenhydramine , and chlorpheniramine detected in the heart blood were 27.4 , 8.8 , and 0.2 mg\/L , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["guaifenesin","diphenhydramine","chlorpheniramine"],"drug_indices_start":[18,32,54],"drug_indices_end":[29,47,70]}
{"index":718,"text":"The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","actinomycin D","cyclophosphamide","doxorubicin","vincristine","doxorubicin","cyclophosphamide","ifosfamide","etoposide"],"drug_indices_start":[59,73,89,110,144,158,172,191,206],"drug_indices_end":[70,86,105,121,155,169,188,201,215]}
{"index":719,"text":"Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ceftriaxone","gentamicin","ceftriaxone"],"drug_indices_start":[0,17,31],"drug_indices_end":[11,27,42]}
{"index":720,"text":"Combined therapy : what does acamprosate and naltrexone combination tell us ?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["acamprosate","naltrexone"],"drug_indices_start":[29,45],"drug_indices_end":[40,55]}
{"index":721,"text":"Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atovaquone","pyrimethamine"],"drug_indices_start":[83,98],"drug_indices_end":[93,111]}
{"index":722,"text":"TVR can be used in combination with tenofovir , emtricitabine and raltegravir for patients with hemophilia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tenofovir","emtricitabine","raltegravir","TVR"],"drug_indices_start":[0,36,48,66],"drug_indices_end":[3,45,61,77]}
{"index":723,"text":"Almost all the isolates were resistant to Ampicillin and Tobramycin ( 99.3 % each ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ampicillin","Tobramycin"],"drug_indices_start":[42,57],"drug_indices_end":[52,67]}
{"index":724,"text":"Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms and restored the lipid properties of the meibomian gland secretion toward normal .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","doxycycline"],"drug_indices_start":[21,56],"drug_indices_end":[33,67]}
{"index":725,"text":"Pharmacy costs of cefazolin used as prophylaxis were more than twice the cost for cephapirin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefazolin","cephapirin"],"drug_indices_start":[18,82],"drug_indices_end":[27,92]}
{"index":726,"text":"PP-6 isolated from Tibetan Plateau could ferment raffinose , lactose , sorbitol , melibiose and sucrose , and LS-5 could ferment cottonseed sugar , laetrile , rhamnose , lactose , sorbitol , xylose , arabinose , melibiose and sucrose , but the same species of commercial strains could not use these sugars .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lactose","lactose","xylose"],"drug_indices_start":[61,170,191],"drug_indices_end":[68,177,197]}
{"index":727,"text":"Drug combinations , especially rapamycin + doxycycline may have promising anti-tumour effect in gliomas .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rapamycin","doxycycline"],"drug_indices_start":[31,43],"drug_indices_end":[40,54]}
{"index":728,"text":"Treatment with PUVA ( psoralen-ultraviolet-A ) combined with 40 - -80 mg prednisolone and then with chemotherapy [ COPP regimen ( cyclophosphamide , vincristine , procarbacine , prednisone ) , high-dosage methotrexate followed by citrovorum factor rescue ] was not successful .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisolone","cyclophosphamide","vincristine","prednisone","methotrexate","psoralen-ultraviolet-A","procarbacine","citrovorum"],"drug_indices_start":[22,73,130,149,163,178,205,230],"drug_indices_end":[44,85,146,160,175,188,217,240]}
{"index":729,"text":"This population-based nonconcurrent cohort study of statewide California Cancer Registry data included all patients aged 40 to 85 years diagnosed with mCRC and treated with SC only or SC plus bevacizumab or cetuximab from January 1 , 2004 , through December 31 , 2014 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","cetuximab"],"drug_indices_start":[192,207],"drug_indices_end":[203,216]}
{"index":730,"text":"We evaluated a sequential treatment with Vinorelbine followed by Gemcitabine to determine its effect on survival and the toxicity in this patient population .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vinorelbine","Gemcitabine"],"drug_indices_start":[41,65],"drug_indices_end":[52,76]}
{"index":731,"text":"Apoptosis in Hep2 cells treated with etoposide and colchicine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","colchicine"],"drug_indices_start":[37,51],"drug_indices_end":[46,61]}
{"index":732,"text":"The objective of this phase II study was to evaluate the efficacy and toxicity of carboplatin and weekly paclitaxel combination chemotherapy in previously untreated , advanced non-small cell lung cancer ( NSCLC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel"],"drug_indices_start":[82,105],"drug_indices_end":[93,115]}
{"index":733,"text":"Therapy consisted of seven cycles of VCAP ( vincristine , cyclophosphamide , doxorubicin and prednisone ) , AMP ( doxorubicin , ranimustine and prednisone ) and VECP ( vindesine , etoposide , carboplatin and prednisone ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","cyclophosphamide","doxorubicin","prednisone","doxorubicin","ranimustine","prednisone","etoposide","carboplatin","prednisone","vindesine"],"drug_indices_start":[44,58,77,93,114,128,144,168,180,192,208],"drug_indices_end":[55,74,88,103,125,139,154,177,189,203,218]}
{"index":734,"text":"Indomethacin , naproxen and dexamethasone had no effect .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["naproxen","dexamethasone"],"drug_indices_start":[15,28],"drug_indices_end":[23,41]}
{"index":735,"text":"In HER2-amplified cells , the combination of trastuzumab and lapatinib was evaluated using the median effects principal .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","lapatinib"],"drug_indices_start":[45,61],"drug_indices_end":[56,70]}
{"index":736,"text":"To assess the effects of photosensitizing drugs voriconazole and hydrochlorothiazide ( HCTZ ) on the enhancement of UV-induced inflammatory responses and UV-induced tumorigenesis , we utilized Xpa-knockout mice , which is DNA repair-deficient and more susceptible to UV-induced inflammation and tumor development than wild-type mice .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["voriconazole","hydrochlorothiazide"],"drug_indices_start":[48,65],"drug_indices_end":[60,84]}
{"index":737,"text":"Sorafenib monotherapy and combinations with taxanes , bevacizumab and ixabepilone showed inadequate efficacy , while efficacy results from combinations with gemcitabine and\/or capecitabine and possibly tamoxifen were more promising .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sorafenib","bevacizumab","ixabepilone","gemcitabine","capecitabine","tamoxifen"],"drug_indices_start":[0,54,70,157,176,202],"drug_indices_end":[9,65,81,168,188,211]}
{"index":738,"text":"This article reviews the pertinent studies regarding paclitaxel combined with cisplatin or carboplatin , discusses the remaining controversies surrounding how best to combine these agents , and provides opinions regarding the discordant outcomes noted in studies of the paclitaxel-platinum doublet .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","cisplatin","carboplatin"],"drug_indices_start":[53,78,91],"drug_indices_end":[63,87,102]}
{"index":739,"text":"The results indicate that neomycin only inhibits the growth of susceptible bacteria ( E. coli , Staph . aureus ) which , conversely , are poor lactitol fermenters .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["neomycin","lactitol"],"drug_indices_start":[26,143],"drug_indices_end":[34,151]}
{"index":740,"text":"Hyperthermia could increase the sensitivity of SKOV3 to cis-platinum , carboplatin and oxaliplatin ( P < 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cis-platinum","carboplatin","oxaliplatin","Hyperthermia"],"drug_indices_start":[0,56,71,87],"drug_indices_end":[12,68,82,98]}
{"index":741,"text":"A prospective phase 2 trial of short-course ( SC ) radiation therapy ( RT ) with 25 Gy over 5 fractions , followed by 4 cycles of 5-fluorouracil , oxaliplatin , and leucovorin ( mFOLFOX6 ) before surgery was recently completed at our institution .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil","oxaliplatin","leucovorin"],"drug_indices_start":[130,147,165],"drug_indices_end":[144,158,175]}
{"index":742,"text":"[ A case of advanced gastric cancer successfully treated with trastuzumab , capecitabine , and Cisplatin therapy followed by curative resection ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","capecitabine","Cisplatin"],"drug_indices_start":[62,76,95],"drug_indices_end":[73,88,104]}
{"index":743,"text":"Sulpiride plus hydroxyzine decrease tinnitus perception .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sulpiride","hydroxyzine"],"drug_indices_start":[0,15],"drug_indices_end":[9,26]}
{"index":744,"text":"' Arimidex ' ( anastrozole ) versus tamoxifen as adjuvant therapy in postmenopausal women with early breast cancer -- efficacy overview .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","tamoxifen"],"drug_indices_start":[15,36],"drug_indices_end":[26,45]}
{"index":745,"text":"We gave 2 , 3 , 5 and 5 mg\/day\/body of recombinant tissue plasminogen activator ( tPA ) followed by heparin and prostaglandin E1 ( PGE1 ) effectively and without significant side effect on days 9 , 10 , 13 and 14 , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tissue plasminogen activator","heparin","prostaglandin E1"],"drug_indices_start":[51,100,112],"drug_indices_end":[79,107,128]}
{"index":746,"text":"Roxithromycin and clarithromycin , 14-membered ring macrolides , potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Roxithromycin","clarithromycin"],"drug_indices_start":[0,18],"drug_indices_end":[13,32]}
{"index":747,"text":"The EVA regimen ( etoposide , vinblastine , doxorubicin ) is an attempt to substitute a known active agent , etoposide , for bleomycin and dacarbazine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","vinblastine","doxorubicin","etoposide","bleomycin","dacarbazine"],"drug_indices_start":[18,30,44,109,125,139],"drug_indices_end":[27,41,55,118,134,150]}
{"index":748,"text":"The treatment of advanced non-small-cell lung cancer ( NSCLC is based on the combination of platin and one of the following agents : taxanes , gemcitabine , vinorelbine or irinotecan .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","vinorelbine","irinotecan"],"drug_indices_start":[143,157,172],"drug_indices_end":[154,168,182]}
{"index":749,"text":"Carvedilol and imatinib mesylate alone reduced cell number , BrDU-LI , cAMP levels and spheroid volume .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Carvedilol","imatinib"],"drug_indices_start":[0,15],"drug_indices_end":[10,23]}
{"index":750,"text":"The recommended phase II dose ( RP2D ) was cytarabine 10 mg bid days 1 - 10 and sorafenib 600 mg\/day days 2 - 28 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cytarabine","sorafenib"],"drug_indices_start":[43,80],"drug_indices_end":[53,89]}
{"index":751,"text":"We performed a single-arm phase II trial of panitumumab in patients with KRAS wild-type metastatic colorectal cancer that had progressed on prior cetuximab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["panitumumab","cetuximab"],"drug_indices_start":[44,146],"drug_indices_end":[55,155]}
{"index":752,"text":"Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ABT-450","ritonavir","ombitasvir","dasabuvir","cyclosporine","tacrolimus"],"drug_indices_start":[40,77,109,147,252,278],"drug_indices_end":[47,86,119,156,264,288]}
{"index":753,"text":"In this study a new GC-MS method has been developed for direct analysis of five major steroid estrogens ( estrone , 17beta-estradiol , 17alpha-ethinylestradiol , dienestrol , and diethylstilbestrol ) in river sediments .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["estrone","diethylstilbestrol"],"drug_indices_start":[106,179],"drug_indices_end":[113,197]}
{"index":754,"text":"A series of derivatives , like dihydroartemisinin , artesunate , artemether , artether , had the same core chemical structure , and sesquiterpene lactone containing peroxide bridge constitute the basic chemical structure .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dihydroartemisinin","artesunate","artemether"],"drug_indices_start":[31,52,65],"drug_indices_end":[49,62,75]}
{"index":755,"text":"Antiplatelet therapy with dipyridamole , 100 mg q.i.d . , starting 2 days before surgery , followed by aspirin , 325 mg t.i.d . plus dipyridamole , 75 mg t.i.d . , 7 hours after surgery was assessed in the prevention of saphenous vein bypass graft occlusion .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dipyridamole","aspirin","dipyridamole"],"drug_indices_start":[26,103,133],"drug_indices_end":[38,110,145]}
{"index":756,"text":"Toxicity patterns following stepwise combinations of cyclophosphamide , methotrexate and fluorouracil .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","methotrexate","fluorouracil"],"drug_indices_start":[53,72,89],"drug_indices_end":[69,84,101]}
{"index":757,"text":"All patients were treated with the combination of lapatinib ( 1250 mg\/day , continuously ) and capecitabine ( 2000 mg\/m(2 ) on days 1 through 14 of a 21-day cycle ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","capecitabine"],"drug_indices_start":[50,95],"drug_indices_end":[59,107]}
{"index":759,"text":"Effect of curcumin , a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","doxorubicin"],"drug_indices_start":[10,58],"drug_indices_end":[18,69]}
{"index":760,"text":"It is well established that several of the older AEDs ( carbamazepine , phenytoin and phenobarbital ) , are strong inducers of the hepatic cytochrome P450 ( CYP ) 3A4 enzyme system , and are associated with increased the risk of contraceptive failure .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbamazepine","phenytoin"],"drug_indices_start":[56,72],"drug_indices_end":[69,81]}
{"index":761,"text":"Our goals were to : establish the maximum-tolerated dose of olaparib tablets combined with metronomic carboplatin and paclitaxel in patients with relapsed high-grade serous ovarian cancer ; evaluate dose-limiting toxicities ; and evaluate efficacy at the maximum tolerated dose .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olaparib","carboplatin","paclitaxel"],"drug_indices_start":[60,102,118],"drug_indices_end":[68,113,128]}
{"index":762,"text":"Abiraterone acetate ( CB7630 ) , a pregnenolone analog , is an orally administered small molecule that irreversibly inhibits a rate-limiting enzyme in androgen biosynthesis , CYP17 , and blocks the synthesis of androgens in the testes , adrenal glands and prostate without causing adrenal insufficiency .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Abiraterone","pregnenolone"],"drug_indices_start":[0,35],"drug_indices_end":[11,47]}
{"index":763,"text":"There was no significant correlation between the response to ferrochloroquine and those to mefloquine , halofantrine , primaquine , atovaquone or artesunate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","halofantrine","primaquine","atovaquone","artesunate"],"drug_indices_start":[91,104,119,132,146],"drug_indices_end":[101,116,129,142,156]}
{"index":764,"text":"All patients in this study were treated with decitabine of 15 mg\/m2 for 5 days and G-CSF for priming , in combination with cytarabine of 10-mg\/m2 q12h for 7 days and aclarubicin of 10 mg\/day for 4 days ( D-CAG ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["decitabine","cytarabine","aclarubicin"],"drug_indices_start":[45,123,166],"drug_indices_end":[55,133,177]}
{"index":765,"text":"In chronic musculoskeletal conditions with assessments over 6 to 12 weeks , topical diclofenac and ketoprofen had limited efficacy in hand and knee osteoarthritis , as did topical high-concentration capsaicin in postherpetic neuralgia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["diclofenac","ketoprofen"],"drug_indices_start":[84,99],"drug_indices_end":[94,109]}
{"index":766,"text":"Pertuzumab is the most recent agent approved by the US Food and Drug Administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2(+ ) metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Pertuzumab","trastuzumab","docetaxel"],"drug_indices_start":[0,104,120],"drug_indices_end":[10,115,129]}
{"index":767,"text":"Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","regorafenib","lenvatinib"],"drug_indices_start":[23,45,60],"drug_indices_end":[32,56,70]}
{"index":768,"text":"The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response ( SVR ) in phase III trials .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["boceprevir","telaprevir","peginterferon-alfa","ribavirin"],"drug_indices_start":[19,33,49,72],"drug_indices_end":[29,43,67,81]}
{"index":769,"text":"In contrast , the combination of plumbagin with AR antagonists , such as bicalutamide and enzalutamide , showed no improvement over AR antagonists alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bicalutamide","enzalutamide","plumbagin"],"drug_indices_start":[33,73,90],"drug_indices_end":[42,85,102]}
{"index":770,"text":"The B-cell lymphoma 2 ( BCL-2 ) inhibitor venetoclax has an emerging role in acute myeloid leukemia ( AML ) , with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["venetoclax","cytarabine"],"drug_indices_start":[42,195],"drug_indices_end":[52,205]}
{"index":771,"text":"Combination chemotherapy with vincristine , bleomycin , and methotrexate for advanced head and neck cancers .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","bleomycin","methotrexate"],"drug_indices_start":[30,44,60],"drug_indices_end":[41,53,72]}
{"index":772,"text":"Combination therapy with labetalol ( 400 mg\/day ) and prazosin ( 6 mg\/day ) was unsatisfactory , and the addition of long-acting nifedipine ( 40 mg\/day ) produced a marked decrease in blood pressure .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["labetalol","prazosin","nifedipine"],"drug_indices_start":[25,54,129],"drug_indices_end":[34,62,139]}
{"index":773,"text":"The monoclonal antibodies Ipilimumab , Pembrolizumab and Nivolumab , designed to interfere with T-cell inhibitory signals to activate immune responses against tumours , were originally approved as monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ipilimumab","Pembrolizumab","Nivolumab"],"drug_indices_start":[26,39,57],"drug_indices_end":[36,52,66]}
{"index":774,"text":"Recent studies have reported that the AI anastrozole has lower effectiveness than tamoxifen in women with high BMI .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","tamoxifen"],"drug_indices_start":[41,82],"drug_indices_end":[52,91]}
{"index":776,"text":"Conclusions Everolimus plus mFOLFOX-6 + bevacizumab is tolerable and demonstrated preliminary efficacy for first-line mCRC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Everolimus","bevacizumab","mFOLFOX-6"],"drug_indices_start":[12,28,40],"drug_indices_end":[22,37,51]}
{"index":777,"text":"Physician Utilization Patterns for VEGF-Inhibitor Drugs in the 2012 United States Medicare Population : Bevacizumab , Ranibizumab , and Aflibercept .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","Ranibizumab","Aflibercept"],"drug_indices_start":[104,118,136],"drug_indices_end":[115,129,147]}
{"index":778,"text":"Antimicrobials that can be used with confidence to treat NG infection currently in China include ceftriaxone and spectinomycin , but not penicillin , tetracycline , ciprofloxacin , and cefixime .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ceftriaxone","spectinomycin","penicillin","tetracycline","ciprofloxacin","cefixime"],"drug_indices_start":[97,113,137,150,165,185],"drug_indices_end":[108,126,147,162,178,193]}
{"index":779,"text":"A number of biologically targeted agents targeting the VEGF and mTOR signaling pathways have recently shown promise , with recent trials showing treatment with the VEGFR tyrosine kinase inhibitor sunitinib or the mTOR inhibitor everolimus improves progression-free survival in patients with advanced NET .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","everolimus"],"drug_indices_start":[196,228],"drug_indices_end":[205,238]}
{"index":780,"text":"We conducted a prospective phase II study to determine the response rate , toxicity , and survival rate of concurrent weekly paclitaxel , carboplatin , and hyperfractionated radiation therapy ( paclitaxel\/carboplatin\/HFX RT ) followed by 2 cycles of paclitaxel and carboplatin for locally advanced unresectable non-small cell lung cancer ( NSCLC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","paclitaxel","carboplatin"],"drug_indices_start":[125,138,250,265],"drug_indices_end":[135,149,260,276]}
{"index":781,"text":"A phase Ib study of pertuzumab , a recombinant humanised antibody to HER2 , and docetaxel in patients with advanced solid tumours .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertuzumab","docetaxel"],"drug_indices_start":[20,80],"drug_indices_end":[30,89]}
{"index":782,"text":"These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and\/or tissue factor expression on vascular endothelial cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vorinostat","doxorubicin"],"drug_indices_start":[24,39],"drug_indices_end":[34,50]}
{"index":783,"text":"Based on encouraging results of previous combination regimens , we used a combination of VM26 , ifosfamide , methyl GAG , mitoxantrone ( or adriamycin ) , high-dose ( HD ) methotrexate and HD Ara C to treat 18 patients with relapsed or refractory NHL .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["VM26","ifosfamide","methyl GAG ,","mitoxantrone","adriamycin","methotrexate","Ara C"],"drug_indices_start":[89,96,109,122,140,172,192],"drug_indices_end":[93,106,121,134,150,184,197]}
{"index":784,"text":"We treated this patient with six cycles of CHOEP ( Cyclophosphamide , Doxorubicin , Vincristine , Etoposide , and Prednisone ) chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cyclophosphamide","Doxorubicin","Vincristine","Etoposide","Prednisone"],"drug_indices_start":[51,70,84,98,114],"drug_indices_end":[67,81,95,107,124]}
{"index":785,"text":"One study evaluated gemcitabine with gemcitabine and pertuzumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","gemcitabine","pertuzumab"],"drug_indices_start":[20,37,53],"drug_indices_end":[31,48,63]}
{"index":786,"text":"Resistance could be abolished by structurally different chemosensitizers of P-glycoprotein function like verapamil and reserpine but not by the leukotriene receptor antagonist MK571 which is a modulator of the multidrug resistance-associated protein ( MRP ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","reserpine"],"drug_indices_start":[105,119],"drug_indices_end":[114,128]}
{"index":787,"text":"We conclude that the combination of thiotepa , 5FU , and leucovorin had significant myelotoxicity and do not recommend its routine use in the treatment of metastatic breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["thiotepa","5FU","leucovorin"],"drug_indices_start":[36,47,57],"drug_indices_end":[44,50,67]}
{"index":789,"text":"The saliva is shown to inhibit human platelet aggregation induced by thrombin , collagen , adenosine diphosphate ( ADP ) , epinephrine , platelet activating factor ( 1-O-alkyl-2-acetyl-sn-3-glycerophophoryl choline [ PAF ] ) , and arachidonic acid .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epinephrine","platelet activating factor"],"drug_indices_start":[123,137],"drug_indices_end":[134,163]}
{"index":790,"text":"This clinical trial compared the efficacy of paclitaxel and vinorelbine in breast cancer neoadjuvant chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","vinorelbine"],"drug_indices_start":[45,60],"drug_indices_end":[55,71]}
{"index":791,"text":"Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight ?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["l-leucine","metformin","sildenafil"],"drug_indices_start":[22,46,60],"drug_indices_end":[31,55,70]}
{"index":792,"text":"Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["linezolid","levofloxacin"],"drug_indices_start":[24,38],"drug_indices_end":[33,50]}
{"index":793,"text":"Canadian clinical guidelines recommend the use of the combination of tamsulosin and dutasteride for men with moderate\/severe symptoms associated with BPH and enlarged prostate volume .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamsulosin","dutasteride"],"drug_indices_start":[69,84],"drug_indices_end":[79,95]}
{"index":794,"text":"The present study was designed to test the effects of chronic combined treatment with low doses of an angiotensin converting enzyme inhibitor ( perindopril ) and of the diuretic indapamide in spontaneously hypertensive rats ( SHR ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["perindopril","indapamide"],"drug_indices_start":[144,178],"drug_indices_end":[155,188]}
{"index":795,"text":"A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azacitidine","fludarabine","cytarabine"],"drug_indices_start":[19,55,71],"drug_indices_end":[30,66,81]}
{"index":796,"text":"Five other treatments closely followed ( dabrafenib [ HR PFS : 0.30 ] , nivolumab plus ipilimumab [ HR PFS : 0.34 ] , vemurafenib [ HR PFS : 0.38 ] , nivolumab [ HR PFS : 0.42 ] and pembrolizumab [ HR PFS : 0.46 ] ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dabrafenib","nivolumab","ipilimumab","vemurafenib","nivolumab","pembrolizumab"],"drug_indices_start":[41,72,87,118,150,182],"drug_indices_end":[51,81,97,129,159,195]}
{"index":797,"text":"IGROV-1\/APL resistant cell line shows the typical MDR phenotype : ( 1 ) increased expression of membrane-associated P-glycoprotein , ( 2 ) cross-resistance to drugs like etoposide , doxorubicin , vinblastine , vincristine , taxol , colchicin and the novel anticancer drug Yondelis ( ET-743 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin","vinblastine","vincristine"],"drug_indices_start":[170,182,196,210],"drug_indices_end":[179,193,207,221]}
{"index":799,"text":"Phase 1b trial of docetaxel , prednisone , and pazopanib in men with metastatic castration-resistant prostate cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","prednisone","pazopanib"],"drug_indices_start":[18,30,47],"drug_indices_end":[27,40,56]}
{"index":801,"text":"Management and outcome : The patient was initially treated with bortezomib and dexamethasone for the myeloma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","dexamethasone"],"drug_indices_start":[64,79],"drug_indices_end":[74,92]}
{"index":802,"text":"Majority of the interventions were to stop the antimicrobial therapy ( 30.3 % ) , and the most common audited antimicrobials was Piperacillin\/Tazobactam ( 25.5 % ) , followed by Meropenem ( 11.82 % ) , Amoxicillin\/Clavulanate and Vancomycin ( 8.18 % ) respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Meropenem","Vancomycin"],"drug_indices_start":[178,230],"drug_indices_end":[187,240]}
{"index":803,"text":"Clinical Development of the CDK4\/6 Inhibitors Ribociclib and Abemaciclib in Breast Cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ribociclib","Abemaciclib"],"drug_indices_start":[46,61],"drug_indices_end":[56,72]}
{"index":804,"text":"We retrospectively evaluated 52 metastatic renal cell carcinoma patients who were treated with nivolumab plus ipilimumab between August 2015 and January 2020 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nivolumab","ipilimumab"],"drug_indices_start":[95,110],"drug_indices_end":[104,120]}
{"index":805,"text":"Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporin","escitalopram","escitalopram","escitalopram"],"drug_indices_start":[99,151,188,257],"drug_indices_end":[110,163,200,269]}
{"index":806,"text":"The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mezlocillin","carbenicillin","aminoglycoside","aminoglycoside"],"drug_indices_start":[19,38,90,112],"drug_indices_end":[30,52,103,126]}
{"index":807,"text":"Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg\/m2 ) and cyclophosphamide ( 700 mg\/m2 ) with or without the addition of Lenograstim .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatinum","cyclophosphamide","Lenograstim"],"drug_indices_start":[105,134,197],"drug_indices_end":[116,150,208]}
{"index":808,"text":"In particular , caspofungin for invasive candidiasis and voriconazole for invasive aspergillosis seem at least equivalent to amphotericin B. A clear advantage is the advent of lipid formulations of amphotericin B.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["caspofungin","voriconazole","amphotericin","amphotericin"],"drug_indices_start":[16,57,125,198],"drug_indices_end":[27,69,137,210]}
{"index":809,"text":"Ifosfamide at 12 g\/m2 was administered by intravenous continuous infusion over 3 days , and doxorubicin 60 mg\/m2 was administered as an intravenous bolus injection on day 1 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ifosfamide","doxorubicin"],"drug_indices_start":[0,92],"drug_indices_end":[10,103]}
{"index":810,"text":"A Randomized , Double-blind , Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women : A Pilot Study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Celecoxib","Sertraline"],"drug_indices_start":[58,84],"drug_indices_end":[67,94]}
{"index":811,"text":"The aim of this retrospective study was to investigate susceptibility rates of Mycobacterium tuberculosis complex ( MTBC ) isolates against streptomycin , rifampicin , isoniazid , and ethambutol between January 1998 and December 2000 in the Turkish Army .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["streptomycin","isoniazid","ethambutol"],"drug_indices_start":[140,168,184],"drug_indices_end":[152,177,194]}
{"index":812,"text":"JAK2 ATP competitive inhibitors ( ruxolitinib , lestaurtinib , SAR302503 , SB1518 and CYT387 ) or drugs that indirectly inhibit the JAK-STAT pathway ( everolimus ) have documented major effects on splenomegaly and its constitutional symptoms .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ruxolitinib","lestaurtinib","everolimus"],"drug_indices_start":[34,48,151],"drug_indices_end":[45,60,161]}
{"index":813,"text":"We therefore tested second-generation inhibitors of the 20S proteasome ( delanzomib , carfilzomib and ixazomib ) with better pharmacologic profiles as well as compounds targeting regulators of ubiquitination ( b-AP15 , MLN4924 ) for their effectiveness and mechanism of action in GIST .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["delanzomib","carfilzomib","ixazomib"],"drug_indices_start":[73,86,102],"drug_indices_end":[83,97,110]}
{"index":814,"text":"In seven patients with type B insulin resistance , standardized treatment with rituximab , cyclophosphamide , and pulse steroids results in remission of the disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cyclophosphamide","steroids"],"drug_indices_start":[79,91,120],"drug_indices_end":[88,107,128]}
{"index":816,"text":"The positive inotropism of DPDPE was abrogated in animals pretreated with propranolol , CGRP(8 - 37 ) , or combined propranolol+CGRP(8 - 37 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["DPDPE","propranolol","CGRP(8"],"drug_indices_start":[27,74,88],"drug_indices_end":[32,85,94]}
{"index":817,"text":"A case of Scedosporium apiospermum infection after BMT , treated initially with amphotericin B ( total dose of 2.5 g ) and then with itraconazole ( for 25 days ) , is reported here .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphotericin","itraconazole"],"drug_indices_start":[80,133],"drug_indices_end":[92,145]}
{"index":818,"text":"Thymidine Phosphorylase\/\u03b2-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","paclitaxel"],"drug_indices_start":[136,154],"drug_indices_end":[148,164]}
{"index":819,"text":"An equihypotensive dose of the calcium antagonist nifedipine had no significant effect ; however , EMD 52692 produced the same reduction in infarct size as had nicorandil .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nifedipine","nicorandil"],"drug_indices_start":[50,160],"drug_indices_end":[60,170]}
{"index":820,"text":"Intravesical epirubicin was generally tolerated as well as intravesical doxorubicin and was associated with a lower incidence of mild chemical cystitis in 1 clinical trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epirubicin","doxorubicin"],"drug_indices_start":[13,72],"drug_indices_end":[23,83]}
{"index":821,"text":"Modeling of the pharmacokinetic\/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irbesartan","hydrochlorothiazide"],"drug_indices_start":[68,83],"drug_indices_end":[78,102]}
{"index":822,"text":"We tested to what extent preincubation with the ribonucleotide reductase inhibitors fludarabine ( F-ara-A ) and hydroxyurea ( HU ) enhanced ara-CTP levels in two human myeloid ( HL-60 , CMK ) and two lymphoblastic leukemia cell lines ( MOLT-4 , BLIN-1 ) and also in blasts from 28 children with acute leukemia ( AML : 14 , ALL : 14 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","hydroxyurea"],"drug_indices_start":[84,112],"drug_indices_end":[95,123]}
{"index":823,"text":"In Group IV , the augmentation of Pdi by olprinone was abolished in the fatigued diaphragm with an infusion of nicardipine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olprinone","nicardipine"],"drug_indices_start":[41,111],"drug_indices_end":[50,122]}
{"index":824,"text":"Telmisartan inhibited TPA-induced cell proliferation stronger than candesartan .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Telmisartan","candesartan"],"drug_indices_start":[0,67],"drug_indices_end":[11,78]}
{"index":825,"text":"A single 1-g dose of oral azithromycin is as effective as a seven-day course of oral doxycycline , 100 mg twice a day , for the treatment of chlamydial infection .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","doxycycline"],"drug_indices_start":[26,85],"drug_indices_end":[38,96]}
{"index":826,"text":"The side-effects of halofantrine and mefloquine were comparable and transient .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["halofantrine","mefloquine"],"drug_indices_start":[20,37],"drug_indices_end":[32,47]}
{"index":827,"text":"Significantly , green tea polyphenols , as well as several flavonoids such as genistein , curcumin and resveratrol , have also been shown to have chemo-sensitizing properties in prostate , breast , hepatic , and lung tumors .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["genistein","curcumin","resveratrol"],"drug_indices_start":[78,90,103],"drug_indices_end":[87,98,114]}
{"index":828,"text":"In a 71 years-old patient , a severe therapy-resistant depressive episode without psychotic symptoms was successfully treated by a combination of paroxetine and risperidone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paroxetine","risperidone"],"drug_indices_start":[146,161],"drug_indices_end":[156,172]}
{"index":829,"text":"While there is no standard of care for PBL , current recommendations include dose-adjusted EPOCH ( etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) , with or without bortezomib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","vincristine","doxorubicin","cyclophosphamide","prednisone","bortezomib"],"drug_indices_start":[99,111,125,139,162,193],"drug_indices_end":[108,122,136,155,172,203]}
{"index":830,"text":"Our report of a patient with severe tardive dyskinesia ( TD ) who has been exposed to both typical antipsychotic and clozapine , olanzapine and quetiapine during a 124-week follow-up period supports the possible beneficial effect of atypical antipsychotics on pre-existing symptoms of TD .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clozapine","olanzapine","quetiapine"],"drug_indices_start":[117,129,144],"drug_indices_end":[126,139,154]}
{"index":831,"text":"Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer : a safety , feasibility , and efficacy study from the Hoosier Oncology Group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","bevacizumab"],"drug_indices_start":[0,16],"drug_indices_end":[10,27]}
{"index":832,"text":"On day ten of admission , HIT panel was positive , and Dabigatran was changed to Lepirudin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dabigatran","Lepirudin"],"drug_indices_start":[55,81],"drug_indices_end":[65,90]}
{"index":833,"text":"If in vivo testing confirms the in vitro effectiveness of azithromycin , it may prove to be the drug of choice for the treatment of scrub typhus in children and pregnant women , who should not take doxycycline , and in patients with refractory disease from locations where doxycycline-resistant strains of R. tsutsugamushi have been found .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","doxycycline"],"drug_indices_start":[58,198],"drug_indices_end":[70,209]}
{"index":834,"text":"Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1\/3 failed the cut-off criterion for either treatment alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["formoterol","budesonide"],"drug_indices_start":[40,55],"drug_indices_end":[50,65]}
{"index":836,"text":", olmesartan medoxomil + amlodipine + HCTZ was more effective in reducing BP and achieving BP goals than each of the dual therapies , irrespective of hypertension severity , age , sex , race or diabetes mellitus status .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["olmesartan medoxomil","amlodipine","HCTZ"],"drug_indices_start":[2,25,38],"drug_indices_end":[22,35,42]}
{"index":837,"text":"Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["telmisartan","hydrochlorothiazide"],"drug_indices_start":[34,53],"drug_indices_end":[45,72]}
{"index":838,"text":"The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rapamycin","temsirolimus","sorafenib"],"drug_indices_start":[91,111,127],"drug_indices_end":[100,123,136]}
{"index":839,"text":"The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma ( NB ) , who had been treated with 6 cycles of cyclophosphamide , doxorubicin , cisplatin , and etoposide for 12 months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","cisplatin","etoposide"],"drug_indices_start":[138,157,171,187],"drug_indices_end":[154,168,180,196]}
{"index":840,"text":"Days of utilization , adherence ( proportion of days covered \u22650.8 ) , and discontinuation ( non-use for \u226530 days immediately prior to BP measurement ) of three statins ( atorvastatin , pravastatin , and simvastatin ) over a period of up to 2 years was monitored retrospectively from electronic databases .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atorvastatin","pravastatin","simvastatin"],"drug_indices_start":[170,185,203],"drug_indices_end":[182,196,214]}
{"index":841,"text":"Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg\/m2 plus gemcitabine 700 mg\/m2 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trabectedin","gemcitabine"],"drug_indices_start":[169,196],"drug_indices_end":[180,207]}
{"index":842,"text":"Compared with alemtuzumab , bendamustine was considered to be a dominant treatment providing greater benefit ( 6.10 versus 5.37 life years and 4.02 versus 3.45 QALYs ) at lower cost ( $ 78,776 versus $ 121,441 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alemtuzumab","bendamustine"],"drug_indices_start":[14,28],"drug_indices_end":[25,40]}
{"index":843,"text":"He accepted surgical resection with followed multi-agent chemotherapy , containing vincristine , doxorubicin , ifosfamide and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","doxorubicin","ifosfamide","etoposide"],"drug_indices_start":[83,97,111,126],"drug_indices_end":[94,108,121,135]}
{"index":844,"text":"The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","mitoxantrone"],"drug_indices_start":[4,20],"drug_indices_end":[15,32]}
{"index":846,"text":"Neoadjuvant trastuzumab , pertuzumab , and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer ( KRISTINE ): a randomised , open-label , multicentre , phase 3 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","pertuzumab","trastuzumab emtansine","pertuzumab"],"drug_indices_start":[12,26,63,90],"drug_indices_end":[23,36,84,100]}
{"index":847,"text":"\u2265 3 adverse events ( AE ) than cetuximab and conatumumab , neutropenia than conatumumab , and fatigue than cetuximab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","conatumumab","conatumumab","cetuximab"],"drug_indices_start":[31,45,76,107],"drug_indices_end":[40,56,87,116]}
{"index":848,"text":"Ultimately , the patient was successfully treated with combination therapy of Liposomal amphotericin B and Miltefosine without any relapse .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphotericin","Miltefosine"],"drug_indices_start":[88,107],"drug_indices_end":[100,118]}
{"index":849,"text":"However , verapamil significantly increased the sensitivity to etoposide , doxorubicin and vincristine in cells highly expressing MRP gene .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","etoposide","doxorubicin","vincristine"],"drug_indices_start":[10,63,75,91],"drug_indices_end":[19,72,86,102]}
{"index":850,"text":"Based on available phase III randomized trials , anti-VEGF agents such as sunitinib , sorafenib , bevacizumab-based therapy , and mTOR-targeted agents such as temsirolimus and everolimus have been used in the treatment armamentarium for this disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","sorafenib","temsirolimus","everolimus"],"drug_indices_start":[74,86,159,176],"drug_indices_end":[83,95,171,186]}
{"index":851,"text":"Synergy was observed in vitro when HCT-116 cells were treated over a broad range of doses of trametinib and palbociclib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trametinib","palbociclib"],"drug_indices_start":[93,108],"drug_indices_end":[103,119]}
{"index":852,"text":"Simultaneous automated determination of free and total sulfisoxazole and sulfamethoxazole in plasma and urine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sulfisoxazole","sulfamethoxazole"],"drug_indices_start":[55,73],"drug_indices_end":[68,89]}
{"index":853,"text":"Background Epidemiological evidence is insufficient to draw conclusions on the impact of low-dose aspirin use on breast cancer risk , and the potential impact of other antiplatelet drugs such as clopidogrel needs to be explored .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","clopidogrel"],"drug_indices_start":[98,195],"drug_indices_end":[105,206]}
{"index":854,"text":"Using a FOLFOXIRI ( 5-fluorouracil [ 5-FU ] , irinotecan , and oxaliplatin ) combination regimen , patients with metastatic colorectal cancer now have the possibility of longer survival , but disappointingly , with increased toxicities .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["FOLFOXIRI","5-fluorouracil","5-FU","irinotecan","oxaliplatin"],"drug_indices_start":[8,20,37,46,63],"drug_indices_end":[17,34,41,56,74]}
{"index":855,"text":"Combinations of antibodies with targeted drugs like ibrutinib , idelalisib , or lenalidomide are expected to replace chemotherapy-based combinations for treating CLL in the near future .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["antibodies","ibrutinib","idelalisib","lenalidomide"],"drug_indices_start":[16,52,64,80],"drug_indices_end":[26,61,74,92]}
{"index":856,"text":"The responses to quinine and mefloquine or halofantrine showed no correlation with each other .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["quinine","mefloquine","halofantrine"],"drug_indices_start":[17,29,43],"drug_indices_end":[24,39,55]}
{"index":857,"text":"In a phase II study , we treated 26 consecutive patients with refractory advanced sarcoma with ifosfamide and etoposide combination chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","etoposide"],"drug_indices_start":[95,110],"drug_indices_end":[105,119]}
{"index":858,"text":"A case of delivery of healthy infant in breast cancer patient incidentally treated with goserelin acetate and tamoxifen during pregnancy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["goserelin acetate","tamoxifen"],"drug_indices_start":[88,110],"drug_indices_end":[105,119]}
{"index":860,"text":"A new method for the quantitative analysis by liquid chromatography-tandem mass spectrometry ( LC-MS\/MS ) of five tyrosine kinase inhibitors ( afatinib , crizotinib , osimertinib , erlotinib and nintedanib ) used in the treatment of non-small cell lung cancer ( NSCLC ) was developed and validated in human plasma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["afatinib","crizotinib","osimertinib","erlotinib","nintedanib"],"drug_indices_start":[143,154,167,181,195],"drug_indices_end":[151,164,178,190,205]}
{"index":861,"text":"The objective of this study was to compare the effect of sildenafil alone and sildenafil with bosentan on severity of tricuspid regurgitation and duration of hospitalization in new-borns with persistent pulmonary hypertension .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sildenafil","sildenafil","bosentan"],"drug_indices_start":[57,78,94],"drug_indices_end":[67,88,102]}
{"index":862,"text":"In Crohn 's disease in remission after 6 months of azathioprine in combination with infliximab , 63.8 % of practitioners discontinued azathioprine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azathioprine","infliximab","azathioprine"],"drug_indices_start":[51,84,134],"drug_indices_end":[63,94,146]}
{"index":863,"text":"Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 ( Enzalutamide ) or Casodex ( Bicalutamide ) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Enzalutamide","Casodex","Bicalutamide"],"drug_indices_start":[62,80,90],"drug_indices_end":[74,87,102]}
{"index":864,"text":"Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ketoconazole","hydrocortisone"],"drug_indices_start":[81,98],"drug_indices_end":[93,112]}
{"index":865,"text":"Randomized trial of betahistine mesilate tablets as augmentation for oxcarbazepine and carbamazepine in treating vestibular paroxysmia .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["betahistine","oxcarbazepine","carbamazepine"],"drug_indices_start":[20,69,87],"drug_indices_end":[31,82,100]}
{"index":866,"text":"Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer : a study of the Princess Margaret Hospital Phase II Consortium .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sorafenib","gemcitabine"],"drug_indices_start":[0,30],"drug_indices_end":[9,41]}
{"index":867,"text":"Pharmacological inhibition of p70S6 K using the PI3K\/mTOR inhibitor NVP-BEZ235 , the specific mTOR inhibitor Rapamycin and the specific p70S6 K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Rapamycin","Selumetinib","NVP-BEZ235","PF-4708671"],"drug_indices_start":[68,109,154,177],"drug_indices_end":[78,118,164,188]}
{"index":868,"text":"Vinorelbine , ifosfamide and cisplatin as first-line treatment in patients with inoperable non-small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vinorelbine","ifosfamide","cisplatin"],"drug_indices_start":[0,14,29],"drug_indices_end":[11,24,38]}
{"index":869,"text":"Two large Phase III trials conducted in the Americas and across Europe , Australia , and Asia showed lower cumulative pregnancy rates in the NOMAC\/E2 groups compared to the drospirenone ( DRSP ) 3 mg in combination with ethinyl estradiol ( EE ) 30 \u00b5g ( DRSP\/EE ) groups but this difference was not statistically significant .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["drospirenone","ethinyl estradiol"],"drug_indices_start":[173,220],"drug_indices_end":[185,237]}
{"index":871,"text":"The objective was to compare the pharmacodynamic ( PD ) and pharmacokinetic ( PK ) effects of ticagrelor with clopidogrel among subjects of Hispanic ethnicity , as the PD and PK effects of antiplatelet agents among Hispanics are not specifically known .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ticagrelor","clopidogrel"],"drug_indices_start":[94,110],"drug_indices_end":[104,121]}
{"index":872,"text":"For example , the renal excretion of methotrexate by glomerular filtration and tubular secretion is affected by a number of weak organic acids , such as probenecid , salicylates and penicillin , which compete for tubular secretion , resulting in delayed clearance of methotrexate .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","probenecid","salicylates","penicillin","methotrexate"],"drug_indices_start":[37,153,166,182,267],"drug_indices_end":[49,163,177,192,279]}
{"index":873,"text":"To investigate the cardiac safety of adjuvant Non-Pegylated Liposomal Doxorubicin ( NPL-DOX ) combined to Cyclophosphamide ( CTX ) and followed by weekly Paclitaxel , in older patients ( \u226565 years ) with diagnosis of high risk breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Doxorubicin","Cyclophosphamide","Paclitaxel"],"drug_indices_start":[70,106,154],"drug_indices_end":[81,122,164]}
{"index":874,"text":"The high incidence of imported malaria ( 0.70 % ) and the low costs of providing chemoprophylaxis resulted in a cost-benefit ratio of 0.19 for chloroquine and proguanil and 0.57 for a regimen containing mefloquine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","proguanil","mefloquine"],"drug_indices_start":[143,159,203],"drug_indices_end":[154,168,213]}
{"index":875,"text":"Clinical trials suggest reduced benefit from the combination of cetuximab with oxaliplatin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","oxaliplatin"],"drug_indices_start":[64,79],"drug_indices_end":[73,90]}
{"index":876,"text":"L-carnitine was administered 1 h before doxorubicin injection and daily thereafter for 15 days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["L-carnitine","doxorubicin"],"drug_indices_start":[0,40],"drug_indices_end":[11,51]}
{"index":877,"text":"New chemotherapeutic agents such as gemcitabine appear to have the potential to produce better results than those achieved over the last 35 years with fluorouracil .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","fluorouracil"],"drug_indices_start":[36,151],"drug_indices_end":[47,163]}
{"index":878,"text":"Comparative effectiveness of rituximab , abatacept , and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors : prospective cohort study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","abatacept","tocilizumab"],"drug_indices_start":[29,41,57],"drug_indices_end":[38,50,68]}
{"index":880,"text":"Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","methylprednisolone"],"drug_indices_start":[17,48],"drug_indices_end":[33,66]}
{"index":881,"text":"These adverse effects were all more frequent than with docetaxel or pemetrexed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","pemetrexed"],"drug_indices_start":[55,68],"drug_indices_end":[64,78]}
{"index":882,"text":"Hyper-CVAD , given in odd-number courses ( Courses 1 , 3 , 5 , and 7 ) , was alternated with methotrexate and cytarabine ( MTX\/Ara-C ) , given in even-number courses ( Courses 2 , 4 , 6 , and 8) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","cytarabine"],"drug_indices_start":[93,110],"drug_indices_end":[105,120]}
{"index":883,"text":"Despite systemic chemotherapy combining pemetrexed , bevacizumab and Cisplatinum , the disease relapsed eight months later with multiple metastatic lung nodules leading to a treatment shift .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pemetrexed","bevacizumab","Cisplatinum"],"drug_indices_start":[40,53,69],"drug_indices_end":[50,64,80]}
{"index":884,"text":"Trastuzumab , which is still the first-line therapy in breast cancer , increases the pCR rate more than lapatinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Trastuzumab","lapatinib"],"drug_indices_start":[0,104],"drug_indices_end":[11,113]}
{"index":885,"text":"Recently , several novel agents are under clinical development for advanced colorectal cancer , including irinotecan , oxaliplatin , oral fluoropyrimidines , raltitrexed , monoclonal antibody 17 - 1A and tumour vaccines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","oxaliplatin","raltitrexed"],"drug_indices_start":[106,119,158],"drug_indices_end":[116,130,169]}
{"index":886,"text":"Pretreatment with NaHCO3 , NH4Cl , SKF 525A , piperonyl butoxide , progesterone , cysteamine , phenobarbital or metyrapone prior to the administration of [methyl-14C]nicotine was studied .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["NaHCO3","NH4Cl","SKF 525A","piperonyl butoxide","progesterone","cysteamine","phenobarbital","metyrapone","[methyl-14C]nicotine"],"drug_indices_start":[18,27,35,46,67,82,95,112,154],"drug_indices_end":[24,32,43,64,79,92,108,122,174]}
{"index":887,"text":"Capecitabine is an oral pro-drug of fluorouracil .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Capecitabine","fluorouracil"],"drug_indices_start":[0,36],"drug_indices_end":[12,48]}
{"index":888,"text":"However , the current artemisinin FDC products , such as \u03b2-artemether and lumefantrine , are inherently unstable and require controlled distribution and storage conditions , which are not always available in resource-limited settings .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artemisinin","lumefantrine"],"drug_indices_start":[22,74],"drug_indices_end":[33,86]}
{"index":889,"text":"Because the mass invaded the pancreas and superior mesenteric vein as well as duodenum and the disease was disseminated to liver and peritoneum , she received palliative chemotherapy using vincristine , doxorubicin , cyclophosphamide , ifosfamide , and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","doxorubicin","cyclophosphamide","ifosfamide","etoposide"],"drug_indices_start":[189,203,217,236,253],"drug_indices_end":[200,214,233,246,262]}
{"index":890,"text":"In HCV genotype 1 infection and F3 or F4 liver fibrosis , treatment with boceprevir or telaprevir in addition to pegylated interferon and ribavirin is recommended .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["boceprevir","telaprevir","pegylated interferon","ribavirin"],"drug_indices_start":[73,87,113,138],"drug_indices_end":[83,97,133,147]}
{"index":891,"text":"Membrane-modifying agents such as reserpine , calcium antagonists ( nicardipine , verapamil ) and calmodulin inhibitor ( trifluoperazine ) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 ( C 6\/ACNU ) glioma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["reserpine","nicardipine","verapamil","trifluoperazine"],"drug_indices_start":[34,68,82,121],"drug_indices_end":[43,79,91,136]}
{"index":892,"text":"To investigate the efficacy of temozolomide in relation to response rate , toxicity , time to progression . and median survival time , a phase II study was conducted in patients with recurrent high-grade glioma following surgery plus radiotherapy and first-line chemotherapy based on nitrosourea , procarbazine and vincristine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["temozolomide","procarbazine","vincristine"],"drug_indices_start":[31,298,315],"drug_indices_end":[43,310,326]}
{"index":893,"text":"Ketoconazole inhibited the entire pathway , while exposure to genistein resulted in increased hormone levels upstream of 3-\u03b2-hydroxysteroid dehydrogenase ( 3\u03b2-HSD ) and decreases downstream .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ketoconazole","genistein"],"drug_indices_start":[0,62],"drug_indices_end":[12,71]}
{"index":894,"text":"Melphalan , cisplatin , carboplatin , doxorubicin , and etoposide cytotoxicities were determined by DIMSCAN assay .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Melphalan","cisplatin","carboplatin","doxorubicin","etoposide"],"drug_indices_start":[0,12,24,38,56],"drug_indices_end":[9,21,35,49,65]}
{"index":895,"text":"As a treatment at the time of progression after pemetrexed-based chemotherapy , erlotinib conferred a survival benefit when compared to docetaxel ( p=0.024 ; hazard ratio , 0.377 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","docetaxel"],"drug_indices_start":[80,136],"drug_indices_end":[89,145]}
{"index":896,"text":"The combination of ifosfamide with oral etoposide appears to have significant but manageable toxicity and encouraging efficacy in platinum resistant ovarian cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","etoposide"],"drug_indices_start":[19,40],"drug_indices_end":[29,49]}
{"index":897,"text":"After switching from ranibizumab treatment to aflibercept , ORTs remained present in 75 % of eyes , and significant reductions in CMT , PED , and SRF , and presence of intraretinal cysts were observed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ranibizumab","aflibercept"],"drug_indices_start":[21,46],"drug_indices_end":[32,57]}
{"index":898,"text":"Vinorelbine , gemcitabine , docetaxel , paclitaxel , and irinotecan are all new chemotherapeutic agents which have shown promising activity in this disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vinorelbine","gemcitabine","docetaxel","paclitaxel","irinotecan"],"drug_indices_start":[0,14,28,40,57],"drug_indices_end":[11,25,37,50,67]}
{"index":900,"text":"This document attempts to provide reasonable guidance for the use of antimicrobials which have uncertain benefit but may increase risk of QT interval prolongation and ventricular proarrhythmia , notably , chloroquine , hydroxychloroquine , azithromycin , and lopinavir\/ritonavir .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","hydroxychloroquine","azithromycin"],"drug_indices_start":[205,219,240],"drug_indices_end":[216,237,252]}
{"index":901,"text":"Phase II study of weekly paclitaxel and sorafenib as second\/third-line therapy in patients with adrenocortical carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","sorafenib"],"drug_indices_start":[25,40],"drug_indices_end":[35,49]}
{"index":902,"text":"This study indicates that cyclophosphamide , doxorubicin , and methotrexate are , at best , marginally active as single agents , and new drugs with more efficacy are needed before combination chemotherapy can be expected to result in any meaningful prolongation of survival in non-small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","methotrexate"],"drug_indices_start":[26,45,63],"drug_indices_end":[42,56,75]}
{"index":903,"text":"The combined treatment of curcumin and docetaxel inhibited the proliferation and induced apoptosis significantly higher than the curcumin and docetaxel-treated group alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","docetaxel","curcumin"],"drug_indices_start":[26,39,129],"drug_indices_end":[34,48,137]}
{"index":904,"text":"Previously , a study of ours showed that the combination of dabrafenib and trametinib improves progression-free survival compared with dabrafenib and placebo in patients with BRAF Val600Lys\/Glu mutation-positive metastatic melanoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dabrafenib","trametinib","dabrafenib"],"drug_indices_start":[60,75,135],"drug_indices_end":[70,85,145]}
{"index":905,"text":"compared to those for rats treated with trovafloxacin or clindamycin plus gentamicin","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clindamycin","gentamicin"],"drug_indices_start":[57,74],"drug_indices_end":[68,84]}
{"index":906,"text":"We suggest topoisomerase II inhibition by Aroclor 1254 , trovafloxacin , doxorubicin , and etoposide to be responsible for significant co-localization of regulated genes through the inability of the stabilized enzyme complexes to religate DNA .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trovafloxacin","doxorubicin","etoposide"],"drug_indices_start":[57,73,91],"drug_indices_end":[70,84,100]}
{"index":907,"text":"All but one received two induction courses of the 3 day-AVI ( doxorubicin 50 mg\/m(2 ) day 1 , etoposide 120 mg\/m(2 ) day 1 , 2 , 3 , ifosfamide 2000 mg\/m(2 ) day 1 , 2 ) regimen .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide","ifosfamide"],"drug_indices_start":[62,94,133],"drug_indices_end":[73,103,143]}
{"index":908,"text":"Although anti-HER2 ( trastuzumab ) and anti-VEGFR ( ramucirumab ) may yield survival benefit , anti-EGFR and anti-HGFR therapies have failed to improve outcomes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","ramucirumab"],"drug_indices_start":[21,52],"drug_indices_end":[32,63]}
{"index":909,"text":"In the phase I trial , 19 patients received bolus doxorubicin ( 50 mg\/m2 ) followed after a 16-hour interval by paclitaxel ( given at dose levels ranging from 130 to 250 mg\/m2 ) by 3-hour infusion every 3 weeks , for a maximum of eight cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","paclitaxel"],"drug_indices_start":[50,112],"drug_indices_end":[61,122]}
{"index":910,"text":"New monoclonal antibodies ( ofatumumab ) , second-generation proteasome inhibitors ( carfilzomib ) , mammalian target of rapamycin inhibitors , and Bruton 's tyrosine kinase inhibitors are promising and may expand future treatment options .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ofatumumab","carfilzomib","rapamycin"],"drug_indices_start":[28,85,121],"drug_indices_end":[38,96,130]}
{"index":911,"text":"Exposure of LLC-PK1 cells to hydrogen peroxide ( 2.5 mM ) resulted in a significant increase in the bleomycin-detectable iron ( iron capable of catalyzing free radical reactions ) content that was prevented by cimetidine , but not ranitidine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["hydrogen peroxide","cimetidine","ranitidine"],"drug_indices_start":[29,210,231],"drug_indices_end":[46,220,241]}
{"index":912,"text":"Patients who did or did not respond to previous DIMARD therapy either on i.m . gold , D-Penicillamine or Chloroquine , did usually well when treated with Auranofin , even if severe side effects leading to withdrawal had occurred on previous therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Chloroquine","Auranofin"],"drug_indices_start":[105,154],"drug_indices_end":[116,163]}
{"index":913,"text":"Patients were randomly assigned 1:1 centrally to either the docetaxel , prednisone , and custirsen combination or docetaxel and prednisone alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","prednisone","custirsen","docetaxel","prednisone"],"drug_indices_start":[60,72,89,114,128],"drug_indices_end":[69,82,98,123,138]}
{"index":914,"text":"[ Carboplatin and etoposide combination for the treatment of recurrent epithelial ovarian cancer ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Carboplatin","etoposide"],"drug_indices_start":[2,18],"drug_indices_end":[13,27]}
{"index":915,"text":"One-hour paclitaxel plus carboplatin in the treatment of advanced non-small cell lung cancer : results of a multicentre , phase II trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[9,25],"drug_indices_end":[19,36]}
{"index":916,"text":"Preliminary data combining trastuzumab with the antiangiogenic antibody bevacizumab is encouraging ; this combination will be tested in both early stage and late stage disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","bevacizumab"],"drug_indices_start":[27,72],"drug_indices_end":[38,83]}
{"index":918,"text":"A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and , especially , after combined treatment , which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["melatonin","cyclophosphamide"],"drug_indices_start":[102,116],"drug_indices_end":[111,132]}
{"index":919,"text":"The combination of rituximab , bendamustine , and cytarabine ( R-BAC ) was highly active in a pilot trial of mantle cell lymphoma , but its use was restricted by high haematological toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","bendamustine","cytarabine"],"drug_indices_start":[19,31,50],"drug_indices_end":[28,43,60]}
{"index":920,"text":"Despite treatment with PH specific therapy ( sildenafil , ambrisentan , and epoprostenol ) , her condition worsened rapidly with acute right heart failure ( RHF ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sildenafil","ambrisentan","epoprostenol"],"drug_indices_start":[45,58,76],"drug_indices_end":[55,69,88]}
{"index":921,"text":"Data from the present study show the feasibility and tolerability of combination ixabepilone plus carboplatin , with ixabepilone administered on day 1 or on days 1 and 8 on a 21-day cycle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ixabepilone","carboplatin","ixabepilone"],"drug_indices_start":[81,98,117],"drug_indices_end":[92,109,128]}
{"index":922,"text":"Compared to other glucose lowering agents except metformin , gliclazide was slightly more effective ( -0.13 % ( 95%CI : -0.25 , -0.02 , I(2 ) 55 % ) ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metformin","gliclazide"],"drug_indices_start":[49,61],"drug_indices_end":[58,71]}
{"index":923,"text":"Thirteen stage III B and 13 stage IV patients received intermediate doses of ifosfamide ( 1000 mg\/m2 ) , carboplatin ( 120 mg\/m2 ) and etoposide ( 120 mg\/m2 ) given intravenously on day 1 to 3 every 4 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","carboplatin","etoposide"],"drug_indices_start":[77,105,135],"drug_indices_end":[87,116,144]}
