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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother.
- A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnionitis from 2,051 deliveries at University Hospital, Newark, from January 2003 to July 2003. Third-trimester placentas without histologic chorioamnionitis (n = 52) served as controls. Cases and controls were selected sequentially. Maternal medical records were reviewed for indicators of maternal infection.
- Histologic chorioamnionitis was significantly associated with the usage of antibiotics (p = 0.0095) and a higher mean white blood cell count (p = 0.018). The presence of 1 or more clinical indicators was significantly associated with the presence of histologic chorioamnionitis (p = 0.019).
Question: Does histologic chorioamnionitis correspond to clinical chorioamnionitis?
Options:
A. yes
B. no
C. maybe
| Histologic chorioamnionitis is a reliable indicator of infection whether or not it is clinically apparent. The answer is: A | A | Does histologic chorioamnionitis correspond to clinical chorioamnionitis? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Complex regional pain syndrome type I is treated symptomatically. A protective effect of vitamin C (ascorbic acid) has been reported previously. A dose-response study was designed to evaluate its effect in patients with wrist fractures.
- In a double-blind, prospective, multicenter trial, 416 patients with 427 wrist fractures were randomly allocated to treatment with placebo or treatment with 200, 500, or 1500 mg of vitamin C daily for fifty days. The effect of gender, age, fracture type, and cast-related complaints on the occurrence of complex regional pain syndrome was analyzed.
- Three hundred and seventeen patients with 328 fractures were randomized to receive vitamin C, and ninety-nine patients with ninety-nine fractures were randomized to receive a placebo. The prevalence of complex regional pain syndrome was 2.4% (eight of 328) in the vitamin C group and 10.1% (ten of ninety-nine) in the placebo group (p=0.002); all of the affected patients were elderly women. Analysis of the different doses of vitamin C showed that the prevalence of complex regional pain syndrome was 4.2% (four of ninety-six) in the 200-mg group (relative risk, 0.41; 95% confidence interval, 0.13 to 1.27), 1.8% (two of 114) in the 500-mg group (relative risk, 0.17; 95% confidence interval, 0.04 to 0.77), and 1.7% (two of 118) in the 1500-mg group (relative risk, 0.17; 95% confidence interval, 0.04 to 0.75). Early cast-related complaints predicted the development of complex regional pain syndrome (relative risk, 5.35; 95% confidence interval, 2.13 to 13.42).
Question: Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures?
Options:
A. yes
B. no
C. maybe
| Vitamin C reduces the prevalence of complex regional pain syndrome after wrist fractures. A daily dose of 500 mg for fifty days is recommended. The answer is: A | A | Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Fournier's gangrene is known to have an impact in the morbidity and despite antibiotics and aggressive debridement, the mortality rate remains high.
- To assess the morbidity and mortality in the treatment of Fournier's gangrene in our experience.
- The medical records of 14 patients with Fournier's gangrene who presented at the University Hospital Center "Mother Teresa" from January 1997 to December 2006 were reviewed retrospectively to analyze the outcome and identify the risk factor and prognostic indicators of mortality.
- Of the 14 patients, 5 died and 9 survived. Mean age was 54 years (range from 41-61): it was 53 years in the group of survivors and 62 years in deceased group. There was a significant difference in leukocyte count between patients who survived (range 4900-17000/mm) and those died (range 20.300-31000/mm3). Mean hospital stay was about 19 days (range 2-57 days).
Question: It's Fournier's gangrene still dangerous?
Options:
A. yes
B. no
C. maybe
| The interval from the onset of clinical symptoms to the initial surgical intervention seems to be the most important prognostic factor with a significant impact on outcome. Despite extensive therapeutic efforts, Fournier's gangrene remains a surgical emergency and early recognition with prompt radical debridement is the mainstays of management. The answer is: A | A | It's Fournier's gangrene still dangerous? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to analyze the properties of the immune cell microenvironment of regional lymph nodes (LNs) positive for lung cancer.
- Twenty-four patients operated on for stages T1 and T2 of the NSCLC, were enrolled in the study. Peripheral blood and LN tissue were obtained from different lymph node sites and levels. As a control, LN tissue was taken from patients diagnosed with emphysema or pneumothorax. The cells from randomly chosen LN were tested by multi-color flow cytometry. Separate portions of LN were snap-frozen and examined for the presence of cytokeratin positive cells (CK). Propensity for apoptosis, level of TCR zeta chain expression of T cells and the number and maturation status of dendritic cells were confronted with the presence of CK-positive cells.
- The presence of metastases correlated with the downregulation of TCR zeta, especially CD8(+) T cells. The most striking feature was the reduction in the number of myeloid CD11c(+) dendritic cells in the LN of patients with LN metastases. This could be a reflection of the immunodeficient state observed in lung cancer patients. Even in the absence of metastases in the regional LN, the same type of changes in the LN microenvironment were observed in those LN located nearer the primary tumor.
Question: Can the condition of the cell microenvironment of mediastinal lymph nodes help predict the risk of metastases in non-small cell lung cancer?
Options:
A. yes
B. no
C. maybe
| The preliminary results of this study suggest that this approach may be helpful as an independent tumor staging factor. It is also worth noting that part of the staging process could also be based on features describing the immune cells in the peripheral blood. The answer is: A | A | Can the condition of the cell microenvironment of mediastinal lymph nodes help predict the risk of metastases in non-small cell lung cancer? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome.
- Between 1976 and 2008, 569 pancreas transplantations were performed in Lyon and Geneva, including 37 second transplantations. Second graft survival was compared with primary graft survival of the same patients and the whole population. Predictive factors of second graft survival were sought. Patient survival and impact on kidney graft function and survival were evaluated.
- Second pancreas survival of the 17 patients transplanted from 1995 was close to primary graft survival of the whole population (71% vs. 79% at 1 year and 59% vs. 69% at 5 years; P=0.5075) and significantly better than their first pancreas survival (71% vs. 29% at 1 year and 59% vs. 7% at 5 years; P=0.0008) regardless of the cause of first pancreas loss. The same results were observed with all 37 retransplantations. Survival of second simultaneous pancreas and kidney transplantations was better than survival of second pancreas after kidney. Patient survival was excellent (89% at 5 years). Pancreas retransplantation had no impact on kidney graft function and survival (100% at 5 years).
Question: Pancreas retransplantation: a second chance for diabetic patients?
Options:
A. yes
B. no
C. maybe
| Pancreas retransplantation is a safe procedure with acceptable graft survival that should be proposed to diabetic patients who have lost their primary graft. The answer is: A | A | Pancreas retransplantation: a second chance for diabetic patients? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- It remains controversial whether there is a gender difference in survival of patients with resected non-small cell lung cancer.
- We retrospectively analyzed 2770 patients (1689 men and 1081 women) with non-small cell lung cancer who underwent pulmonary resection between 1995 and 2005 at the National Cancer Center Hospital, Tokyo. A gender difference in survival was studied in all patients, in those divided according to histology or pathologic stage, and in propensity-matched gender pairs.
- There were no differences in background, such as preoperative pulmonary function, operation procedures, or operative mortality. The proportions of adenocarcinoma and pathologic stage I in women were greater than those in men (93.6% vs 61.7% and 71.4% vs 58.6%, respectively) (P<.001). Overall 5-year survival of women was better than that of men (81% vs 70%, P<.001). In adenocarcinoma, the overall 5-year survival for women was better than that for men in pathologic stage I (95% vs 87%, P<.001) and in pathologic stage II or higher (58% vs 51%, P = .017). In non-adenocarcinoma, there was no significant gender difference in survival in pathologic stage I (P = .313) or pathologic stage II or higher (P = .770). The variables such as age, smoking status, histology, and pathologic stage were used for propensity score matching, and survival analysis of propensity score-matched gender pairs did not show a significant difference (P = .69).
Question: Gender difference in survival of resected non-small cell lung cancer: histology-related phenomenon?
Options:
A. yes
B. no
C. maybe
| Women had better survival than men; however, there was no survival advantage in propensity-matched gender pairs. A gender difference in survival was observed only in the adenocarcinoma subset, suggesting pathobiology in adenocarcinoma in women might be different from that of men. The answer is: A | A | Gender difference in survival of resected non-small cell lung cancer: histology-related phenomenon? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To assess the impact of the comprehensive HIV/STD Control Program established in Jamaica since the late 1980s on the HIV/AIDS epidemic.
- AIDS case reports, HIV testing of blood donors, antenatal clinic attenders (ANC), food service workers, sexually transmitted disease (STD) clinic attenders, female prostitutes, homosexuals and other groups were used to monitor the HIV/AIDS epidemic. Primary and secondary syphilis and cases of congenital syphilis were also monitored. National knowledge, attitude and practice (KAP) surveys were conducted in 1988, 1989, 1992, 1994 and 1996.
- The annual AIDS incidence rate in Jamaica increased only marginally in the past three years from 18.5 per 100000 population to 21.4 in 1997. HIV prevalence in the general population groups tested has been about 1% or less. Among those at high risk, HIV prevalence rates have risen to 6.3% (95% confidence interval 5.0-8.0) in STD clinic attenders, around 10% and 21% in female prostitutes in Kingston and Montego Bay respectively and approximately 30% among homosexuals. Syphilis rates and congenital syphilis cases have declined. The proportion of men aged 15-49 years reporting sex with a non-regular partner declined from 35% in 1994 to 26% in 1996 (P<0.001). Women ever having used condoms increased from 51% in 1988 to 62.5% in 1992 and 73% in 1994 and 1996 (P<0.001), while condom use with a non-regular partner increased from 37% in 1992 to 73% in 1996 (P= 0.006). Condom use among men was high over the period: around 81% had ever used condoms and 77% used them with non-regular partners. Gay men, inner-city adults and adolescents aged 12-14 years all reported increases in condom use while condom sales and distribution increased from around 2 million in 1985 to 10 million in 1995.
Question: Is HIV/STD control in Jamaica making a difference?
Options:
A. yes
B. no
C. maybe
| HIV/STD control measures appear to have slowed the HIV/AIDS epidemic in Jamaica, however a significant minority of persons continue to have unprotected sex in high risk situations. The answer is: A | A | Is HIV/STD control in Jamaica making a difference? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to evaluate poststapedectomy-delayed facial palsy etiopathogenesis, risk factors, evolution, and prevention.
- Seven hundred six stapedectomies performed in 580 patients were reviewed. In all patients who developed delayed facial palsy, the dates of onset and subside of facial palsy, the anatomic and pathologic predisposing factors, and a possible history for recurrent labial herpetic lesions were considered. The House-Brackmann (H-B) grading system was used to evaluate the facial function. Virus-specific immunoglobulin (Ig) G and IgM antibodies against herpes simplex virus type 1 (HSV-1) were determined by enzyme-linked immunosorbent assay (ELISA) 3 weeks after the onset of the paralysis. The results were compared with a control group without a history of recurrent herpes labialis.
- Poststapedectomy facial palsy developed in 7 out of 706 procedures. All 7 patients referred a history of recurrent labial herpetic lesions. One patient showed a facial palsy H-B grade II, 2 a grade III, and 3 a grade IV. After acyclovir therapy, 6 subjects recovered completely, whereas 1 maintained an H-B grade II. An increased IgG antibody titer was found in 6 of the patients with delayed facial palsy and in 1 out of 7 controls. Mean IgG titer was 1:14,050 in the subjects with delayed facial palsy and 1:2,300 in controls (P<.001).
Question: Delayed peripheral facial palsy in the stapes surgery: can it be prevented?
Options:
A. yes
B. no
C. maybe
| Poststapedectomy-delayed facial palsy is likely caused by a reactivation of HSV-1, latent within the geniculate ganglion. The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy. The answer is: A | A | Delayed peripheral facial palsy in the stapes surgery: can it be prevented? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Gallbladder carcinoma is characterized by delayed diagnosis, ineffective treatment and poor prognosis. Surgical resection has been thought to be the treatment of choice, while the role of radiotherapy as adjuvant or palliative treatment has not been fully clarified in the literature.
- We present the case of a 45-year-old female, with unresectable gallbladder carcinoma, grade IV, histologically diagnosed during laparotomy. The patient was treated with palliative intent with percutaneous transhepatic biliary drainage. Furthermore, she received external radiotherapy by (60)Co, using a three-field technique (anterior-posterior and right lateral). The total dose was 3,000 cGy in 10 fractions, with 300 cGy per fraction, 5 days weekly.
- The patient showed clinico-laboratory improvement and was discharged with a permanent percutaneous transhepatic endoprosthesis. During follow-up (10 and 12 months postirradiation), abdominal CTs showed no local extension of the tumor, while the patient had a good performance status. So far, 1 year after the diagnosis of gallbladder cancer she is still alive.
Question: Is external palliative radiotherapy for gallbladder carcinoma effective?
Options:
A. yes
B. no
C. maybe
| External radiotherapy seems to be a safe and effective method of palliative management of gallbladder carcinoma. However, further studies are necessary to determine the role of radiotherapy in palliative or adjuvant treatment of gallbladder carcinoma. The answer is: A | A | Is external palliative radiotherapy for gallbladder carcinoma effective? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The purpose of this study was to evaluate the value of elevated cardiac troponin I (cTnI) for prediction of complicated clinical course and in-hospital mortality in patients with confirmed acute pulmonary embolism (PE).
