text
stringlengths 27
1.82k
| relation
stringclasses 4
values | h
dict | t
dict |
|---|---|---|---|
Diuretic actions, heart weight/body weight, heart rate, mean blood pressure, myocardial function by echocardiography, cardiac fibrosis, myocyte diameter and cardiac aldosterone synthetase (CYP11B2) were evaluated.
|
NA
|
{
"id": 1585,
"name": "CYP11B2",
"pos": [
189,
7
]
}
|
{
"id": "C0005910",
"name": "Body Weight",
"pos": [
31,
11
]
}
|
A SAGE tag corresponding to the partial cDNA for the small protein 31 (SMAP31) is upregulated approximately 13-fold in papillary thyroid cancer (PTC) and was selected for further research.
|
NA
|
{
"id": 55511,
"name": "SAGE1",
"pos": [
2,
4
]
}
|
{
"id": "C0238463",
"name": "Papillary thyroid carcinoma",
"pos": [
119,
24
]
}
|
Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines.
|
NA
|
{
"id": 4582,
"name": "MUC1",
"pos": [
14,
4
]
}
|
{
"id": "C0021841",
"name": "Intestinal Neoplasms",
"pos": [
76,
16
]
}
|
This is supported by the rescue of IPD and ISA in D2 eyes with substantially decreased pigment production.
|
NA
|
{
"id": 312,
"name": "ANXA13",
"pos": [
43,
3
]
}
|
{
"id": "C0031911",
"name": "Pigmentation",
"pos": [
87,
7
]
}
|
There is strong evidence from cellular or animal systems that SphK1 is involved in the major mechanisms underpinning oncogenesis, namely, the promotion of cellular survival, proliferation and transformation, the prevention of apoptosis and the stimulation of angiogenesis.
|
biomarker
|
{
"id": 8877,
"name": "SPHK1",
"pos": [
62,
5
]
}
|
{
"id": "C0596263",
"name": "Carcinogenesis",
"pos": [
117,
11
]
}
|
Five of these genes (CDKN1A, GADD45A, PMP22, BEX2, CGREF1, CYR61), were associated with cell cycle arrest and growth regulation and had been previously identified in studies relating muscle wasting and ageing.
|
NA
|
{
"id": 1647,
"name": "GADD45A",
"pos": [
29,
7
]
}
|
{
"id": "C0001811",
"name": "Aging",
"pos": [
202,
6
]
}
|
The data confirmed that FER might play a critical role in the invasion and metastasis of HCC.
|
biomarker
|
{
"id": 2241,
"name": "FER",
"pos": [
24,
3
]
}
|
{
"id": "C1269955",
"name": "Tumor Cell Invasion",
"pos": [
62,
8
]
}
|
Prognostic value of codon 918 (ATG-->ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma.
|
genomic_alterations
|
{
"id": 139818,
"name": "DOCK11",
"pos": [
40,
3
]
}
|
{
"id": "C1833929",
"name": "THYROID CARCINOMA, SPORADIC MEDULLARY",
"pos": [
77,
36
]
}
|
In humans, ATGL has a remarkable effect on cellular lipid droplet handling, and its lack causes both perivisceral, skeletal muscle, and pancreas fat accumulation; in contrast, the impact on whole-body insulin sensitivity and fatty acid metabolism is minor.
|
NA
|
{
"id": 57104,
"name": "PNPLA2",
"pos": [
11,
4
]
}
|
{
"id": "C0920563",
"name": "Insulin Sensitivity",
"pos": [
201,
19
]
}
|
Sphingosine-1-phosphate (S1P) receptor antagonist and sphingosine kinase 1 (SK1) inhibitor FTY720 (FTY) has promising anticancer properties, however, it causes systemic lymphopenia which impairs its use in cancer patients.
|
biomarker
|
{
"id": 8720,
"name": "MBTPS1",
"pos": [
25,
3
]
}
|
{
"id": "C1306459",
"name": "Primary malignant neoplasm",
"pos": [
206,
6
]
}
|
The group 2 LIM domain protein, Cysteine-rich intestinal protein 2 (CRIP2) was found to play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis.
|
biomarker
|
{
"id": 1397,
"name": "CRIP2",
"pos": [
68,
5
]
}
|
{
"id": "C0596263",
"name": "Carcinogenesis",
"pos": [
156,
13
]
}
|
To identify the molecular defect causing gelatinous drop-like corneal dystrophy (GDLD) in two Chinese brothers and report the morphological evaluation of GDLD by laser scanning confocal microscopy and Fourier-domain optical coherence tomography (OCT).
|
NA
|
{
"id": 5362,
"name": "PLXNA2",
"pos": [
246,
3
]
}
|
{
"id": "C0339273",
"name": "Corneal dystrophy, Lattice type 3",
"pos": [
41,
38
]
}
|
We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes.
|
genomic_alterations
|
{
"id": 183,
"name": "AGT",
"pos": [
106,
3
]
}
|
{
"id": "C0010068",
"name": "Coronary heart disease",
"pos": [
41,
3
]
}
|
To investigate the association of 21 polymorphisms within 13 genes, APOE, APOB, APOC3, CETP, LPL, PON1, MTHFR, FGB, F5, GPIIIa, SELE, ACE and AGT, with inter-individual blood pressure (BP) variation.