{"index":924,"text":"This study compared immediate ( overnight ) and progressive switching to oxcarbazepine monotherapy in patients with partial seizures unsatisfactorily treated with carbamazepine monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxcarbazepine","carbamazepine"],"drug_indices_start":[73,163],"drug_indices_end":[86,176]}
{"index":925,"text":"In conclusion , prasugrel can be used successfully in most patients with a history of clopidogrel hypersensitivity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prasugrel","clopidogrel"],"drug_indices_start":[16,86],"drug_indices_end":[25,97]}
{"index":926,"text":"Fresh , clinical P. falciparum isolates were also tested in the presence of several drugs , including chloroquine , mefloquine , quinine , halofantrine , atovaquone and qinghaosu derivatives .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","mefloquine","quinine","halofantrine","atovaquone"],"drug_indices_start":[102,116,129,139,154],"drug_indices_end":[113,126,136,151,164]}
{"index":927,"text":"The null hypothesis was there is no difference with respect to pain scores between ketorolac and iliac crest bupivacaine infusion as analgesic adjuncts to intravenous opioids .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ketorolac","bupivacaine"],"drug_indices_start":[83,109],"drug_indices_end":[92,120]}
{"index":928,"text":"Etoposide in combination with low-dose CAG ( cytarabine , aclarubicin , G-CSF ) for the treatment of relapsed or refractory acute myeloid leukemia : a multicenter , randomized control trial in southwest China .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Etoposide","cytarabine","aclarubicin","G-CSF"],"drug_indices_start":[0,45,58,72],"drug_indices_end":[9,55,69,77]}
{"index":929,"text":"were randomized in an open-label , crossover fashion to treatment A ( dolasetron 100 mg on day 1 ) and treatment B ( dolasetron 100 mg plus aprepitant 125 mg on day 1 , aprepitant 80 mg on days 2 - 3 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dolasetron","dolasetron","aprepitant","aprepitant"],"drug_indices_start":[70,117,140,169],"drug_indices_end":[80,127,150,179]}
{"index":930,"text":"The regimen of gemcitabine combined with ifosfamide and anthracycline is feasible , tolerable and effective in patients with recurrent platinum resistant\/refractory epithelial ovarian cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","ifosfamide","anthracycline"],"drug_indices_start":[15,41,56],"drug_indices_end":[26,51,69]}
{"index":931,"text":"Second-line treatments consisted of cetuximab plus irinotecan for arm A , and oxaliplatin plus either 5-fluorouracil ( FOLFOX ) or capecitabine ( CapeOX ) for the control arms .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","irinotecan","oxaliplatin","5-fluorouracil","capecitabine"],"drug_indices_start":[36,51,78,102,131],"drug_indices_end":[45,61,89,116,143]}
{"index":932,"text":"In the UT-EC-1 cell line the growth inhibition was 72 % with paclitaxel , 54 % with carboplatin and 73 % with the combination of these compounds .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[61,84],"drug_indices_end":[71,95]}
{"index":934,"text":"Measurement and simulation results obtained in the batch experiments , spiked with the diclofenac and carbamazepine content of preclarified municipal wastewater shows comparably high biotransformation rates in the presence of growth substrates .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["diclofenac","carbamazepine"],"drug_indices_start":[87,102],"drug_indices_end":[97,115]}
{"index":935,"text":"Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ursodeoxycholic acid","taurine"],"drug_indices_start":[0,40],"drug_indices_end":[20,47]}
{"index":936,"text":"This study assessed the efficacy and safety of telaprevir in combination with peginterferon-\u03b1-2b ( PEG IFN ) and ribavirin ( RBV ) , for Japanese difficult-to-treat patients with hepatitis C virus ( HCV ) genotype 2 who had not achieved sustained virological response ( SVR ) during prior treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["telaprevir","peginterferon-\u03b1-2b","ribavirin"],"drug_indices_start":[47,78,113],"drug_indices_end":[57,96,122]}
{"index":938,"text":"The MX2 cells are cross-resistant to etoposide , teniposide , bisantrene , dactinomycin , 4'-(9-acridinylamino)methanesulfon-m-anisidide , and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids melphalan and mitomycin C. In addition , the MX2 cells display slight collateral sensitivity to bleomycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","teniposide","daunorubicin","doxorubicin","melphalan","mitomycin","bleomycin"],"drug_indices_start":[37,49,162,179,237,251,333],"drug_indices_end":[46,59,174,190,246,260,342]}
{"index":939,"text":"Combination of a betalactam antibiotic ( ampicillin or azlocillin ) or polymyxin B with rifampicin were studied with their administration in succession at various intervals in an experimental model of plague infection of albino mice .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","azlocillin","polymyxin","rifampicin"],"drug_indices_start":[41,55,71,88],"drug_indices_end":[51,65,80,98]}
{"index":940,"text":"Between August 1993 and September 1994 , 6010 patients were randomized to receive either reteplase ( n = 3004 ) or streptokinase ( n = 3006 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["reteplase","streptokinase"],"drug_indices_start":[89,115],"drug_indices_end":[98,128]}
{"index":941,"text":"In patients coinfected and treated for both HIV-1 and hepatitis C virus ( HCV ) , administration of ribavirin ( RBV ) may result in altered intracellular drug levels of nucleoside reverse transcriptase inhibitors through inhibition of inosine 5'-monophosphate dehydrogenase .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ribavirin","inosine"],"drug_indices_start":[100,235],"drug_indices_end":[109,242]}
{"index":942,"text":"Previous treatments with rituximab and with rituximab plus high dose glucocorticoids , as well as with cyclophosphamide , azathioprine , plasma exchange , hyperbaric therapy , VAC therapy , prostacyclin , mycophenolate mofetil and surgery , had previously failed .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","rituximab","cyclophosphamide","azathioprine","mycophenolate","glucocorticoids"],"drug_indices_start":[25,44,69,103,122,205],"drug_indices_end":[34,53,84,119,134,218]}
{"index":943,"text":"The decision to test a triple combination has led to the development of Fansimef , a fixed combination with tablets containing 250 mg mefloquine , 500 mg sulfadoxine and 25 mg pyrimethamine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","sulfadoxine","pyrimethamine"],"drug_indices_start":[134,154,176],"drug_indices_end":[144,165,189]}
{"index":944,"text":"The aim of this study was to evaluate three active agents , bleomycin ( BLM ) , epirubicin and carboplatin in a new combination ( BECA ) in terms of feasibility , activity and toxicity in patients with recurrent and metastatic squamous cell carcinoma of the head and neck .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","epirubicin","carboplatin"],"drug_indices_start":[60,80,95],"drug_indices_end":[69,90,106]}
{"index":945,"text":"Survival Benefits of Second-line Axitinib Versus Everolimus After First Line Sunitinib Treatment in Metastatic Renal Cell Carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Axitinib","Everolimus","Sunitinib"],"drug_indices_start":[33,49,77],"drug_indices_end":[41,59,86]}
{"index":946,"text":"A phase II trial of cytarabine , cisplatin , and etoposide was conducted in 38 patients with refractory stage III and IV non-Hodgkin 's lymphoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cytarabine","cisplatin","etoposide"],"drug_indices_start":[20,33,49],"drug_indices_end":[30,42,58]}
{"index":947,"text":"The combination of camrelizumab plus gemcitabine and cisplatin has a manageable toxicity profile and promising preliminary antitumour activity for this disease in treatment-naive patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["camrelizumab","gemcitabine","cisplatin"],"drug_indices_start":[19,37,53],"drug_indices_end":[31,48,62]}
{"index":948,"text":"His infection failed to respond to combinations of surgery , fluconazole and itraconazole .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluconazole","itraconazole"],"drug_indices_start":[61,77],"drug_indices_end":[72,89]}
{"index":949,"text":"The protective effect of tianeptine against PTZ seizures was mitigated when tianeptine was administered with naloxone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tianeptine","tianeptine","naloxone"],"drug_indices_start":[25,76,109],"drug_indices_end":[35,86,117]}
{"index":950,"text":"Twenty-one trials involving 3646 patients were included : 11 trials using beta-blockers ( 6 drugs ; 866 patients ) , 6 clonidine or mivazerol ( 614 patients ) , 3 diltiazem or verapamil ( 121 patients ) , and 1 nitroglycerin ( 45 patients ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonidine","diltiazem","verapamil"],"drug_indices_start":[119,163,176],"drug_indices_end":[128,172,185]}
{"index":951,"text":"The sensitivity of human neuroblastoma-derived cell lines , cell line-derived , and patient-derived xenograft ( PDX ) models with varying ALK statuses to crizotinib combined with topotecan and cyclophosphamide ( topo\/cyclo ) was examined .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["crizotinib","topotecan","cyclophosphamide"],"drug_indices_start":[154,179,193],"drug_indices_end":[164,188,209]}
{"index":952,"text":"Patients were randomised to either receive additional tretinoin ( 45mg\/m(2)\/day ) for 12 weeks ( arm A ) , or peg-interferon and ribavirin alone ( arm B ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tretinoin","ribavirin","peg-interferon"],"drug_indices_start":[54,110,129],"drug_indices_end":[63,124,138]}
{"index":953,"text":"This study sought to determine the efficacy and toxicity of weekly paclitaxel and carboplatin in CUP .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[67,82],"drug_indices_end":[77,93]}
{"index":954,"text":"To investigate the presence of extended spectrum and metallo \u03b2-lactamases ( MBLs ) in Pseudomonas aeruginosa isolates which are resistant to imipenem and ceftazidime that were isolated in a hospital in Mexico .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["imipenem","ceftazidime"],"drug_indices_start":[141,154],"drug_indices_end":[149,165]}
{"index":955,"text":"The patient achieved complete remission after two cycles of chemotherapy of daunorubicin , cytarabine and etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["daunorubicin","cytarabine","etoposide"],"drug_indices_start":[76,91,106],"drug_indices_end":[88,101,115]}
{"index":957,"text":"Protection against CsA-induced PST cell death was afforded by reduction in extracellular calcium levels in the media or addition of the calcium entry antagonists : verapamil , nifedipine or diltiazem .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","nifedipine","diltiazem"],"drug_indices_start":[164,176,190],"drug_indices_end":[173,186,199]}
{"index":958,"text":"This synergy was abrogated through siRNA knockdown of IkB. The synergistic effect of combining selinexor and bortezomib in vitro provides rationale for further investigation of this combination treatment for patients with high-risk neuroblastoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["selinexor","bortezomib"],"drug_indices_start":[95,109],"drug_indices_end":[104,119]}
{"index":959,"text":"Therapy included 4 or 8 intensive therapy elements N1 ( Etoposide 125 mg\/m2 day 1 - 4 , Vindesine 3 mg\/m2 day 1 , Cisplatin 40 mg\/m2 day 1 - 4 ) and N2 ( Vincristine 1.5 mg\/m2 day 1 + 8 , Dacarbazine 200 mg\/m2 day 1 - 5 , Ifosfamide 1500 mg\/ m2 day 1 - 5 , Doxorubicin 30 mg\/m2 day 6 + 7 ) in alternating order .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Etoposide","Cisplatin","Vincristine","Dacarbazine","Ifosfamide","Doxorubicin","Vindesine"],"drug_indices_start":[56,88,114,154,188,222,257],"drug_indices_end":[65,97,123,165,199,232,268]}
{"index":960,"text":"Mycophenolate mofetil , the prodrug of mycophenolic acid , is widely used for maintenance immunosuppressive therapy in renal transplant recipients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mycophenolate","mycophenolic acid"],"drug_indices_start":[0,39],"drug_indices_end":[13,56]}
{"index":961,"text":"Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tacrolimus","prednisone"],"drug_indices_start":[23,47],"drug_indices_end":[33,57]}
{"index":962,"text":"Vandetanib inhibited hENT1 , hENT2 , hCNT1 , hCNT2 , and hCNT3 , whereas erlotinib inhibited hENT1 and hCNT3 and gefitinib inhibited hENT1 and hCNT1 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vandetanib","erlotinib","gefitinib"],"drug_indices_start":[0,73,113],"drug_indices_end":[10,82,122]}
{"index":963,"text":"Genistein reduced Bcl-2 phosphorylation triggered by paclitaxel and vincristine without changing Bax protein expression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Genistein","paclitaxel","vincristine"],"drug_indices_start":[0,53,68],"drug_indices_end":[9,63,79]}
{"index":964,"text":"Combinations of antibiotics with gentamicin or rifampin in vitro did not significantly alter the killing rate but prevented emergence of subpopulations resistant to the latter .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gentamicin","rifampin"],"drug_indices_start":[33,47],"drug_indices_end":[43,55]}
{"index":965,"text":"This Nordic multicenter phase II study evaluated the efficacy and safety of oxaliplatin combined with the Nordic bolus schedule of fluorouracil ( FU ) and folinic acid ( FA ) as first-line treatment in metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","fluorouracil","folinic acid"],"drug_indices_start":[76,131,155],"drug_indices_end":[87,143,167]}
{"index":966,"text":"In xenograft studies , the combination of trastuzumab plus letrozole is equally effective in inhibiting growth of MCF-7Ca tumors as letrozole alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","letrozole","letrozole"],"drug_indices_start":[42,59,132],"drug_indices_end":[53,68,141]}
{"index":967,"text":"Reduction of rpS6 expression in Jurkat and HeLa cells attenuated apoptosis induced by TRAIL , but not those by other cell death signals , including tumor necrosis factor-alpha and cycloheximide , etoposide , doxorubicin , tunicamycin and staurosporine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin"],"drug_indices_start":[196,208],"drug_indices_end":[205,219]}
{"index":968,"text":"The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin , amikacin , and cefoxitin for 6 months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clarithromycin","amikacin","cefoxitin"],"drug_indices_start":[115,132,147],"drug_indices_end":[129,140,156]}
{"index":969,"text":"The methods have been utilized to evaluate the pharmacokinetics and bioavailability of oral dosage forms containing levodopa and carbidopa .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levodopa","carbidopa"],"drug_indices_start":[116,129],"drug_indices_end":[124,138]}
{"index":970,"text":"Increasing the temperature from 60 \u00b0 C to 100 \u00b0 C decreased the half-life of amoxicillin ( 372 to 50 min ) , ampicillin ( 741 to 26 min ) , cloxacillin ( 367 to 46 min ) , and penicillin G ( 382 to 43 min ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amoxicillin","ampicillin","cloxacillin"],"drug_indices_start":[77,109,140],"drug_indices_end":[88,119,151]}
{"index":971,"text":"Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["moxifloxacin","levofloxacin","pyrazinamide"],"drug_indices_start":[16,32,101],"drug_indices_end":[28,44,113]}
{"index":972,"text":"High-level resistance to quinolones was frequently observed ( 21 % ) , but resistance to erythromycin ( 3 % ) and tetracycline ( 5 % ) was rare .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erythromycin","tetracycline"],"drug_indices_start":[89,114],"drug_indices_end":[101,126]}
{"index":973,"text":"The addition of tamoxifen did not worsen the known side effects of gefitinib , or induce additional side effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamoxifen","gefitinib"],"drug_indices_start":[16,67],"drug_indices_end":[25,76]}
{"index":974,"text":"A topical combination of 0.25 % finasteride and 3 % minoxidil may be a promising option in the treatment of FPHL with an additional benefit of increasing hair diameter .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["finasteride","minoxidil"],"drug_indices_start":[32,52],"drug_indices_end":[43,61]}
{"index":975,"text":"This report is the first about the long-term use of dasatinib in patients with Ph+ all and mrd elevation but hematologic remission during imatinib chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dasatinib","imatinib"],"drug_indices_start":[52,138],"drug_indices_end":[61,146]}
{"index":976,"text":"Acute verapamil toxicity in a patient with chronic toxicity : possible interaction with ceftriaxone and clindamycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","ceftriaxone","clindamycin"],"drug_indices_start":[6,88,104],"drug_indices_end":[15,99,115]}
{"index":977,"text":"Eighty-three patients were treated with rituximab , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-CHOP ) , 7 with rituximab , etoposide , cyclophosphamide , doxorubicin , vincristine , prednisone ( R-EPOCH ) , and 6 with R-CHOP with methotrexate , 3 g\/m(2 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cyclophosphamide","doxorubicin","vincristine","prednisone","R-CHOP","rituximab","etoposide","cyclophosphamide","doxorubicin","vincristine","prednisone","methotrexate","R-CHOP"],"drug_indices_start":[40,52,71,85,99,112,130,142,154,173,187,201,237,249],"drug_indices_end":[49,68,82,96,109,118,139,151,170,184,198,211,243,261]}
{"index":978,"text":"More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia ( CLL ) who are not eligible for chemoimmunotherapy with fludarabine , cyclophosphamide , and rituximab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","cyclophosphamide","rituximab"],"drug_indices_start":[153,167,190],"drug_indices_end":[164,183,199]}
{"index":979,"text":"Among them , 18 ( 85.7 % ) patients had disease control with gefitinib and 12 ( 57.1 % ) patients with salvage erlotinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","erlotinib"],"drug_indices_start":[61,111],"drug_indices_end":[70,120]}
{"index":980,"text":"In addition to its reproductive function , kisspeptin signalling is also involved in extra-hypothalamic-pituitary-gonadal ( HPG ) axis systems , including oxytocin and arginine vasopressin ( AVP ) secretion .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxytocin","vasopressin"],"drug_indices_start":[155,177],"drug_indices_end":[163,188]}
{"index":981,"text":"The combination of volasertib with pemetrexed did not improve efficacy compared with pemetrexed monotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["volasertib","pemetrexed","pemetrexed"],"drug_indices_start":[19,35,85],"drug_indices_end":[29,45,95]}
{"index":983,"text":"These results suggest that therapy with insulin plus dexamethasone but not therapy with leptin is beneficial for diabetics .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexamethasone","leptin","insulin"],"drug_indices_start":[40,53,88],"drug_indices_end":[47,66,94]}
{"index":984,"text":"After the first course of treatment , a statistically significant improvement ( p = 0.002 ) in the psychological subscale scores was observed after ondansetron compared with metoclopramide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ondansetron","metoclopramide"],"drug_indices_start":[148,174],"drug_indices_end":[159,188]}
{"index":985,"text":"The rate of grade 3 or 4 neutropenia was higher in the venetoclax-rituximab group than in the bendamustine-rituximab group , but the rates of grade 3 or 4 febrile neutropenia and infections or infestations were lower with venetoclax than with bendamustine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["venetoclax","bendamustine"],"drug_indices_start":[222,243],"drug_indices_end":[232,255]}
{"index":986,"text":"This study investigated the efficacy and toxicity associated with consolidation chemotherapy using paclitaxel and carboplatin after concurrent chemoradiation ( CCR ) in cervical cancer patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[99,114],"drug_indices_end":[109,125]}
{"index":987,"text":"These secondary leukemias associated with topoisomerase II inhibitors ( most commonly teniposide , etoposide , or doxorubicin ) have distinct clinical and biologic features which have led to the speculation that they are induced by treatment with topoisomerase II inhibitors .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["teniposide","etoposide","doxorubicin"],"drug_indices_start":[86,99,114],"drug_indices_end":[96,108,125]}
{"index":988,"text":"In the intention to treat analysis , 14 patients receiving praziquantel were cured compared with none with mefloquine , one with artesunate ( odds ratio 0\u00b703 , 95 % CI 0\u00b7004 - 0\u00b729 ) , one with mefloquine-artesunate ( 0\u00b703 , 0\u00b7004 - 0\u00b729 ) , and 19 with tribendimidine ( 1\u00b787 , 0\u00b760 - 5\u00b785 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["praziquantel","mefloquine","artesunate"],"drug_indices_start":[59,107,129],"drug_indices_end":[71,117,139]}
{"index":989,"text":"Cladribine with Granulocyte Colony-Stimulating Factor , Cytarabine , and Aclarubicin Regimen in Refractory\/Relapsed Acute Myeloid Leukemia : A Phase II Multicenter Study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cladribine","Granulocyte Colony-Stimulating Factor","Cytarabine","Aclarubicin"],"drug_indices_start":[0,16,56,73],"drug_indices_end":[10,53,66,84]}
{"index":990,"text":"In guinea pig trachea and human bronchial smooth muscle , SALM was more potent than isoprenaline ( ISO ) , salbutamol ( SALB ) , and clenbuterol ( CLEN ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["isoprenaline","salbutamol"],"drug_indices_start":[84,107],"drug_indices_end":[96,117]}
{"index":991,"text":"Combining erlotinib with doxorubicin or docetaxel or SN-38 resulted in additive or even synergistic antiproliferative effects .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","doxorubicin","docetaxel","SN-38"],"drug_indices_start":[10,25,40,53],"drug_indices_end":[19,36,49,58]}
{"index":992,"text":"Importantly , the risk of neutropenia 14 days after initiation of treatment with artesunate plus amodiaquine was higher among HIV-infected children than among HIV-uninfected children ( 45 % vs. 6 % ; p < .001 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artesunate","amodiaquine"],"drug_indices_start":[81,97],"drug_indices_end":[91,108]}
{"index":993,"text":"During this period , blood pressure ( BP ) was monitored weekly , and daily rhythms of melatonin , corticosterone , leptin and testosterone were evaluated at the end of the experiment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["melatonin","corticosterone","leptin","testosterone"],"drug_indices_start":[87,99,116,127],"drug_indices_end":[96,113,122,139]}
{"index":994,"text":"Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed : chloroquine , hydroxychloroquine , losartan , azithromycin , naproxen , dexamethasone and prednisone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","hydroxychloroquine","losartan","azithromycin","naproxen","dexamethasone","prednisone"],"drug_indices_start":[152,166,187,198,213,224,242],"drug_indices_end":[163,184,195,210,221,237,252]}
{"index":995,"text":"The present work is concerned with simultaneous determination of cefepime ( CEF ) and the co-administered drug , levofloxacin ( LEV ) , in spiked human plasma by applying a new approach , Savitzky-Golay differentiation filters , and combined trigonometric Fourier functions to their ratio spectra .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefepime","levofloxacin"],"drug_indices_start":[65,113],"drug_indices_end":[73,125]}
{"index":996,"text":"Forthcoming data from phase 3 placebo-controlled trials of everolimus , one focused on monotherapy for pancreatic NET and the other on combination use with octreotide LAR for patients with advanced NET and a history of carcinoid syndrome , will provide insight into its future place in NET therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["everolimus","octreotide"],"drug_indices_start":[59,156],"drug_indices_end":[69,166]}
{"index":997,"text":"The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisone","azathioprine"],"drug_indices_start":[15,30],"drug_indices_end":[25,42]}
{"index":998,"text":"The analytical range for dihydroartemisinin , dihydroartemisinin-glucuronide and artesunate was 10 - 1000 ng\/ml and for artemether 90 - 3000 ng\/ml with a lower limit of quantification of 10 and 90 ng\/ml , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dihydroartemisinin","dihydroartemisinin-glucuronide","artesunate","artemether"],"drug_indices_start":[25,46,81,120],"drug_indices_end":[43,76,91,130]}
{"index":999,"text":"Amphotericin B MICs were reduced upon combination with rifabutin from a mean of 0.65 microg\/ml to a mean of 0.16 microg\/ml against Aspergillus , and from a mean of 0.97 microg\/ml to a mean of 0.39 microLg\/ml against Fusarium ( P < 0.000001 for both ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Amphotericin","rifabutin"],"drug_indices_start":[0,55],"drug_indices_end":[12,64]}
{"index":1000,"text":"Neoadjuvant therapy with gemcitabine plus doxorubicin results in a high tumor response rate with moderate oral and hematologic toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","doxorubicin"],"drug_indices_start":[25,42],"drug_indices_end":[36,53]}
{"index":1002,"text":"At cross over the ORR was 0 % and 18 % on cross over to vinorelbine and docetaxel respectively with a median TTP of 17.3 weeks ( 95 % CI , 16.3 - 18.1 ) and 18.7 weeks ( 95 % CI , 13.9 - 23.4 ) for those receiving vinorebine and docetaxel at cross over respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinorelbine","docetaxel","docetaxel"],"drug_indices_start":[56,72,229],"drug_indices_end":[67,81,238]}
{"index":1003,"text":"The drugs approved in Europe for the systemic treatment of herpes zoster are aciclovir , valaciclovir , famciclovir and brivudine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aciclovir","valaciclovir","famciclovir","brivudine"],"drug_indices_start":[77,89,104,120],"drug_indices_end":[86,101,115,129]}
{"index":1004,"text":"In this parallel group , randomized , double-blind study , 301 PD patients , the majority with motor fluctuations , received entacapone ( 200 mg ) or placebo with each daily dose of standard or controlled-release ( CR ) levodopa .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["entacapone","levodopa"],"drug_indices_start":[125,220],"drug_indices_end":[135,228]}
{"index":1005,"text":"Importance of adding neomycin to metronidazole for bowel preparation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["neomycin","metronidazole"],"drug_indices_start":[21,33],"drug_indices_end":[29,46]}
{"index":1006,"text":"The effects of metformin ( MET ) and curcumin ( CUR ) single treatments have been tested against breast cancer ; however , their combination has not been explored .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metformin","curcumin"],"drug_indices_start":[15,37],"drug_indices_end":[24,45]}
{"index":1007,"text":"Warfarin was associated with a significantly higher risk of MB ( HR = 1.52 , 95 % CI = 1.14 - 2.04 ) , CRNM bleeding ( HR = 1.27 , 95 % CI = 1017.15 - 1.40 ) , and recurrent VTE ( HR = 1.50 , 95 % CI = 1.24 - 1.82 ) compared with apixaban .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Warfarin","apixaban"],"drug_indices_start":[0,230],"drug_indices_end":[8,238]}
{"index":1009,"text":"Co-injection of the lowest doses of levobupivacaine and lidocaine dramatically increased the paw withdrawal latency .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levobupivacaine","lidocaine"],"drug_indices_start":[36,56],"drug_indices_end":[51,65]}
{"index":1011,"text":"Carboplatin and paclitaxel versus cisplatin , paclitaxel and doxorubicin for first-line chemotherapy of advanced ovarian cancer : a Hellenic Cooperative Oncology Group ( HeCOG ) study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Carboplatin","paclitaxel","cisplatin","paclitaxel","doxorubicin"],"drug_indices_start":[0,16,34,46,61],"drug_indices_end":[11,26,43,56,72]}
{"index":1012,"text":"For susceptibility testing , DS-8587 exhibited more effective antibacterial activity when compared with ciprofloxacin and levofloxacin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ciprofloxacin","levofloxacin"],"drug_indices_start":[104,122],"drug_indices_end":[117,134]}
{"index":1013,"text":"Since 1987 , we have evaluated carboplatin alone or in combination with etoposide in two separate phase II trials of patients with non-small cell lung cancer ( NSCLC ) who had not received prior chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","etoposide"],"drug_indices_start":[31,72],"drug_indices_end":[42,81]}
{"index":1014,"text":"Oral formulations of paclitaxel and docetaxel are of great interest , but have yet to receive regulatory approval in this disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","docetaxel"],"drug_indices_start":[21,36],"drug_indices_end":[31,45]}
{"index":1015,"text":"FLAIE ( fludarabine , cytarabine , idarubicin , and etoposide ) , a four drug induction chemotherapy for adult acute myeloid leukemia : A single center experience .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","cytarabine","idarubicin","etoposide"],"drug_indices_start":[8,22,35,52],"drug_indices_end":[19,32,45,61]}
{"index":1016,"text":"Overall , our study shows that the combination of dabrafenib and cetuximab results in increased antitumor activity and decreased stem cell capacities in BRAF(V600E)-mutant CRC cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dabrafenib","cetuximab"],"drug_indices_start":[50,65],"drug_indices_end":[60,74]}
{"index":1017,"text":"Forty-seven patients with previously untreated metastatic or unresectable colorectal adenocarcinoma received capecitabine 1000 mg\/m2 twice daily on days 2 - 15 and intravenous irinotecan 100 mg\/m2 on days 1 and 8 , every 21 days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","irinotecan"],"drug_indices_start":[109,176],"drug_indices_end":[121,186]}
{"index":1018,"text":"Amphotericin B plus flucytosine were initially given to 4 patients , all of them developed liver and renal abnormalities to some degree after therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Amphotericin","flucytosine"],"drug_indices_start":[0,20],"drug_indices_end":[12,31]}
{"index":1019,"text":"Liposomes were surface modified with transferrin ( Tf ) for receptor targeting , and cell penetrating peptide PFVYLI ( PFV ) to increase translocation of doxorubicin ( Dox ) and Erlotinib ( Erlo ) across the BBB into glioblastoma ( U87 ) tumor cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","Erlotinib"],"drug_indices_start":[154,178],"drug_indices_end":[165,187]}
{"index":1020,"text":"Endpoints were determination of maximum tolerated dose of doxorubicin and etoposide , treatment tolerability , and survival .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[58,74],"drug_indices_end":[69,83]}
{"index":1021,"text":"Multiple ongoing clinical trials are currently evaluating the role of immune checkpoint inhibitors in ACC ( pembrolizumab , combination pembrolizumab and relacorilant , nivolumab , combination nivolumab and ipilimumab ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pembrolizumab","pembrolizumab","relacorilant","nivolumab","nivolumab","ipilimumab"],"drug_indices_start":[108,136,154,169,193,207],"drug_indices_end":[121,149,166,178,202,217]}
{"index":1022,"text":"Treatments including the monoclonal antibodies showed a cost per month of PFS gained of 2823 \u20ac ( FOLFIRI with cetuximab in KRAS wild-type patients and liver-only metastases ) , of \u20ac 15,822 ( FOLFOX with panitumumab in KRAS wild type ) , and of 13,383 \u20ac ( FOLFOX with bevacizumab ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","panitumumab","bevacizumab"],"drug_indices_start":[110,203,267],"drug_indices_end":[119,214,278]}
{"index":1024,"text":"In this study , combined drug action from the combination of Oxa with the phytochemicals andrographolide ( Andro ) , epigallocatechin-3-gallate ( EGCG ) , chlorophyllin ( Chl ) , colchicines ( Col ) , curcumin ( Cur ) and paclitaxel ( Tax ) was evaluated in the human ovarian cancer cell lines A2780 and A2780(cisR ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["curcumin","paclitaxel"],"drug_indices_start":[201,222],"drug_indices_end":[209,232]}
{"index":1025,"text":"Bevacizumab and intetumumab can be administered safely in combination .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Bevacizumab","intetumumab"],"drug_indices_start":[0,16],"drug_indices_end":[11,27]}
{"index":1026,"text":"The key findings were that amsacrine produced comparable levels of cell killing with both alpha and beta , whilst etoposide , doxorubicin and mitoxantrone produced higher degrees of cell killing with alpha than with beta or yeast topoisomerase II .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amsacrine","etoposide","doxorubicin","mitoxantrone"],"drug_indices_start":[27,114,126,142],"drug_indices_end":[36,123,137,154]}
{"index":1027,"text":"In the full study population , there were significant improvements in the anastrozole group compared with the tamoxifen group for disease-free survival ( hazard ratio [ HR ] 0\u00b791 , 95 % CI 0\u00b783 - 0\u00b799 ; p=0\u00b704 ) , time to recurrence ( 0\u00b784 , 0\u00b775 - 0\u00b793 ; p=0\u00b7001 ) , and time to distant recurrence ( 0\u00b787 , 0\u00b777 - 0\u00b799 ; p=0\u00b703 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","tamoxifen"],"drug_indices_start":[74,110],"drug_indices_end":[85,119]}
{"index":1028,"text":"The optimal correlation coefficients for norfloxacin , enrofloxacin , and ofloxacin in the prediction set were obtained with multiple linear regression that combined absorption peaks with wavelengths selected by stepwise regression , which were 0.867 , 0.828 , and 0.964 , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["norfloxacin","enrofloxacin","ofloxacin"],"drug_indices_start":[41,55,74],"drug_indices_end":[52,67,83]}
{"index":1029,"text":"The protocol consisted of oral gefitinib 250 mg daily for 1 year plus intravenous oxaliplatin 85 or 100 mg\/m(2 ) on days 1 , 15 , and 29 , and RT ( 50.4 Gy in 28 1.8-Gy fractions ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","oxaliplatin"],"drug_indices_start":[31,82],"drug_indices_end":[40,93]}
{"index":1030,"text":"The efflux curves observed for both verapamil and prochlorperazine could be mathematically modeled by assuming","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","prochlorperazine"],"drug_indices_start":[36,50],"drug_indices_end":[45,66]}
{"index":1031,"text":"The in vitro concentration-effect relationships for , chloroquine , mefloquine , lumefantrine and artesunate , were derived from clinical isolates obtained from patients on the western border of Thailand .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","mefloquine","lumefantrine","artesunate"],"drug_indices_start":[54,68,81,98],"drug_indices_end":[65,78,93,108]}
{"index":1032,"text":"Forty-eight patients were treated with mitoxantrone alone , 40 with mitoxantrone plus beta-interferon , 11 with fluorouracil plus folinic acid and the remaining four with adriamycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitoxantrone","mitoxantrone","fluorouracil","folinic acid","beta-interferon"],"drug_indices_start":[39,68,86,112,130],"drug_indices_end":[51,80,101,124,142]}
{"index":1033,"text":"Fifty-one HIV-negative patients with an average age of 50.3 years were treated with chemotherapy regimen included 2500 mg\/m(2 ) MTX with Leucovorin rescue and 1.4 mg\/m(2 ) vincristine ( day two ) , which was administered every other week for 6 weeks .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Leucovorin","vincristine"],"drug_indices_start":[137,172],"drug_indices_end":[147,183]}
{"index":1034,"text":"Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors : a Children 's Oncology Group study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["decitabine","doxorubicin","cyclophosphamide"],"drug_indices_start":[17,33,49],"drug_indices_end":[27,44,65]}
{"index":1035,"text":"Tail-flick test showed that tramadol produced better antinociceptive effect than gabapentin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tramadol","gabapentin"],"drug_indices_start":[28,81],"drug_indices_end":[36,91]}
{"index":1036,"text":"Our study involves a preliminary phase II trial , which evaluates the activity , feasibility and tolerability of a sequential combination of docetaxel and gemcitabine followed by docetaxel and carboplatin , as first-line treatment for inoperable NSCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","gemcitabine","docetaxel","carboplatin"],"drug_indices_start":[141,155,179,193],"drug_indices_end":[150,166,188,204]}
{"index":1037,"text":"The combination of galunisertib and sorafenib showed acceptable safety and a prolonged OS outcome .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["galunisertib","sorafenib"],"drug_indices_start":[19,36],"drug_indices_end":[31,45]}
{"index":1038,"text":"All the patients were conditioned with busulfan ( BU ) 12 mg.kg-1 and cyclophosphamide ( CY ) 3.6 g.m-2 , of whom 4 were conditioned with additioned antithymocyte globulin(ATG ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["busulfan","cyclophosphamide","antithymocyte globulin(ATG"],"drug_indices_start":[39,70,149],"drug_indices_end":[47,86,175]}
{"index":1039,"text":"Phase II study of an intensive combination chemotherapy with cisplatin , adriamycin , etoposide and cyclophosphamide ( CAVE ) in small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","adriamycin","etoposide","cyclophosphamide"],"drug_indices_start":[61,73,86,100],"drug_indices_end":[70,83,95,116]}
{"index":1040,"text":"These trials were compared with a broader set of trials examining the effectiveness of other AADs for AF : amiodarone , sotalol and class 1c agents ( flecainide and propafenone ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amiodarone","sotalol","flecainide","propafenone"],"drug_indices_start":[107,120,150,165],"drug_indices_end":[117,127,160,176]}
{"index":1041,"text":"First-line PFS for sorafenib , sunitinib , temsirolimus , everolimus , and \" other \" was 6.9 , 8.9 , 4.2 , not analyzed ( too few patients ) , and 10.8 months , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","sunitinib","temsirolimus","everolimus"],"drug_indices_start":[19,31,43,58],"drug_indices_end":[28,40,55,68]}
{"index":1042,"text":"Simultaneous treatment with gefitinib and pemetrexed enhanced cell growth inhibition and cell death and prevented the appearance of gefitinib resistance mediated by T790 M mutation or epithelial-to-mesenchymal transition ( EMT ) in PC9 and HCC827 cells , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","pemetrexed","gefitinib"],"drug_indices_start":[28,42,132],"drug_indices_end":[37,52,141]}
{"index":1043,"text":"Two courses of eight drugs in 1 day followed by two courses of etoposide plus carboplatin ( 500 and 800 mg\/m(2 ) per course , respectively ) were administered after surgery .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","carboplatin"],"drug_indices_start":[63,78],"drug_indices_end":[72,89]}
{"index":1044,"text":"Azithromycin , doxycycline , and moxifloxacin hydrochloride were shown to relieve symptoms but were not as effective after continuous usage .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Azithromycin","doxycycline","moxifloxacin"],"drug_indices_start":[0,15,33],"drug_indices_end":[12,26,45]}
{"index":1045,"text":"Travellers used doxycycline ( 15 % ) for malaria prophylaxis , 11 % took an antibiotic for travellers ' diarrhoea ( TD ) treatment ( fluoroquinolone 7 % , azithromycin 4 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxycycline","azithromycin"],"drug_indices_start":[16,155],"drug_indices_end":[27,167]}
{"index":1046,"text":"3 . When timolol was administered concomitantly with hydrochlorothiazide , plasma renin activity was suppressed and blood pressure was significantly lowered .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["timolol","hydrochlorothiazide"],"drug_indices_start":[9,53],"drug_indices_end":[16,72]}
{"index":1047,"text":"Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["temsirolimus","sunitinib"],"drug_indices_start":[39,56],"drug_indices_end":[51,65]}
{"index":1048,"text":"Both anastrozole ( 1.0 mg\/d ) and letrozole ( 2.5 mg\/d ) have now been approved as second-line treatment for hormone-dependent breast cancer in postmenopausal women in whom disease has progressed following tamoxifen treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","letrozole","tamoxifen"],"drug_indices_start":[5,34,206],"drug_indices_end":[16,43,215]}
{"index":1049,"text":"P-glycoprotein effluxes a variety of anticancer drugs , such as doxorubicin , vinca alkaloids , etoposide and taxol , and thereby allows cancer cells to show resistance to these drugs .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[64,96],"drug_indices_end":[75,105]}
{"index":1050,"text":"The H2-receptor antagonists dose-dependently inhibited the histamine-stimulated acid production ( IC50 for cimetidine = 10(-5 ) M and 10(-6 ) M and for ranitidine = 10(-5 ) M and 2 X 10(-7 ) M for high and low concentrations of histamine , respectively ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cimetidine","ranitidine"],"drug_indices_start":[107,152],"drug_indices_end":[117,162]}
{"index":1051,"text":"To examine the cost-effectiveness of aripiprazole , quetiapine , and olanzapine\/fluoxetine in adults with MDD who are refractory to antidepressant therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aripiprazole","quetiapine"],"drug_indices_start":[37,52],"drug_indices_end":[49,62]}
{"index":1052,"text":"2 . The two combination treatment regimes lowered the 12 h post-dose blood pressure more effectively than did atenolol alone , but the high dose nifedipine combination was no more effective than the low dose nifedipine combination .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atenolol","nifedipine","nifedipine"],"drug_indices_start":[110,145,208],"drug_indices_end":[118,155,218]}
{"index":1053,"text":"In addition , a variety of systemic chemotherapeutic agents have been tested in HCC , including various combinations of 5-fluorouracil , doxorubicin , epirubicin , etoposide , cisplatin , and mitoxantrone , as well as interferon , tamoxifen , capecitabine , thalidomide , and octreotide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","epirubicin","etoposide","cisplatin","mitoxantrone","tamoxifen","capecitabine","thalidomide","octreotide"],"drug_indices_start":[137,151,164,176,192,231,243,258,276],"drug_indices_end":[148,161,173,185,204,240,255,269,286]}
{"index":1054,"text":"A very reasonable first-choice antidepressant is either sertraline or paroxetine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sertraline","paroxetine"],"drug_indices_start":[56,70],"drug_indices_end":[66,80]}
{"index":1055,"text":"It is concluded that plasma lipid regulators which elevate HDL in this model might do so by altering the metabolism and hence plasma concentration of apoAI ( fenofibrate , ciprofibrate ) or both apo E and A-I ( gemfibrozil ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fenofibrate","ciprofibrate","gemfibrozil"],"drug_indices_start":[158,172,211],"drug_indices_end":[169,184,222]}
{"index":1056,"text":"To evaluate the effect of switching to bevacizumab or ranibizumab after developing tachyphylaxis during anti-vascular endothelial growth factor ( VEGF ) therapy for choroidal neovascularisation ( CNV ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","ranibizumab"],"drug_indices_start":[39,54],"drug_indices_end":[50,65]}
{"index":1057,"text":"Low-risk patients received three cycles of modified CODOX-M ( cyclophosphamide , doxorubicin , adriamycin , vincristine with intrathecal methotrexate and cytarabine followed by high-dose systemic methotrexate , regimen A ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","vincristine","methotrexate","cytarabine","methotrexate","adriamycin"],"drug_indices_start":[62,81,95,108,137,154,196],"drug_indices_end":[78,92,105,119,149,164,208]}
{"index":1058,"text":"Background The National Wilms Tumor Study ( NWTS ) approach to treating stage III favorable-histology Wilms tumor ( FHWT ) is Regimen DD4A ( vincristine , dactinomycin , and doxorubicin ) and radiation therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","doxorubicin","dactinomycin"],"drug_indices_start":[141,155,174],"drug_indices_end":[152,167,185]}
{"index":1059,"text":"The role of serotonergic neurons in foot shock-induced jumping behavior was evaluated by studying the effects of serotonin agonists and depletors under conditions of increasing activity of catecholaminergic neurons by combining different shock intensities with methamphetamine or clonidine pretreatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methamphetamine","clonidine"],"drug_indices_start":[261,280],"drug_indices_end":[276,289]}
{"index":1060,"text":"Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["leuprolide","bicalutamide"],"drug_indices_start":[46,91],"drug_indices_end":[56,103]}
{"index":1061,"text":"Clinical studies have indicated the following relative potency differences : fluticasone propionate > budesonide = beclomethasone dipropionate > triamcinolone acetonide = flunisolide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluticasone","budesonide","beclomethasone","triamcinolone"],"drug_indices_start":[77,102,115,145],"drug_indices_end":[88,112,129,158]}
{"index":1062,"text":"To evaluate the efficacy and safety of lapatinib ( L ) and trastuzumab ( T ) combination in HER2-positive metastatic breast cancer ( MBC ) patients previously treated with T and\/or L.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","trastuzumab"],"drug_indices_start":[39,59],"drug_indices_end":[48,70]}
{"index":1063,"text":"Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Meloxicam","sorafenib"],"drug_indices_start":[0,24],"drug_indices_end":[9,33]}
{"index":1064,"text":"We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy ( E2997 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","cyclophosphamide"],"drug_indices_start":[109,171],"drug_indices_end":[120,187]}
{"index":1065,"text":"The antiviral agents ganciclovir and foscarnet are effective against CMV retinitis and gastrointestinal diseases , although dose-limiting adverse effects and the need for long-term maintenance therapy may hinder their use in many patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ganciclovir","foscarnet"],"drug_indices_start":[21,37],"drug_indices_end":[32,46]}
{"index":1066,"text":"Switching between metronidazole and clarithromycin seems to be a sensible strategy as these two are the most effective anti-Helicobacter agents .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metronidazole","clarithromycin"],"drug_indices_start":[18,36],"drug_indices_end":[31,50]}
{"index":1067,"text":"Therefore , downregulation of bcl-2 or xIAP by RNAi enhances the effects of etoposide and doxorubicin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin"],"drug_indices_start":[76,90],"drug_indices_end":[85,101]}
{"index":1068,"text":"Cetuximab is a monoclonal antibody against EGFR with additive preclinical activity with irinotecan .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cetuximab","irinotecan"],"drug_indices_start":[0,88],"drug_indices_end":[9,98]}
{"index":1070,"text":"Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","temozolomide"],"drug_indices_start":[12,27],"drug_indices_end":[22,39]}
{"index":1071,"text":"This is a phase II study of etoposide , vincristine , and doxorubicin , administered as a 96-hour continuous infusion , with intravenous ( IV ) bolus cyclophosphamide and oral prednisone ( EPOCH ) in 74 consecutive patients who relapsed from or failed to respond to most of the same drugs administered on a bolus schedule .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","vincristine","doxorubicin","cyclophosphamide","prednisone"],"drug_indices_start":[28,40,58,150,176],"drug_indices_end":[37,51,69,166,186]}
{"index":1072,"text":"Based on the FIRM-ACT trial , mitotane plus etoposide , doxorubicin , and cisplatin is now the established first-line cytotoxic therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitotane","etoposide","doxorubicin","cisplatin"],"drug_indices_start":[30,44,56,74],"drug_indices_end":[38,53,67,83]}
{"index":1073,"text":"Additionally , thorough analysis of the available literature indicates no correlation between dasatinib nor nilotinib dose , length of exposure , trimester of use , and deleterious patient or fetal outcomes can be concluded .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dasatinib","nilotinib"],"drug_indices_start":[94,108],"drug_indices_end":[103,117]}
{"index":1074,"text":"The principal toxicity was myelosuppression ; grade 4 neutropenia was more frequent with topotecan ( 81.4 % of patients ) than with paclitaxel ( 22.9 % of patients ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["topotecan","paclitaxel"],"drug_indices_start":[89,132],"drug_indices_end":[98,142]}
{"index":1075,"text":"Consistent with previous reports , genistein combined with doxorubicin had a synergistic effect on MCF-7\/Adr cells , and genistein reduced the chemoresistance of these cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["genistein","doxorubicin","genistein"],"drug_indices_start":[35,59,121],"drug_indices_end":[44,70,130]}
{"index":1076,"text":"This historical cohort study evaluated the association of efavirenz ( EFV ) compared to nevirapine ( NVP ) with post-ART TB among patients initiated on first-line ART from 2005 to 2009 in a large , urban HIV clinic in Uganda .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["efavirenz","nevirapine"],"drug_indices_start":[58,88],"drug_indices_end":[67,98]}
{"index":1077,"text":"Combination of ibrutinib and ublituximab ( n = 64 ) had an ORR of 78 % ( CR 7 % ) in a phase 3 study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ibrutinib","ublituximab"],"drug_indices_start":[15,29],"drug_indices_end":[24,40]}
{"index":1079,"text":"This review therefore aims to overview the prognostic value of MRD eradication in CLL , the role of post-remission intervention with \" passive \" immunotherapy ( alemtuzumab or rituximab ) so as to eliminate persistent MRD or prevent MRD relapse , the impact of these strategies on disease-free survival and their possible adverse consequences .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["alemtuzumab","rituximab"],"drug_indices_start":[161,176],"drug_indices_end":[172,185]}
{"index":1080,"text":"Paclitaxel , 5-fluorouracil , hydroxyurea , and concomitant radiation therapy for poor-prognosis head and neck cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","5-fluorouracil","hydroxyurea"],"drug_indices_start":[0,13,30],"drug_indices_end":[10,27,41]}
{"index":1082,"text":"Clonogenic assays showed that preexposure to hypoxia leads to resistance to various classes of chemotherapeutic agents , including anthracyclines ( daunorubicin and doxorubicin ) , epipodophyllotoxins ( etoposide ) , and anthracenediones ( mitoxantrone ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["daunorubicin","doxorubicin","etoposide","mitoxantrone"],"drug_indices_start":[148,165,203,240],"drug_indices_end":[160,176,212,252]}
{"index":1083,"text":"Hence , the aim of this study was to conduct an economic evaluation of anastrozole versus tamoxifen in early stage breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["anastrozole","tamoxifen"],"drug_indices_start":[71,90],"drug_indices_end":[82,99]}
{"index":1084,"text":"A randomized trial of mobilization of peripheral blood stem cells with cyclophosphamide , etoposide , and granulocyte colony-stimulating factor with or without cisplatin in patients with malignant lymphoma receiving high-dose chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","etoposide","cisplatin"],"drug_indices_start":[71,90,160],"drug_indices_end":[87,99,169]}
{"index":1085,"text":"Treatment of pancreatic cancer with a combination of docetaxel , gemcitabine and granulocyte colony-stimulating factor : a phase II study of the Greek Cooperative Group for Pancreatic Cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","gemcitabine"],"drug_indices_start":[53,65],"drug_indices_end":[62,76]}
{"index":1086,"text":"Such situations are known as exposing to pneumococcal meningitis and to resistance of the strain involved to penicillin G. Both patients were cured by vancomycin in continuous infusion associated with rifampicin or fosfomycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vancomycin","rifampicin","fosfomycin"],"drug_indices_start":[151,201,215],"drug_indices_end":[161,211,225]}
{"index":1087,"text":"We recently identified a unique site within the MLL bcr that is highly susceptible to DNA double-strand cleavage by classic topo II inhibitors ( e.g. , etoposide and doxorubicin ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin"],"drug_indices_start":[152,166],"drug_indices_end":[161,177]}
{"index":1088,"text":"In 2011 , the combination of rituximab with bendamustine ( 31 % ) was most frequent used followed by the rituximab-fludarabine-cyclophosphamide ( 22 % ) regime .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","bendamustine"],"drug_indices_start":[29,44],"drug_indices_end":[38,56]}
{"index":1089,"text":"The combination of ofatumumab and bendamustine in elderly patients with diffuse large B-cell lymphoma demonstrated modest efficacy compared with standard of care .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ofatumumab","bendamustine"],"drug_indices_start":[19,34],"drug_indices_end":[29,46]}
{"index":1090,"text":"Imatinib and nilotinib directly inhibit the kinase activity of KIT , while RAD001 ( everolimus ) inhibits mTOR .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Imatinib","nilotinib","everolimus"],"drug_indices_start":[0,13,84],"drug_indices_end":[8,22,94]}
{"index":1091,"text":"In this study the antiproliferative effects of Paclitaxel ( PAC ) , Epirubicin ( EPI ) and Tamoxifen ( TAM ) on growth kinetics of Ehrlich Ascites Tumor ( EAT ) cells were examined in culture .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","Epirubicin","Tamoxifen"],"drug_indices_start":[47,68,91],"drug_indices_end":[57,78,100]}
{"index":1092,"text":"The most common chemotherapy and route of administration for systemic treatment is paclitaxel plus carboplatin given intravenously .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[83,99],"drug_indices_end":[93,110]}
{"index":1093,"text":"Finally , the ability of givinostat , belinostat and panobinostat to reactivate latent HIV-1 expression in primary T-cells was investigated employing a CCL19-induced latent primary CD4 + T cell infection model .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["belinostat","panobinostat"],"drug_indices_start":[38,53],"drug_indices_end":[48,65]}
{"index":1094,"text":"Aflibercept has been used in combination with folinic acid (leucovorin)-fluorouracil-irinotecan ( FOLFIRI ) chemotherapy in mCRC patients and among patients with mCRC with wild-type KRAS , the outcomes were significantly improved by panitumumab in combination with folinic acid (leucovorin)-fluorouracil-oxaliplatin ( FOLFOX ) or FOLFIRI .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aflibercept","folinic acid","panitumumab","folinic acid"],"drug_indices_start":[0,46,233,265],"drug_indices_end":[11,58,244,277]}
{"index":1095,"text":"The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","ifosfamide"],"drug_indices_start":[104,132],"drug_indices_end":[115,142]}
{"index":1096,"text":"All patients received intravenous heparin after PTCA and aspirin was begun on the day prior to PTCA .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["heparin","aspirin"],"drug_indices_start":[34,57],"drug_indices_end":[41,64]}
{"index":1098,"text":"After an initial 6 - 8 weeks of metformin , they received either letrozole ( 2.5 mg ) or clomiphene ( 100 mg ) from day 3 - 7 of their menstrual cycle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metformin","letrozole","clomiphene"],"drug_indices_start":[32,65,89],"drug_indices_end":[41,74,99]}
{"index":1099,"text":"No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab , etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( R-EPOCH ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","etoposide","prednisone","vincristine","cyclophosphamide","doxorubicin"],"drug_indices_start":[90,102,114,127,141,164],"drug_indices_end":[99,111,124,138,157,175]}
{"index":1100,"text":"Although MAPK\/ERK1\/2 kinase inhibitors ( MEKi ) are useful antitumor agents in a clinical setting , including the Food and Drug Administration (FDA)-approved MEK1,2 dual inhibitors cobimetinib and trametinib , there are limitations to their clinical utility , primarily adaptation of the BRAF pathway and ocular toxicities .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cobimetinib","trametinib"],"drug_indices_start":[181,197],"drug_indices_end":[192,207]}
{"index":1101,"text":"Suggested evidence linking the association of the drug to the event includes knowing that Panitumumab and Irinotecan can contribute to all other possible causes of cardiac arrest , temporal relationship and pharmacological time plausibility , and recognized association with the product or the class .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Panitumumab","Irinotecan"],"drug_indices_start":[90,106],"drug_indices_end":[101,116]}
{"index":1102,"text":"This study was designed to evaluate the effect of aprotinin on activated versus nonactivated whole blood clotting time using two different on-site methods and to quantify these anticoagulant properties when compared to heparin in a controlled , in vitro environment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aprotinin","heparin"],"drug_indices_start":[50,219],"drug_indices_end":[59,226]}
{"index":1103,"text":"Cyclophosphamide , mitoxantrone , fluorouracil versus conventional CMF as adjuvant treatment in node-positive breast cancer patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cyclophosphamide","mitoxantrone","fluorouracil"],"drug_indices_start":[0,19,34],"drug_indices_end":[16,31,46]}
{"index":1104,"text":"After the operation , an alternating vincristine , doxorubicin , and cyclophosphamide\/ifosfamide and etoposide ( IE ) regimen was given for eight cycles , and the patient survived for 66 mo without progression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","doxorubicin","etoposide"],"drug_indices_start":[37,51,101],"drug_indices_end":[48,62,110]}
{"index":1105,"text":"A total of 34 patients with androgen-independent prostate cancer received doxorubicin , 30 mg\/m(2 ) , every 2 weeks and ketoconazole daily , 400 mg orally every 8 hours .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","ketoconazole"],"drug_indices_start":[74,120],"drug_indices_end":[85,132]}
{"index":1106,"text":"All 35 patients were treated with the ANLL91 protocol consisting of etoposide , high-dose cytarabine , and anthracyclines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","cytarabine"],"drug_indices_start":[68,90],"drug_indices_end":[77,100]}
{"index":1107,"text":"Three first-line drugs are recommended , pegylated interferon alfa-2a , entecavir and tenofovir .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pegylated interferon alfa-2a","entecavir","tenofovir"],"drug_indices_start":[41,72,86],"drug_indices_end":[69,81,95]}
{"index":1108,"text":"Whereas fluoxetine showed the highest level of specificity , followed by citalopram and fluvoxamine , the effect of paroxetine was nonspecific .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluoxetine","citalopram","fluvoxamine","paroxetine"],"drug_indices_start":[8,73,88,116],"drug_indices_end":[18,83,99,126]}
{"index":1109,"text":"A countercurrent seepage bioreactor immobilized with Phanerochaete chrysosporium was continuously operated under non-sterile conditions to treat a synthetic wastewater spiked with naproxen and carbamazepine ( 1000\u03bcg\/L each ) for 165days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["naproxen","carbamazepine"],"drug_indices_start":[180,193],"drug_indices_end":[188,206]}
{"index":1110,"text":"A phase 1\/2 trial of tivozanib in combination with durvalumab is currently underway .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tivozanib","durvalumab"],"drug_indices_start":[21,51],"drug_indices_end":[30,61]}
{"index":1111,"text":"Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3 , randomized , controlled , BOLERO-2 trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["everolimus","exemestane","exemestane"],"drug_indices_start":[84,100,131],"drug_indices_end":[94,110,141]}
{"index":1112,"text":"Phase 2 study of irinotecan and paclitaxel in patients with recurrent or refractory small cell lung cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","paclitaxel"],"drug_indices_start":[17,32],"drug_indices_end":[27,42]}
{"index":1113,"text":"Administration of artesunate and artemether at a dose of 400mg\/kg to O. viverrini-infected hamsters resulted in worm burden reductions of 77.6 % and 65.5 % , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artesunate","artemether"],"drug_indices_start":[18,33],"drug_indices_end":[28,43]}
{"index":1115,"text":"This was a multicenter phase II pilot study of rituximab and modified hyper-fractionated cyclophosphamide , vincristine doxorubicin , dexamethasone ( modified R-hyperCVAD ) administered every 28 days for four to six cycles followed by rituximab maintenance therapy consisting of four weekly doses every 6 months for 2 years .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","cyclophosphamide","vincristine","doxorubicin","dexamethasone","rituximab"],"drug_indices_start":[47,89,108,120,134,235],"drug_indices_end":[56,105,119,131,147,244]}
{"index":1116,"text":"The first line of treatment is selective serotonin reuptake inhibitors ( dapoxetine , which is the only drug with an official label for this indication , paroxetine , sertraline , fluoxetine , citalopram , escitalopram ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dapoxetine","paroxetine","sertraline","fluoxetine","citalopram","escitalopram"],"drug_indices_start":[73,154,167,180,193,206],"drug_indices_end":[83,164,177,190,203,218]}
{"index":1117,"text":"This trial will close to accrual in September 1995 , and analysis of the trial should provide useful information regarding the potential synergy of doxorubicin and paclitaxel , the degree of cross-resistance between the two compounds , and the relationship between steady-state paclitaxel levels and response to therapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","paclitaxel","paclitaxel"],"drug_indices_start":[148,164,278],"drug_indices_end":[159,174,288]}
{"index":1118,"text":"Neither systolic nor diastolic BP during daytime differed between losartan and quinapril treatments , but those during nighttime were lower with losartan treatment than with quinapril treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["losartan","quinapril","losartan","quinapril"],"drug_indices_start":[66,79,145,174],"drug_indices_end":[74,88,153,183]}
{"index":1119,"text":"Ferrochloroquine was 35 times more active than chloroquine ( 35-fold greater against chloroquine-resistant isolates ) , quinine , mefloquine , amodiaquine , cycloguanil and pyrimethamine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","quinine","mefloquine","amodiaquine","pyrimethamine"],"drug_indices_start":[47,120,130,143,173],"drug_indices_end":[58,127,140,154,186]}
{"index":1120,"text":"26 patients received adjuvant chemotherapy ( carboplatin plus etoposide ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","etoposide"],"drug_indices_start":[45,62],"drug_indices_end":[56,71]}
{"index":1121,"text":"A concentration-dependent effect of venetoclax on PFS and a prolonged synergistic effect of 6 cycles of concomitant rituximab were identified .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["venetoclax","rituximab"],"drug_indices_start":[36,116],"drug_indices_end":[46,125]}
