text
stringlengths 105
4.57k
| label
int64 0
1
| label_text
stringclasses 2
values |
|---|---|---|
Although multicomponent working fluids have significant thermodynamic advantages over pure (single-component) ones, research and application keep focusing on pure working fluids. However, there are some typical examples for multicomponent based technologies such as Kalina cycle which uses water and ammonia mixture, or absorption refrigerators which also use water and ammonia mixture besides water, ammonia and hydrogen, lithium bromide or lithium chloride mixtures in a majority. Some scientific papers deal with the application of multicomponent working fluids in Organic Rankine cycles as well. These are mainly binary mixtures of hydrocarbons, fluorocarbons, hydrofluorocarbons, siloxanes and inorganic substances. | 0 | Theoretical and Fundamental Chemistry |
Nuclear fallout is the residual radioactive material propelled into the upper atmosphere following a nuclear blast, so called because it "falls out" of the sky after the explosion and the shock wave has passed. It commonly refers to the radioactive dust and ash created when a nuclear weapon explodes. The amount and spread of fallout is a product of the size of the weapon and the altitude at which it is detonated. Fallout may get entrained with the products of a pyrocumulus cloud and fall as black rain (rain darkened by soot and other particulates, which fell within 30–40 minutes of the atomic bombings of Hiroshima and Nagasaki). This radioactive dust, usually consisting of fission products mixed with bystanding atoms that are neutron-activated by exposure, is a form of radioactive contamination. | 0 | Theoretical and Fundamental Chemistry |
Microbial dark matter comprises the vast majority of microbial organisms (usually bacteria and archaea) that microbiologists are unable to culture in the laboratory, due to lack of knowledge or ability to supply the required growth conditions. Microbial dark matter is unrelated to the dark matter of physics and cosmology, but is so-called for the difficulty in effectively studying it as a result of its inability to be cultured by current methods. It is difficult to estimate its relative magnitude, but the accepted gross estimate is that as little as one percent of microbial species in a given ecological niche are culturable. In recent years, more effort has been directed towards deciphering microbial dark matter by means of recovering genome DNA sequences from environmental samples via culture independent methods such as single cell genomics and metagenomics. These studies have enabled insights into the evolutionary history and the metabolism of the sequenced genomes, providing valuable knowledge required for the cultivation of microbial dark matter lineages. | 1 | Applied and Interdisciplinary Chemistry |
Subunit vaccines contain fragments of the pathogen, such as protein or polysaccharide, whose combinations are carefully selected to induce a strong and effective immune response.
Because the immune system interacts with the pathogen in a limited way, the risk of side effects is minimal.
An effective vaccine would elicit the immune response to the antigens and form immunological memory that allows quick recognition of the pathogens and quick response to future infections.
A drawback is that the specific antigens used in a subunit vaccine may lack pathogen-associated molecular patterns which are common to a class of pathogen. These molecular structures may be used by immune cells for danger recognition, so without them, the immune response may be weaker. Another drawback is that the antigens do not infect cells, so the immune response to the subunit vaccines may only be antibody-mediated, not cell-mediated, and as a result, is weaker than those elicited by other types of vaccines.
To increase immune response, adjuvants may be used with the subunit vaccines, or booster doses may be required. | 1 | Applied and Interdisciplinary Chemistry |
A splice site is the border between an exon and intron in a gene. These sites contain a particular sequence motif, which is necessary for recognition and processing by the RNA splicing machinery.
The S&S algorithm uses sliding windows of eight nucleotides, corresponding to the length of the splice site sequence motif, to identify these conserved sequences and thus potential splice sites. Using a weighted table of nucleotide frequencies, the S&S algorithm outputs a consensus-based percentage for the possibility of the window containing a splice site.
The S&S algorithm serves as the basis of other software tools, such as Human Splicing Finder, Splice-site Analyzer Tool, dbass (Ensembl), Alamut, and SROOGLE. | 1 | Applied and Interdisciplinary Chemistry |
Transfer RNA-like structures (tRNA-like structures) are RNA sequences, which have a similar tertiary structure to tRNA; they frequently contain a pseudoknot close to the 3' end. The presence of tRNA-like structures has been demonstrated in many plant virus RNA genomes. These tRNA-like structures are linked to regulation of plant virus replication.
tRNA-like structures mimic some tRNA function, such as aminoacylation. There are three aminoacylation specificities, valine, histidine and tyrosine. For example, valine binds to the tRNA-like structure of the turnip yellow mosaic virus genome whilst tyrosine binds to the tRNA-like structure of the barley stripe mosaic virus genome. tRNA-like structures which lack the 3' termini lack complete or partial tRNA mimicry.
tRNA-like structures are required for RNA encapsulation and increase RNA stability. They also act as 3'-translational enhancers and regulators of minus strand synthesis. | 1 | Applied and Interdisciplinary Chemistry |
A pheromone trap is a type of insect trap that uses pheromones to lure insects. Sex pheromones and aggregating pheromones are the most common types used. A pheromone-impregnated lure, as the red rubber septa in the picture, is encased in a conventional trap such as a bottle trap, Delta trap, water-pan trap, or funnel trap. Pheromone traps are used both to count insect populations by sampling, and to trap pests such as clothes moths to destroy them. | 1 | Applied and Interdisciplinary Chemistry |
Alternatively, Simpson uses:
; Uninervous: Central midrib with no lateral veins (microphyllous), seen in the non-seed bearing tracheophytes, such as horsetails
; Dichotomous: Veins successively branching into equally sized veins from a common point, forming a Y junction, fanning out. Amongst temperate woody plants, Ginkgo biloba is the only species exhibiting dichotomous venation. Also some pteridophytes (ferns).
; Parallel: Primary and secondary veins roughly parallel to each other, running the length of the leaf, often connected by short perpendicular links, rather than form networks. In some species, the parallel veins join at the base and apex, such as needle-type evergreens and grasses. Characteristic of monocotyledons, but exceptions include Arisaema, and as below, under netted.
; Netted (reticulate, pinnate): A prominent midvein with secondary veins branching off along both sides of it. The name derives from the ultimate veinlets which form an interconnecting net like pattern or network. (The primary and secondary venation may be referred to as pinnate, while the net like finer veins are referred to as netted or reticulate); most non-monocot angiosperms, exceptions including Calophyllum. Some monocots have reticulate venation, including Colocasia, Dioscorea and Smilax.
However, these simplified systems allow for further division into multiple subtypes. Simpson, (and others) divides parallel and netted (and some use only these two terms for Angiosperms) on the basis of the number of primary veins (costa) as follows;
; Parallel:
; Netted (Reticulate):
These complex systems are not used much in morphological descriptions of taxa, but have usefulness in plant identification,
although criticized as being unduly burdened with jargon.
An older, even simpler system, used in some flora uses only two categories, open and closed.
* Open: Higher order veins have free endings among the cells and are more characteristic of non-monocotyledon angiosperms. They are more likely to be associated with leaf shapes that are toothed, lobed or compound. They may be subdivided as;
** Pinnate (feather-veined) leaves, with a main central vein or rib (midrib), from which the remainder of the vein system arises
** Palmate, in which three or more main ribs rise together at the base of the leaf, and diverge upward.
** Dichotomous, as in ferns, where the veins fork repeatedly
* Closed: Higher order veins are connected in loops without ending freely among the cells. These tend to be in leaves with smooth outlines, and are characteristic of monocotyledons.
** They may be subdivided into whether the veins run parallel, as in grasses, or have other patterns. | 0 | Theoretical and Fundamental Chemistry |
Janssen was born in Paris (During Bourbon Restoration in France) into a cultivated family. His father, Antoine César Janssen (born in Paris, 1780 – 1860) was a well known clarinettist from Dutch/Belgian descent (his father emigrated from Walloon Brabant to Paris). His mother Pauline Marie Le Moyne (1789 – 1871) was a daughter of the architect Paul Guillaume Le Moyne.
Pierre Janssen studied mathematics and physics at the faculty of sciences. He taught at the Lycée Charlemagne in 1853, and in the school of architecture 1865 – 1871, but his energies were mainly devoted to various scientific missions entrusted to him. Thus in 1857 he went to Peru in order to determine the magnetic equator; in 1861–1862 and 1864, he studied telluric absorption in the solar spectrum in Italy and Switzerland; in 1867 he carried out optical and magnetic experiments at the Azores; he successfully observed both transits of Venus, that of 1874 in Japan, that of 1882 at Oran in Algeria; and he took part in a long series of solar eclipse-expeditions, e.g. to Trani, Italy (1867), Guntur, India (1868), Algiers (1870), Siam (1875), the Caroline Islands (1883), and to Alcossebre in Spain (1905). To see the eclipse of 1870, he escaped from the Siege of Paris in a balloon. Unfortunately the eclipse was obscured from him by cloud.
In the year 1874, Janssen invented the Revolver of Janssen or Photographic Revolver, instrument that originated the chronophotography. Later this invention was of great use for researchers like Etienne Jules Marey to carry out exhibitions and inventions. | 1 | Applied and Interdisciplinary Chemistry |
The solvents are grouped into nonpolar, polar aprotic, and polar protic solvents, with each group ordered by increasing polarity. The properties of solvents which exceed those of water are bolded.
The ACS Green Chemistry Institute maintains a tool for the selection of solvents based on a principal component analysis of solvent properties. | 1 | Applied and Interdisciplinary Chemistry |
The AFM has been applied to problems in a wide range of disciplines of the natural sciences, including solid-state physics, semiconductor science and technology, molecular engineering, polymer chemistry and physics, surface chemistry, molecular biology, cell biology, and medicine.
Applications in the field of solid state physics include (a) the identification of atoms at a surface, (b) the evaluation of interactions between a specific atom and its neighboring atoms, and (c) the study of changes in physical properties arising from changes in an atomic arrangement through atomic manipulation.
In molecular biology, AFM can be used to study the structure and mechanical properties of protein complexes and assemblies. For example, AFM has been used to image microtubules and measure their stiffness.
In cellular biology, AFM can be used to attempt to distinguish cancer cells and normal cells based on a hardness of cells, and to evaluate interactions between a specific cell and its neighboring cells in a competitive culture system. AFM can also be used to indent cells, to study how they regulate the stiffness or shape of the cell membrane or wall.
In some variations, electric potentials can also be scanned using conducting cantilevers. In more advanced versions, currents can be passed through the tip to probe the electrical conductivity or transport of the underlying surface, but this is a challenging task with few research groups reporting consistent data (as of 2004). | 0 | Theoretical and Fundamental Chemistry |
Until 1951, it was not possible to obtain the absolute configuration of chiral compounds. It was at some time decided that (+)-glyceraldehyde was the -enantiomer. The configuration of other chiral compounds was then related to that of (+)-glyceraldehyde by sequences of chemical reactions. For example, oxidation of (+)-glyceraldehyde (1) with mercury oxide gives (−)-glyceric acid (2), a reaction that does not alter the stereocenter. Thus the absolute configuration of (−)-glyceric acid must be the same as that of (+)-glyceraldehyde. Nitric acid oxidation of (+)-isoserine (3) gives (–)-glyceric acid, establishing that (+)-isoserine also has the same absolute configuration. (+)-Isoserine can be converted by a two-stage process of bromination and zinc reduction to give (–)-lactic acid, therefore (–)-lactic acid also has the same absolute configuration. If a reaction gave the enantiomer of a known configuration, as indicated by the opposite sign of optical rotation, it would indicate that the absolute configuration is inverted.
