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Who doesn't love getting free printables? Especially if it means keeping your busy preschooler busy so you have a few more minutes with your older ones! Am I right? We have been having so much fun with this spring preschool printable pack! These 17 pages are packed full of some fun activities for your little one including coloring pages, counting, learning their shapes, learning to write their alphabet and so much more! Keep your preschooler occupied during those spring showers with a little bit of education at the kitchen table. Everything is in black and white making it easy on your printer and full of cute little graphics for your little one to color in! Make sure to pin this image for later! Grab your Free Spring Preschool Printable Pack! Did you know I create a new free printable for you guys every. single. week? From math worksheets to coloring pages to unit studies, there is a huge variety of fun little goodies that I send out weekly to my subscribers. I even have a free gift for you for subscribing, a full 2-week unit study on beavers for children grades K-3. As soon as you confirm your subscription you'll get your free unit study link immediately in your inbox. If you are looking for weekly encouragement, resources, and a sense of community, I promise you'll enjoy my weekly e-mails! I have now released the adjoining summer printable pack, you can find it HERE. Also stay tuned for a co-ordinating fall and winter themed pack that can be used year round! If your preschooler enjoys this printable pack, share their creations with me on Instagram by tagging me (@rebeccaspoonerpg) or tag your pictures #rebeccaspoonerpg on your Facebook page so I can see all the awesome work they have sone on the spring preschool printable pack. You can also post on my Facebook page! I can't wait to see their worksheets! Does your preschooler like doing school? Comment below!

Frottage Share glossary term All glossary terms A technique in which paper or canvas is placed over a grainy surface and rubbed with a crayon or charcoal. This was often used by Surrealist artists to create chance effects. From the French word 'frotter', meaning 'to rub'. Max Ernst Elle garde son secret [She Keeps Her Secret] 1925 © ADAGP, Paris and DACS, London 2021 Origins of the Technique: Max Ernst Surrealist artist Max Ernst was the first to pioneer the frottage technique and to give it the name. The French word 'frottage' had erotic associations which suited the Surrealist fascination with Sigmund Freud's theories around sexual association and dreams. Ernst was first inspired to try the unusual process by the grainy texture of an old wooden floor, with a richly worn-down patina suggesting curious, hybrid creatures or mystical landscapes. He placed a sheet of paper over the floor and rubbed it with a soft, dark stick of graphite to produce unexpected and surprising outcomes. Pleased with the results, Ernst moved on to rub paper laid across an array of other surfaces including thread, straw, textiles, netting and dried paint. As his confidence grew Ernst began moving the paper while rubbing to allow the original content to mutate into something new. Then, something miraculous happened, as Ernst saw new forms emerging from the paper, which he could rework with passages of drawing, as seen in the artwork Elle garde son secret (She Keeps Her Secret), 1925. He observed, 'When I intensely stared at the drawing won in this manner, at the 'dark spots', and others of a delicate, light, semi-darkness, I was (struck) by the sudden augmentation of my visionary facilities with contrasting and superimposed pictures.' In the print series Histoire Naturelle (Natural History), 1926, based on Ernst's frottage drawings, we see the results of Ernst's visionary imagination as pictorial realms emerge from unusual textures featuring curious hybrid creatures and mystical, magical forests. Following on the success of these prints Ernst continued to experiment with how frottage techniques could be incorporated into his paintings and collages, taking rubbings from a further array of pre-existing surfaces and developing similar techniques of scraping or 'grattage' with oil paint on canvas. Ernst's ideas around frottage influenced many of his fellow Surrealists, particularly the artist and collector Sir Roland Penrose. Like Ernst, Penrose took an experimental approach, playing with the ways varying textures within a single image could create a sense of dissonance and transformation in collages and oil paintings. In his collage La Méditerranée, Etude Artistique, 1937, Penrose combines cut out pieces of frottage with fragments of picture postcards, arranging them into discordant shapes and patterns while allowing traces of recognisable imagery to creep through, suggesting just a trace of hidden narrative content. German artist Joseph Beuys was fascinated by Max Ernst, and dedicated his artwork Naturgeschichte (Natural History), 1964-1982 to Ernst's famous 'Natural History' frottage series. In contrast with Ernst, Beuys went directly to the source of the rubbings, presenting a piece of wood resembling floorboards with a richly worn surface, emphasising the same fascination with the mystical and historical properties hidden within the natural materials around us as Ernst. Watch | What is Surrealism? Naturgeschichte [Natural History] Joseph Beuys Painting Sir Roland Penrose La Méditerranée, Etude Artistique Sir Roland Penrose Surrealism was one of the most radical movements of the twentieth century. Founded by the poet André Breton in 1924 it was both a literary and artistic movement. Sir Roland Penrose A radical artistic and literary movement that was a reaction against the cultural climate that supported the First World War. The Dadaists took an anti-establishment attitude, questioning art's status and favouring performance and collage over traditional art techniques. Many Dadaists went on to become involved with Surrealism. A literary and artistic movement that sought to challenge conventions through the exploration of the subconscious mind, invoking the power of dreams and elements of chance. It is now regarded as one of the most radical movements of the twentieth century.

Persistence pays off for Soso December 18, 2019 The National Focus Researcher THERESA MEKI, a PhD candidate with the Department of Pacific Affairs, Coral Bell School of Asia Pacific Affairs, presents her work on how persistence worked for PNG woman politician Julie Soso in her 2012 national election victory IN the systematic analysis of Papua New Guinea (PNG) election data looking at whether women candidates do better when they stand more than once, Terence Wood and Thomas Wangi found that women tend to perform poorly after their first attempt. Their research showed that most of the time, women candidates performed worse the more often they stood. However, there are exceptions. Former Eastern Highlands Governor Julie Soso is one example. I would like to contribute to this discussion by providing a bit of insight into Julie Soso's case. In her first attempt in 1997, Soso managed to secure 5.2 per cent of the 228,639 total allowable ballot, and finished fourth in a field of 36. In her second attempt in 2002, she placed fifth in a field of 26 candidates with 4.9 per cent of the total vote. While she received a smaller percentage of votes, she showed in her second attempt that she still had a substantial vote base. In 2007, with the introduction of limited preferential voting (LPV), the number of candidates vying for the regional seat went back up to 36. That year was Soso's poorest performance, finishing in eighth place. While her 4.7 per cent share of the vote was her lowest, it again showed that she still had a substantial following. Finally, Soso surprised everyone with her 2012 win. She was one of the three successful women candidates in the 2012 national elections, and she credited her win to limited preferential voting, stating that it was the second and third preferences that carried her through. Soso came fourth on first preferences with 8.1 per cent of the vote, her best performance. The 2012 preferential vote accumulation by round – Julie Soso and Sir Barry Holloway. It shows how Julie Soso collected preferences under the LPV system after the twenty-first elimination. And then she accumulated the most preferences. During the final elimination round, she collected 15,800 preferences to pass the absolute majority, totalling 119,606 (of 422,259, or 5 per cent). She beat her nearest rival, Sir Barry Holloway, by 8,130 votes. However, there is more to it. To begin with, prior to her entry into politics in 1997, Soso worked as a radio announcer for the National Broadcasting Commission in Goroka. With such a medium at her disposal, she became well known as she advocated for bans on firearms and liquor in the province. Moreover, in the 1990s, she was the President of the Eastern Highlands Provincial Council of Women. Hence, she was a popular women's leader in the province prior to becoming a politician. While election results do not reveal the demography of voters, it is safe to state that it was the women of Eastern Highlands who comprised her average 4.9 per cent base vote over the three elections from 1997 to 2007. They wanted her in parliament, and they made it happen. It is also important to remember that Julie Soso, as an established entrepreneur, had the funds to contest multiple times and to maintain her support base. This fact alone significantly separates her from other women candidates, who may not be able to afford to roll out consecutive campaigns. The fact that some women perform poorly in their second attempt could be due to various factors such as the pool of candidates, the economy, local politics, election administration and their campaign strategy. But what Soso's winning example teaches us is the importance of maintaining a solid support base from one election year to the next. Of course, there is also the fact that in 2017 Soso lost her seat. Again, however, she maintained her base with 6.8 per cent of first votes. But she did worse with preferences. Table 1 shows Soso's performance over time from when she first ran in 1997, until her victory in 2012 and defeat in 2017. Wood and Wangi had two pieces of advice for women candidates: first, don't assume your results will improve if you stand again next election; and second, don't assume that if you did lose this time that you're destined to fail next time. Overall, what Julie Soso's political career shows is the importance of their second point. In PNG elections, persistence can pay off. Theresa Meki is a PhD candidate with the Department of Pacific Affairs, Coral Bell School of Asia Pacific Affairs. Her research focuses on women's presence and vote share in Papua New Guinea's election history. This article first appeared on the DevPolicy Blog, published by the Development Policy Centre at the Crawford School of Public Policy, The Australian National University. Tanuvasa wants equality

Genitourinary symptoms with reboxetine Reboxetine (Edronax) is a selective noradrenaline reuptake inhibitor for the treatment of major depression. ADRAC has received 130 reports concerning reboxetine. Genitourinary problems, occurring within 5 weeks of commencing therapy, were described in 41 reports. In 26 reports patients developed urinary symptoms consistent with obstruction including hesitancy, reduced urine flow, retention, and dribbling post micturition. All but 6 of the patients were male. During short-term clinical trials, urinary retention was reported in 3% of patients and impaired urination in 4.6%.1 ADRAC has also received 22 reports of male sexual dysfunction including ejaculation disorder (7 reports), erectile dysfunction (4) and pain or swelling of the testicles or external genitalia (10). Two additional reports were of increased libido in women. In short term clinical trials, abnormalities of sexual function and impotence were reported in 1.3% and 1.6% of patients, respectively.1 Testicular pain is a very unusual adverse reaction. It has also been associated with mazindol (Sanorex) an anorectic drug no longer marketed in Australia which has a similar structure to reboxetine.2 Patients prescribed reboxetine should be asked about symptoms of urinary obstruction and sexual dysfunction soon after commencing therapy. Edronax, Australian Product Information, Pharmacia Australia Pty Ltd. 1 Sep 2004 McEwen J. Meyboom RH. Testicular pain caused by mazindol. Brit Med J 1983;287:1763-4. Volume 24, Number 3, June 2005 tetracyclin 250mg tetracyclin quinoloner tetracyclin 250mg

As we know that the active life of a SIM card is a vital thing that you should not underestimate. If your card's active period is up, your card will be scheduled to be blocked by the provider. Blocking is negative as you can no longer send or receive SMS / calls, can not surf and so on. However there are some cases where mobile phone users have many pulses but rarely the card is used for SMS / phone, so pulsanya durable because it is not used. However, the pulses used or not used have no effect on the active period. The active life of a SIM card will remain unchanged unless you purchase a credit or extend the active period. In this article, I will explain in detail how to extend the active life of Indosat / Im3 easily. 1. Here I want to extend my active life of my Indosat Card to increase 30 days. Therefore open Message / Messaging then just type Active 30 then send to 555 . Next select Send / Send . 2. If you get a notification like this, just select Send . 4. Please check the active life of your Indosat card by pressing * 123 * 30 # . The image below shows before and after I extend the life of my Indosat card. That is a tutorial on how to extend the active life of Indosat with easy. Oh yes, SMS reply from 555 long enough, in the above tutorial, I waited for about 1 hour's. I do not know why, maybe that time again trouble or how, I do not know. So I suggest, before you receive SMS reply from 555, do not use your credit for SMS, telephone or internetan. Afraid, your request to extend the active period later failed due to insufficient credit.

The Many Emotions Of Animals In this excerpt of "Mama's Last Hug" by Frans de Waal, learn about the animals that express gratitude, seek revenge, and are even hopeful. by Frans de Waal, on March 14, 2019 The following is an excerpt of Mama's Last Hug by Frans de Waal. Science often compares adult apes to children, as in "the chimpanzee has the mind of a four-year-old." I never know what to do with such statements, though, given that I find it impossible to look at an adult chimpanzee as a child. A male is interested in power and sex and prepared to kill for it. If he is high-ranking, he may adopt a leadership role, which includes keeping order and defending the underdog. Males engaged in power struggles sometimes have a permanently furred-brow expression suggesting internal turmoil, and they are known to have high levels of stress. A female ape, on the other hand, is mainly interested in her offspring and the duties that come with motherhood, such as taking time to nurse, finding food, and deterring predators and aggressive members of her own species. She also works every day on her relationships, grooming her friends, consoling them after upheavals, and watching over their offspring if needed. The lives of adult apes center very much on adult concerns, therefore, and share little with a child's insouciance. Mama's Last Hug Juvenile apes squabble over food and hit each other screaming over the head, while adult apes politely beg and share, sometimes taking turns, while exchanging food for services received earlier in the day. Here, too, the best comparison is between ape and human juveniles or ape and human adults. This matters in relation to emotions, because some emotions are typical of adults, especially those that require a greater appreciation of time than is found in the young. Youngsters live in the moment, while adults don't. Some emotions are future oriented, such as hope and worry, while others relate to the past, such as revenge, forgiveness, and gratitude. All these timeline emotions, as I like to call them, seem present in adult apes and in some other animals as well. In chimpanzees, sharing food is part of a give-and-take economy that includes grooming, sex, support in fights, and other types of aid. All these favors are thrown into one big exchange basket glued together by the emotion of gratitude. Gratitude functions to maintain balance sheets of exchange: it prompts individuals to seek out those who have been good to them, and—if the occasion arises—return their favors. Based on thousands of observations, we have found that chimpanzees share food specifically with those who have been kind to them in the past. Every morning, when the apes gather in the climbing frame to patiently tend each other's hair, we measure who grooms whom. In the afternoon, we provide them with shareable food, such as a few large watermelons. Melon owners allow anyone who has groomed them to remove pieces from their hands or mouth, but not individuals with whom they failed to interact in the morning—they may resist the latter individuals and sometimes even threaten them. Sharing patterns thus change from day to day depending on the distribution of earlier grooming. Since the time span between the two events is several hours, the sharing requires memory of past encounters and positive feelings about enjoyed services. We know this combination as gratitude. Related Segment Primatologist Frans de Waal Explores Animal Emotions Mark Twain once quipped, "If you pick up a starving dog and make him prosperous, he will not bite you. This is the principal difference between a dog and a man." In my own home, adopted stray pets have always been most grateful for the warmth and food we offer. A scrawny kitten full of fleas, picked up in San Diego, grew into a gorgeous tomcat by the name of Diego. Diego purred excessively his entire fifteen-year-long life whenever he was fed—even when he barely ate anything. We interpreted his behavior as gratefulness, but it is hard to exclude mere happiness. Diego may just have enjoyed food more than your average spoiled pet. In apes, signs of gratitude may be more obvious. Two chimps had been shut out of their shelter during a rainstorm. Wolfgang Köhler, the German pioneer of tool use studies, happened to walk by and found both apes soaking wet, shivering in the rain. He opened the door for them. Instead of hurrying past him to enter the dry area, however, the chimps hugged the professor in a frenzy of satisfaction. Their reaction resembles that of Wounda, a chimpanzee who had been rescued from poachers, near death, and received medical care at the Tchimpounga Rehabilitation Center in Congo- Brazzaville. In 2013 she was released back into the forest. A video of this moment went viral because of the emotional interaction between Wounda and Jane Goodall, who attended her release. At first Wounda walked away, but she then hastily returned to hug the people who had taken care of her. She specifically turned to Goodall for a long mutual embrace before taking off. This was remarkable because Wounda had first been on her way, then seemed to correct herself and return, as if realizing it wouldn't be very nice to just walk away from those who had saved her and nursed her back to health. Similar accounts exist of netted or beached dolphins and whales that human divers cut loose from nets or pushed back into the ocean. The cetaceans returned to their rescuers and nudged them or lifted them half out of the water before swimming away. In all cases, the humans present, deeply moved, viewed these interactions as signs of gratitude. I have already mentioned how Kuif, Mama's best friend, was affected by my teaching her how to raise a baby on a bottle. From the moment we gave her permission to pick up Roosje, the adoptive baby we put in the straw of her bedroom, she treated me as family, something she'd never done before. I saw this as a sign of gratitude for changing her life for the better, from a mother who had lost several infants due to lactation failure to one who successfully raised Roosje and later applied the same bottle skills to her own offspring. The ugly sister of gratitude is revenge, an emotion equally concerned with the squaring of accounts, but in a negative sense. Edvard Westermarck, the Finnish anthropologist who gave us the first ideas about the evolution of human morality, stressed the value of retribution in keeping people in line. He didn't think we were the only species with this tendency, but in his time, there was little animal behavior research. So he relied on anecdotes, such as one he heard in Morocco about a camel that had been excessively beaten by a fourteen-year-old boy for turning the wrong way. The animal passively took his punishment, but a few days later, while unladen and alone on the road with the same conductor, it "seized the unlucky boy's head in its monstrous mouth, and lifting him up in the air flung him down again on the earth with the upper part of the skull completely torn off, and his brains scattered on the ground." Stories of resentful animals can often be heard at zoos, usually concerning elephants (with their proverbial memories) and apes. Every new student or caretaker working with apes needs to be told that they won't be able to get away pestering or insulting them. An insulted ape remembers and will take all the time in the world for the right opportunity to get even. Sometimes it doesn't take long. One day a woman came to the front desk of a zoo where I worked complaining that her son had been hit by a rock coming from the chimpanzees. The son was surprisingly subdued, however. Witnesses later told us he'd thrown the same rock first. Calling all word nerds! Sign up for an email about words and language, and updates about the Science Diction podcast. Among themselves as well, chimps retaliate. They support each other in fights, following the rule that one good turn deserves another; experiments have confirmed this tendency. Given a chance, many animals are prepared to do a partner a favor, such as by pulling a lever or selecting a token that produces food. They do so at a moderate level as long as their partner is a passive recipient, but they dramatically increase their generosity when the partner is allowed to return the favor. When both parties stand to gain, they move to a new stage. This is of course also how things work in real life. What may be unique for chimpanzees is that they apply similar tit-for-tat rules to negative acts. They tend to get even with those who have acted against them. For example, if a dominant female often attacks another female, the latter cannot retaliate on her own but will wait for the best occasion. As soon as her tormenter is involved in a brawl with others, she will join in to add to her troubles. After Nikkie became the new alpha male in the chimpanzee colony of Burgers Zoo, he regularly practiced strategic retaliation. His dominance was not yet fully acknowledged, and subordinates would often pressure him, banding together and chasing him around, leaving him panting and licking his wounds. But Nikkie did not give up, and a few hours later he'd regain his composure. The rest of the day he'd go around the large island to single out members of the resistance, visiting them one by one while they were sitting alone minding their own business. He'd intimidate them or give them a beating, which likely made them think twice before opposing him again. This eye-for-an-eye tendency is so prominent in chimpanzees that it can be statistically demonstrated in thousands of observations in our database. Retaliation is an "educational" reaction that attaches costs to undesirable behavior, but it is unclear if the apes themselves think along these lines. They probably just follow an urge to take revenge, a tendency we share with them. After all, we call revenge "sweet," as if it were something delicious. When experimenters gave human subjects voodoo dolls representing people who had insulted them, their mood improved markedly when they were allowed to stick needles into those dolls. Our judicial systems take the longing to get even a step further: when the family of a murder victim or those who have been scammed out of money seek redress, they are undeniably driven by a deep desire to inflict harm on those who have done harm to them. Chimpanzees do the same, thanks to their flexible hierarchy that offers room for retaliation. Rhesus macaques and baboons, in contrast, have such despotic hierarchies that it is almost suicidal for a subordinate to turn against a superior. Intimidation and punishments always flow down the hierarchy, which excludes opportunities for revenge. But even these monkeys know how to hit back: they rely on the kinship bonds that pervade their society. Grandmothers, mothers, and sisters spend extraordinary amounts of time together, forming tight units known as matrilines. A monkey who has become a victim of aggression will likely vent his feelings on a relative of the attacker. Instead of retaliating, which he can't, he will look for a younger member of the attacker's matriline, who will be easier to intimidate. They sometimes perform vindictive actions after quite a delay, suggesting they have excellent memories. This tactic obviously requires monkeys to be aware of the family to which every other monkey belongs, and we know they are. It would be as if I responded to a reprimand from my boss by yanking the hair of his young daughter. I don't go against the pecking order, but I still punish my offender. The final emotion concerning past events is forgiveness. Having studied primate reconciliation all my life, I have seen many times how chimpanzees kiss and embrace their former adversaries, how monkeys groom them, and how bonobos resolve social tensions with a little sex. This kind of behavior is not at all limited to primates: hundreds of reports find it in other social mammals and in birds, so much so that if anyone were to claim that a given species doesn't make up after fights, we'd be baffled. Conflict resolution is part and parcel of social life. The emotions involved are hard to pinpoint, but a minimum requirement is that anger and fear—the typical emotions during a confrontation—are toned down in order to permit a more positive attitude. This reversal is rather counterintuitive. Someone who has just lost a fight with a dominant attacker now needs to pluck up the courage to approach him or her for a friendly reunion. Meanwhile the aggressor must suddenly drop the enmity, which is illogical. But many animals undergo these emotional changes remarkably rapidly, as if a control knob in their mind were turned from hostile to friendly. Humans become masters at turning the same emotional knob if we live in a conflict-prone environment, such as a large family or a workplace with lots of colleagues. These places require compromise and forgiveness every day. Forgiveness is never perfect, though, and even though we often say "Forgive and forget," the forgetting part is problematic. We don't erase the memory of a slight but simply decide to move on. Many group-living animals do the same because they, too, depend on peaceful coexistence and cooperation. Reconciliation is the observable process, whereas forgiveness is how it is internally experienced. Given the evolutionary antiquity of this mechanism, it is hard to imagine that the emotions involved are radically different between us and other species. All three emotions—gratitude, revenge, and forgiveness—sustain social relationships based on years of interaction among individuals, sometimes going back to when they played together as youngsters. These emotions serve friendships and rivalries, enhance or harm trust, and keep the society functioning to everyone's advantage. Animals are remarkably good at this balancing act, which requires them to exchange favors and resolve tensions. We know now that monkeys (and probably other animals as well) have dedicated brain networks that help them process social information. These neural networks have been tested: while monkeys watch televised scenes and see their fellows engage in social affairs, they are activated, but they remain inactive during physical or ecological scenes. Students of animal behavior have for a long time insisted on the special status of social intelligence: neuroscience is now backing us up. Are there also emotions concerned with the future? It is well established that apes and some large- brained birds do not live purely in the present. Wild chimpanzees plan ahead by picking up tools hours before they arrive at the termite hill or beehive where they will use these implements. While collecting them, they must know where they are going. Similar planning has been demonstrated in primates and corvids, showing they may ignore immediate gratification to reap future benefits. Given a choice, apes will forgo a juicy grape placed right next to a tool that they can use only hours later for a better reward. This takes self-control. Planning is harder to prove in the social domain, even if the political battles among male chimpanzees are suggestive. When a young adult male challenges the established boss, he may lose about every confrontation and sustain frequent injuries. Yet he will keep going day after day without any immediate rewards. Only months later he may finally have a breakthrough and get support from others who help him topple his adversary. And even then, as was the case with Nikkie, the young male may still meet resistance before he is fully accepted. It may take years before his position is truly secure. Was this his plan all along? And if not, why go through this hell? It is hard to watch these strategies, as I have done so many times in my career, and not think that they are built on hope. "Hope" is rarely attributed to animals, but the related idea of "expectation" was proposed already a century ago. The American psychologist Otto Tinklepaugh conducted an experiment in which a macaque watched a banana being placed under a cup. As soon as the monkey was given access to the room, she ran to the baited cup. If she found the banana, everything proceeded smoothly. But if the experimenter had surreptitiously replaced the banana with a piece of lettuce, the monkey could only stare at it. She'd frantically look around, inspecting the location over and over, while angrily shrieking at the sneaky experimenter. Only after a long pause would she settle for the disappointing vegetable. Tinklepaugh demonstrated that instead of a simple association between location and reward, the monkey recalled what she had seen being hidden. She had an expectation, the violation of which greatly upset her. Primates and dogs react with similar surprise when human magicians make things miraculously disappear or conjure them out of thin air. Apes may laugh or look puzzled, while dogs madly search for the vanished treat, indicating that the reality they had in mind was different. Expectations also feed tit-for-tat barter, which is well known among animals despite Adam Smith's claim that "nobody ever saw a dog make a fair and deliberate exchange of one bone for another with another dog."16 Smith may have been right about dogs, but wild chimpanzees in Guinea are known to raid papaya plantations in order to buy sex. Adult males usually steal large fruits, one for themselves, the other for a female with a genital swelling. The female waits at a quiet spot while the male risks the anger of farmers in order to bring her a delicious fruit, which he hands to her during or right after sex. In another instance of tit for tat, the long-tailed macaques at some Balinese temples have a habit of stealing valuable objects from tourists. At temple entrances, written signs warn everyone to remove their glasses and take off their jewelry, but many tourists fail to do so, not realizing how incredibly fast the monkey mafia operates in these places. A monkey will jump onto their shoulder to snatch a pair of glasses or run off with a precious smartphone. They will steal flip-flops by literally removing them from the tourists' feet. Instead of playing with these items or taking off with them, the monkeys sit down patiently nearby, but out of reach, to see how much their victim is willing to pay to get an item back. A few peanuts won't do. The monkeys want at least a whole bag of crackers before they will drop the item. Primatologists who studied this extortion game found that the monkeys had a pretty good idea of which objects humans value the most. Given the existence of future-oriented behavior, dogs have recently been classified as either "optimistic" or "pessimistic" while facing a given task. Dogs that get seriously upset when their owner leaves them alone at home—venting their frustration by destroying the house, relieving themselves, or furiously barking—are regarded as pessimistic. When presented with a food bowl of unknown content, they hesitate and approach slowly, perhaps expecting the bowl to be empty. Dogs that are less perturbed by separation, on the other hand, are considered more optimistic: they happily run toward the bowl, expecting it to be full. This so-called cognitive bias is also common in people. Cheery, easygoing people expect good things in life, whereas depressed ones believe that everything that can go wrong will go wrong. Cognitive bias offers us a rare opportunity to test how farm animals feel about their living arrangements. After all, pigs that live under stress in small crates may expect few good things to happen to them. But those that live in a fun environment, with straw to burrow into while sleeping in piles, enjoying body heat and physical contact, may be in better spirits. In one study, groups of pigs were housed either in small pens with concrete floors or in larger pens with fresh straw every day and cardboard boxes to play with. All the pigs were trained on two different sounds: a positive sound would announce a slice of apple, and a negative sound announced only a plastic grocery bag waved in the pig's face. Being intelligent, the pigs quickly learned to go for the positive sound. After this training, the pigs were presented with an ambiguous sound, somewhere between the other two. What would they do? It depended entirely on their living conditions. The pigs in the enriched environment expected good things to happen and eagerly approached the ambiguous sound, but the ones kept in the barren environment did not see things the same way. They stayed away, perhaps expecting that stupid plastic bag again. If their housing was changed for better or worse, the pigs' responses to the ambiguous sound followed suit, indicating that their daily life affected how they perceived the world. The cognitive bias test is informative, allowing us to verify the claims of companies that advertise their products as coming from happy animals, such as the well- known French spreadable cheese La vache qui rit (The Laughing Cow). The test can tell us if these animals really have anything to laugh about. The condition of looking forward to something desirable is what we call "hope." A monkey looking for a lucrative trade, a chimpanzee trying to improve his status, a dolphin searching the ocean for her lost calf, wolves setting out on a hunt, or a herd of elephants following an old matriarch who knows the last watering hole in the desert—all may well experience hope. It may be present or absent in farm animals as well. Like us, many animals evaluate everything that happens to them against a backdrop of past and future. Timeline emotions that transgress the present can no longer be denied, given the mounting evidence that animals hold memories of specific events, are forward- looking, exchange favors, and engage in an eye-for-an-eye. Reprinted from Mama's Last Hug by Frans de Waal. Copyright 2019. Used with permission of the publisher, W. W. Norton & Company, Inc. All rights reserved. Donate To Science Friday Invest in quality science journalism by making a donation to Science Friday. Meet the Writer About Frans de Waal Frans de Waal is the C. H. Candler Professor at Emory University and director of the Living Links Center at the Yerkes Primate Center. De Waal lives in Atlanta, Georgia. How Do You Measure the I.Q. of an Octopus? The trick, says primatologist Frans de Waal, is to measure animal intelligence not by human standards, but by the standards of an octopus or elephant or chimpanzee. Searching for the Roots of 'Right' and 'Wrong' Primatologist Frans de Waal explores the origins of morality in The Bonobo and the Atheist.

ComicMix Six: Original Star Trek Backstory by Glenn Hauman · May 9, 2009 The new Star Trek movie is in theaters, introducing the characters to new fans and surprising old fans. As anyone who's read a single review, interview or promotional piece is aware of, this movie features some alterations to Trek's past thanks to a little time travel manipulation. But what about the original past and backstory? What did the original series establish when it went on the air? Here then are a list of six stories from the television series that filled us in on just who these folks were before they joined the crew of the U.S.S. Enterprise NCC-1701. "The Naked Time" When the Enterprise was infected with a virus that destroyed inhibitions, the crew went a little nuts. For the first time, audience learned about the emotional turmoil that sometimes affected Spock, how even feeling friendship towards his captain could simultaneously cause his Vulcan half to experience shame. We also saw that Kirk sometimes resented his job, that he felt tethered by responsibilities that did not allow him a relationship or a family. This adventure was also the crew's first experience with time travel, making it a significant precursor to the new film. "Operation: Annihilate!" Kirk and the Enterprise attempt to rescue a colony that has been seized by madness. In this adventure, audiences met Kirk's brother George Samuel Kirk, Jr. and learned about the Captain's sister-in-law and nephew. In this story, Kirk learns of the Pon-Farr, the Vulcan "time of mating." Every seven years, all the repressed primal urges of a Vulcan male suddenly rise and overcome him with madness. He must choose a mate or die. The Enterprise then introduced us all to the planet Vulcan and to the fact that its people were mystics as much as scientists. "Journey to Babel" Though Spock had occasionally referred to his parents, this was the first time we or the Enterprise crew met them. We learned about the disagreements between Spock and his father Sarek, who could not understand why his son had not accepted his invitation to the Vulcan Science Academy. And we saw that, despite marrying a Vulcan and living on the desert planet for years, Spock's mother Amanda Grayson was openly emotional and not afraid to show that she was proud of both her husband and her son. "The Menagerie" Using footage taken from the original Star Trek pilot (entitled "The Cage"), this two-part story involved Spock revealing to Kirk details of a significant mission from the past, when he had served under the Enterprise's original Captain Christopher Pike. Pike plays a significant role in the J.J. Abrams film, making this adventure of interest to new fans. An episode of the animated series, this adventure finally gave us some real background information about McCoy's family. We learned that he had gone through a bitter divorce. What's more, we found out about his daughter Joanna, whom he did not often get to see. And that about wraps it up, folks. Honorable mention goes to the Next Generation two-part adventure "Unification", which revealed more details about Spock's childhood and acts as a set-up for the recent IDW comic book mini-series Star Trek: Countdown, a direct lead into the new film. Alan "Sizzler" Kistler misses seeing Shatner, Nimoy and Kelley kicking butt in the stars. He has been recognized by Warner Bros. Pictures and mainstream media outlets as a comic book historian, and can be seen in the "Special Features" sections of the Adventures of Aquaman and Justice League: New Frontier DVDs. His personal website can be found at: http://KistlerUniverse.com. One of these days he'd love to write for DC, Marvel or Doctor Who. Tags: AquamanComicMix SixcomicsDCDoctor WhofilmIDWJr.Justice LeaguereviewStar TrekWarner Bros Dwayne McDuffie and Earl Kress to Receive WGAW Animation Writing Awards MICHAEL DAVIS: In The Ghetto Bleeding Cool debuts Jonathan (the other says: Let us not forget "Obsession", in which we learned that Lt. Kirk had served aboard the USS Farragut under Capt. Garrovick some eleven years before, and blamed himself for a creature slaughtering half the crew. (Turned out it hadn't been his fault – no matter how promptly he had opened fire, his phaser would have been nothing more than a bright flashlight to the creature…) Alan Kistler says: Another excellent one. I was also thinking of the animated episode, "Yesteryear." It reinforces Spock's family relationships established in "Journey to Babel," and acts as a strong precursor to the new movie. Young Spock confronting bullies and older Spock interferes with his personal timeline. Another excellent choice, I only didn't include it because the list was becoming too Spock-heavy. Sean D. Martin says: Or "Shore Leave" where we meet Ruth and Finnegan. A highlight and lowlight from his academy days.(Which, given Kirk has now entered the Academy several years later than in the original timeline, he would now NOT know. (Or Carol Marcus. Nor would he serve on the Farragut(?) so he has nothing to have an "Obsession" about.)) I did consider Shore Leave but figure it was such a small thing, mentioning two people in Kirk's past with so little details, that the other episodes surpassed it in making it to the 6 List. "Conscience of the King" reveals Kirk's childhood experience on a failed colony where a despot executed half of the population so the rest could survive. Next story The Empire isn't letting the Federation hog all the glory this weekend… Previous story Friday Night Fights: Spock vs. Wolverine!

Under LXDE desktop manager Alt+F11 can be used to switch a program to full screen. I use this shortcut so often that'd I rather have certain programs always open in full screen instead of doing it manually. Is it possible to define some system configuration, or a shell script that'd always launch particular programs in full screen? (Particular not all because I wouldn't want certain small windows like network configuration window and system calendar to open in full screen). and then click with your cursor inside the app window. Not the answer you're looking for? Browse other questions tagged lxde lubuntu fullscreen or ask your own question. How do I make an application beep when I click on it to launch it?

Which foods should children eat has always been a topic that plenty parents care about. You can make the best and healthiest foods in the world, but whether your kids eat them is a whole different thing. And that makes you always wonder if your children are receiving enough nutrients needed for them to grow up. If you are still carrying that question, you can read the following types of the most nutrient food to find out the answer. Moreover, I would also introduce to you an Airfryer Healthy, which can delight your children with all the fries they love but still not affect their health. Mango is one of the best foods that your kids can eat. It is full of vitamin A, B and C, magnesium and fibrous matter. That is why mango is splendid for eyes, prevents sight-shorted and night-blindness. It also cleans your children's skin by sweeping all the dirt in the pores and eliminating pimples, especially if your kids are in puberty. Moreover, mango can strengthen your children's immune system with vitamin A, C, and 26 types of different carotenoids. Your kids will love mangos if you turn them into delicious foods such as a mango smoothie or pudding. And kids usually love snacks, so you can try by grinding a mango into pieces with a blender, then pouring them into an ice cube trays. Within a few hours of freezing, you children can have the best mango snacks ever. Just like mango, avocado is superb for children's eyes and skin, but it also can prevent obesity. The reason is avocado contains polyunsaturated fats, protein, and high fiber, which control appetite and balance calories inside human bodies. Avocado is also particularly perfect for children in the early years due to its fat intake. Therefore, your kids will always feel full of energy and would not crave for unhealthy junk foods. And avocado gets along with children well if it is mixed with mayonnaise or cheese. Or you can ripe and mash it, then mix it with lemon juice and salt. Your kids will love the best dessert that you made for them. This great pink fish has always been on the list of the most nutrient foods for children. Salmon has a high-fat diet and omega-3, which can develop children muscles and help them grow faster. It also assists metabolism and prevents obesity. Furthermore, DHA found in salmon plays a crucial part in growing brain cells; therefore, your children will get smarter and have a better memory. Various parents usually worry about may contain mercury, which is harmful to their children. The fact is salmon is consistently proved by FDA as one of the five fishes having the lowest amount of mercury. So there is no need to concern.One more fascinating feature that I found in salmon is that it is easy to cook. It can be made with numerous recipes and styles, such as baked or grilled. Salmon with pasta or potato is also the number one choice for your children, especially 7-9-month-old. This is a dish original from the Middle East and Arab, which is rich in nutrition. It is made from well done and pulverized chickpea mixed with tahini sauce, olive oil, lime juice, salt, and garlic. Besides being popular all over Middle East, Turkey, North Africa, and Morocco, it is also a type of food that cannot be excluded from children's diet.Hummus contains a significant amount of iron, vitamin C, acid folic, and vitamin B6. It provides your kids with healthy proteins, fiber, along with calories, which can keep them full and feel energetic until dinner.Moreover, hummus can be served with not only Pita cake but also sandwiches, fries, meat, or seafood. You can add this type of food to numerous recipes, and your children will still love it. It is so familiar with all of us, isn't it? Because it is a product made from milk, it has plenty milk's nutrients, such as iron, zinc, calcium, and all types of vitamins. If your children eat yogurt every day, they will have a better immune system because yogurt increases the number of white blood cells in their body. And it is also extremely helpful for digestion and children's bones, in particular. At your kids' early age and puberty, having yogurt regularly will help them grow fast and increase their height. And most of the children like yogurt so don't worry too much. If they don't want to eat, just mix it with fruits, cream, or jelly, they will love it in no time. Not only people who want to have a perfect body but also children who are growing should eat this. It is proved to be one of the most nutrient foods in the world. It provides your kids with fiber, calories, proteins, vitamin B6, and many others. It is sweet, but it does not raise the level of blood sugar or cause obesity. Furthermore, its vitamins will light your kids' eyes, increase their height, and develop the nervous system, which means that they will get more and more intelligent every day. Besides, you will never have to concern if they had constipation due to the considerable amount of fiber in sweet potato. However, not many kids like this type of food since it looks not so beautiful and unattractive. I did not like sweet potato either when I was small. It's not a problem. You can have plenty tasty recipes that will make your kids love it. My mother usually served it with yogurt, applesauce, or maple syrup, which were all fantastic. You can try if you like. Iron, proteins, and calcium are three essential criteria making tofu the best food for children. It is made from fermented soybean, which is delicious, nutrient, and cheap. Moreover, iron, proteins, and calcium play a necessary part in children's development and performance. Like sweet potato, you may think that your kids will never touch tofu and may even scream "Ewww" when seeing it. Then, you can try adding tofu to their dessert by blending it in smoothies with blueberry, cookies, or cream. Tanya, my daughter, loves the strawberry smoothie made by me but never knows that she is eating tofu with it. It will be fun, so try it. Those are the healthiest foods and recipes that you can add to your children's daily diet. I hope that they will grow much faster and quicker every day as you expect. Now I will show you a machine that can solve your problems when your kids desire for fries. We all know that kids love chips although it is terrible for health. Because they are made from oil, it contains more calories than your children's body needs. Besides, it can cause addiction, and you cannot keep an eye on your kids 24 hours a day. Therefore, they may end up with obesity sometime in the future.So to prevent this, you can use an Airfryer Healthy. It is a machine that can make fries in just a few seconds but not harmful fries. The ingredient uses to make fries done to a turn is hot air, not oil. That is why the fries are still themselves but healthier than when you cook with oil. It can be a beautiful solution for you when your children claim for fries, and you don't want to let them eat unhealthy foods. Moreover, you can use it at an in-house weekend party as well. Everyone can still feel the delicious taste of fries inside their mouth but do not need to worry about high rate of cholesterols or heart risks. And that is the end of my article. Lastly, thank you for reading it, and I wish that your children, as well as each member of your family, would stay as healthy as they are. Lastly, thank you for reading our article, and we hope that you will have the wisest choice to protect your child's health and growth. Goodbye, and see you in the next articles. Thank you to Abigail Karnik for writing this guest post today, Abigail Karnik is the founder of familynano.com and she is a cook, a blogger, and a mother of two children. She used to take part in numerous baking contests all over America and gained plenty awards. She has also been writing a remarkable number of articles about food and nutrient diet for families. She is enthusiastic and loves sharing her experiences about how to protect family's health.

Schools in Italy School in Florence School in Bologna Master of Pasta Master of Pizza Cooking Italian School in Bologna Culinary Masters in a Food Capital Study programs for a new culinary skill Cooking School in Bologna The cooking school in Bologna is located in the center, just 5 minutes from the rail station. It has an area of 350 square meters entirely dedicated to the teaching of Italian cuisine. In addition to the common areas, the washing and pantry area, the cooking school has two perfectly equipped laboratories to accommodate 20 students at a time. Cooking workshops are equipped with a multimedia system to speed up student learning. The area surrounding the school is fool of actractions, just inside history and amenities of this magic city. The school offers regular courses for italian students and the masters for foreign students. «Every student must be able to achieve a real new skill. To do this it can not simply learn a recipe, but also understand the dynamics and the bases that compose it. This will allow the student to vary the recipe and create new ones in pure Italian style. » SCIENTIFIC COMMITTEE AICI Studying cuisine in Bologna, a multi-sensory experience in Food, History and Art. The advantages of studying in a cooking school in Bologna. Your school is in the center of Bologna, one of the italian food capital, full of artistic and culinary wonders. We can try to propose an itinerary in the city of the arcades, through its millennial churches, through its gardens, the trattorias set in the Renaissance palaces. All places are near your cooking school in Bologna. Bologna, one of the most scenographic cities in the world. Thanks to its peculiarities and its rich history is a very popular place with lots of beauties to discover. The presence of the University helps to make it a cosmopolitan city, its towers are famous all over the world, and its history is so rich that important corners, medieval remains and enchanting landscapes are hidden behind every corner. Bologna is an unmissable destination for tourists who are looking for art, culture, excellent gastronomy and escape from their trip to Italy. The city is also known for its nicknames: the learned, the red, the turrita and the fat. Bologna "the learned", so it is defined the capital of Emilia Romagna, thanks to the presence of one of the oldest Italian universities, founded in 1088, still today frequented by local students and university students from abroad. An ideal place to create a Cooking School in Italy. The town of Bologna preserves traces of the past, in a marriage between ancient and modern, which strikes at a glance the tourist: you can walk in Piazza Maggiore and admire in the same instant the oldest buildings of the city, but at the at the same time perceive the cultural ferment that animate an open and tolerant city, ready to welcome ever new artistic and cultural ideas. This place is very near to you Cokking School in Bologna. The history of Bologna begins in 600 a. C., when it was the capital of the Etruscan Empire, then its territory has seen the passage of Gauls and Romans, up to the Byzantines and the Normans. Only by this is it easy to perceive the mixture of styles and cultures that are felt in Bologna. Art and Culture near your Cooking School in Bologna. His university had excellent students: Dante, Boccaccio, Petrarca, Thomas Becket, Erasmus of Rotterdam and Copernicus. In the Middle Ages, like most Italian villages, the Emilian city closed in its walls, but no country reached the Bolognese record, more than 180 watchtowers were built. After various vicissitudes and destructions due to the Wars that struck the city, today Bologna, mindful of its past, is a very important university center and a city full of cultural ferment. The Torre degli Asinelli and the arcades of Bologna The towers are the symbol of the city of Bologna, and a visitor around the city can not miss the two most famous towers, that of the Asinellis and that of the Garisenda. The most famous is the first that was built between 1109 and 1119 by the family that, in addition to receiving social prestige, used it for military purposes of defense and sighting. To date, its 498 steps are climbed by tourists to enjoy a panoramic view of the city from a height that is close to 100 meters from the ground. Moreover, during the sunny days, the view can reach the Romagna sea and the Veneto Prealps. In addition to the Towers, another distinctive feature of Bologna are its arcades. It is impossible to think of the city without associating it with this aspect of its urban conformation. For 40 kilometers the city is crossed by porticos, from the elegant ones of the Church of the Servants to those painted in Piazza Malpinghi. These are covered paths that allow the traveler to reach every point of the city. The origins of the arcades date back to the late Middle Ages when, in a period of rapid expansion, hence the need to make the most of outdoor spaces. The only wooden porch that still survives is that of Casa Isolani in Strada Maggiore. History and Arts near your Cooking School. Bologna is a sort of open-air museum, wherever you breathe art and history. All this is very near to our Cooking School in Bologna, just in the center of the city. The styles that are found in the city range from the Gothic, to the Baroque, to the Romanesque, up to the Renaissance. The city is visited in a few days, even if the things to see are endless, just a bit of organization. The tour of the Emilian city can start from Piazza Maggiore, which is the center of Bolognese life, at the center of which is the famous Fontana del Nettuno. The Piazza is surrounded by the history of the city. From the Palazzo Comunale to the Palazzo dei Bianchi, to the Palazzo del Podestà. The south side of Piazza Maggiore is occupied by the majestic façade of the Basilica of San Petronio, the fifth largest church in the world and the last great Gothic work in Italy. Its late-Gothic naves house the works of Parmigianino and Masaccio and its walls have seen religious ceremonies alternating with civil ceremonies. The interior of the basilica is extremely bright and spacious, dominated by the pink tones of its brick pillars. A belief very popular among the students on Piazza Maggiore wants the Piazza to bring a little bad luck, in fact it is thought that going through the center is bad, and then you always have to coast, otherwise there is the risk of saying goodbye to the long-hoped degree . Another important church is the Basilica of Santo Stefano, which belongs to the complex of the seven medieval churches. The square of Santo Stefano houses: the Church of the Crucifix, the Basilica of the Sepulcher, the Church of San Vitale and Sant'Agricola, the Cortile di Pilato, the Church of the Martyrium, the Medieval Cloister and the Santo Stefano Museum. Today the churches have been reduced to four for renovations. Also worthy of mention is the Church of Santa Maria della Vita, which is the church of the first hospital in Bologna and where the harrowing terracotta group of the "Lamentation over the Dead Christ" is kept. Besides Bologna in the open air, there is also a hidden Bologna, underground, the ancient canals that plowed the city, have been restored and today are visited by thousands of tourists. Returning to the light of the sun, not to be missed, then, is the National Art Gallery, which preserves works ranging from 200 to 700, where there are artists such as Raphael, Carracci, Reni and many other artists related to Bologna. During your trip to Bologna, there will certainly be time to refresh yourself with the goodness of Bolognese cuisine. In the city, just a stone's throw from your cooking school in Bologna, there are many taverns and inns with a great gastronomic tradition, in every street and in every alley you can rediscover the flavors of tradition and smell aromas that are hard to forget. Ragout, Lasagna, tortellini, tagliatelle, crescentine, tigelle and mortadella are just some of the typical products. From the point of view of confectionery, however, the most famous dish is the Certosino, a typical Christmas dessert prepared with honey, candied fruit, pine nuts, almonds, butter, grapes, cinnamon and dark chocolate. All these specialties can be tasted in the many taverns and taverns, just some minutes from your cooking school in Bologna, many of which are family-run and where you can dive into the true flavors of the Emilia tradition, also tasting the specialties and DOC wines of the hills of Bologna, such as Pignoletto, Barbera and Cabernet Sauvignon. Among the most rustic taverns is that Dei Butteri, where you eat anything with your hands; or the two historical trattorias the Osteria De 'Poeti and the trattoria Boni, symbol of Bolognese cuisine. A good relationship between price and quality can be found at the Antica Osteria Romagnola, Ristorante Teresina, Ristorante Biagi or Osteria dell'Orsa. Discover Our Schools and The Special Master in Italian Pasta The Cooking School in Italy Cooking School in Florence The Master in Italian Pasta Students of every age from over the world [email protected] Secretarial hours Mon. - frie. 09AM - 08PM (Italian time zone UTC +2) Click to open a Whatsapp Chat. OUR MISSION: The creation of skilled and creative operators that fit successfully in the world of professionals catering bringing the true Italian style in kitchens all over the world. School in Empoli (Florence) - Accademia Italiana Chef Street: Cantino Cantini 46 [email protected] School in Bologna - Accademia Italiana Chef Street: Borgo di San Pietro 139 A Contacts Us for Information 203, Vjal l-Indipendenza - Zurrieq Malta - ZRQ 2336 MALTA 00356 79888044 - ITALY 0039 3273282497

KUT Newsroom Staff ATXplained In Black America Two Guys on Your Head Weekly News Podcast Views and Brews Arts Eclectic KUTX Videos Business Circle Program Sponsorships Contact Directions CPB Funding Overview KUT Events KUT Radio Schedule BBC on HD2 Schedule © 2021 KUT A service of the Moody College of Communication at the University of Texas at Austin Austin's NPR Station On Air Now Playing KUT 90.5 FM On Air Now Playing KUT HD2 BBC World News On Air Now Playing KUTX 98.9 FM On Air Now Playing KUTX HD2 Austin Music Ginsburg Misses Supreme Court Arguments For First Time After Cancer Surgery By Nina Totenberg Domenico Montanaro Published January 7, 2019 at 8:51 AM CST Associate Justice Ruth Bader Ginsburg poses for the official photo at the Supreme Court in Washington, D.C., on Nov. 30, 2018. Supreme Court Justice Ruth Bader Ginsburg is not taking part in Monday's oral arguments before the court. The 85-year old liberal justice underwent surgery for cancer last month and also recently broke several ribs after a fall. Ginsburg had not missed a day of arguments since she was confirmed to the court in 1993. Despite not physically being at the court, she will be participating in the cases by reading the briefs and the transcripts of the oral arguments. Ginsburg had hoped to be back on the court for arguments, but Dr. Douglas Mathisen, chairman of thoracic surgery at Massachusetts General Hospital, warned that getting back to work too quickly after this kind of surgery could mean "one step forward and five steps back." Ginsburg is expected to make a full recovery and be back on the court. "These days we are seeing more and more patients in their 70s and 80s make relatively quick recoveries," Mathisen said last month before Ginsburg's surgery, "because we are detecting so many more lung cancers at early stages" when treatment is far more effective and successful. This is Ginsburg's third bout with cancer. In 1999, she was treated for colorectal cancer; a decade later, she was treated for pancreatic cancer. Ginsburg is one of four ideologically liberal justices on the court. President Trump has shifted the court in a more conservative direction, appointing two Supreme Court justices — Neil Gorsuch and Brett Kavanaugh. Kavanaugh replaced the court's swing justice, Anthony Kennedy, for whom he clerked. The court this term has deliberately avoided politics in the cases it is hearing, under the leadership of Chief Justice John Roberts, but the prospect of Trump appointing a third justice has liberals very nervous, especially as the 2020 elections approach. Ginsburg has become a cultural icon for the left, with the nickname "The Notorious RBG" getting attached to her for her sharp dissents, and in the past year, there have been at least two widely distributed motion pictures memorializing her life — the RBG documentary, which premiered at Sundance last year, and On the Basis of Sex, which is out in theaters now. Ginsburg is played by Felicity Jones. Ruth Bader GinsburgU.S. Supreme Court Nina Totenberg Nina Totenberg is NPR's award-winning legal affairs correspondent. Her reports air regularly on NPR's critically acclaimed newsmagazines All Things Considered, Morning Edition, and Weekend Edition. See stories by Nina Totenberg Domenico Montanaro is NPR's senior political editor/correspondent. Based in Washington, D.C., his work appears on air and online delivering analysis of the political climate in Washington and campaigns. He also helps edit political coverage. See stories by Domenico Montanaro Armed Activists Demonstrate Outside Texas Capitol To 'Stand Up For Individual Rights' In His Inaugural Address, Biden Seeks To Move Past 'American Carnage' Police Arrest Man With Handgun, Woman Impersonating Officer Near D.C. Checkpoints No, Ruth Bader Ginsburg Does Not Intend To Retire Anytime Soon "I will retire when it's time," the 83-year-old Supreme Court justice said in an interview with NPR. She also shares wedding advice from her mother-in-law and reads a letter from her late husband.