{"index":1122,"text":"Carboplatin plus taxanes are non-inferior to epirubicin plus cyclophosphamide followed by taxanes as adjuvant chemotherapy for early triple-negative breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Carboplatin","taxanes","epirubicin","cyclophosphamide"],"drug_indices_start":[0,17,45,61],"drug_indices_end":[11,24,55,77]}
{"index":1123,"text":"Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections : the efficacy , safety and effect on fecal flora .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ceftriaxone","cefuroxime","gentamicin"],"drug_indices_start":[21,77,93],"drug_indices_end":[32,87,103]}
{"index":1124,"text":"A phase 1b , dose escalation study was performed to assess maximum tolerated dose , safety\/toxicity , clinical efficacy and explored pharmacodynamic biomarkers of response to entinostat combined with lapatinib with or without trastuzumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["entinostat","lapatinib","trastuzumab"],"drug_indices_start":[175,200,226],"drug_indices_end":[185,209,237]}
{"index":1125,"text":"Objective and palliative effect of chemotherapy is marked for weekly doxorubicin , prednisone with mitoxantrone and etoposide associated with platin-salts for prostatic carcinoma with neuroendocrine differentiation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","prednisone","mitoxantrone","etoposide"],"drug_indices_start":[69,83,99,116],"drug_indices_end":[80,93,111,125]}
{"index":1126,"text":"The recommendations derived from the comprehensive assessment of the literature and guidelines are to continue NSAIDs and low dose aspirin , and phosphodiesterase inhibitors ( dipyridamole , cilostazol , Aggrenox ) during interventional techniques .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","dipyridamole","cilostazol"],"drug_indices_start":[131,176,191],"drug_indices_end":[138,188,201]}
{"index":1127,"text":"Enhanced growth-inhibiting effects were also observed in HCC cells treated with a combination of sorafenib and silibinin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","silibinin"],"drug_indices_start":[97,111],"drug_indices_end":[106,120]}
{"index":1128,"text":"The effects of the Acanthopanax obovatus polysaccharide ( AOPS ) as well as its combination with cyclophosphamide ( CY ) or prednisolone on immune responses were investigated in mice .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Acanthopanax obovatus polysaccharide","cyclophosphamide","prednisolone"],"drug_indices_start":[19,97,124],"drug_indices_end":[55,113,136]}
{"index":1129,"text":"We did the QuiRedex study to compare early treatment with lenalidomide plus dexamethasone with observation in patients with high-risk smouldering multiple myeloma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lenalidomide","dexamethasone"],"drug_indices_start":[58,76],"drug_indices_end":[70,89]}
{"index":1131,"text":"Tissue from preclinical models and patients ' biopsies were collected pre-treatment and on Cycle ( C ) 1 , Day ( D ) 9 to characterize the effect of gemcitabine and salirasib on activated Ras protein levels .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","salirasib"],"drug_indices_start":[149,165],"drug_indices_end":[160,174]}
{"index":1132,"text":"An isocratic liquid chromatographic method with UV detection at 210 nm is described for simultaneous determination of amoxicillin sodium and sulbactam sodium in a new combination formulation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amoxicillin","sulbactam"],"drug_indices_start":[118,141],"drug_indices_end":[129,150]}
{"index":1133,"text":"The difference in inhibitory potency of parent drugs and metabolites was higher for halofantrine than for mefloquine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["halofantrine","mefloquine"],"drug_indices_start":[84,106],"drug_indices_end":[96,116]}
{"index":1134,"text":"In total , 417 patients were included : 312 ( 74\u00b78 % ) received vancomycin and 105 ( 25\u00b72 % ) received daptomycin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vancomycin","daptomycin"],"drug_indices_start":[64,103],"drug_indices_end":[74,113]}
{"index":1135,"text":"The effect of dasatinib , an inhibitor of Src and Abl kinases , on paclitaxel sensitivity was measured in ovarian cancer cells and HEY xenografts .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dasatinib","paclitaxel"],"drug_indices_start":[14,67],"drug_indices_end":[23,77]}
{"index":1136,"text":"The maximum tolerated dose ( MTD ) was 20 mg\/m2\/day I.V. bolus for 5 days of fludarabine plus 60 mg\/m2\/day I.V. of paclitaxel given as a continuous infusion over 72 hours .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","paclitaxel"],"drug_indices_start":[77,115],"drug_indices_end":[88,125]}
{"index":1137,"text":"Further studies are needed to identify predictors of response and toxicity to this approach , as well as the optimal scheduling of ipilimumab with maintenance nivolumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ipilimumab","nivolumab"],"drug_indices_start":[131,159],"drug_indices_end":[141,168]}
{"index":1138,"text":"Efficacy of palonosetron plus aprepitant in preventing chemoradiotherapy-induced nausea and emesis in patients receiving daily low-dose cisplatin-based concurrent chemoradiotherapy for uterine cervical cancer : a phase II study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["palonosetron","aprepitant"],"drug_indices_start":[12,30],"drug_indices_end":[24,40]}
{"index":1140,"text":"was lowest in the propofol + dexmedetomidine group ( all , P < 0.05 ) , and the AUC of pulse oximetry was significantly higher in the propofol + dexmedetomidine and propofol + ketamine groups compared to the other 2 groups ( both , P < 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propofol","dexmedetomidine","propofol","dexmedetomidine","propofol","ketamine"],"drug_indices_start":[18,29,134,145,165,176],"drug_indices_end":[26,44,142,160,173,184]}
{"index":1141,"text":"Ethosuximide primarily acts by blocking T-type voltage-gated calcium channels in thalamic neurones while topiramate and zonisamide have multiple mechanisms of action .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ethosuximide","topiramate","zonisamide"],"drug_indices_start":[0,105,120],"drug_indices_end":[12,115,130]}
{"index":1143,"text":"Therefore , if a combination regimen is necessary to control CMV in a patient , foscarnet and ganciclovir should be used first .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["foscarnet","ganciclovir"],"drug_indices_start":[80,94],"drug_indices_end":[89,105]}
{"index":1144,"text":"A Phase Ib\/II Study of Afatinib in Combination with Nimotuzumab in Non-Small Cell Lung Cancer Patients with Acquired Resistance to Gefitinib or Erlotinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Afatinib","Nimotuzumab","Gefitinib","Erlotinib"],"drug_indices_start":[23,52,131,144],"drug_indices_end":[31,63,140,153]}
{"index":1146,"text":"Two model drugs , omeprazole and verapamil , were used to test the integrated model .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["omeprazole","verapamil"],"drug_indices_start":[18,33],"drug_indices_end":[28,42]}
{"index":1147,"text":"This study analysed 126 patients with relapsed , advanced stage follicular lymphoma who received BEAM ( BCNU [ carmustine ] , cytarabine , etoposide , melphalan)-alemtuzumab allogeneic HSCT ( BEAM-allo ) ( n = 44 ) or BEAM-autologous HSCT ( BEAM-auto ) ( n = 82 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carmustine","cytarabine","etoposide","melphalan)-alemtuzumab"],"drug_indices_start":[111,126,139,151],"drug_indices_end":[121,136,148,173]}
{"index":1148,"text":"Apixaban and rivaroxaban were evaluated in phase III trials for prevention of recurrent ischaemia in ACS patients , most of whom were also receiving dual antiplatelet therapy with aspirin and clopidogrel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Apixaban","rivaroxaban","aspirin","clopidogrel"],"drug_indices_start":[0,13,180,192],"drug_indices_end":[8,24,187,203]}
{"index":1149,"text":"Systemic and local effects of lidocaine or mepivacaine when used for intravenous regional anaesthesia of the distal limb in standing sedated horses .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lidocaine","mepivacaine"],"drug_indices_start":[30,43],"drug_indices_end":[39,54]}
{"index":1150,"text":"These 18 TMP-resistant E. coli were also resistant to ampicillin ( 44 % ) , azithromycin ( 11 % ) , chloramphenicol ( 39 % ) , ciprofloxacin ( 11 % ) , doxycycline ( 89 % ) , erythromycin ( 100 % ) , furazolidone ( 72 % ) , levofloxacin ( 17 % ) , trimethoprim-sulfamethoxazole ( 89 % ) and trovafloxacin ( 17 % ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","azithromycin","chloramphenicol","ciprofloxacin","doxycycline","erythromycin","furazolidone","levofloxacin"],"drug_indices_start":[54,76,100,127,152,175,200,224],"drug_indices_end":[64,88,115,140,163,187,212,236]}
{"index":1151,"text":"Furthermore , VPA significantly increased chemosensitivity to fludarabine , flavopiridol , bortezomib , thalidomide and lenalidomide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["VPA","fludarabine","flavopiridol","bortezomib","thalidomide","lenalidomide"],"drug_indices_start":[14,62,76,91,104,120],"drug_indices_end":[17,73,88,101,115,132]}
{"index":1152,"text":"Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab , trastuzumab , and docetaxel for advanced HER2-positive breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertuzumab","trastuzumab","docetaxel"],"drug_indices_start":[122,135,153],"drug_indices_end":[132,146,162]}
{"index":1153,"text":"The clinical symptoms were relieved after combination of doxycycline , rifampicin , levofloxacin and amikacin for 6 weeks , only one patient with bone destruction needed orthopedic surgery .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxycycline","rifampicin","levofloxacin","amikacin"],"drug_indices_start":[57,71,84,101],"drug_indices_end":[68,81,96,109]}
{"index":1154,"text":"Validated LC-MS\/MS method for the simultaneous determination of enalapril maleate , nitrendipine , hydrochlorothiazide , and their major metabolites in human plasma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enalapril","nitrendipine","hydrochlorothiazide"],"drug_indices_start":[64,84,99],"drug_indices_end":[73,96,118]}
{"index":1155,"text":"Four years after surgery , she experienced a recurrence of breast cancer in the thoracic wall , and was treated with exemestane , toremifene , and fulvestrant for 1 year and 5 months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["exemestane","toremifene","fulvestrant"],"drug_indices_start":[117,130,147],"drug_indices_end":[127,140,158]}
{"index":1156,"text":"Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxazosin","atenolol"],"drug_indices_start":[22,37],"drug_indices_end":[31,45]}
{"index":1157,"text":"To evaluate the use of low-molecular-weight heparin ( LMWH ) in combination with low-dose aspirin ( LDA ) for the treatment of antiphospholipid antibody (APA)-associated recurrent pregnancy loss and to compare the results with the use of unfractionated heparin ( UFH ) plus LDA .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["low-molecular-weight heparin","aspirin","unfractionated heparin"],"drug_indices_start":[23,90,238],"drug_indices_end":[51,97,260]}
{"index":1158,"text":"Therefore , the pain scores were significantly higher in the neostigmine group than the other two groups ( p = 0.02 ) , but no significant difference was found between the two groups that received dexmedetomidine and a combination of dexmedetomidine + neostigmine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["neostigmine","dexmedetomidine","dexmedetomidine","neostigmine"],"drug_indices_start":[61,197,234,252],"drug_indices_end":[72,212,249,263]}
{"index":1159,"text":"[ Two cases of complete response to combination chemotherapy of gemcitabine and docetaxel for recurrent ovarian cancer ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","docetaxel"],"drug_indices_start":[64,80],"drug_indices_end":[75,89]}
{"index":1160,"text":"Hormonal changes in postmenopausal women with breast cancer treated with trilostane and dexamethasone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trilostane","dexamethasone"],"drug_indices_start":[73,88],"drug_indices_end":[83,101]}
{"index":1161,"text":"After surgical insertion of a catheter in the hepatic artery , patients were treated with oxaliplatin 100 mg\/m(2 ) HAI combined with FU + leucovorin IV according to the LV5FU2 protocol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxaliplatin","leucovorin"],"drug_indices_start":[90,138],"drug_indices_end":[101,148]}
{"index":1162,"text":"Furthermore methysergide ( 10 mg\/kg i.p . ) , but not muscimol ( 2 mg\/kg i.p . ) elicited jumping behavior when combined with clonidine ( 0.5 mg\/kg i.p . ) , TRH ( 20 mg\/kg i.p . ) , haloperidol ( 4 mg\/kg i.p . ) or atropine ( 5 mg\/kg i.p . ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methysergide","clonidine","haloperidol","atropine"],"drug_indices_start":[12,126,183,216],"drug_indices_end":[24,135,194,224]}
{"index":1163,"text":"Then , doxorubicin with or without flavopiridol was injected .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","flavopiridol"],"drug_indices_start":[7,35],"drug_indices_end":[18,47]}
{"index":1164,"text":"Subjects were treated in two cycles , 3 months apart , in which they received bicalutamide 150 mg daily days 1 - 28 and tremelimumab on day 29 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bicalutamide","tremelimumab"],"drug_indices_start":[78,120],"drug_indices_end":[90,132]}
{"index":1165,"text":"In the search better tumoral response in the treatment of epithelial ovarian cancer new drugs have surged that promise good results , including docetaxel , topotecan and gemcitabine ,","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","topotecan","gemcitabine"],"drug_indices_start":[144,156,170],"drug_indices_end":[153,165,181]}
{"index":1166,"text":"This study examines a novel regimen utilizing the combination of epidurally infused ropivacaine - hydromorphone and scheduled ketorolac .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ropivacaine","hydromorphone","ketorolac"],"drug_indices_start":[84,98,126],"drug_indices_end":[95,111,135]}
{"index":1168,"text":"Patients in the HXP arm also received trastuzumab ( 8 mg\/kg intravenous infusion on Day 1 ) , concurrently with capecitabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trastuzumab","capecitabine"],"drug_indices_start":[38,112],"drug_indices_end":[49,124]}
{"index":1169,"text":"Among targeted therapies , lapatinib has activity in systemic treatment of BM particularly when used in combination with capecitabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","capecitabine"],"drug_indices_start":[27,121],"drug_indices_end":[36,133]}
{"index":1170,"text":"Anaemia was present in patients who had just been diagnosed with rheumatoid arthritis and had never taken disease modifying agents or biologicals ( non-specific therapy group ) , but not in those taking either leflunomide or adalimumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["leflunomide","adalimumab"],"drug_indices_start":[210,225],"drug_indices_end":[221,235]}
{"index":1172,"text":"The Society of Critical Care Medicine ( SCCM ) released updated guidelines for management of pain , agitation , and delirium in the ICU and recommended nonbenzodiazepines , such as dexmedetomidine and propofol , as first line sedation agents .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexmedetomidine","propofol"],"drug_indices_start":[181,201],"drug_indices_end":[196,209]}
{"index":1173,"text":"An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","gentamicin"],"drug_indices_start":[26,59],"drug_indices_end":[38,69]}
{"index":1174,"text":"Among antimicrobials , ciprofloxacin ( 22 ( 22.7 % ) ) was the most common drug followed by metronidazole ( 21 ( 18.5 % ) ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ciprofloxacin","metronidazole"],"drug_indices_start":[23,92],"drug_indices_end":[36,105]}
{"index":1175,"text":"Clinical efficacy of immunochemotherapy with rituximab , fludarabine and mitoxantrone followed by 2-monthly rituximab maintenance was evaluated in 29 patients with previously untreated follicular lymphoma in a prospective phase II trial ( AGMT-NHL9 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","fludarabine","mitoxantrone","rituximab"],"drug_indices_start":[45,57,73,108],"drug_indices_end":[54,68,85,117]}
{"index":1176,"text":"Palliative chemotherapy with carboplatin and etoposide produced a minimal response .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","etoposide"],"drug_indices_start":[29,45],"drug_indices_end":[40,54]}
{"index":1177,"text":"In vitro susceptibilities of ocular Bacillus cereus isolates to clindamycin , gentamicin , and vancomycin alone or in combination .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clindamycin","gentamicin","vancomycin"],"drug_indices_start":[64,78,95],"drug_indices_end":[75,88,105]}
{"index":1178,"text":"Most ( \u2265 75 % ) patients received ESHAP ( etoposide , methylprednisolone , cytarabine , cisplatin ) or DHAP ( cisplatin , cytosine arabinoside , dexamethasone ) as salvage chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","methylprednisolone","cytarabine","cisplatin","cisplatin","cytosine arabinoside","dexamethasone"],"drug_indices_start":[42,54,75,88,110,122,145],"drug_indices_end":[51,72,85,97,119,142,158]}
{"index":1179,"text":"Patients treated on CCG-3881 ( n = 116 ) received four-drug chemotherapy for 9 months ( cisplatin , cyclophosphamide , doxorubicin , and etoposide ) , with surgery and local radiation to residual disease .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","cyclophosphamide","doxorubicin","etoposide"],"drug_indices_start":[88,100,119,137],"drug_indices_end":[97,116,130,146]}
{"index":1180,"text":"184 ( 62\u00b70 % , 95 % CI 56\u00b72 - 67\u00b75 ) patients in the cetuximab group achieved an objective response compared with 171 ( 58\u00b70 % , 52\u00b71 - 63\u00b77 ) in the bevacizumab group ( odds ratio 1\u00b718 , 95 % CI 0\u00b785 - 1\u00b764 ; p=0\u00b718 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","bevacizumab"],"drug_indices_start":[53,150],"drug_indices_end":[62,161]}
{"index":1181,"text":"These data suggest that weekly docetaxel plus carboplatin may be an important therapeutic second-line treatment option for patients with DRPC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["docetaxel","carboplatin"],"drug_indices_start":[31,46],"drug_indices_end":[40,57]}
{"index":1182,"text":"' Side-effects ' such as tiredness , decreased inclination to work , and dryness of the mouth were somewhat more frequent after the higher clonidine dose than after both doses of guanfacine , and peaked 2 h after clonidine but only 4 - 6 h after guanfacine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonidine","guanfacine","clonidine","guanfacine"],"drug_indices_start":[139,179,213,246],"drug_indices_end":[148,189,222,256]}
{"index":1183,"text":"The recommended phase II dose is bortezomib 1.0 mg\/m on days 1 , 4 , 8 , and 11 plus docetaxel 75 mg\/m on day 1 , cycled every 21 days .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","docetaxel"],"drug_indices_start":[33,85],"drug_indices_end":[43,94]}
{"index":1185,"text":"In this review , we will discuss the use of anti-EGFR MoAbs in the treatment of mCRC , with focus on cetuximab and panitumumab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","panitumumab"],"drug_indices_start":[101,115],"drug_indices_end":[110,126]}
{"index":1186,"text":"A 29-year-old white man with recurrent Hodgkin 's disease received doxorubicin , bleomycin , vinblastine , and dacarbazine ( ABVD ) chemotherapy once every two weeks for 12 cycles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","bleomycin","vinblastine","dacarbazine"],"drug_indices_start":[67,81,93,111],"drug_indices_end":[78,90,104,122]}
{"index":1188,"text":"Advanced male breast cancer treatment with the LH-RH analogue buserelin alone or in combination with the antiandrogen flutamide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["buserelin","flutamide"],"drug_indices_start":[62,118],"drug_indices_end":[71,127]}
{"index":1189,"text":"A double-blind multicentre trial of piroxicam and naproxen in osteoarthritis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["piroxicam","naproxen"],"drug_indices_start":[36,50],"drug_indices_end":[45,58]}
{"index":1190,"text":"Effects of estradiol , cyproterone acetate , tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fed rabbits .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyproterone acetate","raloxifene"],"drug_indices_start":[23,58],"drug_indices_end":[42,68]}
{"index":1191,"text":"Patients were randomly divided into three groups : group I : band ligation ; group II : propranolol ; group III : carvedilol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","carvedilol"],"drug_indices_start":[88,114],"drug_indices_end":[99,124]}
{"index":1192,"text":"Nevertheless , there are serious doubts as to the specificity of these actions of DA as a number of other substances like naloxone , nicotine , acetylcholine or glutamate-diethylester occasionally had very similar effects on membrane potential , firing rate and cortically evoked EPSP-IPSP sequences .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["naloxone","nicotine","acetylcholine","glutamate-diethylester"],"drug_indices_start":[122,133,144,161],"drug_indices_end":[130,141,157,183]}
{"index":1193,"text":"Here , we validated an indirect competitive enzyme-linked immunosorbent assay ( icELISA ) for quantification of ARTs and found that 50 % of inhibitory concentrations of dihydroartemisinin , artemether , and artesunate were 8.1 , 207.0 , and 4.7 ng\/mL , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dihydroartemisinin","artemether","artesunate"],"drug_indices_start":[169,190,207],"drug_indices_end":[187,200,217]}
{"index":1194,"text":"In an effort to improve its efficacy , mitoxantrone was tested for synergistic activity with cidofovir .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitoxantrone","cidofovir"],"drug_indices_start":[39,93],"drug_indices_end":[51,102]}
{"index":1195,"text":"In our study , the -491A\/T polymorphism in the apo E gene promoter region modulated the lipid-lowering efficiency of atorvastatin and bezafibrate in CHL patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atorvastatin","bezafibrate"],"drug_indices_start":[117,134],"drug_indices_end":[129,145]}
{"index":1196,"text":"A prospective open-label study comparing the efficacy and safety of methotrexate ( MTX ) and chloroquine ( CQ ) in articular and cutaneous manifestations of systemic lupus erythematosus ( SLE ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","chloroquine"],"drug_indices_start":[68,93],"drug_indices_end":[80,104]}
{"index":1197,"text":"In the current study , we investigated the hypothesis that targeting of P-gp by diltiazem can enhance the cytotoxicity of gemcitabine and 5-FU against human pancreatic cancer cells .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["diltiazem","gemcitabine","5-FU"],"drug_indices_start":[80,122,138],"drug_indices_end":[89,133,142]}
{"index":1198,"text":"An additional 2 patients ( 1 in each group ) met the protocol definition of virologic failure between weeks 48 and 96 ; no known resistance mutations were observed in the raltegravir recipient ; the efavirenz recipient had nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor resistance mutations .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["raltegravir","efavirenz"],"drug_indices_start":[171,199],"drug_indices_end":[182,208]}
{"index":1199,"text":"In all , 171 patients with histologically verified non-small cell lung carcinoma were treated with ifosfamide 2.0 g\/m2 on days 1 - 5 in combination with ( 91 patients ) etoposide 120 mg\/m2 on day 1 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","etoposide"],"drug_indices_start":[99,169],"drug_indices_end":[109,178]}
{"index":1201,"text":"In transplant eligible patients , induction therapy consists of bortezomib , lenalidomide , dexamethasone ( VRd ) given for approximately 3 - 4 cycles followed by autologous stem cell transplantation ( ASCT ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","lenalidomide","dexamethasone"],"drug_indices_start":[64,77,92],"drug_indices_end":[74,89,105]}
{"index":1202,"text":"Genistein combined polysaccharide enhances activity of docetaxel , bicalutamide and Src kinase inhibition in androgen-dependent and independent prostate cancer cell lines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Genistein","docetaxel","bicalutamide"],"drug_indices_start":[0,55,67],"drug_indices_end":[9,64,79]}
{"index":1203,"text":"Combination therapy with bosentan and sildenafil was effective for this case of refractory PAH associated with fibrotic lung in systemic sclerosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bosentan","sildenafil"],"drug_indices_start":[25,38],"drug_indices_end":[33,48]}
{"index":1204,"text":"All patients had received concomitant immunosuppressive medications in addition to infliximab or etanercept , and all resided in HC-endemic regions .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["infliximab","etanercept"],"drug_indices_start":[83,97],"drug_indices_end":[93,107]}
{"index":1205,"text":"Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine sulfate , etoposide phosphate , and carboplatin showed no evidence of systemic metastasis in any case during a mean ( range ) follow-up of 66 ( 12 - 202 ) months .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine","etoposide","carboplatin"],"drug_indices_start":[107,129,155],"drug_indices_end":[118,138,166]}
{"index":1206,"text":"Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer : systematic review and economic evaluation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","tegafur"],"drug_indices_start":[35,52],"drug_indices_end":[47,59]}
{"index":1207,"text":"All strains were susceptible to phenoxymethylpenicillin , cephalosporins , erythromycin , azithromycin , clindamycin , vancomycin , doxycycline , and ciprofloxacin but were resistant to trimethoprim-sulfamethoxazole .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erythromycin","azithromycin","clindamycin","vancomycin","doxycycline","ciprofloxacin"],"drug_indices_start":[75,90,105,119,132,150],"drug_indices_end":[87,102,116,129,143,163]}
{"index":1208,"text":"The inhibition by the agonist oxotremorine is comparable to that of carbachol and 1 mM pilocarpine inhibited the binding by 21 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxotremorine","carbachol","pilocarpine"],"drug_indices_start":[30,68,87],"drug_indices_end":[42,77,98]}
{"index":1209,"text":"Cost-effectiveness of cetuximab , cetuximab plus irinotecan , and panitumumab for third and further lines of treatment for KRAS wild-type patients with metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","cetuximab","irinotecan","panitumumab"],"drug_indices_start":[22,34,49,66],"drug_indices_end":[31,43,59,77]}
{"index":1210,"text":"Limits of quantification were 0.12 , 1.09 , 1.46 , 1.47 , 5.70 , 1.32 , 1.33 \u00b5g\/L for haloperidol , aripiprazole , olanzapine , quetiapine , clozapine , risperidone , and paliperidone , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["haloperidol","aripiprazole","olanzapine","quetiapine","clozapine","risperidone","paliperidone"],"drug_indices_start":[86,100,115,128,141,153,171],"drug_indices_end":[97,112,125,138,150,164,183]}
{"index":1211,"text":"Sensitization to doxorubicin and etoposide with BPTF knockdown ( KD ) was associated with increased DNA damage , topoisomerase II ( TOP2 ) crosslinking and autophagy ; however , there was only a modest increase in apoptosis and no increase in senescence .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[17,33],"drug_indices_end":[28,42]}
{"index":1212,"text":"This multicenter pilot study assessed the feasibility and efficacy of a time-intensified bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone ( BEACOPP ) regimen given in 14-day intervals ( BEACOPP-14 ) with granulocyte colony-stimulating factor ( G-CSF ) support in advanced Hodgkin 's lymphoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","etoposide","doxorubicin","cyclophosphamide","vincristine","procarbazine","prednisone"],"drug_indices_start":[89,101,113,127,146,160,179],"drug_indices_end":[98,110,124,143,157,172,189]}
{"index":1213,"text":"Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus-infected patients with renal impairment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["daclatasvir","asunaprevir"],"drug_indices_start":[23,39],"drug_indices_end":[34,50]}
{"index":1214,"text":"We report the results of replacement of steroids by azathioprine ( AZA ) in 25 primary cadaveric renal transplant recipients initially treated with CsA and methylprednisolone ( MP ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azathioprine","CsA","methylprednisolone"],"drug_indices_start":[52,148,156],"drug_indices_end":[64,151,174]}
{"index":1215,"text":"Median OS was 34.2 and 24.3 months in the panitumumab and bevacizumab arms , respectively ( HR , 0.62 ; 95 % CI , 0.44 to 0.89 ; P = .009 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["panitumumab","bevacizumab"],"drug_indices_start":[42,58],"drug_indices_end":[53,69]}
{"index":1216,"text":"One group of patients was treated with oral mefloquine ( 750 mg ) and artemether ( 600 mg by injection , 200 mg initially and 100 mg every 12 h ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","artemether"],"drug_indices_start":[44,70],"drug_indices_end":[54,80]}
{"index":1217,"text":"The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","oxaliplatin"],"drug_indices_start":[12,27],"drug_indices_end":[22,38]}
{"index":1218,"text":"In both cases , chemotherapy comprising rituximab + dose-adjusted EPOCH regimen ( etoposide , prednisone , vincristine , cyclophosphamide and doxorubicin ) was administered .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","etoposide","prednisone","vincristine","cyclophosphamide","doxorubicin"],"drug_indices_start":[40,82,94,107,121,142],"drug_indices_end":[49,91,104,118,137,153]}
{"index":1219,"text":"Bleeding prophylaxis included combinations of plasma-derived factor ( VWD ) or recombinant factor ( haemophilia A and haemophilia B ) , desmopressin and\/or tranexamic acid .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["desmopressin","tranexamic"],"drug_indices_start":[136,156],"drug_indices_end":[148,166]}
{"index":1220,"text":"Although progression-free survival with the bevacizumab plus capecitabine combination is inferior to that noted with bevacizumab plus paclitaxel , we suggest that physicians should consider possible predictive risk factors for overall survival , individual 's treatment priorities , and the differing safety profiles .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bevacizumab","capecitabine","bevacizumab","paclitaxel"],"drug_indices_start":[44,61,117,134],"drug_indices_end":[55,73,128,144]}
{"index":1221,"text":"The combination of ixabepilone and bevacizumab was well tolerated , with modest activity in second - or later-line mRCC , but it is not recommended as a therapy without further clinical development .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ixabepilone","bevacizumab"],"drug_indices_start":[19,35],"drug_indices_end":[30,46]}
{"index":1222,"text":"Eligible patients with unresectable MPM , without disease progression following 4 to 6 cycles of pemetrexed and platinum were randomized 1:1 to observation or continuation of pemetrexed until progression , stratified by number of cycles ( < 6 or 6 ) , cis- or carboplatin containing regimen , and histology .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pemetrexed","platinum","pemetrexed","carboplatin"],"drug_indices_start":[97,112,175,260],"drug_indices_end":[107,120,185,271]}
{"index":1224,"text":"Our results show meaningful activity of T-DM1 after front-line pertuzumab plus trastuzumab and a taxane , with about 27 % of patients having an objective response and 40 % of patients achieving durable disease control .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertuzumab","trastuzumab"],"drug_indices_start":[63,79],"drug_indices_end":[73,90]}
{"index":1225,"text":"Dapagliflozin seemed to play a role in accelerating the patient 's urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dapagliflozin","furosemide"],"drug_indices_start":[0,197],"drug_indices_end":[13,207]}
{"index":1226,"text":"PA combination of goserelin and tamoxifen in patients with relapsed ovarian cancer can not be recommended as standard therapy , but may result in long-term survival in individual patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["goserelin","tamoxifen"],"drug_indices_start":[18,32],"drug_indices_end":[27,41]}
{"index":1227,"text":"In previous analyses of the MURANO study , fixed-duration venetoclax plus rituximab ( VenR ) resulted in improved progression-free survival ( PFS ) compared with bendamustine plus rituximab ( BR ) in patients with relapsed or refractory chronic lymphocytic leukemia ( CLL ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["venetoclax","rituximab","bendamustine","rituximab"],"drug_indices_start":[58,74,162,180],"drug_indices_end":[68,83,174,189]}
{"index":1228,"text":"The aim of the present study was to determine whether a combination of atorvastatin and amlodipine causes sympathoinhibition via reduction of oxidative stress in the RVLM and improves cognitive dysfunction of hypertensive rats .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["atorvastatin","amlodipine"],"drug_indices_start":[71,88],"drug_indices_end":[83,98]}
{"index":1229,"text":"Active treatment consisted of hydrochlorothiazide ( 25 - 50 mg\/day ) plus triamterene ( 50 - 100 mg\/day ) with the addition of alpha-methyldopa ( 0.5 - 2.0 g\/day ) in one-third of the patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["hydrochlorothiazide","triamterene","alpha-methyldopa"],"drug_indices_start":[30,74,127],"drug_indices_end":[49,85,143]}
{"index":1230,"text":"Eight days treatment with 15 \u03bcM clozapine increased adipogenesis by 37.4 % and 50 \u03bcM risperidone increased adipogenesis by 26.5 % during 3T3-L1 cell differentiation accompanied by increased SREBP-1 , PPAR\u03b3 , C\/EBP\u03b1 , LDLR and Adiponectin gene expression .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clozapine","risperidone"],"drug_indices_start":[32,85],"drug_indices_end":[41,96]}
{"index":1231,"text":"It is predicted that patients suffering from both VL and cardiac disorders ( atrial fibrillation ) may benefit if they are treated with warfarin in conjunction with first-line antileishmanial therapies such as miltefosine and AmBisome .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["warfarin","miltefosine"],"drug_indices_start":[136,210],"drug_indices_end":[144,221]}
{"index":1232,"text":"If concomitant therapy is absolutely necessary , the dose of digoxin should be halved prior to initiating dronedarone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["digoxin","dronedarone"],"drug_indices_start":[61,106],"drug_indices_end":[68,117]}
{"index":1233,"text":"Stable isotope labelling by amino acids in cell culture ( SILAC ) coupled to high-resolution mass spectrometry ( MS ) was implemented to globally characterise cellular protein levels induced by KSR1 in the presence of doxorubicin or etoposide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[218,233],"drug_indices_end":[229,242]}
{"index":1234,"text":"All patients received neoadjuvant chemotherapy with cyclophosphamide , doxorubicin , and fluorouracil , or cyclophosphamide , doxorubicin , vincristine , and prednisone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","fluorouracil","cyclophosphamide","doxorubicin","vincristine","prednisone"],"drug_indices_start":[52,71,89,107,126,140,158],"drug_indices_end":[68,82,101,123,137,151,168]}
{"index":1235,"text":"Chemotherapy consisted of ( 1 ) fluorouracil ( 5-FU ) , ( 2 ) 5-FU variations , ( 3 ) 5-FU plus oxaliplatin , ( 4 ) 5-FU plus irinotecan , or ( 5 ) oral fluoropyrimidine-based regimens .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","oxaliplatin","irinotecan"],"drug_indices_start":[32,96,126],"drug_indices_end":[44,107,136]}
{"index":1237,"text":"Comparison of brimonidine with latanoprost in the adjunctive treatment of glaucoma . ALPHAGAN\/XALATAN Study Group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["brimonidine","latanoprost"],"drug_indices_start":[14,31],"drug_indices_end":[25,42]}
{"index":1238,"text":"Pretreatment with inhaled N(2)O can reduce the pain associated with propofol and rocuronium injection .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propofol","rocuronium"],"drug_indices_start":[68,81],"drug_indices_end":[76,91]}
{"index":1239,"text":"To further these observations , we discovered that the bromodomain PHD finger transcription factor subunit ( BPTF ) of the nucleosome remodeling factor ( NURF ) promotes resistance to doxorubicin , etoposide and paclitaxel in the 4T1 breast tumor cell line .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide","paclitaxel"],"drug_indices_start":[184,198,212],"drug_indices_end":[195,207,222]}
{"index":1240,"text":"We analyzed 129 non-Hodgkin lymphoma patients who underwent AHSCT from 1996 to 2013 using the most common regimens : CBV ( cyclophosphamide , carmustine and etoposide ; n = 16 ) , BEAM ( carmustine , etoposide , cytarabine and melphalan ; n = 36 ) and BEAC ( carmustine , etoposide , cytarabine and cyclophosphamide ; n = 77 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","carmustine","etoposide","carmustine","etoposide","cytarabine","melphalan","carmustine","etoposide","cytarabine","cyclophosphamide"],"drug_indices_start":[123,142,157,187,200,212,227,259,272,284,299],"drug_indices_end":[139,152,166,197,209,222,236,269,281,294,315]}
{"index":1241,"text":"Early Prostate-Specific Antigen ( PSA ) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early\/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Abiraterone","Enzalutamide"],"drug_indices_start":[95,111],"drug_indices_end":[106,123]}
{"index":1242,"text":"Several chemotherapy drugs are active in SCCHN , most notably the platinum compounds , taxanes , fluorouracil ( 5-FU ) , methotrexate and cetuximab .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fluorouracil","methotrexate","cetuximab"],"drug_indices_start":[97,121,138],"drug_indices_end":[109,133,147]}
{"index":1243,"text":"Dexamethasone , cytarabine , ifosfamide , and cisplatin as salvage therapy in non-Hodgkin lymphoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dexamethasone","cytarabine","ifosfamide","cisplatin"],"drug_indices_start":[0,16,29,46],"drug_indices_end":[13,26,39,55]}
{"index":1244,"text":"Cost-effectiveness of ribociclib plus letrozole","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ribociclib","letrozole"],"drug_indices_start":[22,38],"drug_indices_end":[32,47]}
{"index":1245,"text":"We investigated whether lapatinib plus gemcitabine has synergistic or antagonistic effects on the pancreatic cancer cell lines MiaPaca-2 and PANC-1 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","gemcitabine"],"drug_indices_start":[24,39],"drug_indices_end":[33,50]}
{"index":1247,"text":"No significant changes of endothelium-independent dilation were observed with both drugs ( from 17.10+\/-2.4 % to 18.14+\/-3.76 % and from 18.73+\/-4.07 % to 17.46+\/-4.27 % during nifedipine and hydrochlorothiazide , respectively , NS ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nifedipine","hydrochlorothiazide"],"drug_indices_start":[177,192],"drug_indices_end":[187,211]}
{"index":1248,"text":"The PANDORA trial has demonstrated that the combination of high dose pantoprazole with docetaxel is tolerable , but the clinical activity was not sufficient to warrant further testing .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pantoprazole","docetaxel"],"drug_indices_start":[69,87],"drug_indices_end":[81,96]}
{"index":1249,"text":"Effective plasma levels of both saquinavir and lopinavir can be achieved by the co-administration of saquinavir soft-gel capsules and lopinavir\/ritonavir .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["saquinavir","lopinavir","saquinavir"],"drug_indices_start":[32,47,101],"drug_indices_end":[42,56,111]}
{"index":1250,"text":"Clopidogrel administration significantly reduces the likelihood of recurrent CATE compared with aspirin in cats ; both drugs were well tolerated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Clopidogrel","aspirin"],"drug_indices_start":[0,96],"drug_indices_end":[11,103]}
{"index":1251,"text":"In recent years several tyrosine kinase inhibitors targeting specific molecular pathways involved in its pathogenesis have been investigated , such as sorafenib , lenvatinib , and sunitinib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sorafenib","lenvatinib","sunitinib"],"drug_indices_start":[151,163,180],"drug_indices_end":[160,173,189]}
{"index":1252,"text":"By passage 25 and thereafter , the selected cells were resistant to doxorubicin , etoposide , mitoxantrone and 5-fluorouracil by a pathway that was independent of MDR1 , MRP1 , MRP2 and breast cancer resistance protein .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide","mitoxantrone"],"drug_indices_start":[68,82,94],"drug_indices_end":[79,91,106]}
{"index":1253,"text":"The in vitro antibacterial activity of zidovudine alone and in combination with ciprofloxacin was investigated .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["zidovudine","ciprofloxacin"],"drug_indices_start":[39,80],"drug_indices_end":[49,93]}
{"index":1254,"text":"This patient was a case of primary antiphospholipid antibody syndrome in which endothelial cell damage was located exclusively in the capillary lumens and pulse cyclophosphamide therapy in addition to prednisolone and anticoagulant was effective .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","prednisolone"],"drug_indices_start":[161,201],"drug_indices_end":[177,213]}
{"index":1255,"text":"Vancomycin and gentamicin were administered systemically just prior to surgery and streptomycin was added to the irrigating solution .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vancomycin","gentamicin","streptomycin"],"drug_indices_start":[0,15,83],"drug_indices_end":[10,25,95]}
{"index":1256,"text":"We observed a synergistic cytotoxic effect for the combination of foretinib and lapatinib on the viability and proliferation of the examined melanoma cell lines .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["foretinib","lapatinib"],"drug_indices_start":[66,80],"drug_indices_end":[75,89]}
{"index":1257,"text":"Regarding microbiological cure metronidazole therapy was as effective as vancomycin therapy ( RR=0.88 , 95 % CI=0.64 - 1.21 , p=0.43 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metronidazole","vancomycin"],"drug_indices_start":[31,73],"drug_indices_end":[44,83]}
{"index":1258,"text":"During the infusion protocol used in clinical practice , etoposide , cytarabine and daunorubicine were stable and compatible with the various materials present in the infusion sets and extension tubing ( polyvinyl chloride , polyethylene ) and catheters ( silicone ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","cytarabine"],"drug_indices_start":[57,69],"drug_indices_end":[66,79]}
{"index":1259,"text":"Following knockdown of ANXA2 in NB cell line SK-N-BE(2 ) using shRNA , we demonstrate enhanced drug sensitivity for doxorubicin ( 2.77-fold ) and etoposide ( 7.87-fold ) compared with control .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","etoposide"],"drug_indices_start":[116,146],"drug_indices_end":[127,155]}
{"index":1260,"text":"Combined therapy with amiodarone and carvedilol provided greatest reduction of sudden arrhythmic and total mortality .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amiodarone","carvedilol"],"drug_indices_start":[22,37],"drug_indices_end":[32,47]}
{"index":1261,"text":"Efficacy of paclitaxel , carboplatin , and bevacizumab for cervical cancer : A protocol for systematic review and meta-analysis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","bevacizumab"],"drug_indices_start":[12,25,43],"drug_indices_end":[22,36,54]}
{"index":1262,"text":"The eradication rate of C. trachomatis in baseline-positive patients at the first follow-up visit in the azithromycin group was 96 % with one persistent case , and 100 % in the doxycycline group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["azithromycin","doxycycline"],"drug_indices_start":[105,177],"drug_indices_end":[117,188]}
{"index":1263,"text":"For example , the overall objective response rate of 9.5 % with single agent sunitinib compares similarly to that of pemetrexed or docetaxel in previously treated NSCLC patients , but toxicity , notably fatigue , lead to discontinuation in 38 % of patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sunitinib","pemetrexed","docetaxel"],"drug_indices_start":[77,117,131],"drug_indices_end":[86,127,140]}
{"index":1264,"text":"Patients with progressive refractory NSCLC who had previously benefitted from erlotinib ( objective response or stable disease > 8weeks ) were randomized to receive treatment with either erlotinib and sorafenib ( 400 mg orally twice daily ) or sorafenib alone .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","erlotinib","sorafenib","sorafenib"],"drug_indices_start":[78,187,201,244],"drug_indices_end":[87,196,210,253]}
{"index":1265,"text":"In this challenging field , aflibercept offers a good option for oxaliplatin-refractory mCRC patients when combined with irinotecan and 5-fluorouracil irrespective of prior anti-angiogenic treatment .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aflibercept","irinotecan","5-fluorouracil"],"drug_indices_start":[28,121,136],"drug_indices_end":[39,131,150]}
{"index":1266,"text":"The combination of 1-hour paclitaxel , carboplatin , and extended oral schedule etoposide is feasible and well tolerated at the doses administered in this phase II trial .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","etoposide"],"drug_indices_start":[26,39,80],"drug_indices_end":[36,50,89]}
{"index":1267,"text":"In this regard , we have synthesized Pem-PEG-Gem , wherein pemetrexed ( Pem ) and gemcitabine ( Gem ) are conjugated to a heterobifunctional polyethylene glycol ( PEG ) polymer for the effective treatment of Non-Small Cell Lung Cancer ( NSCLC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pemetrexed","gemcitabine"],"drug_indices_start":[59,82],"drug_indices_end":[69,93]}
{"index":1268,"text":"After the initiation of antimalarial treatment with artesunate and mefloquine , his clinical condition gradually improved .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["artesunate","mefloquine"],"drug_indices_start":[52,67],"drug_indices_end":[62,77]}
{"index":1269,"text":"For those few patients who do not respond to first-line therapy , the combination of vinblastine , ifosfamide , and cisplatin is the most popular regimen for the subset of platinum-sensitive tumors .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vinblastine","ifosfamide","cisplatin"],"drug_indices_start":[85,99,116],"drug_indices_end":[96,109,125]}
{"index":1270,"text":"Antibiotic treatment was changed to imipenem\/cilastatin , piperacillin , gentamicin , clarithromycin , erythromycin , and minocycline .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["piperacillin","gentamicin","clarithromycin","erythromycin","minocycline"],"drug_indices_start":[58,73,86,103,122],"drug_indices_end":[70,83,100,115,133]}
{"index":1271,"text":"Patients received once-daily vandetanib ( planned dosing levels of 100 , 200 , and 300 mg ) with concomitant daily radiotherapy ( 1.8 Gy\/d , 45 Gy total ) and chemotherapy , consisting of infusional 5-FU ( 225 mg\/m\/d over 96 h , weekly ) , paclitaxel ( 50 mg\/m , days 1 , 8 , 15 , 22 , 29 ) and carboplatin ( AUC of 5 , days 1 , 29 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vandetanib","5-FU","paclitaxel","carboplatin"],"drug_indices_start":[29,199,240,295],"drug_indices_end":[39,203,250,306]}
{"index":1272,"text":"Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tamoxifen","toremifene"],"drug_indices_start":[25,61],"drug_indices_end":[34,71]}
{"index":1273,"text":"Eighteen patients received chemotherapy including etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( n = 13 ) and cyclophosphamide , doxorubicin , vincristine , and prednisone ( n = 2 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","prednisone","vincristine","cyclophosphamide","doxorubicin","and cyclophospha","e , doxorub","n , vincris","and predni"],"drug_indices_start":[50,62,75,89,112,139,158,172,190],"drug_indices_end":[59,72,86,105,123,155,169,183,200]}
{"index":1274,"text":"The calcium channel blocker verapamil has been previously shown to augment the chemosensitivity of pancreatic adenocarcinoma cell lines to doxorubicin by mechanisms other than changes in the intracellular accumulation , retention , or metabolism of doxorubicin .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["verapamil","doxorubicin","doxorubicin"],"drug_indices_start":[28,139,249],"drug_indices_end":[37,150,260]}
{"index":1275,"text":"The results of a randomized phase II trial have demonstrated that the addition of cetuximab to irinotecan in patients with irinotecan-resistant tumors represents another active treatment option for these patients .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","irinotecan"],"drug_indices_start":[82,95],"drug_indices_end":[91,105]}
{"index":1276,"text":"Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["digoxin","flecainide"],"drug_indices_start":[66,78],"drug_indices_end":[73,88]}
{"index":1277,"text":"A phase I\/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["irinotecan","capecitabine"],"drug_indices_start":[42,73],"drug_indices_end":[52,85]}
{"index":1278,"text":"The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vancomycin","TZP","vancomycin","cefepime"],"drug_indices_start":[76,91,210,225],"drug_indices_end":[86,94,220,233]}
{"index":1279,"text":"In patients who experience disease progression after etoposide , doxorubicin , cisplatin with mitotane ( EDP-M ) , gemcitabine and metronomic capecitabine , or the less used streptozotocin , represent a second-line chemotherapy option .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etoposide","doxorubicin","cisplatin","mitotane","gemcitabine","capecitabine","streptozotocin"],"drug_indices_start":[53,65,79,94,115,142,174],"drug_indices_end":[62,76,88,102,126,154,188]}
{"index":1280,"text":"We conclude that ropivacaine alone injected into the pterygomandibular region does not affect the cardiovascular system and that the addition of epinephrine has no beneficial effect .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ropivacaine","epinephrine"],"drug_indices_start":[17,145],"drug_indices_end":[28,156]}
{"index":1281,"text":"The next broad-spectrum drug was ethionamide , followed by ansamycin , rifampin , capreomycin , kanamycin , streptomycin and ethambutol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ethionamide","rifampin","capreomycin","kanamycin","streptomycin","ethambutol","ansamycin"],"drug_indices_start":[33,59,71,82,96,108,125],"drug_indices_end":[44,68,79,93,105,120,135]}
{"index":1282,"text":"Phase I\/II study of gefitinib and capecitabine in patients with colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gefitinib","capecitabine"],"drug_indices_start":[20,34],"drug_indices_end":[29,46]}
{"index":1283,"text":"Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ibrutinib","venetoclax"],"drug_indices_start":[23,56],"drug_indices_end":[32,66]}
{"index":1284,"text":"The chloroethylating nitrosoureas ( lomustine , fotemustine , cystemustine ( BCNU ) and methylating agents temozolomide ( TMZ ) , dacarbazine ( DTIC ) , procarbazine ) have documented activity in metastatic malignant melanoma with single agent response rates of 15 - 25 % .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lomustine","temozolomide","dacarbazine","procarbazine"],"drug_indices_start":[36,107,130,153],"drug_indices_end":[45,119,141,165]}
{"index":1285,"text":"The population growth rate was adversely influenced by exposure to chlortetracycline , sulfamethazine , or sulfathiazole in water fleas , but reduction in population size was not expected .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chlortetracycline","sulfamethazine","sulfathiazole"],"drug_indices_start":[67,87,107],"drug_indices_end":[84,101,120]}
{"index":1286,"text":"A group of 14 patients with small-cell lung cancer received a 1-h intravenous infusion of 2.0 or 3.0 g\/m2 ifosfamide over 1 or 2 days in combination with 175 mg\/m2 paclitaxel and carboplatin at AUC 6 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","paclitaxel","carboplatin"],"drug_indices_start":[106,164,179],"drug_indices_end":[116,174,190]}
{"index":1287,"text":"Ticlopidine and clopidogrel achieve antiplatelet effects by inhibiting the binding of adenosine 5'-disphosphate to its platelet receptor .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ticlopidine","clopidogrel"],"drug_indices_start":[0,16],"drug_indices_end":[11,27]}
{"index":1288,"text":"Irinotecan plus gemcitabine induces both radiographic and CA 19 - 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Irinotecan","gemcitabine"],"drug_indices_start":[0,16],"drug_indices_end":[10,27]}
{"index":1289,"text":"The patient was treated with a combination of cyclophosphamide , doxorubicin , vincristine , and prednisone as initial management immediately after diagnosis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","doxorubicin","vincristine","prednisone"],"drug_indices_start":[46,65,79,97],"drug_indices_end":[62,76,90,107]}
{"index":1290,"text":"To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["linezolid","methadone"],"drug_indices_start":[76,90],"drug_indices_end":[85,99]}
{"index":1292,"text":"Anesthetized rats received a single intravenous injection of epinephrine ( 25 , 50 , or 100 mcg\/kg ) ; matched cohorts were pretreated with phentolamine ( 100 mcg\/kg ) ; n = 5 for each of the six treatment groups .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["epinephrine","phentolamine"],"drug_indices_start":[61,140],"drug_indices_end":[72,152]}
{"index":1293,"text":"Three interventions exhibited significantly improved OS results over chemotherapy ( all HR < 1 ): Ipilimumab , Nivolumab and Ipilimumab + Chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ipilimumab","Nivolumab","Ipilimumab","Chemotherapy"],"drug_indices_start":[98,111,125,138],"drug_indices_end":[108,120,135,150]}
{"index":1294,"text":"The breast trial participants studied were those elderly enrolled between 1995 and 1997 and treated with doxorubicin and cyclophosphamide or this combination with paclitaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","cyclophosphamide","paclitaxel"],"drug_indices_start":[105,121,163],"drug_indices_end":[116,137,173]}
{"index":1295,"text":"The intensive polychemotherapy regimen eBEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone in escalated doses ) is very active in patients with advanced-stage Hodgkin 's lymphoma , albeit at the expense of severe toxicities .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bleomycin","etoposide","doxorubicin","cyclophosphamide","vincristine","procarbazine","prednisone"],"drug_indices_start":[50,62,74,88,107,121,140],"drug_indices_end":[59,71,85,104,118,133,150]}
{"index":1296,"text":"Systemic treatments , and here in particular a combined therapeutic regimen of chemotherapy and electron beam , bexarotene , or denileukin diftitox , showed more adverse effects than topical or skin-directed treatments .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bexarotene","denileukin diftitox"],"drug_indices_start":[112,128],"drug_indices_end":[122,147]}
{"index":1297,"text":"The incident number of the infected mice was significantly different among groups with different drugs and doses : 2\/60 , 16\/60 , 10\/60 and 10\/60 in the groups of Changqing capsule , spiramycin , pyrimethamine and azithromycin respectively ( P < 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["spiramycin","pyrimethamine","azithromycin"],"drug_indices_start":[183,196,214],"drug_indices_end":[193,209,226]}
{"index":1298,"text":"In total , seven different interventions ( Chloroquine , Mefloquine , Mefloquine artesunate , Proguanil , Pyrimethamine , Sulfadoxine-pyrimethamine , Sulfadoxine-pyrimethamine amodiaquine ) were evaluated in 912 children with SCD .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Chloroquine","Mefloquine","Mefloquine","artesunate","Proguanil","Pyrimethamine","amodiaquine"],"drug_indices_start":[43,57,70,81,94,106,176],"drug_indices_end":[54,67,80,91,103,119,187]}
{"index":1299,"text":"We have modeled drug resistance by generating three MM cell lines with acquired resistance to either bortezomib , carfilzomib , or ixazomib .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","carfilzomib","ixazomib"],"drug_indices_start":[101,114,131],"drug_indices_end":[111,125,139]}
{"index":1300,"text":"However , we observed significant decreases in the left ventricular mass index and urinary albumin to creatinine ratio in the valsartan group but not in the amlodipine group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["valsartan","amlodipine"],"drug_indices_start":[126,157],"drug_indices_end":[135,167]}
{"index":1301,"text":"Effects of chloroquine , mefloquine and quinine on natural killer cell activity in vitro .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["chloroquine","mefloquine","quinine"],"drug_indices_start":[11,25,40],"drug_indices_end":[22,35,47]}
{"index":1303,"text":"Risk factors associated with cardiotoxicity within 2 years of doxorubicin administration included age [ adjusted hazard ratio ( aHR ) = 1.02 , 95 % confidence interval ( CI ) 1.00 - 1.04 ; p = 0.05 ] , metastasis ( aHR = 2.66 ; 95 % CI 1.36 - 5.20 ; p < 0.01 ) , and concomitant trastuzumab ( aHR = 4.08 ; 95 % CI 2.31 - 7.21 ; p","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","trastuzumab"],"drug_indices_start":[62,279],"drug_indices_end":[73,290]}
{"index":1304,"text":"Twenty-four patients have been treated to date , and the maximum tolerated dose has been reached at paclitaxel 185 mg\/m2 and carboplatin 350 mg\/m2 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[100,125],"drug_indices_end":[110,136]}
{"index":1305,"text":"FAB M5 was significantly more sensitive than FAB M4 to most drugs frequently used in AML , as indicated by the following ratios of median sensitivities : the anthracyclines ( 2.6- to 3.2-fold ) , mitoxantrone ( 12.5-fold ) , etoposide ( 8.7-fold ) , and cytarabine ( 2.9-fold ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mitoxantrone","etoposide","cytarabine"],"drug_indices_start":[196,225,254],"drug_indices_end":[208,234,264]}
{"index":1306,"text":"[ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aztreonam","gentamicin","piperacillin"],"drug_indices_start":[2,15,40],"drug_indices_end":[11,25,52]}
{"index":1307,"text":"The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["salbutamol","digoxin"],"drug_indices_start":[68,106],"drug_indices_end":[78,113]}
{"index":1308,"text":"Mecamylamine reversed the effects of nicotine on SHR performance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Mecamylamine","nicotine"],"drug_indices_start":[0,37],"drug_indices_end":[12,45]}
{"index":1309,"text":"The combination of sub-effective doses of leflunomide and cyclosporin A resulted in significant inhibition of chronic arthritis .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["leflunomide","cyclosporin"],"drug_indices_start":[42,58],"drug_indices_end":[53,69]}
{"index":1310,"text":"In the metastatic setting , FOLFIRINOX ( folinic acid , 5-fluorouracil , irinotecan , and oxaliplatin ) , and nab-paclitaxel plus gemcitabine have yielded only modest improvements in survival .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["folinic","5-fluorouracil","irinotecan","oxaliplatin","nab-paclitaxel","gemcitabine"],"drug_indices_start":[41,56,73,90,110,130],"drug_indices_end":[48,70,83,101,124,141]}
{"index":1311,"text":"Patients in arm 1 ( n = 88 ) received 4 cycles of paclitaxel and carboplatin followed by 2 to 4 cycles of gemcitabine-based combination chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","carboplatin","gemcitabine-based"],"drug_indices_start":[50,65,106],"drug_indices_end":[60,76,123]}
{"index":1312,"text":"In patients receiving digoxin and propafenone simultaneously , the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["digoxin","propafenone","digoxin"],"drug_indices_start":[22,34,100],"drug_indices_end":[29,45,107]}
{"index":1313,"text":"To review the clinical effectiveness and cost-effectiveness evidence base for lapatinib ( LAP ) in combination with an aromatase inhibitor ( AI ) and trastuzumab ( TRA ) in combination with an AI for the first-line treatment of patients who have hormone receptor-positive (HR+)\/human epidermal growth factor 2-positive ( HER2 + ) mBC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","AI","trastuzumab"],"drug_indices_start":[78,141,150],"drug_indices_end":[87,143,161]}
{"index":1314,"text":"Since combination therapy with nateglinide and vildagliptin restored the decrease in pancreatic beta cell mass , our present findings suggest that combination therapy could be a promising therapeutic strategy for postprandial dysmetabolism associated with obese and insulin resistance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nateglinide","vildagliptin"],"drug_indices_start":[31,47],"drug_indices_end":[42,59]}
{"index":1315,"text":"Paclitaxel , doxorubicin , tamoxifen , erlotinib , gefitinib , temozolomide , and methotrexate are among therapeutic agents whose efficacy is influenced by the expression of H19 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","doxorubicin","tamoxifen","erlotinib","gefitinib","temozolomide","methotrexate"],"drug_indices_start":[0,13,27,39,51,63,82],"drug_indices_end":[10,24,36,48,60,75,94]}
{"index":1316,"text":"Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclophosphamide","vincristine","etoposide","methotrexate","doxorubicin"],"drug_indices_start":[96,115,131,233,250],"drug_indices_end":[112,126,140,245,261]}
{"index":1317,"text":"Amisulpride demonstrated a greater improvement in BPRS total scores ( P<0.05 ) and PANSS negative subscores ( P=0.0001 ) than haloperidol after 12 months of treatment in chronic schizophrenic patients with acute exacerbations .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Amisulpride","haloperidol"],"drug_indices_start":[0,126],"drug_indices_end":[11,137]}
{"index":1318,"text":"In patients with acute cholecystitis , ampicillin plus tobramycin , cefoperazone and piperacillin had clinical cure rates of 85 , 95 and 95 per cent , respectively .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ampicillin","tobramycin","cefoperazone","piperacillin"],"drug_indices_start":[39,55,68,85],"drug_indices_end":[49,65,80,97]}
{"index":1319,"text":"A retrospective analysis of the Phase III trial of pemetrexed versus docetaxel shows a statistically significant longer toxicity-free survival time for pemetrexed compared with docetaxel .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pemetrexed","docetaxel","pemetrexed","docetaxel"],"drug_indices_start":[51,69,152,177],"drug_indices_end":[61,78,162,186]}
{"index":1320,"text":"Tazobactam has inhibitory activity , and therefore protects piperacillin against Richmond and Sykes types II , III , IV and V beta-lactamases , staphylococcal penicillinase and extended-spectrum beta-lactamases .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Tazobactam","piperacillin"],"drug_indices_start":[0,60],"drug_indices_end":[10,72]}
{"index":1321,"text":"The diagnosis was stage IIIA HHV-8-LBL , and he was treated with 6 cycles of R-EPOCH ( rituximab , etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) infusion chemotherapy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["rituximab","etoposide","vincristine","doxorubicin","cyclophosphamide","prednisone"],"drug_indices_start":[87,99,111,125,139,162],"drug_indices_end":[96,108,122,136,155,172]}