- This study was a retrospective chart review of patients diagnosed as having PE, in whom cTnI testing was obtained at emergency department (ED) presentation between January 2002 and April 2006. Clinical characteristics; echocardiographic right ventricular dysfunction; inhospital mortality; and adverse clinical events including need for inotropic support, mechanical ventilation, and thrombolysis were compared in patients with elevated cTnI levels vs patients with normal cTnI levels. One hundred sixteen patients with PE were identified, and 77 of them (66%) were included in the study. Thirty-three patients (42%) had elevated cTnI levels. Elevated cTnI levels were associated with inhospital mortality (P = .02), complicated clinical course (P<.001), and right ventricular dysfunction (P<.001). In patients with elevated cTnI levels, inhospital mortality (odds ratio [OR], 3.31; 95% confidence interval [CI], 1.82-9.29), hypotension (OR, 7.37; 95% CI, 2.31-23.28), thrombolysis (OR, 5.71; 95% CI, 1.63-19.92), need for mechanical ventilation (OR, 5.00; 95% CI, 1.42-17.57), and need for inotropic support (OR, 3.02; 95% CI, 1.03-8.85) were more prevalent. The patients with elevated cTnI levels had more serious vital parameters (systolic blood pressure, pulse, and oxygen saturation) at ED presentation.
Question: Can elevated troponin I levels predict complicated clinical course and inhospital mortality in patients with acute pulmonary embolism?
Options:
A. yes
B. no
C. maybe
| Our results indicate that elevated cTnI levels are associated with higher risk for inhospital mortality and complicated clinical course. Troponin I may play an important role for the risk assessment of patients with PE. The idea that an elevation in cTnI levels is a valuable parameter for the risk stratification of patients with PE needs to be examined in larger prospective studies. The answer is: A | A | Can elevated troponin I levels predict complicated clinical course and inhospital mortality in patients with acute pulmonary embolism? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- This study aims to evaluate the efficacy of closed reduction and the effects of timing and fracture types on patient satisfaction.
- Only patients with isolated nasal fractures were included in the study. Patients with additional maxillofacial fractures and patients whose application time to our clinic was more than 10 days after the trauma were excluded. Patients were classified into 5 types according to their fracture. All patients underwent closed reduction and external fixation under local anesthesia. Patients were asked about their satisfaction in a survey at 28th day and sixth month after the surgery. Patients were divided into groups according to fracture type and intervention time, and the results of the survey were evaluated.
- Of the 43 patients included in the study, 38 were male, 5 were female, and the average age was 24.9. The average intervention time of the patients was 5.44 days. Twenty-eight (65%) of 43 patients were satisfied with the result, whereas 15 (35%) patients were not happy with their operation. In a comparison of patient satisfaction rates according to fracture type, the mild fracture group had a higher satisfaction rate compared to the severe fracture group.
Question: Nasal fractures: is closed reduction satisfying?
Options:
A. yes
B. no
C. maybe
| Closed reduction is an easy and sufficient treatment for nasal fractures, especially for mild nasal fractures. Early intervention raises the patient satisfaction rate. The answer is: A | A | Nasal fractures: is closed reduction satisfying? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To compare children's, parents' and physicians' perceptions of children's body size.
- We administered a structured questionnaire of body size perception using a descriptive Likert scale keyed to body image figures to children ages 12 to 18 years. The same scale was given to parents of children ages 5 to 18 years. The sample consisted of 91 children and their parents being seen in the Pediatric Gastroenterology Clinic for concerns unrelated to overweight. Weight and height of the children were measured, and body mass index (BMI) was calculated. The children's BMI percentiles were categorized as underweight (<15th), normal (15th-85th), overweight (85th-95th), and obese (95th and above). The attending physician independently completed the body image and description scale and indicated the figure that most accurately represented the patient without reference to BMI standards. Accuracy of the patients', parents', and doctors' estimates were statistically compared.
- The sample population consisted of 6.4% underweight, 70.5% normal weight, 7.7% overweight, and 15.4% obese. Forty-four percent of parents underestimated children's body size using word descriptions and 47% underestimated using figures. Forty percent of the children underestimated their own body size using descriptions and 43% underestimated using figures. The physicians in this study had a higher percentage of correct estimates; however, they underestimated 33% of the patients using both word descriptions and figures. Some obese children were not recognized, and several average children were perceived as underweight.
Question: Body perception: do parents, their children, and their children's physicians perceive body image differently?
Options:
A. yes
B. no
C. maybe
| Many children underestimated their degree of overweight. Their parents and even their attending physicians shared this misperception. This study demonstrates the need to further educate physicians to recognize obesity and overweight so that they can counsel children and their families. The answer is: A | A | Body perception: do parents, their children, and their children's physicians perceive body image differently? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To describe clinical characteristics of oral mucoceles/ranulas, with a focus on human immunodeficiency virus (HIV)-related salivary gland diseases.
- A descriptive and clinical study, with review of patient data.
- We reviewed 113 referred cases of oral mucocele. The following anatomical sites were identified: lip, tongue, and floor of the mouth (simple ranulas), as well as plunging ranulas. The age and gender data of the patients with oral mucoceles were recorded. The HIV status of the patients and other information were reviewed.
- There were 30 (26.5%) males and 83 (73.5%) females. Most patients were below 30 years of age, with the peak frequency in the first and second decade. Ranula (simple and plunging) represented 84.1% of the mucocele locations. Mucocele on the lips represented 10.6%. Seventy-two (63.7%) patients were HIV positive; and 97.2% of them had ranulas. Thirty-eight (33.6%) patients presented with plunging ranulas; and 92.1% of them were HIV positive, compared with two patients presenting with plunging ranulas in the HIV-negative group. These results strongly suggest that an HIV-positive patient is statistically (P<0.001) more at risk of presenting with not only a simple, but also a plunging ranula type.
Question: Oral mucocele/ranula: Another human immunodeficiency virus-related salivary gland disease?
Options:
A. yes
B. no
C. maybe
| This study presents a different clinical picture of oral mucoceles/ranulas, as observed in HIV-positive patients. Additionally, it suggests a possible clinical link between the two pathologies. The authors strongly support the suggestion that oral mucocele/ranula is an HIV-related salivary gland disease. The answer is: A | A | Oral mucocele/ranula: Another human immunodeficiency virus-related salivary gland disease? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate the usefulness of half-dose contrast-enhanced magnetic resonance (MR) angiography for depicting the abdominal aorta and its major branches.
- A total of 72 consecutive patients were randomly assigned to one of four groups that underwent MR angiography after receiving different concentrations (original or diluted to 50%) and total amounts (single or half-dose) of gadolinium chelate injected at different rates (1 or 0.5 mL/second). The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the abdominal aorta and of the common and external iliac arteries were calculated, and two blinded readers rated the respective image qualities.
- The SNR and CNR of the abdominal aorta and the common iliac artery in the 0.5 mL/second groups were statistically significantly lower than those in the 1 mL/second groups. The differences in overall image quality across the four groups were not statistically significant.
Question: Is half-dose contrast-enhanced three-dimensional MR angiography sufficient for the abdominal aorta and pelvis?
Options:
A. yes
B. no
C. maybe
| Half-dose MR angiography using diluted contrast medium injected at a rate of 1 mL/second depicted the abdominal aorta and its branches as clearly as using a full single dose. The answer is: A | A | Is half-dose contrast-enhanced three-dimensional MR angiography sufficient for the abdominal aorta and pelvis? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate the effects of insulin 30/70 twice daily or bedtime isophane (NPH) insulin plus continued sulfonylurea and metformin in patients with type 2 diabetes in primary care.
- Open-label, randomized trial.
- Persons younger than 76 years with type 2 diabetes whose disease had not been controlled with oral hypoglycemic agents alone. A total of 64 insulin-naive patients treated with maximal feasible dosages of sulfonylurea and metformin (baseline glycosylated hemoglobin [HbA1c]=8.5%) were randomly assigned to insulin monotherapy (IM group; n=31) or insulin in addition to unchanged oral hypoglycemic medication (IC group; n=33) for 12 months. Insulin doses were adjusted to obtain fasting glucose<7.0 mmol/L and postprandial glucose<10.0 mmol/L.
- Outcome measures included HbA1c, treatment failure, weight, hypoglycemic events and symptoms, satisfaction with treatment, general well-being, and fear of injecting insulin and testing.
- HbA1c improved from 8.3% to 7.6% in the IC group, and from 8.8% to 7.6% in the IM group (P=NS). The IC group had 24% treatment failures, compared with 2% in the IM group (P=.09). Patients in the IC group had less weight gain than those in the IM group (1.3 vs 4.2 kg; P=.01), and they reported fewer hypoglycemic events (2.7 vs 4.3; P=.02). Increased satisfaction with treatment was equal in the 2 groups, and general well-being improved by 3.0 points more in the IC group (P=.05). Fear of self-injecting and self-testing did not differ.
Question: Starting insulin in type 2 diabetes: continue oral hypoglycemic agents?
Options:
A. yes
B. no
C. maybe
| Bedtime NPH insulin added to maximal therapy with sulfonylurea and metformin is an effective, simple, well-tolerated approach for patients with uncontrolled type 2 diabetes. The answer is: A | A | Starting insulin in type 2 diabetes: continue oral hypoglycemic agents? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The impact of different strategies for management of intercostal and lumbar arteries during repair of thoracic and thoracoabdominal aortic aneurysms (TAA/A) on the prevention of paraplegia remains poorly understood.
- One hundred consecutive patients with intraoperative monitoring of motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP) during TAA/A repair involving serial segmental artery sacrifice (October 2002 to December 2004) were reviewed.
- Operative mortality was 6%. The median intensive care unit stay was 2.5 days (IQ range: 1-4 days), and the median hospital stay 10.0 days (IQ range: 8-17 days). Potentials remained unchanged during the course of serial segmental artery sacrifice, or could be returned to baseline levels by anesthetic and blood pressure manipulation, in 99 of 100 cases. An average of 8.0 +/- 2.6 segmental artery pairs were sacrificed overall, with an average of 4.5 +/- 2.1 segmental pairs sacrificed between T7 and L1, where the artery of Adamkiewicz is presumed to arise. Postoperative paraplegia occurred in 2 patients. In 1, immediate paraplegia was precipitated by an intraoperative dissection, resulting in 6 hours of lower body ischemia. A second ambulatory patient had severe paraparesis albeit normal cerebral function after resuscitation from a respiratory arrest.
Question: Thoracic and thoracoabdominal aneurysm repair: is reimplantation of spinal cord arteries a waste of time?
Options:
A. yes
B. no
C. maybe
| With monitoring of MEP and SSEP, sacrifice--without reimplantation--of as many as 15 intercostal and lumbar arteries during TAA/A repair is safe, resulting in acceptably low rates of immediate and delayed paraplegia. This experience suggests that routine surgical implantation of segmental vessels is not indicated, and that, with evolving understanding of spinal cord perfusion, endovascular repair of the entire thoracic aorta should ultimately be possible without spinal cord injury. The answer is: A | A | Thoracic and thoracoabdominal aneurysm repair: is reimplantation of spinal cord arteries a waste of time? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- We have previously reported the feasibility of diagnostic and therapeutic peritoneoscopy including liver biopsy, gastrojejunostomy, and tubal ligation by an oral transgastric approach. We present results of per-oral transgastric splenectomy in a porcine model. The goal of this study was to determine the technical feasibility of per-oral transgastric splenectomy using a flexible endoscope.
- We performed acute experiments on 50-kg pigs. All animals were fed liquids for 3 days prior to procedure. The procedures were performed under general anesthesia with endotracheal intubation. The flexible endoscope was passed per orally into the stomach and puncture of the gastric wall was performed with a needle knife. The puncture was extended to create a 1.5-cm incision using a pull-type sphincterotome, and a double-channel endoscope was advanced into the peritoneal cavity. The peritoneal cavity was insufflated with air through the endoscope. The spleen was visualized. The splenic vessels were ligated with endoscopic loops and clips, and then mesentery was dissected using electrocautery.
- Endoscopic splenectomy was performed on six pigs. There were no complications during gastric incision and entrance into the peritoneal cavity. Visualization of the spleen and other intraperitoneal organs was very good. Ligation of the splenic vessels and mobilization of the spleen were achieved using commercially available devices and endoscopic accessories.
Question: Transgastric endoscopic splenectomy: is it possible?
Options:
A. yes
B. no
C. maybe
| Transgastric endoscopic splenectomy in a porcine model appears technically feasible. Additional long-term survival experiments are planned. The answer is: A | A | Transgastric endoscopic splenectomy: is it possible? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Arterial calcification is a significant cardiovascular risk factor in hemodialysis patients. A series of factors are involved in the process of arterial calcification; however, the relationship between malnutrition and arterial calcification is still unclear.