I still can't believe that 2016 is over! There were so many new releases that I didn't get a chance to read in 2016, so this week's topic was easy: "Top Ten 2016 Releases I Meant To Read But Didn't Get To (But TOTALLY plan to)." I had no problem filling this list! Here are my top ten 2016 reads still on my TBR list, in no particular order. Covers link to Amazon (affiliate) or Goodreads. Empire of Storms by Sarah J. Maas: I cannot believe that I haven't read this book yet! I own it in hardback, ebook, and audio…I have no excuse! It's one of the first books on my list to knock off my TBR pile. I'm dying to know what will happen now that Aelin is home, Rowan is with her, and magic is back in the lands. The Shadow Hour by Melissa Grey: I loved the first book in this series SO much. It consumed me when I was reading it. I grabbed a copy of this book as soon as it was released because I need to know what will happen next in this world, but then other matters like moving got in the way of me actually reading it and I found myself looking at it on the shelf instead of actually reading it. Frost Like Night by Sara Raasch: I'm equal parts excited and terrified to read this book. I was not a fan of Ice Like Fire. It was too much of a bridge book IMO and really if it wasn't for the way it ended I wouldn't even want to read this one. BUT I love the characters and I love the world Raasch created so I'm excited to see the conclusion to the series. I'm hoping it wraps up well but I'm a little nervous to read it. Riders by Veronica Rossi: I loved Under the Never Sky by this author! I've read it more than a couple of times and now as I type this I'm thinking it's time for another reread. So when I heard in 2015 that she was writing a new series I was excited. I bought the book when it was released, but somehow I forgot about it *hangs head in shame* It's on my TBR now and I plan to read it ASAP. The Impostor Queen by Sarah Fine: Sarah Fine is one of my favorite authors. I've read all of her books to date, except this one. I'm not sure why I haven't read it yet. It's high fantasy which I love so I've added it to this year's TBR and I'm hoping to read it soon. A Million Worlds with You by Claudia Gray: After the ending of Ten Thousand Skies Above You, I was distraught. Not only do I love these characters and the world Gray has created, I had to wait a whole year for the conclusion. Now that this book is out, I've dreaded reading it. Not because I don't want to read it, on the contrary I do. I just don't want the story to end. I need to know what has happened to Theo, Paul and Meg, but I don't want their story to come to an end. I will read it, and I will read it soon because I NEED to know what's happened, but I will be sad to do so. The Midnight Star by Marie Lu: I have purposely put off this book. I love Adelina. She is such a tortured character that has fallen so far and has become so twisted. She is truly going to be a magnificent villain. I'm a little scared to read it. I've heard it's dark and so I've been mentally preparing myself. I will read this one soon. I have it on hold at the library, I just need to work up the nerve. And I Darken by Kiersten White: I've been excited for this book for a long time. I even have an ARC of it lying around somewhere. The problem is it was released the week I moved this Summer so I forgot about it. I'm ashamed to admit that but I figured it's better to speak honestly than make up some excuse. I'm hoping to knock it off my list soon, as in within the next month. Mainly because I want to read the sequel! Ivory and Bone by Julie Eshbaugh: Another book I have an ARC of that I missed because of moving. I've heard mixed reviews of this book, but I'm still excited to read it. I believe it is a prehistoric retelling of Pride & Prejudice. Props to the author for creativity on that one! I intend to read Empire of Storms at some point this year too! I can't believe that I didn't get around to it last year. I really liked And I Darken but haven't read any of the others yet! Reading time is so precious, I wish I could stretch time! I really enjoyed And I Darken! I hope you get to read it soon. Riders is on my list too. But DROP EVERYTHING AND READ EMPIRE OF STORMS NOW! 🙂 Hope you enjoy all of these! Have a great week! Oohh, they aren't on my list, but I want to read And I Darken and Bright Smoke, Cold Fire, too. I'd hoped to read Riders in 2016 as well, but I never got a chance. That cover is so stunning! I hope you enjoy these when you're able to get to them! Ivory and Bone was pretty good. I hope that you get to all of these in 2017. I don't keep up well with release dates, but if I had my NetGalley self together I could have done this post this week. Oh well. I need to be reading them anyways! And I Darken was on my list this week too. I really enjoyed Empire of Storms when I read it, so I hope you do too! Ooh nice! I'm behind on a lot of my triologies! I was holding off reading all the book 2s since they were all pretty much cliffhangery and then when the book 3s came out I didn't have time to get to them! Going to try to not accept as many review books this year, I felt like every other book I read last year was a review one! Lol. But they were always ones I WANTED to read as well, so it was hard to say no too! Haha! Hope you get to read all of these this year! Great list! I hope you are able to get to some if not all of these this year. I keep kicking myself for not reading Replica and Heartless when I wanted them so bad. I am determined to read them this year!

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Protesters call for the arrest, the firing of Minneapolis officers MINNEAPOLIS – Activists and relatives of a black man who was fatally shot by Minneapolis police last month said Tuesday that the officials should be fired and they continued to call for the police arrest — a day after a prosecutor announced that he was declining to file charges. About 300 people gathered for a protest at the Hennepin County Government Center on Tuesday evening. They held signs calling for justice for Thurman Blevins, who was shot June 23 by Minneapolis officers after they chased him in an alley in north Minneapolis. Hennepin County Attorney Mike Freeman said Monday the actions of Officers Ryan Kelly and Justin Schmidt were justified, because Blevins, 31, was armed, ignored the police commands, and turned in the direction of the police with a loaded gun. Blevins' family members said that he's not a danger while he is absent. His sister, Darlynn Blevins, said her brother "ran for his life" because he was afraid, that the officer "emptied his clip in my brother's back." Sydnee Brown, Blevins' cousin, said Thurman Blevins "was not a evil man on earth." The protesters also shouted that Freeman "should go." The officers were responding to a 911 call of a man firing a gun in the air. Body camera video released Sunday shows Schmidt and Kelly pull their cruiser and Blevins, sitting on a curb near a woman with a child in a stroller. If the officers withdraw, it is said, "He has a gun!" and they jump out of the patrol car. The officers chase Blevins and yelling at him to get his hands up or they will shoot. Blevins says, "Please don't shoot" and "Leave me alone." An improved version of the videos is a red circle drawn around what looks like a gun in Blevins' right hand. The video shows that it will come into view as he looks over his shoulder at the officers, before he is shot. LAPD chief: Officers to kill a hostage for the 1st time in 13 years White Michigan officer, who said he suffered discrimination after learning he is part black and settles in the lawsuit to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com The California Highway Patrol said Monday that the truck driver deliberately rammed his vehicle into a Toyota... Kansas City bar shooting suspect identified to connectVideoPolice say 2 dead, possibly 15 people injured in a Kansas City bar shooting The police in Kansas City, Missouri, say that two people are dead and at least 15 people were injured in a shooting outside a bar that they were going to keep... Avenatti, reportedly took control of the money from the football fans to connectVideoWhatever Happened to Michael Avenatti? The Celebrity's lawyer, Michael Avenatti was a media darling of a topic in the media and in the judicial review; Robert Gray reports. LOS ANGELES – disgraced lawyer Michael Avenatti accused... A Dallas girl, 9, wounded by gunfire, in the movement of the car on the highway, the police said to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com Dallas police say one man is injured and a 9-year-old girl after the recording of not less than three times... Hawaii for a man who allegedly shot and killed, 2 officers, had a history of disputes with the law to connectVideo2, police reportedly shot and killed in Honolulu. The suspect and a number of neighboring houses on fire, after a man allegedly opened fire on police officers responding to an assault call in the area at the foot of Diamond Head. A... Florida man tries to hide underwater, and the police will be arrested, and, after coming up for air, police say to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com A Florida man tried to have a "not so " great escape" last week, when he was trying to hide... 'Pillowcase Rapist" who terrorized women decades ago was arrested in Florida, police say to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on FoxNews.com One of the state's most hunted criminals in a notorious sex fiend, known as the "Pillowcase... California tries to kill convicted child molester, after hitting him over the head with a stick to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com An inmate at a central California prison and slapped with a convicted child molester over the head with a... North Carolina, a mother, a son, was found after being kidnapped at gunpoint, search on for suspected kidnapper knew the police to connectVideoFox News Flash, important news, Jan. 20 Fox News Flash-main news, Jan. 20 to be here. Check out what to click on Foxnews.com A North Carolina mother and her one-month-old son — who police say were kidnapped during an overnight... Is it Time to Take Up Golf? 30,000 times per week 'no' to orgaandonorschap in registry Consumers want insight into price differences treatments 450 Dutch women have symptoms by sterilisatiebehandeling Ontlastingtest reduces the number of kijkonderzoeken at darmpatiënten Patient control over electronic file Medical research in children extended The elderly are more likely to get Lyme disease THAT doubles the recommended number of health visits during pregnancy A third vijftigplussers see the internet in case of physical complaints

Page d'accueil Publications PubMed Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. Jun 2013 Journal of cell science Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. Ghossoub R, Hu Q, Failler M, Rouyez MC, Spitzbarth B, Mostowy S, Wolfrum U, Saunier S, Cossart P, Jamesnelson W, Benmerah A Septins are a large, evolutionarily conserved family of GTPases that form hetero-oligomers and interact with the actin-based cytoskeleton and microtubules. They are involved in scaffolding functions, and form diffusion barriers in budding yeast, the sperm flagellum and the base of primary cilia of kidney epithelial cells. We investigated the role of septins in the primary cilium of retinal pigmented epithelial (RPE) cells, and found that SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9 and that the three members of this complex colocalize along the length of the axoneme. Similar to observations in kidney epithelial cells, depletion of cilium-localized septins by siRNA-based approaches inhibited ciliogenesis. MAP4, which is a binding partner of SEPT2 and controls the accessibility of septins to microtubules, was also localized to the axoneme where it appeared to negatively regulate ciliary length. Taken together, our data provide new insights into the functions and regulation of septins and MAP4 in the organization of the primary cilium and microtubule-based activities in cells.

Over the years 70 my farm has been recognized by ENCI with the name "Breeding of Nolano". My mastiffs are known and appreciated throughout the world. As President of the Society Amatori Neapolitan Mastiff, with my mastiffs i participated in the most important European exhibition with flattering results. Following a careful selection Breeding of Nolano produced and reared Champions of Beauty. E' vietata la riproduzione parziale e/o totale dei contenuti. Sito internet realizzato da Informix sw. hw.

Tune in to Learning Water: Science Lesson: Activity 1 of 3 Prev ActivityNext Activity DictionaryCalculator Search Dictionary.com for: Water can be solid, a liquid, or a gas. Solid, liquid, and gas are all states, or phases, of water. In its liquid phase, water takes the shape of its container, like a glass, a pail, or a swimming pool. In its solid phase, water has a definite shape, like an ice cube or an iceberg. When water is in its gaseous phase, it's invisible, as when a puddle evaporates and disappears into the air. Choose the correct phase of matter for water poured from a pitcher. IntroductionNext Website © 2014 Education Development Center, Inc. All rights reserved. Videos and Print Materials are available through a Creative Commons 4.0 Attribution Non-Commercial ShareAlike International License.

Welcome our new Dealer in the Vendor's Tents - Ben Stoeger's Pro Shop - Announcements - Brian Enos's Forums... Maku mozo! Please visit and welcome our new Dealer in the Vendor Tents - Ben Stoeger Pro Shop. Look forward to shopping with you, soon.

Zambon S.p.A., an international pharmaceutical company strongly committed to the central nervous system (CNS) therapeutic area, and its partner Newron Pharmaceuticals S.p.A. ("Newron") (SIX: NWRN), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain, today announced the availability of Xadago® (safinamide) in the United Kingdom. Andrew Lees, MD FRCP, FMedSci, Professor of Neurology, (The National Hospital for Neurology and Neurosurgery, Queen Square and Emeritus Director, Reta Lila, Weston Institute of Neurological Studies, University College London, Institute of Neurology) said: "After 10 years with no new drugs for Parkinson's disease I welcome the addition of another effective treatment option for patients". Maurizio Castorina, CEO of Zambon S.p.A. said: "We are committed to developing innovative therapies for patients suffering from PD and other central nervous system diseases. Xadago®offers PD patients a novel therapeutic option in the treatment of this progressive disease". The U.K is the latest country launching Xadago®, which is also available in seven other countries: Germany, Switzerland, Spain, Italy, Belgium, Denmark, and Sweden. Safinamide is a new chemical entity with a unique mode of action including selective and reversible MAO-B-inhibition and blocking of voltage dependent sodium channels which leads to modulation of abnormal glutamate release. Clinical trials have established its efficacy in controlling motor symptoms and motor complications in the short term, with data supporting this effect over 2 years. Results from 6 month double-blind controlled studies suggest that safinamide shows statistically significant effects on motor fluctuations (ON/OFF time) without increasing the risk of developing troublesome dyskinesia. Safinamide is a once-daily dose and has no diet restrictions. Zambon has the rights to develop and commercialize Xadago® globally, excluding Japan and other key territories where Meiji Seika has the rights to develop and commercialize the compound. The rights to develop and commercialize Xadago® in the USA have been granted to US WorldMeds, by Zambon. Newron (SIX: NWRN) is a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain. The Company is headquartered in Bresso near Milan, Italy. In addition to Xadago® for Parkinson's disease, Newron has a strong pipeline of promising treatments for rare disease patients at various stages of clinical development.

I'm Jonathan, and this is my little house on the Internet. Come on in and make yourself comfortable. First blog posts are a sort of genre of their own — a dreadfully dull genre, I'm afraid — wherein I introduce myself and state all of my plans and goals for the blog, before I (a) utterly neglect the blog, or (b) take it in a completely different direction. If you're reading this, I assume you probably already know me in real life; I'm not sure why else you would be here. But in case you don't, here's what you'll need to know to make sense of this: I'm a Christian (Presbyterian, to be specific, and PC(USA) to be even more specific), and I'm gay.

After 7 years of hard work by the Friends of Atherton Tablelands Rail Trail and the Tableland Regional Council, work will begin on removal of the rails and sleepers shortly and be completed by December 2013. It is hoped that the Mareeba Shire Council will continue this Trail at a later date. Construction on the first stage of this Rail Trail will start in early 2014 and be complete by mid 2014.

PARIS, Feb 6 (Reuters) - The French Senate on Wednesday voted in favour of allowing the state to lower its minority stake in gas and power group Engie, despite rejecting a proposal to privatise airport operator ADP earlier in the week. The French state owns 23.64 percent of Engie's capital and 34 percent of the shares' voting rights, and is required by law to keep at least 33 percent of the voting rights. Finance Minister Bruno Le Maire told the Senate that if Engie wanted to issue new capital to finance its expansion, the state would have no choice but to subscribe to respect the law. "That is why we ask for the possibility to lower the state's stake in Engie below the legal limit," Le Maire told senators. The government has given no indication of how much of its shares it may want to sell. The Senate, controlled by the conservative opposition, voted 250 against 92 in favour of the government proposal. A no-vote could only have delayed the operation, rather than definitively block it, since the Assemblee Nationale lower house of parliament - where President Emmanuel Macron's centrist LREM party has a comfortable majority - has the final vote. "The logic is the same for all government asset sales, we want to give (these companies) the chance to grow and develop," Le Maire said, adding that Engie would boost its investment in renewable energy, notably biogas and offshore wind power.

Focus Collections Upcoming Focus Issues Plant Cell Teaching Tools Follow plantphysiol on Twitter Visit plantphysiol on Facebook Research ArticleCELL BIOLOGY AND SIGNAL TRANSDUCTION Interaction of Calmodulin, a Sorting Nexin and Kinase-Associated Protein Phosphatase with the Brassica oleracea S Locus Receptor Kinase Vincent Vanoosthuyse, Gabrielle Tichtinsky, Christian Dumas, Thierry Gaude, J. Mark Cock Vincent Vanoosthuyse Gabrielle Tichtinsky Christian Dumas Thierry Gaude J. Mark Cock Published October 2003. DOI: https://doi.org/10.1104/pp.103.023846 Recognition of self-pollen during the self-incompatibility response in Brassica oleracea is mediated by the binding of a secreted peptide (the S locus cysteine-rich protein) to the S locus receptor kinase (SRK), a member of the plant receptor kinase (PRK) superfamily. Here, we describe the characterization of three proteins that interact with the cytosolic kinase domain of SRK. A B. oleracea homolog of Arabidopsis kinase-associated protein phosphatase was shown to interact with and dephosphorylate SRK and was itself phosphorylated by SRK. Yeast (Saccharomyces cerevisiae) two-hybrid screens identified two additional interactors, calmodulin and a sorting nexin, both of which have been implicated in receptor kinase down-regulation in animals. A calmodulin-binding site was identified in sub-domain VIa of the SRK kinase domain. The binding site is conserved and functional in several other members of the PRK family. The sorting nexin also interacted with diverse members of the PRK family, suggesting that all three of the interacting proteins described here may play a general role in signal transduction by this family of proteins. Plant genomes encode large numbers of receptors with Ser/Thr protein kinase activity. These plant receptor kinases (PRKs) are related to, but phylogenetically distinct from, the receptor Tyr kinase (RTK) and receptor Ser/Thr kinase (RSK) families in animals, suggesting that the three families have evolved independently from a common ancestor (Shiu and Bleecker, 2001). The independent evolution of these gene families is reflected in the fact that, to date, none of the proteins that have been shown to interact with PRKs are closely homologous to RTK- and RSK-interacting proteins. However, despite the many differences between plant and animal receptor kinase systems, there are indications that they function in a similar manner with, for example, unrelated interacting proteins carrying out analogous roles in the two kingdoms (Cock et al., 2002). One of the best characterized PRKs is the S locus receptor kinase (SRK). SRK is located in the plasma membrane of the stigmatic papillar cells and is the female component of the self-incompatibility (SI) response in Brassica spp. (Stein et al., 1991; Delorme et al., 1995; Takasaki et al., 2000). The SI response allows the recognition and rejection of self-pollen grains on the stigma surface and, hence, promotes outcrossing (Cock, 2000). There is now strong evidence that SRK mediates self-pollen recognition by binding to a small, secreted peptide, S locus Cys rich (SCR), located in the pollen coat (Schopfer et al., 1999; Takayama et al., 2000, 2001; Shiba et al., 2001; Kachroo et al., 2001). SRK is phosphorylated after an incompatible pollination (Cabrillac et al., 2001), and in vitro experiments indicate that activation of SRK may involve autophosphorylation between SRK molecules associated in the membrane (Giranton et al., 2000). This suggests that SRK is activated by a mechanism similar to that described for animal receptor kinases (Heldin, 1995). The signal transduction pathway downstream of SRK has been partially characterized. ARC1 (arm repeat containing 1; a complex protein with multiple domains including a Leu zipper, a U box, and a C-terminal Arm repeat domain; accession no. AJ427335) interacts with the SRK kinase domain and is required for efficient rejection of self-pollen (Gu et al., 1998; Stone et al., 1999). ARC1, which has E3 ubiquitin ligase activity, is thought to mediate pollen rejection by promoting the ubiquitination of compatibility factors in the pistil (Stone et al., 2003). There are also indications that negative control of SRK signaling may play a role in SI signaling, both in the basal state, before pollination, and after SRK activation. SRK interacts with two thioredoxin h-like proteins (THL1 and THL2; Bower et al., 1996). THL1 inhibits constitutive autophosphorylation of SRK in the absence of ligand (Cabrillac et al., 2001), and its interaction with SRK requires the presence of a conserved Cys residue on the cytoplasmic side of the SRK transmembrane domain (Mazzurco et al., 2001). Therefore, THL1 appears to act as a basal state inhibitor, in a manner analogous to FKBP12, which binds to and prevents activation of transforming growth factor β receptor II (Wang et al., 1996). SRK also interacts, in vitro, with Arabidopsis kinase-associated protein phosphatase (KAPP; accession no. AJ427336; Braun et al., 1997). KAPP interacts with many other PRKs (Braun et al., 1997; Williams et al., 1997; Stone et al., 1998; van der Knaap et al., 1999; Gomez-Gomez et al., 2001); for example, KAPP is phosphorylated by CLV1 (CLAVATA1) and dephosphorylates the kinase domain of this receptor in vitro (Williams et al., 1997; Stone et al., 1998). Experiments in which KAPP expression has been manipulated in transgenic plants indicate that KAPP is a negative regulator of both CLV1 and FLS2, and it has been proposed that KAPP has a general role in the down-regulation of a large spectrum of PRKs (Williams et al., 1997; Stone et al., 1998; Gomez-Gomez et al., 2001). Endocytosis is known to occur in plants (Emans et al., 2002), and KAPP may also have an important role in regulating PRK internalization. When the PRK AtSERK1 was transiently co-expressed with KAPP, the former was sequestered in intracellular vesicles (Shah et al., 2002). Down-regulation and internalization by endocytosis are essential for correct regulation of receptor kinases in animals, and a wide range of mechanisms have been described, including inhibitors acting on receptors in their basal state; regulation by dephosphorylation, by phosphorylation, or by calmodulin binding; Cbl-mediated receptor ubiquitylation; and sorting nexin-mediated targeting to endosomes (San José et al., 1992; Kurten et al., 1996; Wang et al., 1996; Martín-Nieto and Villalobo, 1998; Feinmesser et al., 1999; Carraway III and Sweeney, 2001; Östman and Böhmer, 2001). Moreover, individual receptors may be regulated by several of these processes. We show here that SRK interacts with and is dephosphorylated by the Brassica homolog of KAPP, indicating that this protein plays a role in SRK down-regulation. SRK was also shown to interact with calmodulin and a sorting nexin, both of which are proteins that have been implicated in receptor kinase down-regulation in animals. KAPP, calmodulin, and the sorting nexin also interact with additional, diverse PRKs. The possible roles of these three proteins in PRK down-regulation and endocytosis are discussed. SRK Interacts with a Brassica oleracea Homolog of KAPP The demonstration that the Arabidopsis KAPP protein interacts with SRK in vitro (Braun et al., 1997) suggested that a similar interaction may occur in stigmas between SRK and a Brassica homolog of KAPP. A B. oleracea KAPP homolog was isolated from a stigma cDNA library and shown to share 80.1% similarity overall with Arabidopsis KAPP at the amino acid level. Interaction between Arabidopsis KAPP and PRKs is mediated by a forkhead-associated (FHA) domain (Li et al., 1999). The Brassica KAPP FHA domain is highly similar to that of Arabidopsis KAPP, including the presence of four highly conserved residues that are required for binding to phosphoproteins (Fig. 1A). Interaction of the Brassica KAPP and SRK proteins. A, Alignment of the FHA domains from the Brassica (Bo KAPP) and Arabidopsis (At KAPP) KAPP proteins and yeast (Saccharomyces cerevisiae) RAD53 (Sc RAD53). Arrowheads indicate residues required for binding of Arabidopsis KAPP to PRKs (Li et al., 1999). B, Kinase interaction (KI) domain of Brassica KAPP and the C-terminal end of ARC1 (containing the Arm repeats) interact with the wild type but not with a kinase-inactive form of the SRK29 kinase domain in the yeast two-hybrid assay. Different numbers of yeast strain PJ69-4A cells expressing the prey and bait indicated above and below the panel, respectively, were inoculated by spotting onto selective medium lacking His and adenine and grown at 30°C for 5 d. C, Phosphorylation of Brassica KAPP by SRK. Glutathione S-transferase (GST) fusion proteins with Brassica KAPP or with either wild-type or mutant forms of the SRK29 kinase domain were mixed in phosphorylation reactions as indicated. The KAPP and SRK fusion proteins are indicated by arrowheads. Proteins were detected by autoradiography (top) or by immunoblotting with an anti-GST antibody (bottom). Note that the active form of the SRK29 kinase domain was detected as a diffuse band (indicated by a bar). Phosphatase treatment showed that this was due to the presence of differentially phosphorylated isoforms (data not shown). D, Dephosphorylation of SRK by KAPP. Radiolabeled, phosphorylated GST::SRK29kin was incubated in the presence or absence of GST::KAPP, and the proteins were separated on an SDS-PAGE gel. Radiolabeled GST::SRK29kin was detected by autoradiography (top) and total GST::SRK29kin protein was detected with an anti-GST antibody (bottom). We used the yeast two-hybrid system to test whether Brassica KAPP interacts with the kinase domain of SRK. The KI domain of Brassica KAPP was expressed as a fusion protein with the activation domain of Gal4 (Gal4AD::KI) in yeast cells that also expressed the kinase domain of SRK29 fused to the DNA-binding domain of Gal4 (Gal4DB::SRK29kin). As a positive control for this experiment, we tested whether the kinase domain of SRK interacted with ARC1 in this system. For this, we cloned the Arm-repeat region of a B. oleracea homolog of ARC1 (residues 362–661) and expressed it as a fusion protein with Gal4 (Gal4AD::ARC) in the same kinase domain-expressing yeast strain. ARC1 has been shown to interact with SRK in closely related B. napus (Gu et al., 1998). Both combinations of interactors were able to induce all three reporter genes in the PJ69-4A strain (James et al., 1996), leading to His and adenine prototrophy (Fig. 1B) and production of α-galactosidase enzyme activity (data not shown). In contrast, neither the KAPP nor the ARC1 fusion proteins interacted with an enzymatically inactive, mutant form of the SRK29 kinase domain (Gal4DB::SRK29kinK561R; Fig. 1B). These observations corroborate previous studies that have shown that ARC1 and Arabidopsis KAPP interact only with the phosphorylated form of the SRK kinase domain (Braun et al., 1997; Gu et al., 1998). To test whether KAPP could be phosphorylated by SRK, a fusion protein consisting of GST fused to Brassica KAPP lacking its predicted N-terminal signal anchor (residues 1–47) was expressed in Escherichia coli, and the purified protein (GST::KAPP) was added to a phosphorylation reaction in the presence of either the wild type or a mutant form of the SRK29 kinase domain that had also been expressed in E. coli as protein fusions with GST (GST::SRK29kin and GST::SRK29kinK561R). KAPP was phosphorylated by the wild-type SRK29 kinase but not by the kinase-negative mutant form (Fig. 1C). A phosphorylation assay confirmed that the wild-type kinase domain construct, GST::SRK29kin, was capable of autophosphorylation in vitro, whereas the mutant form, GST::SRK29kinK561R, was enzymatically inactive (data not shown). Furthermore, Figure 1D shows that when GST::KAPP was added to radiolabeled, phosphorylated GST::SRK29kin in vitro, the latter was dephosphorylated, indicating that SRK is a substrate for the phosphatase activity of KAPP. Identification of Novel SRK-Interacting Proteins Using the Yeast Two-Hybrid System The above experiments showed that the kinase domain of SRK29 was able to interact specifically with KAPP and ARC1 in the two-hybrid assay. Based on this result, we initiated a screen to identify novel interacting partners using the two-hybrid system. Several two-hybrid screens were performed, using both wild-type (Gal4DB::SRK29kin) and mutant (Gal4DB::SRK29kinK561R) forms of the SRK kinase domain and the kinase domain of SFR1 (Gal4DB::SFR1kin), a receptor closely related to SRK that is also expressed in stigmas (Pastuglia et al., 2002). After each screen, potential interactors were co-expressed with a fusion between murine p53 (residues 72–390) and the Gal4 DNA-binding domain (Gal4DB::p53) to eliminate nonspecific interactions. Four novel interactors were identified in these screens, the most interesting being calmodulin and a Brassica SNX1 (sorting nexin 1; accession no. AJ441072) homolog (Table I). Calmodulin cDNAs were recovered in screens with all three bait proteins, and the interaction was confirmed in a second yeast strain, Y190, using both wild-type and mutant SRK kinase domain constructs (data not shown). Table I. Interaction of ARC1, KAPP, and calmodulin with the kinase domains of SRK and SFR1 in the yeast two-hybrid system The calmodulin cDNAs identified in the three screens corresponded to two different genes (designated Calmodulin 1, accession no. AJ427337; and Calmodulin 2, accession no. AJ427338) that differed significantly in their 3′ non-translated regions. However, the coding regions of these two calmodulin genes are 93.2% identical, and they encode identical proteins. The deduced amino acid sequence of the Brassica calmodulins is 98.0% identical to that of a previously described B. napus calmodulin (accession no. AF150059). SRK Interacts with Calmodulin in Vitro Calmodulin-Sepharose affinity binding was carried out to confirm the interaction between calmodulin and the kinase domain of SRK. Figure 2A shows that fusion proteins consisting of GST plus either the wild type or a mutant form of the SRK29 kinase domain bound to calmodulin-Sepharose beads in the presence of 5 mm CaCl2 and were eluted from the beads when the 5 mm CaCl2 was replaced by 5 mm EGTA. When GST alone was loaded on the column, some protein bound to the beads, but this was removed by washing with 5 mm CaCl2 and was not specifically eluted by 5 mm EGTA. Calmodulin binds to the kinase domain of SRK in vitro. A, Binding of GST or the GST protein fused with either wild-type or mutant forms of the SRK29 kinase domain to calmodulin-Sepharose beads. GST-containing proteins were detected with an anti-GST antibody. B, Binding of the integral SRK protein to calmodulin-Sepharose beads. A recombinant hexa-His epitope-tagged, kinase-inactive form of SRK (mSRK3His; Giranton et al., 2000) was used for this experiment. SRK protein was detected with the monoclonal antibody MAb85-36-71 (Giranton et al., 2000). C, Binding of Brassica calmodulin to glutathione-Sepharose beads carrying either GST or GST protein fused to either wild-type or mutant forms of the SRK29 kinase domain. Eluted proteins were detected by silver staining. Note that calmodulin alters its conformation in the presence of calcium resulting in a change in mobility. CAM, Calmodulin with no bound Ca2+; CAM/Ca, calmodulin with bound Ca2+; C, purified fusion protein; UB, unbound fraction; W1 and W40, washes; E1 to E4, eluted fractions. C and UB, One-quarter of the amount of protein loaded on and unbound to the column, respectively. Similarly, when a kinase-negative, hexa-His epitope-tagged form of the integral SRK3 protein (mSRK3His) expressed in insect cells was subjected to calmodulin-Sepharose affinity binding, the recombinant protein bound to the calmodulin-Sepharose beads and was eluted in the presence of 5 mm EGTA (Fig. 2B). The interaction between the kinase domain of SRK and calmodulin was also confirmed using an alternative affinity-binding approach. GST alone or fused to either the wild type or the mutant form of the SRK29 kinase domain was bound to glutathione-Sepharose beads. Brassica calmodulin 2 tagged with a hexa-His epitope was then expressed in insect cells, affinity purified on nickel-nitrilotriacetic acid agarose beads, and applied to beads carrying the SRK fusion proteins in the presence of calcium. After washing, calmodulin was specifically eluted from the beads in the presence of 5 mm EGTA. Figure 2C shows that calmodulin bound to beads carrying both wild-type and mutant kinase domain protein fusions but not to beads carrying GST alone. Calmodulin Interacts with an Amphiphilic Helix in Sub-Domain VIa of the SRK Kinase Domain Calmodulin has been shown to interact with its target proteins by binding to small amphiphilic α-helices (Erickson-Viitanen and DeGrado, 1987). To identify the region of SRK responsible for the interaction with calmodulin, we searched for small amphiphilic α-helices in the SRK kinase domain using multiple secondary structure prediction programs. Two small potential helices were found in subdomains VIa and VII (for a definition of the kinase sub-domains, see Hanks et al., 1988). Comparison of all the SRK alleles available in the databases showed that all of the deduced proteins were predicted to possess an amphiphilic helix at the same position in sub-domain VIa. Therefore, this region, designated HEL1, was selected for further study. The HEL1 region of the SRK3 protein (amino acids 617–643 of SRK3) is shown in Figure 3A as a helical projection. The amphiphilic nature of this region is indicated by the black bar. Calmodulin binds to sub-domain VIa of the kinase domain of SRK in vitro. A, Amino acid sequence of the HEL1 region of sub-domain VIa of SRK3. The wheel projection shows the amphiphilic nature of HEL1. The sequence of the control peptide PEP1 is also shown. B, Binding of GST::HEL1 and GST::PEP1 fusion proteins to calmodulin-Sepharose beads. GST-containing proteins were detected with an anti-GST antibody. C, purified GST fusion protein; UB, unbound fraction; W1 and W40, first and last washes; E1 to E4, eluted fractions. Figure 3B shows that, when the HEL1 peptide was fused to GST (GST::HEL1), the fusion protein bound to calmodulin-Sepharose beads and was eluted in the presence of 5 mm EGTA, indicating that HEL1 interacts specifically with calmodulin. GST fused to a non-helical, nonamphiphilic peptide of the same size as, and of similar hydrophilicity to, HEL1 (PEP1 in Fig. 3A) did not bind to calmodulin-Sepharose beads (Fig. 3B). Calmodulin Interacts with the Kinase Domains of a Wide Range of PRKs The fact that calmodulin interacted with the kinase domains of both SRK and SFR1 in the yeast two-hybrid assay (Table I) indicated that this interaction was not specific to SRK and suggested that calmodulin may interact with other receptor kinases. To test this, we expressed both wild-type and mutant forms of the SFR1 kinase domain and wild-type kinase domains of three additional members of the PRK superfamily, RLK4 (receptor-like kinase 4), CLV1, and BRI1 (brassinosteroid insensitive 1) as fusion proteins with either GST or the maltose-binding protein (MBP). RLK4 is a member of the S gene family of receptor kinases but is distantly related to SRK (approximately 25% amino acid identity depending on the allele of SRK); CLV1 and BRI1 are members of the family of PRKs that contain Leu-rich repeats in their extracellular domains. All five of the recombinant proteins were then purified and subjected to a calmodulin affinity-binding assay. Figure 4A shows that all the proteins tested, apart from GST::BRI1kin, bound to the calmodulin-Sepharose beads in the presence of 5 mm CaCl2 and were eluted after addition of 5 mm EGTA. Analysis of the sub-domain VIa regions of these proteins showed that all except BRI1 were predicted to include amphiphilic helices. Therefore, the presence of a predicted amphiphilic helix in kinase sub-domain VIa was correlated with the ability to bind calmodulin. Calmodulin binds to the kinase domains of SFR1, RLK4, and CLV1, but not BRI1, in vitro. A, Analysis of the binding of the kinase domains of SFR1, RLK4, CLV1, and BRI1 to calmodulin-Sepharose. The kinase domains were expressed as fusion proteins with either GST or MBP. Both a wild-type (GST::SFR1kin) and a kinase-inactive mutant form (GST::SFR1kinK555R) of the SFR1 kinase domain were tested. GST- and MBP-containing proteins were detected with anti-GST and anti-MBP antibodies, respectively. B, Abundance of calmodulin transcripts in different Brassica organs. Calmodulin transcripts were detected with a probe corresponding to the entire coding sequence. Lower, Ethidium bromide-stained rRNA. The positions of RNA size markers are shown at right in kilobase pairs. R, Root; C, cotyledon; L, leaf; Se, sepal; P, petal; A, anther; O, ovary; St, stigma. Interestingly, we consistently observed that MBP::RLK4kin was eluted from the calmodulin-Sepharose beads in two peaks, indicating the presence of more than one calmodulin-binding site in the RLK4 kinase domain, the sites having different binding affinities. The expression pattern of calmodulin was consistent with it interacting with multiple PRKs expressed in different parts of the plant because transcripts were detected in a wide range of organs (Fig. 4B). Calmodulin and SRK Autophosphorylation We were interested in determining whether calmodulin binding modified SRK autophosphorylation because HEL1 is located close to the activation loop in the kinase domain of SRK. In a kinase assay carried out in vitro, addition of calmodulin in the presence of 5 mm CaCl2 did not prevent autophosphorylation of GST::SRK29kin, and calmodulin was not phosphorylated by the kinase domain fusion protein (data not shown). The same result was obtained when the experiment was repeated with full-length SRK protein that had been expressed in insect cells (data not shown). This result suggests that calmodulin binding has no direct effect on SRK kinase activity. Again, calmodulin was not phosphorylated in these reactions, indicating that it is not a substrate of SRK kinase activity. Interaction of SRK with a Sorting Nexin Sorting nexins have been implicated in cargo trafficking through the endosomal system in mammals and yeast, and several members of this family interact with animal receptor kinases (Kurten et al., 1996; Haft et al., 1998; Parks et al., 2001; Teasdale et al., 2001). Therefore, we were particularly interested when a Brassica sorting nexin homolog (Brassica SNX1) was isolated as an interactor with the mutant form of the SRK29 kinase domain in the yeast two-hybrid screen (Table I). Sequence analysis showed that Brassica SNX1 was most similar to an SNX1 homolog from Arabidopsis but also shared extensive similarity with human (Homo sapiens) SNX1 (Fig. 5A). Human SNX1 contains a PX domain plus three predicted coiled-coil domains in the C-terminal part of the protein. Comparison of the PX domains of sorting nexins has allowed the identification of three highly conserved motifs, two of which (RRY/FSD/EFxxLxxxL and RR/KxxLxxY/F where x is any amino acid) are predicted to form a basic pocket involved in phosphoinositol binding and a third, Pro-rich motif (PPxPxK), which may be involved in protein-protein interactions (Sato et al., 2001; Xu et al., 2001). All three of these motifs are present in Brassica SNX1. Moreover, the COILS algorithm (Lupas, 1996) predicts a coiled-coil domain between residues 320 and 370 of Brassica SNX1, and the BLAST algorithm (Altschul et al., 1990) is able to match this region to human SNX1 in database searches (Fig. 5A). Hence, there are extensive similarities between human SNX1 and Brassica SNX1, suggesting that these two proteins carry out similar functions. Sequence analysis of Brassica SNX1 and the sorting nexin family in Arabidopsis. A, Alignment of Brassica SNX1 (Bo SNX1) with Arabidopsis (At SNX1) and human (Hs SNX1) SNX1. Residues conserved in at least two proteins are shaded. The phox homology (PX) and coiled-coil domains of Brassica SNX1 are overlined with a continuous and a dotted line, respectively. B, Neighbor-joining tree based on an alignment of the PX domains of Brassica SNX1 and of the Arabidopsis, human, and yeast sorting nexin families. The tree was constructed using the PAM250 amino acid substitution matrix. Numbers next to the branches are bootstrap values expressed as percentage confidence level and based on 1,000 repeats. The PX domain of human PI-3 kinase was used to root the tree. The PX domain polypeptide sequences compared were Brassica SNX1, Arabidopsis SNX1 (At SNX1; accession no. At5g06140), SNX2a (At SNX2a; At5g58440), and SNX2b (At SNX2b; At5g07120), several human (Hs SNX1, Q13596; Hs SNX2, O60749; Hs SNX3, O60493; Hs SNX4, O95219; Hs SNX5, Q9Y5X3; Hs SNX6, Q9UNH7; Hs SNX7, Q9UNH6; Hs SNX8, Q9Y5X2; Hs SNX9, Q9Y5X1; Hs SNX10, Q9Y5X0; Hs SNX11, Q9Y5W9; Hs SNX12, Q9UMY4; Hs SNX15, Q9NRS6), and yeast (Sc YJL036W, S56808; Sc Vps17p, NP_014775; Sc Mvp1p, P40959; Sc Grd19p, Q08826; Sc Vps5p, Q92331; Sc YJL113C, CAA98681; Sc YDR425W, S69707; Sc YHR105W, S48947; Sc Vam7p, P32912) sorting nexins and human PI-3 kinase (Hs PI-3 kinase, JC5500). The domain architecture of the sorting nexins is shown at right. Gray boxes, PX domains; white circles, coiled-coil domains. Both the human and yeast genomes contain moderately large families of sorting nexins (Teasdale et al., 2001; Xu et al., 2001), but only three genes in the Arabidopsis genome have been annotated as sorting nexins. We extensively screened the Arabidopsis genome with all the available human and yeast sorting nexin sequences using the tBLASTn algorithm but did not identify any additional homologs. Therefore, the sorting nexin family in Arabidopsis is smaller and less diverse than in humans or in yeast (Fig. 5B). To confirm the interaction between SRK and Brassica SNX1, GST alone or GST fused to wild-type or kinase-negative forms of the SRK29 kinase domain were bound to glutathione-Sepharose beads and then incubated with hexa-His-tagged SNX1. Kinase/SNX1 complexes were then eluted from the resin by addition of glutathione. Figure 6A shows that SNX1 was eluted from the resin only if kinase domain fusion proteins were present as bait. No SNX1 was detected in the glutathione elution fractions if the bait used was GST protein alone. Deletion analysis demonstrated that the PX domain of Brassica SNX1 was sufficient to mediate the interaction with SRK (Fig. 6B). Brassica SNX1 binds to the kinase domains of SRK, SFR1, and CLV1 in vitro. A, Elution of SNX1 from affinity resins loaded with GST or MBP proteins alone or GST or MBP fused with the kinase domains of SRK29, SFR1, or CLV1. Both wild-type and kinase-inactive mutant forms of the SRK29, SFR1, and CLV1 kinase domains were tested. B, Interaction between the SRK kinase domain and the PX domain (amino acids 1–157) of Brassica SNX1. Hexa-His-tagged SNX1 was detected with an anti-HIS antibody. In some cases, multiple bands were detected presumably due to the presence of either breakdown products or incompletely synthesized recombinant SNX1. E1 and E2, Eluted fractions. SRK29kin, GST::SRK29kin; SRK29kinK561R, GST::SRK29kinK561R; SFR1kin, GST::SFR1kin; SFR1kinK555R, GST::SFR1kinK555R; CLV1kin MBP::CLV1kin; CLV1kinK720E, MBP::CLV1kinK720E. C, RT-PCR analysis of SNX1 expression. Calmodulin (CAM) and actin cDNA were also amplified as controls. R, Root; C, cotyledon; L, leaf; Se, sepal; P, petal; A, anther; O, ovary; St, stigma; –, no cDNA control. Using the same approach, we were also able to demonstrate interactions between SNX1 and two other PRK kinase domains, from SFR1 and CLV1 (Fig. 6A). SNX1 interacted with both wild-type and kinase-negative forms of the SRK kinase domain, but this was not the case for SFR1 and CLV1 where only the wild-type or only the kinase negative forms interacted, respectively. It is not clear why such differences were observed, but the differences were clearly reproducible. The interaction of SNX1 with the kinase domains of three diverse receptors suggests that this protein may play a role in multiple PRK signal transduction pathways. This hypothesis is supported by the fact that SNX1 transcripts were detected in a wide range of Brassica organs (Fig. 6C). In this study, we have investigated interactions between several cytoplasmic stigma proteins and the kinase domain of SRK. We show that a stigma-expressed Brassica homolog of KAPP interacts with, and is phosphorylated by, the kinase domain of SRK in vitro. KAPP was also shown to dephosphorylate SRK. These results, together with the observation that SRK is phosphorylated in vivo approximately 1 h after an incompatible pollination (Cabrillac et al., 2001), suggest that KAPP may play a role in SRK down-regulation, as has been proposed for CLV1 and FLS2 (Williams et al., 1997; Stone et al., 1998; Gomez-Gomez et al., 2001). KAPP may not be the only protein phosphatase involved in the SI response because a breakdown of SI has been observed in pistils after treatment with okadaic acid or microcystin LR (Rundle et al., 1993; Scutt et al., 1993). Note, however, that okadaic acid and microcystin LR are inhibitors of type 1 and type 2A phosphatases and would not be expected to inhibit type 2C phosphatases such as KAPP. Four previously unidentified interacting proteins were recovered by a two-hybrid screen carried out to search for new SRK-interacting proteins. One of these interactors, calmodulin, was of interest because it is known to be a component of many signal transduction pathways in both plants and animals (Sanders et al., 1999; Chin and Means, 2000). Calmodulin has been shown to interact with two animal receptor kinases: the epidermal growth factor receptor (EGFR) and the insulin receptor (Graves et al., 1985; San José et al., 1992; Joyal et al., 1996; Martín-Nieto and Villalobo, 1998; Feinmesser et al., 1999). However, the role of these interactions is not yet clear. Autophosphorylation of purified rat (Rattus norvegius) liver EGFR was inhibited by calmodulin in vitro, suggesting a direct role for calmodulin in down-regulation of the EGFR (San José et al., 1992). In contrast, the kinase activity of human EGFR, overexpressed in murine fibroblasts, was not inhibited by calmodulin binding (Martín-Nieto and Villalobo, 1998). However, binding of calmodulin may also have more subtle effects because it is known to regulate intracellular trafficking of EGFR (Tebar et al., 2002), and this regulation is thought to be mediated, at least in part, by its antagonistic effect on phosphorylation of EGFR by protein kinase C. Calcium fluxes have been measured in both the cytoplasm and in the cell wall of stigmatic papillar cells after both compatible and incompatible pollination (Dearnaley et al., 1997; Elleman and Dickinson, 1999). These fluxes are associated with the region of the cell that contacts the pollen grain, and small, localized peaks in cytoplasmic calcium concentration have been correlated with subsequent hydration of pollen grains in B. napus (Dearnaley et al., 1997; Goring, 2000). Therefore, a possible role of calmodulin in vivo might be to mediate cross talk between calcium signaling occurring during pollination and SI signal transduction. In addition to SRK, calmodulin interacted in a calcium-dependent manner with the kinase domains of three distantly related PRKs (SFR1, RLK4, and CLV1) but not with the kinase domain of BRI1. This suggests that calmodulin may interact with a broad range of PRKs. A short region from within sub-domain VIa of the SRK kinase domain resembled a calmodulin-binding site based on its predicted amphiphilic α-helical structure, and this region was shown to bind calmodulin when fused to the C terminus of GST. Amphiphilic helices are predicted to occur in the subdomain VIa regions of SFR1, RLK4, and CLV1 but not BRI1, indicating a correlation between the presence of an amphiphilic helix and the ability to bind calmodulin. Sub-domain VIa is located close to the predicted ATP-binding site and the activation loop of the kinase domain, and this region is thought to play a structural role in PRKs (Torii and Clark, 2000). Interestingly, in the Arabidopsis Landsberg erecta mutant, a highly conserved hydrophobic residue (Ile-750) in sub-domain VIa of the ERECTA receptor kinase is replaced by a positively charged Lys residue (Torii et al., 1996). Secondary structure predictions indicate that ERECTA, like SRK, possesses an amphiphilic helix in this region of the kinase domain (even if the helix is less clearly predicted than that of SRK) and the replacement of Ile-750 by a Lys is predicted to modify the amphiphilicity of this putative helix. It would be interesting to determine whether this mutation affects binding to calmodulin. The interaction observed between SRK and Brassica SNX1 is of particular interest because sorting nexins have been implicated in the down-regulation of animal receptor kinases. Several members of the sorting nexin family have been shown to interact with RTKs or RSKs both in vitro and in vivo (Kurten et al., 1996; Haft et al., 1998; Chin et al., 2001; Parks et al., 2001; Phillips et al., 2001) and modification of the rates of internalization and degradation of the EGFR and the platelet-derived growth factor receptor have been observed after overexpression of sorting nexins (Kurten et al., 1996; Phillips et al., 2001). In yeast, the SNX1 homolog Vps5p/Grd2p is part of the retromer complex that is essential for retrograde transport from the endosome to the Golgi (Seaman et al., 1998). In addition to Vps5p, the retromer complex includes Vps26p, Vps29p, Vps35p, and Vps17p, and human orthologs of the first three of these proteins have been shown to form a complex that includes SNX1 (Haft et al., 2000). Moreover, human SNX1 reversibly associates with a specific endosomal compartment, again indicating a role in protein trafficking (Kurten et al., 1996, 2001; Teasdale et al., 2001). Apart from the PX domain, no other sequences are widely conserved in sorting nexins (Teasdale et al., 2001). It is, therefore, significant that the similarity between the Brassica and human SNX1 proteins extends outside the PX domain, indicating that the two proteins carry out a similar function. Interestingly, the Arabidopsis genome is also predicted to encode orthologs of the retromer complex proteins Vps26p (accession no. Q9T091), Vps29p (CAB41864), and Vps35p (NM_127333). Plants, therefore, potentially possess all the components of a sorting nexin-based, vesicle trafficking system. It is possible that KAPP, which plays an important role in the internalization of AtSERK1 (Shah et al., 2002), interacts functionally with such a system to mediate PRK endocytosis. In contrast to previous studies, which have indicated that plant and animal receptor kinases interact with structurally distinct sets of cytoplasmic proteins (Bower et al., 1996; Gu et al., 1998; Stone et al., 1998; Trotochaud et al., 1999; Schlessinger, 2000), we show here that SRK interacts with two proteins, calmodulin and SNX1, that are closely homologous to animal receptor kinase interactors. It has been proposed that the evolution of membrane-spanning receptor kinases occurred independently in plants and animals, perhaps coinciding with the evolution of multicellularity (Shiu and Bleecker, 2001; Cock et al., 2002). If this was the case, then the interactions with calmodulin and SNX1 in plants and animals were either acquired by convergent evolution, or these proteins already interacted with the common ancestor of plant and animal receptor kinases, which is thought to have been cytosolic (Shiu and Bleecker, 2001). Further analysis of the function of calmodulin and SNX1 in the regulation of receptor kinases in these two kingdoms should help distinguish between these two possibilities. Cloning the Brassica oleracea Homolog of KAPP An internal fragment of the Brassica KAPP coding sequence was amplified from a stigma cDNA library in the yeast (Saccharomyces cerevisiae) two-hybrid vector, pAD-Gal4 2.1 (see below), using two oligonucleotides, Kap1 (5′-GGAGGGATCCCAAGTTGGCTGTTCCTGGAAGTCAT-3′) and Kap2 (5′-CGCTGGATCCGGAAGTTTCCTGCCTCCTCGACGCAT-3′), based on the Arabidopsis KAPP gene sequence. Overlapping fragments corresponding to the 5′ and 3′ ends of the KAPP cDNA were then amplified using the two above oligonucleotides and two additional Brassica KAPP oligonucleotides, Kap3 (5′-TGGGCTTCAATTTGCTGTTCACTCC-3′) and Kap4 (5′-GGGATCTGAGGCCACACCAACT-3′), in combination with vector oligonucleotides from a second stigma cDNA library (Giranton et al., 1995) using a nested PCR amplification approach. Multiple cloned PCR fragments were sequenced to obtain the final definitive cDNA sequence. cDNA Library Construction and Yeast Two-Hybrid Experiments Total RNA was extracted, using the method described by Cock et al. (1997), from 600 stigmas of a B. oleracea line homozygous for the S3 SI haplotype (Delorme et al., 1995). A cDNA library was constructed from poly(A+) RNA in the HybriZAP vector (Stratagene, La Jolla, CA). Gene fusions of KAPP and ARC1 sequences with the Gal4 activation domain (Gal4AD) were constructed in pACT2 (CLONTECH, Palo Alto, CA). All gene fusions with the Gal4 DNA-binding domain (Gal4DB), including the kinase domains of SRK29 (amino acids 469–854; accession nos. T14519, 30) and SFR1 (amino acids 469–850; accession nos. T14519, 31), the KI domain of Brassica KAPP (amino acids 110–314), and the C-terminal domain of Brassica ARC1 (amino acids 36–661), were constructed in pAS2 (CLONTECH). Mutant kinase domains lacking kinase activity (SRK29K561R and SFR1K555R) were prepared with the Quickchange express kit (Stratagene). For two-hybrid assays, yeast strains PJ69-4A (James et al., 1996) and Y190 (Flick and Johnston, 1990) were cotransformed using a lithium acetate-based protocol (Gietz et al., 1992) and grown on standard media (Anonymous, 2001). Protein Expression and Purification Gene fusions of the wild-type and mutant kinase domains of SRK29 and SFR1 with GST were constructed (Mazzurco et al., 2001; this work) in pGEX vectors (Pharmacia Corporation, North Peapack, NJ). The kinase domains of RLK4, BRI1, CLV1, and a kinase-negative form of CLV1 were expressed in Escherichia coli as fusion proteins with either MBP (for RLK4 and CLV1) or with GST (for BRI1). The fusion protein GST::KAPP included full-length Brassica KAPP without its signal peptide. GST::HEL1 included a fragment of sub-domain VIa of the SRK3 kinase domain (codons 617–643). A similar fusion protein carrying a non-helical, nonamphiphilic peptide of the same size and of similar hydrophilicity was called GST::PEP1. Expression of GST fusion proteins in E. coli and purification on a glutathione-Sepharose column were as described (Mazzurco et al., 2001), except for GST::SRK29K561R, which was grown at 20°C. Hexa-His-tagged Brassica SNX1 and its deleted form (codons 1–157 including the PX domain) were constructed in pQE32 (Qiagen S.A., Courtaboeuf, France) and expressed as described (Channelière et al., 2002). Recombinant baculovirus containing the hexa-His-tagged Brassica calmodulin 2 was obtained with the Bac-to-Bac baculovirus expression system (Invitrogen, Carlsbad, CA). Hexa-His-tagged wild-type and kinase-negative forms of the mSRK3 (SRK3His and SRK3His) and Brassica calmodulin 2 were expressed in insect cells as described (Giranton et al., 2000). Calmodulin 2 was purified on nickel-nitrilotriacetic acid agarose beads (Qiagen S.A.). Purified GST::kinase fusion proteins (2 μg in 300 μL) were incubated in 50 mm HEPES (pH 7.4), 150 mm NaCl, 1 mm dithiothreitol (DTT), 5 mm CaCl2, and antiprotease cocktail (Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany) with 100 μL of calmodulin-agarose resin (Sigma, St. Louis) for 1 h at 4°C in Eppendorf tubes with gentle agitation. The resin was washed with 40 column volumes of the binding buffer, and proteins eluted in 50 mm HEPES (pH 7.4), 150 mm NaCl, 1 mm DTT, 5 mm EGTA, and antiprotease cocktail were detected by immunoblotting using an anti-GST antibody (Pharmacia Corporation). Before carrying out the calmodulin-binding assay, mSRK3His expressed in insect cells was solubilized in 62.5 mm Tris-HCl (pH 6.8), 2.5% (w/v) SDS, 0.13 m DTT, and 20% (w/v) glycerol by heating at 100°C for 10 min and desalted twice on Bio-Gel P6-DG columns (Bio-Rad, Hercules, CA). For kinase domain affinity-binding assays, 1 μg of GST::SRK29kin or GST::SRK29kinK561R was bound to glutathione-Sepharose beads (100 μL) and then incubated with 2 μg of Brassica calmodulin. Washing and elution were as above, and proteins were detected on silver-stained SDS-PAGE gels. Binding to SNX1 was detected by incubating E. coli extracts containing equivalent amounts of soluble, recombinant GST- or MBP-kinase domain fusion proteins in affinity lysis buffer (50 mm HEPES [pH 7.4], 150 mm NaCl, 10 mm EDTA, 1 mm DTT, and antiprotease cocktail) with 25 μL of glutathione-Sepharose (Amersham Pharmacia Biotech Inc., Piscataway, NJ) or amylose-Sepharose resin (New England BioLabs, Beverly, MA), respectively. The resin was washed once with affinity wash buffer (50 mm HEPES [pH 7.4], 150 mm NaCl, 10 mm EDTA, and 1 mm DTT) and then incubated with E. coli extracts containing recombinant hexa-His-nexin fusion proteins in affinity lysis buffer. After washing with 120 column volumes of affinity wash buffer, fusion proteins and their interacting partners were eluted twice with 25 μL of either 10 mm glutathione, 10 mm Tris (pH 8), or affinity wash buffer plus 10 mm maltose. All experiments were repeated at least once. Phosphorylation and Dephosphorylation Assays Phosphorylation assays were carried out using either the procedure described by Williams et al. (1997) or, when using microsomes, that of Cabrillac et al. (2001). KAPP phosphatase activity was detected as described by Williams et al. (1997) using radiolabeled, autophosphorylated GST::SRK29kin prepared using the procedure described by Giranton et al. (2000). Sequence Analysis and Secondary Structure Predictions Sequence data analysis and construction of multiple sequence alignments were carried out using Lasergene sequence analysis software (DNASTAR, London). Neighbor joining trees were constructed from multiple alignments using ClustalW (Thompson et al., 1994) and NJplot (Perrière and Gouy, 1996). Secondary structure was predicted using a panel of programs available at the Web site of the Pôle Bio-Informatique Lyonnais (http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sspred.html). Reverse Transcriptase (RT)-PCR and RNA Gel-Blot Analyses Total RNA was isolated from a range of different organs of B. oleracea line P57Si using the method described by Cock et al. (1997). RT-PCR and RNA gel blot experiments were carried out as described by Channelière et al. (2002). Distribution of Materials Upon request, all novel materials described in this publication will be made available in a timely manner for noncommercial research purposes, subject to the requisite permission from any third party owners of all or parts of the material. Obtaining any permissions will be the responsibility of the requestor. We thank Shahinez Madi, Claire Rollin, Anne-Marie Thierry, Hervé Leyral, and Claudia Bardoux for technical assistance; Masao Watanabe for the SRK29 cDNA clone; and Daphne Goring, Erin Morris, John Walker, Steve Clark, and Steve Clouse for various PRK domain expression constructs. We are grateful to Gwyneth Ingram for her comments on the manuscript. Article, publication date, and citation information can be found at www.plantphysiol.org/cgi/doi/10.1104/pp.103.023846. ↵1 Present address: Swann Building, Institute of Cell and Molecular Biology, King's Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK. ↵2 Present address: Unité Mixte de Recherche 7139, Centre National de la Recherche Scientifique-Goëmar-Université Paris 6, Station Biologique, Place Georges Teissier, BP 74, 29682 Roscoff Cedex, France Received March 19, 2003. Revised April 15, 2003. Accepted June 23, 2003. Published October 10, 2003. 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Proc Natl Acad Sci USA 94: 10467–10472 Xu Y, Seet LF, Hanson B, Hong W (2001) The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J 360: 513–530 Thank you for your interest in spreading the word on Plant Physiology. You are going to email the following Interaction of Calmodulin, a Sorting Nexin and Kinase-Associated Protein Phosphatase with the Brassica oleracea S Locus Receptor Kinase Message Subject (Your Name) has sent you a message from Plant Physiology Message Body (Your Name) thought you would like to see the Plant Physiology web site. Plant Physiology Oct 2003, 133 (2) 919-929; DOI: 10.1104/pp.103.023846 The Cell Wall of the Arabidopsis Pollen Tube—Spatial Distribution, Recycling, and Network Formation of Polysaccharides Systems Dynamic Modeling of a Guard Cell Cl− Channel Mutant Uncovers an Emergent Homeostatic Network Regulating Stomatal Transpiration Architecture-Based Multiscale Computational Modeling of Plant Cell Wall Mechanics to Examine the Hydrogen-Bonding Hypothesis of the Cell Wall Network Structure Model Show more CELL BIOLOGY AND SIGNAL TRANSDUCTION Plant Physiology Preview

They are the interface between producers and consumers, using their own infrastructure and flexibility to supply existing demand for conventional and renewable liquid fuels, as well as non-liquid alternatives as part of the energy transition. They cover more than a third of Europe's current demand. The organisation brings together national associations and suppliers across Europe. Independent fuel suppliers bring competition to Europe's energy market and are able to respond rapidly to changes affecting supply, contributing to security on a local, national and regional level. They have developed and maintain a comprehensive infrastructure for the sourcing, storage and distribution of transport and heating fuels, with a commitment to delivering a high quality service to all consumers, including those in remote areas. Since 1962 UPEI has been advocating for a level playing field and fair competition to ensure an affordable, sustainable and secure energy supply for Europe's consumers. Today, in the context of the transition to a low carbon economy, UPEI and its members are also addressing the challenges of adapting the product range and meeting consumer demand through market oriented solutions.