{"index":1322,"text":"Our objective was to define the maximum tolerated dose of an escalating dose of ifosfamide in combination with a fixed dose of doxorubicin supported by granulocyte colony-stimulating factor ( Neupogen ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ifosfamide","doxorubicin"],"drug_indices_start":[80,127],"drug_indices_end":[90,138]}
{"index":1323,"text":"A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily Filgrastim in patients with stage II-IV breast cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pegfilgrastim","Filgrastim"],"drug_indices_start":[73,120],"drug_indices_end":[86,130]}
{"index":1324,"text":"[ Nilotinib in patients with chronic myeloid leukemia without response to imatinib ] .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Nilotinib","imatinib"],"drug_indices_start":[2,74],"drug_indices_end":[11,82]}
{"index":1325,"text":"At initial treatment with dabrafenib plus trametinib , three patients achieved a partial response and one patient achieved a complete response .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dabrafenib","trametinib"],"drug_indices_start":[26,42],"drug_indices_end":[36,52]}
{"index":1326,"text":"We performed this meta-analysis to evaluate the clinical efficacy and safety of gemcitabine plus cisplatin ( GP ) and paclitaxel plus cisplatin ( TP ) combined with thermotherapy in the treatment of NSCLC , as well as to provide reference for clinical practice and future research .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gemcitabine","cisplatin","paclitaxel","cisplatin","thermotherapy"],"drug_indices_start":[80,97,118,134,165],"drug_indices_end":[91,106,128,143,178]}
{"index":1327,"text":"The pharmacodynamic effects of ticagrelor were preserved when ticagrelor was given during infusion of cangrelor .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ticagrelor","ticagrelor","cangrelor"],"drug_indices_start":[31,62,102],"drug_indices_end":[41,72,111]}
{"index":1328,"text":"A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin , paclitaxel , and bevacizumab with partial response .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carboplatin","paclitaxel","bevacizumab"],"drug_indices_start":[212,226,243],"drug_indices_end":[223,236,254]}
{"index":1329,"text":"Sipuleucel-T , cabazitaxel , abiraterone , enzalutamide and radium-223 have been approved in the pre- or post-docetaxel setting in metastatic CRPC during the last few years .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sipuleucel-T","cabazitaxel","abiraterone","enzalutamide","radium-223"],"drug_indices_start":[0,15,29,43,60],"drug_indices_end":[12,26,40,55,70]}
{"index":1330,"text":"Therefore , we conducted this phase II study to evaluate the activity and toxicity of the combination paclitaxel and gemcitabine in advanced NSCLC .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["paclitaxel","gemcitabine"],"drug_indices_start":[102,117],"drug_indices_end":[112,128]}
{"index":1331,"text":"Two of these antibodies , cetuximab ( Erbitux ) und bevacizumab ( Avastin ) , directed against the epidermal growth factor receptor ( EGFR ) and the vascular epithelial growth factor ( VEGF ) , respectively , have recently been approved for use in metastatic colorectal cancer .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cetuximab","bevacizumab"],"drug_indices_start":[26,52],"drug_indices_end":[35,63]}
{"index":1332,"text":"Physically cross-linked beta-lactoglobulin ( BLG ) protein gels containing theophylline and sulfamethoxazole low molecular weight drugs were prepared in 50 % ethanol solution at pH 8 and two protein concentrations ( 6 and 7 % ( w\/v ) ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["theophylline","sulfamethoxazole"],"drug_indices_start":[75,92],"drug_indices_end":[87,108]}
{"index":1333,"text":"Ciprofloxacin , 500 mg orally twice a day plus antifungal prophylaxis , fluconazole 50 mg once daily plus amphotericin B tablets or suspension and tablets , each 200 mg four times a day , was given .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ciprofloxacin","fluconazole","amphotericin"],"drug_indices_start":[0,72,106],"drug_indices_end":[13,83,118]}
{"index":1334,"text":"In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["panitumumab","irinotecan"],"drug_indices_start":[87,115],"drug_indices_end":[98,125]}
{"index":1335,"text":"A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vemurafenib","cobimetinib","VEMUPLINT"],"drug_indices_start":[31,48,82],"drug_indices_end":[42,59,91]}
{"index":1336,"text":"Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tremelimumab","sunitinib"],"drug_indices_start":[33,51],"drug_indices_end":[45,60]}
{"index":1338,"text":"On the basis of the estimated costs of infective complications , cefotaxime and ceftriaxone appear equally effective for the prevention of infective complications after abdominal surgery .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cefotaxime","ceftriaxone"],"drug_indices_start":[65,80],"drug_indices_end":[75,91]}
{"index":1339,"text":"The epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR TKIs ) like erlotinib and gefitinib have been extensively studied .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erlotinib","gefitinib"],"drug_indices_start":[83,97],"drug_indices_end":[92,106]}
{"index":1341,"text":"This study was conducted to test the feasibility of reducing the interval between cycles of doxorubicin , cyclophosphamide , etoposide ( ACE ) chemotherapy to 2 weeks , thereby increasing dose intensity , by adding granulocyte colony-stimulating factor ( G-CSF ) to reduce the duration of neutropenia following a cycle .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","cyclophosphamide","etoposide","G-CSF"],"drug_indices_start":[92,106,125,255],"drug_indices_end":[103,122,134,260]}
{"index":1342,"text":"The rate of down-stage to pT1 or less was 59 % for methotrexate , vinblastine , doxorubicin and cisplatin , and 53 % for gemcitabine and carboplatin ( P = 0.624 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methotrexate","vinblastine","doxorubicin","cisplatin","gemcitabine","carboplatin"],"drug_indices_start":[51,66,80,96,121,137],"drug_indices_end":[63,77,91,105,132,148]}
{"index":1343,"text":"The combined irrigation of bupivacaine and ketorolac showed a clinically significant reduction of pain in the first postoperative hour and on postoperative day 5 .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bupivacaine","ketorolac"],"drug_indices_start":[27,43],"drug_indices_end":[38,52]}
{"index":1344,"text":"In group I , clinical response was observed in 10 of 19 febrile episodes ( 52.6 % ) treated with carbenicillin plus gentamicin and in 10 of 14 ( 71.4 % ) treated with latamoxef ( p greater than 0.05 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbenicillin","gentamicin","latamoxef"],"drug_indices_start":[97,116,167],"drug_indices_end":[110,126,176]}
{"index":1345,"text":"Following lapatinib and trastuzumab , the HER2-E and ERBB2 (HER2-E\/ERBB2)-high group showed a higher pCR rate compared to the rest ( 44.5 % , 95 % confidence interval [ CI ] = 35.4 % to 53.9 % vs 11.6 % , 95 % CI = 6.9 % to 18.0 % ; adjusted odds ratio [ OR ] = 6.05 , 95 % CI = 3.10 to 11.80 , P < .001 ) .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lapatinib","trastuzumab"],"drug_indices_start":[10,24],"drug_indices_end":[19,35]}
{"index":1346,"text":"A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Troglitazone","Lovastatin"],"drug_indices_start":[36,53],"drug_indices_end":[48,63]}
{"index":1347,"text":"Fingolimod sensitizes EGFR wild\u2011type non\u2011small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Fingolimod","lapatinib","sorafenib"],"drug_indices_start":[0,73,86],"drug_indices_end":[10,82,95]}
{"index":1348,"text":"To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone ( GnRH ) agonist triptorelin or the GnRH antagonist cetrorelix .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["triptorelin","cetrorelix"],"drug_indices_start":[126,161],"drug_indices_end":[137,171]}
{"index":1349,"text":"In vitro effects of racemates , separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mefloquine","halofantrine","metoprolol"],"drug_indices_start":[78,93,109],"drug_indices_end":[88,105,119]}
{"index":1350,"text":"Other studies are evaluating the use of capecitabine , oxaliplatin , and the anti-epidermal growth factor receptor agent cetuximab with RT in this malignancy .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine","oxaliplatin","cetuximab"],"drug_indices_start":[40,55,121],"drug_indices_end":[52,66,130]}
{"index":1351,"text":"Bacteriological , histopathologic , and clinical outcomes after treatment using moxifloxacin , moxifloxacin and dexamethasone combination , and vancomycin were comparable .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["moxifloxacin","moxifloxacin","dexamethasone","vancomycin"],"drug_indices_start":[80,95,112,144],"drug_indices_end":[92,107,125,154]}
{"index":1352,"text":"Combining erythromycin , clarithromycin , or azithromycin with rifampin resulted in a significant ( P\u22640.005 ) decrease in MPC and MPC\/MIC ratio .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["erythromycin","clarithromycin","azithromycin","rifampin"],"drug_indices_start":[10,25,45,63],"drug_indices_end":[22,39,57,71]}
{"index":1353,"text":"This was confirmed and show that the dCK levels are retained upon co-treatment , indicating a clinical use for bortezomib treatment in combination with cytarabine to avoid development of resistance .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["bortezomib","cytarabine"],"drug_indices_start":[111,152],"drug_indices_end":[121,162]}
{"index":1354,"text":"Artemether , artesunate , praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis : a comparative in vivo study .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Artemether","artesunate","praziquantel"],"drug_indices_start":[0,13,26],"drug_indices_end":[10,23,38]}
{"index":1355,"text":"The agents studied include : propranolol , timolol , metoprolol , practolol , atenolol and the combined alpha and beta adrenoceptor blocking agent , labetalol .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propranolol","timolol","metoprolol","atenolol","labetalol"],"drug_indices_start":[29,43,53,78,149],"drug_indices_end":[40,50,63,86,158]}
{"index":1356,"text":"Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fenofibrate","lovastatin"],"drug_indices_start":[11,48],"drug_indices_end":[22,58]}
{"index":1357,"text":"Idasanutlin was tolerable alone and in combination with cytarabine .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Idasanutlin","cytarabine"],"drug_indices_start":[0,56],"drug_indices_end":[11,66]}
{"index":1358,"text":"Cell surface proteins induced by fludarabine and cladribine may be targets for therapeutic antibodies .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["fludarabine","cladribine"],"drug_indices_start":[33,49],"drug_indices_end":[44,59]}
{"index":1359,"text":"After seven days of chemotherapy with 5-fluorouracil , oxaliplatin and bevacizumab , exploratory surgery revealed a perforation at the ileum .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["5-fluorouracil","oxaliplatin","bevacizumab"],"drug_indices_start":[38,55,71],"drug_indices_end":[52,66,82]}
{"index":1360,"text":"Nausea graded none or mild 24 h after the start of cisplatin infusion was reported in 71 and 69 % of patients in the 8- and 32-mg ondansetron groups , respectively , and in 73 % of patients in the granisetron group .","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cisplatin","ondansetron","granisetron"],"drug_indices_start":[51,130,197],"drug_indices_end":[60,141,208]}
{"index":0,"text":"Naloxone reverses the antihypertensive effect of clonidine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Naloxone","clonidine"],"drug_indices_start":[0,49],"drug_indices_end":[8,58]}
{"index":2,"text":"Lidocaine-induced cardiac asystole.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac asystole"],"disease_indices_start":[18],"disease_indices_end":[34],"drugs":["Lidocaine"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":4,"text":"Suxamethonium infusion rate and observed fasciculations. A dose-response study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["fasciculations"],"disease_indices_start":[41],"disease_indices_end":[55],"drugs":["Suxamethonium"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":6,"text":"Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Galanthamine hydrobromide","scopolamine","Hyoscine"],"drug_indices_start":[0,124,111],"drug_indices_end":[25,122,132]}
{"index":8,"text":"Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chronic renal failure"],"disease_indices_start":[70],"disease_indices_end":[91],"drugs":["lithium"],"drug_indices_start":[54],"drug_indices_end":[61]}
{"index":10,"text":"Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Crohn's disease"],"disease_indices_start":[13],"disease_indices_end":[28],"drugs":["fusidic acid","cyclosporin"],"drug_indices_start":[34,107],"drug_indices_end":[118,46]}
{"index":12,"text":"Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial injury"],"disease_indices_start":[33],"disease_indices_end":[50],"drugs":["cocaine"],"drug_indices_start":[83],"drug_indices_end":[90]}
{"index":13,"text":"The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["schizophrenic","myocardial injury","myocardial infarction","ischemia","bundle branch block"],"disease_indices_start":[194,305,334,357,371],"disease_indices_end":[207,322,355,365,390],"drugs":["cocaine","cocaine"],"drug_indices_start":[232,135],"drug_indices_end":[142,239]}
{"index":14,"text":"Sulpiride-induced tardive dystonia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tardive dystonia"],"disease_indices_start":[18],"disease_indices_end":[34],"drugs":["Sulpiride"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":16,"text":"Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Ocular and auditory toxicity","Ocular","auditory toxicity"],"disease_indices_start":[0,11],"disease_indices_end":[6,28],"drugs":["desferrioxamine"],"drug_indices_start":[64],"drug_indices_end":[79]}
{"index":18,"text":"Myasthenia gravis presenting as weakness after magnesium administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Myasthenia gravis"],"disease_indices_start":[0],"disease_indices_end":[17],"drugs":["magnesium"],"drug_indices_start":[47],"drug_indices_end":[56]}
{"index":20,"text":"Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study\/short communication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Chloroacetaldehyde","cyclophosphamide","ifosfamide"],"drug_indices_start":[0,97,77],"drug_indices_end":[18,107,93]}
{"index":22,"text":"Source of pain and primitive dysfunction in migraine: an identical site?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain","migraine"],"disease_indices_start":[10,44],"disease_indices_end":[14,52],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":24,"text":"Clotiazepam-induced acute hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis"],"disease_indices_start":[26],"disease_indices_end":[35],"drugs":["Clotiazepam"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":26,"text":"Arterial hypertension as a complication of prolonged ketoconazole treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[9],"disease_indices_end":[21],"drugs":["ketoconazole"],"drug_indices_start":[53],"drug_indices_end":[65]}
{"index":28,"text":"Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pulmonary and renal insufficiency","pulmonary","renal insufficiency","intravascular coagulation"],"disease_indices_start":[72,86,113],"disease_indices_end":[81,105,138],"drugs":["angiotensin","Captopril"],"drug_indices_start":[58,27],"drug_indices_end":[67,38]}
{"index":30,"text":"A randomized comparison of labetalol and nitroprusside for induced hypotension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[67],"disease_indices_end":[78],"drugs":["labetalol","nitroprusside"],"drug_indices_start":[41,27],"drug_indices_end":[36,54]}
{"index":32,"text":"Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[54],"disease_indices_end":[62],"drugs":["carbamazepine","folate"],"drug_indices_start":[8,96],"drug_indices_end":[21,102]}
{"index":36,"text":"Death from chemotherapy in gestational trophoblastic disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Death","gestational trophoblastic disease"],"disease_indices_start":[0,27],"disease_indices_end":[5,60],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":38,"text":"Sexual dysfunction among patients with arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Sexual dysfunction","arthritis"],"disease_indices_start":[0,39],"disease_indices_end":[18,48],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":40,"text":"Does paracetamol cause urothelial cancer or renal papillary necrosis?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["urothelial cancer","renal papillary necrosis"],"disease_indices_start":[23,44],"disease_indices_end":[40,68],"drugs":["paracetamol"],"drug_indices_start":[5],"drug_indices_end":[16]}
{"index":42,"text":"Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolytic anemia"],"disease_indices_start":[30],"disease_indices_end":[46],"drugs":["Dapsone"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":44,"text":"Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["metoprolol","propafenone","diltiazem","sparteine"],"drug_indices_start":[98,123,110,138],"drug_indices_end":[121,147,108,132]}
{"index":46,"text":"Triazolam-induced brief episodes of secondary mania in a depressed patient.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mania","depressed"],"disease_indices_start":[46,57],"disease_indices_end":[51,66],"drugs":["Triazolam"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":47,"text":"Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mania","depressed","organic mental disorder","delirium","Manic"],"disease_indices_start":[138,149,186,211,239],"disease_indices_end":[143,158,209,219,244],"drugs":["triazolam","triazolam","triazolo"],"drug_indices_start":[346,91,302],"drug_indices_end":[354,100,311]}
{"index":48,"text":"On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscular rigidity"],"disease_indices_start":[57],"disease_indices_end":[74],"drugs":["morphine"],"drug_indices_start":[87],"drug_indices_end":[95]}
{"index":50,"text":"Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Compression neuropathy of the radial nerve","Compression neuropathy","neuropathy of the radial nerve","fibrous myopathy"],"disease_indices_start":[0,12,70],"disease_indices_end":[22,42,86],"drugs":["pentazocine"],"drug_indices_start":[50],"drug_indices_end":[61]}
{"index":52,"text":"Recurrent reversible acute renal failure from amphotericin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute renal failure"],"disease_indices_start":[21],"disease_indices_end":[40],"drugs":["amphotericin"],"drug_indices_start":[46],"drug_indices_end":[58]}
{"index":54,"text":"Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pleural and pericardial effusion","pleural","pericardial effusion","neuropathy"],"disease_indices_start":[17,29,54],"disease_indices_end":[24,49,64],"drugs":["amiodarone"],"drug_indices_start":[72],"drug_indices_end":[82]}
{"index":56,"text":"Indomethacin-induced renal insufficiency: recurrence on rechallenge.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal insufficiency"],"disease_indices_start":[21],"disease_indices_end":[40],"drugs":["Indomethacin"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":58,"text":"Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["flunitrazepam"],"drug_indices_start":[105],"drug_indices_end":[118]}
{"index":60,"text":"Changes in heart size during long-term timolol treatment after myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[63],"disease_indices_end":[84],"drugs":["timolol"],"drug_indices_start":[39],"drug_indices_end":[46]}
{"index":62,"text":"Vitamin D3 toxicity in dairy cows.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[11],"disease_indices_end":[19],"drugs":["Vitamin D3"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":64,"text":"Diseases of peripheral nerves as seen in the Nigerian African.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Diseases of peripheral nerves"],"disease_indices_start":[0],"disease_indices_end":[29],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":66,"text":"A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["depressive disorder"],"disease_indices_start":[101],"disease_indices_end":[120],"drugs":["dothiepin hydrochloride"],"drug_indices_start":[51],"drug_indices_end":[74]}
{"index":68,"text":"Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["panic disorder","agoraphobia"],"disease_indices_start":[64,83],"disease_indices_end":[78,94],"drugs":["diazepam","propranolol"],"drug_indices_start":[35,22],"drug_indices_end":[46,30]}
{"index":70,"text":"Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide"],"drug_indices_start":[10,21],"drug_indices_end":[17,66]}
{"index":72,"text":"Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","diabetic autonomic neuropathy"],"disease_indices_start":[24,56],"disease_indices_end":[35,85],"drugs":["nitroglycerin"],"drug_indices_start":[39],"drug_indices_end":[52]}
{"index":74,"text":"Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["adenohypophyseal tumors"],"disease_indices_start":[37],"disease_indices_end":[60],"drugs":["estrogen"],"drug_indices_start":[20],"drug_indices_end":[28]}
{"index":76,"text":"Triamterene nephrolithiasis complicating dyazide therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrolithiasis"],"disease_indices_start":[12],"disease_indices_end":[27],"drugs":["Triamterene","dyazide"],"drug_indices_start":[0,41],"drug_indices_end":[48,11]}
{"index":78,"text":"Metabolic involvement in adriamycin cardiotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[36],"disease_indices_end":[50],"drugs":["adriamycin"],"drug_indices_start":[25],"drug_indices_end":[35]}
{"index":80,"text":"Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxic"],"disease_indices_start":[40],"disease_indices_end":[50],"drugs":["streptomycin"],"drug_indices_start":[62],"drug_indices_end":[74]}
{"index":82,"text":"Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glomerulonephritis","pulmonary tuberculosis"],"disease_indices_start":[22,91],"disease_indices_end":[40,113],"drugs":["rifampin"],"drug_indices_start":[70],"drug_indices_end":[78]}
{"index":84,"text":"Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[71],"disease_indices_end":[82],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[37],"drug_indices_end":[62]}
{"index":86,"text":"Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sleep disturbance"],"disease_indices_start":[21],"disease_indices_end":[38],"drugs":["Clomipramine"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":88,"text":"Angioedema following the intravenous administration of metoprolol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Angioedema"],"disease_indices_start":[0],"disease_indices_end":[10],"drugs":["metoprolol"],"drug_indices_start":[55],"drug_indices_end":[65]}
{"index":90,"text":"Effect of coniine on the developing chick embryo.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["coniine"],"drug_indices_start":[10],"drug_indices_end":[17]}
{"index":92,"text":"Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[68],"disease_indices_end":[79],"drugs":["prostaglandin E1","trimethaphan"],"drug_indices_start":[27,47],"drug_indices_end":[59,43]}
{"index":94,"text":"Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["axonal damage"],"disease_indices_start":[73],"disease_indices_end":[86],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":96,"text":"Increase of Parkinson disability after fluoxetine medication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson disability"],"disease_indices_start":[12],"disease_indices_end":[32],"drugs":["fluoxetine"],"drug_indices_start":[39],"drug_indices_end":[49]}
{"index":98,"text":"Acetaminophen-induced hypotension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[22],"disease_indices_end":[33],"drugs":["Acetaminophen"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":100,"text":"Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis","autoimmune hemolytic anemia","erythroblastocytopenia"],"disease_indices_start":[6,17,50],"disease_indices_end":[15,44,72],"drugs":["ceftriaxone"],"drug_indices_start":[84],"drug_indices_end":[95]}
{"index":104,"text":"Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombosis","platelet aggregation"],"disease_indices_start":[57,86],"disease_indices_end":[67,106],"drugs":["tetrandrine","fangchinoline"],"drug_indices_start":[27,11],"drug_indices_end":[40,22]}
{"index":106,"text":"Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive cisplatin. Oncopaz Cooperative Group.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nonsmall cell lung carcinoma"],"disease_indices_start":[32],"disease_indices_end":[60],"drugs":["Gemcitabine","vinorelbine","cisplatin"],"drug_indices_start":[0,17,123],"drug_indices_end":[132,11,28]}
{"index":108,"text":"Warfarin-induced artery calcification is accelerated by growth and vitamin D.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["artery calcification"],"disease_indices_start":[17],"disease_indices_end":[37],"drugs":["Warfarin","vitamin D"],"drug_indices_start":[0,67],"drug_indices_end":[8,76]}
{"index":110,"text":"Antidepressant-induced mania in bipolar patients: identification of risk factors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mania","bipolar"],"disease_indices_start":[23,32],"disease_indices_end":[28,39],"drugs":["Antidepressant"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":112,"text":"Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac arrhythmia"],"disease_indices_start":[17],"disease_indices_end":[35],"drugs":["Caffeine"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":113,"text":"We describe a 25-year-old woman with pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consuming a \"natural energy\" guarana health drink containing a high concentration of caffeine. This case highlights the need for adequate labelling and regulation of such products.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mitral valve prolapse","ventricular fibrillation"],"disease_indices_start":[134,182],"disease_indices_end":[155,206],"drugs":["caffeine"],"drug_indices_start":[298],"drug_indices_end":[306]}
{"index":114,"text":"Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retention of urine"],"disease_indices_start":[8],"disease_indices_end":[26],"drugs":["fentanyl"],"drug_indices_start":[77],"drug_indices_end":[85]}
{"index":116,"text":"Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiomyopathy","AIDS"],"disease_indices_start":[39,96],"disease_indices_end":[53,100],"drugs":["lactate"],"drug_indices_start":[74],"drug_indices_end":[81]}
{"index":118,"text":"Oral contraceptives and the risk of myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[36],"disease_indices_end":[57],"drugs":["Oral contraceptives"],"drug_indices_start":[0],"drug_indices_end":[19]}
{"index":120,"text":"Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["locomotor hyperactivity"],"disease_indices_start":[104],"disease_indices_end":[127],"drugs":["cocaine"],"drug_indices_start":[88],"drug_indices_end":[95]}
{"index":122,"text":"Ticlopidine-induced cholestatic hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cholestatic hepatitis","cholestatic","hepatitis"],"disease_indices_start":[20,32],"disease_indices_end":[31,41],"drugs":["Ticlopidine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":124,"text":"Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotic syndrome"],"disease_indices_start":[116],"disease_indices_end":[134],"drugs":["sodium","puromycin aminonucleoside"],"drug_indices_start":[82,11],"drug_indices_end":[17,107]}
{"index":126,"text":"NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["migraine"],"disease_indices_start":[11],"disease_indices_end":[19],"drugs":["NO","calcitonin gene-related peptide","CGRP","serotonin"],"drug_indices_start":[0,146,54,87],"drug_indices_end":[2,91,155,85]}
{"index":128,"text":"Coronary aneurysm after implantation of a paclitaxel-eluting stent.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Coronary aneurysm"],"disease_indices_start":[0],"disease_indices_end":[17],"drugs":["paclitaxel"],"drug_indices_start":[42],"drug_indices_end":[52]}
{"index":130,"text":"Behavioral effects of urotensin-II centrally administered in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["urotensin-II"],"drug_indices_start":[22],"drug_indices_end":[34]}
{"index":132,"text":"Recurrent dysphonia and acitretin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dysphonia"],"disease_indices_start":[10],"disease_indices_end":[19],"drugs":["acitretin"],"drug_indices_start":[24],"drug_indices_end":[33]}
{"index":134,"text":"Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[30],"disease_indices_end":[34],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":136,"text":"MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["impaired social and emotional judgement processes"],"disease_indices_start":[85],"disease_indices_end":[134],"drugs":["MDMA"],"drug_indices_start":[0],"drug_indices_end":[4]}
{"index":138,"text":"Severe citrate toxicity complicating volunteer apheresis platelet donation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[15],"disease_indices_end":[23],"drugs":["citrate"],"drug_indices_start":[7],"drug_indices_end":[14]}
{"index":140,"text":"Proteinuria after conversion to sirolimus in renal transplant recipients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Proteinuria"],"disease_indices_start":[0],"disease_indices_end":[11],"drugs":["sirolimus"],"drug_indices_start":[32],"drug_indices_end":[41]}
{"index":142,"text":"In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cystitis"],"disease_indices_start":[99],"disease_indices_end":[107],"drugs":["cyclophosphamide"],"drug_indices_start":[74],"drug_indices_end":[90]}
{"index":144,"text":"Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["benzodiazepines"],"drug_indices_start":[28],"drug_indices_end":[43]}
{"index":146,"text":"Acute vocal fold palsy after acute disulfiram intoxication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vocal fold palsy"],"disease_indices_start":[6],"disease_indices_end":[22],"drugs":["disulfiram"],"drug_indices_start":[35],"drug_indices_end":[45]}
{"index":148,"text":"Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombosis","thrombocytopenia"],"disease_indices_start":[52,96],"disease_indices_end":[62,112],"drugs":["heparin"],"drug_indices_start":[80],"drug_indices_end":[87]}
{"index":150,"text":"Central retinal vein occlusion associated with clomiphene-induced ovulation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retinal vein occlusion"],"disease_indices_start":[8],"disease_indices_end":[30],"drugs":["clomiphene"],"drug_indices_start":[47],"drug_indices_end":[57]}
{"index":152,"text":"Nicotine-induced nystagmus correlates with midpontine activation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nystagmus"],"disease_indices_start":[17],"disease_indices_end":[26],"drugs":["Nicotine"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":154,"text":"Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gastric hemorrhagic","ulcers","atherosclerotic"],"disease_indices_start":[34,54,71],"disease_indices_end":[53,60,86],"drugs":["verapamil"],"drug_indices_start":[21],"drug_indices_end":[30]}
{"index":156,"text":"Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["death","heart failure"],"disease_indices_start":[44,92],"disease_indices_end":[49,105],"drugs":["Adriamycin"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":158,"text":"Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Confusion"],"disease_indices_start":[0],"disease_indices_end":[9],"drugs":["valproic acid"],"drug_indices_start":[55],"drug_indices_end":[68]}
{"index":160,"text":"Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Learning and memory deficits","Learning","memory deficits"],"disease_indices_start":[0,13],"disease_indices_end":[8,28],"drugs":["ecstasy"],"drug_indices_start":[32],"drug_indices_end":[39]}
{"index":162,"text":"Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia","thrombosis"],"disease_indices_start":[117,139],"disease_indices_end":[133,149],"drugs":["argatroban","heparin"],"drug_indices_start":[101,30],"drug_indices_end":[40,108]}
{"index":164,"text":"Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute liver failure"],"disease_indices_start":[33],"disease_indices_end":[52],"drugs":["Antituberculosis"],"drug_indices_start":[0],"drug_indices_end":[16]}
{"index":166,"text":"Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Central nervous system complications","acute lymphoblastic leukemia"],"disease_indices_start":[0,57],"disease_indices_end":[36,85],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":168,"text":"Safety of capecitabine: a review.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["capecitabine"],"drug_indices_start":[10],"drug_indices_end":[22]}
{"index":170,"text":"Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["parkinsonian catalepsy"],"disease_indices_start":[55],"disease_indices_end":[77],"drugs":["neurotensin","haloperidol"],"drug_indices_start":[35,20],"drug_indices_end":[46,31]}
{"index":172,"text":"Antihypertensive drugs and depression: a reappraisal.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["depression"],"disease_indices_start":[27],"disease_indices_end":[37],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":174,"text":"Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside-induced hypotension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[82],"disease_indices_end":[93],"drugs":["nitroprusside"],"drug_indices_start":[60],"drug_indices_end":[73]}
{"index":176,"text":"Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia"],"disease_indices_start":[35],"disease_indices_end":[46],"drugs":["L-dopa","dopamine"],"drug_indices_start":[50,69],"drug_indices_end":[56,77]}
{"index":178,"text":"Cocaine-induced myocardial infarction: clinical observations and pathogenetic considerations.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[16],"disease_indices_end":[37],"drugs":["Cocaine"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":180,"text":"Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Rabbit syndrome"],"disease_indices_start":[0],"disease_indices_end":[15],"drugs":["antidepressant"],"drug_indices_start":[17],"drug_indices_end":[31]}
{"index":182,"text":"Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chronic obstructive pulmonary disease"],"disease_indices_start":[73],"disease_indices_end":[110],"drugs":["ipratropium bromide","theophylline"],"drug_indices_start":[33,57],"drug_indices_end":[52,69]}
{"index":184,"text":"Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[76],"disease_indices_end":[87],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":186,"text":"Less frequent lithium administration and lower urine volume.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lithium"],"drug_indices_start":[14],"drug_indices_end":[21]}
{"index":188,"text":"Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperthermia","tumor"],"disease_indices_start":[46,62],"disease_indices_end":[58,67],"drugs":["adriamycin"],"drug_indices_start":[10],"drug_indices_end":[20]}
{"index":190,"text":"Prazosin-induced stress incontinence.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["stress incontinence"],"disease_indices_start":[17],"disease_indices_end":[36],"drugs":["Prazosin"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":192,"text":"Myocardial infarction following sublingual administration of isosorbide dinitrate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Myocardial infarction"],"disease_indices_start":[0],"disease_indices_end":[21],"drugs":["isosorbide dinitrate"],"drug_indices_start":[61],"drug_indices_end":[81]}
{"index":194,"text":"Fluoxetine-induced akathisia: clinical and theoretical implications.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["akathisia"],"disease_indices_start":[19],"disease_indices_end":[28],"drugs":["Fluoxetine"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":196,"text":"Chronic active hepatitis associated with diclofenac sodium therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Chronic active hepatitis"],"disease_indices_start":[0],"disease_indices_end":[24],"drugs":["diclofenac sodium"],"drug_indices_start":[41],"drug_indices_end":[58]}
{"index":198,"text":"Stroke associated with cocaine use.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Stroke"],"disease_indices_start":[0],"disease_indices_end":[6],"drugs":["cocaine"],"drug_indices_start":[23],"drug_indices_end":[30]}
{"index":200,"text":"Glyburide-induced hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis"],"disease_indices_start":[18],"disease_indices_end":[27],"drugs":["Glyburide"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":202,"text":"Systolic pressure variation is greater during hemorrhage than during sodium nitroprusside-induced hypotension in ventilated dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhage","hypotension"],"disease_indices_start":[46,98],"disease_indices_end":[56,109],"drugs":["sodium nitroprusside"],"drug_indices_start":[69],"drug_indices_end":[89]}
{"index":204,"text":"Drug-induced arterial spasm relieved by lidocaine. Case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["spasm"],"disease_indices_start":[22],"disease_indices_end":[27],"drugs":["lidocaine"],"drug_indices_start":[40],"drug_indices_end":[49]}
{"index":206,"text":"Cerebral blood flow and metabolism during isoflurane-induced hypotension in patients subjected to surgery for cerebral aneurysms.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","cerebral aneurysms"],"disease_indices_start":[61,110],"disease_indices_end":[72,128],"drugs":["isoflurane"],"drug_indices_start":[42],"drug_indices_end":[52]}
{"index":208,"text":"Allergic reaction to 5-fluorouracil infusion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Allergic reaction"],"disease_indices_start":[0],"disease_indices_end":[17],"drugs":["5-fluorouracil"],"drug_indices_start":[21],"drug_indices_end":[35]}
{"index":210,"text":"Amiodarone-induced sinoatrial block.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sinoatrial block"],"disease_indices_start":[19],"disease_indices_end":[35],"drugs":["Amiodarone"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":211,"text":"We observed sinoatrial block due to chronic amiodarone administration in a 5-year-old boy with primary cardiomyopathy, Wolff-Parkinson-White syndrome and supraventricular tachycardia. Reduction in the dosage of amiodarone resulted in the disappearance of the sinoatrial block and the persistence of asymptomatic sinus bradycardia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sinoatrial block","primary cardiomyopathy","Wolff-Parkinson-White syndrome","supraventricular tachycardia","sinoatrial block","sinus bradycardia"],"disease_indices_start":[49,132,156,191,296,349],"disease_indices_end":[65,154,186,219,312,366],"drugs":["amiodarone","amiodarone"],"drug_indices_start":[248,81],"drug_indices_end":[258,91]}
{"index":212,"text":"Possible teratogenicity of sulphasalazine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sulphasalazine"],"drug_indices_start":[27],"drug_indices_end":[41]}
{"index":214,"text":"Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Veno-occlusive liver disease","melanoma"],"disease_indices_start":[0,66],"disease_indices_end":[28,74],"drugs":["dacarbazine","DTIC"],"drug_indices_start":[56,35],"drug_indices_end":[60,46]}
{"index":216,"text":"A case of tardive dyskinesia caused by metoclopramide.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tardive dyskinesia"],"disease_indices_start":[10],"disease_indices_end":[28],"drugs":["metoclopramide"],"drug_indices_start":[39],"drug_indices_end":[53]}
{"index":218,"text":"Further observations on the electrophysiologic effects of oral amiodarone therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amiodarone"],"drug_indices_start":[63],"drug_indices_end":[73]}
{"index":220,"text":"Busulfan-induced hemorrhagic cystitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhagic cystitis","hemorrhagic","cystitis"],"disease_indices_start":[17,29],"disease_indices_end":[28,37],"drugs":["Busulfan"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":222,"text":"Rebound hypertensive after sodium nitroprusside prevented by saralasin in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[8],"disease_indices_end":[20],"drugs":["sodium nitroprusside","saralasin"],"drug_indices_start":[27,61],"drug_indices_end":[70,47]}
{"index":224,"text":"Toxic hepatitis induced by antithyroid drugs: four cases including one with cross-reactivity between carbimazole and benzylthiouracil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Toxic hepatitis"],"disease_indices_start":[0],"disease_indices_end":[15],"drugs":["carbimazole","benzylthiouracil"],"drug_indices_start":[117,101],"drug_indices_end":[112,133]}
{"index":226,"text":"Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[92],"disease_indices_end":[100],"drugs":["vitamin B12","folinic acid","zidovudine"],"drug_indices_start":[104,37,21],"drug_indices_end":[32,49,114]}
{"index":228,"text":"Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["confusion"],"disease_indices_start":[6],"disease_indices_end":[15],"drugs":["5-fluorouracil","folinic acid"],"drug_indices_start":[51,70],"drug_indices_end":[65,82]}
{"index":230,"text":"Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbamazepine","oxcarbazepine"],"drug_indices_start":[20,37],"drug_indices_end":[33,50]}
{"index":232,"text":"Erythema multiforme and hypersensitivity myocarditis caused by ampicillin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Erythema multiforme","hypersensitivity myocarditis"],"disease_indices_start":[0,24],"disease_indices_end":[19,52],"drugs":["ampicillin"],"drug_indices_start":[63],"drug_indices_end":[73]}
{"index":234,"text":"Immediate allergic reactions to amoxicillin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["allergic reactions"],"disease_indices_start":[10],"disease_indices_end":[28],"drugs":["amoxicillin"],"drug_indices_start":[32],"drug_indices_end":[43]}
{"index":236,"text":"Persistent paralysis after prolonged use of atracurium in the absence of corticosteroids.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["paralysis"],"disease_indices_start":[11],"disease_indices_end":[20],"drugs":["atracurium"],"drug_indices_start":[44],"drug_indices_end":[54]}
{"index":238,"text":"Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chronic renal failure"],"disease_indices_start":[51],"disease_indices_end":[72],"drugs":["acetaminophen","phenacetin"],"drug_indices_start":[16,92],"drug_indices_end":[29,102]}
{"index":240,"text":"Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetic nephropathy"],"disease_indices_start":[127],"disease_indices_end":[147],"drugs":["heparan sulphate","streptozotocin"],"drug_indices_start":[104,13],"drug_indices_end":[29,118]}
{"index":242,"text":"Effect of some anticancer drugs and combined chemotherapy on renal toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal toxicity"],"disease_indices_start":[61],"disease_indices_end":[75],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":244,"text":"Lithium-associated cognitive and functional deficits reduced by a switch to divalproex sodium: a case series.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive and functional deficits"],"disease_indices_start":[19],"disease_indices_end":[52],"drugs":["Lithium","divalproex sodium"],"drug_indices_start":[0,76],"drug_indices_end":[93,7]}
{"index":246,"text":"Treatment of previously treated metastatic breast cancer by mitoxantrone and 48-hour continuous infusion of high-dose 5-FU and leucovorin (MFL): low palliative benefit and high treatment-related toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast cancer","toxicity"],"disease_indices_start":[43,195],"disease_indices_end":[56,203],"drugs":["mitoxantrone","5-FU","leucovorin","MFL"],"drug_indices_start":[139,60,118,127],"drug_indices_end":[72,137,122,142]}
{"index":248,"text":"Upregulation of the expression of vasopressin gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetes insipidus"],"disease_indices_start":[119],"disease_indices_end":[137],"drugs":["vasopressin","lithium"],"drug_indices_start":[34,103],"drug_indices_end":[45,110]}
{"index":250,"text":"Suxamethonium-induced cardiac arrest and death following 5 days of immobilization.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac arrest","death"],"disease_indices_start":[22,41],"disease_indices_end":[36,46],"drugs":["Suxamethonium"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":252,"text":"An unusual toxic reaction to axillary block by mepivacaine with adrenaline.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["mepivacaine","adrenaline"],"drug_indices_start":[64,47],"drug_indices_end":[58,74]}
{"index":254,"text":"Clinical and histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tacrolimus","FK506"],"drug_indices_start":[74,86],"drug_indices_end":[91,84]}
{"index":256,"text":"Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG-9.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["acetylcholine","PG-9"],"drug_indices_start":[110,87],"drug_indices_end":[114,100]}
{"index":258,"text":"Angioedema due to ACE inhibitors: common and inadequately diagnosed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Angioedema"],"disease_indices_start":[0],"disease_indices_end":[10],"drugs":["ACE inhibitors"],"drug_indices_start":[18],"drug_indices_end":[32]}
{"index":259,"text":"The estimated incidence of angioedema during angiotensin-converting enzyme (ACE) inhibitor treatment is between 1 and 7 per thousand patients. This potentially serious adverse effect is often preceded by minor manifestations that may serve as a warning.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["angioedema"],"disease_indices_start":[96],"disease_indices_end":[106],"drugs":["angiotensin-converting enzyme (ACE) inhibitor"],"drug_indices_start":[114],"drug_indices_end":[159]}
{"index":262,"text":"Recurrent use of newer oral contraceptives and the risk of venous thromboembolism.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["venous thromboembolism"],"disease_indices_start":[59],"disease_indices_end":[81],"drugs":["oral contraceptives"],"drug_indices_start":[23],"drug_indices_end":[42]}
{"index":264,"text":"Development of apomorphine-induced aggressive behavior: comparison of adult male and female Wistar rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aggressive behavior"],"disease_indices_start":[35],"disease_indices_end":[54],"drugs":["apomorphine"],"drug_indices_start":[15],"drug_indices_end":[26]}
{"index":266,"text":"Serotonergic antidepressants and urinary incontinence.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["urinary incontinence"],"disease_indices_start":[33],"disease_indices_end":[53],"drugs":["Serotonergic antidepressants"],"drug_indices_start":[0],"drug_indices_end":[28]}
{"index":268,"text":"Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypotension","hypertension"],"disease_indices_start":[0,132],"disease_indices_end":[11,144],"drugs":["tizanidine","angiotensin"],"drug_indices_start":[40,80],"drug_indices_end":[50,91]}
{"index":270,"text":"Peritubular capillary basement membrane reduplication in allografts and native kidney disease: a clinicopathologic study of 278 consecutive renal specimens.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["kidney disease"],"disease_indices_start":[79],"disease_indices_end":[93],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
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{"index":418,"text":"Prospective study of the long-term effects of somatostatin analog (octreotide) on gallbladder function and gallstone formation in Chinese acromegalic patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gallstone","acromegalic"],"disease_indices_start":[107,138],"disease_indices_end":[116,149],"drugs":["octreotide"],"drug_indices_start":[67],"drug_indices_end":[77]}
{"index":420,"text":"Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesia","Parkinson's disease"],"disease_indices_start":[32,61],"disease_indices_end":[42,80],"drugs":["levodopa","propranolol"],"drug_indices_start":[46,15],"drug_indices_end":[57,23]}
{"index":422,"text":"Morphological features of encephalopathy after chronic administration of the antiepileptic drug valproate to rats. A transmission electron microscopic study of capillaries in the cerebellar cortex.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalopathy"],"disease_indices_start":[26],"disease_indices_end":[40],"drugs":["valproate"],"drug_indices_start":[96],"drug_indices_end":[105]}
{"index":424,"text":"Macula toxicity after intravitreal amikacin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[7],"disease_indices_end":[15],"drugs":["amikacin"],"drug_indices_start":[35],"drug_indices_end":[43]}
{"index":426,"text":"Iatrogenically induced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff-Parkinson-White syndrome and idiopathic dilated cardiomyopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrioventricular reentrant tachycardia","Wolff-Parkinson-White syndrome","idiopathic dilated cardiomyopathy"],"disease_indices_start":[35,130,165],"disease_indices_end":[73,160,198],"drugs":["verapamil"],"drug_indices_start":[80],"drug_indices_end":[89]}
{"index":427,"text":"In a patient with WPW syndrome and idiopathic dilated cardiomyopathy, intractable atrioventricular reentrant tachycardia (AVRT) was iatrogenically induced. QRS without preexcitation, caused by junctional escape beats after verapamil or unidirectional antegrade block of accessory pathway after catheter ablation, established frequent AVRT attack.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["WPW syndrome","idiopathic dilated cardiomyopathy","atrioventricular reentrant tachycardia","AVRT","AVRT"],"disease_indices_start":[218,235,282,322,534],"disease_indices_end":[230,268,320,326,538],"drugs":["verapamil"],"drug_indices_start":[423],"drug_indices_end":[432]}
{"index":428,"text":"Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["liver disease"],"disease_indices_start":[12],"disease_indices_end":[25],"drugs":["hydrochlorofluorocarbons","ozone","chlorofluorocarbons"],"drug_indices_start":[98,36,69],"drug_indices_end":[74,60,117]}
{"index":430,"text":"The effect of different anaesthetic agents in hearing loss following spinal anaesthesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hearing loss"],"disease_indices_start":[46],"disease_indices_end":[58],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":432,"text":"A transient neurological deficit following intrathecal injection of 1% hyperbaric bupivacaine for unilateral spinal anaesthesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurological deficit"],"disease_indices_start":[12],"disease_indices_end":[32],"drugs":["bupivacaine"],"drug_indices_start":[82],"drug_indices_end":[93]}
{"index":434,"text":"Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure","postoperative pain"],"disease_indices_start":[21,77],"disease_indices_end":[28,95],"drugs":["Pethidine","pethidine"],"drug_indices_start":[0,63],"drug_indices_end":[72,9]}
{"index":436,"text":"Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vanishing bile duct","Stevens-Johnson syndromes"],"disease_indices_start":[28,52],"disease_indices_end":[47,77],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":438,"text":"High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["primary pulmonary hypertension"],"disease_indices_start":[18],"disease_indices_end":[48],"drugs":["appetite suppressants"],"drug_indices_start":[65],"drug_indices_end":[86]}
{"index":440,"text":"Choreoathetoid movements associated with rapid adjustment to methadone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Choreoathetoid movements"],"disease_indices_start":[0],"disease_indices_end":[24],"drugs":["methadone"],"drug_indices_start":[61],"drug_indices_end":[70]}
{"index":442,"text":"Cocaine-induced mood disorder: prevalence rates and psychiatric symptoms in an outpatient cocaine-dependent sample.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mood disorder","psychiatric"],"disease_indices_start":[16,52],"disease_indices_end":[29,63],"drugs":["Cocaine","cocaine"],"drug_indices_start":[0,90],"drug_indices_end":[97,7]}
{"index":444,"text":"Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hemolysis"],"disease_indices_start":[0],"disease_indices_end":[9],"drugs":["tamoxifen"],"drug_indices_start":[43],"drug_indices_end":[52]}
{"index":446,"text":"Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[106],"disease_indices_end":[118],"drugs":["sodium","ATP","Na","K","nitric oxide"],"drug_indices_start":[11,83,53,22,56],"drug_indices_end":[17,55,57,25,95]}
{"index":448,"text":"Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tachycardia"],"disease_indices_start":[78],"disease_indices_end":[89],"drugs":["isoproterenol","bromocriptine"],"drug_indices_start":[56,39],"drug_indices_end":[52,69]}
{"index":450,"text":"A developmental analysis of clonidine's effects on cardiac rate and ultrasound production in infant rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonidine"],"drug_indices_start":[28],"drug_indices_end":[37]}
{"index":452,"text":"Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperalgesia"],"disease_indices_start":[95],"disease_indices_end":[107],"drugs":["ketamine","lidocaine","capsaicin"],"drug_indices_start":[50,131,63],"drug_indices_end":[72,58,140]}
{"index":454,"text":"Cyclosporine and tacrolimus-associated thrombotic microangiopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombotic microangiopathy"],"disease_indices_start":[39],"disease_indices_end":[65],"drugs":["Cyclosporine","tacrolimus"],"drug_indices_start":[0,17],"drug_indices_end":[27,12]}
{"index":456,"text":"Repeated transient anuria following losartan administration in a patient with a solitary kidney.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anuria"],"disease_indices_start":[19],"disease_indices_end":[25],"drugs":["losartan"],"drug_indices_start":[36],"drug_indices_end":[44]}
{"index":458,"text":"In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["necrotic","nephrotoxicity","lung toxicity","cardiotoxicity"],"disease_indices_start":[58,108,143,181],"disease_indices_end":[66,122,156,195],"drugs":["acetaminophen","amiodarone","doxorubicin","IH636 grape seed proanthocyanidin extract"],"drug_indices_start":[161,124,86,207],"drug_indices_end":[248,99,172,134]}
{"index":460,"text":"Palpebral twitching in a depressed adolescent on citalopram.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Palpebral twitching","depressed"],"disease_indices_start":[0,25],"disease_indices_end":[19,34],"drugs":["citalopram"],"drug_indices_start":[49],"drug_indices_end":[59]}
{"index":462,"text":"Metamizol potentiates morphine antinociception but not constipation after chronic treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["constipation"],"disease_indices_start":[55],"disease_indices_end":[67],"drugs":["Metamizol","morphine"],"drug_indices_start":[0,22],"drug_indices_end":[9,30]}
{"index":464,"text":"Ifosfamide encephalopathy presenting with asterixis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalopathy","asterixis"],"disease_indices_start":[11,42],"disease_indices_end":[25,51],"drugs":["Ifosfamide"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":466,"text":"Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gamma-vinyl GABA","vigabatrin","cocaine","dopamine"],"drug_indices_start":[107,60,21,39],"drug_indices_end":[115,49,67,37]}
{"index":468,"text":"Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemorrhage rat model.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bleeding","hematoma","intracerebral hemorrhage"],"disease_indices_start":[10,23,64],"disease_indices_end":[18,31,88],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":470,"text":"Estradiol reduces seizure-induced hippocampal injury in ovariectomized female but not in male rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure","hippocampal injury"],"disease_indices_start":[18,34],"disease_indices_end":[25,52],"drugs":["Estradiol"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":472,"text":"Delirium during clozapine treatment: incidence and associated risk factors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Delirium"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["clozapine"],"drug_indices_start":[16],"drug_indices_end":[25]}
{"index":474,"text":"Ketoconazole-induced neurologic sequelae.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurologic sequelae"],"disease_indices_start":[21],"disease_indices_end":[40],"drugs":["Ketoconazole"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":476,"text":"Noxious chemical stimulation of rat facial mucosa increases intracranial blood flow through a trigemino-parasympathetic reflex--an experimental model for vascular dysfunctions in cluster headache.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vascular dysfunctions","cluster headache"],"disease_indices_start":[154,179],"disease_indices_end":[175,195],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":478,"text":"Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["temporal lobe epilepsy"],"disease_indices_start":[63],"disease_indices_end":[85],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":480,"text":"The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures","hypolocomotion"],"disease_indices_start":[98,111],"disease_indices_end":[106,125],"drugs":["acetylcholine","nicotine"],"drug_indices_start":[81,31],"drug_indices_end":[89,44]}
{"index":482,"text":"Recurrent acute interstitial nephritis induced by azithromycin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["interstitial nephritis"],"disease_indices_start":[16],"disease_indices_end":[38],"drugs":["azithromycin"],"drug_indices_start":[50],"drug_indices_end":[62]}
{"index":484,"text":"Valproate-induced encephalopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalopathy"],"disease_indices_start":[18],"disease_indices_end":[32],"drugs":["Valproate"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":486,"text":"Nitro-L-arginine methyl ester: a potential protector against gentamicin ototoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ototoxicity"],"disease_indices_start":[72],"disease_indices_end":[83],"drugs":["Nitro-L-arginine methyl ester","gentamicin"],"drug_indices_start":[0,61],"drug_indices_end":[29,71]}
{"index":488,"text":"Cerebral vasculitis following oral methylphenidate intake in an adult: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cerebral vasculitis"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["methylphenidate"],"drug_indices_start":[35],"drug_indices_end":[50]}
{"index":490,"text":"Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cerebral haemorrhage"],"disease_indices_start":[0],"disease_indices_end":[20],"drugs":["warfarin"],"drug_indices_start":[32],"drug_indices_end":[40]}
{"index":492,"text":"Side effects of postoperative administration of methylprednisolone and gentamicin into the posterior sub-Tenon's space.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methylprednisolone","gentamicin"],"drug_indices_start":[48,71],"drug_indices_end":[81,66]}
{"index":494,"text":"Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy","chronic kidney disease"],"disease_indices_start":[115,144],"disease_indices_end":[126,166],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":496,"text":"A novel compound, maltolyl p-coumarate, attenuates cognitive deficits and shows neuroprotective effects in vitro and in vivo dementia models.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive deficits","dementia"],"disease_indices_start":[51,125],"disease_indices_end":[69,133],"drugs":["maltolyl p-coumarate"],"drug_indices_start":[18],"drug_indices_end":[38]}
{"index":498,"text":"Interaction between warfarin and levofloxacin: case series.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["warfarin","levofloxacin"],"drug_indices_start":[33,20],"drug_indices_end":[28,45]}
{"index":500,"text":"Mutations associated with lamivudine-resistance in therapy-na  ve hepatitis B virus (HBV) infected patients with and without HIV co-infection: implications for antiretroviral therapy in HBV and HIV co-infected South African patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis B virus (HBV) infected","HIV co-infection","HBV and HIV co-infected","HBV","HIV"],"disease_indices_start":[66,125,186,194],"disease_indices_end":[98,141,189,197,209],"drugs":["lamivudine","na"],"drug_indices_start":[26,59],"drug_indices_end":[36,61]}
{"index":502,"text":"Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain","acute pain"],"disease_indices_start":[111,146],"disease_indices_end":[115,156],"drugs":["NMDA","morphine","capsaicin"],"drug_indices_start":[81,50,19],"drug_indices_end":[58,90,23]}
{"index":504,"text":"Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria"],"disease_indices_start":[15],"disease_indices_end":[26],"drugs":["sirolimus"],"drug_indices_start":[43],"drug_indices_end":[52]}
{"index":506,"text":"Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["N-pyrimidinyl-2-phenoxyacetamides","adenosine"],"drug_indices_start":[50,13],"drug_indices_end":[59,46]}
{"index":507,"text":"A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 with excellent potency (K(i) = 0.4 nM), selectivity (A(1)\/A(2A) > 100), and efficacy (MED 10 mg\/kg p.o.) in the rat haloperidol-induced catalepsy model for Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy","Parkinson's disease"],"disease_indices_start":[340,360],"disease_indices_end":[349,379],"drugs":["N-pyrimidinyl-2-phenoxyacetamide","adenosine","haloperidol"],"drug_indices_start":[320,98,131],"drug_indices_end":[130,331,140]}
{"index":508,"text":"Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[24],"disease_indices_end":[37],"drugs":["Methamphetamine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":510,"text":"Recovery of tacrolimus-associated brachial neuritis after conversion to everolimus in a pediatric renal transplant recipient--case report and review of the literature.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["brachial neuritis"],"disease_indices_start":[34],"disease_indices_end":[51],"drugs":["tacrolimus","everolimus"],"drug_indices_start":[72,12],"drug_indices_end":[82,22]}
{"index":512,"text":"Valvular heart disease in patients with Parkinson's disease treated with pergolide. Course following treatment modifications.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Valvular heart disease","Parkinson's disease"],"disease_indices_start":[0,40],"disease_indices_end":[22,59],"drugs":["pergolide"],"drug_indices_start":[73],"drug_indices_end":[82]}
{"index":514,"text":"Adverse effects of topical papaverine on auditory nerve function.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["papaverine"],"drug_indices_start":[27],"drug_indices_end":[37]}
{"index":516,"text":"Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental glomerulosclerosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria","acute renal failure","focal segmental glomerulosclerosis"],"disease_indices_start":[8,24,117],"disease_indices_end":[19,43,151],"drugs":["bisphosphonate","alendronate"],"drug_indices_start":[71,55],"drug_indices_end":[82,69]}
{"index":518,"text":"Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotic syndrome"],"disease_indices_start":[68],"disease_indices_end":[86],"drugs":["doxorubicin"],"drug_indices_start":[48],"drug_indices_end":[59]}
{"index":520,"text":"Severe and long lasting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients--a report of two cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cholestasis","Pneumocystis pneumonia","HIV-infected"],"disease_indices_start":[24,81,107],"disease_indices_end":[35,103,119],"drugs":["co-trimoxazole"],"drug_indices_start":[52],"drug_indices_end":[66]}
{"index":522,"text":"Clinically significant proteinuria following the administration of sirolimus to renal transplant recipients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria"],"disease_indices_start":[23],"disease_indices_end":[34],"drugs":["sirolimus"],"drug_indices_start":[67],"drug_indices_end":[76]}
