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A database storing the sequence alignments of the most conserved regions of protein families. These alignments are used to derive the BLOSUM matrices. Only the sequences with a percentage of identity lower than the threshold are used.
By using the block, counting the pairs of amino acids in each column of the multiple alignment. | 1 | Applied and Interdisciplinary Chemistry |
The reaction mechanism of allylic C-H acetoxylation has been studied. The first step in the catalytic cycle is cleavage of the allylic C-H bond. The sulfoxide ligand is thought to promote this step by generating a highly electrophilic, possibly cationic palladium species in situ. This species coordinates to the alkene and acidifies the adjacent C-H bond, which allows acetate to abstract the proton and forms a π-allyl palladium complex (II). Subsequently, a π-acid such as benzoquinone coordinates to the palladium, activating the π-allyl complex to nucleophilic attack (III). A nucleophile, in this case acetate, attacks to reductively eliminate palladium, generating the product and palladium(0) (IV). The palladium(0) is reoxidized to palladium(II) by benzoquinone and the sulfoxide ligand reassociates, closing the catalytic cycle. | 0 | Theoretical and Fundamental Chemistry |
In the 2000s the application of the bulk material analyzer was extended to include minerals. Today, analyzers are found in copper, iron ore, and phosphates, to name a few. One of the advantages of these analyzers is the timeliness of information for the user. Another is the avoidance of physical sampling. | 0 | Theoretical and Fundamental Chemistry |
Scientists found a variety of rock types in the Columbia Hills, and they placed them into six different categories. The six are: Adirondack, Clovis, Wishstone, Peace, Watchtower, Backstay, and Independence. They are named after a prominent rock in each group. Their chemical compositions, as measured by APXS, are significantly different from each other. Most importantly, all of the rocks in Columbia Hills show various degrees of alteration due to aqueous fluids.
They are enriched in the elements phosphorus, sulfur, chlorine, and bromine—all of which can be carried around in water solutions. The Columbia Hills' rocks contain basaltic glass, along with varying amounts of olivine and sulfates.
The olivine abundance varies inversely with the amount of sulfates. This is exactly what is expected because water destroys olivine but helps to produce sulfates.
The Clovis group is especially interesting because the Mossbauer spectrometer (MB) detected goethite in it. Goethite forms only in the presence of water, so its discovery is the first direct evidence of past water in the Columbia Hills's rocks. In addition, the MB spectra of rocks and outcrops displayed a strong decline in olivine presence, although the rocks probably once contained much olivine. Olivine is a marker for the lack of water because it easily decomposes in the presence of water. Sulfate was found, and it needs water to form.
Wishstone contained a great deal of plagioclase, some olivine, and anhydrate (a sulfate). Peace rocks showed sulfur and strong evidence for bound water, so hydrated sulfates are suspected. Watchtower class rocks lack olivine consequently they may have been altered by water. The Independence class showed some signs of clay (perhaps montmorillonite a member of the smectite group). Clays require fairly long term exposure to water to form.
One type of soil, called Paso Robles, from the Columbia Hills, may be an evaporate deposit because it contains large amounts of sulfur, phosphorus, calcium, and iron. Also, MB found that much of the iron in Paso Robles soil was of the oxidized, Fe form, which would happen if water had been present.
Towards the middle of the six-year mission (a mission that was supposed to last only 90 days), large amounts of pure silica were found in the soil. The silica could have come from the interaction of soil with acid vapors produced by volcanic activity in the presence of water or from water in a hot spring environment.
After Spirit stopped working scientists studied old data from the Miniature Thermal Emission Spectrometer, or Mini-TES and confirmed the presence of large amounts of carbonate-rich rocks, which means that regions of the planet may have once harbored water. The carbonates were discovered in an outcrop of rocks called "Comanche."
In summary, Spirit found evidence of slight weathering on the plains of Gusev, but no evidence that a lake was there. However, in the Columbia Hills there was clear evidence for a moderate amount of aqueous weathering. The evidence included sulfates and the minerals goethite and carbonates which only form in the presence of water. It is believed that Gusev crater may have held a lake long ago, but it has since been covered by igneous materials. All the dust contains a magnetic component which was identified as magnetite with some titanium. Furthermore, the thin coating of dust that covers everything on Mars is the same in all parts of the planet. | 0 | Theoretical and Fundamental Chemistry |
There are drugs, called depolarization blocking agents, that cause prolonged depolarization by opening channels responsible for depolarization and not allowing them to close, preventing repolarization. Examples include the nicotinic agonists, suxamethonium and decamethonium. | 0 | Theoretical and Fundamental Chemistry |
For turbulent jet, , the linear terms in the equation can be neglected everywhere except near a small boundary layer along the wall. Then neglecting the non-slip conditions at the wall, the solution is given by
In the case of axisymmetric turbulent plumes where the entrainment rate per unit axial length of the plume increases like , Taylor's solution is given by where is a constant, is the specific buoyancy flux and
in which denotes the associated Legendre function of the first kind with degree and order . | 1 | Applied and Interdisciplinary Chemistry |
Adrenergic agonists that are selective for the β subtype cause bronchial dilation and might be expected to relieve the bronchospasm of an asthmatic attack. Nonselective β-agonists have stimulatory cardiac effects and therefore have limited use in cardiac patients with asthma.
Administration of higher doses of short-acting β-agonists increases duration of action but also increases side effects such as cardiac effects. One approach to avoid these side effects is to use structurally different features that may minimize absorption into systemic circulation. For example, one could use drugs that transform into inactive metabolites upon entry into systemic circulation.
Substituents on the pharmacophore influence whether an analog will be direct- or indirect-acting or a mixture of both. It also influences the specificity for the β-receptor subtypes. Direct-acting analog binds the β-adrenergic receptors directly and generates sympathetic response. Indirect-acting analog causes agonistic effect but without a direct binding to the β-adrenergic receptor, for example, by promoting release of norepinephrine (NE) from the presynaptic terminal or by inhibiting reuptake of released NE. | 1 | Applied and Interdisciplinary Chemistry |
In 2003, a research team inserted genes into the brain for the first time. They used liposomes coated in a polymer called polyethylene glycol, which unlike viral vectors, are small enough to cross the blood–brain barrier.
Short pieces of double-stranded RNA (short, interfering RNAs or siRNAs) are used by cells to degrade RNA of a particular sequence. If a siRNA is designed to match the RNA copied from a faulty gene, then the abnormal protein product of that gene will not be produced.
Gendicine is a cancer gene therapy that delivers the tumor suppressor gene p53 using an engineered adenovirus. In 2003, it was approved in China for the treatment of head and neck squamous cell carcinoma. | 1 | Applied and Interdisciplinary Chemistry |
Magnetorheological dampers are under development for use in military and commercial helicopter cockpit seats, as safety devices in the event of a crash. They would be used to decrease the shock delivered to a passenger's spinal column, thereby decreasing the rate of permanent injury during a crash. | 1 | Applied and Interdisciplinary Chemistry |
The insertion of carbon monoxide into a metal-carbon bond to form an acyl group is the basis of carbonylation reactions, which provides many commercially useful products. | 0 | Theoretical and Fundamental Chemistry |
The effect of airfoil geometry on dynamic stall is quite intricate. As is shown in the figure, for a cambered airfoil, the lift stall is delayed and the maximum nose-down pitch moment is significantly reduced. On the other hand, the inception of stall is more abrupt for a sharp leading-edge airfoil. More information is available here. | 1 | Applied and Interdisciplinary Chemistry |
An analytical calculation of the VIPA was first performed by Vega and Weiner in 2003 based on the theory of plane waves and an improved model based on the Fresnel diffraction theory was developed by Xiao and Weiner in 2004. | 0 | Theoretical and Fundamental Chemistry |
Orifice plates are most commonly used to measure flow rates in pipes, when the fluid is single-phase (rather than being a mixture of gases and liquids, or of liquids and solids) and well-mixed, the flow is continuous rather than pulsating, the fluid occupies the entire pipe (precluding silt or trapped gas), the flow profile is even and well-developed and the fluid and flow rate meet certain other conditions. Under these circumstances and when the orifice plate is constructed and installed according to appropriate standards, the flow rate can easily be determined using published formulae based on substantial research and published in industry, national and international standards.
An orifice plate is called a calibrated orifice if it has been calibrated with an appropriate fluid flow and a traceable flow measurement device.
Plates are commonly made with sharp-edged circular orifices and installed concentric with the pipe and with pressure tappings at one of three standard pairs of distances upstream and downstream of the plate; these types are covered by ISO 5167 and other major standards. There are many other possibilities. The edges may be rounded or conical, the plate may have an orifice the same size as the pipe except for a segment at top or bottom which is obstructed, the orifice may be installed eccentric to the pipe, and the pressure tappings may be at other positions. Variations on these possibilities are covered in various standards and handbooks. Each combination gives rise to different coefficients of discharge which can be predicted so long as various conditions are met, conditions which differ from one type to another.
Once the orifice plate is designed and installed, the flow rate can often be indicated with an acceptably low uncertainty simply by taking the square root of the differential pressure across the orifice's pressure tappings and applying an appropriate constant.
Orifice plates are also used to reduce pressure or restrict flow, in which case they are often called restriction plates. | 1 | Applied and Interdisciplinary Chemistry |
Aged reagent can be destroyed with dilute acid to prevent the formation of the highly explosive silver nitride. | 0 | Theoretical and Fundamental Chemistry |
The formation of methylene blue after the reaction of hydrogen sulfide with dimethyl-p-phenylenediamine and iron(III) at pH 0.4 – 0.7 is used to determine by photometric measurements sulfide concentration in the range 0.020 to 1.50 mg/L (20 ppb to 1.5 ppm). The test is very sensitive and the blue coloration developing upon contact of the reagents with dissolved HS is stable for 60 min. Ready-to-use kits such as the Spectroquant sulfide test facilitate routine analyses. The methylene blue sulfide test is a convenient method often used in soil microbiology to quickly detect in water the metabolic activity of sulfate reducing bacteria (SRB). It must be noted that in this colorimetric test, methylene blue is a product formed by the reaction and not a reagent added to the system.