Discussion in 'Mac OS X Server, Xserve, and Networking' started by macridah, Feb 5, 2006. Will the xServer be transitioning to intel chips as well? Will it be 64 bit? any chance we will find woodcrest in the desktop (aka mac pro)? Woodcrest is a codename. If Intel follows their past behavior, its official name will be Xeon. However, I wouldn't be surprised if they change, since they dropped the Pentium name for CoreDuo. ok, Im an Intel Noob. Whats the difference between Itanium and Xeon. Arent they both built for servers and workstations? They share the same target audience (more or less) - servers and workstations, as you say. I don't think you will ever see an Itanium in a Mac.

Building Civic Education in Bosnia During the summer of 1996, American and European teachers participated in the Civitas program described in the previous article. Its aim is to train Bosnian teachers in the use of curricular materials and methods promoting education for democracy. Among the American teachers who visited Bosnia in July to train their Bosnian colleagues were Pat Feichter, Gail Huschle and Mary Bristol. Here, they share some of their memories with the readers of Social Education. Their visit was organized by the Center for Civic Education of Calabasas, California, with the support of the United States Information Agency. Would I Return? In a Heartbeat!Pat FeichterMaine South High SchoolPark Ridge, Illinois When the Center for Civic Education asked me to volunteer to teach in Bosnia this summer, I jumped at the opportunity. Many people thought I was crazy, but I knew it would be a unique experience and one in which I could make a positive contribution in promoting democratic values.Entering Bosnia, it does not take long to experience destruction. Our seven hour bus trip to Sarajevo passed through dozens of war ravaged villages and towns. Some were selectively damaged, with only certain areas felled by artillery shells, while others were totally leveled. The once beautiful city of Mostar was one of the worst damaged. Everywhere in this Muslim-Croatian divided city there was evidence of war.Sarajevo, once the proud host of the 1984 Winter Olympic Games, is a city of burnt-out hulks. Over 1,300,000 artillery shells have struck Sarajevo. The effects were extensive and devastating. The Holiday Inn, where we stayed while in Sarajevo, is still marked by the effects of war. There are elevators and guest rooms with bullet holes and a stairway being repaired from a direct artillery hit.I was assigned to teach in the Canton of Travnik, 60 miles north of Sarajevo. I worked with one other American teacher and two Europeans, one from Germany and the other from Switzerland. This was the first time any of us had worked together. Flexibility and a willingness to compromise was a basic need. We were able to work together well.Our class had thirty participants. These were teachers of Muslim, Croatian, and Serbian background. We worked entirely through interpreters. Our facility was a Jesuit-founded secondary school 114 years old.Apprehension is the best way to describe our feelings going into this two-week course. Would the class understand us? Would they like us? Would they be willing to participate in simulations and group projects? The answer to this was a resounding yes!The Bosnian teachers, our students, were a joy to work with. They had a great sense of humor and an incredible interest in learning about democracy. Our mock trial and simulated election were two of the most popular activities. We became so close to members of our class that we were frequently invited to their apartments.People often ask me if I was frightened being in Bosnia. The answer is no. As long as you used common sense, there was nothing to fear. I walked the streets of both Travnik and Sarajevo in the evenings without a worry. However, you could not plan picnics in the countryside. An estimated 8 to 11 million landmines are a danger. You must stay on paved roads and sidewalks.One of the saddest effects of the war is the huge number of refugees living in squalor. They have very little food to eat. One man showed me a small piece of goat cheese, which was his only allotment of food for the day. These displaced people have in many cases been living in refugee centers for more than two years, and often don't know where their loved ones are or even if they are alive. The most we could do for them was to offer clothes, some food, and a small amount of money.Ethnic tensions do exist in Bosnia and are usually just below the surface. One evening on the streets of Travnik, I was approached by an irate group of Croatians. They were very upset because the person who selected the Bosnian teachers to attend our program was a Muslim. They were concerned about bias in the selection process. From time to time, we would hear stories about churches and mosques being bombed. Ethnic tensions are a fact of life in Bosnia.Would I return? In a heartbeat! Working with the Bosnian teachers was one of the most rewarding experiences of my life. In a small way I feel I may have helped further democracy and peace in this troubled land. n Beauty in the Midst of Devastation Gail HuschleSt. Croix Catholic SchoolStillwater, Minnesota When I remember my three weeks in Bosnia-Herzegovina, it is not the amazing physical beauty of the country nor the irony of that beauty contrasted with the terrible devastation of the towns which haunt me. Rather, it is the bond I formed with two remarkable women, Hajra Alibegovic and Azemina Masinovic. As we sat for one last cup of Turkish coffee in the Sarajevo Bashtasherie (Head Market), they asked me one last question: "After what you have seen here, do you feel we are foolish to want to forgive and forget?" Did I answer them "correctly?" I don't know.First, I should tell you about these two women. Hajra was my alter-ego, my translator. By the time two weeks had passed, she could anticipate what I would say next, often using the same inflection and hand gestures. She and her husband stayed in Travnik even though they might have fled. They were a secular family. They saw themselves as Bosnians first, not as members of an ethnic or religious group. They did send their two daughters abroad to study. Their younger daughter, Samra, served as our German translator; she hadn't been home for four years. I tried to imagine what it must have been like to miss the formative teen years of your child. Unimaginable. Hajra and her husband remained because, as the only English teacher, Hajra could not leave her students-all of whom maintained that she was the best teacher they ever had. As a psychiatrist, Hajra's husband could not leave his patients, many of whom bear the burdens of life in the military. This couple had links to Croatia, including a comfortable family home in Dubrovnik, yet they chose to stay in Travnik because they identify themselves as Bosnian. After their beautiful home on Vlashish Mountain was destroyed by the Serb forces, they found a small flat in town in which to withstand the four years of merciless shelling. Some of the blasts landed just a few feet from their building. Hajra somehow makes a positive out of this negative. She says she is liberated from the material things of life and now values friends and family more than ever. Perhaps that's why she gave me a lovely piece of lace handiwork from her own collection, and slipped a silver bracelet onto my wrist as we parted, saying, "There, now you must return because you are my sister!"Azemina is Hajra's best friend. She is Muslim. Correction! She is a Bosnian who lives as a Muslim in faith. Her husband's family has lived in Travnik for over 100 years. Her daughter was married in Germany during the war; she could "attend" through photos alone. I was invited to share a meal with Azemina and Hajra at Azemina's home. There we shared "pita," strawberry juice, and Turkish coffee. Azemina is an expert in the tedious art of making filo dough which encases the spicy meat of "pita." The men stopped by to invite us to walk around town in the nightly social promenade, but Azemina and I conspired to keep our evening only for the ladies. She told them my left leg hurt so that we could continue the talk of children, husbands, and weddings. She gave me Muslim prayer beads as I left to remind me of her whenever I prayed a rosary, since I am Roman Catholic.Throughout the two weeks, these women made me understand Bosnian hospitality. Both took delight in their shared culture; both took pride in the traditions of the other. Neither has patience for split national designations: Bosnian-Croats or Bosnian-Serbs or Bosnian-Muslims. Both want Bosnia for Bosnians.So, what was my answer to their last question? Are they foolish to forgive and forget the harms done in the last four years? No, I said, to take sides is to negate the nobility that your friendship signifies. To take sides is to make the idea of Bosnia-Herzegovina obsolete. n Making Connections Between Cultures Mary BristolAnchorage School District, Alaska "We now have clean air and empty pockets." This was how the residents of Zenica described the effects of the steel plant not operating there. High unemployment and buildings in need of maintenance were signs of war time difficulty. The vegetable gardens on the lawns of our hotel attested to the struggle for survival. Although predominantly Muslim, many residents spoke of the desire for an ethnically diverse and united Bosnia-Herzegovina as they offered us warm hospitality.Participants in our seminars were well prepared and actively involved. While their community has many pressing needs, it was evident they have a strong commitment to civic education. Class discussions were intense and questions were pertinent. They embraced new content and methods such as mock trials and town meetings. Participants vacillated between optimistic planning and confronting difficult realities.Our study of constitutionalism, authority, justice, and the role of the citizen in a democracy elicited powerful responses. Discussion of civic responsibility led to the sharing of experiences. One teacher told of observing a colleague stealing petroleum vital to the war. She struggled to determine what her responsibility was in those circumstances. Another recounted rescuing his mother from a war zone. He described his search, their hunger, and them walking many kilometers and crossing a mountain. Another explained that few had survived the sniper fire while ascending that particular mountain. It put my experiences in perspective.To provide practice in policy-making, we used Project Citizen, the program designed by the Center for Civic Education to help middle school students learn to work together with their communities on issues of public policy. As teachers identified community problems, it was clear that some-such as environmental issues, welfare, and educational concerns-are universal. Language differences meant that observing body language and obtaining translations of daily written summaries became important tools. As groups began working, I realized how much I normally use conversations to guide questions and evaluate progress. Awareness of different patterns of inter-cultural communication, especially of distinct speech and politeness systems, was essential to productive teaching. I used listening tools intensely. Our Bosnian colleagues spoke in a unique pattern. First they would tell us what they would be saying, next they would say it, and finally they would summarize what was said. Once I understood this pattern, it was easier to listen for the pertinent information. I tried to modify my presentation but found it difficult to change.We tried diligently to show respect for each other. That meant slowing down as we worked to build understanding. I tried not to ask questions too soon. While Americans are informal and direct, our hosts asked questions only after much conversation about a topic. Each tried to observe the other for clues to politeness. When our host said, "We might consider going to the restaurant" and then pulled out another cigarette, we realized that the leaving ritual was long.Bosnia is complex, fragile and difficult to understand. Regardless, the connection with Bosnian teachers was strong. We want the same things for our students. We worry about their preparation and opportunities to contribute to society. That is the essence of teaching.

Queens Theatre in the Park chooses new exec director By Times Ledger March 31, 2011 | 7:04pm Executive Director Jeffrey Rosenstock, Queens Theatre in the Park has a new man at its helm. Ray Cullom, the institution's choice for its new leader, brings 20 years of experience in arts administration, programming and production to the job, where he will oversee the venue, leading its artistic direction, finances and education programs as it moves into its third decade serving the borough. Cullom started his tenure at the theater, located in a historic building in Flushing Meadows Corona Park, March 14 and he said he hopes to enhance and expand on the services the theater provides its audiences. "This theater has a great history and has done wonderful things, and I hope to build upon that and elaborate on it," he said Tuesday. "What I would really love to do is fully use this venue. With its location and the great diversity and number of people that live within a short distance of the theater, this is a theater that should be more active several days a week. I hope to build the audience to include more of Queens and its surrounding communities." Frances Resheske, president of the theater's board of directors, said in a statement that Cullom's experience will complement and enhance the theater's goals. "He has done a remarkable job by setting both artistic and management vision at several institutions," Resheske said. "Our patrons and donors stand to benefit from Ray's leadership." He said one of his key hopes is that he can lead the theater into a period where it draws new audiences who might not usually attend arts performances. Cullom said Queens Theatre in the Park had great appeal to him because of its magnificent resources and its unique approach to both producing performances in-house and presenting outside works. Those assets were two of the key reasons he was drawn to Queens from his previous post as managing director of the Long Wharf Theatre in New Haven, Conn. Before that, Cullom served as executive director of the Bethesda Theatre in Bethesda, Md. Rosenstock said he is proud of the work he did at QTIP. "During my tenure, I led the transformation of an abandoned World's Fair building into a premier performing arts center," he said in a statement. "I am proud of our diverse programming and to have laid the foundation for future artistic development." Rosenstock's final season of programming at the theater will wrap in the coming weeks, and the fall QTIP season will be the first led by Cullom, who said the calendar should be released by mid-May. The theater recently completed a $27 million renovation and expansion that included the addition of a cabaret performance space and other amenities. For more information or to see a schedule of performances, visit queenstheatre.org. Reach reporter Connor Adams Sheets by e-mail at [email protected] or by phone at 718-260-4538. [email protected] LIC teacher tells story of rescuing son to 113th Pct.

Fake Brands – Symbols of Affluence or Mere Folly? Indecisive shopping attitude and uninformed (read impulsive) shopping sprees can end up in replicas of brand products – fake in the absolute sense. And when that is a high end label or a well-known international brand, much is at stake. Both for the buyer and the brand! In one of my online shopping sprees, I came across a website offering Louis Vuitton's totes at a marginally low-'low' cost. The double emphasis on the word 'low' is unusual and so was the offer in question! The website claimed to be part of the LV factory outlet, offering bags, totes and backpacks at a discounted price of more than 70%. By the virtue of being a Trademarks specialist (and a Louis Vuitton fan), I went ahead and bookmarked the website (http://www.louisvuttionsoutlet.org/) and decided to check its credentials, only to realize that the domain was registered in the name of one Lin Hong Hui from China. China can, for several reasons, be termed as the counterfeit "workshop" of the world. Guangzhou in South China is the epicenter of the world's counterfeit trade, wholesaling fake leather goods and apparel across the globe. The US customs and Border Protection Agency conducted nearly 25,000 seizures of counterfeit goods in 2013 alone, of which nearly 70% of came from China. With the growing demand of luxury products and the simultaneous growth of the counterfeits, fighting fakery has indeed become a tough battle. In 2014, American border officials nabbed counterfeits worth $1.2 billion. Their European Union counterparts seized fake products worth €768m ($1 billion) in 2013. While these numbers may seem high, the reality is that these are just a fraction of the total counterfeits being peddled. Estimates for the total value of fake goods sold worldwide each year could go as high as $1.8 trillion. The problem has aggravated as the business of counterfeits finds space in the virtual world. America's trade representatives predicted in April 2015 that online sales of pirated goods might exceed those in physical markets, adding that "Enforcement authorities unfortunately, face difficulties in responding to this trend. Online counterfeiters can stay anonymous, reach across borders and constantly launch new websites to evade legal action". In 2013, C2C retailer Taobao Marketplace (founded by the Alibaba Group in 2003) signed an agreement in with Parisian luxury brand Louis Vuitton to establish a cooperation mechanism for IP protection. But the irony here is that till date, Taobao offers wide range of counterfeit Louis Vuitton bags and totes on its website. Consumers and business owners both play complex roles here. Where few are always on the lookout for genuine products at discounted prices, others prefer them at marginally low prices. Some knowingly hunt for fakes and some are willing to pay the real price for a genuine product! The most troubling situation is for the brand owners, who either remain unwary or rather uninformed about the brand counterfeiting prevalent in the e-domain. Spotting the difference is the key! China's elite may have become too savvy for Louis Vuitton, but the luxury brand still remains popular among those who wish to own "branded" goods, albeit purchase them at a fraction of the original's price. But what happens, when you save up your savings to own a 'genuine' 'LV' and you end up with one which was manufactured at some local store at the Guangzhou district in China? With the growth of e-commerce platforms, counterfeits are just a click away! Spotting the difference and making an informed choice is the key to being a proud owner of the famous label. Originals come with a price and value. Stay original, let the fakes fade away. Brands such as Louis Vuitton have a value because of the high quality products they deliver. This means that the cost you pay is worth its shelf life. Support originals. Shun the fake. Abhilasha's interest in brand protection landed her into a job as a legal expert in trademarks. From Trademarks Searches to Trademarks Portfolio Management, Trademarks Prosecution and Advisory and Protection and Enforcement of IP rights, she loves her brand-loving job. And when she's not blogging, you can smell appetizing bakes wafting out of her kitchen. This blog is very helpful as its very difficult to differentiate branded stuffs, specially in Delhi where we have lot of fake products.

If you care about gay rights, you might want to rethink your drink. Gay rights groups are boycotting Russian vodka after the country cracked down on gay activists and pride parades, the BBC reports. In addition, new legislation makes it illegal to teach "non-traditional values" (ie. gay-friendly values) to children. On June 29, a gay pride parade in St. Petersburg was attacked by thugs and several marchers were badly beaten. Police then rounded up the marchers (not the thugs) and arrested them. You can see photos from this and related events in this shocking photo essay from Buzzfeed. The boycott started in the U.S. a few days ago and has since spread to other countries. Gay bars have pulled Russian vodka from their shelves and an online petition is calling for Manchester to "untwin" from its sister city St. Petersburg. Protesters have dumped vodka on the street in front of the Russian consulate in New York City and taken to Twitter with hashtags such as #dumpstoli and #dumprussianvodka. Homosexuality was decriminalized in Russia almost two decades ago but there's been a severe backlash against the LGBT community in recent years. One major vodka brand, Stolichnaya, has come out with a public statement in support of gay rights and says it shouldn't be targeted by the boycott. They say that while they use Russian ingredients, they are in fact a Latvian company. There's an ongoing discussion in the LGBT about expanding the boycott to include other Russian products and also the 2014 Winter Olympics in Sochi, Russia. Places of worship have long been points of interest for travelers. Solemn and usually quite ornate, these buildings provide a window onto a community's history and values and often give visitors a much-needed pause while pounding the sightseeing pavement. Cathedrals are typical for this kind of touring. But have you ever thought to pay a visit to a synagogue? My fascination with exploring synagogues began on a trip to Willemstad, Curaçao, home of Mikvé Israel-Emanuel, the oldest active Jewish congregation in the Americas built in 1651. Several years later, I had the opportunity to visit the Paradesi Synagogue in Cochin, Kerala, India. Constructed in 1568, it is the oldest "active" synagogue in India – "active" because there are fewer than 20 Jews left in Cochin, most having emigrated to Israel. Coincidentally, I learned about the Jews of Cochin from an exhibit at the 6th and I Synagogue, a historic synagogue in Washington, DC, that is now used primarily as a community center and arts space. The Jewish diaspora is thriving in many parts of the world. Yet in places like Cochin and Mumbai, the local Jewish community is dwindling, giving impetus to visiting some synagogues before they are shuttered or left to become museums. The following are some of the synagogues I have seen or wish to explore on my travels. From an island microslum in Colombia to a haute enclave in central Paris, the ten most crowded islands in the world bear scant similarities in class or culture. In fact, every entry in the top ten comes from a different country. But being islands, each shares the common thread of scarcity – whether it be land, resources, or housing. In general, these islands are prophetical microcosms for an overcrowded earth – finite spaces where self sufficiency governs and demand pierces supply. With the world's population racing higher and higher, and the "megacities club" accepting new members yearly, some day the earth could bear the traits of one of these densely packed islands. Story: This island located in St. Pete is a collection of 18th and 19th century buildings with some Soviet built apartment blocks lining the Gulf of Finland on the western shore. The communist housing ethos of the twentieth century called for rows and rows of tight apartments, and this historic island in Russia's second city was not immune to the sprawl. This created the compact quarters of Vasilyevsky island. Famous for its old school stock exchange and giant Rostral columns, the island is popular with tourists. Story: This small island in central Stockholm once served as a hub of industry for Stockholm's industrial operations. The easy boat access allowed for ease of shipping by boat, and the island factories manufactured an array of goods, from massive lamps for lighthouses to vacuum cleaners. Eventually, as the industrial applications became outmoded, the island became home to several apartment towers. Today, the island is crammed full of smiling Swedes living in apartments with (presumably) tasteful modern furniture. Story: Perhaps the most stylish island in the world, Île Saint-Louis is a marvel of 17th century urban architecture and planning. Narrow roads and some of the priciest real estate in the world have allowed the island to remain relatively calm, despite its location in central Paris. While Île Saint-Louis is off of the tourist radar for most, this island in the Seine River embodies the classic Parisian spirit, worthy of an afternoon stroll with a perfect sorbet from Berthillon. The island is named for France's canonized King, Louis IX. Story: In 1626, the Lenape Indians sold Manhattan island to the Dutch for a bag of axes, hoes, iron kettles, duffel cloths and other 17th century garb worth about $24 (roughly $1000 in modern value). It is safe to day the island has grown ambitiously from this humble transaction. The center of the financial universe is now home to many – truly a place where the world lives. The island once known as New Amsterdam, and briefly, New Orange, shadows America's story, both tragic and triumphant. Story: Salsette, an island off the western coast of India, is home to Mumbai and its sprawling suburbs. As a poster boy for "New India," Mumbai is as dichotomous as it gets, at once the wealthiest city in south Asia and also home to one of the world's largest slums – the notorious Dharavi. Dharavi is an island within an island, a super-slum with roughly one million people spread out over an area less than a square mile. At the other end of the spectrum, Salsette Island is also home to extreme wealth. The house known as Antilla is a 400,000 square foot giant that towers with some of Mumbai's tallest buildings. Truly a contrast from the squalor in Dharavi, the private residence houses six people, can accommodate 168 cars, has 9 elevators, and an ice room with snow flurries. Story: The Maldives is one of Asia's top tourist destinations, with 26 atolls and 1,192 islands offering beach perfection. At its center is the capital city – Male. Male is a humbly sized island of just a couple square miles. It is stuffed full of people, hotels, mosques, and office towers that efficiently utilize the scare land resources. While landfills have reclaimed some land from the sea, most progress is made vertically rather than horizontally. The modern downtown island in the middle of the Indian Ocean is a stark aberration from the deserted islands that dot most of the Maldives. Story: Hong Kong is the land of a thousand towers, clustered most densely on the island of Ap Lei Chau just southwest of Hong Kong Island. Ap Lei Chau served as the settlement for Hong Kong Village, theorized to be the etymological source for the famous larger territory of Hong Kong. Strangely, Ap Lei Chau translates to Duck Tongue Island, said to be named for the island's shape. It is filled with high rise residences and even a winery. Story: This bantomslum in the middle of Lake Victoria is a fishing village perched precariously on half a sphere of rock. The residents take in large hauls of the Nile Perch – a poster boy for River Monsters that can grow to a comedically large size. Migingo is famous for a decades-old dispute between Kenya and Uganda over the sovereignty of the small island. There is even a facebook page where individuals can "like" declaring the island Kenyan. (The page has twice as many followers as there are residents on Migingo.) Uganda agrees with this claim, most of the time, though the tiny rock island is not the issue – the fishing rights are. Story: The most densely populated island in the world is a microslum off the coast of Colombia. This tropical island is located in the emerald waters of the idyllic Caribbean, though is packed so tight that most activities are done off island. Schooling, football, graveyards, and work all take place away from Santa Cruz del Islote. The island park is the size of a small tennis court, and fresh water must be shipped in by Colombian Navy ships. Santa Cruz del Islote also does not have electricity. What the island favela does have is people, lots of them. To visit the world's most packed island, hop on a ferry from Tolu, Colombia. The nearby hotel of Punta Faro can arrange tours of the island. This quick trip around the world by filmmaker and photographer Alex Profit is a stunning display of photo-tourism. The video embarks on a journey through Paris, Barcelona, Berlin, St. Petersburg, Shanghai, Tokyo, New York and London. It will cure your nagging fits of wanderlust for the duration of its five minute run-time. Beyond that though, you may experience an uncontrollable urge to visit Barcelona or one of the other many locales documented. The video was made by compiling 2000 photographs from eight separate locations. It took Alex twenty-four days to travel to all of the locations and get the shots. That is covering a lot of ground, fast. If you could choose to travel to any of these locations, which one would you choose?

Covered in: Influence of Non-Saccharomyces on Wine Chemistry: A Focus on Aroma-Related Compounds Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications Quantum mechanics, Neuroscience, and Fuzzy logic allied together for promoting Chemical Artificial Intelligence Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives Journal Description Molecules is the leading international, peer-reviewed, open access journal of chemistry. Molecules is published semimonthly online by MDPI. The International Society of Nucleosides, Nucleotides & Nucleic Acids (IS3NA), the Spanish Society of Medicinal Chemistry (SEQT) and the International Society of Heterocyclic Chemistry (ISHC) are affiliated with Molecules and their members receive a discount on the article processing charges. Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions. High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, MEDLINE, PMC, Reaxys, Embase, CaPlus / SciFinder, and many other databases. Journal Rank: JCR - Q2 (Chemistry, Multidisciplinary) / CiteScore - Q2 (Chemistry, miscellaneous) Rapid Publication: manuscripts are peer-reviewed and a first decision provided to authors approximately 14.6 days after submission; acceptance to publication is undertaken in 2.9 days (median values for papers published in this journal in the second half of 2021). Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done. Testimonials: See what our authors say about Molecules. Sections: published in Twenty-six topical sections. Companion journals for Molecules include: Foundations and Photochem. Impact Factor: 4.412 (2020) ; 5-Year Impact Factor: 4.588 (2020) subject Imprint Information get_app Journal Flyer Open Access ISSN: 1420-3049 View online as: Abstract Page Chemical Composition and Metabolomic Analysis of Amaranthus cruentus Grains Harvested at Different Stages Tlou Grace Manyelo Nthabiseng Amenda Sebola Zahra Mohammed Hassan Jones Wilfred Ng'ambi William James Weeks Monnye Mabelebele Molecules 2022, 27(3), 623; https://doi.org/10.3390/molecules27030623 (registering DOI) - 19 Jan 2022 This study aimed at investigating the impact of early versus normal grain harvesting on the chemical composition and secondary metabolites of Amaranthus cruentus species grown in South Africa. Mature harvested grain had higher (p < 0.05) DM, CF, NDF and ADF content [...] Read more. This study aimed at investigating the impact of early versus normal grain harvesting on the chemical composition and secondary metabolites of Amaranthus cruentus species grown in South Africa. Mature harvested grain had higher (p < 0.05) DM, CF, NDF and ADF content compared to prematurely harvested grain. There were no significant (p > 0.05) differences between CP, ADL and GE of premature and mature harvested grains. Mature harvesting resulted in higher grain Ca, P, Mg and K content. Essential amino acids spectrum and content remained similar regardless of maturity at harvest. The grains displayed an ample amount of unsaturated fatty acids; the highest percentage was linoleic acid: 38.75% and 39.74% in premature and mature grains, respectively. β-Tocotrienol was detected at 5.92 and 9.67 mg/kg in premature and mature grains, respectively. The lowest was δ-tocotrienol which was 0.01 and 0.54 mg/kg in premature and mature grains, respectively. Mature harvested grain had a higher secondary metabolite content compared to premature harvested grains. The results suggest that mature harvested Amaranthus cruentus grain contain more minerals and phytochemicals that have health benefits for human and livestock immunity and gut function, which ultimately improves performance. This study concludes that A. cruentus grown in South Africa is a potential alternative cereal to major conventional cereals. Full article (This article belongs to the Special Issue Bioactive Phenolic and Polyphenolic Compounds-2nd Edition) Detection and Risk Assessments of Multi-Pesticides in Traditional Chinese Medicine Chuanxiong Rhizoma by LC/MS-MS and GC/MS-MS Delin Zhang Yan Gou Xingyu Yu Mei Wang Wen Yu Juan Zhou Wei Liu Min Li With the internationalization of traditional Chinese medicines (TCMs) and the increasing use of herbal medicines around the world, there are concerns over their safety. In recent years, there have been some sporadic reports of pesticide residues in Chuanxiong Rhizoma (CX), although the lack [...] Read more. With the internationalization of traditional Chinese medicines (TCMs) and the increasing use of herbal medicines around the world, there are concerns over their safety. In recent years, there have been some sporadic reports of pesticide residues in Chuanxiong Rhizoma (CX), although the lack of systematic and comprehensive analyses of pesticide residues and evaluations of toxicological risks in human health has increased the uncertainty of the potential effects of pesticides exposure in humans. This study aimed to clarify the status of pesticide residues and to determine the health risks of pesticide residues in CX. The findings of this study revealed that 99 batches of CX samples contained pesticide residues ranging from 0.05 to 3013.17 μg/kg. Here, 6–22 kinds of pesticides were detected in each sample. Prometryn, carbendazim, dimethomorph, chlorpyrifos, chlorantraniliprole, pyraclostrobin, and paclobutrazol were the most frequently detected pesticides, with detection rates of 68.69–100%. Insecticides and fungicides accounted for 43.23% and 37.84% of the total pesticides detected, respectively. Here, 86.87% of the pesticide content levels were lower than 50 μg/kg, and a small number of samples contained carbofuran, dimethoate, and isofenphos-methyl exceeding the maximum residue levels (MRLs). A risk assessment based on the hazard quotient/hazard index (HQ/HI) approach revealed that the short-term, long-term, and cumulative risks of pesticide residues in CX are well below the levels that may pose a health risk. Worryingly, six banned pesticides (carbofuran, phorate sulfone, phorate-sulfoxide, isofenphos-methyl, terbufos-sulfone, and terbufoxon sulfoxide) were detected. This study has improved our understanding of the potential exposure risk of pesticide multi-residues in CX. The results of the study will have a positive impact on improving the quality and safety of CX and the development of MRLs for pesticide residues. Full article LC-ESI-MS/MS Identification of Biologically Active Phenolics in Different Extracts of Alchemilla acutiloba Opiz Katarzyna Dos Santos Szewczyk Wioleta Pietrzak Katarzyna Klimek Anna Grzywa-Celińska Rafał Celiński Marek Gogacz Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, [...] Read more. Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts and roots of Alchemilla acutiloba led to the identification of phenolic acids and flavonoids. To the best of our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, narcissoside, naringenin 7-glucoside, 3-O-methylquercetin, naringenin, eriodictyol, rhamnetin, and isorhamnetin were described for the first time in Alchemilla genus. In addition, the antioxidant, anti-inflammatory and cytotoxic activity of all extracts were evaluated. The results clearly showed that among analyzed extracts, the butanol extract of the aerial parts exhibited the highest biological activity comparable with the positive controls used. Full article (This article belongs to the Special Issue Chromatographic Science of Natural Products II) Supplementary File 1 (ZIP, 177 KiB) DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6′-Diamino-1,1′,3,3′-Tetramethyl-5,5′-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione] Nesreen T. El-Shamy Ahmed M. Alkaoud Rageh K. Hussein Moez A. Ibrahim Abdulrahman G. Alhamzani Mortaga M. Abou-Krisha Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are investigated. Computational techniques such as the density functional theory, ADMET evaluation, and molecular [...] Read more. Heterocyclic compounds, including pyrimidine derivatives, exhibit a broad variety of biological and pharmacological activities. In this paper, a previously synthesized novel pyrimidine molecule is proposed, and its pharmaceutical properties are investigated. Computational techniques such as the density functional theory, ADMET evaluation, and molecular docking were applied to elucidate the chemical nature, drug likeness and antibacterial function of molecule. The viewpoint of quantum chemical computations revealed that the molecule was relatively stable and has a high electrophilic nature. The contour maps of HOMO-LUMO and molecular electrostatic potential were analyzed to illustrate the charge density distributions that could be associated with the biological activity. Natural bond orbital (NBO) analysis revealed details about the interaction between donor and acceptor within the bond. Drug likeness and ADMET analysis showed that the molecule possesses the agents of safety and the effective combination therapy as pharmaceutical drug. The antimicrobial activity was investigated using molecular docking. The investigated molecule demonstrated a high affinity for binding within the active sites of antibacterial and antimalarial proteins. The high affinity of the antibacterial protein was proved by its low binding energy (−7.97 kcal/mol) and a low inhibition constant value (1.43 µM). The formation of four conventional hydrogen bonds in ligand–protein interactions confirmed the high stability of the resulting complexes. When compared to known standard drugs, the studied molecule displayed a remarkable antimalarial activity, as indicated by higher binding affinity (B.E. −5.86 kcal/mol & Ki = 50.23 M). The pre-selected molecule could be presented as a promising drug candidate for the development of novel antimicrobial agents. Full article (This article belongs to the Special Issue Density Functional Theory in The Age of Chemical Intelligence) Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions Qian Xiao Qing-Xiao Tong Jian-Ji Zhong Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the [...] Read more. Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the most efficient and atom-economic approaches for the carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such as stoichiometric reagents or a specialized UV photo-apparatus were necessary suffering from various disadvantages. In particular, visible-light photoredox catalysis has also been demonstrated to be a greener and milder protocol for the thiol-ene/yne reactions in recent years. Additionally, unprecedented advancements have been achieved in this area during the past decade. In this review, we will summarize the recent advances in visible-light photoredox catalyzed thiol-ene/yne reactions from 2015 to 2021. Synthetic strategies, substrate scope, and proposed reaction pathways are mainly discussed. Full article (This article belongs to the Special Issue Photoredox Catalysis for Sustainable Chemical Synthesis/Medicinal Chemistry) Analytical Evaluation of Carbamate and Organophosphate Pesticides in Human and Environmental Matrices: A Review Nonkululeko Landy Mdeni Abiodun Olagoke Adeniji Anthony Ifeanyi Okoh Omobola Oluranti Okoh Pesticides are synthetic compounds that may become environmental contaminants through their use and application. The high productivity achieved in the agricultural industry can be credited to the use and application of pesticides by way of pest and insect control. As much as pesticides [...] Read more. Pesticides are synthetic compounds that may become environmental contaminants through their use and application. The high productivity achieved in the agricultural industry can be credited to the use and application of pesticides by way of pest and insect control. As much as pesticides have a positive impact on the agricultural industry, some disadvantages come with their application in the environment because they are intentionally toxic, and this is more towards non-target organisms. They are grouped into chlorophenols, organochlorines, synthetic pyrethroid, carbamates, and organophosphorus based on their structure. The symptoms of exposure to carbamate (CM) and organophosphates (OP) are similar, although poisoning from CM is of a shorter duration. The analytical evaluation of carbamate and organophosphate pesticides in human and environmental matrices are reviewed using suitable extraction and analytical methods. Full article (This article belongs to the Special Issue Frontiers in Analytical Methods for Water Analysis) Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production Sumeng Wang Yue Luo Wei Jiang Xiaomeng Li Qingsheng Qi Quanfeng Liang Several strategies, including inducer addition and biosensor use, have been developed for dynamical regulation. However, the toxicity, cost, and inflexibility of existing strategies have created a demand for superior technology. In this study, we designed an optogenetic dual-switch system and applied it to [...] Read more. Several strategies, including inducer addition and biosensor use, have been developed for dynamical regulation. However, the toxicity, cost, and inflexibility of existing strategies have created a demand for superior technology. In this study, we designed an optogenetic dual-switch system and applied it to increase polyhydroxybutyrate (PHB) production. First, an optimized chromatic acclimation sensor/regulator (RBS10–CcaS#10–CcaR) system (comprising an optimized ribosomal binding site (RBS), light sensory protein CcaS, and response regulator CcaR) was selected for a wide sensing range of approximately 10-fold between green-light activation and red-light repression. The RBS10–CcaS#10–CcaR system was combined with a blue light-activated YF1–FixJ–PhlF system (containing histidine kinase YF1, response regulator FixJ, and repressor PhlF) engineered with reduced crosstalk. Finally, the optogenetic dual-switch system was used to rewire the metabolic flux for PHB production by regulating the sequences and intervals of the citrate synthase gene (gltA) and PHB synthesis gene (phbCAB) expression. Consequently, the strain RBS34, which has high gltA expression and a time lag of 3 h, achieved the highest PHB content of 16.6 wt%, which was approximately 3-fold that of F34 (expressed at 0 h). The results indicate that the optogenetic dual-switch system was verified as a practical and convenient tool for increasing PHB production. Full article (This article belongs to the Special Issue Microbial Synthesis of Polymers and Polymer Precursors) Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies Alessia Catalano Domenico Iacopetta Jessica Ceramella Domenica Scumaci Federica Giuzio Carmela Saturnino Stefano Aquaro Camillo Rosano Maria Stefania Sinicropi Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, [...] Read more. Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID-19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance. Full article (This article belongs to the Section Medicinal Chemistry) Colorimetric and Electrochemical Methods for the Detection of SARS-CoV-2 Main Protease by Peptide-Triggered Assembly of Gold Nanoparticles Yunxiao Feng Gang Liu Ming La Lin Liu Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) has been regarded as one of the ideal targets for the development of antiviral drugs. The currently used methods for the probing of Mpro activity and the screening of its inhibitors require the [...] Read more. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) has been regarded as one of the ideal targets for the development of antiviral drugs. The currently used methods for the probing of Mpro activity and the screening of its inhibitors require the use of a double-labeled peptide substrate. In this work, we suggested that the label-free peptide substrate could induce the aggregation of AuNPs through the electrostatic interactions, and the cleavage of the peptide by the Mpro inhibited the aggregation of AuNPs. This fact allowed for the visual analysis of Mpro activity by observing the color change of the AuNPs suspension. Furthermore, the co-assembly of AuNPs and peptide was achieved on the peptide-covered electrode surface. Cleavage of the peptide substrate by the Mpro limited the formation of AuNPs/peptide assembles, thus allowing for the development of a simple and sensitive electrochemical method for Mpro detection in serum samples. The change of the electrochemical signal was easily monitored by electrochemical impedance spectroscopy (EIS). The detection limits of the colorimetric and electrochemical methods are 10 and 0.1 pM, respectively. This work should be valuable for the development of effective antiviral drugs and the design of novel optical and electrical biosensors. Full article (This article belongs to the Special Issue Functional Nanomaterials in Biomedicine) Supplementary File 1 (ZIP, 2580 KiB) Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions Anne Kokel Dora Kadish Béla Török The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates [...] Read more. The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates and biological probes, the efficient and selective deuteration methods are of great interest. The approach is based on selective H-D exchange reactions where the deuterium source is simple D2O. D2 gas is generated in situ from the reaction of aluminum and D2O, while the commercially available palladium catalyst assists the H-D exchange reaction. The high selectivity and efficiency, as well as the simplicity and safe nature of the procedure make this method an environmentally benign alternative to current alternatives. Full article (This article belongs to the Special Issue Organic Chemistry in the USA) Thyroid-Stimulating Hormone Favors Runx2-Mediated Matrix Mineralization in HOS and SaOS2 Cells: An In Vitro and In Silico Approach Ramajayam Govindan Mohamed El-Sherbiny Khalid Mohamed Morsy Ibraheem Srinivasan Narasimhan Mohamed EL-Dosoky Mohamed Salama Fazil Ahmad Selvaraj Jayaraman Vishnu Priya Veeraraghavan Srinivasan Vengadassalapathy Surapaneni Krishna Mohan Vidhya Rekha Umapathy Gayathri Rengasamy Shazia Fathima Jaffer Hussain Maheshkumar Poomarimuthu Senthilkumar Kalimuthu Osteoporosis is a skeletal disease that is both systemic and silent characterized by an unbalanced activity of bone remodeling leading to bone loss. Rising evidences demonstrate that thyroid stimulating hormone (TSH) has an important role in the regulation on the metabolism of bone. [...] Read more. Osteoporosis is a skeletal disease that is both systemic and silent characterized by an unbalanced activity of bone remodeling leading to bone loss. Rising evidences demonstrate that thyroid stimulating hormone (TSH) has an important role in the regulation on the metabolism of bone. However, TSH regulation on human osteoblast essential transcriptional factors has not been identified. Current study examined the role of TSH on human osteoblastic Runx2 expression and their functional genes by in vitro and in slico analysis. Human osteoblast like (HOS and SaoS-2) cells were cultured with DMEM and treated with hTSH at the concentration of 0.01 ng/mL and 10 ng/mL. After treatment, osteoblastic Runx2 and IGF-1R beta expression were studied using RT-PCR and western blot analysis. TSH treatment induced osteoblastic essential transcriptional factor, Runx2 in HOS and SaOS2 cells on 48 h duration and elevated the expression of IGF-IR β gene and Protein in SaoS-2 cells. TSH also promotes Runx2 responsive genes such as ALP, Collagen and osteocalcin in SaOS2 cells on day 2 to day 14 of 10 ng/mL of treatment and favors' matrix mineralization matrix in these cells. In addition, TSH facilitated human osteoblastic cells to mineralize their matrix confirmed by day 21 of alizarin red calcium staining. In silico study was performed to check CREB and ELK1 interaction with Runx2. Results of in silico analysis showed that TSH mediated signalling molecules such as CREB and ELK1 showed interaction with Runx2 which involve in osteobalstic gene expression and differentiation. Present findings confirm that TSH promotes Runx2 expression, osteoblastic responsive genes and bone matrix formation. Full article (This article belongs to the Special Issue Bioactive Molecules for Biodegradation and Antimicrobials) Effect of Extraction Procedures with Ultrasound and Cellulolytic Enzymes on the Structural and Functional Properties of Citrus grandis Osbeck Seed Mucilage Yu-Cheng Yeh Lih-Shiuh Lai The structural and functional properties of Citrus grandis Osbeck (CGO) seed mucilage by different extraction practices, including conventional citrate buffer, ultrasonic-assisted (UAE), enzymatic-assisted extraction (EAE) with cellulase or Celluclast󠅔® 1.5 L and various ultrasonic-assisted enzymatic extraction (UAEE) procedures were investigated. It was [...] Read more. The structural and functional properties of Citrus grandis Osbeck (CGO) seed mucilage by different extraction practices, including conventional citrate buffer, ultrasonic-assisted (UAE), enzymatic-assisted extraction (EAE) with cellulase or Celluclast󠅔® 1.5 L and various ultrasonic-assisted enzymatic extraction (UAEE) procedures were investigated. It was found that CGO seed from agricultural and processing byproducts is an excellent new source of high methoxyl pectin with quite high intrinsic viscosity (about 108.64 dL/g) and molecular weight (about 1.9 × 106) as compared with other pectin sources. UAEE with Celluclast󠅔® 1.5 L enhanced the extraction yield most pronouncedly (about 2.3 times). Moreover, the monosaccharide composition of CGO seed mucilage is least affected by EAE with Celluclast󠅔® 1.5 L. In contrast, EAE with cellulase dramatically reduces the galacturonic acid (GalA) content to less than 60 molar%, and increases the glucose (Glc) content pronouncedly (to about 40 molar%), which may be considered as an adverse effect in terms of pectin purity. Though extraction procedures involved with ultrasound and cellulolytic enzymes generally show a decrease in GalA contents, weight average molar mass and intrinsic viscosity, EAE with Celluclast󠅔® 1.5 L is least affected, followed by UAE and UAEE with Celluclast󠅔® 1.5 L. These features can be leveraged in favor of diversified applications. Full article (This article belongs to the Special Issue Molecular Characteristics and Functional Properties in Agri-Food) Prion Strains Differ in Susceptibility to Photodynamic Oxidation Marie Kostelanska Karel Holada Prion disorders, or transmissible spongiform encephalophaties (TSE), are fatal neurodegenerative diseases affecting mammals. Prion-infectious particles comprise of misfolded pathological prion proteins (PrPTSE). Different TSEs are associated with distinct PrPTSE folds called prion strains. The high resistance of prions to conventional [...] Read more. Prion disorders, or transmissible spongiform encephalophaties (TSE), are fatal neurodegenerative diseases affecting mammals. Prion-infectious particles comprise of misfolded pathological prion proteins (PrPTSE). Different TSEs are associated with distinct PrPTSE folds called prion strains. The high resistance of prions to conventional sterilization increases the risk of prion transmission in medical, veterinary and food industry practices. Recently, we have demonstrated the ability of disulfonated hydroxyaluminum phthalocyanine to photodynamically inactivate mouse RML prions by generated singlet oxygen. Herein, we studied the efficiency of three phthalocyanine derivatives in photodynamic treatment of seven mouse adapted prion strains originating from sheep, human, and cow species. We report the different susceptibilities of the strains to photodynamic oxidative elimination of PrPTSE epitopes: RML, A139, Fu-1 > mBSE, mvCJD > ME7, 22L. The efficiency of the phthalocyanine derivatives in the epitope elimination also differed (AlPcOH(SO3)2 > ZnPc(SO3)1–3 > SiPc(OH)2(SO3)1–3) and was not correlated to the yields of generated singlet oxygen. Our data suggest that the structural properties of both the phthalocyanine and the PrPTSE strain may affect the effectiveness of the photodynamic prion inactivation. Our finding provides a new option for the discrimination of prion strains and highlights the necessity of utilizing range of prion strains when validating the photodynamic prion decontamination procedures. Full article (This article belongs to the Special Issue Proteomics and Protein Biochemistry in Diseases) Polyphenolic Composition and Antioxidant Activity (ORAC, EPR and Cellular) of Different Extracts of Argylia radiata Vitroplants and Natural Roots Ady Giordano Pablo Morales-Tapia Mauricio Moncada-Basualto Josué Pozo-Martínez Claudio Olea-Azar Aleksandra Nesic Gustavo Cabrera-Barjas Plant biochemistry studies have increased in recent years due to their potential to improve human health. Argylia radiata is an extremophile plant with an interesting polyphenolic profile. However, its biomass is scarce and occasionally available. Argylia in vitro biomass was obtained from tissue [...] Read more. Plant biochemistry studies have increased in recent years due to their potential to improve human health. Argylia radiata is an extremophile plant with an interesting polyphenolic profile. However, its biomass is scarce and occasionally available. Argylia in vitro biomass was obtained from tissue culture and compared with in vivo roots regarding its polyphenolic and flavonoid content. Different solvents were used to prepare extracts from the in vitro tissue of callus and aerial plant organs and in vivo roots. UPLC-MS/MS was used to assess the chemical composition of each extract. ORAC-FL and scavenging of free radicals (DPPH and OH) methods were used to determine the antioxidant capacity of extracts. Furthermore, the biological activity of the extracts was established using the cellular antioxidant activity method. The vitroplants were a good source of polyphenols (25–68 mg GAE/100 g tissue FW), and methanol was the most efficient solvent. Eight polyphenolic compounds were identified, and their antioxidant properties were investigated by different chemical methods with EPR demonstrating its specific scavenging activity against free radicals. All extracts showed cellular dose-dependent antioxidant activity. The methanolic extract of vitroplants showed the highest cellular antioxidant activity (44.6% and 51%) at 1 and 10 µg/mL of extract, respectively. Vitroplants of A. radiata are proposed as a biotechnological product as a source of antioxidant compounds with multiple applications. Full article Open AccessSystematic Review Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation Catarina Gonçalves Daniela Fernandes Inês Silva Vanessa Mateus This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and [...] Read more. This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments. Full article (This article belongs to the Special Issue Medicinal Plants and Industrial Crops: Phytochemistry and Metabolic Diseases) Bone Dimensional Change Following Immediate Implant Placement in Posterior Teeth with CBCT: A 6-Month Prospective Clinical Study Witchayani Bungthong Parinya Amornsettachai Penporn Luangchana Boontharika Chuenjitkuntaworn Suphachai Suphangul This prospective clinical study aimed to evaluate the peri-implant hard tissue dimensional change at 6 months of immediate implant placement with bone graft materials in the posterior area using cone-beam computed tomography (CBCT). Twelve dental implants were placed concurrently following tooth extraction in [...] Read more. This prospective clinical study aimed to evaluate the peri-implant hard tissue dimensional change at 6 months of immediate implant placement with bone graft materials in the posterior area using cone-beam computed tomography (CBCT). Twelve dental implants were placed concurrently following tooth extraction in the posterior area and filled with xenograft particles. The CBCT images were taken immediately after surgical procedures and then at 6 months follow-up. To evaluate the hard tissue changes, the vertical and horizontal bone thickness were analyzed and measured using ImageJ software. Paired t-test or Wilcoxon match-pair signed-rank test was done to analyze the changes of hard tissue values at the same level between immediately and 6 months following immediate implant placement. Independent t-test or Mann–Whitney U test was used to analyze the dimensional change in the vertical and horizontal direction in buccal and lingual aspects. The level of significance was set at p value = 0.05. All implants were successfully osseointegrated. At 6 months follow-up, the vertical bone change at the buccal aspect was −0.69 mm and at the lingual aspect −0.39 mm. For horizontal bone thickness, the bone dimensional changes at 0, 1, 5, and 9 mm levels from the implant platform were −0.62 mm, −0.70 mm, −0.24 mm, and −0.22 mm, respectively. A significant bone reduction was observed in all measurement levels during the 6 months after implant placement (p value < 0.05). It was noted that even with bone grafting, a decrease in bone thickness was seen following the immediate implant placement. Therefore, this technique can be an alternative method to place the implant in the posterior area. Full article (This article belongs to the Special Issue Advancements of Materials for Prosthodontics and Dental Implantology) The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models Jianbo Wu Kenchi Miyasaka Wakana Yamada Shogo Takeda Norihito Shimizu Hiroshi Shimoda Ampelopsis grossedentata (AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatoprotective effects. Researchers in China recently reported the [...] Read more. Ampelopsis grossedentata (AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatoprotective effects. Researchers in China recently reported the anti-obesity effects of AG extract in diet-induced obese mice and rats. To verify these findings, we herein investigated the effects of AG extract and its principal compound, ampelopsin, in high-fat diet (HFD)- and alcohol diet-fed mice, olive oil-loaded mice, and differentiated 3T3-L1 cells. The results obtained showed that AG extract and ampelopsin significantly suppressed increases in the weights of body, livers and abdominal fat and also up-regulated the expression of carnitine palmitoyltransferase 1A in HFD-fed mice. In olive oil-loaded mice, AG extract and ampelopsin significantly attenuated increases in serum triglyceride (TG) levels. In differentiated 3T3-L1 cells, AG extract and ampelopsin promoted TG decomposition, which appeared to be attributed to the expression of hormone-sensitive lipase. In alcohol diet-fed mice, AG extract and ampelopsin reduced serum levels of ethanol, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) and liver TG. An examination of metabolic enzyme expression patterns revealed that AG extract and ampelopsin mainly enhanced the expression of aldehyde dehydrogenase and suppressed that of cytochrome P450, family 2, subfamily e1. In conclusion, AG extract and ampelopsin suppressed diet-induced intestinal fat accumulation and reduced the risk of fatty liver associated with HFD and alcohol consumption. Full article (This article belongs to the Topic Applied Sciences in Functional Foods) Transformation of Thia[7]helicene to Aza[7]helicenes and [7]Helicene-like Compounds via Aromatic Metamorphosis Keisuke Uematsu Chikara Hayasaka Ko Takase Keiichi Noguchi Koji Nakano [n]Helicenes with helically twisted structures have attracted increasing interest owing to their unique properties. Therefore, it has been an important issue to develop facile synthetic methodologies which allow access to a variety of [n]helicenes. Here we report the synthesis [...] Read more. [n]Helicenes with helically twisted structures have attracted increasing interest owing to their unique properties. Therefore, it has been an important issue to develop facile synthetic methodologies which allow access to a variety of [n]helicenes. Here we report the synthesis of [7]helicenes and [7]helicene-like compounds from the thia[7]helicene as a common starting material. Desulfurative dilithiation of the thia[7]helicene and the subsequent reaction with silicon and phosphorus electrophiles afforded the silole- and phosphole-fused [7]helicene-like compounds, respectively. The cyclopentadiene-fused [7]helicene-like compound and the pyrrole-fused aza[7]helicenes were also successfully synthesized via twofold SNAr reactions of the thia[7]helicene S,S-dioxide with the carbon and nitrogen nucleophiles, respectively. The thia[7]helicene S,S-dioxide showed a slightly red-shifted absorption spectrum than the parent thia[7]helicene, which was well demonstrated by the theoretical calculations. The substituents on the silicon atom of silole-fused [7]helicene-like compounds have little impact on the longest absorption maximum. Such little effect of the substituents on absorption properties was also observed for cyclopentadiene-fused [7]helicene-like compounds and aza[7]helicenes and was well demonstrated by the theoretical calculations. The thia[7]helicene S,S-dioxide and the silole-fused [7]helicene-like compound exhibited bright blue emission, and the cyclopentadiene-fused [7]helicene-like compound and the aza[7]helicenes showed strong violet emission. Each single enantiomer of the aza[7]helicenes showed circularly-polarized luminescence with the dissymmetry factors of 4.2⁓4.4 × 10−3. Full article (This article belongs to the Special Issue Polycyclic(hetero)aromatic Compounds) Cationic Emulsion Polymerization of Octamethylcyclotetrasiloxane (D4) in Mixtures with Alkoxysilanes Janusz Kozakiewicz Joanna Trzaskowska Michał Kędzierski Joanna Sołtysiak Elżbieta U. Stolarczyk Izabela Ofat-Kawalec Jarosław Przybylski The cationic emulsion polymerization of octamethylcyclotetrasiloxane (D4) in mixtures with methyltriethoxysilane (MTES) and vinyltriethoxysilane (VTES) was studied by FTIR ATR, GC, the development of a toluene insoluble fraction of the polymer and a gravimetric analysis. The polymerization of D4 alone was also conducted [...] Read more. The cationic emulsion polymerization of octamethylcyclotetrasiloxane (D4) in mixtures with methyltriethoxysilane (MTES) and vinyltriethoxysilane (VTES) was studied by FTIR ATR, GC, the development of a toluene insoluble fraction of the polymer and a gravimetric analysis. The polymerization of D4 alone was also conducted for comparison and, additionally, the development of molecular weight of polydimethylsiloxane (PDMS) obtained in that process was studied by GPC. Dodecylbenzenesulphonic acid (DBSA) was used as a surfactant and catalyst. The process was carried out in a "starved feed" mode by adding dropwise the monomer mixture to the aqueous solution of DBSA. FTIR ATR spectra were recorded by the sensor placed in the probe tip of a ReactIR 15TM apparatus. It was found that the silicone polymer formation proceeded faster when D4 was polymerized in the mixture with alkoxysilanes, especially in the beginning of the process, and that already at the beginning of the process, the partly crosslinked polymer was formed. The induction period of ca. 30 min was observed and the concentration of cyclic siloxanes (D4 and decamethylcyclopentasiloxane—D5) remained at a very low level in the course of the reaction and only traces were detected in the final product. The particle size development in the course of the reaction was also studied and it was found that the particle size distribution was bimodal and was broadening as the reaction proceeded, though this phenomenon was less distinct when D4 was polymerized in the mixtures with alkoxysilanes. The structure of the reaction product was confirmed by 29Si NMR. Full article (This article belongs to the Special Issue Various Aspects of Silicon Polymer Chemistry: A Themed Issue in Honor of Professor Julian Chojnowski on the Occasion of His 85th Birthday) A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis Hebah Muhsien Sabiah AL Ubeed Deep Jyoti Bhuyan Muhammad A. Alsherbiny Amrita Basu Quan V. Vuong Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of [...] Read more. Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of the current extraction methods implemented in the Cannabis industry and scientific literature to produce consistent, reliable, and potent medicinal Cannabis extracts is prudent. Furthermore, these processes must be subjected to higher levels of scientific stringency, as Cannabis has been increasingly used for various ailments, and the Cannabis industry is receiving acceptance in different countries. We comprehensively analysed the current literature and drew a critical summary of the extraction methods implemented thus far to recover bioactive compounds from medicinal Cannabis. Moreover, this review outlines the major bioactive compounds in Cannabis, discusses critical factors affecting extraction yields, and proposes future considerations for the effective extraction of bioactive compounds from Cannabis. Overall, research on medicinal marijuana is limited, with most reports on the industrial hemp variety of Cannabis or pure isolates. We also propose the development of sustainable Cannabis extraction methods through the implementation of mathematical prediction models in future studies. 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First US order for EC145 Mercedes-Benz Style 30-Oct-2012 Source: American Eurocopter American Eurocopter today announced Speedway Aviation in New Hampshire has placed the first U.S. based order for the new EC145 Mercedes-Benz Style helicopter, featuring an exclusive, special edition package like nothing seen before in the helicopter industry. The aircraft is the result of a collaborative effort between Eurocopter, the world's leading producer of corporate and VIP helicopters, and Mercedes Benz, the automotive group that sets global standards for luxury and style. This will be the third special edition EC145 Mercedes-Benz Style to be produced since its introduction in late 2010 and the first to be operated in the United States. JBI Helicopters of New Hampshire will be managing the newest EC145 Mercedes Benz-Style helicopter for Speedway Aviation once it is delivered to its New England based owners in 2013. The client's decision to purchase the EC145 was made after an exhaustive review of each of the twin-engine helicopters on the market. "The Eurocopter product was selected because of its safety record, reliability, and supportability," said Kurt West, vice president of JBI Helicopter Service. "The Mercedes-Benz Style package was the perfect complement to an already impressive product and the client sees the value in having the leaders in automotive interior design working with the helicopter experts." "It's the perfect marriage of the safest, most reliable, helicopter in its class and a stylish finish created by Mercedes-Benz," says American Eurocopter's Vice President of Commercial Sales and Marketing, Treg Manning. "We are confident that our clients here in the U.S. will be impressed when they see this special edition EC145 and expect there will be an increasing demand for the aircraft, particularly since the package will also be available on the next generation EC145T2. Once that aircraft enters full production, we are sure to see the relationship with Mercedes-Benz continue for years to come." Created by the Mercedes-Benz Advanced Design Division based in Como, Italy, the package is the most comprehensive available, featuring exquisite leather and wood appointments, an advanced in-flight entertainment system, ambient lighting, modular storage cabinets that can be easily reconfigured, and the choice of up to eight-place seating. The design team has also modified the external look of the EC145 to give it a distinguished appearance including a redesign of the front end, special shrouding for the skid gear, and a custom paint scheme. The twin-engine EC145 has proven its worth in many roles, making it the obvious platform of choice for this exclusive package. It offers not only a very large and comfortable cabin area but also two rear doors that make it extremely easy to load luggage, sporting equipment or the spoils from shopping trips. With skid gear, the aircraft has greater flexibility for landing, including unprepared surfaces such as an open field near the hunting lodge or a grassy knoll at the golf course. With the EC145's advanced auto-pilot system and avionics, the pilots can spend more time focusing on the environment outside of the aircraft thereby providing more safety for the passengers. The search to find the best product led Mr. West to a number of locations on behalf of his client, including Donauwörth, Germany, where the Eurocopter production line for the commercial version of the EC145 is located; Stuttgart, Germany, for a look behind the curtain at the Mercedes-Benz headquarters; Como, Italy, to meet with the design team; and finally Grand Prairie, Texas, to visit the training academy and customer support management at American Eurocopter's headquarters. "Being able to witness firsthand the vast infrastructure and people standing behind this product was very important," said West. "Our client demands only the best and we believe American Eurocopter will deliver just that." About American Eurocopter American Eurocopter is the U.S. affiliate of Eurocopter, the largest helicopter manufacturer in the world, and a subsidiary of EADS North America Holdings, the North American operations of EADS, the second largest aerospace and defense company in the world. American Eurocopter is a helicopter manufacturer and markets, sells and supports the broadest range of civil and parapublic helicopters offered by any manufacturer. The product line represents the most cost-effective, technologically-advanced helicopters, ranging from light single to heavy twin, serving all markets and missions. Company headquarters and main facility are in Grand Prairie, TX, with a large manufacturing and production facility in Columbus, MS. American Eurocopter, Civil, EC145, Eurocopter, JBI Helicopters, NBAA 2012, News, Speedway Aviation, US-New Hampshire SAFE delivers EC145 Maintenance Stands to Riverside County Sheriff Where now for helicopter support of offshore wind farms in Europe? DRF Bremen base updates from EC145 to H145 07-Mar-22 N29VA Airbus EC145 Abingdon, US-Virginia Metro displays two air medical aircraft at SHIFT AMTC 2021 Childrens of Alabama upgrades from Bell 407 to Airbus EC145 Metro Aviation launches new Garmin GTN 650/750 Xi STC with Geisinger Life Flight Hessen Police continues partnership with US Army Garrison in Germany 20-Apr-21 (serial TBC) Airbus UH-72A New Brockton, US-Alabama 04-Apr-21 N145SD Airbus EC145 Sioux Falls, US-South Dakota Two Japanese prefectures sign helicopter cooperation agreement Airbus improves EC145 anti-collision light SAFE provides maintenance stands to New Mexico State Police DRF Christoph Weser to upgrade Bremen air ambulance to EC145 Mountain Area Medical Airlift adds EC145e to fleet Air Methods chooses Airbus HCare to support its fleet of 31 EC145 helicopters 06-Aug-20 PK-JBX Airbus H145 Batulicin, Indonesia DRF "Christoph 42" in Schleswig-Holstein upgrades from EC145 to H145 First Ukraine Police Airbus H145 commences flight test phase Gama Aviation starts Scottish EMS operations after taking contract back from Babcock