{"index":524,"text":"Comparative cognitive and subjective side effects of immediate-release oxycodone in healthy middle-aged and older adults.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxycodone"],"drug_indices_start":[71],"drug_indices_end":[80]}
{"index":526,"text":"Normalizing effects of modafinil on sleep in chronic cocaine users.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["modafinil","cocaine"],"drug_indices_start":[53,23],"drug_indices_end":[32,60]}
{"index":528,"text":"Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["schizophrenia"],"disease_indices_start":[119],"disease_indices_end":[132],"drugs":["asenapine","haloperidol"],"drug_indices_start":[51,23],"drug_indices_end":[32,62]}
{"index":530,"text":"Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrosis"],"disease_indices_start":[135],"disease_indices_end":[144],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[109],"drug_indices_end":[134]}
{"index":532,"text":"Twin preterm neonates with cardiac toxicity related to lopinavir\/ritonavir therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac toxicity"],"disease_indices_start":[27],"disease_indices_end":[43],"drugs":["lopinavir\/ritonavir"],"drug_indices_start":[55],"drug_indices_end":[74]}
{"index":534,"text":"Learning of rats under amnesia caused by pentobarbital.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[23],"disease_indices_end":[30],"drugs":["pentobarbital"],"drug_indices_start":[41],"drug_indices_end":[54]}
{"index":536,"text":"Angiosarcoma of the liver associated with diethylstilbestrol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Angiosarcoma of the liver","Angiosarcoma","Angiosarcoma of the liver"],"disease_indices_start":[0],"disease_indices_end":[12,25],"drugs":["diethylstilbestrol"],"drug_indices_start":[42],"drug_indices_end":[60]}
{"index":537,"text":"Angiosarcoma of the liver occurred in a 76-year-old man who had been treated for a well-differentiated adenocarcinoma of the liver with diethylstilbestrol for 13 years. Angiosarcoma was also present within pulmonary and renal arteries. The possibility that the intraarterial lesions might represent independent primary tumors is considered.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Angiosarcoma of the liver","Angiosarcoma","Angiosarcoma of the liver","adenocarcinoma of the liver","adenocarcinoma","adenocarcinoma of the liver","Angiosarcoma","intraarterial lesions","tumors"],"disease_indices_start":[62,165,231,323,381],"disease_indices_end":[74,87,179,192,243,344,387],"drugs":["diethylstilbestrol"],"drug_indices_start":[198],"drug_indices_end":[216]}
{"index":538,"text":"Role of xanthine oxidase in dexamethasone-induced hypertension in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[50],"disease_indices_end":[62],"drugs":["xanthine","dexamethasone"],"drug_indices_start":[8,28],"drug_indices_end":[16,41]}
{"index":540,"text":"Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["risperidone","haloperidol"],"drug_indices_start":[33,49],"drug_indices_end":[44,60]}
{"index":542,"text":"Simvastatin-ezetimibe-induced hepatic failure necessitating liver transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatic failure"],"disease_indices_start":[30],"disease_indices_end":[45],"drugs":["Simvastatin-ezetimibe"],"drug_indices_start":[0],"drug_indices_end":[21]}
{"index":544,"text":"Oral manifestations of \"meth mouth\": a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["meth mouth"],"disease_indices_start":[24],"disease_indices_end":[34],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":546,"text":"Thyroxine abuse: an unusual case of thyrotoxicosis in pregnancy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thyrotoxicosis"],"disease_indices_start":[36],"disease_indices_end":[50],"drugs":["Thyroxine"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":548,"text":"Attenuation of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity in mice by lipopolysaccharide pretreatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[66],"disease_indices_end":[79],"drugs":["methamphetamine","lipopolysaccharide"],"drug_indices_start":[91,15],"drug_indices_end":[109,30]}
{"index":550,"text":"Effect of converting enzyme inhibition on the course of adriamycin-induced nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[75],"disease_indices_end":[86],"drugs":["adriamycin"],"drug_indices_start":[56],"drug_indices_end":[66]}
{"index":552,"text":"Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["apnea"],"disease_indices_start":[64],"disease_indices_end":[69],"drugs":["succinylcholine"],"drug_indices_start":[76],"drug_indices_end":[91]}
{"index":554,"text":"Ketamine sedation for the reduction of children's fractures in the emergency department.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["fractures"],"disease_indices_start":[50],"disease_indices_end":[59],"drugs":["Ketamine"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":556,"text":"Prophylactic use of lamivudine with chronic immunosuppressive therapy for rheumatologic disorders.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rheumatologic disorders"],"disease_indices_start":[74],"disease_indices_end":[97],"drugs":["lamivudine"],"drug_indices_start":[20],"drug_indices_end":[30]}
{"index":560,"text":"Effects of calcium channel blockers on bupivacaine-induced toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[59],"disease_indices_end":[67],"drugs":["calcium","bupivacaine"],"drug_indices_start":[11,39],"drug_indices_end":[18,50]}
{"index":562,"text":"Selegiline-induced postural hypotension in Parkinson's disease: a longitudinal study on the effects of drug withdrawal.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["postural hypotension","Parkinson's disease"],"disease_indices_start":[19,43],"disease_indices_end":[39,62],"drugs":["Selegiline"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":564,"text":"Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[84],"disease_indices_end":[88],"drugs":["capsaicin"],"drug_indices_start":[66],"drug_indices_end":[75]}
{"index":566,"text":"Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual case of renovascular hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal insufficiency","renovascular hypertension"],"disease_indices_start":[35,97],"disease_indices_end":[54,122],"drugs":["captopril"],"drug_indices_start":[17],"drug_indices_end":[26]}
{"index":568,"text":"Liver disease caused by propylthiouracil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Liver disease"],"disease_indices_start":[0],"disease_indices_end":[13],"drugs":["propylthiouracil"],"drug_indices_start":[24],"drug_indices_end":[40]}
{"index":569,"text":"This report presents the clinical, laboratory, and light and electron microscopic observations on a patient with chronic active (aggressive) hepatitis caused by the administration of propylthiouracil. This is an addition to the list of drugs that must be considered in the evaluation of chronic liver disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chronic active (aggressive) hepatitis","liver disease"],"disease_indices_start":[155,337],"disease_indices_end":[192,350],"drugs":["propylthiouracil"],"drug_indices_start":[225],"drug_indices_end":[241]}
{"index":570,"text":"Capsaicin-induced muscle pain alters the excitability of the human jaw-stretch reflex.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscle pain"],"disease_indices_start":[18],"disease_indices_end":[29],"drugs":["Capsaicin"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":572,"text":"Repetitive transcranial magnetic stimulation for levodopa-induced dyskinesias in Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias","Parkinson's disease"],"disease_indices_start":[66,81],"disease_indices_end":[77,100],"drugs":["levodopa"],"drug_indices_start":[49],"drug_indices_end":[57]}
{"index":574,"text":"Disulfiram-like syndrome after hydrogen cyanamide professional skin exposure: two case reports in France.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Disulfiram","hydrogen cyanamide"],"drug_indices_start":[0,31],"drug_indices_end":[49,10]}
{"index":576,"text":"Repeated trimipramine induces dopamine D2\/D3 and alpha1-adrenergic up-regulation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trimipramine","dopamine"],"drug_indices_start":[9,30],"drug_indices_end":[21,38]}
{"index":578,"text":"Ranitidine-induced acute interstitial nephritis in a cadaveric renal allograft.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["interstitial nephritis"],"disease_indices_start":[25],"disease_indices_end":[47],"drugs":["Ranitidine"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":580,"text":"Late, late doxorubicin cardiotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[23],"disease_indices_end":[37],"drugs":["doxorubicin"],"drug_indices_start":[11],"drug_indices_end":[22]}
{"index":582,"text":"Acetazolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrolithiasis","neuromuscular disorders"],"disease_indices_start":[22,69],"disease_indices_end":[37,92],"drugs":["Acetazolamide"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":584,"text":"Is the treatment of scabies hazardous?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["scabies"],"disease_indices_start":[20],"disease_indices_end":[27],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":586,"text":"Anaesthetists' nightmare: masseter spasm after induction in an undiagnosed case of myotonia congenita.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["masseter spasm","myotonia congenita"],"disease_indices_start":[26,83],"disease_indices_end":[40,101],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":588,"text":"Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Toxicity"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["8-aminoquinoline","8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline","WR242511"],"drug_indices_start":[154,59,76],"drug_indices_end":[152,162,75]}
{"index":590,"text":"Neuroplasticity of the adult primate auditory cortex following cochlear hearing loss.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hearing loss"],"disease_indices_start":[72],"disease_indices_end":[84],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":592,"text":"The site of common side effects of sumatriptan.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sumatriptan"],"drug_indices_start":[35],"drug_indices_end":[46]}
{"index":594,"text":"Tremor side effects of salbutamol, quantified by a laser pointer technique.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Tremor"],"disease_indices_start":[0],"disease_indices_end":[6],"drugs":["salbutamol"],"drug_indices_start":[23],"drug_indices_end":[33]}
{"index":596,"text":"Increased frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independent prostate cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["venous thromboembolism","prostate cancer"],"disease_indices_start":[23,145],"disease_indices_end":[45,160],"drugs":["docetaxel","thalidomide"],"drug_indices_start":[84,70],"drug_indices_end":[95,79]}
{"index":598,"text":"Sublingual absorption of the quaternary ammonium antiarrhythmic agent, UM-272.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["quaternary ammonium","UM-272"],"drug_indices_start":[29,71],"drug_indices_end":[48,77]}
{"index":600,"text":"Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case report with fatal outcome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia","haemolytic anaemia"],"disease_indices_start":[7,28],"disease_indices_end":[23,46],"drugs":["ciprofloxacin"],"drug_indices_start":[63],"drug_indices_end":[76]}
{"index":602,"text":"Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["compartment syndrome","myonecrosis","hypothyroidism"],"disease_indices_start":[34,59,87],"disease_indices_end":[54,70,101],"drugs":["Simvastatin"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":604,"text":"Bile duct hamartoma occurring in association with long-term treatment with danazol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Bile duct hamartoma","Bile duct hamartoma","hamartoma"],"disease_indices_start":[0,10],"disease_indices_end":[19],"drugs":["danazol"],"drug_indices_start":[75],"drug_indices_end":[82]}
{"index":606,"text":"Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Granulomatous hepatitis","Granulomatous","hepatitis"],"disease_indices_start":[0,14],"disease_indices_end":[13,23],"drugs":["combination of amoxicillin and clavulanic acid"],"drug_indices_start":[31],"drug_indices_end":[77]}
{"index":608,"text":"Intracranial aneurysms and cocaine abuse: analysis of prognostic indicators.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Intracranial aneurysms","cocaine abuse"],"disease_indices_start":[0,27],"disease_indices_end":[22,40],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":610,"text":"Anti-epileptic drugs-induced de novo absence seizures.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epileptic","absence seizures"],"disease_indices_start":[5,37],"disease_indices_end":[14,53],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":612,"text":"Procainamide-induced polymorphous ventricular tachycardia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia"],"disease_indices_start":[34],"disease_indices_end":[57],"drugs":["Procainamide"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":614,"text":"Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[100],"disease_indices_end":[112],"drugs":["bradykinin"],"drug_indices_start":[22],"drug_indices_end":[32]}
{"index":616,"text":"5-azacytidine potentiates initiation induced by carcinogens in rat liver.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["initiation induced by carcinogens"],"disease_indices_start":[26],"disease_indices_end":[59],"drugs":["5-azacytidine"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":618,"text":"Withdrawal-emergent rabbit syndrome during dose reduction of risperidone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Withdrawal-emergent rabbit syndrome","Withdrawal","emergent rabbit syndrome"],"disease_indices_start":[0,11],"disease_indices_end":[10,35],"drugs":["risperidone"],"drug_indices_start":[61],"drug_indices_end":[72]}
{"index":620,"text":"Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction","hypertensive"],"disease_indices_start":[44,71],"disease_indices_end":[65,83],"drugs":["Verapamil"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":622,"text":"Remission induction of meningeal leukemia with high-dose intravenous methotrexate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["meningeal leukemia"],"disease_indices_start":[23],"disease_indices_end":[41],"drugs":["methotrexate"],"drug_indices_start":[69],"drug_indices_end":[81]}
{"index":624,"text":"Hypersensitivity to carbamazepine presenting with a leukemoid reaction, eosinophilia, erythroderma, and renal failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypersensitivity","leukemoid reaction","eosinophilia","erythroderma","renal failure"],"disease_indices_start":[0,52,72,86,104],"disease_indices_end":[16,70,84,98,117],"drugs":["carbamazepine"],"drug_indices_start":[20],"drug_indices_end":[33]}
{"index":625,"text":"We report a patient in whom hypersensitivity to carbamazepine presented with generalized erythroderma, a severe leukemoid reaction, eosinophilia, hyponatremia, and renal failure. This is the first report of such an unusual reaction to carbamazepine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypersensitivity","erythroderma","leukemoid reaction","eosinophilia","hyponatremia","renal failure"],"disease_indices_start":[147,208,231,251,265,283],"disease_indices_end":[163,220,249,263,277,296],"drugs":["carbamazepine","carbamazepine"],"drug_indices_start":[354,167],"drug_indices_end":[180,367]}
{"index":626,"text":"The interpeduncular nucleus regulates nicotine's effects on free-field activity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotine"],"drug_indices_start":[38],"drug_indices_end":[46]}
{"index":628,"text":"Assessment of a new non-invasive index of cardiac performance for detection of dobutamine-induced myocardial ischemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial ischemia"],"disease_indices_start":[98],"disease_indices_end":[117],"drugs":["dobutamine"],"drug_indices_start":[79],"drug_indices_end":[89]}
{"index":630,"text":"Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute liver failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["alcohol","paracetamol"],"drug_indices_start":[49,79],"drug_indices_end":[56,90]}
{"index":632,"text":"Cocaine related chest pain: are we seeing the tip of an iceberg?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chest pain"],"disease_indices_start":[16],"disease_indices_end":[26],"drugs":["Cocaine"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":634,"text":"Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rhabdomyolysis","acute renal failure"],"disease_indices_start":[7,26],"disease_indices_end":[21,45],"drugs":["simvastatin","amiodarone","atazanavir"],"drug_indices_start":[107,91,78],"drug_indices_end":[89,117,101]}
{"index":636,"text":"Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma. European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["squamous cell esophageal carcinoma","Cancer","Cancer"],"disease_indices_start":[44,132,162],"disease_indices_end":[78,138,168],"drugs":["vinorelbine"],"drug_indices_start":[18],"drug_indices_end":[29]}
{"index":638,"text":"Paclitaxel, cisplatin, and gemcitabine combination chemotherapy within a multidisciplinary therapeutic approach in metastatic nonsmall cell lung carcinoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nonsmall cell lung carcinoma"],"disease_indices_start":[126],"disease_indices_end":[154],"drugs":["Paclitaxel","cisplatin","gemcitabine"],"drug_indices_start":[0,27,12],"drug_indices_end":[10,21,38]}
{"index":640,"text":"Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aponidine hydrochloride"],"drug_indices_start":[35],"drug_indices_end":[58]}
{"index":642,"text":"Carmofur-induced organic mental disorders.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["organic mental disorders"],"disease_indices_start":[17],"disease_indices_end":[41],"drugs":["Carmofur"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":644,"text":"International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["arrhythmia"],"disease_indices_start":[81],"disease_indices_end":[91],"drugs":["mexiletine"],"drug_indices_start":[14],"drug_indices_end":[24]}
{"index":646,"text":"Regional localization of the antagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperactivity"],"disease_indices_start":[63],"disease_indices_end":[76],"drugs":["amphetamine","calcitonin"],"drug_indices_start":[43,94],"drug_indices_end":[104,54]}
{"index":648,"text":"Fatal intracranial bleeding associated with prehospital use of epinephrine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["intracranial bleeding"],"disease_indices_start":[6],"disease_indices_end":[27],"drugs":["epinephrine"],"drug_indices_start":[63],"drug_indices_end":[74]}
{"index":650,"text":"A case of massive rhabdomyolysis following molindone administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rhabdomyolysis"],"disease_indices_start":[18],"disease_indices_end":[32],"drugs":["molindone"],"drug_indices_start":[43],"drug_indices_end":[52]}
{"index":652,"text":"Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiovascular alterations"],"disease_indices_start":[0],"disease_indices_end":[26],"drugs":["calcium"],"drug_indices_start":[53],"drug_indices_end":[60]}
{"index":654,"text":"Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lamivudine","hepatitis B virus e antigen"],"drug_indices_start":[106,85],"drug_indices_end":[133,95]}
{"index":656,"text":"The effects of sevoflurane on lidocaine-induced convulsions.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsions"],"disease_indices_start":[48],"disease_indices_end":[59],"drugs":["sevoflurane","lidocaine"],"drug_indices_start":[30,15],"drug_indices_end":[26,39]}
{"index":658,"text":"Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[62],"disease_indices_end":[74],"drugs":["atorvastatin","dexamethasone"],"drug_indices_start":[24,40],"drug_indices_end":[36,53]}
{"index":660,"text":"99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[55],"disease_indices_end":[76],"drugs":["99mTc-glucarate","isoproterenol"],"drug_indices_start":[0,33],"drug_indices_end":[46,15]}
{"index":662,"text":"A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["psychosis","disruptive behaviors","Alzheimer's disease"],"disease_indices_start":[74,88,112],"disease_indices_end":[83,108,131],"drugs":["haloperidol"],"drug_indices_start":[58],"drug_indices_end":[69]}
{"index":664,"text":"Individual differences in renal ACE activity in healthy rats predict susceptibility to adriamycin-induced renal damage.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal damage"],"disease_indices_start":[106],"disease_indices_end":[118],"drugs":["adriamycin"],"drug_indices_start":[87],"drug_indices_end":[97]}
{"index":666,"text":"Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[9],"disease_indices_end":[23],"drugs":["tobramycin","gentamicin"],"drug_indices_start":[42,27],"drug_indices_end":[52,37]}
{"index":668,"text":"Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity","hyperthermia"],"disease_indices_start":[103,185],"disease_indices_end":[116,197],"drugs":["MPEP","methamphetamine","dopamine"],"drug_indices_start":[26,66,150],"drug_indices_end":[81,158,30]}
{"index":670,"text":"Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["desipramine HCl","cinacalcet HCl"],"drug_indices_start":[59,20],"drug_indices_end":[73,35]}
{"index":672,"text":"Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesia"],"disease_indices_start":[75],"disease_indices_end":[85],"drugs":["L-DOPA"],"drug_indices_start":[60],"drug_indices_end":[66]}
{"index":674,"text":"Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["allergic reactions"],"disease_indices_start":[7],"disease_indices_end":[25],"drugs":["corticosteroids"],"drug_indices_start":[29],"drug_indices_end":[44]}
{"index":676,"text":"Valproic acid induced encephalopathy--19 new cases in Germany from 1994 to 2003--a side effect associated to VPA-therapy not only in young children.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalopathy"],"disease_indices_start":[22],"disease_indices_end":[36],"drugs":["Valproic acid","VPA"],"drug_indices_start":[0,109],"drug_indices_end":[112,13]}
{"index":678,"text":"Haemolytic-uraemic syndrome after treatment with metronidazole.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Haemolytic-uraemic syndrome"],"disease_indices_start":[0],"disease_indices_end":[27],"drugs":["metronidazole"],"drug_indices_start":[49],"drug_indices_end":[62]}
{"index":680,"text":"Risk factors of sensorineural hearing loss in preterm infants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sensorineural hearing loss"],"disease_indices_start":[16],"disease_indices_end":[42],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":682,"text":"Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["confusion"],"disease_indices_start":[83],"disease_indices_end":[92],"drugs":["cimetidine"],"drug_indices_start":[54],"drug_indices_end":[64]}
{"index":684,"text":"Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["intrahepatic and extrahepatic cholestasis","intrahepatic","extrahepatic cholestasis"],"disease_indices_start":[87,104],"disease_indices_end":[99,128],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":686,"text":"Long term audiological evaluation of beta-thalassemic patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["beta-thalassemic"],"disease_indices_start":[37],"disease_indices_end":[53],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":688,"text":"Design and analysis of the HYPREN-trial: safety of enalapril and prazosin in the initial treatment phase of patients with congestive heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["congestive heart failure"],"disease_indices_start":[122],"disease_indices_end":[146],"drugs":["enalapril","prazosin"],"drug_indices_start":[65,51],"drug_indices_end":[73,60]}
{"index":690,"text":"Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anemia"],"disease_indices_start":[88],"disease_indices_end":[94],"drugs":["azidothymidine"],"drug_indices_start":[65],"drug_indices_end":[79]}
{"index":692,"text":"Interactive effects of variations in [Na]o and [Ca]o on rat atrial spontaneous frequency.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Na","Ca"],"drug_indices_start":[48,38],"drug_indices_end":[40,50]}
{"index":694,"text":"Sodium status influences chronic amphotericin B nephrotoxicity in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[48],"disease_indices_end":[62],"drugs":["Sodium","amphotericin B"],"drug_indices_start":[0,33],"drug_indices_end":[6,47]}
{"index":696,"text":"Reversible inferior colliculus lesion in metronidazole-induced encephalopathy: magnetic resonance findings on diffusion-weighted and fluid attenuated inversion recovery imaging.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["inferior colliculus lesion","encephalopathy"],"disease_indices_start":[11,63],"disease_indices_end":[37,77],"drugs":["metronidazole"],"drug_indices_start":[41],"drug_indices_end":[54]}
{"index":698,"text":"Comparison of the respiratory effects of i.v. infusions of morphine and regional analgesia by extradural block.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["morphine"],"drug_indices_start":[59],"drug_indices_end":[67]}
{"index":700,"text":"Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epileptic","overdosages"],"disease_indices_start":[50,85],"disease_indices_end":[59,96],"drugs":["phenytoin"],"drug_indices_start":[75],"drug_indices_end":[84]}
{"index":702,"text":"Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial damage","cardiomyopathy"],"disease_indices_start":[60,101],"disease_indices_end":[77,115],"drugs":["doxorubicin"],"drug_indices_start":[81],"drug_indices_end":[92]}
{"index":704,"text":"Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain","CIPS"],"disease_indices_start":[30,45],"disease_indices_end":[34,49],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":706,"text":"The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propofol","ephedrine"],"drug_indices_start":[57,28],"drug_indices_end":[66,36]}
{"index":708,"text":"Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Neurotoxicity"],"disease_indices_start":[0],"disease_indices_end":[13],"drugs":["halogenated hydroxyquinolines"],"drug_indices_start":[17],"drug_indices_end":[46]}
{"index":710,"text":"Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Epileptic seizures"],"disease_indices_start":[0],"disease_indices_end":[18],"drugs":["tranexamic acid"],"drug_indices_start":[80],"drug_indices_end":[95]}
{"index":712,"text":"A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sugar dependency","behavioral cross-sensitization"],"disease_indices_start":[17,41],"disease_indices_end":[33,71],"drugs":["amphetamine"],"drug_indices_start":[89],"drug_indices_end":[100]}
{"index":714,"text":"D-penicillamine-induced angiopathy in rats. The effect of high dose D-penicillamine treatment on aortic permeability to albumin and on the ultrastructure of the vessel.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["angiopathy"],"disease_indices_start":[24],"disease_indices_end":[34],"drugs":["D-penicillamine","D-penicillamine"],"drug_indices_start":[0,68],"drug_indices_end":[83,15]}
{"index":716,"text":"Brain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[66],"disease_indices_end":[80],"drugs":["anthracycline"],"drug_indices_start":[44],"drug_indices_end":[57]}
{"index":718,"text":"Antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["birth defects","Birth Defects"],"disease_indices_start":[58,82],"disease_indices_end":[71,95],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":720,"text":"Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neoplasms","rheumatoid arthritis"],"disease_indices_start":[13,40],"disease_indices_end":[22,60],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":722,"text":"Patterns of hepatic injury induced by methyldopa.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatic injury"],"disease_indices_start":[12],"disease_indices_end":[26],"drugs":["methyldopa"],"drug_indices_start":[38],"drug_indices_end":[48]}
{"index":724,"text":"A phase I\/II study of paclitaxel plus cisplatin as first-line therapy for head and neck cancers: preliminary results.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["head and neck cancers"],"disease_indices_start":[74],"disease_indices_end":[95],"drugs":["paclitaxel","cisplatin"],"drug_indices_start":[38,22],"drug_indices_end":[32,47]}
{"index":726,"text":"A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["4'-0-tetrahydropyranyladriamycin"],"drug_indices_start":[19],"drug_indices_end":[51]}
{"index":728,"text":"Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[91],"disease_indices_end":[99],"drugs":["gamma-hexachlorocyclohexane","lindane"],"drug_indices_start":[24,53],"drug_indices_end":[51,60]}
{"index":730,"text":"Severe ocular and orbital toxicity after intracarotid injection of carboplatin for recurrent glioblastomas.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ocular and orbital toxicity","ocular","orbital toxicity","glioblastomas"],"disease_indices_start":[7,18,93],"disease_indices_end":[13,34,106],"drugs":["carboplatin"],"drug_indices_start":[67],"drug_indices_end":[78]}
{"index":732,"text":"Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["non-small cell lung cancer"],"disease_indices_start":[64],"disease_indices_end":[90],"drugs":["amsacrine","CI-921","NSC 343499"],"drug_indices_start":[41,22,49],"drug_indices_end":[59,47,31]}
{"index":734,"text":"Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mitochondrial damage","neurotoxicity","neuropathy"],"disease_indices_start":[27,52,95],"disease_indices_end":[47,65,105],"drugs":["Alpha-lipoic acid"],"drug_indices_start":[0],"drug_indices_end":[17]}
{"index":736,"text":"Optimising stroke prevention in non-valvular atrial fibrillation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["stroke","atrial fibrillation"],"disease_indices_start":[11,45],"disease_indices_end":[17,64],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":738,"text":"Interaction of cyclosporin A with antineoplastic agents.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporin A"],"drug_indices_start":[15],"drug_indices_end":[28]}
{"index":740,"text":"The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hematotoxicity"],"disease_indices_start":[99],"disease_indices_end":[113],"drugs":["cefonicid","cefazedone","cephalosporin"],"drug_indices_start":[41,27,85],"drug_indices_end":[98,51,36]}
{"index":742,"text":"A pyridoxine-dependent behavioral disorder unmasked by isoniazid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["behavioral disorder"],"disease_indices_start":[23],"disease_indices_end":[42],"drugs":["pyridoxine","isoniazid"],"drug_indices_start":[2,55],"drug_indices_end":[64,12]}
{"index":744,"text":"A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dopamine","NRA0160"],"drug_indices_start":[12,45],"drug_indices_end":[20,52]}
{"index":746,"text":"Prolonged cholestasis after troleandomycin-induced acute hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cholestasis","hepatitis"],"disease_indices_start":[10,57],"disease_indices_end":[21,66],"drugs":["troleandomycin"],"drug_indices_start":[28],"drug_indices_end":[42]}
{"index":750,"text":"Sulfasalazine-induced lupus erythematosus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["lupus erythematosus"],"disease_indices_start":[22],"disease_indices_end":[41],"drugs":["Sulfasalazine"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":752,"text":"Optimization of levodopa therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["levodopa"],"drug_indices_start":[16],"drug_indices_end":[24]}
{"index":754,"text":"Alpha and beta coma in drug intoxication uncomplicated by cerebral hypoxia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coma","cerebral hypoxia"],"disease_indices_start":[15,58],"disease_indices_end":[19,74],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":756,"text":"Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nausea","vomiting","pain"],"disease_indices_start":[26,37,66],"disease_indices_end":[32,45,70],"drugs":["fentanyl","sevoflurane"],"drug_indices_start":[9,78],"drug_indices_end":[89,17]}
{"index":758,"text":"Renal Fanconi syndrome and myopathy after liver transplantation: drug-related mitochondrial cytopathy?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Renal Fanconi syndrome","myopathy","mitochondrial cytopathy"],"disease_indices_start":[0,27,78],"disease_indices_end":[22,35,101],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":760,"text":"Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["thioperamide"],"drug_indices_start":[30],"drug_indices_end":[42]}
{"index":762,"text":"Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["platypnea-orthodeoxia-like syndrome","overdose","Ebstein's anomaly"],"disease_indices_start":[10,69,100],"disease_indices_end":[45,77,117],"drugs":["propafenone"],"drug_indices_start":[57],"drug_indices_end":[68]}
{"index":764,"text":"A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast carcinoma"],"disease_indices_start":[71],"disease_indices_end":[87],"drugs":["cisplatin","WR-2721","amifostine"],"drug_indices_start":[35,20,44],"drug_indices_end":[42,29,54]}
{"index":766,"text":"Warfarin-induced iliopsoas hemorrhage with subsequent femoral nerve palsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhage","femoral nerve palsy"],"disease_indices_start":[27,54],"disease_indices_end":[37,73],"drugs":["Warfarin"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":768,"text":"Myasthenia gravis caused by penicillamine and chloroquine therapy for rheumatoid arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Myasthenia gravis","rheumatoid arthritis"],"disease_indices_start":[0,70],"disease_indices_end":[17,90],"drugs":["penicillamine","chloroquine"],"drug_indices_start":[28,46],"drug_indices_end":[41,57]}
{"index":769,"text":"We have described a unique patient who had reversible and dose-related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis. Although acetylcholine receptor antibodies were not detectable, the time course was consistent with an autoimmune process.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myasthenia gravis","rheumatoid arthritis"],"disease_indices_start":[163,229],"disease_indices_end":[180,249],"drugs":["penicillamine","chloroquine","acetylcholine"],"drug_indices_start":[187,260,205],"drug_indices_end":[200,273,216]}
{"index":770,"text":"Nephrotoxicity of combined cephalothin-gentamicin regimen.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Nephrotoxicity"],"disease_indices_start":[0],"disease_indices_end":[14],"drugs":["cephalothin","gentamicin"],"drug_indices_start":[27,39],"drug_indices_end":[49,38]}
{"index":772,"text":"Components of lemon essential oil attenuate dementia induced by scopolamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dementia"],"disease_indices_start":[44],"disease_indices_end":[52],"drugs":["scopolamine"],"drug_indices_start":[64],"drug_indices_end":[75]}
{"index":774,"text":"The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["memory deficiency"],"disease_indices_start":[120],"disease_indices_end":[137],"drugs":["Ro4368554"],"drug_indices_start":[40],"drug_indices_end":[49]}
{"index":776,"text":"Lone atrial fibrillation associated with creatine monohydrate supplementation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrial fibrillation"],"disease_indices_start":[5],"disease_indices_end":[24],"drugs":["creatine"],"drug_indices_start":[41],"drug_indices_end":[49]}
{"index":778,"text":"Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[28],"disease_indices_end":[36],"drugs":["DFU","piroxicam"],"drug_indices_start":[125,133],"drug_indices_end":[128,142]}
{"index":780,"text":"Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[68],"disease_indices_end":[76],"drugs":["steroids","cocaine"],"drug_indices_start":[35,52],"drug_indices_end":[59,43]}
{"index":782,"text":"Kidney function and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclosporine A","tacrolimus","sirolimus"],"drug_indices_start":[89,73,104],"drug_indices_end":[113,99,87]}
{"index":784,"text":"Effect of fucoidan treatment on collagenase-induced intracerebral hemorrhage in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["intracerebral hemorrhage"],"disease_indices_start":[52],"disease_indices_end":[76],"drugs":["fucoidan"],"drug_indices_start":[10],"drug_indices_end":[18]}
{"index":786,"text":"Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coma","metabolic acidosis","renal and hepatic failure","renal","hepatic failure"],"disease_indices_start":[23,29,49,59],"disease_indices_end":[27,47,54,74],"drugs":["Paracetamol"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":787,"text":"A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of maintaining fluid and electrolyte balance. The patient recovered.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["metabolic acidosis","acute renal failure and hepatic failure","acute renal failure","acute"],"disease_indices_start":[86,106],"disease_indices_end":[104,111,125,145],"drugs":["paracetamol"],"drug_indices_start":[156],"drug_indices_end":[167]}
{"index":788,"text":"Hepatic reactions associated with ketoconazole in the United Kingdom.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ketoconazole"],"drug_indices_start":[34],"drug_indices_end":[46]}
{"index":790,"text":"Combined effects of prolonged prostaglandin E1-induced hypotension and haemodilution on human hepatic function.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","haemodilution"],"disease_indices_start":[55,71],"disease_indices_end":[66,84],"drugs":["prostaglandin E1"],"drug_indices_start":[30],"drug_indices_end":[46]}
{"index":792,"text":"Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias","Parkinson's disease"],"disease_indices_start":[17,46],"disease_indices_end":[28,65],"drugs":["Levodopa"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":794,"text":"Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures","epilepsy"],"disease_indices_start":[14,142],"disease_indices_end":[22,150],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":796,"text":"Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[71],"disease_indices_end":[92],"drugs":["salvianolic acid A","isoproterenol"],"drug_indices_start":[49,27],"drug_indices_end":[45,62]}
{"index":798,"text":"Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure"],"disease_indices_start":[110],"disease_indices_end":[117],"drugs":["N-(2-propylpentanoyl)urea","amino acid","pilocarpine"],"drug_indices_start":[17,58,90],"drug_indices_end":[42,68,101]}
{"index":800,"text":"Acute hepatitis attack after exposure to telithromycin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis"],"disease_indices_start":[6],"disease_indices_end":[15],"drugs":["telithromycin"],"drug_indices_start":[41],"drug_indices_end":[54]}
{"index":802,"text":"Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal insufficiency","hyperkalemia","heart failure"],"disease_indices_start":[23,47,77],"disease_indices_end":[42,59,90],"drugs":["Spironolactone"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":804,"text":"End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["End-stage renal disease","ESRD"],"disease_indices_start":[0,25],"disease_indices_end":[23,29],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":806,"text":"Effect of intravenous nimodipine on blood pressure and outcome after acute stroke.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute stroke"],"disease_indices_start":[69],"disease_indices_end":[81],"drugs":["nimodipine"],"drug_indices_start":[22],"drug_indices_end":[32]}
{"index":808,"text":"Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Transient neurologic symptoms"],"disease_indices_start":[0],"disease_indices_end":[29],"drugs":["prilocaine","bupivacaine","lidocaine"],"drug_indices_start":[115,93,78],"drug_indices_end":[88,124,104]}
{"index":810,"text":"The role of nicotine in smoking-related cardiovascular disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiovascular disease"],"disease_indices_start":[40],"disease_indices_end":[62],"drugs":["nicotine"],"drug_indices_start":[12],"drug_indices_end":[20]}
{"index":812,"text":"Seizure resulting from a venlafaxine overdose.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Seizure","overdose"],"disease_indices_start":[0,37],"disease_indices_end":[7,45],"drugs":["venlafaxine"],"drug_indices_start":[25],"drug_indices_end":[36]}
{"index":814,"text":"Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nifedipine","tacrolimus"],"drug_indices_start":[80,10],"drug_indices_end":[90,20]}
{"index":816,"text":"Sinus arrest associated with continuous-infusion cimetidine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Sinus arrest"],"disease_indices_start":[0],"disease_indices_end":[12],"drugs":["cimetidine"],"drug_indices_start":[49],"drug_indices_end":[59]}
{"index":818,"text":"Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic acid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gall bladder stones"],"disease_indices_start":[15],"disease_indices_end":[34],"drugs":["octreotide","ursodeoxycholic acid"],"drug_indices_start":[80,51],"drug_indices_end":[100,61]}
{"index":820,"text":"Cardiovascular complications associated with terbutaline treatment for preterm labor.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiovascular complications","preterm labor"],"disease_indices_start":[0,71],"disease_indices_end":[28,84],"drugs":["terbutaline"],"drug_indices_start":[45],"drug_indices_end":[56]}
{"index":821,"text":"Severe cardiovascular complications occurred in eight of 160 patients treated with terbutaline for preterm labor. Associated corticosteroid therapy and twin gestations appear to be predisposing factors. Potential mechanisms of the pathophysiology are briefly discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiovascular complications","preterm labor"],"disease_indices_start":[93,185],"disease_indices_end":[121,198],"drugs":["terbutaline"],"drug_indices_start":[169],"drug_indices_end":[180]}
{"index":822,"text":"Neurologic effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["2-chloroprocaine-CE","bupivacaine"],"drug_indices_start":[74,53],"drug_indices_end":[72,85]}
{"index":824,"text":"Early adjuvant adriamycin in superficial bladder carcinoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bladder carcinoma","bladder carcinoma","carcinoma"],"disease_indices_start":[41,49],"disease_indices_end":[58],"drugs":["adriamycin"],"drug_indices_start":[15],"drug_indices_end":[25]}
{"index":826,"text":"Hyperkalemia associated with sulindac therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperkalemia"],"disease_indices_start":[0],"disease_indices_end":[12],"drugs":["sulindac"],"drug_indices_start":[29],"drug_indices_end":[37]}
{"index":828,"text":"Ventricular tachyarrhythmias during cesarean section after ritodrine therapy: interaction with anesthetics.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Ventricular tachyarrhythmias"],"disease_indices_start":[0],"disease_indices_end":[28],"drugs":["ritodrine"],"drug_indices_start":[59],"drug_indices_end":[68]}
{"index":830,"text":"Immunohistochemical, electron microscopic and morphometric studies of estrogen-induced rat prolactinomas after bromocriptine treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["prolactinomas"],"disease_indices_start":[91],"disease_indices_end":[104],"drugs":["estrogen","bromocriptine"],"drug_indices_start":[70,111],"drug_indices_end":[124,78]}
{"index":832,"text":"On two paradoxical side-effects of prednisolone in rats, ribosomal RNA biosyntheses, and a mechanism of action.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prednisolone"],"drug_indices_start":[35],"drug_indices_end":[47]}
{"index":834,"text":"Possible intramuscular midazolam-associated cardiorespiratory arrest and death.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiorespiratory arrest","death"],"disease_indices_start":[44,73],"disease_indices_end":[68,78],"drugs":["midazolam"],"drug_indices_start":[23],"drug_indices_end":[32]}
{"index":836,"text":"Serial epilepsy caused by levodopa\/carbidopa administration in two patients on hemodialysis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epilepsy"],"disease_indices_start":[7],"disease_indices_end":[15],"drugs":["levodopa\/carbidopa"],"drug_indices_start":[26],"drug_indices_end":[44]}
{"index":838,"text":"Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[48],"disease_indices_end":[55],"drugs":["L-alpha-glyceryl-phosphorylcholine","scopolamine"],"drug_indices_start":[10,66],"drug_indices_end":[44,77]}
{"index":840,"text":"Seizures induced by the cocaine metabolite benzoylecgonine in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Seizures"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["cocaine","benzoylecgonine"],"drug_indices_start":[24,43],"drug_indices_end":[58,31]}
{"index":842,"text":"Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[39],"disease_indices_end":[52],"drugs":["amphetamine","dopamine","LY274614","amino acid"],"drug_indices_start":[124,19,100,69],"drug_indices_end":[134,108,77,30]}
{"index":844,"text":"Neonatal pyridoxine responsive convulsions due to isoniazid therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsions"],"disease_indices_start":[31],"disease_indices_end":[42],"drugs":["pyridoxine","isoniazid"],"drug_indices_start":[9,50],"drug_indices_end":[59,19]}
{"index":846,"text":"Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute myocardial infarction"],"disease_indices_start":[98],"disease_indices_end":[125],"drugs":["phenylephrine","nitroglycerin"],"drug_indices_start":[67,12],"drug_indices_end":[80,25]}
{"index":848,"text":"Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thoracic aortic aneurysm"],"disease_indices_start":[103],"disease_indices_end":[127],"drugs":["CaCl2"],"drug_indices_start":[89],"drug_indices_end":[94]}
{"index":852,"text":"Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["peripheral neurotoxicity"],"disease_indices_start":[62],"disease_indices_end":[86],"drugs":["glutamate","paclitaxel"],"drug_indices_start":[10,90],"drug_indices_end":[19,100]}
{"index":854,"text":"Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain","hyperalgesia"],"disease_indices_start":[36,82],"disease_indices_end":[40,94],"drugs":["capsaicin"],"drug_indices_start":[54],"drug_indices_end":[63]}
{"index":856,"text":"Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[23],"disease_indices_end":[35],"drugs":["Testosterone","salt"],"drug_indices_start":[0,91],"drug_indices_end":[12,95]}
{"index":858,"text":"Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dopamine"],"drug_indices_start":[36],"drug_indices_end":[44]}
{"index":860,"text":"mToR inhibitors-induced proteinuria: mechanisms, significance, and management.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria"],"disease_indices_start":[24],"disease_indices_end":[35],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":862,"text":"Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperprolactinemic"],"disease_indices_start":[92],"disease_indices_end":[110],"drugs":["ribonucleic acid","estradiol"],"drug_indices_start":[42,182],"drug_indices_end":[58,191]}
{"index":864,"text":"Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cholesteryl ester","ritonavir"],"drug_indices_start":[18,102],"drug_indices_end":[35,111]}
{"index":866,"text":"Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure"],"disease_indices_start":[90],"disease_indices_end":[97],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":868,"text":"Use of chromosome substitution strains to identify seizure susceptibility loci in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure"],"disease_indices_start":[51],"disease_indices_end":[58],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":870,"text":"Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epilepsy"],"disease_indices_start":[72],"disease_indices_end":[80],"drugs":["pilocarpine"],"drug_indices_start":[92],"drug_indices_end":[103]}
{"index":872,"text":"Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombotic microangiopathy"],"disease_indices_start":[16],"disease_indices_end":[42],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":874,"text":"Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["left ventricular systolic and diastolic dysfunction","overdose"],"disease_indices_start":[18,111],"disease_indices_end":[69,119],"drugs":["epinephrine"],"drug_indices_start":[99],"drug_indices_end":[110]}
{"index":876,"text":"Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Urinary bladder cancer","Wegener's granulomatosis"],"disease_indices_start":[0,26],"disease_indices_end":[22,50],"drugs":["cyclophosphamide"],"drug_indices_start":[74],"drug_indices_end":[90]}
{"index":878,"text":"L-arginine transport in humans with cortisol-induced hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[53],"disease_indices_end":[65],"drugs":["L-arginine","cortisol"],"drug_indices_start":[0,36],"drug_indices_end":[10,44]}
{"index":880,"text":"MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[69],"disease_indices_end":[82],"drugs":["tacrolimus"],"drug_indices_start":[50],"drug_indices_end":[60]}
{"index":882,"text":"Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypoxemia","pulmonary hypertension"],"disease_indices_start":[19,33],"disease_indices_end":[28,55],"drugs":["Octreotide"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":884,"text":"Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["exencephaly","exencephaly","anencephaly"],"disease_indices_start":[27,164,179],"disease_indices_end":[38,175,190],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":886,"text":"Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[22],"disease_indices_end":[30],"drugs":["cocaine"],"drug_indices_start":[6],"drug_indices_end":[13]}
{"index":888,"text":"Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Microangiopathic hemolytic anemia"],"disease_indices_start":[0],"disease_indices_end":[33],"drugs":["FK506","tacrolimus"],"drug_indices_start":[54,47],"drug_indices_end":[64,52]}
{"index":890,"text":"Variant ventricular tachycardia in desipramine toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia","toxicity"],"disease_indices_start":[8,47],"disease_indices_end":[31,55],"drugs":["desipramine"],"drug_indices_start":[35],"drug_indices_end":[46]}
{"index":892,"text":"Desipramine-induced delirium at \"subtherapeutic\" concentrations: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["delirium"],"disease_indices_start":[20],"disease_indices_end":[28],"drugs":["Desipramine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":894,"text":"Mouse strain-dependent effect of amantadine on motility and brain biogenic amines.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amantadine","amines"],"drug_indices_start":[33,75],"drug_indices_end":[81,43]}
{"index":896,"text":"No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["phenobarbital","choline"],"drug_indices_start":[18,66],"drug_indices_end":[73,31]}
{"index":898,"text":"Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["variant angina"],"disease_indices_start":[95],"disease_indices_end":[109],"drugs":["methylergonovine"],"drug_indices_start":[49],"drug_indices_end":[65]}
{"index":900,"text":"Dobutamine stress echocardiography: a sensitive indicator of diminished myocardial function in asymptomatic doxorubicin-treated long-term survivors of childhood cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cancer"],"disease_indices_start":[161],"disease_indices_end":[167],"drugs":["Dobutamine","doxorubicin"],"drug_indices_start":[0,108],"drug_indices_end":[10,119]}
{"index":902,"text":"Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular fibrillation","respiratory failure"],"disease_indices_start":[57,89],"disease_indices_end":[81,108],"drugs":["aminophylline"],"drug_indices_start":[11],"drug_indices_end":[24]}
{"index":904,"text":"Case report: acute unintentional carbachol intoxication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbachol"],"drug_indices_start":[33],"drug_indices_end":[42]}
{"index":906,"text":"Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine\/caffeine in migraine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["migraine"],"disease_indices_start":[100],"disease_indices_end":[108],"drugs":["rizatriptan","ergotamine","caffeine"],"drug_indices_start":[88,52,77],"drug_indices_end":[96,87,63]}
{"index":908,"text":"Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Thrombotic microangiopathy","renal failure"],"disease_indices_start":[0,31],"disease_indices_end":[26,44],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":910,"text":"Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed\/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["T-cell lymphoblastic leukaemia and lymphoma","T-cell lymphoblastic leukaemia","T-cell lymphoblastic"],"disease_indices_start":[99],"disease_indices_end":[119,129,142],"drugs":["nelarabine","etoposide","cyclophosphamide"],"drug_indices_start":[48,33,21],"drug_indices_end":[64,42,31]}
{"index":912,"text":"The 3-week sulphasalazine syndrome strikes again.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["sulphasalazine"],"drug_indices_start":[11],"drug_indices_end":[25]}
{"index":914,"text":"Bupropion (Zyban) toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[18],"disease_indices_end":[26],"drugs":["Bupropion","Zyban"],"drug_indices_start":[0,11],"drug_indices_end":[16,9]}
{"index":916,"text":"Survey of complications of indocyanine green angiography in Japan.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["indocyanine green"],"drug_indices_start":[27],"drug_indices_end":[44]}
{"index":918,"text":"Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperalgesia","diabetic neuropathy"],"disease_indices_start":[112,145],"disease_indices_end":[124,164],"drugs":["Bradykinin","nitric oxide","vincristine","streptozotocin"],"drug_indices_start":[0,73,37,89],"drug_indices_end":[49,10,84,103]}
{"index":920,"text":"Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiac toxicity","breast cancer"],"disease_indices_start":[0,107],"disease_indices_end":[16,120],"drugs":["cyclophosphamide"],"drug_indices_start":[56],"drug_indices_end":[72]}
{"index":922,"text":"Inappropriate use of carbamazepine and vigabatrin in typical absence seizures.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["absence seizures"],"disease_indices_start":[61],"disease_indices_end":[77],"drugs":["carbamazepine","vigabatrin"],"drug_indices_start":[21,39],"drug_indices_end":[49,34]}
{"index":924,"text":"Hemolytic anemia associated with the use of omeprazole.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hemolytic anemia"],"disease_indices_start":[0],"disease_indices_end":[16],"drugs":["omeprazole"],"drug_indices_start":[44],"drug_indices_end":[54]}
{"index":926,"text":"The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intolerant to zidovudine (AZT)","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity","HIV antibody-positive"],"disease_indices_start":[12,44],"disease_indices_end":[20,65],"drugs":["didanosine","ddI","zidovudine","AZT"],"drug_indices_start":[24,36,104,92],"drug_indices_end":[34,107,102,39]}
{"index":928,"text":"Can angiogenesis be a target of treatment for ribavirin associated hemolytic anemia?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolytic anemia"],"disease_indices_start":[67],"disease_indices_end":[83],"drugs":["ribavirin"],"drug_indices_start":[46],"drug_indices_end":[55]}
{"index":930,"text":"Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["memory and learning impairments","memory","learning impairments"],"disease_indices_start":[15,26],"disease_indices_end":[21,46],"drugs":["Cocaine","topiramate"],"drug_indices_start":[0,134],"drug_indices_end":[144,7]}
{"index":932,"text":"Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["PG-9"],"drug_indices_start":[84],"drug_indices_end":[88]}
{"index":934,"text":"Hyperbaric oxygen therapy for control of intractable cyclophosphamide-induced hemorrhagic cystitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhagic cystitis","hemorrhagic","cystitis"],"disease_indices_start":[78,90],"disease_indices_end":[89,98],"drugs":["oxygen","cyclophosphamide"],"drug_indices_start":[11,53],"drug_indices_end":[17,69]}
{"index":940,"text":"Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive dysfunction"],"disease_indices_start":[21],"disease_indices_end":[42],"drugs":["Curcumin","phenobarbitone","carbamazepine"],"drug_indices_start":[0,67,86],"drug_indices_end":[8,81,99]}
{"index":942,"text":"Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["status epilepticus"],"disease_indices_start":[76],"disease_indices_end":[94],"drugs":["Pyrrolidine dithiocarbamate","pilocarpine"],"drug_indices_start":[0,64],"drug_indices_end":[75,27]}
{"index":944,"text":"Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers with underlying medical conditions: a 12-week, randomized, open-label study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["nicotine","nicotine"],"drug_indices_start":[59,20],"drug_indices_end":[67,28]}
{"index":946,"text":"Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and\/or duration of symptoms.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias","parkinsonian"],"disease_indices_start":[32,47],"disease_indices_end":[43,59],"drugs":["levodopa"],"drug_indices_start":[15],"drug_indices_end":[23]}
{"index":948,"text":"Propylthiouracil-induced perinuclear-staining antineutrophil cytoplasmic autoantibody-positive vasculitis in conjunction with pericarditis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vasculitis","pericarditis"],"disease_indices_start":[95,126],"disease_indices_end":[105,138],"drugs":["Propylthiouracil"],"drug_indices_start":[0],"drug_indices_end":[16]}
{"index":950,"text":"Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[82],"disease_indices_end":[90],"drugs":["beta-carboline","GABA"],"drug_indices_start":[169,59],"drug_indices_end":[73,173]}
{"index":952,"text":"Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cancer"],"disease_indices_start":[44],"disease_indices_end":[50],"drugs":["ketamine","morphine"],"drug_indices_start":[32,63],"drug_indices_end":[40,71]}
{"index":954,"text":"Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["erectile dysfunction"],"disease_indices_start":[38],"disease_indices_end":[58],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":956,"text":"Thiopentone pretreatment for propofol injection pain in ambulatory patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[48],"disease_indices_end":[52],"drugs":["Thiopentone","propofol"],"drug_indices_start":[0,29],"drug_indices_end":[11,37]}
{"index":958,"text":"Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia","arrhythmias"],"disease_indices_start":[68,84],"disease_indices_end":[79,95],"drugs":["glycopyrrolate","atropine","suxamethonium"],"drug_indices_start":[19,124,38],"drug_indices_end":[33,137,46]}
{"index":960,"text":"Reduction in caffeine toxicity by acetaminophen.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[22],"disease_indices_end":[30],"drugs":["caffeine","acetaminophen"],"drug_indices_start":[34,13],"drug_indices_end":[21,47]}
{"index":962,"text":"Flestolol: an ultra-short-acting beta-adrenergic blocking agent.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Flestolol"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":964,"text":"Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrosclerosis","renovascular hypertension"],"disease_indices_start":[62,91],"disease_indices_end":[77,116],"drugs":["calcium","nitrendipine"],"drug_indices_start":[46,22],"drug_indices_end":[58,29]}
{"index":966,"text":"Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tinnitus"],"disease_indices_start":[13],"disease_indices_end":[21],"drugs":["lignocaine","lidocaine"],"drug_indices_start":[67,55],"drug_indices_end":[65,76]}
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{"index":1256,"text":"Use of propranolol in the treatment of idiopathic orthostatic hypotension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["idiopathic orthostatic hypotension"],"disease_indices_start":[39],"disease_indices_end":[73],"drugs":["propranolol"],"drug_indices_start":[7],"drug_indices_end":[18]}
{"index":1258,"text":"Total intravenous anesthesia with etomidate. III. Some observations in adults.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["etomidate"],"drug_indices_start":[34],"drug_indices_end":[43]}
{"index":1260,"text":"A method for the measurement of tremor, and a comparison of the effects of tocolytic beta-mimetics.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tremor"],"disease_indices_start":[32],"disease_indices_end":[38],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1262,"text":"Bilateral retinal artery and choriocapillaris occlusion following the injection of long-acting corticosteroid suspensions in combination with other drugs: I. Clinical studies.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retinal artery and choriocapillaris occlusion"],"disease_indices_start":[10],"disease_indices_end":[55],"drugs":["corticosteroid"],"drug_indices_start":[95],"drug_indices_end":[109]}
{"index":1264,"text":"Cephalothin-induced immune hemolytic anemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolytic anemia"],"disease_indices_start":[27],"disease_indices_end":[43],"drugs":["Cephalothin"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1266,"text":"Kaliuretic effect of L-dopa treatment in parkinsonian patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["parkinsonian"],"disease_indices_start":[41],"disease_indices_end":[53],"drugs":["L-dopa"],"drug_indices_start":[21],"drug_indices_end":[27]}
{"index":1268,"text":"Phenytoin encephalopathy as probable idiosyncratic reaction: case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalopathy"],"disease_indices_start":[10],"disease_indices_end":[24],"drugs":["Phenytoin"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1270,"text":"Effects of exercise on the severity of isoproterenol-induced myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[61],"disease_indices_end":[82],"drugs":["isoproterenol"],"drug_indices_start":[39],"drug_indices_end":[52]}
{"index":1272,"text":"Effect of D-Glucarates on basic antibiotic-induced renal damage in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal damage"],"disease_indices_start":[51],"disease_indices_end":[63],"drugs":["D-Glucarates"],"drug_indices_start":[10],"drug_indices_end":[22]}
{"index":1274,"text":"Paraplegia following intrathecal methotrexate: report of a case and review of the literature.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Paraplegia"],"disease_indices_start":[0],"disease_indices_end":[10],"drugs":["methotrexate"],"drug_indices_start":[33],"drug_indices_end":[45]}
{"index":1276,"text":"Centrally mediated cardiovascular effects of intracisternal application of carbachol in anesthetized rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["carbachol"],"drug_indices_start":[75],"drug_indices_end":[84]}
{"index":1278,"text":"Hyperglycemic effect of amino compounds structurally related to caproate in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperglycemic"],"disease_indices_start":[0],"disease_indices_end":[13],"drugs":["amino","caproate"],"drug_indices_start":[24,64],"drug_indices_end":[72,29]}
{"index":1279,"text":"The chronic feeding of small amounts (0.3-3% of diet weight) of certain amino derivatives of caproate resulted in hyperglycemia, an elevated glucose tolerance curve and, occasionally, glucosuria. Effective compounds included norleucine, norvaline, glutamate, epsilon-aminocaproate, methionine, and leucine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperglycemia","glucosuria"],"disease_indices_start":[196,266],"disease_indices_end":[209,276],"drugs":["amino","caproate","glucose","norleucine","norvaline","glutamate","epsilon-aminocaproate","methionine","leucine"],"drug_indices_start":[319,330,364,175,307,341,154,380,223],"drug_indices_end":[387,230,328,362,339,374,183,317,159]}
{"index":1280,"text":"Fatty liver induced by tetracycline in the rat. Dose-response relationships and effect of sex.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Fatty liver"],"disease_indices_start":[0],"disease_indices_end":[11],"drugs":["tetracycline"],"drug_indices_start":[23],"drug_indices_end":[35]}