|
NA
|
{
"id": 1071,
"name": "CETP",
"pos": [
87,
4
]
}
|
{
"id": "C0005823",
"name": "Blood Pressure",
"pos": [
169,
14
]
}
|
Repeated administration of generalized seizures increased levels of beta-catenin immunoreactivity in the subgranular zone of the hippocampus.
|
NA
|
{
"id": 1499,
"name": "CTNNB1",
"pos": [
68,
12
]
}
|
{
"id": "C0234533",
"name": "Generalized seizures",
"pos": [
27,
20
]
}
|
Downstream to GSK-3, a significant reduction in beta-catenin translocation to the nucleus, indicative of impaired Wnt signaling functions, was found as well.
|
NA
|
{
"id": 1499,
"name": "CTNNB1",
"pos": [
48,
12
]
}
|
{
"id": "C0040715",
"name": "Chromosomal translocation",
"pos": [
61,
13
]
}
|
To enable this, we developed a polychromatic antibody cocktail comprising key phenotypic and functional markers of DCs and applied it in a patient cohort from the HTLV-1 endemic region, Jamaica, consisted of seronegative controls, asymptomatic carriers (ACs), ATL, and HAM/TSP patients.
|
NA
|
{
"id": 7057,
"name": "THBS1",
"pos": [
273,
3
]
}
|
{
"id": "C0231221",
"name": "Asymptomatic",
"pos": [
231,
12
]
}
|
We evaluated the performance of two rapid serological tests (PGL1 and NDO-LID) in the discrimination of leprosy cases from healthy individuals at the Alfredo da Matta Foundation, a reference center for the disease in Manaus, Amazonas, Brazil.
|
biomarker
|
{
"id": 6392,
"name": "SDHD",
"pos": [
61,
4
]
}
|
{
"id": "C0023343",
"name": "Leprosy",
"pos": [
104,
7
]
}
|
RESULTS: We found that expression of Dock7, a GEF, is elevated in human GBM tissue in comparison with non-neoplastic brain.
|
NA
|
{
"id": 85440,
"name": "DOCK7",
"pos": [
37,
5
]
}
|
{
"id": "C1709246",
"name": "Non-Neoplastic Disorder",
"pos": [
102,
14
]
}
|
A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication.
|
NA
|
{
"id": 26986,
"name": "PABPC1",
"pos": [
28,
4
]
}
|
{
"id": "C0010823",
"name": "Cytomegalovirus Infections",
"pos": [
112,
15
]
}
|
Besides morphologic changes, hypoxic MHCC97 and Hep3B cells exhibited molecular alterations consistent with epithelial-mesenchymal transition, characterized by the loss of epithelial cell markers (E-cadherin and plakoglobin) and upregulation of mesenchymal markers (vimentin and N-cadherin), as well as the increase of matrix metalloproteinase 2.
|
NA
|
{
"id": 1000,
"name": "CDH2",
"pos": [
279,
10
]
}
|
{
"id": "C0242184",
"name": "Hypoxia",
"pos": [
29,
7
]
}
|
Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling.
|
biomarker
|
{
"id": 406953,
"name": "MIR18A",
"pos": [
32,
12
]
}
|
{
"id": "C0003873",
"name": "Rheumatoid Arthritis",
"pos": [
55,
20
]
}
|
The striking differences in Kidins220 stability resulting from chronic versus acute brain damage may also have important implications for the therapeutic intervention of neurodegenerative disorders.
|
biomarker
|
{
"id": 57498,
"name": "KIDINS220",
"pos": [
28,
9
]
}
|
{
"id": "C0524851",
"name": "Neurodegenerative Disorders",
"pos": [
170,
27
]
}
|
In the phase II TOPARP-A clinical trial, patients with metastatic castrate-resistant prostate cancer who were treated with the PARP inhibitor olaparib lived nearly three times longer without their cancer worsening if their tumors had mutations in at least one of 12 DNA repair genes.
|
genomic_alterations
|
{
"id": 142,
"name": "PARP1",
"pos": [
127,
4
]
}
|
{
"id": "C1328504",
"name": "Hormone refractory prostate cancer",
"pos": [
66,
34
]
}
|
In particular, it is supposable that EGFR-TK inhibitors could cause keratinocytes injury, the release of IL-33 and the consequent interaction with its receptor on mast cells, that induces the secretion of several factors capable to cause skin manifestations, included IL-31, a known pruritus-inducing cytokine.
|
NA
|
{
"id": 1956,
"name": "EGFR",
"pos": [
37,
4
]
}
|
{
"id": "C0033774",
"name": "Pruritus",
"pos": [
283,
8
]
}
|
The regression coefficients obtained for standard curves of AML1-ETO and AML were all greater than 0.98.
|
NA
|
{
"id": 862,
"name": "RUNX1T1",
"pos": [
65,
3
]
}
|
{
"id": "C1836830",
"name": "Developmental regression",
"pos": [
4,
10
]
}
|
We carried out an association study between T-cell receptor beta polymorphism (TCRB) and endometriosis to investigate the difference in allelic frequency.