In 1951, Johannes Martin Bijvoet for the first time used in X-ray crystallography the effect of anomalous dispersion, which is now referred to as resonant scattering, to determine absolute configuration. The compound investigated was (+)-sodium rubidium tartrate and from its configuration (R,R) it was deduced that the original guess for (+)-glyceraldehyde was correct.
Despite the tremendous and unique impact on access to molecular structures, X-ray crystallography poses some challenges. The process of crystallization of the target molecules is time- and resource-intensive, and can not be applied to relevant systems of interest such as many biomolecules (some proteins are an exception) and in situ catalysts. Another important limitation is that the molecule must contain "heavy" atoms (for example, bromine) to enhance the scattering. Furthermore, crucial distorsions of the signal arise from the influence of the nearest neighbors in any crystal structure and of solvents used during the crystallization process.
Just recently, novel techniques have been introduced to directly investigate the absolute configuration of single molecules in gas-phase, usually in combination with ab initio quantum mechanical theoretical calculations, therefore overcoming some of the limitations of the X-ray crystallography. | 0 | Theoretical and Fundamental Chemistry |
In 1990, researchers identified the first HIV bNAb, far more powerful than any antibody seen before. They described the exact viral component, or epitope that triggered the antibody. Six amino acids at the tip of HIV's surface protein, gp120, were responsible. The first bNAb turned out to be clinically irrelevant, but in 1994 another team isolated a bNAb that worked on cells taken from patients. This antibody attached to a "conserved" portion of gp120 that outlasts many of its mutations, affecting 17/24 tested strains at low doses. Another bNAb was discovered that acted on protein gp41 across many strains. Antibodies require antigens to trigger them and these were not originally identified.
Over time more bNAbs were isolated, while single cell antibody cloning made it possible to produce large quantities of the antibodies for study. Low levels of bNAbs are now found in up to 25% of HIV patients. bNAbs evolve over years, accumulating some three times as many mutations as other antibodies.
By 2006, researchers had identified a few so-called "broadly neutralizing antibodies" (bNAbs) that worked on multiple HIV strains. They analyzed 1800 blood samples from HIV-infected people from Africa, South Asia and the English-speaking world. They individually probed 30,000 of one woman's antibody-producing B cells and isolated two that were able to stop more than 70% of 162 divergent HIV strains from establishing an infection. Since 2009, researchers have identified more than 50 HIV bNAbs. Integrated web resource BNAber, focused on broadly neutralizing HIV-1 antibodies, has recently been introduced.
In 2006, a Malawian man joined a study within weeks of becoming infected. Over a year, he repeatedly donated blood, which researchers used to create a timeline of changes in his virus' gp120, his antibody response and the ultimate emergence of a bNAb. Researchers want to direct this evolution in other subjects to achieve similar results. A screen of massive gp120 libraries led to one that strongly bound both an original antibody and the mature bNAb that evolved from it. Giving patients a modified gp120 that contains little more than the epitope that both antibodies target could act to "prime" the immune system, followed by a booster that contains trimer spikes in the most natural configuration possible. However, it is still under study whether bNAbs could prevent HIV infection.
In 2009, researchers isolated and characterized the first HIV bNAbs seen in a decade. The two broadest neutralizers were PGT151 and PGT152. They could block about two-thirds of a large panel of HIV strains. Unlike most other bNAbs, these antibodies do not bind to known epitopes, on Env or on Env's subunits (gp120 or gp41). Instead, they attach to parts of both. Gp120 and gp41 assemble as a trimer. The bNAbs binding site occurs only on the trimer structure, the form of Env that invades host cells.
Recent years have seen an increase in HIV-1 bNAb discovery. | 1 | Applied and Interdisciplinary Chemistry |
Carbonate esters undergo many of the reactions of conventional carboxylic acid esters. With Grignard reagents carbonate esters react to give tertiary alcohols. Some cyclic carbonates are susceptible to polymerization. | 0 | Theoretical and Fundamental Chemistry |
In general, if an excitatory synapse is strong enough, an action potential in the presynaptic neuron will trigger an action potential in the postsynaptic cell. In many cases the excitatory postsynaptic potential (EPSP) will not reach the threshold for eliciting an action potential. When action potentials from multiple presynaptic neurons fire simultaneously, or if a single presynaptic neuron fires at a high enough frequency, the EPSPs can overlap and summate. If enough EPSPs overlap, the summated EPSP can reach the threshold for initiating an action potential. This process is known as summation, and can serve as a high pass filter for neurons.
On the other hand, a presynaptic neuron releasing an inhibitory neurotransmitter, such as GABA, can cause an inhibitory postsynaptic potential (IPSP) in the postsynaptic neuron, bringing the membrane potential farther away from the threshold, decreasing its excitability and making it more difficult for the neuron to initiate an action potential. If an IPSP overlaps with an EPSP, the IPSP can in many cases prevent the neuron from firing an action potential. In this way, the output of a neuron may depend on the input of many different neurons, each of which may have a different degree of influence, depending on the strength and type of synapse with that neuron. John Carew Eccles performed some of the important early experiments on synaptic integration, for which he received the Nobel Prize for Physiology or Medicine in 1963. | 1 | Applied and Interdisciplinary Chemistry |
Electric arc guns operate at low voltages (below 45 V dc), but at relatively high currents. They may be safely hand-held. The power supply units are connected to 440 V AC sources, and must be treated with caution. | 1 | Applied and Interdisciplinary Chemistry |
As an endorheic basin, the Caspian Sea basin has no natural connection with the ocean. Since the medieval period, traders reached the Caspian via a number of portages that connected the Volga and its tributaries with the Don River (which flows into the Sea of Azov) and various rivers that flow into the Baltic Sea. Primitive canals connecting the Volga Basin with the Baltic were constructed as early as the early 18th century. Since then, a number of canal projects have been completed.
The two modern canal systems that connect the Volga Basin, and hence the Caspian Sea, with the ocean are the Volga–Baltic Waterway and the Volga–Don Canal.
The proposed Pechora–Kama Canal was a project that was widely discussed between the 1930s and 1980s. Shipping was a secondary consideration. Its main goal was to redirect some of the water of the Pechora River (which flows into the Arctic Ocean) via the Kama River into the Volga. The goals were both irrigation and the stabilization of the water level in the Caspian, which was thought to be falling dangerously fast at the time. During 1971, some peaceful nuclear construction experiments were carried out in the region by the U.S.S.R.
In June 2007, in order to boost his oil-rich countrys access to markets, Kazakhstans President Nursultan Nazarbayev proposed a link between the Caspian Sea and the Black Sea. It is hoped that the "Eurasia Canal" (Manych Ship Canal) would transform landlocked Kazakhstan and other Central Asian countries into maritime states, enabling them to significantly increase trade volume. Although the canal would traverse Russian territory, it would benefit Kazakhstan through its Caspian Sea ports. The most likely route for the canal, the officials at the Committee on Water Resources at Kazakhstan's Agriculture Ministry say, would follow the Kuma–Manych Depression, where currently a chain of rivers and lakes is already connected by an irrigation canal (the Kuma–Manych Canal). Upgrading the Volga–Don Canal would be another option. | 1 | Applied and Interdisciplinary Chemistry |
One study estimated the rate of transposition of a particular retrotransposon, the Ty1 element in Saccharomyces cerevisiae. Using several assumptions, the rate of successful transposition event per single Ty1 element came out to be about once every few months to once every few years. Some TEs contain heat-shock like promoters and their rate of transposition increases if the cell is subjected to stress, thus increasing the mutation rate under these conditions, which might be beneficial to the cell.
Cells defend against the proliferation of TEs in a number of ways. These include piRNAs and siRNAs, which silence TEs after they have been transcribed.
If organisms are mostly composed of TEs, one might assume that disease caused by misplaced TEs is very common, but in most cases TEs are silenced through epigenetic mechanisms like DNA methylation, chromatin remodeling and piRNA, such that little to no phenotypic effects nor movements of TEs occur as in some wild-type plant TEs. Certain mutated plants have been found to have defects in methylation-related enzymes (methyl transferase) which cause the transcription of TEs, thus affecting the phenotype.
One hypothesis suggests that only approximately 100 LINE1 related sequences are active, despite their sequences making up 17% of the human genome. In human cells, silencing of LINE1 sequences is triggered by an RNA interference (RNAi) mechanism. Surprisingly, the RNAi sequences are derived from the 5′ untranslated region (UTR) of the LINE1, a long terminal which repeats itself. Supposedly, the 5′ LINE1 UTR that codes for the sense promoter for LINE1 transcription also encodes the antisense promoter for the miRNA that becomes the substrate for siRNA production. Inhibition of the RNAi silencing mechanism in this region showed an increase in LINE1 transcription. | 1 | Applied and Interdisciplinary Chemistry |
The branched-chain fatty acid synthesizing system uses α-keto acids as primers. This system is distinct from the branched-chain fatty acid synthetase that utilizes short-chain acyl-CoA esters as primers. α-Keto acid primers are derived from the transamination and decarboxylation of valine, leucine, and isoleucine to form 2-methylpropanyl-CoA, 3-methylbutyryl-CoA, and 2-methylbutyryl-CoA, respectively. 2-Methylpropanyl-CoA primers derived from valine are elongated to produce even-numbered iso-series fatty acids such as 14-methyl-pentadecanoic (isopalmitic) acid, and 3-methylbutyryl-CoA primers from leucine may be used to form odd-numbered iso-series fatty acids such as 13-methyl-tetradecanoic acid. 2-Methylbutyryl-CoA primers from isoleucine are elongated to form anteiso-series fatty acids containing an odd number of carbon atoms such as 12-Methyl tetradecanoic acid. Decarboxylation of the primer precursors occurs through the branched-chain α-keto acid decarboxylase (BCKA) enzyme. Elongation of the fatty acid follows the same biosynthetic pathway in Escherichia coli used to produce straight-chain fatty acids where malonyl-CoA is used as a chain extender. The major end products are 12–17 carbon branched-chain fatty acids and their composition tends to be uniform and characteristic for many bacterial species.
BCKA decarboxylase and relative activities of α-keto acid substrates
The BCKA decarboxylase enzyme is composed of two subunits in a tetrameric structure (AB) and is essential for the synthesis of branched-chain fatty acids. It is responsible for the decarboxylation of α-keto acids formed by the transamination of valine, leucine, and isoleucine and produces the primers used for branched-chain fatty acid synthesis. The activity of this enzyme is much higher with branched-chain α-keto acid substrates than with straight-chain substrates, and in Bacillus species its specificity is highest for the isoleucine-derived α-keto-β-methylvaleric acid, followed by α-ketoisocaproate and α-ketoisovalerate. The enzyme's high affinity toward branched-chain α-keto acids allows it to function as the primer donating system for branched-chain fatty acid synthetase.