Pop/Bollywood Music I'd like to kiss Adele: Rick Ross I'd like to kiss Adele: Rick Ross Hip-hop superstar Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her. By: PTI Los Angeles | January 20, 2016 12:31 IST Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her. Hip-hop superstar Rick Ross admits he is in love with Adele's new album 25 and he'd like to kiss her. "I love Adele. When I see her, I may kiss Adele. "She speaks for so many people. When I hear her voice, I stop and make that face and say, 'What is this man?' I just gaze off into the sky for a second and think creatively," he said. And Ross, 39, is keen to hit the studio with the "Hello" singer, adding, "I've got a beat ready for her if I ever run across her." Adele recently proved her love of hip-hop after joining British comedian and TV host James Corden for a 'carpool karaoke' sketch on his US talk show, during which she rapped along to Nicki Minaj's verse on Kanye West's 2010 hit "Monster", which also featured Ross and Jay Z. Leonardo DiCaprio deserves an Oscar win: Kate Winslet EntertainmentAamir Khan sings Raja Hindustani song, dances with Kartik Aaryan at Bhopal wedding EntertainmentPathaan crosses Rs 500 crore mark globally Metro… In Dino team celebrates Saraswati Puja: Sara Ali Khan gives it a miss, but Kartik Aaryan attends Priyanka Chopra parties with Sofia Vergara, Jessica Alba and Heidi Klum 20 best photos from Athiya Shetty-KL Rahul's wedding

Child Tax Benefit Payment Dates 2023 The unfortunate reality of having children is that they're expensive. Some people aren't able to easily cover all of the cost that come from housing and caring for children. These astronomical expenses cause financial strain and undue stress to thousands of people across the country, especially with the ever-rising and crippling effects of inflation driving prices of everyday items even higher. Because of this, there have been many provincial and federal government programs established to provide parents with a bit of financial assistance. One of the most popular such programs is the Canada Child Benefit, or CCB. In this article we'll tell you everything you need to know about Child Tax Benefit payment dates. What is the Canada Child Benefit (CCB)? Before we delve into the complicated business of explaining child tax benefit payment dates, we first need to discuss what the Canada Child Benefit (CCB) is. The Canada Child Bernefit is a benefit program exempt from taxes that's made available to parents who meet the eligibility requirements and have children under 18 years of age. The benefit program's goal is to ease some of the financial burden of parents facing poverty by providing them with financial aid offered by the government. Here are some of the eligibility requirements for the Canada Childe Benefit (CCB): You must be a primary caregiver The child must be under 18 years of age The child must live with you The child must be a Canadian resident Either you or your spouse has to be a Canadian citizen, protected person, permanent resident, a temporary resident living in Canada for at least 18 months or possesses a valid permit, or an Indigenous person (which is defined under the Indian Act). How Much Money Can You Get Through the Canada Child Benefit (CCB)? Another important thing we should discuss before jumping into the Child Tax Benefit payment dates is how much money you can get through the Canada Child Benefit. In 2021, the tax year ran from July 2021- June 2022. The maximum amount of money you could receive for a child under 6 years old was $6,833, and the maximum amount you could receive for a child between 6 and 17 years of age was $5,765. However, if you have joint custody of your child then you'll receive half of the amount you'd have received if you had full custody of the child. Maximum CBB Benefits Age Per Year Per Month Under 6 years old $6,833 $569.41 6-17 years old $5,765 $480.41 The Canadian government calculates the amount of your monthly payment using your tax returns from the previous year. There's a CCB calculator on the Canadian government's website that you can use to get an estimated monthly payment calculation. Some of the factors that affect the amount of your monthly payment are: How many children you have Your family's net combined total income If you child is eligible for child disability benefits Your residential status and if you qualify to receive provencial benefits Your marital status How Does Income Affect Your Canada Child Benefit (CCB) Amount? If you're new to CCB payments and looking up Child Tax Benefit payment dates, then you'll probably need to know how your income can affect your Canada Child Benefit amount. One of the major determining factors used to decide your Canada Child Benefit amount is your family's net combined income. For instance, if your family's net income is less than $32,028 then you qualify for the maximum benefit amount. That amount goes down if your income is higher than that, or if you have more children. Here's how to calculate Canada Child Benefit (CCB) payment amounts: Subtract the income threshold from your income to get your income over threshold amount. Multiply the income over threshold amount by the reduction percentage. To your reduction, add the fixed amount. Subtract your reduction amount from the maximum benefit amount. Canada Child Benefit (CCB) Payment Amounts According to Income Level and Number of Children Number of Children Net Income of Family Over $32,028- $69,395 Net Income of Family over $69,395 1 7% of income over the threshold $2,616 + 3.2% of income over the threshold 2 13.5% of income over the threshold $5,044 + 5.7% of income over the threshold 3 19% of income over the threshold $7,100 + 8% of income over the threshold 4 or more 23% of income over the threshold $8,594 + 9.5% of income over the threshold Extra Temporary Canada Child Benefit (CCB) Payments One thing that may be useful to know if you're looking up information about Child Tax Benefit payment dates is the Extra Temporary Canada Child Benefit (CCB) payments. These extra payments were issued because of the additional strain that COVID-19 put on parents. Studies indicate that 20,000 left the workforce while 68,000 men joined the workforce due to COVID-19. Of those over 20,000 women, at least 2/3 of them quit their jobs due to a lack of childcare. Because of this, the Canadian government stepped in and offered additional assistance for families. Eligible applicants can receive somewhere between $600 and $1,200 in addition to their Canada Child Benefit. You qualify for the maximum payment of $1,200 if your household income is less than $120,000 and you'll receive the payment in the form of quarterly installments of $300. You qualify for $600 if y9ur family's household income is more than $120,000, and you'll receive it in quarterly installments of $150. The extra CCB payments for a family that makes less than $31,711 amounted to $7,965 for children under six, and $6,908 for kids 6-17 years of age. If you've come across this Child Tax Benefit Payment Dates article after 2020, then this bit of information likely isn't pertinent to you, save for historical or informative purposes. Child Tax Benefit Payment Dates (CCB Dates) If you're looking for child tax benefit payment dates, then you've come to the right place, because we're going to discuss them and lay them all out in this section. The first thing you should know about child tax benefit payment dates is that their calendar year runs from June to July of the next year. If you sent in an application online, you can expect your first CCB payment within about 8 weeks, 11 if you applied by mail. The following is a list of child tax benefit dates: Child Tax Benefit Payment Dates 2021: As you can see, the majority of child tax benefit payment dates are between the 18th and 20th of the month, with the exception of December when payments are understandably issued a bit earlier before government agencies are closed for the holiday season. Additionally, if your yearly CCB payments are under $240 then instead of receiving monthly payments on child tax benefit payment dates, you'll receive one payment for the year in July. How to Apply for Canada Child Benefit If you've yet to apply for the Canada Child Benefit or CCB, it's a good idea to learn more about the application process while you're learning about child tax benefit payment dates. You have two different options when it comes to applying for the CCB. The first option available to you is to apply for the CCB when your child is born. You can accomplish this by registering at the medical centre where your child was born, at the same time you're registering their birth documents. Be sure that you sign the necessary section to provide consent to the Vital Statistics Agency to provide the Canada Revenue Agency (CRA) with the appropriate information. If you live in British Columbia, Ontario or Quebec, then you can do the registration online yourself. CRA (Canada Revenue Agency) Application If you didn't sign up for the CCB when your child was born (or didn't need to at the time), then you can sign up online using the CRA website. You'll need to make an account and then enter some information about your child, such as their date of birth, name and more. If you choose to apply by mail instead, then you'll need to fill out the RC66 form, then send it to a tax center near you. Here are some other documents you may be required to send in along with your application: Proof of Birth of the Child You'll need to provide proof of birth for any child who hasn't received CCB from birth, was born outside of Canada, or is a year or more of age. Letter from Female Parent If you're a male parent who is primarily in charge of caring for the child and providing for them, then you may need a letter from the female parent to confirm this situation. However, if the child is primarily cared for by the female parent then a letter isn't typically required. Miscellaneous Documents from the Past 11 Months So long as your child was living with you 11 months ago, you'll have to present documentation to prove this, as well as your citizenship, your child's citizenship and documents to prove that you're the child's primary caregiver and have been for the past 11 months. What are Child Tax Loans? How to Cancel E-transfer FAQs about the Child Tax Benefit Payment Dates What were the 2018 child tax benefit payment dates? This information isn't readily available online, unfortunately. We did extensively look. Considering the CBB has only existed since 2016, some of the past child tax benefit payment dates aren't listed online and have become difficult to find as a result. However, finding child tax benefit payment dates for the years 2020 and beyond are quite easy. This is likely due to a push for online listings during the height of the Covid-19 pandemic. What are the 2022 child tax benefit payment dates? The child tax benefit payment dates for 2022 are: January 20, 2022 February 18, 2022 March 18, 2022 April 20, 2022 May 20, 2022 June 20, 2022 July 20, 2022 August 19, 2022 September 20, 2022 October 20, 2022 November 18, 2022 December 13, 2022 The CRA website says that if you haven't received a payment on the child tax benefit payment dates to wait 5 days before notifying them. The 2023 child tax benefit payment dates are: January 20, 2023 February 20, 2023 March 20, 2023 April 20, 2023 May 19, 2023 June 20, 2023 July 20, 2023 August 18, 2023 September 20, 2023 October 20, 2023 November 20, 2023 December 13, 2023 What's the maximum CCB payment I can get? As of 2022, the maximum CCB benefit payment is $6,833 per year per child under 6 years of age, and $5,765 per year per child 6-17 years of age. Of course, these numbers are dependent on loads of factors, such as your household income, the number of children you have, your custody status and more. You can quickly find out how much you're likely to get by using the government's child and family benefits calculator, which you can find here. Can I receive other benefits for my child? Yes! There are several other provincial child benefit programs, and many of them work along with the CCB. This means you can potentially receive these benefits in addition to your CCB payments. Here are some of the provinces that provide child benefit programs in addition to the CCB: In addition, in 2020 Alberta created the Alberta Child and Family benefit program, which is a combination of their previous programs, the Alberta Family Employment tax credit and the Alberta Child Benefit. Quebec offers several child benefit programs: Family allowance payment Supplement for the purchase of school supplies Supplement for handicapped children requiring exceptional care If you've ever wondered, what is a routing number? You've come to the right place. In C... A payday loan is a short-term loan typically due on or around the borrower's next paych... Aging is the enemy of life, no matter how lovely living is. You wouldn't want your pare... Employment insurance, or EI, is a program, also known as the EI program, in Canada that... If you're either of retirement age or approaching it, then you're probably wondering ab... Home > Child Tax Benefit Payment Dates 2023

WI Ensnared in 2020 Voter-Purge Debate Another Legal Challenge Filed Over New Pork Processing Rules Christmas in July: National Tree Competition Comes to Michigan PHOTO: Michigan tree growers are hoping for host state luck this year, as the nation's top Christmas tree growers meet in Allegan to compete for the honor of providing this year's official White House Christmas tree. Photo courtesy of the Michigan Christmas Tree Association. ALLEGAN, Mich. - It may be July, but it's still the most wonderful time of the year for the nation's top Christmas tree growers, who are bringing their finest specimens to Michigan to vie for the honor of providing this year's official White House Christmas tree. Rick Dungey, executive director of the National Christmas Tree Association, says the selection is a rigorous contest, with five pages of specifications and three separate rounds of judging. "They want the tree to go exactly to the top of the ceiling and that measurement is 18-and-a-half foot," says Dungey, "so they can't pick a 17-foot tree or even an 18-foot tree." Because it is so early in the year, a White House representative will go to the winning tree farm later in the season to select the official tree that will be placed in the Blue Room. Michigan is the nation's third largest producer of Christmas trees, with more than 38,000 acres of Christmas tree farms. Dungey says a high profile tree like the one for the White House isn't just ceremonial. It also helps spread the word about the environmental benefits of real Christmas trees. He feels younger consumers are leading the charge on that front. "I think they know that agricultural products, particularly Christmas trees, can be sourced locally in most places around the country, and they always know it's better to use a natural product, a renewable resource that's easily recycled, over a PVC, non-biodegradable, plastic and metal thing that's going to end up in a landfill," he says. Michigan growers have been selected to provide the official White House tree on several occasions, most recently in 1985. The judging will be done by a panel of growers, industry experts, and consumers at Peterson's Riverview Nursery in Allegan on Friday and Saturday. Mona Shand, Public News Service - MI

OUR TEAMOPERATING PRINCIPLESOUR STORYADVISORY COUNCILCLIENT PARTNERSJOIN OUR TEAM the davinci difference IMPLEMENTATION APPROACHSTANDOUT FEATURESleo INTEGRATIONSleo FAQS studentsfacultystaffleadershiptech teams Absolutely obsessed with learning, teaching & growing. Chris has been an advocate for DaVinci Education since his days as a super user at the University of North Carolina School of Medicine, where he worked for seven years prior to joining our team. An avid fan of auto races, Chris can't help describing Leo as "Formula One," referring to what he considers to be the software system's world-class engineering and capabilities. At UNC, Chris first managed the medical school's evaluation and management system as Software Technician and later became Business System Analyst/IT Project Manager. Now Chris enjoys being on the other side, advising clients on best practices with Leo and their program management in general. He also contributes to ongoing product development discussions, leveraging his valuable insights as a former medical school administrator. Chris says, "It's a very rewarding environment working at DaVinci Education. It's honest, it's matter-of-fact, and things move forward quickly. And if someone does their job really well, they're quick to get praise. I believe in the product and in the team, it's a great place to be." As a middle school student, Chris was once hired to build four hundred computers from scratch. He went on to earn a bachelor's degree in business management, with minors in accounting and economics, from North Carolina State University. In his down time, Chris continues to follow races every chance he gets, and recently took his mom to the Indy 500, knocking one off her bucket list as well. Originally from Rutherford County, Chris is happy to have made his home in Durham, NC. Other key players Implementation Trainer Myke Programmer/Analyst PhD, MEd Director of Educational Strategies Sales Development Representative MS, EdS Documentation Specialist Iannuzzi Associate Director of Professional Development Associate Director of Client Support Services PhD, MA, MEd Chief Academic Officer Manager of Client Educational Development System Architect and Co-Founder TRUSTED BY TOP MEDICAL SCHOOLS More client partners American Underground @ Main 201 West Main Street #308 Implementation Approach Standout Features Leo Integrations Leo FAQs Tech Teams ADRIALDESIGNS.COM

Llanbradach Follies artwork unveiled News | Richard Gurner | Published: 07:41, Friday December 18th, 2009. The Mayor joins members of the local community at the unveiling of the Llanbradach Follies. Two eye-catching five-metre high towers have been unveiled in Llanbradach. Artist Kay Aplin has created the spectacular towers called Llanbradach Follies and they have already become a landmark in the village since being unveiled by Councilor John Evans, the Mayor of Caerphilly County Borough Council. Covered in 2,000 brightly coloured tiles, the follies are based on the local imagery, history, culture and stories of the area. Llanbradach Councillor Colin Mann said: "The follies represent the finishing touch to the regeneration work in the centre of Llanbradach which has been ongoing for several years now. We are grateful to all the people who have worked very hard to bring about this improvement to our village." The artwork was funded by Llanbradach and Pwllypant partnership, The Arts Council of Wales and Caerphilly County Borough Council and was project managed by Caerphilly Arts Development. A spokesperson for Arts Council of Wales said: "This ambitious public art commission in Llanbradach had a strong community involvement as local people developed the themes for the final work with the artist, Kay Aplin. "We hope that the sculpture will become a much loved feature which will create a strong sense of pride and identity in the area." Ms Aplin said: "This is my biggest and most spectacular commission to date and one that will hopefully continue to inspire and delight the community of Llanbradach for many years to come. "It's been 18 months since I first began to design the towers, in conjunction with the local community, and I am very excited to see them finally being installed." What do you think of the follies? Let us know below.

California universities using SAT for admissions are violating civil rights, lawsuit claims By Li Cohen December 10, 2019 / 10:16 PM / CBS News The University of California is being sued for requiring incoming students to take the SAT and ACT. The lawsuit claims that the tests have a well-known "discriminatory effect" and "exacerbate the inequities" for underrepresented students. The lawsuit says the University of California (UC) is legally obligated to provide equal access to all students. The SAT and ACT, the lawsuit says, "reflect demographic and socioeconomic characteristics like family income, parental education and race" instead of measuring "academic ability or mastery of curriculum." The College Board, the organization behind the SAT, released a 2019 assessment of the SAT/PSAT in California that found 45% of white students scored 1,200 or above, while 12% of Latinx students and 9% of Black students got the same score. Parental education levels were also directly related to student scores — only 21% of test-takers whose parents did not receive a high school diploma met SAT benchmarks while 77% of those whose parents have graduate degrees met benchmarks. Royal Caribbean says video shows grandfather knew window was open Zoo offers revenge on your ex for Valentine's Day Investigation finds 47 dogs died after PetSmart grooming While UC does not have minimum test score requirements, applicants are required to take either the ACT with writing or the SAT exam. "Applications should keep in mind that when selecting students, competitive campuses and programs look for applicants who have excelled academically," its website states. The minimum average score for reading at the nine UC undergraduate schools is 580; for math the minimum average score is 579. White and Asian students are the only race demographics who met this standard in the 2019 report. The lawsuit was filed on behalf of six organizations and four students "whose ability to access public higher education has been hindered by UC's SAT or ACT score requirement." Public Counsel, the pro bono legal service representing the students and organizations, posted about the filing Tuesday on Instagram. They quoted attorney Mark Rosenbaum as saying, "... if the SAT means anything, it stands for 'Socio-Economic Advantage Test' — it is illegal." "Use of the SAT and ACT is not just indefensible policy - if the SAT means anything, it stands for "Socio-Economic Advantage Test" - it is illegal. It is illegal wealth and race discrimination that damages the futures of tens of thousands of deserving students each year who could excel at UC campuses of their choice and that are best suited to their strengths and passions. As this nation's preeminent public institution of higher education, the UC system has no more constitutionally sacred obligation than to ensure equal access to all of California's young persons, to serve as a beacon of hope and opportunity. By its reliance on the SAT and ACT, the UC system subverts this mission and makes its campuses havens for concentrated privilege." - Mark Rosenbaum, Directin ATtorney with Public Counsel. Why we filed a lawsuit against the University of California for discriminatory use of the SAT/ACT in admissions today. 🔹Link in bio to read the @npr story🔹#highereducation #educationrights #JusticeforAll #educationforall #standardizedtesting #SAT A post shared by Public Counsel (@public_counsel) on Dec 10, 2019 at 4:44pm PST One of the plaintiffs is 17-year-old Kawika Smith, a African American student from Verbum Dei High School. According to the lawsuit, Smith was homeless from second through eighth grade, is a rape survivor, experienced domestic violence and suffered from the loss of his brother his junior year of high school. These circumstances, the lawsuit says, prevented him from getting adequate test preparation and thus, was ineligible to be admitted to UC. Smith posted a photo of himself on Instagram, originally posted by Public Counsel, saying "the SAT score does nothing for people like me." "The SAT doesn't account for all the ways I'm stepping up as a leader in my community or how I'm healing from trauma and growing from my lived experiences," he posted. "And it doesn't say anything about how well I can do in college or whether I can achieve my dreams." #Repost @public_counsel "The SAT score does nothing for people like me. The SAT doesn't account for all the ways I'm stepping up as a leader in my community or how I'm healing from trauma and growing from my lived experiences. And it doesn't say anything about how well I can do in college or whether I can achieve my dreams." | Kawika Smith, senior at Verbum Dei High School. Basing college admissions decisions on SAT and ACT scores amounts to deciding students' future based on their race and socioeconomic status and not on individual merit. Today, on behalf of three students including Kawika, five nonprofits and the Compton Unified School District, our legal team including lawyers from Scheper Kim & Harris, Equal Justice Society, Miller Advocacy Group, and Olivarez Madruga Lemieux O'Neill, LLP​ announced our formal request to the University of California Board of Regents that the UC system cease use of SAT and ACT test scores in admissions decisions. The Board of Regents will have ten days to respond, and if the practice is not stopped, we will file a civil rights lawsuit against the UC for knowingly creating barriers to higher education for students of color and students with disabilities. A post shared by Kawika Smith (@kawika_smith) on Oct 29, 2019 at 5:20pm PDT This barrier, the lawsuit claims, violates the state's equal protection guarantees, state education laws and civil rights laws. More than 1,000 universities and colleges have removed the requirement from their application. "... [T]his policy illegally discriminates against applicants on the basis of race and wealth, and thereby denies them equal protection under the California Constitution," the suit claims. UC Berkeley chancellor Carol Christ said at a forum November 23 that using these standardized exams for college admissions decisions is unfair, according to The Associated Press. "They really contribute to the inequities of our system," Christ said. UC Santa Cruz chancellor Cynthia Larive reportedly said she also supports removing the testing requirement, according to AP. "At Santa Cruz, we use holistic admissions to try to evaluate the student within a broader context, which cannot be simply reduced to a number," she said. Since January, the university system's Standardized Testing Task Force has been looking at how standardized testing is being used for admission. No reports have been made available. First published on December 10, 2019 / 10:16 PM

Articles tagged with: The crossing The French prize of the Best Foreign Book was awarded to Yazbek's The Crossing yesterday! [30 Nov 2016 | 3 Comments | 265 views] This is a translation of an article by Gregoire Lemenager for Nouvel Observateur. The prize for the Best Foreign Book (Meilleur Livre Etranger), the jury of which includes critics and publishers, is awarded on 29 November. There are two awards, one for fiction and one for non-fiction. In the non-fiction category, the prize was awarded to Samar Yazbek's The Crossing. Yazbek's "Les portes du néant" ("The crossing") is on the shortlist of the prestigious French Médicis award There are 14 titles on the shortlist, and the winner will be announced on October 10th. The Prix Médicis aims at giving recognition to authors whose fame does not match their talent. The prize was awarded to authors such as Jean Echenoz, Philippe Sollers, Sorj Chalandon or Marie Darieussecq in the past. Earlier in the summer, Samar Yazbek was given the title of"Chevalier de l'Ordre des Arts et des Lettres", or "Knight of literature", by the French ministry of culture. This title is a sign of recognition of the services Yazbek … A "formidable" narrative – Le Monde des Livres honours Yazbek's The Crossing [21 Apr 2016 | No Comment | 146 views] Jean Hatzfeld for Le Monde des Livres, April 15 2016 Les Portes du néant, à la frontière turque, s'ouvrent une première fois sur la route qui mène à la région d'Idlib, dans le nord-ouest de la Syrie. Samar Yazbek les franchit en août 2012, en se faufilant dans un trou creusé sous des barbelés. Une voiture l'attend, qui traverse la nuit sur un fond sonore de bombardements, avec à l'intérieur Maysara et Mohammed, deux frères d'armes rebelles : ses anges gardiens. Le Nouvel Observateur: Yazbek's The Crossing "makes her comparable to Orwell" Gregoire Lemenager, for Le Nouvel Observateur, March 20th 2016 (…) She who until now scanned the gray areas of the good Damascene society in daring novels ( "Cinnamon" tells the homosexual relationship of a bourgeois with her housekeeper), then published "In the crossfire" (Buchet-Chastel, 2012) and collects literary awards that applaud her courage. Liberation draws Yazbek's portrait and reviews The Crossing, a "Colossal work" By Jean-Louis Le Touzet, for Liberation, March 20, 2016 Photo credit: Mathieu Zazzo, Liberation Men make war. But a woman, blonde, cat-eyed, 46-year old Syrian of high education was needed to paint Syria's death. No other brush was ever dipped in as many tears to tell the intoxication of brutality in a country under the yoke of a double punishment: that of a totally deranged regime and that of the unbearable cruelty of fanatical Islamists . To be clear, about Syria, we read everything and read nothing. Rarely such a plunging view of demolition was ever published. This is what this …

When you're adding an image, click the "Image Gallery" button to get started. In the "Image Gallery", you can simply click on an image you've used before to add it to the message. To delete an image from your gallery, first hover over the image in question.... I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive. Add anchors for linking Link back to an anchor In the Document window�s Design view, select text or an image to create a link from. select text or an image you want to link from. (If this is another open document, you must switch to it.) Do one of the following: Click the Point-To-File icon (target icon) to the right of the Link box in the Property inspector and drag it to the anchor you... While linked images have several downsides (discussed in this article), they can be used in cases where e.g. reducing the size of the email is a priority. Below you will find the steps necessary to override Outlook�s default behavior and force it to use a linked/internet image. It�s nice to spice up your transactional emails with a few images from time to time. Even if it�s just a logo, you�ll find it helps to add a touch of legitimacy to what you�re sending out. However, there�s no one way to do this. Do you link out to the image on a CDN? Do you embed it and... I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive. I have imported a HTML report into word by opening it (open index.html in Word) and copy / paste the result as an annex into my Doc. It worked fine, except that all the images (200 of them) are actually links to the images on my hard drive. 11/03/2015�� Right click on the image and add hyperlink. Copy the whole table with the image into your outlook message. Note, you may want to remove the border for the table before you copy it to your outlook message.

Dana Zátopková is 96 years old today; her celebrated husband, Emil Zátopek would have been 96 too, since by coincidence they were born on the same day, just a few hours and a hundred kilometres or so apart. Her status as an elder stateswoman of the sport seems to contrast with her beginnings; because apparently Dana was a bit of a tomboy in her youth, dashing around, according to her mother in the most unladylike fashion. But that dynamism (and her mastery of the popular songbook of the period) attracted Emil, and has doubtless contributed to her longevity. Equally, his unbelievably onerous training programme may have contributed to Emil's relatively early death, aged 78, in 2000. A real 'character' herself, most of her life Dana had to play second fiddle to her ebullient and talkative husband. But she had her own moments in the sun, not least when she won the Olympic javelin title in Helsinki 1952, just after Emil had won the 5000 metres, the second leg (between the 10,000m and the marathon) of his unrepeatable Olympic treble. Even then, Emil had won three golds to her one; and he joked that the 5000m only made it 2-1, and he needed that third victory to emphasise family superiority. But he went a step too far when he attributed her victory to himself. Her riposte is typical of the sense of humour which endures to this day. Here, beginning with the prelude to the 1952 Olympic javelin final, is the relevant extract from my book on Zátopek, QUICKSILVER*. '… The final of the women's javelin was due to begin concurrent with the 5000 metres, and as she (Dana) records, the last thing she needed was the sort of cliff-hanger finale that Emil had stage-managed so adroitly. 'That´s terrible, she wrote in their autobiography, 'That Ťopek (chohpek, his pet name) always makes it so exciting that the whole stadium is on its feet. When I see him chasing like that my knees are shaking. With that, I won't throw any distance at all'. 'I was trying to comfort her,' wrote Emil, 'telling her to stay calm, because she'd lost before and I wasn't going to win the 5000 metres anyway. At the finish I recognized, to my delight, my mistake. When I looked around the stadium, I didn't see either Dana or the other javelin throwers. We met in the changing room after the award ceremony. I wanted to ask why the javelin had been delayed but I couldn't get a word in edgeways. She jumped all over me, she was so thrilled. "You really won it! That´s wonderful! Show me the medal!" And there she was, putting it into her bag. For good luck, she said.

Home About us Contact InN Films (inn + film) Distribution by Scientific Domains Physics and Astronomy 100% Selected Abstracts Optical properties of InN grown on Si(111) substrate PHYSICA STATUS SOLIDI (A) APPLICATIONS AND MATERIALS SCIENCE, Issue 5 2010 E. Sakalauskas Abstract A comprehensive characterization of the optical properties of wurtzite InN films grown by molecular beam epitaxy on Si(111) substrates is presented. Two types of films are investigated in this work: InN on AlN/Si(111) and InN on GaN/AlN/Si(111). Their properties are compared to a layer deposited on GaN/sapphire substrate. The dielectric function (DF) is obtained from spectroscopic ellipsometry (SE). The infrared studies yield the plasma frequency and thus the electron density, while the interband absorption is probed between 0.56 and 9.8,eV. For InN grown on Si(111) substrate, the absorption onset is slightly shifted to higher energies with respect to the InN film grown on GaN/sapphire which can be attributed to higher electron concentrations. Despite this, strongly pronounced optical transitions due to critical points of the band structure are found in the high-energy part of the DF. It emphasizes the already promising quality of the InN films on silicon. Band-gap renormalization (BGR), band filling, and strain are taken into account in order to estimate the intrinsic band gap of wurtzite InN. For the InN layers on silicon, we get a band gap between 0.66 and 0.685,eV. [source] MOVPE of InN films on GaN templates grown on sapphire and silicon(111) substrates Muhammad Jamil Abstract This paper reports the study of MOVPE of InN on GaN templates grown on sapphire and silicon(111) substrates. Thermodynamic analysis of MOVPE of InN performed using NH3 as nitrogen source and the experimental findings support the droplet-free epitaxial growth of InN under high V/III ratios of input precursors. At a growth pressure of 500 Torr, the optimum growth temperature and V/III ratio of the InN film are 575,650 °C and >3 × 105, respectively. The surface RMS roughness of InN film grown GaN/sapphire template is ,0.3 nm on 2 ,m × 2 ,m area, while the RMS roughness of the InN film grown on GaN/Si (111) templates is found as ,0.7 nm. The X-ray diffraction (XRD) measurement reveals the (0002) texture of the InN film on GaN/sapphire template with a FWHM of 281 arcsec of the InN (0002) , rocking curve. For the film grown on GaN/Si template under identical growth conditions, the XRD measurements show the presence of metallic In, in addition to the (0002) orientation of InN layer. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Growth and properties of In-rich InGaN films grown on (0001) sapphire by RF-MBE PHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 12 2004 M. Kurouchi Abstract We have performed detailed investigations of the optical properties of strain-free In-rich InxGa1,xN (0.61 , x , 1.0) films that were grown directly on (0001) sapphire substrates by radio-frequency plasma-excited molecular beam epitaxy. In-composition dependence of photoluminescence peak energy for the InxGa1,xN films, measured at room temperature, exhibited a monotonic and smooth decrease with the increase in the In-composition, approaching to 0.66 eV of a strain-free InN film that was also grown directly on the sapphire substrate. The energy bowing parameter, b was determined to be 1.8 eV using these strain-free InxGa1,xN films. Structural properties of these films are also investigated in detail. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Analysis of the local structure of InN with a bandgap energy of 0.8 and 1.9 eV and annealed InN using X-ray absorption fine structure measurements PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 6 2006 Takao Miyajima Abstract We compared the local structure around In atoms in microwave-excited MOCVD- and MBE-grown InN film which indicates an absorption edge at 1.9 and 0.8 eV, respectively. The co-ordination numbers of the 1st-nearest neighbor N atoms and the 2nd-nearest neighbor In atoms for MBE-grown InN were n(N) = 3.9 ± 0.5 and n(In) = 12.4 ± 0.9, which are close to the ideal value of n(N) = 4 and n(In) = 12 for InN without defects, respectively. By thermal annealing, the structure of MBE-grown InN was changed from InN to In2O3, and the absorption edge was changed from 0.8 to 3.5 eV. However, the microwave-excited MOCVD-grown InN had no structure of In2O3, and had the reduced co-ordination numbers of the 2nd-nearest neighbor In atoms of n(In) = 10.6-11.7. From these results, we conclude that the origin of the 1.9-eV absorption edge of InN is the imperfections (defects) of the In lattice sites of InN, rather than the generation of In2O3, which has a bandgap energy of 3.5 eV. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Optical anisotropy of A - and M -plane InN grown on free-standing GaN substrates P. Schley Abstract Wurtzite A - and M -plane InN films were grown by molecular beam epitaxy (MBE) on free-standing GaN substrates. Spectroscopic ellipsometry (SE) in the photon energy range from 0.56 up to 15,eV was applied in order to determine the ordinary and extraordinary complex dielectric function (DF) of InN. A distinct optical anisotropy was found over the whole energy range. The extraordinary absorption edge in comparison to the ordinary one is shifted to higher energies confirming previous studies. The investigations in the upper vacuum-ultraviolet (VUV) spectral range (9.5,15,eV) yielded transition energies for four critical points (CPs) of the band structure (BS) which have not been observed so far. [source] Doping-dependence of subband energies in quantized electron accumulation at InN surfaces T. D. Veal Abstract Electron tunnelling spectroscopy is used to investigate the quantized electron accumulation at the surfaces of wurtzite InN with different doping levels. The tunnelling spectra of InN-oxide-tip junctions recorded in air at room temperature exhibit a ,0.6 V plateau, corresponding to the band gap of InN, and a gap between onsets of 1.3 V, consistent with the separation between the valence band maximum and the pinned Fermi level at the oxidized InN surface. Also observed within the tunnelling spectra are additional features between the conduction band minimum and the pinned Fermi level. These features are attributed to surface-bound quantized states associated with the potential well formed by the downward band bending at the InN-oxide interface. Their energetic positions are dependent upon the doping level of the InN films and coincide with calculated subband energies. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] High-quality InN grown on KOH wet etched N-polar InN template by RF-MBE D. Muto Abstract We have succeeded in dramatically decreasing the density of dislocations in InN by regrowing InN films on micro-facetted N-polar InN templates. The micro-facetted N-polar InN templates were formed by wet etching in a 10 mol/l KOH solution. InN films were regrown on the micro-facetted N-polar InN templates and on flat surface N-polar InN templates for comparison by radio-frequency plasma-assisted molecular beam epitaxy. InN regrown on micro-facetted InN had considerably smaller twist distribution than that grown on the flat InN templates. From transmission electron microscopy observation, it was confirmed that the InN grown on the micro-facetted InN template had much lower density of dislocations than that grown on the flat InN template, and moreover the propagation of edge dislocations was almost completely terminated at the interface between the regrown InN and the micro-facetted InN template. Based on the results, we propose that regrowth of InN on micro-facetted InN templates is an effective way to obtain high-quality InN films. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Stoichiometry effects and the Moss,Burstein effect for InN K. S. A. Butcher Abstract We examine the Moss,Burstein effect for InN and demonstrate an independent method for determing its magnitude for high carrier concentration material. Consequently it is shown that the extent of the Moss,Burstein effect is less than 0.72 eV for a high carrier concentration sample with a 1.88 eV absorption edge. Early results are also provided for high band-gap low carrier concentration InN films that can be grown reprodcibly, vindicating the work of early groups in the field. The role of stoichiometry is examined in relation to point defects that appear to be common to many forms of InN. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Raman and transmission electron microscopy characterization of InN samples grown on GaN/Al2O3 by molecular beam epitaxy PHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 7 2006 J. Arvanitidis Abstract Raman spectroscopy and transmission electron microscopy were employed to study the vibrational properties and the microstructure of epitaxially grown InN films on GaN/Al2O3 templates. The variations of the InN lattice constants, as deduced by electron diffraction analysis, along with the red-shifted E22 mode frequency reveal that InN films exhibit residual tensile stress, strongly dependent on the epilayer growth temperature. Threading dislocations are the dominant structural defects in the films, having a density in the order of 109,1010 cm,2. Profile analysis of the E22 Raman peak by means of the Spatial Correlation Model provides useful information concerning the effective mean length for free phonon propagation (L), which is a measure of the structural quality of the samples. In all the studied samples, L monotonically increases with decreasing threading dislocation density of pure screw and mixed type character. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Effective mass of InN estimated by Raman scattering PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 7-8 2010 Jung Gon Kim Abstract We have estimated the longitudinal effective mass (m,) of electron in n-type InN films by Raman scattering. The samples were grown by MOVPE (metal organic vapor phase epitaxy) with free carrier concentration of n =6.7×1018 -9.9×1018 cm -3 according to Hall measurement. A weak Raman signal observed at ,430 cm -1 at room temperature was sharpened and shifted to higher frequency toward the A1(TO)-phonon mode at 447 cm -1 with increasing n. This mode was assigned to the lower branch (L - ) of the longitudinal-optic-phonon-plasmon-coupled (LOPC) mode. The line shape was carefully analyzed by a semi-classical line-shape fitting analysis assuming deformation potential and electro-optic coupling mechanisms for the light scattering process. A line-shape fitting analysis was conducted by adjusting three major parameters; electron density, effective mass and plasmon damping rate. The analysis well reproduced values of electron density and mobility deduced by Hall measurement. Electron effective mass of m,*/m0 = 0.05 (±0.01) was also obtained as the best-fit parameter. The result agrees well with previous data obtained by other optical methods. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] RF-MBE growth of InN on 4H-SiC (0001) with off-angles Misao Orihara Abstract We have grown InN on 4H-SiC (0001) substrates with various off-angles by RF-N2 plasma molecular beam epitaxy (RF-MBE). Scanning electron microscope observation revealed that InN films grown on 4H-SiC (0001) substrates with off-angles of 4° and 8° are very smooth and that there are no voids which have often observed for InN epitaxial layers. X-ray diffraction reciprocal space maps for InN grown on 4H-SiC (0001) showed that the c-axes of InN grown on 4H-SiC 4° and 8° off substrates are inclined by 0.35° and 0.8°, respectively, toward the misorientation of the substrate while the c-axis of InN is parallel to that of 4H-SiC for the on-axis substrate. Strong PL peak was observed from InN grown on 4° off substrate at 0.68 eV at 15 K. The PL peak was clearly observed even at room temperature and simply shifted to lower energies with increasing temperature. The difference in the PL peak energy between at 15 K and 300 K was 20 meV, which is reasonable taking into account the difference in the thermal coefficients of InN and SiC (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Photoluminescence of cubic InN films on MgO (001) substrates T. Inoue Abstract We have studied photoluminescence from cubic InN films grown on MgO substrates with a cubic GaN underlayer by RF N2 plasma molecular beam epitaxy. A single PL peak was observed at 0.47 eV. By analyzing the reflectance spectra of cubic InN films, we could derive the refractive index and extinction coefficient, and found the band gap energy of cubic InN is 0.48 eV, indicating that the PL peak observed at 0.47 eV is due to the interband transition of cubic InN. The difference in the PL peak energy between hexagonal and cubic InN is in good agreement with that predicted by ab-initio calculations. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] NH3/TMI molar ratio dependence of electrical and optical properties for atmospheric-pressure MOVPE InN A. Yamamoto Abstract The electrical and optical properties for atmospheric-pressure MOVPE InN have been studied as a function of NH3/TMI molar ratio during the growth. Residual carrier (electron) concentration is decreased with increasing NH3/TMI molar ratio. PL peak energy is also shifted to a low energy side with increasing NH3/TMI molar ratio. Hall mobility of InN is almost independent on NH3/TMI molar ratio and is rather decreased at a high NH3/TMI molar ratio. The highest mobility is obtained for a sample grown at a relatively low NH3/TMI molar ratio. The grain size of the InN films is decreased with increasing NH3/TMI molar ratio. The lowest carrier concentration of 4.5×1018 cm,3 and highest mobility of 1100 cm2/Vs obtained here are the best data for MOVPE InN ever reported. Based on these results, the most probable candidate for donors and the dominant carrier-scattering mechanism for atmospheric-pressure MOVPE InN are discussed. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Growth of InN on 6H-SiC by plasma assisted molecular beam epitaxy April S. Brown Abstract We have investigated the growth of InN films by plasma assisted molecular beam epitaxy on the Si-face of 6H-SiC(0001). Growth is performed under In-rich conditions using a two-step process consisting of the deposition of a thin, low-temperature 350 °C InN buffer layer, followed by the subsequent deposition of the InN epitaxial layer at 450 °C. The effect of buffer annealing is investigated. The structural and optical evolution of the growing layer has been monitored in real time using RHEED and spectroscopic ellipsometry. Structural, morphological, electrical and optic properties are discussed. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]

DENVER (CBS4) – A school in northeast Denver had to be put on lockdown Monday afternoon while police looked for a man who was possibly armed with a gun. Harrington Elementary located at 2401 East 37th Avenue was on lockdown for approximately 10 minutes while police searched for the suspect. According to Sonny Jackson with Denver police, the suspect had pointed a gun at a group of people near the 3200 block of Dahlia Street. Harrington Elementary had been doing a planning day so no students were at the school. Police believe the suspect left the area and the search continues.