The addition of a strong reducing agent, such as ascorbic acid, to a sulfide-containing solution is sometimes used to prevent sulfide oxidation from atmospheric oxygen. Although it is certainly a sound precaution for the determination of sulfide with an ion selective electrode, it might however hamper the development of the blue color if the freshly formed methylene blue is also reduced, as described here above in the paragraph on redox indicator. | 0 | Theoretical and Fundamental Chemistry |
The z-average molar mass is the third moment or third power average molar mass, which is calculated by
The z-average molar mass can be determined with ultracentrifugation. The melt elasticity of a polymer is dependent on . | 0 | Theoretical and Fundamental Chemistry |
Activated carbon is a highly porous, amorphous solid consisting of microcrystallites with a graphite lattice, usually prepared in small pellets or a powder. It is non-polar and cheap. One of its main drawbacks is that it reacts with oxygen at moderate temperatures (over 300 °C).
Activated carbon can be manufactured from carbonaceous material, including coal (bituminous, subbituminous, and lignite), peat, wood, or nutshells (e.g., coconut). The manufacturing process consists of two phases, carbonization and activation. The carbonization process includes drying and then heating to separate by-products, including tars and other hydrocarbons from the raw material, as well as to drive off any gases generated. The process is completed by heating the material over in an oxygen-free atmosphere that cannot support combustion. The carbonized particles are then "activated" by exposing them to an oxidizing agent, usually steam or carbon dioxide at high temperature. This agent burns off the pore blocking structures created during the carbonization phase and so, they develop a porous, three-dimensional graphite lattice structure. The size of the pores developed during activation is a function of the time that they spend in this stage. Longer exposure times result in larger pore sizes. The most popular aqueous phase carbons are bituminous based because of their hardness, abrasion resistance, pore size distribution, and low cost, but their effectiveness needs to be tested in each application to determine the optimal product.
Activated carbon is used for adsorption of organic substances and non-polar adsorbates and it is also usually used for waste gas (and waste water) treatment. It is the most widely used adsorbent since most of its chemical (e.g. surface groups) and physical properties (e.g. pore size distribution and surface area) can be tuned according to what is needed. Its usefulness also derives from its large micropore (and sometimes mesopore) volume and the resulting high surface area. Recent research works reported activated carbon as an effective agent to adsorb cationic species of toxic metals from multi-pollutant systems and also proposed possible adsorption mechanisms with supporting evidences. | 0 | Theoretical and Fundamental Chemistry |
Erosion corrosion is a degradation of material surface due to mechanical action, often by impinging liquid, abrasion by a slurry, particles suspended in fast flowing liquid or gas, bubbles or droplets, cavitation, etc. The mechanism can be described as follows:
* mechanical erosion of the material, or protective (or passive) oxide layer on its surface,
* enhanced corrosion of the material, if the corrosion rate of the material depends on the thickness of the oxide layer.
The mechanism of erosion corrosion, the materials affected by it, and the conditions when it occurs are generally different from that of flow-accelerated corrosion, although the last one is sometimes classified as a sub-type of erosion corrosion. | 1 | Applied and Interdisciplinary Chemistry |
The treatment of this type of data is similar to the treatment of absorbance data. In fact the equation defining the relation between fluorescent intensity and species' concentrations is very similar.
where is the fluorescent intensity of the ith species at unit concentration. | 0 | Theoretical and Fundamental Chemistry |
Modons or dipole eddy pairs, are eddies that can carry water over distances of more than 1000 km in the ocean, in different directions than usual sea currents like Rossby waves, and much faster than other eddies. | 1 | Applied and Interdisciplinary Chemistry |
Some of the early calculations of the polarization vector were based on
direct inversion and the implementation of the conjugate gradient method by Petravic and Kuo-Petravic. Subsequently, many other conjugate gradient methods have been tested. Advances in the preconditioning of linear systems of equations arising in the DDA setup have also been reported. | 0 | Theoretical and Fundamental Chemistry |
In 2010, the International Fragrance Association published a list of 3,059 chemicals used in 2011 based on a voluntary survey of its members, identifying about 90% of the world's production volume of fragrances. | 0 | Theoretical and Fundamental Chemistry |
At GABAergic synapses, the cycle is called the GABA-glutamine cycle. Here the glutamine taken up by neurons is converted to glutamate, which is then metabolized into GABA by glutamate decarboxylase (GAD). Upon release, GABA is taken up into astrocytes via GABA transporters and then catabolized into succinate by the joint actions of GABA transaminase and succinate-semialdehyde dehydrogenase. Glutamine is synthesized from succinate via the TCA cycle, which includes a condensation reaction of oxaloacetate and acetyl-CoA-forming citrate. Then the synthesis of α-ketoglutarate and glutamate occurs, after which glutamate is again metabolized into GABA by GAD. The supply of glutamine to GABAergic neurons is less significant, because these neurons exhibit a larger proportion of reuptake of the released neurotransmitter compared to their glutamatergic counterparts | 1 | Applied and Interdisciplinary Chemistry |
In astrophysics, Chandrasekhar's variational principle provides the stability criterion for a static barotropic star, subjected to radial perturbation, named after the Indian American astrophysicist Subrahmanyan Chandrasekhar. | 1 | Applied and Interdisciplinary Chemistry |
A major importance of macromolecular crowding to biological systems stems from its effect on protein folding. The underlying physical mechanism by which macromolecular crowding helps to stabilize proteins in their folded state is often explained in terms of excluded volume - the volume inaccessible to the proteins due to their interaction with macromolecular crowders. This notion goes back to Asakura and Oosawa, who have described depletion forces induced by steric, hard-core, interactions. A hallmark of the mechanism inferred from the above is that the effect is completely a-thermal, and thus completely entropic. These ideas were also proposed to explain why small cosolutes, namely protective osmolytes, which are preferentially excluded from proteins, also shift the protein folding equilibrium towards the folded state. However, it has been shown by various methods, both experimental and theoretical, that depletion forces are not always entropic in nature. | 0 | Theoretical and Fundamental Chemistry |
The EC set maximum residue levels for diphenylamine in 2005. (Annex II and Part B of Annex III to Regulation (EC) No 396/2005). Diphenylamine was one of 84 substances of a European Commission (EC) review program covered by a regulation from 2002 requiring the European Food Safety Authority (EFSA) upon EC request to organize a peer review of the initial evaluation, i.e. a draft risk assessment, and to provide the EC within 6 months with a conclusion. The assessment, received by the EFSA in 2007 started the peer review in October 2007 by dispatching it for consultation of the EC member states and the applicants, the two manufacturers, Cerexagri s.a., Italian subsidiary of United Phosphorus Ltd (UPL), and Pace International LLC. As a result of the peer review, mostly lacking data about risk to consumers, and particularly the levels and toxicity of unidentified metabolites of the substance, the possible formation of nitrosamines during storage of the active substance and during processing of treated apples, and the lack of data on the potential breakdown product of diphenylamine residues in processed commodities, the EC decided on 30 November 2009 to withdraw authorizations for plant protection products containing diphenylamine.(2009/859/EC)
The European Diphenylamine Task Force resubmitted an application to the EC with more data, and an additional report was received by the EFSA on 3 December 2010. EFSA concluded the risk assessment did not eliminate the concerns on 5 December 2011, published this opinion in 2012 and it became law in 2013. | 0 | Theoretical and Fundamental Chemistry |
Modified Lak wettability index exists which is based on the areas below water and oil relative permeability curves.
where
: : modified Lak wettability index (index values near -1 and 1 represent strongly oil-wet and strongly water-wet rocks, respectively)
: : Area under the oil relative permeability curve
: : Area under the water relative permeability curve | 0 | Theoretical and Fundamental Chemistry |
1,2-substituted cyclopropane has a meso cis-isomer (molecule has a mirror plane) and two trans-enantiomers:
The two cis stereoisomers of 1,2-substituted cyclohexanes behave like meso compounds at room temperature in most cases. At room temperature, most 1,2-disubstituted cyclohexanes undergo rapid ring flipping (exceptions being rings with bulky substituents), and as a result, the two cis stereoisomers behave chemically identically with chiral reagents. At low temperatures, however, this is not the case, as the activation energy for the ring-flip cannot be overcome, and they therefore behave like enantiomers. Also noteworthy is the fact that when a cyclohexane undergoes a ring flip, the absolute configurations of the stereocenters do not change. | 0 | Theoretical and Fundamental Chemistry |
In general, most biochemical reactions are stereoselective, so only one stereoisomer will produce the intended product while the other simply does not participate or can cause side-effects. Of note, the form of amino acids and the form of sugars (primarily glucose) are usually the biologically reactive form. This is due to the fact that many biological molecules are chiral and thus the reactions between specific enantiomers produce pure stereoisomers. Also notable is the fact that all amino acid residues exist in the form. However, bacteria produce -amino acid residues that polymerize into short polypeptides which can be found in bacterial cell walls. These polypeptides are less digestible by peptidases and are synthesized by bacterial enzymes instead of mRNA translation which would normally produce -amino acids.
The stereoselective nature of most biochemical reactions meant that different enantiomers of a chemical may have different properties and effects on a person. Many psychotropic drugs show differing activity or efficacy between isomers, e.g. amphetamine is often dispensed as racemic salts while the more active dextroamphetamine is reserved for refractory cases or more severe indications; another example is methadone, of which one isomer has activity as an opioid agonist and the other as an NMDA antagonist.
Racemization of pharmaceutical drugs can occur in vivo. Thalidomide as the (R) enantiomer is effective against morning sickness, while the (S) enantiomer is teratogenic, causing birth defects when taken in the first trimester of pregnancy. If only one enantiomer is administered to a human subject, both forms may be found later in the blood serum. The drug is therefore not considered safe for use by women of child-bearing age, and while it has other uses, its use is tightly controlled. Thalidomide can be used to treat multiple myeloma.