{"index":1282,"text":"Fatal myeloencephalopathy due to intrathecal vincristine administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myeloencephalopathy"],"disease_indices_start":[6],"disease_indices_end":[25],"drugs":["vincristine"],"drug_indices_start":[45],"drug_indices_end":[56]}
{"index":1283,"text":"Vincristine was accidentally given intrathecally to a child with leukaemia, producing sensory and motor dysfunction followed by encephalopathy and death. Separate times for administering vincristine and intrathecal therapy is recommended.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["leukaemia","sensory and motor dysfunction","encephalopathy"],"disease_indices_start":[138,159,201],"disease_indices_end":[147,188,215],"drugs":["Vincristine","vincristine"],"drug_indices_start":[73,260],"drug_indices_end":[84,271]}
{"index":1284,"text":"Progesterone potentiation of bupivacaine arrhythmogenicity in pentobarbital-anesthetized rats and beating rat heart cell cultures.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Progesterone","bupivacaine","pentobarbital"],"drug_indices_start":[0,29,62],"drug_indices_end":[40,75,12]}
{"index":1286,"text":"Acute renal failure occurring during intravenous desferrioxamine therapy: recovery after haemodialysis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute renal failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["desferrioxamine"],"drug_indices_start":[49],"drug_indices_end":[64]}
{"index":1288,"text":"Neuroleptic-associated hyperprolactinemia. Can it be treated with bromocriptine?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperprolactinemia"],"disease_indices_start":[23],"disease_indices_end":[41],"drugs":["Neuroleptic","bromocriptine"],"drug_indices_start":[0,66],"drug_indices_end":[11,79]}
{"index":1290,"text":"Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsions"],"disease_indices_start":[24],"disease_indices_end":[35],"drugs":["Ethacrynic acid"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":1292,"text":"Pharmacology of gamma-aminobutyric acidA receptor complex after the in vivo administration of the anxioselective and anticonvulsant beta-carboline derivative abecarnil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["gamma-aminobutyric acid","beta-carboline","abecarnil"],"drug_indices_start":[16,132,158],"drug_indices_end":[167,146,39]}
{"index":1294,"text":"Recurrent myocardial infarction in a postpartum patient receiving bromocriptine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[10],"disease_indices_end":[31],"drugs":["bromocriptine"],"drug_indices_start":[66],"drug_indices_end":[79]}
{"index":1296,"text":"Asterixis induced by carbamazepine therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Asterixis"],"disease_indices_start":[0],"disease_indices_end":[9],"drugs":["carbamazepine"],"drug_indices_start":[21],"drug_indices_end":[34]}
{"index":1298,"text":"Pharmacodynamics of the hypotensive effect of levodopa in parkinsonian patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotensive","parkinsonian"],"disease_indices_start":[24,58],"disease_indices_end":[35,70],"drugs":["levodopa"],"drug_indices_start":[46],"drug_indices_end":[54]}
{"index":1300,"text":"Syndrome of inappropriate secretion of antidiuretic hormone after infusional vincristine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Syndrome of inappropriate secretion of antidiuretic hormone"],"disease_indices_start":[0],"disease_indices_end":[59],"drugs":["vincristine"],"drug_indices_start":[77],"drug_indices_end":[88]}
{"index":1302,"text":"Heart failure: to digitalise or not? The view against.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Heart failure"],"disease_indices_start":[0],"disease_indices_end":[13],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1304,"text":"Intravascular hemolysis and acute renal failure following intermittent rifampin therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolysis","acute renal failure"],"disease_indices_start":[14,28],"disease_indices_end":[23,47],"drugs":["rifampin"],"drug_indices_start":[71],"drug_indices_end":[79]}
{"index":1305,"text":"Renal failure is a rare complication associated with the use of rifampin. Intravascular hemolysis leading to acute renal failure following rifampin therapy is extremely rare. Two patients with leprosy who developed hemolysis and acute renal failure following rifampin are reported.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Renal failure","hemolysis","acute renal failure","leprosy","hemolysis","acute renal failure"],"disease_indices_start":[89,177,198,282,304,318],"disease_indices_end":[102,186,217,289,313,337],"drugs":["rifampin","rifampin","rifampin"],"drug_indices_start":[153,228,348],"drug_indices_end":[356,161,236]}
{"index":1306,"text":"Zidovudine-induced hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis"],"disease_indices_start":[19],"disease_indices_end":[28],"drugs":["Zidovudine"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1308,"text":"Thoracic hematomyelia secondary to coumadin anticoagulant therapy: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Thoracic hematomyelia"],"disease_indices_start":[0],"disease_indices_end":[21],"drugs":["coumadin"],"drug_indices_start":[35],"drug_indices_end":[43]}
{"index":1309,"text":"A case of thoracic hematomyelia secondary to anticoagulant therapy is presented. Clinical features, similar to 2 other previously reported cases, are discussed. A high index of suspicion may lead to a quick diagnostic procedure and successful decompressive surgery.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thoracic hematomyelia"],"disease_indices_start":[92],"disease_indices_end":[113],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1310,"text":"Mania associated with fluoxetine treatment in adolescents.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Mania"],"disease_indices_start":[0],"disease_indices_end":[5],"drugs":["fluoxetine"],"drug_indices_start":[22],"drug_indices_end":[32]}
{"index":1312,"text":"Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperlipoproteinemias"],"disease_indices_start":[43],"disease_indices_end":[64],"drugs":["Gemfibrozil","lovastatin"],"drug_indices_start":[0,12],"drug_indices_end":[11,22]}
{"index":1314,"text":"Hepatocellular carcinoma in Fanconi's anemia treated with androgen and corticosteroid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hepatocellular carcinoma","Fanconi's anemia"],"disease_indices_start":[0,28],"disease_indices_end":[24,44],"drugs":["androgen","corticosteroid"],"drug_indices_start":[58,71],"drug_indices_end":[66,85]}
{"index":1316,"text":"Chronic lesion of rostral ventrolateral medulla in spontaneously hypertensive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[65],"disease_indices_end":[77],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1318,"text":"Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: immunohistochemical study of neurons, astrocytes and serum-protein extravasation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Damage of substantia nigra pars reticulata","status epilepticus"],"disease_indices_start":[0,70],"disease_indices_end":[42,88],"drugs":["pilocarpine"],"drug_indices_start":[50],"drug_indices_end":[61]}
{"index":1320,"text":"Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[8],"disease_indices_end":[22],"drugs":["doxorubicin","N-(2-hydroxypropyl)methacrylamide"],"drug_indices_start":[26,59],"drug_indices_end":[92,37]}
{"index":1322,"text":"Topical 0.025% capsaicin in chronic post-herpetic neuralgia: efficacy, predictors of response and long-term course.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["post-herpetic neuralgia"],"disease_indices_start":[36],"disease_indices_end":[59],"drugs":["capsaicin"],"drug_indices_start":[15],"drug_indices_end":[24]}
{"index":1324,"text":"Serotonin reuptake inhibitors, paranoia, and the ventral basal ganglia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["paranoia"],"disease_indices_start":[31],"disease_indices_end":[39],"drugs":["Serotonin"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1326,"text":"Five cases of encephalitis during treatment of loiasis with diethylcarbamazine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["encephalitis","loiasis"],"disease_indices_start":[14,47],"disease_indices_end":[26,54],"drugs":["diethylcarbamazine"],"drug_indices_start":[60],"drug_indices_end":[78]}
{"index":1328,"text":"Delirium in an elderly woman possibly associated with administration of misoprostol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Delirium"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["misoprostol"],"drug_indices_start":[72],"drug_indices_end":[83]}
{"index":1330,"text":"Hepatocellular oxidant stress following intestinal ischemia-reperfusion injury.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ischemia","reperfusion injury"],"disease_indices_start":[51,60],"disease_indices_end":[59,78],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1332,"text":"Diphenhydramine prevents the haemodynamic changes of cimetidine in ICU patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Diphenhydramine","cimetidine"],"drug_indices_start":[0,53],"drug_indices_end":[63,15]}
{"index":1334,"text":"Acute renal failure due to rifampicin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute renal failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["rifampicin"],"drug_indices_start":[27],"drug_indices_end":[37]}
{"index":1336,"text":"Severe polyneuropathy and motor loss after intrathecal thiotepa combination chemotherapy: description of two cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["polyneuropathy"],"disease_indices_start":[7],"disease_indices_end":[21],"drugs":["thiotepa"],"drug_indices_start":[55],"drug_indices_end":[63]}
{"index":1338,"text":"Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cromakalim","pinacidil"],"drug_indices_start":[26,11],"drug_indices_end":[35,21]}
{"index":1340,"text":"Mefenamic acid-induced neutropenia and renal failure in elderly females with hypothyroidism.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neutropenia","renal failure","hypothyroidism"],"disease_indices_start":[23,39,77],"disease_indices_end":[34,52,91],"drugs":["Mefenamic acid"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":1342,"text":"Etiology of hypercalcemia in hemodialysis patients on calcium carbonate therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypercalcemia"],"disease_indices_start":[12],"disease_indices_end":[25],"drugs":["calcium carbonate"],"drug_indices_start":[54],"drug_indices_end":[71]}
{"index":1344,"text":"Methyldopa-induced hemolytic anemia in a 15 year old presenting as near-syncope.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolytic anemia","syncope"],"disease_indices_start":[19,72],"disease_indices_end":[35,79],"drugs":["Methyldopa"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1346,"text":"The long-term safety of danazol in women with hereditary angioedema.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hereditary angioedema"],"disease_indices_start":[46],"disease_indices_end":[67],"drugs":["danazol"],"drug_indices_start":[24],"drug_indices_end":[31]}
{"index":1348,"text":"Patient tolerance study of topical chlorhexidine diphosphanilate: a new topical agent for burns.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["burns"],"disease_indices_start":[90],"disease_indices_end":[95],"drugs":["chlorhexidine diphosphanilate"],"drug_indices_start":[35],"drug_indices_end":[64]}
{"index":1350,"text":"Dose-dependent neurotoxicity of high-dose busulfan in children: a clinical and pharmacological study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[15],"disease_indices_end":[28],"drugs":["busulfan"],"drug_indices_start":[42],"drug_indices_end":[50]}
{"index":1352,"text":"Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[49],"disease_indices_end":[60],"drugs":["Histamine","d-tubocurarine"],"drug_indices_start":[0,26],"drug_indices_end":[40,9]}
{"index":1354,"text":"Convulsant effect of lindane and regional brain concentration of GABA and dopamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lindane","GABA","dopamine"],"drug_indices_start":[65,74,21],"drug_indices_end":[82,28,69]}
{"index":1358,"text":"Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["status epilepticus"],"disease_indices_start":[69],"disease_indices_end":[87],"drugs":["MK-801","lithium","pilocarpine"],"drug_indices_start":[40,26,48],"drug_indices_end":[32,59,47]}
{"index":1360,"text":"Nifedipine induced bradycardia in a patient with autonomic neuropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia","autonomic neuropathy"],"disease_indices_start":[19,49],"disease_indices_end":[30,69],"drugs":["Nifedipine"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1362,"text":"The effect of haloperidol in cocaine and amphetamine intoxication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["haloperidol","cocaine","amphetamine"],"drug_indices_start":[41,29,14],"drug_indices_end":[25,36,52]}
{"index":1364,"text":"Autoradiographic evidence of estrogen binding sites in nuclei of diethylstilbesterol induced hamster renal carcinomas.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal carcinomas"],"disease_indices_start":[101],"disease_indices_end":[117],"drugs":["estrogen","diethylstilbesterol"],"drug_indices_start":[65,29],"drug_indices_end":[84,37]}
{"index":1366,"text":"Bradycardia due to biperiden.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Bradycardia"],"disease_indices_start":[0],"disease_indices_end":[11],"drugs":["biperiden"],"drug_indices_start":[19],"drug_indices_end":[28]}
{"index":1368,"text":"Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[11],"disease_indices_end":[22],"drugs":["labetalol","halothane","enflurane","isoflurane"],"drug_indices_start":[73,49,34,60],"drug_indices_end":[83,58,43,69]}
{"index":1370,"text":"Convulsion following intravenous fluorescein angiography.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Convulsion"],"disease_indices_start":[0],"disease_indices_end":[10],"drugs":["fluorescein"],"drug_indices_start":[33],"drug_indices_end":[44]}
{"index":1371,"text":"Tonic-clonic seizures followed intravenous fluorescein injection for fundus angiography in a 47-year-old male. Despite precautions this adverse reaction recurred on re-exposure to intravenous fluorescein.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Tonic-clonic seizures"],"disease_indices_start":[58],"disease_indices_end":[79],"drugs":["fluorescein","fluorescein"],"drug_indices_start":[250,101],"drug_indices_end":[112,261]}
{"index":1372,"text":"Pharmacology of ACC-9653 (phenytoin prodrug).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ACC-9653","phenytoin"],"drug_indices_start":[16,26],"drug_indices_end":[24,35]}
{"index":1374,"text":"Phenytoin induced fatal hepatic injury.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatic injury"],"disease_indices_start":[24],"disease_indices_end":[38],"drugs":["Phenytoin"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1376,"text":"Treatment of lethal pertussis vaccine reaction with histamine H1 antagonists.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pertussis vaccine","histamine"],"drug_indices_start":[20,52],"drug_indices_end":[61,37]}
{"index":1378,"text":"Support for adrenaline-hypertension hypothesis: 18 hour pressor effect after 6 hours adrenaline infusion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[23],"disease_indices_end":[35],"drugs":["adrenaline","adrenaline"],"drug_indices_start":[12,85],"drug_indices_end":[22,95]}
{"index":1380,"text":"Effect of alkylxanthines on gentamicin-induced acute renal failure in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute renal failure"],"disease_indices_start":[47],"disease_indices_end":[66],"drugs":["alkylxanthines","gentamicin"],"drug_indices_start":[10,28],"drug_indices_end":[24,38]}
{"index":1382,"text":"Adverse ocular reactions possibly associated with isotretinoin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["isotretinoin"],"drug_indices_start":[50],"drug_indices_end":[62]}
{"index":1384,"text":"Procaterol and terbutaline in bronchial asthma. A double-blind, placebo-controlled, cross-over study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bronchial asthma"],"disease_indices_start":[30],"disease_indices_end":[46],"drugs":["Procaterol","terbutaline"],"drug_indices_start":[0,15],"drug_indices_end":[10,26]}
{"index":1386,"text":"Subacute effects of propranolol and B 24\/76 on isoproterenol-induced rat heart hypertrophy in correlation with blood pressure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart hypertrophy"],"disease_indices_start":[73],"disease_indices_end":[90],"drugs":["propranolol","isoproterenol"],"drug_indices_start":[20,47],"drug_indices_end":[60,31]}
{"index":1388,"text":"Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["asthma"],"disease_indices_start":[93],"disease_indices_end":[99],"drugs":["oxitropium bromide","theophylline"],"drug_indices_start":[67,28],"drug_indices_end":[46,79]}
{"index":1390,"text":"Penicillin anaphylaxis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anaphylaxis"],"disease_indices_start":[11],"disease_indices_end":[22],"drugs":["Penicillin"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1392,"text":"Reversible valproic acid-induced dementia: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dementia"],"disease_indices_start":[33],"disease_indices_end":[41],"drugs":["valproic acid"],"drug_indices_start":[11],"drug_indices_end":[24]}
{"index":1394,"text":"Reversal of scopolamine-induced amnesia of passive avoidance by pre- and post-training naloxone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[32],"disease_indices_end":[39],"drugs":["scopolamine","naloxone"],"drug_indices_start":[12,87],"drug_indices_end":[95,23]}
{"index":1396,"text":"Electron microscopic investigations of the cyclophosphamide-induced lesions of the urinary bladder of the rat and their prevention by mesna.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["lesions of the urinary bladder"],"disease_indices_start":[68],"disease_indices_end":[98],"drugs":["cyclophosphamide","mesna"],"drug_indices_start":[43,134],"drug_indices_end":[59,139]}
{"index":1398,"text":"Increase in intragastric pressure during suxamethonium-induced muscle fasciculations in children: inhibition by alfentanil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscle fasciculations"],"disease_indices_start":[63],"disease_indices_end":[84],"drugs":["suxamethonium","alfentanil"],"drug_indices_start":[112,41],"drug_indices_end":[122,54]}
{"index":1400,"text":"Acute insulin treatment normalizes the resistance to the cardiotoxic effect of isoproterenol in streptozotocin diabetic rats. A morphometric study of isoproterenol induced myocardial fibrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxic","diabetic","fibrosis"],"disease_indices_start":[57,111,183],"disease_indices_end":[68,119,191],"drugs":["isoproterenol","streptozotocin","isoproterenol"],"drug_indices_start":[96,150,79],"drug_indices_end":[163,92,110]}
{"index":1402,"text":"Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[65],"disease_indices_end":[73],"drugs":["pilocarpine"],"drug_indices_start":[86],"drug_indices_end":[97]}
{"index":1404,"text":"Acute neurologic dysfunction after high-dose etoposide therapy for malignant glioma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute neurologic dysfunction","malignant glioma"],"disease_indices_start":[0,67],"disease_indices_end":[28,83],"drugs":["etoposide"],"drug_indices_start":[45],"drug_indices_end":[54]}
{"index":1406,"text":"Progressive bile duct injury after thiabendazole administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bile duct injury"],"disease_indices_start":[12],"disease_indices_end":[28],"drugs":["thiabendazole"],"drug_indices_start":[35],"drug_indices_end":[48]}
{"index":1408,"text":"Differential effects of 1,4-dihydropyridine calcium channel blockers: therapeutic implications.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["1,4-dihydropyridine","calcium channel blockers"],"drug_indices_start":[24,44],"drug_indices_end":[43,68]}
{"index":1410,"text":"The enhancement of aminonucleoside nephrosis by the co-administration of protamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrosis"],"disease_indices_start":[35],"disease_indices_end":[44],"drugs":["aminonucleoside"],"drug_indices_start":[19],"drug_indices_end":[34]}
{"index":1412,"text":"Theophylline neurotoxicity in pregnant rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[13],"disease_indices_end":[26],"drugs":["Theophylline"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":1414,"text":"Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperkalemia"],"disease_indices_start":[0],"disease_indices_end":[12],"drugs":["indomethacin","naproxen","fludrocortisone"],"drug_indices_start":[24,41,66],"drug_indices_end":[81,49,36]}
{"index":1416,"text":"Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypotension","cardiotoxicity"],"disease_indices_start":[0,34],"disease_indices_end":[11,48],"drugs":["cisplatin","5-fluorouracil"],"drug_indices_start":[91,77],"drug_indices_end":[105,86]}
{"index":1418,"text":"Fatal aplastic anemia in a patient treated with carbamazepine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aplastic anemia"],"disease_indices_start":[6],"disease_indices_end":[21],"drugs":["carbamazepine"],"drug_indices_start":[48],"drug_indices_end":[61]}
{"index":1420,"text":"Participation of a bulbospinal serotonergic pathway in the rat brain in clonidine-induced hypotension and bradycardia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","bradycardia"],"disease_indices_start":[90,106],"disease_indices_end":[101,117],"drugs":["clonidine"],"drug_indices_start":[72],"drug_indices_end":[81]}
{"index":1422,"text":"Hypertension in neuroblastoma induced by imipramine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypertension","neuroblastoma"],"disease_indices_start":[0,16],"disease_indices_end":[12,29],"drugs":["imipramine"],"drug_indices_start":[41],"drug_indices_end":[51]}
{"index":1424,"text":"Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["oral candidiasis","hoarseness"],"disease_indices_start":[38,58],"disease_indices_end":[54,68],"drugs":["beclomethasone dipropionate"],"drug_indices_start":[74],"drug_indices_end":[101]}
{"index":1426,"text":"Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[17],"disease_indices_end":[31],"drugs":["Cyclophosphamide"],"drug_indices_start":[0],"drug_indices_end":[16]}
{"index":1428,"text":"Studies of risk factors for aminoglycoside nephrotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[43],"disease_indices_end":[57],"drugs":["aminoglycoside"],"drug_indices_start":[28],"drug_indices_end":[42]}
{"index":1430,"text":"Flurothyl seizure thresholds in mice treated neonatally with a single injection of monosodium glutamate (MSG): evaluation of experimental parameters in flurothyl seizure testing.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure","seizure"],"disease_indices_start":[10,162],"disease_indices_end":[17,169],"drugs":["Flurothyl","monosodium glutamate","MSG","flurothyl"],"drug_indices_start":[0,105,83,152],"drug_indices_end":[9,161,108,103]}
{"index":1432,"text":"Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[18],"disease_indices_end":[26],"drugs":["pilocarpine","isoniazid","gamma-vinyl-GABA"],"drug_indices_start":[96,83,39],"drug_indices_end":[112,50,92]}
{"index":1434,"text":"Non-invasive detection of coronary artery disease by body surface electrocardiographic mapping after dipyridamole infusion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coronary artery disease"],"disease_indices_start":[26],"disease_indices_end":[49],"drugs":["dipyridamole"],"drug_indices_start":[101],"drug_indices_end":[113]}
{"index":1436,"text":"Bradycardia after high-dose intravenous methylprednisolone therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Bradycardia"],"disease_indices_start":[0],"disease_indices_end":[11],"drugs":["methylprednisolone"],"drug_indices_start":[40],"drug_indices_end":[58]}
{"index":1438,"text":"Two cases of downbeat nystagmus and oscillopsia associated with carbamazepine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["downbeat nystagmus","oscillopsia"],"disease_indices_start":[13,36],"disease_indices_end":[31,47],"drugs":["carbamazepine"],"drug_indices_start":[64],"drug_indices_end":[77]}
{"index":1440,"text":"Improvement by denopamine (TA-064) of pentobarbital-induced cardiac failure in the dog heart-lung preparation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac failure"],"disease_indices_start":[60],"disease_indices_end":[75],"drugs":["denopamine","TA-064","pentobarbital"],"drug_indices_start":[27,38,15],"drug_indices_end":[25,51,33]}
{"index":1442,"text":"Clonazepam monotherapy for epilepsy in childhood.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epilepsy"],"disease_indices_start":[27],"disease_indices_end":[35],"drugs":["Clonazepam"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1444,"text":"Postmarketing study of timolol-hydrochlorothiazide antihypertensive therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["timolol","hydrochlorothiazide"],"drug_indices_start":[31,23],"drug_indices_end":[50,30]}
{"index":1446,"text":"Salicylate nephropathy in the Gunn rat: potential role of prostaglandins.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[11],"disease_indices_end":[22],"drugs":["Salicylate","prostaglandins"],"drug_indices_start":[0,58],"drug_indices_end":[72,10]}
{"index":1448,"text":"Prophylactic lidocaine in the early phase of suspected myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[55],"disease_indices_end":[76],"drugs":["lidocaine"],"drug_indices_start":[13],"drug_indices_end":[22]}
{"index":1450,"text":"Evidence for a cholinergic role in haloperidol-induced catalepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[55],"disease_indices_end":[64],"drugs":["haloperidol"],"drug_indices_start":[35],"drug_indices_end":[46]}
{"index":1452,"text":"Cardiovascular dysfunction and hypersensitivity to sodium pentobarbital induced by chronic barium chloride ingestion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiovascular dysfunction","hypersensitivity"],"disease_indices_start":[0,31],"disease_indices_end":[26,47],"drugs":["sodium pentobarbital","barium chloride"],"drug_indices_start":[91,51],"drug_indices_end":[106,71]}
{"index":1454,"text":"Propranolol antagonism of phenylpropanolamine-induced hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[54],"disease_indices_end":[66],"drugs":["Propranolol","phenylpropanolamine"],"drug_indices_start":[0,26],"drug_indices_end":[11,45]}
{"index":1456,"text":"Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glomerular sclerosis","nephrosis"],"disease_indices_start":[23,73],"disease_indices_end":[43,82],"drugs":["aminonucleoside"],"drug_indices_start":[57],"drug_indices_end":[72]}
{"index":1458,"text":"Relationship between nicotine-induced seizures and hippocampal nicotinic receptors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[38],"disease_indices_end":[46],"drugs":["nicotine"],"drug_indices_start":[21],"drug_indices_end":[29]}
{"index":1460,"text":"The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity","nephrotoxicity"],"disease_indices_start":[51,141],"disease_indices_end":[65,155],"drugs":["p-aminophenol","acetaminophen","bis(p-nitrophenyl) phosphate","acetaminophen","p-aminophenol"],"drug_indices_start":[12,77,109,29,127],"drug_indices_end":[105,42,140,25,122]}
{"index":1462,"text":"Morphine-induced seizures in newborn infants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[17],"disease_indices_end":[25],"drugs":["Morphine"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":1464,"text":"Effect of vincristine sulfate on Pseudomonas infections in monkeys.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Pseudomonas infections"],"disease_indices_start":[33],"disease_indices_end":[55],"drugs":["vincristine sulfate"],"drug_indices_start":[10],"drug_indices_end":[29]}
{"index":1466,"text":"Central excitatory actions of flurazepam.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["flurazepam"],"drug_indices_start":[30],"drug_indices_end":[40]}
{"index":1470,"text":"Hormones and risk of breast cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast cancer"],"disease_indices_start":[21],"disease_indices_end":[34],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1472,"text":"Early infections in kidney, heart, and liver transplant recipients on cyclosporine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["infections"],"disease_indices_start":[6],"disease_indices_end":[16],"drugs":["cyclosporine"],"drug_indices_start":[70],"drug_indices_end":[82]}
{"index":1474,"text":"Structure-activity and dose-effect relationships of the antagonism of picrotoxin-induced seizures by cholecystokinin, fragments and analogues of cholecystokinin in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[89],"disease_indices_end":[97],"drugs":["picrotoxin","cholecystokinin","cholecystokinin"],"drug_indices_start":[145,101,70],"drug_indices_end":[80,116,160]}
{"index":1476,"text":"Vasopressin as a possible contributor to hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[41],"disease_indices_end":[53],"drugs":["Vasopressin"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1478,"text":"Toxic hepatitis induced by disulfiram in a non-alcoholic.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Toxic hepatitis"],"disease_indices_start":[0],"disease_indices_end":[15],"drugs":["disulfiram"],"drug_indices_start":[27],"drug_indices_end":[37]}
{"index":1479,"text":"A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram. The causative relationship was proven by challenge.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxic liver damage"],"disease_indices_start":[71],"disease_indices_end":[89],"drugs":["disulfiram"],"drug_indices_start":[141],"drug_indices_end":[151]}
{"index":1480,"text":"Atrial thrombosis involving the heart of F-344 rats ingesting quinacrine hydrochloride.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Atrial thrombosis"],"disease_indices_start":[0],"disease_indices_end":[17],"drugs":["quinacrine hydrochloride"],"drug_indices_start":[62],"drug_indices_end":[86]}
{"index":1482,"text":"Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Alternating sinus rhythm","sinoatrial block"],"disease_indices_start":[0,42],"disease_indices_end":[24,58],"drugs":["propranolol"],"drug_indices_start":[70],"drug_indices_end":[81]}
{"index":1484,"text":"Antitumor effect, cardiotoxicity, and nephrotoxicity of doxorubicin in the IgM solid immunocytoma-bearing LOU\/M\/WSL rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity","nephrotoxicity","immunocytoma"],"disease_indices_start":[18,38,85],"disease_indices_end":[32,52,97],"drugs":["doxorubicin"],"drug_indices_start":[56],"drug_indices_end":[67]}
{"index":1486,"text":"Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia","hypotension"],"disease_indices_start":[15,31],"disease_indices_end":[26,42],"drugs":["timolol","pilocarpine"],"drug_indices_start":[59,71],"drug_indices_end":[66,82]}
{"index":1488,"text":"Succinylcholine apnoea: attempted reversal with anticholinesterases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["apnoea"],"disease_indices_start":[16],"disease_indices_end":[22],"drugs":["Succinylcholine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":1490,"text":"Effect of doxorubicin on [omega-I-131]heptadecanoic acid myocardial scintigraphy and echocardiography in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["doxorubicin","[omega-I-131]heptadecanoic acid"],"drug_indices_start":[25,10],"drug_indices_end":[56,21]}
{"index":1492,"text":"Hemodynamics and myocardial metabolism under deliberate hypotension. An experimental study in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[56],"disease_indices_end":[67],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1494,"text":"Evidence for a selective brain noradrenergic involvement in the locomotor stimulant effects of amphetamine in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amphetamine"],"drug_indices_start":[95],"drug_indices_end":[106]}
{"index":1496,"text":"Accelerated junctional rhythms during oral verapamil therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Accelerated junctional rhythms"],"disease_indices_start":[0],"disease_indices_end":[30],"drugs":["verapamil"],"drug_indices_start":[43],"drug_indices_end":[52]}
{"index":1498,"text":"Treatment of ovarian cancer with a combination of cis-platinum, adriamycin, cyclophosphamide and hexamethylmelamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ovarian cancer"],"disease_indices_start":[13],"disease_indices_end":[27],"drugs":["cis-platinum","adriamycin","cyclophosphamide","hexamethylmelamine"],"drug_indices_start":[64,97,50,76],"drug_indices_end":[74,115,92,62]}
{"index":1500,"text":"Nontraumatic dissecting aneurysm of the basilar artery.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dissecting aneurysm"],"disease_indices_start":[13],"disease_indices_end":[32],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1501,"text":"A case of nontraumatic dissecting aneurysm of the basilar artery in association with hypertension, smoke, and oral contraceptives is reported in a young female patient with a locked-in syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dissecting aneurysm","hypertension","locked-in syndrome"],"disease_indices_start":[79,141,231],"disease_indices_end":[98,153,249],"drugs":["oral contraceptives"],"drug_indices_start":[166],"drug_indices_end":[185]}
{"index":1502,"text":"Propylthiouracil-induced hepatic damage.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatic damage"],"disease_indices_start":[25],"disease_indices_end":[39],"drugs":["Propylthiouracil"],"drug_indices_start":[0],"drug_indices_end":[16]}
{"index":1503,"text":"Two cases of propylthiouracil-induced liver damage have been observed. The first case is of an acute type of damage, proven by rechallenge; the second presents a clinical and histologic picture resembling chronic active hepatitis, with spontaneous remission.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["liver damage","chronic active hepatitis"],"disease_indices_start":[79,246],"disease_indices_end":[91,270],"drugs":["propylthiouracil"],"drug_indices_start":[54],"drug_indices_end":[70]}
{"index":1504,"text":"Studies on the bradycardia induced by bepridil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia"],"disease_indices_start":[15],"disease_indices_end":[26],"drugs":["bepridil"],"drug_indices_start":[38],"drug_indices_end":[46]}
{"index":1506,"text":"Hepatitis and renal tubular acidosis after anesthesia with methoxyflurane.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hepatitis","renal tubular acidosis"],"disease_indices_start":[0,14],"disease_indices_end":[9,36],"drugs":["methoxyflurane"],"drug_indices_start":[59],"drug_indices_end":[73]}
{"index":1508,"text":"Pituitary response to luteinizing hormone-releasing hormone during haloperidol-induced hyperprolactinemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperprolactinemia"],"disease_indices_start":[87],"disease_indices_end":[105],"drugs":["haloperidol"],"drug_indices_start":[67],"drug_indices_end":[78]}
{"index":1510,"text":"Antirifampicin antibodies in acute rifampicin-associated renal failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal failure"],"disease_indices_start":[57],"disease_indices_end":[70],"drugs":["rifampicin"],"drug_indices_start":[35],"drug_indices_end":[45]}
{"index":1512,"text":"Cardiovascular effects of hypotension induced by adenosine triphosphate and sodium nitroprusside on dogs with denervated hearts.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[26],"disease_indices_end":[37],"drugs":["adenosine triphosphate","sodium nitroprusside"],"drug_indices_start":[49,76],"drug_indices_end":[96,71]}
{"index":1514,"text":"Comparative study: Endografine (diatrizoate), Vasurix polyvidone (acetrizoate), Dimer-X (iocarmate) and Hexabrix (ioxaglate) in hysterosalpingography.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Endografine","diatrizoate","Vasurix polyvidone","acetrizoate","Dimer-X","iocarmate","Hexabrix","ioxaglate"],"drug_indices_start":[32,66,104,46,80,114,19,89],"drug_indices_end":[64,98,43,77,112,87,123,30]}
{"index":1516,"text":"Post-suxamethonium pains in Nigerian surgical patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pains"],"disease_indices_start":[19],"disease_indices_end":[24],"drugs":["suxamethonium"],"drug_indices_start":[5],"drug_indices_end":[18]}
{"index":1518,"text":"Medial changes in arterial spasm induced by L-norepinephrine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["spasm"],"disease_indices_start":[27],"disease_indices_end":[32],"drugs":["L-norepinephrine"],"drug_indices_start":[44],"drug_indices_end":[60]}
{"index":1520,"text":"Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amblyopia"],"disease_indices_start":[66],"disease_indices_end":[75],"drugs":["quinine"],"drug_indices_start":[58],"drug_indices_end":[65]}
{"index":1522,"text":"Suxamethonium-induced jaw stiffness and myalgia associated with atypical cholinesterase: case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["jaw stiffness","myalgia"],"disease_indices_start":[22,40],"disease_indices_end":[35,47],"drugs":["Suxamethonium"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":1524,"text":"Indomethacin-induced hyperkalemia in three patients with gouty arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperkalemia","gouty arthritis"],"disease_indices_start":[21,57],"disease_indices_end":[33,72],"drugs":["Indomethacin"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":1526,"text":"Etomidate: a foreshortened clinical trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Etomidate"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1528,"text":"Levodopa-induced dyskinesias are improved by fluoxetine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias"],"disease_indices_start":[17],"disease_indices_end":[28],"drugs":["Levodopa","fluoxetine"],"drug_indices_start":[0,45],"drug_indices_end":[8,55]}
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{"index":1534,"text":"Paclitaxel 3-hour infusion given alone and combined with carboplatin: preliminary results of dose-escalation trials.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Paclitaxel","carboplatin"],"drug_indices_start":[0,57],"drug_indices_end":[10,68]}
{"index":1536,"text":"The dose-dependent effect of misoprostol on indomethacin-induced renal dysfunction in well compensated cirrhosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal dysfunction","cirrhosis"],"disease_indices_start":[65,103],"disease_indices_end":[82,112],"drugs":["misoprostol","indomethacin"],"drug_indices_start":[44,29],"drug_indices_end":[40,56]}
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{"index":1544,"text":"Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nausea","vomiting"],"disease_indices_start":[112,123],"disease_indices_end":[118,131],"drugs":["granisetron","5-hydroxytryptamine","cisplatin"],"drug_indices_start":[48,153,23],"drug_indices_end":[162,34,67]}
{"index":1546,"text":"Adverse interaction between clonidine and verapamil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["clonidine","verapamil"],"drug_indices_start":[42,28],"drug_indices_end":[51,37]}
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{"index":1552,"text":"Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[19],"disease_indices_end":[27],"drugs":["Flumazenil","cocaine","diazepam"],"drug_indices_start":[0,55,47],"drug_indices_end":[10,54,63]}
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{"index":1556,"text":"Assessment of cardiomyocyte DNA synthesis during hypertrophy in adult mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertrophy"],"disease_indices_start":[49],"disease_indices_end":[60],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1558,"text":"Central cardiovascular effects of AVP and ANP in normotensive and spontaneously hypertensive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[80],"disease_indices_end":[92],"drugs":["AVP"],"drug_indices_start":[34],"drug_indices_end":[37]}
{"index":1560,"text":"Cutaneous exposure to warfarin-like anticoagulant causing an intracerebral hemorrhage: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["intracerebral hemorrhage"],"disease_indices_start":[61],"disease_indices_end":[85],"drugs":["warfarin"],"drug_indices_start":[22],"drug_indices_end":[30]}
{"index":1562,"text":"Pediatric heart transplantation without chronic maintenance steroids.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["steroids"],"drug_indices_start":[60],"drug_indices_end":[68]}
{"index":1564,"text":"Delirium during fluoxetine treatment. A case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Delirium"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["fluoxetine"],"drug_indices_start":[16],"drug_indices_end":[26]}
{"index":1566,"text":"Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Pulmonary edema","shock","lymphoma"],"disease_indices_start":[0,20,58],"disease_indices_end":[15,25,66],"drugs":["aracytine-C"],"drug_indices_start":[42],"drug_indices_end":[53]}
{"index":1568,"text":"Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac injury"],"disease_indices_start":[60],"disease_indices_end":[74],"drugs":["clentiazem","epinephrine"],"drug_indices_start":[40,21],"drug_indices_end":[51,31]}
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{"index":1571,"text":"We report a case of myocardial ischemia induced by cocaine. The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial ischemia","ischemia","coronary artery spasm"],"disease_indices_start":[57,101,130],"disease_indices_end":[76,109,151],"drugs":["cocaine","nitroglycerin","calcium"],"drug_indices_start":[88,186,168],"drug_indices_end":[193,181,95]}
{"index":1572,"text":"Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. A new model to test potential protectors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[20],"disease_indices_end":[34],"drugs":["Doxorubicin"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1574,"text":"Epinephrine dysrhythmogenicity is not enhanced by subtoxic bupivacaine in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Epinephrine","bupivacaine"],"drug_indices_start":[0,59],"drug_indices_end":[11,70]}
{"index":1576,"text":"Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Milk-alkali syndrome","hypoparathyroidism"],"disease_indices_start":[0,61],"disease_indices_end":[20,79],"drugs":["1,25(OH)2D"],"drug_indices_start":[32],"drug_indices_end":[42]}
{"index":1578,"text":"Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Encephalopathy","neuroleptic malignant syndrome","serotonin syndrome"],"disease_indices_start":[0,49,84],"disease_indices_end":[14,79,102],"drugs":["amitriptyline"],"drug_indices_start":[22],"drug_indices_end":[35]}
{"index":1580,"text":"Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tumor","hemorrhagic","tumor"],"disease_indices_start":[22,39,85],"disease_indices_end":[27,50,90],"drugs":["estrogen"],"drug_indices_start":[68],"drug_indices_end":[76]}
{"index":1582,"text":"Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bladder irritation"],"disease_indices_start":[102],"disease_indices_end":[120],"drugs":["nitric oxide"],"drug_indices_start":[33],"drug_indices_end":[45]}
{"index":1584,"text":"Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial ischemia","coronary stenosis"],"disease_indices_start":[70,111],"disease_indices_end":[89,128],"drugs":["calcium","CD-832","isoproterenol"],"drug_indices_start":[48,17,37],"drug_indices_end":[24,43,61]}
{"index":1586,"text":"The effect of recombinant human insulin-like growth factor-I on chronic puromycin aminonucleoside nephropathy in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[98],"disease_indices_end":[109],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[72],"drug_indices_end":[97]}
{"index":1588,"text":"Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[51],"disease_indices_end":[58],"drugs":["Nefiracetam","DM-9384","apomorphine"],"drug_indices_start":[0,13,31],"drug_indices_end":[42,11,20]}
{"index":1590,"text":"Human corticotropin-releasing hormone and thyrotropin-releasing hormone modulate the hypercapnic ventilatory response in humans.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypercapnic"],"disease_indices_start":[85],"disease_indices_end":[96],"drugs":["corticotropin","thyrotropin"],"drug_indices_start":[42,6],"drug_indices_end":[19,53]}
{"index":1592,"text":"Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: a placebo-controlled trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis B"],"disease_indices_start":[39],"disease_indices_end":[50],"drugs":["Lamivudine","hepatitis B surface antigen"],"drug_indices_start":[0,72],"drug_indices_end":[10,99]}
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{"index":1596,"text":"MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure","brain damage"],"disease_indices_start":[51,80],"disease_indices_end":[58,92],"drugs":["MK-801","pilocarpine"],"drug_indices_start":[0,16],"drug_indices_end":[27,6]}
{"index":1598,"text":"Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer: BRE-26, a phase II trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast cancer"],"disease_indices_start":[59],"disease_indices_end":[72],"drugs":["Paclitaxel","5-fluorouracil","folinic acid"],"drug_indices_start":[0,32,12],"drug_indices_end":[10,26,44]}
{"index":1600,"text":"Efficacy and proarrhythmia with the use of d,l-sotalol for sustained ventricular tachyarrhythmias.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proarrhythmia","ventricular tachyarrhythmias"],"disease_indices_start":[13,69],"disease_indices_end":[26,97],"drugs":["d,l-sotalol"],"drug_indices_start":[43],"drug_indices_end":[54]}
{"index":1602,"text":"Chronic hyperprolactinemia and changes in dopamine neurons.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperprolactinemia"],"disease_indices_start":[8],"disease_indices_end":[26],"drugs":["dopamine"],"drug_indices_start":[42],"drug_indices_end":[50]}
{"index":1604,"text":"Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["leukoencephalopathy"],"disease_indices_start":[43],"disease_indices_end":[62],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1606,"text":"Thrombotic complications in acute promyelocytic leukemia during all-trans-retinoic acid therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Thrombotic","acute promyelocytic leukemia"],"disease_indices_start":[0,28],"disease_indices_end":[10,56],"drugs":["all-trans-retinoic acid"],"drug_indices_start":[64],"drug_indices_end":[87]}
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{"index":1614,"text":"Hypertensive response during dobutamine stress echocardiography.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypertensive"],"disease_indices_start":[0],"disease_indices_end":[12],"drugs":["dobutamine"],"drug_indices_start":[29],"drug_indices_end":[39]}
{"index":1616,"text":"Continuously nebulized albuterol in severe exacerbations of asthma in adults: a case-controlled study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["asthma"],"disease_indices_start":[60],"disease_indices_end":[66],"drugs":["albuterol"],"drug_indices_start":[23],"drug_indices_end":[32]}
{"index":1618,"text":"Hyperosmolar nonketotic coma precipitated by lithium-induced nephrogenic diabetes insipidus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperosmolar nonketotic coma","nephrogenic diabetes insipidus"],"disease_indices_start":[0,61],"disease_indices_end":[28,91],"drugs":["lithium"],"drug_indices_start":[45],"drug_indices_end":[52]}
{"index":1620,"text":"Effects of the intracoronary infusion of cocaine on left ventricular systolic and diastolic function in humans.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cocaine"],"drug_indices_start":[41],"drug_indices_end":[48]}
{"index":1622,"text":"Heparin-induced thrombocytopenia, paradoxical thromboembolism, and other side effects of heparin therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia","thromboembolism"],"disease_indices_start":[16,46],"disease_indices_end":[32,61],"drugs":["Heparin","heparin"],"drug_indices_start":[0,89],"drug_indices_end":[96,7]}
{"index":1624,"text":"Nonopaque crystal deposition causing ureteric obstruction in patients with HIV undergoing indinavir therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ureteric obstruction"],"disease_indices_start":[37],"disease_indices_end":[57],"drugs":["indinavir"],"drug_indices_start":[90],"drug_indices_end":[99]}
{"index":1626,"text":"Ischemic colitis and sumatriptan use.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Ischemic colitis"],"disease_indices_start":[0],"disease_indices_end":[16],"drugs":["sumatriptan"],"drug_indices_start":[21],"drug_indices_end":[32]}
{"index":1630,"text":"Neuroleptic malignant syndrome and methylphenidate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Neuroleptic malignant syndrome"],"disease_indices_start":[0],"disease_indices_end":[30],"drugs":["methylphenidate"],"drug_indices_start":[35],"drug_indices_end":[50]}
{"index":1632,"text":"Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["17alpha-ethinylestradiol","bile salt"],"drug_indices_start":[24,87],"drug_indices_end":[48,96]}
{"index":1634,"text":"Glibenclamide-sensitive hypotension produced by helodermin assessed in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[24],"disease_indices_end":[35],"drugs":["Glibenclamide","helodermin"],"drug_indices_start":[0,48],"drug_indices_end":[58,13]}
{"index":1636,"text":"Long-term efficacy and adverse event of nifedipine sustained-release tablets for cyclosporin A-induced hypertension in patients with psoriasis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension","psoriasis"],"disease_indices_start":[103,133],"disease_indices_end":[115,142],"drugs":["nifedipine","cyclosporin A"],"drug_indices_start":[40,81],"drug_indices_end":[50,94]}
{"index":1638,"text":"Torsade de pointes ventricular tachycardia during low dose intermittent dobutamine treatment in a patient with dilated cardiomyopathy and congestive heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Torsade de pointes","ventricular tachycardia","dilated cardiomyopathy","congestive heart failure"],"disease_indices_start":[0,19,111,138],"disease_indices_end":[18,42,133,162],"drugs":["dobutamine"],"drug_indices_start":[72],"drug_indices_end":[82]}
{"index":1640,"text":"Positive skin tests in late reactions to radiographic contrast media.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["contrast media"],"drug_indices_start":[54],"drug_indices_end":[68]}
{"index":1642,"text":"Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperammonemic encephalopathy","hyperammonemic","encephalopathy","cancer","dehydration","infection"],"disease_indices_start":[18,33,51,143,159],"disease_indices_end":[32,47,57,154,168],"drugs":["5-fluorouracil"],"drug_indices_start":[103],"drug_indices_end":[117]}
{"index":1644,"text":"The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["quinine","4-aminopyridine","morphine"],"drug_indices_start":[27,116,15],"drug_indices_end":[42,124,22]}
{"index":1646,"text":"Nociceptin\/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["learning and memory impairment","learning","memory impairment"],"disease_indices_start":[41,54],"disease_indices_end":[49,71],"drugs":["Nociceptin","orphanin FQ","nocistatin","scopolamine"],"drug_indices_start":[0,27,83,11],"drug_indices_end":[94,10,37,22]}
{"index":1648,"text":"Meloxicam-induced liver toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["liver toxicity"],"disease_indices_start":[18],"disease_indices_end":[32],"drugs":["Meloxicam"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1650,"text":"Induction of apoptosis by remoxipride metabolites in HL60 and CD34+\/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aplastic anemia"],"disease_indices_start":[153],"disease_indices_end":[168],"drugs":["remoxipride","remoxipride"],"drug_indices_start":[26,133],"drug_indices_end":[144,37]}
{"index":1652,"text":"Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["1-(1,2-dihydro-2-acenaphthylenyl)piperazine"],"drug_indices_start":[60],"drug_indices_end":[103]}
{"index":1654,"text":"Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[78],"disease_indices_end":[87],"drugs":["nitric-oxide","haloperidol","NADPH"],"drug_indices_start":[26,58,106],"drug_indices_end":[69,38,111]}
{"index":1656,"text":"Prolonged left ventricular dysfunction occurs in patients with coronary artery disease after both dobutamine and exercise induced myocardial ischaemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["left ventricular dysfunction","coronary artery disease","myocardial ischaemia"],"disease_indices_start":[10,63,130],"disease_indices_end":[38,86,150],"drugs":["dobutamine"],"drug_indices_start":[98],"drug_indices_end":[108]}
{"index":1658,"text":"Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pulmonary hypertension","pulmonary hypertension"],"disease_indices_start":[16,109],"disease_indices_end":[38,131],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1660,"text":"Clinical aspects of heparin-induced thrombocytopenia and thrombosis and other side effects of heparin therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia","thrombosis"],"disease_indices_start":[36,57],"disease_indices_end":[52,67],"drugs":["heparin","heparin"],"drug_indices_start":[20,94],"drug_indices_end":[27,101]}
{"index":1662,"text":"A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["optic neuropathy"],"disease_indices_start":[20],"disease_indices_end":[36],"drugs":["tacrolimus","FK506"],"drug_indices_start":[65,53],"drug_indices_end":[70,63]}
{"index":1664,"text":"Hypercalcemia, arrhythmia, and mood stabilizers.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypercalcemia","arrhythmia"],"disease_indices_start":[0,15],"disease_indices_end":[13,25],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1666,"text":"Attenuation of nephrotoxicity by a novel lipid nanosphere (NS-718) incorporating amphotericin B.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[15],"disease_indices_end":[29],"drugs":["amphotericin B"],"drug_indices_start":[81],"drug_indices_end":[95]}
{"index":1668,"text":"Patterns of sulfadiazine acute nephrotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute nephrotoxicity"],"disease_indices_start":[25],"disease_indices_end":[45],"drugs":["sulfadiazine"],"drug_indices_start":[12],"drug_indices_end":[24]}
{"index":1670,"text":"Downbeat nystagmus associated with intravenous patient-controlled administration of morphine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Downbeat nystagmus"],"disease_indices_start":[0],"disease_indices_end":[18],"drugs":["morphine"],"drug_indices_start":[84],"drug_indices_end":[92]}
{"index":1672,"text":"Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[94],"disease_indices_end":[115],"drugs":["dronedarone","amiodarone"],"drug_indices_start":[42,58],"drug_indices_end":[68,53]}
{"index":1674,"text":"Phase 2 trial of liposomal doxorubicin (40 mg\/m(2)) in platinum\/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ovarian and fallopian tube cancers","ovarian","fallopian tube cancers","carcinoma of the peritoneum"],"disease_indices_start":[86,98,133],"disease_indices_end":[93,120,160],"drugs":["doxorubicin","platinum","paclitaxel"],"drug_indices_start":[64,27,55],"drug_indices_end":[74,38,63]}
{"index":1676,"text":"Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bipolar mania"],"disease_indices_start":[32],"disease_indices_end":[45],"drugs":["olanzapine","Olanzipine"],"drug_indices_start":[12,93],"drug_indices_end":[22,103]}
{"index":1678,"text":"The effect of pupil dilation with tropicamide on vision and driving simulator performance.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pupil dilation"],"disease_indices_start":[14],"disease_indices_end":[28],"drugs":["tropicamide"],"drug_indices_start":[34],"drug_indices_end":[45]}
{"index":1680,"text":"A case of isotretinoin embryopathy with bilateral anotia and Taussig-Bing malformation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["isotretinoin embryopathy","anotia","Taussig-Bing malformation"],"disease_indices_start":[10,50,61],"disease_indices_end":[34,56,86],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1681,"text":"We report a newborn infant with multiple congenital anomalies (anotia and Taussig-Bing malformation) due to exposure to isotretinoin within the first trimester. In this paper we aim to draw to the fact that caution is needed when prescribing vitamin A-containing drugs to women of childbearing years.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anotia","Taussig-Bing malformation"],"disease_indices_start":[151,162],"disease_indices_end":[157,187],"drugs":["isotretinoin","vitamin A"],"drug_indices_start":[208,330],"drug_indices_end":[339,220]}
{"index":1682,"text":"Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebo-controlled, double-blind crossover study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["stress incontinence"],"disease_indices_start":[73],"disease_indices_end":[92],"drugs":["methoxamine"],"drug_indices_start":[10],"drug_indices_end":[21]}
{"index":1684,"text":"Toleration of high doses of angiotensin-converting enzyme inhibitors in patients with chronic heart failure: results from the ATLAS trial. The Assessment of Treatment with Lisinopril and Survival.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart failure"],"disease_indices_start":[94],"disease_indices_end":[107],"drugs":["angiotensin-converting enzyme inhibitors","Lisinopril"],"drug_indices_start":[172,28],"drug_indices_end":[68,182]}
{"index":1686,"text":"Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxity","cocaine and ethanol abuse","cocaine","ethanol abuse"],"disease_indices_start":[35,70,82],"disease_indices_end":[47,77,95],"drugs":["Cocaine","ethanol","cocaethylene"],"drug_indices_start":[0,9,22],"drug_indices_end":[16,34,7]}
{"index":1688,"text":"Worsening of Parkinsonism after the use of veralipride for treatment of menopause: case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinsonism"],"disease_indices_start":[13],"disease_indices_end":[25],"drugs":["veralipride"],"drug_indices_start":[43],"drug_indices_end":[54]}
{"index":1689,"text":"We describe a female patient with stable Parkinson's disease who has shown a marked worsening of her motor functions following therapy of menopause related symptoms with veralipride, as well as the improvement of her symptoms back to baseline after discontinuation of the drug. We emphasize the anti-dopaminergic effect of veralipride.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[137],"disease_indices_end":[156],"drugs":["veralipride","veralipride"],"drug_indices_start":[266,419],"drug_indices_end":[277,430]}
{"index":1690,"text":"Viracept and irregular heartbeat warning.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["irregular heartbeat"],"disease_indices_start":[13],"disease_indices_end":[32],"drugs":["Viracept"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":1691,"text":"A group of doctors in Boston warn that the protease inhibitor Viracept may cause an irregular heart beat, known as bradycardia, in people with HIV. Bradycardia occurred in a 45-year-old male patient who was Viracept in combination with other anti-HIV drugs. The symptoms ceased after switching to another drug combination.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["irregular heart beat","bradycardia","Bradycardia"],"disease_indices_start":[126,157,190],"disease_indices_end":[146,168,201],"drugs":["Viracept","Viracept"],"drug_indices_start":[104,249],"drug_indices_end":[112,257]}
{"index":1692,"text":"Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Graves' disease"],"disease_indices_start":[93],"disease_indices_end":[108],"drugs":["propylthiouracil"],"drug_indices_start":[131],"drug_indices_end":[147]}
{"index":1694,"text":"Prevalence of heart disease in asymptomatic chronic cocaine users.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart disease"],"disease_indices_start":[14],"disease_indices_end":[27],"drugs":["cocaine"],"drug_indices_start":[52],"drug_indices_end":[59]}
{"index":1696,"text":"Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["isoproterenol"],"drug_indices_start":[55],"drug_indices_end":[68]}
{"index":1698,"text":"Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia","long-QT syndrome"],"disease_indices_start":[62,98],"disease_indices_end":[85,114],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1700,"text":"Prenatal cocaine exposure and cranial sonographic findings in preterm infants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["preterm infants"],"disease_indices_start":[62],"disease_indices_end":[77],"drugs":["cocaine"],"drug_indices_start":[9],"drug_indices_end":[16]}
{"index":1702,"text":"Thalidomide neuropathy in patients treated for metastatic prostate cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuropathy","prostate cancer"],"disease_indices_start":[12,58],"disease_indices_end":[22,73],"drugs":["Thalidomide"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1704,"text":"Overexpression of copper\/zinc-superoxide dismutase protects from kanamycin-induced hearing loss.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hearing loss"],"disease_indices_start":[83],"disease_indices_end":[95],"drugs":["copper","zinc","superoxide","kanamycin"],"drug_indices_start":[65,25,18,30],"drug_indices_end":[24,40,74,29]}
{"index":1706,"text":"Prednisone induces anxiety and glial cerebral changes in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anxiety"],"disease_indices_start":[19],"disease_indices_end":[26],"drugs":["Prednisone"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1708,"text":"Phase II study of carboplatin and liposomal doxorubicin in patients with recurrent squamous cell carcinoma of the cervix.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["squamous cell carcinoma of the cervix","squamous cell carcinoma","carcinoma of the cervix"],"disease_indices_start":[83,97],"disease_indices_end":[106,120],"drugs":["carboplatin","doxorubicin"],"drug_indices_start":[18,44],"drug_indices_end":[29,55]}
{"index":1710,"text":"Antimicrobial-induced mania (antibiomania): a review of spontaneous reports.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mania","antibiomania"],"disease_indices_start":[22,29],"disease_indices_end":[27,41],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1712,"text":"Levodopa-induced ocular dyskinesias in Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ocular dyskinesias","Parkinson's disease"],"disease_indices_start":[17,39],"disease_indices_end":[35,58],"drugs":["Levodopa"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":1714,"text":"A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dysmenorrhea"],"disease_indices_start":[81],"disease_indices_end":[93],"drugs":["glyceryl trinitrate","diclofenac"],"drug_indices_start":[16,41],"drug_indices_end":[51,35]}
{"index":1716,"text":"Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glomerular injury","nephrosis"],"disease_indices_start":[90,145],"disease_indices_end":[107,154],"drugs":["Temocapril","angiotensin","puromycin aminonucleoside"],"drug_indices_start":[0,119,39],"drug_indices_end":[144,10,50]}
{"index":1718,"text":"Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Pulmonary hypertension"],"disease_indices_start":[0],"disease_indices_end":[22],"drugs":["ibuprofen"],"drug_indices_start":[29],"drug_indices_end":[38]}
{"index":1720,"text":"Hyponatremia and syndrome of inappropriate anti-diuretic hormone reported with the use of Vincristine: an over-representation of Asians?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyponatremia","syndrome of inappropriate anti-diuretic hormone"],"disease_indices_start":[0,17],"disease_indices_end":[12,64],"drugs":["Vincristine"],"drug_indices_start":[90],"drug_indices_end":[101]}
{"index":1722,"text":"Delayed toxicity of cyclophosphamide on the bladder of DBA\/2 and C57BL\/6 female mouse.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[8],"disease_indices_end":[16],"drugs":["cyclophosphamide"],"drug_indices_start":[20],"drug_indices_end":[36]}
{"index":1724,"text":"High-dose 5-fluorouracil \/ folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer. A phase II study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gastric cancer"],"disease_indices_start":[114],"disease_indices_end":[128],"drugs":["5-fluorouracil","folinic acid","mitomycin C"],"drug_indices_start":[73,10,27],"drug_indices_end":[24,84,39]}