Home » Women » What You Need to Know About Meningitis What You Need to Know About Meningitis July 18, 2017 Igor Abolnik, MD Meningitis is a dangerous infectious disease that crops up year after year, much like the flu, and spreads very quickly. What do you need to know so you can protect yourself and your loved ones from this aggressive, potentially life-threatening disease? We spoke with Igor Abolnik, MD, an infectious diseases physician at St. Joseph Health Medical Group, to find out. Q. There have been regular reports in the news through last winter and spring about meningitis cases cropping up in both Northern and Southern California. For example, through July 7, 2017, ten cases of invasive meningococcal disease--including two fatalities--have been found in Los Angeles County this year, exceeding the previous five-year average. All but one of the cases occurred between January and March. Is this an outbreak that people need to be concerned about? A. There has definitely been an increase as compared to previous years. Last winter was harsher than usual, resulting in people staying inside more than normal. This meant people were spending more time in close contact with others and, because of the contagious nature of meningococcal meningitis, the disease spread very quickly. When you combine winter weather with people in close proximity, like a school or office, the risk of any infectious disease rises. Again, I would not consider these recent cases an epidemic. However, meningitis outbreaks--even if seemingly limited in scope--are serious public health concerns. When meningitis is afoot, as it was earlier this year, it is important to understand the nature of the disease, the symptoms, how it spreads, and how to protect yourself against it. Q. What are the different kinds of meningitis? A. There are five different types of meningitis; however, three are very rare. The two most common and basic strains are: 1. Bacterial: The first and most dangerous is bacterial meningococcal meningitis. It can be deadly, even if it's detected quickly. The bacteria get into the bloodstream and cause swift, widespread infection and inflammation of the brain and spinal cord. Bacterial meningitis proves fatal in 5-15 percent of people who contract it, even with prompt medical treatment. 2. Viral: Viral meningitis is more common and much less dangerous. Most cases stem from enteroviruses (which are transmitted through the intestines), measles, mumps, chicken pox or viruses from insects. In most cases, it resolves on its own within seven to 10 days without treatment. Q. How is meningitis most commonly spread? A. Bacterial meningococcal meningitis spreads very easily through direct contact, like coughing, sneezing or saliva transfer (such as kissing or even mouth-to-mouth resuscitation). Viral meningitis spreads most commonly through fecal contamination, or secretions of the eyes, nose or mouth. The best way to prevent viral meningitis is frequent and proper hand washing – and, of course, vaccination. You can't get either type of meningitis from casual contact or from simply breathing the air that an infected person has breathed. To become infected yourself, you have to have close and sustained contact with an infected person, or you have to share something with that person that can spread germs, like tissues, towels, lip gloss, makeup, eating utensils or drinking cups. Q. We're told that meningococcal meningitis symptoms resemble the flu – is this true? What are the primary symptoms of bacterial and viral meningitis? A. It's not accurate to say that the symptoms are the same, but people who have the flu might mistakenly associate meningitis symptoms as simply part of their flu. Meningitis is a potential complication of the flu, especially for people with asthma, diabetes or heart disease, but meningitis has its own set of recognizable symptoms: a sudden high fever, a stiff neck (which usually doesn't occur in flu), and mental confusion or other unusual changes in cognitive ability. Taken together, these are significant warning signs of a potential case of meningococcal meningitis, even more so if accompanied by nausea, bad headaches, rashes or pain all over the body. If you exhibit these symptoms, you should go to the emergency department immediately. Time is of the essence in treating meningitis. In fact, I recommend larger, urban hospitals rather than smaller, rural hospitals if you have the option. Facilities in large metropolitan areas tend to be better equipped and have a larger selection of medications on hand. This will give your doctors the quickest access to the widest range of antibiotics. You should also see your doctor right away if you've recently been in close contact with a person who has just had meningitis. Q: What is the treatment for meningitis? A. Antibiotics. I cannot stress enough how important it is to been seen by a physician and obtain the proper antibiotics without delay. Meningitis is a well-understood disease and full recovery is possible. However, the consequences of an untreated bacterial meningitis infection, even if not fatal, can include lifelong and disabling after-effects like hearing loss, sight problems and brain injury. Q. How can meningitis be prevented? A. There's no question that prevention is a crucial first step in keeping isolated cases from becoming an outbreak. First and foremost, you should protect yourself from all types of meningococcal meningitis with the appropriate vaccinations. Adults who have an immune system disorder, or who live in or travel to an area where meningitis is common, or who have been exposed to someone with meningitis, should be especially sure to ask their doctor about a vaccination. There is a new recommendation from the Centers for Disease Control and Prevention (CDC) for all men who have sexual relations with other men to get the meningococcal meningitis vaccination. There is also a vaccination available specifically for people with diabetes or who are over the age of 65. These people are at a higher risk of pneumonia and sepsis, which weakens the immune system and makes them more vulnerable to meningococcal meningitis. Second, you should not share items that can spread germs through saliva like food, drinks, cups, utensils or toothbrushes. Lastly, maintaining a healthier overall lifestyle can enhance your immune system's ability to protect you not just from meningitis, but a wide range of disease. Don't smoke, drink alcohol only in moderation, eat a nutritious diet, and exercise regularly. Q. How can I protect my children from meningitis? A. I'm an adult infectious disease specialist; however, the CDC recommends meningococcal vaccinations for all children ages 11 to 12, along with a follow-up booster shot at age 16. Ask your pediatrician or family doctor about the right immunization schedule for your kids. Children who are about to go to summer camp, for example, may need a meningitis vaccination due to the shared sleeping and dining arrangements. In addition to vaccination, you can help protect your kids from meningitis by teaching them good personal hygiene, like frequent hand-washing, and instilling the same habits that can keep their immune system healthy like they can yours, such as eating a balanced diet, getting plenty of sleep, and staying physically active. Q: How can I find out if I've been vaccinated? If not, can I get the vaccination? A. Your primary care physician can check your health records and tell you if you've received the vaccination. If you haven't been vaccinated, he or she can give you the vaccination right in the physician's office. Women who are pregnant or breastfeeding, and people with severe allergies, need to be medically cleared before receiving certain meningococcal vaccinations; but, in general, everyone can and should be vaccinated. Your doctor can advise you about which specific vaccines are right for you and when you should get them. No One Dies Alone Trained volunteers provide peace and comfort for dying patients when no one else can be there Arguing can improve relationships You may find this strange, but having it out with your partner may actually be the key to a successful rela... Spotlight on our Women & Children's Clinical Institute The Institute ensures that patients receive greater gynecological health, safer deliveries and healthier newborns. 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2019 STEM Institute – Keynote Speakers – NYS STEM Education Collaborative, Inc. advancing sustainable energy solutions and environmental technology innovation. In June 2017, Gov. Andrew Cuomo nominated President Collins to sit on the board of trustees of the NYS Higher Education Services Corp. (HESC) as a representative of private higher education and was approved by the New York Senate in June 2018. New York State's higher education student financial aid agency. In May 2014, President Obama nominated Dr. Collins to serve on the Advisory Board of the Saint Lawrence Seaway Development Corporation. NY Governor Andrew Cuomo appointed Dr. Collin to serve as co-chair for the North Country Regional Economic Development Council from July 2011 – February 2019. Dr. Collins served on a commission, established by Governor Cuomo in November 2012 to investigate and study utility companies' storm preparation and management; and to recommend reforms to overhaul regulation of the entire system to better deal with emergencies. He is the also the president of the Seaway Private Equity Corporation that invests in new technology companies based in St. Lawrence County, New York; and is a member of NYSERDA's Technology & Market Development Advisory Committee which provides technical and policy guidance to NYSERDA on energy and environmental research and market development initiatives. In service to the higher education sector, President Collins is the past chair of the National Association of Independent Technological Universities and a chair emeritus of New York's Commission of Independent Colleges and Universities. In addition, he serves on the boards of the CenterState Corporation for Economic Opportunity and the NYS Business Council. Robert Rogers is a SUNY Distinguished Teaching Professor of Mathematics in the Department of Mathematical Sciences at SUNY Fredonia. His original area of research is Operator Theory, but he has since focused more on applying the history of mathematics to the teaching of mathematics. He is also interested in bringing more STEM applications into mathematics courses. He is coauthor (with Dr. Eugene Boman, Penn State – Harrisburg) of the open source real analysis textbook "How We Got from There to Here: A Story of Real Analysis" available through the SUNY Open Textbook Program. He is a past chair and governor of the MAA – Seaway Section, a past president of the Association of Mathematics Teachers of NYS, and a member of the governing board the NYS STEM Education Collaborative. He is former editor of the NYS Mathematics Teachers' Journal. He is a recipient of the SUNY Fredonia President's Award for Excellence in Teaching, the MAA – Seaway Section Clarence F Stevens Distinguished Teaching Award, and the MAA Distinguished Service Award – Seaway Section. He is a member of the NYS Mathematics Educators' Hall of Fame. Dr. Kristina M. Johnson joined The State University of New York as its 13th chancellor in September 2017. Immediately prior to joining SUNY, Dr. Johnson was co-founder and CEO of Cube Hydro Partners, LLC, a clean-energy infrastructure company focused on building and operating hydropower plants in North America. She also previously served as Under Secretary of Energy at the U.S. Department of Energy. Dr. Johnson served as provost and senior vice president for Academic Affairs at Johns Hopkins University from 2007 to 2009, and as dean of the Pratt School of Engineering at Duke University from 1999 to 2007. Dr. Johnson received her BS, MS, and PhD in electrical engineering from Stanford University. After a NATO post-doctoral fellowship at Trinity College in Dublin, Ireland, she joined the University of Colorado-Boulder's faculty in 1985 as an assistant professor and, later, full professor. Among her many awards and distinctions, Dr. Johnson received the Dennis Gabor Prize for creativity and innovation in modern optics (1993) and the John Fritz Medal (2008), widely considered the highest award in engineering. Dr. Johnson is a member of the National Academy of Engineering, the National Academy of Inventors, and the National Inventors Hall of Fame. She holds 118 U.S. and international patents and has five honorary degrees.

Scottish Independence: Yes Voters and Salmond Constantly Misquote My Oil Figures says Sir Ian Wood By Lianna Brinded September 15, 2014 11:55 BST Scotland\'s First Minister Alex Salmond poses for a selfie with a fan, as he stands with local pop stars during an event in Edinburgh, Scotland September 14, 2014 Reuters Sir Ian Wood, one of Britain's most prominent oil and gas figures, has slammed the Scottish National Party and its leader Alex Salmond for repeatedly misquoting him on reserve estimates and therefore skewing the argument for independence. Wood, who says the SNP's oil reserve claims are around 45% to 60% too high, said while he is not political, he felt he has to speak out, as the Yes campaign and Salmond had consistently misquoted figures from his independent review that was released earlier this year. "I was drawn into this [discussion] because they were misquoting figures from my own review," said Wood in the Daily Mail. "I am thoroughly Scottish, but also thoroughly British. This referendum vote is forever, there is no going back. This vote is not for this generation – I'm 72 for goodness sake. Scottish Independence: Yes Vote Nationalism is Based on Racism and Hate says Philip Kerr Scotland\'s Job Market Continues Surge Through August Scottish Independence: SG Warns Yes Vote Will Create \'Massive Political Recriminations\' and Prompt \'Brexit\' Scottish Independence: ICM Poll Puts \'Yes\' and \'No\' Campaigns Neck and Neck Scottish Independence: 68% of Small Businesses Worried About Union Break Scottish Independence: Will the English Scots Save the Union? Scottish Independence: Make Money By Buying Discounted Investment Trusts on Union Break say Analysts Scottish Independence: Nick Clegg Backs \'Radical\' North England Devolution Plan "It is for my children, for my grandchildren. I want them to live in a Scotland where youngsters have a chance of a good job and of being prosperous. The best chance they have of that is as part of a strong United Kingdom and get the best of both worlds." Scottish people will vote in an independence referendum on 18 September, 2014, and will be asked the straight "yes/no" question: "Should Scotland be an independent country?" The Scottish government claims there are 24 billion barrels of oil left in the North Sea while Wood stipulates that there are in fact only 15 billion to 16.5 billion barrels of recoverable oil left. In keeping with the pro-independence campaign's oil production claims, N-56, which was founded by a member of the advisory board for Yes Scotland Dan Macdonald, North Sea revenues are pegged to be as high as £365bn (€456bn, $605bn) by 2041, if a series of recommendations were implemented. However, the UK Office for Budget Responsibility (OBR) forecast is at £61.6bn between 2013/14 and 2040/41. "Young voters must be aware that by the time they're in their 40s Scotland will have little offshore oil and gas production and this will severely hit our economy, jobs and public services," said Wood. "The N-56 report is an insult to the Scottish people. That gets my back up, it's just pie in the sky. How can people make a critical decision on the basis of this kind of nonsense?' he says. 'It is a blatant attempt to manipulate voting sentiment." Wood added that Salmond's claims that oil revenue would cover free prescriptions, university tuition and other issues, is wrong and that Scots should be wary of his claims. "If you produce 200,000 barrels a day for the next 15 years, you will not have enough income. So how does the Scottish government then propose to fill this gap?" he added. Related topics : Scottish Independence

One Man; Over 1300 Public Buildings: James Barnet Written by jml297 Scottish born James Barnet was the Colonial Architect of New South Wales from 1862 to 1890. Under his guidance, the architectural and civic landscape of the state changed and developed a confidence and character that is still evident today. These were boom years for the colony with the upgrade and replacement of early infrastructure as well as new buildings to meet the demands of a growing population. Goulburn Court House The length of tenure contributed to the sheer volume of buildings that were designed and constructed during these years. Many public buildings remain with alterations and in some instances perform a different purpose to their initial intention. But there is a style to these buildings which, once recognised, can be found in various city suburbs as well as many towns in regional parts of the state. Bathurst Court House Barnet was a classical, revivalist architect. Born in Scotland, he trained as a builder and stonemason before attending night school in London in order to attain his qualifications as an architect. Encouraged by a mentor, Barnet decided to migrate to one of the colonial outposts as there was an oversupply of architects in England at the time. In 1854 he migrated to Sydney with his wife, Amy. Lithgow Court House Similar to Scottish bridge-builder Lennox decades before, Barnet's potential was recognised whilst he was working on a building site as a stonemason. After a series of commissions he joined the Colonial Architect's Office in 1860. Two years later he was acting in the position of Colonial Architect, a position he held until 1890. Katoomba Court House The scope of work was wide and the quantity of buildings constructed was considerable. This included 169 post offices, 130 court houses, 110 goals and lockups, 155 police stations, 20 lighthouses, an extension to the Australian Museum, the Colonial Secretary's Office and the Lands Department building. These examples provide an insight into what was of importance at the time: communication, justice, transport and administration. Military defence and naval infrastructure were included in Barnet's remit, along with the maintenance of other public buildings. Dubbo Court House Barnet also designed the psychiatric hospital at Callan Park which opened in 1883 as the Hospital for the Insane. It consisted of 20 neoclassical buildings for the care of over 600 patients, male and female. The design was influenced by theories of the time which recommended high ceilings in a park like atmosphere. Callan Park building One of Barnet's most extravagant buildings was short-lived: the Sydney International Exhibition Building. Located adjacent to the Sydney Botanical Gardens on 5 acres, it was constructed in the spirit of the international exhibitions of the northern hemisphere and when complete was the largest exhibition space in the southern hemisphere – Melbourne was also striving for this title. The first electric light in Sydney was used to speed the building's completion as work continued around the clock. Over a million people came to the 'Garden Palace' to see the exhibition, quite amazing as the population at the time was just over two million. The building cost over three times its initial estimate and unfortunately was destroyed in a huge fire. Only a set of gates remain, located in Macquarie Street opposite History House. Goulburn Post Office Over his long career, Barnet served 16 ministers and oversaw the construction of over a thousand buildings. Despite similarities between buildings, templates as such were not used. Local materials and resources were used where possible. There were various parliamentary enquiries during his career and when he was finally forced to resign it was an ignominious professional end. Barnet was the last Colonial Architect as the office was restructured following his departure. Many of his buildings remain today and as I travel about I like to keep an eye out for Barnet's touch in public buildings as I go. Inspired by an excellent talk given by Emeritus Professor Don Napper. Australian Dictionary of Biography entry on James Johnstone Barnet. There is an extensive post about the prolific buildings designed by Barnet, particularly across the central west of NSW here. [Photo: detail from Dubbo Court House] March 27, 2017 March 26, 2017 · Posted in Mountain life · Tagged architect, Barnet, Callan Park, colonial history, Garden Palace, rural NSW, Sydney · 8 thoughts on "One Man; Over 1300 Public Buildings: James Barnet" such history and beautiful architecture… jml297 says: Thank you. I found the buildings in Goulburn by chance last week and was rather enchanted by both the courthouse and post office. They were buildings designed to make an impression. Thanks for your feedback 😊 I love architecture and these buildings are some of my favourites now that you have introduced me to them. Great photo's. Thank you. I'm glad you liked them. For me, architecture is like art – I know what I like without really being able to articulate why it appeals to me. Perhaps with Barnet it is the familiarity of his work as there are buildings in many of the country towns and suburbs I have been through. I'm glad you enjoyed the photos too 😊 Gail Kaufman says: These majestic buildings are impressive! Thank you, Gail. Many of them are located in regional areas and small towns, which make them all the more surprising when you come across them. 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Southern Ports Authority, Port of Esperance On the 1 st October 2014, the Esperance Ports Sea and Land merged with the Bunbury and Albany Port Authorities to form the Southern Ports Authority. The Esperance Ports Sea and Land is now known as the Southern Ports Authority, Port of Esperance. u The Southern Port Authority trading as SPA is a statutory authority created under the Ports Legislation Amendment Act 2013 and is subject to the Port Authorities Act 1999 (amended) and Port Authorities Regulations 2001. The SPA operates as a Government Trading Enterprise and has control of the Port of Esperance. u The Port's primary role is to facilitate trade, to support the industry in this function, operate in a safe and efficient manner and return a dividend to the Government of Western Australia. u The Port consists of three operational berths Berth 1 is a land backed berth used exclusively for exporting grain products. The Port is currently looking at constructing an additional pipeline at Berth 1 to allow for the discharge of fuel. Berth 2 is a multi-user land backed berth importing sulphur and fertiliser in bulk form and fuel. Exports from berth 2 include mineral concentrates in containers and in the near future, woodchips. Berth 3 is an isolated marine structure known as a dolphin style berth and is dedicated to exporting iron ore sourced from the Goldfields region. Buy Local Policy u The Port of Esperance has an internal Buy Local Policy which aims at supporting business through procurement of a variety of goods and services. u Why Buy Local? The Port of Esperance believes in supporting the township of Esperance and the region as a whole u Procuring locally & within the district ensures continuity of service and the economic benefit to the region. Goods & Services Sourced by the Port The Port of Esperance source a variety Personnel, Goods and Services which include: Ø Ø Ø Ø Manufacturing & Engineering Services Industrial Cleaning & Sweeping Services Machinery & Equipment Hire Information Technology Specialists Corporate and Administration Services Rail Contractors Mobile Plant Maintenance & Subcontractor Services Marine Maintenance Providers External Training Providers Accommodation Services Providers Trades including Plumbers, Electricians, Carpenters and Builders Finance and Insurance Providers Local Retail and Wholesale Business' Professional and Technical services. Regional Benefits The Port of Esperance provides an opportunity for the mining and agriculture sector to also contribute to the local economy through the facilitation of their trade. Upcoming Port Projects Among numerous projects being developed at the Port of Esperance, a number of major projects have been identified and approved within the Port's capital budget: Ø Ø Ø Hughes Road Upgrade – $5 - $11 M Iron Ore Shed Ventilation Upgrade Construction of a Container Hardstand Area Berth 1 Pipeline Project – up to $1 M Heavy Haulage Transport Services Front End Loader Contractor *Projects will be subject to a tender procurement process. Multi User Iron Ore Facility Ø In May 2014, the Yilgarn Esperance Solutions (YES) consortium was named as the preferred proponent to design, build and operate the new Multi User Iron Ore Facility valued at $200 M. Ø The consortium will finalise the design in conjunction with SPA prior to reaching financial close that is due within 18 months of contractual close. Ø Works will be tendered primarily by the YES consortium. Looking into the Future u The Port of Esperance continues to grow in trade and over the next few years and is expected to double the amount of iron ore currently being exported via berth 3 to a very productive 20 million tonnes per annum. u The discovery and re-commissioning of mineral deposits may see the current mineral concentrate exports increase from 216, 000 tonnes per annum to potentially 400, 000 tonnes per annum. u In the second quarter of 2014, the Port of Esperance will see it's first ever trial of woodchip product exported using a mobile ship-loader across berth 2. u In 2013 -14 the Port handled two Post Panamax sized vessels. The CMB Medoc sailed with 78, 636 tonnes of grain and was the largest grain shipment to ever leave Western Australia. u In 2014 the Port completed maintenance dredging of the inner harbour and channel, removing 68, 000 cubic metres of sand restoring the Port to the original design depth and allowing vessels to load additional product.

grandMA3 MA Network Switch MA Dimming Scancommander Lightcommander MA DMX Devices + Others MA University grandMA3 Basic Training grandMA3 Transition Training grandMA2 User Training grandMA2 Advanced User Training MA System Operator Training MA System Specialist Training dot2 User Training Fixture Shares MA Worldwide #stayhomeandlearn #handforahand Counterfeits: No Tolerance MA Distributor-Area A tale of love and life grandMA2 Rocks on Tony Award-winning "Hedwig and the Angry Inch" © Joan Marcus "Hedwig and the Angry Inch," the unconventional rock musical that recently captured four Tony Awards, may not be your grandma's Broadway show, but its use of grandMA2 lighting consoles keeps the edgy production on track at the Belasco Theatre. "Hedwig and the Angry Inch" is John Cameron Mitchell and Stephen Trask's gender-bending musical tale of life, love and a botched operation. It won Tonys for its star, Neil Patrick Harris; co-star Lena Hall; and lighting designer Kevin Adams – Adams's fourth win. The play also received top honours as Best Musical Revival. The lighting and video for "Hedwig" were programmed on two grandMA2 full-size consoles. During rehearsals Kevin Adams, video designer Ben Pearcy, associate lighting designer Paul Toben and second assistant lighting designer Jimmy Lawlor used grandMA onPC stations to monitor the production. Now, both lighting and video run nightly on a single grandMA2 light with an MA onPC command wing and an MA NPU (Network Processing Unit) as backup in the compact booth. Brian Dawson is the board operator. "grandMA2 offered us a really good networking solution that enabled us to have multiple programmers on the system during rehearsals and give display feedback for the designers," says lighting programmer Benny Kirkham; Zach Peletz is the video programmer. "The show is very dynamic and we had to get it done quickly. Using grandMA2 and all its tools was the only choice to get the look we wanted." Kirkham notes that the show "is supposed to depict a one-night-only concert by a punk rock group, so we had to create some of the insanity of that with the design. Kevin really walked the line well creating a show that's wild and anarchic without creating a distraction. The whole package comes together, and everything in the design works perfectly!" Adams met Kirkham on the new Blue Man Group show at the Monte Carlo in Las Vegas where they worked on a grandMA2 console. They reunited for "Hedwig," and Adams was "delighted" to partner with the programmer and the grandMA2 again. Adams liked grandMA2's graphical "Magic Sheets on the monitors," which meant he "never needed any paper" to speed up recalling control channel numbers. "I had a lot less info in front of me; I never needed any channel numbers. I could just point to the layout that Benny and I shared. It was very visual and intuitive. An entire layer of frustration went away." Adams also liked the colour monitors. "With 'Hedwig' we have mostly moving lights. With the monitors in colour it was easier to understand what was happening live." Kirkham notes that Adams "became quite a fan of the grandMA2" during the course of "Hedwig's" production. "It's fast and has the best effects engine on the market, which enabled us to create the look and feel we wanted," he says. "The grandMA2 was great at managing tracking and cue data – and there's no board that can fire up the popcorn machine as well as grandMA2 can!" Kirkham says he's never been involved in a production as "collegial" as "Hedwig." "Every change moved the show to an even better place," he reports. "We're very proud of it." "I've enjoyed working with Benny and the grandMA2 very much," Adams concludes. PRG supplied the lighting equipment. A.C.T Lighting, Inc. is the exclusive distributor of MA products in the USA and Canada. Used equipment: 2 x grandMA2 full-size 1 x grandMA2 light 1 x MA onPC command wing 1 x MA NPU (Network Processing Unit) "It's an amazing system" Phantom of the Opera debuts in Quebec with grandMA3 Phantom of the Opera has been an international phenomenon for more than 30 years. Now, the French concert version of the hit musical has debuted in Montreal and Quebec City where lighting designer... Project of superlatives MA Lighting for the Elbphilharmonie In January 2017, the Hamburg Elbphilharmonie was ceremoniously opened featuring a stunning building design by the Swiss architects Herzog & de Meuron. This marked the beginning of a new chapter in the... grandMA2 for Land of Kalevala A celebration of Finnish history Land of Kalevala is currently being staged at the Finnish National Opera, with set, projection and lighting designed by Mikki Kunttu. The performance is about Finland in which the epic 19th century... grandMA2 performs at Jiangsu Centre for the Performing Arts Reliability and flexibility praised The Jiangsu Centre for the Performing Arts, located at the Olympic Sports Center in Jiangsu Najing, is the largest modern theatre in China second in size only to the National Grand Theater located in... La Traviata staged at Joburg Theatre with grandMA2 "It is easy, fast and never crashes" Simon King is flying solo after working at the State Theatre in Pretoria for 28 years. He recently took a seat behind a grandMA2 full-size to light La Traviata, a stirring love story brought to The... MA Merchandising MA Lighting International GmbH An der Talle 24-28 [email protected] Phone: +49 52 51 68 88 65 10 Copyright © 2021 MA Lighting International GmbH

All 70 Posts in the Category: Music TV: The TV season is changing over. Of the shows I watched, Season 2 of Star Trek: Discovery wrapped up this week and The Orville has its season finale next week. Big Bang Theory would normally be ending around now, but it's the end of the series and they've scheduled their final one-hour episode in mid-May. And of course, Game of Thrones is back! As is another season of The Amazing Race. + GoT Season 8. From a little over 2 million viewers for its series premiere, to over 12 million for the Season 7 finale (at the time of airing), the world's most expensive TV show ($850m to make!) starts its final run. Apparently there is a 40 minute battle scene in an upcoming episode… + TAR is getting tired as a format, but my wife and I continue to watch it out of tradition. + Discovery flourished this season. As a die hard Trekkie, I found Season 1 really tough to digest given that it was meant to be canonical (why have we not heard about the mycelial network or Discovery or Spock's sister before?). But Season 2 papered over the cracks in the timeline enough to satisfy me. I also found the idea of bringing in some key characters only for a season interesting (like Anson Mount's Pike and Ethan Peck's Spock). Now it looks like the Discovery is 930 years in the future. I have been waiting for a new Trek franchise to be set further in the future for a couple decades now, so this is an exciting turn. + Trek seems to be getting a lot of spinoffs. There's Picard's new series, Georgiou's new Section 31 series, and now talk about a Pike spinoff. Oh, and there's Short Treks. Music: This is the best cover of Dire Straits' Sultans of Swing like, ever. 9:53am • Music • TV • Tweet This • Add a comment • What is this, I don't even (Korean edition) Try looking away. You can't, can you? This thing has over 32 million views. 10:49pm • Music • Tweet This • Add a comment • Paul Simon at the Fillmore Like the scent of a ex's perfume, some songs or artists trigger memories of certain past events in our lives. Paul Simon's music reminds me of a particular period in my life which came with a lot of mixed feelings. That added something extra to the performance, which was highly enjoyable. And interesting. Mr Simon is pushing 70 and the crowd at the Fillmore tonight was aged to match. The median age of the audience must have been in the 40s, but there were younger people there too – but it seemed that the older folk were getting stuck into the music a lot more. We were standing next to a man in his 40s and someone who appeared to be his father. The music had clearly triggered some memories for the father. Age had reduced his dancing to violent jerking and spasming, but he was clearly enjoying losing himself in the music (in between liberal drags of a few joints being passed among his family members). A friend said to me: "I don't think I've ever been to a concert where so few people have their phones in the air." Paul Simon started pretty promptly at 8.30pm. The old man still has his voice and enough energy to put on a great 140 minute performance, mixing some old classic standards with songs from his new album and a couple of covers. Catch him while you still can – he's worth it. 1:04am • Music • Tweet This • Add a comment • Three moving capos Trace Bundy plays a song on his acoustic guitar with three moving capos: See also this song, where he uses 5 capos. And here's a clip of him playing Pach's Canon with Korean wunderkind Sungha Jung. New OK Go MV – timelapse & slomo OkGO has another video out and this time they play with time. Very cool, as usual: "The fastest we go is 172,800x, compressing 24 hours of real time into a blazing 1/2 second. The slowest is 1/32x speed, stretching a mere 1/2 second of real time into a whopping 16 seconds. This gives us a fastest to slowest ratio of 5.5 million. If you like averages, the average speed up factor of the band dancing is 270x. In total we shot 18 hours of the band dancing and 192 hours of LA skyline timelapse – over a million frames of video – and compressed it all down to 4 minutes and 30 seconds! Oh and don't forget, it's one continuous camera shot." What passes for an "old classic" today "I think that's the great thing about Glee. Old classics like this get rediscovered by teenagers." – comment on Youtube, referring to Madonna's Vogue video. "Old classics?" Ugh, I feel old. I was in primary school when that song came out and remember watching the music video on Video Hits. I was too young and thought it was a pretty weird clip. But now I think it's pretty cool. OK Go – This Too Shall Pass (RGM version) In one flawless take. Truly impressive. This is the RGM version. The original is here. When karaoke turns homicidal The NY Times has an article about how several people singing Sinatra's "My Way" have been killed in the karaoke bars of the Philippines. Not while singing any other song. Just while singing "My Way". The killings have produced urban legends about the song and left Filipinos groping for answers. Are the killings the natural byproduct of the country's culture of violence, drinking and machismo? Or is there something inherently sinister in the song? Whatever the reason, many karaoke bars have removed the song from their playbooks. And the country's many Sinatra lovers, like Mr. Gregorio here in this city in the southernmost Philippines, are practicing self-censorship out of perceived self-preservation. The article also describes one creative method Filipinos have used to diffuse potentially lethal tensions in certain karaoke bars: A subset of karaoke bars with G.R.O.'s — short for guest relations officers, a euphemism for female prostitutes — often employ gay men, who are seen as neutral, to defuse the undercurrent of tension among the male patrons. Since the gay men are not considered rivals for the women's attention — or rivals in singing, which karaoke machines score and rank — they can use humor to forestall macho face-offs among the patrons. 12:01am • Music • Tweet This • Add a comment • Virtuoso pianist Last year, 21 year old Nobuyuki Tsujii won the 2009 Van Cliburn International Piano Competition, tying with Haochen Zhang. The pieces he performed for the competition included Chopin's Twelve Etudes, Liszt's La Campanella, a couple of Beethoven's Sonatas, Liszt's Hungarian Rhapsody No. 2 (below) and Rachmaninoff's Piano Concerto No. 2. Nobuyuki Tsujii was born blind. Some Michael Jackson humour: CSI's take on it. Oh, Wikipedia…. This isn't funny, but its ironic. 11:21pm (GMT -7.00) • Music • Tweet This • Add a comment • … suggestions for good music for a road trip. 3:42pm (GMT -8.00) • Music • Tweet This • Add a comment • U2 at Telstra Stadium Fantastic concert! Had to wait a year before they finally came, but I don't think anyone was disappointed! Set list for the night. Crowd shot Another crowd shot "Coexist": I think this was put up around the time Sunday Bloody Sunday and Miss Sarajevo were played Aussie flag sans Union Jack: U2 were probably playing to the right demographic for that political statement Everyone waving their mobile phones in the air: doesn't come out very well in the pic, but the effect was cool I thought it was a better show at Madison Square Garden in New York, but that was probably because it wasn't open air and was a more "intimate venue" where Bono could interact with the crowd a lot more (it ran longer, Bono chatted a bit more, guest appearance by Mary J Blige for One, a few audience members were dragged on stage to help sing, etc). But on the other hand, Telstra Stadium did have 75,000 people, and that creates quite an atmosphere. 8:02pm (GMT +10.00) • Music • Tweet This • Comments (4) • Jaxter Artist Awards The Jaxter Awards are now in their third year of running and there's more than $9000 worth of cash and prizes available. This year the competition has two sections: one for music composition and another for graphic design (of a CD cover). Know someone who's handy with an instrument or Photoshop? Get them to enter. 11:49am (GMT +10.00) tomorrow • Music • Tweet This • Add a comment • What's that tune? Can anyone tell me what the tune is on the Pepsi Max ad where a bunch of people jump in a dumpster, go tearing down the street, off a wharf and into Sydney harbour and go rafting? It sounds like it's from an old tv series, but I'm not sure what… And while we're on the topic of ads, that new Nike soccer ad is pretty cool, especially the bit where Ronaldinho gets taken out by the ref at the end. 10:28pm (GMT +10.00) • Music • Tweet This • Comments (3) • Michael Bublé Concert Went to see Michael Bublé's final Sydney concert with Denise and Jenny on Friday evening. When you fork out dosh to see a live performance, you're really there to see the performer perform – not just a repeat of what's out on their latest CD. Michael Bublé is great with the crowd and a surefire hit with the girls, at one stage jumping into the crowd to steal a kiss or ten from a particularly good looker in the front row. Her boyfriend took it in stride and ended up cuddling Michael. The girl, finding herself suddenly ousted from the action, leapt back in and threw her arms around the two of them, making it a threesome. (As Eddie Murphy said in his classic Delirious: "Being a comic though ain't like being no singer. The singers get all the pussy.") More photos here Most of the stuff was from his CD (including two of my favourites, That's All and The Way You Look Tonight), with some other great pieces thrown in. There were also a few short bursts of George Michael and Michael Jackson thrown in for laughs (no moonwalk, but he did sing Moondance). Good mix of slow and snappy songs. At the end he stepped away from the microphone and gave an acoustic rendition of a verse from My Funny Valentine. The hall slightly echoed his voice giving it a really rich, resonant quality. I don't know what it's called if it has a technical label, but like all good singers, he has the ability to finish off a line holding a sharp, crisp note that gently introduces a softly pulsating vibrato before gradually fading away cleanly. Terrific stuff. Another view from a concert-goer at Kazzart. 1:10am (GMT +10.00) tomorrow • Music • Tweet This • Add a comment • Soup Plus I've known about Soup Plus for years, but I've never gone until last Tuesday. It's a place that plays jazz nightly from 7pm with a bar and restaurant. It's an aging, but cosy little venue down some stairs on George St near the old Strand arcade. We saw the jazz trio (drums, double bass, piano/vocals) of Brendan Clarke, John Harkins and Andrew Dickeson on the night. Excellent stuff. $5 cover charge on Monday to Thursday nights. The food is fairly affordable, and a great place to chill out if you like jazz. Especially if you've had a hard, longish day at work and don't feel like going home to cook. Just bought tickets to see the last Michael Bublé concert at the Opera House. Should be good. I'd also pay to see James Darren but I don't think he'll be coming to Australia any time soon. He'd make a good convention guest for Holodiction, actually. 12:56pm (GMT +11.00) tomorrow • Music • Tweet This • Add a comment • Michael Jackson, King of Pop and alleged child molester, may be about to have another horrible year ahead, but the moonwalk is still cool. Here are some instructions on how to replicate it. Sounds like you'd have to wear out several pairs of socks before you can perfect it haha. 12:01pm (GMT +11.00) tomorrow • Music • Tweet This • Comments (2) • Finally! I got all ten volumes of Cafe Del Mar, plus the 20th anniversary set. Go BitTorrent! (Yes, I am still on 28.8k dialup. Yes, it did take a painfully long time.) Still need the chillhouse mixes and a couple other ones though. My favourite is still Volume 7. Jose Padilla's stuff is the best. Bruno's selections (Vols 8, 9) are rubbish, although Volume 10 does manage to redeem him. 3:31pm (GMT +10.00) tomorrow • Music • Tweet This • Comments (2) • Matchbox 20 Concert MB20 was absolutely fantastic. After a couple of very tepid supporting bands, Rob Thomas and his crew came on stage and kept the crowd going wild for almost two hours. Just about all the band's hits were done, both new and old (I only noticed that "Girl Like That" was missing). The tempo was mixed, with the few traditional rock songs spaced out with slower piano pieces. "If You're Gone" was done unplugged, although it felt emptier, missing the brass that fills in the gaps in the album version. "Downfall" was also missing the gospel choir, but a choir would have been a bit troublesome to bring along with them! I was also hoping to hear "You and I and I" which they only seem to play live, but unfortunately no luck. Nonetheless, excellent stuff. Good to sing along with, good to move along with. If you like MB20, I highly recommend seeing and hearing them in concert. Set List: Cold, Real World, All I Need, Soul, Disease, Could I Be You, 3 AM, Mad Season, Feel, Hand Me Down, If You're Gone, Bright Lights, Bent, (Cover), Unwell, Back to Good, You're So Real, Downfall, So Sad So Lonely, Long Day, Push. Click above for more photos (600kb) 1:17am (GMT +10.00) tomorrow • Music • Tweet This • Comments (4) • What Song? Brownie points if anyone can track down the female artist/band that covered The Beatles' "All My Loving" – the version played at the end of 2-DAY FM's Hot 30 show (with Kyle and Jackie O) each night just before the greets and shoutouts. I haven't managed to turn up anything. Digital Music Piracy SMH Article: "The record industry says it is disturbed by a study showing more than half of young Australians are unaware that "burning" music CDs and swapping songs online is illegal." For heaven's sake, if that is surprising to ARIA, the execs there are severely out of touch with society. Even for the older generation, having kids should be notice enough that music piracy is rampant. The same problems have plagued the computer software industry ever since its inception and we don't hear them complaining of their imminent collapse at the hands of the pirating hordes. It is incredible that ARIA is suddenly so worried. Law is only effective if it is (1) known and (2) enforced. Music piracy, bar one current case, has never given rise to criminal prosecutions in Australia. As a result, piracy is widespread as there are no repercussions. Even if we also assume that people are genuinely unaware that it is illegal (come on, everyone knows copying music is wrong, but it seems less wrong than theft of physical goods), enforcement is a good way of "publicising" the law, as ignorance of the law is no excuse for violating it. The fact is, digital piracy is easy, free, does not visibly deprive people of anything physical, and proceeds unhindered. Music CDs are the opposite. When CDs are stolen, it is more the theft of the actual physical good, rather than the intellectual property contained on the CD, that is thought of as the crime by the layperson – even though the intellectual property contained on the CD is responsible for the majority of the labelled price. People have been saying this for years: The music industry needs to address the piracy issue differently. They try to publicise that piracy is illegal, but people don't listen because no one gets busted for piracy. They then try to publicise piracy's illegality by enforcing the law. The problem with this is that the customer base for music piracy is made up of a gigantic number of small consumers (many under 18). Picking on individual users is likely to cause resentment among the music community, and perhaps may increase the levels of piracy as a knee-jerk reaction. You're only going to be prosecuted if you get caught, and for 99% of us, getting caught by ARIA is unlikely. Other models, such as Apple's iTunes service, where music can be purchased digitally online for micropayments, while not removing the prevalence of piracy, will certainly mitigate it. Piracy cannot be eradicated, the recording industry should accept that. There are always people who will steal if they can get away with it (and I know of no one without at least one illegal MP3 on their computer). Instead, they should be turning their attention to alternative ways to bring people back to paying for music, and that means addressing why people currently find buying their music unattractive. I have no problem with the idea of music piracy being illegal. Intellectual property should be protected. I only take issue with how the problem is being addressed, though I don't deny that there is no easy or completely satisfactory solution to this. 3:19pm (GMT +10.00) tomorrow from Mac Bank • Music • Tweet This • Comments (3) • The three students must have been trafficking a huge amount of MP3s to have been arrested over it… I don't know anyone who doesn't have an illegal MP3 (or hundred) on their computer. Ad Music, Breaks and Beats Ever wondered what songs or breaks a commercial was using? Here are two UK-based databases: AdvertSongs and Commercial Breaks and Beats. For example, that classic Peugeot ad with the Indian sculptor (full clip is here). This summer the famous Enrique Iglesias had a concert in romania. It was all playback. But some of the sound guys recorded his real voice from microphone output: http://www.247365.com.au/extras/enrique.html. I don't know if this is legit, but it sounds horrendous nonetheless. Thanks Pete! 2:19pm (GMT +10.00) tomorrow • Music • Tweet This • Add a comment • Here's a whole repository of sheet music for Nobuo Uematsu's Final Fantasy compositions, for all types of instruments. Jaxter Music Awards A friend is running a national music composition competition. It's called the Jaxter Artist Awards. Entry fee is $25 for any original composition/song. You have to be under 35, but I don't think that's a problem given the demographics of this site's readership :). Spread the word to any of your musically talented friends. KaZaA still hanging on, despite a court order to shut down. This is an interesting article on the potential follies of record companies releasing CDs that are unplayable through computer CD drives. 3:13pm (GMT +11.00) tomorrow from Work, Burwood • Music • Tweet This • Add a comment • This site is offering 100 free mp3 downloads. You have to provide credit card details, but you can cancel after you grab your music. (It's got Trek on the page, but I think they have more to download besides Trek music.) RIAA vs KaZaA/Morpheus/Grokster Napster's Dead (and they want to charge US$5 a month for it? Do those guys have a brain?), Morpheus may be soon to follow after a lawsuit was filed against it by the RIAA yesterday. Wired article. Napster Alternative Ok we all know Napster has crap all on it now. I haven't had time to try the 100 different alternatives floating around out there, but Morpheus does the job quite nicely. It's got the usual file resumption and segmented download features. More importantly, it reaches around a quarter million users trading 100 terabytes of files during peak time. Pretty reliable (for a dialup connection) and it finds most of the stuff I look for. Seems to be growing too. (Download) 7:00pm (GMT +10.00) • Music • Tweet This • Add a comment • My friend Phil (of Tatterdemalion) has had another venture into music kicking off with four solid funky mixes of rock/techno. So, have a listen to Rebirth. Those tracks so remind me of the .mods they used for the old Star Control games. The Hangover Cure Can't remember the last time I went out and bought a music CD, but The Hangover Cure is a nice mix of songs. A few songs are a bit thumpy, but overall it's not a bad compilation. a-Studyin' It's nothing but me, a book full of obfuscated text lawyers call law, and the soothing strains of some Café Del Mar CDs to help me maintain my sanity. Ambient music at this hour is terrific. I've just had the bludgiest Saturday afternoon. I decided to take the computer downstairs and hook it up to the home theatre amp downstairs. Also gave me the chance to try connecting the never-before-used SPDIF digital out of the SBLive to the coax in of the amp. Then I just laid back on the couch and listened to MP3s for the rest of the arvo. Relaxing :) If you have the chance, try plugging your sound card into a hi-fi system (if you don't have a digital out/in, you'll need a 3.5mm stereo to dual RCA cable)… the difference between them and the comparatively pissy little computer speakers you're probably using is huge (computers don't normally have a 15″ sub). 11:00pm (GMT +10.00) • Music • Tweet This • Add a comment • Great MP3 site (esp if you're a regular Triple J listener, which I'm not) but there's lots of good music there. Napster Buycott Seems to have flopped. (Via Tunney's blog). Incidentally I got an e-mail from him, which was unexpected and gratifying :). Unfortunately, I'm not a Triple J listener, so I've never actually heard him on radio. Napster… Good! A friend and I ordered Napster shirts from Offspring. We'll wear them if we have to do a presentation of our research paper (which will be on MP3s) for IT Law later in the semester :). The radio is dead. My uncle is now supplying mp3 music in his surgery for his patients to listen to. Ok, so the radio isn't really dead, but I did find the fact that he switched over to playing stuff from his mp3 collection amusing. This mp3 Shaf sent me is incredible. It's of some guy singing in Hindi. But what makes it incredible, is he sings for about 2.5 minutes straight on one breath (ie: he never refills his lungs for the entire duration of his singing). It's no coincidence the song is called Breathless. Amazing. I swear, it makes you breathless just listening to it. From CNN Swap MP3s, go to jail? Software piracy is a crime too, but we don't see that ending anytime soon, do we? Wrapster Apparently a Napster add-on that allows transfer of files other than MP3s. Does anyone know where to obtain it? Essential Download I've said before that Napster runs on several separate servers, right? Napigator allows you to poll Napster servers (ping, number of users online etc.) and connect to any of them. Very nice. There's now a Beta 5a version out. Napster Tip There isn't just one Napster server. There are several which are at present unlinked to each other. The master server transparently forwards you to the "optimal one". So, if you can't find a song on the server you're currently on, disconnect and reconnect and most likely the master server will assign you to a different one, with different people. Beta 4 just came out. Looks nicer. Grab now and perpetuate copyright infringement on the net :). MP3 Organiser Looking for a powerful program to catalog your MP3 collection? Try Shuffleplay. It has a feature called a "recursive search" that will find all your mp3s on your computer, on all harddrives. It also will do a batch renaming of files and ID3 tags. Very nice. And there's always this place, if you want to crack it. Schmick MP3s Booya! has been pimping some schmick MP3s lately. MP3 sites Courtesy of Lonestar, which is further courtesy of Bence. Hear Ye! has no compunctions about linking mp3 sites ever since the swede teenager was acquitted :). Link here. Plugged on Geeklife and Shazbot already, Napster is too good to be true. But it's true, and it deserves another plug. Find bloody well any mp3 in 5 minutes. Haha I was taking requests for songs over icq with this and making everyone wonder how I could find songs so quickly :) Useful Spam? Strangely enough, this link is brought to you by spam (weird spam – it had a CC list). DJ008 is an MP3 site which offers DJ mixes. Some good stuff there. Got bandwidth to burn while you sleep? :) Couple of "top 40" type mp3 sites – here (mp3 hitzone), here (mp3 direct download) and here (music lover). Hey. Mr Tambourine. Man. Despite William Shatner's wife dying, I'll make this post. Apparently back in the 60s Shatner released an album, but since he couldn't actually sing, he spoke the words in a dramatic sounding voice. Listen especially to Lucy in the Sky with Diamonds and Mr Tambourine Man. Very much a case of don't skip your day job. And there's also a link to a related album on CDNow. Spock, also has an album. Thanks to Phil. Yo yo yo yo Yoda To the tune of Lola. Hear this (Yoda, not Lola) in MP3 – 3.2MB. Very catchy :) I met him in a swamp down in Dagobah where it bubbles all the time like a giant carbonated soda S-O-D-A soda I saw the little runt sitting there on a log, I asked him his name and in a raspy voice he said Yoda Y-O-D-A yoda yo-yo-yo yo yoda Well I've been around but I ain't never seen a guy who looks like a muppet but he's wrinkled and green oh my yoda Well I'm not dumb but I can't understand how he can lift me in the air just by raising his hand oh my yoda yo yo yo yo yoda yo yo yo yoda Well I left home just a week before and I've never ever been a jedi before but Obi-Wan he set me straight of course, he said yoda yoda and I'll show you the force Well I'm not the kind that would argue with Ben so it looks like I'm gonna start all over again with my yoda, yo yo yo yo yoda so I used the force, I picked up a box I lifted some rocks while I stood on my head Well I won't foget what Yoda said He said Luke stay away from the darker side and if you start to go astray let the force be your guide oh my yoda yo yo yo yoda I know Darth Vader's really got you annoyed but remember if you kill him then you'll be unemployed oh my yoda, yo yo yo yo yoda Well I heard my friends really got in a mess, so I'm gonna have to leave Yoda I guess But I know that I'll be coming back someday I'll be playin' this part 'till I'm old and grey The long term contract I had to sign said I'd be making these movies 'till the end of time (repeat 'till end of song) CDNow CDs Hey… my Star Wars CDs from CDNow arrived… the double CD sets for each of the trilogy movies costed about $18 US, whereas they cost $50 in Australian stores. CDs are too damn expensive here. Lyrics.ch Hey! www.lyrics.ch is back up! Sort of… no lyrics… just album listings. The Phantom Menace Soundtrack in MP3s! Go and grab them before they get yanked off the net! Sunscreen Song forgo Daily posted a copy of The Sunscreen Song on his site (MP3, 16kBps degraded quality, however). So now you can get both The Sunscreen Song (Quindon Tarver version) and Not The Sunscreen Song (John Safran version). Although if you're not Australian, you probably won't get a few of the things said in Not The Sunscreen Song ("Forget Adelaide… it's a hole."). I can't remember if the Safran version is zipped, or merely renamed. So if you can't seem to unzip it, just rename it to have an mp3 extension. UPDATE: I found a full quality MP3 of The Sunscreen Song (aka Everybody's Free (to Wear Sunscreen)). 6 Megs or so, but it's definitely worth it :). Not the Sunscreen Song MP3 I uploaded it and it's available at this address (~5 MB). Enjoy. You'll need to unzip it first (as opposed to merely renaming it). If you don't know what this song is, it's a spoof on Quindon Tarver's "Sunscreen Song" (which is not really a song, just some guy giving advice on living life). This spoof is a cack. Yes I do have this Mp3 (lotsa search engine referrals regarding this). I don't have space to put it up on the web, so just buzz me on ICQ (766185) while I'm online if you want a copy. Or, even better, does someone have any space where I can store a 4 Meg MP3? I know you're looking for them :) Here's a listing of the US Top 10 + download links. American Top 10 MP3. Remember Milli Vanilli? They're still infamous :). Click Here for a small diversion. Plagarised from KillKrazy Directly from Watch the World Die (other great stuff there :), is the answer to the question I asked on 18/12. ask killkrazy Inferno lobbed this question on his website…what's the difference between the music genres rock, alternative rock, and alternative? Instead of emailing him what I thought, I'll answer it here instead. First off, alternative rock and alternative are one and the same thing, so the question really is, "What's the difference between rock and alternative?" Nowadays, and this is gonna sound repetitive, there is no difference. Alternative died when Nirvana hit it big (and was buried when Nine Inch Nails also hit the charts) and record companies realized that the buying public was sick and damn tired of Madonna, Michael Jackson, Def Leppard, and Bon Jovi (and all their clones). So, what the hell was alternative? Well, the genre can only be defined by the bands that were considered alternative. Janes Addiction and the Pixies spring to mind. So does The Smiths, Red Hot Chili Peppers and Skinny Puppy (before their music was classified as Industrial – this may be my own personal interpretation). Love and Rockets (and the previous incarnation of the band Bauhaus – although, as is the case of the Smiths and The Cure, these bands are retroactively called Goth Bands). Basically, alternative was advanced garage bands that were too skilled to be ignored and two weird to gain "mainstream" attention – thus, they were "alternative" to mainstream tastes (as defined by record companies). That's the best I can do for an official definition of the term. But, like I said, alternative is dead. The music scene is one big melting pot of Marilyn Manson, The Prodigy, and Puff Daddy and his extended family. Ten years ago, these bands and others like them would be basically unknown with a hardcore following. Times have changed, thank all that's holy, and now more exposure is given to bands and artists that don't just sing shitty little love songs. Nowadays, the closest anyone comes to being alternative is, maybe, Ani DiFranco or Bif Naked. Maybe Rammstein and Atari Teenage Riot can be thrown in there, too. It's a hard call, and not one I'd like to make to be perfectly honest. Regardless…it's all rock 'n' roll, which is even easier to define…it's whatever music your parents hate. Thanks! There's your answer Yappy. So… it appears all the genres have blended somewhat. Can someone point out the differences between the genres – rock, alternate rock, and alternate? Here's a song that's being played to death on MIX 106.5. I heard From this Moment On (Shania Twain) played 4 times in a 24-hour period, and 3 times in another 24-hour period within the last fortnight. I wasn't even listening 24-hours – it just happened that every time we were in the car, that song was being played. As a sidenote, I *think* I heard somewhere that she was going to sing this at the Nobel Peace Prize… huh? Help! I swear I'm hearing this damn song everywhere – radio, shops, malls – and at least once a day. Stop it! Old news, but it has to be said… One down, "only" four to go… There's something about Aqua's music that makes it fun to listen to. I know that it sounds stupid or annoying or whatever etc. etc., but I find their music enjoyable. As the band says about their own music: "it's so … it's so … corny". So it is intentional. Secondly, they're Danish, and they have strong foreign accents, but when they sing, that accent disappears. It's the same with any other foreign based bands/singers (Celine Dion, The Corrs etc.) … they all seem to revert to an American accent when singing. How do they do that? Hosers. All o' them. And their music isn't too much better either. This letter to the SMH (2/3/98) says it all : Lords of the Skies If I, as an average citizen, became drunk and annoyed and harassed others on an aeroplane I would be restrained and then placed into the hands of police with charges ranging up to and relating to "Safety of Aircraft". But if I was a sportsman or a pop group… C. J. Macpherson, Tamworth. Haha, Tandberg's drawn a cartoon above the letter with one of the Oasis guys, guitar in hand, yelling at a couple of extremely irate passengers : "IT'S COMMON COURTESY TO REQUEST AN F'N ENCORE!". Visit www.dimensionmusic.com for mp3 news – the site for MP3 related material (though I do have a sentimental attachment to the Aussie-run Outer Limits, which is unfortunately still offline). I'll do a write up on what MP3s are later. See Dimension Music anyway, though. It's one of the sites I visit on my "daily site runs" :). You are viewing posts by category.

We purchased our infrared detector locally from ACCESS Elevator, conveniently located in Emeryville, California. Their friendly staff had the Tri-Tronics EDGE in stock and readily available for early morning pick up. The customer had been having intermittent problems with the elevator door reopening when they shouldn't. The EDGE was assembled and installed easily and operated reliably. The management makes every effort to stock parts that are likely to be needed on short notice. The Tri-Tronics EDGE is just one example. Keep up the good work! After seeing a demo of the Tri-Tronics InvisiGuard Razor from our distributor ACCESS Elevator Emeryville, CA., we decided to use it at one of our customer sites. We found the film line design fast and easy to install. The connections to the controller and testing of the door's operation went very smoothly. ACCESS Elevator's staff go the extra mile to help find the parts you need. The management makes every effort to stock parts that are likely to be needed on short notice. Recently, I purchased a the new (Light curtain model) to do an emergency installation from damage caused by the Fire department rescue. ACCESS Elevator Supply had the product in stock and was able to offer a new curtain that was easy to install. I had the unit installed in 2 hours and was thoroughly impressed with how easy it went. The connection threading together is a huge plus to prevent the plastic cords from popping loose. I would definitely recommend this product to all elevator companies. Thank you Amber and ACCESS employees for all your support for our elevator needs. was very easy and we are pleased with the purchase. Compact, open-frame construction delivers a light weight, high performance, submersible solution. available in grey matte and yellow finish. Come by or call us for a quote today.