Factors affecting chain length and pattern distribution
α-Keto acid primers are used to produce branched-chain fatty acids that, in general, are between 12 and 17 carbons in length. The proportions of these branched-chain fatty acids tend to be uniform and consistent among a particular bacterial species but may be altered due to changes in malonyl-CoA concentration, temperature, or heat-stable factors (HSF) present. All of these factors may affect chain length, and HSFs have been demonstrated to alter the specificity of BCKA decarboxylase for a particular α-keto acid substrate, thus shifting the ratio of branched-chain fatty acids produced. An increase in malonyl-CoA concentration has been shown to result in a larger proportion of C17 fatty acids produced, up until the optimal concentration (≈20μM) of malonyl-CoA is reached. Decreased temperatures also tend to shift the fatty-acid distribution slightly toward C17 fatty-acids in Bacillus species. | 1 | Applied and Interdisciplinary Chemistry |
The optimal conditions for TMM cycloadditions depend on both the TMM source and two-atom component. However, a few general principles for each of the TMM sources have emerged.
Reactions of diazenes should employ degassed solvents to avoid radical reactions with oxygen. Tetrahydrofuran (THF) at reflux is the most commonly employed solvent system, but photodissociation conditions at low temperature may also be used.
Reactions employing polar MCPs are usually carried out in a polar solvent to facilitate formation of the TMM intermediate. Although rigorous exclusion of air and water is not required, it is generally preferred.
For transition-metal catalyzed MCP reactions, the choice of catalyst and ligand system is key. Generally, phosphine or phosphite ligands are required in conjunction with a palladium(0) or nickel(0) source; the most common are Pd(dba) and Ni(cod). Tri(isopropyl)phosphine is the most common ligand used with palladium, and triarylphosphites are usually added in nickel-catalyzed reactions.
For transition-metal catalyzed reactions of silylated allylic acetates, the most commonly used catalyst system is palladium(II) acetate and tri(isopropyl)phosphite. Reactions are usually carried out in THF at temperatures ranging from 60 to 110 °C. The choice of solvent or leaving group may affect the course of the reaction. | 0 | Theoretical and Fundamental Chemistry |
Sea and desert birds have been found to have a salt gland near the nostrils which concentrates brine, later to be "sneezed" out to the sea, in effect allowing these birds to drink seawater without the need to find freshwater resources. It also enables the seabirds to remove the excess salt entering the body when eating, swimming or diving in the sea for food. The kidney cannot remove these quantities and concentrations of salt.
The salt secreting gland has been found in seabirds like pelicans, petrels, albatrosses, gulls, and terns. It has also been found in Namibian ostriches and other desert birds, where a buildup of salt concentration is due to dehydration and scarcity of drinking water.
In seabirds the salt gland is above the beak, leading to a main canal above the beak, and water is blown from two small nostrils on the beak, to empty it. The salt gland has two countercurrent mechanisms working in it:
a. A salt extraction system with a countercurrent multiplication mechanism, where salt is actively pumped from the blood venules (small veins) into the gland tubules. Although the fluid in the tubules is with a higher concentration of salt than the blood, the flow is arranged in a countercurrent exchange, so that the blood with a high concentration of salt enters the system close to where the gland tubules exit and connect to the main canal. Thus, all along the gland, there is only a small gradient to climb, in order to push the salt from the blood to the salty fluid with active transport powered by ATP.
b. The blood supply system to the gland is set in countercurrent exchange loop mechanism for keeping the high concentration of salt in the gland's blood, so that it does not leave back to the blood system.
The glands remove the salt efficiently and thus allow the birds to drink the salty water from their environment while they are hundreds of miles away from land. | 1 | Applied and Interdisciplinary Chemistry |
The Cotton effect in physics, is the characteristic change in optical rotatory dispersion and/or circular dichroism in the vicinity of an absorption band of a substance.
In a wavelength region where the light is absorbed, the absolute magnitude of the optical rotation at first varies rapidly with wavelength, crosses zero at absorption maxima and then again varies rapidly with wavelength but in the opposite direction. This phenomenon was discovered in 1895 by the French physicist Aimé Cotton (1869–1951).
The Cotton effect is called positive if the optical rotation first increases as the wavelength decreases (as first observed by Cotton), and negative if the rotation first decreases.
A protein structure such as a beta sheet shows a negative Cotton effect. | 0 | Theoretical and Fundamental Chemistry |
Arsenic is reported to cause DNA modifications such as aneuploidy, micronuclei formation, chromosome abnormality, deletion mutations, sister chromatid exchange and crosslinking of DNA with proteins. It has been demonstrated that arsenic does not directly interact with DNA and it is considered a poor mutagen, but instead, it helps mutagenicity of other carcinogens. For instance, a synergistic increase in the mutagenic activity of arsenic with UV light has been observed in human and other mammalian cells after exposing the UV-treated cells to arsenic. A series of experimental observations suggest that the arsenic genotoxicity is primarily linked to the generation of reactive oxygen species (ROS) during its biotransformation. The ROS production is able to generate DNA adducts, DNA strand breaks, crosslinks and chromosomal aberrations. The oxidative damage is caused by modification of DNA nucleobases, in particular 8-oxoguanine (8-OHdG) which leads to G:C to T:A mutations. Inorganic arsenic can also cause DNA strand break even at low concentrations. | 1 | Applied and Interdisciplinary Chemistry |
An amylase () is an enzyme that catalyses the hydrolysis of starch (Latin ) into sugars. Amylase is present in the saliva of humans and some other mammals, where it begins the chemical process of digestion. Foods that contain large amounts of starch but little sugar, such as rice and potatoes, may acquire a slightly sweet taste as they are chewed because amylase degrades some of their starch into sugar. The pancreas and salivary gland make amylase (alpha amylase) to hydrolyse dietary starch into disaccharides and trisaccharides which are converted by other enzymes to glucose to supply the body with energy. Plants and some bacteria also produce amylase. Specific amylase proteins are designated by different Greek letters. All amylases are glycoside hydrolases and act on α-1,4-glycosidic bonds. | 1 | Applied and Interdisciplinary Chemistry |
The GC-ratio within a genome is found to be markedly variable. These variations in GC-ratio within the genomes of more complex organisms result in a mosaic-like formation with islet regions called isochores. This results in the variations in staining intensity in chromosomes. GC-rich isochores typically include many protein-coding genes within them, and thus determination of GC-ratios of these specific regions contributes to mapping gene-rich regions of the genome. | 1 | Applied and Interdisciplinary Chemistry |
Advantages of HPTLC:
* Provides straightforward information about effects arising from individual compounds in complex or natural samples separated in parallel.
* Combines chromatographic separation with effect-directed detection using enzymatic or biological assays.
* Helps to select important compounds from a sample for further characterization using high-resolution mass spectrometry.
* Offers unique benefits such as super-hyphenation, minimum sample preparation requirements, detection of multi-modulating compounds, and distinguishing agonistic versus antagonistic effects. | 0 | Theoretical and Fundamental Chemistry |
Mice with mutant carboxypeptidase E, Cpe, display endocrine disorders like obesity and infertility. In some strains of mice, the fat mutation also causes hyperproinsulinemia in adult male mice, but this is not found in all strains of mice. The obesity and infertility in the Cpe mice develop with age; young mice ( mice is impaired, with a large accumulation of peptides with C-terminal lysine and/or arginine extensions. Levels of the mature forms of peptides are generally reduced in these mice, but not eliminated. It is thought that a related enzyme (carboxypeptidase D) also contributes to neuropeptide processing and gives rise to the mature peptides in the Cpe mice.
Mutations in the CPE gene are not common within the human population, but have been identified. One patient with extreme obesity (Body Mass Index >50) was found to have a mutation that deleted nearly the entire CPE gene. This patient had intellectual disability (inability to read or write) and had abnormal glucose homeostasis, similar to mice lacking CPE activity.
In obesity, high levels of circulating free fatty acids have been reported to cause a decrease in the amount of carboxypeptidase E protein in pancreatic beta-cells, leading to beta-cell dysfunction (hyperproinsulinemia) and increased beta-cell apoptosis (via an increase in ER stress). However, because CPE is not a rate-limiting enzyme for the production of most neuropeptides and peptide hormones, it is not clear how relatively modest decreases in CPE activity can cause physiological effects. | 1 | Applied and Interdisciplinary Chemistry |
In photo-reflectance, the sample's internal electric field is modulated by the photo-injection of electron-hole pairs (thus reducing the latent field). In order to achieve photo-injection, the energy of photons in the pump beam must exceed the band gap of material within the sample. Furthermore, semiconductors with little or no electric field will exhibit little or no electro-reflectance response. While this situation is not common, this point makes clear the importance of maintaining the probe intensity at a minimum, since any photo-injection of electron-hole pairs from the probe will necessarily offset the sample baseline condition by reducing the latent field. (Likewise, any CW component of the pump is undesirable.) Conversely, if the probe intensity is too low, detection may not be possible with conventional photodiodes. A further consideration is that phase-locked detection is a practical necessity due to the small size of the experimental signals (~ppm) and the unique ability of phase-locked detection methods to reject noise outside a narrow bandwidth centered on the modulation frequency. | 0 | Theoretical and Fundamental Chemistry |
Brill made various trips to the Middle East, including accompanying Theodore Wertimes 1968 survey of the ancient technologies of Iran, alongside other great minds such as the noted ceramicist, Frederick Matson (UCL Institute for Archaeo-Metallurgical Studies 2007). In the years 1963-1964, the Corning Museum of Glass and the University of Missouri, following a long history of excavation at the necropolis of Beth SheArim, conducted an examination of a huge slab of glass, some 2000 years old, that had been languishing in an ancient cistern (Brill and Wosinski 1965). Brill cannot recall who first suggested this slab, measuring 3.4m by 1.94m, could be made of glass, but the only way to test it was to drill a core through its 45 cm thickness and analyse it (Brill 1967, Brill and Wosinski 1965). On analysis of the core, Brill found that the glass was devitrified and stained, and not very homogenous, with a presence of wollastonite crystals throughout (1965, 219.2). Investigation of the manufacture technology required to produce the slab, suggested that in order to produce such a slab of glass, it would have been necessary to heat over eleven tons of batch material, and sustain it at around 1050˚C for between five and ten days (Brill 1967)! His initial interpretation was that the glass must have been heated either from above or from the sides using a kind of tank furnace; a hypothesis that was proven accurate when excavation underneath the slab suggested it had been melted in situ, in a tank whose floor was a bed of limestone blocks with a thin parting layer of clay (Brill and Wosinski 1965, Brill 1967). Brill's interpretation, that the slab and its surroundings suggest ‘some early form of reverberatory furnace’ was the first suggestion of the use of tank furnaces in early glassmaking (1967, 92). The evidence at Beth She’arim encouraged further innovative thought because whilst the slab represented glass production on a grand scale, no associated evidence for glass working was found. Brill had already suspected that historical glassmaking occurred in two phases, the heavy ‘engineering’ stage when the glass is formed from the batch ingredients and the ‘crafting’ stage when the glass is formed into artefacts (Brill, pers. comm., 2009). These stages could occur in combination at one location, or at two differing locales, and the time span of production after the initial glass melt is highly flexible. For Brill, the idea of this ‘dual nature of all glassmaking’ was ‘crystallized’ at Beth She’Arim, where only the raw glass production was represented, and would be reinforced later by the contrasting evidence, where working was favoured over production, found at Jalame, as discussed below (Brill, pers. comm., 2009). | 0 | Theoretical and Fundamental Chemistry |
Scribing is the removal of maskant on the areas to be etched. For decorative applications, this is often done by hand through the use of a scribing knife, etching needle or similar tool; modern industrial applications may involve an operator scribing with the aid of a template or use computer numerical control to automate the process. For parts involving multiple stages of etching, complex templates using colour codes and similar devices may be used. | 1 | Applied and Interdisciplinary Chemistry |
Shown below is a retrosynthetic analysis of phenylacetic acid:
In planning the synthesis, two synthons are identified. A nucleophilic "-COOH" group, and an electrophilic "PhCH" group. Both synthons do not exist as written; synthetic equivalents corresponding to the synthons are reacted to produce the desired product. In this case, the cyanide anion is the synthetic equivalent for the COOH synthon, while benzyl bromide is the synthetic equivalent for the benzyl synthon.