|
NA
|
{
"id": 6957,
"name": "TRB",
"pos": [
79,
4
]
}
|
{
"id": "C0014175",
"name": "Endometriosis",
"pos": [
89,
13
]
}
|
Two cohorts of patients with RA, the first (n = 97) defined as methotrexate responders (MTX-R) with mild-moderate synovitis, and the second (n = 78) defined as nonresponders to combination therapy and receiving anti-TNF-alpha treatment because of their severe and aggressive disease (TNF-T), were studied retrospectively and compared to age, sex, and ethnically matched controls (n = 84).
|
NA
|
{
"id": 7124,
"name": "TNF",
"pos": [
285,
3
]
}
|
{
"id": "C1513302",
"name": "Mild Adverse Event",
"pos": [
101,
4
]
}
|
Expression of Cyclin E/Cdk2/p27<sup>Kip1</sup> in Growth Hormone Adenomas.
|
genomic_alterations
|
{
"id": 2688,
"name": "GH1",
"pos": [
62,
14
]
}
|
{
"id": "C0001430",
"name": "Adenoma",
"pos": [
77,
8
]
}
|
CONCLUSION: HIF-1α could be considered as an important regulator for the upregulation of survivin gene expression induced by hypoxia in LSCC cells, and both proteins could be regarded as 2 key predictors of malignant progression and metastasis of LSCC.
|
NA
|
{
"id": 3091,
"name": "HIF1A",
"pos": [
12,
6
]
}
|
{
"id": "C0242184",
"name": "Hypoxia",
"pos": [
125,
7
]
}
|
The VEGF receptors, kinase domain region (KDR) and Fms-like-tyrosine kinase (Flt-1), also were upregulated in the tumor vasculature of glioblastoma multiforme, anaplastic oligodendrogliomas, and ependymomas with necrosis, whereas the astrocytomas grade II, anaplastic astrocytomas, and oligodendroglioma tumors tended to express a weak to nondetectable signal.
|
NA
|
{
"id": 3791,
"name": "KDR",
"pos": [
42,
3
]
}
|
{
"id": "C0028945",
"name": "oligodendroglioma",
"pos": [
286,
17
]
}
|
Here, using molecular cytogenetics and molecular biology studies, we comprehensively analyzed four lymphoma cases with non-IG rearrangements of FOXP1 and compared these with cases harboring t(3;14)(p13;q32)/IGH-FOXP1 and FOXP1-expressing lymphomas with no apparent structural aberrations of the gene.
|
NA
|
{
"id": 51013,
"name": "EXOSC1",
"pos": [
198,
3
]
}
|
{
"id": "C0024299",
"name": "Lymphoma",
"pos": [
238,
9
]
}
|
In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients.
|
biomarker
|
{
"id": 574508,
"name": "MIR505",
"pos": [
113,
11
]
}
|
{
"id": "C1275122",
"name": "Familial multiple trichoepitheliomata",
"pos": [
193,
3
]
}
|
Using a clinical oligonucleotide array comparative genomic hybridization (aCGH), we have identified an ∼317 kb hemizygous deletion in 10q24.32, involving PITX3 in a 17-year-old male with a Smith-Magenis syndrome-like phenotype, including mild intellectual impairment, sleep disturbance, hyperactivity, and aggressive and self-destructive behavior.
|
NA
|
{
"id": 5309,
"name": "PITX3",
"pos": [
154,
5
]
}
|
{
"id": "C1513302",
"name": "Mild Adverse Event",
"pos": [
238,
4
]
}
|
Here we compare responses of human glioblastoma-derived neural stem (GNS) cells and genetically normal neural stem (NS) cells to a panel of 160 small molecule kinase inhibitors.
|
NA
|
{
"id": 2799,
"name": "GNS",
"pos": [
69,
3
]
}
|
{
"id": "C0017636",
"name": "Glioblastoma",
"pos": [
35,
12
]
}
|
We have previously demonstrated that IL-22 has critical anti-inflammatory and antiviral roles in mice with coxsackievirus B3 (CVB3)‑induced acute viral myocarditis (AVMC) in the presence of IL-17A.
|
NA
|
{
"id": 53342,
"name": "IL17D",
"pos": [
37,
5
]
}
|
{
"id": "C0276138",
"name": "Viral myocarditis",
"pos": [
146,
17
]
}
|
We used Drosophila melanogaster as a model to investigate the effect of increased HUWE1 levels on the developing nervous system.
|
NA
|
{
"id": 10075,
"name": "HUWE1",
"pos": [
82,
5
]
}
|
{
"id": "C0422837",
"name": "Neurological observations",
"pos": [
113,
14
]
}
|
Hierarchical clustering revealed distinct subgroups, one of which contained 18 (42%) of the CK14+ve tumors.