- 68 hemodialysis patients were enrolled in this study. Nutrition status was evaluated using modified quantitative subjective global assessment (MQSGA). Related serum biochemical parameters were measured. And the radial artery samples were collected during the arteriovenous fistula surgeries. Hematoxylin/eosin stain was used to observe the arterial structures while Alizarin red stain to observe calcified depositions and classify calcified degree. The expressions of bone morphogenetic protein 2 (BMP2) and matrix Gla protein (MGP) were detected by immunohistochemistry and western blot methods.
- 66.18% hemodialysis patients were malnutrition. In hemodialysis patients, the calcified depositions were mainly located in the medial layer of the radial arteries and the expressions of BMP2 and MGP were both increased in the calcified areas. The levels of serum albumin were negatively associated with calcification score and the expressions of BMP2 and MGP. While MQSGA score, serum phosphorus and calcium × phosphorus product showed positive relationships with calcification score and the expressions of BMP2 and MGP.
Question: Malnutrition, a new inducer for arterial calcification in hemodialysis patients?
Options:
A. yes
B. no
C. maybe
| Malnutrition is prevalent in hemodialysis patients and is associated with arterial calcification and the expressions of BMP2 and MGP in calcified radial arteries. Malnutrition may be a new inducer candidate for arterial calcification in hemodialysis patients. The answer is: A | A | Malnutrition, a new inducer for arterial calcification in hemodialysis patients? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To define the concentrations of inhibin in serum and tissue of patients with hydatidiform mole and assess their value as a clinical marker of the condition.
- Prospective study of new patients with hydatidiform mole, comparison of paired observations, and case-control analysis.
- A university hospital, two large public hospitals, and a private women's clinic in Japan.
- Seven consecutive referred patients seen over four months with newly diagnosed complete hydatidiform mole, including one in whom the mole was accompanied by viable twin fetuses (case excluded from statistical analysis because of unique clinical features). All patients followed up for six months after evacuation of molar tissue.
- Correlation of serum inhibin concentrations with trophoblastic disease.
- Serum concentrations of inhibin, human chorionic gonadotrophin, and follicle stimulating hormone were compared before and seven to 10 days after evacuation of the mole. Before evacuation the serum inhibin concentrations (median 8.3 U/ml; 95% confidence interval 2.4 to 34.5) were significantly greater than in 21 normal women at the same stage of pregnancy (2.8 U/ml; 2.1 to 3.6), and inhibin in molar tissue was also present in high concentrations (578 U/ml cytosol; 158 to 1162). Seven to 10 days after evacuation inhibin concentrations in serum samples from the same patients declined significantly to values (0.4 U/ml; 0.1 to 1.4) similar to those seen in the follicular phase of normal menstrual cycles. None of the four patients whose serum inhibin concentrations were 0.4 U/ml or less after evacuation developed persistent trophoblastic disease. Though serum human chorionic gonadotrophin concentrations declined after evacuation (6.6 x 10(3) IU/l; 0.8 x 10(3) to 32.6 x 10(3], they remained far higher than in non-pregnant women. Serum follicle stimulating hormone concentrations remained suppressed.
Question: Inhibin: a new circulating marker of hydatidiform mole?
Options:
A. yes
B. no
C. maybe
| In this small study serum inhibin concentrations higher than those found in the early follicular phase one to two weeks after evacuation of a hydatidiform mole seemed to be specific for persistent trophoblastic disease. Further data are needed to confirm these promising results. The answer is: A | A | Inhibin: a new circulating marker of hydatidiform mole? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To examine the clinical effect (efficacy and tolerability) of high doses of zonisamide (ZNS) (>500 mg/d) in adult patients with pharmacoresistant epilepsy.
- Between 2006 and 2013, all epileptic outpatients treated with high doses of ZNS were selected. Safety and efficacy were assessed based on patient and caregiver reports. Serum levels of ZNS and other concomitant antiepileptic drugs were evaluated if available.
- Nine patients (5 female): 8 focal/1 generalized pharmacoresistant epilepsy. Mean age: 34 years. Most frequent seizure type: complex partial seizures; other seizure types: generalized tonic-clonic, tonic, myoclonia. Zonisamide in polytherapy in all (100%), administered in tritherapy in 3 (33%) of 9 patients; mean dose: 633 (600-700) mg/d; efficacy (>50% seizure reduction) was observed in 5 (55%) of 9 patients. Five of 9 patients are still taking high doses of ZNS (more than 1 year). Adverse events were observed in 3 (37%) of 8 patients. Good tolerance to high doses of other antiepileptic drugs had been observed in 6 (66%) of 9 patients. Plasma levels of ZNS were only available in 2 patients; both were in the therapeutic range (34.95, 30.91) (10-40 mg/L).
Question: Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide?
Options:
A. yes
B. no
C. maybe
| High doses of ZNS are effective and safe in pharmacoresistant epileptic patients. Therapeutic drug monitoring of ZNS may be considered at therapeutic failure. The answer is: A | A | Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- A 2008 expert consensus statement outlined the minimum frequency of follow-up of patients with cardiovascular implantable electronic devices (CIEDs).
- We studied 38 055 Medicare beneficiaries who received a new CIED between January 1, 2005, and June 30, 2009. The main outcome measure was variation of follow-up by patient factors and year of device implantation. We determined the number of patients who were eligible for and attended an in-person CIED follow-up visit within 2 to 12 weeks, 0 to 16 weeks, and 1 year after implantation. Among eligible patients, 42.4% had an initial in-person visit within 2 to 12 weeks. This visit was significantly more common among white patients than black patients and patients of other races (43.0% versus 36.8% versus 40.5%; P<0.001). Follow-up within 2 to 12 weeks improved from 40.3% in 2005 to 55.1% in 2009 (P<0.001 for trend). The rate of follow-up within 0 to 16 weeks was 65.1% and improved considerably from 2005 to 2009 (62.3%-79.6%; P<0.001 for trend). Within 1 year, 78.0% of the overall population had at least 1 in-person CIED follow-up visit.
Question: Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice?
Options:
A. yes
B. no
C. maybe
| Although most Medicare beneficiaries who received a new CIED between 2005 and 2009 did not have an initial in-person CIED follow-up visit within 2 to 12 weeks after device implantation, the rate of initial follow-up improved appreciably over time. This CIED follow-up visit was significantly more common in white patients than in patients of other races. The answer is: A | A | Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Minority patients with cancer experience worse control of their pain than do their white counterparts. This disparity may, in part, reflect more miscommunication between minority patients and their physicians. Therefore, we examined whether patient coaching could reduce disparities in pain control in a secondary analysis of a randomized controlled trial.
- Sixty-seven English-speaking adult cancer outpatients, including 15 minorities, with moderate pain over the prior 2 weeks were randomly assigned to the experimental (N = 34) or control group (N = 33). Experimental patients received a 20-minute individualized education and coaching session to increase knowledge of pain self-management, to redress personal misconceptions about pain treatment, and to rehearse an individually scripted patient-physician dialog about pain control. The control group received standardized information on controlling pain. Data on average pain (0-10 scale) were collected at enrollment and 2-week follow-up.
- At enrollment, minority patients had significantly more pain than their white counterparts (6.0 vs 5.0, P = 0.05). At follow-up, minorities in the control group continued to have more pain (6.4 vs 4.7, P = 0.01), whereas in the experimental group, disparities were eliminated (4.0 vs 4.3, P = 0.71). The effect of the intervention on reducing disparities was significant (P = 0.04).
Question: Can patient coaching reduce racial/ethnic disparities in cancer pain control?
Options:
A. yes
B. no
C. maybe
| Patient coaching offers promise as a means of reducing racial/ethnic disparities in pain control. Larger studies are needed to validate these findings and to explore possible mechanisms. The answer is: A | A | Can patient coaching reduce racial/ethnic disparities in cancer pain control? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To investigate whether the Patient Health Questionnaire-9 (PHQ-9) possesses the essential psychometric characteristics to measure depressive symptoms in people with visual impairment.
- The PHQ-9 scale was completed by 103 participants with low vision. These data were then assessed for fit to the Rasch model.
- The participants' mean +/- standard deviation (SD) age was 74.7 +/- 12.2 years. Almost one half of them (n = 46; 44.7%) were considered to have severe vision impairment (presenting visual acuity<6/60 in the better eye). Disordered thresholds were evident initially. Collapsing the two middle categories produced ordered thresholds and fit to the Rasch model (chi = 10.1; degrees of freedom = 9; p = 0.34). The mean (SD) items and persons Fit Residual values were -0.31 (1.12) and -0.25 (0.78), respectively, where optimal fit of data to the Rasch model would have a mean = 0 and SD = 1. Unidimensionality was demonstrated confirming the construct validity of the PHQ-9 and there was no evidence of differential item functioning on a number of factors including visual disability. The person separation reliability value was 0.80 indicating that the PHQ-9 has satisfactory precision. There was a degree of mistargeting as expected in this largely non-clinically depressed sample.
Question: Can clinicians use the PHQ-9 to assess depression in people with vision loss?
Options:
A. yes
B. no
C. maybe
| Our findings demonstrate that the PHQ-9, when scaled with Rasch analysis, forms a linear interval measurement of depressive symptoms suitable for use in a vision impaired population. The answer is: A | A | Can clinicians use the PHQ-9 to assess depression in people with vision loss? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate the efficacy of extracorporeal shock wave lithotripsy (SWL) on lower calyceal calculi in relation to the renal anatomical factors and determine which of these factors can be used to select patients who will benefit from SWL.
- We analyzed retrospectively 78 patients with single radiopaque lower calyceal stones treated with SWL. The patients were evaluated 3 months after lithotripsy with a simple abdominal X-ray and a kidney ultrasound scan. The success of the treatment, removal of all fragments, was correlated with renal anatomical factors measured in the pre-treatment intravenous urography: infundibulopelvic angle, lower infundibulum width, lower infundibulum length, ratio length/width, infundibulum height, and number of minor calyces in the lower calyceal group.
- Three months after SWL treatment, 39 patients were stone-free (NR group) and 39 had residual fragments (R group). Both groups presented no differences in relation to infundibulopelvic angle, width and length of the lower calyceal infundibulum, length/width ratio of the lower infundibulum or number of lower calyces. Height of the infundibulum, described as the distance between the line passing through the lowest part of the calyx containing the calculus and the highest point of the lower lip of renal pelvis, was the only parameter in which significant differences (p = 0.002) were found between the NR and R groups.
Question: Can infundibular height predict the clearance of lower pole calyceal stone after extracorporeal shockwave lithotripsy?
Options:
A. yes
B. no
C. maybe
| Lower Infundibular height could be a good measurement tool for deciding which patients with lower calyceal lithiasis would benefit from SWL treatment. Height of less than 22 mm suggests a good outcome from lithotripsy. The answer is: A | A | Can infundibular height predict the clearance of lower pole calyceal stone after extracorporeal shockwave lithotripsy? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The cytomorphology of liquid-based preparations in urine cytology is different than classic slide preparations.
- To compare the performance of liquid-based preparation specimens to classically prepared urine specimens with a malignant diagnosis in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.
- Participant responses between 2000 and 2007 for urine specimens with a reference diagnosis of high-grade urothelial carcinoma/carcinoma in situ/dysplasia (HGUCA), squamous cell carcinoma, or adenocarcinoma were evaluated. ThinPrep and SurePath challenges were compared with classic preparations (smears, cytospins) for discordant responses.
- There were 18 288 pathologist, 11 957 cytotechnologist, and 8086 "laboratory" responses available. Classic preparations comprised 90% (n = 34 551) of urine challenges; 9% (n = 3295) were ThinPrep and 1% (n = 485) were SurePath. Concordance to the general category of "positive-malignant" was seen in 92% of classic preparations, 96.5% of ThinPrep, and 94.6% of SurePath challenges (P<.001). These results were statistically different for the exact reference interpretation of HGUCA (P<.001) but not for adenocarcinoma (P = .22). Cytotechnologists demonstrate statistically better performance for the general category of "positive-malignant" compared with pathologists for all urinary slide types and for the exact reference interpretation of HGUCA (94% versus 91.1%; P<.001) but not adenocarcinoma (96.3% versus 95.8%; P = .77) or squamous cell carcinoma (93.6% versus 87.7%; P = .07).
Question: Do liquid-based preparations of urinary cytology perform differently than classically prepared cases?
Options:
A. yes
B. no
C. maybe
| Liquid-based preparations performed significantly better in urinary cytology challenges when evaluating malignant categories in the College of American Pathologists interlaboratory comparison program. The liquid-based preparation challenges also performed better for the exact reference interpretation of HGUCA, but no difference was observed for adenocarcinoma challenges. Cytotechnologists perform better than pathologists for all slide types, as well as those demonstrating HGUCA. These results suggest that liquid-based preparations facilitate a more accurate diagnosis than conventional preparations. The answer is: A | A | Do liquid-based preparations of urinary cytology perform differently than classically prepared cases? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To determine whether there are differences between blood pressure (BP) measured by the nurse (NBP), BP measured by the physician (PBP) and self-measured BP in treated hypertensive patients and, if found, to evaluate their clinical importance.