The synthesis of phenylacetic acid determined by retrosynthetic analysis is thus:
: PhCHBr + NaCN → PhCHCN + NaBr
: PhCHCN + 2 HO → PhCHCOOH + NH
In fact, phenylacetic acid has been synthesized from benzyl cyanide, itself prepared by the analogous reaction of benzyl bromide with sodium cyanide. | 0 | Theoretical and Fundamental Chemistry |
Huntington's disease (HD) results from a mutation in the huntingtin gene that causes an excess of CAG repeats. The gene then forms a mutated huntingtin protein with polyglutamine repeats near the amino terminus. This disease is incurable and known to cause motor, cognitive, and behavioral deficits. Researchers have been looking to gene silencing as a potential therapeutic for HD.
Gene silencing can be used to treat HD by targeting the mutant huntingtin protein. The mutant huntingtin protein has been targeted through gene silencing that is allele specific using allele specific oligonucleotides. In this method, the antisense oligonucleotides are used to target single nucleotide polymorphism (SNPs), which are single nucleotide changes in the DNA sequence, since HD patients have been found to share common SNPs that are associated with the mutated huntingtin allele. It has been found that approximately 85% of patients with HD can be covered when three SNPs are targeted. In addition, when antisense oligonucleotides were used to target an HD-associated SNP in mice, there was a 50% decrease in the mutant huntingtin protein.
Non-allele specific gene silencing using siRNA molecules has also been used to silence the mutant huntingtin proteins. Through this approach, instead of targeting SNPs on the mutated protein, all of the normal and mutated huntingtin proteins are targeted. When studied in mice, it was found that siRNA could reduce the normal and mutant huntingtin levels by 75%. At this level, they found that the mice developed improved motor control and a longer survival rate when compared to the controls. Thus, gene silencing methods may prove to be beneficial in treating HD. | 1 | Applied and Interdisciplinary Chemistry |
Ion–dipole and ion–induced dipole forces are similar to dipole–dipole and dipole–induced dipole interactions but involve ions, instead of only polar and non-polar molecules. Ion–dipole and ion–induced dipole forces are stronger than dipole–dipole interactions because the charge of any ion is much greater than the charge of a dipole moment. Ion–dipole bonding is stronger than hydrogen bonding.
An ion–dipole force consists of an ion and a polar molecule interacting. They align so that the positive and negative groups are next to one another, allowing maximum attraction. An important example of this interaction is hydration of ions in water which give rise to hydration enthalpy. The polar water molecules surround themselves around ions in water and the energy released during the process is known as hydration enthalpy. The interaction has its immense importance in justifying the stability of various ions (like Cu) in water.
An ion–induced dipole force consists of an ion and a non-polar molecule interacting. Like a dipole–induced dipole force, the charge of the ion causes distortion of the electron cloud on the non-polar molecule. | 0 | Theoretical and Fundamental Chemistry |
Magnetic inequivalence may occur with two symmetry-related H-C-C-H fragments (where the different subscripts indicate chemical inequivalence) that may or may not be contiguous. In order to distinguish the resulting coupling relationships, the symmetry-related pair would be labelled H-C-C-H. | 0 | Theoretical and Fundamental Chemistry |
A fundamental property of Oseens equation is that the general solution can be split into longitudinal and transversal' waves.
A solution is a longitudinal wave if the velocity is irrotational and hence the viscous term drops out. The equations become
In consequence
Velocity is derived from potential theory and pressure is from linearized Bernoulli's equations.
A solution is a transversal wave if the pressure is identically zero and the velocity field is solenoidal. The equations are
Then the complete Oseen solution is given by
a splitting theorem due to Horace Lamb. The splitting is unique if conditions at infinity (say ) are specified.
For certain Oseen flows, further splitting of transversal wave into irrotational and rotational component is possible Let be the scalar function which satisfies and vanishes at infinity and conversely let be given such that , then the transversal wave is
where is determined from and is the unit vector. Neither or are transversal by itself, but is transversal. Therefore,
The only rotational component is being . | 1 | Applied and Interdisciplinary Chemistry |
* Paper form: It is a strip of coloured paper which changes colour to red if the solution is acidic and to blue, if the solution is basic. The strip can be placed directly onto a surface of a wet substance or a few drops of the solution can be dropped onto the universal indicator using dropping equipment. If the test solution is of a dark colour, it is preferable to use a paper universal indicator, such as Hydrion paper.
* Solution: The main components of a universal indicator, in the form of a solution, are thymol blue, methyl red, bromothymol blue, and phenolphthalein. This mixture is important because each component loses or gains protons depending upon the acidity or alkalinity of the solution being tested. It is beneficial to use this type of universal indicator in a colorless solution. This will increase the accuracy level of indication. | 0 | Theoretical and Fundamental Chemistry |
Three out of 10 advanced colorectal tumors had mutations leading to premature termination of the SFRP1 translation product. The mutations were two single-base deletions (26delG and 67delG) and a single-base change (G450A), which generates an in-frame stop codon. These three mutations were found within the first exon, which was shown previously to be sufficient for Wnt antagonist activity by itself [26, 32]. Of the 10 tumors analyzed, no truncating mutations were found in the second or third exons of SFRP1.
An additional 51 tumors were analyzed via direct sequence analysis, yielding 49 clearly interpretable results. Only the first exon was sequenced for stop codon mutations, but none were found. This indicates that point mutation is not a frequent method of inactivation of the SFRP1 gene in colorectal cancer. | 1 | Applied and Interdisciplinary Chemistry |
Bilirubin di-glucuronide is a conjugated form of bilirubin formed in bilirubin metabolism. The hydrophilic character of bilirubin diglucuronide enables it to be water-soluble. It is pumped across the hepatic canalicular membrane into the bile by the transporter MRP2. | 1 | Applied and Interdisciplinary Chemistry |
See also: Extremophile
The ocean is home to a variety of marine organisms known as extremophiles - organisms that thrive in extreme conditions of temperature, pressure, and light availability. Extremophiles inhabit many unique habitats in the ocean, such as hydrothermal vents, black smokers, cold seeps, hypersaline regions, and sea ice brine pockets. Some scientists have speculated that life may have evolved from hydrothermal vents in the ocean.In hydrothermal vents and similar environments, many extremophiles acquire energy through chemoautotrophy, using chemical compounds as energy sources, rather than light as in photoautotrophy. Hydrothermal vents enrich the nearby environment in chemicals such as elemental sulfur, H, HS, Fe, and methane. Chemoautotrophic organisms, primarily prokaryotes, derive energy from these chemicals through redox reactions. These organisms then serve as food sources for higher trophic levels, forming the basis of unique ecosystems.
Several different metabolisms are present in hydrothermal vent ecosystems. Many marine microorganisms, including Thiomicrospira, Halothiobacillus, and Beggiatoa, are capable of oxidizing sulfur compounds, including elemental sulfur and the often toxic compound HS. HS is abundant in hydrothermal vents, formed through interactions between seawater and rock at the high temperatures found within vents. This compound is a major energy source, forming the basis of the sulfur cycle in hydrothermal vent ecosystems. In the colder waters surrounding vents, sulfur-oxidation can occur using oxygen as an electron acceptor; closer to the vents, organisms must use alternate metabolic pathways or utilize another electron acceptor, such as nitrate. Some species of Thiomicrospira can utilize thiosulfate as an electron donor, producing elemental sulfur. Additionally, many marine microorganisms are capable of iron-oxidation, such as Mariprofundus ferrooxydans. Iron-oxidation can be oxic, occurring in oxygen-rich parts of the ocean, or anoxic, requiring either an electron acceptor such as nitrate or light energy. In iron-oxidation, Fe(II) is used as an electron donor; conversely, iron-reducers utilize Fe(III) as an electron acceptor. These two metabolisms form the basis of the iron-redox cycle and may have contributed to banded iron formations.
At another extreme, some marine extremophiles inhabit sea ice brine pockets where temperature is very low and salinity is very high. Organisms trapped within freezing sea ice must adapt to a rapid change in salinity up to 3 times higher than that of regular seawater, as well as the rapid change to regular seawater salinity when ice melts. Most brine-pocket dwelling organisms are photosynthetic, therefore, these microenvironments can become hyperoxic, which can be toxic to its inhabitants. Thus, these extremophiles often produce high levels of antioxidants. | 0 | Theoretical and Fundamental Chemistry |
The proteins in these excitable domains of neuron when injured may result in cognitive disorders and various neuropathic ailments. | 1 | Applied and Interdisciplinary Chemistry |
In the 1980s, people with cystic fibrosis rarely lived beyond their early teens. Drugs like Pulmozyme and tobramycin, both developed with aid from the ODA, revolutionized treatment for cystic fibrosis patients by significantly improving their quality of life and extending their life expectancies. Now, cystic fibrosis patients often survive into their thirties and some into their fifties. | 1 | Applied and Interdisciplinary Chemistry |
Tank leaching is usually differentiated from vat leaching on the following factors:
# In tank leaching the material is ground sufficiently fine to form a slurry or pulp, which can flow under gravity or when pumped. In vat leaching typically a coarser material is placed in the vat for leaching, this reduces the cost of size reduction;
# Tanks are typically equipped with agitators, baffles, gas introduction equipment designed to maintain the solids in suspension in the slurry, and achieve leaching. Vats usually do not contain much internal equipment, except for agitators.
