0 0 0 , -2.99261 ) -3.42303 . -3.5763 H -3.89817 ; -4.02483 - -4.07866 ▁( -4.08451 ▁and -4.09389 ▁was -4.30235 ▁with -4.34818 ▁ADD -4.35528 ▁mmol -4.37525 ), -4.46317 ▁g -4.47365 ▁mL -4.50433 ▁1 -4.69469 ); -4.7488 ▁of -4.79462 ▁the -4.80708 ▁mg -4.83544 ▁for -4.87434 ▁to -4.96289 ▁at -4.97243 ▁in -4.99229 2 -5.02401 ▁The -5.0449 ). -5.12669 ▁a -5.19804 ▁ml -5.26045 ▁C -5.27448 yl -5.29586 ▁2 -5.33528 ▁mixture -5.41297 ▁solution -5.41728 m -5.48404 3 -5.49956 -2- -5.51262 d -5.5475 ▁added -5.55215 ▁acid -5.584 ▁ -5.59817 ▁M -5.60336 ▁STIR -5.63403 ] -5.63868 ▁J -5.66982 ▁water -5.69126 D -5.7135 s -5.74672 ▁temperature -5.75519 methyl -5.75615 ▁Hz -5.77236 ▁Y -5.79041 SOLUTION -5.79268 AKE -5.79271 ▁SLN -5.79272 IEL -5.79303 ▁over -5.83408 ▁compound -5.84392 ▁CONCENTRATE -5.87239 -4- -5.8976 ▁stirred -5.90828 ACTION -5.92266 ▁NO -5.92271 ▁by -5.92722 / -5.92765 ▁3 -5.93031 ▁room -5.94858 ▁ethyl -5.95587 -3- -5.96328 ▁sodium -5.98023 ▁title -5.98338 N -6.00312 4 -6.01157 ▁reaction -6.01729 ▁WAS -6.03388 ▁acetate -6.03806 -1- -6.04612 : -6.04779 ▁(1 -6.09598 ▁under -6.10043 ▁as -6.12063 ▁h -6.13626 ▁hours -6.1725 L -6.18709 ▁N -6.21251 ▁organic -6.22665 phenyl -6.22825 M -6.23484 )- -6.2612 ( -6.30624 ▁m -6.31524 ▁aqueous -6.32857 C -6.34553 ▁were -6.38238 amino -6.38243 ▁chloride -6.39434 ▁concentrated -6.39487 ▁(2 -6.39652 ▁H -6.42219 ▁dried -6.44922 ▁then -6.4605 ▁solid -6.46881 S -6.48483 ▁residue -6.49343 ▁FILTER -6.50744 UTION -6.50923 ▁DRYSOL -6.50954 ▁is -6.51219 ▁washed -6.52253 chloro -6.5289 -5- -6.53233 ▁PURIFY -6.53391 ▁purified -6.53924 butyl -6.55162 + -6.57462 ▁To -6.58169 ▁yield -6.59592 ▁give -6.60912 ▁min -6.62304 ▁(10 -6.63587 ▁2- -6.64402 ethyl -6.65408 ▁product -6.66788 ▁4 -6.66844 ▁δ -6.6829 ▁chromatography -6.68479 R -6.68834 ▁brine -6.6897 5 -6.69754 ▁0° -6.70013 1 -6.70807 ▁A -6.71734 -1 -6.71786 ▁(5 -6.7362 ▁THF -6.74014 ▁filtrate -6.75073 O -6.75484 ▁NMR -6.75798 ▁4- -6.77689 6 -6.78979 ▁filtered -6.79137 ACT -6.80249 ▁EXTR -6.80254 ER -6.81429 ▁keep -6.81638 AY -6.81638 ECT -6.81644 ▁COLL -6.81682 ▁minutes -6.82902 ▁5 -6.83158 ▁EtOAc -6.84364 ▁(50 -6.85491 ▁saturated -6.85601 t -6.87106 ▁dichloromethane -6.87353 ▁(100 -6.87499 ▁sulfate -6.88001 ▁(20 -6.89011 ▁ether -6.89142 bromo -6.89816 8 -6.92127 ▁silica -6.92218 ▁30 -6.93306 ▁MHz -6.93893 7 -6.93946 ▁(3 -6.94155 ▁gel -6.94454 ▁methyl -6.95431 ▁extracted -6.96087 ▁methanol -6.96796 z -6.97812 ▁After -6.97911 TEM -6.98866 URE -6.98912 PERAT -6.98917 SET -6.98918 methoxy -6.99483 9 -6.99772 fluoro -7.00072 ▁10 -7.01216 ▁mol -7.02707 0 -7.03534 Cl -7.03695 ▁ester -7.03738 ▁tert -7.04278 ▁pressure -7.04622 a -7.04623 ▁column -7.0545 hydroxy -7.06499 ▁dissolved -7.08659 ▁reduced -7.09241 carboxylate -7.09513 ▁oil -7.0974 -6- -7.09742 ▁3- -7.09948 ▁s -7.1061 one -7.11297 ▁= -7.1364 tert -7.14271 ▁heated -7.14885 b -7.15334 ▁DMF -7.15389 ▁overnight -7.15979 dihydro -7.16328 carboxylic -7.16538 dimethyl -7.16627 pyridin -7.16743 oxo -7.18485 ▁MS -7.19062 ▁DCM -7.19334 ▁an -7.1936 ▁cooled -7.19935 ▁carbonate -7.20588 ▁resulting -7.20831 ▁6 -7.22642 ▁HCl -7.23484 SO -7.23497 ▁Na -7.23624 ▁layer -7.23921 ▁d -7.25251 ▁[ -7.25255 ▁crude -7.27408 ▁CH -7.28177 ▁solvent -7.2866 ▁dropwise -7.2875 trifluoromethyl -7.29671 ▁vacuo -7.30899 )-2- -7.31818 ▁tetrahydrofuran -7.32272 ▁evaporated -7.33056 ▁15 -7.33248 [ -7.34636 ▁afford -7.35674 ▁20 -7.35688 ▁(30 -7.35895 ▁ethanol -7.36767 ▁from -7.36908 ▁eq -7.3715 ▁(4 -7.38085 ▁combined -7.38243 ▁potassium -7.39835 amine -7.4041 ▁(400 -7.42544 ▁on -7.42619 ▁5- -7.42639 ▁Example -7.43798 ▁white -7.44383 tetrahydro -7.44673 ▁hour -7.45039 ▁yellow -7.4706 dd -7.48171 ▁obtained -7.48175 ▁hydroxide -7.48411 pyridine -7.48625 ]- -7.49138 ▁μ -7.50296 ▁nitrogen -7.50819 ▁16 -7.51717 ▁MeOH -7.53972 ▁(200 -7.54533 ▁using -7.55559 ▁hydrochloride -7.55632 ▁magnesium -7.57736 ▁x -7.58852 ▁1- -7.59312 ▁stirring -7.60248 ▁diluted -7.60616 ▁anhydrous -7.6119 ▁toluene -7.61341 } -7.61428 )-1 -7.62164 ): -7.63062 ▁hydrochloric -7.63182 4; -7.63772 c -7.64107 ▁° -7.64673 ▁triethylamine -7.64836 pyrimidin -7.67556 ▁which -7.67717 ▁precipitate -7.68307 ▁(15 -7.68544 ▁hr -7.69204 ▁followed -7.69613 ▁removed -7.69935 )-3- -7.70169 ▁(300 -7.70239 ▁REFLUX -7.7118 e -7.71509 ▁vacuum -7.74738 ▁phase -7.75016 ▁DMSO -7.75314 imethylformamide -7.75993 ▁diethyl -7.76199 -7- -7.76299 -2 -7.77385 benzyl -7.78466 ▁pH -7.78937 MS -7.79927 ▁MgSO -7.7994 ▁prepared -7.8021 ▁desired -7.8057 oxy -7.80593 ▁(6 -7.8068 3) -7.81499 ▁NaHCO -7.83547 ▁equiv -7.8402 ▁9 -7.85533 ▁8 -7.86639 ▁(25 -7.86664 carbonyl -7.86754 ▁treated -7.87695 ▁hydrogen -7.8776 ▁18 -7.87785 ▁CDCl -7.8785 ▁acetonitrile -7.87932 ▁(40 -7.88543 ▁- -7.89414 CO -7.89644 ▁acetic -7.89701 ▁(500 -7.89981 propyl -7.90884 ▁RT -7.91366 )-4- -7.92031 ▁6- -7.9433 ▁1.5 -7.94521 ▁methylene -7.94721 ▁bicarbonate -7.94794 ▁off -7.95212 ▁50 -7.95394 ▁ice -7.96446 g -7.96721 ▁flash -7.97282 ▁normal -7.97317 ▁suspension -7.97843 ▁molar -7.97886 ESI -7.98112 ol -7.98749 ethoxy -7.98907 PROCEDURE -7.98907 ▁ambient -7.98913 OTHER -7.98915 ▁FO -7.98925 LOW -7.98928 ▁(1.0 -7.98973 ▁HPLC -7.99297 br -7.9955 ▁hexane -7.99877 piperidine -8.00623 ▁rt -8.01449 ▁unknown -8.02113 [2,3- -8.03843 ▁t -8.04393 ▁100 -8.05173 hexane -8.05339 ▁(150 -8.05791 nitro -8.0765 ▁reflux -8.07675 piperidin -8.07696 ▁12 -8.08656 ▁LCMS -8.10035 pyrazol -8.10289 fluorophenyl -8.10539 ▁L -8.10771 benzo -8.11167 ▁described -8.11324 CDCl -8.11981 ▁(0.5 -8.12019 ▁dry -8.12321 ▁7 -8.1244 ▁NaOH -8.13304 ▁1.0 -8.1382 ▁chloroform -8.14806 ▁addition -8.15195 IT -8.1529 pyrimidine -8.15323 )-1- -8.1539 ▁WA -8.15689 ▁80° -8.1601 ▁obtain -8.1658 ▁dioxane -8.1675 ▁are -8.16776 ▁filtration -8.16858 ▁into -8.17087 p -8.17089 6) -8.17246 ▁layers -8.18235 ▁hydride -8.18715 l -8.19564 methanol -8.19989 pyrrolo -8.20181 NMR -8.2043 ▁PH -8.20892 carboxamide -8.21047 ▁further -8.22288 ▁0.5 -8.2271 benzyloxy -8.23065 bis -8.23069 ▁atmosphere -8.2332 ▁LC -8.23455 ▁ammonium -8.23946 ▁ppm -8.24377 benzoic -8.24454 E -8.25079 ▁24 -8.25496 )-5- -8.25768 ▁Pd -8.26232 ▁eluting -8.26381 ▁40 -8.2702 cyclopropyl -8.27182 4, -8.27912 NCH -8.28018 ▁NH -8.2875 ▁allowed -8.2887 dichloro -8.28985 -1,3- -8.29313 ▁100° -8.29702 QUE -8.29895 CH -8.301 ▁through -8.30235 ▁collected -8.30917 ▁separated -8.31073 butoxycarbonyl -8.31369 ▁(60 -8.3153 ▁−78° -8.31572 ▁argon -8.31996 ▁(8 -8.3201 ▁pyridine -8.32573 (1 -8.33644 ▁(1.5 -8.34197 ▁60° -8.34278 cyano -8.34556 ▁TFA -8.34782 ▁PHASESEPARATION -8.34844 acetic -8.35342 ▁n -8.36204 ▁10% -8.36344 ▁procedure -8.36352 dimethylamino -8.36355 ▁50° -8.37166 difluoro -8.37335 -8- -8.37661 ▁material -8.37706 phenoxy -8.39701 ▁K -8.40291 Hz -8.40414 DMSO -8.42394 ▁cooling -8.42495 ‌ -8.43266 ▁colorless -8.43437 carbamate -8.43635 ▁quenched -8.44228 tetramethyl -8.44293 indol -8.44564 phenylphosphine -8.45371 ▁bromide -8.45683 ▁(2.0 -8.47038 ▁Et -8.47492 ▁1,4- -8.47711 ▁gradient -8.47996 ▁flask -8.48626 ▁iodide -8.48686 ▁lithium -8.48917 pyrazolo -8.48984 chlorophenyl -8.4919 ▁hexanes -8.49194 benzene -8.49674 ▁0 -8.49821 ▁poured -8.49848 ▁step -8.50116 tri -8.51256 -( -8.51587 ▁14 -8.51664 imidazo -8.51687 biphenyl -8.5191 ▁25 -8.52145 ▁mole -8.52839 %). -8.52978 [1,2- -8.53115 ▁this -8.5358 indole -8.53599 ▁palladium -8.53656 ▁2.5 -8.5392 ▁acetone -8.54146 ▁found -8.54177 ▁provide -8.54834 dioxane -8.55352 methoxyphenyl -8.56282 ▁bath -8.56332 acetate -8.56403 ▁aq -8.57431 iodo -8.57987 ▁(7 -8.58177 ▁mmole -8.58267 pyrrolidine -8.58283 ▁(80 -8.58698 ▁(250 -8.5907 imidazol -8.59247 sulfonyl -8.59641 isopropyl -8.5997 ▁used -8.60903 ylmethyl -8.61815 acetamide -8.6222 ▁purification -8.62548 yloxy -8.62869 dione -8.63106 pyran -8.63188 )-6- -8.63235 -5 -8.63404 ▁that -8.63419 pyrrolidin -8.63688 piperazine -8.63718 ▁EtOH -8.63928 pyrazole -8.64123 }- -8.64243 di -8.64709 cyclohexyl -8.65575 ▁2-( -8.65584 ▁di -8.65967 ▁gave -8.66713 A -8.66745 ES -8.67048 % -8.6721 n -8.6754 ▁13 -8.67686 ▁brown -8.68103 thiazol -8.68352 acetyl -8.68434 ▁B -8.68763 ▁p -8.68943 ▁carbon -8.69094 ▁45 -8.69152 [3,4- -8.69462 ▁dryness -8.70218 ]+ -8.70288 ▁This -8.70954 ▁slowly -8.70963 carbonitrile -8.71185 ▁7- -8.71304 ▁60 -8.71442 ▁2.0 -8.7172 ▁benzyl -8.72098 ▁(2.5 -8.72578 ing -8.72847 -1,2- -8.7297 -2,3- -8.73429 [1,5- -8.74238 piperazin -8.74475 ▁refluxed -8.74499 ▁11 -8.75082 II -8.75409 )+. -8.7544 ]+. -8.7556 q -8.7593 ▁after -8.76068 ▁Water -8.76286 ▁trifluoroacetic -8.7659 ▁extracts -8.76601 ▁distilled -8.77304 ,4 -8.7744 ▁anhydride -8.77616 en -8.77998 ,5 -8.78285 ▁dimethyl -8.78777 ▁90° -8.79666 -4-( -8.79891 = -8.8024 palladium -8.80318 ]-2- -8.80335 amide -8.80547 ▁(5.0 -8.80722 Na -8.80884 -(4- -8.80914 ▁µ -8.81216 ▁4-( -8.81608 o -8.81666 ▁(12 -8.81971 (2 -8.82237 ▁25° -8.82413 ▁70° -8.8322 ▁(75 -8.8322 ▁(9 -8.83273 ▁containing -8.83329 ▁salt -8.83358 ▁tri -8.83459 ▁time -8.83506 ' -8.83855 sulfonamide -8.84018 trifluoro -8.84227 ▁In -8.8433 ▁pale -8.84905 ▁1.2 -8.8521 F -8.85369 ▁Then -8.85386 ▁mp -8.85531 quinolin -8.85893 EtOAc -8.85898 benzaldehyde -8.86245 benzoate -8.8634 ▁powder -8.86397 3): -8.86654 I -8.86729 benzonitrile -8.86787 ▁200 -8.86851 ▁diisopropyl -8.87302 ▁TRIT -8.87345 -(2- -8.8735 URATE -8.87376 -1,4- -8.87417 benzamide -8.87835 ▁(70 -8.87849 [3,2- -8.88036 ▁between -8.88811 ▁same -8.89148 -2-( -8.89214 ▁17 -8.89242 ▁according -8.89459 hydroxymethyl -8.89569 ▁preparative -8.9008 Chloro -8.90571 18 -8.90702 quinoline -8.91232 ▁48 -8.92191 ylamino -8.92309 +) -8.92833 ▁sulphate -8.9327 ▁light -8.93495 ▁DRYSOLID -8.94317 ▁about -8.94584 ▁up -8.94938 ▁crystals -8.95393 dimethoxy -8.95469 ▁acidic -8.95872 ▁(1.2 -8.96232 ▁days -8.96297 ▁Step -8.96315 ▁times -8.96415 ic -8.96849 TI -8.97177 ed -8.97534 -4 -8.97543 )-2-( -8.98085 ▁% -8.98227 thiophene -8.9867 ▁400 -8.98794 water -8.98797 [4,5- -8.99003 ▁PAR -8.99108 TION -8.9917 ▁0.1 -8.99542 f -8.9957 ▁(0.2 -8.99745 ▁(0.1 -8.99745 MeOH -8.99771 ethylamine -8.99885 ▁without -8.99997 ▁Yield -9.00214 -1,3,2- -9.00242 ▁one -9.0052 boronic -9.00708 ▁sat -9.0077 ▁Sodium -9.01219 ▁thereto -9.01273 ▁partitioned -9.01408 ▁(3.0 -9.02189 ▁DIPEA -9.02197 ▁1.00 -9.02528 ▁starting -9.02646 -3-( -9.02684 -3,4- -9.0269 methylphenyl -9.02862 ▁microwave -9.03559 dioxaborolan -9.03578 ▁40° -9.0372 ▁2-(4- -9.03862 propan -9.03873 mol -9.03942 ▁bis -9.04468 hexanes -9.04607 Bromo -9.04623 pyrido -9.04651 ▁Purification -9.05062 ▁dd -9.0564 carbamoyl -9.05748 ▁warmed -9.05782 ▁5% -9.05788 ▁suspended -9.06128 ▁TLC -9.06219 v -9.06658 ′- -9.06727 ▁3-( -9.06841 ▁charged -9.06898 silica -9.07662 ▁1.1 -9.07743 ▁afforded -9.08152 ▁eluent -9.084 ▁(120 -9.08546 ▁additional -9.08589 ▁phases -9.08619 propionic -9.08785 ▁method -9.09241 ▁Ethyl -9.09832 trimethylsilyl -9.09848 ▁via -9.10494 benzoyl -9.10551 ml -9.10987 CN -9.11209 ▁acidified -9.11277 ▁300 -9.11288 ethanol -9.11313 ▁fractions -9.11316 ]-3- -9.11523 ▁120° -9.11741 [4,3- -9.1184 ▁twice -9.11842 -(3- -9.121 ▁resultant -9.12156 MgSO -9.1238 ▁ammonia -9.1262 ethanone -9.12803 ▁manner -9.12897 ▁ESI -9.12957 triazol -9.13352 ▁(35 -9.13488 benzofuran -9.13655 pyrazin -9.13655 -9- -9.13685 nitrophenyl -9.14349 ▁it -9.14444 ▁three -9.14507 h -9.15017 ▁liquid -9.1584 ▁/ -9.15982 20 -9.16257 ▁example -9.16493 ][1,4] -9.16582 %) -9.16784 ▁Intermediate -9.16793 α -9.16825 ▁alcohol -9.17135 ▁cm -9.17359 imidazole -9.1756 ▁1,2- -9.179 Z -9.18171 ene -9.18243 ▁warm -9.18252 ▁19 -9.18373 pyridyl -9.19025 ▁until -9.19377 P -9.19831 ▁calcd -9.19931 OH -9.19933 ▁above -9.20156 ▁Found -9.20233 ▁50% -9.203 B -9.20889 ▁80 -9.20972 (4- -9.21015 dioxo -9.21058 ▁cesium -9.2182 -5-( -9.21875 ▁stir -9.22372 methylsulfonyl -9.22855 ▁taken -9.23231 ▁(1.1 -9.23342 J -9.24317 carbamic -9.24409 ▁150 -9.25081 white -9.25203 ▁extract -9.2542 carbaldehyde -9.25436 ]-4- -9.25439 ▁round -9.25838 ▁4-(4- -9.26039 − -9.26317 -3 -9.2634 ▁0.2 -9.26876 ▁triturated -9.2727 OD -9.27388 ▁evaporation -9.27536 -2,4- -9.27642 ▁90 -9.27736 aR -9.28125 ▁mm -9.28126 (2- -9.28184 ▁borohydride -9.2849 )-3-( -9.28647 naphthalen -9.29119 ▁HATU -9.29418 -1,2,4- -9.29698 Example -9.29896 yield -9.29913 ▁(0.3 -9.30072 ▁1-(4- -9.30087 ▁500 -9.30122 ▁next -9.30209 MH -9.30347 ▁8- -9.30354 cyclopentyl -9.30566 ▁monohydrate -9.30688 ▁1.6 -9.31097 ▁3.0 -9.3125 methoxybenzyl -9.31598 +). -9.31696 ▁: -9.31871 formyl -9.32216 ▁benzene -9.32259 mmol -9.3307 ▁two -9.33361 carbodiimide -9.33542 ]-1 -9.33586 ▁(4.0 -9.33622 ▁Compound -9.33785 ▁completion -9.33786 methylene -9.33888 thiazole -9.33974 ▁following -9.33983 ▁0.25 -9.34221 Amino -9.34235 ▁portion -9.34385 diamine -9.34434 6, -9.34824 ▁20° -9.34921 Butyl -9.34977 ▁copper -9.35045 mg -9.35127 ▁(90 -9.35465 ▁110° -9.35491 methylthio -9.35616 )-7- -9.35658 ▁(45 -9.35798 mL -9.35879 ▁Ar -9.35897 ▁D -9.36059 (3 -9.36108 ▁mixed -9.36185 ▁(600 -9.36268 bs -9.36349 thio -9.36409 difluorophenyl -9.36422 prop -9.36532 cyclohexane -9.36683 6): -9.36825 ▁(1.6 -9.3702 ▁2-(2- -9.37111 ▁3.5 -9.37511 10 -9.37814 =8.4 -9.38084 quinazolin -9.38272 triazolo -9.38521 cyclopropane -9.38539 ▁complete -9.38839 trimethyl -9.38914 ▁S -9.39077 thiophen -9.39344 aniline -9.39487 bromomethyl -9.39602 ▁Celite -9.39791 ▁chromatographed -9.39936 4. -9.4007 -2(1 -9.40077 in -9.40449 ▁br -9.40949 ▁35 -9.41009 phenol -9.41226 pyrazine -9.41521 ▁mass -9.41524 ▁heptane -9.41688 ▁Rt -9.41803 ▁similar -9.4215 ▁sealed -9.42214 vinyl -9.42362 indazol -9.4238 ▁1-( -9.42566 ,6 -9.4266 ▁(0.25 -9.42681 -6 -9.42743 spiro -9.43457 — -9.43457 furan -9.43631 morpholin -9.43688 ▁R -9.43733 ▁(1.3 -9.43935 ▁pure -9.44243 ▁100% -9.44253 ppm -9.44414 ▁NaH -9.44558 =8.0 -9.44583 15 -9.44908 25 -9.45321 ▁TEA -9.45351 ▁(11 -9.45373 propanol -9.45421 -2-(4- -9.45513 19 -9.45634 ▁cool -9.45807 ▁portions -9.46234 ▁(0.15 -9.46319 ▁(10.0 -9.46348 ▁isolated -9.46376 ▁solids -9.4643 heptane -9.4654 4), -9.46673 DCM -9.4672 ▁2,4- -9.46776 ▁reverse -9.47103 min -9.47141 =7.2 -9.47189 pyrrole -9.47284 ▁intermediate -9.47434 ▁r -9.47456 ▁3-(4- -9.47608 ▁before -9.47636 ▁tR -9.48081 ▁(16 -9.48118 diisopropylethyl -9.4814 propanoate -9.48247 methanone -9.48265 -1,2,3,4- -9.48287 butoxy -9.4847 17 -9.48476 ▁tetrakis -9.48643 butoxide -9.487 thieno -9.48814 isoquinoline -9.48906 -4,5- -9.49108 ▁hrs -9.49451 i -9.49674 ▁2,6- -9.49772 ▁celite -9.49851 ▁4-(2- -9.49873 ▁1.3 -9.50048 aS -9.50159 ▁amine -9.50187 ▁70 -9.50276 ▁Methyl -9.50317 bromophenyl -9.50407 ▁(1.00 -9.50427 ▁NaCl -9.50528 pyridazin -9.50857 ▁(18 -9.50953 ▁adjusted -9.51035 benzenesulfonyl -9.51324 acetone -9.5145 ▁(0.4 -9.51611 but -9.51686 ▁1-(3- -9.52216 ▁gas -9.52348 -1-( -9.53066 ▁grams -9.53243 ▁vial -9.53695 isoquinolin -9.5406 ▁0.3 -9.54063 ▁sulfuric -9.54152 )-4-( -9.54387 methoxycarbonyl -9.54405 ▁chloroformate -9.54408 ▁thionyl -9.54591 ▁isopropyl -9.54594 ▁DIEA -9.54873 hexahydro -9.54975 ▁2.4 -9.55012 DEGAS -9.55019 ▁purity -9.55024 ▁tube -9.55084 dichlorophenyl -9.55105 x -9.55179 hydroxyphenyl -9.5526 acetonitrile -9.55356 ▁(14 -9.5552 -2,6- -9.55662 iphenylphosphino -9.55666 ▁cold -9.55718 ▁orange -9.56128 ▁1.4 -9.5617 propoxy -9.56237 ▁250 -9.56289 ▁trans -9.56427 +1). -9.56544 16 -9.56553 β -9.56572 ly -9.5662 ▁continued -9.56713 ▁1-(2- -9.57123 ▁(1.4 -9.57152 (0) -9.57512 Methyl -9.57691 ▁Rf -9.57784 ▁0.15 -9.57867 Intermediate -9.57975 trans -9.58153 ▁while -9.58186 methanesulfonyl -9.58291 ▁eluted -9.58389 oxa -9.58454 ▁tetra -9.58499 PPh -9.58577 ▁CHCl -9.58605 ▁21 -9.58798 hydroxyethyl -9.588 ▁foam -9.59035 4) -9.59179 2( -9.59329 chloromethyl -9.59407 ▁(4- -9.59426 methylamino -9.59518 ▁20% -9.59545 ▁5.0 -9.59818 ▁filter -9.59837 ▁O -9.60132 ▁2-(3- -9.60169 ▁neutral -9.60174 ▁remove -9.60196 trifluoromethoxy -9.60442 ▁general -9.60451 )-1-( -9.61055 ▁(0.6 -9.61268 ▁1.8 -9.61332 ate -9.61346 ▁4.0 -9.61381 aminomethyl -9.61477 oxadiazol -9.61661 ▁5° -9.62059 ▁-78° -9.63171 ▁hydrazine -9.63283 ZE -9.63903 ▁RE -9.63908 21 -9.64098 ▁36 -9.64151 ▁mineral -9.64277 CRYSTALLI -9.64359 ▁hydrate -9.64483 ▁complex -9.64995 ▁heating -9.6511 )-1,3- -9.65121 30 -9.65478 ▁75 -9.65491 =8.8 -9.65796 -(5- -9.65829 ▁clear -9.65849 ▁2.2 -9.66249 ▁synthesized -9.66735 -7 -9.669 14 -9.66999 ▁amount -9.67006 ▁30% -9.67365 ▁0.4 -9.67397 benzotriazole -9.67501 6- -9.68033 ▁successively -9.68096 ▁(3.5 -9.68126 ▁0.6 -9.682 ▁citric -9.68281 ▁formed -9.68426 ▁(1.8 -9.68585 ▁(13 -9.68838 ▁1:1 -9.6893 propane -9.68941 ▁mM -9.69425 =8 -9.6956 ▁phenyl -9.69719 ▁E -9.70163 ▁pad -9.70407 ▁22 -9.70502 ▁Mass -9.70587 ▁0.05 -9.70603 -3,5- -9.70702 -4-(4- -9.71211 ▁4.5 -9.71314 hydride -9.71477 naphthalene -9.71533 indazole -9.71762 ▁trifluoro -9.71881 13 -9.7192 ▁LiOH -9.71942 ▁period -9.71949 ethoxycarbonyl -9.72188 ]-1- -9.72255 ▁60% -9.72498 -6-( -9.72546 ▁0.12 -9.72661 ▁3,5- -9.72737 cyclopenta -9.72752 -3-(3- -9.72766 ▁1,1- -9.72776 ▁point -9.72808 ▁placed -9.72966 =2 -9.73002 ▁solvents -9.73297 ▁7.5 -9.73368 ▁aluminum -9.73549 ]-5- -9.73552 ▁(0.8 -9.73617 ▁MeCN -9.73746 11 -9.73775 ▁0.22 -9.73969 dppf -9.74013 azetidin -9.74018 ▁calculated -9.74182 ▁1.7 -9.74348 ▁2.1 -9.74409 ▁basic -9.74478 methanesulfonate -9.74556 eluent -9.74579 2.1 -9.74713 ▁(110 -9.74793 ▁spectrum -9.74996 ▁drop -9.75014 Method -9.75079 ▁petroleum -9.75223 ▁kg -9.75246 ▁150° -9.75529 ▁drying -9.75597 ▁NaBH -9.75668 y -9.75712 ▁catalyst -9.75725 =7.6 -9.75737 HPLC -9.75897 )-5-( -9.76023 ▁volume -9.76064 ▁65° -9.76177 ▁(24 -9.76182 ethynyl -9.76221 ▁(55 -9.76292 ylamine -9.76611 ▁(0.20 -9.76911 ▁isopropanol -9.77064 ▁(6.0 -9.77082 ▁0.20 -9.77449 ▁Following -9.77461 ▁3,4- -9.77586 ▁(4.5 -9.77642 oxazol -9.77659 pyrrol -9.7783 tetrahydrofuran -9.7789 diphenyl -9.77907 ,7 -9.77916 -3-(4- -9.78032 ▁(65 -9.78083 ▁(2.2 -9.78092 ▁(17 -9.78237 ▁[( -9.78248 ▁P -9.7886 '- -9.7903 ▁triacetoxyboro -9.79219 ▁dihydrochloride -9.79267 +): -9.79392 ydrogencarbonate -9.79467 -1,6- -9.79633 ▁120 -9.797 -1(2 -9.79718 ▁0.24 -9.79743 -9 -9.79748 ▁1,3- -9.79772 ▁phosphate -9.79835 butanol -9.79864 ▁(0.50 -9.79881 ▁2,2- -9.79967 ▁5-( -9.8028 ▁0.11 -9.80293 methane -9.80466 ▁0.33 -9.80469 ▁base -9.80787 ▁(130 -9.80859 2.0 -9.80873 26 -9.8109 ▁oxalyl -9.81185 -5,6,7,8- -9.81275 ▁0.14 -9.81381 ▁analogous -9.81514 cyclobutyl -9.81981 ▁organics -9.82178 al -9.82259 ▁neutralized -9.82416 cooling -9.82521 ▁+ -9.82987 )-2,3- -9.83152 ▁0.36 -9.83256 ® -9.83318 ▁0.35 -9.83552 ▁10.0 -9.83583 ▁26 -9.83638 ▁oily -9.83661 urea -9.83761 1.1 -9.83782 =7.5 -9.83828 butylammonium -9.83884 morpholine -9.84004 prepared -9.84017 ▁fluoride -9.84082 ▁0.30 -9.84172 ▁55 -9.84217 12 -9.84222 ▁0.18 -9.84293 ▁ES -9.8435 azabicyclo -9.84393 dichloromethane -9.84425 OAc -9.84477 ▁DMAP -9.84534 nitrobenzene -9.84567 ▁(1.7 -9.84686 dihydroxy -9.8479 ▁8.0 -9.84852 ▁28 -9.84852 ▁drops -9.8505 ▁0.8 -9.85113 [4.5] -9.8523 pyridazine -9.85275 ▁CD -9.85332 ▁0.45 -9.85551 =4 -9.85697 ▁hexa -9.85754 -2,5- -9.8576 ▁%). -9.85839 bicyclo -9.8585 ▁3-(2- -9.85879 ▁(160 -9.85887 ▁T -9.85982 /1 -9.86035 tetrazol -9.8612 ▁moles -9.86192 9.1 -9.86206 ▁again -9.86387 ▁0.23 -9.8639 ▁v -9.86437 RS -9.86465 ▁0.10 -9.86488 =7.8 -9.86656 ▁I -9.86714 -2-(2- -9.86736 ▁23 -9.86794 =7.0 -9.86827 oxide -9.86867 ▁0.32 -9.86932 ▁72 -9.86956 ▁parts -9.8706 2.2 -9.87142 ▁4-(3- -9.87238 quinazoline -9.87363 ▁re -9.8749 ▁2.3 -9.87534 ▁0.28 -9.87577 furo -9.87645 ▁out -9.87866 ▁It -9.87931 ▁be -9.88049 ▁azide -9.88074 ▁mmoles -9.88077 ▁0.34 -9.8814 ▁100%). -9.88248 ▁0.16 -9.88416 ferrocene -9.88433 ▁zinc -9.88492 =8.5 -9.88508 ▁0.1% -9.88574 ▁Method -9.88804 27 -9.88854 ▁44 -9.88945 ▁directly -9.89054 ▁0.50 -9.89079 =3 -9.89086 ▁1.25 -9.89197 ▁(350 -9.89324 phenylamino -9.89439 ▁glacial -9.89563 ▁cyclohexane -9.89615 er -9.89658 ▁(140 -9.89749 ▁high -9.89845 ▁38 -9.8992 morpholino -9.89996 ▁0.13 -9.89999 butyllithium -9.90075 ▁Calcd -9.90257 8.1 -9.90293 ▁42 -9.90414 )-2,2- -9.90428 ▁(0.05 -9.90484 ▁0.26 -9.90919 ▁(180 -9.90964 on -9.9113 5.1 -9.9117 ▁HRMS -9.91182 ▁extraction -9.912 -1,2,3- -9.91458 ▁85° -9.91481 3.1 -9.91501 6.1 -9.91546 ▁(0.7 -9.91623 ▁concentration -9.91667 ▁slurry -9.91677 ▁l -9.91734 ▁0.27 -9.91771 ▁(0.30 -9.91914 methylpyridin -9.9195 pentyl -9.92072 4.1 -9.92087 ▁(800 -9.92159 acetamido -9.92182 triazin -9.92249 ▁2,3- -9.92253 -(1- -9.92323 -6,7- -9.92357 to -9.92517 ▁27 -9.92599 ▁(0.16 -9.92652 7.1 -9.92676 2,3,4,5- -9.92681 ▁49 -9.92729 ▁(2.1 -9.92857 5.0 -9.92959 SiO -9.93176 ▁0.38 -9.93216 ▁(0.12 -9.93511 )-3,4- -9.93616 ▁(125 -9.93661 -4-(2- -9.93701 ▁formic -9.9381 ▁(2.4 -9.939 ▁0.21 -9.9411 ▁46 -9.94114 ▁0.75 -9.94131 Fluoro -9.94272 dt -9.94289 )-2-(4- -9.94304 28 -9.94362 ▁39 -9.94473 ddd -9.94506 ▁(19 -9.94555 [2,1- -9.94686 ▁(60% -9.94715 diethyl -9.94754 ▁sulfoxide -9.94762 aza -9.95059 dibromo -9.95161 -1-(4- -9.95373 -[1,2,4] -9.9582 ▁down -9.95882 benzimidazol -9.95952 =6.8 -9.96051 ▁rotary -9.96126 ▁7.2 -9.96231 ▁2.00 -9.96236 tolyl -9.9634 ▁calc -9.96424 ▁AcOH -9.96451 ▁EA -9.96497 ▁0.29 -9.96608 ▁(21 -9.96653 ▁0.40 -9.96825 24 -9.96856 ▁(2- -9.97126 =7 -9.97318 ▁10° -9.97474 propanoic -9.97498 fluorobenzyl -9.97572 ▁precipitated -9.97648 onto -9.9767 ▁130° -9.97974 ▁being -9.98227 ▁1.9 -9.98239 ▁8.4 -9.98305 ▁0.44 -9.98353 ▁(28 -9.98668 ▁0.31 -9.9868 dimethylethyl -9.9871 ▁(22 -9.9879 ▁1.50 -9.9887 isoxazol -9.98904 =7.1 -9.98981 oxoethyl -9.99028 r -9.99073 ▁another -9.99083 dimethoxyphenyl -9.99347 ▁methanesulfonyl -9.99368 PO -9.99409 ▁2.6 -9.99464 ▁thus -9.99464 ▁(23 -9.99517 ▁0.19 -9.99551 ▁excess -9.99631 methanesulfonic -9.99642 ▁adding -9.99773 ▁0.43 -9.99831 ▁(0.22 -9.99842 =2.0 -9.99846 piperidinyl -9.99907 ▁29 -10.0005 ▁(0.10 -10.0016 ▁(0.23 -10.0019 oxazole -10.0055 ▁HOBt -10.008 ▁47 -10.0086 (3- -10.0097 azetidine -10.0113 ▁0.42 -10.0125 ▁system -10.0126 )-1-(4- -10.0128 3)4 -10.0135 ▁6.0 -10.0139 ▁0.48 -10.0139 50 -10.0145 ylcarbamate -10.0151 3° -10.0159 ▁equivalents -10.0161 ▁37 -10.0171 triazole -10.0172 ▁sequentially -10.0175 ▁(0.24 -10.0182 ▁(2.00 -10.019 1.0 -10.0198 w -10.02 ▁colourless -10.0202 naphthyridin -10.0219 ▁7.0 -10.0226 ▁31 -10.0237 ▁43 -10.0238 ▁piperidine -10.0251 )-8- -10.0256 ▁0.17 -10.0263 ▁equipped -10.0266 u -10.0282 ▁vessel -10.0282 T -10.0283 ▁(0.17 -10.0283 =8.2 -10.0284 ▁F -10.029 butyldimethylsil -10.0304 ▁EDC -10.033 ▁(0.35 -10.0332 ▁0.37 -10.034 ▁provided -10.0345 phenylboronic -10.0347 ▁(2.3 -10.0347 ine -10.0351 ▁(5.5 -10.0353 ▁dark -10.0361 ▁elution -10.0368 ▁methoxide -10.0408 0.1 -10.0412 ▁0.02 -10.0429 ▁(36 -10.0436 ▁0.55 -10.0469 =8.1 -10.0472 butyric -10.049 MHz -10.0507 ▁(7.5 -10.051 8.2 -10.0515 ▁cis -10.0526 3.2 -10.0529 ▁cartridge -10.0538 carboxy -10.0546 =8.3 -10.055 =8.6 -10.0556 ▁2.7 -10.0569 1.2 -10.0577 pyridinyl -10.0582 – -10.0588 octane -10.0607 ▁(85 -10.0607 ▁nm -10.0608 tetra -10.0633 ethane -10.0639 ▁isocyanate -10.0645 allyl -10.0651 acetoxy -10.0657 -2,2- -10.0659 ▁0.46 -10.0672 29 -10.0673 ▁(1.9 -10.0683 ▁(0.28 -10.0687 ▁(0.21 -10.0692 8° -10.0696 ▁dicarbonate -10.0712 -5,6- -10.0719 ▁0.39 -10.074 Hydroxy -10.0744 9.2 -10.0766 ▁1.05 -10.0766 diazabicyclo -10.077 ▁(0.18 -10.0785 ▁(0.14 -10.0797 ▁small -10.08 ▁(0.26 -10.0803 ▁(42 -10.081 Boc -10.0814 ▁uL -10.082 ][1,3] -10.0824 ▁morpholine -10.0826 methoxymethyl -10.0834 ▁(27 -10.0841 ▁2.8 -10.0842 ▁cyanide -10.0848 =8.7 -10.0851 dicarboxylate -10.0852 ▁(48 -10.0854 ▁5.5 -10.086 ▁yielding -10.087 ▁(32 -10.0874 )-3-(4- -10.088 3.0 -10.0896 =5 -10.0901 ▁51 -10.0902 =7.3 -10.0915 ▁0.41 -10.0923 ▁(26 -10.0929 CD -10.0932 }-2- -10.0947 ethylamino -10.0959 methylsulfanyl -10.0985 ▁34 -10.0996 ▁8.8 -10.1001 toluene -10.1003 enyl -10.1005 ▁33 -10.1017 ▁bottom -10.1025 8.0 -10.1028 dichloroethane -10.1064 ▁amide -10.1073 ▁(700 -10.1075 ▁Cs -10.1078 ▁1.20 -10.1082 ▁IR -10.1086 ▁oxide -10.109 ▁tris -10.1099 ▁53 -10.1102 ▁0.65 -10.1114 ▁(2.6 -10.1115 ₂ -10.1117 ▁65 -10.1121 -3-(2- -10.1121 ▁3-(3- -10.1125 ▁(0.19 -10.1127 ▁distillation -10.1132 ▁Triethylamine -10.1134 imino -10.1144 methanamine -10.1179 )— -10.1182 ▁preparation -10.1184 ▁showed -10.1208 ▁nitrite -10.1216 benzimidazole -10.1216 ▁KOH -10.1224 ▁prep -10.123 purin -10.1231 ar -10.1233 ▁(46 -10.1236 ▁Potassium -10.1237 35 -10.1242 ▁40% -10.1246 brs -10.1247 ▁crystalline -10.125 ,11 -10.1257 ▁recrystallized -10.1265 ▁0.47 -10.127 petroleum -10.1272 fluorophosphate -10.1286 ▁3.6 -10.1294 ▁140° -10.1313 azodicarboxylate -10.1327 ▁75° -10.1337 ▁41 -10.1354 ▁(44 -10.1359 methylethyl -10.1365 naphthyl -10.1369 23 -10.1374 ▁(0.13 -10.1377 ▁52 -10.1377 ▁(0.11 -10.1409 4.0 -10.1409 ▁Preparation -10.1428 thienyl -10.1429 ▁7.6 -10.1432 ▁analysis -10.1446 thiadiazol -10.1456 ▁or -10.1472 -1-(2- -10.1473 40 -10.1474 ▁Under -10.1477 ▁(2.8 -10.1478 ▁PdCl -10.1481 ▁(38 -10.1487 ▁5-(4- -10.1491 7.2 -10.1496 ▁(0.45 -10.1498 mercapto -10.1508 ▁conditions -10.152 ▁DME -10.1524 ▁2,2,2- -10.1551 ▁0.9 -10.1561 ▁7.8 -10.1573 70 -10.1579 ▁(0.27 -10.16 ▁concentrate -10.1601 ▁(0.32 -10.1607 2° -10.164 ▁(3.2 -10.1654 ▁0.7 -10.1664 hydrazine -10.1668 ▁retention -10.1672 6.0 -10.1708 ▁peroxide -10.1712 ▁acetyl -10.1718 ▁reactor -10.1719 )+: -10.1726 ▁3.00 -10.174 ▁30° -10.1742 ]-6- -10.1744 nicotinic -10.1748 ▁3.2 -10.1757 ▁45° -10.1763 toluenesulfonic -10.1769 8.3 -10.179 ▁(0.33 -10.1817 ▁(47 -10.182 ▁54 -10.1853 ▁110 -10.1854 ▁0.52 -10.1855 NO -10.187 ▁yielded -10.1872 ▁Anal -10.1891 ▁(0.9 -10.1915 (1- -10.1916 diol -10.1924 methylmorpholine -10.1925 ▁NMP -10.1936 ▁0.54 -10.1937 =7.4 -10.1944 ▁Boc -10.1949 magnesium -10.1952 aq -10.1956 2.3 -10.1958 iso -10.1961 ▁4.8 -10.1962 ▁0.88 -10.1963 ▁(5.6 -10.1974 dec -10.1978 ▁56 -10.1986 ▁conc -10.1987 ▁0.56 -10.1987 ▁phosphorus -10.2019 phosphine -10.2049 ▁(170 -10.2049 ▁7.29 -10.2051 5.2 -10.2059 =6.6 -10.2059 ▁7.50 -10.2065 silyl -10.2084 ▁2-(5- -10.209 ▁0.60 -10.2112 ▁once -10.2112 difluoromethyl -10.2121 ▁(56 -10.2126 carbonylamino -10.2137 ▁degassed -10.2152 ▁q -10.2159 ▁(8.0 -10.2167 inden -10.2178 ▁(6.5 -10.2186 ethoxymethyl -10.22 dibenzylidene -10.22 sulfonic -10.2202 ▁0.49 -10.2215 EI -10.2217 ▁(2.7 -10.2218 ▁(5.00 -10.2226 δ -10.224 ▁0.03 -10.2242 ▁(0.40 -10.2244 ▁hydroxylamine -10.2245 ▁7.32 -10.2251 ▁0.01 -10.227 6.2 -10.23 4.2 -10.23 ▁8.5 -10.2303 ▁32 -10.2307 ▁(0.36 -10.2316 ▁(43 -10.2317 80 -10.234 an -10.2353 =9 -10.2362 7° -10.2363 4.5 -10.237 sulfamoyl -10.2371 ylidene -10.2373 ylmethoxy -10.2375 =6 -10.239 * -10.2403 ▁An -10.2403 ▁triethyl -10.2419 aminophenyl -10.242 ▁7.40 -10.2423 ▁AcOEt -10.2435 ▁−10° -10.2444 -2-(3- -10.2456 ▁boron -10.2463 ▁99%) -10.2468 ▁washing -10.2477 ▁more -10.2482 ▁0.57 -10.2487 ▁2,5- -10.2497 dioxolan -10.25 isoxazole -10.2505 naphthyridine -10.2507 ▁7.35 -10.2508 butan -10.2516 ▁(0.29 -10.2529 isopropoxy -10.253 hexyl -10.2533 Methoxy -10.2536 chloride -10.2538 chloroform -10.2546 fluoropyridin -10.2553 pent -10.2553 ▁volatiles -10.2558 ▁1.10 -10.2558 ▁7.20 -10.2565 ▁(95 -10.2572 ecrystallization -10.2575 ▁(220 -10.2586 Compound -10.2587 THF -10.26 ▁(58 -10.2606 ▁Reference -10.2608 7.0 -10.2609 ▁3.3 -10.2612 =6.0 -10.2618 ▁0.06 -10.2623 ▁(54 -10.2627 ▁7.30 -10.2633 ▁(0.75 -10.2634 ▁G -10.2643 ▁(0.34 -10.2651 ▁6.5 -10.2671 ▁air -10.2699 ▁b -10.2749 ▁0.04 -10.2757 )-6-( -10.2761 isobutyl -10.2765 ▁(64 -10.2773 ▁0.53 -10.278 ▁0.58 -10.2793 ▁7.1 -10.2801 cyanophenyl -10.2802 oxazolidin -10.2829 ▁58 -10.283 9.0 -10.2837 ammonium -10.2838 ▁7.3 -10.2838 ▁(20.0 -10.2851 dipalladium -10.2855 ▁At -10.2861 ▁10.5 -10.2874 ▁(68 -10.2892 -5-(4- -10.2897 ▁(3- -10.2901 ▁(66 -10.2903 ▁(33 -10.2904 ▁purged -10.2908 chlorobenzyl -10.2909 ▁cake -10.2917 -10 -10.2928 ▁7.42 -10.2929 ▁0.66 -10.2932 ▁7.28 -10.2941 ▁Add -10.2951 )-2-(2- -10.2953 ▁trimethyl -10.2957 propionate -10.2959 HCl -10.2968 =9.0 -10.2969 ▁57 -10.2972 ▁(5.2 -10.2975 ▁(0.38 -10.2989 -5-(2- -10.299 -1,1- -10.2993 ▁saline -10.2998 =2.4 -10.3001 ▁1.45 -10.3007 ethanamine -10.3014 ▁Using -10.3015 ▁1.44 -10.3018 ▁c -10.3039 ▁(5.4 -10.3045 ▁had -10.3048 ▁tan -10.3052 ][1,2,4] -10.3054 ▁wt -10.3065 or -10.3088 ▁subsequently -10.3089 ▁7.45 -10.3092 ▁(72 -10.3094 ▁(450 -10.3106 ▁funnel -10.3108 ▁1.15 -10.3121 ▁affording -10.313 ▁7.18 -10.3135 ▁95% -10.3136 ▁7.37 -10.3137 ▁7.4 -10.3138 ▁left -10.3141 ▁0.72 -10.3156 ▁vigorously -10.3156 ▁7.34 -10.3159 ▁chloro -10.3162 ▁portionwise -10.3165 ▁1.35 -10.3176 ▁(3.3 -10.3184 ▁analogy -10.3191 dihydrobenzo -10.3194 ▁(0.31 -10.3203 ▁each -10.3203 ▁%) -10.3211 ▁7.36 -10.3212 ▁(31 -10.3214 2.4 -10.3221 ▁55° -10.3233 )-3 -10.3242 4.3 -10.3247 ▁(49 -10.3249 ▁(0.42 -10.3257 ▁red -10.3264 bromosuccinimide -10.3264 ▁oxychloride -10.3265 -4-(3- -10.3266 ▁(57 -10.3268 ▁0.90 -10.3274 ▁(3.6 -10.3283 =6.9 -10.3284 ium -10.3287 ▁removal -10.3296 ▁0.51 -10.3298 ▁0.63 -10.3306 cyanoborohydride -10.3313 ▁4.2 -10.3319 ▁(41 -10.3324 ▁0.64 -10.3327 1.3 -10.3328 ,13 -10.3336 ▁0.85 -10.3338 ▁(4.2 -10.3345 isoindol -10.3352 ▁6.8 -10.336 ▁7.44 -10.3369 ▁oven -10.3371 ▁dichloride -10.3374 ▁0.08 -10.3376 ▁(4.6 -10.3378 ▁cyclopropyl -10.3384 ▁(76 -10.3392 ▁7.33 -10.3403 ▁0.78 -10.3405 ▁(7.0 -10.3409 ▁amorphous -10.3416 ▁rinsed -10.3417 ▁iodomethane -10.3425 ▁1.26 -10.3431 ▁equivalent -10.3434 methyloxy -10.3438 3)2 -10.344 ▁carried -10.344 trifluoroacetate -10.3441 31 -10.3448 ▁7.48 -10.3462 ▁0.68 -10.3465 ▁3.9 -10.3472 ▁0.94 -10.3473 37 -10.3484 ▁hot -10.3489 ▁8.1 -10.3491 1.8 -10.3494 ▁9- -10.3496 4° -10.35 ▁15% -10.3504 -4,6- -10.3504 ▁imidazole -10.351 ▁25% -10.3518 -(6- -10.3519 ▁0.92 -10.3522 ▁theory -10.3525 ▁methylamine -10.3552 ▁7.39 -10.3558 cis -10.3571 ▁3.1 -10.3585 Br -10.3589 ▁residual -10.3598 ▁(78 -10.36 ▁(34 -10.3602 {[ -10.3605 ▁4.6 -10.3614 methylpiperazin -10.3614 -(7- -10.3619 ▁7.55 -10.3632 ▁6-( -10.3633 5° -10.3637 APCI -10.3637 ▁23° -10.3642 =7.9 -10.3647 ▁0.80 -10.3657 ▁Reaction -10.3658 phenylsulfonyl -10.366 methylpropyl -10.366 ▁(240 -10.3661 -8 -10.3663 ▁(0.37 -10.3675 ▁EDCI -10.3678 methylpiperidin -10.368 ▁7.38 -10.3686 acetylamino -10.3686 ▁(53 -10.3689 =6.4 -10.3691 ▁(51 -10.3692 ▁0.87 -10.3695 ▁7.21 -10.37 ▁0.62 -10.3706 ▁Di -10.3711 ▁0.95 -10.3716 1.7 -10.3717 sulfanyl -10.3719 ether -10.3722 ▁insoluble -10.3738 ▁1.28 -10.3744 ▁bromine -10.3747 ▁(62 -10.375 ▁1.38 -10.3752 phosphonium -10.3757 ▁charcoal -10.3764 phenylethyl -10.377 ▁0.84 -10.377 ▁6.6 -10.3778 ▁0.86 -10.3778 ▁7.41 -10.378 3.3 -10.379 ▁DMA -10.3802 ▁0.89 -10.3804 ▁Procedure -10.381 ▁7.22 -10.3811 ▁0-5° -10.3817 ▁ion -10.3819 ▁dilute -10.3829 ▁(29 -10.3833 -10- -10.3833 ▁below -10.3838 ▁-78 -10.3838 quinoxaline -10.3841 ▁3.8 -10.3848 =1.8 -10.3857 chloropyridin -10.3859 oct -10.3872 ▁Chem -10.3876 ▁1.46 -10.3879 ▁4-(5- -10.3887 ▁Methanol -10.3895 ▁7.53 -10.3905 ▁(4.8 -10.3905 ▁1,1′- -10.3916 ▁2.9 -10.3917 ▁1.30 -10.3924 aminoethyl -10.3936 bi -10.3937 ▁5-(2- -10.3939 yn -10.3942 indan -10.3948 ▁substance -10.3953 ▁dispersion -10.3964 ▁3.4 -10.3974 ▁(52 -10.3977 pentanoic -10.398 azido -10.3991 ▁rac -10.3994 =7.7 -10.4005 ▁(4.4 -10.4007 ▁1.27 -10.4008 ▁(1.25 -10.4013 ▁w -10.4015 ′ -10.4023 Dimethyl -10.4023 ▁7.24 -10.4024 dimethylsilyloxy -10.4024 ▁4.4 -10.4025 6.3 -10.4027 6.6 -10.4033 ▁7.31 -10.405 ▁0.93 -10.4052 tetrahydropyran -10.4054 ▁reagent -10.4064 ▁7.26 -10.4067 ▁7.58 -10.4069 ▁(37 -10.4072 ▁90%). -10.4072 ▁0.61 -10.4076 ▁iron -10.4081 ▁4.00 -10.4101 ▁85 -10.4102 ▁General -10.4106 ▁0.67 -10.4106 ynyl -10.4116 ▁rate -10.4119 ▁Upon -10.4133 ▁7.25 -10.4135 method -10.4135 diisopropyl -10.4137 =4.8 -10.4145 6° -10.4149 ▁α -10.415 ▁7.46 -10.4151 ▁ACN -10.4156 ▁95° -10.4164 td -10.4167 thia -10.4169 ▁7.27 -10.4182 ▁SiO -10.4196 ▁7.54 -10.4199 dicyclohexyl -10.4202 ▁1.32 -10.4203 ▁7.65 -10.4204 ▁Saturated -10.4218 X -10.4221 0.2 -10.4226 ▁0.76 -10.4228 ▁7.60 -10.4229 ▁7.19 -10.4236 ▁No -10.4237 ▁melting -10.4243 ▁tribromide -10.4245 )-2-(( -10.4246 ▁indicated -10.4252 diamino -10.4255 ▁1.42 -10.4258 ▁gum -10.4258 4.6 -10.4258 dicarboxylic -10.4273 chroman -10.4283 ▁(1:1) -10.429 ▁giving -10.4298 [3.2.1] -10.43 ▁(2×50 -10.4306 ▁glycol -10.4319 ▁7.52 -10.4321 butane -10.4324 ▁95 -10.4324 -3(2 -10.4326 ▁(0.55 -10.4333 ▁(77 -10.4336 ▁7.10 -10.4346 ▁(73 -10.435 decane -10.4356 ▁(67 -10.4357 ▁0.59 -10.4358 ▁evaporator -10.4359 ▁0.74 -10.4363 ide -10.4366 ▁1.40 -10.4369 ▁allyl -10.437 ▁(1.05 -10.4377 ▁7.15 -10.4385 ▁−20° -10.4386 oxazin -10.4392 diaza -10.4394 id -10.4414 ▁(63 -10.4427 ▁(3.4 -10.4429 ▁9.0 -10.444 ▁(0.48 -10.4441 ▁basified -10.4448 ▁1.24 -10.445 ▁materials -10.445 trifluoroethyl -10.4453 ▁iso -10.4462 ▁0.98 -10.4466 ▁(84 -10.4468 2.9 -10.4469 compound -10.4471 uronium -10.4475 ▁3.75 -10.4481 ▁Spectrum -10.449 ▁bar -10.4494 ▁7.43 -10.4496 ▁0.91 -10.4508 as -10.451 ureido -10.4511 ▁90% -10.4531 ▁(3.8 -10.4534 (7- -10.4536 ▁0.96 -10.4541 ▁0.70 -10.4546 1.4 -10.4547 Aldrich -10.4563 ▁1.37 -10.4564 ▁0.82 -10.4566 ▁1.48 -10.457 )-5 -10.4572 V -10.4582 → -10.4589 ▁2.25 -10.4593 ▁8.7 -10.4606 ▁1.43 -10.4608 azaspiro -10.4615 