- An observational study is carried out with hypertensive patients recruited from two village-based community health centres in Catalonia (Spain) serving an area with a total population of 2800 inhabitants. All patients treated for hypertension visiting the health centre on a specific day of the week and during the same timetable between October 2000 and May 2001 were included.
- The difference between physician-systolic BP and nurse-systolic BP was 5.16 mmHg (95% CI 2.62-7.7; p<0.001). The difference between physician-systolic BP and self-measured systolic BP was 4.67 mmHg (95% CI 0.89-8.44; p=0.016). The differences between nurse-systolic BP and self-measured systolic BP were not significant (0.49 mmHg; 95% CI 3.71-2.71; p=0.758). With regards to diastolic BP, no significant differences were found between the different ways of measurement. NBP gave the following values: sensitivity (Sn) of 92% and specificity (Sp) of 60%; positive predictive value (PPV) of 65.7% and negative predictive value (NPV) of 90% with a positive coefficient of probability (CP+) of 2.3 and a negative coefficient of probability (CP-) of 0.133. PBP gave the following results: Sn=72%; Sp=66.7%; PPV=64.3%; NPV=74.1%; CP+=2.16 and CP- = 0.420.
Question: Does blood pressure change in treated hypertensive patients depending on whether it is measured by a physician or a nurse?
Options:
A. yes
B. no
C. maybe
| Systolic BP measured by the nurse in treated hypertensive patients is significantly lower than the readings obtained by the physician, and are almost identical to ambulatory BP monitoring. Blood pressure determination by the nurse is desirable not only for diagnosis but also to evaluate the level of control of blood pressure during the follow-up of treated hypertensive patients. The answer is: A | A | Does blood pressure change in treated hypertensive patients depending on whether it is measured by a physician or a nurse? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- From March 2007 to January 2011, 88 DBE procedures were performed on 66 patients. Indications included evaluation anemia/gastrointestinal bleed, small bowel IBD and dilation of strictures. Video-capsule endoscopy (VCE) was used prior to DBE in 43 of the 66 patients prior to DBE evaluation.
- The mean age was 62 years. Thirty-two patients were female, 15 were African-American; 44 antegrade and 44 retrograde DBEs were performed. The mean time per antegrade DBE was 107.4±30.0 minutes with a distance of 318.4±152.9 cm reached past the pylorus. The mean time per lower DBE was 100.7±27.3 minutes with 168.9±109.1 cm meters past the ileocecal valve reached. Endoscopic therapy in the form of electrocautery to ablate bleeding sources was performed in 20 patients (30.3%), biopsy in 17 patients (25.8%) and dilation of Crohn's-related small bowel strictures in 4 (6.1%). 43 VCEs with pathology noted were performed prior to DBE, with findings endoscopically confirmed in 32 cases (74.4%). In 3 cases the DBE showed findings not noted on VCE.
Question: Double balloon enteroscopy: is it efficacious and safe in a community setting?
Options:
A. yes
B. no
C. maybe
| DBE appears to be equally safe and effective when performed in the community setting as compared to a tertiary referral center with a comparable yield, efficacy, and complication rate. The answer is: A | A | Double balloon enteroscopy: is it efficacious and safe in a community setting? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Cancer of the buccal mucosa is an uncommon and aggressive neoplasm of the oral cavity. Less than 2% of patients treated for cancer of the oral cavity at Roswell Park Cancer Institute (RPCI) from 1971 to 1997 had primary buccal cancers. Because the majority of these patients did not undergo any adjuvant treatment, this group provided us with the opportunity to assess the relationship between margin status and local recurrence for both small (T1-T2) and large (T3-T4) tumors treated with surgery alone.
- The RPCI tumor registry database reported 104 patients who were treated for buccal carcinoma. A retrospective chart review identified 27 patients who met our criteria for a buccal mucosal primary tumor (epicenter of the mass in the buccal mucosa). There were 13 men and 14 women, ranging in age from 34 to 94 years (mean, 75). Data were collected regarding patient demographics, presenting symptoms, stage, treatment received, and outcome.
- All patients underwent surgical resection of their primary lesion; 21 (75%) had T1 or T2 tumors. The rate of local recurrence was 56% for the group as a whole. Patients with close or positive margins had a 66% local failure rate as compared with 52% when surgical margins were negative (greater than or equal to 5 mm from the resection margin after tissue fixation; P = ns). Among those in whom negative margins were achieved, patients with T1-T2 disease had a 40% local failure rate with surgical resection alone.
Question: Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control?
Options:
A. yes
B. no
C. maybe
| Local excision of T1 and T2 buccal mucosa cancers with pathologically negative margins had a high rate of local recurrence in our series. Low T-stage and negative margins are not adequate predictors of local control. Even early buccal tumors may benefit from adjuvant therapy to enhance local control. The answer is: B | B | Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To be able to adhere to discharge instructions after a visit to the emergency department (ED), patients should understand both the care that they received and their discharge instructions. The objective of this study is to assess, at discharge, patients' comprehension of their ED care and instructions and their awareness of deficiencies in their comprehension.
- We conducted structured interviews of 140 adult English-speaking patients or their primary caregivers after ED discharge in 2 health systems. Participants rated their subjective understanding of 4 domains: (1) diagnosis and cause; (2) ED care; (3) post-ED care, and (4) return instructions. We assessed patient comprehension as the degree of agreement (concordance) between patients' recall of each of these domains and information obtained from chart review. Two authors scored each case independently and discussed discrepancies before providing a final concordance rating (no concordance, minimal concordance, partial concordance, near concordance, complete concordance).
- Seventy-eight percent of patients demonstrated deficient comprehension (less than complete concordance) in at least 1 domain; 51% of patients, in 2 or more domains. Greater than a third of these deficiencies (34%) involved patients' understanding of post-ED care, whereas only 15% were for diagnosis and cause. The majority of patients with comprehension deficits failed to perceive them. Patients perceived difficulty with comprehension only 20% of the time when they demonstrated deficient comprehension.
Question: Patient comprehension of emergency department care and instructions: are patients aware of when they do not understand?
Options:
A. yes
B. no
C. maybe
| Many patients do not understand their ED care or their discharge instructions. Moreover, most patients appear to be unaware of their lack of understanding and report inappropriate confidence in their comprehension and recall. The answer is: B | B | Patient comprehension of emergency department care and instructions: are patients aware of when they do not understand? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To assess pain-related attentional biases among individuals with episodic migraine.
- Prior studies have examined whether chronic pain patients selectively attend to pain-related stimuli in the environment, but these studies have produced largely mixed findings and focused primarily on patients with chronic musculoskeletal pain. Limited research has implicated attentional biases among chronic headache patients, but no studies have been conducted among episodic migraineurs, who comprise the overwhelming majority of the migraine population.
- This was a case-control, experimental study. Three hundred and eight participants (mean age = 19.2 years [standard deviation = 3.3]; 69.5% female; 36.4% minority), consisting of 84 episodic migraineurs, diagnosed in accordance with International Classification of Headache Disorders (2(nd) edition) criteria using a structured diagnostic interview, and 224 non-migraine controls completed a computerized dot probe task to assess attentional bias toward headache-related pictorial stimuli. The task consisted of 192 trials and utilized 2 emotional-neutral stimulus pairing conditions (headache-neutral and happy-neutral).
- No within-group differences for reaction time latencies to headache vs happy conditions were found among those with episodic migraine or among the non-migraine controls. Migraine status was unrelated to attentional bias indices for both headache (F [1,306] = 0.56, P = .45) and happy facial stimuli (F [1,306] = 0.37, P = .54), indicating a lack of between-group differences. Lack of within- and between-group differences was confirmed with repeated measures analysis of variance.
Question: Do episodic migraineurs selectively attend to headache-related visual stimuli?
Options:
A. yes
B. no
C. maybe
| In light of the large sample size and prior pilot testing of presented images, results suggest that episodic migraineurs do not differentially attend to headache-related facial stimuli. Given modest evidence of attentional biases among chronic headache samples, these findings suggest potential differences in attentional processing between chronic and episodic headache subforms. The answer is: B | B | Do episodic migraineurs selectively attend to headache-related visual stimuli? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Changes in the spectrum of general surgery and the delivery of surgical care have placed the requirement for a mandatory general surgery rotation in the surgical clerkship in question.
- We tested the hypothesis that equal mastery of surgical clerkship objectives can be obtained in a clerkship with and without general surgery. Students chose any two surgical rotations and were assessed by written examination, objective structured clinical examination (OSCE), ward evaluations, self-assessment objectives questionnaire, and satisfaction survey.
- Data for 54 students showed no differences in scores between groups on any parameter. No specific concerns related to the absence of general surgery were identified.
Question: Is a mandatory general surgery rotation necessary in the surgical clerkship?
Options:
A. yes
B. no
C. maybe
| Effective undergraduate surgical education can be offered in many specialty settings. Removal of the requirement for general surgery in clerkship may lead to a more effective use of all educational opportunities. A careful analysis of local programs and facilities is necessary before suggesting this change to other institutions. The answer is: B | B | Is a mandatory general surgery rotation necessary in the surgical clerkship? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- There is increasing concern amongst educators that the provision of recorded lectures may reduce student attendance of live lectures. We therefore sought to determine if the provision of prerecorded lecture video podcasts (VODcasts) to first-year Graduate Entry to Medicine (GEM) students, affected attendance at 21 Physiology lectures within three separate pre-clinical modules.
- Data on lecture attendance, utilization of VODcasts, and whether VODcasts should replace live lectures were drawn from three surveys conducted in academic years 2014-2015 and 2015-2016 on all first-year GEM students in two first-year pre-clinical modules where prerecorded Physiology VODcasts were available for viewing or downloading prior to scheduled live lectures.
- A total of 191/214 (89%) students responded to the three surveys, with 84.3% of students attending all 21 lectures in the study. Only 4% of students missed more than one lecture in each of the three lecture series, with 79% indicating that VODcasts should not replace lectures.
Question: Do prerecorded lecture VODcasts affect lecture attendance of first-yearpre-clinical Graduate Entry to Medicine students?
Options:
A. yes
B. no
C. maybe
| Therefore, we conclude that the attendance of pre-clinical GEM students at live lectures is not significantly impacted upon by the provision of lecture VODcasts, with most students viewing them as useful revision tools rather than as a replacement for live lectures. The answer is: B | B | Do prerecorded lecture VODcasts affect lecture attendance of first-yearpre-clinical Graduate Entry to Medicine students? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of the study was to evaluate, if elderly persons are sufficiently protected against infectious diseases by vaccination.
- 300 elderly (>60 years) and 300 young (<35 years) persons from five Austrian cities were recruited according to the criteria of a field study. Antibody concentrations against tetanus, diphtheria, tickborne encephalitis and influenza were assessed by ELISA or by haemagglutination inhibition test. Disease and vaccination histories were recorded.
- The results of the study demonstrate that protection against infectious diseases was frequently insufficient in the elderly. This was partly due to the fact that old persons were not vaccinated according to recommended strategies. However, low antibody concentration and a short duration of protective humoral immunity were also observed in many elderly persons in spite of regular vaccination. This was not only the case in frail, but also in healthy elderlies.
Question: Vaccine protection in the elderly: are Austrian seniors adequately protected by vaccinations?
Options:
A. yes
B. no
C. maybe
| The data demonstrate that vaccination has a relatively weak and short-lasting effect in old age. The results of the study should stimulate discussions about strategies how vaccinations can be made more effective in old age. Improved campaigns, shortened vaccination intervals as well as the design of novel vaccines tailored to fulfill the specific demands of the aging immune system are imaginable. The answer is: B | B | Vaccine protection in the elderly: are Austrian seniors adequately protected by vaccinations? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The optimal age at which to perform orchiopexy for cryptorchidism has long been debated. The aim of this study was to determine if age at orchiopexy affected testicular atrophy.
- A retrospective review of patients undergoing orchiopexy from 2000 to 2010 was conducted. An individual testis, rather than patient, was used as the dependent variable. A total of 349 testicles from 1126 charts (ICD-9=752.51) were identified. Primary study outcome was testicular survival without atrophy.
- Mean follow up for the study was 25 months. There was postoperative atrophy in 27 testes (7.7%). Intraabdominal testicle was independently associated with increased postsurgical atrophy (p<0.0001). The odds of postsurgical atrophy were 15.66 times higher for an abdominal vs. inguinal location (95% CI: 5.5-44.6). Testicular atrophy was highest for orchiopexy at ages 13-24 months (n=16 of 133, 12%) vs. those less than 13 months (n=3 of 64, 5%), and those greater than 24 months (n=8 of 152, 5%) (p=0.0024). After adjusting for location, age was not statistically significant with postsurgical atrophy (p=0.055).
Question: Undescended testes: does age at orchiopexy affect survival of the testis?
Options:
A. yes
B. no
C. maybe
| From this study we conclude that there is no increase in testicular atrophy in patients less than 13 months. The answer is: B | B | Undescended testes: does age at orchiopexy affect survival of the testis? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- We aimed to investigate the glomerular hyperfiltration due to pregnancy in women with more parities.