Another commonly used drug is ibuprofen which is only anti-inflammatory as one enantiomer while the other is biologically inert. Likewise, the (S) stereoisomer is much more reactive than the (R) enantiomer in citalopram (Celexa), an antidepressant which inhibits serotonin reuptake, is active. The configurational stability of a drug is therefore an area of interest in pharmaceutical research. The production and analysis of enantiomers in the pharmaceutical industry is studied in the field of chiral organic synthesis. | 0 | Theoretical and Fundamental Chemistry |
The 2016 ExoMars Trace Gas Orbiter (TGO) is a Mars telecommunications orbiter and atmospheric gas analyzer mission. It delivered the Schiaparelli EDM lander and then began to settle into its science orbit to map the sources of methane on Mars and other gases, and in doing so, will help select the landing site for the Rosalind Franklin rover to be launched in 2022. The primary objective of the Rosalind Franklin rover mission is the search for biosignatures on the surface and subsurface by using a drill able to collect samples down to a depth of , away from the destructive radiation that bathes the surface. | 1 | Applied and Interdisciplinary Chemistry |
Preparation of McIlvaine buffer requires disodium phosphate and citric acid. One liter of 0.2M stock solution of disodium hydroxyphosphate can be prepared by dissolving 28.38g of disodium phosphate in water, and adding a quantity of water sufficient to make one liter. One liter of 0.1M stock solution of citric acid can be prepared by dissolving 19.21g of citric acid in water, and adding a quantity of water sufficient to make one liter. From these stock solutions, McIlvaine buffer can be prepared in accordance with the following table: | 1 | Applied and Interdisciplinary Chemistry |
Baker's yeast (BY) has been utilized for the kinetic resolution of α-stereogenic carbonyl compounds. The enzyme selectively reduces one enantiomer, yielding a highly enantioenriched alcohol and ketone, as shown below.
Bakers yeast has also been used in the kinetic resolution of secondary benzylic alcohols by oxidation. While excellent ees of the recovered alcohol have been reported, they typically require >60% conversion, resulting in diminished yields. Bakers yeast has also been used in the kinetic resolution via reduction of β-ketoesters. However, given the success of Noyoris resolution of the same substrates, detailed later in this article, this has not seen much use. | 0 | Theoretical and Fundamental Chemistry |
The liver contains metabolic active tissues as it is responsible for detoxification, protein and carbohydrate metabolism. Therefore, It needs a lot of energy to function and contains abundant mitochondria. Any abnormalities in mitochondria would affect liver metabolism. If the liver does not work properly, it may produce excess metabolites, leading to accumulation; in contrast, it may also fail to produce certain chemicals. As a result, the imbalance of metabolites may lead to liver cancer development, i.e. hepatocarcinogenesis. | 1 | Applied and Interdisciplinary Chemistry |
QR has many uses as a fluorescent probe. The use of QR as a probe is relatively safe, inexpensive, and a sensitive method compared with other fluorescence probes like ethidium bromide or dimeric cyanine dyes. QR is also an ideal fluorescent probe because substrates of interest, such as antibodies, can be detected within a 0.3nM detection limit without the use of radiolabeled or fluorescently labeled oligonucleotides, which are the DNA components. In other words, quinaldine red is preferred tag since its binding increases the fluorescence without extra tags being needed.
The dye's ability to bind to proteins makes it a great tag. Once bound to a protein, fluorescent signals are emitted which allow the strength of QR binding to the protein to be determined. Using this technique allows for many dynamic interactions to be understood. Another variation to detecting the QR probes is by measuring the fluorescence via a spectrofluorometer. This allows the concentration of the QR-substance (could be a protein or nucleic acids) to be measured. This also indirectly allows the binding ability of QR to the substance to be measured. Using this technique gives an emission wavelength of 520/160 nm.
QR's ability to bind to substrates and fluoresce can be further utilized to determine the location of a substrate with the use of Raman spectroscopy and the electronic absorption spectra. For example, when a cell is not energized, a cell will not take up QR. When a cell is energized, aggregations of red substrate can be found within a cell, and this can be detected with Raman spectroscopy
In addition to being used as a fluorescent probe, QR can also be used as an agent in bleaching. When exposed to intensive rays such as X-rays, gamma rays, and electron beams, the dye is able to photobleach a substance. In the case of dental bleaching, a laser is the source of intensive rays. QR is dissolved in a mixture of water, ethanol, isopropyl alcohol, glycerol, and other solvents and is placed on the teeth. In the presence of oxygen, the QR and carrier particles solution uses its sensitivity to light energy to ultimately bleach teeth, making them whiter.
Quinaldine red is also used as an indicator in experiments. In an assay for inorganic and organic phosphates, QR proved to be a better indicator due to a low blank and its color stability. When being used as an indicator, a color change is involved in order to indicate a change in the pH. For example, in a solution containing inorganic phosphate and ammonium molybdate in sulfuric acid, a reaction could occur where the two substances react forming a phosphomolybdate complex ion, or no reaction could occur. In this case, if pale pink mixture of quinaldine red turns to a colorless solution, this indicates the presence of a free phosphate. If the solution turns a dark red, that indicates the phosphomolybdate complex ion has formed. By using QR as an indicator in this manner, enzymatic activities can be monitored. | 0 | Theoretical and Fundamental Chemistry |
The drinking bird is a heat engine that exploits a temperature difference to convert heat energy to a pressure difference within the device, and performs mechanical work. Like all heat engines, the drinking bird works through a thermodynamic cycle. The initial state of the system is a bird with a wet head oriented vertically.
The process operates as follows:
# The water evaporates from the felt on the head.
# Evaporation lowers the temperature of the glass head (heat of vaporization).
# The temperature decrease causes some of the dichloromethane vapor in the head to condense.
# The lower temperature and condensation together cause the pressure to drop in the head (governed by Equations of state).
# The higher vapor pressure in the warmer base pushes the liquid up the neck.
# As the liquid rises, the bird becomes top heavy and tips over.
# When the bird tips over, the bottom end of the neck tube rises above the surface of the liquid in the bottom bulb.
# A bubble of warm vapor rises up the tube through this gap, displacing liquid as it goes.
# Liquid flows back to the bottom bulb (the toy is designed so that when it has tipped over the neck's tilt allows this). Pressure equalizes between top and bottom bulbs.
# The weight of the liquid in the bottom bulb restores the bird to its vertical position.
# The liquid in the bottom bulb is heated by ambient air, which is at a temperature slightly higher than the temperature of the bird's head.
If a glass of water is placed so that the beak dips into it on its descent, the bird will continue to absorb water and the cycle will continue as long as there is enough water in the glass to keep the head wet. However, the bird will continue to dip even without a source of water, as long as the head is wet, or as long as a temperature differential is maintained between the head and body. This differential can be generated without evaporative cooling in the head; for instance, a heat source directed at the bottom bulb will create a pressure differential between top and bottom that will drive the engine. The ultimate source of energy is the temperature gradient between the toy's head and base; the toy is not a perpetual motion machine. | 0 | Theoretical and Fundamental Chemistry |
Impermeable plasma is a type of thermal plasma which acts like an impermeable solid with respect to gas or cold plasma and can be physically pushed. Interaction of cold gas and thermal plasma was briefly studied by a group led by Hannes Alfvén in 1960s and 1970s for its possible applications in insulation of fusion plasma from the reactor walls. However, later it was found that the external magnetic fields in this configuration could induce kink instabilities in the plasma and subsequently lead to an unexpectedly high heat loss to the walls. In 2013, a group of materials scientists reported that they have successfully generated stable impermeable plasma with no magnetic confinement using only an ultrahigh-pressure blanket of cold gas. While spectroscopic data on the characteristics of plasma were claimed to be difficult to obtain due to the high pressure, the passive effect of plasma on synthesis of different nanostructures clearly suggested the effective confinement. They also showed that upon maintaining the impermeability for a few tens of seconds, screening of ions at the plasma-gas interface could give rise to a strong secondary mode of heating (known as viscous heating) leading to different kinetics of reactions and formation of complex nanomaterials. | 0 | Theoretical and Fundamental Chemistry |
Several cetacean species have very high mean blubber PCB concentrations likely to cause population declines and suppress population recovery. Striped dolphins, bottlenose dolphins and orcas were found to have mean levels that markedly exceeded all known marine mammal PCB toxicity thresholds. The western Mediterranean Sea and the south-west Iberian Peninsula were identified as "hotspots". | 1 | Applied and Interdisciplinary Chemistry |
* [http://hyperphysics.phy-astr.gsu.edu/hbase/optmod/lascool.html Laser Cooling] HyperPhysics
* PhysicsWorld series of articles by Chad Orzel:
** [https://physicsworld.com/a/cold-how-physicists-learned-to-manipulate-and-move-particles-with-laser-cooling/ Cold: how physicists learned to manipulate and move particles with laser cooling]
** [https://physicsworld.com/a/colder-how-physicists-beat-the-theoretical-limit-for-laser-cooling-and-laid-the-foundations-for-a-quantum-revolution/ Colder: how physicists beat the theoretical limit for laser cooling and laid the foundations for a quantum revolution]
** [https://physicsworld.com/a/coldest-how-a-letter-to-einstein-and-advances-in-laser-cooling-technology-led-physicists-to-new-quantum-states-of-matter/ Coldest: how a letter to Einstein and advances in laser-cooling technology led physicists to new quantum states of matter] | 0 | Theoretical and Fundamental Chemistry |
Gold, copper and tumbaga objects started being produced in Panama and Costa Rica between 300–500 CE. Open-molded casting with oxidation gilding and cast filigrees were in use. By 700–800 CE, small metal sculptures were common and an extensive range of gold and tumbaga ornaments constituted the usual regalia of persons of high status in Panama and Costa Rica.
The earliest specimen of metalwork from the Caribbean is a gold-alloy sheet carbon dated to 70–374 CE. Most Caribbean metallurgy has been dated to between 1200 and 1500 CE and consists of simple, small pieces such as sheets, pendants, beads and bells. These are mostly gold or a gold alloy (with copper or silver) and have been found to be largely cold hammered and sand-polished alluvial nuggets, although a few items seem to have been produced by lost wax casting. It is presumed that at least some of these items were acquired by trade from Colombia. | 1 | Applied and Interdisciplinary Chemistry |
Mitochondrial disease can manifest in many different ways whether in children or adults. Examples of mitochondrial diseases include:
* Mitochondrial myopathy
* Maternally inherited diabetes mellitus and deafness (MIDD)
** While diabetes mellitus and deafness can be found together for other reasons, at an early age this combination can be due to mitochondrial disease, as may occur in Kearns–Sayre syndrome and Pearson syndrome
* Leber's hereditary optic neuropathy (LHON)
**LHON is an eye disorder characterized by progressive loss of central vision due to degeneration of the optic nerves and retina (apparently affecting between 1 in 30,000 and 1 in 50,000 people); visual loss typically begins in young adulthood
* Leigh syndrome, subacute necrotizing encephalomyelopathy
** after normal development the disease usually begins late in the first year of life, although onset may occur in adulthood
** a rapid decline in function occurs and is marked by seizures, altered states of consciousness, dementia, ventilatory failure
* Neuropathy, ataxia, retinitis pigmentosa, and ptosis (NARP)
** progressive symptoms as described in the acronym
** dementia
* Myoneurogenic gastrointestinal encephalopathy (MNGIE)
** gastrointestinal pseudo-obstruction
** neuropathy
* MERRF syndrome
** progressive myoclonic epilepsy
** "Ragged Red Fibers" are clumps of diseased mitochondria that accumulate in the subsarcolemmal region of the muscle fiber and appear when muscle is stained with modified Gömöri trichrome stain
** short stature
** hearing loss
** lactic acidosis
** exercise intolerance
* MELAS syndrome, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes
* Mitochondrial DNA depletion syndrome
Conditions such as Friedreichs ataxia can affect the mitochondria but are not associated with mitochondrial proteins.' | 1 | Applied and Interdisciplinary Chemistry |
Elementary reaction steps with order 3 (called ternary reactions) are rare and unlikely to occur. However, overall reactions composed of several elementary steps can, of course, be of any (including non-integer) order.