In summary, our findings indicate that bFGF stimulates CPT1 expression, FA oxidation and lactate production with the participation of PPARβ/δ activation. On the other hand, this investigation shows that FSH concomitantly regulates the expression of genes involved in FA metabolism and in mitochondrial biogenesis in Sertoli Capecitabine independently of PPARβ/δ activation. Metabolic processes such as FA oxidation, mitochondrial biogenesis and lactate production in Sertoli cells are essential for the energetic metabolism of the seminiferous tubule. The fact that these processes are regulated by hormones in a different way reflects the multifarious regulation of molecular mechanisms involved in Sertoli cell function. Funding This work was supported by Grants from the Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET) (PIP 2011/187) and from the Agencia Nacional de Promoción Científica y Tecnológica (PICT 2011/677) and (PICT 2012/666). Introduction Drugs targeting tumor blood vessels are commonly used in cancer patients and they generally produce limited therapeutic benefits for survival improvement (Cao et al., 2011). One of the main hitches of low therapeutic efficacy is that cancer patients often develop resistance in response to antiangiogenic drug (AAD) treatment (Bergers and Hanahan, 2008, Cao and Langer, 2010, Cao et al., 2009, Casanovas et al., 2005, Chung et al., 2013, Crawford et al., 2009). Patients with cancers grown in organs adjacent to adipose tissues, including breast cancer, prostate cancer, pancreatic cancer, and hepatocellular carcinoma (HCC), show particularly low benefits from antiangiogenic therapy. These cancers located adjacent to adipose tissues often show intrinsic or acquired resistance to antiangiogenic therapy. For example, most patients with pancreatic ductal adenocarcinoma (PDAC) show intrinsic resistance and colorectal cancer (CRC) patients exhibit evasive resistance to bevacizumab (Van Cutsem et al., 2009). A puzzling observation in the field of antiangiogenic cancer therapy has been the inconsistency of drug effects in preclinical animal models and in cancer patients (Cao et al., 2011). While most AADs produce overwhelming anti-tumor effects in mouse models, the same drug often lacks anti-cancer effect in human patients. Among numerous possible reasons, the location of tumor implantation in animal models is often different from clinical situations. For example, subcutaneous implantation is a common location for studying animal tumors for the sake of convenience in monitoring tumor growth. However, human tumors rarely originate from a subcutaneous location. Tumor tissues often experience hypoxia owing to accelerated growth rates of malignant cells, accumulation of metabolic products, disorganization of tumor blood vessels, and high interstitial fluid pressures (Makino et al., 2001). In response to AAD treatment, tumor vascular density often decreases to an extremely low level, creating an elevated hypoxic environment (Rapisarda and Melillo, 2012). It is known that tumor hypoxia can exacerbate expression levels of growth factors and cytokines, which circumvent the drug targets and create possible resistance (Casanovas et al., 2005). Hypoxia may also change the composition of various cell types within the tumor microenvironment (TME), leading to alteration of cancer invasiveness and drug responses (Cao et al., 2009). Unlike most healthy cells, cancer cells exhibit distinctive features of uncontrolled cell proliferation (Hanahan and Weinberg, 2011). To cope with the unlimited growth, expansion, and dissemination, cancer cells must efficiently produce energy, even in poorly oxygenated and nutrient-scarce microenvironments (Beloribi-Djefaflia et al., 2016). Cancer cells show exacerbated glucose uptake and glycolysis-dependent metabolism (i.e., the Warburg effect; Warburg, 1956). In addition, malignant cells also rely on glutamine consumption to obtain carbon, amino-nitrogen for producing nucleotides, amino acids, and lipid biosynthesis. Recent studies show that highly proliferative cancer cells have lipogenic activity by uptake of exogenous lipids and activating endogenous lipid biosynthesis (Beloribi-Djefaflia et al., 2016). Utilization of exogenous free fatty acids (FFAs) for energy production through the fatty acid oxidation (FAO) metabolic pathway is prominent in non-glycolytic cancers such as prostate cancer and B cell lymphoma (Caro et al., 2012, Liu et al., 2010). Several lipogenic enzymes, including acetyl coenzyme A carboxylase and fatty acid synthase (FASN), are often increased in invasive tumors and their expression levels correlate with poor prognosis (Kuhajda, 2006). The FAO-limiting enzyme, CPT1 (A and C types), is often overexpressed in many human tumors (Reilly and Mak, 2012). It is known that adipose tissue and FFA significantly contribute to cancer cell survival, proliferation, and migration (Lazar et al., 2016, Nieman et al., 2011). Previously published work also showed that anti-VEGF treatment and tissue hypoxia increase lipid transport and storage through an HIF-1α-dependent mechanism in cancer cells (Bensaad et al., 2014). Nevertheless two problems exist in BGCFC in practice The fir

Follow our Facebook page to stay updated with all of our specials and events. Create awesome times over good food and with great company. COPPER FIRE in Belleville, IL offers mouthwatering dishes that will surely satisfy your palate. We also provide various catering options for special occasions. Most of our menu items include meals from American cuisine and cover everything, from a casual lunch to an impressive dinner—and a few surprises in between. After having your fill of exquisite dishes, why not indulge in one of our finest wines, cocktails or beers? Our mixologists will create an excellent cocktail, made with choice ingredients, to serve as a perfect companion to your meal. Treat yourself to our delicious dishes that are guaranteed to have you licking your plate clean. Whether you're a professional who wants to take your team members out for dinner or looking for a place to catch up with friends, our restaurant should be on top of your list. We love our military members at Copper Fire! If you are an active member of a military branch, stop in for a 10% discount. Creating the ultimate dining experience is not only about food and drinks. The ambiance of the place also matters. At COPPER FIRE, you'll get to see live acoustic entertainment shows that will surely make your visit to our restaurant all the more enjoyable.

Does Jerusalem's Fall In 70 A.D. Matter To The U.S. Today? When Jesus Christ looked out over Jerusalem, He wept (Luke 19:41). Why this outburst of emotion? It was not merely the realization that the city would soon be destroyed in a devastating war (vs. 43-44). It was concern over what the populace of that glittering metropolis was doing to itself to bring that devastation about. Precisely, the same human nature, the same vicious attitude of mind, which was (and is) extant all over the world was then being unleashed in Jerusalem. And the people there could no more resist it than could any other people in any other city at any other time. Outwardly the Jerusalem known by Jesus Christ had reached the pinnacle of grandeur, wealth and architectural achievement. But under the surface were vices only too familiar to the urban America of 2007. "Stripped whole cities, ruined complete communities, and virtually announced to the entire country that everyone might be a bandit if he chose, so long as (Florus) himself received a rake-off" (The Jewish War, translated by G.A. Williamson, II. 14.). In Jerusalem the people courageously sought to break the bonds of Roman oppression.And they quite understandably became desperate. Young hotheads grew restless. Rioting became a favorite pastime. In fact, unscrupulous government and civic leaders found it convenient to cover up their own crimes by inciting the mobs of the city to riot. The favorite scene for mob confrontations and riots was Jerusalem's splendid Temple of God, where hundreds of thousands of worshippers congregated on religious festivals.It was, in fact, on these festivals -- Days of Unleavened Bread, Pentecost, Feast of Tabernacles--that civil strife reached its zenith (Wars, II. 1.3; II. 3.1). Violence finally became so common that armed guards were posted on permanent duty in the Temple during feasts "to forestall any rioting by the vast crowds" (ibid, II. 1.2.1). Even so, political, religious and professional agitators, gang leaders and revolutionaries still did their part.Oftentimes, the frustrated passions of an oppressed people became vented in a tragically self-destructive manner. To modern-day Americans these mob scenes would have a familiar ring. "But in the afternoon a number of men with revolutionary ideas collected, and began lamentations (complaints) of their own, piercing wails, weeping in chorus, and beating of breasts, that resounded throughout the whole city" (ibid., II . 1.2). Just to test the government's sincerity, the mob began to make large demands: tax reduction, abolition of sales tax, and release of prisoners.In Short, the Jerusalem of the first century A.D. enjoyed all the fruits of an intricate multifaceted urban civilization with which we are becoming too painfully familiar in our own day. There was violence, crime, and racial conflicts among Samaritans, Jews and Greeks, arson, looting of stores and burning of credit records, raiding of armories, gang warfare and political assassination. Unscrupulous rulers blamed the riotous mobs in order to divert attention from their own crimes. The revolutionary party in Jerusalem cast off all restraint. Every scoundrel surrounded by his own gang, stood out from his followers like a bandit chief or dictator and used his henchmen to rob respectable citizens (ibid, II. 14.1). Of all the cities under Roman rule our own reached the highest summit of prosperity, and in turn fell into the lowest depths of misery, and for our misfortunes we have only ourselves to blame (ibid., pref., 4). What occurred in Jerusalem more than 1900 years ago has a particular significance for today. Not for the Jerusalem of today, but rather for the urban areas of the United States and British Commonwealth. In a direct prophecy to these peoples, the prophet Ezekiel wrote: "The land if full of bloody crimes and the city is full of violence." (Ezk. 7:23).Especially American cities. But how many of us weep over America the way Jesus Christ wept over Jerusalem? Many of the prophecies of the Bible are dual.As Jerusalem fell in 70 A.D., so will America fall. Human nature never changes.We always follow the course of self destruction.The question is NOT IF we fall, but WHEN.

Sake Dean Mahomed: The Man Who Brought Shampooing to Great Britain by Akarsh Shekhar October 1, 2020 October 21, 2020 Shake Dean Mahomed (actual Urdu name: Sheikh Din Muhammad) was a famous Indian shampoo surgeon and restaurateur who holds the honour of being one of the first non-European immigrants who were embraced by the Western World. As it was common at that time, his actual Urdu name's spelling was modified to make it easier for Britishers to pronounce it so Sheikh Din Muhammad became Sake Dean Mahomed (alongwith numerous other iterations). This legendary Indian immigrant holds the honour of introducing Indian cuisine and shampoo baths to Europeans. He also holds the distinction of being the first Indian to publish a book in English. Let's find out more about this amazing individual. Sake Dean Mahomed: All You Need to Know When was Sake Dean Mahomed born? Where did Sake Dean Mahomed grow up? When did Sake Dean Mahomed leave India? Who did Sake Dean Mahomed marry? How many children did Sake Dean Mahomed have? What is the name of Sake Dean Mahomed's book? Who opened England's first Indian restaurant? Who introduced shampooing to England? Did Sake Dean Mahomed write books on shampooing? When did Sake Dean Mahomed die? What is Sake Dean Mahomed's legacy? Sake Dean Mahomed was born on January 15th, 1749 in the ancient city of Patna. The current capital of the Indian state of Bihar was a part of British India's Bengal Presidency at that time. Sake Dean Mahomed's parents were Bengali muslims who were allegedly related to Bengal's Nawabs. Sake Dean Mahomed also claimed that he had ancestors who worked in administrative service under the Mughal Emperors. He belonged to the Maniharzada caste, and had studied alchemy and understood the methods used to produce various alkalis, soaps and shampoo. Sake Dean Mahomed grew up in the city of Patna. Unfortunately, his father passed away while serving for the East India Company's Bengal army when Mahomed was just 11 years old. Captain Godfrey Evan Baker took Deam Mahomed under his wings after his father died. Dean Mahomed fought with the East India's Company army as a trainee surgeon during the company's conquest of the Marathas. Mahomed remained with Captain Baker until 1782, when the Captain resigned. That same year, Mahomed also resigned from the Army, choosing to accompany Baker, 'his best friend', to Ireland. In 1784, Sake Dean Mahomed left India with the Baker family and emigrated to Cork, Ireland. There he studied to improve his English language skills at a local school. While improving his English skills, Sake Dean Mahomed fell in love with Jane Daly, a "pretty Irish girl of respectable parentage". As it could be expected at that time, Jane Daly's family was strictly against the union and the couple was forced to elope and get married in 1786. Mahomed and Daly were married in the Diocese of Cork & Ross in Cork, Ireland. In order to marry Jane Daly, Sake Dean Mahomed had to leave his Islamic faith and convert to Anglicanism. He had to specifically convert to Anglicanism since Protestants were legally prevented from marrying non-Protestants. They moved to 7 Little Ryder Street in London, England, at the turn of the 19th century." According to leading scholars, and as indicated by parish records in London, Mahomed conducted a bigamous marriage in Marylebone in 1806 to Jane Jeffreys (1780-1850); the banns were read on 24 August for Jane and "William Mahomet." He had a daughter, Amelia (b. 1808) with her and is listed as the father "William Dean Mahomet" in the parish register. Amelia was baptised on 11 June 1809 at St Marylebone, Westminster, in London. By his legal wife, Sake Dean Mahomed had seven children: Rosanna, Henry, Horatio, Frederick, Arthur, and Dean Mahomed (baptised in the Roman Catholic church of St. Finbarr's, Cork, in 1791) His son, Frederick, was a proprietor of Turkish baths at Brighton and also ran a boxing and fencing academy near Brighton. His most famous grandson, Frederick Henry Horatio Akbar Mahomed (c. 1849–1884), became an internationally known physician and worked at Guy's Hospital in London. He made important contributions to the study of high blood pressure. Another of Sake Dean Mahomed's grandsons, Rev. James Kerriman Mahomed, was appointed as the vicar of Hove, Sussex, in the late 19th century. Sake Dean Mahomed's book The Travels of Dean Mahomet On 15 January 1794, Mahomed published his travel book, entitled The Travels of Dean Mahomet. The book is in epistolary form as was common for travel books and many novels in that era and consists of 38 letters. The book begins with a brief introduction where he contrasts Ireland and India, writing that "the face of every thing about me [is] so contrasted to those striking scenes in India" and proceeds to give a sketch of his early years. He then describes his travels over the period 1770 to 1775 as a camp follower to the Bengal army as it moved around North East India. A series of military conflicts are described along with descriptions of some major cities, including Kolkata (Calcutta) and Varanasi (Benares). This is accompanied by first hand accounts of Indian culture, trade, military conflicts, food, wildlife, etc. The book concludes with a description of Mahomed's voyage to Britain where he arrived at Dartmouth in September 1784. While Mahomed gives an insightful and sympathetic account of India and Indian customs, as Mona Narain points out this is done from an essentially European cultural perspective – he consistently uses the pronoun "we" to describe himself and Europeans, and does not in his writings seek to challenge poor governmental management within the East India Company. The historian Michael Fisher, who published a biographical essay to accompany an edition of the book, suggested that some passages in the book were closely paraphrased from other travel narratives written in the late 18th century. Sake Dean Mahomed opened London's first ever Indian Restaurant, the Hindoostane Coffee House in George Street, near Portman Square, Central London. The restaurant's highlights were hookah "with real chilm tobacco, and authentic (or as authentic as they could be) Indian dishes. The curries made in Deam Mahomed's restaurant were considered unparalleled and unequalled by any curry ever made in England. The landmark restaurant had to close because of financial troubles but it heralded the start of a new era where "curry houses" have become as British as the pub these days. Prior to his restaurant business in London, Dean Mahomed worked in London for nabob, Basil Cochrane, who had installed a steam bath for public use in his house in Portman Square and promoted its medical benefits. Dean Mahomed is widely credited as the person who brought the tradition of Indian massage, or "champooing" to Great Britain. The term soon transformed into "shampooing". In 1814, Mahomed and his wife moved back to Brighton and opened the first commercial "shampooing" vapour masseur bath in England, on the site now occupied by the Queen's Hotel. A local paper described the treatment as "The Indian Medicated Vapour Bath (a type of Turkish bath), a cure to many diseases and giving full relief when everything fails; particularly Rheumatic and paralytic, gout, stiff joints, old sprains, lame legs, aches and pains in the joints".This business was an immediate success and Dean Mahomed became known as "Dr. Brighton". Hospitals also started sending patients to him and he even worked as the shampooing surgeon for the British Royalty. The literary critic Muneeza Shamsie notes that Mahomed wrote two books connected to his burgeoning trade. The first was Cases Cured by Sake Deen Mahomed, Shampooing Surgeon, and Inventor of the Indian Medicated Vapour and Sea-Water Bath (1820), while the second, Shampooing; or, benefits resulting from the use of the Indian medicated vapour bath, went through three editions (1822, 1826, 1838) and was dedicated to King George IV. In this work, Mahomed speaks of the initial resistance to the idea of shampooing among the English he encountered in his new country: "It is not in the power of any individual to give unqualified satisfaction, or to attempt to establish a new opinion without the risk of incurring the ridicule, as well as censure, of some portion of mankind. So it was with me: in the face of indisputable evidence, I had to struggle with doubts and objections raised and circulated against my Bath, which, but for the repeated and numerous cures affected by it, would long since have shared the common fate of most innovations in science." Sake Dean Mahomed's headstone in Brighton Sake Dean Mahomed passed away on February 24th 1851 at 32 Grand Parade, Brighton. He had turned 92 a little over a month before his death. He was buried in a grave at St Nicholas Church, Brighton, in which his son Frederick was later interred. Frederick taught fencing, gymnastics and other activities in Brighton at a gymnasium he built on the town's Church Street. By the Victorian period, Sake Dean Mahomed had begun to lose prominence as a public figure and until the scholarly interventions of the last fifty years was largely forgotten by history. The modern renewal of interest in his writings developed after poet and scholar Alamgir Hashmi drew attention to this author in the 1970s and 1980s. A book on Sheikh Dean Mahomed was written by Michael H. Fisher and it was titled "The First Indian Author in English: Dean Mahomed in India, Ireland, and England". The book was published by the Oxford University Press (OUP). Additionally, Rozina Visram's Ayahs, Lascars and Princes: The Story of Indians in Britain 1700–1947 (1998) was highly influential in drawing public attention to Mahomed's life and work. Several commemorations of and tributes to Mahomed's legacy have taken place in the 21st century. On 29 September 2005 the City of Westminster unveiled a Green Plaque commemorating the opening of the Hindoostane Coffee House. The plaque is at 102 George Street, close to the original site of the coffee house at 34 George Street. On 15 January 2019. Sake Dean Mahomed's plaque in Westminster A man of many talents, Sake Dean Mahomed was an entrepreneur who made a name for himself by building cultural connections between India and England. On this day in 1794, he became the first Indian author to publish a book in English and later, to open an Indian restaurant in England—ushering in what would become one of Great Britain's most popular cuisines. Mahomed went on to find success as the "The Shampooing Surgeon of Brighton," opening a spa in the British seaside town that attracted the rich and royal. In celebration of Sake Dean Mahomed's life, Google released a doodle on January 15th, 2019. This is what the Google Doodle Blog said: "In 1810, after moving to London, Mahomed opened the Hindostanee Coffee House, Britain's first Indian restaurant. The Epicure's Almanack—an early London restaurant guide—hailed it as a place for nobility to enjoy hookah and Indian dishes of the highest perfection. Nonetheless, Mahomed was forced to close his luxurious restaurant in 1812 and sought to reinvent himself. Moving his family to the beachside town of Brighton, he opened a spa named Mahomed's Baths offering luxurious herbal steam baths. His specialty was a combination of a steam bath and an Indian therapeutic massage—a treatment he named "shampooing" inspired by the Hindi word champissage meaning "a head massage." He also published a book about the therapeutic benefits of the treatment with testimonials from his patients. In 1822, King George IV appointed Mahomed as his personal 'shampooing surgeon', which greatly improved his business. A portrait of Mahomed hangs in the Brighton Museum, commemorating this man who helped merge the cultures of his two homelands. Happy Birthday, Sake Dean Mahomed!" Sheik Din Muhammad (Bengali: শেখ দীন মোহাম্মদ; 1749–1851) was an Indian explorer, specialist and business visionary who was one of the most striking early non-European outsiders toward the Western World. Due to his unfamiliar inception, his name is frequently spelled different routes in English documentation. He presented Indian food and cleanser showers to Europe, where he offered helpful massage. He was likewise the primary Indian to distribute a book in English. "insofar as the Sepoy's keep up their arrangements, which they call 'lines,' they resemble a steady well of lava regurgitating ordnance and rifle discharge like persistent hail on the foe, and they are only from time to time vanquished." Mahomet 1794 Conceived in c. May 1749 in the city of Patna then aspect of the Bengal Presidency in British India. He was from a Bengali Muslim family. He professed to be identified with the Nawabs of Bengal, and that he had progenitors who worked in managerial assistance under the Mughal Emperors. He had a place with the Maniharzada station , and had considered speculative chemistry and perceived the strategies used to create different soluble bases, cleansers and shampoo. Purpose Dean Mahomed experienced childhood in Patna. His dad served in the East India Company's Bengal Army and kicked the bucket in fight when Mahomed was around eleven years old. Following his dad's passing, he was taken under the wing of Captain Godfrey Evan Baker, an Anglo-Irish Protestant official. Mahomed served in the multitude of the East India Company as a learner specialist and served against the Marathas. Mahomed stayed with Captain Baker until 1782, when the Captain surrendered. That very year, Mahomed additionally left the Army, deciding to go with Baker, 'his closest companion', to Ireland. Grown-up life and Family In 1784, Mahomed emigrated to Cork, Ireland, with the Baker family. There he concentrated to improve his English language aptitudes at a neighborhood school, and went gaga for Jane Daly, a "pretty Irish young lady of good parentage". The Daly family was against their relationship, so the couple ran off to another town to get hitched in 1786. Mahomed and Daly were hitched in the Diocese of Cork and Ross in Cork, Ireland. around then it was unlawful for Protestants to wed non-Protestants, so Mahomed changed over to Anglicanism to wed Jane Daly (1761-1844). They moved to 7 Little Ryder Street in London, England, at the turn of the nineteenth century." As per driving researchers, and as demonstrated by ward records in London, Mahomed led a bigamous marriage in Marylebone in 1806 to Jane Jeffreys (1780-1850); the banns were perused on 24 August for Jane and "William Mahomet." He had a girl, Amelia (b. 1808) by her and is recorded as the dad "William Dean Mahomet" in the area register. Amelia was absolved on 11 June 1809 at St Marylebone, Westminster, in London.[16] By his lawful spouse, Sake Dean Mahomed had seven youngsters: Rosanna, Henry, Horatio, Frederick, Arthur,[8] and Dean Mahomed (sanctified through water in the Roman Catholic church of St. Finbarr's, Cork, in 1791). His child, Frederick, was an owner of Turkish showers at Brighton and furthermore ran a boxing and fencing institute close to Brighton. His most well known grandson, Frederick Henry Horatio Akbar Mahomed (c. 1849–1884), turned into a globally known physician and worked at Guy's Hospital in London. He made significant commitments to the investigation of high blood pressure. Another of Sake Dean Mahomed's grandsons, Rev. James Kerriman Mahomed, was named as the vicar of Hove, Sussex, in the late nineteenth century. The Travels of Dean Mahomet On 15 January 1794, Mahomed distributed his travel guide, entitled The Travels of Dean Mahomet. The book is in epistolary structure as was regular for travel guides and numerous books in that period and comprises of 38 letters. The book starts with a concise presentation where he differentiates Ireland and India, composing that "the essence of every little thing about me so differentiated to those striking scenes in India." and continues to give a sketch of his initial years. He at that point portrays his movements over the period 1770 to 1775 as a camp devotee to the Bengal armed force as it moved around North East India. A progression of military clashes are depicted alongside portrayals of some significant urban communities, including Kolkata (Calcutta) and Varanasi (Benares). This is joined by direct records of Indian culture, exchange, military clashes, food, untamed life, etc. The book closes with a portrayal of Mahomed's journey to Britain where he showed up at Dartmouth in September 1784. While Mahomed gives a savvy and thoughtful record of India and Indian traditions, as Mona Narain calls attention to this is done from a basically European social viewpoint – he reliably utilizes the pronoun "we" to portray himself and Europeans, and doesn't in his compositions try to challenge poor legislative administration inside the East India Company. The history specialist Michael Fisher, who distributed an anecdotal article to go with a release of the book, recommended that a few sections in the book were firmly summarized from other travel accounts written in the late eighteenth century. 1794 Frontispiece of Dean Mahomet's Travels Café adventure Plaque recognizing Mahomed's café In 1810, subsequent to moving to London, Sake Dean Mahomed opened the principal Indian eatery in England: the Hindoostane Coffee House in George Street, close to Portman Square, Central London. The café offered, among different things, hookah "with genuine chilm tobacco, and Indian dishes, … permitted by the best epicures to be unmatched to any curries ever constructed in England." This endeavor reached a conclusion because of budgetary difficulties. Acquaintance of shampooing with Europe Prior to opening his café, Mahomed had worked in London for nabob, Basil Cochrane, who had introduced a steam shower for public use in his home in Portman Square and advanced its health advantages. Mahomed may have been answerable for presenting the act of champooi or "shampooing" (or Indian back rub) there. In 1814, Mahomed and his significant other moved back to Brighton and opened the primary business "shampooing" fume masseur shower in England, on the site presently involved by the Queen's Hotel. He portrayed the treatment in a nearby paper as "The Indian Medicated Vapor Bath (sort of Turkish shower), a fix to numerous maladies and giving full alleviation when everything fizzles; especially Rheumatic and incapacitated, gout, firm joints, old injuries, faltering legs, a throbbing painfulness in the joints".[26] This business was a prompt achievement and Dean Mahomed got known as "Dr. Brighton". Emergency clinics alluded patients to him and he was delegated as shampooing specialist to both King George IV and William IV. Mahomed's Baths, Brighton, 1826 The scholarly pundit Muneeza Shamsie noticed that Mahomed composed two books associated with his expanding trade. The originally was Cases Cured by Sake Deen Mahomed, Shampooing Surgeon, and Inventor of the Indian Medicated Vapor and Sea-Water Bath (1820), while the second, Shampooing; or, advantages coming about because of the utilization of the Indian cured fume shower, experienced three releases (1822, 1826, 1838) and was devoted to King George IV. In this work, Mahomed discusses the underlying protection from shampooing among the English he experienced in his new nation: "It isn't in the intensity of any person to give inadequate fulfillment, or to endeavor to build up another sentiment without the danger of causing the derision, just as blame, of some part of humankind. So it was with me: despite undeniable proof, I needed to battle with questions and complaints raised and flowed against my Bath, which, however for the rehashed and various fixes affected by it, would since a long time ago have shared the basic destiny of most advancements in science." Mahomed was covered at St Nicholas' Church, Brighton. Mahomed passed on 24 February 1851 (matured 91–92) at 32 Grand Parade, Brighton. He was covered in a grave at St Nicholas Church, Brighton, in which his child Frederick was later entombed. Frederick showed fencing, acrobatic and different exercises in Brighton at a recreation center he based on the town's Church Street. By the Victorian time frame, Sake Dean Mahomed had started to lose noticeable quality as a well known person and until the academic intercessions of the most recent fifty years was generally overlooked by history. The advanced recharging of enthusiasm for his compositions created after artist and researcher Alamgir Hashmi caused to notice this creator during the 1970s and 1980s. Michael H. Fisher has composed a book on Sheik Dean Mahomet entitled The First Indian Author in English: Dean Mahomed in India, Ireland, and England (Oxford University Press, Delhi, 1996). Moreover, Rozina Visram's Ayahs, Lascars and Princes: The Story of Indians in Britain 1700–1947 (1998) was exceptionally compelling in causing public to notice Mahomed's life and work. A few remembrances of and accolades for Mahomed's heritage have occurred in the 21st century. On 29 September 2005 the City of Westminster divulged a Green Plaque celebrating the kickoff of the Hindoostane Coffee House. The plaque is at 102 George Street, near the first site of the café at 34 George Street. On 15 January 2019, Google perceived Sake Dean Mahomed with a Google Doodle on the principle page. 5 Most Valuable Quotes that Will Motivate You to Study The Best Social Media Hacks for Small Businesses Maria Felix: The Most Beautiful Face in Mexican Cinema Akarsh Shekhar August 4, 2019 March 14, 2020 Best Casinos to Play Slots When Vegas Opens Akarsh Shekhar May 21, 2020 January 11, 2021 How to Find a Group to Join in Call of Duty Warzone Akarsh Shekhar November 27, 2020 November 27, 2020

When Should you Have Your Mattresses Cleaned? Cleaning a mattress (that is used daily) at least once a year is a great way to keep it in the best possible condition. Accidents such as spills, stains, odors, water damage may require immediate attention. We're here to make the process quick, easy and affordable. It's surprising to know that many people aren't aware that a mattress can be professionally cleaned. Mattress fabrics, as with most other fabrics, soil over time absorbing items from the surrounding environment along with a steady buildup of your biological 'left overs' such as dead skin. Since most people spend about 1/3 of their life on a mattress, an annual cleaning is a very practical investment. Your mattress can be completely cleaned and sanitized in less time it takes to wash and dry a load of laundry. extend the usable life of your mattress. A proper mattress cleaning must penetrate as deep as the stain and then be flushed and extracted out of your mattress properly to avoid mold, mildew and build-up. Our Mattress Cleaning process will do the heavy lifting for you and have your mattress totally clean and sanitized. Can a mattress really be cleaned? Yes… any mattress that is used on a regular basis can and should be cleaned to eliminate and prevent buildup of contaminants including dead skin, allergens, stains, odors, etc. For mattresses getting normal use, we recommend cleaning at least once a year. However, if you have pets sleeping with you or if you have allergies or asthma we recommend every 6 months to maintain a significantly lower level of irritants in your mattress. In the event of accidents causing potential stains or odors we recommend a professional mattress cleaning as soon as possible. Are toxic or dangerous chemicals used in your cleaning process? Absolutely not! We use a mineral based non-toxic, allergy and asthma safe, soap-free anti-microbial cleaning solution that is EPA certified and meets all green certification standards. How exactly will you clean my mattress(s)? We utilize a 3-step mattress cleaning process: Step 1 – we thoroughly vacuum every surface of the mattress – top, sides and bottom. Step 2 – we apply a dry-foam anti-microbial cleaner and agitate by hand with natural sponges. Step 3 – we rinse with 210 degree water utilizing a special low-moisture upholstery cleaning system. How long will it take my mattress to dry? Because we use a low-moisture cleaning system, under normal conditions, it shouldn't take more than 2 hours for your mattress to be completely dry and ready to apply linens. Can you remove the stains on my mattress? We pretreat all spots and stains and most will be completely gone or significantly reduced. Probably. There are mites in over 95% of mattresses and many with high enough concentrations to cause allergic reactions in people who never exhibited any previous allergic tendencies. Should I really replace my mattress after 7 years? This is what the mattress industry would like for you to believe. However, if you aren't experiencing sleep discomfort due to mattress structural issues we can save you a lot of money by cleaning and sanitizing your existing mattress. This will freshen your mattress by removing the buildup of dead skin, bacteria and odors and allow extended use of your mattress.

Meghnad Saha: Indian Astrophysicist Mr Singh Meghnad Saha Who Was Meghnad Saha? Meghnad Saha was an Indian astrophysicist who is known for his contributions to the field of astrophysics. He is best known for developing the Saha equation, which is used to determine the physical conditions in stars. Saha made many significant contributions to the field of astrophysics, and his work had a lasting impact on our understanding of the physical processes that occur in stars. In addition to the Saha equation, he also developed a theory of the ionization of gases, which is known as the Saha ionization equation. He also made important contributions to the understanding of the behavior of white dwarfs, which are the final stage of evolution for stars like the Sun. Saha received many awards and honors for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit. Meghnad Saha was born in 1893 in the village of Dacca in East Bengal (now Bangladesh). He was the fourth of six children born to Jagannath Saha and Bhubanmohini Saha. His father was a wealthy landowner and his mother was a housewife. Saha received his early education at the village school in Dacca and later attended the Brahmo Boys School in Calcutta. He excelled in his studies, particularly in mathematics and physics, and received a scholarship to study at the Presidency College in Calcutta. Saha stayed at the Eden Hindu Hostel, which was provided to him by his university. Unfortunately, while he stayed there, he was the victim of caste discrimination because Saha belonged to the shudra caste; the lowest caste. The caste system made his life at university quite difficult. After completing his Bachelor's degree in 1915, Saha joined the University of Calcutta as a research student. He received his Master's degree in 1917 and began teaching at the university as a professor of physics. Saha was a brilliant scientist and was deeply interested in the study of astrophysics. He spent long hours in his laboratory, often working late into the night, and made many significant contributions to the field. In addition to his work as a professor, Saha also served as the director of the Indian Institute of Science in Bangalore and as the chairman of the Council of Scientific and Industrial Research in India. Meghnad Saha on Right Hand Side He is best known for developing the Thermal Ionisation Equation, which is used to determine the physical conditions in stars. The Saha equation is a mathematical expression that describes the ionization of gases in stars. It is based on the principles of statistical mechanics and is used to determine the temperature, density, and ionization state of a star. The equation is an important tool for understanding the physical processes that occur in stars, and it has many applications in fields such as astrophysics, planetary science, and cosmology. Saha received many awards and honours for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit. The Saha Equation The Saha ionization equation was developed in the 1920s and is based on the principles of statistical mechanics. The equation is written as: [Ionized atoms]/[Neutral atoms] = 2(2πmkT/h²)^(3/2) exp(-Ei/kT) The left side of the equation represents the ratio of ionized atoms to neutral atoms in a gas, and the right side represents the probability of ionization. The equation is used to determine the ionization state of a gas, based on its temperature, density, and ionization energy. The equation is an important tool for understanding the physical processes that occur in gases, and it has many applications in fields such as astrophysics, planetary science, and cosmology. It is used to study the behaviour of gases under different conditions and to predict the evolution of their physical properties over time. Saha Equation Saha's Publications Saha published many papers and articles on a wide range of topics, including the structure and evolution of stars, the ionization of gases, and the behaviour of white dwarfs. Some of Saha's notable publications include: "The Ionization of Gases by Heat," which was published in the Proceedings of the Royal Society in 1920. This paper introduced the Saha ionization equation, which is used to determine the ionization state of gases. "The Ionization of Gases by Heat. II," which was published in the Proceedings of the Royal Society in 1922. This paper further developed the Saha ionization equation and applied it to the study of the ionization of gases in stars. "The Intensity of the Spectral Lines of the Hydrogen Spectrum and the Density of the Electron Gas in the Stars," which was published in the Astrophysical Journal in 1926. This paper introduced the Saha equation, which is used to determine the physical conditions in stars. "The Structure and Evolution of Stars," which was published in the Annual Review of Astronomy and Astrophysics in 1949. This paper summarized Saha's work on the structure and evolution of stars and provided an overview of the current state of knowledge in the field. "The Thermionic Emission of Electrons," which was published in the Proceedings of the Royal Society in 1952. This paper presented Saha's theory of the thermionic emission of electrons and its applications to the study of the behavior of white dwarfs. Saha was also an avid reader and enjoyed reading books on a wide range of topics, including science, literature, and history. He was also an accomplished musician and enjoyed playing the sitar in his free time. Saha was highly respected in the scientific community and was known for his integrity and dedication to his work. He received many awards and honors for his scientific contributions, including the Padma Bhushan, the C.V. Raman Medal, and the Order of Merit. Meghnad Saha died on February 16, 1956, at the age of 62. Sources and Further Reading MN Saha: A scientist who cared | The Hindu BusinessLine Meghnad Saha Biography | Facts, Childhood, Family Life & Achievements Meghnad Saha was an eminent astrophysicist best known for his theory of thermal ionization. This biography of Meghnad Saha provides detailed information about his childhood, life, achievements, works and timeline. Meghnad Saha: Physicist and nationalist: Physics Today: Vol 69, No 8 Deeply committed to the cause of Indian independence, Saha occasionally detoured from his physics to conduct a revolutionary mission or pen a populist manifesto. Biography of Meghnad Saha(1893 – 1956 ) | Robolab Technologies Pvt. Ltd. Meghnad Saha was a great Indian scientist. He made a remarkable contribution to the field of Astrophysics. Meghnad N. Saha | Indian astrophysicist | Britannica Meghnad N. Saha, (born Oct. 6, 1893, Seoratali, near Dacca, India—died Feb. 16, 1956, New Delhi), Indian astrophysicist noted for his development in 1920 of the thermal ionization equation. © 2023 Mr Singh

AT&T Moves Further From vMVPD Model With New Price Hikes Monday, October 21, 2019, 12:23 PM ET AT&T is moving further away from the low-cost virtual MVPD ("skinny bundle") model it helped pioneer with DirecTV Now back when it launched in 2016. Per multiple reports on Friday, AT&T will increase the monthly price of its "Plus" tier by $15 (to $65 per month) and its "Max" tier by $10 (to $80 per month) in November. This past summer AT&T rebranded DirecTV Now as AT&T TV Now. DirecTV Now had already imposed a $10 per month price hike back in March and consolidated DirecTV Now's original 3 tiers into the 2 current tiers and included HBO with both of them. If you were to back out the $15 per month that a standalone HBO Now subscription would cost, then the "Plus" and "Max" tiers would be $50 per month and $70 per month, respectively. Those rates are essentially in line for comparable vMVPD services like YouTube TV ($50 per month), Hulu with Live TV ($45 per month), fuboTV ($55 per month) or PlayStation Vue ($55 per month for Core tier). All of these services include the major broadcast TV networks and a lot of other overlapping content. Other features vary between the services, such as YouTube TV's unlimited DVR, and Hulu's SVOD library. The earlier price increase, coupled with a dramatic slowdown in discount promotions and rising competition had already driven down DirecTV Now subscribers by 168K subscribers in Q2 '19. That brought DirecTV Now's total losses for the prior 4 quarters to 469K subscribers. There's no doubt the new moves will cause more subscriber contraction, as AT&T moves steadily away from the low-cost virtual MVPD model that was its primary initial appeal. High programming costs always meant that turning a profit on vMVPD services was going to be challenging. At one time these seemed palatable as a way of bolstering wireless subscribers (I called it the "video as bait" strategy) and offsetting losses from AT&T's traditional MVPDs U-verse and DirecTV. But AT&T massive debt load, incurred from the Time Warner acquisition, has reduced the company's flexibility to absorb short-term losses (not to mention an activist investor campaign against the company which could lead to the spin-off of DirecTV entirely). Two other new services, AT&T TV (the OTT-delivered DirecTV alternative) and HBO Max (the SVOD service launching next spring) will likely become the company's core bundling methods for wireless. DirecTV Now / AT&T TV Now had a quick 3 year evolution from golden child to unloved orphan. When AT&T reports its Q3 '19 results next Monday, we'll get another update on its falling trajectory. Categories: Skinny Bundles, Telcos Topics: AT&T, DirecTV Now Related VideoNuze Analysis VideoNuze Podcast #476: Can AT&T Put Its Video Puzzle Pieces Together? AT&T Lost Over 1.1 Million Video Subscribers in Q4 '19; Nearly 20% of Base in Past 2 Years

Stephanie Tyler Executive Director of External Affairs, AT&T Western Region Stephanie Tyler serves as the President of AT&T Nevada as well as overseeing the External Affairs operations of a 14-state western region. In this role, she manages the state and local government relations, community affairs, regulatory and legislative activities. Stephanie's 18-year AT&T career in External Affairs includes five years in California and the last 13 in the Western Region. In 2003, she took a one-year leave of absence at the request of California Governor Arnold Schwarzenegger to serve as the Political Director to his successful re-election campaign. Prior to joining AT&T in 1990, Stephanie was appointed to fill a vacancy in the Nevada State Senate representing northern Nevada. She has been actively involved with numerous community boards and commissions in both Reno and Las Vegas. A native Nevadan, Stephanie spent the early years of her career in a variety of political roles including serving on the staff of U.S. Senator Paul Laxalt in Washington D.C. and in his local district offices. Stephanie is a graduate of the University of Nevada, Reno with a degree in political science. She has a gift for humor and is always willing to share her knowledge and experience to grow her team and the leaders around her.

'Regret not completing college education' While the dry and tough living conditions of Gujarat's Banaskantha shaped his social behaviour, his father's involvement in what is now known as 'forward trades' gave him the initial learning. Dt Next Bureau NEW DELHI: He dropped out of formal education at the age of 16 in 1978 to take a train to Mumbai to try his luck and three years later made his first killing - a Rs 10,000 commission doing a diamond trade with a Japanese buyer. That marked the beginning of the entrepreneurial journey of Gautam Adani, now Asia's richest man. He, however, regrets not finishing college, saying early experiences made him wise but formal education rapidly expands one's knowledge. Speaking at the 75th year celebrations of Vidya Mandir Trust Palanpur in Gujarat, Adani recounted his journey that has made his group the world's largest solar power company, largest airport and sea port operator in India, nation's largest integrated energy player, country's second largest cement manufacturer and a conglomerate with market capitalisation of over $225 billion - all in a span of four-and-a-half decades. Adani then moved to Ahmedabad where he spent 4 years completing secondary education. "I was just 16 years old when I chose to give up my education and move to Mumbai," he said. "In this context, a question I often get asked is - why did I move to Mumbai and not work with my family? As many youngsters in the audience would agree, the optimism and desire for independence of a teenage boy is hard to contain. All I knew was that - I wanted to do something different - and do it on my own." He bought a train ticket and boarded the Gujarat Mail to Mumbai with not much in his pocket. "Once in Mumbai, my cousin Prakashbhai Desai enrolled me at Mahendra brothers, where I started to learn to assort diamonds. I quickly picked up and after working there for about 3 years, I left to start my own brokerage in diamond trading at Zaveri Bazar," he said. "I still recall the day I did my first trade with a Japanese buyer. I made a commission of Rs 10,000." This, he said, was the start of his journey as an entrepreneur. "Another question I often get is if I have any regrets that I did not go to college. Reflecting on my life and the different turns it took, I - now - do believe that I would have benefitted if I had finished college. While my early experiences made me wise, I now realise that formal education rapidly expands one's knowledge," he said. "To acquire wisdom, one must experience but to acquire knowledge, one must study." Vidya Mandir Trust Palanpur

Eat Drink and Be Murdered! Only one person knows the secret ingredient to Wild Irish Rose Whiskey, Grandma Rose O'Riley McFadden. Her failing health brings the two feuding sides of her family, the McFaddens and the O'Rileys, together to celebrate her 80th birthday. Each clan hopes Grandma Rose will pass on the secret to the "proper" branch. Keep your eyes and ears open because someone will meet an untimely death tonight, and it's up to the audience to solve the crime! Prizes will be awarded for solving the mystery and for most creative answer!

Assassins threaten to kill Ondo businessman (see text message) The Managing Director of Holyview Investment International Limited, Pastor Babatunde Adebayo, has raised the alarm over threat to his life by some faceless people who called him with foreign-like telephone numbers and sent messages threatening to eliminate him. He disclosed this on Monday while addressing some journalists in Akure, the Ondo State capital on his experience with the callers. Adebayo explained how he narrowly escaped from some men in an unmarked vehicle who trailed him to his church. He called on all security agencies in the state to come to his rescue as the callers were threatening him to vacate his landed property located at Plot 1-18, Alagbaka Extension II, Akure, and his office property at Oke Emeso Street, Akure, Ondo State. One of the messages sent on his mobile set reads: "You are joking with ur life & ur business but you don't know. Very soon, we shall see if the police, DSS & soldiers can protect you in this Akure." When asked why he could be the target of his tormentors, the businessman, who deals in computer hardware and software, said he could not figure out who was after his life. He, however, disclosed that he had a matter pending at the appellate court in Lagos which has to do with a sum of N30 million loan he got from FundQuest Financial Services Limited to fund a contract award. According to him, the financial institution got a ruling against him, his company, and the Guarantor, Pastor Samson Oluwamodede, General Overseer of Prayer Centre, Akure through who he was introduced to the financial institution for the loan. Failing to fully pay back the loan due to the inability of the awarding bank to credit his account with the sum of N113,600,000.00 (80% of the contract value) FundQuest therefore, on October 15, 2014, dragged him, his company, and his guarantor to court, demanding repayment of N88, 721, 137.66 being over 190 per cent (190%) interest rate per annum as against the agreed 30% interest rate per annum. In Suit No: LD/7382/14, on July 2, 2015, Justice O.A. Williams of the High Court of Lagos State in the Lagos Judicial Division, Fast Track Commercial Revenue and Mortgage Division, Court No 22, Igbosere, Lagos, ruled in favour of the finance company despite the contentious interest rate. Subsequently, an enrolment of order was filed by the finance company praying the court to grant it garnishee for payment of N117, 132, 486.21 by Holyview Investment International Limited, which was granted by the same judge, Justice O. A. Williams on 17th day November 2015 bringing the interest rate to over 270 per cent (270%) per annum in just 18 months. Adebayo noted that the restructuring paper on the N34,132,748 dated June 28, 2013, and presented before the court by the finance company, which was hiked to N117, 132, 486.21, on 90 per cent interest rate contrary to the original 30 per cent, was neither signed by him nor his guarantor, yet the court ruled on its paper. He, however, said he had on November 9, 2017, filed a motion on notice at the Court of Appeal in the Lagos Judicial Division, sitting in Lagos, challenging the judgement of the lower court with Appeal No.CA/L/1009M/15 Suit No. LD/7382/14 was granted on November 13, 2018. Previous articleInterception of Doyin Okupe: DSS acted on 'old Watch-list', says EFCC Next article2023: International body wants incoming leaders to address poverty, deprivation

December 8th, 2018 from 6 pm at Grand Hyatt Seoul. The FKCCI Gala is the most iconic and dazzling annual event for the French-Korean business community, bringing together about 800 distinguished guests every year and celebrating the French-Korean friendship. Enjoy the breathtaking decorations and mise-en-scène, an extraordinary course dinner as well as French champagne and wine. The FKCCI has prepared an unforgettable night around the theme "Paris fait son cinéma". Paris has been an open sky theater for some of the greatest movies from many years ago, with a unique romantic atmosphere like you can discover in The Lovers on the Bridge by Leo Carax to provide a very rare setting for some more recent blockbusters, like the last Mission: Impossible with Tom Cruise. Maximilian began music by joining a rock band in college. First with guitar, then with drums, he developed a passion for various instruments and enroled, a few years later, in a music school where he graduated with honor. He then worked for his rock band and recording studio in which he makes albums for various artists. Driven by his entourage, he decided to interpret Bruno mars' song: "When I Was A Man" during The Voice Season 3's blind auditions. He finished second of this contest edition and despite his defeat, he marked the audience with his hoarse voice and interpretations. In 2014, he joined the musical comedy show "Love Circus" and released a year ago, his first EP "Words of They" was released with many covers of women's songs such as "I'm A Man" from Zazie. He currently is preparing his album with his own compositions for next spring. Participate to our quiz challenge! to answer the quiz correctly!

Home » Juliette Lewis Does Anyone Like the 'Jem and the Holograms' Trailer? The trailer for Jem And The Holograms was recently released but it seems like few people think it's truly outrageous and are simply truly outraged.… Jasmine May 13, 2015 'Secrets and Lies' 1.1 Episode Recap and Review: The Trail Who doesn't love a classic case of 'Who done it'? ABC's new crime-series Secrets and Lies has enough twists and turns to satisfy even the… Sirraya March 25, 2015 Molly Ringwald, Juliette Lewis Sign On For 'Jem and the Holograms' Fans of the 80s, rejoice! Earlier this week, Deadline reported that real-life rocker Juliette Lewis was cast in the upcoming Jem and the Holograms flick and now fans are treated to… 'August: Osage County' Review: The Must-See Cast of the Year Tracy Letts' August: Osage County takes place in Oklahoma - plains country - as Julia Roberts' character Barbara so fervently points out. alexandracp January 10, 2014 Juliette Lewis Hospitalized After Hit-and-Run Crash Singer-actress Juliette Lewis was briefly hospitalized Wednesday night in after another driver broadsided her Lincoln Town Car and then fled the scene… SuperMommy October 8, 2010 Orlando Bloom And Juliette Lewis Form Band For Movie ORLANDO BLOOM and actress-turned-punk rocker JULIETTE LEWIS are to debut their new movie band at an afternoon concert in Los Angeles on Thursday (05Feb09). The… FanBolt February 4, 2009

. Even Females go ashore and carry guns. Two recent British War Films about ordinary soldiers that are well worth watching. The true story of what happened at Kajaki in Helmand Province in Afghanistan with a 100% rating on Rotten Tomatoes and '71 about a young soldier in Northern Ireland in 1971, it has a 96% rating. Another series of excellent BBC stories of "regular soldiers" is the 3-movie series "Our World War." It's basically about the old concepts of nationalistic war glory coming face to face with the reality of modern mechanized combat and the real nastiness that was always war. Each movie is set around real combat events of real soldiers--each story is built on the letters and memoirs of a real-life British soldier in WWI. Their stories are about actual battles, with the production using both Private-Ryan-style hand-held camera effects and Ken Burns-style pull-backs to show what's happening in the larger scheme. The first soldier was part of a machine gun squad directed to hold a bridge, the first demonstration to a cocky set of troops that combat is nasty and scary, and nobody will be the same afterward. The second is of a man who will be part of firing squad to execute a fellow soldier for cowardice--knowing that it could as well have been him. The third is of a crew of one the early battle tanks trying to get through enemy territory to join up with a planned battle. I like how at the end of each story the pull-back showed the futility of the horror of the story itself, such as a day of hell ending in a gain of only a few feet of territory. Unless it's a true story of a cook becoming something (men of honor) or say Hacksaw ridge or Unbroken etc most military jobs are typically support those jobs which are mundane and not exciting. I'm not taking away anything from military folks but it's impossible to make a exciting movie about say a military kitchen staff, office clerks or motor pool. I guess you can watch a bunch of cooks go tactical on a pot of baked pork and beans. I mean imagine Darth Vader as the Chief Cook. "This sauce is tooo spicy, open up another can" I think there could be a decent precautionary tale told about the combat defeat of the 507th Maintenance Company, 5/52 ADA BN, 11th ADA Brigade (Jessica Lynch's unit). Their story begins with the unit being out by itself without the rear-guard support it should have had by Army logistical planning (Rumsfeld didn't think all those other troops were necessary). The lightly armed maintenance unit spent several days desperately trying to stay under the protection high-speed combat maneuver units, but just couldn't keep up. It fell behind in territory still under the control of the enemy (Rumsfeld didn't see a need for extra troops to hold on and pacify territory after the invasion front had passed through--he and Cheney claimed the Iraqi troops would support the US, as soon as they saw we were the good guys). I think there is a story in a unit strung out in a situation it was never trained, equipped, or intended to handle. Yep, very good movie and I served in the Army. Seemed pretty real. Saving Private Ryan was not about a spec ops team, and nor was Band of Brothers. Fury with Brad Pitt was also not spec ops. The Last Ship on TNT is not a spec ops team. Mash was not a spec ops team. Jarhead was not a spec ops team. Hurt Locker was not a spec ops team. Battle LA was not a spec ops team. Battleship with Taylor Kitsch was not spec ops team. Because combat has changed, most of the killed and wounded are now form IED's not from actual assault missions. We have learned from Vietnam that gorilla type units are a better use of personnel. Since war type films today are more BS than factual, even if loosely based on some event. Using a secretive spec. ops. unit with your usual members as the main subjects can make for a more compelling story. Since they are secretive, you can place the unit in any scenario, no matter how over the top.