- Five hundred women aged 52.57 +/- 8.08 years, without a history of hypertension, diabetes mellitus or complicated pregnancy were involved in the study. They were divided into three groups. Group 1: women with no or one parity (n = 76); group 2: women with two or three parities (n = 333); group 3: women with four or more parities (n = 91). Laboratory parameters and demographical data were compared between the three groups.
- Mean age, serum urea and serum creatinine were similar between three groups. Patients in group 3 had significantly higher GFR values compared to groups 1 and 2 (109.44 +/- 30.99, 110.76 +/- 30.22 and 121.92 +/- 34.73 mL/min/1.73 m(2) for groups 1, 2 and 3, respectively; P = 0.008 for group 1 vs group 3; P = 0.002 for group 2 vs group 3).
Question: Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities?
Options:
A. yes
B. no
C. maybe
| In our study, we suggest that glomerular hyperfiltration due to pregnancy does not have adverse effects on kidney in women with more parities. Pregnancy may have possible protective mechanisms for kidney against adverse effects of glomerular hyperfiltration. The answer is: B | B | Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to investigate the influence of the pharmacokinetics of s.c. anti-TNF agents on the grade of US-detected synovitis in RA patients.
- Fifty RA patients were prospectively recruited from the Biologic Therapy Unit of our hospital. Inclusion criteria were being in treatment with s.c. anti-TNF agents and having had neither changes in therapy nor local corticosteroid injections in the previous 3 months. Patients underwent clinical, laboratory [28-joint DAS (DAS28) and Simplified Disease Activity Index (SDAI)]and US assessment at two time points, i.e. at peak plasma drug concentration and at trough plasma drug concentration. US assessments were performed blindly to the anti-TNF agent, the administration time and the clinical and laboratory data. Twenty-eight joints were investigated for the presence and grade (0-3) of B-mode synovitis and synovial power Doppler signal. Global indices for B-mode synovitis (BSI) and Doppler synovitis (DSI) were calculated for 12 joints and for wrist-hand-ankle-foot joints. B-mode US remission was defined as a BSI<1 and Doppler US remission as a DSI<1.
- There were no significant differences between the clinical, laboratory and B-mode and Doppler US parameters at peak time and trough time (P = 0.132-0.986). There were no significant differences between the proportion of patients with active disease and those in remission according to DAS28, SDAI, B-mode US and Doppler US at peak time and trough time assessments (P = 0.070-1).
Question: Does ultrasound-scored synovitis depend on the pharmacokinetics of subcutaneous anti-TNF agents in patients with rheumatoid arthritis?
Options:
A. yes
B. no
C. maybe
| Our results suggested that s.c. anti-TNF pharmacokinetics do not significantly influence US-scored synovitis in RA patients. The answer is: B | B | Does ultrasound-scored synovitis depend on the pharmacokinetics of subcutaneous anti-TNF agents in patients with rheumatoid arthritis? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The CLASS Act, which was part of the Affordable Care Act of 2010, established a voluntary personal assistance services (PAS) insurance program. However, concerns about enrollment and adverse selection led to repeal of the CLASS Act in 2013.
- To estimate the number of middle-aged adults interested in purchasing PAS insurance, the sociodemographic, socioeconomic and disability attributes of this population, and the maximum monthly premium they would be willing to pay for such coverage.
- A total of 13,384 adults aged 40-65 answered questions about their interest in PAS insurance in the 2011 Sample Adult National Health Interview Survey. We applied survey weights for the U.S. population and conducted logistic regression analyses to identify personal factors associated with interest in paying for the CLASS program.
- An estimated 25.8 million adults aged 40-65 (26.7%) said they would be interested in paying for a public insurance program to cover PAS benefits. However, interest in PAS insurance varied by age, race, ethnicity, region, income, disability status, and family experience with ADL assistance. Only 1.6 million adults aged 40-65 (1.8%) said they would be willing to pay $100 per month or more for coverage.
Question: After CLASS--Is a voluntary public insurance program a realistic way to meet the long-term support and service needs of adults with disabilities?
Options:
A. yes
B. no
C. maybe
| While more than a quarter of the middle-aged adult population said they were interested in PAS insurance, actual participation would be highly dependent on premium rates. The current lack of publicly subsidized insurance for long-term care and personal assistance services remains a serious gap in the disability service system. The answer is: B | B | After CLASS--Is a voluntary public insurance program a realistic way to meet the long-term support and service needs of adults with disabilities? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Medical records of 121 people who received inpatient rehabilitation were retrospectively screened; records of 50 people discharged home and at high falls risk (fall in last 12 months, fall preceding/during admission) were audited. Data extracted included falls risk identification during rehabilitation and in discharge documentation; falls risk factors assessed; and fall prevention strategies implemented.
- Discharge documentation correctly identified falls risk for just nine of the 50 people. Patients at high falls risk had a median of 8.0 (interquartile range 6-10) of 17 risk factors. There was limited evidence of assessment for osteoporosis (n = 8), footwear (n = 4) and visual assessment in the previous 2 years (n = 1). Patients received a median of 6.5 (interquartile range 5-9) out of 16 possible strategies. Common strategies were mobility (n = 48), strength (n = 44) and Personal Activity of Daily Living training (n = 43). For 12 risk factors, if the factor was present, there was evidence of a strategy in more than 80% of records.
Question: Preparing patients at high risk of falls for discharge home after rehabilitation: Do we meet the guidelines?
Options:
A. yes
B. no
C. maybe
| There was little evidence that people at high risk of falls received systematic falls risk assessment during rehabilitation. When a risk was identified, generally a strategy was implemented. However, failure to assess some risk factors might have limited fall prevention strategies offered. Failure to adequately address risks during hospitalization could contribute to falls post-discharge. Geriatr Gerontol Int 2016; 16: 570-576. The answer is: B | B | Preparing patients at high risk of falls for discharge home after rehabilitation: Do we meet the guidelines? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- We evaluated the differences between percutaneous ethanol injection with and without aspiration of ethanol-mixed fluid for treatment of benign cystic thyroid nodules.
- We examined 60 patients with benign cystic thyroid nodules confirmed by fine-needle aspiration biopsy and divided them into 2 groups according to nonaspiration (group A, n = 30) or aspiration (group B, n = 30) of ethanol-mixed fluid after intracystic ethanol injection. We evaluated in both groups the complete disappearance of the cystic portion of the thyroid nodule on follow-up ultrasonography (first follow-up ultrasonography; mean, 4.6 months in group A; mean, 4.4 months in group B) (chi-square test), side effects or complications during and after the procedure (chi-square test), and the total procedure time (Student t test).
- Most patients showed complete disappearance of the cystic portion of the thyroid nodule (group A, n = 29; group B, n = 28), and they revealed no recurrence on follow-up ultrasonography. There was no statistical difference in the success rates between group A and group B (P>.05). Pain, the most common side effect, and other mild side effects or complications occurred in small numbers of patients in each group, but there was no significant difference in side effects or complications between the 2 groups (P>.05), except for intracystic hemorrhage (P<.05) and the complaint of all group B patients due to a double puncture (P<.001). The total procedure time was nearly double in group B than in group A because of the additional procedures, such as complete evacuation of the ethanol-mixed fluid and the 10-minute compression.
Question: Percutaneous ethanol injection for benign cystic thyroid nodules: is aspiration of ethanol-mixed fluid advantageous?
Options:
A. yes
B. no
C. maybe
| Percutaneous ethanol injection without aspiration of ethanol-mixed fluid seems to be the preferable method of treatment of benign cystic thyroid nodules from the perspective of both the physician and the patient. The answer is: B | B | Percutaneous ethanol injection for benign cystic thyroid nodules: is aspiration of ethanol-mixed fluid advantageous? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Juvenile and adult forms of ankylosing spondylitis (AS) have been shown to have different clinical presentation and outcome in Caucasians. We did this retrospective analysis to see if similar differences exist in the Indian population.
- Case records of 210 Indian patients diagnosed with AS according to modified New York criteria were reviewed. Data were collected regarding age of onset, clinical features, drug treatment, and outcome at last follow-up. Patients with onset before 17 years of age were classified as having juvenile AS (JAS) and the rest with adult AS (AAS).
- There were 150 patients with AAS and 60 with JAS. The latter had higher male preponderance, more frequent onset with peripheral arthritis, and greater involvement of hip and knee joints. Valvular dysfunction was seen only in patients with JAS.
Question: Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis?
Options:
A. yes
B. no
C. maybe
| In this group of subjects, juvenile AS had onset more often with oligoarthritis and enthesitis than with spinal disease. Hip and knee joint involvement was more common in JAS than AAS. The answer is: B | B | Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The number of new diagnoses of HIV infection is rising in the northwestern hemisphere and it is becoming increasingly important to understand the mechanisms behind this trend.
- To evaluate whether reported unsafe sexual behaviour among HIV- infected individuals is changing over time.
- Participants in the Swiss HIV Cohort Study were asked about their sexual practices every 6 months for 3 years during regular follow-up of the cohort beginning on 1 April 2000.
- : Logistic regression models were fit using generalized estimating equations assuming a constant correlation between responses from the same individual.
- At least one sexual behaviour questionnaire was obtained for 6545 HIV-infected individuals and the median number of questionnaires completed per individual was five. There was no evidence of an increase in reported unsafe sex over time in this population [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.96-1.05]. Females (OR, 1.38; 95% CI, 1.19-1.60), 15-30 year olds (OR, 1.26; 95% CI, 1.09-1.47), those with HIV-positive partners (OR, 12.58; 95% CI, 10.84-14.07) and those with occasional partners (OR, 3.25; 95% CI, 2.87-3.67) were more likely to report unsafe sex. There was no evidence of a response bias over time, but individuals were less willing to leave questions about their sexual behaviour unanswered or ambiguous (OR, 0.93; 95% CI, 0.90-0.97).
Question: Is unsafe sexual behaviour increasing among HIV-infected individuals?
Options:
A. yes
B. no
C. maybe
| There was no evidence of a trend in unsafe sex behaviour over time. However, several subgroups were identified as being more likely to report unsafe sex and should be targeted for specific interventions. The answer is: B | B | Is unsafe sexual behaviour increasing among HIV-infected individuals? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Infants referred to our institution with a final diagnosis of ARM were retrospectively reviewed between 2001 and 2009. The first cohort consisted of patients that were referred between November 2001 and November 2006 with the diagnosis of an ARM that had been delayed for more than 48 h. The second cohort was those referred between December 2006 and May 2009 with whom the diagnosis of ARM had not been made within 24 h of birth.
- Nineteen infants were referred with delayed diagnosis of an ARM over the 7.5 years of the study. Of 44 patients referred to our institution between December 2006 and May 2009, diagnosis of an ARM was delayed more than 24 h in 14 (32%). There was no difference in gender, birth weight, prematurity, type of malformation or presence of associated anomalies between those with timely and delayed diagnosis of their ARM. A significantly greater proportion of those with a delayed diagnosis presented with obstructive symptoms (86% vs. 27%, P<0.001), including abdominal distension (57%) and delayed passage of meconium or stool (29%). Despite undergoing neonatal examination, the diagnosis of ARM was missed in 12 patients overall.
Question: Delayed diagnosis of anorectal malformations: are current guidelines sufficient?
Options:
A. yes
B. no
C. maybe
| Delayed diagnosis of an ARM appears to be common, occurring in approximately 32% of patients referred to our institution over the last 2.5 years. Current guidelines appear insufficient to ensure prompt diagnosis of ARM. The answer is: B | B | Delayed diagnosis of anorectal malformations: are current guidelines sufficient? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The main treatment for rectal carcinoma is surgery. Preoperative chemoradiation (CRT) is advocated to reduce local recurrence and improve resection of mid and low tethered rectal tumors.
- Fifty-two patients with mid or low rectal tumors underwent CRT (external beam radiation plus 5-fluorouracil plus folinic acid). Patients who had low rectal tumors with complete response (CR) were not submitted to surgical treatment. All other patients were submitted to surgery, independently of the response. Mean follow-up was 32.1 months.
- Five-year overall survival was 60.5%. Clinical evaluation after CRT showed CR in 10 cases (19.2%), all low tumors; incomplete response (>50%) in 21 (40.4%); and no response (<50%) in 19 (36.6%). Among the 10 cases with CR, 8 presented with local recurrence within 3.7 to 8.8 months. Two patients were not submitted to surgery and are still alive without cancer after 37 and 58 months. Thirty-nine patients had radical surgery. Seven had local recurrences after CRT plus surgery (17.9%). Overall survival was negatively affected by lymph node metastases (P =.017) and perineural invasion (P =.026).
Question: Chemoradiation instead of surgery to treat mid and low rectal tumors: is it safe?
Options:
A. yes
B. no
C. maybe
| Exclusive CRT approach is not safe to treat patients with low infiltrative rectal carcinoma. The answer is: B | B | Chemoradiation instead of surgery to treat mid and low rectal tumors: is it safe? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The potential effects of binge drinking during pregnancy on child motor function have only been assessed in a few, small studies. We aimed to examine the effects of binge alcohol consumption during early pregnancy, including number of binge episodes and timing of binge drinking, on child motor function at age 5.