# Tank leaching is typically continuous, while vat leaching is operated in a batch fashion, this is not always the case, and commercial processes using continuous vat leaching have been tested;
# Typically the retention time required for vat leaching is more than that for tank leaching to achieve the same percentage of recovery of the valuable material being leached;
In a tank leach the slurry is moved, while in a vat leach the solids remain in the vat, and solution is moved. | 1 | Applied and Interdisciplinary Chemistry |
Glutaminolysis takes place in all proliferating cells, such as lymphocytes, thymocytes, colonocytes, adipocytes and especially in tumor cells. Glutaminolysis has been targeted for therapeutic purposes. In tumor cells the citric acid cycle is truncated due to an inhibition of the enzyme aconitase (EC 4.2.1.3) by high concentrations of reactive oxygen species (ROS) Aconitase catalyzes the conversion of citrate to isocitrate.
On the other hand, tumor cells over express phosphate dependent glutaminase and NAD(P)-dependent malate decarboxylase, which in combination with the remaining reaction steps of the citric acid cycle from α-ketoglutarate to citrate impart the possibility of a new energy producing pathway, the degradation of the amino acid glutamine to glutamate, aspartate, pyruvate CO, lactate and citrate.
Besides glycolysis in tumor cells glutaminolysis is another main pillar for energy production. High extracellular glutamine concentrations stimulate tumor growth and are essential for cell transformation. On the other hand, a reduction of glutamine correlates with phenotypical and functional differentiation of the cells. | 1 | Applied and Interdisciplinary Chemistry |
The editor is Lisa Clatworthy. It has been available as an app for mobile devices which was discontinued in mid-2018. It has also trialled a blog, and occasional additional supplements published online. The magazine is published bimonthly in print and operates on "online first" publishing model which supersedes its previous innovations in blogging. Print copies are sent for free to all secondary schools in the UK and Ireland. | 1 | Applied and Interdisciplinary Chemistry |
STRO-1 (Stro-1 in mouse, rat, etc.) is a gene for a protein marker of mesenchymal stem cells (MSC). Molecular mass of Stro-1 is 75kD. The name STRO-1 is firstly proposed in the 1990s as the name of an anti-CD34+-mesenchymal-stem-cell monoclonal antibody. The name "STRO-1" consists of STRO, which means mesenchyme, and "1", which means its the first isolated monoclonal antibody to identify mesenchymal stem cells. The term "STRO-1" then was applied to the antigen for this antibody. In human body, STRO-1 exists in many organs, like lung and liver. | 1 | Applied and Interdisciplinary Chemistry |
According to some definitions, covalent hydrides cover all other compounds containing hydrogen. Some definitions limit hydrides to hydrogen centres that formally react as hydrides, i.e. are nucleophilic, and hydrogen atoms bound to metal centers. These hydrides are formed by all the true non-metals (except zero group elements) and the elements like Al, Ga, Sn, Pb, Bi, Po, etc., which are normally metallic in nature, i.e., this class includes the hydrides of p-block elements. In these substances the hydride bond is formally a covalent bond much like the bond made by a proton in a weak acid. This category includes hydrides that exist as discrete molecules, polymers or oligomers, and hydrogen that has been chem-adsorbed to a surface. A particularly important segment of covalent hydrides are complex metal hydrides, powerful soluble hydrides commonly used in synthetic procedures.
Molecular hydrides often involve additional ligands; for example, diisobutylaluminium hydride (DIBAL) consists of two aluminum centers bridged by hydride ligands. Hydrides that are soluble in common solvents are widely used in organic synthesis. Particularly common are sodium borohydride () and lithium aluminium hydride and hindered reagents such as DIBAL. | 0 | Theoretical and Fundamental Chemistry |
*A 2-year program open to Chemical Engineering technicians with 3–5 years of professional experience.
*60 selected topical-courses delivered by the ENSIC Continuing Education Center. | 1 | Applied and Interdisciplinary Chemistry |
In organic chemistry, the Cieplak effect is a predictive model to rationalize why nucleophiles preferentially add to one face of a carbonyl over another. Proposed by Andrzej Stanislaw Cieplak in 1980, it correctly predicts results that could not be justified by the other standard models at the time, such as the Cram and Felkin–Anh models. In the Cieplak model, electrons from a neighboring bond delocalize into the forming carbon–nucleophile (C–Nuc) bond, lowering the energy of the transition state and accelerating the rate of reaction. Whichever bond can best donate its electrons into the C–Nuc bond determines which face of the carbonyl the nucleophile will add to. The nucleophile may be any of a number of reagents, most commonly organometallic or reducing agents. The Cieplak effect is subtle, and often competes with sterics, solvent effects, counterion complexation of the carbonyl oxygen, and other effects to determine product distribution. Subsequent work has questioned its legitimacy (see Criticisms). | 0 | Theoretical and Fundamental Chemistry |
ZLD processes begin with pre-treatment and evaporation of an industrial effluent until its dissolved solids precipitate. These precipitates are removed and dewatered with a filter press or a centrifuge. The water vapor from evaporation is condensed and returned to the process.
In the last few decades, there has been an effort from the water treatment industry to revolutionize high water recovery and ZLD technologies.
This has led to processes like electrodialysis, forward osmosis, and membrane distillation.
A quick overview and comparison can be seen in the following representative table: | 1 | Applied and Interdisciplinary Chemistry |
Lugols solution is commonly available in different potencies of (nominal) 1%, 2%, 5% or 10%. Iodine concentrations greater than 2.2% are subject to US regulations. If the US regulations are taken literally, their 2.2% maximum iodine concentration limits a Lugols solution to maximum (nominal) 0.87%.
The most commonly used (nominal) 5% solution consists of 5% (wt/v) iodine () and 10% (wt/v) potassium iodide (KI) mixed in distilled water and has a total iodine content of 126.4 mg/mL. The (nominal) 5% solution thus has a total iodine content of 6.32 mg per drop of 0.05 mL; the (nominal) 2% solution has 2.53 mg total iodine content per drop.
Potassium iodide renders the elementary iodine soluble in water through the formation of the triiodide () ion. It is not to be confused with tincture of iodine solutions, which consist of elemental iodine, and iodide salts dissolved in water and alcohol. Lugol's solution contains no alcohol.
Other names for Lugol's solution are (iodine-potassium iodide); Markodine, Strong solution (Systemic); and Aqueous Iodine Solution BP. | 0 | Theoretical and Fundamental Chemistry |
In coordination chemistry, a bridging ligand is a ligand that connects two or more atoms, usually metal ions. The ligand may be atomic or polyatomic. Virtually all complex organic compounds can serve as bridging ligands, so the term is usually restricted to small ligands such as pseudohalides or to ligands that are specifically designed to link two metals.
In naming a complex wherein a single atom bridges two metals, the bridging ligand is preceded by the Greek letter mu, μ, with a subscript number denoting the number of metals bound to the bridging ligand. μ is often denoted simply as μ. When describing coordination complexes care should be taken not to confuse μ with η (eta), which relates to hapticity. Ligands that are not bridging are called terminal ligands. | 0 | Theoretical and Fundamental Chemistry |
Chrysocolla (gold-solder, Greek ; Latin chrȳsocolla, oerugo, santerna; Syriac "tankar" (Bar Bahlul), alchemical symbol 🜸), also known as "goldsmith's solder" and "solder of Macedonia" (Pseudo-Democritus), denotes:
* The soldering of gold.
* The materials used for soldering gold, as well as certain gold alloys, still used by goldsmiths. Martin Ruland (Lexicon alchemiae) explains chrysocolla as molybdochalkos, a copper-lead alloy. In Leyden papyrus X recipe 31 chrysocolla is an alloy composed of 4 parts copper, 2 parts asem (a kind of tin-copper alloy) and 1 part gold. Argyrochrysocolla appears to designate an alloy of gold and silver.
* A mix of copper and iron salts, produced by the dissolution of a metallic vein by water, either spontaneously or by introducing water into a mine from winter to summer, and letting the mass dry during summer, which results in a yellow product.
* Malachite (green carbonate of copper), and other alkaline copper salts of green colour. Azurite, the blue congener of malachite, was known as armenion, as it was mined in Armenia. On heating, malachite decomposes to carbon dioxide and copper, the latter inducing the soldering effect. According to an older opinion, chrysocolla was borax, which had been found in ancient gold foundries and is still used for soldering gold. Aristoteles (De mirabilibus) mentions that the Chalcedonian island Demonesus has a mine of cyan () and chrysocolla. Theophrastus (De lapidibus) describes chrysocolla as a kind of "false emerald" found in gold and copper mines, used for soldering gold. Pliny (Historia Naturalis) and Celsus mention that chrysocolla is extracted along with gold, and is used as a pigment and medicament. Dioscorides (De materia medica) describes the purification of the ore and its use in healing wounds, also noting its poisonous effect.
* Greenish copper salts obtained by boiling infants urine and natron in copper vessels. The resulting copper salts were scraped off and used for soldering gold. Infants urine (Greek , Latin ) appears in many ancient recipes (Dioscorides, Pliny, Celsus, etc.) as a source of phosphates and ammonia.
* A particular copper hydrosilicate is named chrysocolla by modern mineralogists. | 1 | Applied and Interdisciplinary Chemistry |
Another proposal is that the dual-molecule system we see today, where a nucleotide-based molecule is needed to synthesize protein, and a peptide-based (protein) molecule is needed to make nucleic acid polymers, represents the original form of life. This theory is called RNA-peptide coevolution, or the Peptide-RNA world, and offers a possible explanation for the rapid evolution of high-quality replication in RNA (since proteins are catalysts), with the disadvantage of having to postulate the coincident formation of two complex molecules, an enzyme (from peptides) and a RNA (from nucleotides). In this Peptide-RNA World scenario, RNA would have contained the instructions for life, while peptides (simple protein enzymes) would have accelerated key chemical reactions to carry out those instructions. The study leaves open the question of exactly how those primitive systems managed to replicate themselves — something neither the RNA World hypothesis nor the Peptide-RNA World theory can yet explain, unless polymerases (enzymes that rapidly assemble the RNA molecule) played a role.
A research project completed in March 2015 by the Sutherland group found that a network of reactions beginning with hydrogen cyanide and hydrogen sulfide, in streams of water irradiated by UV light, could produce the chemical components of proteins and lipids, alongside those of RNA. The researchers used the term "cyanosulfidic" to describe this network of reactions. In November 2017, a team at the Scripps Research Institute identified reactions involving the compound diamidophosphate which could have linked the chemical components into short peptide and lipid chains as well as short RNA-like chains of nucleotides. | 0 | Theoretical and Fundamental Chemistry |
White-beam topography uses the full bandwidth of X-ray wavelengths in the incoming beam, without any wavelength filtering (no monochromator). The technique is particularly useful in combination with synchrotron radiation sources, due to their wide and continuous wavelength spectrum. In contrast to the monochromatic case, in which accurate sample adjustment is often necessary in order to reach diffraction conditions, the Bragg equation is always and automatically fulfilled in the case of a white X-ray beam: Whatever the angle at which the beam hits a specific lattice plane, there is always one wavelength in the incident spectrum for which the Bragg angle is fulfilled just at this precise angle (on condition that the spectrum is wide enough). White-beam topography is therefore a very simple and fast technique. Disadvantages include the high X-ray dose, possibly leading to radiation damage to the sample, and the necessity to carefully shield the experiment.