Monaco Ocean Week The restitution book 2018 Press content The high-level United Nations Conference to Support the Implementation of Sustainable Development Goal 14: Conserve and sustainably use the oceans, seas and marine resources for sustainable development will be convened at United Nations Headquarters in New York from 5 to 9 June 2017. The Prince Albert II of Monaco Foundation presents an action on 9 specific objectives. Prevent and reduce marine pollution (#14-1) At the initiative of the Prince Albert II of Monaco Foundation, BeMed is providing support to local projects focused on pollution in the Mediterranean. The association aims at developing a network of NGOs, local communities, scientific institutions and private stakeholders working to combat marine pollution. Sustainably manage and protect marine and coastal ecosystems (#14-2)In the framework of the RAMOGE Agreement signed in 1976, Monaco, France and Italy have implemented a tool for scientific, technical, legal and administrative cooperation to take action for integrated management of their coastline. The Pelagos Agreement signed in 1999, protects all marine mammals and their habitats from threats caused by human activity. It is managed by France, Italy and the Principality of Monaco, which hosts the Permanent Secretariat. The Agreement on the Conservation of Cetaceans of the Black Sea, Mediterranean Sea and Contiguous Atlantic Area (ACCOBAMS), signed in 1996, embodies riparian countries' commitment to preserve all species of cetaceans and their habitats by applying measures to mitigate impacts of economic activities. The Principality of Monaco's two marine protected areas launched in 1976 and 1986 are established in a highly-urbanised environment, providing in-situ laboratories for scientists. They are managed by the Monegasque Association for Protection of Nature (AMPN). Ocean acidification (#14-3) The Monaco Ocean Acidification Association (AMAO) brings together Monegasque institutions and international bodies to put forward solutions for adapting to acidification. Restore fish stockss (#14-4)The Government of Monaco and the Prince Albert II of Monaco Foundation launched in 2010 a call to the CITES concerning the risk of extinction of the bluefin tuna which raised awareness of all the stakeholders in the sector. Today they all recognise that the stocks are recovering. The Monaco Blue Initiative, co-organized by the Prince Albert II of Monaco Foundation and the Oceanographic Institute is a think tank which brings together scientists, economists and policymakers, drafting analyses and recommendations on the links between MPAs and economic activities such as fishing and aquaculture. Conserve at least 10 per cent of coastal and marine areas (#14-5) The Governments of Monaco, France and Tunisia, together with the Prince Albert II of Monaco Foundation, have established a trust fund to strengthen and develop MPAs in the Mediterranean. The fund's priority is to improve effective management of these MPAs by funding ongoing administration costs. Sustainable use of marine resources in small island states (#14-7) The Prince Albert II of Monaco Foundation supports projects for the sustainable use of marine resources in small island states such as Palau and Kiribati. Increase scientific knowledge (#14-a) The Monaco-based Mediterranean Science Commission (CIESM) has supported multilateral marine research in the Mediterranean and the Black Sea since 1910. It now has 23 member states. The Scientific Center of Monaco studies tropical and Mediterranean coral ecosystems and the impact of global climate change on oceans, including acidification. The 2017–2020 Monaco Explorations initiative, recently launched, will conduct research and scientific outreach projects on seas and oceans in the world. The Government of Monaco and the Prince Albert II of Monaco Foundation initiated the recommendation submitted to the IPCC to produce a Special Report on Oceans and Cryosphere in a Changing Climate. The scoping meeting for the report was hosted in Monaco in December 2016. Provide access for small-scale artisanal fishers to marine resources and markets (#14-b) The Prince Albert II of Monaco Foundation coordinates the Mr Goodfish programme in the Mediterranean. Its goal is to raise awareness among the public and professionals regarding the challenges of sustainable consumption of seafood products, encouraging consumers to buy fish caught by artisanal fishers. Sustainable use of oceans by implementing international law (#14-c) Monaco participates actively in discussions on the development, within the framework of the United Nations Convention on the Law of the Sea, of a legally binding international instrument on the conservation and sustainable use of marine biodiversity in regions located outside national jurisdictions. Share the site 2017 © Monaco Ocean Week I Conditions d'utilisation I Conception et réalisation : Terms of use I Design and production : DCS-T2BH

Insights into Sweden's forests 1 March 2023, 12:30-14:30 CET (Brussels time) The Press Club Brussels Europe Rue Froissart 95, 1000 Brussels Please register before 17.00 on Monday 28 February. For the next six... Biodiversity and Carbon Neutrality: The role of EU law The European Commission has outlined pathways to carbon neutrality in 2050 all of which require negative emissions. The most cost-effective, readily available negative emission comes from forests and other ecosystems, which absorb... Biodiversity offsetting (1) Land Use, Land Use Change and Forestry (LULUCF) (2) Sustainable Supply Chains (12)

Campus news and events for HCU students, families, faculty, and staff. Houston Christian University (HCU) is among the first of five area universities offering mentorship opportunities to students through PartnerUp Houston, a regional initiative launched by Greater Houston Partnership (GHP) in collaboration with Mentor Collective, a national mentorship organization. … HCU McNair Center for Entrepreneurship Hosts Inaugural Pitch Fest HCU's McNair Center for Entrepreneurship and Free Enterprise joined forces with St. Thomas University's (STU) McNair Center for Free Enterprise and Entrepreneurship to host the first-ever Pitch Fest on the Houston Christian University campus on Dec. 2 in … HCU hosts ribbon cutting to celebrate opening of "The Corner Pawket" HCU students have a new space to study, play games and just hang out as University officials, staff and students gathered for a special ribbon-cutting ceremony on Nov. 9 to celebrate the grand opening of "The Corner Pawket." … Jim McIngvale delivers keynote speech at Dr. Dawn K. Wilson Teaching, Learning + Research Symposium The 2022 Dr. Dawn K. Wilson Teaching, Learning + Research Symposium will feature Jim "Mattress Mack" McIngvale as the keynote speaker for this year's themed event, "The Magnificent Seven: Creativity | Collaboration | Communication | Critical Thinking | … Dr. Robert Sloan on HBU's core values, successes and plans to come Almost exactly one year ago, on September 9, 2021, the final draft of The Ten Pillars 2030 was completed, and on Sept. 21, 2021, the vision document was adopted by the HBU Board of Trustees. The original Ten … Huskies Give Big 2022 supported by Matching Gift Challenge from Alumni Donor Houston, Texas, Aug. 4, 2022 – Houston Baptist University (HBU) will host its annual Huskies Give Big campaign on Aug. 31 and Sept. 1, 2022, to invite alumni and University friends to join forces to provide students with … HBU Huskies 2022 Football Season Tickets On Sale Now! The 2022 football season is drawing near! Season tickets for the HBU Huskies' five home games are available now. Secure your spot at Husky Stadium to cheer on the HBU Huskies Football Team as they kick off the … HBU Signs Guaranteed Admission Agreements with Local Community Colleges Houston, Texas, June 30, 2022 – Houston Baptist University (HBU) is making higher education more accessible to transfer students in Texas-based community colleges. The University recently signed agreements with several local community colleges, including Houston Community College, Alvin … HBU Alumnus named 2022 Trial Lawyer of the Year Houston Baptist University alumnus, Randy Sorrels has been named 2022 Trial Lawyer of the Year by The Texas Chapter of the American Board of Trial Advocates (TEX-ABOTA). Sorrels graduated with a Bachelor of Arts in Speech Communication & … HBU presents 2021-2022 Mayfield Awards Two Houston Baptist University (HBU) staff members have been named 2021-2022 Mayfield Award honorees. The award was named to honor Dr. Ray V. Mayfield, Sr. and, his son, Dr. Ray V. Mayfield, Jr. who both served the University … Christian University in Texas Career Fairs ROTC Programs Team of Christian University in Texas

The Mercedes-Benz SLS AMG GT final edition has been revealed ahead of LA Motor Show 2013. Mercedes will manufacture a limited batch of 350 cars before it gets face lifted next year. Mechanically the car remains the same as SLS AMG. It is powered by the same 6.2 litre V8 engine that churns out 591bhp and 650Nm of torque. Power is transferred to the wheels via a 7-speed Dual clutch transmission. The car gets a carbonfibre hood and front splitter, new alloys, new bumper and new ceramic brakes. The rear wing and the carbonfibre mirror are also updated. "Thanks to the wide variety of models – from a gullwing model to the roadster, GT, the Black Series, an electric drive and its success in motorsport as the GT3 variant – the SLS AMG has become ever more attractive and is now one of the legendary dream cars from the brand with the star," said Mercedes.

May 2012 e-Newsletter Boroughs Publishing Group News Boroughs Opens Its First Romance Short Story Contest: @ FIRST SIGHT In one blink of an eye, you're hooked. "OH, HENRY!" she said. "Is that an e-reader in your pocket, or are you just feeling romantic?" Looking to get noticed? Boroughs is offering a great opportunity for you to show off, whether you're published or unpublished, whether you're a first-time author or have a trunk full of novels under your bed. Short fiction is the simplest of all art forms—and the trickiest. With a limited amount of space to show us your world, your characters, their conflict…and then prove why they just have to be together, you have to be smart, be sexy, be different. And it has to happen in the blink of an eye. Think you can succeed? We know you can. TELL YOUR FRIENDS, TELL YOUR NEIGHBORS, THE CONTEST HAS BEGUN! The contest opens today and closes 11:59 p.m. PST, July 1st 2012. TO SUBMIT Send the following to [email protected]: a short ROMANCE story of 6,000 to 10,000 words, double spaced, Times New Roman 12 point, with one-inch borders, submitted in MS Word. Please put your story title in the header flush right. Please DO NOT put your name on the body of the story, as the rounds will feature anonymous judging, but in your query letter include your name and contact information, the story title and its suggested sub-genre. In the subject line of your submission email, please put "@FS: [YOUR STORY TITLE]" "the pitch": a 15 to 25 word encapsulation of the story. Be brilliant. You will be judged on this! Remember, the contest is open to published and unpublished authors alike. And you may enter more than once, but please submit each story separately. Each story should be self-contained enough to feature a resolution of any inherent conflicts and provide at least a happy-for-now ending. Looking for a place to get started? Here's a thought: Use side characters of your previously written novels or back story connections of your characters that part and meet again. PHASE 1: On July 3, 2012, story titles and pitches will be posted ANONYMOUSLY on our website for open voting. Those that receive the top 25% of the vote in their sub-genre will be selected as SEMI-FINALISTS to go on to… PHASE 2: On July 17, 2012, the story's first page (or first ~250 words) will be posted ANONYMOUSLY on our website for votes along with the title and pitch. In addition, our Editors will weigh in. The top three stories in each sub-genre will be selected as FINALISTS to go on to… PHASE 3: On July 24, 2012, the first three pages of the story will be posted for voting. Bit by tantalizing bit you'll see who has what it takes—and so will we. The announcement of the winner of the @ FIRST SIGHT contest will be made at 5:45 p.m., Friday, July 27, 2012, at our Publisher Open House at the RWA convention in Anaheim, California, and the results will be Tweeted and publicized on our website. Beginning on July 3, 2012, and for each phase of the contest, you and everyone you know should visit www.boroughspublishinggroup.com, find the link to the @ First Sight contest, then cast your votes for stories that tickle your fancy and make you want more. You may vote for every story you like. ALL FINALISTS will be offered: A contract to have their story published and sold by Boroughs Publishing Group A full editorial process to make their story shine THE FINALIST with the most popular website votes will be offered: A critique by an editor of a full-length manuscript submission to Boroughs, with a turn-around time of two weeks THE WINNER, chosen from our FINALISTS by our editorial staff, will receive: cover art specifically tailored to the story A critique by our Editor-in-Chief of a full-length manuscript submission to Boroughs, with a turn-around time of two weeks 75% of the winning story's net royalties Boroughs Joins Publishing Against Diabetes Boroughs Publishing joins numerous industry professionals, authors and publishers alike, in the fight against diabetes, donating to the annual online auction run by New York Times bestselling author Brenda Novak. Boroughs has offered up: Critiques of three (3) FULL manuscripts within a two (2) month turnaround, 1 of which will be critiqued by Editor-in-Chief Chris Keeslar; Critiques of five (5) partial manuscripts—the first five chapters—with a one (1) month turnaround, 2 of which will be critiqued by Editor-in-Chief Chris Keeslar; and Ten (10) copies each of our debut author's books, Tumbleweed Heights, Nobody's Angel and The Genie Ignites. Boroughs is just one of a multitude of donors. Since its inception, this annual auction has raised over $1.3 million (cumulatively), and they're looking to break $2 million in the near future. The auction is open at this very moment and will run through May 31, 2012. This year they're even giving away a free iMac or PC of equal value to the person who makes the most bids, regardless whether that person wins the most items. So, make some bids! Let's go cure some diabetes! http://brendanovak.auctionanything.com Boroughs About Town (& Country) In Anaheim For those of you who don't know, the Romance Writers of America national convention will be held this year in California, at the Anaheim Marriott, July 25th - 28th. For those of you attending, Boroughs invites you to join us for the following events in our Hospitality Suite – Room #355 at the Anaheim Marriott: Friday, July 27, 2012, 4:30 to 7:30 p.m. Boroughs Spotlight, Author & Editor Meet & Greet and Open House At 5:45 p.m. we will announce our @ First Sight Contest winner! Saturday, July 28th, 9 a.m. to 11:30 a.m. Author Pitch Sessions Sign up on our web site! RWA remains the best single resource for aspiring romance writers, bringing together authors, editors and all types of publishing professionals. For information about the conference, go to: http://www.rwa.org/cs/conferences_and_events. For information about RWA or a chapter near you, visit: http://www.rwa.org/cs/about_rwa. In Toledo Boroughs was invited to spend an afternoon with the Maumee Valley chapter of Romance Writers of America in Toledo, Ohio, on Saturday, April 28th. (Thanks, ladies!) The MVRWA chapter boasts a fantastic mixture of published and unpublished authors, and all present agreed it was one of the best and most informative meetings in recent history. For those of you who can't pick him out, that's our Editor-in-Chief on the far left. Liz Edelstein from Heroesandheartbreakers.com was also in attendance. Interested in having Chris or someone from Boroughs visit your chapter? Send a request with event details (including date) to [email protected]. Romantic Times Book Reviews interviewed Editor-in-Chief, Chris Keeslar and wrote: Video Interview: Editor Chris Keeslar By RT Book Reviews, May 17, 2012: Chris Keeslar planted his publishing roots as an editor at Dorchester Publishing, where he spent many years working with authors including Marjorie M. Liu, Victoria Alexander, Lynsay Sands and more. Now, Keeslar is spearheading the new Boroughs Publishing Group, an e-book house, where he will continue his practice of taking chances and discovering new author voices. RT's Morgan got a chance to talk with Keeslar about his new endeavor and find out what Boroughs is looking for and how authors can submit their manuscripts. So what does Boroughs want? Keeslar shares that an author's vision is key, and while he's partial to urban fantasy and paranormal romance stories, he wants books that give their hero and heroine a happily ever after. Ultimately, romance is near and dear to this editor's heart, and we can't wait for what's on the horizon for Boroughs. You can watch the entire interview at RT's Daily Blog: http://www.rtbookreviews.com/rt-daily-blog/video-interview-editor-chris-keeslar and on YouTube at: http://www.youtube.com/watch?v=RVgkXb6ZtQU. E-Musements A short monthly piece to show what's happening in the editor-in-chief's brain...and in his office. Besides reading. Lots of reading. Advice: Pitch Your Voice I spent the other weekend in Toledo talking about all the changes occurring throughout the publishing industry. Wow, there are a lot. It can be daunting, really, as much as exciting. But one thing I'm happy to report will never change. First and foremost, regardless of your experience level or the innovations of product delivery, writing is about communication. So, as a writer, focus on that: Communication. Your key to success is conveying everything you want to convey to the appropriate audience in the appropriate manner—a manner you've determined by listening to them before you speak. Know who you are. Know who they are. If you don't know who your audience is, it's you. At least, that's a great place to start. You're most likely writing for someone who has the same tastes as yourself but doesn't have the same drive to create. That makes things easier, no? Start thinking about the elements that work for you when you're reading. What really makes you gasp, groan, sigh or buy the next thirty installments of the series? Can you do the same? Next start thinking about what you'd do, how you would have characters act differently in similar situations and how you could make a story even more romantic than the best book you ever read. Don't look now, but you're finding yourself. You're finding your Voice. Not as tough as you thought, eh? When authors or teachers or editors tell you to "Find your voice," they're not just talking about what words you use and how you naturally arrange them; they want you to discover that inner core of yourself that makes you write, what it makes you write and why. Your Voice is what's quintessentially you. It's what you as a writer offer the world. It's your soul: unique, immutable, beautiful. People—aspiring authors in particular—are guilty of a serious crime: They elevate writing to a Herculean task. Well, maybe it is one. But the strenuous part comes from committing to and believing in your vision while still paying attention to your audience, connecting their hopes and dreams to your own. But it makes the task easier to delineate: Become a good communicator, you'll be a good writer. Amusingly, I find authors who have tackled the task of writing a book then shy away from something as simple as a pitch. There's no good reason. If you can do one, you can do the other. A pitch is just using your Voice to tell a friend why they should read a book, see a movie or listen to a song. That friend just happens to be an editor, and the book just happens to be yours. You should know better than anyone what makes it awesome. Where you get to hear the people who make publishing–and Boroughs especially–what it is. Author Introduction: Staci Weber & Sara Dailey Staci Weber & Sara Dailey are avid readers, English teachers, friends, wives and soccer moms. They have been teaching together for the past eight years and writing together for four. Pack of Lies is their second young adult novel. We want to start by saying how excited we are to be working with Boroughs. We could not be happier with the way our book turned out, and to have a group of professionals so enthusiastic about the story assures us that our baby is in good hands. We were so nervous! We wanted to write a series, much like some of our favorite adult paranormal romance series, where each novel is from the point of view of a different character—or characters as it happens in Pack of Lies. About a third of the way into the manuscript we decided to use three different first-person POVs. We feared the series would be a tough sell for a few reasons. One, it's about werewolves, and two, it's told in those alternating points of view. But we forged ahead regardless. It was the type of series that we wanted to read, and we simply hoped that others out there would too. Judging from feedback, you do! So, we were asked today—and it's a question we get a lot—how two people manage to write same story together. Well, four years ago, when we started our first novel, we had absolutely no idea how it would work or what we were in for. We just sat down with one laptop and passed it back and forth until the book was finished. This is probably why it took us over a year to write! Since then we have changed things a bit, but some things remain the same. We still try to meet at Starbucks once a week to plan, organize, and write together. The only real difference is that now we each have our own laptops, and we each write our own chapters. Forward progress! We have run into a few problems along the way—like finding time between school and soccer games to get together to write or make our individual chapters flow together—but we always find a way to make it work. Our passion remains strong. One of the first and hardest things we learned about writing together was that we have to be honest. If something isn't working or just doesn't sound right, we have to speak up about it and not let our feelings get in the way. Luckily, we have been friends for quite a while and are comfortable enough with each other to speak our minds. Despite the problems, writing as a team has been an absolute blessing. We can't imagine writing without each other. When we get a good review, we can celebrate together; when we get a bad one, we can talk trash together. We give each other the confidence to get our work out there for people to read, which can be really scary, but no matter what, when you're part of a team you get to have twice as much fun. And that's what writing's all about. Having fun. Thanks—and we hope you enjoy Pack of Lies! Boroughs at RWA Anaheim RWA Conference - San Antonio January 2020 e-Newsletter December 2019 e-Newsletter November 2019 e-Newsletter October 2019 e-Newsletter September 2019 e-Newsletter August 2019 e-Newsletter July 2019 e-Newsletter April 2019 e-Newsletter March 2019 e-Newsletter February 2019 e-Newsletter

Q: Allow pfSense to route from LAN to WAN devices New to pfSense. My pfSense WAN = 192.168.1.50 (DHCP from my home router) My pfSense LAN = 192.168.55.0/24 My Cisco switch = 'Default VLAN1 with 192.168.55.254` I can ping from 192.168.55.0/24 devices to any device at 192.168.1.0/24. However, I can only access the pfSense firewall at 192.168.55.10 from 192.168.1.0/24 but not the devices on 192.168.55.0/24 network. Here is the simple topology: Laptop can't ping PCs on the LAN but LAN PCs can ping my laptop... What am I missing?

This season's wardrobe staple? Renewables. Wind Solar General News It's no secret to anyone that the fashion industry is one of the biggest energy users in the industrial sector. However, some manufacturers are making strategic, targeted changes to the way they consume energy both in their warehouses and factories. We cut through the cloth to bring you the trend setters that extend way beyond the seasonal shelf life. Once you put its trendy activewear, impressive marketing strategies and cult following aside, Nike has laced up its sneakers and has been playing the long game when it comes to renewable energy. Being no newcomer to the world of power purchase agreements (PPAs) or self-generated renewable energy, Nike has upped the ante when it comes to how much renewable energy its sources, signing a second major wind contract with Avangrid Renewables to purchase 86 MW of Texas wind power. But the real sweetener in this deal is that it means that Nike now gets 100 per cent of the energy at its North American facilities from renewable sources. The power purchased from this agreement alone is enough to power over 400,000 average American households and delivers emissions reductions that are equivalent to taking 800,000 vehicles off the road for a year. It doesn't matter if you're a Mom, skinny, super high, mid or low-rise jean sporter, we can all agree on making our jeans work for more than just our body type – and luckily Levi's knows a thing or two about this. Despite having been around since the 1850s when it invented the humble blue jean, the brand has consistently reaffirmed its responsibility to reduce its environmental impact as a fashion retailer. Aside from using its household name to advocate for strong climate policies, Levi's has begun to prepare for a low-carbon future. The company currently has a Climate Action Strategy in place which aims for the following by 2025: 100 per cent renewable energy in all owned and operated facilities 90 per cent absolute reduction in greenhouse gas emissions in all owned and operated facilities 40 per cent absolute reduction in greenhouse gas emissions across its global supply chain. So the next time you buy a pair of Levi's, you can do so without guilt because this denim is trendier than ever before thanks to the help of renewable energy. Founded in 2000, this British online fashion manufacturer and retailer is a haven for young adults. However, put their 850 brands aside and you'll see that ASOS is making key changes in its business functions to lower energy usage both at its HQ and factories. ASOS Studios – the place where they capture each garment you see online – gets 100 per cent of its energy from a solar system that produces 30,000 kWh of clean energy per year. The company has also replaced the lights in its warehouse with LED globes to reduce energy consumption and has reduced the carbon footprint from each order by 26 per cent year on year. On the manufacturing front, the business requires all factories that it uses to declare how much energy and water they consume and how much waste they emit. From these numbers, ASOS then works directly with its suppliers to bring the numbers down – all while ensuring that employees are both paid a living wage and are working in safe conditions. Swedish fast-fashion giant H&M has acknowledged the impact that fast-fashion is having on the environment by taking steps to reduce its environmental footprint. The fashion retailer has signed on to RE100, a global corporate leadership initiative bringing together influential businesses that are committed to using 100 per cent renewable energy to power their operations. Currently, the brand derives 96 per cent of its energy from renewable sources. From a supply chain perspective, H&M has two clear targets for its major suppliers: 100 per cent of factories being enrolled in an energy efficiency program by 2025 30 per cent of greenhouse gas reduction per product by 2025 in comparison to the 2017 baseline. When combined with its commitment to 100 per cent renewables in its operations, these targets will enable H&M to drastically reduce its environmental impact while transitioning to a cheaper and cleaner way of keeping the lights on and the store doors open. Buying renewables the new way to get businesses back in the black In conversation with Women in Renewables Scholarship winner Heidi Sick

Irish Yeast Co sells to Doyle's pub for €850,000 Listed property was one of Dublin's oldest businesses and best-known shopfronts Tue, Aug 14, 2018, 13:00 Updated: Tue, Aug 14, 2018, 14:35 Madeleine Lyons The Irish Yeast Co opened in 1894 in what had been the foyer of the George Hotel. One of Dublin's oldest businesses and best-known shopfronts, the Irish Yeast Co, has sold for an estimated €850,000. It is understood that the historic listed property, sandwiched in a prominent row of buildings opposite Trinity College on College Street, was purchased in recent weeks by Doyle's pub, which operates a large premises on the same block . Number 6, located between the Westin Hotel and Doyle's, dates from 1750 and was placed on the market less than six months ago when a large "Investment Opportunity" sign was placed over the door. The asking price at the time was €675,000, with up to eight bidders eventually driving the price upward. The sale of the Irish Yeast Co marks the end of an era for the 130sq m (1,399sq ft) premises that, up to two years ago, steadfastly continued to trade its specialist baking products long after big name retailers had all but consumed the city centre's traditional shopping streets. Reeling in the yeast – An Irishman's Diary about Dublin's most enduring shopkeeper Johnny Ronan made an offer they 'had no difficulty refusing' Its sale through estate agent Alan Denihan of DNG followed the death of proprietor John Moreland, who operated the business and lived overhead for more than 60 years. When the four-storey property went on the market in February, Mr Denihan described the building as "a time capsule. It's like a set from Strumpet City." The late John Moreland, owner of the Irish Yeast Co. Photograph: Frank Miller The business first opened in 1894 in what had been the foyer of the George Hotel, which later became a bank and subsequently reverted to what is now the Westin Hotel. Listed structure As a listed structure, the development opportunity for the building is limited, although its location alongside the existing Doyle business will have strategic appeal for owner Declan Doyle. The Carlow businessman also owns Bowe's pub, one of Dublin's last original Victorian pubs, and a former Ladbrokes betting shop both located directly behind the Dublin Yeast Co and adjoining Doyle's pub. Since 2014, Mr Doyle has sought planning permission to incorporate the betting shop into Bowes and expand the entire area into Doyle's. The Dublin Yeast Co frontage would deliver better and more prominent access from College Street to any reconfiguration of these premises, than the existing access from quiet Fleet Street to the rear. Mr Doyle could not be contacted for comment. The four-storey building was sold with contents in place, including a vast array of baking paraphernalia – foil-covered cake stands in all sizes, faded bunting and old style bride and groom figurines with hand-written price tags. John Moreland College St What will €299,000 buy in Walkinstown and west Cork? Victorian country house in Tipperary with 50 acres for sale for €1.9m Design Moment: Tulip table, 1958 Institutional investors: villains or heroes of housing woes? Conor McGregor buys home of former taoiseach's son for over €2m What sold for around €484k in Ringsend, Drumcondra, Blackrock and Glasnevin New Ballsbridge home being lined up for Israeli embassy Claiming an exemption from property tax? Now you must prove it What you can buy for €275,000 in Greece, Italy, France and Co Carlow Take5: A bungalow in Carlow town or a period house amid cognac vineyards 2:30 €2.25 million for solicitor Gerald Kean's home in Wicklow 3:49 Identical twins look back on 'wonderful' childhood in a Kilkenny castle 1:22 Luxury rental apartments launched in Hanover Quay, Dublin 2:48 €3 million for Ballsbridge home full of unusual architectural detail 7:29 A personal tour through Michael Flatley's mansion Make a move to Dublin's secret sought-after streets 'I left my job because it was boring and now I regret it' 'The baby cries now and you don't even cry along with her. A truly magical milestone' New phase of Millerstown family houses in Kilcock launching now Hooke & MacDonald and Coonan New Homes launch the latest phase of McGarrell Reilly Group's large semi-detached and detached houses at Millerstown, Maynooth Road, Kilcock Most Read in Life & Style 3 When your time is up, I hope you drop like the dead donkey 4 Conor McGregor buys home of former taoiseach's son for over €2m 5 Agencies in Ireland ignored the experience I had gained in New Zealand 6 Parents are being 'eradicated from the lives of their children for no good reason' 7 Irish in London attend funeral of man with no mourners 8 Undocumented Irish in America: 'Come in legit or stay at home' 9 Cycling matters: 'Young women feel judged to be on a bike' 10 Yotam Ottolenghi's genius fish pie

Adversity doesn't slow down former Flower Mound athlete By Steve Gamel Courtney Fields inspires others to overcome difficulties by her display of faith, hope and determination. (Photo by Lynn Seeden/Seeden Photography) Courtney Fields woke up feeling cold, and she couldn't for the life of her understand why she only had one sock on. Seconds earlier, the 24-year-old Flower Mound native and former basketball star had asked her mother, Shanta, to please grab the pair of comfy socks next to the hospital bed and put them on her feet. Like any doting mom, Shanta immediately went to the right side of the bed and slipped the first one onto her daughter's foot. But then she stopped. "I remember saying, 'OK — are you going to put the other one on?'" Courtney said. "That's when she said, 'Baby, you don't have a leg. They took it to save your life.' She said a nurse told me earlier, but that's how I remember finding out." Courtney had just undergone eight surgeries and an emergency above-the-knee amputation of her left leg because of a previously undetected blood clot that almost killed her. The entire time, she was in a medically-induced coma. Her journey started in late February, and she ultimately spent 28 days in ICU and a grand total of three months at Medical City Dallas. Most people would have been overcome by a riot of emotions at that moment — devastation, anger, confusion, and even resentment. This was especially true in Courtney's case, as none of this would have happened had she not elected to undergo a double mastectomy and breast reconstruction to avoid being the next in her family to get breast cancer. "I was doing what we all thought was right," she said of the mastectomy in early February. "What the doctors didn't know at the time was that I had a blood clot. Had they known, they could have gone in and removed it, and none of this would have happened. "When you're making your 10- or 15-year plan for life, you don't insert an amputation in there. But I'm alive." Rather than give up, Courtney is adapting to her new normal with grace and a level of confidence that has inspired friends, family, doctors, and complete strangers. She was released from the hospital in May and now wears a prosthetic leg. In November, she wrapped up a customized 9-week training course through the Adaptive Training Foundation in Carrollton. ATF is a nonprofit that started in 2014 to provide access and inclusion to individuals living with physical or traumatic impairments by empowering them through exercise and community. "It's usually at least a year or more before someone is physically able to come in here to ATF and start training," said Chris Jones, an assistant trainer at ATF. His daughter, Carley, had been good friends with Courtney since middle school. "Courtney left the hospital in May and started here in September. The courage she has shown is impressive." Courtney was the youngest person in her class and is now looking confidently toward her future. "I could be positive or negative about this experience. I choose to be positive," Courtney said. "I'm 24 years old. I have what I think is a lot of life to live, so I don't plan on letting this stop me." "I was living my best life" Fields grew up here and graduated from Flower Mound High School in 2015. Not only was everyone her friend in those days, but she had a smile that could light up any room. On top of that, she was an amazing athlete. A soccer and basketball star, she chose only to play basketball in high school and was a shooting guard on the 2015 Lady Jaguars' team that beat Plano West to advance to the Class 6A state tournament. Though they didn't win it all — they lost in the semifinals to Dallas Skyline — Courtney earned a scholarship to Texas A&M-Commerce. She played three years with the Lions and eventually graduated with a Bachelor of Science in global e-learning (now higher education and learning technologies) and a Master of Science in higher education. "Honestly, I was living my best life," she said. "I was young, going to Dallas every weekend, and was having a great time. I had just completed my master's degree and was already working full-time as an academic advisor for the university." Deep down, however, Courtney knew she was on borrowed time and needed to have a very important surgery. When she was 12, doctors confirmed that she had a mutated gene that comes with a higher risk of breast cancer. Courtney's mother had breast cancer. Her grandmother was previously diagnosed with it. Even her dad's sister had breast cancer. Doctors explained that she could preventatively have a double mastectomy and breast reconstruction later on in life. "At 12 years old, I was like, 'Let's do this right now. I'm ready,'" Courtney said. "We all knew that I was going to get it at some point, but they said I had to wait to have surgery until I was at least 24. Fast forward 12 years — I'm 24 years old and was trying to do what I thought was right, which was to prevent breast cancer." What happened next was something Courtney and her family never expected. She had her double mastectomy and reconstruction in early February, but a complication with one of her breasts kept doctors from finishing the procedure. A follow-up surgery along with the reconstruction was scheduled for February 16. Everything appeared to be fine, that is, until Courtney became ill six days later. "I don't remember any of it, but my parents said I had a hard time breathing," she said. "They called 911, the paramedics checked all my vitals, and I was fine. But something just didn't seem right, so I asked to go to the hospital. Even on the ride to the hospital, they didn't have the sirens on — because they didn't think anything was seriously wrong." Within minutes of arriving at the hospital, Courtney's heart stopped. Doctors revived her, but she coded two more times after that. It was then that doctors realized she had an undiagnosed blood clot, and the chest compressions from trying to revive her had caused it to burst and spread throughout her body, she said. CareFlite took Courtney to Medical City Dallas, and her parents had to make a life-changing decision. "My friends couldn't understand why I wasn't screaming and yelling and sad over the fact that I lost my leg," Courtney said. "But I always looked at it as the right decision. Had they not done it, I wouldn't be here right now. I couldn't imagine being my parents in this situation. This was during COVID-19, so I only got two hours a day with them, and they had to alternate. They even stayed in a hotel next door." Adapting to a new life Courtney may not have heard of the Adaptive Training Foundation had it not been for a chance encounter while being fitted for her prosthetic leg. An older gentleman mentioned ATF as a potential option. "As he explained what it was, I knew I had to get in. And by the grace of God, I did," she said. "The workouts are catered to our needs, and you learn how to adapt. I needed someone to push me, but this place has always been more than just the physical part. They help you with the mental part, too. We focus a lot on breathing, and we talk a lot of things out. You're around others who have been through similar struggles, and that's important. My parents have been great, but there are just some things they won't get. "I'm around people who are just like me. It's a special place." Phil Quintana, a trainer at ATF, agreed and added that he's never been more proud of Courtney. "Everything we throw at her, she's got it," Quintana said. "She's awesome. She's on her game." Courtney said one of her immediate training goals is to get to a point where she can walk fluidly without a limp and regain her independence. She's already driving again and has learned to care for herself without help. But eventually, she'd like to move out and go back to work. "I'll be 25 in December, and it's important to me that I get back out there and do what 25-year-old women do," she said. "I see what the other people in this training course have done, and it has shown me that it's possible for me, too. I'm an open book. If I can help anyone else who has gone through something like this, then I will. I would never have signed up for [losing my leg]. But it happened, and I choose to make the best of it." Previous articleGuyer could not get by Westlake in state title rematch Next articleArgyle police recognize father, son who helped save girl Steve Gamel

Once I'd finished sewing my Janet costume I knew that I also wanted to carry a cactus. Not just any cactus, though– a cactus-shaped purse. Stylish *and* practical! I started off with a plastic 5″ pot to form the base of the purse. It was actually hard to find– usual sizes are 4″ (much too small) and 6″ (too big)– but I needed that size because I wanted to be able to fit my phone and a few other bits and pieces inside, but didn't want it to be too bulky. Janet (The Good Place) Costume, Part IV: Done! Fun fact: Janet is me! What do you think? I kind of love it. Caveats: I still can't get the lighting right, the hair needs a little work, and the gigantic smile (yet without crazy-eyes) still eludes me. Oh well, some other time! Sorry for the delay in posting about this costume– I was waiting for a zipper to arrive, and then it turned out to be out of stock (thanks a lot, FashionFabricsClub.com, for making me wait three weeks without bothering to tell me you didn't have my order), and I had to order it from Amazon. Anyway, Janet's skirt is a bit more flared than a standard A-line, but doesn't have the fullness through the hip of a circle skirt. The panels (I think there are nine, since there's no center front seam) are actually fitted through the hip and then flare out from just below the hipline. To draft my pattern I took my waist measurement and my hip measurement (8″ down from the waist), and divided by nine to get the fitted top part of the skirt. From the hip point I continued drawing the lines along the same angle just for reference, extending them down to the hem (the panel was a total of 25″ long). Once I determined where the original lines would be, I extended the width of the panel by 3″ at the hem (total, so 1.5″ on each side) to get that extra flare. Now that the outfit is done, I figured I could take some time to provide resources for any other would-be Eliza Doolittles! I will note that I wasn't able to make my dress exactly screen-accurate– I didn't locate all of my reference images until I'd already done some of the work, and it wasn't worth it to me to re-do things like the embroidery on the center skirt panel to get it exactly right. I did, however, try to reproduce the original as best I could under the circumstances. For what it's worth, the dress has about 7,000 individually-applied sequins and rhinestones, so you'd better be up for a lot of handwork! 2 yards each of 2.9cm and 3.2cm round floral trim to make round appliques. Definitely use blunt-needle syringes as applicators for the sequins and rhinestones. Once they're full of glue you can store them point-down with the needle tips in a mug with about an inch or water in the bottom, and they'll stay usable almost indefinitely. The water keeps the glue from drying inside the needle section, though Gem-Tac does occasionally get clumpy so I can't promise you won't need to occasionally swear a little as you un-clog the needle by soaking it in hot water. I worked with two syringes at once so I'd be sure to have a working one at all times. Toothpicks (the blunt ends) were perfectly good tools for picking up sequins and the tiny rhinestones. I wouldn't bother with Q-tips or the special wax sticks you can find online. If you can't find perfect appliques, don't be afraid to cut apart/combine other appliques to get the effect you're going for. Particularly since this gown has so much sparkle on it, no one will be looking closely enough at the precise type of lace you're using to see if it matches everywhere. While it might seem easier to do the embellishment on the overgown before attaching it to the undergown, I think that it's necessary to have the whole thing hanging on a dress form before you finalize the placement of the swags and appliques. Otherwise you might end up placing something incorrectly and not finding out until it's too late to fix. Don't finalize any embellishments at the hem until you've tried on the mostly-embellished gown and ensured that the net hasn't stretched out. Don't store the dress on a hanger or dress form– keep it flat to avoid further stretching. It may also be a good idea to leave the bottom few inches relatively plain in case you need to hem it again later and don't want to lose detail. And of course, if anyone needs help with laying out embellishments or figuring out how best to drape the dress, feel free to comment on this post and I'll try to respond! Good luck!

HomeAwardSpecial Awards by HIPA to Tim Flach, Tom Ang, Yousef Al Habshi Special Awards by HIPA to Tim Flach, Tom Ang, Yousef Al Habshi 11 March 2019 Award, Photography 0 The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) has announced the 'special award' recipients for its eighth season of competition. These go to "photographers that have contributed positively to photography as an art-form and industry" and for this season HIPA has named recipients of the 'Photography Content Creator Award', the 'Emerging Person in Photography Award' and the 'Photography Appreciation Award'. The latter goes to British photographer Tim Flach, for his outstanding contribution to photography in the fields of nature and the environment throughout his career. The image at the top, Red Crown Cranes Dancing, is from his brillaint Endagered series. Tim Flach has become one of the most influential animal photographers in the world, seeking to use photography to shift public and scientific perceptions of the natural world with imagery that evokes powerful emotional responses – his core belief is that widespread emotional response leads to direct action. He said he felt it a great honour to be on the list of distinguished personalities honoured with the award. "At this point in history we are growing further away from the world of nature while we are increasingly in need of it, in terms of food, climate and other important issues. Many in our world still do not realise the gravity of the challenges that require us to protect nature more. As images are one of the best and most effective methods of human communication in this age, I seek to move people's feelings and raise their awareness through the stories I tell them through images." New Zealander Tom Ang received the Photography Content Creator Award for his educational work – he has authored more than 40 books on photography, among them the best-selling Digital Photographer's Handbook and Digital Photography Masterclass. He has also written and presented TV series, held editorial posts at and been a correspondent for numerous photography magazines, has taught photography, photojournalism and publishing at BA and MA level for over 12 years, and has been a consultant to the photography industry for many years. The Emerging Person in Photography Award was given to Emirati photographer Yousef Al Habshi, noted for his macro and micro photography as highlighted in National Geographic magazine. Al Habshi's competition achievements include two consecutive first places (2012 and 2013) at the Emirates International Photography Contest, and another first in the Nikon Small Worlds micro-photography competition. Al Habshi was fulsome in his praise for HIPA: "I cannot imagine the magnitude and responsibility that HIPA have year-on-year ensuring that the spotlight on photography continues to shine bright. HIPA is paving the way for all genres of photography, as well as raising awareness of emerging ones. Their support of photography in the scientific field is both encouraging and motivating. HIPA continues to prove to us year after year that it strives to present new, different and contemporary aspects of photography." HIPA's main awards – with the largest monetary prize among photography awards, totalling $423,000 this year – are due to be announced this weekend. We'll report next week. DIDI and Dubai Holding hunt for design ideas from UAE school students The big one is back: Art Dubai is fuller, leaner and better organised

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I had a beer tonight with David Brown, and much to my surprise he whipped out this old email that he recently stumbled across. This email is the birth of Techstars. To give you a little context, Boomtown Enterprises was the name of a small investment fund that David and I operated at the time. I edited the original email very lightly to fix one typo and in one case to protect the identity of the innocent. I'm just thinking this can be one of the boomtown businesses. Providing seed capital to startups with only an idea. 2) We fly or drive to interview the ones that sound good (perhaps organizing small tours), or have them come here on our dime. 3) We offer the promising ones $10k for a 2% non-controlling, non-board seat interest of their company. They have to come to Boulder for 2-3 months to start the company up. a. They can work in our offices, or in a hotel, or wherever they want. We provide internet connections, a little office space, etc. b. They can use the 10k however they want. c. We have the option to buy 2% more of the company for another 10k at the end of the 2-3 month period. d. We provide free consulting while they're here including product feedback, how-to advice, etc. e. We organize weekly (or bi-weekly) dinners with investors, IP lawyers, tech experts, etc (basically using our contacts to get people to donate a little time). 5) If they want, they can stay in Boulder and grow their company here, working within our office space (renting it). Perhaps we have some kind of "space, connectivity + consulting" lease rate. The only drawback I can think of is that we'd probably need to get a slightly nicer office to really attract companies. We'd have to look successful, and have an environment with couches, whiteboards, etc for them to work in optionally. But we could grow that over time once we get a few and have a good feeling that it's working. I am thinking I'll start working on the web site. Are you cool with putting this kind of info/offer up on the boomtown site? We don't have to actually do it, I suppose, but we can at least start taking applications and see what's what. Maybe generate a little word of mouth somehow, and who knows. We can start with a summer program this year. Sublet or rent some open office space from this place for just 3 months or something. Start trying to spread the word a little bit on college campuses, especially CU, CSU, DU, etc. Thoughts? I think it sounds really cool. Yeah, we have no idea what we're doing. So that's how we came up with this crazy idea just 868 days ago. I remember putting up the basic web site later that same day. Obviously, it has evolved since then. Now we have some sense of what we're doing, for example. We didn't launch Techstars that summer – it just wasn't enough time to raise the necessary funding and morph the idea into what would ultimately make it successful – being mentorship driven. But we got there the next summer, and we've been learning and evolving ever since.

During my early years much like everyone else, I enjoyed a good, lets get legless drinking game now and again. Me too! Funny! Ask The Admin: The Ultimate Guide to Being Married to a Nerd! Understand your nerd's relation to the computer. It's clichéd, but a nerd is defined by his computer, and you need to understand why. "Based on the idea of mailing Flat Stanley off to California, we thought it would be fun to see how many places our Flat Stanley could visit between now and the end of the school year" So cool! Social networking and Web 2.0 meet kids education! Thanks for the link to my wife's blog and her entry on our experiment with Flat Stanley!

Cenzo Townshend Decoy Studios It's a hit! Openreach makes full fibre available to 100,000 local premises More than 100,000 homes and businesses across Suffolk can now order Ultrafast Full Fibre, thanks to a £30 million broadband investment by Openreach. And the work has already hit the right notes for a leading music studio near Woodbridge, where they're discovering that reliability is key, and their broadband speeds have reached the top of the charts, after engineers were instrumental in connecting them. Award-winning music producer Cenzo Townshend from Decoy Studios, based in the small village of Melton, had approached Openreach for help as they were struggling with slow speeds. Decoy works with world famous artists including Sam Smith, Ed Sheeran, Lewis Capaldi, Snow Patrol, and The Maccabees. They regularly transfer large music files between their studios in rural Suffolk, to places like London and Los Angeles. But things were so bad they could only upload and download recordings overnight, putting them at a significant disadvantage compared to rival studios. It led to fears they would struggle to attract stars who value the peace and tranquillity of the Suffolk countryside when they're penning their new album or recording their latest single. Thankfully Openreach's Chief Engineer team stepped in and blitzed the build in just a few days, with Decoy Studios and surrounding homes upgraded to a new ultrafast, ultra-reliable full fibre network, which is future-proof for decades to come. Some of the fastest broadband speeds in the UK are now available there, securing the long-term future of the business. Cenzo Townshend says the arrival of full fibre is a huge boost: "We were really starting to feel the impact of a slow broadband connection. Having a studio outside of London brings many advantages to us, but we need to have a similar level of connectivity so we can communicate between studios, and with artists. "We must download 30 to 40 Gigabytes at a time, and we upload double that sometimes. Slow speeds were a big problem for our business. It came to a head when we were trying to finish a very important album, which involved large music files being bounced around between Suffolk, London, and LA. It got to the point when we just couldn't upload what we needed to. Speeds of less than 10Mbps on average were just not cutting it, so we knew we had to do something. "Since we started work with Openreach's Chief Engineers team, things have moved quickly, and we've now got full fibre up and running. They were determined to make sure we had the best connection possible and pulled out all the stops to make it happen. We can now easily transfer music and have 2 or 3 artists recording at the same time and it has no impact on how our broadband performs." If Openreach's full fibre build was measured in record sales, it would be closing in on Platinum status, having already reached around 800,000 homes and businesses across the East of England, including more than 100,000 in Suffolk. Work is currently underway in Ipswich (Kesgrave and Foxhall), Lowestoft, Stowmarket, Sudbury and nearby Woodbridge, where it was announced in May that around 5,000 local homes and businesses would be the next to benefit from Openreach's full fibre build. Director for Openreach's Chief Engineer team in East Anglia, Phil Royal, said: "Bringing full fibre to Decoy Studios and the surrounding homes was quite a challenge but one that my engineers tackled with huge determination. We needed to use a mix of infrastructure – some of it underground - and think creatively when working out how to get fibre across the Suffolk countryside to Melton, from the nearby exchange in Woodbridge." "To minimise disruption, we used existing parts of the Openreach network wherever possible. This is not only easier for us, but it keeps things like digging up roads, using temporary traffic lights and moving big heavy equipment down local country roads to a minimum. We know these are the issues that are important to people living in rural areas. "It's not every day you get to work in and around a music recording studio that has famous artists popping in and out and we're delighted to have made a difference in this community. Cenzo and his team at the studio couldn't have been more helpful, accommodating, and welcoming, and we're grateful for his support during the build." Full fibre broadband offers download speeds of one gigabit per second (1Gbps), which means it's up to 16 times faster than the average home broadband connection. This means faster game downloads, better quality video calls and higher resolution movie streaming are possible. It's also less affected by peak time congestion and it allows people to use multiple devices at once without the connection slowing down. That means more people can get online at the same time without experiencing stuttering, buffering or dropouts. Openreach's role across East Anglia and the East of England extends beyond making full fibre broadband available. The company has roots in almost every community, with more than 3,500 Openreach people living and working across the region. £180m broadband network reaches 600,000 across Wales

Originally the term stationery referred to all products sold by a stationer, whose name indicated that his book shop was on a fixed spot, usually near a university, and permanent, while medieval trading was mainly carried on by itinerant peddlers (including chapmen, who sold books) and others (such as farmers and craftsmen) at markets and fairs. It was a special term used between the 13th and 15th centuries in the manuscript culture. The Stationers' Company formerly held a monopoly over the publishing industry in England and was responsible for copyright regulations. In its modern sense including personal writing materials, stationery has been an important part of good social etiquette, particularly since the Victorian era. Some uses of stationery, such as sending a manufactured reply card to a wedding invitation, have changed from offensive to appropriate. The use and marketing of stationery is being partly superseded by electronic media. Stationery is intrinsically linked to paper and the process of written, personalized communication, and many techniques of stationery manufacture are employed, of varying desirability and expense. The most familiar of these techniques are letterpress printing, embossing, engraving and thermographic printing (often confused with thermography). Flat printing and offset printing are regularly used, particularly for low-cost or informal needs. dtbaker is the combined efforts of two freelance web developers. Hayley (design) & Dave (code). We have been working together since 2005.

Scottish Quality Crops maintains farm and quality assurance standards for growers throughout Scotland. Scotland has taken the lead in the development of farm and quality assurance schemes. With several mechanisms now in place Scottish Quality Crops work closely with the farmer to firmly place Scotland's combinable crops at the premium end of the UK and European markets. Through farm assurance, Scottish combinable crop growers - in association with their trade partners - are responding positively to increasing consumer awareness about modern food production. With the Food Safety Act 1990 placing an onus on every sector of the food chain, from production through to consumption, SQC has adopted a whole industry approach representing all sectors of the combinable crop growing, wholesaling and processing industries.

Sussex County rape suspect sought Police provided no details of the alleged rape. Sussex County rape suspect sought Police provided no details of the alleged rape. Check out this story on delawareonline.com: http://delonline.us/1qqlO2U robin brown, The News Journal Published 7:03 p.m. ET Nov. 5, 2014 | Updated 12:35 a.m. ET Nov. 6, 2014 Randy D. Boulden (Photo: Courtesy Milford police ) Police asked Wednesday for public tips to find Randy D. Bolden, who they say is a suspect in a Sussex County rape case. Bolden, whose age and address were not released, is wanted on various court warrants and in the rape case by the Milford Police Department, spokesman Detective Dwight Young said. Bolden now may be in the Milton area, Young said. Bolden also is known to frequent the Laurel, Milford, Seaford, Dover and Lincoln areas, as well as different parts of Maryland, he said. Police said he is 6 feet tall and weighs 200 pounds. Those with tips are asked to call their local police department or Detectives Young and John Horsman at (302) 422-8081. Information also may be given to Delaware Crime Stoppers at (800) TIP-3333 and www.tipsubmit.com. Contact robin brown at (302) 324-2856 or [email protected]. Find her on Facebook and follow her on Twitter @rbrowndelaware. Read or Share this story: http://delonline.us/1qqlO2U

Facebook • 16 Aug 2021 Facebook adds end-to-end encryption to voice and video calls on Messenger By Sam Spiller, Staff Writer Read nextThe top Google searches in South Africa over the last 15 years Facebook has announced it has added end-to-end encryption to voice and video calls on its Messenger app, as well as new controls for disappearing messages. The social media giant announced the security feature on 13 August. "People expect their messaging apps to be secure and private, and with these new features, we're giving them more control over how private they want their calls and chats to be," Director of Product Management for Messenger, Ruth Kricheli, wrote in a blog post. What does end-to-end encryption do in Messenger? End-to-end encryption means that messages and communication are only viewable by the recipient and sender. With the encryption, Facebook cannot read, listen, or see what app users send each other. However, users can still report messages to Facebook even if they are encrypted. At the same time, Facebook has updated the options for its disappearing chat message feature. Users now have more options regarding the amount of time a message will hang around before it disappears. They can choose periods from as short as five seconds to as long as 24 hours. According to Facebook, voice and video calls have experienced a surge in popularity during the past year. Users make more than 150 million video calls a day using the app. Meanwhile, Facebook revealed it will test several other encryption features for its collection of apps in the coming weeks. It will test end-to-end encrypted group chats and calls in Messenger. It will also test opt-in end-to-end encryption for Direct Messages (DMs) on Instagram. Featured image: Facebook Read more: Telegram adds new video features, calls of up to 1000 viewers Sam Spiller, Staff Writer Sam is a writer for Burn Media. He has walked a mile in technology and entertainment journalism, previously working for Popular Mechanics SA and the Weekend Argus. When he's not writing, he can be found playing Overwatch or driving up the coast. Posted in Facebook, Programs & Apps, Social, Social networkingTagged End-to-end encryption, Facebook, facebook messenger, Facebook Security, Instant Messaging, messenger, Messenger app, security feature, Video calls, Voice calls The top Google searches in South Africa over the last 15 years Google • 16 Aug 2021

Home Fact Check Trump & his choir keep lying about Mueller report Trump & his choir keep lying about Mueller report Allegations of "collusion" were not "proven false" in the Mueller investigation, nor was the issue of "collusion" addressed in the report. HOPE YEN Attorney General William Barr testifies during a Senate Judiciary Committee hearing on Capitol Hill in Washington, Wednesday, May 1, 2019, on the Mueller Report. (AP Photo/Andrew Harnik) President Donald Trump and his team are still twisting the findings of the special counsel's report on the Russia investigation. At a Senate hearing Wednesday, Attorney General William Barr echoed Trump's refrain of "no collusion" between the Trump campaign and Russia, insisting that any and all allegations of collusion have been "proven false." That's not the case. Senate Judiciary Committee Chairman Lindsey Graham also got it wrong when he asserted that special counsel Robert Mueller had asked Barr to make a ruling on whether Trump obstructed justice. A look at the claims: TRUMP: "NO COLLUSION, NO OBSTRUCTION." — tweet Wednesday. BARR: "The evidence is now that the president was falsely accused of colluding with the Russians and accused of being treasonous. …Two years of his administration have been dominated by allegations that have now been proven false." — Senate hearing Wednesday. GRAHAM, Republican senator from South Carolina: "Mr. Mueller and his team concluded there was no collusion." — Senate hearing. THE FACTS: Allegations of "collusion" were not "proven false" in the Mueller investigation, nor was the issue of "collusion" addressed in the report. The Mueller report said the investigation did not find a criminal conspiracy between the Trump campaign and Russia, saying it had not collected sufficient evidence "to establish" or sustain criminal charges. The report noted that some Trump campaign officials had declined to testify under the 5th Amendment or had provided false or incomplete testimony, making it difficult to get a complete picture of what happened during the 2016 campaign. The special counsel wrote that he "cannot rule out the possibility" that unavailable information could have cast a different light on the investigation's findings. The report also makes clear the investigation did not assess whether "collusion" occurred because it is not a legal term. The investigation found multiple contacts between the Trump campaign and Russia, and the report said it established that "the Russian government perceived it would benefit from a Trump presidency and worked to secure that outcome, and that the Campaign expected it would benefit electorally from information stolen and released through Russian efforts." GRAHAM: "As to obstruction of justice, Mr. Mueller left it to Mr. Barr to decide after two years, and all this time. He said, 'Mr. Barr, you decide.' Mr. Barr did." — Senate hearing. THE FACTS: Not true. Mueller did not ask Barr to rule on whether Trump's efforts to undermine the special counsel's Russia investigation had obstructed justice. According to the report, Mueller's team declined to make a prosecutorial judgment on whether to charge partly because of a Justice Department legal opinion that said sitting presidents shouldn't be indicted. As a result, the report factually laid out instances in which Trump might have obstructed justice, specifically leaving it open for Congress to take up the matter or for prosecutors to do so once Trump leaves office. Barr wrote in a March 24 letter that ultimately he decided as attorney general that the evidence developed by Mueller was "not sufficient" to establish, for the purposes of prosecution, that Trump committed obstruction of justice. Barr subsequently acknowledged that he had not talked directly to Mueller about making that ruling and did not know if Mueller agreed with him. Find AP Fact Checks at http://apne.ws/2kbx8bd Follow @APFactCheck on Twitter: https://twitter.com/APFactCheck.

Lira rises against pound, loses against dollar ISTANBUL Economy Following Britain's decision to withdraw from the European Union, the value of the Turkish lira has risen and enabled local investors to derive profits from sales, and has pushed the dollar to TL 2.9085. With the announcement of the Brexit referendum results, the value of the dollar has rose above 3.00 and reached a balance at 2.93 on Friday afternoon. Also, the value of the British pound in relation to the lira has dropped to its lowest level since April last year. Britain's historic vote on secession from the EU has both dragged the country's future into uncertainty and dealt a heavy blow to the integrative efforts of the EU, which has aimed to form a more unified Europe since World War II. Global financial markets have plunged as referendum results showed 51.8 percent of the British people voted to exit the union, while the remaining 48.2 percent voted to remain in it. After the dollar-lira parity surged to 3.0015 from 2.8731/2.8754 on Thursday evening, it finally dropped below 2.92. The parity last experienced the same high level on May 24. Currently, as of press time, it is hovering above 2.92. The pound-lira parity, which reached 4.2419 at the end of Thursday, has dropped down to its lowest level, 3.9205, since April 14, 2015. Speaking to NTV, HSBC Portfolio Strategist İbrahim Aksoy said global central banks might display a coordinated action in the upcoming period in the wake of the referendum, adding that for a while, markets will not ask when the U.S. Federal Reserve (Fed) will hike interest rates. Aksoy also noted expectations that the post-Brexit period will experience abundance in global liquidity, which might create a positive atm osphere in the markets after a while, continuing, "This is not yet the case, but it will happen after sales continue for a bit more." Referring to the fact that the lira has lost 2.2 percent of its value against the currency basket and the five-year Credit Default Swap (CDS) has increased, Aksoy said, "Interest rate cuts launched over the past four months and the residents' decline of foreign exchange deposits by $8 billion, which has left no supportive space for the lira, indicates that the dollar might exceed the 3.014 level that it experienced on May 24." According to Aksoy, the decline in the U.S.'s bond yields might restrict the upward impact on lira-denominated bond yields to a certain extent. With the decrease in global risk appetite, the 10-year bond yields, which stood at 9.45 percent at the end of Thursday, might approach 10 percent today.