difluoromethoxy -10.4618 ▁7.62 -10.4618 hex -10.4623 )-4,5- -10.4628 ▁(3.1 -10.4637 ▁10.4 -10.4645 ▁steps -10.4656 45 -10.4657 7.9 -10.4658 ′, -10.4659 ▁1.36 -10.4662 ▁7.16 -10.4663 ▁(74 -10.4668 ▁5.2 -10.467 ▁− -10.4671 ▁Flash -10.468 purine -10.4716 ▁7.80 -10.4722 ▁suction -10.4724 ▁remaining -10.4726 ▁8.6 -10.4729 2.8 -10.4733 ▁80% -10.4734 (4 -10.4744 ▁8.3 -10.4755 propanamide -10.476 ▁(0.44 -10.4762 ▁pentane -10.4765 ▁0.69 -10.4765 ▁free -10.4766 4.4 -10.4771 2.5 -10.4778 Dichloro -10.4778 ▁(0.65 -10.4783 ▁1.47 -10.4784 octahydro -10.4785 ▁(61 -10.4785 90 -10.4785 ▁7.47 -10.4789 9.3 -10.4794 acrylate -10.4795 ▁0.81 -10.4797 ▁2.50 -10.48 carboxamido -10.4801 ▁5.6 -10.4803 ▁7.70 -10.4805 ▁(5.3 -10.4812 -1,5- -10.4826 ▁1.23 -10.4827 ▁X -10.4833 ▁0.07 -10.4836 ▁7.63 -10.4837 ▁7.75 -10.4838 imethylsulfoxide -10.4839 methoxypyridin -10.4844 dioxaborolane -10.4845 1.6 -10.4856 ▁1.22 -10.4856 ▁thiosulfate -10.4857 ▁(0.43 -10.4862 ▁(1000 -10.4863 triphenyl -10.4867 ▁trimethylsilyl -10.4894 ▁1.33 -10.4897 ▁(0.46 -10.49 ▁0.09 -10.4902 ▁6.9 -10.4909 ▁7.51 -10.4913 ▁(1.50 -10.4927 ▁(0.39 -10.493 7.3 -10.4932 ▁0.73 -10.4932 ▁formate -10.4937 -3,3- -10.494 6.5 -10.495 ▁observed -10.495 thiazolo -10.4962 ▁1.08 -10.4983 ▁ca -10.499 ▁(3×50 -10.4992 ▁1.29 -10.4993 0% -10.4994 ▁7.49 -10.4994 cyclohex -10.4997 7.5 -10.4998 }-1 -10.5013 ▁3.7 -10.5013 ▁during -10.5021 ▁85%) -10.5022 phenylamine -10.5029 ▁1.75 -10.5034 )+, -10.5034 ▁several -10.5042 ▁MTBE -10.5044 3.5 -10.5059 ▁(5.8 -10.506 ▁absolute -10.506 ▁1.18 -10.5067 ▁(15.0 -10.5068 ▁1-(5- -10.5068 )-1,2,3,4- -10.5076 ▁1.39 -10.5077 ▁isomer -10.5082 benzothiazol -10.5084 ▁i -10.509 ▁(96 -10.5091 ▁8.2 -10.5093 diazaspiro -10.5095 ▁magnetic -10.5099 [5,4- -10.5103 )-1-(2- -10.5111 7.8 -10.5113 1.5 -10.5114 ▁(3.00 -10.5115 ▁(210 -10.512 ▁(59 -10.5123 3.9 -10.5124 8.4 -10.5125 ▁(0.41 -10.5135 ▁(39 -10.5135 carboxaldehyde -10.5137 ▁80%). -10.5151 ▁instead -10.5156 ▁7.57 -10.5163 5.3 -10.5164 ▁fraction -10.5168 ▁stirrer -10.5174 ▁syringe -10.518 (3,3- -10.5181 ▁0.83 -10.5183 hept -10.5184 PE -10.5184 acrylic -10.5186 ▁(6.3 -10.519 )-7 -10.5193 -[(1 -10.5199 ▁64 -10.5199 ▁(50% -10.5202 hydroxypropyl -10.5211 ▁95%). -10.5212 phenethyl -10.5212 dioxide -10.5221 ▁7.56 -10.5225 mycomp -10.5228 ▁carefully -10.523 example -10.5234 ▁7.9 -10.5235 undec -10.5235 ▁benzoyl -10.5238 ▁(10% -10.5239 ▁12.0 -10.5242 ▁(230 -10.5243 60 -10.5243 ▁1.17 -10.525 ▁7.7 -10.5253 ▁0.77 -10.5253 methoxyethoxy -10.5258 ▁0.97 -10.5267 ▁1.34 -10.5267 aminopropyl -10.5275 ▁get -10.5286 phosphino -10.5287 4.9 -10.529 ▁available -10.5291 ▁1.06 -10.5293 ▁1.16 -10.5295 (2,3- -10.5304 ▁10.6 -10.5305 ▁7.00 -10.5308 ▁(190 -10.5326 dimethylphenyl -10.533 ▁condenser -10.5333 ▁(69 -10.5334 ▁7.78 -10.5335 methylpyridine -10.5335 ▁7.68 -10.5339 ▁7.59 -10.5342 ▁tetrachloride -10.5344 diimidazole -10.535 -[( -10.5351 ClN -10.5355 ▁(82 -10.536 ▁(86 -10.5363 ▁ArH -10.5371 ▁3.85 -10.5371 it -10.5372 ▁7.13 -10.5385 ▁7.64 -10.5387 ▁ethylene -10.5389 )-3-(2- -10.5393 ▁7.12 -10.5394 )-4 -10.5397 ▁10.3 -10.5399 ▁7.23 -10.5404 trimethylsilanyl -10.5404 pyrimido -10.5413 bR -10.5416 ▁7.61 -10.5421 3.4 -10.543 )-2 -10.5432 piperazinyl -10.545 K -10.5451 ▁1.14 -10.5452 ▁eluant -10.5461 ▁(0.60 -10.5462 =1.5 -10.5464 6.9 -10.5473 :1 -10.5476 5.4 -10.5479 ▁0.71 -10.5479 ▁5.4 -10.548 )-4-(4- -10.5482 ▁(88 -10.5484 ▁1.04 -10.5489 [1,4] -10.5493 ▁(750 -10.5508 ▁(71 -10.5511 ▁Aqueous -10.5521 ▁4.3 -10.5524 ▁(4.7 -10.5525 ▁LRMS -10.5529 ▁7.05 -10.553 ▁1.41 -10.5532 ▁94%) -10.5533 ▁(2.9 -10.5536 ▁Biotage -10.5537 ▁(270 -10.5538 ▁1.02 -10.5543 cyclopentane -10.5549 ▁7.17 -10.5551 4.7 -10.5551 HNMR -10.5552 95 -10.556 ▁7.72 -10.556 ▁ethylacetate -10.5563 ▁mesh -10.5565 ▁86%) -10.5575 ▁Lithium -10.5579 nicotinamide -10.5581 ▁1.12 -10.5597 ▁6.4 -10.5605 ▁made -10.5611 ▁7.69 -10.5612 ▁0.99 -10.5614 39 -10.562 ▁140 -10.562 ▁except -10.5623 )-1,2,4- -10.5624 phase -10.5627 succinimide -10.5628 ▁synthesis -10.5635 ▁1.65 -10.5637 -4(3 -10.5641 ation -10.5641 0.9 -10.5646 decan -10.5646 ▁(98 -10.5648 hydroxylamine -10.5658 [1,2,4] -10.566 ˜ -10.5669 3.8 -10.567 ▁7.08 -10.5671 ▁7.14 -10.5685 }-3- -10.5686 ▁(6.4 -10.5706 ▁presence -10.571 ▁125 -10.5714 sulfonamido -10.5722 chloroethyl -10.5729 ▁10.2 -10.5733 ▁piperazine -10.5737 ▁1.13 -10.5737 ▁viscous -10.5741 ▁7.85 -10.5743 ▁o -10.5746 wise -10.5757 ▁Solvent -10.5762 ▁(79 -10.5763 ▁10.8 -10.5766 ▁5.00 -10.577 ▁3.90 -10.5773 ▁(83 -10.5774 cephem -10.5775 ▁(50.0 -10.5779 ]+= -10.5783 ▁130 -10.579 ▁1.31 -10.5801 et -10.5814 ▁12.5 -10.5818 Ethyl -10.5824 ▁but -10.5829 ▁approximately -10.5835 ▁7.11 -10.5836 ▁66 -10.5869 -1-(3- -10.5872 ▁4.1 -10.5872 ▁(81 -10.5882 ▁1.03 -10.5884 butanoate -10.5885 ▁(92 -10.5896 ▁70% -10.5902 ▁1.07 -10.5915 ▁5.1 -10.5922 36 -10.5932 ▁(6.6 -10.5933 (2,5- -10.5943 0.3 -10.5943 ▁(0.02 -10.5944 ▁(2×100 -10.5946 ▁1.01 -10.5947 ▁7.88 -10.5956 ▁7.71 -10.5957 ▁7.66 -10.5959 ▁89%) -10.5961 dihydropyridine -10.5968 ▁(87 -10.5972 ▁(0.06 -10.598 ▁(0.47 -10.5994 ▁(5.7 -10.6011 silane -10.6012 ▁78%) -10.602 1.9 -10.6023 ▁7.90 -10.6027 ▁(6.1 -10.6027 de -10.6028 ▁2.35 -10.6037 ▁3.80 -10.6043 ▁2.20 -10.6043 ▁7.82 -10.6049 ▁3-(5- -10.6056 ]+, -10.607 ▁1.55 -10.607 benzylamino -10.6073 ▁1.49 -10.6074 4.8 -10.6084 ▁(0.03 -10.6088 ▁7.04 -10.6095 ▁0.79 -10.6104 ▁(3.7 -10.6105 ▁7.67 -10.6106 ▁1.21 -10.6107 ▁Column -10.6108 ▁59 -10.6109 ▁stand -10.611 ▁(6.2 -10.6111 ▁(9.0 -10.6113 ,12 -10.6129 ▁psi -10.6135 -6-(4- -10.6136 ▁7.73 -10.6136 fluorophenoxy -10.6154 ▁96 -10.6169 ▁(280 -10.6171 =2.1 -10.6174 ▁diethylether -10.6187 ▁(0.08 -10.6189 )-1-(3- -10.6192 =5.6 -10.6192 ▁CuI -10.6199 propionamide -10.62 dioxol -10.6201 at -10.6207 ▁7.74 -10.6217 acetophenone -10.6219 ▁1.19 -10.6221 38 -10.6223 bottom -10.6239 ▁borane -10.6245 methylpiperazine -10.6256 ▁(3.9 -10.6258 ▁POCl -10.6265 dimethoxyethane -10.6269 ▁98%). -10.6271 00 -10.6274 ▁(900 -10.6275 triazine -10.6275 bottomed -10.6295 methoxyethyl -10.6298 ▁3.88 -10.6306 0.00 -10.6306 propionyl -10.6307 )-9 -10.6308 ▁flow -10.6309 ▁160 -10.6309 ▁thin -10.6318 ▁dioxide -10.6318 ▁formaldehyde -10.6324 ▁8.00 -10.6329 EA -10.633 ▁2.40 -10.6334 ▁(0.04 -10.6335 enoic -10.6337 ▁160° -10.6339 ▁3.87 -10.634 ▁weight -10.6342 0.0 -10.635 ▁gradually -10.6354 ▁dimethylamine -10.636 ▁1.60 -10.6368 6.4 -10.6384 ▁(8.5 -10.6389 5% -10.639 ▁3.78 -10.6393 ▁(260 -10.6402 =1 -10.6415 ▁7.83 -10.6417 iodophenyl -10.6422 pentane -10.6426 -7-( -10.6441 ▁(4.3 -10.6456 ▁(9.5 -10.6457 9° -10.6464 ▁1.09 -10.6471 ▁wise -10.6487 BuLi -10.65 ▁7.79 -10.6503 ▁not -10.6508 ▁pre -10.6522 ▁first -10.6531 trityl -10.6532 ance -10.6548 ▁bromoacetate -10.6555 ▁having -10.6557 ▁4.7 -10.656 4-(4,4,5,5- -10.6564 2% -10.6567 46 -10.6568 ▁78 -10.6577 ▁92%). -10.6577 ▁6.3 -10.6578 ▁3.89 -10.6582 =2.5 -10.6583 ▁6.98 -10.6587 ▁(93 -10.6589 benzamido -10.66 ▁3.95 -10.6601 ▁6.95 -10.6605 ▁RP -10.661 ▁pyrrolidine -10.661 ▁88%). -10.6612 ▁4,5- -10.6617 ▁3.82 -10.6625 ▁2.55 -10.6631 5.8 -10.6634 ▁81%) -10.6636 alanine -10.6637 +1) -10.6649 ro -10.665 ▁(5.9 -10.6651 4% -10.6671 ▁beige -10.6672 benzylamine -10.6673 diazepin -10.6675 7.6 -10.6679 ▁1,8- -10.668 methoxymethoxy -10.6682 ▁2.30 -10.6683 ▁iodine -10.6686 ▁3,3- -10.6693 ▁72%) -10.6695 proline -10.6696 ▁61 -10.6696 1° -10.6696 ▁(97 -10.6697 (5- -10.6699 6% -10.6704 ▁2.15 -10.6708 ▁quantitative -10.6711 -4,5,6,7- -10.6728 ▁resin -10.673 ▁1.85 -10.6736 ▁so -10.6738 2.6 -10.6743 G -10.6746 ▁68 -10.6746 ▁7.76 -10.6747 ▁4.9 -10.6752 ▁glass -10.6758 ▁(0.56 -10.6762 6.7 -10.6763 ion -10.6768 ▁(0.49 -10.677 ▁(0.54 -10.6774 =1.6 -10.6778 ▁70%). -10.6785 ▁99% -10.6787 ▁stream -10.6792 ▁7.09 -10.6796 ▁3.92 -10.6796 9.4 -10.6803 ▁(2×) -10.6807 ▁1.56 -10.6821 ▁7.84 -10.6822 ▁7.95 -10.6828 ▁HOBT -10.6829 ▁3.86 -10.6833 5.5 -10.6843 ▁4,6- -10.6849 ▁7.86 -10.6852 ▁96%). -10.6858 ur -10.6861 ▁7.77 -10.6865 ▁(0.52 -10.6865 ▁crystal -10.687 ▁7.92 -10.6872 FN -10.6874 ×3). -10.6876 dba -10.6894 ­ -10.6897 trimethylsilane -10.6899 ▁trifluoride -10.6903 ▁3.70 -10.6904 ▁8.05 -10.6908 18, -10.691 ▁7.81 -10.6912 nitropyridine -10.6915 [2.2.2] -10.6915 from -10.6919 34 -10.6927 ▁62 -10.696 ▁11.0 -10.6961 is -10.6964 ▁3.81 -10.6966 ▁93%). -10.6971 ▁2.05 -10.6976 7.7 -10.6979 ▁(115 -10.6979 6.8 -10.6988 =2.3 -10.699 8.6 -10.6992 -18 -10.6993 8.5 -10.6999 )-3,5- -10.7003 =5.2 -10.7005 butanoic -10.7011 )-3-(3- -10.7011 azepin -10.7013 ▁1.64 -10.7015 ▁(105 -10.7015 ▁7.07 -10.7016 75 -10.7019 ▁7.87 -10.7028 ▁2.75 -10.703 9.9 -10.704 ▁(360 -10.705 ▁7.03 -10.7053 ▁3.84 -10.7056 ▁(94 -10.708 ▁60%). -10.7083 ▁1.95 -10.7084 gradient -10.709 ▁(91 -10.709 Preparation -10.7096 ▁82%). -10.7099 ▁mobile -10.7104 ▁Calc -10.7107 ▁1.54 -10.7107 ▁bromo -10.7109 ▁6.97 -10.7112 ▁67 -10.7119 (5 -10.7132 0.8 -10.7133 (1,1- -10.7134 dibenzo -10.7135 ▁(4.9 -10.7142 ▁6.7 -10.7144 ▁35° -10.7145 ▁kept -10.7146 ▁expected -10.7149 bromopyridin -10.7151 8.9 -10.7155 pyrimidinyl -10.7164 ▁2.45 -10.7172 ▁de -10.7174 chloroperbenzoic -10.7176 ▁7.89 -10.7177 ▁(0.53 -10.7184 (2,2,2- -10.7184 ▁passed -10.7188 ▁76 -10.7193 {[( -10.7197 ▁no -10.7197 ▁target -10.7198 ▁(0.85 -10.7199 ▁ketone -10.7202 fluoren -10.7203 ▁7.06 -10.7203 ▁2.22 -10.7207 ▁85% -10.7212 ▁2-(1- -10.7213 ▁5.7 -10.7217 Yield -10.7217 ve -10.7218 ▁5.3 -10.7221 ▁2.32 -10.7226 (1,3- -10.7226 nicotinate -10.7231 47 -10.7241 octan -10.7242 ▁3.91 -10.7248 ▁71%) -10.7255 ▁1.52 -10.7256 [2.2.1] -10.726 ▁2.95 -10.7263 ▁11.7 -10.7267 ▁2.27 -10.7268 ▁(1.15 -10.7271 ▁87%). -10.7273 ▁1.11 -10.7275 ▁2.65 -10.7276 ▁Diethyl -10.7285 ▁5.8 -10.7286 ▁2.10 -10.7287 -1,3,4- -10.729 ▁7.02 -10.7291 2: -10.7293 yellow -10.7299 ▁monitored -10.7303 ▁2.36 -10.7305 ▁−70° -10.7309 ▁2.60 -10.7315 quinoxalin -10.7318 ▁1.51 -10.7319 ▁(0.58 -10.7341 silanyloxy -10.7345 ▁(12.5 -10.735 ▁4-(6- -10.7352 ▁(320 -10.7356 ▁(0.51 -10.7358 diisopropylamine -10.7371 cyclobutane -10.7378 =1.2 -10.7382 ▁2.42 -10.7382 ▁dichloroethane -10.7385 ▁(89 -10.7391 ▁3.65 -10.7392 -4′- -10.7401 =6.3 -10.7414 )-2-(3- -10.7415 ▁6-(4- -10.742 ▁cc -10.742 ▁3.74 -10.7421 ▁isobutyl -10.7427 ▁(10.5 -10.743 ▁minute -10.7432 ▁2.44 -10.7435 ▁brs -10.7436 dimethoxybenzyl -10.7443 85 -10.7443 ▁75%). -10.7444 ▁63 -10.745 ▁total -10.7452 2/ -10.7452 ▁(4.1 -10.7453 ▁2-(6- -10.7454 ]-1,3- -10.7457 ]+; -10.7457 methylpropan -10.7458 ▁(0.62 -10.7467 ▁3.79 -10.7468 ▁220 -10.747 ▁68%) -10.7477 ▁Palladium -10.748 ▁(0.57 -10.7494 ▁(1.20 -10.7494 ▁3.83 -10.7503 up -10.7508 ▁1.62 -10.751 ▁(0.100 -10.7523 0.6 -10.7531 ▁(6.7 -10.7536 ▁2-(( -10.7539 ▁such -10.7544 CI -10.7545 ▁6.90 -10.7552 le -10.7554 phenylmethyl -10.7554 5.9 -10.7557 ▁2.28 -10.756 7.4 -10.7562 ▁2.38 -10.7563 ▁(0.07 -10.7581 ▁7.01 -10.7589 -7,8- -10.7591 ▁2.24 -10.7591 3.6 -10.7592 8% -10.7593 ▁1.58 -10.7593 ated -10.7593 ▁(0.63 -10.7594 -1,3,5- -10.7597 ▁(0.80 -10.7599 ▁2.34 -10.76 =6.5 -10.7621 ▁83%). -10.7633 ▁7.91 -10.7634 trichloro -10.7635 isoindole -10.7637 1% -10.764 Ph -10.7648 ▁1.53 -10.765 diethylamino -10.7653 ▁97%). -10.7654 (4,4,5,5- -10.7663 -[1,3] -10.7664 ▁(0.70 -10.7665 ch -10.7665 ▁substituting -10.7665 ▁(3×100 -10.7676 ▁1.76 -10.7677 ▁10.7 -10.7691 =2.2 -10.7693 × -10.77 ▁conversion -10.7703 ▁7.93 -10.7706 -(( -10.7708 ▁(0.95 -10.771 8.8 -10.7712 ▁4-(1- -10.7723 diethoxy -10.7732 ▁four -10.7734 )-6,7- -10.7738 Si -10.7743 Bis -10.7743 ▁2.43 -10.7744 ▁77 -10.7747 ▁1% -10.7749 ▁6.96 -10.7749 ▁7.96 -10.7755 ▁3.72 -10.7756 -[1,3,2] -10.7758 ▁3.76 -10.776 carbon -10.7765 ▁8.06 -10.7769 48 -10.7771 methylbenzene -10.7773 ▁2.29 -10.7776 ▁requires -10.7785 ▁3.93 -10.7788 ▁1.57 -10.7791 ▁aniline -10.7793 ▁(99 -10.7794 ▁(0.01 -10.7797 ▁1.68 -10.7804 cooled -10.7807 tetrafluoro -10.7813 ▁add -10.7821 ▁84 -10.7841 ▁7.98 -10.7842 tosyl -10.7845 isoindoline -10.7846 7% -10.7847 ▁84%). -10.7855 ▁91%). -10.7859 ▁(6.8 -10.7873 ▁Acetic -10.7876 IV -10.7882 ▁7.94 -10.7886 ▁(30.0 -10.7889 ▁3.96 -10.7894 )-4-(2- -10.7895 ▁2.37 -10.7901 ▁6.99 -10.7906 ▁2.64 -10.7909 ▁6.2 -10.7916 ▁mins -10.7922 ▁2.17 -10.7923 ▁3.94 -10.7924 bath -10.7933 =5.1 -10.7934 ▁1.72 -10.7934 49 -10.7937 ▁(135 -10.794 acetaldehyde -10.7941 indoline -10.7944 ▁1.61 -10.795 methylamine -10.795 nitrobenzyl -10.7951 ▁thereby -10.7953 ▁performed -10.7953 ▁1.82 -10.7973 ▁10.1 -10.7987 diboron -10.799 ▁al -10.7997 ▁irradiation -10.7998 ▁3.60 -10.8001 -5-(3- -10.8002 ▁2.18 -10.8007 ▁2% -10.8009 ▁medium -10.8016 ▁4.05 -10.8018 ▁sub -10.802 piperidyl -10.8021 ▁1.59 -10.8028 ▁79 -10.803 nicotinonitrile -10.8041 Benzyloxy -10.8042 ▁3.71 -10.8053 ▁(0.68 -10.8057 }-4- -10.806 ▁3.05 -10.8064 ▁2.26 -10.8065 ▁88 -10.8065 ▁can -10.8079 -11- -10.8082 3.7 -10.8085 ▁plug -10.8091 ▁2.56 -10.8093 ▁69 -10.8099 oxopropyl -10.8101 -2-(1- -10.8102 ▁7.97 -10.8105 ul -10.8109 ▁Silica -10.8119 pyrrolidinyl -10.8122 ▁aluminium -10.8126 (2,6- -10.8143 ▁2.02 -10.8152 ▁all -10.8153 Me -10.816 ▁6.92 -10.8163 ▁(5% -10.8165 =9.2 -10.8185 ▁2.46 -10.8187 ▁1.63 -10.8187 k -10.8194 ▁2.31 -10.8196 ▁loaded -10.8196 )-5,6- -10.8202 )-3-(( -10.8207 ▁3.73 -10.8209 ▁3.50 -10.8209 ▁1.74 -10.8214 ▁1.67 -10.8215 ▁86 -10.8216 =5.5 -10.8217 ▁night -10.822 ▁2.41 -10.823 98 -10.8233 ▁3.25 -10.8235 ▁69%) -10.8237 { -10.824 dihydropyridin -10.824 ▁1.78 -10.8255 ▁3.77 -10.8256 ▁1.86 -10.8256 ▁2.33 -10.8256 ▁600 -10.8257 ▁3.20 -10.8259 phosphonate -10.8266 ▁8.15 -10.8267 (4,4- -10.8267 ▁(0.64 -10.8268 ▁NBS -10.8274 )-2,6- -10.8275 ▁lyophilized -10.8281 ▁2.19 -10.8285 ▁1.80 -10.8285 ▁11.8 -10.8288 ▁2.63 -10.8289 ▁et -10.8289 ▁8.12 -10.8291 9.6 -10.8293 ▁(0.66 -10.8294 ▁Aldrich -10.8295 ▁final -10.8299 ▁produce -10.8305 ▁2.16 -10.8307 ▁2.23 -10.8314 ▁2.85 -10.832 ▁(0.67 -10.832 pinacolato -10.8329 ▁Combine -10.8332 el -10.8332 ▁5-(3- -10.8335 ▁hydrobromide -10.8339 benz -10.8344 ▁([ -10.8347 ▁1.66 -10.8351 ISP -10.8351 ▁77%). -10.8356 -3-(1- -10.836 ▁1.84 -10.8361 ▁there -10.8369 ▁8.04 -10.8371 ▁ratio -10.8375 ▁11.6 -10.8376 -6-(2- -10.8376 ▁0% -10.8377 ▁(25.0 -10.8388 ▁refluxing -10.8391 ▁mono -10.8396 ▁6.85 -10.8397 [5.4.0] -10.8398 ▁1.83 -10.84 ▁crystallized -10.8401 oxazine -10.8401 ▁6.94 -10.8402 ▁7.99 -10.8405 ▁20.0 -10.8406 ▁3.68 -10.8422 ▁8.01 -10.843 =8.9 -10.8433 ▁11.5 -10.8435 ▁DCE -10.8443 -11 -10.8445 ▁sample -10.845 ▁2.14 -10.8455 9% -10.8455 :1) -10.8457 ▁2.57 -10.8462 ▁3.15 -10.8469 ▁81 -10.8471 ▁(7.6 -10.8472 ▁2.70 -10.8477 6,7,8,9- -10.8478 -20 -10.8478 ▁Chromatography -10.8487 ▁DBU -10.849 ▁74 -10.8492 ▁2.12 -10.8499 ▁(0.76 -10.8502 ▁ISCO -10.8503 oxadiazole -10.8506 ▁3.98 -10.8515 ▁(9.6 -10.8516 fluorobenzene -10.8516 ▁3.40 -10.8518 ▁8.02 -10.852 ▁2.58 -10.8523 aminopyridine -10.8525 ▁(12.0 -10.853 ▁6.1 -10.853 ▁2.80 -10.8532 ▁3-(1- -10.8534 ▁(0.72 -10.8535 ▁2.90 -10.8535 methylpyrrolidin -10.8539 ▁1.90 -10.8542 5.6 -10.8543 8.7 -10.8544 ▁8.10 -10.8553 ▁2.04 -10.8555 ▁2.78 -10.8557 azepine -10.8557 ▁73 -10.8559 Di -10.8561 ▁3.45 -10.8567 ▁62%) -10.8574 ▁1.70 -10.8576 ▁been -10.858 ▁inert -10.8592 Butoxycarbonyl -10.8592 ▁8.08 -10.8592 ▁2.54 -10.8599 ▁2.13 -10.8615 oxetan -10.8615 )-5-(4- -10.8625 ▁15° -10.8625 ▁catalytic -10.8632 ▁76%). -10.8635 ▁2.21 -10.8639 ▁2.39 -10.864 propanoyl -10.8641 ▁9.5 -10.8641 ▁8.20 -10.8647 ▁1.98 -10.8649 ▁recovered -10.8652 malonate -10.8653 ▁3.67 -10.8655 ▁15.0 -10.8655 ▁6.93 -10.8661 )-1,4- -10.8663 ▁3.97 -10.8669 ▁procedures -10.8672 toluenesulfonyl -10.8672 Trifluoroacetic -10.8673 ™ -10.8674 ▁CHLOROFORM -10.8678 ▁1.73 -10.8679 ▁0-100% -10.868 ▁Prep -10.8681 ▁180 -10.8683 ▁11.2 -10.8686 -[1,2,3] -10.869 ▁3.55 -10.8698 ▁2.48 -10.8712 9.5 -10.8713 ▁12.3 -10.8714 )+; -10.8716 ▁8.03 -10.8718 0.4 -10.8722 ▁1.96 -10.8725 methylpropane -10.8727 ▁2.88 -10.8728 [1,3] -10.8732 -2′- -10.8737 title -10.8739 ▁63%) -10.8744 ▁2.06 -10.8748 3% -10.876 ▁(0.050 -10.8763 ▁(1.10 -10.8763 ▁Subsequently -10.8765 ▁molecular -10.8767 allyloxy -10.8771 cyclohexanol -10.8774 ▁2.52 -10.8776 (2,2- -10.878 ca -10.8784 ▁(2× -10.8787 ▁f -10.8789 ▁(101 -10.879 ▁second -10.8791 ▁(1.08 -10.8792 ▁TBAF -10.8797 ▁(0.09 -10.88 ▁formamide -10.8801 )-3,3- -10.8805 Benzyl -10.8807 -2.5 -10.8814 ▁2.68 -10.8815 ▁1.92 -10.8818 LC -10.882 ▁order -10.8834 )-1-(( -10.8842 ▁(330 -10.8843 ▁LiAlH -10.8846 ▁back -10.8849 =5.0 -10.8851 ▁13.2 -10.8852 ▁Evaporation -10.8853 il -10.8855 ▁react -10.8858 ▁−40° -10.888 ▁4.15 -10.8891 ter -10.8893 ▁6.88 -10.8893 =5.4 -10.89 propylamine -10.8902 ▁2.86 -10.8903 ▁79%). -10.8903 ▁3.30 -10.891 ▁(2×20 -10.8912 dried -10.8913 benzylidene -10.8922 ▁place -10.8938 ▁(0.61 -10.894 ▁10.9 -10.8944 ▁[1,1′- -10.8951 carbazole -10.8953 ▁racemic -10.8953 ▁2.67 -10.8953 200 -10.8953 ▁4.25 -10.8959 intermediate -10.896 ▁6.89 -10.8962 ethenyl -10.8967 glycine -10.8972 ▁(1.35 -10.8973 -4-(1- -10.8976 ,10 -10.8981 ▁2.76 -10.8984 hydrazino -10.8986 dihydrospiro -10.8987 (3,4,5- -10.8989 =6.7 -10.8995 ▁65%). -10.9005 ▁170 -10.9005 -2(3 -10.9011 ▁completed -10.9013 ▁180° -10.9014 ▁(1:1 -10.9015 benzoylamino -10.9015 ▁8.25 -10.9021 -[1,1′- -10.9023 ▁2.87 -10.9024 ▁(5.1 -10.9025 ▁3.62 -10.9025 +]. -10.9025 ▁11.4 -10.9035 65 -10.9038 ▁(0.73 -10.9042 ▁5.9 -10.9053 ethan -10.9058 ▁Benzyl -10.9059 (6 -10.9065 ▁OCH -10.9067 ▁apparatus -10.9067 BuOH -10.9067 cyclo -10.9072 ▁8.16 -10.9073 ▁3.66 -10.9074 ylboronic -10.9075 -[2- -10.9076 benzazepine -10.9077 ▁73%). -10.9089 ▁71 -10.909 ▁2.61 -10.9096 ▁required -10.9107 sulfinamide -10.9108 ▁3.69 -10.912 ▁4.50 -10.9121 ▁diphenyl -10.9123 ▁(1.06 -10.9133 ent -10.9133 ▁74%). -10.9134 ▁91 -10.9143 dioxa -10.9145 ▁(7.8 -10.9146 ▁2.92 -10.9146 ▁2.62 -10.9157 ylcarbamoyl -10.9161 ▁12.4 -10.9164 ichloropalladium -10.9165 41 -10.9171 ▁(175 -10.9183 ▁6.91 -10.9186 benzoimidazol -10.9189 ▁98 -10.9195 ▁3.58 -10.9201 ▁(3×20 -10.9201 ▁activated -10.9202 ▁2.08 -10.9203 ▁4.35 -10.9209 ▁2.94 -10.9212 ▁(0.84 -10.9219 ▁8.14 -10.922 ▁oxime -10.9221 ▁3.99 -10.9222 ▁xylene -10.9224 ▁8.13 -10.9225 ▁separation -10.9226 ▁6.84 -10.9227 ▁(7.2 -10.9229 ▁8.11 -10.923 re -10.9233 ▁4′- -10.9235 eluting -10.9241 anilino -10.9245 (2-(4- -10.925 ▁wash -10.9255 ▁Thereafter -10.9258 ▁8.09 -10.9262 ▁1.88 -10.9262 ▁When -10.9266 9.8 -10.9275 ▁butyl -10.9279 ▁1.87 -10.9282 benzothiazole -10.9282 +1]+. -10.9283 ▁2.53 -10.9293 ▁12.2 -10.9299 ▁12.8 -10.9301 ▁83 -10.9307 ▁6.80 -10.9316 pH -10.9317 ▁8.18 -10.9324 ▁UV -10.9327 ▁98% -10.9327 ▁4.10 -10.9329 ▁9.6 -10.9333 ▁2.47 -10.9334 0.5 -10.9339 ▁8.07 -10.9342 pentan -10.9342 ▁3.64 -10.9343 ▁4.12 -10.9343 methylbenzoic -10.9343 ▁8.22 -10.9347 =1.9 -10.9348 ▁dichloro -10.9352 ▁2.89 -10.9359 +1)+. -10.9366 ▁94 -10.937 ▁8.17 -10.9372 ▁e -10.9372 ▁Additional -10.9374 furyl -10.938 97 -10.9383 ▁9.2 -10.9386 ▁4.20 -10.9387 ▁Retention -10.9387 )-2,2,2- -10.9391 ▁By -10.9396 ▁4.17 -10.9398 ▁2.96 -10.9399 ▁(9.4 -10.9404 =5.8 -10.9417 ▁5,6- -10.9419 ▁(±)- -10.9421 ▁1.97 -10.9428 ▁6.82 -10.9428 ▁1.69 -10.9439 ▁2.84 -10.9441 79 -10.9442 sulfonyloxy -10.9451 Cyano -10.946 ▁3.56 -10.9461 ▁35% -10.9465 ▁6.87 -10.9465 ▁6.86 -10.9468 =5.7 -10.9468 ▁treatment -10.9468 ▁(0.77 -10.947 ▁3.59 -10.9477 ((2-( -10.9484 ▁12.6 -10.9486 ▁dicyclohexyl -10.9487 ,9- -10.9495 CAS -10.95 ▁(1.04 -10.95 ▁2.77 -10.9503 ▁8.9 -10.9507 ▁3.63 -10.9513 sodium -10.952 ▁3.03 -10.9522 ▁(1.12 -10.9527 ▁Raney -10.9538 -(2,4- -10.9542 )-2,4- -10.9543 ▁1.77 -10.9546 ▁3.57 -10.955 ▁2.82 -10.9552 triisopropyl -10.9552 ▁phenol -10.9553 )-[1,2,4] -10.9554 ▁2.98 -10.9563 heptan -10.9566 (6- -10.957 ▁3.35 -10.9579 benzenesulfonate -10.9581 {[2-( -10.9584 ▁(0.59 -10.9586 difluorobenzyl -10.9587 ▁co -10.9592 ▁0.001 -10.9594 ▁2.59 -10.96 nitropyridin -10.9601 ▁2.11 -10.9612 ▁(0.78 -10.9613 ▁66%). -10.9617 ▁6.83 -10.9619 ▁per -10.962 ▁(9.2 -10.9624 ▁4.08 -10.9631 ▁(0.025 -10.9633 ▁3.48 -10.9638 ▁Ph -10.9639 ▁(0.71 -10.9664 ▁(1.03 -10.9668 ▁2.09 -10.967 ▁Toluene -10.9683 ▁2.73 -10.9684 ▁4.40 -10.9684 ▁× -10.9687 ▁2.81 -10.9689 ▁(9.7 -10.9704 ▁1.89 -10.9709 ▁(6.9 -10.9712 ▁2.91 -10.9714 · -10.9717 ▁(8.4 -10.972 broad -10.9722 =2.7 -10.973 ▁6.78 -10.9732 ▁1.71 -10.9739 ▁1.94 -10.974 =6.2 -10.975 ]-7- -10.9761 ▁(8.3 -10.9765 propenyl -10.977 ▁(112 -10.9772 ▁peak -10.9773 ▁6.75 -10.9776 ▁(1.16 -10.978 5.7 -10.9781 cyanomethyl -10.9781 ▁1-(6- -10.9791 ▁(0.74 -10.9794 ▁(550 -10.9799 bromoethyl -10.98 ▁hydrogenated -10.9801 ▁3.06 -10.9802 ▁2.03 -10.9807 ▁(7.4 -10.9809 ▁(2.50 -10.9813 ]+: -10.9818 ▁13.5 -10.9821 ° -10.9822 ▁converted -10.9826 ▁4.30 -10.9826 necked -10.9829 ▁99 -10.9832 ▁3.01 -10.9833 ▁2.72 -10.9833 methylcarbamoyl -10.9834 ▁(1.02 -10.9836 -3,6- -10.9836 ▁appropriate -10.9839 [3.1.0] -10.9843 ▁(±) -10.9846 ▁3.16 -10.9847 ▁57%) -10.9848 Hex -10.985 ▁W -10.9856 ▁4.02 -10.9858 ▁8.19 -10.9863 ▁Tri -10.9863 ▁53%) -10.9863 ▁1:1) -10.9864 ▁Tert -10.9866 (8- -10.9868 Difluoro -10.987 ▁2.83 -10.9871 ₄ -10.9873 -(3,4- -10.9873 ▁dihydrate -10.9878 ▁(0.88 -10.9879 ▁(7.7 -10.9884 }-5- -10.9886 ▁produced -10.9887 ▁2.49 -10.9889 )-2-[( -10.9896 ▁triphenyl -10.9897 enoate -10.9898 ▁67%). -10.9899 3( -10.9904 ×2). -10.991 ▁day -10.9916 ▁EXAMPLE -10.9919 etrafluoroborate -10.9921 -1,8- -10.9926 ▁2.93 -10.9936 Hexane -10.9937 -[1,4] -10.994 ▁yellowish -10.9952 pyrrolidone -10.9954 ▁2.97 -10.9955 ▁2.74 -10.996 ▁87 -10.9962 KBr -10.9964 −1 -10.9967 ▁(8.8 -10.9968 ▁Z -10.9971 ▁3.18 -10.9972 ▁(1.07 -10.9972 ▁4.32 -10.9974 ▁37% -10.9974 ▁240 -10.9979 ▁8.28 -10.9982 ▁commercially -10.9982 ylthio -10.9985 ▁(2×10 -10.9987 ▁(0.69 -10.999 ▁8.21 -11.0002 ▁0.025 -11.0013 ▁3.08 -11.003 ▁half -11.0031 ▁89 -11.0037 ▁ethoxide -11.0041 ▁redissolved -11.0041 ▁3.12 -11.0041 ▁105 -11.0048 ▁3.10 -11.0049 ▁(8.2 -11.005 ▁2.66 -11.0052 ▁-10° -11.0052 Et -11.0056 ra -11.0057 ▁4.04 -11.0061 -(1 -11.0062 ▁3.38 -11.0063 ▁HBTU -11.0064 ▁8.30 -11.007 elting -11.007 butyryl -11.0076 dioxaspiro -11.0077 )+= -11.0077 ▁64%). -11.008 nitrobenzoic -11.0092 ▁1.99 -11.01 ▁(1.14 -11.0106 ▁(1.13 -11.0107 ▁formula -11.0109 ▁(10.2 -11.0112 cyclopent -11.0112 containing -11.0113 55 -11.0113 ▁2.69 -11.0114 pyrrolidinone -11.0119 ▁4.16 -11.012 octyl -11.0129 ▁82 -11.0129 ▁(0.82 -11.0134 butylphosphine -11.0135 ▁2.99 -11.0137 trifluoroethoxy -11.0143 ]− -11.0144 -4,4- -11.0146 Step -11.0147 diazepine -11.0149 ▁2.07 -11.0152 ▁buffer -11.0153 ▁12.1 -11.0158 ▁(0.90 -11.0173 phthalazin -11.0176 ▁51%) -11.0186 ▁97 -11.0188 ▁4.14 -11.019 ▁pos -11.0192 gel -11.0202 phenylthio -11.0204 ▁8.24 -11.021 ▁(1.01 -11.021 ▁& -11.0212 oic -11.0212 -1,1′- -11.0216 ▁8.26 -11.0224 ▁3.31 -11.0232 ▁Eq -11.024 CHCl -11.0241 ▁Fractions -11.0245 ▁2.01 -11.0246 ▁BBr -11.025 -(4-( -11.0254 ▁4.01 -11.0254 ▁3.36 -11.0255 ▁8.23 -11.0257 phenylalanine -11.026 ▁(20% -11.026 ▁(0.92 -11.0265 [1- -11.0265 (9 -11.0266 ▁11.1 -11.0266 ▁(1.75 -11.0276 ▁gives -11.0277 ▁resulted -11.0282 ice -11.0283 nitroaniline -11.0289 81 -11.0291 chromen -11.0293 ▁1.93 -11.0298 ▁˜ -11.03 trifluoromethane -11.0304 ▁thick -11.0308 thiol -11.0326 ▁4.11 -11.0332 ▁4.13 -11.0333 ▁3.54 -11.0333 ▁(0.86 -11.0337 ▁3.07 -11.0347 ▁Dean -11.0353 ▁amino -11.0355 ▁(340 -11.0357 ▁75% -11.0358 ▁4.27 -11.0358 phenoxymethyl -11.036 ▁acetal -11.0362 ▁3.52 -11.0369 ▁(1.26 -11.0377 ▁1.79 -11.0388 ▁4.29 -11.0389 Stark -11.0394 ▁4.06 -11.0394 ▁(3×10 -11.0394 ▁(650 -11.0395 99 -11.0398 dimethylpyridin -11.0406 ▁3.22 -11.041 neck -11.0411 triaza -11.0413 +1 -11.0415 ▁Concentration -11.0416 ▁4.23 -11.0417 ₃ -11.0418 TFA -11.042 -[2-( -11.0432 ▁3.39 -11.0437 ▁2.79 -11.0446 ▁4.07 -11.045 ▁(1.45 -11.0459 ▁(0.87 -11.0467 ▁4.45 -11.0468 9.7 -11.0468 )-1,3,4- -11.047 ▁HOAc -11.0477 ▁3.24 -11.0477 ▁11.9 -11.0479 ▁4-(( -11.048 44 -11.0484 propylamino -11.0492 ▁92 -11.0495 ▁(290 -11.0497 ▁Scheme -11.0501 ▁350 -11.0505 ▁6.70 -11.0505 ▁115 -11.0511 TLC -11.0513 se -11.0519 ▁Mobile -11.0522 ▁4.18 -11.0524 -4(5 -11.053 trifluoroacetyl -11.053 ▁-20° -11.0531 [5- -11.0537 ▁6-(2- -11.0541 ▁2,4,6- -11.0542 ▁6.81 -11.0543 ▁4.03 -11.0543 ▁(0.83 -11.0545 ▁(116 -11.0545 ▁11.3 -11.0555 ▁4.26 -11.0556 ▁shaken -11.0556 ▁(108 -11.0557 Nitro -11.056 ▁3.02 -11.056 ▁8.32 -11.0563 ▁internal -11.0566 ane -11.0566 )-6-(4- -11.0568 ▁3.33 -11.057 ▁3.28 -11.0571 ▁(0.96 -11.0573 )-5-(2- -11.0575 ▁(1.65 -11.0576 ▁3.47 -11.0582 ▁2.71 -11.0582 Iodo -11.0584 ▁4.34 -11.0598 67 -11.0603 ▁12.7 -11.0604 benzotriazol -11.0608 ▁(11.5 -11.061 }-1- -11.0611 ▁accord -11.0619 ▁3.46 -11.0619 =5.9 -11.062 thiadiazole -11.0622 nitrophenoxy -11.0641 ▁(1.38 -11.0652 ▁4.22 -11.0656 ▁3.42 -11.0657 ▁1.81 -11.0665 100 -11.0671 ▁triphosgene -11.0671 ▁3.14 -11.0672 ▁3.04 -11.0674 ▁cyclopropane -11.0675 -((1 -11.0675 nitrobenzoate -11.0678 ▁4.38 -11.0689 ▁(145 -11.0693 ▁3.23 -11.0695 ▁see -11.0697 ▁(4.00 -11.071 methylcarbamate -11.0712 th -11.0713 ▁8.35 -11.0717 ▁(126 -11.0719 ▁4.28 -11.0722 ▁V -11.0729 (3,4- -11.0732 ▁sulfite -11.0734 78 -11.0734 ▁(1.18 -11.074 methylbenzoate -11.0746 ▁4,4- -11.0749 ▁3.61 -11.0755 ▁Calculated -11.0759 ▁3.13 -11.077 ▁(106 -11.0775 ▁2.51 -11.0785 ▁nickel -11.0787 ▁(9.8 -11.079 ▁0.005 -11.0791 ▁0.015 -11.0793 ▁4.31 -11.0796 ▁(8.6 -11.0799 ▁−5° -11.0801 2.7 -11.0809 [(2- -11.0809 ▁(114 -11.0811 ▁3.44 -11.0817 -[3- -11.0822 ▁sulfide -11.0824 U -11.0833 ▁4.65 -11.0835 )-4-(( -11.084 ▁3.17 -11.085 ▁replace -11.0854 ▁(380 -11.0855 benzoxazol -11.0856 cold -11.0858 ▁13.6 -11.0859 ▁(0 -11.0862 ▁3.41 -11.0868 )-1,2- -11.087 ▁100%) -11.0875 ▁8.31 -11.088 -100% -11.0885 87 -11.0886 ▁4.36 -11.0887 ▁(1.30 -11.0888 benzopyran -11.089 ▁manganese -11.089 ▁3.26 -11.0891 ▁(0.98 -11.0893 ▁3.11 -11.0898 ▁(0.93 -11.0905 ▁199 -11.0906 =1.7 -11.0911 ▁mMol -11.0912 ▁145 -11.0914 ▁4.42 -11.0915 ▁HBr -11.0916 ▁93 -11.0917 ▁4.33 -11.092 ▁standing -11.0921 ▁3.51 -11.0927 ▁56%). -11.0927 ▁4.37 -11.0933 ▁8.29 -11.0933 ▁3.34 -11.0933 ▁benzoic -11.094 ▁12.9 -11.0946 ▁8.27 -11.0967 ▁SCX -11.0973 ▁tin -11.0982 ▁4.24 -11.0983 nitrophenol -11.0986 ▁3.27 -11.0986 chloropyridine -11.099 phenoxyphenyl -11.099 ▁value -11.0997 ▁flushed -11.0997 ▁13.0 -11.1009 ▁Me -11.101 indene -11.1014 ▁SOCl -11.1015 ▁8.33 -11.1019 ▁55%). -11.1022 ▁together -11.1033 ▁umol -11.1035 ▁4.55 -11.1038 ▁its -11.1044 ▁    -11.1045 (1,4- -11.1046 (4-(4- -11.1048 ▁6.65 -11.1056 ▁repeated -11.1056 ▁4.21 -11.1058 ▁(1.24 -11.1061 ▁adjust -11.1065 tetrazole -11.1066 ▁14.5 -11.1067 ▁4.09 -11.1075 ▁WO -11.1081 ▁1.91 -11.1084 formamide -11.1088 ▁Filtration -11.1095 ac -11.1097 ▁47%) -11.1099 ▁9:1 -11.11 ▁3.32 -11.1103 ▁nitric -11.1105 ▁TMS -11.1108 {[(1 -11.111 ▁(0.81 -11.1111 ▁(9.1 -11.1115 ▁8.40 -11.1117 ▁58%). -11.1119 ▁0-10% -11.112 ▁3.37 -11.1122 +1] -11.1132 ▁6.67 -11.1132 ethylenediamine -11.1133 ▁116 -11.114 (( -11.1156 57 -11.1157 +1]+ -11.1157 ▁8.38 -11.1158 ▁liter -11.1163 ▁2:1 -11.1164 ▁(11.0 -11.1173 ▁4.46 -11.1175 butyrate -11.1177 =5.3 -11.1177 ▁0.05% -11.1183 dihydroquinolin -11.1191 methoxyimino -11.1191 -[4- -11.1192 -4.2 -11.1195 ▁0.003 -11.1202 ▁4.19 -11.1202 ne -11.1208 ▁3.53 -11.1209 ▁6.79 -11.121 -5,7- -11.1215 ▁methane -11.1218 ▁254 -11.1223 benzodiazepine -11.1224 ▁Chemical -11.1226 ▁(1.17 -11.1229 nonane -11.1235 01 -11.1238 ▁(1.40 -11.1241 ▁(0.015 -11.1242 ▁(1.28 -11.1246 um -11.1248 ▁6.73 -11.1258 ▁3.19 -11.1263 ▁(9.3 -11.1268 ▁(10.6 -11.127 ▁16.5 -11.1273 bromopyridine -11.1273 ×2) -11.1274 ▁4.48 -11.1274 0.7 -11.1286 {2- -11.1287 ▁6.77 -11.129 -4(1 -11.129 )-2,5- -11.1301 ▁4.41 -11.1303 ▁4.60 -11.131 0° -11.131 (2,4,6- -11.1314 ▁making -11.1316 ▁4.52 -11.1319 ▁(8.7 -11.1321 ▁8.36 -11.1321 ▁Co -11.1326 =1.0 -11.1327 ▁(10.4 -11.133 (4′- -11.1334 ▁105° -11.1337 (3,5- -11.1339 ▁61%). -11.1349 ▁(7.1 -11.135 ▁Stir -11.1354 ▁(1.23 -11.1357 ▁6.60 -11.1359 ▁0.002 -11.136 ▁(10.3 -11.1371 ▁PPh -11.1374 ▁(1.27 -11.1387 ▁1,1'- -11.1388 ×3) -11.1389 ▁3.29 -11.14 -5-(4,4,5,5- -11.1409 ▁brought -11.1413 ri -11.1423 )-4-(3- -11.1427 ▁nitrate -11.1428 ▁(0.91 -11.1439 =0.8 -11.1446 -[4-( -11.1448 ▁Phase -11.1448 ▁keeping -11.1451 ▁8.34 -11.1458 ▁applied -11.1463 ▁vinyl -11.1467 ▁2× -11.1467 ▁(420 -11.1477 ▁benzaldehyde -11.1483 ▁corresponding -11.1483 pyrazino -11.1483 (1-( -11.1484 imidazolidine -11.1487 ▁earth -11.1488 ▁Ethanol -11.1489 max -11.1491 =6.1 -11.1491 ▁3.43 -11.1496 ▁crystallization -11.1497 ▁    -11.1498 methylpiperidine -11.1503 ▁IPA -11.1509 ▁4-[ -11.151 acrylamide -11.1513 ▁54%). -11.1517 indolin -11.1524 ▁4.62 -11.153 ▁3.21 -11.1531 ▁boiling -11.1531 methylpyrimidin -11.1539 ▁(0.94 -11.1539 ▁(113 -11.1542 ▁(1.21 -11.1543 sulphonyl -11.1545 -2-(5- -11.1548 ▁97% -11.1554 butanone -11.156 non -11.1566 isocyanato -11.1569 ▁3.49 -11.1576 DCI -11.1581 ▁52%). -11.1591 ▁6.72 -11.1593 ▁4.43 -11.1598 ▁(225 -11.1599 ▁4.39 -11.1617 ▁(10.8 -11.1621 ▁pyridinium -11.1638 ▁(13.5 -11.1648 =4.9 -11.1648 ▁8.45 -11.1649 ▁4.54 -11.165 methylaniline -11.1651 ▁wet -11.1653 Phenyl -11.1654 -3′- -11.1659 ▁APCI -11.166 dihydropyrido -11.1663 66 -11.1665 ▁vol -11.1673 =4.5 -11.1674 tris -11.1675 ▁(30% -11.1684 ▁(165 -11.1686 -[5- -11.169 isobenzofuran -11.1692 69 -11.1692 ▁Waters -11.1696 ▁45%). -11.1697 ▁6.71 -11.1698 ▁6.76 -11.1699 ▁3-(( -11.1701 ▁4.58 -11.1708 ▁vigorous -11.171 ▁6.66 -11.172 FAB -11.1721 ▁(1.09 -11.1722 -4-(5- -11.1725 morpholinyl -11.173 ▁triethylsilane -11.1731 05 -11.1744 ▁finally -11.1752 ▁(1.22 -11.1762 ▁syrup -11.1767 thioxo -11.1768 phthalimide -11.1782 Hydrochloric -11.1782 ▁(0.500 -11.179 ▁semi -11.1798 -1,2,3,6- -11.1798 ▁Further -11.1803 ▁(6- -11.1806 pyrano -11.1806 ▁heat -11.1821 ▁liters -11.1821 cyclohexanone -11.1825 68 -11.1827 ▁(138 -11.1844 =2.8 -11.1853 ▁(0.97 -11.1858 ▁(310 -11.1862 OCH -11.1862 chromene -11.1869 dioxan -11.1876 -(3,5- -11.1878 ▁49%) -11.1889 ▁(0° -11.189 pentamethyl -11.189 ▁(1.34 -11.1899 ▁(7.3 -11.19 ▁(0.200 -11.19 ▁4.44 -11.1904 ir -11.1906 ▁6.68 -11.1906 ▁(1.32 -11.1906 ▁methylmagnesium -11.1907 ▁4-[( -11.1908 ▁(0.89 -11.1919 ▁furnish -11.1921 hexanoic -11.1923 -2'- -11.1924 ▁benzoate -11.1933 ▁ESIMS -11.1934 ▁0.012 -11.1935 -2,4(1 -11.1938 propanenitrile -11.1941 96 -11.1942 ▁4:1 -11.1942 )-1,1- -11.1943 =9.1 -11.1947 ▁46%). -11.1952 ▁carboxylic -11.196 -2,2′- -11.1962 {2-[( -11.1963 ▁Diisopropyl -11.1965 ▁(118 -11.1966 ▁59%). -11.1967 ▁4.53 -11.1967 ▁Organic -11.1974 ▁48%). -11.1989 butyloxycarbonyl -11.199 (2,4- -11.1991 ▁For -11.1992 ▁8.39 -11.2002 ▁6.74 -11.2011 _ -11.2012 mer -11.2015 ▁9.3 -11.2021 benzoimidazole -11.2023 upon -11.2026 emoval -11.2032 ▁evolution -11.2033 ▁3.09 -11.2034 ▁acrylate -11.2035 -4'- -11.2038 {[4-( -11.2044 -1,3 -11.2045 =9.3 -11.2047 ▁(111 -11.2052 dihydropyrimidin -11.2053 ▁3-(6- -11.2055 fluorobenzoyl -11.2059 (6-( -11.2065 ▁(8.1 -11.2075 Bu -11.2077 ▁7-( -11.208 diyl -11.2083 ▁−30° -11.2086 ▁(1.36 -11.2089 )-2-(5- -11.2092 hydroxyimino -11.2094 tetrahydropyrido -11.2095 ▁leave -11.2096 ▁Hg -11.21 ▁data -11.2102 ▁(8.9 -11.2112 ▁Dichloromethane -11.2113 ▁8.48 -11.2114 ▁filtrated -11.2136 ]-2,3- -11.2137 ▁(107 -11.2138 ▁96% -11.2142 ▁diatomaceous -11.2145 58 -11.2146 ▁(10.1 -11.2148 ▁(11.2 -11.2157 ▁13.4 -11.2167 -7-(2- -11.2167 ▁separate -11.2174 ▁well -11.2177 ▁94% -11.2186 ▁(0.020 -11.219 see -11.2191 ▁malonate -11.2202 Dimethoxy -11.2207 ▁(3×). -11.2212 ▁13.8 -11.2216 ▁4.47 -11.2223 chloropyrimidin -11.2228 ▁40%) -11.2229 ▁14.4 -11.2229 ▁8.44 -11.2232 SR -11.2234 about -11.2238 =4.0 -11.2239 ▁6.62 -11.2241 thiazolidine -11.2243 methylbenzamide -11.2246 ═ -11.2247 ▁tetrahydro -11.225 ▁−15° -11.2263 59 -11.2268 ▁13.3 -11.2269 ▁13.1 -11.227 ▁(1.37 -11.2273 step -11.2273 ▁(104 -11.2274 ▁4.75 -11.2277 ▁(128 -11.2282 -6-(3- -11.2285 ▁hydrobromi -11.229 ▁8.50 -11.2292 hexan -11.2296 ▁Next -11.2301 naphtho -11.2313 ▁9.8 -11.2314 -[3-(4- -11.2316 methylbenzyl -11.2317 III -11.2318 DMF -11.2319 the -11.2337 (3-(4- -11.2343 butylamine -11.2347 88 -11.2348 ,10- -11.2352 ▁single -11.2354 51 -11.2356 ▁4.80 -11.2358 (5,6- -11.237 ▁8.55 -11.2373 [4,5] -11.2378 ▁(0.79 -11.2381 ▁210 -11.2396 =4.4 -11.2397 ▁3:1 -11.24 )-7-( -11.24 ▁28% -11.2404 ▁6.69 -11.2404 ▁id -11.2409 dihydroquinoline -11.2412 -[3-( -11.2416 ▁8.42 -11.2419 ▁satd -11.2422 ▁(1.44 -11.2423 pentanoate -11.2428 ▁8.43 -11.2453 chlorobenzoyl -11.2455 ▁1-(1- -11.2457 ▁3% -11.2458 [2- -11.2462 dioxolane -11.2462 epoxy -11.2464 Biotage -11.2467 =3.0 -11.2476 ▁(480 -11.2477 ethylsulfanyl -11.2477 ▁black -11.2478 (2-(2- -11.248 ▁(1.60 -11.2487 ▁(40.0 -11.2494 =2.6 -11.2496 ▁process -11.2497 ▁8.46 -11.2501 ▁solidified -11.2503 ▁15.5 -11.2505 ▁112 -11.2509 methoxybenzene -11.2509 ▁five -11.2509 ▁According -11.2515 carbonate -11.2522 -5,5- -11.2524 ▁variations -11.2534 ▁4.64 -11.2535 [2-(2- -11.2535 ▁dimethoxyethane -11.2539 ▁44%). -11.254 ▁(122 -11.2545 ▁0.013 -11.2559 imidazolidin -11.256 ▁trituration -11.2561 ▁sieves -11.2561 dichlorobenzyl -11.2564 ▁introduced -11.2565 ▁8.37 -11.2569 ▁II -11.2578 ▁8.56 -11.2579 86 -11.2587 methylimidazo -11.2587 oxopropan -11.2593 ▁calcium -11.2594 ▁95:5 -11.2597 )-1,3,5- -11.2599 [( -11.2602 ▁CDI -11.2606 77 -11.2608 ▁8.47 -11.2612 azabenzotriazol -11.2628 ▁8.49 -11.2639 +] -11.2642 ▁(1.33 -11.2642 fluoroaniline -11.2645 ▁non -11.2649 ▁4.67 -11.2653 Ar -11.2659 ▁fitted -11.266 ▁4.49 -11.2661 ▁(13.0 -11.2665 ▁4.59 -11.2666 ▁Br -11.2669 ((1- -11.2682 ▁Analysis -11.2683 ▁slightly -11.2688 ▁5.10 -11.2689 -2.7 -11.2693 enoyl -11.2699 ▁4.70 -11.2703 ▁temp -11.2703 ▁(117 -11.2712 ▁(195 -11.2713 3/ -11.272 ▁9.1 -11.2727 ▁-70° -11.273 ▁β -11.2732 ▁subtitle -11.2734 ▁TBTU -11.2735 ▁Mp -11.2737 Hexanes -11.2739 ▁8.54 -11.2744 ▁few -11.2745 ▁6.64 -11.2749 ▁86% -11.2753 ]-2-( -11.2755 ▁4.63 -11.2757 ▁8.51 -11.2763 chlorophenoxy -11.2765 fluoropyridine -11.2767 ▁Hexane -11.2767 ▁8.41 -11.2767 -[(3 -11.277 )-5-(3- -11.2771 ▁decanted -11.2779 ▁42%). -11.2794 ▁33% -11.2796 ▁(1.55 -11.28 )-4,5,6,7- -11.2805 ▁(370 -11.2805 aminopyridin -11.2809 ▁5.15 -11.2811 ▁6.55 -11.2824 ▁work -11.2833 ▁orthoformate -11.2836 3: -11.2837 ▁230 -11.2839 ▁(155 -11.284 ▁(1.11 -11.284 ▁135 -11.2841 ▁14.0 -11.2843 56 -11.2846 {3- -11.2854 ▁4.56 -11.2864 ▁8.52 -11.287 [(5- -11.2871 ester -11.2875 benzoxazole -11.2877 ▁2-(4-( -11.288 ▁(1.43 -11.2882 61 -11.2884 ▁30.0 -11.2885 ethylsulfonyl -11.2894 ▁15.6 -11.2899 ▁LDA -11.2899 ▁48% -11.29 LCMS -11.2916 ▁(0.030 -11.2923 ▁matter -11.2928 ▁13.9 -11.2934 ▁isothiocyanate -11.2946 ▁111 -11.2949 ▁14.3 -11.2958 ▁114 -11.2961 Q -11.2961 bromide -11.2963 ▁38%) -11.2965 -[1-( -11.2971 ▁4'- -11.2972 ▁(1.56 -11.2977 ▁(11.4 -11.2984 ▁6.00 -11.2984 dioxido -11.2986 ▁(7.9 -11.2991 ▁coupled -11.2991 =1.4 -11.2993 ▁22° -11.3007 ▁trichloride -11.3008 04 -11.301 76 -11.3012 ▁(1.42 -11.3015 -(2,6- -11.302 ▁14.2 -11.3021 ▁isomers -11.3022 meth -11.3022 ▁5.25 -11.3026 ▁Chloroform -11.3028 )-1-(5- -11.3038 ▁9.9 -11.3038 ▁6.63 -11.304 ▁part -11.305 ▁MICROWAVE -11.305 -[2-(2- -11.3056 ▁(1.19 -11.3066 trimethoxy -11.3072 ylcarbonyl -11.3092 ▁5.05 -11.3092 phosphonic -11.3093 ▁titanium -11.3102 W -11.3103 ▁dust -11.3104 -[(4- -11.3107 71 -11.3107 -3(4 -11.3111 ▁4.68 -11.312 ▁4.61 -11.3121 ×10 -11.3133 ous -11.3134 ▁6,7- -11.314 ▁(0.075 -11.3149 -5-(1- -11.315 )-9- -11.3154 methylcyclohexyl -11.3155 ▁(100% -11.3156 ▁4.57 -11.3157 ▁Re -11.3162 ▁(1.46 -11.3165 isonicotinic -11.3169 ▁13.7 -11.3176 λ -11.3179 )-4,4- -11.3179 ▁contents -11.3184 ▁aldehyde -11.3187 ▁Cl -11.319 ▁6.61 -11.3191 ▁117 -11.3194 ▁113 -11.3199 ▁(11.3 -11.3201 ▁MeOD -11.3209 ▁0.004 -11.3209 ▁(127 -11.3211 ▁(132 -11.3213 89 -11.3214 -(2,2- -11.3216 ▁4.76 -11.3222 *) -11.3223 ▁125° -11.3233 aldehyde -11.3235 ▁78% -11.3243 ▁0.006 -11.3254 butanamide -11.3258 quin -11.3262 0/1) -11.3268 ex -11.3268 ▁(11.8 -11.3276 ▁coupling -11.3277 ▁(10.7 -11.3278 ▁89% -11.3299 (4-(2- -11.33 [3- -11.3308 ▁200° -11.331 ▁6-(3- -11.3311 =8.4, -11.3312 7.35 -11.3315 ▁benzylamine -11.3316 -1-(1- -11.3316 hydroxybenzoate -11.3323 ▁[2- -11.3323 ▁8.58 -11.3324 =1.3 -11.3326 ▁(1.80 -11.3328 ▁chilled -11.3329 -3-(( -11.333 ▁(0.1% -11.333 ▁88% -11.333 ▁warming -11.3331 ▁phenylboronic -11.3338 ant -11.3341 -3-(5- -11.3343 ▁4.95 -11.3355 ▁(1.29 -11.3355 ▁(3×30 -11.3359 ▁108 -11.3359 ▁35%). -11.3367 ▁2-[ -11.3379 ▁initially -11.3384 ▁92% -11.3388 ▁6.58 -11.3389 ▁0.016 -11.339 ylsulfonyl -11.3393 ▁4-(4,4,5,5- -11.3393 ▁4.85 -11.3399 =0.9 -11.3405 91 -11.3408 ▁whole -11.3414 ▁KHSO -11.3417 -5′- -11.3418 ▁0.014 -11.3419 ▁6.45 -11.3419 ▁8.60 -11.342 for -11.3422 ▁agent -11.3432 ▁(123 -11.3433 )-2-(1- -11.3439 ▁6.57 -11.3445 un -11.3453 ▁U -11.3454 ethylthio -11.3457 ▁(0.035 -11.3458 ▁end -11.346 phenylcarbamoyl -11.3462 co -11.3466 ▁4° -11.3466 -50% -11.3467 ▁14.1 -11.3475 ▁800 -11.3479 pyrid -11.348 ▁Product -11.3487 -4,7- -11.3488 ′-( -11.3488 ▁93% -11.3489 -(2-( -11.3492 BOC -11.3493 ▁(1.54 -11.3503 ▁198 -11.3505 ▁(144 -11.3509 ▁previous -11.3511 =9.6 -11.3516 ▁DIAD -11.3526 phenylacetic -11.3528 tetrahydrobenzo -11.3531 ▁(1.57 -11.3531 ▁5.12 -11.3537 ▁9.4 -11.3539 ▁(13.2 -11.3542 ▁chloromethyl -11.3544 ▁4.73 -11.3547 =0.7 -11.3547 ▁4.72 -11.3548 [5,1- -11.3548 ▁34%) -11.3558 ▁sulphuric -11.3561 ▁(1.85 -11.3564 oxirane -11.3566 [3-(2- -11.3567 ▁36%) -11.3578 ▁4.78 -11.3579 ▁6.49 -11.358 ▁percent -11.3581 ▁Zn -11.3585 ▁Purify -11.3585 ▁precipitates -11.3591 ▁43%). -11.3594 ▁(1:1, -11.3595 ▁(11.6 -11.3599 methylenedioxy -11.36 ▁(137 -11.36 ▁(2×30 -11.3612 /0.1% -11.3616 -3,3′- -11.3618 dimethylisoxazol -11.3618 ▁(1.95 -11.362 oxoisoindolin -11.3621 ▁8.57 -11.3622 ▁144 -11.3624 ▁methanolic -11.3627 diphenylmethyl -11.363 isopropylphenyl -11.3635 ▁4.77 -11.3637 cyclohexylmethyl -11.364 7%). -11.3641 ▁short -11.3653 benzodiazepin -11.3662 ▁(440 -11.3665 ▁(185 -11.3665 ▁aromatic -11.3676 thiourea -11.3681 ▁(1.67 -11.3682 nonan -11.3691 4′ -11.3695 ▁(2.25 -11.3697 -[1-(4- -11.3709 =3.6 -11.371 -1,2,5- -11.3711 {4- -11.3713 ▁4.90 -11.3714 ▁subsequent -11.3715 ▁formation -11.3717 brown -11.3717 ▁(136 -11.3722 j -11.3726 us -11.3727 CF -11.3728 ▁(12.4 -11.3732 ▁(1.70 -11.3741 oxopyrrolidin -11.3741 ig -11.3746 ▁confirmed -11.3747 ▁39%) -11.375 ▁oxalate -11.3752 ▁phosphorous -11.3753 dien -11.3755 sulfonate -11.3759 ▁silver -11.376 ▁(0.99 -11.3762 butene -11.3769 -3,4,5,6- -11.3772 phosphoryl -11.3775 ▁(14.5 -11.3775 ▁190 -11.3786 ▁(12.6 -11.3793 ▁5.11 -11.3794 {4-[( -11.3801 ▁reversed -11.3802 ▁65% -11.3804 ▁8.53 -11.3805 ▁filtering -11.3807 ▁4.74 -11.3827 ▁(1.48 -11.3828 hr -11.3829 ▁146 -11.3833 ▁0.018 -11.384 ▁55% -11.384 ▁149 -11.3841 guanidine -11.3849 AcOEt -11.3856 ▁0.050 -11.3856 ▁(390 -11.3859 ▁Crude -11.3867 ▁Thionyl -11.3867 ▁run -11.3868 ▁126 -11.3878 ▁101 -11.3882 =0.6 -11.3884 μ -11.3888 ▁GC -11.3912 ▁15.8 -11.3913 ▁means -11.3924 methoxypyridine -11.3925 sat -11.3926 ▁32%). -11.3927 ▁(12.2 -11.3927 ▁urea -11.3932 ▁NCH -11.3937 ▁WSC -11.3938 pentafluoro -11.3939 ▁gram -11.3942 ▁whereby -11.3944 ▁(121 -11.3949 ▁EI -11.3949 ▁5.20 -11.3953 ▁(133 -11.3957 EtOH -11.396 methylphenoxy -11.3962 extracted -11.3965 ▁5.30 -11.3968 ▁41%). -11.3968 ▁17.5 -11.3972 ▁(430 -11.3986 Dimethylamino -11.3987 dioxin -11.3989 methoxyphenoxy -11.3999 ▁phosphine -11.4001 ethylcarbamate -11.4002 hi -11.4003 ▁81% -11.4009 ▁165 -11.4012 ▁4.66 -11.4015 ▁(14.0 -11.4017 ▁6.50 -11.4018 ▁72% -11.402 ▁0.024 -11.4021 ▁present -11.4025 4( -11.4031 ▁4.69 -11.4033 ▁became -11.4034 ▁DCC -11.4037 chloropyrimidine -11.4037 ▁(198 -11.4038 ▁There -11.4042 -{2- -11.4042 ▁139 -11.4049 ▁(1.31 -11.4053 +1); -11.4055 ((4- -11.4056 tin -11.4058 ▁(124 -11.406 thiazolyl -11.4063 =0.5 -11.4064 ▁consumed -11.4066 ▁Part -11.4066 ▁(134 -11.4068 )-3-(5- -11.407 ▁pinacol -11.4078 piperidone -11.408 ▁4.71 -11.4083 ▁107 -11.4086 ▁6.59 -11.4088 ▁(40% -11.4088 ▁14.6 -11.409 ▁than -11.409 ▁82% -11.409 ▁(0.040 -11.4092 )-( -11.4092 ][1,2,3] -11.4099 ▁148 -11.4103 yloxymethyl -11.4104 dihydroimidazo -11.4104 methylidene -11.4104 =4.7 -11.4106 column -11.4107 elution -11.4114 ▁8.59 -11.4115 -3-[( -11.4122 -7-(4- -11.4125 ▁(15.5 -11.4126 ▁5.18 -11.4131 ▁4.51 -11.4138 ▁autoclave -11.4144 te -11.4146 ▁8.61 -11.4147 ▁16.8 -11.415 oxazolidine -11.415 ▁dichlorobis -11.4155 ((1 -11.416 ▁slow -11.416 ▁(˜ -11.4169 ▁respectively -11.417 (2-(( -11.4174 ▁109 -11.4179 ((4-( -11.4193 -5(4 -11.4195 phenylpropyl -11.4198 ▁Prepare -11.4201 ▁consumption -11.4203 ▁16.0 -11.4204 ▁3-[( -11.421 hexa -11.421 ▁270 -11.4218 ▁obtaining -11.4219 form -11.423 ▁(131 -11.4236 malonic -11.4236 ▁Xantphos -11.4238 ▁(10.9 -11.4243 -9-( -11.4246 ▁6.53 -11.425 )-3-[( -11.4253 ▁outline -11.4256 ▁Dry -11.4261 7.25 -11.4265 toluenesulfonate -11.4272 400 -11.4274 ▁0.026 -11.4276 -2-[( -11.4282 oxycarbonyl -11.4283 ▁2-[( -11.4285 ▁15.4 -11.4288 ▁adduct -11.4295 ▁6.52 -11.4308 hydrazinyl -11.4309 ▁sulfonyl -11.4311 )-3-(1- -11.4319 and -11.4326 ▁tributyl -11.4326 ▁green -11.4328 ∼ -11.433 ▁0.007 -11.4335 ▁5-(5- -11.434 ▁platinum -11.4344 ▁(1.47 -11.4349 op -11.4354 ▁(142 -11.4356 ▁87% -11.4357 ▁hydroxyl -11.4361 cyclopropylamino -11.4366 -[2-(4- -11.4366 hexanoate -11.4368 ▁50.0 -11.4376 saturated -11.4385 ▁(+) -11.4395 .4%). -11.4397 ▁color -11.4397 ▁91% -11.4399 -2,7- -11.4404 ▁thermometer -11.4409 ▁8.65 -11.441 ▁8.62 -11.441 ▁(13.8 -11.4413 ▁(129 -11.4415 ▁raised -11.4416 ▁NaNO -11.4416 em -11.4423 BrN -11.4427 =10 -11.4433 {[(2 -11.4435 ▁ethereal -11.4436 ▁−60° -11.4442 " -11.4454 ▁(13.6 -11.4456 > -11.4458 ▁any -11.446 ▁PE -11.4461 ▁8.64 -11.4462 ▁(1.58 -11.4463 ▁(12.8 -11.4465 [4-(5- -11.4467 -[(2 -11.4468 ℓ -11.4473 ▁6.56 -11.4475 7.38 -11.4475 ▁119 -11.4475 ▁those -11.4476 ▁(1.63 -11.4477 Trifluoromethyl -11.4479 fluorophenol -11.4482 solvent -11.4488 ▁homogeneous -11.4496 ▁6.54 -11.4497 ▁106 -11.4513 ▁6.48 -11.4518 potassium -11.4521 ▁[(1 -11.4522 ▁has -11.4523 ▁4.83 -11.4536 ▁(11.7 -11.4537 ▁(162 -11.4543 ▁dissolving -11.4544 ▁pink -11.4544 paraformaldehyde -11.4545 ▁within -11.455 azulene -11.4553 ▁0.075 -11.4557 ethylidene -11.4558 -6-(1- -11.4559 sulfonylamino -11.456 -[4-(3- -11.456 zinc -11.4563 ▁(3×) -11.4563 thiopyran -11.4589 ▁4.82 -11.459 ▁3-[ -11.4602 ▁balloon -11.4602 ▁280 -11.4603 ▁(0.150 -11.4606 carbazol -11.4607 10° -11.4609 isoxazolyl -11.461 =1.1 -11.4611 ▁(103 -11.4613 ▁(1.66 -11.4623 ▁MeI -11.4628 benzhydryl -11.4631 {[3-( -11.4633 heptyl -11.4634 methylbenzo -11.4638 ▁(109 -11.4642 aminocarbonyl -11.4644 ▁(11.1 -11.4645 ▁0.017 -11.4647 ▁33%). -11.4649 ▁bs -11.4654 ▁thio -11.4654 ▁0.008 -11.4655 ▁> -11.4659 ×30 -11.466 ▁DIBAL -11.4667 ▁MPLC -11.4667 ▁25%). -11.4668 =8.0, -11.467 ▁(1.68 -11.4679 ▁0.035 -11.4685 ▁(1.64 -11.469 ▁14.8 -11.4692 ▁16.4 -11.4694 ▁9.7 -11.4695 ▁(147 -11.4697 ▁(1.76 -11.47 ((( -11.47 [5.5] -11.4701 ▁(1.52 -11.4704 6%). -11.4706 ₃) -11.4713 ▁(119 -11.4715 ▁15.7 -11.4718 cyclohepta -11.4718 propionitrile -11.472 ▁1,1,1- -11.4729 ▁Obtained -11.4736 ▁Tetrakis -11.4736 ▁concentrating -11.4743 -(3-( -11.4753 ▁MP -11.4757 ▁sulfur -11.4768 ▁stripped -11.4771 ▁138 -11.4772 ▁77% -11.4773 ▁330 -11.4773 propen -11.4774 ▁Ac -11.4774 ▁155 -11.4788 ▁22.5 -11.4791 ▁Gradient -11.4794 ▁(1.62 -11.4798 ▁(2×25 -11.48 ×100 -11.4802 (6,7- -11.4806 ▁Dimethyl -11.4808 )-6-(2- -11.4812 ▁37%) -11.4812 ▁4.84 -11.4814 }-1,3- -11.4815 -(2,2,2- -11.4815 7.36 -11.4816 ▁8.69 -11.4817 ▁(146 -11.4821 ▁(12.3 -11.4841 fluoromethyl -11.4843 ▁4.88 -11.4848 ▁(9.9 -11.4849 ▁0.011 -11.4856 cyclohexyloxy -11.4859 ▁(0.060 -11.4859 ▁(158 -11.4862 ▁8.75 -11.4864 butylamino -11.4867 ▁(1.39 -11.4872 (2-(3- -11.4875 ▁BINAP -11.4882 picolinic -11.4883 ▁Flow -11.489 PrOH -11.4893 ▁LiCl -11.4894 ▁5.23 -11.4902 ▁0.022 -11.4906 ▁prepare -11.4907 ▁hydro -11.4913 {[(4- -11.4914 ▁6.51 -11.4918 ▁partially -11.4918 ▁(16.0 -11.4922 ▁para -11.4923 dimethylsilane -11.4924 ▁16.2 -11.4929 isothiazol -11.4931 ▁4% -11.4931 ▁115° -11.4931 ▁agitated -11.4932 hydroxypropan -11.4933 )-(4- -11.4938 ▁450 -11.4938 ▁175 -11.4943 ▁260 -11.4946 =3.2 -11.4954 ▁anisole -11.4957 ((2 -11.4964 ,5- -11.4969 ▁5.17 -11.497 ▁6.40 -11.4973 ▁Pyridine -11.4974 ▁(148 -11.4975 ▁[4- -11.498 ▁104 -11.4981 methoxybenzoate -11.4983 ▁(1.41 -11.4984 ▁(1.53 -11.4991 /5 -11.4991 act -11.4992 methylsulfinyl -11.4995 ▁when -11.4995 oxazepine -11.4998 ▁4.92 -11.5006 fluorobenzoate -11.5007 ▁14.7 -11.5007 =3.5 -11.5011 ▁standard -11.5017 ▁4.79 -11.5017 =8.8, -11.5021 ▁(376 -11.5023 -2-(6- -11.5026 ▁15.2 -11.5027 phosphate -11.5027 quantitative -11.5037 ▁evacuated -11.5038 ▁(0.045 -11.5043 ▁Stirring -11.5045 methylpyrimidine -11.5046 ▁dissolve -11.5049 ▁(520 -11.5052 ▁borate -11.5058 ▁batch -11.506 ▁5.08 -11.5066 ▁6.46 -11.5071 {5- -11.5081 ▁-5° -11.5086 ▁5.02 -11.5088 ▁(0.012 -11.5092 idine -11.5094 ▁cream -11.5096 ▁NEt -11.5104 ▁alumina -11.5106 ▁¹ -11.5109 ▁NaHSO -11.5113 benzoxazin -11.5113 picolinate -11.5117 ▁136 -11.5118 ap -11.5121 ▁KOAc -11.5122 ▁etherate -11.5122 ▁6.47 -11.5125 ▁(410 -11.513 ▁(196 -11.513 ▁20%). -11.5132 rac -11.5134 ▁(167 -11.514 ▁reach -11.5145 ▁0.028 -11.5147 ▁polar -11.5148 ▁5.14 -11.5153 acetoxymethyl -11.5156 quinolinyl -11.5157 ▁25.0 -11.516 ▁5.07 -11.5161 ▁(12.1 -11.5162 ▁6.44 -11.5162 ▁17.4 -11.5165 isobutylaluminum -11.5166 ▁Solid -11.5168 ▁condensed -11.5168 per -11.5168 ▁(2×200 -11.5168 ▁5.22 -11.5169 Y -11.5171 ▁8.70 -11.5178 ▁1000 -11.5178 triisopropylsil -11.5184 ▁UPLC -11.5194 ▁31%). -11.5195 ▁(460 -11.5201 ▁BOP -11.5201 ▁mechanical -11.5203 [5-( -11.5207 ▁(12.7 -11.5215 ▁— -11.5215 [2-( -11.5217 ▁4.86 -11.5222 sulfinyl -11.5224 -[4-(4- -11.5225 ▁19.5 -11.5226 (4,5- -11.5226 -[2-(3- -11.5229 ▁5.35 -11.5235 ▁0.023 -11.524 ▁2,2′- -11.5244 ▁8.66 -11.5247 08 -11.5247 ▁5.16 -11.5248 ▁8.68 -11.5249 ▁cyclohexyl -11.525 %. -11.5251 ▁5.26 -11.5255 ▁(16.5 -11.5255 isopropylpropan -11.5257 ▁5.24 -11.5257 phenylsulfanyl -11.527 ▁(143 -11.5274 syn -11.5275 ▁0.032 -11.5278 -15 -11.5284 =9.5 -11.5286 −1) -11.529 lutidine -11.5291 ▁76% -11.5295 oxymethyl -11.5304 ▁indole -11.5305 ethylcarbamoyl -11.5305 ▁(0.013 -11.5306 -7-(3- -11.5307 94 -11.5307 ▁5.28 -11.5309 ▁On -11.5313 ▁5.09 -11.5315 ▁3,6- -11.5323 =40 -11.5326 ▁170° -11.5331 ▁5.19 -11.5331 ▁powdered -11.5332 ▁bed -11.5334 ▁freshly -11.5338 adamantan -11.5338 ▁mbar -11.5343 ″ -11.5345 ▁700 -11.5346 ▁(470 -11.5348 ▁OH -11.5348 ▁5.13 -11.5351 mp -11.5359 ▁(197 -11.5359 ▁(17.5 -11.5363 Rf -11.5375 ▁2-(1 -11.5375 ▁hydrazide -11.5378 -1.5 -11.5379 ▁phthalimide -11.5388 li -11.5391 ▁8.67 -11.5392 ▁Cool -11.5397 ▁(1.74 -11.5399 ▁4.98 -11.5404 ▁8.63 -11.5408 ▁(1.49 -11.541 dichlorobenzene -11.5411 ▁0.036 -11.5416 -[4-(2- -11.5417 ment -11.5421 -2-(( -11.5421 ▁(215 -11.5428 benzodioxin -11.543 ▁Acetonitrile -11.5434 ▁18.5 -11.5437 HRMS -11.5443 ▁84% -11.5445 ▁frit -11.5446 ▁(1.78 -11.5447 -{3- -11.5448 ▁5.04 -11.5449 ethylene -11.5449 bromobenzyl -11.545 ▁0.019 -11.5452 ▁5.03 -11.5455 ▁147 -11.5457 ▁0.045 -11.5457 2.00 -11.5459 hydroxyethoxy -11.5461 chloropropyl -11.5464 ▁determined -11.5466 phthalimido -11.5469 ▁(3× -11.5473 trifluorophenyl -11.5473 ▁Tetrahydrofuran -11.5484 -[6- -11.5491 =8.5, -11.5495 ▁100:0 -11.5501 ylsulfanyl -11.5503 ▁15.3 -11.5503 ▁ddd -11.5505 methano -11.5505 ▁127 -11.5505 acetylene -11.551 ▁16.6 -11.5511 ▁Oxalyl -11.5513 8%). -11.552 ▁LAH -11.5522 -4-[( -11.5523 benzophenone -11.5529 ▁(15.6 -11.5536 ((5- -11.5539 =0.4 -11.5543 ▁137 -11.5549 Acetyl -11.5549 ▁FCC -11.555 ▁(166 -11.5558 ▁dt -11.5567 ▁16.3 -11.5568 ally -11.557 3-(4,4,5,5- -11.557 [4-( -11.5576 ▁(0.300 -11.5583 ▁26%). -11.5586 ▁0.055 -11.5588 Butyllithium -11.5589 azepan -11.5605 ▁83% -11.5605 ▁quench -11.5608 indeno -11.5609 ▁4.97 -11.5616 ▁(2.20 -11.5617 ▁(168 -11.5619 ▁128 -11.5628 ▁Hydrogen -11.5634 ▁5.21 -11.5636 ▁analogously -11.5638 ▁71% -11.5643 /10 -11.5643 -1(3 -11.5644 tributylstannyl -11.5645 {4-[ -11.565 =12 -11.5654 iodobenzene -11.5667 ▁thoroughly -11.568 ▁(151 -11.5683 ▁4.87 -11.5692 ▁0.020 -11.5693 (4-(5- -11.5696 =4.6 -11.5698 tt -11.57 triphenylmethyl -11.5701 ▁(102 -11.5703 ▁7-(4- -11.5704 chloroformate -11.5706 ▁(1.90 -11.5709 oxobutanoate -11.571 ▁2′- -11.5711 ▁alkaline -11.5718 solid -11.5719 ▁Ltd -11.5721 ▁4.81 -11.5723 ▁(560 -11.5726 ▁6.25 -11.5727 ▁118 -11.5736 ph -11.5737 ▁periodate -11.5737 ▁0.033 -11.5738 07 -11.5742 dihydrothieno -11.5742 ▁(0.018 -11.5742 ▁(1.51 -11.5749 ▁143 -11.5754 ▁remov -11.5754 ▁4.96 -11.5755 ▁isohexane -11.5756 ▁8.72 -11.576 )-3,6- -11.5761 ▁(1.73 -11.5762 ▁yields -11.5763 ▁8.73 -11.5766 ▁little -11.5779 pyridinium -11.5781 ▁Dissolve -11.5787 isopropylamino -11.5788 benzocyclohepten -11.5792 ▁derivative -11.5794 esium -11.5795 {3-[( -11.5799 ]-2′(1′ -11.5802 ▁0.034 -11.5802 -4-(( -11.5804 [4-(6- -11.5806 ×50 -11.581 ▁(0) -11.5817 hydrochloride -11.582 ▁precipitation -11.5827 [(4- -11.5834 ▁(0.022 -11.5837 ▁sulfonic -11.5837 thione -11.584 ▁(14.2 -11.5846 ▁HCI -11.5849 ▁mother -11.5856 crown -11.5864 ▁4.99 -11.5864 sil -11.5867 -1′- -11.5868 64 -11.5871 ▁121 -11.5881 -{1- -11.5882 ×20 -11.5883 ▁17.6 -11.5885 ▁diastereomers -11.5885 ▁(25% -11.5886 ▁(1.86 -11.589 isopropoxyphenyl -11.5893 40° -11.5895 ][1,2] -11.5895 thiomethyl -11.5905 -5-(5- -11.5909 ▁objective -11.5911 {[2- -11.5913 critical -11.5915 Dihydro -11.5921 ▁27%). -11.5922 ▁kPa -11.5926 ▁(2.05 -11.5933 ▁(530 -11.5934 =3.3 -11.5934 benzodioxol -11.5935 -(4-(2- -11.5936 ▁0.027 -11.5938 =30 -11.5941 ▁(0.016 -11.5941 ▁providing -11.5942 ▁structure -11.5942 ▁some -11.5943 ▁129 -11.5947 ▁90:10 -11.5951 butyldiphenylsil -11.5956 acryloyl -11.5959 ▁8.80 -11.5959 ▁(100%) -11.596 ▁5.06 -11.5967 ▁0-50% -11.5968 ▁fashion -11.5973 7.39 -11.5979 ▁0.009 -11.5982 ]-3-( -11.5984 ▁21%) -11.5989 ▁heptanes -11.5995 ▁ethylamine -11.5996 hydrochloric -11.5999 ▁Ether -11.6005 ▁5.29 -11.6007 ▁4.93 -11.6008 (4'- -11.6009 ▁(540 -11.6012 ▁5.40 -11.6016 ▁124 -11.6018 ▁6.42 -11.6019 [(3- -11.6019 ▁(1.72 -11.6021 ▁15.9 -11.6023 =1:1) -11.6032 ▁14.9 -11.6034 ▁liquor -11.6036 7.34 -11.6036 lu -11.6037 ▁broad -11.6042 Isopropyl -11.6049 ▁(141 -11.6049 ▁[1 -11.6053 ▁197 -11.6056 0:1) -11.6058 ▁(1.88 -11.6064 ive -11.6067 nicotinaldehyde -11.6068 ▁63% -11.6082 ▁4.89 -11.6087 [(6- -11.6091 (4-(( -11.6093 =8.3, -11.6094 ▁glycine -11.6095 COOH -11.6096 ▁diethylamine -11.6099 ▁mCPBA -11.61 ▁(156 -11.6101 ▁chiral -11.6103 ▁use -11.6108 ▁6.35 -11.6109 ▁4,4, -11.6112 ▁15.1 -11.6113 phenylphosphoryl -11.6114 chromeno -11.6123 Martin -11.6125 ▁(139 -11.6126 cyclopentyloxy -11.6127 ox -11.6132 methoxybenzoyl -11.6132 ▁5.32 -11.6137 nitrobenzoyl -11.6144 ▁completely -11.6154 benzoyloxy -11.6158 ▁4.94 -11.6162 benzenamine -11.6164 )+] -11.6168 (1-(2- -11.617 ▁(0.080 -11.6179 ▁173 -11.6179 -8-( -11.6181 -2,4,6- -11.6182 [1-(4- -11.6182 {6- -11.6187 {[4- -11.6192 penta -11.6198 03 -11.6199 ▁NaOMe -11.62 anisole -11.6207 ▁most -11.6207 ▁195 -11.6207 ▁(0.024 -11.6214 ▁SONICATE -11.6219 ▁0.038 -11.6223 hydro -11.6228 ▁ul -11.6229 -10% -11.6231 ▁(0.070 -11.6234 ▁6.43 -11.6241 ▁0.100 -11.6241 ▁(0.023 -11.6247 ▁filtrates -11.6256 ▁19.6 -11.6256 -[(3- -11.6257 ▁inlet -11.6258 ▁168 -11.6261 ▁19.2 -11.6269 (3-( -11.6269 ▁0.021 -11.6272 -5-[4-( -11.6273 =4.2 -11.6276 ▁5.01 -11.6283 ▁(1.82 -11.6285 -17 -11.6286 ▁5.38 -11.6287 ▁carbamate -11.6292 carbonyloxy -11.6297 propionylamino -11.6302 ▁(6.00 -11.6308 ▁shown -11.6308 ▁40.0 -11.6309 eq -11.6312 45° -11.6312 llowing -11.6313 octamethyl -11.6317 -1-(5- -11.6321 ▁0.037 -11.6326 ▁(1.84 -11.6327 ▁sonicated -11.6332 ▁cyano -11.6333 lo -11.6342 —(( -11.635 ▁(214 -11.6355 ▁(176 -11.6358 ▁adsorbed -11.6368 styryl -11.6373 ▁(11.9 -11.6375 ClF -11.6377 ▁(0.028 -11.6377 [3-(3- -11.6379 AB -11.6379 ▁172 -11.6386 ▁< -11.6386 ×150 -11.6387 -{4- -11.6387 300 -11.6388 2.10 -11.6393 (1-(4- -11.6393 -{ -11.6395 ▁With -11.6398 ▁(178 -11.6402 ▁(188 -11.6405 benzylthio -11.6406 ▁4.91 -11.6411 Oxo -11.6414 ▁5-(1- -11.6416 ▁(12.9 -11.6418 ▁(10.00 -11.6419 all -11.6422 7.32 -11.6425 ▁KI -11.6425 dissolved -11.6428 yne -11.643 2,3,4,9- -11.6432 isoindolin -11.6433 ▁pooled -11.6447 (+) -11.6449 ▁rapidly -11.6455 Phos -11.6456 ▁(0.055 -11.6456 7.15 -11.6456 ▁(0.017 -11.6456 ▁8.71 -11.6457 1,3,4,5- -11.6458 ▁135° -11.646 ▁(13.3 -11.6461 74 -11.6462 -1,3,8 -11.6464 ▁(0.005 -11.6473 5′ -11.6474 ▁(14.4 -11.6476 -[2-(5- -11.6476 ▁0.046 -11.6477 ▁{ -11.6481 -4-(1 -11.6486 ▁(60.0 -11.6487 ▁(174 -11.6493 ▁123 -11.6496 ▁6.38 -11.6499 )−. -11.6499 ▁azeotroped -11.6502 ▁(1.92 -11.6507 ▁(153 -11.6511 ▁pyridin -11.6514 quinolizine -11.6514 ▁Org -11.6517 +: -11.6517 phos -11.6524 100% -11.6525 ▁24%). -11.653 {[3- -11.653 =25 -11.6532 ▁previously -11.6532 ,14 -11.6533 ▁workup -11.6538 ▁29%). -11.6538 ▁replac -11.654 thiazin -11.6541 chlorobenzene -11.6544 ]-3 -11.6546 ▁Hydrazine -11.6554 ▁28%) -11.6555 7.37 -11.6561 ▁20-25° -11.6563 bipyridin -11.6564 ▁(14.3 -11.6564 ▁Concentrated -11.6567 ▁(15.2 -11.657 ▁Bis -11.6571 }-6- -11.6579 ▁(163 -11.658 ▁# -11.6583 ▁(2.15 -11.6603 formylphenyl -11.6604 ▁Parr -11.6604 ▁amber -11.6604 oxazinan -11.6605 -1,7- -11.6605 evaporated -11.6609 oxan -11.6621 ▁(199 -11.6623 dry -11.6623 ▁68% -11.6624 ▁quant -11.6624 ▁45% -11.6625 ▁8.76 -11.6626 ▁piperidin -11.6628 dimethylpropyl -11.6629 ▁(0.032 -11.663 ▁(2.10 -11.6634 ▁Argon -11.6638 isonicotinamide -11.6642 difluoroethyl -11.6646 ▁AlCl -11.6653 phenylacetate -11.6656 ▁0.065 -11.6656 ef -11.6656 dibromoethane -11.6657 µ -11.666 5.00 -11.6666 ▁8.78 -11.6671 ▁Phenyl -11.6674 dihydrofuran -11.6675 1.20 -11.6677 -(2,3- -11.6677 ▁(0.014 -11.6681 tBu -11.6681 oxazolo -11.6681 ▁142 -11.6682 ▁(2.75 -11.6684 1.25 -11.6685 09 -11.6693 =0.3 -11.6693 ▁134 -11.6697 ite -11.6706 ▁(157 -11.6706 ▁0-20% -11.6707 ▁worked -11.6707 -1-(( -11.6708 ▁5.34 -11.6709 −1; -11.6711 ▁1-[ -11.6716 [[( -11.6717 with -11.6719 ▁(850 -11.672 (4-( -11.6721 ▁(100.0 -11.6724 =1:1 -11.6729 ▁141 -11.673 ▁−50° -11.673 io -11.6731 oxiran -11.6731 [(1 -11.6732 ▁285 -11.6734 ▁replaced -11.6734 ▁17.8 -11.6738 ▁79% -11.6738 ▁Wash -11.6739 -80% -11.674 ▁17.2 -11.6741 aminothiazol -11.6743 =2.9 -11.6743 chlorosulfonyl -11.6747 ating -11.6747 ▁capped -11.6747 ▁major -11.675 ▁(1.83 -11.675 ▁dioxan -11.6753 ++ -11.6754 phthalic -11.6756 cm -11.6757 ▁condition -11.6757 ▁(0.033 -11.6758 ▁Methanesulfonyl -11.6761 ▁0.048 -11.6762 ▁thiourea -11.6764 ▁320 -11.6764 ▁volatile -11.6766 ▁(22.5 -11.6767 azo -11.6768 ▁5.31 -11.677 ▁(15.3 -11.6772 ▁196 -11.6772 ▁158 -11.6773 ▁(235 -11.6773 deoxy -11.6778 ▁hexamethyl -11.6781 ▁23%). -11.6781 ▁5.37 -11.6787 Table -11.6787 ▁(13.7 -11.6789 ▁5.27 -11.6789 ▁ESMS -11.679 chloroperoxy -11.6793 ▁separator -11.6795 ▁pump -11.6797 isocyanate -11.6804 ▁(0.026 -11.6806 dimethylaniline -11.681 ▁(0.065 -11.6816 ▁16.1 -11.6819 ▁(149 -11.6821 ethanesulfonyl -11.6827 =12.0 -11.6835 ▁(164 -11.6838 ▁73% -11.6838 ▁Fe -11.6838 ▁(14.8 -11.684 ▁conducted -11.6841 ▁Hexanes -11.6842 (2′- -11.6844 ▁340 -11.6848 ▁may -11.6855 ▁chloroacetyl -11.6856 )-4,6- -11.6856 ▁5.50 -11.686 carb -11.6864 [2-(4- -11.6866 ▁159 -11.687 ″- -11.6872 ▁TBME -11.6875 ▁away -11.6875 ]-2,2- -11.6878 ▁(275 -11.6879 butyldicarbonate -11.6883 apci -11.6884 ▁(1.59 -11.6892 ▁(2.45 -11.6892 ▁bisulfite -11.6892 ▁exchange -11.6893 -[3-(2- -11.6895 phenylethynyl -11.6897 ▁16.7 -11.69 [4-(4- -11.6901 ▁(1.77 -11.6902 {(1 -11.6908 ▁Med -11.6909 ▁0.044 -11.6919 ted -11.6921 [3-(4- -11.6929 ▁169 -11.6935 ▁5.85 -11.6938 ▁(580 -11.694 ▁(13.4 -11.6942 ▁(1.61 -11.6946 ▁3,4,5- -11.6948 imido -11.695 {(2 -11.6952 picolinamide -11.6954 ▁(2.35 -11.6958 6-(4,4,5,5- -11.696 ▁Inc -11.6961 ▁133 -11.6964 ▁62% -11.6964 ,5,6- -11.6969 ▁(0-100% -11.697 ▁0.010 -11.6973 ▁(14.7 -11.6975 ▁remained -11.6979 ▁(154 -11.6979 -[(1- -11.6981 Pr -11.6982 ▁(18.5 -11.6986 chlor -11.6986 ▁ceased -11.6987 ▁25-30° -11.6987 ▁0.058 -11.6988 isothiocyanato -11.6989 ▁(490 -11.6989 ▁(1.94 -11.699 ▁21.2 -11.6992 )-6-(3- -11.6997 product -11.7003 indane -11.7005 ▁Lawesson -11.7005 cyclohexylamino -11.7007 -2′ -11.7014 ▁con -11.7016 butanoyl -11.7018 ▁5.36 -11.702 ▁(0.250 -11.7023 ]-2 -11.7026 ▁5.33 -11.7028 ill -11.7032 -40% -11.7036 ▁phosphoryl -11.7037 =8.2, -11.7044 -60 -11.7045 ▁(1.87 -11.7046 ▁(205 -11.7046 ▁5.75 -11.7048 ▁8.74 -11.7049 nitrobenzyloxy -11.705 oxopentanoate -11.7057 ▁intensity -11.7057 ▁content -11.7065 quinolyl -11.7065 ▁dropping -11.7066 glucopyranosyl -11.7066 ot -11.7074 ▁18.6 -11.7074 ▁immediately -11.7074 ▁122 -11.708 ▁6.39 -11.7082 ▁47% -11.7098 =24 -11.7101 ▁(18.0 -11.7101 7.10 -11.7103 ▁(1.96 -11.7106 benzoxazine -11.7107 ▁(1.98 -11.7107 ▁methods -11.7109 ▁(192 -11.7111 piperidino -11.7111 bS -11.7112 -60% -11.712 1.15 -11.7123 ▁benzo -11.7124 ▁360 -11.7124 {( -11.7126 ▁SnCl -11.7127 +1)+ -11.713 fluorene -11.7131 -1′ -11.7132 la -11.7137 ▁[(3 -11.7141 ▁6.36 -11.7141 ▁mmHg -11.7145 −) -11.7148 -((3- -11.7151 )-2-(6- -11.7161 ▁cuprous -11.7162 ▁19.7 -11.7164 -8,9- -11.7173 ▁Purity -11.7179 ▁66% -11.7181 ▁hydrogenation -11.7183 ▁(173 -11.7186 develop -11.7187 ▁(152 -11.7191 benzazepin -11.7194 ▁slurried -11.7198 ▁8.77 -11.7205 ▁(0.021 -11.7213 ▁(325 -11.7214 ▁6.37 -11.7218 ▁3× -11.7219 ▁6.41 -11.7219 ▁chlorobenzene -11.722 ▁69% -11.7224 ▁7-(2- -11.7231 ▁(282 -11.7231 ▁where -11.7232 ▁1,5- -11.7238 ▁(14.6 -11.7244 ▁(510 -11.7249 -2-[4-( -11.7251 ▁(0.036 -11.7252 oxobutan -11.7252 ▁0.030 -11.7255 ▁(15.4 -11.7256 -[1-(2- -11.7257 -12- -11.7259 ose -11.7261 ▁(171 -11.7265 ▁(0.034 -11.7266 ▁167 -11.7266 CPBA -11.7267 ▁6.30 -11.7267 ▁57% -11.7269 ▁18.0 -11.7269 ▁Ammonium -11.7269 ▁irradiate -11.7269 ▁ee -11.7274 azidomethyl -11.7276 ▁171 -11.7276 ▁Si -11.7276 isomer -11.7286 -2( -11.7287 3.00 -11.729 ▁(1.93 -11.7293 ▁(172 -11.7295 ▁(15.7 -11.7299 000 -11.7305 methanopyrido -11.7306 ▁(2.30 -11.7308 1.00 -11.7309 ▁(13.9 -11.7309 red -11.7311 ▁74% -11.7317 {[(3 -11.7321 ▁6.32 -11.7321 ▁0.043 -11.7323 ▁90%) -11.7324 difluorophenoxy -11.7327 ▁[(2 -11.7329 ▁(1.89 -11.7331 ▁(2.16 -11.7331 ▁(177 -11.7337 ▁(0.010 -11.734 ▁detected -11.7341 9%). -11.7344 -2′,4′,6′- -11.735 =20 -11.7351 ▁8-( -11.7352 ▁5.42 -11.7354 app -11.7355 -30% -11.7356 ▁0.031 -11.7357 ▁18.4 -11.7358 ▁whereupon -11.7359 =45 -11.7363 ▁(0.011 -11.7371 amido -11.7374 ▁→ -11.7375 =18 -11.7376 • -11.7376 ▁atmospheric -11.7378 ▁cyclopentyl -11.7383 ▁225 -11.7384 ry -11.7386 [2-(3- -11.7387 ▁-15° -11.7388 acetyloxy -11.7393 ▁follows -11.7395 butylphenyl -11.7396 ▁NaI -11.7402 ▁1,2,3,4- -11.7404 -2,2,2- -11.7409 )-1,6- -11.7413 (2-( -11.7414 ▁(15.8 -11.7415 ▁8.85 -11.7416 1.40 -11.7417 iv -11.7417 ▁(2.40 -11.7421 ▁thiophene -11.7427 naphth -11.743 =38 -11.7433 iodopropane -11.7438 ▁FAB -11.7442 trimethoxyphenyl -11.7444 -[(2- -11.7446 ▁2-(7- -11.7449 6(5 -11.7449 ▁0.042 -11.7451 diene -11.7452 ▁103 -11.7454 ]-5-( -11.7458 7.31 -11.746 methylphenol -11.7461 methylquinoline -11.7466 1.10 -11.7471 methylthiazol -11.7477 ▁Heat -11.7484 ▁295 -11.7485 ▁6.33 -11.7486 ▁5,7- -11.7488 7.26 -11.7495 ▁tetrakistri -11.7497 ▁5.55 -11.7498 ▁(2.14 -11.7499 20° -11.7501 ▁(1500 -11.7501 ▁0.040 -11.7502 ▁phosphoric -11.7504 ▁(0.019 -11.7512 ▁As -11.7512 ▁constant -11.7513 [4.4] -11.7513 ▁166 -11.7514 thiazolidin -11.7518 ▁volumes -11.7518 ▁disulfide -11.7518 -3,8- -11.7523 ▁(630 -11.7531 ▁(3.50 -11.7533 ▁(1.71 -11.754 ▁5.45 -11.7541 ▁(2.08 -11.7542 ▁(2.04 -11.7543 ▁20.5 -11.7543 ▁(183 -11.7545 butylphosphino -11.7549 ▁22%). -11.7555 eluted -11.7559 benzothiophene -11.7562 ▁(161 -11.7563 ▁ν -11.7565 ▁8.81 -11.7566 ▁Dioxane -11.7566 (7 -11.7567 (5-(3- -11.7568 ie -11.7569 (5,6,7,8- -11.7572 ▁needles -11.7577 ▁0.029 -11.758 ▁67% -11.7586 ▁milliliters -11.7592 ▁9:1) -11.7594 carboximidamide -11.7595 obtained -11.7596 ▁distilling -11.7596 [1 -11.7596 ▁8.84 -11.7598 methoxyaniline -11.7599 ▁6.22 -11.7599 thien -11.7608 ▁8.82 -11.7612 decyl -11.7613 ▁Cu -11.7614 ▁95%) -11.7618 =15 -11.7619 ▁31% -11.7626 undecan -11.7626 +1), -11.7628 benzenethiol -11.7629 ]-3,4- -11.7629 ▁(0.027 -11.7632 butyldimethyl -11.7633 ▁MnO -11.7633 ++1). -11.7635 [3.3.1] -11.7642 MeCN -11.7645 ▁ret -11.7647 ▁(2.26 -11.7648 =35 -11.7654 ▁0.052 -11.7654 oxopiperidine -11.7655 if -11.7656 ▁phosgene -11.766 ▁19.4 -11.7661 ▁hold -11.7664 ▁290 -11.7666 ▁156 -11.7676 ▁132 -11.7676 [1-( -11.7679 ▁(1.69 -11.7679 ▁(13.1 -11.768 ▁DAST -11.7683 [5-(4- -11.7685 ▁(375 -11.7686 ▁propargyl -11.7686 chrysen -11.7688 ▁group -11.7688 ▁5.52 -11.7691 ▁[4-( -11.7694 ▁6.05 -11.7696 ▁98%) -11.7701 ▁(2.18 -11.7702 ij -11.7703 methylpyrazolo -11.7706 )-1,1′- -11.7706 2.20 -11.7707 ~ -11.7707 ▁5.43 -11.7711 propene -11.7721 -[(5- -11.7727 ▁till -11.7729 ▁2-(3,4- -11.773 -((2- -11.7733 ▁10:1 -11.7734 ▁trioxide -11.7735 ]( -11.7736 ▁5.88 -11.7746 -6-(5- -11.7749 06 -11.7749 {1 -11.775 able -11.7765 =8.6, -11.7765 methylbut -11.7767 dq -11.777 ▁36% -11.7775 )-(3- -11.7776 ▁(17.0 -11.7776 Tetrahydro -11.778 ▁(245 -11.7782 ▁return -11.7791 -6,8- -11.7794 )-1,1,3,3- -11.7797 aluminium -11.7801 Cyclopropyl -11.7801 [4-(2- -11.7806 ▁6.28 -11.7811 =7.8, -11.7813 ▁-30° -11.7814 =8.7, -11.7818 1.60 -11.7823 tr -11.7829 ]-4,5- -11.7832 ▁metal -11.7836 ▁(0.042 -11.7837 ▁131 -11.7838 )-3-[ -11.7839 ▁(2.65 -11.7842 ▁(1.97 -11.7845 )-1-[( -11.7846 ▁Pure -11.7848 pos -11.785 ▁6.15 -11.7855 ▁0.047 -11.7857 diazo -11.786 ▁16.9 -11.7861 ▁21.5 -11.7861 chloroacetyl -11.7863 ▁Dess -11.7867 [(2,4- -11.7869 ▁(16.6 -11.7872 7.33 -11.7873 Gly -11.7876 ▁carbonyl -11.7884 ▁Å -11.7886 )-(2- -11.789 ▁(182 -11.7894 ▁Thus -11.7895 ▁2-(2,6- -11.7898 ▁acetaldehyde -11.7899 bromobenzene -11.7903 84 -11.7903 ▁discarded -11.7904 ▁less -11.7905 7.46 -11.791 ▁(19.5 -11.7912 ▁(186 -11.7917 ▁8.83 -11.7923 6′ -11.7923 [4-(3- -11.7928 ▁salts -11.7929 35° -11.793 ,4,5,5 -11.7931 adamantyl -11.7933 ▁course -11.7933 -(4-(3- -11.7933 ▁22.3 -11.7936 ▁27% -11.794 ]-4-( -11.794 ▁(212 -11.7942 (3,3,3- -11.7942 ,6,7,7 -11.7944 ▁5.46 -11.7944 ▁(16.8 -11.7946 7.24 -11.7947 chlorosilane -11.7948 ▁(17.6 -11.7949 ▁ch -11.7953 -[2-(1- -11.7964 ▁64% -11.7967 ▁(4:1 -11.7967 30° -11.7969 ▁(0.044 -11.797 ▁24.0 -11.7973 -5,8- -11.7975 7(8 -11.7977 neopentyl -11.7981 )-4,4,5,5- -11.7981 ▁174 -11.7982 ▁0.066 -11.7986 hexafluoro -11.7988 ▁(2.55 -11.7995 2.15 -11.7996 picolinonitrile -11.8 ▁iPrOH -11.8001 ▁18%). -11.8002 1.18 -11.8004 ▁quinoline -11.8005 methylquinolin -11.8008 ▁steam -11.801 (3′- -11.8011 -6-[( -11.8017 ▁CF -11.8019 ▁Drying -11.8021 ]-1′- -11.8022 -2,4′- -11.8023 ▁XBridge -11.8024 ▁0.063 -11.8034 ▁293 -11.8035 (3-(2- -11.8037 ▁[5- -11.8048 -2-(1 -11.8048 ▁NMM -11.8049 ▁(1.79 -11.8049 ▁0.057 -11.8057 bipyridinyl -11.806 Waters -11.8062 1.50 -11.8063 ▁292 -11.8064 -[1 -11.8064 ▁washings -11.8065 Pd -11.8065 (2-(1- -11.8068 -4-(6- -11.8069 )-7,8- -11.8076 )-1-(1- -11.8077 -7.30 -11.8078 ▁0.077 -11.8078 Dioxane -11.8079 ▁25.5 -11.809 ▁17.1 -11.8093 ▁6.34 -11.8096 guanidino -11.8096 =33 -11.8096 ▁4-(1 -11.8097 ▁propyl -11.8097 -6,6- -11.8098 diazomethane -11.8099 ▁5.68 -11.8102 ▁5.76 -11.8103 ▁(2.28 -11.8103 -7-(1- -11.8109 ▁6.20 -11.8112 ▁(0.037 -11.8114 5,6 -11.8114 methylpropanoate -11.8118 ▁rise -11.8119 =16 -11.8122 =3.9 -11.8122 -1,3( -11.8124 methylthiazole -11.8126 ▁held -11.8126 bromoacetate -11.8131 rel -11.8132 ti -11.8133 ▁29.6 -11.8136 [6- -11.8149 =50 -11.8149 ▁8% -11.815 ×200 -11.8151 -6′- -11.816 ▁102 -11.8168 [4- -11.8168 ,16 -11.8169 ▁18.8 -11.8171 ▁affords -11.8176 ▁(2.13 -11.8179 ▁22.4 -11.8179 phosphor -11.8182 methylbenzoyl -11.8183 ▁BOC -11.8185 ▁4-[(4- -11.8186 ▁Tetra -11.8187 ▁Onc -11.8189 propanediol -11.819 -­ -11.8191 ▁(3×25 -11.8195 ▁acetamide -11.8197 hydrazide -11.8198 dinitro -11.8198 ▁0.053 -11.8203 ▁95/5 -11.8205 -1-(2,4- -11.8207 ▁176 -11.8209 conditions -11.8213 ▁1-[3-( -11.8213 4.20 -11.8213 =36 -11.8215 ▁20.8 -11.8218 -(4-(4- -11.8219 ▁80%) -11.8222 ▁10.00 -11.8223 Condition -11.8223 IN -11.8226 ▁8.79 -11.823 ▁214 -11.8231 benzothiophen -11.8231 =10.0 -11.8235 ▁22.0 -11.8237 -(2 -11.8239 )-5-(( -11.8244 -6,11- -11.8253 ▁20.6 -11.8256 ▁4-((1 -11.8258 (3-(( -11.8259 ▁film -11.8261 ▁ethylenediamine -11.8262 hepta -11.8264 ▁22.7 -11.8267 ▁(265 -11.8269 ▁0.056 -11.8272 ▁bubbled -11.8277 ▁colored -11.8278 ▁set -11.8282 ▁Acetone -11.8284 ▁164 -11.8287 ▁(720 -11.829 {[(2- -11.829 ▁9.00 -11.8291 ▁contained -11.8293 stannane -11.8298 +0.1% -11.8301 ▁19.8 -11.8303 ▁(3×200 -11.8304 acet -11.8309 ▁0.085 -11.8309 ▁nitromethane -11.8309 ▁CO -11.831 oxime -11.8311 ▁6-(1- -11.8311 propanamido -11.8313 ▁(193 -11.8313 ▁6.17 -11.8314 ▁(0.043 -11.8316 no -11.8319 ▁5.81 -11.8321 ▁Cesium -11.8328 ▁22.8 -11.8331 ▁6.16 -11.8332 ▁Elution -11.8332 ▁3-(4-( -11.8332 ▁{( -11.834 ▁0.060 -11.8342 =9.4 -11.8349 )-3-(6- -11.835 quinuclidin -11.8357 =10:1) -11.8358 ′-(2- -11.8359 ▁(2.76 -11.8362 dodecyl -11.8363 70° -11.8366 ▁(2.07 -11.8366 ▁(315 -11.8367 ▁6.24 -11.8376 pentanoyl -11.8377 TMS -11.8378 ▁(194 -11.838 ▁(0.125 -11.838 ▁reached -11.8383 ▁propan -11.8386 ▁38% -11.8387 ▁178 -11.8387 ▁17.3 -11.8388 ▁acryloyl -11.8388 ▁Isopropyl -11.8395 ▁5.44 -11.8397 ▁neat -11.8399 ▁5.70 -11.8404 [4-(1- -11.8404 ▁(16.3 -11.8409 ▁2-[2- -11.8409 ▁(16.2 -11.841 ▁50:50 -11.8411 ▁plate -11.8411 ▁(660 -11.8413 ▁0.076 -11.8413 ▁(2.02 -11.8414 ▁(950 -11.8416 )-2,3,4,5 -11.8421 ▁5.60 -11.8423 ▁0.068 -11.8428 )-2-[ -11.843 ▁iodoethane -11.8433 ▁(0.048 -11.8435 0.1% -11.8436 ▁subject -11.8442 -[1,3,4] -11.8442 ▁5.95 -11.8443 ▁0.064 -11.8443 [3,5- -11.8446 ▁6.02 -11.845 ▁bottle -11.8452 ▁substantial -11.8452 isonicotinate -11.8455 4.28 -11.8455 ▁51% -11.846 ▁(216 -11.8465 =0.2 -11.8467 =27 -11.847 ▁(169 -11.847 ▁Extract -11.8471 decahydro -11.8472 ▁hydrolyzed -11.8472 ▁4-[4- -11.8472 ▁(218 -11.8472 carbomethoxy -11.8473 ▁0.078 -11.8479 =13.2 -11.848 ▁(285 -11.8486 ▁(2.80 -11.8487 ▁1:4 -11.8488 ru -11.8489 benzyloxymethyl -11.849 ▁21.0 -11.8493 ▁6.18 -11.8495 ▁(184 -11.8495 -4-[(4- -11.8497 ▁18.9 -11.8502 ▁utiliz -11.8502 ity -11.8502 ato -11.8503 ▁(16.4 -11.8504 nitrile -11.8504 ▁∼ -11.8507 ▁0.041 -11.851 ▁6.29 -11.851 ▁strength -11.8512 ▁5.84 -11.8512 ▁2-(3,5- -11.8512 [(2 -11.8513 ▁(1.81 -11.8514 ▁(2.24 -11.8514 po -11.8515 difluorobenzene -11.852 )-1-(6- -11.8524 =8.1, -11.8524 7.18 -11.8525 ▁um -11.8531 =11.2 -11.8531 ▁dropped -11.8532 ▁admixed -11.8532 hydroxybenzoic -11.8533 ▁26.0 -11.8534 ▁26.5 -11.8534 ▁5.78 -11.8538 3.20 -11.8539 ip -11.854 ▁5.80 -11.8557 ][1,5] -11.8561 oxindole -11.8562 ▁evaporate -11.8564 ▁(2.06 -11.8572 ▁object -11.8573 ▁215 -11.8575 binaphthyl -11.8575 ▁17.7 -11.8575 ▁(159 -11.8576 =47 -11.8579 OS -11.8581 ▁0.067 -11.8582 pro -11.8583 ▁−1 -11.8588 ▁trap -11.8589 ▁5.65 -11.859 ▁53% -11.8592 fluoroanilino -11.8597 ▁(191 -11.8601 ▁0.054 -11.8601 ,6,6- -11.8602 ce -11.8603 ▁4-(4-( -11.8605 ▁(0.085 -11.8605 ▁6.06 -11.8607 ear -11.8607 ▁(620 -11.8609 ▁0.072 -11.861 methylthiophene -11.861 -4-(4-( -11.8612 oxopyrrolidine -11.8612 chloroimidazo -11.8612 ▁osmium -11.8614 ▁4,4,5,5- -11.8614 3.10 -11.8616 ▁(0.038 -11.8618 (5-( -11.8619 ▁0.073 -11.8622 FA -11.8623 ▁While -11.8624 ▁(2.03 -11.8625 -7,7- -11.8626 Trifluoro -11.8627 tion -11.8629 ▁(2.85 -11.8631 -2,8- -11.8636 ii -11.8636 ▁0.039 -11.8637 -2-(3,4- -11.864 triphenylphosph -11.864 ▁micro -11.8641 ▁151 -11.8645 7.28 -11.8645 ▁Synthesis -11.8649 ▁17.9 -11.865 ▁substituted -11.865 ▁24.6 -11.865 ▁21.7 -11.8652 dioxoisoindolin -11.8652 25° -11.8652 ▁also -11.8655 ▁5.90 -11.8659 ▁29.7 -11.8661 [4-(4,4,5,5- -11.8663 -7.0 -11.8667 ▁diacetate -11.8671 oxaborol -11.8681 ((3 -11.8685 )-5,5- -11.8685 ]-2,4- -11.8688 ▁49% -11.869 phen -11.8691 7.41 -11.8691 ▁6.10 -11.8692 =3.7 -11.8696 ▁-40° -11.8701 ▁(570 -11.8709 ▁tartrate -11.871 ▁18.2 -11.8713 undecane -11.8714 -7.40 -11.8715 carbamimidoyl -11.8716 ▁5.87 -11.872 ut -11.8721 ▁(2.46 -11.8725 ▁22.6 -11.8725 ▁(276 -11.8726 ▁consistent -11.8727 ▁BH -11.8727 tricyclo -11.8729 ×1 -11.873 ▁(2.12 -11.8733 ▁De -11.8735 ▁6.31 -11.8735 -1,1'- -11.8738 )-9,9- -11.8738 ▁0.086 -11.874 ▁0.096 -11.874 ]-2′- -11.8742 ▁analytical -11.8743 =3.1 -11.8749 xylene -11.875 ▁ethane -11.8752 (4,6- -11.8752 ▁6.27 -11.8753 dicyano -11.8753 ▁Acid -11.8757 ▁(2.23 -11.8758 ▁(0.006 -11.876 ▁(1×) -11.8762 ▁rotamers -11.8768 ▁25.6 -11.8771 ▁26.4 -11.8773 -((5- -11.8777 ak -11.8781 dichloride -11.8782 layer -11.8783 1.17 -11.8786 late -11.8787 -(1-(4- -11.8788 ▁(17.2 -11.8791 ▁All -11.8796 cyclopropa -11.8797 synthetic -11.8799 ▁automated -11.8799 ▁operation -11.8799 ▁prop -11.8799 -70% -11.8805 ▁96%) -11.8809 ▁5.62 -11.8813 ▁(680 -11.8815 ▁(0.047 -11.8815 fluorobiphenyl -11.8815 thiophenol -11.8816 ▁21.6 -11.8816 ▁(2:1 -11.8817 ▁org -11.8819 ▁5.41 -11.8829 ▁still -11.883 -[5-( -11.8831 -4-[(1- -11.8833 ▁6.26 -11.8835 imidazolyl -11.884 ▁21.8 -11.8841 carboxymethyl -11.8849 ▁(0.029 -11.885 buten -11.8851 ▁(0% -11.8853 =48 -11.8853 oxazepin -11.8853 pyridylmethyl -11.8854 ▁oxali -11.8854 7.47 -11.8855 ,7,8- -11.8856 ▁low -11.8857 ▁0.061 -11.8857 ▁butyllithium -11.8857 -3-(6- -11.8858 1.05 -11.8864 purity -11.8867 trien -11.8869 ▁750 -11.8869 (1,3,2- -11.8872 ▁(2×5 -11.8873 ′,5′- -11.8874 ▁5.83 -11.8879 ▁(2.17 -11.8881 ▁(0.046 -11.8883 1,2,4,5- -11.8886 ▁(187 -11.8889 =41 -11.8897 ▁420 -11.8898 diisopropylamide -11.8899 [1-(2- -11.8903 -4-[ -11.8904 carbohydrazide -11.8904 ▁Dilute -11.8904 [2-[ -11.8907 (1,2,3,4- -11.8908 BA -11.8909 ▁Tr -11.8912 ▁evaporating -11.8914 ▁20.4 -11.8916 ▁5.48 -11.8916 ▁chromatographic -11.8918 4.00 -11.8918 ▁(254 -11.8922 4.25 -11.8925 ▁5.58 -11.8925 -3,7- -11.8926 oil -11.8926 API -11.8928 ▁8.88 -11.893 ▁29.4 -11.8932 propanal -11.8934 ▁freeze -11.8935 ▁(21.0 -11.8935 ▁(16.7 -11.8935 ▁58% -11.8937 ▁(640 -11.8938 ▁DEAD -11.8946 valine -11.8946 ▁silicagel -11.8948 ▁acetoacetate -11.8948 7.48 -11.895 =10.8 -11.8953 ▁154 -11.8954 ▁0.125 -11.8957 ▁61% -11.896 ▁□ -11.8965 ▁5.39 -11.8965 ▁(228 -11.8971 ▁un -11.8973 -1-[4-( -11.8974 -((6- -11.8976 ▁88%) -11.8976 ” -11.8978 ▁5.64 -11.8978 )-2′- -11.898 =17 -11.898 commercially -11.8983 ▁5.49 -11.899 ▁2,2'- -11.8993 ▁26% -11.8996 ▁Ni -11.8997 ▁bottomed -11.8999 ▁(0.008 -11.9002 ▁(22.0 -11.9002 Leu -11.9003 ▁6.21 -11.9009 ▁(2.70 -11.901 ▁(14.1 -11.9011 ▁[3- -11.9015 ▁Zinc -11.902 (4-((4- -11.902 ABq -11.9021 pentyloxy -11.9023 ▁0-5% -11.9024 ▁25.8 -11.9024 su -11.9026 ▁(224 -11.9026 ▁17.0 -11.903 ▁0.049 -11.9036 ▁meta -11.9041 ▁stopped -11.9041 -20% -11.9043 ▁(2.60 -11.9043 (10 -11.9045 ▁23.5 -11.9045 ▁(18.6 -11.9046 ▁(3×15 -11.9046 1.16 -11.9048 1,3- -11.905 ▁(2.34 -11.9051 ▁sticky -11.9052 2— -11.9054 ▁5:1 -11.9057 7.27 -11.9058 lithium -11.9061 oyl -11.9061 ▁(0.052 -11.9062 )-1,5- -11.9073 iodide -11.9073 7.16 -11.9074 ▁6.14 -11.9075 ▁18.3 -11.9078 ,8,8,11 -11.9084 ▁tetrabromide -11.9085 methylmorpholin -11.9086 ▁5.86 -11.9092 dioxino -11.9093 ▁6% -11.9094 ▁(0.058 -11.9095 Fluorophenyl -11.9103 ▁177 -11.9105 butenyl -11.9106 ▁ODS -11.9107 1.45 -11.9109 nicotinoyl -11.9115 ▁(181 -11.9122 -3-(1 -11.9123 500 -11.9127 ▁(80% -11.9128 -[7- -11.9131 ▁SPE -11.9133 ▁0.051 -11.9133 ▁5.98 -11.9136 ess -11.9141 )-8-( -11.9142 ]-8- -11.9144 benzoxazepin -11.9144 ▁(14.9 -11.9145 ▁5.56 -11.9147 ▁24% -11.9148 propynyl -11.9153 ase -11.9156 Diisopropylethyl -11.9157 ▁5-(( -11.9158 ▁0.200 -11.9159 ▁161 -11.9163 ▁-10 -11.9164 ▁based -11.9167 ▁Copper -11.917 ▁(15% -11.9171 ▁ex -11.9174 ▁triisopropyl -11.918 ▁along -11.9181 ▁minimum -11.9181 ▁310 -11.9181 )-5-(1- -11.9182 ▁tetrabutyl -11.9183 ▁(3.75 -11.9187 ▁(0.090 -11.9192 -2′,6′- -11.9196 od -11.9197 METHANOL -11.9202 chloroaniline -11.9204 ▁(0.400 -11.9204 dipiperidine -11.9205 ▁29.2 -11.9206 ethoxyphenyl -11.9206 -1-[3-( -11.9209 ▁28.9 -11.921 ▁(0.05% -11.921 ▁III -11.9217 ▁(0.056 -11.9225 dicarboxamide -11.9227 ▁CCl -11.9227 hydr -11.9228 1.19 -11.9231 {2-[ -11.9234 [3,2,1- -11.9235 ecrystallisation -11.9235 ▁19.9 -11.9235 ▁19%). -11.9237 ▁52% -11.9253 ▁grey -11.9257 ▁5,5- -11.9257 -5-[( -11.9265 ▁2-(3-( -11.9268 ure -11.927 ▁23.2 -11.927 ▁19.3 -11.9271 ▁29.5 -11.9271 ▁(15.1 -11.9275 ▁157 -11.9277 dodeca -11.9281 +1): -11.9282 ▁(207 -11.9286 ▁8.90 -11.9287 ▁(37% -11.9288 ▁turn -11.9289 ▁bright -11.9301 ▁biphenyl -11.9302 ▁(17.8 -11.9304 ▁6.23 -11.9307 ▁cautiously -11.9311 ▁(213 -11.9311 ▁4-(7- -11.9312 borane -11.9315 aqueous -11.9318 ▁(1.91 -11.9319 [5-(3- -11.9321 ▁leaving -11.9322 ▁Start -11.9322 ▁0.082 -11.9323 [1,1′- -11.9324 -1,1 -11.9325 ▁5.71 -11.9326 ▁32% -11.9332 ▁carbodiimide -11.9332 ▁way -11.9333 ▁5.91 -11.9339 hy -11.9342 methoxyquinolin -11.9343 ▁24.8 -11.9343 ▁(0.007 -11.9348 ▁92%) -11.9348 oxazino -11.935 ▁20.7 -11.9351 ▁only -11.9353 ▁hydrolysis -11.9355 glycinate -11.9355 ▁70%) -11.9356 (1,2- -11.9359 ▁Concentrate -11.936 4.10 -11.9361 azulen -11.9362 ▁result -11.9364 hydrophobic -11.9366 ▁5.79 -11.937 xanthene -11.9373 hydrazono -11.9376 ▁8.95 -11.9376 glycyl -11.9377 -(1-( -11.9384 triazaspiro -11.9388 +1)+; -11.9389 +1= -11.9395 -(1,1- -11.9396 ▁(189 -11.9396 ▁PyBOP -11.9399 ▁(20.5 -11.9399 ▁Soc -11.94 ]-1,4- -11.9402 ▁(0.095 -11.9403 ▁78° -11.9404 =11.6 -11.9404 =11.7 -11.9405 ▁276 -11.9406 ▁(0.053 -11.941 ▁0.0001 -11.9411 ▁0.095 -11.9411 0.98 -11.9412 [3-( -11.9412 pyr -11.9414 ▁propane -11.9414 im -11.9417 ▁0.088 -11.9422 ▁22.2 -11.9422 ay -11.9429 ▁296 -11.9429 {[5- -11.943 (3,6- -11.943 benzyloxyphenyl -11.9431 ▁18% -11.9431 ▁Filter -11.9431 [3.4] -11.9433 ▁5.51 -11.9433 ▁0.062 -11.9437 ▁(−) -11.9438 ISCO -11.944 ▁(2.38 -11.9442 ▁consist -11.9443 4′,4′,5,5,5′,5′- -11.9443 ▁purple -11.9443 ▁6.12 -11.9449 ▁Int -11.9451 ▁Bromine -11.9455 ▁thereafter -11.9455 ▁(2.44 -11.9458 ▁82%) -11.9458 7.09 -11.9462 ▁(217 -11.9465 =29 -11.9465 ▁14%) -11.9473 ▁97%) -11.9474 ▁60.0 -11.9476 ▁(0.031 -11.948 -5(6 -11.9483 4.11 -11.9486 iodopyridine -11.9486 ▁(3:1 -11.9488 ▁(+)- -11.9493 7.08 -11.9493 ethylphenyl -11.9495 phenylpropan -11.9496 [2.5] -11.9499 2.30 -11.95 ▁(208 -11.9503 ▁5.77 -11.9503 -17- -11.9505 ▁maintain -11.951 ▁1:9 -11.9512 ▁(21.5 -11.9513 ▁0.074 -11.9515 eluant -11.9518 7.23 -11.9521 ▁0.084 -11.9523 ▁(255 -11.9529 ▁Pa -11.953 ▁paper -11.9533 ▁-60° -11.9533 met -11.954 -4,9- -11.9541 rate -11.9541 ▁3-(1 -11.9544 7.43 -11.9545 ▁(18.3 -11.955 1.48 -11.955 7.05 -11.9551 ▁RBF -11.9556 ▁93%) -11.9557 yr -11.956 bromoethoxy -11.956 -[[ -11.956 ▁4:1) -11.9561 ▁(95%) -11.9562 ▁(0.057 -11.9564 ▁aliquot -11.9566 ▁0.079 -11.9566 1.30 -11.9568 ▁54% -11.9568 Dibromo -11.9576 -[1- -11.9582 ▁(80.0 -11.9585 ▁Al -11.9585 Chlorophenyl -11.9596 -{(1 -11.9596 aceto -11.9598 ACN -11.9598 phosphono -11.9599 ▁5.74 -11.9599 4.21 -11.9606 ▁83%) -11.9607 ▁(90%) -11.9608 benzisoxazol -11.9608 ▁prior -11.9611 ▁(0.009 -11.9615 ▁7:3 -11.9615 7.42 -11.9615 ′-(4- -11.9618 ▁56% -11.9619 ▁(2.36 -11.9619 ▁18.7 -11.962 acetoacetate -11.9622 ret -11.9622 ▁progress -11.9623 ▁{2- -11.9624 aminosulfur -11.9626 ▁1/1 -11.9627 cyclohexen -11.9634 ▁(9:1) -11.9636 ▁(3×5 -11.9636 ▁NaN -11.9641 ▁5.92 -11.9642 ▁0.105 -11.9644 ,12,13,13 -11.9645 ▁protocol -11.9645 ▁(2.09 -11.9646 (2,4,5- -11.9648 ▁0.083 -11.9649 ▁87%) -11.9649 ▁2-(2,4- -11.965 ▁13%). -11.9655 ▁24.5 -11.9656 ▁periodinane -11.9656 ][1, -11.9659 ver -11.9662 ▁28.2 -11.9666 ▁185 -11.9667 8.10 -11.9669 ▁put -11.967 iminoacetamido -11.9671 1.35 -11.9672 ▁obsd -11.9672 ▁(2.27 -11.9673 =9.9 -11.9676 ▁monitoring -11.9679 ▁5.63 -11.9681 bipyridine -11.9682 tetraaza -11.9689 ▁(0-10% -11.9691 =3.4 -11.9696 ▁Trifluoro -11.9696 ▁5.97 -11.9697 ▁Mg -11.9697 ▁8.92 -11.9703 ▁6.01 -11.9709 ▁1-(2,4- -11.9709 biphenylyl -11.9712 ▁identified -11.9713 ▁CELITE -11.9713 ((6- -11.9715 ▁5.99 -11.9715 ▁2-(2-( -11.9719 (4-(3- -11.972 OMe -11.9722 ▁(19.0 -11.9728 ▁active -11.9732 ▁turne -11.9737 )-7-(4- -11.9737 7.44 -11.9744 ▁(211 -11.9745 =7.9, -11.9745 -1-(2,6- -11.9745 ▁6.04 -11.975 azodicarbonyl -11.9751 ▁298 -11.9752 ▁91%) -11.9754 aminocyclohexyl -11.9758 isobutyronitrile -11.9763 =11.0 -11.9766 toluenesulphon -11.9775 ▁0.087 -11.9775 ▁6.09 -11.978 methoxyethanol -11.9785 ▁26.3 -11.9789 ▁24.2 -11.9795 Bromomethyl -11.9796 dibenzyl -11.9797 *,4 -11.9798 ▁PS -11.9798 ▁(19.2 -11.9805 ▁(99%) -11.9807 ▁0-30% -11.9808 methylbiphenyl -11.9808 ▁2-[4-( -11.9813 )-7-(2- -11.9814 7.19 -11.9815 [4.1.0] -11.9816 idene -11.9817 hydroxybenzyl -11.9821 ▁370 -11.9823 ▁22% -11.9829 ▁[2 -11.9835 ]-1,2,3,4- -11.9835 ▁(17.4 -11.9836 ▁5.53 -11.9836 ▁(2.01 -11.9836 ▁8.86 -11.9838 ▁5.67 -11.9838 ▁fumar -11.9839 ε -11.9839 ▁23% -11.9842 ▁micron -11.9843 0.25 -11.9846 oxoacetate -11.9849 oxido -11.9849 ▁(2.42 -11.985 eth -11.9851 ▁5.73 -11.9854 ▁(3.15 -11.9859 ▁205 -11.986 ± -11.9861 ▁0.070 -11.9864 ▁(70% -11.987 dichlorobenzoyl -11.9875 ▁31.8 -11.9876 ▁(2.19 -11.9879 ▁(179 -11.9883 7.00 -11.9886 ▁5.72 -11.9886 ▁benzhydryl -11.9894 ▁194 -11.9896 ▁(0.039 -11.9896 )-5-(5- -11.9901 )-6-(( -11.9909 ▁75%) -11.991 ▁eluents -11.9913 ▁42% -11.9914 cl -11.9915 oxopropanoate -11.9915 8.20 -11.9916 ▁5.94 -11.9917 Merck -11.9919 ▁24.7 -11.9921 ▁25.3 -11.9921 ▁29.3 -11.9923 indanone -11.9926 ▁84%) -11.9931 dimethylxanthene -11.9933 1.58 -11.9935 ▁(2×15 -11.9941 1.90 -11.9941 ▁exotherm -11.9943 ▁lower -11.9943 ▁dihydrogen -11.9945 ▁>99% -11.9946 ▁29% -11.9948 ▁0.00 -11.995 ▁(0.041 -11.9951 ▁(19.6 -11.9954 ▁increasing -11.9956 95° -11.996 ▁390 -11.9961 /20 -11.9962 ▁193 -11.9962 ▁(24.0 -11.9962 ▁5.47 -11.9963 ₆ -11.9967 ▁essential -11.9967 ▁8.87 -11.9971 ▁(0.072 -11.9971 50° -11.9974 ▁(244 -11.9974 ▁8.89 -11.9981 ▁flame -11.9991 dihydropyrazolo -11.9992 =11.4 -11.9992 ▁5.89 -11.9993 ▁5.82 -11.9998 ▁phosphite -12.0004 methoxyphenol -12.0007 2.25 -12.001 ▁linear -12.0014 phthalazine -12.0014 7.22 -12.0017 :1:1 -12.0018 ▁23.4 -12.0021 ▁(0.002 -12.0023 ▁0:100 -12.0023 ▁OBD -12.0026 hydrate -12.0029 sec -12.0029 8.25 -12.0031 ▁diazomethane -12.0035 ▁isopropylamine -12.004 ethano -12.0043 ,3′ -12.0045 ▁380 -12.0045 ▁Chloro -12.0046 -5-(( -12.0046 =12.8 -12.005 ▁(221 -12.0057 ▁(2.11 -12.0059 dibenzylamino -12.0065 ▁128.6 -12.0067 ▁1-[4- -12.0067 9:1 -12.0067 ▁3′- -12.007 ino -12.007 =9.8 -12.007 ▁iodo -12.007 ▁2:1) -12.0071 ochloridate -12.0072 ▁297 -12.0075 ▁128.4 -12.0078 ▁128.9 -12.0079 ▁163 -12.0084 4.30 -12.0089 ▁21.4 -12.0091 0:1 -12.0091 ▁(19.8 -12.0094 methylbutan -12.0095 ▁28.5 -12.0095 ▁Ex -12.0098 }-7 -12.0104 acid -12.0105 ▁24.4 -12.011 ▁23.8 -12.0113 acrylonitrile -12.0113 ▁19.1 -12.0114 ▁eluate -12.0114 -90% -12.0114 1.08 -12.0114 ▁27.5 -12.0116 ▁18.1 -12.0116 ▁1-(4-( -12.0117 ▁0.069 -12.0117 ▁(18.2 -12.0118 =12.1 -12.0119 =12.5 -12.012 ▁17%) -12.0122 ▁25.9 -12.0128 iodosuccinimide -12.0129 7.17 -12.0134 =3.8 -12.0136 ▁(234 -12.0136 tra -12.0137 ▁27.6 -12.0138 ▁nitro -12.0138 ▁(2.67 -12.0141 -2-(4-( -12.0145 ▁diastereomer -12.0146 ▁5.66 -12.015 =19 -12.0154 ▁azetidine -12.0157 -1,3′- -12.0159 fluoropyrimidin -12.0161 ▁(16.1 -12.0162 ▁(18.8 -12.0163 hydroxypyridine -12.0166 1.28 -12.0168 [6-( -12.0169 ▁10:1) -12.0173 Benzo -12.0177 ▁(3.25 -12.0179 ▁monoxide -12.018 dimethylpyridine -12.018 ▁CAS -12.0182 ▁1-(3,4- -12.0183 ▁Heptane -12.0184 8.15 -12.0186 ▁(2.33 -12.0186 trifluoroacetic -12.0188 ▁(0.078 -12.0191 ▁triflate -12.0192 ▁sol -12.0196 -3'- -12.0201 ▁6.08 -12.0204 ▁128.7 -12.0205 ▁(2.64 -12.0208 ▁size -12.0213 [(3,5- -12.0213 ▁26.7 -12.0223 bromoacetyl -12.0226 ▁128.8 -12.0226 ▁28.4 -12.0228 chloropyrazin -12.0233 ▁(2.56 -12.0234 ▁(%): -12.0237 ▁amounts -12.024 ▁0.0002 -12.024 0.88 -12.0247 [1-(3- -12.0248 ▁(2.32 -12.025 2.90 -12.0251 ▁235 -12.0252 dioxopyrrolidin -12.0253 ▁23.3 -12.0255 -2,6( -12.0258 ▁dimethylamino -12.0258 ▁6.07 -12.0258 propanone -12.0263 =10.4 -12.0263 by -12.0264 ▁0.097 -12.0267 )-2-(4-( -12.0268 cyclopenten -12.027 =8.59 -12.0274 ▁region -12.0276 1,2- -12.0278 tic -12.0282 (4-(2-( -12.0283 olate -12.0284 ▁25.7 -12.0285 concentrated -12.0287 ▁5.61 -12.0289 ▁furnished -12.0291 ▁6.13 -12.0292 ▁20.2 -12.0294 ▁34% -12.0296 ary -12.0298 ▁More -12.0298 isothiazole -12.0303 ▁179 -12.0303 ▁(0.066 -12.0303 3.30 -12.0304 1.95 -12.0304 ▁(0.054 -12.0306 ▁(19.4 -12.0306 diazepane -12.0306 ▁multiplet -12.0312 ▁sec -12.0313 ▁0.080 -12.0314 ▁22.1 -12.0317 4.19 -12.0318 2.70 -12.0321 ▁(8.00 -12.0321 ▁benzotriazol -12.0322 PP -12.0327 ▁(238 -12.0328 oxazolyl -12.0328 CAN -12.0328 rituration -12.0333 ▁Acetyl -12.0333 ▁60%) -12.0333 ▁cloudy -12.0336 ▁3-[2- -12.034 -4-(2,4- -12.0343 1.11 -12.0343 ▁1/2 -12.0344 7.29 -12.0344 )-1,1,1- -12.0345 ▁pentachloride -12.0349 7.21 -12.035 ,2,4- -12.0351 ▁malei -12.0356 ▁2-[3- -12.0357 ▁polymer -12.0361 ▁(227 -12.0366 ▁(35.0 -12.0366 80° -12.0367 -(2-(5- -12.0367 solution -12.0372 ▁5.57 -12.0378 (5,5- -12.0389 ▁12% -12.0396 ▁(0.084 -12.0396 ▁(0.003 -12.0396 ▁0.094 -12.0396 aminophenoxy -12.0397 ain -12.0397 ▁SP -12.0399 -[3-(3- -12.04 ▁5.93 -12.0401 4.39 -12.0402 1,2,3,4,4 -12.0407 ▁(2.48 -12.0411 ▁area -12.0413 ▁absorbed -12.0416 ▁1:2 -12.0418 ▁(2:1) -12.0419 ▁(0.120 -12.0419 ▁19.0 -12.0419 sulf -12.0421 -10,11- -12.0422 ▁5:95 -12.0422 ▁(2.66 -12.0422 ▁(0.063 -12.0423 ×250 -12.0424 7.20 -12.0431 ▁5.96 -12.0431 0.95 -12.0431 ▁294 -12.0433 [3.2.0] -12.0434 ▁(2.43 -12.0434 ▁(0.051 -12.0435 ▁59% -12.0438 3.25 -12.0439 5%). -12.0439 ▁Iso -12.0441 azobis -12.0442 ▁(222 -12.0442 dimethoxymethyl -12.0448 ▁AIBN -12.0449 pyridazinone -12.045 ▁8.96 -12.0453 -100 -12.0454 cinnami -12.0454 ▁128.5 -12.0455 ]-7 -12.0457 phenylenediamine -12.0459 ▁[2-(4- -12.0461 (400 -12.0462 leucine -12.0465 ▁5.54 -12.0466 ▁26.6 -12.0468 1.21 -12.0473 -3-[2- -12.0476 phenylmethoxy -12.0479 ▁(2×150 -12.0479 ▁(1200 -12.0485 ▁(2.21 -12.0485 methylacetamide -12.0488 =9.0, -12.0489 -[[4- -12.0489 ▁{4- -12.0491 ▁28.8 -12.0492 =11.5 -12.0493 ▁21.3 -12.0495 ▁(80%) -12.0495 ▁20.3 -12.0495 octadecahydro -12.0495 3.80 -12.0495 anhydrous -12.0496 1.55 -12.0498 ▁shows -12.0503 -(4 -12.0509 ▁191 -12.0511 +]; -12.0513 -13- -12.0515 nitrobenzamide -12.0516 ▁(780 -12.0518 ▁purify -12.0518 System -12.052 ▁(2.54 -12.0521 ▁4-[2- -12.0526 ▁(0.064 -12.0528 ▁8.93 -12.0529 ni -12.0533 ▁(610 -12.0535 -2-[2-( -12.0536 adamantane -12.054 lit -12.054 [3.5] -12.0545 ▁25.4 -12.0551 ▁singlet -12.0556 ▁physical -12.0557 -[5-(4- -12.056 ▁(2000 -12.0565 ▁0.500 -12.0566 methy -12.0567 ClFN -12.0572 ▁Sat -12.0575 ▁(9:1 -12.0576 -9,10- -12.0577 ▁245 -12.0579 ▁mix -12.0581 benzodioxole -12.0581 he -12.0582 ▁(35% -12.0585 ▁8.91 -12.0587 yldiimidazole -12.0587 itle -12.0592 =4.3 -12.0592 ▁0.059 -12.0598 ell -12.0598 pr -12.0601 -(8- -12.0602 ▁900 -12.0602 diacetoxy -12.0607 ▁(2.68 -12.0609 1,4,5,6- -12.0609 3.99 -12.061 ▁7% -12.0616 ynyloxy -12.0617 ▁Iodomethane -12.0619 ▁(0.067 -12.062 )-4-[( -12.0621 2.65 -12.0622 morpholinomethyl -12.0625 ▁26.8 -12.0626 clo -12.0626 ▁(2.22 -12.0627 ▁65%) -12.0629 ▁benzenesulfonyl -12.0631 ▁8.98 -12.0631 ▁201 -12.0632 phosphonoacetate -12.0637 ▁tricyclohexyl -12.0639 2.16 -12.0642 ▁(246 -12.0643 oxobutyl -12.0645 orange -12.0645 ▁(2.62 -12.0645 ▁(237 -12.0647 ▁(232 -12.0647 ▁6.03 -12.0648 ▁287 -12.065 ▁27.8 -12.0652 ▁(2.37 -12.0652 =10.5 -12.0652 ▁MW -12.0653 ▁(85%) -12.0653 )-(−)- -12.0656 ▁(590 -12.066 [3-(1- -12.066 ▁6.11 -12.0662 ▁265 -12.0666 0.90 -12.0669 ▁(2.78 -12.0669 ▁(670 -12.067 ▁(1.99 -12.0675 ▁188 -12.0677 ▁286 -12.0679 ▁characterized -12.0682 ▁46% -12.0684 ▁BF -12.0692 ▁(23.5 -12.0693 -(1,3- -12.0693 [2-(2,6- -12.0694 mobile -12.0695 -> -12.0697 ▁(10%, -12.0698 20.0 -12.0701 ▁(226 -12.0704 ▁(223 -12.0704 qu -12.0707 ▁dehydrated -12.0707 dihydropyrrolo -12.0713 ▁six -12.0714 -2-[4-(2- -12.0717 )-3-(4-( -12.0718 ▁SNAP -12.072 ge -12.0724 4.58 -12.0725 ▁5.69 -12.0726 ▁0.089 -12.0726 ▁98:2 -12.0729 ▁(206 -12.0733 [3-(5- -12.0734 ▁2-[5- -12.0735 ▁(2.47 -12.0736 ▁(18.4 -12.0737 ▁2,2,6,6- -12.0745 6.75 -12.0752 trimethylphenyl -12.0752 naphthalenyl -12.0755 isobutoxy -12.0757 isoquinolinyl -12.0762 3.15 -12.0763 ber -12.0767 4.40 -12.0768 ▁Boron -12.077 Pyridin -12.0771 ▁238 -12.0772 onohydrochloride -12.0774 ▁43% -12.0776 4: -12.0778 ▁Kg -12.078 ▁RM -12.0781 -4-[2- -12.0788 triethylammonium -12.0792 ▁(2.58 -12.0792 5: -12.0793 ole -12.0795 ▁NaCNBH -12.0795 benzamidine -12.0796 =13.6 -12.0798 ▁37.5 -12.0799 furanyl -12.08 uracil -12.0808 ▁Brine -12.0809 0.75 -12.081 1.29 -12.081 ▁45.0 -12.0812 )-2,3,3 -12.0812 ▁MsCl -12.0814 ▁192 -12.0816 azepino -12.0817 {[5-( -12.0819 chloropropane -12.0819 ▁dissolution -12.0821 -[3,5- -12.0826 ▁1-(( -12.0827 4.47 -12.0827 oxepin -12.0828 silanyloxymethyl -12.0831 ▁(2.88 -12.0831 ▁(4:1) -12.0832 ▁44% -12.0839 -8-(2- -12.0839 imide -12.084 ▁3-(3,5- -12.0845 ▁crop -12.0846 ▁thiocyanate -12.0846 ▁td -12.0851 ▁(0.004 -12.0853 {1-[( -12.0854 -[1-(3- -12.0857 ▁0.071 -12.086 benzoquinone -12.086 7.55 -12.0864 ynoic -12.0865 [5-(2- -12.0867 ▁79%) -12.0868 ×5 -12.087 ▁Isco -12.0874 ▁325 -12.0874 /50 -12.0876 =16.0 -12.0879 ▁Li -12.088 ▁248 -12.0881 -{5- -12.0884 tartaric -12.0885 diethoxymethyl -12.0891 Cyclopentyl -12.0891 ▁25.2 -12.0894 ▁Grignard -12.0898 ▁cannula -12.0898 ▁impurities -12.0898 ▁KF -12.0903 ▁6.19 -12.0904 bromophenoxy -12.0907 ▁(2.57 -12.0907 -((2 -12.091 ▁both -12.091 ▁impure -12.091 ▁1:3 -12.0913 ▁(95% -12.0913 ▁26.2 -12.0914 ▁264 -12.0915 )-4-(1- -12.0919 ⁻¹ -12.0923 8.00 -12.0929 ▁boiled -12.0936 crude -12.0938 ▁spiro -12.0945 ▁heterogeneous -12.0949 ▁quantity -12.0949 ▁8.94 -12.0951 4.09 -12.0953 ▁(3,5- -12.0953 [6-(2- -12.0954 ▁(3.05 -12.0959 ▁dimethylacetal -12.0963 mixture -12.0964 ▁275 -12.0969 ▁375 -12.0969 1.65 -12.0972 ▁[2-( -12.0974 ▁31.5 -12.0975 ▁(×2) -12.0982 -4′-( -12.0986 ish -12.0987 (5-(2- -12.0988 ▁0.081 -12.0988 ,8,11,1 -12.099 ▁(233 -12.0991 ▁(2.84 -12.0991 ▁(4.50 -12.0992 ▁(3.10 -12.0995 ×2 -12.0997 ▁(18.9 -12.0997 ▁(236 -12.0999 aminobenzoate -12.1 ▁30.5 -12.1005 ▁(2.29 -12.1007 ▁29.0 -12.1008 ▁(2.86 -12.1011 -1,4′- -12.1011 ▁190° -12.1012 ▁90/10 -12.1012 2.75 -12.1016 ▁{1- -12.1021 ▁440 -12.1022 -4-[4-( -12.1022 ▁187 -12.1022 1.68 -12.1023 benzodioxine -12.1024 ▁(15.9 -12.1026 ▁8.97 -12.103 ▁(90% -12.1031 -(9- -12.1032 ▁Analytical -12.1032 benzisoxazole -12.1033 -3,3 -12.1036 bromopropyl -12.1038 oxoazetidine -12.1039 ▁Excess -12.104 (1-(5- -12.1041 methylimidazole -12.1045 aRS -12.1048 ▁550 -12.1049 pteridin -12.1053 ▁33.3 -12.1054 methoxypropyl -12.1055 ▁336 -12.1055 ▁0.098 -12.1056 gen -12.1059 ▁23.0 -12.1061 ▁0.090 -12.1062 2.11 -12.1063 ▁128.3 -12.1064 ▁77%) -12.1065 ▁brownish -12.1067 -2-[(2- -12.107 ▁degrees -12.1074 ▁unreacted -12.1079 5,8- -12.1079 ▁cyclohexanone -12.108 1.14 -12.1083 alpha -12.1084 7.06 -12.1085 1/2 -12.1087 ▁CombiFlash -12.1089 ▁1-(3,5- -12.109 benzotrifluoride -12.1092 0.99 -12.1093 trifluoroethanol -12.1093 ▁21% -12.1096 ▁(19.3 -12.1098 ▁(0.062 -12.1101 AcO -12.1104 ⁺ -12.1105 ▁20.1 -12.1106 using -12.1107 ative -12.1112 val -12.1112 formamido -12.1115 ▁26.1 -12.1115 ylmethylene -12.1119 ▁ethynyl -12.1122 diazepan -12.113 keto -12.1134 ▁(5:1 -12.1136 ▁5.59 -12.1139 ▁2-[(4- -12.1141 ▁(2.95 -12.1143 -1-[(4- -12.1144 ▁very -12.1144 1.49 -12.1145 2.98 -12.1148 }-1,2,4- -12.1148 ×25 -12.1149 indolizin -12.1153 (1,2,4- -12.1154 ▁triacetoxy -12.1155 ▁later -12.1157 dibenz -12.1158 Phe -12.1158 man -12.1158 neat -12.116 (1,5- -12.1165 ▁460 -12.1167 -6-(( -12.1171 ▁(17.1 -12.1175 bromophenol -12.1177 4.68 -12.1178 ▁(4× -12.1182 -[(6- -12.1182 pentanone -12.1184 -7.45 -12.1185 Pro -12.1186 ▁1-[2- -12.1186 0.01 -12.1187 ▁(2.31 -12.119 ▁(17.7 -12.1194 ▁208 -12.1194 ▁[3-( -12.1195 ▁inorganic -12.1197 ▁Oxone -12.1197 ▁(0.105 -12.1198 cyclopropanamine -12.1201 ty -12.1202 ▁23.7 -12.1203 ator -12.1206 ▁(0.086 -12.1206 ▁76%) -12.1208 ▁9.08 -12.1208 ▁(0-50% -12.1211 ▁(3.20 -12.1211 ▁6-(5- -12.1213 ▁24.3 -12.1214 ▁11%) -12.1216 cyanopyridin -12.1216 -3-[2-( -12.1218 (4-(1- -12.122 ization -12.1223 ▁(23.0 -12.1223 ▁pattern -12.1224 ▁reported -12.1224 ▁raw -12.1224 1.59 -12.1225 ▁theoretical -12.1226 5.16 -12.1228 ▁(0.049 -12.1233 1.27 -12.1236 0.05 -12.1237 ▁λ -12.1239 ▁(2.52 -12.124 :0.5 -12.1241 onitrile -12.1241 ▁430 -12.1243 trifluoropropan -12.1245 ▁0.091 -12.1245 3.97 -12.1246 -7′- -12.125 ▁(3.45 -12.1251 methoxypropoxy -12.1252 -3,4′- -12.1253 ▁sulfonamide -12.1258 ▁(33% -12.1262 -5(2 -12.1263 ized -12.1267 eo -12.1267 ▁335 -12.1268 ▁32.0 -12.1272 acetylthio -12.1272 (2'- -12.1273 xanthen -12.1273 ▁0.5% -12.1274 }( -12.1274 1.09 -12.1276 ,14- -12.1282 ▁(2.72 -12.1282 ▁231 -12.1285 0.10 -12.1286 ▁27.4 -12.1286 0.20 -12.1291 ▁iPr -12.1293 3.40 -12.1301 methylisoxazole -12.1304 ▁28.3 -12.1305 -3-(2,2,2- -12.1307 sep -12.1311 =31 -12.1312 ▁(0.061 -12.1312 ▁2-[4- -12.1313 Cyclohexyl -12.1314 ▁(2.63 -12.1316 ▁(70.0 -12.1318 ▁(0.068 -12.132 ▁(345 -12.1322 ue -12.1323 4.41 -12.1324 iod -12.1324 =2:1) -12.1327 ▁5′- -12.1331 ▁(0.073 -12.1333 Chloromethyl -12.1337 (6-(2- -12.1341 ▁pyrimidine -12.1342 ▁0.092 -12.1343 ▁39% -12.1346 1.07 -12.1346 2.95 -12.1349 dichloropyridine -12.1349 butyn -12.135 dichloropyridin -12.135 ′-(3- -12.135 ▁2,4,5- -12.1354 =12.4 -12.1355 -1-[2-( -12.1357 ▁polyphosphoric -12.1357 ▁sparged -12.1357 ▁NaOAc -12.1361 ▁(231 -12.1364 ]-1-( -12.1364 2.80 -12.1366 ▁22.9 -12.137 ▁−75° -12.1371 -6(7 -12.1372 8.30 -12.1374 oxabicyclo -12.1375 chlorophenol -12.1375 hydroxypiperidin -12.1377 )-5-(4,4,5,5- -12.1378 ▁tetramethyl -12.1381 dithio -12.1382 chloroquinolin -12.1382 ▁stage -12.1384 ▁153 -12.1388 =10.2 -12.1391 ▁(760 -12.1393 ▁20.9 -12.1395 ▁Se -12.14 ▁doublet -12.1401 ▁28.0 -12.1401 {3-[ -12.1402 2.17 -12.1403 ▁80:20 -12.1405 ▁29.8 -12.1406 ▁positive -12.1407 ▁(7.00 -12.1408 Tetramethyl -12.1409 perhydro -12.1419 trichloroethyl -12.1419 -80° -12.142 ▁{3- -12.1422 )-2-(2,4- -12.1423 ▁0.093 -12.1423 ▁analyzed -12.1424 ▁trihydrate -12.1426 ▁255 -12.1429 ▁(247 -12.1431 ▁(2.77 -12.1432 1.26 -12.1434 ▁(19.7 -12.1436 ▁deionized -12.1438 60° -12.1443 methoxyquinoline -12.1449 ▁[4-(4- -12.1449 minute -12.145 be -12.145 ▁4-[(2- -12.1452 ▁23.6 -12.1454 ▁95:5) -12.1461 borate -12.1463 ▁(98%) -12.1463 4.31 -12.1464 -6-(2,3- -12.1464 carboxamidine -12.1465 -1,1,1- -12.1469 =7.5, -12.1469 diphenylsilyloxy -12.147 2.35 -12.147 amyl -12.1471 ▁7-(3- -12.1474 ▁(20.6 -12.1474 -8-(4- -12.1474 ▁222 -12.1478 ▁Fmoc -12.1479 ▁470 -12.148 ▁189 -12.1488 ▁Trimethyl -12.1491 serine -12.1492 Column -12.1496 ▁5-(6- -12.1497 )(4- -12.15 ((1-( -12.1503 ▁30.9 -12.1506 ▁410 -12.1514 over -12.1515 ▁228 -12.1517 ▁7-[2-(2- -12.1517 =14 -12.1518 ▁(3.16 -12.1519 (5-(4- -12.1519 ▁biphasic -12.1519 78° -12.1521 ▁233 -12.1525 ▁gray -12.1527 ethylenedioxy -12.1529 72° -12.1533 dihydroisoxazol -12.1537 ▁8.99 -12.154 ▁216 -12.1541 hexahydropyrrolo -12.1542 ▁Hex -12.1545 ▁(0.087 -12.1552 =4.1 -12.1558 ▁9.02 -12.1559 4.49 -12.1561 4.98 -12.1563 ▁(0.076 -12.1567 7.65 -12.1568 ▁9.09 -12.1569 ▁(20.2 -12.1574 [(2,6- -12.1581 opropylmagnesium -12.1581 alaninate -12.1588 ▁Symmetry -12.1588 ▁Phosphorus -12.1588 ▁(0.110 -12.1589 ▁4-[2-( -12.1589 =12.9 -12.1597 :10 -12.1601 ▁chlorite -12.1602 =8.34 -12.1602 3.05 -12.1603 =22 -12.1604 ▁(295 -12.1604 )-10- -12.1604 ▁9.05 -12.1606 ▁(16.9 -12.1606 nitroso -12.1607 ▁(0.077 -12.1609 ▁(690 -12.1613 ▁(3.30 -12.1613 ▁tetroxide -12.1615 ▁(2.90 -12.1616 heptanoic -12.1616 ▁4-(2,4- -12.162 {7- -12.162 ]-1,2,4- -12.1621 ▁21.1 -12.1624 ▁preparatory -12.1629 ax -12.1629 ▁tosylate -12.163 picoline -12.1631 ▁30.6 -12.1631 ▁(70%) -12.1639 tetrahydrofuro -12.1642 ▁comprising -12.1643 ▁213 -12.1645 1.56 -12.1645 ▁(0.074 -12.1645 6.80 -12.1648 pyrimidinone -12.1648 alanyl -12.1649 ▁(730 -12.1652 -2-[(4- -12.1656 hereinafter -12.1657 7.56 -12.1665 ▁206 -12.1667 ▁28.6 -12.1669 pentanol -12.167 ▁Synthesize -12.1671 ▁MDAP -12.1671 ▁(48% -12.1675 -1-[4-(4- -12.1677 =15.6 -12.1677 -1-((2-( -12.1681 ▁(880 -12.1687 =1:2 -12.1688 2.08 -12.1688 ▁(10%) -12.1693 iodomethyl -12.1695 ▁(25.5 -12.1697 ▁211 -12.1703 oxyimino -12.1704 =11.1 -12.1709 amidino -12.1712 which -12.1717 ▁(17.3 -12.1718 -3-[(4- -12.1721 1.24 -12.1723 )-2-((( -12.1723 [4,3,2- -12.1726 -2-(2,2,2- -12.1735 ▁(242 -12.174 ov -12.174 8.17 -12.1742 ▁345 -12.1742 ▁218 -12.1745 ▁3-(3-( -12.175 0.85 -12.175 The -12.1751 7.5% -12.1754 ▁(100-200 -12.1755 6.95 -12.1755 =12.3 -12.1756 propenoate -12.1758 ▁(2.74 -12.1758 4.15 -12.176 ′] -12.1761 ▁bi -12.1761 ▁chromatograph -12.1762 [6-(4- -12.1763 ▁30.1 -12.1763 beta -12.1763 4.97 -12.1763 ▁(0.001 -12.1765 6.90 -12.1769 ▁(0.088 -12.1773 dibromopyridine -12.1775 7.80 -12.1776 propylcarbamate -12.1777 ▁(201 -12.1779 3.18 -12.178 ▁13% -12.1782 )-5,7- -12.1785 ,4,4 -12.1785 ▁128.1 -12.1787 ▁ethanolamine -12.1789 ▁ethanolic -12.1799 ▁(21.6 -12.1802 ▁spec -12.1802 (3-(4-( -12.1802 thiazine -12.1805 MeOD -12.1806 {(3 -12.1807 ▁pivaloyl -12.181 ▁employing -12.181 ▁(22.4 -12.1811 ▁Thereto -12.1811 1.46 -12.1814 ▁th -12.1814 < -12.1816 7.11 -12.1819 ▁2-{ -12.1821 phosphorane -12.1826 ▁239 -12.1831 let -12.1831 AA -12.1832 ▁weekend -12.1838 -4,4′- -12.184 ▁(278 -12.1841 ▁mode -12.1846 ▁NCS -12.1849 ▁(268 -12.1851 3.75 -12.1852 ▁232 -12.1852 vi -12.1853 ▁7.30-7.2 -12.1855 7.75 -12.1855 ▁129.8 -12.1857 ]-1,2- -12.1859 -4-[3-( -12.186 thiadiazin -12.1862 ▁(2.83 -12.1863 ▁31.6 -12.1864 =11.9 -12.1867 ▁128.0 -12.1868 ▁31.7 -12.187 ▁cap -12.187 ▁0.150 -12.1873 imidamide -12.1875 ▁4-[2-(4- -12.1876 ▁32.4 -12.1877 enone -12.1879 ▁278 -12.1879 ▁whilst -12.1881 ow -12.1882 ▁236 -12.1882 AP -12.1886 =53 -12.1887 ((3-( -12.1889 {4-[2-( -12.1889 {6-[( -12.1891 methylpyrazole -12.1892 ,5′- -12.1893 -4,4,5,5- -12.1895 ▁other -12.1895 ▁2'- -12.1896 ▁fine -12.1896 ethoxyimino -12.1899 ▁3:1) -12.19 ▁(840 -12.1908 ▁Separate -12.1909 ▁Production -12.191 ▁(2×40 -12.1911 ▁(262 -12.1913 Ala -12.1915 =11.3 -12.1917 5,6,7,7 -12.1917 difluorobenzoyl -12.1917 ▁258 -12.1919 ▁9/1 -12.192 ▁34.5 -12.192 1.98 -12.1922 3.79 -12.1923 ▁Anhydrous -12.1923 ▁exceed -12.1923 5,5,8,8- -12.1924 -1,4 -12.1927 ▁4-[4-( -12.1927 6.65 -12.1928 ▁234 -12.1929 ▁9.25 -12.193 1.06 -12.1931 ▁Hunig -12.1934 ▁(3.12 -12.1936 ▁2-((( -12.1936 ▁(248 -12.194 4.67 -12.1941 Ethoxy -12.1944 ▁288 -12.1945 ▁(21.8 -12.1947 ▁(3.14 -12.1948 {[(1,1- -12.1949 ▁(20.4 -12.1951 ▁(3.40 -12.1957 aminophenol -12.1959 -0.5 -12.1962 ▁proton -12.1963 ▁268 -12.1965 4.35 -12.1966 ▁diisobutyl -12.1967 )-4,4,4- -12.197 ▁224 -12.197 1.39 -12.1972 ▁19% -12.1978 [7-( -12.1979 ]-2,6- -12.198 ▁338 -12.198 methyldisilazane -12.198 ▁226 -12.1982 ▁(96%) -12.1986 3.70 -12.1987 ▁24.9 -12.1988 carbethoxy -12.1989 7.07 -12.199 5.17 -12.1991 ▁perform -12.1992 ▁74%) -12.1996 (4-(4,4,5,5- -12.1997 ▁(3.60 -12.1997 ▁29.1 -12.1999 ▁(2.94 -12.2 ▁221 -12.2004 butyramide -12.2006 ▁9.15 -12.2006 ▁5-(4,4,5,5- -12.2006 ▁32.8 -12.2017 valyl -12.2017 ▁(28% -12.2021 ▁0.135 -12.2023 :5,4- -12.2023 Hydroxymethyl -12.2028 ]-2-(4- -12.2029 7.95 -12.2031 ▁equal -12.2034 ▁Gilson -12.2034 Al -12.2034 Iso -12.2036 ▁(2,4- -12.2038 ▁ten -12.2038 ▁septum -12.2038 ▁3,3,3- -12.2038 ▁35.7 -12.2039 ▁(3.18 -12.2041 described -12.2044 ▁3-[4-( -12.2045 ▁23.1 -12.2049 ▁(740 -12.2049 ▁27.2 -12.2049 ron -12.2051 -6-(6- -12.2053 ▁(2.82 -12.2053 [3-[ -12.2054 (5-(4-( -12.2055 -(4′- -12.2059 ▁(243 -12.206 tetralone -12.2067 cyclopentylamino -12.2068 7.13 -12.2071 ▁(256 -12.2073 ▁make -12.2077 ethoxyvinyl -12.2079 trichloromethyl -12.208 =7.6, -12.208 ▁gummy -12.2081 ▁(93%) -12.2083 ▁129.1 -12.2085 1.37 -12.2085 ▁(20.7 -12.2095 imed -12.2095 ][1,7] -12.2095 ▁100-200 -12.2096 ▁exact -12.2096 borohydride -12.2097 ▁(2.41 -12.2097 8.16 -12.21 # -12.2102 ▁21.9 -12.2102 ▁223 -12.2103 ▁(204 -12.2104 Aminomethyl -12.2105 ,6,7- -12.2106 -[[2- -12.2107 ▁reduce -12.2108 formate -12.2109 low -12.2118 ▁256 -12.212 ▁clean -12.2124 4.45 -12.2124 ▁imine -12.2124 -3-[4-( -12.2125 ▁Fro -12.213 ▁227 -12.2131 [2-(2,4- -12.2131 =2.4, -12.2133 ▁approx -12.2133 ylidenemethyl -12.2133 ▁23.9 -12.2136 4.78 -12.2137 ▁isoamyl -12.2139 3.90 -12.2145 ▁271 -12.2147 ▁(88%) -12.215 isohexane -12.2158 oxobutanoic -12.2159 0.06 -12.2166 tritylamino -12.2169 ▁soln -12.217 ▁(264 -12.2175 ▁324 -12.2176 ▁(0.175 -12.2176 )-6-(1- -12.2179 -5'- -12.2179 ▁(1:9 -12.2181 carbothioamide -12.2183 -1-(6- -12.2183 -2(5 -12.2188 ynoate -12.2192 ▁increased -12.2194 ₁ -12.2197 ▁permanganate -12.2197 ▁treating -12.2198 difluorobenzo -12.2198 diazatricyclo -12.2199 3′ -12.2199 ▁hypochlorite -12.22 nother -12.2201 -[4-(5- -12.2203 ▁(266 -12.2206 ▁(24.5 -12.2206 ▁did -12.2207 ▁(267 -12.2207 ▁(3.24 -12.2207 ▁(17.9 -12.2209 =11.8 -12.221 aminoethoxy -12.221 ▁rinsing -12.2212 1.02 -12.2212 ▁262 -12.2213 ▁127.6 -12.2215 -3-(3,4- -12.2217 ▁(2.51 -12.2219 ▁1-[( -12.2219 ▁28.7 -12.2223 3_ -12.2225 ▁Volatile -12.2226 ▁Data -12.2226 oro -12.2227 ▁31.2 -12.223 -(5-( -12.223 ▁Bu -12.2231 methylquinazolin -12.2232 1.38 -12.2233 chromatography -12.2234 nium -12.224 ▁pivalate -12.2241 ▁28.1 -12.2241 ▁(820 -12.2241 ▁127.8 -12.2242 12° -12.2243 ▁tosyl -12.2243 ▁186 -12.2244 ▁127.9 -12.2251 Val -12.2251 0.96 -12.2251 ▁(0.081 -12.2251 oc -12.2252 1.57 -12.2254 ▁Crystallization -12.2256 ▁26.9 -12.2257 ▁CV -12.2262 ▁(3:1) -12.2262 chlorocarbonyl -12.2265 {4-[(4- -12.2269 fluor -12.2271 ▁reference -12.2279 methylpropoxy -12.2282 idin -12.2283 ▁73%) -12.2283 ▁succinic -12.2285 2.85 -12.2285 ,7,8,8 -12.2289 naphthol -12.2289 ▁(2.73 -12.2291 ▁129.2 -12.2292 ▁products -12.2293 ,8,8 -12.2295 -(4-(4-( -12.2295 [1-(5- -12.2298 ▁−7 -12.2299 =7.7, -12.2299 0.16 -12.23 ▁sulfuryl -12.2303 4.60 -12.2303 ▁32.2 -12.2305 amin -12.2308 ▁209 -12.2308 ▁4-{ -12.2312 triethylamine -12.2314 6.60 -12.2317 NEt -12.2319 ▁129.9 -12.2321 ▁(26.0 -12.2322 fer -12.2322 ▁0.099 -12.2323 (1-(4-( -12.2324 7.58 -12.2325 ▁247 -12.2325 ▁27.3 -12.2333 ▁[6- -12.2333 ▁145° -12.2335 ▁protected -12.2336 ▁9.04 -12.2337 oate -12.2339 TOF -12.2344 ▁Cyclo -12.2346 1,2,3,5- -12.2349 ▁27.0 -12.2351 hexanoyl -12.2354 ▁pyrazole -12.2355 ▁480 -12.2357 ▁aid -12.2363 ▁(2.53 -12.2363 ▁(272 -12.2365 ▁27.9 -12.2367 ▁2-((1 -12.237 ▁230-400 -12.2374 -2,3,4,4 -12.2375 propylthio -12.2376 ▁(0.097 -12.2387 ▁hexahydrate -12.239 ▁tribasic -12.239 anthracene -12.239 sulfate -12.2392 1.36 -12.2395 ▁imidazo -12.2397 4.26 -12.2402 ▁4-[3- -12.2402 -((3 -12.2406 ▁(27.6 -12.2408 ▁(3.65 -12.2409 -7.50 -12.2409 ▁346 -12.2414 ▁25.1 -12.2417 ▁128.2 -12.2417 4.27 -12.2418 ]-6-( -12.2421 –1 -12.2422 ▁284 -12.2422 1.89 -12.2422 ▁(26.5 -12.2423 [2-(6- -12.2425 referred -12.2434 BF -12.2436 ▁(45.0 -12.2437 ▁(2.96 -12.2442 ▁methylate -12.2442 ▁(2.59 -12.2443 ▁127.7 -12.2444 ▁(21.3 -12.2448 ▁lyophilization -12.2449 ▁large -12.2449 ▁7.40-7.3 -12.245 our -12.245 ▁(0.082 -12.2452 4.18 -12.2455 7.85 -12.2456 ▁Tris -12.2456 ▁(3×150 -12.246 2.48 -12.2463 10.0 -12.2464 →1 -12.2465 tolylphosphine -12.2467 7.51 -12.2468 ▁1-[2-( -12.247 ▁(0.093 -12.2474 ▁trichloro -12.2475 1,1,2,2- -12.2475 ▁(86%) -12.2477 ▁~ -12.2478 ▁0.300 -12.2481 150 -12.2482 ▁(219 -12.2482 4,5,6,7- -12.2483 3.09 -12.2485 6.20 -12.2489 ▁isopropoxide -12.2494 sulfonimide -12.2494 ▁bisulfate -12.2494 ▁neutralised -12.2494 4.77 -12.2494 -2-[2- -12.2496 boc -12.2496 -4-(3,4- -12.2498 ▁(0.115 -12.2502 ▁reduction -12.2509 ▁oxone -12.2509 ▁4,4,4- -12.251 phenylacetamido -12.251 ▁(2.87 -12.2511 cyclohepten -12.2511 ▁31.4 -12.2511 ▁dimethylamide -12.2512 5.19 -12.2514 ▁66%) -12.2521 ▁minor -12.2522 ▁HOAt -12.2524 ton -12.2527 chlorosulfonic -12.2532 ▁229 -12.2532 ▁4-(2-( -12.2533 2.28 -12.2533 octadeca -12.2539 ▁mesylate -12.254 ▁244 -12.254 ▁(249 -12.2543 ▁(2.39 -12.2544 4.96 -12.2545 7.90 -12.2546 ▁269 -12.2547 ▁9.03 -12.2549 ▁(365 -12.2549 dioic -12.255 ▁(18.7 -12.255 ▁41% -12.255 methyldisilazide -12.255 methylisoxazol -12.2551 rt -12.2554 ▁exchangeable -12.2554 ▁1,6- -12.2556 ▁(229 -12.2559 -[4-(1- -12.2559 ▁32.6 -12.2564 '-( -12.2566 2.78 -12.2569 ▁minimal -12.2569 -3-[4- -12.257 ▁Nickel -12.2575 ▁bp -12.2576 {[1-(4- -12.2579 ▁2-((2- -12.2579 [(2,2- -12.2579 -((4- -12.2582 ▁(0.071 -12.2584 [4.2.0] -12.2584 1.88 -12.2586 ▁neck -12.2587 ++1) -12.2587 ▁217 -12.2588 ▁(3.06 -12.2589 ▁(97%) -12.2589 phenylpiperidine -12.2591 ▁27.7 -12.2593 250 -12.2594 ▁guanidine -12.2596 aminopiperidin -12.2598 salicylic -12.26 ▁24.1 -12.26 ▁207 -12.2601 )-1-[ -12.2602 ▁Hunigs -12.2603 1.51 -12.2605 coumarin -12.2615 ▁273 -12.2621 oxoethoxy -12.2622 1.01 -12.2625 ▁(28.5 -12.2626 of -12.2628 4.87 -12.2629 3.81 -12.2631 hexyloxy -12.2634 ▁219 -12.2634 =9.7 -12.2644 chlorobenzo -12.2644 ▁FC -12.2644 ▁spot -12.2645 ▁0.115 -12.2647 ▁2,7- -12.2649 ▁(84%) -12.2654 ▁(209 -12.2658 bp -12.266 -2,2 -12.266 aminopiperidine -12.266 ▁33.0 -12.2662 =12.6 -12.2663 CDC -12.2663 ▁ortho -12.2664 ▁(288 -12.2665 ▁AB -12.2667 azepane -12.2667 ▁Carbon -12.2667 ▁(0.083 -12.267 4.08 -12.2673 lic -12.2673 phosphinic -12.2677 ▁3-[3- -12.2677 ▁326 -12.268 8.19 -12.2681 ▁(2.93 -12.2688 phenacyl -12.2691 ▁dilution -12.2692 ▁30.8 -12.2692 phenylacetyl -12.2693 ▁(0.069 -12.2694 0.80 -12.2695 ▁2-[2-( -12.2697 ({ -12.2704 [8- -12.2705 ▁(0.096 -12.2705 carbapen -12.2708 ▁(2.49 -12.2709 7,8,9,10- -12.2709 tetraen -12.2712 ▁9.10 -12.2713 ification -12.2714 ▁9.16 -12.2715 ▁(2.71 -12.2715 ▁212 -12.2716 WO -12.2716 ▁HNO -12.2716 Ac -12.2718 ▁Manufactur -12.2722 ▁oxygen -12.2722 ylmethanol -12.2723 3.45 -12.2725 (1,1,1- -12.2737 ▁detection -12.2738 ▁Purifi -12.2738 [2.4] -12.2738 methoxybenzo -12.2739 -3-[(1 -12.2739 =12.2 -12.274 ▁(239 -12.2741 pyrrolidino -12.2741 cyclopentanol -12.2741 0.15 -12.2741 ▁64%) -12.2745 styrene -12.2747 methoxybenzyloxy -12.2749 cyanopyridine -12.2752 ▁Mixture -12.2753 3.95 -12.2753 3.08 -12.2754 ▁(335 -12.2764 ▁334 -12.2766 ▁36.0 -12.2766 ▁(3.80 -12.277 -2,3 -12.2771 butoxyethoxy -12.2775 -4-(2,2,2- -12.2779 [(3,4- -12.278 oxoquinoline -12.2787 {1-[ -12.2794 heptanoate -12.2799 xanthine -12.28 ▁272 -12.28 ▁IPE -12.2803 ▁processed -12.2803 ▁(21.4 -12.2805 ▁(92%) -12.2806 [4-(2,4- -12.2806 ▁(294 -12.2806 ▁(860 -12.2808 2.58 -12.2809 vacuo -12.2809 )-5-[( -12.2812 :30 -12.2813 ▁31.9 -12.2814 1.47 -12.2815 -(2-(( -12.2815 methylpyrido -12.2816 PA -12.2817 (3-(3- -12.2818 ▁Trans -12.282 ▁318 -12.2824 Heptane -12.2825 colored -12.2825 -1'- -12.2827 ▁(257 -12.283 ▁(0.135 -12.283 ▁recrystallised -12.283 ix -12.2832 ▁129.0 -12.2833 1.99 -12.2833 ▁328 -12.2837 -5-(2,2- -12.2837 ▁(18.1 -12.2841 ight -12.2843 ▁9.12 -12.2843 -6-[(1 -12.2843 ▁1/1) -12.2845 ▁disappearance -12.2846 ▁(3.28 -12.2847 ▁34.8 -12.2851 ▁Preparative -12.2852 =13.3 -12.2853 (2-(3-( -12.2853 =20:1) -12.2855 ketone -12.2856 ▁(3.35 -12.2857 ▁j -12.2859 ▁represent -12.2862 8(7 -12.2863 ▁(263 -12.2863 ▁pet -12.2863 6.10 -12.2863 ▁1-(2,6- -12.2866 2.49 -12.2866 dioxole -12.287 ,2' -12.2872 ▁entitled -12.2877 ▁Q -12.2882 -3( -12.2884 6.70 -12.2884 1.31 -12.2885 ▁(425 -12.2885 ▁181 -12.2886 90% -12.2886 =0.1 -12.2887 cyanoethyl -12.2891 ▁St -12.2891 bromoimidazo -12.2892 ▁waxy -12.2893 ▁(˜1 -12.2894 ▁129.7 -12.2895 ▁(94%) -12.2896 ▁hydrogensulfate -12.2897 8.50 -12.2899 -14- -12.2901 ▁67%) -12.2902 ]-1-(4- -12.2903 phenylhydrazine -12.2903 8.11 -12.2905 ▁(258 -12.2906 8.05 -12.2908 ▁Luna -12.2909 ▁329 -12.2909 ept -12.2909 ▁Sulfur -12.291 chlorobenzoate -12.2912 androst -12.2915 ▁benzamide -12.2916 ▁183 -12.2921 [2-(1 -12.2921 [3.3] -12.2924 iodobenzoate -12.2925 chloropyrazine -12.2928 ▁1-[4-( -12.2929 ▁9.07 -12.2932 ethylacetate -12.2936 ▁enantiomer -12.2938 ▁Chemistry -12.294 ▁(312 -12.2941 ▁399 -12.2941 ′,4′- -12.2942 +1, -12.2944 1-(4- -12.2947 ▁0.102 -12.295 ▁35.0 -12.295 ▁376 -12.2954 ▁315 -12.2955 ▁pentoxide -12.2956 ▁(21.2 -12.2959 ▁3-[4- -12.2963 ▁(37.5 -12.2964 2.55 -12.2965 ▁0.165 -12.2967 -(4-(6- -12.2968 ▁(292 -12.2969 ',5'- -12.2972 ▁337 -12.2973 ▁repeatedly -12.2974 indolo -12.2976 ▁(3×40 -12.2979 )+]. -12.2979 propionaldehyde -12.2982 2.45 -12.2986 ℓ) -12.2991 benzohydrazide -12.2992 ▁344 -12.2992 ▁(296 -12.2993 8.18 -12.2994 ylethynyl -12.2995 carbo -12.3009 2.38 -12.3009 ▁237 -12.301 ▁(770 -12.3011 Formyl -12.3012 ▁(55% -12.3014 phenylcarbamate -12.3018 ,2′- -12.3024 ▁(0.092 -12.3025 chloroethoxy -12.3031 ,5,7- -12.3032 =10.3 -12.3034 )-(+)- -12.3034 mesityl -12.3035 76° -12.3037 aster -12.3038 dihydropyridazin -12.3042 ▁˜1 -12.3048 ▁365 -12.3051 ▁(22.6 -12.3052 1,4,6,7- -12.3053 ▁3-(3,4- -12.3055 ▁283 -12.3059 ▁components -12.3059 7.59 -12.306 oxiranyl -12.3063 3.19 -12.3066 glycidyl -12.3067 -2' -12.3069 isatin -12.3071 ▁32.3 -12.3072 cyclopropylethyl -12.3072 trifluoroborate -12.3073 ▁9.01 -12.3073 ▁2-[2-(4- -12.3073 ▁3-[(4- -12.3075 phenanthren -12.3078 pentanamide -12.308 ▁274 -12.3081 ▁5-10° -12.3081 ▁Iron -12.3083 =8.9, -12.3086 ark -12.3086 Carbonyldi -12.3091 twice -12.3094 -95% -12.3097 ect -12.3099 ▁(415 -12.31 7.98 -12.3102 ▁347 -12.3104 ▁monomethyl -12.3107 ▁55%) -12.311 4.70 -12.3114 7.01 -12.3116 -[4-[ -12.3119 ▁abs -12.3123 ▁4-(3,4- -12.3124 ▁cyclo -12.3127 {[1-( -12.313 6.00 -12.313 ▁12%) -12.313 ▁poly -12.313 ▁diastereoisomer -12.3131 ▁(0.094 -12.3131 ▁(4-( -12.3132 )-4-(5- -12.3133 ▁Methylene -12.3133 ▁0-40% -12.3134 ▁333 -12.3137 )-4-(3,4- -12.314 malononitrile -12.3142 succinate -12.3142 ▁IV -12.3142 difuran -12.3146 ▁281 -12.3148 dimethylphenoxy -12.3153 ▁foamy -12.3155 electrospray -12.3158 ▁8-(4- -12.3162 ▁deposited -12.3163 isochromeno -12.3164 -2,3′- -12.3164 est -12.3165 ▁(870 -12.3165 ▁furan -12.3168 ▁(4.05 -12.3169 allyloxycarbonyl -12.3172 -{4-[( -12.318 /30 -12.318 ▁(960 -12.3188 ▁(2.69 -12.3188 )-1-((2-( -12.3188 ▁342 -12.3188 ▁29.9 -12.3189 ▁0.145 -12.3193 4.16 -12.3193 -[1,1'- -12.3194 ▁Borane -12.3195 ▁(3.36 -12.3197 oxaspiro -12.3199 ▁327 -12.32 pyridyloxy -12.32 ▁elute -12.32 ▁DPPA -12.3211 600 -12.3211 ▁(19.1 -12.3214 ▁289 -12.3218 chromane -12.3226 7.57 -12.3227 dicarbonate -12.3229 bromoaniline -12.324 ▁collect -12.324 ▁9.06 -12.3249 -3-(2,6- -12.325 ▁(85% -12.3251 ▁Mo -12.3251 bromopropane -12.3251 aminoethanol -12.3252 ▁petrol -12.3252 ▁(0-20% -12.326 =10.9 -12.3263 ▁(273 -12.3265 ▁Solvents -12.3265 -8-(3- -12.3265 ▁rinse -12.327 15° -12.327 ▁(87%) -12.3273 =54 -12.3278 ▁(4.25 -12.328 ▁arom -12.328 {[4-(2- -12.3281 ▁9.30 -12.3282 ▁external -12.3284 ▁Combiflash -12.3286 ▁58%) -12.3287 =10:1 -12.3288 ▁282 -12.329 phenylisocyanate -12.3292 ▁(20.3 -12.3294 ▁(23.4 -12.3298 ▁ethylmagnesium -12.3299 aminobenzyl -12.3302 ▁(25.6 -12.3302 ▁(91%) -12.3303 ▁(286 -12.3303 ▁(3.48 -12.3306 ▁35.6 -12.3306 ▁9.21 -12.3307 2.07 -12.3307 ▁isocratic -12.3309 ▁56%) -12.3309 isopropanol -12.3311 ]-5 -12.3312 ▁(2.97 -12.3313 ▁Th -12.3313 lan -12.3313 phenethylamine -12.3317 4.01 -12.3318 penten -12.3319 benzylcarbamoyl -12.3319 ▁267 -12.332 ▁4,4′- -12.3321 fluorobenzamide -12.3323 [[3-( -12.333 ▁(20.8 -12.333 ▁316 -12.3332 dioxine -12.3333 ▁184 -12.3334 ▁(2-( -12.3336 ▁Phenomenex -12.3337 ▁[1,1'- -12.3337 ▁348 -12.334 ▁(89%) -12.3343 7.68 -12.3346 ▁(27.5 -12.3352 ▁(2.98 -12.3353 Reference -12.3354 ▁IN -12.3354 -(5-(4- -12.3356 -4-[(3- -12.3358 lin -12.336 trione -12.336 6.88 -12.3361 ▁415 -12.3361 3.85 -12.3362 ▁129.5 -12.3364 2.27 -12.3365 ▁7.31-7.2 -12.3365 8.40 -12.3366 5.09 -12.3367 ▁(277 -12.337 ▁(284 -12.3371 "- -12.3371 ▁55.5 -12.3372 ▁(830 -12.3374 é -12.3374 ▁249 -12.3378 ▁(318 -12.3378 {2-[4-( -12.3383 methylpentan -12.3387 ▁10-90% -12.3387 Mass -12.3387 {5-[( -12.3388 -3,1- -12.3391 [5-(5- -12.3392 Methanesulfonyl -12.3393 )-6,8- -12.3394 ▁(75%) -12.3394 aminothiazole -12.3395 ▁0.104 -12.3397 4.17 -12.3405 ▁55.0 -12.3406 cysteine -12.3408 ▁61%) -12.3409 1.69 -12.341 6.98 -12.3411 ▁(0.079 -12.3412 0.17 -12.3412 5.10 -12.3415 )-3,4,5- -12.3415 ▁9.17 -12.3416 =13.1 -12.3418 ▁17% -12.342 ▁343 -12.342 ]-4 -12.342 ▁sulfonate -12.3421 1.96 -12.3423 7.88 -12.3423 chloropropoxy -12.3427 tar -12.343 methoxybenzamide -12.3431 ▁(1×50 -12.3432 ▁come -12.3433 ▁(75.0 -12.3435 ▁(21.7 -12.344 septet -12.344 ▁52%) -12.3441 100° -12.3448 difluoroacetate -12.3451 {4-[2-(4- -12.3454 ▁261 -12.3456 ▁-50° -12.3462 ▁Table -12.3463 hydroxyquinoline -12.3466 monitored -12.347 hyd -12.3474 ▁(22.3 -12.3475 ▁7.28-7.2 -12.3479 ▁(3.85 -12.3481 ▁7.32-7.2 -12.3482 ▁−6 -12.3483 UV -12.3488 ▁(83%) -12.3488 ▁diamine -12.3489 -2-(2-( -12.349 ▁34.2 -12.349 )-(1- -12.3492 ▁(7- -12.3494 ▁(+/−)- -12.3495 ▁1-(3-( -12.3499 ▁(25.4 -12.35 ▁diphenylmethyl -12.3501 estra -12.3507 ▁(2.61 -12.3507 ▁(3.13 -12.3508 ▁4-[5- -12.3508 ▁CuCN -12.3509 5.26 -12.351 )-1-(4-( -12.3512 ▁332 -12.3512 ▁9.11 -12.3515 cyclohexylamine -12.3519 ▁nM -12.3519 washed -12.352 ▁(2.79 -12.3521 ▁(316 -12.3522 ▁(0.130 -12.3522 ▁9.26 -12.3525 cyanobenzyl -12.3526 methylpropanoic -12.3526 azabenzotriazole -12.3527 ▁2-[4-(2- -12.3527 )-(-) -12.3527 3,6- -12.3529 ▁8:2 -12.353 1.67 -12.3531 ▁0.106 -12.3538 ▁pro -12.3538 ▁LiHMDS -12.354 ]-3-(4- -12.354 sulfonium -12.354 0.91 -12.3542 oxyethyl -12.3544 ▁(20.1 -12.3547 8.35 -12.3548 5.21 -12.3548 6.78 -12.3549 ▁(30.5 -12.3551 =11 -12.3552 ▁30.3 -12.3556 ▁−65° -12.3557 (11 -12.356 ▁0.136 -12.356 ▁pot -12.3562 ▁(261 -12.3562 ▁4-((4- -12.3562 {[(3- -12.3564 -3,4,5- -12.3569 ammonia -12.357 6.96 -12.3571 1.41 -12.3572 ▁Spec -12.3573 6.99 -12.3575 ▁(4.15 -12.3579 ▁(25.2 -12.358 ▁RediSep -12.3581 3.11 -12.3583 4,5] -12.3586 0.86 -12.3586 ▁chlorochromate -12.359 ▁3-(2,6- -12.3592 ▁378 -12.3593 ▁(305 -12.3594 ▁(326 -12.3595 ▁279 -12.3597 ▁filled -12.3598 [1,3- -12.3599 ▁dec -12.3604 ▁0.137 -12.3605 2.5% -12.3606 ▁6-(( -12.3606 =1/1 -12.3607 2.76 -12.3608 ▁(25.3 -12.3612 ▁129.4 -12.3613 3.35 -12.3614 ▁tr -12.3615 ▁(82%) -12.3615 TsOH -12.3621 3.01 -12.3621 ▁3-(7- -12.3625 ▁7.38-7.4 -12.3625 ▁339 -12.3628 ▁(2.89 -12.363 ▁ZnCl -12.3631 ▁331 -12.3632 ▁(27.0 -12.3636 -[5-(2- -12.3639 ▁0.128 -12.3645 ▁246 -12.3649 0.5% -12.3651 {[6- -12.3652 ▁2-(2,5- -12.3653 ▁(2.92 -12.3661 2,3,6,7- -12.3661 ▁129.6 -12.3662 cy -12.3666 ▁3'- -12.367 (2-(2-( -12.3672 ▁Finally -12.3675 methylthieno -12.3675 4.59 -12.3675 *,2 -12.3676 ,7,8,9 -12.3676 =5:1) -12.3677 ▁(1:2 -12.3683 ▁1,2,4- -12.3683 6.30 -12.3685 4.55 -12.3687 ▁243 -12.3687 sh -12.3688 -1-(3,4- -12.3689 ▁benzophenone -12.369 ▁(21.1 -12.3691 ▁diameter -12.3691 ▁LiBH -12.3691 ▁y -12.3691 ▁54%) -12.3693 -3-[3-( -12.3694 ▁(0.098 -12.3694 au -12.3697 4.07 -12.3699 -4-[2-(4- -12.3701 -{4-[4- -12.3707 3.16 -12.3708 ▁modifier -12.3708 ▁0.0003 -12.3709 ▁(3,4- -12.3711 ▁10:90 -12.3711 ▁341 -12.3712 [[(3 -12.3715 -1-{[2-( -12.3716 )-4-[ -12.3716 1.97 -12.3716 ▁34.6 -12.3717 ace -12.3718 ran -12.3721 ▁0.103 -12.3725 quintet -12.3726 6.67 -12.3726 ▁7.25-7.3 -12.3728 ▁Formic -12.3732 =14.0 -12.3732 ▁33.6 -12.3738 ▁39.6 -12.3739 chloroquinoline -12.374 ▁7.41-7.3 -12.3741 ▁349 -12.3742 ▁chlorocarbonate -12.3744 isopropenyl -12.3744 benzofuro -12.3746 ▁3° -12.3747 4.65 -12.3753 Tri -12.3753 =10.1 -12.3755 ethanolamine -12.3759 cyclobut -12.376 ▁30.7 -12.3761 oxopyridin -12.3764 ▁323 -12.377 ▁(2% -12.3771 trioxo -12.3773 ▁(274 -12.3773 ▁(328 -12.3778 thiadiazolidin -12.378 2_ -12.378 dimethylsilyl -12.3781 ▁16% -12.3783 ▁385 -12.3789 age -12.3789 preparation -12.3791 ▁sulfone -12.3792 quint -12.3792 -[8- -12.3795 ▁(3.17 -12.3796 ▁100/0 -12.3797 ′-(5- -12.3799 )+], -12.38 ▁129.3 -12.3801 ▁(2.81 -12.3801 oxopiperidin -12.3802 ▁1-(2,2- -12.3804 ▁(3.03 -12.3809 ▁reddish -12.3811 ▁(3.26 -12.3812 ▁test -12.3813 trichlorophenyl -12.3816 ,5,5- -12.3817 ▁32.5 -12.3823 ▁thiomethoxide -12.3828 -6-(3,5- -12.3829 ▁(22.2 -12.3831 decomp -12.3832 ▁allow -12.3836 5.28 -12.3838 pyrimid -12.384 -18, -12.3841 relative -12.3843 )(2- -12.3843 ▁7.42-7.3 -12.3844 8.09 -12.3846 ▁52.5 -12.3846 ,4,6- -12.3846 =13.5 -12.385 cyclohexanamine -12.385 oxepine -12.3851 -120° -12.3851 methylsulphonyl -12.3853 =3:1) -12.3853 -7.20 -12.3853 2.59 -12.3854 ▁characteristics -12.3854 42° -12.3856 7.99 -12.386 ▁bubbling -12.3862 ▁32.7 -12.3865 trichloromethane -12.3865 ▁36.5 -12.3866 aminosulfonyl -12.3866 ▁(28.0 -12.3867 ▁0.120 -12.3868 ▁regioisomer -12.388 ▁(314 -12.3882 oric -12.3884 VII -12.3884 ▁(3.32 -12.3884 ▁dimer -12.3885 -[1,8] -12.3887 ▁20:1 -12.3888 ▁(3.33 -12.3889 ▁(0.059 -12.3889 ▁263 -12.389 pyridone -12.389 -1-[(1 -12.3891 -4,5 -12.3892 ff -12.3893 -2,3,3 -12.3895 ▁pass -12.3896 cresol -12.3897 benzenesulphonyl -12.3899 ▁(269 -12.3899 ▁Trimethylsilyl -12.39 -4-((4- -12.3903 ,15- -12.3905 0.97 -12.3905 ,4,5- -12.3906 -1-[2- -12.3907 2.36 -12.3907 7.97 -12.3911 ▁311 -12.3911 chloroethane -12.3913 ▁literature -12.3914 phenylene -12.3921 0.89 -12.3924 -((4,6- -12.3927 Sep -12.3928 ▁291 -12.3929 ▁sequence -12.3932 ▁gms -12.3932 ▁490 -12.3933 benzylpiperidin -12.3935 ▁389 -12.3936 =21 -12.3939 ▁disodium -12.3939 ▁313 -12.3942 ▁(10:1 -12.3944 ▁(3.55 -12.3945 ▁stored -12.3949 ▁(31.5 -12.395 ▁(78%) -12.395 ▁266 -12.3953 ▁50/50 -12.3954 2.69 -12.3954 ▁31.3 -12.3956 -(6-(4- -12.396 triethylsilyl -12.3966 8.28 -12.3966 ▁sufficient -12.3966 ▁quickly -12.3966 ▁disappeared -12.3967 =100:0 -12.3969 benzylcarbamate -12.3969 ▁(81%) -12.3973 ▁2° -12.3974 -[6-( -12.3974 0.35 -12.3978 ▁[4-(2- -12.3981 50:50 -12.3981 0.18 -12.3983 ▁0.108 -12.3983 3.28 -12.3984 methoxypyrimidin -12.3985 nal -12.3988 6.97 -12.3991 ▁30.2 -12.3993 butyronitrile -12.3995 6.77 -12.3997 ▁0.126 -12.4 )-2,8- -12.4 ▁CuCl -12.4001 octa -12.4002 =10.6 -12.4007 Toluene -12.4008 ▁0.175 -12.401 =13.0 -12.401 4.79 -12.4013 4.75 -12.4013 ial -12.4013 8.75 -12.4018 ▁Formula -12.4019 sulfini -12.402 2.79 -12.402 ▁propionate -12.4021 enol -12.4022 ClNO -12.4022 =4:1) -12.4022 ▁quenching -12.4023 -1-(3-( -12.4025 ▁(4.45 -12.4026 ▁36.2 -12.4026 ▁(1:2) -12.4029 sept -12.4031 2.68 -12.4035 4.48 -12.4035 morpholinophenyl -12.4036 pregna -12.4037 ▁(3.34 -12.4037 ▁257 -12.4039 ▁7.38-7.3 -12.4041 ▁2-(4-(4- -12.4043 ▁3:2 -12.4043 oxospiro -12.4044 -(3-(3- -12.4044 ▁insolubles -12.4052 5/1) -12.4052 ▁35.4 -12.4057 (6-(3- -12.4059 1-(2- -12.406 -5% -12.4064 onic -12.4067 ▁Chiral -12.4069 ▁4-(3-( -12.4069 octyloxy -12.4071 ▁judge -12.4072 nonyl -12.4073 ▁(10:1) -12.4076 ▁Form -12.4076 ▁9.20 -12.4078 -8,8 -12.4079 ▁(20.9 -12.4079 -5-(1 -12.4079 ▁[1- -12.4079 5.80 -12.408 ▁(3.04 -12.408 ▁33.1 -12.4081 5.38 -12.4082 ▁(3.42 -12.4082 ▁(710 -12.4084 2.99 -12.4085 ▁0.2% -12.4086 ▁(355 -12.4087 -2.60 -12.4092 ▁31.0 -12.4093 ▁31.1 -12.4093 ▁(281 -12.4095 ▁(279 -12.4096 ▁(22.7 -12.4096 tosyloxy -12.4096 ▁0.133 -12.4098 6,8- -12.4098 [7-(2- -12.4102 ▁thiophenol -12.4103 Dimethylethyl -12.4103 ▁(0.106 -12.4106 TB -12.4106 ▁SFC -12.4107 oxetane -12.411 5:1) -12.411 -3-(2,4- -12.4112 trioxa -12.4116 ▁(336 -12.4121 8.06 -12.4121 isothiocyanate -12.4123 dithiol -12.4124 carbostyril -12.4125 ▁(100%). -12.4125 ▁1-(2-( -12.4125 ▁(298 -12.413 dimethylamine -12.4132 ▁(19.9 -12.4132 ▁(×3). -12.4135 ]-2,5- -12.414 2.29 -12.4143 aluminum -12.4143 4.99 -12.4143 ethene -12.4147 0.45 -12.4148 ▁(317 -12.4149 1.91 -12.4151 ▁34.7 -12.4153 ▁(74%) -12.4154 5.20 -12.4154 ▁56.0 -12.4156 ▁259 -12.4158 ▁(72%) -12.4159 -1(6 -12.4159 ▁emulsion -12.416 triflic -12.4161 )-2-(3-( -12.4161 tetrahydroborate -12.4165 ▁(22.8 -12.4165 ▁(3.43 -12.4167 ▁321 -12.4168 ▁(0.600 -12.4168 ▁Pat -12.417 1.61 -12.4175 ▁241 -12.4175 ▁blue -12.4178 ▁46.5 -12.4181 ▁Redi -12.4183 sulfur -12.4183 benzoxazepine -12.4186 thiomorpholine -12.4187 5.15 -12.4189 ▁(4.75 -12.4189 bor -12.419 OEt -12.4193 -(1-(3- -12.4193 ▁(5.50 -12.4197 -2-[4- -12.4201 iodopyridin -12.4205 ▁(293 -12.4207 -40 -12.421 -1-(3,5- -12.4211 ▁9.99 -12.4212 )-3-{ -12.4215 (1-(3- -12.4216 ▁(99% -12.4216 ▁“ -12.4217 ((2,2- -12.4217 sorb -12.4218 homo -12.422 ▁(3.70 -12.4223 ▁2-((3- -12.4225 pentafluoroethyl -12.4228 -2,2'- -12.4229 ▁9.14 -12.423 ▁cyanogen -12.4232 octahydrobenzo -12.4234 (5-(5- -12.4236 Methoxycarbonyl -12.4236 ▁(241 -12.4236 ▁EIMS -12.4243 ▁27.1 -12.4245 ▁(3.38 -12.4247 3.21 -12.4249 ▁32.1 -12.4249 ▁(0.113 -12.425 methanesulphonyl -12.4251 ▁30.4 -12.4251 heptyloxy -12.4252 ▁rhodium -12.4253 ▁(23.6 -12.4255 {4-[4-( -12.4256 2.31 -12.4258 4.38 -12.426 =10.7 -12.4263 sulfonylchloride -12.4265 ▁251 -12.4266 9.10 -12.4266 ano -12.4267 ▁(283 -12.4267 ▁2-[(2- -12.4272 bromoethanol -12.4273 3.07 -12.4278 ▁Tetrahedron -12.4279 =13.4 -12.4279 -(4,6- -12.4281 sulfo -12.4281 ▁exothermic -12.4282 2.67 -12.4283 carboethoxy -12.4283 ▁33.7 -12.4286 {4-[2- -12.4288 ▁355 -12.4289 ▁16%) -12.429 ▁0.400 -12.4292 ▁(4.30 -12.4294 ▁Sunfire -12.4295 ▁near -12.4296 3.06 -12.4297 -3-(4-( -12.4298 ▁(348 -12.4299 ▁(920 -12.43 ▁-20 -12.4302 ▁Morpholine -12.4303 ]-3,5- -12.4305 ▁277 -12.4306 ▁0.132 -12.4307 ▁(980 -12.4308 40.0 -12.4311 ▁(3.22 -12.4316 valeri -12.4318 [5-(1- -12.432 8.01 -12.4321 ▁deprotection -12.4322 oxazolylmethoxy -12.4322 8.08 -12.4323 0.2% -12.4323 ug -12.4323 ▁(2.91 -12.4327 [2-(3,4- -12.4329 dioxopiperidin -12.433 propyloxy -12.4332 ,5,7 -12.4332 ▁1,1′-( -12.4335 ▁7.33-7.2 -12.4335 RP -12.4338 ▁36.4 -12.4338 lysine -12.434 9.15 -12.434 (2-(4-( -12.4346 2.91 -12.435 6.05 -12.4354 ▁0.110 -12.4355 methylindole -12.4356 approximately -12.4357 ▁(289 -12.4358 ▁Detector -12.4358 =13.8 -12.4359 ▁(271 -12.4359 ▁0.114 -12.4361 ▁seconds -12.4364 ▁(77%) -12.4371 ▁0.109 -12.4373 trifluoropropyl -12.4374 Int -12.4374 ▁latter -12.4376 1′,2′ -12.4376 ▁(71%) -12.4378 ▁253 -12.438 ▁(3.54 -12.4382 ▁1-[2-(4- -12.4383 0.87 -12.4386 ▁435 -12.4386 ▁7.35-7.4 -12.4388 ▁11% -12.4393 Piperidin -12.4395 ric -12.4396 -3′ -12.4399 3.65 -12.44 0.50 -12.4401 ▁9.18 -12.4405 ▁One -12.4408 dimethoxyethyl -12.4409 ▁0.116 -12.4409 ▁127.5 -12.4411 -5-(2,3- -12.4412 ▁invention -12.4412 ▁KOtBu -12.4414 ▁(23.3 -12.4414 ▁2000 -12.4415 ▁(23.8 -12.4417 ▁0.185 -12.4417 1.87 -12.4417 ▁(24.4 -12.4424 8.26 -12.4425 ▁322 -12.4426 ▁425 -12.4428 =8.08 -12.4433 ▁(3.08 -12.4436 =13 -12.4436 ▁314 -12.4438 -(3-(2- -12.4438 ▁(3.90 -12.444 ▁(3.56 -12.4442 ▁42.0 -12.4444 ▁14% -12.4445 ▁(68%) -12.4445 orthoformate -12.4449 -2-[3- -12.4452 2.61 -12.4454 ▁369 -12.4454 ▁(0.091 -12.4454 Bromophenyl -12.4455 8.29 -12.4458 -2-(2,6- -12.446 0.60 -12.4464 ▁384 -12.4465 ▁(810 -12.4466 ▁formalin -12.4467 5.36 -12.4467 ▁develop -12.4468 1.54 -12.4469 salt -12.4469 hydrogen -12.447 4): -12.4472 formamidothiazol -12.4473 ▁cyanamide -12.4476 ido -12.4477 ▁377 -12.4478 ▁404 -12.4479 anil -12.4482 ▁caption -12.4485 ▁(0.103 -12.4486 ▁9.24 -12.4487 6.11 -12.4489 ▁41.6 -12.4491 ▁127.4 -12.4493 phosphinyl -12.4497 ▁(1×100 -12.45 Diamino -12.45 hydroxybenzoyl -12.45 bromothiophene -12.4501 ▁reactant -12.4504 imine -12.4505 ▁(24.6 -12.4508 rea -12.4513 cyanobiphenyl -12.4516 ▁38.5 -12.4516 res -12.4519 ▁(4.40 -12.4521 tyrosine -12.4522 Silica -12.4522 calc -12.4522 enamide -12.4524 ified -12.4524 )-3-[4-( -12.4525 -5-(2,2,2- -12.4525 8.45 -12.4526 2.47 -12.4526 ▁freed -12.4527 hydantoin -12.4533 )-1-[(2 -12.4533 /0.1 -12.4533 tan -12.4535 ▁317 -12.4535 ▁39.7 -12.4536 Propyl -12.4538 ▁Pt -12.454 =12.7 -12.454 BINAP -12.4541 conc -12.4541 ▁35.9 -12.4542 ▁396 -12.4546 yloxytris -12.4548 ▁1-[3- -12.4549 ▁4-((( -12.4549 bu -12.455 ▁40.5 -12.455 ▁0.118 -12.4551 -3-(2-( -12.4553 ▁0.158 -12.4554 methylbenzofuran -12.4555 ▁MgS -12.4558 ▁batches -12.4559 ▁relative -12.4562 [2-(3,5- -12.4566 1_ -12.4566 ▁70.0 -12.4567 3.48 -12.4571 ▁0.113 -12.4573 ▁38.7 -12.4573 ▁(1% -12.4575 ▁38.9 -12.4575 ▁gently -12.4578 ▁grade -12.4578 -3,9- -12.4578 ▁3-(2,4- -12.4581 ▁isolate -12.4581 ▁55.6 -12.4587 ▁2×50 -12.4587 ▁(287 -12.4588 VI -12.459 ▁0.146 -12.4591 ▁3-{ -12.4592 terephthal -12.4597 ,5,6,10 -12.4597 ▁(306 -12.4597 succinic -12.4597 -2-((2- -12.4598 ▁range -12.4599 ▁44.6 -12.46 16° -12.4601 -1-(4-( -12.4607 6-(2,2,2- -12.461 ▁suitabl -12.4615 ▁7.36-7.3 -12.4615 ▁(311 -12.4615 ▁(3.02 -12.4618 0.40 -12.4618 ▁46%) -12.4618 oxoimidazolidin -12.4624 dipropyl -12.4625 out -12.4625 EP -12.4625 -[5-(3- -12.4626 =7.83 -12.4626 (3-(5- -12.4628 ▁(3.11 -12.4629 ▁393 -12.463 (4-((( -12.4631 ▁59%) -12.4631 ▁(3.27 -12.4631 ((5-( -12.4632 basic -12.4632 ▁36.8 -12.4633 )-3,7- -12.4633 ▁rel -12.4635 ▁35.5 -12.4639 condition -12.4639 ▁312 -12.4641 ▁type -12.4643 80:20 -12.4644 ▁(0.180 -12.4644 ▁395 -12.4645 ▁iodobenzene -12.4646 enyloxy -12.4647 0.65 -12.4648 ▁EDAC -12.4652 ▁Hydroxylamine -12.4652 ▁contaminated -12.4652 total -12.4654 ▁(3.87 -12.4663 ▁acyl -12.4669 ▁(32.0 -12.4669 ▁Extraction -12.4671 ▁100.0 -12.4678 ▁(3.95 -12.4679 8.38 -12.4681 2.96 -12.4682 ▁4-[(3- -12.4682 dimethylbenzene -12.4682 ▁5:1) -12.4683 -110° -12.4686 3.26 -12.469 2.66 -12.4691 ▁7.25-7.2 -12.4692 ▁(2,3- -12.4693 dichlorophenoxy -12.4694 ▁9.23 -12.4694 ▁(33.0 -12.4696 cycloheptyl -12.4696 ▁manufacture -12.47 2.41 -12.4701 1.81 -12.4702 ▁0.129 -12.4703 ▁51.5 -12.4704 ▁3-[(2- -12.4707 ▁(790 -12.4707 ▁loading -12.4709 two -12.4709 ▁(24.8 -12.471 7.86 -12.4714 2.89 -12.4714 7.52 -12.4715 ▁(3.46 -12.4719 4(2 -12.472 ▁(297 -12.472 ▁2-[4-(4- -12.4721 6.40 -12.4724 dibromopropane -12.4724 Morpholin -12.4727 ▁screw -12.4727 {[(5- -12.4729 deca -12.4731 ▁−5 -12.4732 ▁(64%) -12.4733 ▁0.147 -12.4734 (1-(( -12.4736 ▁(3.37 -12.4737 ▁8-(2- -12.4739 ▁0.156 -12.474 ▁Steps -12.4741 base -12.4742 butyraldehyde -12.4746 ▁(0.089 -12.4747 8.07 -12.4748 ▁299 -12.4753 carbamoyloxy -12.4754 hexafluoropropan -12.4755 ▁propionyl -12.4759 ▁pyr -12.4759 ▁protection -12.476 ▁9.38 -12.4765 ▁phenylmethyl -12.477 ▁(24.3 -12.4772 ▁3-(2-( -12.4775 ▁EDCl -12.4778 ,9,9 -12.4779 ▁127.2 -12.4779 ▁acrylic -12.4779 ▁9.34 -12.4783 ▁fresh -12.4783 dithia -12.4785 0.68 -12.4786 ▁@ -12.4787 ▁(3.23 -12.4789 ▁millimole -12.479 pet -12.4796 ▁1:0 -12.4798 sulfon -12.48 ▁(73%) -12.4801 ▁35.2 -12.4802 ▁agitation -12.4803 ▁0.117 -12.4805 ▁(26.8 -12.4805 pentyn -12.4805 0.09 -12.4811 )-3-(3,5- -12.4812 ci -12.4814 2.97 -12.4814 ▁(3.07 -12.4815 ▁−11 -12.4816 )-3-(3,4- -12.4816 ▁(4.65 -12.4816 ▁34.3 -12.4816 ▁386 -12.4818 Biphenyl -12.4818 ▁provides -12.4819 ▁NaHMDS -12.4822 ▁(4.20 -12.4825 tro -12.4827 -(5-(( -12.483 2.56 -12.483 ▁(3.52 -12.4831 ▁55.8 -12.4831 dihydrofuro -12.4832 alic -12.4832 ▁363 -12.4834 ▁379 -12.4835 ]-1,1- -12.4835 ▁650 -12.484 6.86 -12.4841 ▁MeMgBr -12.4841 -2,4'- -12.4845 2.88 -12.4846 ▁475 -12.4847 ▁5,6,7,8- -12.485 ▁(76%) -12.4853 ▁PtO -12.4853 ▁achieved -12.4853 ▁9.13 -12.4853 ▁0.112 -12.4854 ▁80.0 -12.4854 ▁(+/−) -12.4858 ▁33.5 -12.4858 ▁proceed -12.4858 )-2-(2,6- -12.4859 like -12.4861 ▁cyanoacetate -12.4862 ▁(25.8 -12.4863 -5′ -12.4869 pivaloyl -12.4869 ▁7.43-7.3 -12.4873 ▁crystallize -12.4878 carbox -12.4878 ▁126.9 -12.4882 -4-(2-( -12.4889 -3,4 -12.4891 4.36 -12.4892 ethylbenzene -12.4892 ▁4-(3,5- -12.4894 ▁10-100% -12.4897 acetohydrazide -12.4899 ▁(3.64 -12.49 ▁130.0 -12.4903 ▁366 -12.4905 72.0 -12.4906 ▁44%) -12.4909 6.89 -12.4912 4-(3- -12.4915 0.07 -12.4915 ▁46.2 -12.4915 7.78 -12.4916 ▁356 -12.4916 isothiourea -12.4917 ▁9.22 -12.4919 (3-(2-( -12.4919 ▁367 -12.4923 ▁0.168 -12.4924 ▁371 -12.4925 sulfide -12.4926 ▁357 -12.4928 ▁381 -12.4929 ▁0.184 -12.493 phosph -12.4932 74° -12.4933 )-6 -12.4933 ▁properties -12.4936 -8,3′- -12.4936 Azido -12.4936 ,4′- -12.4938 -(4,5- -12.4942 ▁(65%) -12.4942 indolizine -12.4943 7.66 -12.4943 ▁39.5 -12.4945 ▁419 -12.4946 [(2,3- -12.4946 ▁0.107 -12.4946 ▁Bromo -12.4948 butynyl -12.4948 5.27 -12.4949 ▁(356 -12.4951 1= -12.4953 ▁identical -12.4955 dihydroxyphenyl -12.4958 ▁530 -12.4959 ▁(98% -12.496 ▁(26.3 -12.4961 ▁0.119 -12.4961 ▁(475 -12.4964 imi -12.4965 sulphonamide -12.4967 ▁(0.107 -12.4969 ▁chemical -12.4969 ▁(3.58 -12.497 6.08 -12.4971 sulphanyl -12.4975 mentioned -12.4976 ▁CsF -12.4977 3.96 -12.4978 ▁0.148 -12.4982 ▁7.37-7.3 -12.4982 -5-[(4- -12.4984 1-(( -12.4984 nitroquinoline -12.4985 [7] -12.4985 -4-[2-( -12.4985 8.27 -12.4992 cycle -12.4992 ▁spray -12.4994 8.48 -12.4994 -3,3'- -12.4995 [[(1 -12.4996 ▁(3.76 -12.5 ▁99:1 -12.5 Stage -12.5 ▁48%) -12.5002 7.96 -12.5003 bromopropoxy -12.5005 ▁520 -12.5006 6.87 -12.5007 dipyrido -12.5011 ]-2'(1 -12.5013 ▁employed -12.5013 ▁70:30 -12.5014 dioate -12.5019 ▁7-[2- -12.5019 ▁36.1 -12.5022 ▁34.0 -12.5022 ▁364 -12.5023 ,5,6,7 -12.5027 7.69 -12.5028 (2-(5- -12.5028 oxazolidinone -12.5031 ▁eV -12.5034 8.70 -12.5034 cinnamate -12.504 86° -12.5042 ▁7.35-7.2 -12.5043 cyanophenoxy -12.5043 ▁(525 -12.5045 ▁−10 -12.5046 7.04 -12.5046 ▁0.124 -12.5048 ▁(4.14 -12.5052 -4-[4- -12.5053 7.30 -12.5054 ▁Cooled -12.5055 ▁398 -12.5057 isobutyryl -12.5057 6.76 -12.5058 [1-(1- -12.5058 oxooxazolidin -12.5059 /25 -12.5062 ▁(36.0 -12.5069 xact -12.5071 ▁0.225 -12.5071 ▁pour -12.5072 }-2,3- -12.5073 ˜1 -12.5073 ▁wherein -12.5073 alk -12.5076 phenanthrene -12.5077 oxid -12.508 ▁(3.47 -12.508 ]-(4- -12.508 ▁0.152 -12.5082 -6-((4- -12.5088 ▁0.123 -12.5091 free -12.5093 ▁34.4 -12.5094 ▁(0.140 -12.51 ▁(0.112 -12.51 phosphane -12.5101 ▁32.9 -12.5102 amidine -12.5102 lute -12.5104 bromobenzoate -12.5106 -4-(3,5- -12.5108 48° -12.5113 {[6-( -12.5113 ▁(26.7 -12.5114 ▁42.5 -12.5116 ▁368 -12.5117 ▁0.195 -12.512 3.38 -12.5121 ▁4-[1- -12.5122 ▁(324 -12.5126 -9-(4- -12.5131 trihydrochloride -12.5135 -7.49 -12.5137 VIII -12.5139 0.08 -12.514 ▁56.1 -12.514 ▁polystyrene -12.5141 (4-((2- -12.5143 ',6'- -12.5144 Carboxy -12.5145 ▁Allyl -12.5146 96° -12.5146 ther -12.5148 ▁results -12.5148 azetidinone -12.5148 ▁decahydrate -12.515 {4-[(2- -12.515 ▁42.3 -12.5153 ceph -12.5155 -3,3,3- -12.5155 ▁(308 -12.5162 ▁127.1 -12.5167 9.20 -12.5168 (±) -12.5168 ▁cat -12.517 8.21 -12.5171 ▁36.7 -12.5171 DMA -12.5173 3,4- -12.5175 ▁56.5 -12.518 ▁(3.78 -12.518 ▁36.3 -12.5181 ▁azido -12.5181 ▁0.143 -12.5184 hexanol -12.5186 hexen -12.5187 5.96 -12.5188 -{( -12.519 acetimidate -12.5191 ▁33.2 -12.5192 ▁Methanesulfonic -12.5194 cyanoacetate -12.5194 ▁0.178 -12.5196 0.70 -12.5196 {2-[4- -12.5196 ▁55.3 -12.5197 Bromosuccinimide -12.5198 ▁(24.7 -12.5199 [2,6- -12.52 7.61 -12.5205 ▁319 -12.5208 ▁deprotected -12.5209 ▁XPhos -12.521 )-5-(6- -12.521 [3-(6- -12.5212 8(2 -12.5213 naphthoic -12.5214 ▁butanol -12.5214 ▁0.198 -12.5216 2.37 -12.5217 difluoroaniline -12.522 ▁(3.44 -12.5222 art -12.5223 ▁0.127 -12.5224 ▁mesyl -12.5229 film -12.5231 ▁(385 -12.5232 ▁spectral -12.5233 -(5-(3- -12.5234 -4-((( -12.5235 ▁55.4 -12.5239 4.06 -12.524 ▁39.3 -12.5242 triene -12.5243 ▁(366 -12.5245 cycloheptene -12.525 ▁IC -12.5257 8.60 -12.526 -(3-(( -12.5262 ▁careful -12.5268 phenanthroline -12.5268 Found -12.5271 -5-[(1 -12.5274 ▁(890 -12.5276 ▁(346 -12.5276 ,7′ -12.5277 ▁(5.25 -12.5281 (((3 -12.5281 ▁7.35-7.3 -12.5287 docosa -12.5288 ▁aged -12.5289 carboline -12.529 4.80 -12.5291 glycol -12.5291 morpholinoethyl -12.5292 ▁(327 -12.5293 3.68 -12.5294 eparatory -12.5295 ▁VI -12.53 ▁42%) -12.5301 ▁39.2 -12.5301 ▁9.28 -12.5302 ▁k -12.5304 ▁tlc -12.5308 ▁372 -12.5309 ]-2-(2- -12.5309 flash -12.531 amid -12.5313 ▁(0.160 -12.5316 7.67 -12.5317 ▁(259 -12.5317 qui -12.5319 4.85 -12.532 [4-[ -12.5321 XX -12.5323 3′,4′ -12.5323 ▁(2.99 -12.5326 formylamino -12.5327 ho -12.533 ▁64.5 -12.533 5.90 -12.5331 ▁(0.114 -12.5331 ▁(42.0 -12.5331 7.77 -12.5333 ▁roto -12.5335 ▁(372 -12.5337 ▁0.138 -12.5337 ▁(24.2 -12.534 ▁414 -12.5341 azaindole -12.5342 -7-((2-( -12.5342 {4-[3- -12.5347 thiepin -12.5348 ▁Elemental -12.5348 □ -12.5351 ▁1-(2,3- -12.5353 ▁(3.68 -12.5354 ▁418 -12.5356 -1-[4-(2- -12.5357 ▁351 -12.5358 ▁Da -12.536 ies -12.5364 ▁(435 -12.5365 8.31 -12.5367 -[6-(4- -12.5369 ▁case -12.537 ▁7.34-7.2 -12.5372 ▁(4.35 -12.5375 ▁(3.62 -12.5376 ▁0.134 -12.5377 -5-(4-( -12.5377 ▁(75% -12.5377 ▁9.60 -12.538 thiochroman -12.5381 ▁405 -12.5381 =1/1) -12.5382 ▁CuSO -12.5384 ▁Description -12.5385 ▁52.6 -12.5388 -[1,7] -12.5388 ▁Companion -12.5388 ▁Insoluble -12.5389 ▁165° -12.5391 EXAMPLE -12.5392 ▁45.4 -12.5392 ▁(4.80 -12.5392 ▁DL -12.5393 ▁(333 -12.5396 ▁4-[4-(4- -12.5397 ▁0.174 -12.54 sulphoni -12.5403 ▁(20.00 -12.5406 -[1,5] -12.5408 ▁45.6 -12.5408 phosphinate -12.5409 ▁394 -12.5412 ▁9.32 -12.5413 ▁torr -12.5418 ▁(3.67 -12.5418 ▁(251 -12.5418 ▁(95:5 -12.5419 ▁6-[ -12.5421 ▁(0.104 -12.5425 14.1 -12.5427 oxoazetidin -12.5427 ▁measured -12.5428 ▁−25° -12.5429 ▁BuLi -12.543 ▁411 -12.5432 =7.07 -12.5433 NaHCO -12.5435 ▁127.0 -12.5436 methylpyrazin -12.5439 ▁0.176 -12.5444 ▁(414 -12.5445 ▁0.155 -12.5446 uridine -12.5446 Fluka -12.5449 ▁usual -12.5449 ▁mmoL -12.5449 ▁washes -12.5449 ▁9.27 -12.5452 car -12.5457 (5,7- -12.5457 ▁dibenzyl -12.546 ack -12.5461 ▁overall -12.5461 ▁373 -12.5461 ▁38.4 -12.5467 ▁(31.8 -12.5468 entle -12.547 2.77 -12.5475 ▁(67%) -12.5478 1.77 -12.5478 )-1-(1 -12.5479 (1-(6- -12.548 ▁(495 -12.5486 ▁0.144 -12.5487 ▁original -12.5489 ▁42.2 -12.5489 ▁thereof -12.5489 ▁9.35 -12.5491 ▁(5.20 -12.5492 ethanethiol -12.5497 ,17- -12.5497 ▁0.188 -12.5497 ,2,7 -12.5501 bromobenzo -12.5502 ▁7.48-7.5 -12.5505 6.21 -12.5505 ▁initial -12.5509 ▁Magnesium -12.5509 -7-[( -12.551 cyclohexan -12.5515 ((3,5- -12.5521 tributylstannan -12.5522 ▁1-(1 -12.5522 3.27 -12.5523 ▁(0.165 -12.5524 ▁9.40 -12.5531 ▁0.172 -12.5538 oxocyclohexyl -12.5539 ▁1-[(4- -12.5541 {2-[2-(2- -12.5543 ▁{(1 -12.5546 ▁(25.7 -12.5546 ▁43.5 -12.5547 pheny -12.5553 brom -12.5553 methylpent -12.5556 ▁(28.8 -12.5558 ▁43.4 -12.5559 8.56 -12.556 6.06 -12.556 ▁437 -12.5561 ▁2-((3 -12.5564 ▁37.8 -12.5566 92.1 -12.5566 Glu -12.557 ▁cyanate -12.5571 isopentyl -12.5571 {4-[5- -12.5573 ▁pivali -12.5573 -2-[5- -12.5574 ▁(321 -12.5578 ▁41.3 -12.5578 ▁9.33 -12.5579 ▁383 -12.558 ▁rotamer -12.558 ▁(26.6 -12.5582 ▁˜2 -12.5585 4.56 -12.5586 ▁43.8 -12.5588 [1,3,2] -12.5588 ▁62.5 -12.559 ▁(940 -12.5591 ▁assay -12.5591 ▁0.0004 -12.5592 ▁41.4 -12.5592 ▁(0.145 -12.5593 ˜2 -12.5595 ▁(3.72 -12.5596 ▁(79%) -12.56 azine -12.5601 ▁(23.2 -12.5602 ▁353 -12.5603 ▁(23.7 -12.5605 ▁(0.102 -12.5607 ▁(3.88 -12.5608 -2,4,6 -12.5609 ▁spectroscopy -12.5612 77° -12.5613 ▁37.6 -12.5613 ▁{5- -12.5613 cyclobutanol -12.5614 ▁46.4 -12.5618 ▁(344 -12.5618 6.38 -12.5619 onium -12.562 ▁(4.12 -12.5623 -7.60 -12.5625 ▁(2×1 -12.5626 6.79 -12.5632 -[1,3,5] -12.5632 valerate -12.5632 ▁5-[( -12.5633 0.78 -12.5635 ▁slight -12.5638 ▁(7.50 -12.5639 ▁(3.09 -12.564 ile -12.564 ▁9.51 -12.5642 -3-[4-(2- -12.5644 pre -12.5647 chloromethane -12.5647 ▁herein -12.5652 ▁Observed -12.5653 8.37 -12.5653 ▁name -12.5655 ▁(32.5 -12.5656 ▁0.250 -12.5658 ▁cyclopentane -12.5658 ▁412 -12.5663 {5-[ -12.5665 ▁43%) -12.5667 ▁spectra -12.5669 ▁0.162 -12.567 ▁(34.0 -12.5671 ▁chrom -12.5678 ▁38.6 -12.5679 ▁48.7 -12.5681 ▁40.8 -12.5681 ▁0.163 -12.5682 ▁(1/1) -12.5683 ▁33.9 -12.5687 0.27 -12.5693 ▁stannous -12.5694 acetamidine -12.5697 ▁(354 -12.5698 ▁protons -12.5699 ▁49.5 -12.57 ▁9.75 -12.5701 ical -12.5701 FNO -12.5701 37° -12.5705 ▁(27.2 -12.571 1.71 -12.5716 ▁(0.108 -12.5721 [[4-( -12.5721 anilide -12.5721 ▁9.42 -12.5724 ▁component -12.5725 -4-{ -12.5726 ven -12.5728 ▁nitrile -12.5728 ▁445 -12.5732 ▁Lett -12.5736 ▁0-10° -12.5736 ▁446 -12.5741 ▁(∼ -12.5742 ction -12.5744 ▁48.0 -12.5744 ▁429 -12.5756 ▁(26.4 -12.5756 ore -12.5757 ▁(4.60 -12.5758 10.1 -12.5758 7.54 -12.5761 0.30 -12.5761 YMC -12.5762 dimethylimidazo -12.5763 ▁417 -12.5764 0.76 -12.5765 0.28 -12.5766 ▁(26.2 -12.5766 methylbutanoyl -12.5767 )-3,3,3- -12.5772 ▁45%) -12.5772 But -12.5776 ▁1,1,1,3,3,3- -12.5778 ▁(4.18 -12.5779 (2,2,6,6- -12.578 isobutyramide -12.5783 brine -12.5783 ia -12.5784 ▁DM -12.5788 =15.9 -12.5788 ▁(3.21 -12.5789 ▁391 -12.5792 tetrahydrospiro -12.5794 [3.1.1] -12.5798 (−) -12.5798 ▁Remove -12.5798 -25% -12.58 ▁(2×300 -12.5801 ▁plates -12.5803 /0.5 -12.5805 ▁476 -12.5806 azide -12.581 ▁peaks -12.5811 ▁(2×75 -12.5814 ▁similarly -12.5815 ▁41.5 -12.5815 -1,11- -12.5815 aceton -12.5816 ▁0.122 -12.5816 60.0 -12.5817 ▁(3×300 -12.5819 ▁fuming -12.5819 ▁[1-(4- -12.5821 9.09 -12.5822 ▁(27.8 -12.5823 ▁(0.126 -12.5824 nitrotoluene -12.5825 ▁tetraethyl -12.5825 -[[(2 -12.5826 ▁methyltriphenyl -12.584 ▁scheme -12.584 ▁(29.5 -12.5846 ▁(2×500 -12.5847 ▁control -12.5847 ▁(200.0 -12.585 ▁416 -12.585 ou -12.5851 ▁428 -12.5853 ▁9.19 -12.5853 ▁0.166 -12.5856 ▁7.45-7.3 -12.5859 ▁2,3,4,5- -12.586 ▁354 -12.586 ▁steel -12.5861 ▁xantphos -12.5861 ▁0.196 -12.5861 ▁(0-30% -12.5862 ▁34.9 -12.5863 ▁Sigma -12.5864 [1,1'- -12.5868 Methoxyphenyl -12.5869 -60° -12.5869 ▁(338 -12.587 ▁TiCl -12.587 0:100 -12.5871 ▁426 -12.5872 ▁Isolute -12.5873 we -12.5878 cyclopentene -12.5878 Arg -12.5878 6.48 -12.5879 [4-[2-( -12.5882 ▁3-((4- -12.5883 nate -12.5884 8.55 -12.5886 trop -12.5887 ▁40.6 -12.5888 catalytic -12.5888 hydroxypropoxy -12.5888 ▁0.186 -12.5892 8.68 -12.5893 7.76 -12.5895 -(2′- -12.5897 ▁(323 -12.59 12.0 -12.5902 ▁2-[3-( -12.5902 ▁(24.9 -12.5903 ▁cupr -12.5904 ▁Isolera -12.5904 ▁diglyme -12.5905 ▁cyclohexylamine -12.5906 ▁7.39-7.3 -12.5911 ▁35.3 -12.5911 ▁9.45 -12.5911 7(6 -12.5912 ▁Ti -12.5913 4_ -12.5917 ▁Cyclopropyl -12.5919 ▁penta -12.5919 ▁465 -12.592 ▁46.0 -12.592 ▁7.40-7.4 -12.5921 phosphoramide -12.5922 CA -12.5924 ▁Industries -12.5925 ▁supernatant -12.5925 -1,2,5,6- -12.5925 3.41 -12.5925 ▁(322 -12.5927 ethoxyphosphoryl -12.5927 azol -12.5929 ▁54.6 -12.5931 ▁7.22-7.2 -12.5932 -2-[3-( -12.5934 67° -12.5939 ▁7.27-7.2 -12.5941 5.68 -12.5942 ▁4/1 -12.5944 ▁55.9 -12.5944 ▁paraffin -12.5946 ▁submitt -12.5946 ▁lead -12.5946 ▁(332 -12.5949 ▁50-60° -12.595 Phenomenex -12.5952 ▁(3.96 -12.5954 ▁(3×75 -12.5955 ▁(0.155 -12.5959 ((6-( -12.5961 ▁tertiary -12.5961 ▁4-{2- -12.5961 each -12.5962 isoindolinone -12.5967 ▁deep -12.5967 ▁let -12.5969 ▁413 -12.597 ▁35.8 -12.5971 acetal -12.5972 ▁cobalt -12.5975 ▁34.1 -12.5976 ▁433 -12.5978 ▁2,8- -12.5979 methoxypropan -12.598 ▁(0.128 -12.5981 propylidene -12.5982 ▁41%) -12.5984 3.78 -12.5988 ▁Pre -12.5989 ▁intended -12.5989 ▁(0-5% -12.5989 (4-(3-( -12.599 ▁methylhydrazine -12.5992 cyclopropoxy -12.5993 6.26 -12.5996 =10/1) -12.6 ▁closed -12.6006 ▁benzofuran -12.6006 ▁55.7 -12.6008 ▁37.2 -12.6008 ▁(3.86 -12.601 apparent -12.601 ▁6′- -12.601 ▁(313 -12.6012 ▁(3.84 -12.6015 ▁(358 -12.6016 liter -12.6022 15.0 -12.6024 ▁397 -12.6024 ▁(63%) -12.6024 7.91 -12.6025 ▁GP -12.6025 fluorobenzo -12.6025 butyltin -12.6029 3.5% -12.6029 ▁Gemini -12.6031 iii -12.6036 ]-6,7- -12.6036 pentaen -12.6037 ▁7.30-7.4 -12.604 ▁0.325 -12.6043 ▁41.2 -12.6044 ▁bromobenzene -12.6044 ▁(0.185 -12.6047 ▁Pro -12.6047 ▁(4.10 -12.6047 ▁Patent -12.6053 ▁36.6 -12.6053 ▁(69%) -12.6054 ▁(66%) -12.6054 oranylidene -12.6055 BrNO -12.6058 ▁(65% -12.6058 ▁44.2 -12.606 ▁7.22-7.1 -12.6061 ▁acetylene -12.6063 ▁(395 -12.6067 ▁47.6 -12.6072 ▁(62%) -12.6075 84° -12.6077 ▁560 -12.6079 )-2-[(1 -12.6079 -3-((( -12.6083 ▁(100:0 -12.6086 6.91 -12.6087 ▁(28.6 -12.6087 6.09 -12.6094 ▁(3.66 -12.6097 cel -12.6103 ▁7.36-7.2 -12.6109 ethoxymethylene -12.6109 ▁(3.74 -12.6111 9.16 -12.6111 ▁(0.225 -12.6113 ▁130.2 -12.6115 ▁Precipitate -12.6118 ▁almost -12.6118 dimethoxypropane -12.6119 methylspiro -12.612 ▁7.21-7.1 -12.6126 ▁7.20-7.1 -12.6126 )-1-((( -12.6128 zole -12.6128 7.3% -12.613 81° -12.6137 ▁7.50-7.4 -12.6139 propiophenone -12.6139 ▁NIS -12.6141 ▁(9.00 -12.6141 ▁u -12.6142 fluoropiperidin -12.6143 5'- -12.6145 ▁35.1 -12.6145 3.49 -12.6147 7.89 -12.6147 ▁(343 -12.615 ▁7.24-7.2 -12.6153 )-2-{[ -12.6154 ({[ -12.6155 packed -12.6156 7.79 -12.6156 ethoxyethanol -12.6157 ▁(3.82 -12.6158 ▁478 -12.6161 ▁(424 -12.6163 ▁(4.08 -12.6166 benzylbromide -12.6166 {2-[4-(2- -12.6166 ½ -12.6168 fluoride -12.6169 ▁0.101 -12.6175 glyoxylate -12.6175 ▁374 -12.6176 line -12.6179 hexadecyl -12.618 2′,4′,6′- -12.6181 5.98 -12.6182 anisidine -12.6183 3.76 -12.6184 ▁(342 -12.6191 -2,4,5- -12.6194 ▁(25.1 -12.6195 58° -12.6198 ▁45.5 -12.6199 7.87 -12.6199 0.48 -12.6199 ▁5-(2,4- -12.62 ▁paste -12.6204 (300 -12.6205 octanoate -12.6205 ▁(4.55 -12.6205 ▁CuBr -12.6205 ▁0.130 -12.6206 )-4-(6- -12.6207 ▁(378 -12.6208 ▁line -12.6209 ▁9.29 -12.621 γ -12.6211 ▁(0.035% -12.6213 =13.7 -12.6218 ▁cyclic -12.6221 ▁vac -12.6224 ▁42.7 -12.6228 8.65 -12.6231 har -12.6232 ,6,7,8- -12.6232 ▁7.51-7.4 -12.6235 ▁33.8 -12.6235 -4-(3-( -12.6236 8.04 -12.6239 ▁6,6- -12.6239 ▁hemi -12.624 ▁(3-( -12.6244 BuOK -12.6248 ▁38.8 -12.6251 ▁HCOOH -12.6251 nicotin -12.6253 ▁nmr -12.6254 3.91 -12.6257 -4-{[( -12.6259 ▁(367 -12.6261 ocarbonate -12.6262 ▁7.26-7.2 -12.6262 methoxyethane -12.6262 ]-1,3,4- -12.6266 ▁358 -12.6268 9.5% -12.627 [4-(3,5- -12.6272 ▁particles -12.6272 ▁0.131 -12.6272 ▁0.164 -12.6273 ▁4-(8- -12.6276 Flash -12.6277 ▁0.235 -12.6277 diiodo -12.6278 ▁(3.63 -12.6279 ▁434 -12.6279 ×15 -12.6279 methanobenzo -12.6285 1-(2,2- -12.6288 ▁(970 -12.629 =8.84 -12.629 ▁2×100 -12.629 trade -12.6293 ▁diimidazole -12.6294 MgBr -12.6294 ▁0.160 -12.6299 ▁0.205 -12.6301 ▁41.7 -12.6302 ▁(55%) -12.6304 ▁37.4 -12.6304 ▁Triethyl -12.6305 diazepino -12.6306 ▁(31.0 -12.6308 Butoxy -12.6312 MeTHF -12.6313 ▁Residue -12.6314 ▁impurity -12.6314 ▁Pharm -12.6314 ]-1′(2′ -12.6314 ▁#1 -12.6315 ▁(29.4 -12.6315 -2′-( -12.6318 ▁9.65 -12.6323 )-3-[3- -12.6326 ×4) -12.6326 phenylalanyl -12.6329 ▁0.111 -12.6331 ▁given -12.6331 ▁7.52-7.4 -12.6332 hour -12.6333 120 -12.6334 7.71 -12.6338 ▁49.9 -12.6339 {[1- -12.6339 5.25 -12.634 ▁(22.1 -12.634 ▁TMEDA -12.6341 ▁" -12.6344 ▁127.3 -12.6344 ▁361 -12.6346 ▁0.154 -12.6346 -4-(7- -12.6351 ini -12.6352 =13.9 -12.6355 ▁37.3 -12.6357 hydroxyphenoxy -12.6359 ▁(0.350 -12.6361 )-1-(2-( -12.6362 Dihydroxy -12.6363 ▁439 -12.6365 ▁9% -12.6365 ▁4,7- -12.6365 cyclopentanone -12.6366 =4/1 -12.6368 ,4,7- -12.6372 ▁9.39 -12.6374 ▁Combi -12.6376 )-6,7,8,9 -12.6377 RT -12.6378 hydroxyl -12.6378 ▁(61%) -12.6379 ▁48.5 -12.6382 ▁4′-( -12.6385 ▁175° -12.6394 ▁rotovap -12.6395 0.55 -12.6399 4.88 -12.6401 ▁9.46 -12.6402 ((1-(2- -12.6402 adenosine -12.6403 ▁Ausbeute -12.6403 benzodiazol -12.6403 ▁0.206 -12.6408 ▁52.8 -12.6408 ▁7.58-7.6 -12.6409 cyclohexene -12.6413 ▁41.8 -12.6414 ▁(3.53 -12.6417 [1] -12.6422 '-(2- -12.6425 anthranilic -12.6425 ▁Schlenk -12.6425 ▁0.189 -12.6426 3.87 -12.6427 ▁(337 -12.6429 ▁7.44-7.3 -12.6429 pentanenitrile -12.643 ▁69.6 -12.6433 ▁37.0 -12.6433 ▁(21.9 -12.6435 =17.2 -12.6437 ▁(6.50 -12.6439 ▁42.4 -12.644 ▁37.1 -12.644 ▁(34.5 -12.6444 3.47 -12.6444 log -12.6448 ▁(4.85 -12.6448 0.58 -12.645 butylate -12.6451 ▁(0.220 -12.6456 ised -12.6458 )-3-(3-( -12.6468 ▁33.4 -12.647 ▁TBDMS -12.647 ▁3:7 -12.6471 ▁(38.0 -12.6471 ▁359 -12.6477 iodoimidazo -12.6477 benzooxazol -12.6477 ▁32%) -12.6479 -5,11- -12.648 ▁388 -12.6481 ▁510 -12.6482 ▁(5.10 -12.6483 isochromen -12.6484 ▁51.8 -12.6485 ▁37.7 -12.6487 ▁ruthenium -12.6488 ▁(0.099 -12.649 ▁LHMDS -12.6492 ▁thrice -12.6492 toluoyl -12.6492 ▁(0.138 -12.6492 ▁80/20 -12.6494 ▁0.215 -12.6498 -4-((3-( -12.65 /100 -12.6501 heptanes -12.6505 ▁cyanomethyl -12.6506 -5-[3- -12.6507 ▁7.23-7.2 -12.6508 ▁6-(6- -12.6508 4.90 -12.6508 ▁20:1) -12.6509 ▁−4 -12.6513 ▁(3.98 -12.6513 ▁dppf -12.6514 dioxaborinan -12.6515 -[[5- -12.6519 ▁66.6 -12.652 ▁(28.4 -12.6523 ▁438 -12.6524 0.79 -12.6525 ▁US -12.6525 cyan -12.6527 sulfinate -12.6528 ▁54.5 -12.6529 0.02 -12.6531 eno -12.6532 99.5 -12.6533 ▁540 -12.6535 -3-(3,5- -12.6535 ▁(2×250 -12.6537 propylcarbamoyl -12.6537 ▁7,8- -12.6538 ▁(3.29 -12.6541 ▁436 -12.6541 ▁53.6 -12.6543 ▁431 -12.6544 3.58 -12.6544 quinazolinone -12.6549 ▁0.153 -12.6549 3.46 -12.6549 5.77 -12.6553 ▁9.85 -12.6557 ▁39.0 -12.6558 ▁2-[(2 -12.6559 -(1-(2- -12.6566 ▁(36.5 -12.6569 ▁acetophenone -12.6569 ▁(331 -12.6569 ▁9.50 -12.657 methanesulfinyl -12.6571 ▁(4.95 -12.6574 )-2-(3,5- -12.6576 ]-6,8 -12.6577 ▁(31.4 -12.6577 4.95 -12.6577 ▁3-(5-( -12.6577 ▁(2,6- -12.6579 dimethylphenol -12.6581 ▁126.5 -12.6587 ▁[4-(3- -12.6587 ˜5 -12.6587 ▁(4.70 -12.6587 ▁441 -12.6588 ▁7.15-7.2 -12.6589 pressure -12.6591 ▁9.31 -12.6592 [(1,1- -12.6592 3.88 -12.6592 ,11,11 -12.6593 alcohol -12.6594 -(1,2,4- -12.6595 3.39 -12.6596 /40 -12.66 ▁1:2) -12.66 ▁4-[3-( -12.6602 3.89 -12.6603 ▁44.0 -12.6606 ▁(0.170 -12.6607 lactone -12.6612 ▁7.23-7.1 -12.6613 ▁130.1 -12.6614 75:25 -12.6614 ▁(31.6 -12.6617 -4-[3- -12.6617 ▁(3.01 -12.6619 ▁69.4 -12.6619 methylpiperazino -12.6619 {[4-(4- -12.662 ▁(0.116 -12.662 ▁1500 -12.6625 ▁nitrobenzene -12.6626 ▁421 -12.6627 [2,3,4- -12.6628 ▁Appropriate -12.6628 ▁Two -12.6628 ▁52.0 -12.6631 -9-(2- -12.6634 ▁anh -12.6636 ▁(0.109 -12.6636 0.69 -12.6637 8.5% -12.6637 ▁(3.93 -12.6638 5.39 -12.664 ▁around -12.6641 -140° -12.6641 Benzenesulfonyl -12.6643 ▁50.2 -12.6643 ▁40.3 -12.6646 =7.58 -12.6647 6.27 -12.6648 ▁(0.101 -12.6649 annulen -12.665 Eluent -12.665 ▁Piperidine -12.665 ▁mercaptan -12.6651 imidate -12.6651 thin -12.6651 ]-4-(4- -12.6652 ▁collecting -12.6653 ′,6′- -12.6653 =56 -12.6655 ▁43.6 -12.6656 ▁(3.57 -12.6658 UPLC -12.6659 nitrobiphenyl -12.6659 ▁(364 -12.666 ▁sulfami -12.6662 ▁fumarate -12.6662 ▁[2-(2- -12.6663 ▁(5.15 -12.6664 -4,4,4- -12.6667 (3-(3,5- -12.6667 dodecane -12.6669 -4( -12.667 ▁sulphoxide -12.6679 ▁NaIO -12.668 ▁(4.16 -12.6683 ▁−12 -12.6684 ▁main -12.6685 ▁(388 -12.6685 -5-[2-( -12.6688 8.77 -12.6688 ▁39.8 -12.6689 ▁56.4 -12.6693 8.7% -12.6695 Diethyl -12.6696 (3-(6- -12.6696 ▁separating -12.6696 1.5% -12.6696 ▁61.7 -12.6697 ▁(291 -12.6698 ▁(0.136 -12.6698 ▁9.80 -12.6699 dimethylpropane -12.6701 ▁(4.36 -12.6703 ▁0.159 -12.6704 benzylsulfanyl -12.6705 Lys -12.6706 8.76 -12.6707 ▁azetidin -12.6708 oxybenzoic -12.6708 ▁°-5 -12.671 3.36 -12.6711 ▁67.5 -12.6715 ome -12.6716 ▁4-[(1 -12.6717 ▁9,9- -12.6718 ▁Nitrogen -12.6719 ▁0.121 -12.6719 ▁9.36 -12.6723 TA -12.6723 bromothiazole -12.6724 ▁42.6 -12.6724 =15.8 -12.6725 ▁(3.41 -12.6725 difluorophenol -12.6729 11.2 -12.673 ▁(363 -12.673 ▁0.139 -12.673 ▁thiol -12.6731 ▁(347 -12.6734 ▁46.1 -12.6735 =16.4 -12.6736 ▁48.8 -12.6736 sila -12.6737 ▁43.1 -12.6739 ▁45.8 -12.674 74.0 -12.674 )-7-(( -12.6741 ▁Acetate -12.6742 ▁KMnO -12.6742 ▁dichlormethane -12.6742 ▁chloroacetate -12.6743 ▁chlorosulfonyl -12.675 balloon -12.6751 ▁387 -12.6753 ▁0.177 -12.6756 6.49 -12.6756 ▁7.23-7.3 -12.6757 =5/1 -12.6758 -(+)- -12.6758 ▁PREPARATION -12.6758 ▁(58%) -12.6759 ▁71.4 -12.6761 ▁7.45-7.5 -12.6762 ▁48.6 -12.6764 -5-(3,5- -12.677 ▁39.4 -12.6773 nitropyrimidine -12.6776 imidazolidinone -12.6776 ▁(56%) -12.6776 ▁hexahydro -12.6778 0.04 -12.678 ▁(31.2 -12.6783 ▁alpha -12.6784 ▁3-[3-( -12.6785 6.81 -12.6788 ▁briefly -12.6788 ▁(−78° -12.6788 ▁9.52 -12.6789 ▁neutralization -12.6789 ▁97:3 -12.6791 ▁(29.2 -12.6791 ▁bromomethyl -12.6796 nitroquinolin -12.6799 ▁(3.19 -12.6799 ▁[3-(4- -12.6802 91° -12.6802 enecarboxylate -12.6803 chloropyridazin -12.6806 thi -12.6806 ▁(930 -12.6807 ▁0.167 -12.6809 254 -12.681 ▁3-[5- -12.6812 ▁(377 -12.6812 isoquinolyl -12.6813 ▁(29.6 -12.6814 ▁45.7 -12.6814 ▁65.7 -12.6816 ▁36.9 -12.6817 8(1 -12.6817 ▁0.375 -12.6817 ▁(28.3 -12.6818 ▁(0.121 -12.682 ▁ketal -12.682 ▁58.1 -12.6823 ▁9.55 -12.6829 (2-(2-(2- -12.6832 ▁406 -12.6833 ▁(2,2- -12.6833 ▁2-(8- -12.6833 ▁could -12.6835 picolinaldehyde -12.6835 ang -12.6837 ]-1,7- -12.6841 ▁7.49-7.4 -12.6843 Pent -12.6844 Thi -12.6847 ▁TFAA -12.685 ▁(382 -12.6856 ▁Evaporate -12.6858 ▁turnings -12.6858 ▁thiosulphate -12.6858 ▁hydroiodide -12.6858 ▁semisolid -12.6858 ▁Ice -12.6859 7.94 -12.6866 ▁0.218 -12.6867 [4-[[ -12.6874 ▁7.46-7.4 -12.6877 ▁2-(1-( -12.6878 ▁tetrahydropyran -12.6878 -1,2,4 -12.6881 was -12.6881 ▁0-5 -12.6881 ▁enantiomers -12.6882 -6-[4-( -12.6884 ▁(384 -12.689 ▁51.6 -12.689 approx -12.6891 [4-[( -12.6892 ▁9.58 -12.6893 ▁51.7 -12.6894 carboxyl -12.6896 ▁1-((2 -12.6897 ▁(368 -12.6897 ▁packed -12.6897 tolu -12.6898 ▁41.0 -12.6899 -15% -12.6899 ▁53.5 -12.69 ▁xylenes -12.6905 ▁TsOH -12.6909 ▁(22.9 -12.691 -(3'- -12.6911 8.57 -12.6911 ▁126.8 -12.6913 ▁silyl -12.6914 ▁(3.73 -12.6915 ▁(4×50 -12.6917 ▁55.2 -12.6918 ▁−78 -12.6922 70.0 -12.6922 ▁0.180 -12.6924 -90° -12.6925 ▁absorption -12.6928 ▁dithionite -12.6928 ▁spectrometry -12.6928 dimethoxybenzene -12.693 ▁Benzoyl -12.6931 -130° -12.6935 3.37 -12.6939 ▁(77% -12.6939 thioureido -12.694 ▁(357 -12.694 ▁5'- -12.6943 ▁(30.7 -12.6943 ▁naphthalene -12.6945 ▁(4.24 -12.6946 0.77 -12.6949 ▁Ammonia -12.6951 valeryl -12.6951 vapor -12.6952 (2′ -12.6952 [7-(3- -12.6953 ▁acrylonitrile -12.6954 ▁44.4 -12.6957 =14.4 -12.6957 6.57 -12.6958 ][1,3,4] -12.696 8.39 -12.6964 ▁424 -12.6964 ▁43.3 -12.6965 oxocyclohexane -12.6966 ▁58.8 -12.6968 ▁130.5 -12.6969 (1-(2-( -12.6971 methan -12.6971 ▁(387 -12.6973 ▁DDQ -12.6975 {1-[4-( -12.6976 suspended -12.6985 ▁(53%) -12.6986 1,2,3,4 -12.6987 =17.6 -12.6988 methylbutanoate -12.6988 8.46 -12.6989 (2,3,4,6- -12.6992 ▁(57%) -12.6992 anhydride -12.6992 ▁427 -12.6994 -1-[5-( -12.6995 -1.75 -12.6997 ▁exp -12.6998 -2,4(3 -12.6998 adenine -12.6999 ▁0.245 -12.6999 ▁(23.9 -12.6999 rimethylaluminum -12.7001 ▁Base -12.7002 10,11- -12.7006 ▁EtOAC -12.701 ]-3-(2- -12.7015 ▁0.151 -12.7015 ▁61.5 -12.7015 ▁1,3,5- -12.7022 ▁fi -12.7026 ▁(3% -12.7029 ▁(5.30 -12.7035 Ethoxycarbonyl -12.7037 ▁(329 -12.7037 ▁155° -12.7037 ▁468 -12.7039 ▁(32.4 -12.7041 ▁new -12.7046 ▁sufficiently -12.7047 ▁cl -12.7048 ▁126.4 -12.7049 ▁0.204 -12.7049 ake -12.705 ▁2-((4- -12.7052 ▁(3.31 -12.7053 (2,3,4- -12.7053 ▁448 -12.7054 petrol -12.7057 ▁0.286 -12.7058 ▁0.315 -12.7058 ▁0.246 -12.706 ▁51.9 -12.7061 ▁HCL -12.7066 6.15 -12.7066 ▁ferrocene -12.7068 ▁Treat -12.7071 Chem -12.7072 quinolinone -12.7072 ▁56.2 -12.7073 )-1-{ -12.7073 ▁4-{3- -12.7075 ▁(456 -12.708 ▁(412 -12.7081 80.0 -12.7082 (4-((3- -12.7083 3.31 -12.7085 ▁(33.5 -12.7086 ▁42.1 -12.7086 ▁trityl -12.7086 OTf -12.7086 thiomorpholin -12.7087 ▁2-[(3 -12.7088 quinolizin -12.7089 0.57 -12.7092 ▁like -12.7092 ▁56.6 -12.7094 ▁(339 -12.7098 nor -12.7106 ▁7.45-7.4 -12.7107 }-2-( -12.7107 ▁57.8 -12.7108 ▁Ru -12.7109 ▁(4.46 -12.7111 ▁(334 -12.7112 ▁(29.0 -12.7113 ▁133.3 -12.7114 11.1 -12.7116 (1,2,3,6- -12.7117 ▁9.67 -12.7118 -4-[[ -12.7121 irected -12.7122 ▁(4.32 -12.7125 9.07 -12.7129 dihydroxypropyl -12.7132 ▁53.4 -12.7134 nonadec -12.7135 ▁43.2 -12.7136 ▁White -12.7141 ▁detector -12.7141 ▁forms -12.7143 phthal -12.7144 {4-[(1 -12.7146 filled -12.7153 methanaminium -12.7153 ▁250° -12.7153 ▁(0.129 -12.7154 -2-(3-( -12.7157 ▁45.2 -12.7159 ▁le -12.7164 ▁(90.0 -12.7165 ▁0-15% -12.7167 =17.4 -12.7169 methylpropanoyl -12.7173 ▁(21% -12.7174 5.97 -12.7175 propyn -12.7183 ▁42.9 -12.7184 ▁(95:5) -12.7184 ▁unit -12.719 ▁(4.04 -12.7194 =9:1) -12.7196 ▁delta -12.7197 BB -12.7198 ▁39.9 -12.7198 ▁commercial -12.7199 ▁7.20-7.3 -12.72 ▁(29.7 -12.7203 butyne -12.7205 ▁>95% -12.7206 6.25 -12.7207 ▁Ra -12.7207 ▁9.48 -12.721 volume -12.7213 ▁(4.06 -12.7216 ▁0.207 -12.7218 ▁469 -12.7218 ▁phthalic -12.7221 ▁4-((5- -12.7222 itol -12.7222 ▁7.25-7.1 -12.7223 ▁(4.34 -12.7224 Dioxo -12.7226 ▁19:1 -12.7227 Fluor -12.7233 dihydropyrimido -12.7234 ▁azeotropic -12.7237 ▁crystallisation -12.7237 ▁least -12.7237 dimethylbiphenyl -12.7238 carbamyl -12.7238 ▁50.8 -12.7238 ▁(59%) -12.7238 ▁magnetically -12.7238 phospho -12.7245 ▁phenylmagnesium -12.7246 HATU -12.7249 ▁38.0 -12.725 ▁56.3 -12.7251 ▁5-10% -12.7251 ▁0.173 -12.7252 ▁(0.275 -12.7257 ▁occurred -12.7262 ▁479 -12.7264 ▁69.3 -12.7264 ▁42.8 -12.7264 picolyl -12.7265 )-3-[(2 -12.7266 gluco -12.7267 2,3,3 -12.7269 ▁9.43 -12.727 -7,9- -12.7271 ▁7.60-7.5 -12.7271 ,8,10 -12.7272 ▁(0.131 -12.7274 chi -12.7279 ▁60.5 -12.728 ▁(391 -12.7284 {1-[2-( -12.7284 ▁(445 -12.7284 ▁0.208 -12.7285 ▁flush -12.7285 -1-[4- -12.7285 ▁2.5% -12.7286 −): -12.7286 thienylsulfonyl -12.7286 ▁53.7 -12.729 butanal -12.729 ▁60.2 -12.7291 ▁(5.75 -12.7291 ▁(4.64 -12.7291 ▁(3.83 -12.7293 ▁(418 -12.7293 XBridge -12.7298 [(2'- -12.7304 ▁(52%) -12.7307 bound -12.731 salicylaldehyde -12.731 ▁resolution -12.7311 ▁therefrom -12.7312 fluorophenethyl -12.7312 -1,2,3 -12.7313 ▁(3.71 -12.7314 iodoaniline -12.7315 ▁54.3 -12.7315 ▁ring -12.7316 8.47 -12.7316 13.2 -12.732 4,16- -12.7324 disulfide -12.7325 ▁(30.4 -12.7325 =10/1 -12.7326 ▁(27.7 -12.7329 ▁(3.89 -12.7331 ▁52.4 -12.7331 -4,12- -12.7334 ▁tetrahydrate -12.7336 ×4.6 -12.7338 ▁(28.1 -12.7341 4.76 -12.7342 ▁(3.77 -12.7344 ▁(4.56 -12.7347 ▁(55.0 -12.7353 [5-(3,5- -12.7354 ▁2-(2,3- -12.7354 ▁methyllithium -12.7357 ▁crushed -12.7359 ▁(6.25 -12.7361 3.56 -12.7364 ung -12.7368 ▁(43%) -12.7371 ▁(4.90 -12.7378 ▁50-100% -12.7378 ▁1:5 -12.738 ▁(97% -12.7382 ▁benzylbromide -12.7384 ▁(230-400 -12.7384 acetanilide -12.7385 ▁(0.230 -12.7389 ▁5-10 -12.7391 =14.3 -12.7393 ▁70.4 -12.7395 -4.50 -12.7395 =8.79 -12.7397 ▁46.7 -12.7401 89.0 -12.7403 -2-(2,4- -12.7404 {[2-(4- -12.7408 ▁(0.123 -12.7409 ▁0.275 -12.7409 ▁(30.6 -12.741 ▁0.230 -12.7413 ▁malononitrile -12.7415 ▁(0.240 -12.7417 cyanocyclopropyl -12.7419 ▁(4.33 -12.7419 ▁Ro -12.7419 ▁Harom -12.7422 ▁466 -12.7424 ▁2-(2,2- -12.7425 triacetoxy -12.7426 3.51 -12.7426 ▁DI -12.7426 2.87 -12.7427 ▁9.37 -12.7431 ][3] -12.7433 ▁44.3 -12.7435 ▁4-((2- -12.7436 ▁powdery -12.7436 -[1] -12.7437 [1,1- -12.7437 ▁9.78 -12.7438 ▁(4.76 -12.7438 ▁72.4 -12.7438 benzothiazepine -12.7439 )-(10 -12.7442 To -12.7444 ▁(4.17 -12.7446 ▁hydroquinone -12.7449 ▁7.46-7.5 -12.7456 ▁38.1 -12.7456 ▁464 -12.7456 ▁obscured -12.7458 )-1,1,1,3,3,3- -12.7458 -2,2,6,6- -12.7458 ▁0.140 -12.7459 ▁0.238 -12.7461 0.49 -12.7462 ▁(27.3 -12.7464 inate -12.7465 ▁9.41 -12.7466 ▁46.6 -12.7468 ▁(1:4) -12.7469 purified -12.747 ▁ethanethiol -12.7471 ▁(90:10 -12.7473 ▁(910 -12.7473 ▁0.157 -12.7474 propanamine -12.7475 ▁(28.2 -12.7477 ▁(1.000 -12.7477 ▁7.17-7.2 -12.7478 ▁triacetate -12.748 ▁(54%) -12.7481 ▁injection -12.7482 ▁refrigerator -12.7482 2,5,7,8- -12.7483 ▁OsO -12.7483 ▁51.2 -12.7484 ▁distillate -12.7486 ▁YMC -12.7488 ▁(341 -12.7488 OtBu -12.7489 trityloxy -12.7489 ▁(0.133 -12.7489 ▁0.171 -12.749 ▁9.90 -12.7493 ▁(4.26 -12.7495 ▁(4.86 -12.7497 butynyloxy -12.7501 ▁(0.124 -12.7503 ³ -12.7507 Acetoxy -12.7507 ▁HMPA -12.7507 ▁tributyltin -12.7508 NaOH -12.7511 {2-[(3- -12.7511 ▁53.3 -12.7515 ▁(44.0 -12.7515 ▁hept -12.752 ▁NaCN -12.752 ▁55.1 -12.7522 -{6-[ -12.7523 9.30 -12.7523 ▁(33.6 -12.7523 ▁deg -12.7524 ▁9.49 -12.7525 ▁sieve -12.7525 DMAP -12.7525 7.81 -12.7527 [[(4- -12.7529 ▁54.8 -12.7529 ▁(0.137 -12.753 ▁Teflon -12.7532 ▁stop -12.7532 -1-[3- -12.7535 ▁mixing -12.7535 ▁1-[4-(4- -12.7536 ▁app -12.7538 ▁(4.48 -12.7541 ▁2-[(3- -12.7543 ▁(0.118 -12.7544 71° -12.7548 {4-[(3- -12.7548 ▁4-(9- -12.7549 ▁44.8 -12.755 9.05 -12.7552 toluidine -12.7557 ring -12.7557 ▁51.4 -12.7558 ▁(3.94 -12.7558 ▁(4.23 -12.7561 butyrylamino -12.7561 ▁9.56 -12.7568 ▁449 -12.7569 ▁(40.5 -12.7569 cyanamide -12.7572 ▁(423 -12.7572 ▁Dur -12.7573 phenylglycine -12.7575 disulfanyl -12.7576 ▁7-(1- -12.7576 ▁7.47-7.4 -12.7578 ▁(32.6 -12.758 ▁isobutyryl -12.7581 {2-[(1 -12.7581 ▁126.7 -12.7582 ▁fluffy -12.7582 ▁radial -12.7582 =7.33 -12.7582 ▁0.197 -12.7586 bromobenzoyl -12.7601 ▁diethylene -12.7601 ▁(0.127 -12.7604 ▁9.84 -12.7606 oxohexanoate -12.7607 ',3'- -12.7607 dmso -12.7608 -4-(1-( -12.7608 -8-(1- -12.761 2,2,3,3- -12.761 3.86 -12.7614 54° -12.7621 3.77 -12.7621 thiazepin -12.7622 ▁58.0 -12.7623 =2.27 -12.7626 {[2-(2- -12.7628 methylpentanoate -12.763 ▁System -12.7631 ▁Collect -12.7632 Teledyne -12.7632 ▁isocyanide -12.7632 -4,8- -12.7634 =8.80 -12.7636 terphenyl -12.7637 =16.8 -12.7643 protected -12.7646 [3-(2,6- -12.7646 ▁(30.3 -12.7648 Dichlorophenyl -12.765 IX -12.765 ▁(0.117 -12.765 ▁Most -12.7657 -150° -12.7658 quinolone -12.7659 ▁54.7 -12.7659 ▁(4.27 -12.766 8.78 -12.7661 ▁38.2 -12.7662 ▁56.8 -12.7662 ▁(30.2 -12.7664 ▁52.3 -12.7671 ▁{6- -12.7672 ▁(7:3 -12.7673 ▁0.179 -12.7677 ▁(5.05 -12.7678 ▁(26.1 -12.768 ▁Rochelle -12.7683 ▁cycles -12.7683 ▁10-15° -12.7683 ethynylphenyl -12.7685 picolinamid -12.7691 -[6-(3- -12.7695 ]-1-(2- -12.7697 8.66 -12.7697 ▁9.83 -12.7702 {2-( -12.7704 3.69 -12.7705 minutes -12.7707 ▁known -12.7708 36° -12.7709 -[2,4- -12.771 ▁133.2 -12.771 ▁2,3,4- -12.7711 ▁(373 -12.7713 ▁eliminated -12.7717 ▁neutralize -12.772 ▁0.194 -12.7721 ▁(0.147 -12.7724 ▁9.57 -12.7725 )-1-[3,5- -12.7726 ▁0.244 -12.7732 ▁130.3 -12.7733 ▁40-45° -12.7733 ▁chromium -12.7734 ▁continuously -12.7734 ▁(438 -12.7734 9.06 -12.7734 decyloxy -12.7736 44° -12.7736 6.31 -12.7737 ▁ground -12.7738 Benzotriazol -12.7739 ▁61.8 -12.7743 ulph -12.7744 ▁(411 -12.7747 -2-(5-( -12.7747 ▁(0.144 -12.7748 ▁(465 -12.7749 ▁(4.88 -12.7749 6.50 -12.7751 ▁(5.45 -12.7752 ▁7.49-7.5 -12.7752 -3-[3- -12.7752 [4-(2,3- -12.7753 -4-[1- -12.7754 ▁chlorine -12.7759 3.67 -12.776 ▁54.9 -12.7761 ▁barium -12.7762 ▁444 -12.7763 ▁0.193 -12.7763 ▁48.2 -12.7764 ▁49.2 -12.7764 ▁57.9 -12.7767 Water -12.7767 ▁130.4 -12.7771 ▁diazonium -12.7771 ▁generated -12.7774 ▁(4.07 -12.7774 ▁oxetan -12.7775 ▁(28.7 -12.7775 ▁40.4 -12.7775 ▁7.37-7.2 -12.7777 pi -12.7777 -4-[(2- -12.7778 ▁(33.3 -12.7778 90° -12.7779 ▁(485 -12.778 0:10:1 -12.7781 }-4-( -12.7783 oxazepane -12.7787 11.0 -12.7787 ▁0.161 -12.779 ▁(24.1 -12.779 ▁7.09-7.1 -12.7791 available -12.7799 ▁(426 -12.78 cyclohexa -12.78 ▁(27.9 -12.7801 ▁4-((3- -12.7801 ▁9.73 -12.7808 ▁plus -12.781 borono -12.7811 ▁50-55° -12.7812 ▁47.7 -12.7814 99° -12.7815 ▁(23.1 -12.7815 isocyano -12.7816 {4-[3-( -12.7817 -[4-(3,4- -12.7818 ▁[1-(2- -12.7819 Bn -12.782 ,8,9,10,11,1 -12.7822 ▁7.47-7.5 -12.7823 ▁(4.37 -12.7827 6.59 -12.783 eter -12.7832 ▁Thio -12.7835 ▁selenium -12.7835 ▁50.5 -12.7838 ▁thiomorpholine -12.7839 ▁46.3 -12.7842 =14.1 -12.7844 7.64 -12.7846 ▁NaOEt -12.7846 ▁(319 -12.7847 ▁(3.49 -12.7848 ▁220° -12.7848 ▁(393 -12.7849 ▁9.54 -12.785 pivaloyloxy -12.785 ▁7.55-7.5 -12.7853 ▁2-[1- -12.7853 ▁54.2 -12.786 [1,2,3- -12.7861 ▁-65° -12.7861 49° -12.7862 ▁0.169 -12.7864 naphthoyl -12.7867 ▁65.0 -12.7868 ▁(28.9 -12.7868 ▁0.209 -12.7869 )-5-[3,5- -12.787 undecene -12.7871 isoxazolo -12.7872 dimethy -12.7872 5.5% -12.7875 ▁(27.4 -12.7877 0.3% -12.7878 ,5,9 -12.788 hiosemicarbazide -12.7883 800 -12.7884 ▁Company -12.7887 ▁supra -12.7887 ▁0°-5° -12.7889 ▁0:1 -12.7893 ▁52.1 -12.7894 butanamido -12.7894 ▁38.3 -12.7895 ▁126.6 -12.7896 ▁172.8 -12.7897 ▁39.1 -12.7898 fluoroquinolin -12.7902 ▁(0.164 -12.7903 +23) -12.7903 ▁41.9 -12.7904 ▁(44%) -12.791 amic -12.791 octadecyl -12.7911 ▁9.89 -12.7913 8.69 -12.7914 {2-[(4- -12.7915 ▁coloured -12.7915 MW -12.7917 ▁therein -12.7918 ▁9.66 -12.7918 ▁(0.195 -12.7922 ▁(+)-(4 -12.7923 ethy -12.7929 ▁54.0 -12.7932 ▁9.70 -12.7933 13.1 -12.7933 ▁0.276 -12.7934 ▁-70 -12.7937 ▁0.141 -12.7937 ▁Imidazole -12.7939 -4-[4-(4- -12.7939 cinnoline -12.7942 ▁propylene -12.7942 ▁(0.210 -12.7945 ▁456 -12.7945 8.61 -12.7946 propargyl -12.7946 benzoxepin -12.7947 ▁(41.5 -12.7948 6.3% -12.7951 -6-(4-( -12.7952 three -12.7954 -1.78 -12.7957 ▁preheate -12.7957 ▁7.70-7.6 -12.7957 ▁9.95 -12.7957 ▁50:1 -12.7958 ▁40.7 -12.7958 hexahydrofuro -12.796 ▁0.217 -12.7964 ▁(10%-99% -12.7965 ▁HOAT -12.7965 ▁diluting -12.7965 ▁20:80 -12.7967 BrF -12.7967 tetrahydrothieno -12.7968 -{2-[5- -12.797 ▁7.43-7.4 -12.797 ▁Synthetic -12.7971 ×75 -12.7972 19.0 -12.7973 ▁dil -12.7974 ▁60.9 -12.7979 -3.60 -12.7986 {2-[2-( -12.7986 cat -12.7987 osyl -12.7988 -3-[(3- -12.7988 ,5,6,7,8, -12.7989 (1,1,1,3,3,3- -12.7991 ture -12.7992 ▁methanesulphon -12.7993 ▁0.256 -12.7993 ▁(15.00 -12.7993 ▁Gel -12.7994 iodobenzyl -12.7996 ▁49.4 -12.7997 ▁461 -12.7999 ▁(455 -12.8003 ▁9.68 -12.8003 -6-(1 -12.8005 chloronicotinic -12.8005 Petroleum -12.8006 ▁(5.35 -12.8008 14.0 -12.8009 ▁48.9 -12.801 -2-[(3- -12.8012 ▁3-[4-(4- -12.8012 ame -12.8013 -15- -12.8013 =1:4 -12.8019 ▁170.9 -12.802 ▁0.187 -12.802 ▁0.220 -12.8023 ▁dispersed -12.8023 ▁thioacetate -12.8024 ▁(30.8 -12.8024 ▁9.87 -12.8024 ▁0.600 -12.8025 ▁(45%) -12.8027 -[[3- -12.803 1,3,3- -12.8031 ▁58.5 -12.8035 ▁Vol -12.8036 ▁1:10 -12.8037 ▁9.47 -12.8038 pivalamide -12.8043 ▁KHMDS -12.8043 bulb -12.8043 ▁0.170 -12.8046 ▁4-[3-(4- -12.8048 ▁63.6 -12.8051 ▁4-(2,6- -12.8052 ▁0.149 -12.8052 ▁(38.5 -12.8055 ▁4-[[ -12.8059 ▁(6.15 -12.806 triamine -12.8065 ▁85:15 -12.8069 ▁appeared -12.8069 ▁mercuric -12.8069 ▁third -12.8069 Ethynyl -12.8069 sulfane -12.807 -2,1,3- -12.807 dibenzofuran -12.807 ▁0.254 -12.807 0.05% -12.8073 chol -12.8073 ▁75.0 -12.8076 ▁(35.5 -12.8078 ▁(0.146 -12.8079 dihydrodibenzo -12.808 isopropylsilanyl -12.8082 ▁4-[2-(2- -12.8084 ▁7.58-7.5 -12.8085 chem -12.8085 ▁4-[(6,7- -12.8086 ▁57.5 -12.8088 anol -12.809 ▁(0.800 -12.8091 ▁(4.13 -12.8092 -5(1 -12.8093 ▁5-(3,4- -12.8093 ▁7.34-7.4 -12.8093 salicylate -12.8095 ▁Iodine -12.8096 ▁overhead -12.8096 ▁resonance -12.8096 ▁succession -12.8096 ▁0.0005 -12.8096 ▁causing -12.8096 ((2,4- -12.8098 ▁60:40 -12.8102 ▁0.268 -12.8102 -5-(6- -12.8104 =8.46 -12.8105 ▁comp -12.8108 Carbo -12.811 eck -12.8112 10.2 -12.8113 propylphosphonic -12.8114 ▁pentafluorophen -12.8115 8.95 -12.8118 ▁64.0 -12.8119 ,2,5- -12.8121 ― -12.8122 glutari -12.8122 ▁4.6×50 -12.8123 -4-(2,2- -12.8123 8.58 -12.8124 ▁Filtered -12.8125 8.49 -12.8129 ▁Degussa -12.8131 ▁8-9 -12.8132 ▁4,5,6,7- -12.8134 ▁KCN -12.8137 ▁62.4 -12.8138 Tert -12.8138 tartrate -12.8138 ▁[1-( -12.8139 ▁millimoles -12.814 =4:1 -12.814 ▁59.7 -12.8141 formylbenzoate -12.8142 dideoxy -12.8151 ▁52.2 -12.8153 ▁61.3 -12.8154 ▁43.0 -12.8154 ▁132.2 -12.8154 ,9,10- -12.8156 dichloroaniline -12.8157 )-1-((3 -12.8159 ▁(88% -12.8159 [2,4- -12.8163 PdCl -12.8164 ▁(5.12 -12.8168 ▁4-(2,3- -12.8169 ▁(386 -12.8173 ▁phosphonium -12.8173 glutamic -12.8173 methyloxetan -12.8173 ribofuranosyl -12.8175 -2,3,5,6- -12.8175 ▁shaker -12.8175 pyruvate -12.8175 ize -12.8176 phenothiazine -12.8177 (4,4,4- -12.8179 ▁0.288 -12.818 ▁45.9 -12.818 5.30 -12.8181 -1-(2-( -12.8182 ▁46.8 -12.8183 3:1 -12.8189 ▁447 -12.8191 Gradient -12.8191 ▁494 -12.8192 ▁bromoacetyl -12.8193 )-1-{( -12.8195 ▁0.199 -12.82 benzothiazepin -12.8201 ▁2-(6-( -12.8201 ▁finished -12.8202 ▁(5.40 -12.8202 ▁7%) -12.8207 ence -12.8211 ▁66.2 -12.8216 ▁epichlorohydrin -12.8217 )-3-{[ -12.8218 saccharin -12.8219 isochroman -12.8224 0.71 -12.8225 ▁9.76 -12.8227 ▁perchlorate -12.8228 0-99% -12.823 ▁(35.6 -12.8231 enenitrile -12.8232 ▁1-(4-(4- -12.8239 ▁7.56-7.5 -12.8239 Pyrrolidin -12.824 -[[2-( -12.8241 [1-(3,4- -12.8242 [(2,5- -12.8242 -1,2, -12.8243 NHCH -12.8245 preparative -12.8245 oside -12.8247 butanenitrile -12.8249 ▁(396 -12.825 :0.1 -12.8251 ▁49.6 -12.8251 /0.05% -12.8254 ▁(0.215 -12.826 ▁(0.168 -12.8261 ▁59.5 -12.8262 5_ -12.8265 ▁7.62-7.5 -12.827 {4-[1- -12.827 difluoroacetic -12.827 -1-[( -12.8272 off -12.8272 }-3-( -12.8273 ▁63.1 -12.8276 5.99 -12.8278 -[2,6- -12.8281 ▁61.2 -12.8281 ▁7.52-7.5 -12.8282 ▁47.8 -12.8282 ▁analyses -12.8282 ▁bomb -12.8282 ▁weighed -12.8282 ▁64.6 -12.8282 7.49 -12.8282 THP -12.8283 ke -12.8283 acetylpiperazin -12.8284 -3,17- -12.8285 ▁MCPBA -12.8286 (4-((6- -12.8287 ▁53.1 -12.8288 ▁(5.13 -12.8288 ▁5-(3,5- -12.829 ▁(394 -12.829 ▁10.97 -12.8291 pyrimidinedione -12.8292 war -12.8295 ▁495 -12.8298 ortho -12.8299 ▁confirm -12.8307 ▁49.0 -12.8308 [2,6] -12.8309 ▁started -12.8309 ▁(34.8 -12.831 ▁43.7 -12.8311 /60 -12.8313 ▁(4.57 -12.8317 -[1-[ -12.8319 thiocarbonyldi -12.832 ▁Benzo -12.8321 [(1,3- -12.8324 ▁FIG -12.8325 ▁0.267 -12.8327 ▁7.57-7.5 -12.8327 ▁3×50 -12.8329 ▁trace -12.833 ▁486 -12.8331 -5-((4- -12.8331 ▁0.234 -12.8331 ▁37.9 -12.8332 methionine -12.8336 ▁number -12.8336 ▁last -12.8336 ▁transparent -12.8336 8.80 -12.8336 naphthaldehyde -12.8336 gassed -12.8336 ▁(92% -12.8339 ▁59.4 -12.834 ▁(3.39 -12.8341 [1-(6- -12.8346 ▁50.4 -12.8348 -[3-(1- -12.835 ▁62.8 -12.8352 ▁47.2 -12.8357 ▁dimethylsulfide -12.8358 ▁9.63 -12.8358 ▁(417 -12.8359 ▁59.2 -12.8359 ▁72.5 -12.836 9.00 -12.836 ▁62.0 -12.8365 ▁Enantiomer -12.8368 =16.5 -12.8369 ▁10-15 -12.8372 -9-(3- -12.8374 ▁(3.69 -12.8375 ▁1-(2-(4- -12.8377 ▁57.6 -12.8382 ▁(±)-( -12.8388 3.59 -12.8389 ▁0.214 -12.8389 ▁Pyrrolidine -12.839 ▁IMS -12.839 butylisoxazol -12.8391 ▁ISP -12.8391 -2-[4-(4- -12.8393 ▁(299 -12.8394 (100 -12.8394 ▁0-60% -12.8396 ▁9.98 -12.8397 ▁(96% -12.8398 ▁126.0 -12.8399 ▁60.3 -12.84 light -12.84 ▁0.264 -12.8401 ▁57.4 -12.8402 ▁aryl -12.8402 ▁4,4'- -12.8403 polar -12.8407 quant -12.8408 ▁methylester -12.8408 tolylsulfonyl -12.841 cyclohexylidene -12.8411 lactic -12.8413 ▁PCl -12.8413 ▁66.7 -12.8413 prolinamide -12.8417 ▁thiophosgene -12.8417 ▁(0.148 -12.8421 ▁(51%) -12.8421 ▁53.8 -12.8425 ▁2-(5-( -12.8426 Select -12.8426 ▁Petroleum -12.8428 )-2-(1,3- -12.843 ▁7.33-7.4 -12.8431 ▁53.0 -12.8431 8-(2,6- -12.8435 ▁(4.44 -12.844 ▁Work -12.8442 ▁conventional -12.8444 ▁58.6 -12.8444 ▁(0.111 -12.8446 ▁diastereomeric -12.8447 2,2- -12.8449 =9/1 -12.8452 ▁125.5 -12.8452 ▁53.2 -12.8453 {4-[6- -12.8453 ▁60.8 -12.8454 ▁0.287 -12.8455 quinuclidine -12.8456 ▁0.240 -12.8457 ▁467 -12.8459 5.2% -12.8463 ,7,7- -12.8466 ▁Aluminum -12.8471 ascorb -12.8471 ▁57.7 -12.8474 ▁(4.84 -12.8474 ▁Merck -12.8476 =16.2 -12.8476 han -12.8477 Prep -12.8478 ▁(0.205 -12.8478 ▁7.19-7.1 -12.8479 ▁63.2 -12.8479 ▁7.18-7.1 -12.8479 ▁(0.167 -12.848 -4-[(1 -12.848 ▁52.9 -12.848 tetralin -12.8482 ▁(0.134 -12.8482 ▁7.53-7.4 -12.8485 uric -12.8486 ▁γ -12.849 IPA -12.849 Trimethyl -12.8491 ▁(33.4 -12.8491 ▁56.7 -12.8497 cyclooctadiene -12.8499 9.80 -12.8499 anhydro -12.8499 ]-1'- -12.85 cap -12.85 ▁69.8 -12.8505 ▁7.46-7.3 -12.8506 ▁0.190 -12.8508 -4-((2- -12.851 fur -12.851 ▁(4.38 -12.8511 ,5,6,6 -12.8513 azin -12.8513 itric -12.8525 izing -12.8525 ▁9.77 -12.8526 Nujol -12.8526 ▁week -12.8526 eginning -12.8526 ▁cerium -12.8526 ▁development -12.8526 ▁7.57-7.6 -12.853 ▁40.2 -12.853 9.19 -12.8532 ▁NaOtBu -12.8534 dimethylglycine -12.8535 ▁(3×1 -12.8535 Oct -12.8537 ▁0.260 -12.8537 ▁1-(8- -12.854 ▁49.7 -12.8541 -2,3,6 -12.8542 dioxolo -12.8543 ▁(3.91 -12.8544 =15.0 -12.8544 propylphenoxy -12.8545 ▁(349 -12.8546 ]-6-(4- -12.8549 ▁(4×100 -12.8553 sulfoxonium -12.8554 ▁8%) -12.8555 ok -12.8558 {3-[4-( -12.8559 ▁50.6 -12.8559 vinyloxy -12.856 51° -12.8561 ▁4-[6- -12.8562 ▁6:1 -12.8563 ▁(416 -12.8567 major -12.8572 inium -12.8573 ▁[3-(2- -12.8573 ▁(35.2 -12.8577 ▁(397 -12.8581 ▁condensation -12.8582 ▁(374 -12.8587 ▁50.7 -12.8588 ple -12.8589 ▁20-100% -12.8592 ▁ArCH -12.8592 ▁474 -12.8595 ▁(3.51 -12.8596 -4-[4-(2- -12.8601 ▁(0.158 -12.8603 ×40 -12.8605 8.79 -12.8605 3.66 -12.8609 myelement -12.8609 ▁60-65° -12.8609 ▁First -12.8609 ▁bond -12.8609 ▁0.226 -12.8611 ▁(44.5 -12.8611 ▁44.7 -12.8613 -1-[(3 -12.8615 ▁7.17-7.1 -12.8615 ▁7.60-7.6 -12.8616 ▁(4.54 -12.8616 ▁0.257 -12.8616 [4′- -12.8619 chloronicotinate -12.8622 benzothieno -12.8626 chloroacetamido -12.8627 ▁(93% -12.8628 -[2-[( -12.8633 ▁Tf -12.8635 (2′,6′- -12.8636 ▁Kugelrohr -12.8637 ▁carry -12.8637 3',4'- -12.8637 furfuryl -12.8637 quart -12.8637 ▁(381 -12.864 ▁49.8 -12.8641 ▁44.5 -12.8643 ▁working -12.8645 flu -12.8645 =0.0 -12.865 ▁JCF -12.8654 6.29 -12.8656 ▁(2,5- -12.8659 ▁0.219 -12.866 ▁(34.7 -12.866 ▁41.1 -12.866 ▁ligand -12.8665 ▁(26.9 -12.8667 -5-(2-( -12.867 ▁(35.7 -12.867 ▁(1×10 -12.8674 hydroxyazetidine -12.8674 7.74 -12.8674 ▁9.61 -12.8675 ▁(0.166 -12.8675 propio -12.8675 ▁49.3 -12.8681 =100:1 -12.8683 ▁(35.4 -12.8683 ▁59.1 -12.8687 Indol -12.8687 pped -12.8687 Nitrophenyl -12.8689 ▁spectroscopic -12.8689 ▁(5.56 -12.8689 ▁pentahydrate -12.8693 azoniabicyclo -12.8693 ▁sintered -12.8693 ▁(0.176 -12.8695 ▁(535 -12.8696 ▁9.96 -12.8697 fu -12.8698 ▁formamidine -12.8698 ▁0.277 -12.8699 5.8% -12.87 ▁(32.7 -12.87 ▁1.80-1.9 -12.87 -3.50 -12.8706 dodecan -12.8707 piperidinium -12.8707 ▁53.9 -12.8713 8.90 -12.8714 '-(4- -12.8714 ▁4-{4- -12.8715 ▁7.59-7.5 -12.8716 [6-(3- -12.8718 -160° -12.8718 =1:3 -12.8719 succinimidyl -12.8721 ▁distributed -12.8721 5.66 -12.8722 dimethoxyaniline -12.8723 cinnamoyl -12.8723 ▁obs -12.8724 ▁2-(1,3- -12.8729 oxathiazepin -12.8729 ▁9.44 -12.8731 ▁(31.7 -12.8731 ▁(428 -12.8731 ▁51.3 -12.8731 diethoxyethyl -12.8735 ▁52.7 -12.8742 (2' -12.8743 ▁(34.3 -12.8744 Ex -12.8747 ▁(575 -12.8748 ▁131.6 -12.8748 ▁Varian -12.8749 ▁desiccant -12.8749 her -12.8749 Allyl -12.8751 ▁0-25% -12.8752 ▁(86% -12.8757 diborane -12.8758 ▁7.12-7.1 -12.8759 ▁9.72 -12.8761 ▁115.2 -12.8761 ▁125.9 -12.8763 ▁5-{ -12.8766 ▁69.0 -12.8767 ▁cyclopentanone -12.8767 ▁[2-(3- -12.8771 dibenzyloxy -12.8773 ▁69.1 -12.8774 ▁Quench -12.8777 ▁become -12.8777 ▁(0.139 -12.8777 ▁63.9 -12.878 naphthoate -12.8781 esi -12.8783 ▁(3.61 -12.8785 ▁7.16-7.1 -12.8785 :1:0.1 -12.8786 ▁60.6 -12.8789 ▁545 -12.8789 formylphenoxy -12.879 ▁(379 -12.8797 [2-(1,3- -12.8797 ▁47.5 -12.8797 ▁(5.70 -12.8805 -2,1′- -12.8805 trimethylstannyl -12.8805 butadiene -12.8805 ▁consecutively -12.8805 {2-[4-(4- -12.8805 ▁7.55-7.4 -12.8806 ▁liquors -12.8807 =14.2 -12.8808 triol -12.881 -2,3,4- -12.8811 ▁7.51-7.5 -12.8812 (2-{[ -12.8815 ▁3-[2-( -12.8815 ▁4-{[( -12.8817 vac -12.8817 ▁(34%) -12.8819 -2-[2-(4- -12.8821 ▁64.2 -12.8823 ▁72.3 -12.8826 ▁(371 -12.8828 difluoroethoxy -12.8828 ▁44.1 -12.8831 leucyl -12.8833 glucopyranoside -12.8834 ▁attached -12.8834 ▁release -12.8834 =2:1 -12.8836 ▁60.4 -12.8841 ▁64.3 -12.8841 ▁7.12-7.0 -12.8843 ▁acet -12.8844 diisopropylether -12.8852 ▁9.86 -12.8858 succin -12.8859 ▁3-[1- -12.886 Fuji -12.8862 ▁have -12.8862 ▁INT -12.8865 ▁0.228 -12.8866 benzhydryloxy -12.8866 ▁62.2 -12.8867 {2-[2- -12.887 ▁(5.14 -12.8872 ▁(27.1 -12.8873 ▁59.6 -12.8875 ▁9.64 -12.8876 propynyloxy -12.888 hydrazone -12.8882 tetradecan -12.8883 ▁necked -12.8883 ▁(0.186 -12.8884 ▁route -12.889 -1,3,5(10)- -12.8891 ▁66.4 -12.8892 69° -12.8893 ▁MeNH -12.8894 ▁3-[2-(4- -12.8895 vol -12.8896 ▁57.1 -12.8896 ▁ole -12.8897 ▁MPa -12.8899 ▁(990 -12.8901 ▁[(4- -12.8901 (8-( -12.8906 ▁(31.3 -12.8911 analysis -12.8911 ▁0.181 -12.8911 ▁0.318 -12.8912 ▁48.1 -12.8913 ▁62.6 -12.8917 ▁61.6 -12.8918 ▁render -12.8919 ▁Dowex -12.8919 ▁incomplete -12.8919 ▁shaking -12.8919 [1.1.1] -12.8919 catechol -12.8919 ▁Distillation -12.8919 ▁(0-40% -12.892 acridine -12.8922 ▁46.9 -12.8922 ▁6-(2,6- -12.8927 ▁7.24-7.1 -12.893 ▁0.306 -12.893 ▁(4.93 -12.893 ▁Per -12.893 ▁(0.141 -12.8932 ▁0.304 -12.8933 ▁(82% -12.8933 ▁methacryl -12.8935 ▁9.88 -12.8935 ▁(400.0 -12.8938 ▁0.248 -12.8939 ▁3-(8- -12.8942 py -12.8942 Methode -12.8944 ▁und -12.8947 3.57 -12.895 gas -12.8951 oxobutyrate -12.8953 OBzl -12.8953 comp -12.8955 5.75 -12.8957 Benz -12.8959 ▁126.2 -12.8963 ▁(37.0 -12.8964 EZ -12.8966 8.51 -12.8973 [4′,3′:6,7] -12.8976 /5% -12.8976 ((1-(3- -12.8977 phthalide -12.8977 ▁(89% -12.898 ▁RB -12.898 12.3 -12.8981 ▁70.5 -12.8984 ime -12.8986 =50:1 -12.8986 ▁(0.260 -12.8992 {1-[3-( -12.8993 ▁Solution -12.9005 ▁preferably -12.9005 ▁9.79 -12.9008 ▁47.3 -12.901 yst -12.9013 ▁7.15-7.1 -12.9015 ▁51.0 -12.902 ▁4′-{[4- -12.9022 ▁10,11- -12.9024 ▁10.15 -12.9024 ▁10.25 -12.9024 ▁0.266 -12.9025 thioate -12.9026 (2-((3- -12.9034 ▁131.8 -12.9034 Benzoyl -12.9035 ▁bor -12.9035 ▁7.56-7.6 -12.9037 1,2,3,4,5,6- -12.9039 trideca -12.904 ▁123.8 -12.9041 ▁7.08-7.1 -12.9042 ▁7.38-7.2 -12.9044 ,4'- -12.9044 ▁maleate -12.9045 imidazolium -12.905 4.86 -12.905 ▁(3.59 -12.9051 filtered -12.9056 -(4-(5-( -12.9059 ▁Grams -12.9063 ▁signals -12.9064 ▁126.3 -12.9065 -2,1- -12.9066 ▁rose -12.9066 ▁0.216 -12.9069 8.67 -12.9069 PT -12.9071 ▁EP -12.9071 ▁124.1 -12.9074 ▁Torr -12.9077 ▁(34.4 -12.9079 ▁590 -12.908 decanoyl -12.9084 ▁(625 -12.9085 ▁0.281 -12.9087 ▁[5-(4- -12.9089 ▁0.295 -12.909 ▁7.55-7.6 -12.9092 ▁132.1 -12.9092 ▁enough -12.9092 prolyl -12.9093 (6-(1- -12.9093 ▁66.1 -12.9096 ▁post -12.9097 ▁65.5 -12.91 acryl -12.91 ▁thionylchloride -12.9102 (1-((2-( -12.9103 ▁(25.9 -12.9104 ▁(0.204 -12.9104 stirred -12.9108 -3-((2-( -12.9108 ▁(498 -12.9111 3.61 -12.9111 chloropurine -12.9111 ▁(466 -12.9112 furanone -12.9115 =6.57 -12.912 ▁130.7 -12.912 ▁Isomer -12.9122 ▁PTSA -12.9122 ▁43.9 -12.9125 glu -12.9125 5,5,5- -12.9128 ▁(29.8 -12.9129 ▁[1-(3- -12.9129 ,10,10 -12.9129 ▁propionaldehyde -12.9131 ▁0.384 -12.9133 ▁(43.5 -12.9138 ▁68.5 -12.914 8.85 -12.9141 sulphoxide -12.9143 +]+= -12.9146 10.3 -12.9147 2,2,3,3,3- -12.9151 ▁10/90 -12.9151 -3-[2-(2- -12.916 ▁(0.178 -12.916 ▁7.14-7.1 -12.9161 =9:1 -12.9165 ▁(0.375 -12.9165 ▁(1:0 -12.9166 ▁(29.3 -12.9167 ral -12.9172 ethylimino -12.9172 -2-(3,5- -12.9173 -5-(2,4- -12.9175 ▁64.9 -12.9176 2′,3′ -12.9176 ▁homogenous -12.918 ▁60-120 -12.918 ▁(4.74 -12.9185 ▁0.316 -12.9188 perfluoro -12.919 ▁125.4 -12.9192 ▁acidification -12.9193 ▁(467 -12.9193 ▁9%) -12.9194 ▁9.94 -12.9195 ▁(98:2 -12.9199 pentene -12.9202 ▁40.1 -12.9203 ▁0.274 -12.9205 ▁contains -12.9206 {4-[4-(4- -12.9206 ▁4-(1-(4- -12.9207 ▁mercury -12.9209 tryptophan -12.921 Aza -12.921 ▁fritted -12.921 ▁methacrylate -12.921 [1,2 -12.9212 =16.1 -12.9214 ▁(398 -12.9214 ▁glassy -12.9215 ▁0.229 -12.9215 ▁7.61-7.5 -12.9219 prep -12.922 16.0 -12.9225 cyclohexanedione -12.9228 {3-[(1 -12.9228 mono -12.9229 ▁generate -12.9229 ▁(150.0 -12.923 ▁70.3 -12.9231 ▁7.40-7.2 -12.9232 ▁126.1 -12.9235 ▁45.1 -12.9236 ▁Initiator -12.9239 ▁entire -12.9239 ▁471 -12.924 14.3 -12.9241 dicyclopropyl -12.9241 bromopropionate -12.9243 ▁glyoxal -12.9244 350 -12.9246 78.5 -12.925 ▁(488 -12.925 ▁(87% -12.9257 ▁NMO -12.9258 ▁3,7- -12.9259 ▁TMSCl -12.9263 ▁(38.4 -12.9265 ▁47.1 -12.927 aminium -12.927 1,2,2- -12.9272 -105° -12.9273 azidoethyl -12.9276 ×500 -12.9278 ▁498 -12.9281 5-100% -12.9281 ▁0.265 -12.9283 isopropylidene -12.9283 ▁˜5 -12.9283 ▁(36.4 -12.9285 ▁(5.76 -12.9295 ethanesulfonic -12.9296 ▁64.8 -12.9298 ▁Bio -12.9298 ▁cyanur -12.9299 *,5 -12.9301 diethylaniline -12.9301 See -12.9302 dimethylethane -12.9302 sulphate -12.9302 ▁0.278 -12.9303 6.8% -12.9303 [2] -12.9305 ▁125.7 -12.9308 ▁CEM -12.9309 ▁(46.0 -12.9311 3.71 -12.9312 ▁7.59-7.6 -12.9312 ▁71.3 -12.9313 ▁0.237 -12.9316 ▁0.348 -12.9325 ▁66.5 -12.9328 carbamothioyl -12.9328 ▁simultaneously -12.9328 -[2,4′ -12.9328 ▁(34.2 -12.9331 ▁4-(2,2- -12.9332 0-75% -12.9333 thiadiazine -12.9337 ▁40.9 -12.9338 ▁trimethylamine -12.9338 ▁(361 -12.9339 ▁3-(4,4,5,5- -12.9342 Ser -12.9343 morpholinothieno -12.9344 =14.5 -12.9346 ▁(39.5 -12.9347 ▁59.9 -12.9348 ▁65.1 -12.9348 ▁70.9 -12.9357 ▁(0.156 -12.937 10.5 -12.9372 3.8% -12.9376 ▁0.269 -12.9376 ▁65.4 -12.9379 ▁0.236 -12.9379 ▁particle -12.9379 ▁(36.6 -12.938 ▁(78% -12.938 ▁3-[4-(2- -12.9383 bromobutyrate -12.9384 (3,3,5,5- -12.9388 Electrospray -12.9388 ▁Pour -12.9389 dihydroisoxazole -12.9392 ▁9.69 -12.9393 ▁6,8- -12.9393 =5.05 -12.9402 ▁47.4 -12.9407 chrom -12.9408 reatment -12.9408 ▁forming -12.941 retention -12.9411 cyclobutoxy -12.9414 ▁3-{3- -12.9415 ▁turbid -12.9418 ▁130.8 -12.9418 9.36 -12.9419 ▁Organics -12.942 ▁(34.6 -12.942 ▁(48.0 -12.9423 ▁477 -12.9423 iphenylmethylene -12.9426 cyanide -12.9426 pentenyl -12.9427 ▁9.81 -12.9427 ▁58.4 -12.943 ▁63.7 -12.9434 ▁(33.7 -12.9438 dichloropyrazine -12.9441 yi -12.9441 ▁70.8 -12.9442 ▁(32.2 -12.9445 Diazabicyclo -12.9448 ▁131.2 -12.9448 -7,3′- -12.9448 ▁Afterwards -12.9448 ▁citrate -12.9448 ▁scintillati -12.9448 -[1,2′] -12.9448 ▁Wako -12.9448 ▁pentasulfide -12.9448 ▁40-50° -12.9448 ▁forward -12.9448 iodophenol -12.9448 ▁64.7 -12.9449 ▁98/2 -12.945 ▁0.231 -12.9452 ▁(45.6 -12.9456 ▁47.0 -12.9458 ▁(436 -12.9465 ▁7.54-7.4 -12.9467 ▁(0.190 -12.9468 thiocarbamoyl -12.9473 ▁(“ -12.9476 ▁checked -12.9478 GC -12.9479 ▁(52.5 -12.948 ▁61.9 -12.9485 (2-((1 -12.9485 ▁2.05-1.9 -12.9486 ▁OMe -12.9491 ▁123.7 -12.9502 ×300 -12.9503 ▁6-[( -12.9506 ▁rotavap -12.9508 sulphur -12.9508 maleimide -12.9509 ▁1,1,3,3- -12.9511 ▁0/100 -12.9511 propanedioate -12.9511 -6-[(3 -12.9522 ▁630 -12.9528 ▁mentioned -12.9536 enic -12.9536 Chiralpak -12.9539 ▁metabisulfite -12.9539 ▁moisture -12.9539 ▁scale -12.9539 azocine -12.9541 04) -12.9544 ▁(38%) -12.9544 ▁73.5 -12.9544 ▁9.74 -12.9545 3,4,6,7,8,9- -12.9546 ▁(464 -12.9548 ▁pellets -12.955 =15.2 -12.9551 ▁(33.8 -12.9554 -2',6'- -12.9555 stan -12.956 ▁(3×250 -12.9562 ▁7.44-7.5 -12.9564 ey -12.9567 ▁Buchner -12.9569 ▁XantPhos -12.9569 ▁60.1 -12.9569 ▁(32.8 -12.9573 ▁state -12.9573 1,2,4,5,6,7 -12.9573 thioacetamide -12.9574 ▁Elut -12.9577 lacial -12.9577 ▁7.05-7.1 -12.9578 ▁130.9 -12.958 ▁65.3 -12.9583 ▁58.9 -12.9587 propionyloxy -12.9588 undeca -12.959 enal -12.959 Chloroper -12.9596 ▁signal -12.9598 Agilent -12.96 ▁(4.29 -12.9603 -5-[(2- -12.9603 ▁(0.177 -12.9604 8-[(2,6- -12.9608 hexanamide -12.9608 =95:5 -12.9614 ▁10.05 -12.9615 2,2,2- -12.9622 @ -12.9624 synthesized -12.9624 acidic -12.9628 ▁0.227 -12.9628 part -12.9628 ▁-30 -12.9629 ▁rapid -12.963 ▁0.0006 -12.9631 ▁(30.1 -12.9632 ▁finely -12.9632 ▁66.0 -12.9632 -[(4,6- -12.9633 -5,4′- -12.9634 ▁recooled -12.9635 ▁(33.2 -12.9637 rr -12.9639 -3-(3′- -12.9641 1,5,6,7- -12.9642 ▁72.6 -12.9643 iPr -12.9644 -7-(( -12.9645 ▁10-50% -12.9646 ▁9.93 -12.9648 ▁54.4 -12.9648 ▁64.1 -12.9649 ▁½ -12.9652 trifl -12.9653 ▁KP -12.9654 ▁(0.700 -12.9655 rhodium -12.9655 ▁69.7 -12.9656 ▁45.3 -12.9656 mann -12.9657 ▁(37.8 -12.966 ▁lyophil -12.9661 2,3,5,6,7,8- -12.9661 [12.3.1.02,6] -12.9661 ▁Platinum -12.9661 ▁inner -12.9661 ▁DABCO -12.9661 ▁EDTA -12.9661 ▁Xterra -12.9661 ▁dichromate -12.9661 ▁1,2,3- -12.9661 ▁revealed -12.9662 [6-(1- -12.9662 ▁80-90° -12.9663 ▁570 -12.9665 dipropylamino -12.9669 ▁9.59 -12.9671 ▁block -12.9672 ▁0.211 -12.9674 ▁7.65-7.6 -12.9681 duct -12.9681 ▁litres -12.9686 ][1,8] -12.9686 ▁(46.5 -12.9686 -2.62 -12.9687 9.90 -12.9688 ▁114.9 -12.9692 aseous -12.9693 -4,1- -12.9693 13.5 -12.9695 ▁9.91 -12.9696 ▁0.261 -12.9704 -1-(1,3- -12.9709 ▁131.1 -12.9711 ▁74.5 -12.9711 ▁72.0 -12.9715 INTERMEDIATE -12.9717 ▁aminopropyl -12.972 ▁131.5 -12.9722 ▁ferric -12.9724 ▁cell -12.9724 TSA -12.9725 arom -12.9732 8.59 -12.9735 formamidine -12.9738 Tyr -12.9738 ▁73.3 -12.974 ▁(39.4 -12.9742 ▁0.358 -12.9743 ▁50.3 -12.9746 ▁(39.0 -12.9747 ▁10.38 -12.9748 ▁tBuOH -12.9749 ({5- -12.975 }-2,2 -12.975 Tetra -12.9753 ▁prisms -12.9754 ▁stainless -12.9754 ▁2,3,5- -12.9754 ▁69.2 -12.9755 {(4 -12.9755 ▁9.71 -12.9756 ▁(448 -12.9762 ▁pipe -12.9762 ▁succinate -12.9763 dimethylbutan -12.9764 ▁monoethyl -12.9769 -5-(1,1,2,2 -12.9773 ▁alkylation -12.9783 ▁(0.119 -12.9783 ▁stock -12.9785 ▁Amine -12.9787 =20:1 -12.9788 ▁(94% -12.9789 ▁AcCN -12.9791 dibromobutane -12.9792 ▁PBr -12.9793 composed -12.9793 isophthalate -12.9793 ▁3-((2- -12.9793 ▁7.64-7.5 -12.9794 ▁soda -12.9795 ▁effect -12.9795 ▁Reagent -12.9795 ▁2-{5- -12.9798 10:90 -12.9802 ₃): -12.9805 ▁supported -12.9805 [1,2,3] -12.9808 ▁68.4 -12.9811 Acetone -12.9811 partic -12.9816 ▁2,3,4,6- -12.9817 Cbz -12.9817 -1-[2-(4- -12.9817 ▁4.51-4. -12.9824 '-(3- -12.9825 propanediamine -12.9832 ▁132.3 -12.9833 diisopropoxy -12.9835 ▁66.3 -12.9837 methyloxiran -12.9837 ▁0.425 -12.9845 ▁preced -12.9848 ▁combiflash -12.9848 ▁60-70° -12.9848 xanth -12.985 ▁developed -12.985 ▁Addition -12.9852 ▁74.6 -12.9855 ▁100:1 -12.9856 -5-[4- -12.9864 ▁7.63-7.5 -12.9867 ▁(468 -12.9867 ▁(0.188 -12.9869 ▁(83% -12.9872 crotonate -12.9874 Å -12.9879 ▁began -12.9879 ▁deliver -12.9879 ▁kieselguhr -12.9879 ▁Time -12.988 [1-(2,4- -12.9885 ▁65.8 -12.9886 ▁(389 -12.989 ▁63.0 -12.9892 ▁7.14-7.2 -12.9892 ▁(437 -12.9894 ▁63.3 -12.9894 omo -12.9895 ]-2-[( -12.9896 ▁(36.8 -12.9897 ▁131.7 -12.9897 ▁cyclohexene -12.99 ▁ethoxymethylene -12.9902 ock -12.9902 ▁0.336 -12.9902 ▁(565 -12.9904 anis -12.9905 ▁acidify -12.9908 ier -12.991 ▁(71% -12.991 -2',4',6'- -12.9911 resorcinol -12.9911 ▁Result -12.9911 ▁longer -12.9911 ▁said -12.9911 ▁optically -12.9912 sulfanylidene -12.9912 (2-((2- -12.9914 nitroimidazole -12.9914 )-4-{[3,5- -12.9915 carbobenzyloxy -12.9917 ▁1.75-1.6 -12.9917 Asp -12.9918 -(3-(1- -12.992 =60 -12.9921 ▁chloroacetone -12.9923 ▁-25° -12.9926 ▁59.3 -12.9927 ▁132.5 -12.9929 =1/2 -12.9937 ▁bring -12.9939 DPPF -12.9943 ▁sealable -12.9943 ▁0.247 -12.9944 nonafluoro -12.9945 ,2,5,5 -12.9948 ▁SunFire -12.995 =17.1 -12.9951 ▁7.10-7.0 -12.9952 ▁(399 -12.9954 ▁styrene -12.9955 methoxyphenethyl -12.9955 +1% -12.9957 ▁7-[4-(2- -12.9961 ▁(36.2 -12.9965 {4-[2-(2- -12.9972 [3.3.0] -12.9974 ▁indicates -12.9974 ▁polarity -12.9975 ▁68.9 -12.9975 ▁1.95-2.0 -12.9977 =14.8 -12.9978 ▁63.5 -12.9979 )-(+)-2- -12.9979 8.71 -12.9983 ▁0.280 -12.9985 =9.09 -12.9987 -16- -12.9991 Trp -12.9992 oxiranylmethoxy -12.9993 8_ -12.9996 -(5-(1- -12.9996 ▁72.8 -12.9999 manufacture -13.0001 >99% -13.0001 ▁(6.45 -13.0003 8.98 -13.0004 ▁recover -13.0004 ▁125.8 -13.0005 ▁Silysia -13.0006 -5' -13.0012 -3-(2,2- -13.0015 ▁(31.9 -13.0017 ▁3-{2- -13.0017 ▁67.7 -13.002 ▁0.378 -13.0024 0.21 -13.0025 -6-[4- -13.0025 ▁anhydrate -13.0027 ▁5-95% -13.0027 (3-(3-( -13.0031 & -13.0032 ▁perchlori -13.0033 cycl -13.0034 ▁(36.7 -13.0036 ▁4-[(5- -13.0037 BBN -13.004 43.6 -13.0041 -4.05 -13.0042 5.50 -13.0044 ▁KHCO -13.0046 [5-(6- -13.0047 ▁Rh -13.0049 ▁(51.0 -13.005 ▁30×100 -13.0051 ▁7.26-7.1 -13.0051 =15.7 -13.0051 ▁(40.8 -13.0053 oxolan -13.0055 onate -13.0057 dodecano -13.0058 -6-(2-( -13.006 ▁(32.3 -13.0066 heptafluoro -13.0068 (1,3,4- -13.007 ▁50.9 -13.0071 ▁orthoacetate -13.0074 ▁(84% -13.0077 ▁quantitatively -13.0077 -8-[1-( -13.0079 Difluorophenyl -13.0079 ▁59.8 -13.0081 dodec -13.0081 cyclopropan -13.0084 ▁(476 -13.0085 butylstannyl -13.0088 ][1] -13.009 -4-(2,5- -13.009 ▁(0.245 -13.0091 -3-[4-(4- -13.0093 dispiro -13.0097 decomposition -13.0098 nitrite -13.0098 [7-(4- -13.0102 (0.5 -13.0103 ▁sulphide -13.0103 BrFN -13.0104 piperazino -13.0104 phosphite -13.0108 ▁99.5% -13.0109 ▁132.4 -13.0111 589 -13.0111 ▁propionitrile -13.0112 ▁carbazate -13.0114 ▁(42.5 -13.0118 ▁5-[3- -13.0119 pir -13.0121 ▁131.4 -13.0122 ▁(37.4 -13.0122 -6'- -13.0123 ▁(615 -13.0123 0:40 -13.0124 ▁phenylhydrazine -13.0125 ▁61.4 -13.0125 ▁blanket -13.0127 ▁65.6 -13.013 Isco -13.013 ▁optical -13.0134 mandelic -13.0134 peptide -13.0134 ▁68.2 -13.0136 ▁Methylmagnesium -13.0148 ▁64.4 -13.0148 ▁(65.0 -13.0149 ▁-40 -13.0149 ▁(369 -13.0151 5.35 -13.0152 ▁phosphor -13.0154 piperidinomethyl -13.0161 ▁7.43-7.5 -13.0166 pyruv -13.0166 enetetramine -13.0167 ▁cyclobutanone -13.0167 ▁(427 -13.0167 ▁mechanically -13.017 9.96 -13.0177 ▁(40.6 -13.0186 ▁72.7 -13.0188 =16.6 -13.0194 ▁121.8 -13.0195 Trimethylsilyl -13.0197 anthraquinone -13.0199 ▁terminate -13.0199 ▁azeotropically -13.0199 ▁10.26 -13.02 ▁needle -13.02 ▁7.69-7.6 -13.0201 ▁(73% -13.0203 ▁70.1 -13.021 bout -13.0215 tre -13.0221 ▁70.6 -13.0224 ▁(0.181 -13.0224 ▁Cyclohexane -13.0224 Sigma -13.0228 EDC -13.0229 ▁125.3 -13.0229 ▁7.68-7.6 -13.0231 ▁8-(3- -13.0232 ▁PCC -13.0232 ▁centrifuge -13.0232 octanoyl -13.0234 ▁(76% -13.0234 ▁(39.6 -13.0235 ▁0.296 -13.0244 ▁(4.94 -13.0244 {[1-(2- -13.0247 ger -13.0249 )+]: -13.0255 ▁0.396 -13.0255 ▁71.6 -13.0256 ▁0.210 -13.0259 glyoxyl -13.026 -115° -13.0262 -5-{[4-( -13.0263 dimethylbutanoyl -13.0264 8.88 -13.0264 ▁Scientific -13.0265 ▁55-60° -13.0265 ler -13.0266 androstane -13.0268 dichlorophenol -13.0276 ▁(35.3 -13.0278 ▁(49.5 -13.0278 ▁(4.66 -13.0279 ▁130.6 -13.0279 ▁135.4 -13.0286 ▁(0.198 -13.0287 -5-[1-( -13.029 ▁71.0 -13.0292 ′-(1- -13.0295 ▁decomposed -13.0296 {[4-(3- -13.0301 ▁57.3 -13.0303 ▁68° -13.0304 -2,3,4 -13.0305 ▁0.340 -13.0307 ▁0.326 -13.0308 agnetic -13.0312 (1-(3-( -13.0313 ▁(43.0 -13.0316 ▁71.8 -13.0317 hexaen -13.0321 Kieselgel -13.033 ▁thermocouple -13.033 ▁triplet -13.033 ▁uptake -13.033 propylammonium -13.0332 ▁133.8 -13.0332 bSR -13.0333 ▁7.31-7.4 -13.0336 ▁135.3 -13.0337 ▁10.14 -13.0338 ature -13.0342 Cpd -13.0345 benzothiazine -13.0349 ▁combine -13.0357 ▁70.2 -13.036 ▁4-((6- -13.036 hydroxybutan -13.0362 -4,9′- -13.0363 arge -13.0366 ▁67.0 -13.0374 0-95% -13.0377 {2-[(2- -13.0377 ▁10.36 -13.0381 ▁66.9 -13.0382 ▁glycerol -13.039 ▁(431 -13.0391 ▁0.327 -13.0393 dimethoxybenzoyl -13.0394 phthalonitrile -13.0396 ▁Titanium -13.0396 ▁(36.3 -13.0397 Azabenzotriazol -13.0399 ▁7.62-7.6 -13.04 ▁7.75-7.7 -13.04 -6-(3,4- -13.0402 ▁(489 -13.0403 ▁(446 -13.0405 -3-[1- -13.0406 ▁56.9 -13.0406 ▁4-[1-(4- -13.0413 )-1-((1 -13.0414 ▁CaCl -13.0415 9.95 -13.0416 -5,9- -13.0418 phosphin -13.0422 =8.78 -13.0423 [6-[ -13.0425 internal -13.0426 ethylsulfinamido -13.043 Carbamoyl -13.043 ▁-75° -13.043 6_ -13.0431 ▁phenylacetyl -13.0433 Trichloro -13.0433 mesyl -13.0434 ▁decomposition -13.0434 ▁(1×20 -13.0437 -4-((5- -13.0437 /10% -13.0437 ▁(5.85 -13.0437 ▁isopropenyl -13.0437 {3-[2-( -13.0437 =0% -13.0439 ,7,9,10- -13.0439 ▁132.6 -13.0441 ▁131.3 -13.045 rin -13.0451 ▁(4.69 -13.0452 XI -13.0454 -4-[(5- -13.0462 ▁continuous -13.0462 ▁Manganese -13.0463 -[2,2′ -13.0463 ▁(6.36 -13.0464 ▁63.8 -13.0465 ▁1.95-1.8 -13.0465 ▁7.07-7.1 -13.047 ▁(4.89 -13.047 -1.92 -13.0472 ▁(41.0 -13.0472 silyloxy -13.0475 ▁72.2 -13.0476 propyne -13.0479 ui -13.048 ▁PhCH -13.0486 ▁3-(1,4- -13.049 benzylalcohol -13.0491 charcoal -13.0493 )-2-[[(2 -13.0495 ▁full -13.0496 ▁Chromatograph -13.0496 ▁length -13.0496 ▁FDMS -13.0497 ▁67.6 -13.05 ▁(1:4 -13.05 silicon -13.0502 ▁(0.280 -13.0503 ▁66.8 -13.0505 ▁2.04-1.9 -13.0505 ▁7.11-7.0 -13.0506 (5-{3- -13.0508 -4-((3- -13.051 ▁123.6 -13.0511 +1]+= -13.0514 ▁(95/5 -13.0515 ▁0.369 -13.0516 ▁0.310 -13.0517 ▁(675 -13.052 *3) -13.0521 ▁123.9 -13.0521 ▁69.9 -13.0524 enantiomer -13.0527 pregn -13.053 ▁Celsius -13.053 ▁123.5 -13.0531 ▁70/30 -13.0532 ▁purifying -13.0534 ▁125.6 -13.0536 ▁ended -13.0537 [[1-( -13.0538 hexahydropyrido -13.0539 ▁(40.3 -13.054 -125° -13.0541 ▁(486 -13.0544 chlorid -13.0546 ▁glyoxyl -13.0546 ▁850 -13.0548 ▁(4.71 -13.055 7_ -13.0552 ▁(5.55 -13.0552 butenoate -13.0558 ▁charge -13.0558 ▁(5.18 -13.056 azatricyclo -13.056 tetraoxa -13.0562 ▁Dimethylamine -13.0563 ▁rotation -13.0564 =10% -13.0566 octene -13.0568 cinnamyl -13.0569 ′-[( -13.0569 ▁7.09-7.0 -13.0571 ▁(0.276 -13.0572 ▁(635 -13.0581 cycloocta -13.0582 3)3), -13.0584 {2-[2-(4- -13.0587 Dicyclohexyl -13.0591 reaction -13.0595 pentanedio -13.0595 [1,2,5] -13.0596 -4-[2-(2- -13.0597 ▁90.0 -13.0597 sextet -13.0597 13.0 -13.0597 -9,11- -13.0598 ▁20-30° -13.0598 ▁74.0 -13.0601 ▁131.0 -13.0605 ▁open -13.0606 ▁80.6 -13.0608 osin -13.0611 ▁5-[4-( -13.0611 ▁99.9% -13.0613 8.97 -13.0616 ▁(0.149 -13.0617 -3-[3-(4- -13.0619 ˜7. -13.062 ▁4-(2-(4- -13.0621 ][2,7] -13.0621 aminocrotonate -13.0622 sulphonate -13.0623 ▁5-[2-( -13.0624 pentadien -13.0626 ▁7.64-7.6 -13.0627 CHLOROFORM -13.0629 soluble -13.063 ▁melt -13.0631 collidine -13.0631 ▁ascorbate -13.0631 ▁thirty -13.0631 =90% -13.0639 ▁(63% -13.064 =2.20 -13.0643 ▁135.0 -13.0645 ▁produc -13.0646 ▁0.290 -13.0652 -5-((2- -13.0652 ▁(50.5 -13.0654 ▁(47.5 -13.0661 ▁TEMPO -13.0666 Phenoxy -13.0667 propenyloxy -13.0669 homopiperazine -13.0669 -4-((6- -13.067 ▁76.5 -13.067 tolyloxy -13.0674 ▁71.9 -13.0683 ▁(0.187 -13.0686 ▁(37.6 -13.0693 9.38 -13.0695 corresponding -13.0697 ▁(5.37 -13.0698 -1,2,6 -13.0699 butyrolactone -13.0699 ▁azobis -13.0699 ▁(5.48 -13.07 icosa -13.0701 -((7- -13.0703 -{3-[2- -13.0705 benzothiazin -13.0709 [3.2.2 -13.0713 Neat -13.0715 ▁(478 -13.0716 ▁cal -13.0717 20:80 -13.0718 ▁69.5 -13.0719 ▁62.7 -13.072 ▁(0.750 -13.0721 thiomorpholino -13.0724 ▁7.71-7.6 -13.0725 can -13.0729 {3-[(4- -13.0729 camphor -13.0732 ▁7-(( -13.0732 butyramido -13.0734 ▁Poly -13.0734 ▁stirbar -13.0734 )-5-((2-( -13.0734 ▁19×150 -13.0738 95.5 -13.0739 ▁134.1 -13.074 )-7-(3-( -13.074 ▁(4.81 -13.0745 [6-(5- -13.0747 ▁glucose -13.0754 butylsulfinyl -13.0754 ▁4-[4-(2- -13.0755 ▁132.0 -13.0755 ▁3-((3- -13.0759 ▁2/1) -13.0764 ▁Dried -13.0768 ▁perruthenate -13.0768 ▁methanethiolate -13.0768 ▁(45% -13.0768 ▁lot -13.0771 (3,4,5,6- -13.0773 (2,8- -13.0774 port -13.0774 =15.4 -13.0778 morpholinoethoxy -13.078 {[7- -13.0782 butylester -13.0788 )-2-(2,5- -13.0789 exchange -13.08 ▁Referenti -13.0803 2',4'- -13.0804 {2-[1-(2- -13.0806 ▁(576 -13.0806 ▁7.68-7.7 -13.0807 peroxy -13.0809 =1.77 -13.0809 7.50 -13.0811 -(4-{4- -13.0812 ▁62.9 -13.0814 =15.5 -13.0819 ▁(45.5 -13.082 ▁(72% -13.0821 }-2,5- -13.0823 -[9- -13.0824 ▁(500.0 -13.0825 dimethylpentan -13.0829 ▁(42.6 -13.0834 ▁3-(1,3- -13.0834 [5,4,0] -13.0837 >300° -13.0837 ▁hydrosulfite -13.0837 ▁isolation -13.0837 graphy -13.0838 =17.0 -13.084 -2,4,7 -13.0841 ▁72.1 -13.0844 =5:1 -13.0844 ▁hydrazone -13.0847 ▁7.15-7.0 -13.0849 ▁side -13.0851 semicarbazide -13.0853 ▁73.2 -13.0863 9.28 -13.0869 benziodoxol -13.0872 ▁biotage -13.0872 ▁hydroperoxide -13.0872 ▁golden -13.0872 ▁SEM -13.0872 heptanoyl -13.0872 benzoylchloride -13.0882 ▁7.05-7.0 -13.0883 ▁60.7 -13.0883 ▁(41.4 -13.0891 iodoethane -13.0895 ▁123.3 -13.0896 ▁overlapping -13.0897 ▁6-[4-( -13.0899 cholest -13.09 -55° -13.0902 -5-[2- -13.0902 ▁(66% -13.0903 AUC -13.0905 -3(1 -13.0905 phe -13.0906 ▁remainder -13.0907 nicotinamido -13.0907 ▁0.0007 -13.0907 )-6-(2,2,2 -13.0909 isonicotinoyl -13.0909 ink -13.0909 ▁(5.88 -13.0913 ▁7.72-7.6 -13.0915 ▁123.4 -13.0916 ▁133.9 -13.0917 ▁7.14-7.0 -13.0918 ▁(40.4 -13.0918 -6-[2-( -13.0919 ▁alkylated -13.0921 -2-(7-(4- -13.0923 Acetylamino -13.0923 morph -13.0929 ▁71.1 -13.0931 ▁(69% -13.0933 6-(2,2- -13.0934 found -13.094 ▁Resonance -13.0942 ▁oxidation -13.0942 3-[4-(7-{[2-( -13.0942 ▁7.69-7.7 -13.0946 ▁7.07-7.0 -13.0948 dibromobenzene -13.0949 0-35% -13.0951 -6,9- -13.0952 ▁4-[5-( -13.0958 phenethoxy -13.096 benzothien -13.0962 ▁131.9 -13.0966 ▁nBuLi -13.0969 ▁(0.310 -13.0969 ▁(497 -13.0971 ▁changed -13.0974 coloured -13.0975 ▁3-(2,3,4,6- -13.0975 ▁1.90-1.8 -13.0979 ▁70-80° -13.0979 piperdin -13.0979 -4,4'- -13.098 lactate -13.098 crystal -13.0982 -1,2,3,3 -13.0985 biphen -13.0985 isothiazolidin -13.0985 ▁73.7 -13.0988 iodobenzoyl -13.0989 ▁80.5 -13.0993 ▁(42.3 -13.0993 ected -13.0998 ▁67.4 -13.0999 ▁73.1 -13.1005 ▁sulphoni -13.1006 ▁7.54-7.6 -13.1008 ▁shift -13.1012 glycinamide -13.1013 =3:1 -13.1018 ▁(5.78 -13.1022 8.99 -13.1022 -135° -13.1024 2.5° -13.1028 ▁71.7 -13.1029 ribo -13.1033 ▁40:60 -13.1034 ▁(48.5 -13.1035 oxazoline -13.1038 ▁68.8 -13.104 thiocyanato -13.1043 solv -13.1043 ▁73.4 -13.1044 nickel -13.1046 sulphide -13.1046 ▁4-(2,5- -13.1046 ▁partial -13.1047 sulfonimidoyl -13.1047 ▁7.70-7.7 -13.1053 -[4′-( -13.1055 heated -13.1057 ▁4-(3-(4- -13.1063 ner -13.1066 ▁10-20% -13.1078 Chrom -13.1079 ▁71.2 -13.108 HOBt -13.1082 ▁3-(2,5- -13.1082 ▁common -13.1083 ▁pressurized -13.1083 ,6,10 -13.1083 tetraazatricyclo -13.1083 ▁experimental -13.1087 ▁Su -13.1089 ▁(37.7 -13.1091 ▁(6.85 -13.1093 ▁(41.3 -13.1096 ▁Hexa -13.1096 [3-[( -13.1098 ▁additionally -13.11 ▁4-(4,6- -13.1113 ▁63.4 -13.1113 ▁(5.86 -13.1114 ohydroximoyl -13.1118 diazene -13.1118 ▁hypo -13.1118 -4-[3-(4- -13.1123 diphenylsilane -13.1125 -[4-(2,6- -13.1128 pentanedione -13.1133 ▁(300.0 -13.1133 ▁4-[5-(4- -13.1134 tripyrrolidino -13.1135 XVI -13.1137 penicillan -13.1154 1,3,5,2,4,6 -13.1154 ▁good -13.1154 imidodicarbonate -13.1154 ▁electrospray -13.1164 ust -13.1166 -3-[1-( -13.1171 ▁racemate -13.1174 ▁(5.11 -13.1174 )-4-(6-( -13.1174 ▁Pyr -13.1175 {3-[5- -13.1176 ▁71.5 -13.1178 ▁Cbz -13.1179 ▁(38.8 -13.1179 ▁124.0 -13.1182 ▁10.21 -13.1189 Mercapto -13.119 ublication -13.119 ▁hydrolysed -13.119 cyclopentadienyl -13.119 sulfenyl -13.1191 rous -13.1192 ▁7.65-7.7 -13.1194 ▁phenylacetylene -13.1194 )-2-(2-(4- -13.12 -6-(2,6- -13.1203 position -13.1205 ▁4.56-4. -13.1205 hydrofuran -13.1206 ▁9.97 -13.121 azocin -13.1216 {5-[4-( -13.1218 Py -13.1225 ▁Subsequent -13.1225 distilled -13.1225 ▁1.70-1.8 -13.1228 ▁Isopropanol -13.1228 propion -13.1232 ▁2.05-2.1 -13.1232 -6-[(4- -13.1233 {2-[(5- -13.1234 ▁8-(1- -13.1239 ▁(477 -13.1241 ▁(496 -13.1242 =14.7 -13.1243 MgS -13.1255 mercaptan -13.1261 ▁resolved -13.1262 ▁6:4 -13.1262 /1,4- -13.1263 ▁cleanly -13.1264 ▁1.75-1.8 -13.1265 ▁7.76-7.7 -13.1265 ▁(35.8 -13.1266 TEA -13.1267 ▁1.90-2.0 -13.1267 ▁7-(5- -13.127 ▁Tin -13.1272 -3-[2-(4- -13.1274 pip -13.128 5.55 -13.1283 ▁74.4 -13.129 Methoxybenzyl -13.1291 )-5-((1 -13.1294 Fmoc -13.1298 complex -13.1298 -7-(3,5- -13.1298 Imidazol -13.1298 ▁pulverized -13.1298 ▁diazoacetate -13.1298 tetrazolo -13.13 [2,2- -13.1302 ▁74.3 -13.1303 -2-[4-(3- -13.1303 ▁135.5 -13.1307 ▁(91% -13.1308 -{2-[3- -13.1317 flo -13.1319 ▁7.47-7.3 -13.1319 ▁enantiomeric -13.132 -{3-[3- -13.1321 furaldehyde -13.1323 [2-(2,2,2- -13.1327 Zorbax -13.1335 ▁isotope -13.1335 benzimidamide -13.1335 cont -13.1336 -[3-(1 -13.1337 ▁AUC -13.1337 ▁5-((4- -13.1337 triazatricyclo -13.1337 -7-[1-( -13.1338 ▁Benzene -13.1347 Butyldimethylsil -13.1354 gram -13.1363 ▁123.1 -13.1364 methoxyanilino -13.1365 uch -13.137 evaporation -13.1371 ▁suck -13.1371 ▁attain -13.1371 ▁(74% -13.1372 -5,3′- -13.1372 ▁contain -13.1372 BrClN -13.1373 {[3-(4- -13.1375 ▁PTLC -13.1376 ▁1.65-1.7 -13.1377 [4-[4-( -13.1388 -{3-[4- -13.1388 APCl -13.139 ▁133.6 -13.1396 ▁7.67-7.6 -13.1398 ▁(39%) -13.1398 ▁136.8 -13.1404 ▁partition -13.1405 ▁(44.4 -13.1405 Wako -13.1408 barbituric -13.1408 guanine -13.1408 ▁thereinto -13.1408 ▁82° -13.141 dinitrophenyl -13.1413 ▁6.98-7.0 -13.1416 ▁172.7 -13.1418 ,4,5,9 -13.1421 ▁(44.3 -13.1423 cyclopentylamine -13.1424 ▁trifluor -13.1428 -5-(1,3- -13.143 (6,6- -13.1431 ▁79.6 -13.1435 -24- -13.1438 -7-[(4- -13.1439 uro -13.1439 ▁methyliodide -13.1441 fold -13.1443 oxopropanoyl -13.1444 ][1,3,5] -13.1444 Gemini -13.1445 azacyclododec -13.1445 ▁7/3 -13.1447 ▁68.7 -13.1448 dimethoxytrityl -13.145 ▁2.53-2.6 -13.1451 ▁7.06-7.1 -13.1453 oi -13.1459 ▁chlorodifluoro -13.1464 ▁123.2 -13.1464 ▁133.0 -13.1471 ▁(38.7 -13.1473 3,3,5- -13.1475 acrolein -13.1481 aziridine -13.1484 2,2,3- -13.1485 ▁2.10-2.0 -13.1487 8.87 -13.1487 ▁73.6 -13.1489 ▁2.03-1.9 -13.1489 ▁(81% -13.1491 8.81 -13.1497 ▁Py -13.1504 ▁78.0 -13.1512 3,4,8,9- -13.1518 valinamide -13.1518 Varian -13.1519 Pyrazol -13.1524 ▁7.02-6.9 -13.1525 ▁(29%) -13.1529 ▁1.65-1.5 -13.153 camphorsulfoni -13.1531 -3-[[ -13.1532 stat -13.1536 -[(7- -13.1541 ▁(41.6 -13.1541 lactam -13.1542 {[1-(3- -13.1543 ethanesulphonate -13.1545 ▁Analogix -13.1546 cinnolin -13.1551 ▁Racemic -13.1556 ▁absence -13.1556 ▁Bull -13.1556 activated -13.1556 peak -13.1556 ][1,2,5] -13.1558 ▁band -13.1558 ohydrazide -13.1558 ▁vinylmagnesium -13.1558 ▁fractionated -13.1559 ▁traces -13.1562 1,2,2,2- -13.1564 ▁(49.0 -13.1583 =14.6 -13.1588 ▁7.66-7.6 -13.1589 ▁73.0 -13.1591 =15.3 -13.1592 Volume -13.1593 ▁70-75° -13.1593 ▁Alternatively -13.1593 ▁OXONE -13.1593 ▁Suzuki -13.1593 deutero -13.1593 ▁7.42-7.5 -13.1593 ▁(60-120 -13.1593 ▁elevated -13.1593 ▁7.77-7.7 -13.1596 3,3,8,8 -13.1602 ▁134.0 -13.1606 ▁Isobutyl -13.1608 imidic -13.1611 ▁7.61-7.6 -13.1615 nipecot -13.1618 octadec -13.162 ▁125.1 -13.1622 ▁120.3 -13.1624 ▁132.8 -13.1627 ▁45-50° -13.163 -200° -13.1633 ▁40-60° -13.1635 ▁(67% -13.164 ▁Journal -13.164 9.87 -13.1643 Nitrobenzyl -13.1645 ▁30:1 -13.1648 phenoxyacetamido -13.1651 ▁5-(2,6- -13.1651 ▁10.11 -13.1658 ▁132.9 -13.1659 ▁65.2 -13.1666 ▁(47.0 -13.1666 [2,3 -13.1668 Personal -13.1668 Formula -13.1669 {2-[5- -13.1669 pentadeca -13.1673 ▁2.04-2.1 -13.1673 ▁INTERMEDIATE -13.1675 -5-[3-( -13.1676 {[5-(4- -13.1677 1/4 -13.1683 =1.76 -13.1684 =15.1 -13.1687 -6(1 -13.1688 ▁(39.7 -13.1696 ▁4-({ -13.1698 (((2- -13.1701 ▁rais -13.1704 ▁Material -13.1706 ▁DMPU -13.1706 ▁4′-[(4- -13.1707 ▁1.94-1.8 -13.1708 85:15 -13.1709 ▁Sili -13.171 ▁77.4 -13.1714 -[2-[4- -13.1714 -3-[4-(3- -13.1716 PCC -13.1716 silanyl -13.1718 ▁1.82-1.7 -13.1723 138° -13.1725 ▁(8:2 -13.1726 9.99 -13.1727 ▁137.3 -13.1734 ▁135.7 -13.1734 ▁92.5 -13.1739 -1,2′- -13.1739 ▁124.3 -13.174 glutamate -13.1742 ▁Pyridinium -13.1744 -[3,4′ -13.1744 cyclohexadiene -13.1744 sphere -13.1744 ▁backfill -13.1745 ▁3.35-3.4 -13.1747 ▁7.67-7.7 -13.1747 ▁7.74-7.7 -13.1748 ▁133.1 -13.175 ▁132.7 -13.1756 0.5° -13.1756 -190° -13.1762 ▁125.2 -13.1764 ▁Ethylene -13.1766 ▁2.00-1.9 -13.1767 ioxoimidazolidin -13.1771 ▁122.9 -13.1773 ost -13.1774 {3-[4-(4- -13.1779 ▁azodi -13.1781 ▁frozen -13.1782 acrylamido -13.1782 ▁greenish -13.1782 amo -13.1783 identified -13.1783 ▁effected -13.1783 ▁BEH -13.1786 ▁[6-( -13.1788 ▁7.06-7.0 -13.179 ▁0-80% -13.1791 ▁79.3 -13.1804 ▁(42.4 -13.1804 ▁122.0 -13.1809 ▁(62% -13.1809 ▁7.25-7.4 -13.1813 ▁conduct -13.1819 ▁spirit -13.182 ▁analytically -13.1822 ▁lowered -13.1824 treatment -13.1826 ▁65.9 -13.1832 ▁2.00-2.1 -13.1839 ▁we -13.184 PG -13.1844 11.3 -13.1845 ▁134.7 -13.1845 methanesulphon -13.1849 ▁136.0 -13.1856 graph -13.1858 ▁PPTS -13.1858 ▁wavelength -13.1858 Azetidin -13.1858 ▁30:70 -13.1859 ▁Molecular -13.1864 ▁(44.6 -13.1866 ,14,14 -13.1867 ▁CONH -13.1871 -[2-[[ -13.1881 9.97 -13.1886 ▁7.65-7.5 -13.189 ▁75.4 -13.1893 multiple -13.1896 ▁assigned -13.1896 ▁Xbridge -13.1897 -165° -13.1897 hexadecano -13.1898 ▁8:1 -13.19 ▁2.15-2.0 -13.1901 ▁74.2 -13.1906 ▁121.7 -13.1919 ▁4-(2-(5- -13.1924 ▁135.8 -13.1924 ka -13.1925 ▁7.73-7.6 -13.1928 though -13.1935 ▁(0-60% -13.1936 ▁4-[4-(3- -13.194 7.5° -13.1942 tetr -13.1942 ▁121.9 -13.1947 decanoate -13.196 ▁GCMS -13.196 ▁1.85-1.7 -13.1961 went -13.1968 ▁treat -13.1971 cytidine -13.1974 ▁every -13.1974 -1(18),2(6),4,1 -13.1974 ▁20-50% -13.1976 ▁70.7 -13.1977 tributyltin -13.198 [[(1,1- -13.198 ▁Jones -13.1983 ▁9,10- -13.2002 =100 -13.2005 thiazepine -13.2005 (7-(4- -13.2007 ▁76.8 -13.2009 ▁19*150 -13.2013 ▁destroy -13.2013 ▁Triethylsilane -13.2013 indacen -13.2013 ▁dihydrobromide -13.2014 hepten -13.2015 green -13.2015 ▁0.0025 -13.2017 ▁122.7 -13.2021 INO -13.2023 ▁higher -13.2026 -3.55 -13.2026 xy -13.2029 ▁(41.7 -13.2038 ▁(27%) -13.2039 diethylphosphono -13.2042 1.5° -13.205 ▁injected -13.2052 ▁propiolate -13.2052 ▁0.0008 -13.2052 ▁1.92-2.0 -13.2055 ▁3.42-3.3 -13.2055 ▁Δ -13.2058 ▁Conc -13.206 ▁122.8 -13.206 -1-((6- -13.2061 ▁7-[( -13.2065 ▁(2×60 -13.2065 ▁2.54-2.6 -13.2069 160 -13.208 ▁133.5 -13.2085 diisobutyl -13.2087 ▁1.80-1.6 -13.2099 ▁74.9 -13.2099 ▁(22%) -13.2105 ▁(40.9 -13.2115 ▁7.13-7.2 -13.2117 tirred -13.2122 ▁(39.8 -13.2125 ▁diiodomethane -13.213 methanimine -13.213 isobutyraldehyde -13.2131 formic -13.2131 )-2-((6- -13.2135 ▁7.48-7.3 -13.2135 ▁83.3 -13.2136 ▁135.9 -13.2143 ▁137.1 -13.2152 )−] -13.2156 ▁75.5 -13.2156 ▁138.2 -13.216 ▁123.0 -13.217 ▁bulk -13.217 ▁rubber -13.217 ▁hemihydrate -13.217 ▁bromopyruvate -13.217 {4-[2-(5- -13.2171 Celite -13.2173 ▁litre -13.2178 ▁TBSCl -13.2179 ▁134.8 -13.2179 ▁1.85-1.9 -13.2181 ▁7.13-7.0 -13.2183 -1,10- -13.2185 ▁93.6 -13.2187 ▁7.56-7.4 -13.2194 ▁anti -13.2195 13.3 -13.2195 [1-(3,5- -13.2197 oxepino -13.2202 ▁(49.7 -13.2208 ▁(3×60 -13.2208 (1,2,4,5- -13.2209 ▁Phosphor -13.2209 ▁remains -13.221 ▁twenty -13.221 =100/0 -13.221 ▁recovery -13.221 ▁continue -13.221 ▁USA -13.2213 ▁1.84-1.9 -13.2219 propylsulfanyl -13.2221 DME -13.2222 [2-(2,3- -13.2225 ki -13.2235 Toluenesulfonyl -13.2236 9.88 -13.2237 ▁TBS -13.2241 -7(4 -13.2242 vant -13.2242 succinami -13.2248 ▁Louis -13.2249 ▁2,3,5,6- -13.225 ▁ozone -13.225 ▁Distilled -13.225 Pyrrolo -13.225 ode -13.225 diastereomer -13.2253 temperature -13.2253 ▁7.71-7.7 -13.2256 ethanediamine -13.2262 (5-(6- -13.2267 95:5 -13.2269 ▁recrystalliz -13.2279 ▁121.5 -13.2281 nitroanisole -13.2289 ▁radiation -13.2289 ▁reductive -13.2289 oxybispropane -13.229 oxathiin -13.229 ▁(79% -13.229 ▁purge -13.2291 octanol -13.2295 TP -13.2295 propargylamine -13.2296 ▁including -13.2297 ▁7.08-7.0 -13.2298 imidazoline -13.2305 PHOS -13.2308 ▁4-[(6- -13.2314 8.5° -13.2322 wet -13.2322 1,1,3,3- -13.2326 cytosine -13.233 methylsilanolate -13.233 ▁Separation -13.233 cyclopentadiene -13.2332 ▁dibutyltin -13.2333 ▁page -13.2334 9.5° -13.2334 ▁3.65-3.7 -13.2335 9.89 -13.2336 ▁bromoethane -13.2336 ▁upper -13.2337 ▁1.86-1.9 -13.2337 [3-(3,5- -13.2344 9.41 -13.2344 ▁(45.7 -13.2349 ,9,10,10 -13.2349 ick -13.2353 [2,2,2- -13.2356 ▁124.5 -13.2358 9.58 -13.2368 ▁119.6 -13.2369 ▁80-85° -13.237 ▁Peak -13.237 ▁6-((( -13.2373 Calc -13.2374 ▁79.2 -13.2374 ▁separately -13.2375 ▁148.5 -13.2376 ▁1.55-1.6 -13.2377 2,3,9- -13.2389 {2-[3-( -13.2392 ▁134.5 -13.2394 ▁generally -13.2397 ▁136.5 -13.2403 ▁Sulf -13.2407 glyme -13.241 ä -13.241 ▁Filtrate -13.241 ▁blown -13.241 ▁caustic -13.241 ▁incorporated -13.241 select -13.2411 ▁1.92-1.8 -13.2412 ethanimidamide -13.2413 ▁1.96-1.8 -13.2414 ▁78.9 -13.2414 ▁7.80-7.7 -13.2416 Isopropoxy -13.2417 -{1-[4- -13.2418 ▁114.8 -13.2423 )-2-{( -13.2429 ▁distill -13.2443 ▁alkali -13.2444 (6-(4-( -13.245 ▁3.60-3.5 -13.245 ▁respect -13.2451 ▁Analogously -13.2451 -185° -13.2455 ▁7.78-7.7 -13.2455 ▁7.84-7.8 -13.2458 ▁6.99-7.0 -13.2458 *,6 -13.2479 8:1 -13.248 ▁138.0 -13.248 7-(4,4,5,5- -13.2485 BuONa -13.2492 oxepan -13.2492 butylmethylether -13.2493 -155° -13.2494 octahydropyrrolo -13.2495 pentanedioate -13.2496 ▁7.66-7.7 -13.2496 MTBE -13.2496 pentalene -13.2496 crystallization -13.2497 ▁1.74-1.6 -13.2497 ▁3.80-3.7 -13.2498 ▁trichloroacetyl -13.2503 ▁137.8 -13.2508 -21- -13.2509 Methylmorpholine -13.2514 ▁79.8 -13.252 ▁138.1 -13.2521 ▁137.7 -13.2524 ▁7.75-7.6 -13.2524 >98% -13.2524 150×4.6 -13.2526 Pos -13.2531 METHOD -13.2533 carbinol -13.2533 ▁composition -13.2533 ▁membrane -13.2533 picolinoyl -13.2533 cinnamaldehyde -13.2535 ▁decompose -13.2535 vacuum -13.2537 ▁(42.7 -13.2537 diazatetracyclo -13.2538 ▁3.40-3.3 -13.2538 [1,5] -13.254 thane -13.2541 ▁1.83-1.9 -13.2543 anti -13.2547 ▁118.8 -13.2552 ▁>9 -13.2564 ▁122.5 -13.2571 =17.3 -13.2571 ▁colour -13.2573 ▁divided -13.2574 1',2' -13.2574 ogen -13.2581 -1-[1-( -13.2582 aldoxime -13.2606 -6.85 -13.2615 sulfone -13.2615 rough -13.2615 ][4,1] -13.2616 ▁5/95 -13.2616 Bridge -13.2616 ▁Nucle -13.2619 -3,4'- -13.262 ▁72.9 -13.2621 ▁(9/1 -13.2623 ▁6.96-7.0 -13.2624 ▁134.9 -13.2627 picolin -13.2628 butenoic -13.2634 66.5 -13.2635 ▁73.9 -13.2643 ▁(26%) -13.2644 ▁extra -13.2644 ▁1.90-1.7 -13.265 8.3%). -13.2652 penam -13.2654 pentacosa -13.2657 ü -13.2657 ₅ -13.2657 ▁settling -13.2657 ▁sulphite -13.2657 ▁135.2 -13.2657 cyclopentanamine -13.2657 anisaldehyde -13.2657 ▁MHZ -13.266 Purity -13.2662 ▁7.00-6.9 -13.2665 ▁2.10-2.2 -13.2665 ▁DIC -13.2673 ▁137.5 -13.2674 ▁133.7 -13.268 benzen -13.268 Note -13.2682 ▁77.5 -13.269 ▁134.4 -13.2691 iodobutane -13.2695 XXXI -13.2695 [1,6- -13.2697 ▁7.53-7.6 -13.2698 carboaldehyde -13.2699 -2,2,4,4- -13.2699 ▁TsCl -13.2699 ▁dihydropyran -13.2701 ered -13.2703 ▁2.35-2.4 -13.2705 ▁3.15-3.0 -13.2706 ▁7.85-7.8 -13.2706 -3,10 -13.2708 ▁79.9 -13.2711 ▁RuCl -13.2714 ▁99.9 -13.2722 =0.1% -13.2729 isothiazolo -13.2734 ▁135.1 -13.2736 -4,7,10,13,16,19 -13.274 ▁milky -13.274 ▁spatula -13.274 ▁cyanohydrin -13.274 diazocine -13.2743 ▁3.52-3.4 -13.2745 ▁alkyl -13.2745 ▁3.20-3.1 -13.2746 ▁7.78-7.8 -13.2747 ▁(40.7 -13.2749 ▁buffered -13.2753 ▁probe -13.2754 ydro -13.2757 Trifluoromethoxy -13.276 -2-[(1- -13.276 4.5° -13.2764 ▁Similar -13.2782 [6.4.0.0 -13.2782 ▁1.80-1.7 -13.2783 ▁78.8 -13.2783 nitril -13.2783 jk -13.2784 ▁1.98-1.8 -13.2786 ▁136.9 -13.279 ▁Chromatographic -13.2793 ▁Chromatorex -13.2794 4,4,5,5,5- -13.2794 (5-((( -13.2822 ▁7.10-7.2 -13.2823 ▁85/15 -13.2825 ▁assumed -13.2825 Pack -13.2825 -3,4,7,1 -13.2825 Alfa -13.2825 oni -13.2828 tetramethyliso -13.2829 ▁7.86-7.8 -13.2829 ▁3.50-3.4 -13.283 half -13.283 butanediol -13.2831 ▁6.95-7.0 -13.2834 ▁2.10-1.9 -13.2836 -55% -13.2854 ▁134.6 -13.2857 ▁134.2 -13.2858 ▁3.75-3.6 -13.2864 purchased -13.2867 ▁Yellow -13.2867 ▁amination -13.2867 Acros -13.2868 ▁freezer -13.2869 ▁1.74-1.8 -13.287 ▁1.63-1.7 -13.2871 epoxypropane -13.2872 ▁2.03-2.1 -13.2872 oxathiazolidine -13.2872 piper -13.2873 ux -13.2874 ▁7.90-7.8 -13.2874 ▁7.28-7.4 -13.2875 ▁124.8 -13.2879 ▁137.4 -13.2884 -8-[( -13.2895 (6-(5- -13.2897 ▁3.70-3.6 -13.2899 Pak -13.2899 isocyan -13.2902 ▁experiment -13.2905 ▁sequential -13.2909 stilbene -13.291 (1,3,5- -13.291 naphthonitrile -13.291 ▁ABX -13.291 hexyn -13.2914 [1-(2,6- -13.2914 ▁7.72-7.7 -13.2917 ▁7.03-6.9 -13.2917 ▁137.6 -13.2929 [4-(2,2,2- -13.2932 ▁1.87-1.7 -13.2936 ▁4-{( -13.2939 [5-(2,4- -13.2942 {5-[3-( -13.2943 {5-[2-( -13.295 Acryloyl -13.2952 ≈ -13.2952 cymene -13.2952 (2,3,5,6- -13.2952 ▁7.41-7.5 -13.2953 ▁Was -13.2954 succinamide -13.2955 ▁1.72-1.8 -13.2955 ▁148.4 -13.2956 ▁Cooling -13.2962 stall -13.2967 ▁133.4 -13.2971 ▁90:10:1 -13.2975 pentanal -13.2976 6.5° -13.2978 6,18- -13.2982 ▁93.4 -13.2983 trifluoroacetoxy -13.2984 hexadec -13.2985 {1-[5- -13.299 ▁136.1 -13.2995 ▁metaperiodate -13.2995 ▁necessary -13.2995 ▁patent -13.2995 ▁proportion -13.2995 ▁74.8 -13.2996 normal -13.3002 ▁pumped -13.3002 ▁96:4 -13.3003 ▁2.20-2.1 -13.3006 ▁2.02-1.9 -13.3007 -6,10- -13.3008 [5,6] -13.3008 ▁4-[5-(3,5- -13.3016 [3-(3,4- -13.3017 androsta -13.3017 ▁120.1 -13.3027 ▁double -13.3028 89.5 -13.303 ▁sulfolane -13.3038 threo -13.3038 )-[1( -13.3041 ▁3.68-3.7 -13.3044 pinacol -13.3045 Description -13.3045 ▁121.6 -13.3045 hydroxide -13.3047 -3,4,6- -13.3049 hloroperbenzoic -13.3051 ▁75.3 -13.3056 ▁tetraoxide -13.306 ▁120.2 -13.306 ▁Un -13.3069 -5,6,6 -13.307 glycin -13.3075 [4-(1,1- -13.3076 ▁seal -13.308 uan -13.3082 sarcosine -13.3082 benzothiepine -13.3082 ▁Detect -13.3082 ▁77.0 -13.3082 ▁(+/-) -13.3083 ▁142.2 -13.3087 ▁7.81-7.7 -13.3088 tetrakis -13.3088 Scheme -13.3088 ▁0-70% -13.309 ▁135.6 -13.31 -[[1-[ -13.3107 -3-((3- -13.3109 -6-((( -13.311 cycloheptane -13.3116 Prop -13.3118 -5,10- -13.3119 -7-(5- -13.3123 ▁combining -13.3125 ▁generation -13.3125 ▁heavy -13.3125 ▁Phosphorous -13.3125 ▁3.51-3.4 -13.3129 ethenesulfonyl -13.313 ▁˜7 -13.3131 ▁7.92-7.8 -13.3132 isation -13.3133 -2-(9- -13.3138 ▁{2-[3- -13.3138 drying -13.314 dimethylcarbamo -13.3142 ▁124.2 -13.3156 ▁115.1 -13.3158 para -13.3163 ▁138.3 -13.3167 octacos -13.3169 ▁decreasing -13.3169 ▁head -13.3169 hexachloroethane -13.3171 ▁6.90-6.9 -13.3175 ▁3.30-3.2 -13.3176 calculated -13.3176 butyr -13.3176 ▁1.88-1.7 -13.3177 ▁3.85-3.7 -13.3177 ▁7.83-7.8 -13.3178 ▁85.7 -13.3179 ▁2.06-1.9 -13.3179 ISN -13.3182 ▁124.4 -13.3193 ince -13.3196 methanesulfinate -13.3197 pentanamido -13.3199 ▁change -13.32 ▁134.3 -13.3202 [1,8] -13.3204 ▁High -13.3205 pentalen -13.3208 ▁boil -13.3211 ▁strong -13.3212 Acquity -13.3213 ▁Reverse -13.3213 ▁Temperature -13.3213 ▁91.6 -13.3213 ▁15-20° -13.3213 ▁PhMe -13.3215 ▁2.11-2.0 -13.3216 ▁7.73-7.7 -13.3219 ▁115.6 -13.3223 ▁124.6 -13.3225 ▁136.3 -13.3237 (2-(2,5- -13.3238 5,6,7,8,9,10- -13.3238 ▁3.62-3.5 -13.3256 trihydrofluoride -13.3257 ▁elemental -13.3257 diphosphetane -13.3257 ▁thioanisole -13.3257 tech -13.3261 ▁7.88-7.8 -13.3263 ▁cation -13.3264 Trimethoxy -13.3268 ▁137.0 -13.3269 -{4-[3-(4- -13.3271 ▁136.6 -13.3275 ▁7.74-7.6 -13.3277 ▁atom -13.3285 ▁115.5 -13.3292 ▁124.9 -13.3292 ▁79.7 -13.3298 2,4,4- -13.3299 ▁does -13.3301 ▁substrate -13.3301 cause -13.3301 ▁precatalyst -13.3301 -2,3,5- -13.3301 ▁1.86-1.7 -13.3302 ▁aftertreatment -13.3303 enamido -13.3304 ▁40/60 -13.3305 (1-(3,5- -13.3305 ▁85.6 -13.3306 ▁119.5 -13.3306 ▁6.88-6.9 -13.3306 ▁1.72-1.6 -13.3307 interm -13.331 =14.9 -13.3314 sulfam -13.3316 ▁115.4 -13.3316 ▁1.83-1.7 -13.332 ▁119.8 -13.3328 prost -13.3337 ▁DIPE -13.3344 3′,4′,5′,6′- -13.3345 ▁Appl -13.3345 Strem -13.3347 3,20- -13.3348 ▁hydrogensulfite -13.3348 ▁NaOCl -13.335 ▁75.7 -13.3353 ▁3.75-3.8 -13.3354 cyanophosphonate -13.3362 omycin -13.3372 ▁82.6 -13.3375 CBZ -13.3375 ▁115.8 -13.3377 ▁7.50-7.6 -13.3382 ▁fil -13.3383 boron -13.3389 (2-((4- -13.339 malonami -13.339 ▁quartet -13.339 ▁Reflux -13.339 ik -13.339 )-(+)-1- -13.339 ▁container -13.3391 ▁1.98-2.0 -13.3393 ▁PCT -13.3394 ▁1.97-2.0 -13.3394 mult -13.3394 ▁monochloride -13.3394 ▁7.79-7.7 -13.3395 ▁75.6 -13.3396 ▁78.6 -13.3397 ▁Heating -13.3398 now -13.3399 ▁1.68-1.5 -13.3401 ▁76.2 -13.3408 ▁7.28-7.1 -13.3411 -(10- -13.3423 CHIRALPAK -13.3435 histidine -13.3435 after -13.3441 benzisothiazol -13.3443 ¹ -13.3443 under -13.3443 ▁(3×80 -13.345 ▁82.5 -13.3451 ▁136.2 -13.3453 10,12- -13.3455 ▁3.71-3.6 -13.3467 hydrazinocarbon -13.3472 -1,4'- -13.3474 ▁7.39-7.2 -13.3479 ▁gravity -13.348 ▁Hünig -13.348 4′,3′- -13.348 61.9 -13.3481 phene -13.3481 ▁2.12-2.0 -13.3484 ▁2.01-2.1 -13.3486 ▁7.86-7.9 -13.3486 ▁2.15-2.2 -13.3487 =50/1 -13.3488 ▁1.60-1.5 -13.3492 (4-(2,4- -13.3492 ▁presente -13.3493 ▁Fraction -13.3493 77.5 -13.3494 ▁7.12-7.2 -13.3503 ▁80.8 -13.3505 -(4-{ -13.3522 ! -13.3525 epimino -13.3525 alaninamide -13.3525 arginine -13.3525 tryptamine -13.3525 ▁maximum -13.3525 ▁chromatogra -13.3527 ▁1.73-1.8 -13.3528 ▁3.91-3.8 -13.353 ▁1.76-1.6 -13.3531 ▁2.65-2.5 -13.3532 titanium -13.3534 reverse -13.3534 ▁2.25-2.3 -13.3534 ▁0.0016 -13.3534 ▁119.7 -13.3543 {4-[4-(2- -13.3547 ▁hydriodi -13.3547 ray -13.3547 -[[6- -13.355 bora -13.3561 lized -13.3561 15:85 -13.3567 iridium -13.3571 ▁Letters -13.3571 ▁station -13.3571 PrMgCl -13.3571 ▁adapt -13.3571 ▁aminoguanidine -13.3572 hexahydroazepino -13.3573 ▁inside -13.3575 90.5 -13.3575 ▁2.14-2.0 -13.3575 DMT -13.3576 ▁7.89-7.9 -13.3576 Combi -13.3579 ruthenium -13.3579 ▁chang -13.3588 ▁120.4 -13.3588 ▁3.45-3.5 -13.3593 propanethiol -13.3593 ▁3.72-3.6 -13.3607 (2,3,5- -13.3616 ▁Triton -13.3617 ▁3.41-3.3 -13.362 piperid -13.3621 ▁6.99-6.9 -13.3622 ▁Chloroacetyl -13.3623 DBU -13.3625 ▁2.07-1.9 -13.3625 ▁7.03-7.0 -13.3631 fluro -13.3648 ▁effervescence -13.3662 ▁seven -13.3662 ▁subsided -13.3662 Butanol -13.3662 0±5° -13.3662 ▁3,4,5,6- -13.3662 =1:0 -13.3664 ▁3.34-3.4 -13.3666 =1:5 -13.3668 ▁3.45-3.3 -13.3668 ▁1.56-1.6 -13.3668 ▁reduc -13.3669 Cyclobutyl -13.367 ▁7.82-7.8 -13.3671 carbimido -13.3674 3.5° -13.3677 [7-(5-{3- -13.3681 ▁137.9 -13.3685 ▁122.6 -13.3689 norleucin -13.3692 {4-[(5- -13.3699 ethen -13.3702 acridin -13.3704 bismuth -13.3708 ▁olefin -13.3708 ▁greater -13.3708 ▁eight -13.3709 ▁136.4 -13.371 ▁PPA -13.371 -9,9- -13.3715 -3,4,4 -13.3721 benzhydrylidene -13.3721 5′,6′ -13.3727 ▁7.15-7.3 -13.3727 ▁7.52-7.6 -13.3729 ▁deposit -13.3734 ▁7.41-7.2 -13.3742 ▁start -13.3752 ▁Silver -13.3754 ▁mantle -13.3754 Benzhydryl -13.3755 ▁1.61-1.7 -13.3758 ▁2.13-2.0 -13.3759 ▁7.77-7.8 -13.376 ▁7.82-7.7 -13.3761 [5,6- -13.3762 ▁7.04-6.9 -13.3765 -((1-(4- -13.3769 formaldehyde -13.3784 ▁˜10 -13.3787 phthalate -13.379 2,2,4,6,7- -13.3798 ▁137.2 -13.3799 ▁136.7 -13.38 ▁analog -13.38 ▁PTFE -13.3801 ▁tRET -13.3801 ▁65-70° -13.3801 ▁77.8 -13.3805 ▁7.83-7.7 -13.3808 naphthamide -13.3809 ▁1.78-1.6 -13.3809 ▁1.87-1.9 -13.3811 particle -13.3811 ▁1.70-1.5 -13.3812 sulfuric -13.3814 ▁140.1 -13.3826 -5,7( -13.3835 ▁120.7 -13.3843 ▁119.9 -13.3844 ▁Chloride -13.3848 ▁decantation -13.3848 ▁equimolar -13.3848 ▁seeded -13.3848 >250° -13.3848 3-(1,1,2,2- -13.3848 ▁opened -13.3849 ▁1.76-1.8 -13.3852 ▁3.36-3.4 -13.3852 ▁6.97-6.9 -13.3854 ▁3.25-3.1 -13.3854 ▁3.10-3.0 -13.3855 [2′-( -13.3861 ami -13.3867 ▁synthesised -13.3869 ▁140.2 -13.3875 [2,5- -13.3881 oxalate -13.3881 bromoisobutyrate -13.3895 porphyrin -13.3895 ▁Application -13.3895 ▁6.98-6.9 -13.3901 ▁7.91-7.8 -13.3901 ▁7.75-7.8 -13.3903 ▁(2×80 -13.3904 ▁2.85-2.7 -13.3904 ▁1.62-1.5 -13.3905 pure -13.391 )-1-((4- -13.3911 ▁77.6 -13.3922 -4-(5-(1- -13.3923 127° -13.3923 pyri -13.3933 ▁rang -13.3936 =100/1 -13.394 Acetamido -13.3942 carbobenzoxy -13.3942 ▁75-80° -13.3944 ▁dimethylsulfate -13.3947 ▁1.77-1.6 -13.3948 ▁1.58-1.6 -13.3949 ▁115.7 -13.3952 −80° -13.3953 ▁1.45-1.5 -13.3958 66.4 -13.3962 due -13.3967 ▁(˜50 -13.3969 lambda -13.3989 ▁Colorless -13.3989 ▁controlled -13.3989 ▁crashed -13.3989 ▁sonication -13.3989 shape -13.3989 ollected -13.3989 trifluro -13.399 OSu -13.3992 ▁3.55-3.6 -13.3995 ▁2.06-2.1 -13.3996 flavone -13.3997 ▁111.5 -13.3998 dicyclohexylurea -13.4008 ▁20/80 -13.4013 2,4,5,6- -13.4018 -(−)- -13.4023 ▁1.67-1.7 -13.4036 ▁cotton -13.4037 ▁either -13.4037 ▁initiate -13.4037 ▁(0-15% -13.4037 [2-[4-( -13.4038 ▁117.6 -13.4038 ▁chromato -13.4038 ▁(99:1 -13.4043 ▁3.55-3.4 -13.4044 ▁3.82-3.7 -13.4044 ▁7.95-7.9 -13.4045 ▁7.85-7.9 -13.4045 ▁2.65-2.7 -13.4045 atch -13.4048 cyclic -13.405 ▁7.02-7.0 -13.405 ▁7.04-7.1 -13.4051 -7,10- -13.4052 ▁milliliter -13.4053 ▁seen -13.4055 Propanol -13.4058 ▁7.30-7.1 -13.406 isch -13.4062 ▁Allow -13.4081 naphthoquinone -13.4085 ▁application -13.4085 [3,4] -13.4085 rimethylboroxine -13.4085 -1,4,5,6,7,8- -13.4087 benzisothiazole -13.409 ▁6.85-6.9 -13.4091 ▁1.88-1.9 -13.4095 ▁118.7 -13.4097 98.6 -13.4097 ▁1.84-1.7 -13.4104 [13] -13.4104 ▁118.5 -13.4117 minor -13.4132 (1-((5- -13.4132 assume -13.4133 ▁copious -13.4133 ▁heptahydrate -13.4133 ▁immerse -13.4133 ▁resealable -13.4133 terephthalate -13.4134 [4-[3-( -13.4136 phenanthridine -13.4137 ▁7.01-6.9 -13.414 ▁2.08-1.9 -13.4143 ▁7.05-6.9 -13.4143 teen -13.4143 ▁show -13.4146 FCC -13.4147 ▁1.40-1.5 -13.4149 dioxabicyclo -13.4152 octadecyloxy -13.4152 -98° -13.4153 -{[(6- -13.4168 ▁[2-(5- -13.4171 ▁disp -13.4178 ▁139.5 -13.418 bridge -13.4181 ▁accomplish -13.4181 characterization -13.4181 ▁Commercially -13.4181 ▁modification -13.4181 ▁refined -13.4181 ▁20°-25° -13.4181 bipyrazinyl -13.4181 ▁TBAB -13.4182 ▁1.94-2.0 -13.4183 ▁chlorophosphate -13.4184 =17.5 -13.4184 ▁60/40 -13.4185 phosphanyl -13.4187 ▁2.85-2.9 -13.4188 Gilson -13.4193 ▁7.01-7.0 -13.4193 glycerol -13.4194 =16.7 -13.4201 Triazol -13.421 perfluoropropan -13.421 early -13.4212 dimethylsulfide -13.4212 ▁3.57-3.6 -13.4219 5.5° -13.4219 {4-[3-(2- -13.4221 ,8′ -13.4226 -3,1′- -13.423 ▁Vacuum -13.423 ▁atropisomer -13.423 ▁1.93-1.8 -13.4232 ▁Japan -13.4232 ▁2.62-2.5 -13.4235 ▁1.73-1.6 -13.4236 binaphthalene -13.4242 quat -13.4252 ▁3.4-3. -13.4253 propargyloxy -13.4265 {[(3,4- -13.4267 ▁99/1 -13.4274 ▁3.63-3.5 -13.4277 ▁Final -13.4278 Pyridyl -13.4278 alternative -13.4278 ▁undissolved -13.4279 hexadecahydro -13.4279 ▁99.8% -13.428 -2,3'- -13.428 ▁partitioning -13.4281 ▁2.92-2.8 -13.4283 ▁2.64-2.5 -13.4285 ℓ₃ -13.4291 ▁76.7 -13.4294 ▁118.9 -13.4294 ▁7.27-7.1 -13.4297 epi -13.4313 -{5-[2- -13.4316 ▁7.19-7.3 -13.4322 ▁combi -13.4327 ▁Horizon -13.4327 ▁Hyflo -13.4328 ▁1.97-1.8 -13.4332 ▁2.34-2.4 -13.4332 ▁1.78-1.8 -13.4333 ▁2.63-2.5 -13.4334 ▁3.60-3.7 -13.4336 [20] -13.4337 ▁1.81-1.9 -13.4338 Indole -13.4338 protection -13.434 ▁EX -13.434 hexadecan -13.4341 ▁reacted -13.4344 3,3,4,4,4- -13.4377 glucopyranose -13.4377 ² -13.4377 ▁Both -13.4377 ▁modified -13.4377 ▁caused -13.4377 {2-[4-(3- -13.4377 ▁Chim -13.4379 ▁Working -13.438 ▁Over -13.438 ▁1.96-2.0 -13.4381 -2,5,8 -13.4381 ▁3.22-3.1 -13.4382 ▁7.89-7.8 -13.4383 ▁2.22-2.1 -13.4384 estr -13.4387 ▁close -13.4387 ▁1.67-1.5 -13.4388 catalyst -13.4389 CombiFlash -13.4389 ethanoate -13.439 ▁temper -13.4393 isourea -13.4411 ▁118.4 -13.4417 [14.7.2.0 -13.4426 1,3,4,9- -13.4426 18,24] -13.4426 carrier -13.4426 carboximidate -13.4426 ▁prepacked -13.4427 ▁rpm -13.4427 ▁hydrous -13.4427 ▁Presen -13.4428 ▁transfer -13.4429 ▁1.99-2.0 -13.443 2,4,6,7- -13.4432 ▁2.12-2.2 -13.4432 thiolate -13.4433 ▁Selectfluor -13.4436 copper -13.4439 )-(−)-2- -13.4452 =16.9 -13.4459 {5-[(2- -13.4468 -8,3'- -13.4476 ▁purging -13.4476 vanillin -13.4476 propionamido -13.4476 ▁desiccator -13.4476 ▁([{3 -13.4476 ▁wax -13.4476 ▁99.6% -13.4478 ▁Wis -13.4479 cyclobutene -13.4482 ▁6.95-6.9 -13.4486 ▁CMA -13.4488 0.4% -13.4488 purged -13.4489 ×3.0 -13.4492 sym -13.4493 ▁7.50-7.3 -13.4496 ▁Hydr -13.4497 =95% -13.4509 esired -13.4519 ▁suspend -13.4525 ▁epoxide -13.4526 ▁hygroscopic -13.4526 ▁solubilize -13.4526 →50% -13.4526 -147° -13.4527 ▁3.31-3.2 -13.4531 ▁milli -13.4531 ▁3.92-3.8 -13.4533 {4′-[( -13.4535 ▁98.5% -13.4536 ▁TMSCN -13.4538 Analogix -13.4539 overlapping -13.4539 racemic -13.4539 [2,7] -13.4541 (3-((4- -13.4541 ▁1.62-1.7 -13.4551 ▁3.58-3.6 -13.4554 =90:10 -13.4554 ▁3.48-3.5 -13.4559 -4′-(3- -13.4561 sulphin -13.4567 ▁7.49-7.3 -13.4569 º -13.4576 flouro -13.4576 ▁(1,1′- -13.4576 ,2′-[1,3] -13.4578 ▁1.71-1.8 -13.4579 ▁HCHO -13.458 ▁3.28-3.3 -13.4581 ▁7.63-7.7 -13.4581 ▁2.60-2.5 -13.4581 ▁2.50-2.4 -13.4581 ▁7.81-7.8 -13.4584 (2,3,6- -13.4608 99.9% -13.4616 ▁(˜20 -13.4619 oxazepan -13.4623 ▁centrifugation -13.4627 ▁filtercake -13.4627 (1,2,3- -13.4627 ▁1.91-1.8 -13.4629 ▁2.09-2.0 -13.4631 ▁2.16-2.0 -13.4632 ▁7.87-7.8 -13.4632 ▁7.79-7.8 -13.4633 ▁2.95-2.8 -13.4633 ▁3.78-3.8 -13.4633 ▁118.2 -13.4638 ▁118.6 -13.4646 (2,7- -13.4658 flow -13.4661 xime -13.4663 aking -13.4667 ▁3.46-3.5 -13.4673 -1(8),2(6),9,11 -13.4677 Lancaster -13.4677 ▁covered -13.4677 ▁instrument -13.4677 ▁protective -13.4677 ▁solidifies -13.4677 ▁Each -13.4677 ▁collection -13.4678 Kanto -13.4678 ▁1.81-1.7 -13.4682 ▁2.87-2.9 -13.4683 -3-(3'- -13.4683 [3,3- -13.4686 pack -13.4686 ▁oxal -13.4687 starting -13.4692 ▁3.50-3.6 -13.4693 octenyl -13.4697 ▁7.66-7.5 -13.4707 trifluor -13.471 ▁6.92-6.8 -13.4712 [1,1′ -13.4713 Allyloxy -13.4728 diazenyl -13.4728 ▁COMU -13.4728 ▁Triphosgene -13.4728 ▁possible -13.4728 ▁Temp -13.4728 MASS -13.473 ▁99.7% -13.4731 =16.3 -13.4732 3,4,7,8- -13.4737 ▁1.63-1.5 -13.4738 ▁auto -13.474 ▁115.9 -13.474 boiling -13.4743 ▁3.00-2.9 -13.4743 vir -13.4749 Vinyl -13.4751 Oxa -13.477 OpenLynx -13.478 carbonothioyl -13.478 ▁2.56-2.6 -13.4782 ▁3.37-3.4 -13.4784 ▁1.93-2.0 -13.4784 ▁take -13.4785 ▁2.75-2.8 -13.4786 ▁2.08-2.1 -13.4786 ▁7.76-7.8 -13.4787 ▁2.45-2.3 -13.4787 ▁1.42-1.5 -13.4796 elut -13.48 {5-[(4- -13.48 ▁4.13-4.0 -13.4804 -4,10- -13.4808 octadecano -13.4821 phthaloyl -13.4831 [1,14] -13.4831 caprolactam -13.4831 ▁Furthermore -13.4831 ▁Invention -13.4831 ▁Standard -13.4831 ▁faint -13.4831 ▁thioglycolate -13.4831 ▁vaccuo -13.4831 94.9% -13.4832 -5,16- -13.4832 ELSD -13.4832 ▁Xphos -13.4833 ▁3.08-3.1 -13.4837 ▁3.67-3.7 -13.4837 ▁3.02-2.9 -13.4838 ▁2.32-2.2 -13.4838 ▁3.12-3.0 -13.4838 ▁3.93-3.8 -13.4838 ▁2,3,6- -13.4839 ▁2.00-1.8 -13.4841 sulpho -13.4842 {4-[2-(3- -13.4843 ▁1.55-1.4 -13.4844 ▁increase -13.4844 DIPEA -13.4846 -{3-[1-(4- -13.4878 -[2-[2- -13.4878 ▁Hydrochloride -13.4883 ▁induce -13.4883 ▁manipulation -13.4883 ▁Charge -13.4883 acenaphthylene -13.4883 ▁recrystaliz -13.4883 ▁Formaldehyde -13.4883 (4-((5- -13.4884 ▁0.0009 -13.4884 ▁indicat -13.4888 ▁2.90-2.8 -13.4888 ▁3.66-3.7 -13.4888 ▁1.70-1.6 -13.4892 =100% -13.4892 -[(4′- -13.4892 ▁138.5 -13.4894 ▁1.64-1.5 -13.4894 PREPARATION -13.4898 positive -13.4898 ▁7.16-7.0 -13.4901 tereoisomer -13.4935 MALDI -13.4935 ▁exclusion -13.4935 ▁stood -13.4935 morphinan -13.4935 ▁Bond -13.4935 triethoxysilane -13.4936 ▁(0-25% -13.4936 90:9:1 -13.4937 ▁exception -13.4939 ▁6.96-6.9 -13.4941 ▁2.18-2.2 -13.4941 ▁3.85-3.9 -13.4943 -82° -13.4949 -[4-(7- -13.4949 tertiary -13.4951 exothermic -13.4951 5-75% -13.4952 ▁3.65-3.5 -13.4962 {6-[2-( -13.4964 ▁4.10-4.0 -13.4971 :1→1:1) -13.4977 flav -13.498 [4-(1,3- -13.4981 anthranilate -13.4988 ▁Florisil -13.4988 ▁3.53-3.6 -13.4988 ▁Warm -13.4988 ▁will -13.4989 1,1,4- -13.499 ▁1.68-1.7 -13.4991 ▁6,11- -13.4991 ▁1.77-1.8 -13.4992 ▁3.70-3.7 -13.4995 ▁6.94-6.9 -13.4996 ▁2.25-2.1 -13.5001 system -13.5003 63.9 -13.5006 ▁1.35-1.2 -13.501 lution -13.5016 ▁2.75-2.6 -13.5022 ,11′ -13.5026 -98% -13.503 ▁99.4% -13.504 crystallized -13.504 thietan -13.504 protecting -13.504 threonine -13.504 ▁beaker -13.504 ▁wurde -13.504 ▁Gold -13.5041 -9,12- -13.5041 XIII -13.5041 ▁CrO -13.5042 ▁2.70-2.8 -13.5046 ▁1.71-1.6 -13.5047 dioxidothio -13.5049 ▁2.01-1.9 -13.505 IDE -13.5063 ▁Total -13.5068 anthracen -13.5089 2,3,4,5,6- -13.5092 ▁successive -13.5092 ▁basis -13.5093 biotin -13.5093 ▁MeLi -13.5093 ▁30/70 -13.5094 ▁repurified -13.5094 ▁3.74-3.6 -13.5097 ▁3.43-3.3 -13.5098 ▁1.54-1.6 -13.5101 ▁7.84-7.7 -13.5101 ▁1.45-1.3 -13.5108 ▁1.30-1.2 -13.5109 chemical -13.511 ,4,9,9 -13.511 ▁degree -13.5114 (6-(2,6- -13.5127 ▁6.50-6. -13.513 iqu -13.5133 phenanthridin -13.5142 [1′,2′:4,5] -13.5146 ▁ytterbium -13.5146 ▁evolved -13.5146 ▁molybdenum -13.5146 ▁mesitylene -13.5146 ▁pipette -13.5146 ▁35-40° -13.5146 valinate -13.5146 ▁1.91-2.0 -13.5151 ▁3.15-3.2 -13.5154 ▁7.94-7.9 -13.5155 ▁7.90-7.9 -13.5155 -2′,3′- -13.5155 ▁4.25-4.1 -13.5156 hydrox -13.516 -108° -13.516 ▁1.20-1.3 -13.5164 ▁3.68-3.6 -13.5173 cyclohept -13.5178 {1-[(4- -13.5183 benzoquinon -13.5195 minoacetaldehyde -13.5197 ▁3.61-3.5 -13.5199 ▁Aniline -13.52 pivalamido -13.52 dithiane -13.52 ▁Workup -13.52 {[1,6- -13.5204 ▁3.39-3.3 -13.5204 ▁6.86-6.9 -13.5205 ▁3.81-3.7 -13.5206 ▁2.82-2.7 -13.5208 -102° -13.521 -2,3(1 -13.5211 disiloxane -13.5226 hydrin -13.5227 isoleucine -13.5238 ▁2.58-2.6 -13.524 -4-(4-(4-( -13.5242 CBS -13.5244 -{1-[2- -13.5249 1,4,7,10- -13.5253 thymidine -13.5254 ▁COMPOUND -13.5254 ▁oxidized -13.5254 23,25- -13.5254 ▁85-90° -13.5254 disila -13.5258 ▁4.08-4.1 -13.5261 ▁2.34-2.2 -13.5261 ▁1.57-1.6 -13.5261 -[4-[4- -13.5278 ▁3.73-3.6 -13.5285 (2-((5- -13.5286 carbolin -13.5303 Shimadzu -13.5308 prolinate -13.5308 ▁Meldrum -13.5308 ▁Milwaukee -13.5308 ▁nucleoside -13.5308 ▁sultone -13.5308 [6,7] -13.5308 ▁ensure -13.5308 -168° -13.5308 ▁2.14-2.2 -13.5314 ▁6.91-6.9 -13.5315 ▁3.88-3.9 -13.5315 ▁4.15-4.0 -13.5316 ▁3.70-3.8 -13.5318 ▁1.56-1.4 -13.532 ▁azeotrope -13.5323 colorless -13.5325 ▁112.7 -13.5349 ▁3.64-3.5 -13.5351 ▁running -13.5362 ▁tungstate -13.5362 Blocks -13.5362 -114° -13.5367 ▁6.87-6.9 -13.5368 ▁1.79-1.6 -13.5369 ▁7.92-7.9 -13.5373 hydrobromide -13.5377 {2-[3-(2- -13.5387 ▁1.89-1.7 -13.5394 -4-(((1 -13.5403 thioxanthen -13.5405 oxi -13.5406 {2-[5-(4- -13.5413 )-1-(2,2 -13.5416 FLASH -13.5417 ≦ -13.5417 euter -13.5417 -132° -13.5418 ▁2.08-2.0 -13.5421 ▁3.38-3.4 -13.5422 ▁3.07-3.1 -13.5422 ▁2.17-2.0 -13.5423 ▁8.00-7.9 -13.5426 argon -13.5435 NMP -13.5445 ▁1.66-1.7 -13.5447 ▁rest -13.545 triaconta -13.5471 [4.3.0] -13.5472 prolinol -13.5472 ▁Powder -13.5472 ▁granular -13.5472 caproic -13.5472 ▁majority -13.5472 -156° -13.5474 hexenoate -13.5475 pentenoate -13.5476 (7-(3- -13.5481 ▁7.85-7.7 -13.5481 ▁2.80-2.7 -13.5481 ▁6.94-7.0 -13.5481 ▁2.20-2.0 -13.5482 analytical -13.549 (3-(2,6- -13.5492 overlap -13.5495 single -13.5501 =19:1 -13.5502 ▁6.91-6.8 -13.5504 [2-(2,5- -13.5504 toluen -13.5504 ▁7.57-7.4 -13.5515 {3-[3-( -13.552 °-100° -13.5522 ▁Approximately -13.5527 ▁isonipecotate -13.5527 ▁settle -13.5527 ▁fluvastatin -13.5527 ▁30-35° -13.5528 )-3-[4-(3,4- -13.5528 dibenzylidine -13.5528 ▁PEG -13.5529 ▁1.79-1.8 -13.5531 ▁3.12-3.2 -13.5533 ▁2.18-2.0 -13.5533 ▁7.87-7.9 -13.5534 ▁EtAc -13.5538 ▁2.40-2.3 -13.5538 >95% -13.5546 ▁1.25-1.3 -13.5551 ▁3.76-3.6 -13.5551 {4-[5-(2- -13.5554 ▁3.56-3.6 -13.556 ▁4.11-4.0 -13.5562 {[3,5- -13.5574 -(6-(6- -13.5578 ▁synthesiz -13.5581 ▁Auto -13.5582 ▁Amberlite -13.5582 ▁Corporation -13.5582 ▁fluid -13.5582 ▁3-[8-(2,6- -13.5582 ▁3.30-3.3 -13.5588 ▁3.56-3.4 -13.5589 ▁2.13-2.2 -13.5591 ▁2.95-3.0 -13.5592 oxonan -13.5598 Propane -13.56 BOP -13.5601 SIL -13.5612 ▁3.50-3.5 -13.5621 androstan -13.5637 alaninol -13.5638 ¼ -13.5638 ▁COMBIFLASH -13.5638 ▁BnBr -13.5638 ▁40-63 -13.5639 cyclopentadecin -13.5639 ▁2.70-2.6 -13.5642 ▁3.47-3.5 -13.5643 ▁2.61-2.5 -13.5644 ▁2.36-2.4 -13.5645 ▁3.94-3.8 -13.5646 ▁2.83-2.9 -13.5646 ▁1.52-1.6 -13.5646 ▁3.90-3.8 -13.5648 ▁1.89-1.9 -13.565 {[3-(2- -13.5657 ν -13.5658 ▁2.72-2.6 -13.5659 active -13.5678 propenal -13.5694 Hypersil -13.5694 Oakwood -13.5694 guanosine -13.5694 ▁Catalyst -13.5694 ▁Point -13.5694 electro -13.5694 ▁Amberlyst -13.5694 4',4',5,5,5',5'- -13.5694 [6.4.0.02,6] -13.5694 ▁bubbler -13.5695 ▁freebase -13.5695 ▁methoxyacetyl -13.57 ▁7.64-7.7 -13.57 ▁3.44-3.3 -13.57 ▁3.16-3.2 -13.5701 ▁2.84-2.9 -13.5701 ▁2.80-2.9 -13.5704 ′,13′ -13.5707 aromatic -13.5714 formula -13.5714 ▁3.42-3.5 -13.5726 ▁6.90-6.8 -13.5732 -{4-[4-(3- -13.574 -2,3,4,5,6,7 -13.5745 ▁elu -13.5747 -11,28- -13.5751 ▁ordinary -13.5751 hydroaluminate -13.5751 series -13.5751 ▁Dichlorobis -13.5751 ▁diketene -13.5752 ,6,7,8 -13.5753 ▁nitroethane -13.5753 ▁2.38-2.4 -13.5757 ▁6.89-6.9 -13.5757 ▁3.24-3.1 -13.5757 ▁2.42-2.3 -13.5759 ▁2.26-2.1 -13.576 ▁1.99-1.9 -13.5764 =7:3 -13.5768 ▁DMP -13.5788 ▁occur -13.5808 Crown -13.5808 ▁malonyl -13.5808 -13,19,21, -13.5808 ▁correct -13.5808 (4-(2-(2- -13.5811 ▁3.21-3.1 -13.5813 ▁3.73-3.8 -13.5814 ▁7.27-7.4 -13.5816 ▁3.25-3.3 -13.5816 ▁2.82-2.9 -13.5816 excess -13.5828 treated -13.5828 ▁ferr -13.5832 hydroquinone -13.5836 -1,22′ -13.5865 ▁TBAI -13.5865 ▁vented -13.5865 ▁Suspend -13.5865 ▁split -13.5865 5,6,8,9- -13.5865 ▁Super -13.5865 Proline -13.5867 ▁3.69-3.7 -13.5871 ,7,11- -13.5872 ▁2.00-2.0 -13.5875 ▁2.30-2.2 -13.5875 Tetrahedron -13.5885 ▁3.59-3.5 -13.5922 -2,3,10,16 -13.5922 ʹ -13.5922 pyrrolizin -13.5922 triggered -13.5922 ▁International -13.5922 ▁include -13.5922 [3′,2′:4,5] -13.5922 Quinolin -13.5922 ▁Acta -13.5922 ▁2.94-2.8 -13.5927 ▁2.32-2.4 -13.5927 galacto -13.5927 ▁4.02-3.9 -13.5928 ▁2.16-2.2 -13.5929 ▁2.11-2.2 -13.593 ▁3.05-2.9 -13.5931 ▁1.53-1.6 -13.5932 ▁4.20-4.1 -13.5932 ▁Trifl -13.5934 ▁resu -13.5936 ionized -13.5941 :2:1) -13.5948 [3-(2,4- -13.5951 {2-[6- -13.5958 ▁3.69-3.6 -13.5966 ferrocen -13.5971 ▁tautomer -13.598 oxazaborolidine -13.598 ▁drained -13.598 →10% -13.5981 ▁Some -13.5983 ▁7.99-7.9 -13.5987 ▁3.35-3.2 -13.5987 ▁4.05-3.9 -13.5988 ▁3.95-3.8 -13.5989 ▁2.22-2.3 -13.599 ▁3.10-3.2 -13.599 ▁6.92-6.9 -13.599 ▁specific -13.5992 ▁1.52-1.4 -13.5993 ▁eva -13.6001 ▁1.75-1.9 -13.6004 imethylhydantoin -13.6005 {1-[2-(4- -13.6008 ▁7.76-7.6 -13.601 ▁7.58-7.4 -13.6016 40:60 -13.6018 0.900 -13.6022 -[6-(6- -13.6034 Cyclohex -13.6038 ▁fifteen -13.6038 ▁milligrams -13.6038 ▁MeONa -13.6038 ▁Proton -13.6038 5±5° -13.6038 ▁dram -13.6039 ▁3.29-3.2 -13.6044 ▁2.55-2.4 -13.6046 ▁[4-(1 -13.6054 ▁1.78-1.9 -13.6056 ▁3,3′- -13.6069 4-[(6,7- -13.6075 {3-[(3- -13.6077 →1:1 -13.6079 orpholinopropoxy -13.6083 ▁3.52-3.6 -13.6092 electivity -13.6097 equilibrat -13.6097 boroxin -13.6097 ▁trimethylborate -13.6098 trihydroborate -13.6099 ▁1.55-1.7 -13.6099 ▁2-[(2′- -13.6101 ▁7,7- -13.6101 ▁2.72-2.8 -13.6101 ▁3.19-3.1 -13.6102 ▁3.62-3.7 -13.6103 ▁3.06-3.1 -13.6103 [2-(2,2- -13.6103 ▁3.28-3.2 -13.6103 ▁3.77-3.8 -13.6103 ▁3.78-3.7 -13.6104 [2-(2′- -13.6105 deoxyuridine -13.6107 ▁1.90-1.9 -13.6109 ˜100% -13.611 ▁1.46-1.5 -13.6116 supported -13.6119 ▁1.40-1.2 -13.6121 ▁variation -13.6124 halo -13.6132 crotoni -13.6135 -[2-[3- -13.6146 ▁3.44-3.5 -13.6153 riphenylphospine -13.6156 ▁Benzaldehyde -13.6156 ▁Industry -13.6156 ▁bisulphite -13.6156 ▁cumene -13.6156 -7,3'- -13.6156 ▁monobasic -13.6156 ▁2.30-2.4 -13.6161 ▁2.96-2.8 -13.6161 11,13- -13.6163 ▁3.83-3.7 -13.6163 ▁3.13-3.0 -13.6164 trated -13.6164 ▁7.93-7.9 -13.6167 ount -13.6168 -[1-[2- -13.617 {[4-(5- -13.6171 FIG -13.6178 Prepare -13.6178 ▁7.11-7.2 -13.6179 chloranil -13.618 ▁3.95-4.0 -13.6183 ▁Flashmaster -13.6215 ▁decolorized -13.6215 ▁oxybromide -13.6215 -2,3,4,6- -13.6215 ▁synthesizer -13.6215 ▁strongly -13.6216 -146° -13.6216 ▁apply -13.6216 -1,2,3,5,6,7 -13.6218 ▁2.26-2.3 -13.6221 ▁3.84-3.9 -13.6222 ▁6.93-6.9 -13.6226 ▁2.35-2.2 -13.6226 HOBT -13.6237 {[5-(2- -13.6243 hydroborate -13.6268 (2′,4′- -13.6272 [8,16, -13.6274 azanediyl -13.6274 ▁alkalized -13.6274 ▁hplc -13.6274 ▁naturally -13.6274 ▁primar -13.6274 ▁vaccum -13.6274 ▁       -13.6274 ▁Ester -13.6274 ▁benzine -13.6274 ▁3.52-3.5 -13.6276 ▁excessive -13.6278 ▁1.68-1.8 -13.6278 ▁3.29-3.3 -13.6279 ▁3.18-3.2 -13.6281 ▁3.54-3.4 -13.6281 ▁2.23-2.3 -13.6281 ▁7.20-7.4 -13.6281 3/7) -13.6281 -3,5( -13.6282 ▁3.05-3.1 -13.6283 ▁3.30-3.4 -13.6283 ▁1.50-1.4 -13.6303 thiazinan -13.6304 ▁7.42-7.2 -13.6304 ▁super -13.631 Thiophen -13.6322 =17.7 -13.6325 ▁3.54-3.6 -13.6328 [6,1- -13.6334 drawn -13.6334 ▁Aesar -13.6334 ▁Switzerland -13.6334 ▁cyclization -13.6334 ▁weakly -13.6334 ▁25-35° -13.6334 malonamide -13.6334 ▁proceeded -13.6338 -(5-(3,5- -13.6339 ▁3.53-3.4 -13.634 ▁7.97-7.9 -13.634 ▁3.20-3.2 -13.6341 ▁2.86-2.9 -13.6342 ▁7.93-7.8 -13.6344 ▁2.20-2.3 -13.6346 ▁1.58-1.4 -13.6347 ▁2.60-2.7 -13.6348 {[6-(4- -13.6349 isonipecoti -13.6353 ▁achieve -13.6355 mass -13.6362 ▁1.79-1.7 -13.6364 ▁1.58-1.7 -13.6388 ▁detect -13.6392 Burgess -13.6394 Propargyl -13.6394 ▁cleavage -13.6394 ▁microliters -13.6394 ▁property -13.6394 Argonaut -13.6394 3-[4-(7-[2-( -13.6395 ▁drive -13.6395   -13.6395 tetraazol -13.6396 -133° -13.6397 ▁interest -13.6398 ▁3.33-3.4 -13.6399 ▁3.79-3.7 -13.6401 ▁3.04-2.9 -13.6401 ▁2.07-2.1 -13.6401 ▁2.66-2.5 -13.6401 ▁3.23-3.1 -13.6401 ▁3.11-3.0 -13.6401 ▁3.76-3.8 -13.6402 ▁3.84-3.7 -13.6403 [2-[2-( -13.6403 ▁7.91-7.9 -13.6403 Hexahydro -13.6404 isophthali -13.6407 oxamate -13.641 sulfite -13.6415 DIEA -13.6418 erythro -13.6419 phor -13.642 ▁characteristic -13.6423 lysis -13.6425 ▁1.59-1.7 -13.6431 hose -13.6442 =1/4 -13.6444 thiopseudourea -13.6455 ▁uniform -13.6455 ▁Phenol -13.6456 ▁1.80-1.8 -13.6462 ▁7.98-7.9 -13.6462 ▁3.80-3.8 -13.6463 ▁2.21-2.1 -13.6464 ▁2.68-2.7 -13.6464 )-2-(4-(4,4 -13.6464 ▁3.80-3.9 -13.6467 ▁4.00-3.9 -13.6468 ▁1.66-1.5 -13.6469 ▁1.70-1.7 -13.647 ▁3.77-3.6 -13.6488 {6-[4-( -13.6511 ▁convert -13.6515 ▁0.00007 -13.6516 ▁halide -13.6516 ▁Carbonate -13.6519 ▁1.65-1.8 -13.652 ▁(97:3 -13.6521 4-(4,4,4- -13.6521 ▁7.62-7.7 -13.6522 pyroglutam -13.6523 ▁2.47-2.5 -13.6523 ▁8.06-8.0 -13.6523 ▁2.24-2.3 -13.6524 ▁4.07-4.1 -13.6524 lkylation -13.6524 ▁1.69-1.6 -13.6524 ▁2.2-2. -13.6525 ▁8.01-7.9 -13.6525 Naphthalen -13.6531 :5:1 -13.6533 ▁1.35-1.4 -13.6534 Combiflash -13.6541 Tolyl -13.6542 [4-(2,5- -13.6546 -2,5,5,8 -13.6576 ▁6.9-7. -13.6577 -[3,3′ -13.6577 \ -13.6577 pseudo -13.6577 ▁enzyme -13.6577 caution -13.6577 ▁ethanethioate -13.6577 ▁Similarly -13.6578 ▁99.0% -13.6578 ▁mild -13.6578 ▁LiBr -13.6579 -134° -13.6579 ▁3.89-3.9 -13.6585 ▁3.90-3.9 -13.6585 =1:9 -13.6586 ▁2.23-2.1 -13.6586 ▁2.45-2.5 -13.6587 ▁4.05-4.1 -13.6588 trideuterio -13.6589 ▁7.03-7.1 -13.6591 ▁1.79-1.9 -13.6591 ▁1.42-1.3 -13.6593 ▁1.60-1.4 -13.6595 ▁7.26-7.4 -13.6596 ▁tetrafluorobor -13.6602 ethanaminium -13.6609 ▁2.74-2.6 -13.6611 ▁Propion -13.6635 ▁Buchs -13.6639 ▁Perkin -13.6639 ▁PyBroP -13.6639 ▁embodiment -13.6639 ▁triturating -13.6639 ′(1′ -13.6639 -139° -13.664 -5,12- -13.6641 -179° -13.6641 toluic -13.6643 ▁2.91-2.8 -13.6644 ▁4.01-3.9 -13.6645 ▁2.99-2.9 -13.6645 ▁7.98-8.0 -13.6647 ▁2.88-2.9 -13.6647 ▁2.43-2.3 -13.6648 ▁3.07-2.9 -13.6648 ▁croton -13.6648 ▁1.61-1.5 -13.6652 phosphorylazide -13.6656 ▁3.00-3.1 -13.6658 ▁2.59-2.6 -13.6675 ▁3.58-3.5 -13.6678 ▁2-(7-(4-( -13.6694 azatetracyclo -13.6694 ,7,9,12 -13.6695 [22.3.1.04,9 -13.6701 register -13.6701 methylsulphenyl -13.6701 ▁25:75 -13.6701 trimethyloxonium -13.6701 50×21.2 -13.6702 ▁ethyleneglycol -13.6702 ▁98.9% -13.6704 ▁3.49-3.4 -13.6705 ▁3.27-3.3 -13.6706 ▁3.24-3.3 -13.6707 ▁2.79-2.7 -13.6709 :4:1 -13.671 ▁1.98-2.1 -13.6711 ▁2.30-2.1 -13.6716 mineral -13.6719 (4-{1- -13.6722 reference -13.6727 content -13.6727 ▁3.49-3.5 -13.6732 ▁7.29-7.1 -13.6732 ▁4.12-4.0 -13.6732 )-(+)-3- -13.6736 anisoyl -13.6739 -{3-[1- -13.6748 -1,2,9, -13.6751 glucose -13.6756 ,4,5,6,7,8- -13.6762 *6*- -13.6764 sulphamoyl -13.6764 chalcone -13.6764 termination -13.6764 ▁Layers -13.6764 Piperazin -13.6764 ▁polyethylene -13.6764 -141° -13.6764 2,4,8- -13.6765 -163° -13.6765 ▁97/3 -13.6768 Naphth -13.6769 ▁7.96-7.9 -13.6772 ▁3.03-3.1 -13.6773 ▁couple -13.6787 epichlorohydrin -13.679 -(1-(3-(3- -13.6797 =1/3 -13.6801 made -13.6811 ̸ -13.6827 ▁dehydration -13.6827 mittel -13.6827 ▁90-100° -13.6827 ▁AgNO -13.6827 ▁>90% -13.6827 ifying -13.6828 ▁2.93-2.8 -13.6832 ▁3.39-3.4 -13.6832 ▁2.97-2.8 -13.6833 ▁2.81-2.7 -13.6835 ▁2.40-2.5 -13.6835 XXVI -13.6837 ▁1.41-1.5 -13.6844 ▁3.5-3. -13.6848 [5-(2,6- -13.6851 (1-{[2-( -13.6871 thenoyl -13.6872 ,7,8,9,10,1 -13.688 ▁morning -13.689 ▁saponified -13.689 ≡ -13.689 -143° -13.6891 ▁3.26-3.3 -13.6896 ▁7.99-8.0 -13.6896 ▁2.37-2.4 -13.6897 ▁2.98-3.0 -13.6898 ▁7.97-8.0 -13.6898 ▁2.17-2.2 -13.6899 ▁2.67-2.5 -13.6899 ▁2.44-2.3 -13.6899 ▁4.22-4.1 -13.6899 ▁2.84-2.7 -13.6899 ▁2.64-2.7 -13.6899 ynoyl -13.69 ▁7.51-7.6 -13.6906 ▁1.47-1.5 -13.691 ▁6.84-6.8 -13.691     -13.6917 oxalami -13.6923 ▁3.43-3.5 -13.6948 hysical -13.6952 napthalen -13.6953 [3.3.1.13,7] -13.6953 ▁centrifugal -13.6953 ▁dripped -13.6953 ▁epimer -13.6953 ▁substitution -13.6953 ▁PBS -13.6954 ▁90-95° -13.6954 -2,3,6,7,8,9 -13.6954 -194° -13.6954 ▁(0-70% -13.6955 2,3,4,7- -13.696 ▁3.32-3.2 -13.696 ▁3.27-3.1 -13.6961 ▁8.02-7.9 -13.6964 -(1,6- -13.697 ▁1.46-1.3 -13.6971 ▁1.48-1.5 -13.6973 [2-(1,1- -13.6979 neutral -13.6981 chromatographed -13.6981 liquid -13.6981 -7,8,8 -13.6983 {3,4- -13.6984 ▁2.73-2.6 -13.7001 ▁directe -13.7005 oxetine -13.7018 ▁aspirator -13.7018 ▁incubated -13.7018 ▁methoxylamine -13.7018 ▁situ -13.7018 ▁Proceed -13.7018 ▁just -13.7018 ▁thiosalicylate -13.7018 -161° -13.7018 benzimidate -13.7018 ▁99.3% -13.7019 ▁0-2% -13.7019 ▁1.89-1.8 -13.7019 ▁2.76-2.6 -13.702 ▁2.59-2.5 -13.7023 ▁2.58-2.5 -13.7023 ▁2.76-2.8 -13.7024 ▁4′-({4-[ -13.7029 ory -13.7032 drop -13.7033 ▁7.39-7.5 -13.7036 ▁1.43-1.5 -13.7037 ▁7.00-7.1 -13.7041 ▁box -13.7046 glyoxal -13.7046 napht -13.7054 (4-(2-(5- -13.7058 (4-{[4- -13.7075 [4′,3′: -13.7082 spherical -13.7082 ▁Crystals -13.7082 ▁Technologies -13.7082 ▁exhaustive -13.7082 borabicyclo -13.7083 ▁perborate -13.7083 ▁fully -13.7083 ▁1.88-1.8 -13.7085 ▁2.77-2.8 -13.7087 ▁3.38-3.3 -13.7088 ▁3.60-3.6 -13.7088 ▁2.33-2.2 -13.7089 ▁3.17-3.0 -13.7089 ▁2.96-3.0 -13.709 ▁3.87-3.9 -13.7092 ▁3.40-3.5 -13.7094 ▁2.90-3.0 -13.7095 -{3-[1-(3- -13.7105 Isolute -13.711 XIX -13.7114 (4,7- -13.712 ▁1.92-1.7 -13.7124 ▁6.89-6.8 -13.7125 {3-[2-(4- -13.7134 iethylethanamine -13.7137 ▁7.35-7.5 -13.7144 ▁load -13.7144 ▁Crystallisation -13.7147 [1,3′] -13.7147 ▁3.09-3.1 -13.7153 ▁1.89-2.0 -13.7153 ▁3.63-3.7 -13.7153 ▁3.46-3.3 -13.7154 ▁7.60-7.7 -13.7154 ▁1.51-1.6 -13.7156 ▁7.94-7.8 -13.7157 ▁8.50-8. -13.7158 ▁8.03-8.0 -13.7159 ▁7.2-7.4 -13.7161 ▁1.23-1.3 -13.7162 ▁1.32-1.2 -13.7168 SCX -13.7176 ▁3.99-4.0 -13.7178 ▁gradual -13.7212 ▁stiffing -13.7212 =95/5 -13.7212 -121° -13.7214 -129° -13.7214 ▁2.49-2.4 -13.7215 azeto -13.7216 ▁2.33-2.4 -13.7218 ▁4.03-3.9 -13.7218 ▁2.98-2.8 -13.7219 ▁hyflo -13.7219 ▁3.89-3.8 -13.722 ▁3.14-3.0 -13.722 ▁2.66-2.7 -13.7222 ▁3.57-3.5 -13.7225 ethanimidate -13.7225 ▁1.69-1.5 -13.7226 ▁1.48-1.6 -13.7227 ▁1.34-1.4 -13.7227 ▁3.59-3.6 -13.7227 ▁1.22-1.3 -13.7228 ▁1.30-1.4 -13.7233 ▁7.18-7.0 -13.724 Cyclohexane -13.7242 high -13.7242 ▁3.56-3.5 -13.725 ▁6.88-6.8 -13.7251 ▁6.82-6.8 -13.7255 (6-((( -13.7272 [6.2.1.02,7] -13.7278 ▁contact -13.7278 ▁Dowtherm -13.7278 walled -13.7278 glutamine -13.7278 -164° -13.7279 ▁oxazolone -13.728 ▁purif -13.728 ▁4′-[(2- -13.7281 -159° -13.7281 ▁2.78-2.8 -13.7285 ▁1.88-2.0 -13.7285 ▁3.40-3.4 -13.7286 ▁3.88-3.8 -13.7287 ▁3.03-2.9 -13.7287 ▁3.18-3.0 -13.7288 ▁1.60-1.6 -13.7291 ▁7.02-7.1 -13.7294 ▁4.00-4.1 -13.7298 racemate -13.7308 produced -13.7308 powder -13.7308 ,4,5,6 -13.7311 ▁3.98-4.0 -13.7314 ▁3.51-3.5 -13.7319 dehyde -13.7321 Grad -13.7325 eterocyclic -13.7331 [2,2,2] -13.7344 ▁254/220 -13.7344 ▁Partition -13.7344 ▁earlier -13.7344 ▁quantities -13.7344 ▁solubility -13.7344 ▁glove -13.7344 ▁0-8% -13.7345 ▁3.33-3.2 -13.7351 ▁2.89-2.9 -13.7353 -205° -13.7354 ▁3.86-3.9 -13.7354 ▁2.36-2.2 -13.7354 ▁1.53-1.4 -13.7356 malei -13.7361 -{3-[5-(2- -13.737 atmosphere -13.7374 ▁3.67-3.6 -13.7378 -[4'- -13.7409 ]-1'(2' -13.7411 Apollo -13.7411 ▁detail -13.7411 oxybisethane -13.7411 -193° -13.7412 aerated -13.7414 ▁2.19-2.0 -13.7417 ▁3.22-3.3 -13.7418 ▁2.46-2.3 -13.742 ▁7.95-8.0 -13.7422 ▁2.90-2.7 -13.7425 ▁2.09-1.9 -13.7426 until -13.7441 ▁1.50-1.3 -13.7442 ▁3.55-3.5 -13.7456 2004/ -13.7459 palmitoyl -13.7478 butyrophenone -13.7478 glycidol -13.7478 rhodanine -13.7478 ▁Emrys -13.7478 ▁azeotroping -13.7478 ▁selected -13.7478 hexaenamido -13.7479 ⅓ -13.7546 ö -13.8103 ₈ -13.8175 ? -13.8847 ‘ -13.9161 ’ -13.9403 ₇ -13.9991 ⁻ -14.0709 ₀ -14.1789 ₉ -14.1789 | -14.2212 ≤ -14.3236 ß -14.4111 σ -14.4111 ξ -14.4243 à -14.4511 ˝ -14.4648 τ -14.5071 υ -14.5216 ω -14.5363 φ -14.5663 $ -14.6293 ρ -14.6624 ∂ -14.6624 η -14.6966 “ -14.748 ÷ -14.7876 è -14.9089   -14.9529 ≥ -14.9756 ⁴ -14.9756 Δ -14.9952 κ -15.0227 ⁰ -15.0471 ` -15.0721 ¾ -15.1511 ⁵ -15.1788 π -15.2984 ⅕ -15.2984 ⋅ -15.2984 © -15.3306 ⁶ -15.4342 Ø -15.4342 ̂ -15.4712 Ψ -15.5097 ⁹ -15.5097 ⅔ -15.5497 Φ -15.5913 Å -15.6311 ˙ -15.6803 ≅ -15.6803 ι -15.7279 ⁢ -15.7779 ∗ -15.8305 ⊕ -15.8305 └ -15.8305 ≃ -15.8861 ø -15.9449 ● -15.9449 § -16.0741 ο -16.1455 〉 -16.1455 ⟧ -16.2224 » -16.3057 ϕ -16.3057 ∝ -16.3967 ‡ -16.3967 ∞ -16.3967 ⁷ -16.3967 î -16.4967 θ -16.4967 ♀ -16.4967 ∘ -16.6078   -16.6078 Ä -16.6078 ∈ -16.6078 χ -16.7328 ‰ -16.7328 † -16.7328 ^ -16.7328 ⁸ -16.7328 ∅ -16.8756 ⅛ -16.8756 ⟦ -16.8756 ̃ -17.0423 ψ -17.0423 ⃝ -17.0423 ∫ -17.0423 í -17.2423 Σ -17.2423 Ω -17.2423 ⊐ -17.2423 ⌀ -17.2423 Õ -17.2423 Λ -17.2423 ≒ -17.2423 Ú -17.4923 ⅙ -17.4923   -17.4923 ê -17.4923 û -17.4923 ̊ -17.4923 ∥ -17.8256 ┘ -17.8256 Γ -17.8256 £ -17.8256 Â -17.8256 å -17.8256 ô -17.8256 ̇ -17.8256 Ξ -17.8256 ⇒ -17.8256 Ⓡ -17.8256 ┐ -17.8256 ◊ -17.8256  -17.8256 ∀ -17.8256 △ -18.3256 ¯ -18.3256 ¶ -18.3256 á -18.3256 ÿ -18.3256 Ε -18.3256 ζ -18.3256 ₋ -18.3256 ℑ -18.3256 ≠ -18.3256 ␣ -18.3256 õ -18.3256 ‥ -18.3256 ◯ -19.3239 ② -19.324 ∧ -19.3241 ʺ -19.3242 ë -19.3243 â -19.3244 À -19.3245 « -19.3246   -19.3247 ↑ -19.3248 ç -19.3249 Á -19.325 ï -19.3251 〈 -19.3252 ↓ -19.3253 Ö -19.3254 ƒ -19.3255 ‴ -19.3256 Ü -19.3256 ű -19.3256   -19.3256 ¢ -19.3256 ¬ -19.3256 Æ -19.3256 Ê -19.3256 Ì -19.3256 ì -19.3256 ò -19.3256 ó -19.3256 ú -19.3256 ́ -19.3256 Π -19.3256 ‾ -19.3256 ⅖ -19.3256 ​ -19.3256 ≧ -19.3256