White-beam topography produces a pattern of several diffraction spots, each spot being related to one specific lattice plane in the crystal. This pattern, typically recorded on X-ray film, corresponds to a Laue pattern and shows the symmetry of the crystal lattice. The fine structure of each single spot (topograph) is related to defects and distortions in the sample. The distance between spots, and the details of contrast within one single spot, depend on the distance between sample and film; this distance is therefore an important degree of freedom for white-beam topography experiments.
Deformation of the crystal will cause variation in the size of the diffraction spot. For a cylindrically bent crystal the Bragg planes in the crystal lattice will lie on Archimedean spirals (with the exception of those orientated tangentially and radially to the curvature of the bend, which are respectively cylindrical and planar), and the degree of curvature can be determined in a predictable way from the length of the spots and the geometry of the set-up.
White-beam topographs are useful for fast and comprehensive visualization of crystal defect and distortions. They are, however, rather difficult to analyze in any quantitative way, and even a qualitative interpretation often requires considerable experience and time. | 0 | Theoretical and Fundamental Chemistry |
In physical therapy, occupational therapy, and athletic training, a goniometer measures range of motion of limbs and joints of the body. These measurements help accurately track progress in a rehabilitation program. When a patient has decreased range of motion, a therapist assesses the joint before performing an intervention, and continues to use the tool to monitor progress. The therapist can take these range of motion measurements at any joint. They typically require knowledge about the anatomy of the body, particularly bony landmarks. For example, when measuring the knee joint, the therapist places the axis (point of rotation) on the lateral epicondyle of the femur, and lines up the stationary arm with the greater trochanter of the femur. Finally, the therapist lines up the moveable arm of the goniometer with the lateral malleolus of the fibula, and records a measurement using the degree scale on the circular portion of the tool. Reading accuracy is sometimes a problem with goniometers. Issues with the intra-measure (between measures) and inter-tester (between clinicians) reliability may increase as the experience of the examiner decreases. Some studies suggest that these errors can be anywhere between 5 and 10 degrees.
These goniometers come in different forms that some argue increase reliability. The universal standard goniometer is a plastic or metal tool with 1 degree increments. The arms are usually not longer than 12-inches, so it can be hard to accurately pinpoint the exact landmark for measurement. The telescopic-armed goniometer is more reliable—with a plastic circular axis like a classic goniometer, but with arms that extend to as long as two feet in either direction.
More recently in the twenty-first century, smartphone application developers have created mobile applications that provide the functions of a goniometer. These applications (such as Knee Goniometer and Goniometer Pro) use the accelerometers in phones to calculate joint angles. Recent research supports these applications and their devices as reliable and valid tools with as much accuracy as a universal goniometer.
Modern rehabilitative therapy motion capture systems perform goniometry at the very least measuring active range of motion. While in some cases accuracy may be inferior to a goniometer, measuring angles with a motion capture system is superior at measuring during dynamic, as opposed to static situations. Furthermore, using a traditional goniometer takes valuable time. In the clinical context, performing manual measurements takes valuable time and may not be practical. | 0 | Theoretical and Fundamental Chemistry |
Type I photooxygenation reactions are frequently used in the process of forming and trapping diradical species. Mirbach et al. reported on one such reaction in which an azo compound is lysed via photolysis to form the diradical hydrocarbon and then trapped in a stepwise fashion by molecular oxygen: | 0 | Theoretical and Fundamental Chemistry |
TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.
Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40. | 1 | Applied and Interdisciplinary Chemistry |
SBTi developed separate sector-specific methodologies, frameworks and requirements for different industries. As of December 2021, guidance is available for:
* Aviation
* Apparel and footwear
* Financial institutions
* Information and Communication Technology | 1 | Applied and Interdisciplinary Chemistry |
Acetic anhydride is a major industrial chemical widely used for preparing acetate esters, e.g. cellulose acetate. Maleic anhydride is the precursor to various resins by copolymerization with styrene. Maleic anhydride is a dienophile in the Diels-Alder reaction.
Dianhydrides, molecules containing two acid anhydride functions, are used to synthesize polyimides and sometimes polyesters and polyamides. Examples of dianhydrides: pyromellitic dianhydride (PMDA), 3,3’, 4,4’ - oxydiphtalic dianhydride (ODPA), 3,3’, 4,4’-benzophenone tetracarboxylic dianhydride (BTDA), 4,4’-diphtalic (hexafluoroisopropylidene) anhydride (6FDA), benzoquinonetetracarboxylic dianhydride, ethylenetetracarboxylic dianhydride. Polyanhydrides are a class of polymers characterized by anhydride bonds that connect repeat units of the polymer backbone chain. | 0 | Theoretical and Fundamental Chemistry |
Haploid yeast switch mating type by replacing the information present at the MAT locus. For example, an a cell will switch to an α cell by replacing the MATa allele with the MATα allele. This replacement of one allele of MAT for the other is possible because yeast cells carry an additional silenced copy of both the MATa and MATα alleles: the HML (homothallic mating left) locus typically carries a silenced copy of the MATα allele, and the HMR (homothallic mating right) locus typically carries a silenced copy of the MATa allele. The silent HML and HMR loci are often referred to as the silent mating cassettes, as the information present there is read into the active MAT locus.
These additional copies of the mating type information do not interfere with the function of whatever allele is present at the MAT locus because they are not expressed, so a haploid cell with the MATa allele present at the active MAT locus is still an a cell, despite also having a (silenced) copy of the MATα allele present at HML. Only the allele present at the active MAT locus is transcribed, and thus only the allele present at MAT will influence cell behaviour. Hidden mating type loci are epigenetically silenced by SIR proteins, which form a heterochromatin scaffold that prevents transcription from the silent mating cassettes. | 1 | Applied and Interdisciplinary Chemistry |
Although ammonium bicarbonate has been utilized in the manufacturing of titanium foams, it is not an ideal spacer in that it has a low melting/dissociation point and some solubility in titanium. This results in considerable shrinkage which makes control of pore shape difficult. Furthermore, the decomposition releases environmentally harmful gases. | 0 | Theoretical and Fundamental Chemistry |
In 1914, Polanyi wrote his first paper proposed on adsorption where he proposed a model for the adsorption of gas onto a solid surface. Afterwards, he published a fully developed paper in 1916, which included experimental verification by his students and other authors.
During his research in the University of Budapest, his mentor, Professor Georg Bredig, sent his research findings to Albert Einstein. Einstein wrote back to Bredig stating:
Polanyi later described this event by saying:
Polanyi and Einstein continued to write to each other on and off for the next 20 years. | 0 | Theoretical and Fundamental Chemistry |
Photogeochemical reactions may be classified based on thermodynamics and/or the nature of the materials involved. In addition, when ambiguity exists regarding an analogous reaction involving light and living organisms (phototrophy), the term "photochemical" may be used to distinguish a particular abiotic reaction from the corresponding photobiological reaction. For example, "photooxidation of iron(II)" can refer to either a biological process driven by light (phototrophic or photobiological iron oxidation) or a strictly chemical, abiotic process (photochemical iron oxidation). Similarly, an abiotic process that converts water to O under the action of light may be designated "photochemical oxidation of water" rather than simply "photooxidation of water", in order to distinguish it from photobiological oxidation of water potentially occurring in the same environment (by algae, for example). | 0 | Theoretical and Fundamental Chemistry |
Nuclear medicine, also known as nucleology, is a medical specialty that uses radioactive substances to diagnose and treat diseases. Unlike traditional radiology, which records radiation transmitted through the body from external sources like X-ray generators, nuclear imaging records radiation emitted from within the body. The focus of nuclear medicine scans is on the function of organs and tissues rather than their anatomy. This is why it is referred to as a physiological imaging modality. Nuclear medicine utilises two primary imaging modalities, single photon emission computed tomography (SPECT) and positron emission tomography (PET) scans. These are commonly used in the field. It is important to note that SPECT and PET scans are the two most common imaging modalities in nuclear medicine. | 1 | Applied and Interdisciplinary Chemistry |
Bioplastics can be made from proteins from different sources. For example, wheat gluten and casein show promising properties as a raw material for different biodegradable polymers.
Additionally, soy protein is being considered as another source of bioplastic. Soy proteins have been used in plastic production for over one hundred years. For example, body panels of an original Ford automobile were made of soy-based plastic.
There are difficulties with using soy protein-based plastics due to their water sensitivity and relatively high cost. Therefore, producing blends of soy protein with some already-available biodegradable polyesters improves the water sensitivity and cost. | 0 | Theoretical and Fundamental Chemistry |
It is possible to form a bond between two carbons of (-) polarity by using an oxidant such as iodine. In this total synthesis of enterolactone, the 1,4- relationship of oxygen substituents is assembled by the oxidative homocoupling of a carboxylate enolate using iodine as the oxidant. | 0 | Theoretical and Fundamental Chemistry |
The secretion pattern of thyrotropin (TSH) is shaped by infradian, circadian and ultradian rhythms. Infradian rhythmis are mainly represented by circannual variation mirroring the seasonality of thyroid function. Circadian rhythms lead to a peak secretion (acrophase) around midnight and nadir concentrations around noon and in the early afternoon. A similar pattern is observed for triiodothyronine, however with a phase shift. Pulsatile release contributes to the ultradian rhythm of TSH concentration with about 10 pulses per 24 hours. The amplitude of the circadian and ultradian rhythms is reduced in severe non-thyroidal illness syndrome (TACITUS).
Contemporary theories assume that autocrine and paracrine (ultrashort) feedback mechanisms controlling TSH secretion within the anterior pituitary gland are a major factor contributing to the evolution of its pulsatility. | 1 | Applied and Interdisciplinary Chemistry |
In thermochemistry, an exothermic reaction is a "reaction for which the overall standard enthalpy change ΔH⚬ is negative." Exothermic reactions usually release heat. The term is often confused with exergonic reaction, which IUPAC defines as "... a reaction for which the overall standard Gibbs energy change ΔG⚬ is negative." A strongly exothermic reaction will usually also be exergonic because ΔH⚬ makes a major contribution to ΔG⚬. Most of the spectacular chemical reactions that are demonstrated in classrooms are exothermic and exergonic. The opposite is an endothermic reaction, which usually takes up heat and is driven by an entropy increase in the system. | 0 | Theoretical and Fundamental Chemistry |
Cell engineering is the purposeful process of adding, deleting, or modifying genetic sequences in living cells to achieve biological engineering goals such as altering cell production, changing cell growth and proliferation requirements, adding or removing cell functions, and many more. Cell engineering often makes use of DNA technology to achieve these modifications as well as closely related tissue engineering methods. Cell engineering can be characterized as an intermediary level in the increasingly specific disciplines of biological engineering which includes organ engineering, tissue engineering, protein engineering, and genetic engineering.
The field of cellular engineering is gaining more traction as biomedical research advances in tissue engineering and becomes more specific. Publications in the field have gone from several thousand in the early 2000s to nearly 40,000 in 2020. | 1 | Applied and Interdisciplinary Chemistry |
Electrochemiluminescence or electrogenerated chemiluminescence (ECL) is a kind of luminescence produced during electrochemical reactions in solutions. In electrogenerated chemiluminescence, electrochemically generated intermediates undergo a highly exergonic reaction to produce an electronically excited state that then emits light upon relaxation to a lower-level state. This wavelength of the emitted photon of light corresponds to the energy gap between these two states. ECL excitation can be caused by energetic electron transfer (redox) reactions of electrogenerated species. Such luminescence excitation is a form of chemiluminescence where one/all reactants are produced electrochemically on the electrodes.
