base_model: westlake-repl/SaProt_35M_AF2
library_name: peft
Base model: westlake-repl/SaProt_35M_AF2
Model Card for Model ID
This model is trained on a sigle site deep mutation scanning dataset and can be used to predict fitness score of mutant amino acid sequence of protein AsCas12f.
Protein Function
AsCas12a is widely utilized as genome-editing tools in human cells.
Task type
protein level regression
Dataset description
The dataset is from An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.
Label means fitness score of each mutant amino acid sequence. Ranging from negative infinity to positive infinity. The wildtype sequence has fitness 1. If the effect larger than 1 represents high fitness, smaller than 1 represents low fitness.
Model input type
Amino acid sequence
Performance
0.60 Spearman's ρ
LoRA config
lora_dropout: 0.0
lora_alpha: 16
target_modules: ["query", "key", "value", "intermediate.dense", "output.dense"]
modules_to_save: ["classifier"]
Training config
class: AdamW
betas: (0.9, 0.98)
weight_decay: 0.01
learning rate: 1e-4
epoch: 50
batch size: 36
precision: 16-mixed