Here stands for concentration in molarity (mol · L), for time, and for the reaction rate constant. The half-life of a first-order reaction is often expressed as t = 0.693/k (as ln(2)≈0.693). | 0 | Theoretical and Fundamental Chemistry |
The behaviour of fluids at the microscale can differ from "macrofluidic" behaviour in that factors such as surface tension, energy dissipation, and fluidic resistance start to dominate the system. Microfluidics studies how these behaviours change, and how they can be worked around, or exploited for new uses.
At small scales (channel size of around 100 nanometers to 500 micrometers) some interesting and sometimes unintuitive properties appear. In particular, the Reynolds number (which compares the effect of the momentum of a fluid to the effect of viscosity) can become very low. A key consequence is co-flowing fluids do not necessarily mix in the traditional sense, as flow becomes laminar rather than turbulent; molecular transport between them must often be through diffusion.
High specificity of chemical and physical properties (concentration, pH, temperature, shear force, etc.) can also be ensured resulting in more uniform reaction conditions and higher grade products in single and multi-step reactions. | 1 | Applied and Interdisciplinary Chemistry |
Schwartz's reagent is the common name for the organozirconium compound with the formula (CH)ZrHCl, sometimes called zirconocene hydrochloride or zirconocene chloride hydride, and is named after Jeffrey Schwartz, a chemistry professor at Princeton University. This metallocene is used in organic synthesis for various transformations of alkenes and alkynes. | 0 | Theoretical and Fundamental Chemistry |
Pure lisinopril powder is white to off white in color. Lisinopril is soluble in water (approximately 13 mg/L at room temperature), less soluble in methanol, and virtually insoluble in ethanol. | 0 | Theoretical and Fundamental Chemistry |
The heme-based enzyme nitrite reductase catalyzes the conversion of nitrite to ammonia. The cycle begins with reduction of an iron-nitrite complex to a metal nitrosyl complex.
The copper-containing enzyme nitrite reductase (CuNIR) catalyzes the 1-electron reduction of nitrite to nitric oxide. The proposed mechanism entails the protonation of a κ-NO-Cu(I) complex. This protonation induces cleavage of an N–O bond, giving a HO–Cu–ON center, which features a nitric oxide ligand O-bonded to Cu(II) (an isonitrosyl). | 0 | Theoretical and Fundamental Chemistry |
The mixing plenum normally combines two air streams, and includes for three sets of dampers: one for the fresh air, one for the exhaust air, and a mixing damper between the two air streams. The mix of fresh air and recirculated air can thus be adjusted to suit the needs of the building's occupants. Most systems will use motorized dampers to control the air mixing, and controlled by the building management system (BMS), or controls system. Typically as the fresh air and exhaust air dampers are driven from 0% open to 100% open, the mixing damper will in turn be driven from 100% open to 0% open, so as to always ensure a constant volume of supply and extract air. | 1 | Applied and Interdisciplinary Chemistry |
To fabricate synthetic self-cleaning surfaces, there are a variety of methods used to obtain the desired nanotopography and then characterize surface nanostructure and wettability. | 0 | Theoretical and Fundamental Chemistry |
PCR can be used to determine sex from a human DNA sample. The loci of Alu element insertion is selected, amplified and evaluated in terms of size of the fragment. The sex assay utilizes AluSTXa for the X chromosome, AluSTYa for the Y chromosome, or both AluSTXa and AluSTYa, to reduce the possibility of error to a negligible quantity. The inserted chromosome yields a large fragment when the homologous region is amplified. The males are distinguished as having two DNA amplicons present, while females have only a single amplicon. The kit adapted for carrying out the method includes a pair of primers to amplify the locus and optionally polymerase chain reaction reagents.
LCR can be used to diagnose tuberculosis. The sequence containing protein antigen B is targeted by four oligonucleotide primers—two for the sense strand, and two for the antisense strand. The primers bind adjacent to one another, forming a segment of double stranded DNA that once separated, can serve as a target for future rounds of replication. In this instance, the product can be detected via the microparticle enzyme immunoassay (MEIA). | 1 | Applied and Interdisciplinary Chemistry |
Pyrosequencing has also been used to analyze bisulfite-treated DNA without using methylation-specific PCR. Following PCR amplification of the region of interest, pyrosequencing is used to determine the bisulfite-converted sequence of specific CpG sites in the region. The ratio of C-to-T at individual sites can be determined quantitatively based on the amount of C and T incorporation during the sequence extension. The main limitation of this method is the cost of the technology. However, Pyrosequencing does well allow for extension to high-throughput screening methods.
A variant of this technique, described by Wong et al., uses allele-specific primers that incorporate single-nucleotide polymorphisms into the sequence of the sequencing primer, thus allowing for separate analysis of maternal and paternal alleles. This technique is of particular usefulness for genomic imprinting analysis. | 1 | Applied and Interdisciplinary Chemistry |
Many photocathodes require excellent vacuum conditions to function and will become "poisoned" when exposed to contaminates. Additionally, using the photocathodes in high current applications will slowly damage the compounds as they are exposed to ion back-bombardment. These effects are quantified by the lifetime of the photocathode. Cathode death is modeled as a decaying exponential as a function of either time or emitted charge. Lifetime is then the time constant of the exponential. | 0 | Theoretical and Fundamental Chemistry |
All living cells have the ability to receive and process signals that originate outside their membranes, which they do by means of proteins called receptors, often located at the cells surface imbedded in the plasma membrane. When such signals interact with a receptor, they effectively direct the cell to do something, such as dividing, dying, or allowing substances to be created, or to enter or exit the cell. A cells ability to respond to a chemical message depends on the presence of receptors tuned to that message. The more receptors a cell has that are tuned to the message, the more the cell will respond to it.
Receptors are created, or expressed, from instructions in the DNA of the cell, and they can be increased, or upregulated, when the signal is weak, or decreased, or downregulated, when it is strong. Their level can also be up or down regulated by modulation of systems that degrade receptors when they are no longer required by the cell.
Downregulation of receptors can also occur when receptors have been chronically exposed to an excessive amount of a ligand, either from endogenous mediators or from exogenous drugs. This results in ligand-induced desensitization or internalization of that receptor. This is typically seen in animal hormone receptors. Upregulation of receptors, on the other hand, can result in super-sensitized cells, especially after repeated exposure to an antagonistic drug or prolonged absence of the ligand.
Some receptor agonists may cause downregulation of their respective receptors, while most receptor antagonists temporarily upregulate their respective receptors. The disequilibrium caused by these changes often causes withdrawal when the long-term use of a drug is discontinued.
Upregulation and downregulation can also happen as a response to toxins or hormones. An example of upregulation in pregnancy is hormones that cause cells in the uterus to become more sensitive to oxytocin. | 1 | Applied and Interdisciplinary Chemistry |
Sublimation is a technique used by chemists to purify compounds. A solid is typically placed in a sublimation apparatus and heated under vacuum. Under this reduced pressure, the solid volatilizes and condenses as a purified compound on a cooled surface (cold finger), leaving a non-volatile residue of impurities behind. Once heating ceases and the vacuum is removed, the purified compound may be collected from the cooling surface.
For even higher purification efficiencies, a temperature gradient is applied, which also allows for the separation of different fractions. Typical setups use an evacuated glass tube that is heated gradually in a controlled manner. The material flow is from the hot end, where the initial material is placed, to the cold end that is connected to a pump stand. By controlling temperatures along the length of the tube, the operator can control the zones of re-condensation, with very volatile compounds being pumped out of the system completely (or caught by a separate cold trap), moderately volatile compounds re-condensing along the tube according to their different volatilities, and non-volatile compounds remaining in the hot end.
Vacuum sublimation of this type is also the method of choice for purification of organic compounds for use in the organic electronics industry, where very high purities (often > 99.99%) are needed to satisfy the standards for consumer electronics and other applications. | 0 | Theoretical and Fundamental Chemistry |
Spectroscopy measures the interaction of the molecules with electromagnetic radiation. Spectroscopy consists of many different applications such as atomic absorption spectroscopy, atomic emission spectroscopy, ultraviolet-visible spectroscopy, X-ray fluorescence spectroscopy, infrared spectroscopy, Raman spectroscopy, nuclear magnetic resonance spectroscopy, photoemission spectroscopy, Mössbauer spectroscopy, and circular dichroism spectroscopy. | 0 | Theoretical and Fundamental Chemistry |
AK1 genetic ablation decreases tolerance to metabolic stress. AK1 deficiency induces fiber-type specific variation in groups of transcripts in glycolysis and mitochondrial metabolism. This supports muscle energy metabolism. | 1 | Applied and Interdisciplinary Chemistry |
The organic compound 1,1,1-trichloroethane, also known as methyl chloroform and chlorothene, is a chloroalkane with the chemical formula CHCCl. It is an isomer of 1,1,2-trichloroethane. This colorless, sweet-smelling liquid was once produced industrially in large quantities for use as a solvent. It is regulated by the Montreal Protocol as an ozone-depleting substance and its use is being rapidly phased out. | 1 | Applied and Interdisciplinary Chemistry |
After water infiltrates the soil on an up-slope portion of a hill, the water may flow laterally through the soil, and exfiltrate (flow out of the soil) closer to a channel. This is called subsurface return flow or throughflow.