ECL is usually observed during application of potential (several volts) to electrodes of electrochemical cell that contains solution of luminescent species (polycyclic aromatic hydrocarbons, metal complexes, quantum dots or nanoparticles) in aprotic organic solvent (ECL composition).
In organic solvents both oxidized and reduced forms of luminescent species can be produced at different electrodes simultaneously or at a single one by sweeping its potential between oxidation and reduction. The excitation energy is obtained from recombination of oxidized and reduced species.
In aqueous medium, which is mostly used for analytical applications, simultaneous oxidation and reduction of luminescent species is difficult to achieve due to electrochemical splitting of water itself so the ECL reaction with the coreactants is used. In the latter case luminescent species are oxidized at the electrode together with the coreactant which gives a strong reducing agent after some chemical transformations (the oxidative reduction mechanism). | 0 | Theoretical and Fundamental Chemistry |
Suzanne A. Blum is an American professor of chemistry at the University of California, Irvine. Blum works on mechanistic chemistry, most recently focusing on borylation reactions and the development of single-molecule and single-particle fluorescence microscopy to study organic chemistry and catalysis. She received the American Chemical Society's Arthur C. Cope Scholar Award in 2023. | 0 | Theoretical and Fundamental Chemistry |
In molecular biology and biotechnology, a fluorescent tag, also known as a fluorescent label or fluorescent probe, is a molecule that is attached chemically to aid in the detection of a biomolecule such as a protein, antibody, or amino acid. Generally, fluorescent tagging, or labeling, uses a reactive derivative of a fluorescent molecule known as a fluorophore. The fluorophore selectively binds to a specific region or functional group on the target molecule and can be attached chemically or biologically. Various labeling techniques such as enzymatic labeling, protein labeling, and genetic labeling are widely utilized. Ethidium bromide, fluorescein and green fluorescent protein are common tags. The most commonly labelled molecules are antibodies, proteins, amino acids and peptides which are then used as specific probes for detection of a particular target. | 1 | Applied and Interdisciplinary Chemistry |
Gene therapy encapsulates many forms of adding different nucleic acids to a cell. Gene augmentation adds a new protein coding gene to a cell. One form of gene augmentiation is gene replacement therapy, a treatment for monogenic recessive disorders where a single gene is not functional an additional functional gene is added. For diseases caused by multiple genes or a dominant gene, gene silencing or gene editing approaches are more appropriate but gene addition, a form of gene augmentation where new gene is added, may improve a cells function without modifying the genes that cause a disorder. | 1 | Applied and Interdisciplinary Chemistry |
The glyoxylate cycle, a variation of the tricarboxylic acid cycle, is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates. In microorganisms, the glyoxylate cycle allows cells to use two carbons (C2 compounds), such as acetate, to satisfy cellular carbon requirements when simple sugars such as glucose or fructose are not available. The cycle is generally assumed to be absent in animals, with the exception of nematodes at the early stages of embryogenesis. In recent years, however, the detection of malate synthase (MS) and isocitrate lyase (ICL), key enzymes involved in the glyoxylate cycle, in some animal tissue has raised questions regarding the evolutionary relationship of enzymes in bacteria and animals and suggests that animals encode alternative enzymes of the cycle that differ in function from known MS and ICL in non-metazoan species.
Plants as well as some algae and bacteria can use acetate as the carbon source for the production of carbon compounds. Plants and bacteria employ a modification of the TCA cycle called the glyoxylate cycle to produce four carbon dicarboxylic acid from two carbon acetate units. The glyoxylate cycle bypasses the two oxidative decarboxylation reactions of the TCA cycle and directly converts isocitrate through isocitrate lyase and malate synthase into malate and succinate.
The glyoxylate cycle was discovered in 1957 at the University of Oxford by Sir Hans Kornberg and his mentor Hans Krebs, resulting in a Nature paper Synthesis of Cell Constituents from C-Units by a Modified Tricarboxylic Acid Cycle. | 1 | Applied and Interdisciplinary Chemistry |
Standard conditions for using NBS in allylic and/or benzylic bromination involves refluxing a solution of NBS in anhydrous CCl with a radical initiator—usually azobisisobutyronitrile (AIBN) or benzoyl peroxide, irradiation, or both to effect radical initiation. The allylic and benzylic radical intermediates formed during this reaction are more stable than other carbon radicals and the major products are allylic and benzylic bromides. This is also called the Wohl–Ziegler reaction.
The carbon tetrachloride must be maintained anhydrous throughout the reaction, as the presence of water may likely hydrolyze the desired product. Barium carbonate is often added to maintain anhydrous and acid-free conditions.
In the above reaction, while a mixture of isomeric allylic bromide products are possible, only one is created due to the greater stability of the 4-position radical over the methyl-centered radical. | 0 | Theoretical and Fundamental Chemistry |
In genetics, a super-enhancer is a region of the mammalian genome comprising multiple enhancers that is collectively bound by an array of transcription factor proteins to drive transcription of genes involved in cell identity. Because super-enhancers are frequently identified near genes important for controlling and defining cell identity, they may thus be used to quickly identify key nodes regulating cell identity.
Enhancers have several quantifiable traits that have a range of values, and these traits are generally elevated at super-enhancers. Super-enhancers are bound by higher levels of transcription-regulating proteins and are associated with genes that are more highly expressed. Expression of genes associated with super-enhancers is particularly sensitive to perturbations, which may facilitate cell state transitions or explain sensitivity of super-enhancer—associated genes to small molecules that target transcription. | 1 | Applied and Interdisciplinary Chemistry |
An improvement on vibration, vibratory, and linear screeners, a tumbler screener uses elliptical action which aids in screening of even very fine material. As like panning for gold, the fine particles tend to stay towards the center and the larger go to the outside. It allows for segregation and unloads the screen surface so that it can effectively do its job. With the addition of multiple decks and ball cleaning decks, even difficult products can be screened at high capacity to very fine separations. | 1 | Applied and Interdisciplinary Chemistry |
The aglycones of both phlorizin and dapagliflozin have weak inhibition effects on SGLT-1 and SGLT-2. Two synergistic forces are involved in binding of inhibitors to SGLTs. Different sugars on the aglycone will affect and change the orientation of it in the access vestibule because one of the forces involved in the binding is the binding of sugar to the glucose site. The other force is the binding of the aglycone, which affects the binding affinity of the entire inhibitor.
The discovery of T-1095 led to an investigation of how to enhance potency, selectivity and oral bioavailability by adding various substituents to the glycoside core. As an example we can take the change of o-glycosides to c-glycosides by creating a carbon–carbon bond between the glucose and the aglycone moiety. C-glucosides are more stable than o-glucosides which leads to modified half-life and duration of action. These modifications have also led to more specificity to SGLT-2. C-glucosides that have heterocyclic ring at the distal ring or proximal ring are better when it comes to anti-diabetic effect and physicochemical features all together. C-glucoside bearing thiazole at the distal ring on canagliflozin has shown good physicochemical properties that can lead to a clinical development, but still has the same anti-diabetic activity as dapagliflozin, as shown in tables 1 and 2.
Song and his partners did preparate thiazole compound by starting with carboxyl acid. Working with that, it took them three steps to get a compound like dapagliflozin with a thiazole ring. Inhibitory effects on SGLT-2 of the compounds were tested by Song and his partners. In tables 1, 2, and 3, the IC value changes depending on what compound is in the ring position, in the C-4 region of the proximal phenyl ring, and how the thiazole ring relates.
Many compounds gave different IC value in the ring position in an in vitro activity. For an example there was a big difference if there was an n-pentyl group (IC = 13,3 nM), n-butyl (IC = 119 nM), phenyl with 2-furyl (IC = 0,720) or 3-thiophenyl (IC = 0,772). As seen in table 1, the in vitro activity increases depending on what compound is bonded to the distal ring (given that in the C-4 region of the proximal phenyl ring is a Cl atom).
Table 1: Differences in in vitro activity depending on which compound is bonded to the distal ring.
*comparator to ethyl group (IC = 16,7)
In table 2, the in vitro activity changes depending on the compound in the C-4 region of the proximal phenyl ring (X). Small methyl groups or other halogen atoms in the C-4 position gave IC ranging from 0.72–36.7 (given that the phenyl with 2-furyl is in the ring position).
Table 2: Differences in in vitro activity depending on what compound is in the C-4 region of the proximal phenyl ring.
Table 3: Difference in the IC value depending on how the thiazole ring relates (nothing else is changed in the structure (X = Cl, R = phenyl with 2-furyl). | 1 | Applied and Interdisciplinary Chemistry |
The Single Liquid battery or the Alkali sulfur liquid battery was invented in 2013 by Pasidu Pallawela. According to World Intellectual property organisation WIPO Pasidu Pallawela and StorTera holds patent rights to this technology. This technology has been presented in several high-profile industrial energy conferences such as All Energy conference and exhibition in the UK. As a business innovation, this technology was nominated for MEL British Chamber of commerce Awards in 2017 as the best business innovation and won the category award. SLIQ also won several Rushlight awards in 2020, winning the overall Rushlight award, energy environmental group category award and the Energy Efficiency group Award. | 1 | Applied and Interdisciplinary Chemistry |
In organosilicon chemistry, silyl enol ethers are a class of organic compounds that share the common functional group , composed of an enolate () bonded to a silane () through its oxygen end and an ethene group () as its carbon end. They are important intermediates in organic synthesis. | 0 | Theoretical and Fundamental Chemistry |
More than 100 ECS student chapters are located in major universities in all of these regions as well as Asia, Europe, Latin America, the Middle East, North America, South Africa, and Southern Asia. | 0 | Theoretical and Fundamental Chemistry |
There are historical reports of acute hypervitaminosis from Arctic explorers consuming bearded seal or polar bear liver, both very rich sources of stored retinol, and there are also case reports of acute hypervitaminosis from consuming fish liver, but otherwise there is no risk from consuming too much via commonly consumed foods. Only consumption of retinol-containing dietary supplements can result in acute or chronic toxicity. Acute toxicity occurs after a single or short-term doses of greater than 150,000 μg. Symptoms include blurred vision, nausea, vomiting, dizziness and headache within 8 to 24 hours. For infants ages 0–6 months given an oral dose to prevent development of vitamin A deficiency, bulging skull fontanel was evident after 24 hours, usually resolved by 72 hours. Chronic toxicity may occur with long-term consumption of vitamin A at doses of 25,000–33,000 IU/day for several months. Excessive consumption of alcohol can lead to chronic toxicity at lower intakes. Symptoms may include nervous system effects, liver abnormalities, fatigue, muscle weakness, bone and skin changes and others. The adverse effects of both acute and chronic toxicity are reversed after consumption is stopped.