|
genomic_alterations
|
{
"id": 3861,
"name": "KRT14",
"pos": [
92,
4
]
}
|
{
"id": "C0027651",
"name": "Neoplasms",
"pos": [
100,
6
]
}
|
α-MD-G-stimulated jejunal NHE3 activity was defective in NHERF2-/- mice and cells with NHERF2 knockdown, but occurred normally with NHERF1 knockdown; was associated with increased NHE3 surface expression in Caco-2 cells, which also was NHERF2-dependent; was associated with dissociation of NHE3 from NHERF2 and an increase in the NHE3 mobile fraction from the brush border; and was accompanied by a NHERF2 ezrin-radixin-moesin-binding domain-dependent increase in co-precipitation of ezrin with NHE3.
|
NA
|
{
"id": 9368,
"name": "SLC9A3R1",
"pos": [
132,
6
]
}
|
{
"id": "C0086168",
"name": "Dissociation",
"pos": [
274,
12
]
}
|
We examined the possible association between restriction fragment length polymorphisms in the atrial natriuretic peptide (ANP) gene and responsiveness of aldosterone to angiotensin II in 59 patients with primary aldosteronism due to aldosterone-producing adenoma (APA).
|
NA
|
{
"id": 4878,
"name": "NPPA",
"pos": [
122,
3
]
}
|
{
"id": "C0001430",
"name": "Adenoma",
"pos": [
255,
7
]
}
|
OX40, a costimulatory molecule expressed primarily on activated CD4(+) T cells, promotes and enhances anti-tumor immunity with limited success on large tumors in mice.
|
NA
|
{
"id": 920,
"name": "CD4",
"pos": [
64,
3
]
}
|
{
"id": "C1519680",
"name": "Tumor Immunity",
"pos": [
107,
14
]
}
|
We identified NOX2 as the source of HPV-induced oxidative stress as NOX2 silencing significantly reduced ROS generation, DNA damage and chromosomal aberrations in HPV-positive cells.
|
NA
|
{
"id": 1536,
"name": "CYBB",
"pos": [
14,
4
]
}
|
{
"id": "C0008625",
"name": "Chromosome Aberrations",
"pos": [
136,
23
]
}
|
26 narcoleptic patients with cataplexy, 9 narcoleptic patients without cataplexy, 2 patients with abnormal REM-sleep-associated hypersomnia, 7 patients with idiopathic hypersomnia, 2 patients with post-traumatic hypersomnia, 4 patients with KLS, and 88 patients with other neurological disorders.
|
NA
|
{
"id": 6199,
"name": "RPS6KB2",
"pos": [
241,
3
]
}
|
{
"id": "C0751757",
"name": "Hypersomnolence, Idiopathic",
"pos": [
157,
22
]
}
|
However, the molecular mechanisms by which VIP promotes the androgen-independent growth of androgen-sensitive prostate cancer cells have not been addressed.
|
NA
|
{
"id": 27151,
"name": "CPAMD8",
"pos": [
43,
3
]
}
|
{
"id": "C0376358",
"name": "Malignant neoplasm of prostate",
"pos": [
110,
15
]
}
|
We evaluated the initial untransformed outgrowths (MCF-10MS and MCF-10A) with six transformed cell lines with benign proliferations (MCF-10AT1, MCF-10AT1kcl2), carcinoma in situ (MCF-10CA1h cl13), and invasive carcinoma (MCF-10CA1h cl2, MCF-10CA1a cl1, MCF-10CA1d cl1).
|
NA
|
{
"id": 23266,
"name": "ADGRL2",
"pos": [
232,
3
]
}
|
{
"id": "C1334274",
"name": "Invasive Carcinoma",
"pos": [
201,
18
]
}
|
Our findings suggest that inflammation in the CNS increases in normal aging and is intimately related to markers of neurodegeneration in the preclinical stages of AD and SNAP.
|
NA
|
{
"id": 6616,
"name": "SNAP25",
"pos": [
170,
4
]
}
|
{
"id": "C0001811",
"name": "Aging",
"pos": [
70,
5
]
}
|
Indomethacin and ASA, which suppressed PGE(2) generation both in the non-ulcerated and ulcerated gastric mucosa, significantly delayed the rate of ulcer healing and this was accompanied by the fall in GBF at ulcer margin and further elevation of plasma IL-1beta and TNFalpha levels, which was sustained up to the end of the study.
|
NA
|
{
"id": 1316,
"name": "KLF6",
"pos": [
201,
3
]
}
|
{
"id": "C0041582",
"name": "Ulcer",
"pos": [
208,
5
]
}
|
We studied SF3B1 and DNMT3A in 123 RARS patients: 101 out of 123 samples (82%) had somatic mutations in SF3B1, and 13 of them (13%) showed a co-mutation (SF3B1<sup>mut</sup>DNMT3A<sup>mut</sup>).
|
biomarker
|
{
"id": 1788,
"name": "DNMT3A",
"pos": [
21,
6
]
}
|
{
"id": "C1264195",
"name": "Refractory anemia with ringed sideroblasts",
"pos": [
35,
4
]
}
|
TARC concentrations were higher in SF of RA patients compared to OA patients.
|
biomarker
|
{
"id": 6361,
"name": "CCL17",
"pos": [
0,
4
]
}
|
{
"id": "C0003873",
"name": "Rheumatoid Arthritis",
"pos": [
41,
2
]
}
|
HLA-DRB1 polymorphisms and alopecia areata disease risk: A systematic review and meta-analysis.