As it flows, the amount of runoff may be reduced in a number of possible ways: a small portion of it may evapotranspire; water may become temporarily stored in microtopographic depressions; and a portion of it may infiltrate as it flows overland. Any remaining surface water eventually flows into a receiving water body such as a river, lake, estuary or ocean. | 1 | Applied and Interdisciplinary Chemistry |
Cellulose, fibre starch that is indigestible to humans, and a filler in some low calorie foods, can be and is made from sawdust, as well as from other plant sources. While there is no documentation for the persistent rumor, based upon Upton Sinclairs novel The Jungle', that sawdust was used as a filler in sausage, cellulose derived from sawdust was and is used for sausage casings. Sawdust-derived cellulose has also been used as a filler in bread.
When cereals were scarce, sawdust was sometimes an ingredient in kommissbrot. Auschwitz concentration camp survivor, Dr. Miklós Nyiszli, reports in Auschwitz: A Doctors Eyewitness Account' that the subaltern medical staff, who served Dr. Josef Mengele, subsisted on "bread made from wild chestnuts sprinkled with sawdust".
Sawdust is a primary ingredient in many types of processed chicken. | 1 | Applied and Interdisciplinary Chemistry |
It is a gaseous mixture of 60-80% tetrafluoroethane (R-134a), 10-30% pentafluoroethane (R-125) and 10-30% carbon dioxide (CO).
Its physical properties are similar to those of Halon 1301. | 1 | Applied and Interdisciplinary Chemistry |
PDE enzymes are composed of 3 functional domains: an N-terminal cyclin fold domain, a linker helical domain and a C-terminal helical bundle domain (see figure 3). The active site is a deep pocket at the junction of the 3 subdomains and is lined with highly conserved residues between isotypes of PDE. The pocket is approximately 15 Å deep and the opening is approximately 20 by 10 Å. The volume of the active site has been calculated to be between 875 and 927 Å. The active site of PDE5 has been described as subdivided into 3 main regions based on its crystal structure in complex with sildenafil:
*M site: contains both a zinc and magnesium ion. The role of the ions is to stabilize the structure and activation of hydroxide to mediate the reaction. Current PDE5 inhibitors do not interact with the metal ions, in contrast with cGMP. Direct or indirect interactions may improve the potency of future inhibitors.
*Q pocket: it is believed that the guanidine group of cGMP binds in this region as the Q pocket accommodates the pyrazolopyrimidinone group (see figure 4) of sildenafil. The pyrazolopyrimidinone of sildenafil mimics that of the guanine in cGMP and has the same H-bond donor and acceptor features, forming a bidendrate H-bond with Q817. Card et al. describe the Q pocket as subdivided into 3 parts:
**A saddle formed by the conserved glutamine (Q817 in PDE5A, Q443 in PDE4B and Q369 in PDE4D) and the P clamp (a hydrophobic clamp at the narrow side of the active sites pocket, formed of invariant purine-selective glutamine and a pair of conserved residues).
**2 narrow, hydrophobic pockets, Q1 and Q2, composed mainly of hydrophobic residues flanking the saddle.
*L region: the methyl piperazine group (see figure 4) of sildenafil is surrounded by Tyr 664, Met 816, Ala 823 and Gly 819 residues, and residues 662-664 form a lid over the pocket narrowing the entrance to the active site of PDE5.
Jeon et al. also describe a fourth pocket called the H pocket which is hydrophobic and accommodates the ethoxyphenyl group of sildenafil
The 3 PDE5 inhibitors already on the market, sildenafil, tadalafil and vardenafil, occupy part of the active site, mainly around the Q pocket and sometimes the M pocket as well and all 3 interact with the active site in 3 important manners:
#interaction between the metal ions mediated through water
#hydrogen bonding with the saddle of the Q pocket
#hydrophobic interaction with hydrophobic residues lining the cavity of the active site.
It has also been described that the hydrophobic interaction with the Q1 and Q2 pockets are important for inhibitor potency and differences between isotypes of PDE in the Q2 pocket can be exploited for selectivity between isotypes. | 1 | Applied and Interdisciplinary Chemistry |
The thermo-dielectric effect is the production of electric currents and charge separation during phase transition.
This interesting effect was discovered by Joaquim da Costa Ribeiro in 1944. The Brazilian physicist observed that solidification and melting of many dielectrics are accompanied by charge separation. A thermo-dielectric effect was demonstrated with carnauba wax, naphthalene and paraffin. Charge separation in ice was also expected. This effect was observed during water freezing period, electrical storm effects can be caused by this strange phenomenon. Effect was measured by many researches - Bernhard Gross, Armando Dias Tavares, Sergio Mascarenhas etc. César Lattes (co-discoverer of the pion) supposed that this was the only effect ever to be discovered entirely in Brasil. | 0 | Theoretical and Fundamental Chemistry |
The nitrate ion can easily be identified by heating copper turnings along with concentrated sulfuric acid. Effervescence of a brown, pungent gas is observed which turns moist blue litmus paper red.
Here sulfuric acid reacts with the nitrate ion to form nitric acid. Nitric acid then reacts with the copper turnings to form nitric oxide. Nitric oxide is thus oxidised to nitrogen dioxide. | 0 | Theoretical and Fundamental Chemistry |
Early in embryonic development, the embryo has three germ layers and abuts a yolk sac. During the second week of development, the embryo grows and begins to surround and envelop portions of this sac. The enveloped portions form the basis for the adult gastrointestinal tract. Sections of this foregut begin to differentiate into the organs of the gastrointestinal tract, such as the esophagus, stomach, and intestines.
During the fourth week of development, the stomach rotates. The stomach, originally lying in the midline of the embryo, rotates so that its body is on the left. This rotation also affects the part of the gastrointestinal tube immediately below the stomach, which will go on to become the duodenum. By the end of the fourth week, the developing duodenum begins to spout a small outpouching on its right side, the hepatic diverticulum, which will go on to become the biliary tree. Just below this is a second outpouching, known as the cystic diverticulum, that will eventually develop into the gallbladder. | 1 | Applied and Interdisciplinary Chemistry |
The intense color from which the compound gets its name results from irradiation and subsequent excitation and relaxation of the extended π electron system across the R-N=N-R linked phenols. Absorption of these electrons falls in the visible region of the electromagnetic spectrum. Azo violets intense indigo color (λ 432 nm) approximates Pantone R: 102 G: 15 B: 240. | 0 | Theoretical and Fundamental Chemistry |
Concerns about the limits of worldwide uranium resources motivated initial interest in the thorium fuel cycle. It was envisioned that as uranium reserves were depleted, thorium would supplement uranium as a fertile material. However, for most countries uranium was relatively abundant and research in thorium fuel cycles waned. A notable exception was India's three-stage nuclear power programme.
In the twenty-first century thorium's claimed potential for improving proliferation resistance and waste characteristics led to renewed interest in the thorium fuel cycle. While thorium is more abundant in the continental crust than uranium and easily extracted from monazite as a side product of rare earth element mining, it is much less abundant in seawater than uranium.
At Oak Ridge National Laboratory in the 1960s, the Molten-Salt Reactor Experiment used as the fissile fuel in an experiment to demonstrate a part of the Molten Salt Breeder Reactor that was designed to operate on the thorium fuel cycle. Molten salt reactor (MSR) experiments assessed thorium's feasibility, using thorium(IV) fluoride dissolved in a molten salt fluid that eliminated the need to fabricate fuel elements. The MSR program was defunded in 1976 after its patron Alvin Weinberg was fired.
In 1993, Carlo Rubbia proposed the concept of an energy amplifier or "accelerator driven system" (ADS), which he saw as a novel and safe way to produce nuclear energy that exploited existing accelerator technologies. Rubbia's proposal offered the potential to incinerate high-activity nuclear waste and produce energy from natural thorium and depleted uranium.
Kirk Sorensen, former NASA scientist and Chief Technologist at Flibe Energy, has been a long-time promoter of thorium fuel cycle and particularly liquid fluoride thorium reactors (LFTRs). He first researched thorium reactors while working at NASA, while evaluating power plant designs suitable for lunar colonies. In 2006 Sorensen started "energyfromthorium.com" to promote and make information available about this technology.
A 2011 MIT study concluded that although there is little in the way of barriers to a thorium fuel cycle, with current or near term light-water reactor designs there is also little incentive for any significant market penetration to occur. As such they conclude there is little chance of thorium cycles replacing conventional uranium cycles in the current nuclear power market, despite the potential benefits. | 0 | Theoretical and Fundamental Chemistry |
In thermal fluid dynamics, the Nusselt number (, after Wilhelm Nusselt) is the ratio of total heat transfer to conductive heat transfer at a boundary in a fluid. Total heat transfer combines conduction and convection. Convection includes both advection (fluid motion) and diffusion (conduction). The conductive component is measured under the same conditions as the convective but for a hypothetically motionless fluid. It is a dimensionless number, closely related to the fluid's Rayleigh number.
A Nusselt number of order one represents heat transfer by pure conduction. A value between one and 10 is characteristic of slug flow or laminar flow. A larger Nusselt number corresponds to more active convection, with turbulent flow typically in the 100–1000 range.