Home > Magazin > Interviews > Prof. Dr. Stefan Pützenbacher High-rise Master Plans and Urban Developments in Frankfurt A Conversation with Real Estate Expert Prof. Dr. Pützenbacher The high-rise framework plans in Frankfurt are supposed to regulate the locations at which new high-rise buildings from 60 meters (197 feet) in height may be built. The readers of SKYLINE ATLAS submitted interview questions for the interview in May 2019. Now the renowned construction expert Prof. Dr. Pützenbacher answers to less publicly known details about the development of new high-rise locations. "There must be no thinking bans on the development of high-rise buildings outside of the previous locations." — Prof. Dr. Pützenbacher SKYLINE ATLAS: Good morning, Professor Pützenbacher. Nice that you found time for our interview. What is it that fascinates you personally about Frankfurt and real estate? Prof. Dr. Stefan Pützenbacher: For me, the diversity of architecture and real estate in Frankfurt is very memorable. If you drive into the city on the motorway in the morning, depending on which route you choose, you can see the skyline from different perspectives very early. For me it is very impressive to see the skyline and follow its development. What fascinates me is the movement, the constant change. It is a constant process that is not static, and of course I also contribute creatively as part of my legal advisory work as a lawyer. SKYLINE ATLAS: How did you come up with the subject of real estate law and what led you to become a legal expert on skyscraper master plans? Prof. Dr. Stefan Pützenbacher: I was interested in real estate law because sooner or later you can see the results of your work when advising on real estate law. In contrast to legal departments, which are more in the banking or corporate area, real estate law is mainly characterized by the fact that the advice bears recognizable fruit. In other words, if you give advice on high-rise planning and the high-rise is up and running four or five years later, then that's something I really like to tell my children because I've been accompanying the processes behind it for years. SKYLINE ATLAS: Let's talk about investors and the administration. You have been dealing with real estate law since 1997. According to your subjective perception, what has changed in the last 20 years or so? Prof. Dr. Stefan Pützenbacher: It has changed that cities and municipalities no longer have an open ear for every investor project. Instead, the cities are trying to steer the development – especially of high-rise buildings – in an orderly manner. That was different in the 1970s and 1980s. In the 1970s and 1980s, the city of Frankfurt in particular welcomed every investor with a kiss and somehow made the high-rise project possible for them, possibly even at the limit of legal admissibility, as we now know from court decisions. Today it is different. One tries to bring more structure into this topic through the high-rise master plan. This annoys investors, but it opens up very good development opportunities for those properties that are already shown in the high-rise master plan. SKYLINE ATLAS: Do neighbors from a high-rise location have the opportunity to object to the construction? Prof. Dr. Stefan Pützenbacher: Basically, neighbors of building projects have the right to invoke rules and regulations that protect their neighbors. Purely in terms of planning law, these are, for example, the stipulations on the type of structural use that give the neighbor a so-called area conservation claim. Purely in terms of building regulations, these are, for example, spacing area issues, i.e. the question of whether or not the limit distances specified in the Hessian building regulations / state building regulations are observed. In the case of all neighboring building projects, the client can be countered with the fact that he does not comply with the building planning law requirement of consideration if a building project affects the neighborhood in such a significant way that this can no longer be expected of the neighbor from the point of view of a neighborly community relationship. However, the case law has set a very high hurdle for such objections. According to this stipulation, only measures that "shield" the neighbor, put him to an urban isolation, or that have an "overwhelming effect" on the neighbor or the buildings on the neighboring property are grossly inconsiderate. However, this will only be the case if a high-rise building has a particularly strong impact on a neighboring property that is significantly less developed. The deprivation of sun and ventilation, which would then have to have measurable effects on the quality of living and working on the neighboring property, would be such a circumstance that is grossly inconsiderate. However, this is regularly checked by experts during high-rise project development. The neighboring issues are then often dealt with by what are known as neighboring agreements before the construction work begins. SKYLINE ATLAS: How can a client bring a completely new high-rise project to the city for discussion? Prof. Dr. Stefan Pützenbacher: Every building owner is entitled to have the building feasibility of his property checked by the town planning office/the building supervision as part of a preliminary building inquiry. However, if the city has declared within the framework of the high-rise master plan that it will only allow new high-rise locations if they are already shown in the high-rise master plan, it is very difficult for a client in practice to build on a project that is not included in it. The high-rise master plan allows exceptions to the principle contained therein and grants builders with a special position or public importance (such as the European Central Bank) the right to be able to build high-rise buildings even on properties that are not shown in the high-rise master plan. Experience has shown that the city is very cautious about this exception. SKYLINE ATLAS: As an interested citizen, can you participate in the high-rise master plan? Prof. Dr. Stefan Pützenbacher: The preparation of masterplans and urban planning framework plans is fundamentally an internal administrative matter, as these plans do not have any direct impact on the rights of property owners and citizens. Therefore, the possibilities for participation are fundamentally limited, unlike, for example, opportunities to participate in the preparation of a development plan. However, it can be assumed that the city will set up workshops as part of the process for the renewal of the high-rise master plan, which are open to the general public in addition to the experts represented therein. After all, the city is about planning for its citizens, so that citizens' interest in new high-rise locations must also play a role. SKYLINE ATLAS: Which topics are negotiable between the client and the City of Frankfurt? Prof. Dr. Stefan Pützenbacher: In real estate practice, it happens again and again that lengthy negotiations are conducted between building owners and the city about the use of a property. The main topics are the height of the building or the utilization figures (GFZ and GRZ), which are defined in the development plans. However, topics such as follow-up infrastructure measures, i.e. the question of whether the builder has to pay for traffic lights, pedestrian crossings, daycare places or a measure to improve the general environment, are the subject of negotiations with the city. Recently, the "housing compensation" requested by the city has been the subject of negotiations between the building owner and the city again and again. This is about the question of whether a 30 percent share of residential property must be proven when realizing high-rise buildings in the building or elsewhere, and the resulting additional question of whether an approximately 30 percent share should also be included in the case of the creation of living space socially supported living space must be created. Since both demands of the city fundamentally frighten the office tower investor, the negotiations are conducted very intensively and often sealed with a regulation in an urban development contract. SKYLINE ATLAS: How long does a new high-rise project, once approved, remain valid? Prof. Dr. Stefan Pützenbacher: In principle, the building owner can claim the legal protection you are referring to for three years from a building permit, i.e. H. as long as he can use a building permit for a high-rise building that has been granted. If the building permit has not yet been granted, but a high-rise project has only been determined by planning, a building permit for a high-rise building based on this plan can be applied for as long as the plan remains unchanged. In the case of approved high-rise buildings, the builder can also defend himself against subsequent changes to technical or legal standards in the building permit by way of inventory protection, for example in the event of specific dangers, for example, retrofit fire protection or static precautions. SKYLINE ATLAS: Do city councilors have to approve each high-rise project individually? Prof. Dr. Stefan Pützenbacher: Since the decisions of the Administrative Court in Frankfurt and the Hessian Administrative Court on the Eschersheimer Landstrasse 14 project, it has been made clear by the court that every high-rise project requires a "tailor-made development plan" because of its diverse effects on the surroundings and the cityscape. According to the regulations of the Building Code, a development plan is drawn up as a municipal statute. Various resolutions in the city council are required for this. As a result, the city councilors have to deal in detail with every high-rise project that requires a development plan. SKYLINE ATLAS: Can an investor implement a completely new high-rise location? SKYLINE ATLAS: What things should be simplified or improved regarding real estate law or building? Prof. Dr. Stefan Pützenbacher: Well, we have already seen numerous changes to the law and amendments in recent years, most recently in 2018 in the Hessian building code. Above all, the transfer of responsibility for a large number of structural and technical requirements to the client is a very, very important point. This means that as an investor or building owner you can no longer be sure that once a permit has been issued by the city, all points will be checked and "stamped". I actually think that's a very good form of deregulation. On the other hand, of course, it means for the building owner that he has to protect himself when planning building projects. Securing means concluding contracts and concluding contracts usually means taking a lot of money in hand. SKYLINE ATLAS: What are your very personal wishes for the future of Frankfurt? Prof. Dr. Stefan Pützenbacher: I would like the city to develop further in terms of high-rise planning and that the realization of high-rise buildings does not turn into a kind of "closed shop" at some point where people say, "We have now reached a point where things cannot go on." I am of the opinion that urban development is a dynamic process and that it must not be brought to an end through early planning. There must be no thinking bans on the development of high-rise buildings outside of the previous locations and therefore I would like to see dynamic development continue. SKYLINE ATLAS: Let's move on to the last question. What is your personal opinion on the high-rise master plan? Is that a good thing, is it too stringent or does it not go far enough? Prof. Dr. Stefan Pützenbacher: I think the master plans are basically a good thing, because there shouldn't be any uncoordinated high-rise distribution. Therefore, a rough framework plan with preliminary decisions about high-rise clusters and individual high-rise locations makes sense. The crucial question, of course, is how strictly the high-rise master plan is lived. If it means the general end for alternative high-rise locations per se, then I think it can be criticized on this point. SKYLINE ATLAS: Thank you for the conversation. The interview was conducted in July 2019. About the Person Prof. Dr. Stefan Pützenbacher is a lawyer and notary, specialist lawyer for administrative law, honorary professor for planning and construction law and member of the Frankfurt Research Institute for Architecture • Civil Engineering • Geomatics at the Frankfurt University of Applied Sciences (FFin). He is still known from publications in the relevant specialist media. His contributions can also be found in numerous books. About the Frankfurt Research Institute for Architecture • Civil Engineering • Geomatics (FFin) The FFin stands for research competence in planning, construction and operation in the Frankfurt Rhine-Main urban area. With its planning and construction-related disciplines, the FFin shows a special social responsibility for sustainable development and the well-being of people in urban and rural areas. Application-oriented research provides results for resource-saving planning and development as well as an aesthetically pleasing design of the built environment. More than fifty scientists from various disciplines are currently researching "real estate" at the FFin. Research on high-rise topics is often in the foreground. Further information about the Frankfurt Research Institute for Architecture • Civil Engineering • Geomatics (FFin) is available on the FFin website: www.ffin.eu The recipients of the SKYLINE NEWS had access to this content earlier than any other reader. Practical implementation of the goals of the high-rise plan (soon) High-rise development plan 2021 Questions and answers about the Frankfurt skyline Around ten new high-rise buildings are built in Frankfurt every year. Prof. Dr. Stefan Pützenbacher High-Rise Development Plan 2021: Three High-Rise Clusters… André Friedel Interview with Prof. Jochem Jourdan Interview with Prof. Fabian Thiel Deutsche Bundesbank Campus: Architect Competition Decided

The Solo manual, with original piston rails and slip removed. One of our most recent projects is the refurbishment of the manual keyboards on the magnificent four-manual Pilcher at the WWI Memorial Auditorium here in Louisville. We have been involved with the instrument nearly two years, and are making a significant push to get the instrument, now five years after being silenced to rebuild the console and switching relay, into suitable shape for giving concerts again by the Fall of this year. Though the stop actions and combination actions were rebuilt, the manual claviers were left in their original condition. This left the key tension with no adjustment (since the leather-nuts were popping off when touched). The original thumb pistons were also refurbished. Though this effort of the organ's previous caretaker was heroic, it turned out that the use of the original hardware was problematic when used in conjunction with the modern solid-state relay. We were faced with having to advise the client (in this case, the William H. Bauer Foundation, the non-profit organization who oversees and funds the organ restoration) as to a proper course of action. In this position, we have always concurred that the best course of action for this landmark, historic instrument is to leave things in as original condition as possible, using original methods and materials. Of course, the Foundation had wisely opted, when the unwieldy pneumatic relay was failing, to replace it with a modern relay, which returned the instrument to reliable, functional condition, especially in a setting where there is little chance for regular service. It was with this in mind that we advised to procure modern thumb-pistons, with reed-switch action. Philosophically speaking, when dealing with an historic instrument of note, we feel it is important to be conscientious towards the original conceptions and intentions of the original builder. As we charge full speed through the twenty-first century, we see that many of the magnificent instruments of the former two centuries have been either dismantled or fundamentally altered to reflect changing tastes. It is becoming much more rare to see instruments from these exciting periods in their original conceptions. Though the world moves onward, these instruments serve as time-capsules for a former day, often shedding light on perspectives of our trade that we have overlooked in the modern musical milieu. Those perspectives may not reflect our own, but they were important enough to our ancestors to go through the great trouble of putting them into production, laboring intensely for years (as pipe organs are still consigned to be produced) to accomplish their construction. Do we not owe it to the memory of these folks to give their conceptions respectful consideration when we are called upon to render them service? On the other hand, this need not be carried out to an extreme. An instrument must first serve the purpose for which it was intended, and if this purpose is not being served due to some defect, a conscientious remediation must be considered. For example, the organs of the 1920's, such as the very one at the WWI Memorial Auditorium, were run through very complicated and intricate electro-pneumatic relays, which are very difficult to repair and expensive to rebuild. Except in a few extreme cases, these units are rightfully replaced with modern solid-state relays, which are simple in conception, easy to service, and are more reliable over time. Of course, there is much gray area involved, and often it is not clear whether making a change to a particular part or system will affect the historical value of the instrument as a whole. One must consider the instrument holistically, and any proposed changes should be looked at in light of the principles articulated above. The Organ Historical Society has taken great strides in educating the general public about the proper methods of preserving an instrument, and their guidelines should be consulted, both by any builder in question and also by the owners of the instrument themselves. It was according to this line of thought that we have proceeded with the Auditorium instrument manual rebuild. Restoration of the manuals themselves is rather simple, as the keytops are in marvelous shape already and merely need a good cleaning and new leather nuts. The thumb pistons will be replaced, as we already mentioned, with Syndyne reed-switch units. Reed switches, sealed in a vacuum and activated by a magnet, do not corrode or "drag" like the original exposed contacts, which causes unreliable action. We have worked with Syndyne's on-staff engravers to choose a font which reflects the particular type already represented by the old pistons. Since new rails will be made up, we will alter the layout to include functions not available in the original combination action, such as sequencing, increased number of general pistons, and pistons that work some of the traps. The original units will be well preserved inside the organ for future reference and documentation. The original divisional name plates will be retained. Progress of the manual rebuild and of the rebuild of the organ in general can be seen from the "World's Largest Pilcher" Facebook page.

The Failure of Liberal Feminism in the Trump Era Post on: February 6, 2017 Celeste Murillo The restrictions imposed by the new administration on the right to choose and the promise of new attacks raise the question of how to defend women's rights in the Trump era. One of Trump's first executive orders prohibits the granting of federal US funds to organizations that perform abortions or provide abortion-related counseling abroad. This measure was widely condemned in the United States and worldwide. The Dutch government countered by proposing to establish a global fund to finance programs in so-called "developing countries" to support sex education and the right to choose. The measure may be a temporary palliative measure. However, it is not a solution to the fundamental issue, which is that the rights we have gained could be taken away from us with the stroke of a pen if they are not defended by protests and a constant struggle to guarantee that everyone – not just small sectors of society – can exercise them. Women's rights in the United States are at serious risk. Trump's administration has already ordered the defunding of organizations that support women's right to choose, his Vice President led the anti-abortion march and the Republican majority in the House of Representatives voted against funding Planned Parenthood . But that's not all. Women's rights are at risk because the Democrats, who governed the country for 8 years under Obama, a self-proclaimed feminist, did nothing to stop the Right's offensive. In several states, laws were voted to restrict the right to abortion, particularly affecting women relying on State health programs. Trump has also nominated a pro-life judge to the Supreme Court. This opens the door to the possibility of a historic rollback of the Roe v. Wade ruling. The very possibility of this happening is – to a great extent – attributable to the Democratic Party and the feminist movement who have not put up a fight against attacks to the right to chose. The Neoliberal Trap The situation we find ourselves in is the result of the strategy of congressional pressure and compromises of most of the feminist movement in the United States, which went from taking the streets to depending on government agencies, and from acritique of patriarchy to watered-down "inclusive agendas." Limited representation in positions of power created a facade of inclusion that masks the economic exploitation of working class women, where LGBT, African-Americans and Latinos are overrepresented. The fatal trap of inclusion led George W. Bush, for example, to use women's rights to justify the invasion of Afghanistan in 2001- using decontextualized women and human rights violations as a justification to invade and bomb- a racist colonial maneuver that in fact increases violence against the very same women. In this and other neoliberal causes, feminism has played a role in justifying reactionary policies, entangled in a "dangerous liaison" with capitalist democracy, as Nancy Fraser stated in 2013, when she warned of how a certain kind of feminism has become "capitalism's handmaiden." The gap between the causes of "neoliberal feminism" and the living conditions of most women has drastically widened since the capitalist crisis that began in 2007. By that time, as journalist Nina Power said in 2009, "the argument about getting women, ethnic minorities and homosexuals into 'top positions' [was] an argument that [was] being won by the right." The term feminism has lost its radical character and arguments about women's rights and inclusion may be employed by the right- from Sarah Palin, to supposed "pro life feminism." You may be interested in Women's Emancipation in Times of Global Crisis Although Obama's arrival to the White House seemed to indicate the start of an era of change, the inclusion particularly of women in top political positions had already begun to call into question the benefits of representation without questioning imperialist democracy. But if there was one moment that clearly showcased the failure of that "progressive neoliberalism," in the words of Nancy Fraser, it was Hillary Clinton's defeat. Her presentation as a "natural" feminist candidate merely laid bare her failure to get most women behind a historic "feat" that they felt did not represent them. And what's worse, thanks to the compromises made by that feminism, which embraced individualism and meritocracy in the guise of "free choice," the repudiation of Clinton and what she represented threw some white women into the arms of the Ivanka Trump's "entrepreneurial (and conservative) feminism," leading them to minimize her father's misogynist profile and support him at the polling booths. For women, like for many other sectors, Trump's election clearly increases the likelihood of the continued restriction of their rights. But far from the skepticism towards mass movements displayed by liberals and Democratic Party apologists, one of the first reactions was a massive Women's March in the country's major cities, with several limitations and challenges ahead, but that also indicates the emergence of women's protests at the core of imperialist capitalism. In different countries like Argentina and Poland, women are taking to the streets spontaneously in response to the most brutal manifestations of capitalism in the form of patriarchal violence or conservative reactions to reproductive rights. Equal pay for equal work protests have also reemerged, laying bare the inequalities maintained under capitalism even in supposedly egalitarian countries like Iceland. In many countries, women's protests are a means of expression of broader discontent, of the resistance to general attacks launched by businessmen and their governments against the living conditions of the working class and impoverished sectors, in which women are a majority. The inevitable defeat that "neoliberal feminism" has led us to highlights the necessity to link the struggle against patriarchal oppression with the fight against capitalism. This is why causes that at first seem to be "female" causes galvanize and gain the support of a large part of the population enduring the evils of capitalism. The year that started with the threat of Hurricane Trump coincides with the centennial of the revolution that made women's emancipation an urgent agenda, granting them unconditional elemental freedoms that were unthinkable for the female masses of the time, such as the right to divorce or to have an abortion. In just a few months, the Russian Revolution showed the transformative potential of the revolution in contrast with the slow and conditional progress under capitalist democracies that would take a hundred years to achieve some of the same objectives. The anniversary of the Russian Revolution is also a chance to recover its legacy and incorporate it into a women's movement that could merge with the struggles of the working class. Our fight for emancipation marches to the impatient beat of the majority of women who aspire not only to free themselves from gender oppression and subjugation, but also to free humanity from all exploitation and oppression. Tags: #ResistTrumpDonald TrumpWomens' Rights Fight Trump, Keep Dems at Bay: The Case Against a Popular Front Refugees: The End of the German Illusion Celeste is a leader of the Socialist Workers' Party (PTS) and the women's group Pan y Rosas (Bread and Roses) in Argentina. She is a host of the radio program El Círculo Rojo where she focusses on culture and gender. David Harvey and Robert Brenner Discuss the Economy and Donald Trump The two marxist scholars exchange on the current economic situation and the tasks ahead. They share interpretations about the victory ... Trump's anti-immigrant executive order and refugee ban ...

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In his August 20 Facebook post, Ian Somerhalder shares a 'mind-blowing' article written by his wife Nikki Reed for Elle.com. He says 'It's what I want to spend the rest of my life doing-finding solutions to old and dangerous problems'. He has spent many years in his 'Vampire Diaries' chair thinking about his character Damon's life, his own and the planet… He has met many people of varying ages who 'inspire' him and those around them are some of the most impactful moments and relationships he's ever known. Nikki Reed inspires him to DO and BE more so our world can be a better place. What lead her to this train of thought is the Humane Society is currently supporting a shelter in Louisiana that is run by prison inmates. 'The Humane Society gave this shelter the tools and the insight it needed to function. The shelter then gave the inmates the insight they needed to find purpose-to do better.' and it worked. 'So let's start changing our approach altogether The lack of compassion we find in kids that are obsessed with violent video games or who threaten their peers online have one thing in common-their interactions aren't rooted in anything real You can't see, touch or smell anything through a screen' you aren't truly communicating with anyone.' This tends to have a numbing affect and after a while they don't see how their actions affect the planet.. If everyone saw the positive not the negative in people 'what a wonderful world it would be. Nikki wants to know what makes you 'feel good about yourself,…can you dance ,write,sing,run, swim, recite poetry, play the piano., She wants people to email her directly for a chance to be mentioned in the next edition of her column. Thanks to http://facebook.com/iansomerhalder and http://tinyurl.com/omj40yj for the information. Please read.

Clive Rowe, Information Technology, Project, and Business Consulting. Information Technology, Project, and Business Consulting. On its own a dictionary is just a collection of words. An author helps those words tell their story. On its own information is just a collection of numbers. I can help your numbers tell their story. Numbers, like words, mean nothing on their own. Those numbers must be crafted into a story that is accurate, true, and compelling. I can help you find the story behind your data. That story will be accurate (factually correct), true (representing some worthwhile insight), and compelling (understandable in a way that leads to action). I am a business analyst and project manager with a wide range of experience. Someone who understands business and technology. A professional who can work with technical or business teams. A clear and effective communicator. A resource you can rely on. Twenty years experience in IT and business reengineering projects. Understand the interdependencies of business and technology: have written business requirements documents, developed functional and technical specifications, performed risk analysis, and mapped business processes. Extensive experience with the UniVerse MultiValue database (part of the IBM U2 family). Performed risk analysis and maintained risk management plans. Created prototype for electronic data collection and processing, replacing paper forms and faxes with customer self-service model. Managed projects that created, trader support (market "dashboard"), and trade management (track the performance of individual trades) systems. Analyzed client business processes to create efficiencies, generate cost savings, and ensure compliance with federal regulations (HIPAA). Worked with a Six Sigma team to map business processes and develop quality metrics. Designed a proprietary trading system (market timing and position sizing). Performed modeling, statistical analysis, and back testing of proprietary trading systems. Twenty years of experience across many industries and in three countries. Provided solutions, programmed software, and analyzed problems in a variety of business areas. These include, supply chain management, postal operations, finance, reinsurance (including a Lloyd's of London syndicate), legal practice management, membership and subscription, and wholesale distribution. UniVerse® is a trademark of International Business Machines Corporation. Microsoft®, Excel®, and Visual Basic® are registered trademarks of ... well ... Microsoft.

The closing ceremonies officially wrapped up the 2014 ISAF World Championships today in Santander Spain. The overall event management was not without its challenges with difficult weather conditions forcing race committees to make some controversial decisions throughout the week. With priority placed on maximizing gold fleet racing, some of the silver fleets fell significantly behind including the Lasers with only 5 races in the books and Radial silver completing a total of 4 races to end their event. Canada secured two country qualification spots for Rio 2016 including the Laser and Laser Radial classes. Lee Parkhill (RCYC) & Isabella Bertold (RVYC) both sailed in gold fleet clinching spots for the red and white nation. Greg Douglas (RCYC) was also in reach of securing one of the 12 qualification spots in the Finn however the final day of fleet racing was called off thus dissolving any opportunity of achieving that benchmark. 50% of the country berths were allocated at this event with additional opportunities at 2015 class championships and last chances at continental events in 2015 and 2016. The Canadian team will return home briefly before heading to Florida for their winter season and the next major team qualification event, the Miami World Cup!

Will all four political parties agree to work together for the sake of Derby City Council? Could Labour bow to pressure to return to a committee system in a week that could see all four party leaders sit round the table to thrash it out? Zena HawleyAgenda editor The clock is ticking. The ballot boxes may have been put away, the campaign posters taken down and the losing candidates may be licking their wounds - but the repercussions from the 2018 Derby City Council election are far from over and the four political parties have just over two weeks to sort themselves out. The loss of three seats by Labour, including leader Ranjit Banwait, which resulted in the party relinquishing its one-seat overall majority, and the gaining of two seats by the Conservatives and one seat by UKIP, while the Lib Dems remained unchanged with a total of five seats, has left the council with no overall control. So what happens next? One thing for sure is that the kingmakers in this situation are definitely the Lib Dems. With their five seats they have the power to make or break a bid for power by either the previously ruling Labour group, which now has 23 seats, or the Conservatives, who are on 20 seats. The three seats of UKIP could also prove to be a powerful tool in some of the possible permutations of power sharing too. But Lib Dem group leader Councillor Ruth Skelton, who held her Blagreaves seat comfortably, has said from the start of campaigning back in March that she did not want to enter into a power-sharing coalition with any party. Councillor Ruth Skelton retain her Blagreaves seat for the Lib Dems at the 2018 council election Instead, she wants to see a different form of governance introduced to run the council - the committee system. In recent years, the council has been run using the cabinet system. Derby City Council elections 2018: seven key moments as authority goes to no overall control Under the committee system, a council elects a leader to represent the authority and wield executive power. Power is exercised by a number of committees, made up of councillors in proportion to their parties' representation on the council. If a committee is unable to make a decision, or a minority group wishes to challenge it, the decision may be referred to a meeting of the full council for a final decision. The cabinet system, which has been favoured by Labour up until now, sees the majority party elect a leader, who then chooses a cabinet of eight members (in Derby's case), which makes all the decisions away from the council chamber and then nods them through formally at public cabinet meetings without any debate. It has been said by several political commentators that the cabinet system excludes everyone except the cabinet, even the other councillors from the same majority party. If the committee system was introduced, Ms Skelton feels there would be no need for council leaders from different parties to do deals and she feels optimistic because Derby UKIP and Derby Conservatives are already in favour. Who could replace Ranjit Banwait as Derby Labour group leader? She said: "That means we hope that the Labour group, which has resisted attempts to change the system previously, might come around to what I am suggesting. "The current system means that the electorate and its views are not being represented and it could lead to fairer debate. "I think a move could be made quite quickly if everyone agreed to go down the committee path and it would be good for everyone and what Derby needs. "I am hoping that Labour will listen to reasoned argument on this subject and we can get the city up and moving again. "The Lib Dems are holding a group meeting early this coming week to discuss the situation further." UKIP leader Alan Graves, who successfully defended his Alvaston seat last Thursday, said the council needs to work towards a committee system but said that could take a while to sort out. UKIP's Alan Graves kept his seat by beating Labour's Thomas Spray He said: "I think this cannot be implemented immediately, due to legal council procedures and council officer time. So there is still an interim period where we have to come to some arrangement. "The biggest issue is the resistance of the Conservatives to work with UKIP. They have never supported any of our motions at full council including, ironically, the one in July 2017 to consider introducing a committee system. There is a long way to go before we can see how the future of Derby is looking. Amber Valley Borough Council results - see how the Conservatives increased their majority "Derby wants and demands change, that is very clear. If the three other parties (including UKIP) do not agree on a way forward then Labour would quite happily carry on. It is up to the Conservatives, Liberal Democrats and UKIP to forge some sort of agreement. "All the UKIP councillors on the council have a duty to do the right thing for all those who voted for us." Matthew Holmes, Conservative group leader will be addressing his members on Tuesday to gauge reaction to the election results. Conservative group leader Matthew Holmes He said: "We've been in this situation before back in 2010 and it's a frustrating time for the public and the media because of the uncertainty of moving forward under no overall control. However, the experience I and others gained during that process will stand us in good stead as we work to find a stable way forward for the city. "Clearly the onus is on either Labour as the largest group or the Conservative as the second largest to lead. Where the Lib Dems or UKIP as the two smaller groups could play a part remains to be seen. I can't say what the outcome will be at this stage because, genuinely, I just don't know. "I'm sure they'll be lots of speculation, in fact there already is, but I urge everyone to allow the time needed for a prospective administration to emerge, whatever that may be. The council is still functioning and officers are more than capable of managing areas that find themselves without cabinet steer for the time being. All things politics in Derbyshire Council failed woman who died Ex-Derby Mayor on wife's death Labour group leader to step down Council could cut bin collections "What I would like to re-assurance residents and the business community in Derby is that, in the absence of a council leader, I will be happy to assist if called upon to do so in the period before the council's annual meeting in regard to any urgent matters. I'm sure other senior councillors, regardless of political party, will also do the same." The Labour group, still sore from its mauling at the polls on election night, has to elect a new leader before the party can take up the power struggle on the city council. Councillor Baggy Shanker, speaking on behalf of Labour agreed it was early days to know what the outcome of the next two weeks would be. Independent candidate Phil Ingall and Labour's Baggy Shanker (Image: Derby Telegraph / Ian Hodgkinson) He said: "As a party, we need to heed the message that people in Derby are fed-up with what has been called the city's 'toxic politics'. Our pledges have already been quite clear and we need to speak with the other parties to see which of them shares our vision and if they plan to deliver on the pledges. "For example, we are committed to opening a new pool and performance venue, what do the other parties think of that. And we are committed to no closing libraries and children's centres - who shares that vision? "All four party leaders should sit down together and thrash out this situation. Everyone needs to get together. The Conservatives clearly had a good election night and there is a mandate for change in the city. "I personally would not rule out a committee system but it would not be a return to the old-style it would have to be an alternative one and maybe the compromise would be the introduction of a four-year electoral cycle, unlike the thirds system that we have currently when a third of the council comes up for election each year." Changing to a four-year cycle was put forward by former leader Ranjit Banwait in 2016 but was voted out in full council by the opposition parties. Ranjit Banwait had a colourful four years as Derby City Council leader Perhaps with a hung council the time is right for the four-year cycle, it seems certain that Labour will try to use that as a bargaining chip. One thing is certain, it is important that the four parties sort themselves out in time for Wednesday, May 23 when the new mayor is sworn in during the morning. Then later in the day, the council's annual general meeting takes place when it would be useful to have some agreement among parties otherwise it could be a stalemate situation in the chamber over any motions. But the mayor-making could be the first sign that change is coming. Currently, the deputy mayor is Labour councillor Paul Bayliss, who with Labour backing in the chamber would have automatically step up to become mayor. But now that backing is not forthcoming, it is likely that UKIP, Lib Dem and Conservatives will combine their vote to elect a non-Labour mayor - perhaps a Tory one instead? We've just launched our very own app for Android and Apple devices which can be tailored to deliver the news and sport that you're interested in. UK Independence Party Ranjit Banwait Derby City CouncilFears bad air pollution in Derby has caused 'preventable' Covid deathsBut Derby City Council has denied claims made by the city's former Youth Mayor

Be a Hero, and run for the kids of St. Jude. As a St. Jude Hero, you'll raise funds for the kids of St. Jude while you get fit during the NOCO's First Annual Fitness Festival. The dollars that Heroes raise help ensure that families never receive a bill from St. Jude for treatment, travel, housing or food — because all a family should worry about is helping their child live. The Fort Collins Fitness Festival is designed for people of all fitness levels and provide the opportunity to be part of something brand new for the fitness community in Northern Colorado. Registering as a St. Jude Hero does not provide entry to the event. For more information about the festival and to purchase tickets, please visit the event website at www.fortcollinsfitnessfestival.com. If you have questions or would like more information, please email [email protected], or call 720-440-6402.

Lori Klopp Illustrator, Painter, Graphic Designer, Educator http://www.loriklopp.com Appreciations 37 Lori Klopp web site Lori Klopp design portfolio Illustration West Juried Competition, Society of Illustrators of Los Angeles Applied Arts Photography and Illustration Awards Las Laguna Gallery, Male-Man: Women Artists Depicting Men Juried Show National Art League, 84th Annual Juried Open Exhibition Syracuse University Illustration Program Facebook Page Syracuse University Illustration Program Blog The Baffler Magazine 3x3 Illustration Annual No. 10 About Lori Lori Klopp is an award-winning illustrator, painter, designer and educator based in New York, whose figurative work is defined by a saturated, bawdy palette. She earned an MFA in Illustration from Syracuse University in 2013. Her work has been exhibited in New York, Toronto, Arkansas, New Mexico and… Illustration: "Size Matters" Pinup Parod This series satirizes the pinups that were popular in the mid-twentieth century, particularly those by Gil Elvgren, a proliferate illustrator of cheesy pinups for calendars and advertisements. Illustration: "I Have Something to Say" This portrait series celebrates women who have achieved power in contemporary American politics. Lori Klopp is a member of Creative Cloud. Top Tools Used Member Since: December 29, 2013 Fine Art Portraits Portraits: Bad Girls Illustration — Illustration: I Have Something to Say Illustration: Size Matters

Home/Living/The Countess of Beverly Hills Mansions The Countess of Beverly Hills Mansions 24 Flix Send an email May 26, 2016 Before Paris Hilton and Kim Kardashian, socialite Dorothy Taylor may have been the first Hollywood celebrity who wasn't in the entertainment business. She was the ultimate party host and frequent 1930's scandal rag fodder. Her lovers included Gary Cooper, Bugsy Siegel, George Raft and an Italian count. Dorothy's trip to celebrity fame began after she inherited $12 million in 1916, the equivalent of about $275 million today. The first thing she did with her money was divorce her British aviator husband, Claude Grahame-White, and embark on a long party in Europe's best circles. In 1923, she married Italian Count Carlo Dentice di Frasso, many years her senior. On the outskirts of Rome, the new countess acquired and restored one of Europe's most famous homes, Villa Madama, that had been designed in the sixteenth century by Raphael. It was later used by Benito Mussolini during World War II for National Fascist Party functions. While residing in the villa, actor Gary Cooper was doing a movie in Rome and became quite ill. Dorothy took him in and during his recuperation began an intense affair with him under her husband's nose. Since she and the count were at that point leading separate lives, Dorothy went on with the affair and moved to Hollywood where she purchased a mansion in Beverly Hills. Making friends of some of Hollywood's most important stars through her Cooper connections, Dorothy called in the best decorators and landscapers and created a luxurious estate that was classic Art Deco filmdom glamour. Dorothy and Cooper eventually went their own ways but remained distant friends. She was always known as the woman who taught Gary Cooper how to dress, making him the most elegant man in Hollywood. Through her new Hollywood friends, Dorothy eventually rented her mansion to Marlene Dietrich and headed off to search for sunken treasure on the studio-owned schooner, Metha Nelson; Captain Bligh's ship in the 1935 movie "Mutiny on the Bounty." Also on the ship was American gangster Bugsy Siegel. Although the trip turned into a disaster when the schooner was tossed violently by 70 mile-per-hour gale winds that split the main mast and destroyed the sails, it was the start of a new affair with Bugsy. She always rejected gossip of her association with Bugsy, instead referring to him as Benjamin to her friends. In 1947, Dorothy sold the Beverly Hills house to MGM pianist Jose Iturbi, who lived there until he died in 1980. In 1954, Dorothy died of heart failure in a train compartment while she was traveling with George Raft from Las Vegas to Los Angeles after attending one of Dietrich's performances. Once again for sale, the beautifully preserved Spanish Revival estate hasn't changed much since its heyday in the 1930s when it was featured in "House and Garden." At approximately 8,000 square feet, it has four bedrooms and five baths on 1.12 acres. The home was built for entertaining with large public rooms and although it looks like wallpaper, the walls are covered in hand-painted murals. In the dining room, the walls are mirrored verre églomisé panels that depict towering palms. There is also a two-bedroom guest house and pool nestled within the mature landscaped grounds. The asking price is $26.9 million. Dimitri Velis of Hilton and Hyland in Beverly Hills is the listing agent. Visit TopTenRealEstateDeals.com The Buccaneers Offensive Line Feeds 1000 Families Sandra Bullock's 91 Acre San Diego Compound is for Sale Johnny Depp's Los Angeles Penthouse Collection Nike closes corporate offices for a week-long mental health break Dad's 911 call: I've beaten up my son's assailant Hero of the Day: Real estate exec gives free rent to pizzeria feeding hospitals

Germans Get to Business With Putin By Anatoly Medetsky German business executives sought to improve their chances at Russian tenders and saluted Prime Minister Vladimir Putin's intention to run for president again as they met with him Wednesday. This was the first of the annual meetings to take place since Germany ceded the rank of Russia's biggest trade partner to China last year. "Of course, German investors want more chances in tenders in Russia," Eckhard Cordes, chairman of the Committee on Eastern European Economic Relations, a lobby group of German companies, said in opening remarks. The 20 visiting executives represented companies ranging from giants like energy company E.On, industrial conglomerate BASF and building material group Knauf to midsized businesses. Germany is unlikely to regain its status as the biggest Russian trade partner this year. The countries will likely exchange goods worth close to $70 billion by the end of December, Putin said. Trade with China will climb to $80 billion or more, he said. In a policy paper released in October last year, the Committee on Eastern European Economic Relations noted that Chinese activities in Eastern Europe follow the same pattern that forced German construction companies to pull out of Africa before. Competition from China involved bids "far below the usual … costs" made possible, in part, by hidden state subsidies, the report said. One of Germany's largest companies, Siemens, said earlier this week that Russia accounted for only a fraction of its global sales — 1.4 billion euros ($1.89 billion) out of 73.5 billion euros — in the financial year that ended Sept. 30. Nikolaus Knauf, chairman of the Founders Council of the company that bears his name, downplayed talk that German companies wanted better chances at tenders. There was no further discussion of the subject at the meeting, he said. "Why should we think it's possible that German industry has a better chance of winning?" he said by phone. "The best company with the best quality should have the best chances." Knauf said he was happy to hear that the government earmarked large investment — 30 billion euros over the next three years — to expand and improve the railway system. The company transports 5 million tons of its products in Russia by rail every year, he explained. He drew encouragement from the government's other plans, he said, without identifying them. "It was good to hear that the government is ready to do its best to take the economy forward," he said. Knauf said he also supported Russia's now-imminent entry into the World Trade Organization and the economic reintegration of the former Soviet republics into what could become the Eurasian Union in the longer term. In the opening remarks, Cordes also wished Putin, who already served two terms in the Kremlin from 2000 to 2008, success in the presidential election in March. "It was a very gratifying news for the German economy to know that you decided to run for the post of Russian president in 2012," he said. Incumbent President Dmitry Medvedev proposed in September that the pro-government United Russia party nominate Putin as its candidate, a nomination expected at the party congress later this month. Cordes also proposed in a statement before the meeting that after Russia joins WTO, the European Union should start negotiations about a new free-trade zone between Russia and Europe, independent of the ongoing talks about a new partnership and cooperation agreement. He argued that a free-trade agreement should be modeled on the European Free Trade Association, a group founded in 1960 that comprised states that did not want to join what was then the European Economic Community (later the EU). Commenting on Cordes' suggestion, the EU Delegation's spokesman in Moscow, Soren Liborius, said it would be difficult to open new separate talks. "We fully support promoting trade, but for now we should stick to the format that we have agreed between each other," he said. Putin, in his only public remarks at the meeting, stressed the government's current robust outlook for the economy and outlined some of the joint projects that German and Russian companies are doing or considering, including the Nord Stream pipeline to carry Russian natural gas to Germany under the Baltic Sea. Staff writer Nikolaus von Twickel contributed to this report.

Quality Shines Through Again for Elite… ALincolnshire restaurant and takeaway chain is continuing to fry high after renewing its National Federation of Fish Friers Fish & Chip Quality Award status in Lincoln. The Elite Fish & Chip Company at the Moorland Centre on Tritton Road is the latest restaurant and takeaway in the Lincolnshire chain to have retained the award, which identifies fish and chip outlets that serve the highest quality fish and chips and deliver the best level of service. Each Fish and Chip Quality Award is valid for two years and retention is dependent on standards being maintained. These are awarded by assessors from the National Federation of Fish Friers (NFFF), the trade body that represents the nation's fish and chip shops. Tritton Road's renewal follows the Elite's Ruskington takeaway and restaurant and its sister takeaway Welbourne's in the village receiving the quality award back in August. Shops are scored on presentation, hygiene and cleanliness, staff training, equipment, frying and sales skills and, most importantly, the quality of the cooked product. Owner Adrian Tweedale, said: "After a period of thorough inspection and assessment, we are pleased to hear that Elite has once again come out on top. "All our locations have their own unique charm and continue to be formally recognised for their consistency in providing the highest levels of quality and service. Our commitment to excellence is reflected in the quality of our fish and chips and it's thanks to our committed and enthusiastic staff that we retain these kinds of standards." The NFFF runs the Quality Award scheme as a way of raising standards within the fish and chip trade and enhancing the profile of the industry. It serves to reward and promote shops that provide good quality products and are hygienic, as well as friers who show a high level of competence. There are currently around 250 fish and chip outlets across the country that have been recognised with the NFFF Fish & Chip Quality Award. NFFF President Gregg Howard explained: "The NFFF Fish & Chip Quality Award assessment is extremely comprehensive. It sets the new benchmark for quality within the industry. "We examine everything from food safety to other key aspects of business, from preparation and cooking equipment to the management of paperwork and the traceability of fish. "Adrian and the staff at all of his restaurants and takeaways clearly take pride in where they source their fish and potatoes from. This provides the reassurance to customers that they are being served food made with high-quality ingredients." For more information about The Elite Fish & Chip Company, visit: www.elitefishandchips.com Elite Fish and Chips

I have recently tasted a luscious fruit of modernity for the first time in my life: surgery. It was a simple matter that required less than 30 minutes of my doctor's time; but what a revolution for me. When I awoke from my first experience of anesthesia, I was missing an impacted wisdom tooth that had brought on recurring infections. My tooth was making me sick, so I had it removed. To replace the bone bordering on my sinus cavity, my surgeon inserted a small amount of animal cadaver — sheep, I am told — around which my tissue should rebuild. As a result, I am no longer entirely human. Medical innovation is among the strongest arguments in favor of a progressive view of history. My newly cleared head, secured by the remains of a creature of another species, turns indignantly away from the ancients. Why look backward at all? We have come to a place where I do not have to live with a recurring tooth problem. When I grow a bit older, I may have the option to replace bad knees or hips. Bad arteries can be bypassed. An enormous number of things that once killed — quickly and slowly — have been done away with. Every day is brighter than the one before. We're headed in the right direction. Despite my repaired orofacial arrangements, I can only conclude from human history that I am going to die. (Of your charity, pray it is not too soon.) The end of life may be pushed further out; but for normal humans and even mostly humans like me, the end still exists. And in fact, as the ancients knew, the "end" — in the sense of "purpose" — of human life is embedded in every moment of our time on earth and beyond. Because one day we won't be here, there must be a reason outside ourselves to explain why we are here now. I am overjoyed to be rid of this troublesome tooth, so that I may continue to be a less frequently infected father to my children and priest to my parishioners. In fact, becoming slightly inhuman has made me more aware why I am alive. With or without this surgery — whether I should live 40 years or 80 — I was made to worship and to serve. This is my end. I live now as ever in a time vortex connected to history's apex, Anno Domini. The world cannot believe that the most important event in its history has already happened. We want a different kind of "world without end" than that which the Church proclaims. And the only place to find it is beyond humanity — to imagine ourselves capable of defining our own existence, altering it, and eternalizing it. We must redefine our "end" to arrive at another end — namely, physical death is not inevitable. My partly sheep-boned jaw is a miniature example of the striving of our race to arrive, perversely, at what we are not. I am physically less myself (not more) than I was before my surgery. Likewise, striving to "be myself" may take me further away from rather than closer to the person I was made to be. If my "end" is myself, then obviously I want and need myself to conform to my feelings and, fantastically, to go on as such for longer and longer stretches of time, according to what tomorrow's therapeutic technologies can afford. As a Christian, I believe that I will live forever, but not because I am my own reason for being. If dying in Christ is the path to living with Christ, then my existence is primarily about my Creator and only secondarily about me. I therefore do not define who I am, regardless of whatever condition I may feel in my emotional or physical state. Indeed, St. Paul would no doubt be perplexed with the all-too-common 21st-century sentence that begins, I feel like. Why? Because, he reminds the Corinthians and us too, "you are not your own" (1 Cor. 6:19). On the contrary, modernity tells us we are our own, and our pitiful religion is that of the sovereign self. Wotan learns in Wagner's opera Siegfried that every man is his own god, who breaks the one staff of divine law, crafted from the sacred ash tree of the world. Each of us is his own master, even a three-year-old boy whose parents let him live as a girl. But mass autocracy comes at high costs — among them, harrowing stories of people whose self-construction leads only to the discovery that drastic measures have failed to reveal their true nature. Wounds fester instead of heal. The real self fades. Progress takes us from perfect freedom as worship of God, to an illusion of freedom as worship of a broken me. And still the world bangs its sad drum: The right step toward the right version of you is just around the next bend. Bear with us. Please! I have recently taken interest in Jonathan Swift's great work Gulliver's Travels, and I agree with Allan Bloom and Harvey Mansfield that Swift sees the "end" (purpose) of scientific progress, at least in part, as the end of the world. Swift's concern looks ahead to the astonishing thesis by Rousseau almost a century later: Nature must be overcome. Swift predicts the folly of such thinking in the case of the floating island of Laputa, whose technological prowess results in an absurd system of domestic neglect coupled with tyranny over neighbors. Innovations inevitably involve errors of judgment that wreck both the Laputans and everyone else. Meanwhile here I sit, transhuman, often prone to thrashing out my frustration at the prospect of further progress. But I am not my own. My becoming part sheep is not the end of the world. I have accepted a bit of ovine anatomy into my body as an alien presence, and a welcome one. But the real me is hidden with God in Christ, living for Resurrection Day. I know my end. Whatever I am now belongs once and for all to the great I am, whose will for me is total transformation into incorruptibility — to be what I am not, and thus more human than I have ever been. If I acquire more inhumanity in my body before then, may I live these unnaturally long years with blessed biological aberrations only to praise my God. If the increasingly animal or robotic me ceases to do this, I pray someone will melt me down immediately.

Decision support tools for agriculture: towards effective design and delivery David C. Rose, William J. Sutherland, Caroline Parker, Matt Lobley, Michael Winter, Carol Morris, Susan Twining, Charles Ffoulkes, Tatsuya Amano, Lynn V. Dicks Decision support tools, usually considered to be software-based, may be an important part of the quest for evidence-based decision-making in agriculture to improve productivity and environmental outputs. These tools can lead users through clear steps and suggest optimal decision paths or may act more as information sources to improve the evidence base for decisions. Yet, despite their availability in a wide range of formats, studies in several countries have shown uptake to be disappointingly low. This paper uses a mixed methods approach to investigate the factors affecting the uptake and use of decision support tools by farmers and advisers in the UK. Through a combination of qualitative interviews and quantitative surveys, we found that fifteen factors are influential in convincing farmers and advisers to use decision support tools, which include usability, cost-effectiveness, performance, relevance to user, and compatibility with compliance demands. This study finds a plethora of agricultural decision support tools in operation in the UK, yet, like other studies, shows that their uptake is low. A better understanding of the fifteen factors identified should lead to more effective design and delivery of tools in the future. https://doi.org/10.1016/j.agsy.2016.09.009 Published - Nov 2016 Decision support systems Evidence-based decision-making Human-computer interactions, sustainable intensification 10.1016/j.agsy.2016.09.009 Rose, D.C. et al (2018) Decision support tools for agriculture: towards effective design and delivery © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Dive into the research topics of 'Decision support tools for agriculture: towards effective design and delivery'. Together they form a unique fingerprint. agriculture Agriculture & Biology 100% farmers Agriculture & Biology 95% information sources Agriculture & Biology 79% cost effectiveness Agriculture & Biology 72% compliance Agriculture & Biology 70% decision making Agriculture & Biology 67% interviews Agriculture & Biology 65% methodology Agriculture & Biology 18% Rose, D. C., Sutherland, W. J., Parker, C., Lobley, M., Winter, M., Morris, C., Twining, S., Ffoulkes, C., Amano, T., & Dicks, L. V. (2016). Decision support tools for agriculture: towards effective design and delivery. Agricultural Systems, 149, 165-174. https://doi.org/10.1016/j.agsy.2016.09.009 Rose, David C. ; Sutherland, William J. ; Parker, Caroline ; Lobley, Matt ; Winter, Michael ; Morris, Carol ; Twining, Susan ; Ffoulkes, Charles ; Amano, Tatsuya ; Dicks, Lynn V. / Decision support tools for agriculture: towards effective design and delivery. In: Agricultural Systems. 2016 ; Vol. 149. pp. 165-174. @article{8fe0f79890ce411aa3df6f1899a87556, title = "Decision support tools for agriculture: towards effective design and delivery", abstract = "Decision support tools, usually considered to be software-based, may be an important part of the quest for evidence-based decision-making in agriculture to improve productivity and environmental outputs. These tools can lead users through clear steps and suggest optimal decision paths or may act more as information sources to improve the evidence base for decisions. Yet, despite their availability in a wide range of formats, studies in several countries have shown uptake to be disappointingly low. This paper uses a mixed methods approach to investigate the factors affecting the uptake and use of decision support tools by farmers and advisers in the UK. Through a combination of qualitative interviews and quantitative surveys, we found that fifteen factors are influential in convincing farmers and advisers to use decision support tools, which include usability, cost-effectiveness, performance, relevance to user, and compatibility with compliance demands. This study finds a plethora of agricultural decision support tools in operation in the UK, yet, like other studies, shows that their uptake is low. A better understanding of the fifteen factors identified should lead to more effective design and delivery of tools in the future.", keywords = "Decision support systems, Decision support tools, Evidence-based decision-making, Human-computer interactions, sustainable intensification", author = "Rose, {David C.} and Sutherland, {William J.} and Caroline Parker and Matt Lobley and Michael Winter and Carol Morris and Susan Twining and Charles Ffoulkes and Tatsuya Amano and Dicks, {Lynn V.}", note = "OA article Funding: Open Access funded by Natural Environment Research Council ", doi = "10.1016/j.agsy.2016.09.009", journal = "Agricultural Systems", Rose, DC, Sutherland, WJ, Parker, C, Lobley, M, Winter, M, Morris, C, Twining, S, Ffoulkes, C, Amano, T & Dicks, LV 2016, 'Decision support tools for agriculture: towards effective design and delivery', Agricultural Systems, vol. 149, pp. 165-174. https://doi.org/10.1016/j.agsy.2016.09.009 Decision support tools for agriculture: towards effective design and delivery. / Rose, David C.; Sutherland, William J.; Parker, Caroline; Lobley, Matt; Winter, Michael; Morris, Carol; Twining, Susan; Ffoulkes, Charles; Amano, Tatsuya; Dicks, Lynn V. In: Agricultural Systems, Vol. 149, 11.2016, p. 165-174. T1 - Decision support tools for agriculture: towards effective design and delivery AU - Rose, David C. AU - Sutherland, William J. AU - Parker, Caroline AU - Lobley, Matt AU - Winter, Michael AU - Morris, Carol AU - Twining, Susan AU - Ffoulkes, Charles AU - Amano, Tatsuya AU - Dicks, Lynn V. N1 - OA article Funding: Open Access funded by Natural Environment Research Council N2 - Decision support tools, usually considered to be software-based, may be an important part of the quest for evidence-based decision-making in agriculture to improve productivity and environmental outputs. These tools can lead users through clear steps and suggest optimal decision paths or may act more as information sources to improve the evidence base for decisions. Yet, despite their availability in a wide range of formats, studies in several countries have shown uptake to be disappointingly low. This paper uses a mixed methods approach to investigate the factors affecting the uptake and use of decision support tools by farmers and advisers in the UK. Through a combination of qualitative interviews and quantitative surveys, we found that fifteen factors are influential in convincing farmers and advisers to use decision support tools, which include usability, cost-effectiveness, performance, relevance to user, and compatibility with compliance demands. This study finds a plethora of agricultural decision support tools in operation in the UK, yet, like other studies, shows that their uptake is low. A better understanding of the fifteen factors identified should lead to more effective design and delivery of tools in the future. AB - Decision support tools, usually considered to be software-based, may be an important part of the quest for evidence-based decision-making in agriculture to improve productivity and environmental outputs. These tools can lead users through clear steps and suggest optimal decision paths or may act more as information sources to improve the evidence base for decisions. Yet, despite their availability in a wide range of formats, studies in several countries have shown uptake to be disappointingly low. This paper uses a mixed methods approach to investigate the factors affecting the uptake and use of decision support tools by farmers and advisers in the UK. Through a combination of qualitative interviews and quantitative surveys, we found that fifteen factors are influential in convincing farmers and advisers to use decision support tools, which include usability, cost-effectiveness, performance, relevance to user, and compatibility with compliance demands. This study finds a plethora of agricultural decision support tools in operation in the UK, yet, like other studies, shows that their uptake is low. A better understanding of the fifteen factors identified should lead to more effective design and delivery of tools in the future. KW - Decision support systems KW - Decision support tools KW - Evidence-based decision-making KW - Human-computer interactions, sustainable intensification U2 - 10.1016/j.agsy.2016.09.009 DO - 10.1016/j.agsy.2016.09.009 JO - Agricultural Systems JF - Agricultural Systems Rose DC, Sutherland WJ, Parker C, Lobley M, Winter M, Morris C et al. Decision support tools for agriculture: towards effective design and delivery. Agricultural Systems. 2016 Nov;149:165-174. https://doi.org/10.1016/j.agsy.2016.09.009