|
genomic_alterations
|
{
"id": 3123,
"name": "HLA-DRB1",
"pos": [
0,
8
]
}
|
{
"id": "C0002171",
"name": "Alopecia Areata",
"pos": [
27,
15
]
}
|
CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus.
|
genomic_alterations
|
{
"id": 1029,
"name": "CDKN2A",
"pos": [
120,
5
]
}
|
{
"id": "C0334634",
"name": "Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse",
"pos": [
83,
21
]
}
|
Taken together, we have identified a miRNA signature for GH-producing pituitary tumors and found that miR-26b and miR-128 regulate the activity of the PTEN-AKT pathway in these tumors.
|
NA
|
{
"id": 207,
"name": "AKT1",
"pos": [
156,
3
]
}
|
{
"id": "C0032019",
"name": "Pituitary Neoplasms",
"pos": [
70,
16
]
}
|
OSR1 expression was also significantly down-regulated at both mRNA and protein levels in primary gastric cancer tissues compared with adjacent normal tissues.
|
NA
|
{
"id": 51526,
"name": "OSER1",
"pos": [
0,
4
]
}
|
{
"id": "C0024623",
"name": "Malignant neoplasm of stomach",
"pos": [
97,
14
]
}
|
Indeed, HSS1 hypersensitivity to nuclease digestion strictly correlated with TNFSF6 transcription, including in primary and leukemia T cells.
|
NA
|
{
"id": 284361,
"name": "EMC10",
"pos": [
8,
4
]
}
|
{
"id": "C0023418",
"name": "leukemia",
"pos": [
124,
8
]
}
|
<b>Conclusion:</b> Targeting α7nAChR with PNU-282987 could effectively prevent and treat PH with benefits for preventing ongoing inflammation in the lungs of rats with MCT-induced PH by inhibiting NLRP3 inflammasome activation.
|
biomarker
|
{
"id": 114548,
"name": "NLRP3",
"pos": [
209,
5
]
}
|
{
"id": "C3203102",
"name": "Idiopathic pulmonary arterial hypertension",
"pos": [
101,
2
]
}
|
In addition, transplantation of E14.5 fetal liver (FL) Prep1(i/i) cells into lethally irradiated mice induces lymphomas.
|
NA
|
{
"id": 4863,
"name": "NPAT",
"pos": [
32,
3
]
}
|
{
"id": "C0024299",
"name": "Lymphoma",
"pos": [
110,
9
]
}
|
The primary endpoint was a ≥1/3 reduction in pain (NRS); secondary endpoints included the time to analgesia and adverse effects.
|
NA
|
{
"id": 83985,
"name": "SPNS1",
"pos": [
51,
3
]
}
|
{
"id": "C0027627",
"name": "Neoplasm Metastasis",
"pos": [
57,
9
]
}
|
gr/gr deletions were analyzed by using markers sY1291, sY1191 and sY1197 and by investigating the presence of single nucleotide variants (SNV) in DAZ and CDY1 genes in patients with azoospermia (n = 44), cryptozoospermia (n = 51) or severe oligozoospermia (n = 92).
|
NA
|
{
"id": 1617,
"name": "DAZ1",
"pos": [
146,
3
]
}
|
{
"id": "C3279550",
"name": "Cryptozoospermia",
"pos": [
204,
16
]
}
|
The patient's clinical presentation and history were consistent with pachyonychia congenita (PC), an autosomal dominant genodermatosis caused by mutations in the genes for keratin 6, K6a and K6b; keratin 16, K16; and keratin 17, K17.
|
genomic_alterations
|
{
"id": 3868,
"name": "KRT16",
"pos": [
196,
10
]
}
|
{
"id": "C0265334",
"name": "Pachyonychia Congenita",
"pos": [
69,
22
]
}
|
We found that p53 delivered by adenovirus is poorly expressed in A549 (ARF-null) cells but efficiently expressed in H1299 cells (ARF-positive).
|
NA
|
{
"id": 1029,
"name": "CDKN2A",
"pos": [
129,
3
]
}
|
{
"id": "C0001486",
"name": "Adenovirus Infections",
"pos": [
31,
10
]
}
|
However, minimal or absent expression of the adenovirus serotype 5 (Ad5) receptor CAR (coxsackievirus and adenovirus receptor) on cancer cells represents a major limitation for Ad5-based oncolysis.
|
biomarker
|
{
"id": 10206,
"name": "TRIM13",
"pos": [
82,
3
]
}
|
{
"id": "C0333516",
"name": "Tumor necrosis",
"pos": [
187,
9
]
}
|
Cyclin-dependent kinase-associated protein Cks2 is associated with bladder cancer progression.
|
biomarker
|
{
"id": 1164,
"name": "CKS2",
"pos": [
43,
4
]
}
|
{
"id": "C0005684",
"name": "Malignant neoplasm of urinary bladder",
"pos": [
67,
14
]
}
|
The DRB1*04-DQA1*03 haplotype is a marker of increased SO susceptibility and severity, as in Vogt-Koyanagi-Harada disease, which also has similar clinicopathological and HLA associations.