A similar non-dimensional property is the Biot number, which concerns thermal conductivity for a solid body rather than a fluid. The mass transfer analogue of the Nusselt number is the Sherwood number. | 1 | Applied and Interdisciplinary Chemistry |
In the old days of traditional manufacturing, steel and other metals arrived at factories in an untreated and unpainted state. Companies would fabricate and paint or treat the metal components of their product before assembly. This was costly, time-consuming, and environmentally harmful. The coil coating process was pioneered in the 1930s for painting, coating and pre-treating large coils of metals before they arrived at a manufacturing facility. The venetian blind industry was the first to utilize pre-painted metal. | 1 | Applied and Interdisciplinary Chemistry |
When tides enter estuaries or basins, the boundary conditions change as the geometry changes drastically. The water depth becomes shallower and the width decreases, next to that the depth and width become significantly variable over the length and width of the estuary or basin. As a result the tidal wave deforms which affects the tidal amplitude, phase speed and the relative phase between tidal velocity and elevation. The deformation of the tide is largely controlled by the competition between bottom friction and channel convergence. Channel convergence increases the tidal amplitude and phase speed as the energy of the tidal wave is traveling through a smaller area while bottom friction decrease the amplitude through energy loss. The modification of the tide leads to the creation of overtides (e.g. tidal constituents) or higher harmonics. These overtides are multiples, sums or differences of the astronomical tidal constituents and as a result the tidal wave can become asymmetric. A tidal asymmetry is a difference between the duration of the rise and the fall of the tidal water elevation and this can manifest itself as a difference in flood/ebb tidal currents. The tidal asymmetry and the resulting currents are important for the sediment transport and turbidity in estuaries and tidal basins. Each estuary and basin has its own distinct geometry and these can be subdivided in several groups of similar geometries with its own tidal dynamics. | 1 | Applied and Interdisciplinary Chemistry |
The deprotonation of carbon acids can proceed with either kinetic or thermodynamic reaction control. Kinetic controlled deprotonation requires a base that is sterically hindered and strong enough to remove the proton irreversibly. For example, in the case of phenylacetone, deprotonation can produce two different enolates. LDA has been shown to deprotonate the methyl group, which is the kinetic course of the deprotonation. To ensure the production of the kinetic product, a slight excess (1.1 equiv) of lithium diisopropylamide is used, and the ketone is added to the base at –78 °C. Because the ketone is quickly and quantitatively converted to the enolate and base is present in excess at all times, the ketone is unable to act as a proton shuttle to catalyze the gradual formation of the thermodynamic product. A weaker base such as an alkoxide, which reversibly deprotonates the substrate, affords the more thermodynamically stable benzylic enolate. An alternative to the weaker base is to use a strong base which is present at a lower concentration than the ketone. For instance, with a slurry of sodium hydride in THF or dimethylformamide (DMF), the base only reacts at the solution-solid interface. A ketone molecule might be deprotonated at the kinetic site. This enolate may then encounter other ketones and the thermodynamic enolate will form through the exchange of protons, even in an aprotic solvent which does not contain hydronium ions.
LDA can, however, act as a nucleophile under certain conditions. | 0 | Theoretical and Fundamental Chemistry |
Analysis of amplicons has been made possible by the development of amplification methods such as PCR, and increasingly by cheaper and more high-throughput technologies for DNA sequencing or next-generation sequencing, such as ion semiconductor sequencing, popularly referred to as the brand of the developer, Ion Torrent.
DNA sequencing technologies such as next-generation sequencing have made it possible to study amplicons in genome biology and genetics, including cancer genetics research, phylogenetic research, and human genetics. For example, using the 16S rRNA gene, which is part of every bacterial and archaeal genome and is highly conserved, bacteria can be taxonomically classified by comparison of the amplicon sequence to known sequences. This works similarly in the fungal domain with the 18S rRNA gene as well as the ITS1 non-coding region.
Irrespective of the approach used to amplify the amplicons, some technique must be used to quantitate the amplified product. Generally, these techniques incorporate a capture step and a detection step, although how these steps are incorporated depends on the individual assay.
Examples include the Amplicor HIV-1 Monitor Assay (RT-PCR), which has the capacity to recognize HIV in plasma; the HIV-1 QT (NASBA), which is used to measure plasma viral load by amplifying a segment of the HIV RNA; and transcription mediated amplification, which employs a hybridization protection assay to distinguish Chlamydia trachomatis infections. Various detection and capture steps are involved in each approach to assess the amplification product, or amplicon. With amplicon sequencing the high number of different amplicons resulting from amplification of a usual sample are concatenated and sequenced. After quality control classification is done by different methods, the counts of identical taxa representing their relative abundance in the sample. | 1 | Applied and Interdisciplinary Chemistry |
Rational thermodynamics is a school of thought in statistical thermodynamics developed in the 1960s.
Its introduction is attributed to Clifford Truesdell (1919–2000), Bernard Coleman (b. 1929) and Walter Noll (1925–2017).
The aim was to develop a mathematical model of thermodynamics that would go beyond the traditional "thermodynamics of irreversible processes" or TIP developed in the late 19th to early 20th centuries.
Truesdell's "flamboyant style" and "satirical verve" caused controversy between "rational thermodynamics" and proponents of traditional thermodynamics. | 0 | Theoretical and Fundamental Chemistry |
The multiplication factor, , is defined as (see nuclear chain reaction):
* If is greater than 1, the chain reaction is supercritical, and the neutron population will grow exponentially.
* If is less than 1, the chain reaction is subcritical, and the neutron population will exponentially decay.
* If , the chain reaction is critical and the neutron population will remain constant. | 0 | Theoretical and Fundamental Chemistry |
Bioremediation of radioactive waste or bioremediation of radionuclides is an application of bioremediation based on the use of biological agents bacteria, plants and fungi (natural or genetically modified) to catalyze chemical reactions that allow the decontamination of sites affected by radionuclides. These radioactive particles are by-products generated as a result of activities related to nuclear energy and constitute a pollution and a radiotoxicity problem (with serious health and ecological consequences) due to its unstable nature of ionizing radiation emissions.
The techniques of bioremediation of environmental areas as soil, water and sediments contaminated by radionuclides are diverse and currently being set up as an ecological and economic alternative to traditional procedures. Physico-chemical conventional strategies are based on the extraction of waste by excavating and drilling, with a subsequent long-range transport for their final confinement. These works and transport have often unacceptable estimated costs of operation that could exceed a trillion dollars in the US and 50 million pounds in the UK.
The species involved in these processes have the ability to influence the properties of radionuclides such as solubility, bioavailability and mobility to accelerate its stabilization. Its action is largely influenced by electron donors and acceptors, nutrient medium, complexation of radioactive particles with the material and environmental factors. These are measures that can be performed on the source of contamination (in situ) or in controlled and limited facilities in order to follow the biological process more accurately and combine it with other systems (ex situ). | 1 | Applied and Interdisciplinary Chemistry |
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists – and hence, monoaminergic neuromodulators – that are structurally and metabolically related to classical monoamine neurotransmitters. Compared to the classical monoamines, they are present in trace concentrations. They are distributed heterogeneously throughout the mammalian brain and peripheral nervous tissues and exhibit high rates of metabolism. Although they can be synthesized within parent monoamine neurotransmitter systems, there is evidence that suggests that some of them may comprise their own independent neurotransmitter systems.
Trace amines play significant roles in regulating the quantity of monoamine neurotransmitters in the synaptic cleft of monoamine neurons with . They have well-characterized presynaptic amphetamine-like effects on these monoamine neurons via TAAR1 activation; specifically, by activating TAAR1 in neurons they promote the release and prevent reuptake of monoamine neurotransmitters from the synaptic cleft as well as inhibit neuronal firing. Phenethylamine and amphetamine possess analogous pharmacodynamics in human dopamine neurons, as both compounds induce efflux from vesicular monoamine transporter 2 (VMAT2) and activate TAAR1 with comparable efficacy.
Like dopamine, norepinephrine, and serotonin, the trace amines have been implicated in a vast array of human disorders of affect and cognition, such as ADHD, depression and schizophrenia, among others. Trace aminergic hypo-function is particularly relevant to ADHD, since urinary and plasma phenethylamine concentrations are significantly lower in individuals with ADHD relative to controls and the two most commonly prescribed drugs for ADHD, amphetamine and methylphenidate, increase phenethylamine biosynthesis in treatment-responsive individuals with ADHD. A systematic review of ADHD biomarkers also indicated that urinary phenethylamine levels could be a diagnostic biomarker for ADHD. | 1 | Applied and Interdisciplinary Chemistry |
Because it measures anti-oxidant capacity in vitro, the reagent has been used to assay foods and supplements in food science. The oxygen radical absorbance capacity (ORAC) used to be the industry standard for antioxidant strength of whole foods, juices and food additives. Earlier measurements and ratings by the United States Department of Agriculture were withdrawn in 2012 as biologically irrelevant to human health, referring to an absence of physiological evidence for polyphenols having antioxidant properties in vivo. Consequently, the ORAC method, derived only from in vitro experiments, is no longer considered relevant to human diets or biology.
The Trolox equivalent antioxidant capacity assay – also based on the presence of polyphenols – is an alternative in vitro measurements of antioxidant capacity. | 0 | Theoretical and Fundamental Chemistry |
The slippery sequence for a +1 frameshift signal does not have the same motif, and instead appears to function by pausing the ribosome at a sequence encoding a rare amino acid. Ribosomes do not translate proteins at a steady rate, regardless of the sequence. Certain codons take longer to translate, because there are not equal amounts of tRNA of that particular codon in the cytosol. Due to this lag, there exist in small sections of codons sequences that control the rate of ribosomal frameshifting. Specifically, the ribosome must pause to wait for the arrival of a rare tRNA, and this increases the kinetic favorability of the ribosome and its associated tRNA slipping into the new frame. In this model, the change in reading frame is caused by a single tRNA slip rather than two. | 1 | Applied and Interdisciplinary Chemistry |
In 2020, the monoclonal antibody therapies bamlanivimab/etesevimab and casirivimab/imdevimab were given emergency use authorizations by the US Food and Drug Administration to reduce the number of hospitalizations, emergency room visits, and deaths. In September 2021, the Biden administration purchased billion worth of Regeneron monoclonal antibodies at $2,100 per dose to curb the shortage.
As of December 2021, in vitro neutralization tests indicate monoclonal antibody therapies (with the exception of sotrovimab and tixagevimab/cilgavimab) were not likely to be active against the Omicron variant.
Over 2021–22, two Cochrane reviews found insufficient evidence for using neutralizing monoclonal antibodies to treat COVID-19 infections. The reviews applied only to people who were unvaccinated against COVID‐19, and only to the COVID-19 variants existing during the studies, not to newer variants, such as Omicron.
In March 2024, pemivibart, a monoclonal antibody drug, received an emergency use authorization from the US FDA for use as pre-exposure prophylaxis to protect certain moderately to severely immunocompromised individuals against COVID-19. | 1 | Applied and Interdisciplinary Chemistry |
Tens of oligonucleotide probes are designed to be complementary to the RNA of interest. These oligos are labeled with biotin. Cells are cross-linked by UV or formalin and nuclei are isolated from these treated cells. The isolated nuclei were lysed and the released chromatin was fragmented by sonication to produce approximately 100-500 bp sized fragments. These chromatin fragments were hybridized to the biotinylated probe set. Complexes containing biotin-probe + RNA of interest + DNA fragment are captured by magnetic beads labeled with streptavidin.