- We performed a prospective follow-up study of 678 women and their children sampled from the Danish National Birth Cohort based on maternal alcohol consumption during pregnancy. At 5 years of age, the children were tested with the Movement Assessment Battery for Children. Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, sex of child, and tester were considered core confounders, while the full model also controlled for prenatal maternal average alcohol intake, maternal age and prepregnancy body mass index, parity, home environment, postnatal parental smoking, health status, participation in organized sport, and indicators for hearing and vision impairment.
- There were no systematic or significant differences in motor function between children of mothers reporting isolated episodes of binge drinking and children of mothers with no binge episodes. No association was observed with respect to the number of binge episodes (maximum of 12) and timing of binge drinking.
Question: Does binge drinking during early pregnancy increase the risk of psychomotor deficits?
Options:
A. yes
B. no
C. maybe
| In this study, we found no systematic association between isolated episodes of binge drinking during early pregnancy and child motor function at age 5. The answer is: B | B | Does binge drinking during early pregnancy increase the risk of psychomotor deficits? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The authors determine whether prevention influences the use of health services. Fluoridation's effect on restorative dental demand among 972 Washington state employees and spouses, aged 20 to 34 years, in two fluoridated communities and a nonfluoridated community was examined.
- At baseline, adults were interviewed by telephone, and oral assessments were conducted to measure personal characteristics, lifetime exposure to fluoridated water, oral disease, and the quality of restorations. Adults were followed for 2 years to measure dental demand from dental claims. Each adult's baseline and claims data were linked with provider and practice variables collected from the dentist who provided treatment.
- Relative to adults with no lifetime exposure to fluoridated water, adults drinking fluoridated water for half or more of their lives had less disease at baseline and a lower but nonsignificant probability of receiving a restoration in the follow-up period. In the 2-year follow-up period, however, more than half of the restorations were performed to replace fillings of satisfactory or ideal quality at baseline. When only teeth with decay and unsatisfactory fillings at baseline were considered, adults with high fluoridation exposure had a lower probability of receiving a restoration than adults with no exposure. Market effects also were detected in demand equations; relative to adults in the nonfluoridated community, adults residing in the fluoridated community with a large dentist supply received a greater number of restorations, suggesting potential supplier-induced demand from less disease and fewer patients.
Question: Does fluoridation reduce the use of dental services among adults?
Options:
A. yes
B. no
C. maybe
| Among adults aged 20 to 34 years with private dental insurance, fluoridation reduces oral disease but may or may not reduce use of restorative services, depending on dentists' clinical decisions. The answer is: C | C | Does fluoridation reduce the use of dental services among adults? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- As part of an MRC funded study into primary care oral anticoagulation management, INR measurements obtained in general practice were validated against values on the same samples obtained in hospital laboratories. A prospective comparative trial was undertaken between three hospital laboratories and nine general practices. All patients attending general practice based anticoagulant clinics had parallel INR estimations performed in general practice and in a hospital laboratory.
- 405 tests were performed. Comparison between results obtained in the practices and those in the reference hospital laboratory (gold standard), which used the same method of testing for INR, showed a correlation coefficient of 0.96. Correlation coefficients comparing the results with the various standard laboratory techniques ranged from 0.86 to 0.92. It was estimated that up to 53% of tests would have resulted in clinically significant differences (change in warfarin dose) depending upon the site and method of testing. The practice derived results showed a positive bias ranging from 0.28 to 1.55, depending upon the site and method of testing.
Question: Is the international normalised ratio (INR) reliable?
Options:
A. yes
B. no
C. maybe
| No technical problems associated with INR testing within primary care were uncovered. Discrepant INR results are as problematic in hospital settings as they are in primary care. These data highlight the failings of the INR to standardise when different techniques and reagents are used, an issue which needs to be resolved. For primary care to become more involved in therapeutic oral anticoagulation monitoring, close links are needed between hospital laboratories and practices, particularly with regard to training and quality assurance. The answer is: C | C | Is the international normalised ratio (INR) reliable? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The diagnosis of acute appendicitis is still difficult and the results are unsatisfactory in three particular patient groups: in children, in fertile-age women and in elderly patients. As our population ages, the challenge for expedient diagnosis and intervention in older age groups will become more and more significant. The present study aimed at clarifying the role of leukocyte count and C-reactive protein (CRP) measurements in the diagnosis of acute appendicitis in the elderly. In particular, are there patients with acute appendicitis but unelevated leukocyte count and CRP?
- Eighty-three consecutive elderly patients underwent appendectomy for suspected acute appendicitis. The mean leukocyte count and CRP value were calculated in patients with an uninflamed appendix (group A) and in those with acute appendicitis (group B). The percentages of patients with: (1) both values unelevated; (2) only leukocyte count elevated; (3) only CRP value elevated; (4) both values elevated were calculated within the groups A and B.
- There was no statistically significant difference in leukocyte counts or CRP values between patients with an uninflamed appendix (group A) and those with acute appendicitis (group B). When the patients were divided into the four subgroups, the most conspicuous finding was that group B (acute appendicitis, n = 73) contained no patients with both values unelevated.
Question: Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly?
Options:
A. yes
B. no
C. maybe
| Although elevated leukocyte count and CRP value cannot effectively establish the diagnosis of acute appendicitis in the elderly, unelevated values exclude it. Accordingly, appendectomy is not recommended to be performed in an elderly patient with unelevated leukocyte count and CRP value, although clinical symptoms and signs indicate acute appendicitis. The answer is: C | C | Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Up to 30 % of patients who have undergone laparoscopic sleeve gastrectomy require revision surgery for inadequate weight loss, weight regain, and/or the development of severe upper gastrointestinal symptoms. The aim of this retrospective study was to evaluate the safety and efficacy of laparoscopic fundectomy (LF) in cases of a residual fundus/neofundus development regarding GERD symptoms.
- The study group comprised 19 patients (17 female; mean BMI 35.4 kg/m(2)) divided into 2 groups. Group A (n = 10) patients with severe GERD and evidence of residual fundus/neofundus, Hiatal hernia with good results in terms of weight loss. Group B (n = 9) patients with severe GERD, a residual fundus/neofundus, inadequate weight loss or weight regain. Fundectomy was indicated when a residual fundus/neofundus was associated with severe GERD symptoms. The presence of a residual fundus/neofundus was assessed by a barium swallow and/or multislice computed tomography.
- No mortality or intra-operative complications occurred. Five postoperative complications occurred: 2 cases of bleeding, 1 mid-gastric stenosis and 2 leaks (10.5 %). All patients experienced improvements in their GERD symptoms and stopped PPI treatment. Group B exhibited an additional %EWL of 53.4 % at 24 months.
Question: Residual fundus or neofundus after laparoscopic sleeve gastrectomy: is fundectomy safe and effective as revision surgery?
Options:
A. yes
B. no
C. maybe
| LF and cruroplasty is feasible and has good results in terms of GERD symptoms control and additional weight loss. The high rate of postoperative complications observed in this series remains a matter of concern. A re-sleeve procedure might be considered as an alternative to RYGB/DS conversion restricted to selected patients. The answer is: C | C | Residual fundus or neofundus after laparoscopic sleeve gastrectomy: is fundectomy safe and effective as revision surgery? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The recent literature shows an increased incidence of obstructive sleep apnea (OSA) in patients with idiopathic pulmonary fibrosis (IPF). On the other hand, there are no published studies related to continuous positive airway pressure (CPAP) treatment in this patient group. Our aim was to assess the effect of CPAP on sleep and overall life quality parameters in IPF patients with OSA and to recognize and overcome possible difficulties in CPAP initiation and acceptance by these patients.
- Twelve patients (ten males and two females, age 67.1 ± 7.2 years) with newly diagnosed IPF and moderate to severe OSA, confirmed by overnight attended polysomnography, were included. Therapy with CPAP was initiated after a formal in-lab CPAP titration study. The patients completed the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), the Functional Outcomes in Sleep Questionnaire (FOSQ), the Fatigue Severity Scale (FSS), the SF-36 quality of life questionnaire, and the Beck Depression Inventory (BDI) at CPAP initiation and after 1, 3, and 6 months of effective CPAP therapy.
- A statistically significant improvement was observed in the FOSQ at 1, 3, and 6 months after CPAP initiation (baseline 12.9 ± 2.9 vs. 14.7 ± 2.6 vs. 15.8 ± 2.1 vs. 16.9 ± 1.9, respectively, p = 0.02). Improvement, although not statistically significant, was noted in ESS score (9.2 ± 5.6 vs. 7.6 ± 4.9 vs. 7.5 ± 5.3 vs. 7.7 ± 5.2, p = 0.84), PSQI (10.7 ± 4.4 vs. 10.1 ± 4.3 vs. 9.4 ± 4.7 vs. 8.6 ± 5.2, p = 0.66), FSS (39.5 ± 10.2 vs. 34.8 ± 8.5 vs. 33.6 ± 10.7 vs. 33.4 ± 10.9, p = 0.44), SF-36 (63.2 ± 13.9 vs. 68.9 ± 13.5 vs. 72.1 ± 12.9 vs. 74.4 ± 11.3, p = 0.27), and BDI (12.9 ± 5.5 vs. 10.7 ± 4.3 vs. 9.4 ± 4.8 vs. 9.6 ± 4.5, p = 0.40). Two patients had difficulty complying with CPAP for a variety of reasons (nocturnal cough, claustrophobia, insomnia) and stopped CPAP use after the first month, despite intense follow-up by the CPAP clinic staff. Heated humidification was added for all patients in order to improve the common complaint of disabling nocturnal cough.
Question: CPAP therapy in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea: does it offer a better quality of life and sleep?
Options:
A. yes
B. no
C. maybe
| Effective CPAP treatment in IPF patients with OSA results in a significant improvement in daily living activities based on the FOSQ, namely an OSA-specific follow-up instrument. Improvement was also noted in other questionnaires assessing quality of life, though not to a statistically significant degree, probably because of the multifactorial influences of IPF on physical and mental health. The probability of poor CPAP compliance was high and could only be eliminated with intense follow-up by the CPAP clinic staff. The answer is: C | C | CPAP therapy in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea: does it offer a better quality of life and sleep? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The present study asked whether the processing of affective prosody is modulated by spatial attention. Pseudo-words with a neutral, happy, threatening, and fearful prosody were presented at two spatial positions. Participants attended to one position in order to detect infrequent targets. Emotional prosody was task irrelevant. The electro-encephalogram (EEG) was recorded to assess processing differences as a function of spatial attention and emotional valence.
- Event-related potentials (ERPs) differed as a function of emotional prosody both when attended and when unattended. While emotional prosody effects interacted with effects of spatial attention at early processing levels (<200 ms), these effects were additive at later processing stages (>200 ms).
Question: Is the processing of affective prosody influenced by spatial attention?
Options:
A. yes
B. no
C. maybe
| Emotional prosody, therefore, seems to be partially processed outside the focus of spatial attention. Whereas at early sensory processing stages spatial attention modulates the degree of emotional voice processing as a function of emotional valence, emotional prosody is processed outside of the focus of spatial attention at later processing stages. The answer is: C | C | Is the processing of affective prosody influenced by spatial attention? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Embalming is the through disinfection and art of preserving bodies after death using chemical substances. It keeps a body life like in appearance during the time it lies in a state prior to funeral.
- This study was undertaken to investigate the effectiveness of Raksi in sacrificed rats in arresting postmortem changes and establishing scientific fact whether Raksi can be an alternative to standard embalming constituent if it is not available.
- 50 albino rats were systematically randomized into control and experiment groups. Raksi and distilled water were injected for embalming purpose intraventricularly in experiment and control groups of rats respectively and kept for 48 to 96 hours for observation for postmortem changes.
- Observations made at 48 and 72 hours of embalming revealed that Raksi can arrest postmortem changes in the rats up to 72 hours (3rd day) successfully in the experimental group whereas moderate to severe postmortem changes were seen in the control group. The experimental group showed mild degree of putrefactive changes, liberation of gases and liquefaction of tissues only at 96 hours (4th day) of embalming.
- The Raksi used in this experiment contained 34% of alcohol, which was determined by an alcohol hydrometer. Experiment clearly demonstrated from its result that raksi can be utilised temporarily for embalming since it contains alcohol and has preservative, bactericidal and disinfectant properties.
Question: Can homemade alcohol (Raksi) be useful for preserving dead bodies?
Options:
A. yes
B. no
C. maybe
| It is concluded from the study that this knowledge if applied to dead human subjects, may preserve dead bodies temporarily allowing delayed funeral. The answer is: A | A | Can homemade alcohol (Raksi) be useful for preserving dead bodies? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Voluntary asphyxiation among children, preteens, and adolescents by hanging or other means of inducing hypoxia/anoxia to enhance sexual excitement is not uncommon and can lead to unintended death. This study addresses autoerotic asphyxiation (AEA) with the intent of increasing pediatricians' knowledge of the syndrome and awareness of its typical onset among young patients. AEA is characteristically a clandestine and elusive practice. Provided with relevant information, pediatricians can identify the syndrome, demonstrate a willingness to discuss concerns about it, ameliorate distress, and possibly prevent a tragedy.