{"index":1726,"text":"Persistent sterile leukocyturia is associated with impaired renal function in human immunodeficiency virus type 1-infected children treated with indinavir.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["leukocyturia","impaired renal function","human immunodeficiency virus type 1-infected"],"disease_indices_start":[19,51,78],"disease_indices_end":[31,74,122],"drugs":["indinavir"],"drug_indices_start":[145],"drug_indices_end":[154]}
{"index":1728,"text":"Utility of troponin I in patients with cocaine-associated chest pain.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chest pain"],"disease_indices_start":[58],"disease_indices_end":[68],"drugs":["cocaine"],"drug_indices_start":[39],"drug_indices_end":[46]}
{"index":1730,"text":"Acute interstitial nephritis due to nicergoline (Sermion).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["interstitial nephritis"],"disease_indices_start":[6],"disease_indices_end":[28],"drugs":["nicergoline","Sermion"],"drug_indices_start":[49,36],"drug_indices_end":[56,47]}
{"index":1732,"text":"Neuroleptic malignant syndrome complicated by massive intestinal bleeding in a patient with chronic renal failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Neuroleptic malignant syndrome","bleeding","chronic renal failure"],"disease_indices_start":[0,65,92],"disease_indices_end":[30,73,113],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1736,"text":"Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiomyopathy"],"disease_indices_start":[62],"disease_indices_end":[76],"drugs":["Carvedilol","doxorubicin"],"drug_indices_start":[0,28],"drug_indices_end":[10,39]}
{"index":1738,"text":"Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperactivity","hyperactivity"],"disease_indices_start":[16,105],"disease_indices_end":[29,118],"drugs":["Cocaine","adenosine","amphetamine"],"drug_indices_start":[0,52,85],"drug_indices_end":[96,61,7]}
{"index":1740,"text":"Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradyarrhythmia","atrial fibrillation","myocardial infarction"],"disease_indices_start":[27,98,128],"disease_indices_end":[42,117,149],"drugs":["Amiodarone"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1742,"text":"Indomethacin-induced morphologic changes in the rat urinary bladder epithelium.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Indomethacin"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":1744,"text":"An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["prostate cancer"],"disease_indices_start":[77],"disease_indices_end":[92],"drugs":["thalidomide","androgen"],"drug_indices_start":[56,41],"drug_indices_end":[64,52]}
{"index":1746,"text":"Central nervous system toxicity following the administration of levobupivacaine for lumbar plexus block: A report of two cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Central nervous system toxicity"],"disease_indices_start":[0],"disease_indices_end":[31],"drugs":["levobupivacaine"],"drug_indices_start":[64],"drug_indices_end":[79]}
{"index":1748,"text":"Anaesthetic complications associated with myotonia congenita: case study and comparison with other myotonic disorders.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myotonia congenita","myotonic disorders"],"disease_indices_start":[42,99],"disease_indices_end":[60,117],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1750,"text":"Respiratory pattern in a rat model of epilepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epilepsy"],"disease_indices_start":[38],"disease_indices_end":[46],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1752,"text":"Increased serum soluble Fas in patients with acute liver failure due to paracetamol overdose.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute liver failure","overdose"],"disease_indices_start":[45,84],"disease_indices_end":[64,92],"drugs":["paracetamol"],"drug_indices_start":[72],"drug_indices_end":[83]}
{"index":1754,"text":"Bilateral subthalamic nucleus stimulation for Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[46],"disease_indices_end":[65],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1756,"text":"Ocular motility changes after subtenon carboplatin chemotherapy for retinoblastoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retinoblastoma"],"disease_indices_start":[68],"disease_indices_end":[82],"drugs":["carboplatin"],"drug_indices_start":[39],"drug_indices_end":[50]}
{"index":1758,"text":"Ethambutol and optic neuropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["optic neuropathy"],"disease_indices_start":[15],"disease_indices_end":[31],"drugs":["Ethambutol"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1760,"text":"Treatment of compensatory gustatory hyperhidrosis with topical glycopyrrolate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gustatory hyperhidrosis"],"disease_indices_start":[26],"disease_indices_end":[49],"drugs":["glycopyrrolate"],"drug_indices_start":[63],"drug_indices_end":[77]}
{"index":1762,"text":"Pharmacological characteristics and side effects of a new galenic formulation of propofol without soyabean oil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["propofol"],"drug_indices_start":[81],"drug_indices_end":[89]}
{"index":1764,"text":"Vinorelbine-related cardiac events: a meta-analysis of randomized clinical trials.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Vinorelbine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1766,"text":"MRI findings of hypoxic cortical laminar necrosis in a child with hemolytic anemia crisis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["necrosis","hemolytic anemia"],"disease_indices_start":[41,66],"disease_indices_end":[49,82],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1768,"text":"The natural history of Vigabatrin associated visual field defects in patients electing to continue their medication.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["visual field defects"],"disease_indices_start":[45],"disease_indices_end":[65],"drugs":["Vigabatrin"],"drug_indices_start":[23],"drug_indices_end":[33]}
{"index":1770,"text":"Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dermatitis","facial inflammatory dermatoses"],"disease_indices_start":[25,56],"disease_indices_end":[35,86],"drugs":["tacrolimus"],"drug_indices_start":[92],"drug_indices_end":[102]}
{"index":1772,"text":"Structural abnormalities in the brains of human subjects who use methamphetamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["methamphetamine"],"drug_indices_start":[65],"drug_indices_end":[80]}
{"index":1774,"text":"Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["amiodarone"],"drug_indices_start":[54],"drug_indices_end":[64]}
{"index":1776,"text":"Safety and compliance with once-daily niacin extended-release\/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["niacin extended-release\/lovastatin"],"drug_indices_start":[38],"drug_indices_end":[72]}
{"index":1778,"text":"Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial injury"],"disease_indices_start":[61],"disease_indices_end":[78],"drugs":["Terminalia chebula","isoproterenol"],"drug_indices_start":[90,21],"drug_indices_end":[103,39]}
{"index":1780,"text":"A case of postoperative anxiety due to low dose droperidol used with patient-controlled analgesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anxiety"],"disease_indices_start":[24],"disease_indices_end":[31],"drugs":["droperidol"],"drug_indices_start":[48],"drug_indices_end":[58]}
{"index":1782,"text":"Accurate patient history contributes to differentiating diabetes insipidus: a case study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetes insipidus"],"disease_indices_start":[56],"disease_indices_end":[74],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1784,"text":"Factors contributing to ribavirin-induced anemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anemia"],"disease_indices_start":[42],"disease_indices_end":[48],"drugs":["ribavirin"],"drug_indices_start":[24],"drug_indices_end":[33]}
{"index":1786,"text":"Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mitochondrial injury"],"disease_indices_start":[73],"disease_indices_end":[93],"drugs":["adriamycin"],"drug_indices_start":[46],"drug_indices_end":[56]}
{"index":1788,"text":"Sotalol-induced coronary spasm in a patient with dilated cardiomyopathy associated with sustained ventricular tachycardia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coronary spasm","dilated cardiomyopathy","ventricular tachycardia"],"disease_indices_start":[16,49,98],"disease_indices_end":[30,71,121],"drugs":["Sotalol"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":1790,"text":"Effects of the antidepressant trazodone, a 5-HT 2A\/2C receptor antagonist, on dopamine-dependent behaviors in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["trazodone","5-HT","dopamine"],"drug_indices_start":[78,43,30],"drug_indices_end":[47,86,39]}
{"index":1792,"text":"Swallowing abnormalities and dyskinesia in Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Swallowing abnormalities","dyskinesia","Parkinson's disease"],"disease_indices_start":[0,29,43],"disease_indices_end":[24,39,62],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1794,"text":"Inhibition of nuclear factor-kappaB activation attenuates tubulointerstitial nephritis induced by gentamicin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tubulointerstitial nephritis"],"disease_indices_start":[58],"disease_indices_end":[86],"drugs":["gentamicin"],"drug_indices_start":[98],"drug_indices_end":[108]}
{"index":1796,"text":"Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["schizophrenia"],"disease_indices_start":[36],"disease_indices_end":[49],"drugs":["Glucose","glucose"],"drug_indices_start":[0,127],"drug_indices_end":[134,7]}
{"index":1798,"text":"Focal cerebral ischemia in rats: effect of phenylephrine-induced hypertension during reperfusion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cerebral ischemia","hypertension"],"disease_indices_start":[6,65],"disease_indices_end":[23,77],"drugs":["phenylephrine"],"drug_indices_start":[43],"drug_indices_end":[56]}
{"index":1800,"text":"People aged over 75 in atrial fibrillation on warfarin: the rate of major hemorrhage and stroke in more than 500 patient-years of follow-up.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrial fibrillation","hemorrhage","stroke"],"disease_indices_start":[23,74,89],"disease_indices_end":[42,84,95],"drugs":["warfarin"],"drug_indices_start":[46],"drug_indices_end":[54]}
{"index":1802,"text":"Safety of celecoxib in patients with adverse skin reactions to acetaminophen (paracetamol) and nimesulide associated or not with common non-steroidal anti-inflammatory drugs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["skin reactions"],"disease_indices_start":[45],"disease_indices_end":[59],"drugs":["celecoxib","acetaminophen","paracetamol","nimesulide"],"drug_indices_start":[10,95,78,63],"drug_indices_end":[89,19,76,105]}
{"index":1804,"text":"Case-control study of regular analgesic and nonsteroidal anti-inflammatory use and end-stage renal disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["end-stage renal disease"],"disease_indices_start":[83],"disease_indices_end":[106],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1806,"text":"Two cases of amisulpride overdose: a cause for prolonged QT syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["overdose","prolonged QT syndrome"],"disease_indices_start":[25,47],"disease_indices_end":[33,68],"drugs":["amisulpride"],"drug_indices_start":[13],"drug_indices_end":[24]}
{"index":1807,"text":"Two cases of deliberate self-poisoning with 5 g and 3.6 g of amisulpride, respectively, are reported. In both cases, QT prolongation and hypocalcaemia were noted. The QT prolongation appeared to respond to administration of i.v. calcium gluconate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["poisoning","QT prolongation","hypocalcaemia","QT prolongation"],"disease_indices_start":[99,187,207,237],"disease_indices_end":[108,202,220,252],"drugs":["amisulpride","calcium gluconate"],"drug_indices_start":[299,131],"drug_indices_end":[316,142]}
{"index":1808,"text":"Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epileptic"],"disease_indices_start":[82],"disease_indices_end":[91],"drugs":["cycloheximide"],"drug_indices_start":[110],"drug_indices_end":[123]}
{"index":1810,"text":"Nicotine antagonizes caffeine- but not pentylenetetrazole-induced anxiogenic effect in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Nicotine","caffeine","pentylenetetrazole"],"drug_indices_start":[0,21,39],"drug_indices_end":[8,57,29]}
{"index":1814,"text":"Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Drug-induced liver injury"],"disease_indices_start":[0],"disease_indices_end":[25],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1816,"text":"Morphological evaluation of the effect of d-ribose on adriamycin-evoked cardiotoxicity in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[72],"disease_indices_end":[86],"drugs":["d-ribose","adriamycin"],"drug_indices_start":[42,54],"drug_indices_end":[64,50]}
{"index":1817,"text":"The influence of d-ribose on adriamycin-induced myocardiopathy in rats was studied. Adriamycin in the cumulative dose of 25 mg\/kg evoked fully developed cardiac toxicity. D-ribose in the multiple doses of 200 mg\/kg did not influence ADR cardiotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardiopathy","cardiac toxicity","cardiotoxicity"],"disease_indices_start":[144,249,333],"disease_indices_end":[158,265,347],"drugs":["d-ribose","adriamycin","Adriamycin","D-ribose","ADR"],"drug_indices_start":[329,267,113,180,125],"drug_indices_end":[135,332,275,121,190]}
{"index":1818,"text":"In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[96],"disease_indices_end":[110],"drugs":["vancomycin","erdosteine"],"drug_indices_start":[77,126],"drug_indices_end":[136,87]}
{"index":1820,"text":"Does domperidone potentiate mirtazapine-associated restless legs syndrome?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["restless legs syndrome"],"disease_indices_start":[51],"disease_indices_end":[73],"drugs":["domperidone","mirtazapine"],"drug_indices_start":[28,5],"drug_indices_end":[16,39]}
{"index":1822,"text":"Antiandrogenic therapy can cause coronary arterial disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coronary arterial disease"],"disease_indices_start":[33],"disease_indices_end":[58],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1824,"text":"5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[15],"disease_indices_end":[29],"drugs":["5-Fluorouracil","alpha-fluoro-beta-alanine"],"drug_indices_start":[0,41],"drug_indices_end":[66,14]}
{"index":1826,"text":"The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[128],"disease_indices_end":[142],"drugs":["monoHER","doxorubicin","doxorubicin"],"drug_indices_start":[43,108,55],"drug_indices_end":[50,66,119]}
{"index":1828,"text":"Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrial fibrillation and flutter","atrial fibrillation","atrial"],"disease_indices_start":[74],"disease_indices_end":[80,93,105],"drugs":["bepridil"],"drug_indices_start":[46],"drug_indices_end":[54]}
{"index":1830,"text":"Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac hypertrophy"],"disease_indices_start":[31],"disease_indices_end":[50],"drugs":["isoproterenol"],"drug_indices_start":[9],"drug_indices_end":[22]}
{"index":1832,"text":"Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["long QT syndrome"],"disease_indices_start":[13],"disease_indices_end":[29],"drugs":["methadone"],"drug_indices_start":[64],"drug_indices_end":[73]}
{"index":1834,"text":"Mechanisms of hypertension induced by nitric oxide (NO) deficiency: focus on venous function.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[14],"disease_indices_end":[26],"drugs":["nitric oxide","NO"],"drug_indices_start":[52,38],"drug_indices_end":[50,54]}
{"index":1836,"text":"Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["extrapyramidal syndrome","schizophrenic"],"disease_indices_start":[61,96],"disease_indices_end":[84,109],"drugs":["chlorpromazine"],"drug_indices_start":[38],"drug_indices_end":[52]}
{"index":1838,"text":"Physical training decreases susceptibility to subsequent pilocarpine-induced seizures in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[77],"disease_indices_end":[85],"drugs":["pilocarpine"],"drug_indices_start":[57],"drug_indices_end":[68]}
{"index":1840,"text":"Tonic dopaminergic stimulation impairs associative learning in healthy subjects.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["impairs associative learning"],"disease_indices_start":[31],"disease_indices_end":[59],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1842,"text":"Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vasculitis","polyarteritis nodosa"],"disease_indices_start":[20,58],"disease_indices_end":[30,78],"drugs":["Minocycline"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1844,"text":"Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis B","hepatitis B"],"disease_indices_start":[14,84],"disease_indices_end":[25,95],"drugs":["lamivudine"],"drug_indices_start":[56],"drug_indices_end":[66]}
{"index":1846,"text":"Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[64],"disease_indices_end":[72],"drugs":["eslicarbazepine acetate","BIA 2-093","picrotoxin"],"drug_indices_start":[25,50,102],"drug_indices_end":[48,59,112]}
{"index":1848,"text":"Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute renal failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["anthraquinones"],"drug_indices_start":[82],"drug_indices_end":[96]}
{"index":1850,"text":"Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[92],"disease_indices_end":[103],"drugs":["Chloroacetaldehyde","sulfhydryl","thiol","ifosfamide"],"drug_indices_start":[0,24,65,81],"drug_indices_end":[18,91,34,70]}
{"index":1852,"text":"Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["status epilepticus"],"disease_indices_start":[116],"disease_indices_end":[134],"drugs":["pilocarpine"],"drug_indices_start":[96],"drug_indices_end":[107]}
{"index":1854,"text":"A prospective, open-label trial of galantamine in autistic disorder.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["autistic disorder"],"disease_indices_start":[50],"disease_indices_end":[67],"drugs":["galantamine"],"drug_indices_start":[35],"drug_indices_end":[46]}
{"index":1856,"text":"Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["schizophrenia"],"disease_indices_start":[90],"disease_indices_end":[103],"drugs":["olanzapine","risperidone"],"drug_indices_start":[25,43],"drug_indices_end":[35,54]}
{"index":1858,"text":"Early paracentral visual field loss in patients taking hydroxychloroquine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["visual field loss"],"disease_indices_start":[18],"disease_indices_end":[35],"drugs":["hydroxychloroquine"],"drug_indices_start":[55],"drug_indices_end":[73]}
{"index":1860,"text":"Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrioventricular block"],"disease_indices_start":[15],"disease_indices_end":[37],"drugs":["epirubicin","paclitaxel"],"drug_indices_start":[86,71],"drug_indices_end":[96,81]}
{"index":1862,"text":"Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["COX-2 inhibitors"],"drug_indices_start":[22],"drug_indices_end":[38]}
{"index":1864,"text":"Quinine-induced arrhythmia in a patient with severe malaria.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["arrhythmia","severe malaria"],"disease_indices_start":[16,45],"disease_indices_end":[26,59],"drugs":["Quinine"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":1866,"text":"Penicillamine-related lichenoid dermatitis and utility of zinc acetate in a Wilson disease patient with hepatic presentation, anxiety and SPECT abnormalities.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["lichenoid dermatitis","Wilson disease","anxiety"],"disease_indices_start":[22,76,126],"disease_indices_end":[42,90,133],"drugs":["Penicillamine","zinc acetate"],"drug_indices_start":[0,58],"drug_indices_end":[13,70]}
{"index":1868,"text":"A dramatic drop in blood pressure following prehospital GTN administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["drop in blood pressure"],"disease_indices_start":[11],"disease_indices_end":[33],"drugs":["GTN"],"drug_indices_start":[56],"drug_indices_end":[59]}
{"index":1870,"text":"Acute encephalopathy and cerebral vasospasm after multiagent chemotherapy including PEG-asparaginase and intrathecal cytarabine for the treatment of acute lymphoblastic leukemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute encephalopathy","cerebral vasospasm","acute lymphoblastic leukemia"],"disease_indices_start":[0,25,149],"disease_indices_end":[20,43,177],"drugs":["PEG-asparaginase","cytarabine"],"drug_indices_start":[84,117],"drug_indices_end":[100,127]}
{"index":1872,"text":"Comparison of valsartan\/hydrochlorothiazide combination therapy at doses up to 320\/25 mg versus monotherapy: a double-blind, placebo-controlled study followed by long-term combination therapy in hypertensive adults.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[195],"disease_indices_end":[207],"drugs":["valsartan","hydrochlorothiazide"],"drug_indices_start":[24,14],"drug_indices_end":[43,23]}
{"index":1874,"text":"Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive impairment"],"disease_indices_start":[114],"disease_indices_end":[134],"drugs":["Succimer","lead","lead"],"drug_indices_start":[0,153,75],"drug_indices_end":[8,157,79]}
{"index":1876,"text":"Caffeine challenge test in panic disorder and depression with panic attacks.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["panic disorder","depression","panic attacks"],"disease_indices_start":[27,46,62],"disease_indices_end":[41,56,75],"drugs":["Caffeine"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":1878,"text":"Mitral annuloplasty as a ventricular restoration method for the failing left ventricle: a pilot study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["failing left ventricle"],"disease_indices_start":[64],"disease_indices_end":[86],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1880,"text":"Piperacillin\/tazobactam-induced seizure rapidly reversed by high flux hemodialysis in a patient on peritoneal dialysis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizure"],"disease_indices_start":[32],"disease_indices_end":[39],"drugs":["Piperacillin\/tazobactam"],"drug_indices_start":[0],"drug_indices_end":[23]}
{"index":1882,"text":"Frequency of transient ipsilateral vocal cord paralysis in patients undergoing carotid endarterectomy under local anesthesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vocal cord paralysis"],"disease_indices_start":[35],"disease_indices_end":[55],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1884,"text":"Neuroprotective effects of melatonin upon the offspring cerebellar cortex in the rat model of BCNU-induced cortical dysplasia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cortical dysplasia"],"disease_indices_start":[107],"disease_indices_end":[125],"drugs":["melatonin","BCNU"],"drug_indices_start":[27,94],"drug_indices_end":[98,36]}
{"index":1886,"text":"Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Myo-inositol-1-phosphate","MIP"],"drug_indices_start":[0,26],"drug_indices_end":[24,29]}
{"index":1888,"text":"Non-steroidal anti-inflammatory drugs-associated acute interstitial nephritis with granular tubular basement membrane deposits.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["interstitial nephritis"],"disease_indices_start":[55],"disease_indices_end":[77],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1890,"text":"Rifampicin-associated segmental necrotizing glomerulonephritis in staphylococcal endocarditis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glomerulonephritis","staphylococcal endocarditis","staphylococcal","endocarditis"],"disease_indices_start":[44,66,81],"disease_indices_end":[62,80,93],"drugs":["Rifampicin"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1892,"text":"Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["chronic hepatitis B virus infection"],"disease_indices_start":[73],"disease_indices_end":[108],"drugs":["lamivudine"],"drug_indices_start":[30],"drug_indices_end":[40]}
{"index":1894,"text":"Branch retinal vein occlusion and fluoxetine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retinal vein occlusion"],"disease_indices_start":[7],"disease_indices_end":[29],"drugs":["fluoxetine"],"drug_indices_start":[34],"drug_indices_end":[44]}
{"index":1895,"text":"A case of branch retinal vein occlusion associated with fluoxetine-induced secondary hypertension is described. Although an infrequent complication of selective serotonin reuptake inhibitor therapy, it is important that ophthalmologists are aware that these agents can cause hypertension because this class of drugs is widely prescribed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["retinal vein occlusion","hypertension","hypertension"],"disease_indices_start":[63,131,321],"disease_indices_end":[85,143,333],"drugs":["fluoxetine","serotonin"],"drug_indices_start":[102,207],"drug_indices_end":[112,216]}
{"index":1896,"text":"The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain","pain"],"disease_indices_start":[118,137],"disease_indices_end":[122,141],"drugs":["bupivacaine","lidocaine","prostaglandin E2"],"drug_indices_start":[57,28,44],"drug_indices_end":[73,53,39]}
{"index":1898,"text":"p75NTR expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide-induced cystitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cystitis"],"disease_indices_start":[103],"disease_indices_end":[111],"drugs":["cyclophosphamide"],"drug_indices_start":[78],"drug_indices_end":[94]}
{"index":1900,"text":"Azathioprine-induced suicidal erythrocyte death.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Azathioprine"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":1904,"text":"Spectrum of adverse events after generic HAART in southern Indian HIV-infected patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["HIV-infected"],"disease_indices_start":[66],"disease_indices_end":[78],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":1906,"text":"Thalidomide and sensory neurotoxicity: a neurophysiological study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sensory neurotoxicity"],"disease_indices_start":[16],"disease_indices_end":[37],"drugs":["Thalidomide"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1908,"text":"Amiodarone-related pulmonary mass and unique membranous glomerulonephritis in a patient with valvular heart disease: Diagnostic pitfall and new findings.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pulmonary mass","membranous glomerulonephritis","valvular heart disease"],"disease_indices_start":[19,45,93],"disease_indices_end":[33,74,115],"drugs":["Amiodarone"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":1910,"text":"Risk of coronary artery disease associated with initial sulphonylurea treatment of patients with type 2 diabetes: a matched case-control study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coronary artery disease","type 2 diabetes"],"disease_indices_start":[8,97],"disease_indices_end":[31,112],"drugs":["sulphonylurea"],"drug_indices_start":[56],"drug_indices_end":[69]}
{"index":1912,"text":"Reduced progression of adriamycin nephropathy in spontaneously hypertensive rats treated by losartan.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy","hypertensive"],"disease_indices_start":[34,63],"disease_indices_end":[45,75],"drugs":["adriamycin","losartan"],"drug_indices_start":[92,23],"drug_indices_end":[33,100]}
{"index":1914,"text":"The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year follow-up of 1188 consecutive patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tranexamic acid"],"drug_indices_start":[27],"drug_indices_end":[42]}
{"index":1916,"text":"The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac arrhythmias"],"disease_indices_start":[85],"disease_indices_end":[104],"drugs":["propranolol"],"drug_indices_start":[52],"drug_indices_end":[63]}
{"index":1918,"text":"Topotecan in combination with radiotherapy in unresectable glioblastoma: a phase 2 study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glioblastoma"],"disease_indices_start":[59],"disease_indices_end":[71],"drugs":["Topotecan"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":1920,"text":"Long-term lithium therapy leading to hyperparathyroidism: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperparathyroidism"],"disease_indices_start":[37],"disease_indices_end":[56],"drugs":["lithium"],"drug_indices_start":[10],"drug_indices_end":[17]}
{"index":1924,"text":"Nonalcoholic fatty liver disease during valproate therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Nonalcoholic fatty liver disease"],"disease_indices_start":[0],"disease_indices_end":[32],"drugs":["valproate"],"drug_indices_start":[40],"drug_indices_end":[49]}
{"index":1926,"text":"Carbimazole induced ANCA positive vasculitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ANCA positive vasculitis"],"disease_indices_start":[20],"disease_indices_end":[44],"drugs":["Carbimazole"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":1928,"text":"Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Aspirin"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":1930,"text":"Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia"],"disease_indices_start":[113],"disease_indices_end":[129],"drugs":["argatroban","heparin"],"drug_indices_start":[97,75],"drug_indices_end":[104,85]}
{"index":1932,"text":"Rhabdomyolysis and brain ischemic stroke in a heroin-dependent male under methadone maintenance therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Rhabdomyolysis","ischemic stroke"],"disease_indices_start":[0,25],"disease_indices_end":[14,40],"drugs":["heroin","methadone"],"drug_indices_start":[74,46],"drug_indices_end":[83,52]}
{"index":1934,"text":"Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias"],"disease_indices_start":[79],"disease_indices_end":[90],"drugs":["6-hydroxydopamine"],"drug_indices_start":[27],"drug_indices_end":[44]}
{"index":1936,"text":"Animal model of mania induced by ouabain: Evidence of oxidative stress in submitochondrial particles of the rat brain.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mania"],"disease_indices_start":[16],"disease_indices_end":[21],"drugs":["ouabain"],"drug_indices_start":[33],"drug_indices_end":[40]}
{"index":1938,"text":"Intraoperative dialysis during liver transplantation with citrate dialysate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["citrate"],"drug_indices_start":[58],"drug_indices_end":[65]}
{"index":1940,"text":"Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Delirium"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["flecainide","paroxetine"],"drug_indices_start":[33,119],"drug_indices_end":[129,43]}
{"index":1942,"text":"Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["NSCLC"],"disease_indices_start":[58],"disease_indices_end":[63],"drugs":["everolimus","RAD001"],"drug_indices_start":[24,12],"drug_indices_end":[22,30]}
{"index":1944,"text":"Posttransplant anemia: the role of sirolimus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anemia"],"disease_indices_start":[15],"disease_indices_end":[21],"drugs":["sirolimus"],"drug_indices_start":[35],"drug_indices_end":[44]}
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{"index":1948,"text":"Late fulminant posterior reversible encephalopathy syndrome after liver transplant.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["posterior reversible encephalopathy syndrome"],"disease_indices_start":[15],"disease_indices_end":[59],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
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{"index":1952,"text":"Binasal visual field defects are not specific to vigabatrin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Binasal visual field defects"],"disease_indices_start":[0],"disease_indices_end":[28],"drugs":["vigabatrin"],"drug_indices_start":[49],"drug_indices_end":[59]}
{"index":1954,"text":"Smoking of crack cocaine as a risk factor for HIV infection among people who use injection drugs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["HIV infection"],"disease_indices_start":[46],"disease_indices_end":[59],"drugs":["crack cocaine"],"drug_indices_start":[11],"drug_indices_end":[24]}
{"index":1956,"text":"Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["memory deficits"],"disease_indices_start":[24],"disease_indices_end":[39],"drugs":["Fluoxetine","5-fluorouracil"],"drug_indices_start":[0,73],"drug_indices_end":[10,87]}
{"index":1958,"text":"Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatomegaly"],"disease_indices_start":[115],"disease_indices_end":[127],"drugs":["phenobarbital"],"drug_indices_start":[134],"drug_indices_end":[147]}
{"index":1960,"text":"Decreased Expression of Na\/K-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Nephropathy"],"disease_indices_start":[84],"disease_indices_end":[95],"drugs":["Na","K","Gentamicin"],"drug_indices_start":[24,65,27],"drug_indices_end":[26,75,28]}
{"index":1962,"text":"Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["HIV disease"],"disease_indices_start":[45],"disease_indices_end":[56],"drugs":["alcohol"],"drug_indices_start":[28],"drug_indices_end":[35]}
{"index":1964,"text":"Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["status epilepticus"],"disease_indices_start":[100],"disease_indices_end":[118],"drugs":["pilocarpine"],"drug_indices_start":[80],"drug_indices_end":[91]}
{"index":1966,"text":"Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Metallothionein","carmustine"],"drug_indices_start":[0,147],"drug_indices_end":[157,15]}
{"index":1968,"text":"Fatal carbamazepine induced fulminant eosinophilic (hypersensitivity) myocarditis: emphasis on anatomical and histological characteristics, mechanisms and genetics of drug hypersensitivity and differential diagnosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["fulminant eosinophilic","hypersensitivity","myocarditis","drug hypersensitivity"],"disease_indices_start":[28,52,70,167],"disease_indices_end":[50,68,81,188],"drugs":["carbamazepine"],"drug_indices_start":[6],"drug_indices_end":[19]}
{"index":1970,"text":"Neuropsychiatric behaviors in the MPTP marmoset model of Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[57],"disease_indices_end":[76],"drugs":["MPTP"],"drug_indices_start":[34],"drug_indices_end":[38]}
{"index":1972,"text":"Contrast medium nephrotoxicity after renal artery and coronary angioplasty.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity"],"disease_indices_start":[16],"disease_indices_end":[30],"drugs":["Contrast medium"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":1974,"text":"Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute liver failure"],"disease_indices_start":[85],"disease_indices_end":[104],"drugs":["acetaminophen"],"drug_indices_start":[63],"drug_indices_end":[76]}
{"index":1976,"text":"Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuropathic pain"],"disease_indices_start":[115],"disease_indices_end":[131],"drugs":["morphine","sodium","CNSB002"],"drug_indices_start":[48,72,27],"drug_indices_end":[35,54,79]}
{"index":1978,"text":"Heparin-induced thrombocytopenia: a practical review.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia"],"disease_indices_start":[16],"disease_indices_end":[32],"drugs":["Heparin"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":1980,"text":"Abductor paralysis after botox injection for adductor spasmodic dysphonia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["paralysis","adductor spasmodic dysphonia"],"disease_indices_start":[9,45],"disease_indices_end":[18,73],"drugs":["botox"],"drug_indices_start":[25],"drug_indices_end":[30]}
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{"index":1984,"text":"Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolytic anemia"],"disease_indices_start":[28],"disease_indices_end":[44],"drugs":["Trimethoprim"],"drug_indices_start":[0],"drug_indices_end":[12]}
{"index":1986,"text":"Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetic nephropathy"],"disease_indices_start":[123],"disease_indices_end":[143],"drugs":["streptozotocin"],"drug_indices_start":[100],"drug_indices_end":[114]}
{"index":1988,"text":"Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mantle cell lymphoma"],"disease_indices_start":[69],"disease_indices_end":[89],"drugs":["temsirolimus"],"drug_indices_start":[42],"drug_indices_end":[54]}
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{"index":1992,"text":"Diffuse skeletal pain after administration of alendronate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[17],"disease_indices_end":[21],"drugs":["alendronate"],"drug_indices_start":[46],"drug_indices_end":[57]}
{"index":1994,"text":"Cerebrospinal fluid penetration of high-dose daptomycin in suspected Staphylococcus aureus meningitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["meningitis"],"disease_indices_start":[91],"disease_indices_end":[101],"drugs":["daptomycin"],"drug_indices_start":[45],"drug_indices_end":[55]}
{"index":1996,"text":"The role of nitric oxide in convulsions induced by lindane in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsions"],"disease_indices_start":[28],"disease_indices_end":[39],"drugs":["nitric oxide","lindane"],"drug_indices_start":[51,12],"drug_indices_end":[24,58]}
{"index":1998,"text":"Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive deficits"],"disease_indices_start":[44],"disease_indices_end":[62],"drugs":["galactose","streptozotocin"],"drug_indices_start":[122,15],"drug_indices_end":[24,136]}
{"index":2000,"text":"Tricuspid valve regurgitation and lithium carbonate toxicity in a newborn infant.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Tricuspid valve regurgitation","toxicity"],"disease_indices_start":[0,52],"disease_indices_end":[29,60],"drugs":["lithium carbonate"],"drug_indices_start":[34],"drug_indices_end":[51]}
{"index":2002,"text":"Phenobarbital-induced dyskinesia in a neurologically-impaired child.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesia","neurologically-impaired"],"disease_indices_start":[22,38],"disease_indices_end":[32,61],"drugs":["Phenobarbital"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2004,"text":"Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ammonia","valproic acid"],"drug_indices_start":[73,23],"drug_indices_end":[86,30]}
{"index":2008,"text":"Development of isoproterenol-induced cardiac hypertrophy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac hypertrophy"],"disease_indices_start":[37],"disease_indices_end":[56],"drugs":["isoproterenol"],"drug_indices_start":[15],"drug_indices_end":[28]}
{"index":2010,"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["carcinogenic","forestomach carcinogenesis"],"disease_indices_start":[3,45],"disease_indices_end":[15,71],"drugs":["retinyl acetate","butylated hydroxyanisole"],"drug_indices_start":[26,103],"drug_indices_end":[41,127]}
{"index":2012,"text":"Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscle rigidity"],"disease_indices_start":[52],"disease_indices_end":[67],"drugs":["Ketanserin","alfentanil"],"drug_indices_start":[0,33],"drug_indices_end":[10,43]}
{"index":2014,"text":"Glycopyrronium requirements for antagonism of the muscarinic side effects of edrophonium.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Glycopyrronium","edrophonium"],"drug_indices_start":[0,77],"drug_indices_end":[88,14]}
{"index":2016,"text":"Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscular rigidity"],"disease_indices_start":[87],"disease_indices_end":[104],"drugs":["fentanyl"],"drug_indices_start":[70],"drug_indices_end":[78]}
{"index":2018,"text":"Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cerebral sinus thrombosis","menorrhagia"],"disease_indices_start":[0,81],"disease_indices_end":[25,92],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2020,"text":"Hemorrhagic cystitis complicating bone marrow transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hemorrhagic cystitis","Hemorrhagic","cystitis"],"disease_indices_start":[0,12],"disease_indices_end":[11,20],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2022,"text":"Reversal of central benzodiazepine effects by flumazenil after intravenous conscious sedation with diazepam and opioids: report of a double-blind multicenter study. The Flumazenil in Intravenous Conscious Sedation with Diazepam Multicenter Study Group II.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["benzodiazepine","flumazenil","diazepam","Flumazenil","Diazepam"],"drug_indices_start":[99,169,46,20,219],"drug_indices_end":[34,227,107,179,56]}
{"index":2024,"text":"Hepatic adenomas and focal nodular hyperplasia of the liver in young women on oral contraceptives: case reports.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["adenomas","focal nodular hyperplasia"],"disease_indices_start":[8,21],"disease_indices_end":[16,46],"drugs":["oral contraceptives"],"drug_indices_start":[78],"drug_indices_end":[97]}
{"index":2026,"text":"Arterial thromboembolism in patients receiving systemic heparin therapy: a complication associated with heparin-induced thrombocytopenia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thromboembolism","thrombocytopenia"],"disease_indices_start":[9,120],"disease_indices_end":[24,136],"drugs":["heparin","heparin"],"drug_indices_start":[56,104],"drug_indices_end":[111,63]}
{"index":2028,"text":"Long-term prognosis for transplant-free survivors of paracetamol-induced acute liver failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute liver failure"],"disease_indices_start":[73],"disease_indices_end":[92],"drugs":["paracetamol"],"drug_indices_start":[53],"drug_indices_end":[64]}
{"index":2030,"text":"Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["psychosis"],"disease_indices_start":[69],"disease_indices_end":[78],"drugs":["Serotonin","methamphetamine"],"drug_indices_start":[0,45],"drug_indices_end":[9,60]}
{"index":2032,"text":"Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[87],"disease_indices_end":[95],"drugs":["bupropion hydrochloride"],"drug_indices_start":[55],"drug_indices_end":[78]}
{"index":2034,"text":"Detailed spectral profile analysis of penicillin-induced epileptiform activity in anesthetized rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epileptiform activity"],"disease_indices_start":[57],"disease_indices_end":[78],"drugs":["penicillin"],"drug_indices_start":[38],"drug_indices_end":[48]}
{"index":2036,"text":"High dose dexmedetomidine as the sole sedative for pediatric MRI.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["dexmedetomidine"],"drug_indices_start":[10],"drug_indices_end":[25]}
{"index":2038,"text":"Methamphetamine causes alterations in the MAP kinase-related pathways in the brains of mice that display increased aggressiveness.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aggressiveness"],"disease_indices_start":[115],"disease_indices_end":[129],"drugs":["Methamphetamine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":2040,"text":"Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myoclonus","idiopathic generalized epilepsies"],"disease_indices_start":[52,65],"disease_indices_end":[61,98],"drugs":["Lamotrigine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":2042,"text":"rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias","Parkinson disease"],"disease_indices_start":[59,74],"disease_indices_end":[70,91],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2044,"text":"Assessment of the onset and persistence of amnesia during procedural sedation with propofol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[43],"disease_indices_end":[50],"drugs":["propofol"],"drug_indices_start":[83],"drug_indices_end":[91]}
{"index":2046,"text":"Assessment of perinatal hepatitis B and rubella prevention in New Hampshire delivery hospitals.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis B","rubella"],"disease_indices_start":[24,40],"disease_indices_end":[35,47],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2050,"text":"Mitochondrial DNA and its respiratory chain products are defective in doxorubicin nephrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrosis"],"disease_indices_start":[82],"disease_indices_end":[91],"drugs":["doxorubicin"],"drug_indices_start":[70],"drug_indices_end":[81]}
{"index":2052,"text":"Amphotericin B-induced seizures in a patient with AIDS.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures","AIDS"],"disease_indices_start":[23,50],"disease_indices_end":[31,54],"drugs":["Amphotericin B"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":2054,"text":"Therapeutic drug monitoring of tobramycin: once-daily versus twice-daily dosage schedules.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["tobramycin"],"drug_indices_start":[31],"drug_indices_end":[41]}
{"index":2056,"text":"Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiomyopathy"],"disease_indices_start":[112],"disease_indices_end":[126],"drugs":["anthracycline","SM-5887","doxorubicin"],"drug_indices_start":[92,37,63],"drug_indices_end":[50,70,103]}
{"index":2058,"text":"Posteroventral medial pallidotomy in advanced Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[46],"disease_indices_end":[65],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2060,"text":"Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["temporal lobe epilepsy"],"disease_indices_start":[60],"disease_indices_end":[82],"drugs":["pilocarpine"],"drug_indices_start":[39],"drug_indices_end":[50]}
{"index":2064,"text":"Liposomal daunorubicin in advanced Kaposi's sarcoma: a phase II study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Kaposi's sarcoma"],"disease_indices_start":[35],"disease_indices_end":[51],"drugs":["daunorubicin"],"drug_indices_start":[10],"drug_indices_end":[22]}
{"index":2066,"text":"Failure of ancrod in the treatment of heparin-induced arterial thrombosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombosis"],"disease_indices_start":[63],"disease_indices_end":[73],"drugs":["heparin"],"drug_indices_start":[38],"drug_indices_end":[45]}
{"index":2068,"text":"Seizure after flumazenil administration in a pediatric patient.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Seizure"],"disease_indices_start":[0],"disease_indices_end":[7],"drugs":["flumazenil"],"drug_indices_start":[14],"drug_indices_end":[24]}
{"index":2070,"text":"Remodelling of nerve structure in experimental isoniazid neuropathy in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuropathy"],"disease_indices_start":[57],"disease_indices_end":[67],"drugs":["isoniazid"],"drug_indices_start":[47],"drug_indices_end":[56]}
{"index":2072,"text":"Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular fibrillation"],"disease_indices_start":[111],"disease_indices_end":[135],"drugs":["iopentol","iohexol","metrizoate"],"drug_indices_start":[33,45,23],"drug_indices_end":[40,55,31]}
{"index":2074,"text":"Magnetic resonance imaging of cerebral venous thrombosis secondary to \"low-dose\" birth control pills.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["venous thrombosis"],"disease_indices_start":[39],"disease_indices_end":[56],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2076,"text":"Relation of perfusion defects observed with myocardial contrast echocardiography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomography.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coronary stenosis"],"disease_indices_start":[100],"disease_indices_end":[117],"drugs":["thallium"],"drug_indices_start":[136],"drug_indices_end":[144]}
{"index":2078,"text":"Potential deleterious effect of furosemide in radiocontrast nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[60],"disease_indices_end":[71],"drugs":["furosemide"],"drug_indices_start":[32],"drug_indices_end":[42]}
{"index":2080,"text":"The renal pathology in a case of lithium-induced diabetes insipidus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetes insipidus"],"disease_indices_start":[49],"disease_indices_end":[67],"drugs":["lithium"],"drug_indices_start":[33],"drug_indices_end":[40]}
{"index":2081,"text":"A case of lithium-induced diabetes insipidus is reported. At necropsy microscopy shoed unique and extensive damage to cells lining the distal nephron. It is suggested that these changes represent a specific toxic effect of lithium, reported here for the first time in man.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetes insipidus"],"disease_indices_start":[95],"disease_indices_end":[113],"drugs":["lithium","lithium"],"drug_indices_start":[292,79],"drug_indices_end":[299,86]}
{"index":2082,"text":"Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptives.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["liver tumors"],"disease_indices_start":[41],"disease_indices_end":[53],"drugs":["oral contraceptives"],"drug_indices_start":[70],"drug_indices_end":[89]}
{"index":2084,"text":"Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Graft-versus-host disease","sinusoidal obstruction syndrome","microangiopathy"],"disease_indices_start":[0,108,144],"disease_indices_end":[25,139,159],"drugs":["everolimus","tacrolimus"],"drug_indices_start":[58,43],"drug_indices_end":[68,53]}
{"index":2086,"text":"Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["loreclezole","valproate","clonazepam"],"drug_indices_start":[57,108,95],"drug_indices_end":[104,68,118]}
{"index":2088,"text":"Acute liver failure with concurrent bupropion and carbimazole therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute liver failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["bupropion","carbimazole"],"drug_indices_start":[50,36],"drug_indices_end":[61,45]}
{"index":2092,"text":"Passage of mannitol into the brain around gliomas: a potential cause of rebound phenomenon. A study on 21 patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["gliomas"],"disease_indices_start":[42],"disease_indices_end":[49],"drugs":["mannitol"],"drug_indices_start":[11],"drug_indices_end":[19]}
{"index":2094,"text":"Can lidocaine reduce succinylcholine induced postoperative myalgia?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["postoperative myalgia"],"disease_indices_start":[45],"disease_indices_end":[66],"drugs":["lidocaine","succinylcholine"],"drug_indices_start":[4,21],"drug_indices_end":[36,13]}
{"index":2096,"text":"Open-label assessment of levofloxacin for the treatment of acute bacterial sinusitis in adults.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sinusitis"],"disease_indices_start":[75],"disease_indices_end":[84],"drugs":["levofloxacin"],"drug_indices_start":[25],"drug_indices_end":[37]}
{"index":2098,"text":"Clinical evaluation on combined administration of oral prostacyclin analogue beraprost and phosphodiesterase inhibitor cilostazol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["prostacyclin","beraprost","cilostazol"],"drug_indices_start":[119,77,55],"drug_indices_end":[129,67,86]}
{"index":2100,"text":"Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II).","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rheumatoid arthritis"],"disease_indices_start":[47],"disease_indices_end":[67],"drugs":["etoricoxib","etoricoxib","diclofenac sodium"],"drug_indices_start":[33,107,93],"drug_indices_end":[43,124,103]}
{"index":2102,"text":"Placebo-level incidence of extrapyramidal symptoms (EPS) with quetiapine in controlled studies of patients with bipolar mania.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["extrapyramidal symptoms","EPS","bipolar mania"],"disease_indices_start":[27,52,112],"disease_indices_end":[50,55,125],"drugs":["quetiapine"],"drug_indices_start":[62],"drug_indices_end":[72]}
{"index":2104,"text":"Contribution of the sympathetic nervous system to salt-sensitivity in lifetime captopril-treated spontaneously hypertensive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[111],"disease_indices_end":[123],"drugs":["captopril"],"drug_indices_start":[79],"drug_indices_end":[88]}
{"index":2106,"text":"Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuropathy"],"disease_indices_start":[106],"disease_indices_end":[116],"drugs":["corticosterone","organophosphorus"],"drug_indices_start":[73,55],"drug_indices_end":[89,69]}
{"index":2108,"text":"In vivo characterization of a dual adenosine A2A\/A1 receptor antagonist in animal models of Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[92],"disease_indices_end":[111],"drugs":["adenosine A2A\/A1 receptor antagonist"],"drug_indices_start":[35],"drug_indices_end":[71]}
{"index":2110,"text":"An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["delusional parasitosis","chronic hepatitis C"],"disease_indices_start":[26,54],"disease_indices_end":[48,73],"drugs":["pegylated interferon alpha-2b","ribavirin"],"drug_indices_start":[89,123],"drug_indices_end":[132,118]}
{"index":2112,"text":"Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuroleptic malignant syndrome"],"disease_indices_start":[9],"disease_indices_end":[39],"drugs":["paroxetine","alprazolam"],"drug_indices_start":[93,78],"drug_indices_end":[88,103]}
{"index":2114,"text":"Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures","impairment in auditory location discrimination"],"disease_indices_start":[12,41],"disease_indices_end":[20,87],"drugs":["Pilocarpine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":2116,"text":"Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["cyclooxygenase inhibitors"],"drug_indices_start":[25],"drug_indices_end":[50]}
{"index":2118,"text":"Predictors of decreased renal function in patients with heart failure during angiotensin-converting enzyme inhibitor therapy: results from the studies of left ventricular dysfunction (SOLVD)","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["decreased renal function","heart failure","left ventricular dysfunction"],"disease_indices_start":[14,56,154],"disease_indices_end":[38,69,182],"drugs":["angiotensin"],"drug_indices_start":[77],"drug_indices_end":[88]}
{"index":2120,"text":"Pemoline induced acute choreoathetosis: case report and review of the literature.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["choreoathetosis"],"disease_indices_start":[23],"disease_indices_end":[38],"drugs":["Pemoline"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":2122,"text":"Continuous subcutaneous administration of mesna to prevent ifosfamide-induced hemorrhagic cystitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhagic cystitis","hemorrhagic","cystitis"],"disease_indices_start":[78,90],"disease_indices_end":[89,98],"drugs":["mesna","ifosfamide"],"drug_indices_start":[42,59],"drug_indices_end":[69,47]}
{"index":2124,"text":"Modification of drug action by hyperammonemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hyperammonemia"],"disease_indices_start":[31],"disease_indices_end":[45],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2126,"text":"Risk of nephropathy after consumption of nonionic contrast media by children undergoing cardiac angiography: a prospective study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[8],"disease_indices_end":[19],"drugs":["contrast media"],"drug_indices_start":[50],"drug_indices_end":[64]}
{"index":2128,"text":"A case of ventricular tachycardia related to caffeine pretreatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia"],"disease_indices_start":[10],"disease_indices_end":[33],"drugs":["caffeine"],"drug_indices_start":[45],"drug_indices_end":[53]}
{"index":2130,"text":"Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["optic neuropathy"],"disease_indices_start":[89],"disease_indices_end":[105],"drugs":["ethambutol"],"drug_indices_start":[70],"drug_indices_end":[80]}
{"index":2132,"text":"Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombotic","arthritis"],"disease_indices_start":[136,171],"disease_indices_end":[146,180],"drugs":["valdecoxib"],"drug_indices_start":[51],"drug_indices_end":[61]}
{"index":2134,"text":"A randomized, placebo-controlled, crossover study of ephedrine for SSRI-induced female sexual dysfunction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sexual dysfunction"],"disease_indices_start":[87],"disease_indices_end":[105],"drugs":["ephedrine"],"drug_indices_start":[53],"drug_indices_end":[62]}
{"index":2136,"text":"Erectile dysfunction occurs following substantia nigra lesions in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Erectile dysfunction"],"disease_indices_start":[0],"disease_indices_end":[20],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2138,"text":"Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["parkinsonian"],"disease_indices_start":[100],"disease_indices_end":[112],"drugs":["dopamine","A-86929","levodopa"],"drug_indices_start":[73,43,113],"drug_indices_end":[80,121,51]}
{"index":2140,"text":"Deaths from local anesthetic-induced convulsions in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsions"],"disease_indices_start":[37],"disease_indices_end":[48],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2142,"text":"Myoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Myoclonic, atonic, and absence seizures","Myoclonic","absence seizures"],"disease_indices_start":[0,23],"disease_indices_end":[9,39],"drugs":["carbamazepine"],"drug_indices_start":[65],"drug_indices_end":[78]}
{"index":2144,"text":"Naloxone reversal of hypotension due to captopril overdose.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","overdose"],"disease_indices_start":[21,50],"disease_indices_end":[32,58],"drugs":["Naloxone","captopril"],"drug_indices_start":[0,40],"drug_indices_end":[8,49]}
{"index":2146,"text":"Carbamazepine-induced cardiac dysfunction. Characterization of two distinct clinical syndromes.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac dysfunction"],"disease_indices_start":[22],"disease_indices_end":[41],"drugs":["Carbamazepine"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2148,"text":"Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[119],"disease_indices_end":[128],"drugs":["NMDA","haloperidol"],"drug_indices_start":[99,44],"drug_indices_end":[48,110]}
{"index":2150,"text":"Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Parkinson's disease"],"disease_indices_start":[87],"disease_indices_end":[106],"drugs":["glutamate"],"drug_indices_start":[13],"drug_indices_end":[22]}
{"index":2152,"text":"Nimodipine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["memory impairment","hypotension"],"disease_indices_start":[20,70],"disease_indices_end":[37,81],"drugs":["Nimodipine","nitroglycerin"],"drug_indices_start":[0,48],"drug_indices_end":[10,61]}
{"index":2154,"text":"Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["haemopericardium","gastrointestinal haemorrhage"],"disease_indices_start":[6,27],"disease_indices_end":[22,55],"drugs":["warfarin"],"drug_indices_start":[108],"drug_indices_end":[116]}
{"index":2156,"text":"Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial injury"],"disease_indices_start":[81],"disease_indices_end":[98],"drugs":["Isoproterenol"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2158,"text":"High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["obese","cardiotoxicity"],"disease_indices_start":[18,73],"disease_indices_end":[23,87],"drugs":["fat","doxorubicin"],"drug_indices_start":[53,5],"drug_indices_end":[8,64]}
{"index":2160,"text":"Complete atrioventricular block secondary to lithium therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrioventricular block"],"disease_indices_start":[9],"disease_indices_end":[31],"drugs":["lithium"],"drug_indices_start":[45],"drug_indices_end":[52]}
{"index":2162,"text":"Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Neuroleptic malignant syndrome"],"disease_indices_start":[0],"disease_indices_end":[30],"drugs":["ziprasidone"],"drug_indices_start":[42],"drug_indices_end":[53]}
{"index":2164,"text":"Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[94],"disease_indices_end":[115],"drugs":["mangiferin","isoproterenol"],"drug_indices_start":[8,72],"drug_indices_end":[18,85]}
{"index":2166,"text":"Remifentanil pretreatment reduces myoclonus after etomidate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myoclonus"],"disease_indices_start":[34],"disease_indices_end":[43],"drugs":["Remifentanil","etomidate"],"drug_indices_start":[0,50],"drug_indices_end":[59,12]}
{"index":2168,"text":"Daidzein activates choline acetyltransferase from MC-IXC cells and improves drug-induced amnesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[89],"disease_indices_end":[96],"drugs":["Daidzein","choline"],"drug_indices_start":[0,19],"drug_indices_end":[8,26]}
{"index":2170,"text":"Possible azithromycin-associated hiccups.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hiccups"],"disease_indices_start":[33],"disease_indices_end":[40],"drugs":["azithromycin"],"drug_indices_start":[9],"drug_indices_end":[21]}
{"index":2172,"text":"Time trends in warfarin-associated hemorrhage.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemorrhage"],"disease_indices_start":[35],"disease_indices_end":[45],"drugs":["warfarin"],"drug_indices_start":[15],"drug_indices_end":[23]}
{"index":2174,"text":"Fatal haemorrhagic myocarditis secondary to cyclophosphamide therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["haemorrhagic myocarditis","haemorrhagic","myocarditis"],"disease_indices_start":[6,19],"disease_indices_end":[18,30],"drugs":["cyclophosphamide"],"drug_indices_start":[44],"drug_indices_end":[60]}
{"index":2175,"text":"Haemorrhagic myocarditis is a rare but important complication of cyclophosphamide therapy. Echocardiographic identification of the disorder can be made. We believe that the ultrasound features of this disorder have not been previously reported.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Haemorrhagic myocarditis","Haemorrhagic","myocarditis"],"disease_indices_start":[70,83],"disease_indices_end":[82,94],"drugs":["cyclophosphamide"],"drug_indices_start":[135],"drug_indices_end":[151]}
{"index":2176,"text":"Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["migraine without aura","migraine with aura"],"disease_indices_start":[39,77],"disease_indices_end":[60,95],"drugs":["Glyceryl trinitrate"],"drug_indices_start":[0],"drug_indices_end":[19]}
{"index":2178,"text":"Stroke and cocaine or amphetamine use.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Stroke"],"disease_indices_start":[0],"disease_indices_end":[6],"drugs":["cocaine","amphetamine"],"drug_indices_start":[11,22],"drug_indices_end":[33,18]}
{"index":2180,"text":"Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast cancer"],"disease_indices_start":[14],"disease_indices_end":[27],"drugs":["tamoxifen","Tamoxifen"],"drug_indices_start":[136,33],"drug_indices_end":[145,42]}
{"index":2182,"text":"A measure of pupillary oscillation as a marker of cocaine-induced paranoia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pupillary oscillation","paranoia"],"disease_indices_start":[13,66],"disease_indices_end":[34,74],"drugs":["cocaine"],"drug_indices_start":[50],"drug_indices_end":[57]}
{"index":2184,"text":"Seizures induced by combined levomepromazine-fluvoxamine treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Seizures"],"disease_indices_start":[0],"disease_indices_end":[8],"drugs":["levomepromazine","fluvoxamine"],"drug_indices_start":[45,29],"drug_indices_end":[56,44]}
{"index":2185,"text":"We report a case of combined levomepromazine-fluvoxamine treatment-induced seizures. It seems that combined treatment of fluvoxamine with phenothiazines may possess proconvulsive activity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[143],"disease_indices_end":[151],"drugs":["levomepromazine","fluvoxamine","fluvoxamine","phenothiazines"],"drug_indices_start":[97,206,189,113],"drug_indices_end":[112,220,124,200]}
{"index":2186,"text":"Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myopathy"],"disease_indices_start":[48],"disease_indices_end":[56],"drugs":["epsilon-aminocaproic acid","EACA"],"drug_indices_start":[8,35],"drug_indices_end":[33,39]}
{"index":2187,"text":"A case of necrotizing myopathy due to a short epsilon-aminocaproic acid (EACA) treatment in a 72 year-old patient with subarachnoid haemorrhage (SAH) is described. Pathogenetic hypotheses are discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["necrotizing myopathy","necrotizing","myopathy","subarachnoid haemorrhage","SAH"],"disease_indices_start":[115,127,224,250],"disease_indices_end":[126,135,248,253],"drugs":["epsilon-aminocaproic acid","EACA"],"drug_indices_start":[178,151],"drug_indices_end":[176,182]}