DNA is isolated from an aliquot of the bound complex by treatment with RNAse (or proteinase followed by RNAse) to digest associated protein and RNA. RNA may also be isolated from an additional aliquot of the bound complex to detect other RNA molecules associated with the RNA of interest. The purified DNA is then used to prepare a sequencing library and the library is sequenced on a next generation DNA sequencing system. The sequencing reads are then mapped to the genome. A pile-up of reads at specific locations on the genome indicates that the RNA of interest had bound to that region of the genome. This helps delineate specific genomic regions that interact with RNA. For example, genomic targets of enhancer RNA which act at a distance from their site of synthesis can be easily evaluated by ChiRP-Seq. | 1 | Applied and Interdisciplinary Chemistry |
* Glycoglycerolipids: a sub-group of glycolipids characterized by an acetylated or non-acetylated glycerol with at least one fatty acid as the lipid complex. Glyceroglycolipids are often associated with photosynthetic membranes and their functions. The subcategories of glyceroglycolipids depend on the carbohydrate attached.
** Galactolipids: defined by a galactose sugar attached to a glycerol lipid molecule. They are found in chloroplast membranes and are associated with photosynthetic properties.
** Sulfolipids: have a sulfur-containing functional group in the sugar moiety attached to a lipid. An important group is the sulfoquinovosyl diacylglycerols which are associated with the sulfur cycle in plants.
* Glycosphingolipids: a sub-group of glycolipids based on sphingolipids. Glycosphingolipids are mostly located in nervous tissue and are responsible for cell signaling.
** Cerebrosides: a group glycosphingolipids involved in nerve cell membranes.
*** Galactocerebrosides: a type of cerebroseide with galactose as the saccharide moiety
*** Glucocerebrosides: a type of cerebroside with glucose as the saccharide moiety; often found in non-neural tissue.
*** Sulfatides: a class of glycolipids containing a sulfate group in the carbohydrate with a ceramide lipid backbone. They are involved in numerous biological functions ranging from immune response to nervous system signaling.
** Gangliosides: the most complex animal glycolipids. They contain negatively charged oligosacchrides with one or more sialic acid residues; more than 200 different gangliosides have been identified. They are most abundant in nerve cells.
** Globosides: glycosphingolipids with more than one sugar as part of the carbohydrate complex. They have a variety of functions; failure to degrade these molecules leads to Fabry disease.
** Glycophosphosphingolipids: complex glycophospholipids from fungi, yeasts, and plants, where they were originally called "phytoglycolipids". They may be as complicated a set of compounds as the negatively charged gangliosides in animals.
** Glycophosphatidylinositols: a sub-group of glycolipids defined by a phosphatidylinositol lipid moiety bound to a carbohydrate complex. They can be bound to the C-terminus of a protein and have various functions associated with the different proteins they can be bound to.
* Saccharolipids | 0 | Theoretical and Fundamental Chemistry |
Pomeroys report contains errors in the equation: the pipeline slope (S, p. 8) is quoted as m/100m, but should be m/m. This introduces a factor of 10 underestimate in the calculation of the Z factor', used to indicate if there is a risk of sulphide-induced corrosion, if the published units are used. The web link is to the revised 1992 edition, which contains the units error - the 1976 edition has the correct units. | 1 | Applied and Interdisciplinary Chemistry |
A hydrogel is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. A three-dimensional solid results from the hydrophilic polymer chains being held together by cross-links. Because of the inherent cross-links, the structural integrity of the hydrogel network does not dissolve from the high concentration of water. Hydrogels are highly absorbent (they can contain over 90% water) natural or synthetic polymeric networks.
Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content. As responsive "smart materials," hydrogels can encapsulate chemical systems which upon stimulation by external factors such as a change of pH may cause specific compounds such as glucose to be liberated to the environment, in most cases by a gel-sol transition to the liquid state. Chemomechanical polymers are mostly also hydrogels, which upon stimulation change their volume and can serve as actuators or sensors. The first appearance of the term hydrogel in the literature was in 1894. | 0 | Theoretical and Fundamental Chemistry |
GEOMAR operates two open ocean research vessels: the 36-year-old RV Poseidon (1050 GT) and the 20-year-old RV Alkor (1000 GT). In 2009, both vessels were refurbished and modernised. It also operates the research cutter, RC Littorina (168 GT) and the research boat, RB Polarfuchs (16 GT). In addition it operates JAGO, a three-ton research submersible, the only manned research submersible in Germany, capable of diving to 400 metres, as well as a remotely operated underwater vehicle, ROV KIEL 6000 capable of diving to 6,000 metres, an autonomous underwater vehicle, AUV ABYSS, and a video-controlled hydraulic grab, TV-Grab. At the end of 2010, the institute took possession of ROV PHOCA, a new 1.5 ton ROV with an operational working depth of 3000 metres. | 0 | Theoretical and Fundamental Chemistry |
As a historian of science, Brown contributed seven biographical profiles of African American chemists to the African American National Biography Project, of which contained the first African American women to get their Ph.Ds degrees in chemistry and chemical engineering. She is the author of the 2011 book African American Women Chemists, which profiles early African American women in chemistry. Her second book African American Women Chemists in the Modern Era' focuses on contemporary women who have benefited from the Civil Rights Act and are now working as chemists or chemical engineers. | 1 | Applied and Interdisciplinary Chemistry |
Shock is formed due to coalescence of various small pressure pulses. Sound waves are pressure waves and it is at the speed of the sound wave the disturbances are communicated in the medium. When an object is moving in a flow field the object sends out disturbances which propagate at the speed of sound and adjusts the remaining flow field accordingly. However, if the object itself happens to travel at speed greater than sound, then the disturbances created by the object would not have traveled and communicated to the rest of the flow field and this results in an abrupt change of property, which is termed as shock in gas dynamics terminology.
Shocks are characterized by discontinuous changes in flow properties such as velocity, pressure, temperature, etc. Typically, shock thickness is of a few mean free paths (of the order of 10 m). Shocks are irreversible occurrences in supersonic flows (i.e. the entropy increases). | 1 | Applied and Interdisciplinary Chemistry |
Because the kinetic energy of the emitted electrons is exactly the energy of the incident photon minus the energy of the electron's binding within an atom, molecule or solid, the binding energy can be determined by shining a monochromatic X-ray or UV light of a known energy and measuring the kinetic energies of the photoelectrons. The distribution of electron energies is valuable for studying quantum properties of these systems. It can also be used to determine the elemental composition of the samples. For solids, the kinetic energy and emission angle distribution of the photoelectrons is measured for the complete determination of the electronic band structure in terms of the allowed binding energies and momenta of the electrons. Modern instruments for angle-resolved photoemission spectroscopy are capable of measuring these quantities with a precision better than 1 meV and 0.1°.
Photoelectron spectroscopy measurements are usually performed in a high-vacuum environment, because the electrons would be scattered by gas molecules if they were present. However, some companies are now selling products that allow photoemission in air. The light source can be a laser, a discharge tube, or a synchrotron radiation source.
The concentric hemispherical analyzer is a typical electron energy analyzer. It uses an electric field between two hemispheres to change (disperse) the trajectories of incident electrons depending on their kinetic energies. | 0 | Theoretical and Fundamental Chemistry |
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures, which in turn is central to evolutionary developmental biology (evo-devo).
The regulator can be DNA, RNA, protein or any combination of two or more of these three that form a complex, such as a specific sequence of DNA and a transcription factor to activate that sequence. The interaction can be direct or indirect (through transcribed RNA or translated protein). In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases the protein will be an enzyme, i.e., a micro-machine that catalyses a certain reaction, such as the breakdown of a food source or toxin. Some proteins though serve only to activate other genes, and these are the transcription factors that are the main players in regulatory networks or cascades. By binding to the promoter region at the start of other genes they turn them on, initiating the production of another protein, and so on. Some transcription factors are inhibitory.
In single-celled organisms, regulatory networks respond to the external environment, optimising the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to alcohol. This process, which we associate with wine-making, is how the yeast cell makes its living, gaining energy to multiply, which under normal circumstances would enhance its survival prospects.
In multicellular animals the same principle has been put in the service of gene cascades that control body-shape. Each time a cell divides, two cells result which, although they contain the same genome in full, can differ in which genes are turned on and making proteins. Sometimes a self-sustaining feedback loop ensures that a cell maintains its identity and passes it on. Less understood is the mechanism of epigenetics by which chromatin modification may provide cellular memory by blocking or allowing transcription. A major feature of multicellular animals is the use of morphogen gradients, which in effect provide a positioning system that tells a cell where in the body it is, and hence what sort of cell to become. A gene that is turned on in one cell may make a product that leaves the cell and diffuses through adjacent cells, entering them and turning on genes only when it is present above a certain threshold level. These cells are thus induced into a new fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal transduction. Such signalling controls embryogenesis, the building of a body plan from scratch through a series of sequential steps. They also control and maintain adult bodies through feedback processes, and the loss of such feedback because of a mutation can be responsible for the cell proliferation that is seen in cancer. In parallel with this process of building structure, the gene cascade turns on genes that make structural proteins that give each cell the physical properties it needs. | 1 | Applied and Interdisciplinary Chemistry |
Electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-Q oxidoreductase), also known as electron transferring-flavoprotein dehydrogenase, is a third entry point to the electron transport chain. It is an enzyme that accepts electrons from electron-transferring flavoprotein in the mitochondrial matrix, and uses these electrons to reduce ubiquinone. This enzyme contains a flavin and a [4Fe–4S] cluster, but, unlike the other respiratory complexes, it attaches to the surface of the membrane and does not cross the lipid bilayer.
In mammals, this metabolic pathway is important in beta oxidation of fatty acids and catabolism of amino acids and choline, as it accepts electrons from multiple acetyl-CoA dehydrogenases. In plants, ETF-Q oxidoreductase is also important in the metabolic responses that allow survival in extended periods of darkness. | 1 | Applied and Interdisciplinary Chemistry |
R-M systems are major players in the co-evolutionary interaction between mobile genetic elements (MGEs) and their hosts. Genes encoding R-M systems have been reported to move between prokaryotic genomes within MGEs such as plasmids, prophages, insertion sequences/transposons, integrative conjugative elements (ICEs) and integrons. However, it was recently found that there are relatively few R-M systems in plasmids, some in prophages, and practically none in phages. On the other hand, all these MGEs encode a large number of solitary R-M genes, notably MTases. In light of this, it is likely that R-M mobility may be less dependent on MGEs and more dependent, for example, on the existence of small genomic integration hotspots. It is also possible that R-M systems frequently exploit other mechanisms such as natural transformation, vesicles, nanotubes, gene transfer agents or generalized transduction in order to move between genomes. | 1 | Applied and Interdisciplinary Chemistry |
Digestion of some fats can begin in the mouth where lingual lipase breaks down some short chain lipids into diglycerides. However fats are mainly digested in the small intestine. The presence of fat in the small intestine produces hormones that stimulate the release of pancreatic lipase from the pancreas and bile from the liver which helps in the emulsification of fats for absorption of fatty acids. Complete digestion of one molecule of fat (a triglyceride) results a mixture of fatty acids, mono- and di-glycerides, but no glycerol. | 1 | Applied and Interdisciplinary Chemistry |
CYC1 is a human gene that is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C. elegans, S. cerevisiae, K. lactis, E. gossypii, S. pombe, N. crassa, A. thaliana, rice, and frog. There are orthologs of CYC1 in 137 known organisms.