In 2001, for the purpose of determining ULs for adults, the US Institute of Medicine considered three primary adverse effects and settled on two: teratogenicity, i.e., causing birth defects, and liver abnormalities. Reduced bone mineral density was considered, but dismissed because the human evidence was contradictory. During pregnancy, especially during the first trimester, consumption of retinol in amounts exceeding 4,500 μg/day increased the risk of birth defects, but not below that amount, thus setting a "No-Observed Adverse-Effect Level" (NOAEL). Given the quality of the clinical trial evidence, the NOAEL was divided by an uncertainty factor of 1.5 to set the UL for women of reproductive age at 3,000 μg/day of preformed vitamin A. For all other adults, liver abnormalities were detected at intakes above 14,000 μg/day. Given the weak quality of the clinical evidence, an uncertainty factor of 5 was used, and with rounding, the UL was set at 3,000 μg/day. Despite a US UL set at 3,000 μg, it is possible to buy over-the-counter dietary supplement products which are 7,500 μg (25,000 IU), with a label caution statement "Not intended for long term use unless under medical supervision."
For children, ULs were extrapolated from the adult value, adjusted for relative body weight. For infants, several case studies reported adverse effects that include bulging fontanels, increased intracranial pressure, loss of appetite, hyperirritability and skin peeling after chronic ingestion of the order of 6,000 or more μg/day. Given the small database, an uncertainty factor of 10 divided into the "Lowest-Observed-Adverse-Effect Level" (LOAEL) led to a UL of 600 μg/day. | 1 | Applied and Interdisciplinary Chemistry |
In 2009, a Chinese cement company (in Tongchuan, Shaanxi Province) was demolishing an old, unused cement plant and did not follow standards for handling radioactive materials. This caused some caesium-137 from a measuring instrument to be included with eight truckloads of scrap metal on its way to a steel mill, where the radioactive caesium was melted down into the steel. | 0 | Theoretical and Fundamental Chemistry |
Charge-exchange spectroscopy (abbreviated CES or CXS) is a technique commonly used in plasma diagnostics to analyze high-temperature controlled fusion plasmas. In fusion plasmas, the light elements tend to become fully ionized during operation, which makes it challenging to diagnose their properties using conventional optical diagnostics. To address this, a method was developed in the 1970s which involves the injection of a beam of neutral atoms, such as hydrogen or deuterium, into the plasma. This process results in the ionization of hydrogenic atoms the excitation of ions through charge exchange, as represented by the reaction:
where represents the various possible charged states of the ions in the plasma.
Optical fibers are then strategically positioned to create "chords", lines of sight along which the measurements are taken. These chords pass through regions both with and without the neutral beam. By subtracting the signals from these two chords, emissions not generated by the neutral beam can be inferred. This allows for the determination of ion properties, such as its temperature and density.
The technique can also be extended to include multiple chords to build spatial profiles of the plasma, such as its toroidal and poloidal rotation. This provides insights into how ions conduct heat and transport momentum within the plasma.
Charge-exchange spectroscopy is often referred to as charge-exchange recombination spectroscopy, which is acronymized as CXRS or CER. | 0 | Theoretical and Fundamental Chemistry |
Gallium arsenide (GaAs) is a III-V direct band gap semiconductor with a zinc blende crystal structure.
Gallium arsenide is used in the manufacture of devices such as microwave frequency integrated circuits, monolithic microwave integrated circuits, infrared light-emitting diodes, laser diodes, solar cells and optical windows.
GaAs is often used as a substrate material for the epitaxial growth of other III-V semiconductors, including indium gallium arsenide, aluminum gallium arsenide and others. | 0 | Theoretical and Fundamental Chemistry |
* Clancy, L.J. (1975), Aerodynamics, Pitman Publishing Limited, London
* "[https://web.archive.org/web/20060427140337/http://www.weather.com/glossary/v.html Weather Glossary]"' The Weather Channel Interactive, Inc.. 2004.
* "[http://www.tpub.com/content/aerographer/14010/css/14010_18.htm Vorticity]". Integrated Publishing. | 1 | Applied and Interdisciplinary Chemistry |
Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.
Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers. In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches. | 1 | Applied and Interdisciplinary Chemistry |
Seeding a material is a concept used in fluid dynamics to describe the act of introducing specific particulates or other foreign substances into a stream of fluid being evaluated. An altered fluid will be described as having a seeded flow. | 1 | Applied and Interdisciplinary Chemistry |
Eva Smolková-Keulemansová, Weilová (27 April 1927 – 27 February 2024) was a survivor of Auschwitz, Neuengamme, and Bergen-Belsen concentration camps. After her liberation, she became a renowned Czech scientist and professor of analytical science at Charles University in Prague. | 0 | Theoretical and Fundamental Chemistry |
In October 2006, Finnish paper and pulp manufacturer UPM announced its plans to produce biodiesel by the Fischer–Tropsch process alongside the manufacturing processes at its European paper and pulp plants, using waste biomass resulting from paper and pulp manufacturing processes as source material. | 0 | Theoretical and Fundamental Chemistry |
In the field of environmental science, adsorption is involved in many parts of technologies that can eliminate pollutants and governs the concentration of chemicals in soils and/or atmosphere. When studying pollutant degradation or the geochemical process, the pzc value related to adsorption has been examined. For example, natural and organic substrates including wood ash, sawdust, etc. are to be used as an adsorbent by eliminating harmful heavy metals like arsenic, cobalt, mercury ion and so forth in contaminated neutral drainage (CND), which is a passive reactor that could possible metal adsorption with low-cost materials. Therefore, the pzc values of the organic substrates were evaluated to optimize the selection of materials in CND. Another example is that the emission of nitrous acid, which controls the atmosphere's oxidative capacity. Different soil pH leads to the different surface charges of minerals so the emission of nitrous acid would be varied, further impacting on the biological cycle involved in the nitrous acid species. | 0 | Theoretical and Fundamental Chemistry |
The BANA test (referring to the enzymatic breakdown of [N-benzoyl-dL-arginine-2-napthylamide]) is used to determine the proteolytic activity of certain oral anaerobes that contribute to oral malodor. Some bacteria, e.g. Prophyromona gingivalis, Treponema denticola, and Bacteroides forsythus (Red complex) produce waste products that are quite odiferous, and as a result contribute to bad breath.
When a sample of a patient's saliva that contains these bacteria is placed within the BANA testing compound, it causes the breakdown of the N-benzoyl enzyme. As a result of this biodegradation occurs, the test compound changes color, indicating a positive reaction.
Uses: Used to identify volatile Sulphur compounds in halitosis patients. | 1 | Applied and Interdisciplinary Chemistry |
The metabolic (catabolic fate) of propionyl-CoA depends on what environment it is being synthesized in. Therefore, propionyl-CoA in an anaerobic environment could have a different fate than that in an aerobic organism. The multiple pathways, either catabolism by propionyl-CoA carboxylase or methylcitrate synthase, also depend on the presence of various genes. | 1 | Applied and Interdisciplinary Chemistry |
The material properties of the metal interconnects have a strong influence on the life span. The characteristics are predominantly the composition of the metal alloy and the dimensions of the conductor. The shape of the conductor, the crystallographic orientation of the grains in the metal, procedures for the layer deposition, heat treatment or annealing, characteristics of the passivation and the interface to other materials also affect the durability of the interconnects. There are also important differences with time dependent current: direct current or different alternating current waveforms cause different effects. | 0 | Theoretical and Fundamental Chemistry |
RNA interference (RNAi) is a natural process used by cells to regulate gene expression. It was discovered in 1998 by Andrew Fire and Craig Mello, who won the Nobel Prize for their discovery in 2006. The process to silence genes first begins with the entrance of a double-stranded RNA (dsRNA) molecule into the cell, which triggers the RNAi pathway. The double-stranded molecule is then cut into small double-stranded fragments by an enzyme called Dicer. These small fragments, which include small interfering RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides in length. The fragments integrate into a multi-subunit protein called the RNA-induced silencing complex, which contains Argonaute proteins that are essential components of the RNAi pathway. One strand of the molecule, called the "guide" strand, binds to RISC, while the other strand, known as the "passenger" strand is degraded. The guide or antisense strand of the fragment that remains bound to RISC directs the sequence-specific silencing of the target mRNA molecule. The genes can be silenced by siRNA molecules that cause the endonucleatic cleavage of the target mRNA molecules or by miRNA molecules that suppress translation of the mRNA molecule. With the cleavage or translational repression of the mRNA molecules, the genes that form them are rendered essentially inactive. RNAi is thought to have evolved as a cellular defense mechanism against invaders, such as RNA viruses, or to combat the proliferation of transposons within a cell's DNA. Both RNA viruses and transposons can exist as double-stranded RNA and lead to the activation of RNAi. Currently, siRNAs are being widely used to suppress specific gene expression and to assess the function of genes. Companies utilizing this approach include Alnylam, Sanofi, Arrowhead, Discerna, and Persomics, among others. | 1 | Applied and Interdisciplinary Chemistry |
𝜶 and β particles are both used in the treatment of cancers, depending on the size and location of the particular tumor. Alpha particles contain overall higher energy and have a shorter path length, and have greater cytotoxic properties for this reason as compared to β particles. However, due to the shorter path length of these particles, the method of delivery needs to be extremely close to the location of the tumor. Currently, treatments using alpha-emitters exist which consist of alpha emitters attached to carrier molecules. Some examples of alpha-emitting radioligands include actinium-225, Ra-223-chloride, and Lead-212.36
β particles emit lower energy as compared to α-emitters, but they have the advantage of having longer path length. However, due to their lower energy, more β particles are required to cause damage to tumor cells as compared to α-emitters. Some examples of β-emitters include Lu-177, Y-90, and I-131. | 1 | Applied and Interdisciplinary Chemistry |
Reactions of relatively simple coordination complexes have been examined as tests of PCET.
*The comproportionation of a Ru(II) aquo and a Ru(IV) oxo (bipy = (2,2'-bipyridine, py = pyridine):
:[(bipy)(py)Ru(O)] + [(bipy)(py)Ru(OH)] → 2 [(bipy)(py)Ru(OH)]
*Electrochemical reactions where reduction is coupled to protonation or where oxidation is coupled to deprotonation. | 0 | Theoretical and Fundamental Chemistry |
With the use of Green's function, the Lippmann–Schwinger equation has counterparts in homogenization theory (e.g. mechanics, conductivity, permittivity). | 0 | Theoretical and Fundamental Chemistry |
Marine Chemistry is an international peer-reviewed scientific journal for publications in the field of chemistry in the marine environment. The journal is currently published by Elsevier. Its editor-in-chief is T.S. Bianchi. According to the Journal Citation Reports, Marine Chemistry has a 2020 impact factor of 3.807. | 0 | Theoretical and Fundamental Chemistry |
Kendomycin is an anticancer macrolide first isolated from Streptomyces violaceoruber. It has potent activity as an endothelin receptor antagonist and anti-osteoporosis agent.
It also has strong cytotoxicity against various tumor cell lines. | 0 | Theoretical and Fundamental Chemistry |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.