- A retrospective study was undertaken of published cases both fatal and nonfatal and included personal communications, referenced citations, clinical experience, and theoretical formulations as to causation. Characteristic AEA manifestations, prevalence, age range, methods of inducing hypoxia/anoxia, and gender weighting are presented. All sources were used as a basis for additional considerations of etiology and possibilities for intervention.
- AEA can be conceptualized as a personalized, ritualized, and symbolic biopsychosocial drama. It seems to be a reenactment of intense emotional feeling-states involving an identification and sadomasochistic relationship with a female figure. Inept AEA practitioners can miscalculate the peril of the situation that they have contrived and for numerous reasons lose their gamble with death.
Question: Autoerotic asphyxiation: secret pleasure--lethal outcome?
Options:
A. yes
B. no
C. maybe
| Pediatricians should be alert to the earliest manifestations of AEA. Awareness of choking games among the young and, of those, a subset who eventually progress to potentially fatal AEA is strongly encouraged among all primary care professionals who may be able to interrupt the behavior. The answer is: A | A | Autoerotic asphyxiation: secret pleasure--lethal outcome? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Broad-based electronic health information exchange (HIE), in which patients' clinical data follow them between care delivery settings, is expected to produce large quality gains and cost savings. Although these benefits are assumed to result from reducing redundant care, there is limited supporting empirical evidence.
- To evaluate whether HIE adoption is associated with decreases in repeat imaging in emergency departments (EDs).DATA SOURCE/
- ED discharge data from the State Emergency Department Databases for California and Florida for 2007-2010 were merged with Health Information Management Systems Society data that report hospital HIE participation.
- Using regression with ED fixed effects and trends, we performed a retrospective analysis of the impact of HIE participation on repeat imaging, comparing 37 EDs that initiated HIE participation during the study period to 410 EDs that did not participate in HIE during the same period. Within 3 common types of imaging tests [computed tomography (CT), ultrasound, and chest x-ray), we defined a repeat image for a given patient as the same study in the same body region performed within 30 days at unaffiliated EDs.
- In our sample there were 20,139 repeat CTs (representing 14.7% of those cases with CT in the index visit), 13,060 repeat ultrasounds (20.7% of ultrasound cases), and 29,703 repeat chest x-rays (19.5% of x-ray cases). HIE was associated with reduced probability of repeat ED imaging in all 3 modalities: -8.7 percentage points for CT [95% confidence interval (CI): -14.7, -2.7], -9.1 percentage points for ultrasound (95% CI: -17.2, -1.1), and -13.0 percentage points for chest x-ray (95% CI: -18.3, -7.7), reflecting reductions of 44%-67% relative to sample means.
Question: Does health information exchange reduce redundant imaging?
Options:
A. yes
B. no
C. maybe
| HIE was associated with reduced repeat imaging in EDs. This study is among the first to find empirical support for this anticipated benefit of HIE. The answer is: A | A | Does health information exchange reduce redundant imaging? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to determine whether postictal psychotic episodes (PIPE) are predictive of the development of interictal psychotic episodes (IPE).
- This was a retrospective study of 18 consecutive adults with a partial seizure disorder and PIPE (study group) and 36 patients with a partial seizure disorder but without PIPE (control group). These two groups were compared with respect to the likelihood of developing IPE over an 8-year follow-up period and the variables operant in the development of IPE. Statistical analyses consisted of logistic regression models to identify the variables predictive of the development of IPE. Predictors included: number and location of ictal foci, seizure type, etiology, age at seizure onset, duration of seizure disorder, MRI abnormalities, and psychiatric history prior to the index video/EEG monitoring (other than PIPE).
- Seven patients with PIPE and one control patient went on to develop an IPE. Predictors of IPE in univariate logistic regression analyses included a history of PIPE (P=0.006), male gender (P=0.028), and having bilateral ictal foci (P=0.048). Significance disappeared for all of these variables when they were entered into a multivariate analysis.
Question: Long-term significance of postictal psychotic episodes II. Are they predictive of interictal psychotic episodes?
Options:
A. yes
B. no
C. maybe
| A history of PIPE may be a risk factor for the development of IPE. Yet, the disappearance of significance on multivariate analysis indicates that it is not an independent predictor. The answer is: A | A | Long-term significance of postictal psychotic episodes II. Are they predictive of interictal psychotic episodes? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The effect of topical N-acetylcysteine (NAC) application was investigated on the healing of acute experimental tympanic membrane perforations.
- Twenty guinea pigs were used in this study. Under intraperitoneal ketamine anesthesia, incisional myringotomies were performed in the posterosuperior quadrant of the tympanic membranes with a straight otologic hook. The diameter of the perforations was approximately 2 mm. Perforations in both ears were treated with freshly prepared sponges soaked in either 0.1 ml 0.9% NaCl solution (10 control animals) or 0.6 mg/0.1 ml NAC (10 animals) for three consecutive days. All the tympanic membranes were examined by otomicroscopy on the third, fifth, seventh, and ninth days.
- In the control group, all the perforations were completely closed at the end of nine days. During the same period, only 40% of the perforations were completely closed in the NAC group. The remaining ears exhibited otorrhea by the third day.
Question: Does topical N-acetylcysteine application after myringotomy cause severe otorrhea?
Options:
A. yes
B. no
C. maybe
| N-acetylcysteine may cause severe otorrhea in the healing process of tympanic membrane perforations. Further studies including histopathological examinations are required to elucidate this condition. The answer is: A | A | Does topical N-acetylcysteine application after myringotomy cause severe otorrhea? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Selection into general practice training is undertaken using a competency based approach. The clear advantage of this approach over traditional methods has been demonstrated through evaluation of its validity and reliability. However, the relationship between selection and performance in the Royal College of General Practitioner examinations (MRCGP) has yet to be explored. The MRCGP comprises of an applied knowledge test (AKT), a clinical skills assessment (CSA) and workplace-based assessments (WPBA).AIM: To explore the predictive validity of general practice selection scores using the AKT and CSA elements of the MRCGP as a final outcome measure.
- This study carried out a retrospective analysis of 101 trainees from the Wales Deanery who were successfully selected on to general practice training in 2007. Selection data consisted of an overall selection score as well as scores from each individual stage of selection. Correlation was used to explore associations between selection scores and examination scores.
- The score for overall performance at selection achieved statistically significant correlation with examination performance (r = 0.491 for the AKT and r = 0.526 for the CSA, P<0.01).
Question: Do general practice selection scores predict success at MRCGP?
Options:
A. yes
B. no
C. maybe
| The general practice selection process is predictive of future performance in the MRCGP. The answer is: A | A | Do general practice selection scores predict success at MRCGP? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Twenty-eight female Sprague Dawley rats were allocated randomly to 4 groups. The sham group (group 1) was only subjected to catheter insertion, not to pneumoperitoneum. Group 2 received a 1 mg/kg dose of 0.9% sodium chloride by the intraperitoneal route for 10 min before pneumoperitoneum. Groups 3 and 4 received 6 and 12 mg/kg edaravone, respectively, by the intraperitoneal route for 10 min before pneumoperitoneum. After 60 min of pneumoperitoneum, the gas was deflated. Immediately after the reperfusion period, both ovaries were excised for histological scoring, caspase-3 immunohistochemistry and biochemical evaluation including glutathione (GSH) and malondialdehyde (MDA) levels. Also, total antioxidant capacity (TAC) was measured in plasma samples to evaluate the antioxidant effect of edaravone.
- Ovarian sections in the saline group revealed higher scores for follicular degeneration and edema (p<0.0001) when compared with the sham group. Administration of different doses of edaravone in rats significantly prevented degenerative changes in the ovary (p<0.0001). Caspase-3 expression was only detected in the ovarian surface epithelium in all groups, and there was a significant difference between the treatment groups and the saline group (p<0.0001). Treatment of rats with edaravone reduced caspase-3 expression in a dose-dependent manner. Moreover, biochemical measurements of oxidative stress markers (MDA, GSH and TAC) revealed that prophylactic edaravone treatment attenuated oxidative stress induced by I/R injury.
Question: Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection?
Options:
A. yes
B. no
C. maybe
| These results indicate that prophylactic treatment with edaravone prevents I/R-induced ovarian damage during pneumoperitoneum in an experimental rat model. The answer is: A | A | Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- A cross sectional study of 38 patients fulfilling the classification criteria for SLE. The patients visited a rheumatology outpatient clinic in Switzerland between January 2002 and December 2004. The last assessment during this period was used for the study. The assessment included, besides demographic data, the measurement of disease activity using the BILAG index, the measurement of disease damage using the SLICC/ACR damage index (SDI), as well as the patient's self assessed health status using the patient's questionnaire Medical Outcome Survey Short Form 36 (SF-36).
- A total of 36 women and 2 men were included in the study (median age: 43 yrs, median disease duration: 11 yrs). Increased disease activity (total BILAG) was shown to be significantly correlated with reduced physical function. A greater damage (total SDI) correlated significantly with reduced role function due to emotional limitations. Neither age nor disease duration showed any significant correlation with health status in this study.
Question: Are there associations of health status, disease activity and damage in SLE patients?
Options:
A. yes
B. no
C. maybe
| The present study, which is based on internationally accepted assessment tools for SLE patients, shows a significant relationship between increased disease activity and reduced physical function. This result emphasizes the importance of optimizing treatment aiming at reducing disease activity. The answer is: A | A | Are there associations of health status, disease activity and damage in SLE patients? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The apparent favorable effect of alcohol on the risk of acute myocardial infarction (MI) may be related to its hypoinsulinemic effect when consumed with meals. We studied how the timing of alcohol consumption in relation to meals might affect the risk of MI in a population with relatively high regular alcohol consumption.
- We conducted a case-control study between 1995 and 1999 in Milan, Italy. Cases were 507 subjects with a first episode of nonfatal acute MI, and controls were 478 patients admitted to hospitals for other acute diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multiple logistic regression models.
- Compared with nondrinkers, an inverse trend in risk was observed when alcohol was consumed during meals only (for>or =3 drinks per day: OR = 0.50; 95% CI = 0.30-0.82). In contrast, no consistent trend in risk was found for subjects drinking outside of meals (for>or =3 drinks per day: 0.98; 0.49-1.96). The pattern of risk was similar when we considered people who drank only wine.
Question: Alcohol consumption and acute myocardial infarction: a benefit of alcohol consumed with meals?
Options:
A. yes
B. no
C. maybe
| Alcohol drinking during meals was inversely related with risk of acute MI, whereas alcohol drinking outside meals only was unrelated to risk. The answer is: A | A | Alcohol consumption and acute myocardial infarction: a benefit of alcohol consumed with meals? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- In patients with Los Angeles (LA) grade C or D oesophagitis, a positive relationship has been established between the duration of intragastric acid suppression and healing.AIM: To determine whether there is an apparent optimal time of intragastric acid suppression for maximal healing of reflux oesophagitis.
- Post hoc analysis of data from a proof-of-concept, double-blind, randomized study of 134 adult patients treated with esomeprazole (10 or 40 mg od for 4 weeks) for LA grade C or D oesophagitis. A curve was fitted to pooled 24-h intragastric pH (day 5) and endoscopically assessed healing (4 weeks) data using piecewise quadratic logistic regression.
- Maximal reflux oesophagitis healing rates were achieved when intragastric pH>4 was achieved for approximately 50-70% (12-17 h) of the 24-h period. Acid suppression above this threshold did not yield further increases in healing rates.
Question: A model of healing of Los Angeles grades C and D reflux oesophagitis: is there an optimal time of acid suppression for maximal healing?
Options:
A. yes
B. no
C. maybe
| After 4 weeks' acid-suppressive therapy for LA grade C or D oesophagitis, successful healing appears to reach a threshold above which improvements are unlikely to be achieved despite an increase in number of hours with intragastric pH>4. The answer is: A | A | A model of healing of Los Angeles grades C and D reflux oesophagitis: is there an optimal time of acid suppression for maximal healing? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- This randomized controlled study addressed whether sonographic needle guidance affected clinical outcomes of intraarticular (IA) joint injections.
- In total, 148 painful joints were randomized to IA triamcinolone acetonide injection by conventional palpation-guided anatomic injection or sonographic image-guided injection enhanced with a one-handed control syringe (the reciprocating device). A one-needle, 2-syringe technique was used, where the first syringe was used to introduce the needle, aspirate any effusion, and anesthetize and dilate the IA space with lidocaine. After IA placement and synovial space dilation were confirmed, a syringe exchange was performed, and corticosteroid was injected with the second syringe through the indwelling IA needle. Baseline pain, procedural pain, pain at outcome (2 weeks), and changes in pain scores were measured with a 0-10 cm visual analog pain scale (VAS).