|
genomic_alterations
|
{
"id": 129831,
"name": "RBM45",
"pos": [
4,
4
]
}
|
{
"id": "C0042170",
"name": "Uveomeningoencephalitic Syndrome",
"pos": [
93,
28
]
}
|
Systolic blood pressure (SBP), diastolic blood pressure (DBP), and anthropometric measurements were obtained from each subject.
|
NA
|
{
"id": 1628,
"name": "DBP",
"pos": [
57,
3
]
}
|
{
"id": "C0428883",
"name": "Diastolic blood pressure",
"pos": [
31,
24
]
}
|
Treatment with irbesartan plus carvedilol reduced the expression of TF and TFPI mRNA and protein after MI in rats, and combined treatment with both agents had greater effects than the single agents alone.
|
therapeutic
|
{
"id": 7035,
"name": "TFPI",
"pos": [
75,
4
]
}
|
{
"id": "C0027051",
"name": "Myocardial Infarction",
"pos": [
103,
2
]
}
|
The 12 RTR with CVD or metabolic complications (RTR+) were more hyperlipidaemic and had higher fibrinogen and VIIc than the 26 RTR free of disease complications (RTR-), or the controls.
|
NA
|
{
"id": 2649,
"name": "NR6A1",
"pos": [
162,
3
]
}
|
{
"id": "C1561955",
"name": "Fibrinogen, CTCAE",
"pos": [
95,
10
]
}
|
Three biotin-dependent enzymes, pyruvate carboxylase (PC), propionyl CoA carboxylase (PCC), and beta-methylcrotonyl CoA carboxylase (beta MCC), were biochemically characterized in fibroblasts from two patients with neonatal multiple carboxylase deficiency.
|
biomarker
|
{
"id": 5091,
"name": "PC",
"pos": [
54,
2
]
}
|
{
"id": "C0268581",
"name": "Holocarboxylase Synthetase Deficiency",
"pos": [
215,
40
]
}
|
In contrast, neoplastic B cells from mantle cell lymphoma (0/11), marginal zone lymphoma (0/12), Burkitt lymphoma (0/3), and grade 1 to 2 follicular lymphoma (0/40) were PD-1 negative.
|
NA
|
{
"id": 5133,
"name": "PDCD1",
"pos": [
170,
4
]
}
|
{
"id": "C1367654",
"name": "Marginal Zone B-Cell Lymphoma",
"pos": [
66,
22
]
}
|
The high specificity and sensitivity of the fibrinogen alpha-chain fragment suggest that it may be a clinical useful tumor marker.
|
NA
|
{
"id": 2217,
"name": "FCGRT",
"pos": [
55,
11
]
}
|
{
"id": "C1561955",
"name": "Fibrinogen, CTCAE",
"pos": [
44,
10
]
}
|
A total of 477 unrelated Caucasian type 2 diabetic patients were recruited according to the following criteria: onset of diabetes after age 35 years, absence of ketonuria at diagnosis, and anti-GAD(-) antibody.
|
NA
|
{
"id": 2571,
"name": "GAD1",
"pos": [
194,
3
]
}
|
{
"id": "C0162275",
"name": "Ketonuria",
"pos": [
161,
9
]
}
|
We confirmed that the JNK pathway is an important regulatory pathway in pancreatic cancer stem cells and further found that JNK inhibition downregulates the decoy receptor DcR1 through IL-8 signaling while upregulating pro-apoptotic death receptors DR4/5, thereby sensitizing cells - even with acquired TRAIL-resistance - to apoptosis induction.
|
biomarker
|
{
"id": 23405,
"name": "DICER1",
"pos": [
172,
4
]
}
|
{
"id": "C0346647",
"name": "Malignant neoplasm of pancreas",
"pos": [
72,
17
]
}
|
To demonstrate the alterations of Protein Kinase C epsilon (PKC epsilon) and components of its signaling complexes after treatment with fosinopril and carvedilol and analyze potential molecular mechanisms of the two drugs for cardiac hypertrophy and heart failure.
|
NA
|
{
"id": 5581,
"name": "PRKCE",
"pos": [
34,
24
]
}
|
{
"id": "C1383860",
"name": "Cardiac Hypertrophy",
"pos": [
226,
19
]
}
|
RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
|
NA
|
{
"id": 2669,
"name": "GEM",
"pos": [
18,
3
]
}
|
{
"id": "C0936223",
"name": "Metastatic Prostate Carcinoma",
"pos": [
32,
26
]
}
|
Mutations in intermediate filament protein genes are responsible for a number of inherited genetic diseases including skin blistering diseases, corneal opacities, and neurological degenerations.
|
NA
|
{
"id": 1674,
"name": "DES",
"pos": [
13,
29
]
}
|
{
"id": "C0010038",
"name": "Corneal Opacity",
"pos": [
144,
17
]
}
|
This is the first study that underscores the direct implication of the NOD2-EGFR axis in IDO1 production and its crucial homeostatic contributions during shigellosis.