{"index":2188,"text":"Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ranitidine","cimetidine"],"drug_indices_start":[50,35],"drug_indices_end":[60,45]}
{"index":2190,"text":"A catch in the Reye.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Reye"],"disease_indices_start":[15],"disease_indices_end":[19],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2192,"text":"St. Anthony's fire, then and now: a case report and historical review.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["St. Anthony's fire"],"disease_indices_start":[0],"disease_indices_end":[18],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2194,"text":"Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypokalemia"],"disease_indices_start":[29],"disease_indices_end":[40],"drugs":["oxprenolol"],"drug_indices_start":[64],"drug_indices_end":[74]}
{"index":2196,"text":"Midline B3 serotonin nerves in rat medulla are involved in hypotensive effect of methyldopa.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotensive"],"disease_indices_start":[59],"disease_indices_end":[70],"drugs":["serotonin","methyldopa"],"drug_indices_start":[81,11],"drug_indices_end":[91,20]}
{"index":2198,"text":"Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sexual side effects"],"disease_indices_start":[23],"disease_indices_end":[42],"drugs":["Yohimbine","serotonin"],"drug_indices_start":[0,54],"drug_indices_end":[9,63]}
{"index":2200,"text":"Hypersensitivity immune reaction as a mechanism for dilevalol-associated hepatitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypersensitivity","hepatitis"],"disease_indices_start":[0,73],"disease_indices_end":[16,82],"drugs":["dilevalol"],"drug_indices_start":[52],"drug_indices_end":[61]}
{"index":2202,"text":"Reversible myocardial hypertrophy induced by tacrolimus in a pediatric heart transplant recipient: case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial hypertrophy"],"disease_indices_start":[11],"disease_indices_end":[33],"drugs":["tacrolimus"],"drug_indices_start":[45],"drug_indices_end":[55]}
{"index":2204,"text":"Comparison of unilateral pallidotomy and subthalamotomy findings in advanced idiopathic Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["idiopathic Parkinson's disease"],"disease_indices_start":[77],"disease_indices_end":[107],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2206,"text":"Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrosis"],"disease_indices_start":[64],"disease_indices_end":[73],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[38],"drug_indices_end":[63]}
{"index":2208,"text":"Reverse or inverted left ventricular apical ballooning syndrome (reverse Takotsubo cardiomyopathy) in a young woman in the setting of amphetamine use.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["left ventricular apical ballooning syndrome","Takotsubo cardiomyopathy"],"disease_indices_start":[20,73],"disease_indices_end":[63,97],"drugs":["amphetamine"],"drug_indices_start":[134],"drug_indices_end":[145]}
{"index":2210,"text":"Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["corticosterone"],"drug_indices_start":[115],"drug_indices_end":[129]}
{"index":2212,"text":"Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["degeneration of dopaminergic neurons"],"disease_indices_start":[32],"disease_indices_end":[68],"drugs":["iron dextran"],"drug_indices_start":[11],"drug_indices_end":[23]}
{"index":2214,"text":"Warfarin-induced leukocytoclastic vasculitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["leukocytoclastic vasculitis"],"disease_indices_start":[17],"disease_indices_end":[44],"drugs":["Warfarin"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":2216,"text":"The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["spinal cord ischemia"],"disease_indices_start":[174],"disease_indices_end":[194],"drugs":["N-methyl-D-aspartate","morphine"],"drug_indices_start":[25,132],"drug_indices_end":[140,45]}
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{"index":2370,"text":"Clarithromycin-induced ventricular tachycardia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia"],"disease_indices_start":[23],"disease_indices_end":[46],"drugs":["Clarithromycin"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":2372,"text":"Persistent nephrogenic diabetes insipidus following lithium therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrogenic diabetes insipidus"],"disease_indices_start":[11],"disease_indices_end":[41],"drugs":["lithium"],"drug_indices_start":[52],"drug_indices_end":[59]}
{"index":2374,"text":"Late cardiotoxicity after treatment for a malignant bone tumor.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity","bone tumor"],"disease_indices_start":[5,52],"disease_indices_end":[19,62],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2376,"text":"Venous complications of midazolam versus diazepam.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Venous complications"],"disease_indices_start":[0],"disease_indices_end":[20],"drugs":["midazolam","diazepam"],"drug_indices_start":[24,41],"drug_indices_end":[33,49]}
{"index":2378,"text":"Tetany and rhabdomyolysis due to surreptitious furosemide--importance of magnesium supplementation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Tetany","rhabdomyolysis"],"disease_indices_start":[0,11],"disease_indices_end":[6,25],"drugs":["furosemide","magnesium"],"drug_indices_start":[73,47],"drug_indices_end":[57,82]}
{"index":2380,"text":"Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[111],"disease_indices_end":[119],"drugs":["glutamate","pilocarpine"],"drug_indices_start":[8,91],"drug_indices_end":[17,102]}
{"index":2382,"text":"Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal dysfunction"],"disease_indices_start":[57],"disease_indices_end":[74],"drugs":["misoprostol","indomethacin"],"drug_indices_start":[36,21],"drug_indices_end":[32,48]}
{"index":2384,"text":"Nephrotoxic effects of aminoglycoside treatment on renal protein reabsorption and accumulation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Nephrotoxic"],"disease_indices_start":[0],"disease_indices_end":[11],"drugs":["aminoglycoside"],"drug_indices_start":[23],"drug_indices_end":[37]}
{"index":2386,"text":"Pharmacology of GYKI-41 099 (chlorpropanol, Tobanum) a new potent beta-adrenergic antagonist.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["GYKI-41 099","chlorpropanol","Tobanum"],"drug_indices_start":[16,44,29],"drug_indices_end":[51,42,27]}
{"index":2388,"text":"Chorea associated with oral contraception.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Chorea"],"disease_indices_start":[0],"disease_indices_end":[6],"drugs":["oral contraception"],"drug_indices_start":[23],"drug_indices_end":[41]}
{"index":2390,"text":"Reversal of ammonia coma in rats by L-dopa: a peripheral effect.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["coma"],"disease_indices_start":[20],"disease_indices_end":[24],"drugs":["ammonia","L-dopa"],"drug_indices_start":[12,36],"drug_indices_end":[42,19]}
{"index":2392,"text":"Heparin-induced thrombocytopenia after liver transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["thrombocytopenia"],"disease_indices_start":[16],"disease_indices_end":[32],"drugs":["Heparin"],"drug_indices_start":[0],"drug_indices_end":[7]}
{"index":2394,"text":"PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vasculitis","Turner Syndrome","Graves' disease"],"disease_indices_start":[15,41,61],"disease_indices_end":[25,56,76],"drugs":["PTU"],"drug_indices_start":[0],"drug_indices_end":[3]}
{"index":2396,"text":"Succinylcholine-induced masseter muscle rigidity during bronchoscopic removal of a tracheal foreign body.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["masseter muscle rigidity"],"disease_indices_start":[24],"disease_indices_end":[48],"drugs":["Succinylcholine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":2398,"text":"Minor neurological dysfunction, cognitive development, and somatic development at the age of 3 to 7 years after dexamethasone treatment in very-low birth-weight infants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurological dysfunction"],"disease_indices_start":[6],"disease_indices_end":[30],"drugs":["dexamethasone"],"drug_indices_start":[112],"drug_indices_end":[125]}
{"index":2400,"text":"Force overflow and levodopa-induced dyskinesias in Parkinson's disease.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dyskinesias","Parkinson's disease"],"disease_indices_start":[36,51],"disease_indices_end":[47,70],"drugs":["levodopa"],"drug_indices_start":[19],"drug_indices_end":[27]}
{"index":2402,"text":"Postinfarction ventricular septal defect associated with long-term steroid therapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular septal defect"],"disease_indices_start":[15],"disease_indices_end":[40],"drugs":["steroid"],"drug_indices_start":[67],"drug_indices_end":[74]}
{"index":2403,"text":"Two cases of postinfarction ventricular septal rupture in patients on long-term steroid therapy are presented and the favourable outcome in both cases described. A possible association between steroid therapy and subsequent postinfarction septal rupture is discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular septal rupture","septal rupture"],"disease_indices_start":[112,323],"disease_indices_end":[138,337],"drugs":["steroid","steroid"],"drug_indices_start":[164,277],"drug_indices_end":[171,284]}
{"index":2404,"text":"Angioedema associated with droperidol administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Angioedema"],"disease_indices_start":[0],"disease_indices_end":[10],"drugs":["droperidol"],"drug_indices_start":[27],"drug_indices_end":[37]}
{"index":2406,"text":"Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["visual hallucinations","chronic renal failure"],"disease_indices_start":[26,66],"disease_indices_end":[47,87],"drugs":["Clarithromycin"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":2408,"text":"Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["renal toxicity"],"disease_indices_start":[6],"disease_indices_end":[20],"drugs":["doxorubicin","adriamycin","cyanoacrylate"],"drug_indices_start":[24,56,37],"drug_indices_end":[35,69,47]}
{"index":2410,"text":"Etoposide-related myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[18],"disease_indices_end":[39],"drugs":["Etoposide"],"drug_indices_start":[0],"drug_indices_end":[9]}
{"index":2411,"text":"The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease. Possible causal mechanisms are discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction","coronary heart disease"],"disease_indices_start":[61,170],"disease_indices_end":[82,192],"drugs":["etoposide"],"drug_indices_start":[125],"drug_indices_end":[134]}
{"index":2412,"text":"Subjective assessment of sexual dysfunction of patients on long-term administration of digoxin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["sexual dysfunction"],"disease_indices_start":[25],"disease_indices_end":[43],"drugs":["digoxin"],"drug_indices_start":[87],"drug_indices_end":[94]}
{"index":2414,"text":"Fatal aplastic anemia due to indomethacin--lymphocyte transformation tests in vitro.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aplastic anemia"],"disease_indices_start":[6],"disease_indices_end":[21],"drugs":["indomethacin"],"drug_indices_start":[29],"drug_indices_end":[41]}
{"index":2416,"text":"Plasma and urinary lipids and lipoproteins during the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotic syndrome"],"disease_indices_start":[69],"disease_indices_end":[87],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[110],"drug_indices_end":[135]}
{"index":2418,"text":"Circulating lysosomal enzymes and acute hepatic necrosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute hepatic necrosis"],"disease_indices_start":[34],"disease_indices_end":[56],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2420,"text":"Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Wernicke's encephalopathy"],"disease_indices_start":[48],"disease_indices_end":[73],"drugs":["tolazamide"],"drug_indices_start":[29],"drug_indices_end":[39]}
{"index":2422,"text":"Mechanisms of myocardial ischemia induced by epinephrine: comparison with exercise-induced ischemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial ischemia","ischemia"],"disease_indices_start":[14,91],"disease_indices_end":[33,99],"drugs":["epinephrine"],"drug_indices_start":[45],"drug_indices_end":[56]}
{"index":2424,"text":"Transient contralateral rotation following unilateral substantia nigra lesion reflects susceptibility of the nigrostriatal system to exhaustion by amphetamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["contralateral rotation","substantia nigra lesion"],"disease_indices_start":[10,54],"disease_indices_end":[32,77],"drugs":["amphetamine"],"drug_indices_start":[147],"drug_indices_end":[158]}
{"index":2426,"text":"Thyroid function and urine-concentrating ability during lithium treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["lithium"],"drug_indices_start":[56],"drug_indices_end":[63]}
{"index":2428,"text":"Sensitivity of erythroid progenitor colonies to erythropoietin in azidothymidine treated immunodeficient mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["immunodeficient"],"disease_indices_start":[89],"disease_indices_end":[104],"drugs":["azidothymidine"],"drug_indices_start":[66],"drug_indices_end":[80]}
{"index":2430,"text":"Detection of abnormal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiomyopathy"],"disease_indices_start":[79],"disease_indices_end":[93],"drugs":["adriamycin","iodine-125-metaiodobenzylguanidine"],"drug_indices_start":[99,60],"drug_indices_end":[133,70]}
{"index":2432,"text":"Amnestic syndrome associated with propranolol toxicity: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Amnestic syndrome","toxicity"],"disease_indices_start":[0,46],"disease_indices_end":[17,54],"drugs":["propranolol"],"drug_indices_start":[34],"drug_indices_end":[45]}
{"index":2434,"text":"Biphasic response of the SA node of the dog heart in vivo to selective administration of ketamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["ketamine"],"drug_indices_start":[89],"drug_indices_end":[97]}
{"index":2436,"text":"The use of serum cholinesterase in succinylcholine apnoea.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["apnoea"],"disease_indices_start":[51],"disease_indices_end":[57],"drugs":["succinylcholine"],"drug_indices_start":[35],"drug_indices_end":[50]}
{"index":2438,"text":"Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Orthostatic hypotension","hypertensive"],"disease_indices_start":[0,126],"disease_indices_end":[23,138],"drugs":["prazosin"],"drug_indices_start":[82],"drug_indices_end":[90]}
{"index":2440,"text":"Coexistence of cerebral venous sinus and internal carotid artery thrombosis associated with exogenous sex hormones. A case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cerebral venous sinus and internal carotid artery thrombosis","cerebral venous sinus","internal carotid artery thrombosis"],"disease_indices_start":[15,41],"disease_indices_end":[36,75],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2442,"text":"Chloroquine related complete heart block with blindness: case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart block","blindness"],"disease_indices_start":[29,46],"disease_indices_end":[40,55],"drugs":["Chloroquine"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":2444,"text":"Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[9],"disease_indices_end":[17],"drugs":["bupivacaine","levobupivacaine","ropivacaine"],"drug_indices_start":[74,53,39],"drug_indices_end":[50,68,85]}
{"index":2446,"text":"22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["secondary hyperparathyroidism","low bone turnover","renal failure"],"disease_indices_start":[28,75,106],"disease_indices_end":[57,92,119],"drugs":["22-oxacalcitriol"],"drug_indices_start":[0],"drug_indices_end":[16]}
{"index":2448,"text":"Chemotherapy of advanced inoperable non-small cell lung cancer with paclitaxel: a phase II trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["non-small cell lung cancer"],"disease_indices_start":[36],"disease_indices_end":[62],"drugs":["paclitaxel"],"drug_indices_start":[68],"drug_indices_end":[78]}
{"index":2450,"text":"Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cerebral hemorrhage"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["phenylpropanolamine","caffeine"],"drug_indices_start":[36,76],"drug_indices_end":[84,55]}
{"index":2452,"text":"Long-term efficacy and toxicity of high-dose amiodarone therapy for ventricular tachycardia or ventricular fibrillation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity","ventricular tachycardia","ventricular fibrillation"],"disease_indices_start":[23,68,95],"disease_indices_end":[31,91,119],"drugs":["amiodarone"],"drug_indices_start":[45],"drug_indices_end":[55]}
{"index":2454,"text":"Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[70],"disease_indices_end":[78],"drugs":["calcium chloride","4-aminopyridine","desipramine"],"drug_indices_start":[10,58,31],"drug_indices_end":[26,69,46]}
{"index":2456,"text":"Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuroblastoma"],"disease_indices_start":[55],"disease_indices_end":[68],"drugs":["13-cis-retinoic acid"],"drug_indices_start":[17],"drug_indices_end":[37]}
{"index":2458,"text":"Effect of calcium chloride on gross behavioural changes produced by carbachol and eserine in cats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["calcium chloride","carbachol","eserine"],"drug_indices_start":[10,68,82],"drug_indices_end":[89,26,77]}
{"index":2460,"text":"Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rheumatoid arthritis"],"disease_indices_start":[67],"disease_indices_end":[87],"drugs":["penicillamine"],"drug_indices_start":[25],"drug_indices_end":[38]}
{"index":2462,"text":"Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiac arrhythmias"],"disease_indices_start":[33],"disease_indices_end":[52],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2464,"text":"Serotonergic drugs, benzodiazepines and baclofen block muscimol-induced myoclonic jerks in a strain of mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myoclonic jerks"],"disease_indices_start":[72],"disease_indices_end":[87],"drugs":["benzodiazepines","baclofen","muscimol"],"drug_indices_start":[40,20,55],"drug_indices_end":[48,35,63]}
{"index":2466,"text":"Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperglycemic acidotic coma","Hyperglycemic","acidotic","coma","Kearns-Sayre syndrome"],"disease_indices_start":[0,14,23,41],"disease_indices_end":[13,22,27,62],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2468,"text":"Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Alzheimer's disease"],"disease_indices_start":[102],"disease_indices_end":[121],"drugs":["crocin","streptozocin"],"drug_indices_start":[53,63],"drug_indices_end":[75,59]}
{"index":2470,"text":"Rosaceiform dermatitis associated with topical tacrolimus treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dermatitis"],"disease_indices_start":[12],"disease_indices_end":[22],"drugs":["tacrolimus"],"drug_indices_start":[47],"drug_indices_end":[57]}
{"index":2474,"text":"The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["pilocarpine"],"drug_indices_start":[59],"drug_indices_end":[70]}
{"index":2476,"text":"Disulfiram-induced transient optic and peripheral neuropathy: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["optic and peripheral neuropathy","optic","peripheral neuropathy"],"disease_indices_start":[29,39],"disease_indices_end":[34,60],"drugs":["Disulfiram"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":2478,"text":"Sustained clinical improvement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatitis B","cirrhosis"],"disease_indices_start":[63,89],"disease_indices_end":[74,98],"drugs":["lamivudine"],"drug_indices_start":[120],"drug_indices_end":[130]}
{"index":2480,"text":"Dual effects of melatonin on barbiturate-induced narcosis in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["narcosis"],"disease_indices_start":[49],"disease_indices_end":[57],"drugs":["melatonin","barbiturate"],"drug_indices_start":[16,29],"drug_indices_end":[40,25]}
{"index":2482,"text":"Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesia"],"disease_indices_start":[61],"disease_indices_end":[68],"drugs":["NIK-247","scopolamine"],"drug_indices_start":[41,11],"drug_indices_end":[18,52]}
{"index":2484,"text":"Nightmares and hallucinations after long-term intake of tramadol combined with antidepressants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hallucinations"],"disease_indices_start":[15],"disease_indices_end":[29],"drugs":["tramadol"],"drug_indices_start":[56],"drug_indices_end":[64]}
{"index":2486,"text":"Apparent cure of rheumatoid arthritis by bone marrow transplantation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rheumatoid arthritis"],"disease_indices_start":[17],"disease_indices_end":[37],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2488,"text":"Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["injury to different regions of the kidney"],"disease_indices_start":[54],"disease_indices_end":[95],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2490,"text":"Neuromuscular blockade with magnesium sulfate and nifedipine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Neuromuscular blockade"],"disease_indices_start":[0],"disease_indices_end":[22],"drugs":["magnesium sulfate","nifedipine"],"drug_indices_start":[50,28],"drug_indices_end":[60,45]}
{"index":2491,"text":"A patient who received tocolysis with nifedipine developed neuromuscular blockade after 500 mg of magnesium sulfate was administered. This reaction demonstrates that nifedipine can seriously potentiate the toxicity of magnesium. Caution should be exercised when these two tocolytics are combined.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neuromuscular blockade","toxicity"],"disease_indices_start":[121,268],"disease_indices_end":[143,276],"drugs":["nifedipine","magnesium sulfate","nifedipine","magnesium"],"drug_indices_start":[160,280,100,228],"drug_indices_end":[177,289,110,238]}
{"index":2492,"text":"Ifosfamide continuous infusion without mesna. A phase I trial of a 14-day cycle.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Ifosfamide","mesna"],"drug_indices_start":[0,39],"drug_indices_end":[10,44]}
{"index":2494,"text":"Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation induction: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Myocardial infarction"],"disease_indices_start":[0],"disease_indices_end":[21],"drugs":["clomiphene citrate"],"drug_indices_start":[51],"drug_indices_end":[69]}
{"index":2496,"text":"Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hepatonecrosis","cholangitis"],"disease_indices_start":[0,19],"disease_indices_end":[14,30],"drugs":["phenobarbital"],"drug_indices_start":[52],"drug_indices_end":[65]}
{"index":2498,"text":"Ethambutol-associated optic neuropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["optic neuropathy"],"disease_indices_start":[22],"disease_indices_end":[38],"drugs":["Ethambutol"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":2500,"text":"Tolerability of nimesulide and paracetamol in patients with NSAID-induced urticaria\/angioedema.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["urticaria","angioedema"],"disease_indices_start":[74,84],"disease_indices_end":[83,94],"drugs":["nimesulide","paracetamol","NSAID"],"drug_indices_start":[16,60,31],"drug_indices_end":[65,26,42]}
{"index":2502,"text":"Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["atrial fibrillation"],"disease_indices_start":[24],"disease_indices_end":[43],"drugs":["verapamil"],"drug_indices_start":[11],"drug_indices_end":[20]}
{"index":2504,"text":"Hypotension, bradycardia, and asystole after high-dose intravenous methylprednisolone in a monitored patient.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypotension","bradycardia","asystole"],"disease_indices_start":[0,13,30],"disease_indices_end":[11,24,38],"drugs":["methylprednisolone"],"drug_indices_start":[67],"drug_indices_end":[85]}
{"index":2506,"text":"Lifetime treatment of mice with azidothymidine (AZT) produces myelodysplasia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myelodysplasia"],"disease_indices_start":[62],"disease_indices_end":[76],"drugs":["azidothymidine","AZT"],"drug_indices_start":[32,48],"drug_indices_end":[51,46]}
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{"index":2656,"text":"Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiogenic shock","heart block"],"disease_indices_start":[11,42],"disease_indices_end":[28,53],"drugs":["verapamil","metoprolol"],"drug_indices_start":[60,77],"drug_indices_end":[69,87]}
{"index":2658,"text":"A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["antipurine","lometrexol","DDATHF","folic acid"],"drug_indices_start":[32,66,90,54],"drug_indices_end":[64,42,72,100]}
{"index":2660,"text":"Involvement of the mu-opiate receptor in peripheral analgesia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["analgesia"],"disease_indices_start":[52],"disease_indices_end":[61],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2662,"text":"Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemolysis","chronic hepatitis C"],"disease_indices_start":[56,125],"disease_indices_end":[65,144],"drugs":["ribavirin","interferon","ribavirin"],"drug_indices_start":[96,19,111],"drug_indices_end":[120,106,28]}
{"index":2664,"text":"Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotic syndrome"],"disease_indices_start":[102],"disease_indices_end":[120],"drugs":["puromycin aminonucleoside"],"drug_indices_start":[68],"drug_indices_end":[93]}
{"index":2666,"text":"Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["breast cancer","detrimental effect on memory and cognition","detrimental effect on memory","detrimental effect on"],"disease_indices_start":[42,63],"disease_indices_end":[55,84,91,105],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2668,"text":"Association of nitric oxide production and apoptosis in a model of experimental nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[80],"disease_indices_end":[91],"drugs":["nitric oxide"],"drug_indices_start":[15],"drug_indices_end":[27]}
{"index":2670,"text":"The attenuating effect of carteolol hydrochloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalepsy in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[106],"disease_indices_end":[115],"drugs":["carteolol hydrochloride"],"drug_indices_start":[26],"drug_indices_end":[49]}
{"index":2672,"text":"Penicillamine-induced rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glomerulonephritis","rheumatoid arthritis"],"disease_indices_start":[42,79],"disease_indices_end":[60,99],"drugs":["Penicillamine"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2674,"text":"Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azidothymidine Trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["zidovudine","Azidothymidine"],"drug_indices_start":[114,43],"drug_indices_end":[128,53]}
{"index":2676,"text":"Bilateral optic neuropathy due to combined ethambutol and isoniazid treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Bilateral optic neuropathy"],"disease_indices_start":[0],"disease_indices_end":[26],"drugs":["ethambutol","isoniazid"],"drug_indices_start":[58,43],"drug_indices_end":[67,53]}
{"index":2678,"text":"Progestational agents and blood coagulation. VII. Thromboembolic and other complications of oral contraceptive therapy in relationship to pretreatment levels of blood coagulation factors: summary report of a ten-year study.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["blood coagulation","Thromboembolic","blood coagulation"],"disease_indices_start":[26,50,161],"disease_indices_end":[43,64,178],"drugs":["oral contraceptive"],"drug_indices_start":[92],"drug_indices_end":[110]}
{"index":2680,"text":"Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiac arrest","cerebral palsy"],"disease_indices_start":[0,31],"disease_indices_end":[14,45],"drugs":["sevoflurane","clonidine"],"drug_indices_start":[112,57],"drug_indices_end":[121,68]}
{"index":2682,"text":"Effects of UMB24 and (+\/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["UMB24","SM 21","cocaine"],"drug_indices_start":[27,11,119],"drug_indices_end":[16,32,126]}
{"index":2684,"text":"Methimazole-induced cholestatic jaundice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cholestatic jaundice"],"disease_indices_start":[20],"disease_indices_end":[40],"drugs":["Methimazole"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":2686,"text":"Ciprofloxacin-induced acute interstitial nephritis and autoimmune hemolytic anemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["interstitial nephritis","autoimmune hemolytic anemia"],"disease_indices_start":[28,55],"disease_indices_end":[50,82],"drugs":["Ciprofloxacin"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2688,"text":"Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["syndrome of inappropriate secretion of antidiuretic hormone"],"disease_indices_start":[40],"disease_indices_end":[99],"drugs":["sodium valproate"],"drug_indices_start":[16],"drug_indices_end":[32]}
{"index":2690,"text":"Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension","heart failure"],"disease_indices_start":[50,72],"disease_indices_end":[61,85],"drugs":["Vasopressin","milrinone"],"drug_indices_start":[0,32],"drug_indices_end":[41,11]}
{"index":2692,"text":"Halogenated anesthetics form liver adducts and antigens that cross-react with halothane-induced antibodies.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["halothane"],"drug_indices_start":[78],"drug_indices_end":[87]}
{"index":2694,"text":"Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bladder and liver tumours","bladder","liver tumours"],"disease_indices_start":[28,40],"disease_indices_end":[35,53],"drugs":["paracetamol"],"drug_indices_start":[13],"drug_indices_end":[24]}
{"index":2698,"text":"Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[32],"disease_indices_end":[41],"drugs":["aryl-piperazine"],"drug_indices_start":[51],"drug_indices_end":[66]}
{"index":2700,"text":"Diazepam facilitates reflex bradycardia in conscious rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["bradycardia"],"disease_indices_start":[28],"disease_indices_end":[39],"drugs":["Diazepam"],"drug_indices_start":[0],"drug_indices_end":[8]}
{"index":2702,"text":"Chronic carbamazepine inhibits the development of local anesthetic seizures kindled by cocaine and lidocaine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[67],"disease_indices_end":[75],"drugs":["carbamazepine","cocaine","lidocaine"],"drug_indices_start":[8,99,87],"drug_indices_end":[108,21,94]}
{"index":2704,"text":"D-penicillamine in the treatment of localized scleroderma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["localized scleroderma"],"disease_indices_start":[36],"disease_indices_end":[57],"drugs":["D-penicillamine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":2706,"text":"Preservation of renal blood flow during hypotension induced with fenoldopam in dogs.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypotension"],"disease_indices_start":[40],"disease_indices_end":[51],"drugs":["fenoldopam"],"drug_indices_start":[65],"drug_indices_end":[75]}
{"index":2708,"text":"Antiarrhythmic effects of optical isomers of cibenzoline on canine ventricular arrhythmias.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular arrhythmias"],"disease_indices_start":[67],"disease_indices_end":[90],"drugs":["cibenzoline"],"drug_indices_start":[45],"drug_indices_end":[56]}
{"index":2710,"text":"Effect of Hibiscus rosa sinensis on reserpine-induced neurobehavioral and biochemical alterations in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Hibiscus rosa sinensis","reserpine"],"drug_indices_start":[10,36],"drug_indices_end":[32,45]}
{"index":2712,"text":"Comparison of aqueous and gellan ophthalmic timolol with placebo on the 24-hour heart rate response in patients on treatment for glaucoma.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glaucoma"],"disease_indices_start":[129],"disease_indices_end":[137],"drugs":["timolol"],"drug_indices_start":[44],"drug_indices_end":[51]}
{"index":2714,"text":"5 flourouracil-induced apical ballooning syndrome: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["apical ballooning syndrome"],"disease_indices_start":[23],"disease_indices_end":[49],"drugs":["5 flourouracil"],"drug_indices_start":[0],"drug_indices_end":[14]}
{"index":2716,"text":"Reduction of pain during induction with target-controlled propofol and remifentanil.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[13],"disease_indices_end":[17],"drugs":["propofol","remifentanil"],"drug_indices_start":[58,71],"drug_indices_end":[66,83]}
{"index":2718,"text":"Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["fetal pulmonary hypertension","fetal pulmonary hypertension","pulmonary hypertension"],"disease_indices_start":[40,46],"disease_indices_end":[68],"drugs":["fluoxetine"],"drug_indices_start":[21],"drug_indices_end":[31]}
{"index":2720,"text":"Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Syncope","QT prolongation"],"disease_indices_start":[0,12],"disease_indices_end":[7,27],"drugs":["methadone","heroin"],"drug_indices_start":[56,70],"drug_indices_end":[65,76]}
{"index":2722,"text":"Peripheral neuropathy caused by high-dose cytosine arabinoside treatment in a patient with acute myeloid leukemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Peripheral neuropathy","acute myeloid leukemia"],"disease_indices_start":[0,91],"disease_indices_end":[21,113],"drugs":["cytosine arabinoside"],"drug_indices_start":[42],"drug_indices_end":[62]}
{"index":2724,"text":"Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[58],"disease_indices_end":[70],"drugs":["Atorvastatin","dexamethasone"],"drug_indices_start":[0,36],"drug_indices_end":[49,12]}
{"index":2726,"text":"Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pain"],"disease_indices_start":[106],"disease_indices_end":[110],"drugs":["kainate"],"drug_indices_start":[43],"drug_indices_end":[50]}
{"index":2728,"text":"Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppression in renal transplant recipients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Sirolimus","mycophenolate mofetil"],"drug_indices_start":[0,14],"drug_indices_end":[9,35]}
{"index":2730,"text":"Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["anemia","cytotoxicity","tumors"],"disease_indices_start":[28,73,93],"disease_indices_end":[34,85,99],"drugs":["cyclophosphamide"],"drug_indices_start":[56],"drug_indices_end":[72]}
{"index":2732,"text":"The role of nitrergic system in lidocaine-induced convulsion in the mouse.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["convulsion"],"disease_indices_start":[50],"disease_indices_end":[60],"drugs":["lidocaine"],"drug_indices_start":[32],"drug_indices_end":[41]}
{"index":2734,"text":"Effect of intravenous metoprolol or intravenous metoprolol plus glucagon on dobutamine-induced myocardial ischemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial ischemia"],"disease_indices_start":[95],"disease_indices_end":[114],"drugs":["metoprolol","metoprolol","dobutamine"],"drug_indices_start":[48,76,22],"drug_indices_end":[32,58,86]}
{"index":2736,"text":"Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscle dysfunction","atrophy"],"disease_indices_start":[21,58],"disease_indices_end":[39,65],"drugs":["Prednisolone","acetylcholine"],"drug_indices_start":[0,82],"drug_indices_end":[12,95]}
{"index":2738,"text":"Rapid reversal of life-threatening diltiazem-induced tetany with calcium chloride.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["tetany"],"disease_indices_start":[53],"disease_indices_end":[59],"drugs":["diltiazem","calcium chloride"],"drug_indices_start":[65,35],"drug_indices_end":[81,44]}
{"index":2740,"text":"Effects of nonsteroidal anti-inflammatory drugs on hemostasis in patients with aneurysmal subarachnoid hemorrhage.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["aneurysmal subarachnoid hemorrhage"],"disease_indices_start":[79],"disease_indices_end":[113],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2742,"text":"Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated with the total dose infusion of iron dextran: a double blind randomized trial.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["arthralgia","myalgia"],"disease_indices_start":[49,60],"disease_indices_end":[59,67],"drugs":["methylprednisolone","iron dextran"],"drug_indices_start":[120,9],"drug_indices_end":[27,132]}
{"index":2744,"text":"Long-term effects of vincristine on the peripheral nervous system.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["vincristine"],"drug_indices_start":[21],"drug_indices_end":[32]}
{"index":2746,"text":"A case of polymyositis in a patient with primary biliary cirrhosis treated with D-penicillamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["polymyositis","primary biliary cirrhosis"],"disease_indices_start":[10,41],"disease_indices_end":[22,66],"drugs":["D-penicillamine"],"drug_indices_start":[80],"drug_indices_end":[95]}
{"index":2748,"text":"Photodistributed nifedipine-induced facial telangiectasia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["telangiectasia"],"disease_indices_start":[43],"disease_indices_end":[57],"drugs":["nifedipine"],"drug_indices_start":[17],"drug_indices_end":[27]}
{"index":2750,"text":"Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Nephrotoxicity"],"disease_indices_start":[0],"disease_indices_end":[14],"drugs":["cyclosporin A","FK506"],"drug_indices_start":[18,36],"drug_indices_end":[41,31]}
{"index":2752,"text":"Massive cerebral edema associated with fulminant hepatic failure in acetaminophen overdose: possible role of cranial decompression.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cerebral edema","hepatic failure","overdose"],"disease_indices_start":[8,49,82],"disease_indices_end":[22,64,90],"drugs":["acetaminophen"],"drug_indices_start":[68],"drug_indices_end":[81]}
{"index":2754,"text":"Gentamicin nephropathy in a neonate.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephropathy"],"disease_indices_start":[11],"disease_indices_end":[22],"drugs":["Gentamicin"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":2756,"text":"Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["carcinogenic"],"disease_indices_start":[5],"disease_indices_end":[17],"drugs":["phenobarbital","diethylnitrosamine"],"drug_indices_start":[28,68],"drug_indices_end":[41,86]}
{"index":2758,"text":"Post-operative rigidity after fentanyl administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rigidity"],"disease_indices_start":[15],"disease_indices_end":[23],"drugs":["fentanyl"],"drug_indices_start":[30],"drug_indices_end":[38]}
{"index":2759,"text":"A case of thoraco-abdominal rigidity leading to respiratory failure is described in the post-operative period in an elderly patient who received a moderate dose of fentanyl. This was successfully reversed by naloxone. The mechanisms possibly implicated in this accident are discussed.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["rigidity","respiratory failure"],"disease_indices_start":[83,103],"disease_indices_end":[91,122],"drugs":["fentanyl","naloxone"],"drug_indices_start":[219,263],"drug_indices_end":[227,271]}
{"index":2760,"text":"Postpartum psychosis induced by bromocriptine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["psychosis"],"disease_indices_start":[11],"disease_indices_end":[20],"drugs":["bromocriptine"],"drug_indices_start":[32],"drug_indices_end":[45]}
{"index":2762,"text":"A prospective study on the dose dependency of cardiotoxicity induced by mitomycin C.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cardiotoxicity"],"disease_indices_start":[46],"disease_indices_end":[60],"drugs":["mitomycin C"],"drug_indices_start":[72],"drug_indices_end":[83]}
{"index":2764,"text":"Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glycosuria","nephrotoxicity"],"disease_indices_start":[18,57],"disease_indices_end":[28,71],"drugs":["Phlorizin","gentamicin"],"drug_indices_start":[0,46],"drug_indices_end":[56,9]}
{"index":2766,"text":"Tiapride in levodopa-induced involuntary movements.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["involuntary movements"],"disease_indices_start":[29],"disease_indices_end":[50],"drugs":["Tiapride","levodopa"],"drug_indices_start":[0,12],"drug_indices_end":[8,20]}
{"index":2768,"text":"Effects of the hippocampal deep brain stimulation on cortical epileptic discharges in penicillin - induced epilepsy model in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["epileptic","epilepsy"],"disease_indices_start":[62,107],"disease_indices_end":[71,115],"drugs":["penicillin"],"drug_indices_start":[86],"drug_indices_end":[96]}
{"index":2770,"text":"Neural correlates of S-ketamine induced psychosis during overt continuous verbal fluency.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["psychosis"],"disease_indices_start":[40],"disease_indices_end":[49],"drugs":["S-ketamine"],"drug_indices_start":[21],"drug_indices_end":[31]}
{"index":2772,"text":"Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["neurotoxicity"],"disease_indices_start":[73],"disease_indices_end":[86],"drugs":["Dopamine","methamphetamine"],"drug_indices_start":[0,49],"drug_indices_end":[8,64]}
{"index":2774,"text":"Brainstem dysgenesis in an infant prenatally exposed to cocaine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Brainstem dysgenesis"],"disease_indices_start":[0],"disease_indices_end":[20],"drugs":["cocaine"],"drug_indices_start":[56],"drug_indices_end":[63]}
{"index":2775,"text":"Many authors described the effects on the fetus of maternal cocaine abuse during pregnancy. Vasoconstriction appears to be the common mechanism of action leading to a wide range of fetal anomalies. We report on an infant with multiple cranial-nerve involvement attributable to brainstem dysgenesis, born to a cocaine-addicted mother.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cocaine abuse","fetal anomalies","multiple cranial-nerve involvement","brainstem dysgenesis","cocaine-addicted"],"disease_indices_start":[125,246,291,342,374],"disease_indices_end":[138,261,325,362,390],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2776,"text":"The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetic nephropathy"],"disease_indices_start":[54],"disease_indices_end":[74],"drugs":["streptozotocin"],"drug_indices_start":[31],"drug_indices_end":[45]}
{"index":2778,"text":"High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["seizures"],"disease_indices_start":[66],"disease_indices_end":[74],"drugs":["tranexamic Acid"],"drug_indices_start":[10],"drug_indices_end":[25]}
{"index":2780,"text":"Recurrent dysosmia induced by pyrazinamide.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dysosmia"],"disease_indices_start":[10],"disease_indices_end":[18],"drugs":["pyrazinamide"],"drug_indices_start":[30],"drug_indices_end":[42]}
{"index":2782,"text":"Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["colorectal adenomas"],"disease_indices_start":[150],"disease_indices_end":[169],"drugs":["difluoromethylornithine","sulindac"],"drug_indices_start":[114,86],"drug_indices_end":[122,109]}
{"index":2784,"text":"Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["mental slowing"],"disease_indices_start":[10],"disease_indices_end":[24],"drugs":["trihexyphenidyl"],"drug_indices_start":[72],"drug_indices_end":[87]}
{"index":2786,"text":"Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["steroid","serotonin"],"drug_indices_start":[90,51],"drug_indices_end":[58,99]}
{"index":2788,"text":"Intracavitary chemotherapy (paclitaxel\/carboplatin liquid crystalline cubic phases) for recurrent glioblastoma -- clinical observations.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["glioblastoma"],"disease_indices_start":[98],"disease_indices_end":[110],"drugs":["paclitaxel","carboplatin"],"drug_indices_start":[28,39],"drug_indices_end":[50,38]}
{"index":2790,"text":"Methylphenidate-induced obsessive-compulsive symptoms in an elderly man.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["obsessive-compulsive symptoms"],"disease_indices_start":[24],"disease_indices_end":[53],"drugs":["Methylphenidate"],"drug_indices_start":[0],"drug_indices_end":[15]}
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{"index":2807,"text":"Forty minutes after receiving a single starting dose of trazodone, a patient developed complete heart block. The case illustrates that, despite the results of earlier studies, trazodone's effect on cardiac conduction may be severe in individuals at risk for conduction delay.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart block"],"disease_indices_start":[155],"disease_indices_end":[166],"drugs":["trazodone","trazodone"],"drug_indices_start":[115,235],"drug_indices_end":[124,244]}
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{"index":2816,"text":"Changes in peroxisomes in preneoplastic liver and hepatoma of mice induced by alpha-benzene hexachloride.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hepatoma"],"disease_indices_start":[50],"disease_indices_end":[58],"drugs":["alpha-benzene hexachloride"],"drug_indices_start":[78],"drug_indices_end":[104]}
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{"index":2820,"text":"Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Cholesteryl hemisuccinate","acetaminophen","adriamycin","carbon tetrachloride","chloroform","galactosamine"],"drug_indices_start":[0,128,106,79,143,94],"drug_indices_end":[104,138,156,25,92,126]}
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{"index":2826,"text":"Cutaneous leucocytoclastic vasculitis associated with oxacillin.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cutaneous leucocytoclastic vasculitis"],"disease_indices_start":[0],"disease_indices_end":[37],"drugs":["oxacillin"],"drug_indices_start":[54],"drug_indices_end":[63]}
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{"index":2840,"text":"Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["marrow suppression","immunodeficiency"],"disease_indices_start":[52,104],"disease_indices_end":[70,120],"drugs":["Benzylacyclouridine","azidothymidine"],"drug_indices_start":[0,29],"drug_indices_end":[43,19]}
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{"index":2844,"text":"Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hyperalgesia","myoclonus","cancer"],"disease_indices_start":[0,17,39],"disease_indices_end":[12,26,45],"drugs":["morphine"],"drug_indices_start":[91],"drug_indices_end":[99]}
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{"index":2848,"text":"Blockade of both D-1 and D-2 dopamine receptors may induce catalepsy in mice.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["catalepsy"],"disease_indices_start":[59],"disease_indices_end":[68],"drugs":["dopamine"],"drug_indices_start":[29],"drug_indices_end":[37]}
{"index":2850,"text":"Dextran-etodolac conjugates: synthesis, in vitro and in vivo evaluation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["Dextran","etodolac"],"drug_indices_start":[0,8],"drug_indices_end":[16,7]}
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{"index":2854,"text":"All- trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["erythema nodosum","acute promyelocytic leukemia"],"disease_indices_start":[33,67],"disease_indices_end":[49,95],"drugs":["All- trans-retinoic acid"],"drug_indices_start":[0],"drug_indices_end":[24]}
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{"index":2858,"text":"Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: a comparative study of the efficacy and safety against amlodipine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension"],"disease_indices_start":[74],"disease_indices_end":[86],"drugs":["Valsartan","angiotensin II","amlodipine"],"drug_indices_start":[0,17,143],"drug_indices_end":[9,153,31]}
{"index":2860,"text":"KF17837: a novel selective adenosine A2A receptor antagonist with anticataleptic activity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["KF17837","adenosine"],"drug_indices_start":[0,27],"drug_indices_end":[36,7]}
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{"index":2864,"text":"Severe congestive heart failure patient on amiodarone presenting with myxedemic coma: a case report.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["congestive heart failure","myxedemic coma","myxedemic","coma"],"disease_indices_start":[7,70,80],"disease_indices_end":[31,79,84],"drugs":["amiodarone"],"drug_indices_start":[43],"drug_indices_end":[53]}
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{"index":2870,"text":"Is phenytoin administration safe in a hypothermic child?","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypothermic"],"disease_indices_start":[38],"disease_indices_end":[49],"drugs":["phenytoin"],"drug_indices_start":[3],"drug_indices_end":[12]}
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{"index":2874,"text":"Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["aspirin","acetylsalicylic acid"],"drug_indices_start":[42,51],"drug_indices_end":[49,71]}
{"index":2876,"text":"Torsade de pointes induced by metoclopramide in an elderly woman with preexisting complete left bundle branch block.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Torsade de pointes","left bundle branch block"],"disease_indices_start":[0,91],"disease_indices_end":[18,115],"drugs":["metoclopramide"],"drug_indices_start":[30],"drug_indices_end":[44]}
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{"index":2884,"text":"Cardiac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Cardiac toxicity","angina"],"disease_indices_start":[0,68],"disease_indices_end":[16,74],"drugs":["5-fluorouracil"],"drug_indices_start":[20],"drug_indices_end":[34]}
{"index":2886,"text":"Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Toxicity","rheumatoid arthritis"],"disease_indices_start":[0,44],"disease_indices_end":[8,64],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2888,"text":"Transient hemiparesis: a rare manifestation of diphenylhydantoin toxicity. Report of two cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hemiparesis","toxicity"],"disease_indices_start":[10,65],"disease_indices_end":[21,73],"drugs":["diphenylhydantoin"],"drug_indices_start":[47],"drug_indices_end":[64]}
{"index":2890,"text":"Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["overactive bladder"],"disease_indices_start":[76],"disease_indices_end":[94],"drugs":["prostaglandins"],"drug_indices_start":[24],"drug_indices_end":[38]}
{"index":2892,"text":"Acute low back pain during intravenous administration of amiodarone: a report of two cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["low back pain"],"disease_indices_start":[6],"disease_indices_end":[19],"drugs":["amiodarone"],"drug_indices_start":[57],"drug_indices_end":[67]}
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{"index":2898,"text":"Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["vestibulotoxicity"],"disease_indices_start":[60],"disease_indices_end":[77],"drugs":["edaravone","streptomycin"],"drug_indices_start":[21,39],"drug_indices_end":[51,30]}
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{"index":2902,"text":"Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["amnesic"],"disease_indices_start":[68],"disease_indices_end":[75],"drugs":["Steroid","pregnenolone sulphate"],"drug_indices_start":[0,87],"drug_indices_end":[108,7]}
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{"index":2910,"text":"Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts of the striatum to the regulation of muscle tone in rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["glycine","NMDA"],"drug_indices_start":[20,36],"drug_indices_end":[40,27]}
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{"index":2920,"text":"Treatment of ifosfamide-induced urothelial toxicity by oral administration of sodium 2-mercaptoethane sulphonate (MESNA) to patients with inoperable lung cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["urothelial toxicity","lung cancer"],"disease_indices_start":[32,149],"disease_indices_end":[51,160],"drugs":["ifosfamide","sodium 2-mercaptoethane sulphonate","MESNA"],"drug_indices_start":[114,13,78],"drug_indices_end":[112,119,23]}
{"index":2922,"text":"Time course alterations of QTC interval due to hypaque 76.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["hypaque 76"],"drug_indices_start":[47],"drug_indices_end":[57]}
{"index":2924,"text":"Production of autochthonous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["prostate cancer"],"disease_indices_start":[28],"disease_indices_end":[43],"drugs":["N-nitroso-N-methylurea","testosterone"],"drug_indices_start":[112,85],"drug_indices_end":[107,124]}
{"index":2926,"text":"A dystonia-like syndrome after neuropeptide (MSH\/ACTH) stimulation of the rat locus ceruleus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["dystonia"],"disease_indices_start":[2],"disease_indices_end":[10],"drugs":["MSH","ACTH"],"drug_indices_start":[49,45],"drug_indices_end":[48,53]}
{"index":2928,"text":"Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["muscle rigidity"],"disease_indices_start":[87],"disease_indices_end":[102],"drugs":["Dexmedetomidine"],"drug_indices_start":[0],"drug_indices_end":[15]}
{"index":2930,"text":"Seizure activity with imipenem therapy: incidence and risk factors.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Seizure"],"disease_indices_start":[0],"disease_indices_end":[7],"drugs":["imipenem"],"drug_indices_start":[22],"drug_indices_end":[30]}
{"index":2932,"text":"The ability of insulin treatment to reverse or prevent the changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["diabetes mellitus"],"disease_indices_start":[128],"disease_indices_end":[145],"drugs":["streptozotocin"],"drug_indices_start":[105],"drug_indices_end":[119]}
{"index":2934,"text":"Delayed institution of hypertension during focal cerebral ischemia: effect on brain edema.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertension","cerebral ischemia","brain edema"],"disease_indices_start":[23,49,78],"disease_indices_end":[35,66,89],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2936,"text":"Amiodarone pulmonary toxicity.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["pulmonary toxicity"],"disease_indices_start":[11],"disease_indices_end":[29],"drugs":["Amiodarone"],"drug_indices_start":[0],"drug_indices_end":[10]}
{"index":2938,"text":"Light chain proteinuria and cellular mediated immunity in rifampin treated patients with tuberculosis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria","tuberculosis"],"disease_indices_start":[12,89],"disease_indices_end":[23,101],"drugs":["rifampin"],"drug_indices_start":[58],"drug_indices_end":[66]}
{"index":2940,"text":"Initial potassium loss and hypokalaemia during chlorthalidone administration in patients with essential hypertension: the influence of dietary sodium restriction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypokalaemia","hypertension"],"disease_indices_start":[27,104],"disease_indices_end":[39,116],"drugs":["potassium","chlorthalidone","sodium"],"drug_indices_start":[8,143,47],"drug_indices_end":[17,61,149]}
{"index":2942,"text":"Dynamic response of blood vessel in acute renal failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute renal failure"],"disease_indices_start":[36],"disease_indices_end":[55],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2944,"text":"The hemodynamics of oxytocin and other vasoactive agents during neuraxial anesthesia for cesarean delivery: findings in six cases.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["oxytocin"],"drug_indices_start":[20],"drug_indices_end":[28]}
{"index":2946,"text":"Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-\/-) mice with cyclophosphamide (CYP)-induced cystitis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cystitis"],"disease_indices_start":[145],"disease_indices_end":[153],"drugs":["cyclophosphamide","CYP"],"drug_indices_start":[114,132],"drug_indices_end":[130,135]}
{"index":2948,"text":"Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["uveitis"],"disease_indices_start":[38],"disease_indices_end":[45],"drugs":["fluocinolone acetonide"],"drug_indices_start":[59],"drug_indices_end":[81]}
{"index":2952,"text":"Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["myocardial infarction"],"disease_indices_start":[58],"disease_indices_end":[79],"drugs":["Dexatrim","Phenylpropanolamine"],"drug_indices_start":[13,23],"drug_indices_end":[42,21]}
{"index":2954,"text":"Risperidone-associated, benign transient visual disturbances in schizophrenic patients with a past history of LSD abuse.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["visual disturbances","schizophrenic"],"disease_indices_start":[41,64],"disease_indices_end":[60,77],"drugs":["Risperidone","LSD"],"drug_indices_start":[0,110],"drug_indices_end":[113,11]}
{"index":2956,"text":"Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["heart failure"],"disease_indices_start":[92],"disease_indices_end":[105],"drugs":["poly(ADP-ribose)","doxorubicin"],"drug_indices_start":[72,14],"drug_indices_end":[83,30]}
{"index":2958,"text":"Fluconazole-induced torsade de pointes.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["torsade de pointes"],"disease_indices_start":[20],"disease_indices_end":[38],"drugs":["Fluconazole"],"drug_indices_start":[0],"drug_indices_end":[11]}
{"index":2960,"text":"High-dose methylprednisolone may do more harm for spinal cord injury.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["spinal cord injury"],"disease_indices_start":[50],"disease_indices_end":[68],"drugs":["methylprednisolone"],"drug_indices_start":[10],"drug_indices_end":[28]}
{"index":2964,"text":"Acetazolamide-induced Gerstmann syndrome.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Gerstmann syndrome"],"disease_indices_start":[22],"disease_indices_end":[40],"drugs":["Acetazolamide"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2965,"text":"Acute confusion induced by acetazolamide is a well known adverse drug reaction in patients with renal impairment. We report a case of acetazolamide-induced Gerstmann syndrome in a patient with normal renal function, to highlight predisposing factors that are frequently overlooked.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["confusion","renal impairment","Gerstmann syndrome"],"disease_indices_start":[48,138,198],"disease_indices_end":[57,154,216],"drugs":["acetazolamide","acetazolamide"],"drug_indices_start":[176,69],"drug_indices_end":[82,189]}
{"index":2966,"text":"Hypomania-like syndrome induced by olanzapine.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Hypomania"],"disease_indices_start":[0],"disease_indices_end":[9],"drugs":["olanzapine"],"drug_indices_start":[35],"drug_indices_end":[45]}
{"index":2967,"text":"We report a female patient with a diagnosis of a not otherwise specified psychotic disorder (DSM-IV) who developed hypomania shortly after the introduction of olanzapine treatment.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["psychotic disorder","hypomania"],"disease_indices_start":[120,162],"disease_indices_end":[138,171],"drugs":["olanzapine"],"drug_indices_start":[206],"drug_indices_end":[216]}
{"index":2968,"text":"Neutrophil superoxide and hydrogen peroxide production in patients with acute liver failure.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["acute liver failure"],"disease_indices_start":[72],"disease_indices_end":[91],"drugs":["superoxide","hydrogen peroxide"],"drug_indices_start":[26,11],"drug_indices_end":[43,21]}
{"index":2970,"text":"Absence of effect of sertraline on time-based sensitization of cognitive impairment with haloperidol.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cognitive impairment"],"disease_indices_start":[63],"disease_indices_end":[83],"drugs":["sertraline","haloperidol"],"drug_indices_start":[89,21],"drug_indices_end":[100,31]}
{"index":2972,"text":"Ciprofloxacin-induced nephrotoxicity in patients with cancer.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["nephrotoxicity","cancer"],"disease_indices_start":[22,54],"disease_indices_end":[36,60],"drugs":["Ciprofloxacin"],"drug_indices_start":[0],"drug_indices_end":[13]}
{"index":2974,"text":"Case report: pentamidine and polymorphic ventricular tachycardia revisited.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["ventricular tachycardia"],"disease_indices_start":[41],"disease_indices_end":[64],"drugs":["pentamidine"],"drug_indices_start":[13],"drug_indices_end":[24]}
{"index":2976,"text":"Time dependence of plasma malondialdehyde, oxypurines, and nucleosides during incomplete cerebral ischemia in the rat.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cerebral ischemia"],"disease_indices_start":[89],"disease_indices_end":[106],"drugs":["malondialdehyde","oxypurines","nucleosides"],"drug_indices_start":[59,26,43],"drug_indices_end":[41,53,70]}
{"index":2978,"text":"Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["toxicity"],"disease_indices_start":[12],"disease_indices_end":[20],"drugs":["echothiophate iodide"],"drug_indices_start":[59],"drug_indices_end":[79]}
{"index":2980,"text":"Acute renal failure in high dose carboplatin chemotherapy.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Acute renal failure"],"disease_indices_start":[0],"disease_indices_end":[19],"drugs":["carboplatin"],"drug_indices_start":[33],"drug_indices_end":[44]}
{"index":2982,"text":"Endometrial carcinoma after Hodgkin disease in childhood.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Endometrial carcinoma","Hodgkin disease"],"disease_indices_start":[0,28],"disease_indices_end":[21,43],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2984,"text":"Induction of the obstructive sleep apnea syndrome in a woman by exogenous androgen administration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["obstructive sleep apnea syndrome"],"disease_indices_start":[17],"disease_indices_end":[49],"drugs":["androgen"],"drug_indices_start":[74],"drug_indices_end":[82]}
{"index":2986,"text":"Effect of captopril on pre-existing and aminonucleoside-induced proteinuria in spontaneously hypertensive rats.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["proteinuria","hypertensive"],"disease_indices_start":[64,93],"disease_indices_end":[75,105],"drugs":["captopril","aminonucleoside"],"drug_indices_start":[40,10],"drug_indices_end":[19,55]}
{"index":2988,"text":"Epileptogenic properties of enflurane and their clinical interpretation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["enflurane"],"drug_indices_start":[28],"drug_indices_end":[37]}
{"index":2990,"text":"Reversible cerebral lesions associated with tiazofurin usage: MR demonstration.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["cerebral lesions"],"disease_indices_start":[11],"disease_indices_end":[27],"drugs":["tiazofurin"],"drug_indices_start":[44],"drug_indices_end":[54]}
{"index":2992,"text":"Antagonism of diazepam-induced sedative effects by Ro15-1788 in patients after surgery under lumbar epidural block. A double-blind placebo-controlled investigation of efficacy and safety.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":null,"disease_indices_start":null,"disease_indices_end":null,"drugs":["diazepam","Ro15-1788"],"drug_indices_start":[51,14],"drug_indices_end":[60,22]}
{"index":2994,"text":"Enhanced stimulus-induced neurotransmitter overflow in epinephrine-induced hypertensive rats is not mediated by prejunctional beta-adrenoceptor activation.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["hypertensive"],"disease_indices_start":[75],"disease_indices_end":[87],"drugs":["epinephrine"],"drug_indices_start":[55],"drug_indices_end":[66]}
{"index":2996,"text":"Ocular manifestations of juvenile rheumatoid arthritis.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["juvenile rheumatoid arthritis"],"disease_indices_start":[25],"disease_indices_end":[54],"drugs":null,"drug_indices_start":null,"drug_indices_end":null}
{"index":2998,"text":"Water intoxication associated with oxytocin administration during saline-induced abortion.","gene":null,"gene_indices_start":null,"gene_indices_end":null,"disease":["Water intoxication","abortion"],"disease_indices_start":[0,81],"disease_indices_end":[18,89],"drugs":["oxytocin"],"drug_indices_start":[35],"drug_indices_end":[43]}