In its structure and function, the cytochrome b-c1 complex bears extensive analogy to the cytochrome b6f complex of chloroplasts and cyanobacteria; cytochrome c1 plays an analogous role to cytochrome f, despite their different structures. | 1 | Applied and Interdisciplinary Chemistry |
Mestizo communities in Loreto, Peru use peatlands for hunting and gathering, and sustainably cultivating native palms, which they replant to restore the resource. They are conscious of the limits to the resource and the need to avoid wasteful felling during harvest. | 1 | Applied and Interdisciplinary Chemistry |
A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily be a linear relationship between the two values. In contrast to this article's previous definition of the Hill equation, the IUPHAR defines the Hill equation in terms of the tissue response , as
where is the drug concentration, is the Hill coefficient, and is the drug concentration that produces a 50% maximal response. Dissociation constants (in the previous section) relate to ligand binding, while reflects tissue response.
This form of the equation can reflect tissue/cell/population responses to drugs and can be used to generate dose response curves. The relationship between and EC50 may be quite complex as a biological response will be the sum of myriad factors; a drug will have a different biological effect if more receptors are present, regardless of its affinity.
The Del-Castillo Katz model is used to relate the Hill equation to receptor activation by including a second equilibrium of the ligand-bound receptor to an activated form of the ligand-bound receptor.
Statistical analysis of response as a function of stimulus may be performed by regression methods such as the probit model or logit model, or other methods such as the Spearman–Kärber method. Empirical models based on nonlinear regression are usually preferred over the use of some transformation of the data that linearizes the dose-response relationship. | 1 | Applied and Interdisciplinary Chemistry |
Teeth are complex structures made of materials specific to them. They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body—enamel. Teeth have different shapes to deal with different aspects of mastication employed in tearing and chewing pieces of food into smaller and smaller pieces. This results in a much larger surface area for the action of digestive enzymes.
The teeth are named after their particular roles in the process of mastication—incisors are used for cutting or biting off pieces of food; canines, are used for tearing, premolars and molars are used for chewing and grinding. Mastication of the food with the help of saliva and mucus results in the formation of a soft bolus which can then be swallowed to make its way down the upper gastrointestinal tract to the stomach.
The digestive enzymes in saliva also help in keeping the teeth clean by breaking down any lodged food particles. | 1 | Applied and Interdisciplinary Chemistry |
Wilhem Walter Rudolph Max Seelmann-Eggebert (17 April 1915 – 19 July 1988) was a German radiochemist. He was son of Erich Eggebert and Edwig Schmidt.
He was a student of Otto Hahn at the Kaiser Wilhelm Institute for Chemistry, where, after 1939, he worked with Fritz Strassmann on nuclear fission.
In 1949, he joined the University of Tucuman in Argentina as a professor of chemistry. Later he created the radiochemistry group at the Buenos Aires University and at the National Atomic Energy Commission, working together with other notable pioneers of radiochemistry, such as Sara Abecasis, Gregorio Baro, Juan Flegenheimer, Jaime Pahissa-Campá, María Cristina Palcos, Enzo Ricci, Renato Radicella, Plinio Rey, Josefina Rodríguez, and Maela Viirsoo, just to mention a few. During his Argentinian years his group discovered 20 new nuclides.
In 1955, Otto Hahn invited him to come back to Germany for the reconstruction of radiochemistry studies in the country. He became professor in Mainz before creating and managing the Radiochemistry Institute from the Karlsruhe Kernforschungszentrum, now the Karlsruhe Institute of Technology (KIT).
In 1958, together with Gerda Pfennig, he edited the first "Karlsruher Nuklidkarte" which has become a basic element both for nuclear scientists and education. | 0 | Theoretical and Fundamental Chemistry |
tert-Butanesulfinamide (also known as 2-methyl-2-propanesulfinamide or Ellmans sulfinamide) is an organosulfur compound and a member of the class of sulfinamides. Both enantiomeric forms are commercially available and are used in asymmetric synthesis as chiral auxiliaries, often as chiral ammonia equivalents for the synthesis of amines. tert-Butanesulfinamide and the associated synthetic methodology was introduced in 1997 by Jonathan A. Ellman et al'. | 0 | Theoretical and Fundamental Chemistry |
* Khwarizmi International Award,
* Distinguished National Professor, 1997,
* The first-class Research Medal, University of Tehran, 2003,
* National Eminent Character 2003,
* First-rank basic science research medal in Annual Razi Medical Sciences Research Festival 2005,
*Iranian Science and Culture Hall of Fame, 2005
* Top Researcher Elsevier-Scopus International Award in the field of Biochemistry, Genetics & Molecular Biology, 2007,
* First Rank Avicenna Festival Award as Top Researcher 2008,
* Member of Academy of Sciences of Iran, 2009,
* National eminent researcher first- rank award conferred in National Research Festival by Ministry of Science, Research and Technology of Iran, 2009,
*Chosen as Eminent Professor of University of Tehran 2010,
* distinguished Professor appointed by Iran's National Elites Foundation 2012,
* Essential Science Indicators (ESI) 1% citation scientist in the field of Biology and Biochemistry since 2013,
* TWAS (The World Academy of Sciences) Fellow 2015,
* IAS (The Islamic Academy of Sciences) Fellow 2016
* COMSTECH Award for Lifetime Achievement Award in Chemistry 2021 | 0 | Theoretical and Fundamental Chemistry |
While Hahn was in North America, his attention was drawn to a mica-like mineral from Manitoba that contained rubidium. Some years before he had studied the radioactive decay of rubidium-87, and had estimated its half life at 2 x 10 years. It occurred to Hahn that by comparing the quantity of strontium in the mineral (which had once been rubidium) with that of the remaining rubidium, he could measure the age of the mineral, assuming that his original calculation of the half life was reasonably accurate. This would be a superior dating method to studying the decay of uranium, because some of the uranium turns into helium, which then escapes, resulting in rocks appearing to be younger than they really were. Jacob Papish helped Hahn obtain several kilograms of the mineral.
From 1,012 grams of the mineral, Strassmann and Ernst Walling extracted 253.4 milligrams of strontium carbonate, all of which was the strontium-87 isotope, indicating that it had all been produced from radioactive decay of rubidium-87. The age of the mineral had been estimated at 1,975 million years from uranium minerals in the same deposit, which implied that the half life of rubidium-87 was 2.3 x 10 years: quite close to Hahn's original calculation. Rubidium–strontium dating became a widely used technique for dating rocks in the 1950s, when mass spectrometry became common. | 0 | Theoretical and Fundamental Chemistry |
Thermochemical changes involve decomposition of the explosives and binders, loss of strength of binder as it softens or melts, or stiffening of the binder if the increased temperature causes crosslinking of the polymer chains. The changes can also significantly alter the porosity of the material, whether by increasing it (fracturing of crystals, vaporization of components) or decreasing it (melting of components). The size distribution of the crystals can be also altered, e.g. by Ostwald ripening. Thermochemical decomposition starts to occur at the crystal nonhomogeneities, e.g. intragranular interfaces between crystal growth zones, on damaged parts of the crystals, or on interfaces of different materials (e.g. crystal/binder). Presence of defects in crystals (cracks, voids, solvent inclusions...) may increase the explosive's sensitivity to mechanical shocks. | 0 | Theoretical and Fundamental Chemistry |
The objective of an atomic bomb is to produce a device, according to Serber, "...in which energy is released by a fast neutron chain reaction in one or more of the materials known to show nuclear fission." According to Rhodes, "Untamped, a bomb core even as large as twice the critical mass would completely fission less than 1 percent of its nuclear material before it expanded enough to stop the chain reaction from proceeding. Tamper always increased efficiency: it reflected neutrons back into the core and its inertia...slowed the cores expansion and helped keep the core surface from blowing away." Rearrangement of the core materials subcritical components would need to proceed as fast as possible to ensure effective detonation. Additionally, a third basic component was necessary, "...an initiator—a Ra + Be source or, better, a Po + Be source, with the radium or polonium attached perhaps to one piece of the core and the beryllium to the other, to smash together and spray neutrons when the parts mated to start the chain reaction." However, any bomb would "necessitate locating, mining and processing hundreds of tons of uranium ore...", while U-235 separation or the production of Pu-239 would require additional industrial capacity. | 0 | Theoretical and Fundamental Chemistry |
1,1-Dichloro-1-fluoroethane is a haloalkane with the formula . It is one of the three isomers of dichlorofluoroethane. It belongs to the hydrochlorofluorocarbon (HCFC) family of man-made compounds that contribute significantly to both ozone depletion and global warming when released into the environment. | 1 | Applied and Interdisciplinary Chemistry |
Detonation spraying produces coatings of very high chemical bond strength and hardness. Coatings are of low porosity, oxygen content and have a low to medium surface roughness. This is achieved due to the extremely high temperatures and velocities produced by the detonation gun during surface coating application. These properties make detonation spraying the standard of comparison for all other thermal spray coatings (wire arc, plasma, flame, HVAF, HVOF, Warm, Cold).
There are many factors that determine the final detonation gun coating properties. Primarily, surface properties are determined by the type and properties of the powdered feedstock used (composition and particle size) but they are also affected by the settings used on the D-gun. These are powder flow rate, firing rate, distance from gun to target, how the D-gun is moved around to apply the coating, size of barrel, amount and composition of fuel and oxygen mixture.
Detonation spraying is able to apply protective coatings to relatively sensitive and delicate materials. This is due to the nature of the application of detonation gun coatings, being very quick and having the heat source removed from the target material. This allows for a large range of suitable applications for detonation spraying. | 1 | Applied and Interdisciplinary Chemistry |
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