|
biomarker
|
{
"id": 64127,
"name": "NOD2",
"pos": [
71,
4
]
}
|
{
"id": "C0013371",
"name": "Shigella Infections",
"pos": [
154,
11
]
}
|
Semiquantitative evaluation by computerised image analysis showed a gradual increased expression of IFN gamma and its corresponding receptor in the convalescent stage of shigellosis.
|
NA
|
{
"id": 3439,
"name": "IFNA1",
"pos": [
100,
3
]
}
|
{
"id": "C0013371",
"name": "Shigella Infections",
"pos": [
170,
11
]
}
|
We are currently screening a pediatric population with hematologic malignancies for mutations in the FANCA, FANCC and FANCG gene, and report here on siblings carrying a heterozygous frameshift mutation in the FANCC Gene.
|
NA
|
{
"id": 2175,
"name": "FANCA",
"pos": [
101,
5
]
}
|
{
"id": "C0376545",
"name": "Hematologic Neoplasms",
"pos": [
55,
24
]
}
|
An exploratory endpoint was the association of Triptocare baseline variables (including TMPRSS2-ERG and PCA3 scores) and PCA3 score at Triptocare last value available with CRPC onset.
|
biomarker
|
{
"id": 7113,
"name": "TMPRSS2",
"pos": [
88,
7
]
}
|
{
"id": "C1328504",
"name": "Hormone refractory prostate cancer",
"pos": [
172,
4
]
}
|
Overall, the present data suggested that ITGB1 upregulation was involved in the regulation of tumorigenesis and disease exacerbation exerted by inflammatory cytokines as IL-6, TGF-β1 and SDF-1, and suggested that targeting ITGB1 and the underlying inflammatory modulator was an attractive strategy for therapeutic intervention during ovarian carcinogenesis.
|
NA
|
{
"id": 3688,
"name": "ITGB1",
"pos": [
223,
5
]
}
|
{
"id": "C0235874",
"name": "Disease Exacerbation",
"pos": [
112,
20
]
}
|
In this study, the mutational screening of an afibrinogenemic Italian male identified the first missense mutation (Met51Arg) in FGA leading to afibrinogenemia.
|
genomic_alterations
|
{
"id": 2243,
"name": "FGA",
"pos": [
128,
3
]
}
|
{
"id": "C0001733",
"name": "Afibrinogenemia",
"pos": [
143,
15
]
}
|
An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples.
|
biomarker
|
{
"id": 4853,
"name": "NOTCH2",
"pos": [
54,
6
]
}
|
{
"id": "C0017638",
"name": "Glioma",
"pos": [
64,
6
]
}
|
Thus, the phenotype of MADA can be manifest in preschool age; diagnosis may be suggested by short and bulbous fingertips, facial features, and lipodystrophy, supported by the finding of acral osteolysis, and confirmed by mutation analysis.
|
NA
|
{
"id": 270,
"name": "AMPD1",
"pos": [
23,
4
]
}
|
{
"id": "C4721411",
"name": "Osteolysis",
"pos": [
192,
10
]
}
|
Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK?
|
NA
|
{
"id": 238,
"name": "ALK",
"pos": [
112,
3
]
}
|
{
"id": "C0040715",
"name": "Chromosomal translocation",
"pos": [
54,
13
]
}
|
Rare cases of t(X;6)(p11;q23) translocation have been described but these were sporadic.
|
NA
|
{
"id": 8909,
"name": "ENDOU",
"pos": [
21,
3
]
}
|
{
"id": "C0040715",
"name": "Chromosomal translocation",
"pos": [
30,
13
]
}
|
Multivariable logistic regression analysis limited to only predictors available preoperatively (molecular markers, age, sex, and tumor size) found miR-146b-3p, miR-146b-5p, miR-222, and BRAF(V600E) mutation to predict CLNM independently.
|
genomic_alterations
|
{
"id": 673,
"name": "BRAF",
"pos": [
186,
4
]
}
|
{
"id": "C0027651",
"name": "Neoplasms",
"pos": [
129,
5
]
}
|
Animal studies indicate that the drugs most likely to cause weight gain, clozapine and olanzapine, have direct effects on the NPY-containing neurons of the hypothalamus; these neurons mediate the effects of the circulating anorexigenic hormone leptin on the control of food intake.
|
NA
|
{
"id": 4852,
"name": "NPY",
"pos": [
126,
3
]
}
|
{
"id": "C0043094",
"name": "Weight Gain",
"pos": [
60,
11
]
}
|
Two SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-cholesterol level (Ile405Val P = < .0001; Cys112Arg P = 0.001) and with the prevalence of abdominal obesity (Ile405Val P = 0.007; Cys112Arg P = 0.007).
|
genomic_alterations
|
{
"id": 348,
"name": "APOE",
"pos": [
29,
4
]
}
|
{
"id": "C0028754",
"name": "Obesity",
"pos": [
200,
7
]
}
|
Gene silencing of AFTPH enhanced NT-induced proinflammatory responses and AFTPH levels were downregulated in experimental colitis.
|
NA
|
{
"id": 54812,
"name": "AFTPH",
"pos": [
74,
5
]
}
|
{
"id": "C0009319",
"name": "Colitis",
"pos": [
122,
7
]
}
|
Our investigations revealed an increased localization of p27(kip1) in the cytoplasm of CD34(+) cells in the blast phase compared to chronic phase.
|
NA
|
{
"id": 10671,
"name": "DCTN6",
"pos": [
57,
3
]
}
|
{
"id": "C0005699",
"name": "Blast Phase",
"pos": [
108,
11
]
}
|
The authors report two novel mutations confirming that GAN is caused by mutations in the gigaxonin gene and raise the question whether some mutations may cause a mild subclinical neuropathy.
|
NA
|
{
"id": 8139,
"name": "GAN",
"pos": [
89,
14
]
}
|
{
"id": "C1513302",
"name": "Mild Adverse Event",
"pos": [
162,
4
]
}
|
Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility.
|
NA
|
{
"id": 80332,
"name": "ADAM33",
"pos": [
98,
6
]
}
|
{
"id": "C2717792",
"name": "Airway Remodeling",
"pos": [
41,
17
]
}
|
EGFRvIII-expressing or EGF-stimulated human GBM cells increased expression, phosphorylation, and cytosolic translocation of MARCKS in a protein kinase C-alpha-dependent manner.
|
NA
|
{
"id": 4082,
"name": "MARCKS",
"pos": [
124,
6
]
}
|
{
"id": "C0040715",
"name": "Chromosomal translocation",
"pos": [
107,
13
]
}
|
Reporter assay, glutathione-S-transferase pull-down assay, adenovirus-mediated gene transduction, and chromatin immunoprecipitation assay were used to study the mechanism of TGFbeta1 regulation of CYP7A1 gene transcription.
|
NA
|
{
"id": 1581,
"name": "CYP7A1",
"pos": [
197,
11
]
}
|
{
"id": "C0001486",
"name": "Adenovirus Infections",
"pos": [
59,
10
]
}
|
Misdiagnosis of phosphatase and tensin homologue hamartoma syndromes is common.
|
NA
|
{
"id": 7145,
"name": "TNS1",
"pos": [
32,
6
]
}
|
{
"id": "C0018552",
"name": "Hamartoma",
"pos": [
49,
9
]
}
|
This study was aimed to evaluate the role of MSP in alveolar macrophages (AM) isolated from healthy volunteers and patients with interstitial lung diseases (sarcoidosis, idiopathic pulmonary fibrosis), either smokers or non-smokers, by evaluating the respiratory burst, cytokine release and nuclear factor-kappa B (NF-kappaB) activation.
|
NA
|
{
"id": 89782,
"name": "LMLN",
"pos": [
45,
3
]
}
|
{
"id": "C1800706",
"name": "Idiopathic Pulmonary Fibrosis",
"pos": [
170,
29
]
}
|
Moreover, by fluorescence microscopy we demonstrated that Gal1 promoted glycan-dependent heterotypic adhesion of HepG2 cells to SK-HEP-1 SECs.
|
NA
|
{
"id": 3956,
"name": "LGALS1",
"pos": [
58,
4
]
}
|
{
"id": "C0001511",
"name": "Tissue Adhesions",
"pos": [
101,
8
]
}
|
Structural, and numeric chromosome aberrations (CA), sister-chromatid exchange (SCE), phytohemagglutinin stimulation (LI), proliferative rate index (PRI), and UV light-induced unscheduled DNA-synthesis (UDS) were investigated in peripheral blood lymphocytes (PBL) of 48 historical controls ("Controls"); of 14 hospital controls in Budapest, Hungary ("Budapest controls"); of 9 nurses occupationally exposed to low-dose ethylene-oxide in Budapest ("Budapest exposed"); of 10 hospital controls in Eger, Hungary ("Eger controls"); and of 27 high dose ETO-exposed nurses in Eger ("Eger exposed"), where neoplasias, mainly breast cancers, were observed.
|
NA
|
{
"id": 862,
"name": "RUNX1T1",
"pos": [
548,
3
]
}
|
{
"id": "C0008625",
"name": "Chromosome Aberrations",
"pos": [
24,
22
]
}
|
Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines.
|
biomarker
|
{
"id": 92737,
"name": "DNER",
"pos": [
23,
3
]
}
|
{
"id": "C2145472",
"name": "Urothelial Carcinoma",
"pos": [
91,
20
]
}
|
Our findings clearly indicate that, Ox-LDL significantly induced lincRNA-DYNLRB2-2 expression, which promoted ABCA1-mediated cholesterol efflux and inhibited inflammation through GPR119 in THP-1 macrophage-derived foam cells.
|
NA
|
{
"id": 19,
"name": "ABCA1",
"pos": [
110,
5
]
}
|
{
"id": "C4281786",
"name": "Presence of foam cells",
"pos": [
214,
10
]
}
|
Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (825C -> T in the G protein beta3 subunit gene and 190G -> A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G -> A in the tumor necrosis factor- alpha gene) was significantly associated with hypertension in women.
|
NA
|
{
"id": 27319,
"name": "BHLHE22",
"pos": [
234,
5
]
}
|
{
"id": "C0020443",
"name": "Hypercholesterolemia",
"pos": [
134,
20
]
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.