- Relative to conventional palpation-guided methods, sonographic guidance resulted in 43.0% reduction in procedural pain (p<0.001), 58.5% reduction in absolute pain scores at the 2 week outcome (p<0.001), 75% reduction in significant pain (VAS pain score>or = 5 cm; p<0.001), 25.6% increase in the responder rate (reduction in VAS score>or = 50% from baseline; p<0.01), and 62.0% reduction in the nonresponder rate (reduction in VAS score<50% from baseline; p<0.01). Sonography also increased detection of effusion by 200% and volume of aspirated fluid by 337%.
Question: Does sonographic needle guidance affect the clinical outcome of intraarticular injections?
Options:
A. yes
B. no
C. maybe
| Sonographic needle guidance significantly improves the performance and outcomes of outpatient IA injections in a clinically significant manner. The answer is: A | A | Does sonographic needle guidance affect the clinical outcome of intraarticular injections? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The purpose of this study was to determine whether head and neck-specific health status domains are distinct from those assessed by general measures of quality-of-life (QOL).
- Cross-sectional study of 55 head and neck cancer patients in tertiary academic center was made. Three head and neck-specific measures,-including the Head&Neck Survey (H&NS); a brief, multi-item test which generates domain scores; and a general health measure,-were administered.
- The H&NS was highly reliable and more strongly correlated to the specific measures than to the general measure. Eating/swallowing (ES) and speech/communication (SC) were not well correlated with general health domains. Head and neck pain was highly correlated to general bodily pain (0.88, p<.0001). Despite correlations to some general health domains, appearance (AP) was not fully reflected by any other domain.
Question: Are head and neck specific quality of life measures necessary?
Options:
A. yes
B. no
C. maybe
| Head and neck-specific QOL measures are necessary and should include domains that reflect ES, SC, and AP. The answer is: A | A | Are head and neck specific quality of life measures necessary? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate feasibility of the guidelines of the Groupe Francophone de Réanimation et Urgence Pédiatriques (French-speaking group of paediatric intensive and emergency care; GFRUP) for limitation of treatments in the paediatric intensive care unit (PICU).
- A 2-year prospective survey.
- A 12-bed PICU at the Hôpital Jeanne de Flandre, Lille, France.
- Were included when limitation of treatments was expected.
- Of 967 children admitted, 55 were included with a 2-day median delay. They were younger than others (24 v 60 months), had a higher paediatric risk of mortality (PRISM) score (14 v 4), and a higher paediatric overall performance category (POPC) score at admission (2 v 1); all p<0.002. 34 (50% of total deaths) children died. A limitation decision was made without meeting for 7 children who died: 6 received do-not-resuscitate orders (DNROs) and 1 received withholding decision. Decision-making meetings were organised for 31 children, and the following decisions were made: 12 DNROs (6 deaths and 6 survivals), 4 withholding (1 death and 3 survivals), with 14 withdrawing (14 deaths) and 1 continuing treatment (survival). After limitation, 21 (31% of total deaths) children died and 10 survived (POPC score 4). 13 procedures were interrupted because of death and 11 because of clinical improvement (POPC score 4). Parents' opinions were obtained after 4 family conferences (for a total of 110 min), 3 days after inclusion. The first meeting was planned for 6 days after inclusion and held on the 7th day after inclusion; 80% of parents were immediately informed of the decision, which was implemented after half a day.
Question: Are the GFRUP's recommendations for withholding or withdrawing treatments in critically ill children applicable?
Options:
A. yes
B. no
C. maybe
| GFRUPs procedure was applicable in most cases. The main difficulties were anticipating the correct date for the meeting and involving nurses in the procedure. Children for whom the procedure was interrupted because of clinical improvement and who survived in poor condition without a formal decision pointed out the need for medical criteria for questioning, which should systematically lead to a formal decision-making process. The answer is: A | A | Are the GFRUP's recommendations for withholding or withdrawing treatments in critically ill children applicable? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Female citizens of Sami (the indigenous people of Norway) municipalities in northern Norway have a low risk of breast cancer. The objective of this study was to describe the attendance rate and outcome of the Norwegian Breast Cancer Screening Program (NBCSP) in the Sami-speaking municipalities and a control group.
- A retrospective registry-based study.
- The 8 municipalities included in the administration area of the Sami language law (Sami) were matched with a control group of 11 municipalities (non-Sami). Population data were accessed from Statistics Norway. Data regarding invitations and outcome in the NBCSP during the period 2001-2010 was derived from the Cancer Registry of Norway (CRN). The NBCSP targets women aged 50-69 years. Rates and percentages were compared using chi-square test with a p-value<0.05 as statistical significant.
- The attendance rate in the NBCSP was 78% in the Sami and 75% in the non-Sami population (p<0.01). The recall rates were 2.4 and 3.3% in the Sami and non-Sami population, respectively (p<0.01). The rate of invasive screen detected cancer was not significantly lower in the Sami group (p=0.14). The percentage of all breast cancers detected in the NBCSP among the Sami (67%) was lower compared with the non-Sami population (86%, p=0.06).
Question: Mammographic screening in Sami speaking municipalities and a control group. Are early outcome measures influenced by ethnicity?
Options:
A. yes
B. no
C. maybe
| Despite a lower risk of breast cancer, the Sami attended the NBCSP more frequently than the control group. The recall and cancer detection rate was lower among the Sami compared with the non-Sami group. The answer is: A | A | Mammographic screening in Sami speaking municipalities and a control group. Are early outcome measures influenced by ethnicity? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- This study examined changes in the use of complementary and alternative medicine (CAM) therapies by U.S. adults aged 18 years or older with chronic disease-related functional limitations between 2002 and 2007.
- The study was a cross-sectional survey.SETTING/
- The study was conducted in the United States.
- The study comprised adults aged 18 years or older with chronic disease-related functional limitations.
- Data were obtained from the 2002 and 2007 U.S. National Health Interview Survey to compare the use of 22 CAM therapies (n=9313 and n=7014, respectively). Estimates were age adjusted to the year 2000 U.S. standard population.
- The unadjusted and age-standardized prevalence of overall CAM use (22 therapies comparable between both survey years) was higher in 2007 than in 2002 (30.6% versus 26.9%, p<0.001 and 34.4% versus 30.6%, p<0.001, respectively). Adults with functional limitations that included changing and maintaining body position experienced a significant increase in CAM use between 2002 and 2007 (31.1%-35.0%, p<0.01). The use of deep breathing exercises was the most prevalent CAM therapy in both 2002 and 2007 and increased significantly during this period (from 17.9% to 19.9%, p<0.05). The use of meditation, massage, and yoga also increased significantly from 2002 and 2007 (11.0%-13.5%, p<0.01; 7.0%-10.9%, p<0.0001; and 5.1% to 6.6%, p<0.05, respectively), while the use of the Atkins diet decreased (2.2%- 1.4%, p<0.01).
Question: Has the use of complementary and alternative medicine therapies by U.S. adults with chronic disease-related functional limitations changed from 2002 to 2007?
Options:
A. yes
B. no
C. maybe
| Among U.S. adults with chronic disease-related functional limitations, the overall increase in CAM use from 2002 to 2007 was significant, particularly among those with changing and maintaining body position limitations. The answer is: A | A | Has the use of complementary and alternative medicine therapies by U.S. adults with chronic disease-related functional limitations changed from 2002 to 2007? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to determine the proportion of patients who were referred to specialist care after reporting gynecological cancer alarm symptoms to their general practitioner. We sought to investigate whether contact with specialist care was associated with lifestyle factors or socioeconomic status.
- Nationwide population-based prospective cohort study in Denmark, based on a random sample of 51 090 women aged 20 years or older from the general population. A web-based questionnaire regarding gynecological alarm symptoms and lifestyle was distributed to the invited individuals. Data about contact with specialist care were obtained from the National Patient Register and the National Health Insurance Service Registry, whereas information about socioeconomic status was collected from Statistics Denmark. Main outcome measures were percentages of patients having contact with specialist care and odds ratios (ORs) for associations between specialist care contact, lifestyle factors and socioeconomic status.
- The study included 25 866 nonpregnant women; 2957 reported the onset of at least one gynecological cancer alarm symptom, and 683 of these (23.1%) reported symptoms to their general practitioner. The proportion of individuals having contact with specialist care ranged from 39.3% (pain during intercourse) to 47.8% (bleeding during intercourse). Individuals with higher educational level had significantly higher odds of contact with a specialist (OR 1.86, 95% CI 1.17-2.95).
Question: Gynecological cancer alarm symptoms: is contact with specialist care associated with lifestyle and socioeconomic status?
Options:
A. yes
B. no
C. maybe
| Educational level influences contact with specialist care among patients with gynecological cancer alarm symptoms. Future studies should investigate inequalities in access to the secondary healthcare system. The answer is: A | A | Gynecological cancer alarm symptoms: is contact with specialist care associated with lifestyle and socioeconomic status? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The range of injury severity that can be seen within the category of type II supracondylar humerus fractures (SCHFs) raises the question whether some could be treated nonoperatively. However, the clinical difficulty in using this approach lies in determining which type II SCHFs can be managed successfully without a surgical intervention.
- We reviewed clinical and radiographic information on 259 pediatric type II SCHFs that were enrolled in a prospective registry of elbow fractures. The characteristics of the patients who were treated without surgery were compared with those of patients who were treated surgically. Treatment outcomes, as assessed by the final clinical and radiographic alignment, range of motion of the elbow, and complications, were compared between the groups to define clinical and radiographic features that related to success or failure of nonoperative management.
- During the course of treatment, 39 fractures were found to have unsatisfactory alignment with nonoperative management and were taken for surgery. Ultimately, 150 fractures (57.9%) were treated nonoperatively, and 109 fractures (42.1%) were treated surgically. At final follow-up, outcome measures of change in carrying angle, range of motion, and complications did not show clinically significant differences between treatment groups. Fractures without rotational deformity or coronal angulation and with a shaft-condylar angle of>15 degrees were more likely to be associated with successful nonsurgical treatment. A scoring system was developed using these features to stratify the severity of the injury. Patients with isolated extension deformity, but none of the other features, were more likely to complete successful nonoperative management.
Question: Type II supracondylar humerus fractures: can some be treated nonoperatively?
Options:
A. yes
B. no
C. maybe
| This study suggests that some of the less severe pediatric type II SCHFs can be successfully treated without surgery if close follow-up is achieved. Fractures with initial rotational deformity, coronal malalignment, and significant extension of the distal fragment are likely to fail a nonoperative approach. An algorithm using the initial radiographic characteristics can aid in distinguishing groups. The answer is: A | A | Type II supracondylar humerus fractures: can some be treated nonoperatively? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- All VLBW infants from January 2008 to December 2012 with positive blood culture beyond 72 hours of life were enrolled in a retrospective cohort study. Newborns born after June 2010 were treated with IgM-eIVIG, 250 mg/kg/day iv for three days in addition to standard antibiotic regimen and compared to an historical cohort born before June 2010, receiving antimicrobial regimen alone. Short-term mortality (i.e. death within 7 and 21 days from treatment) was the primary outcome. Secondary outcomes were: total mortality, intraventricular hemorrhage, necrotizing enterocolitis, periventricular leukomalacia, bronchopulmonary dysplasia at discharge.
- 79 neonates (40 cases) were enrolled. No difference in birth weight, gestational age or SNAP II score (disease severity score) were found. Significantly reduced short-term mortality was found in treated infants (22% vs 46%; p = 0.005) considering all microbial aetiologies and the subgroup affected by Candida spp. Secondary outcomes were not different between groups.
Question: Are IgM-enriched immunoglobulins an effective adjuvant in septic VLBW infants?
Options:
A. yes
B. no
C. maybe
| This hypothesis-generator study shows that IgM-eIVIG is an effective adjuvant therapy in VLBW infants with proven sepsis. Randomized controlled trials are warranted to confirm this pilot observation. The answer is: A | A | Are IgM-enriched immunoglobulins an effective adjuvant in septic VLBW infants? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Complications associated with blood transfusions have resulted in widespread acceptance of low hematocrit levels in surgical patients. However, preoperative anemia seems to be a risk factor for adverse postoperative outcomes in certain surgical patients. This study investigated the National Surgical Quality Improvement Program (NSQIP) database to determine if preoperative anemia in patients undergoing open and laparoscopic colectomies is an independent predictor for an adverse composite outcome (CO) consisting of myocardial infarction, stroke, progressive renal insufficiency or death within 30 days of operation, or for an increased hospital length of stay (LOS).
- Hematocrit levels were categorized into 4 classes: severe, moderate, mild, and no anemia. From 2005 to 2008, the NSQIP database recorded 23,348 elective open and laparoscopic colectomies that met inclusion criteria. Analyses using multivariable models, controlling for potential confounders and stratifying on propensity score, were performed.
- Compared with nonanemic patients, those with severe, moderate, and mild anemia were more likely to have the adverse CO with odds ratios of 1.83 (95% CI 1.05 to 3.19), 2.19 (95 % CI 1.63 to 2.94), and 1.49 (95% CI 1.20 to 1.86), respectively. Patients with a normal hematocrit had a reduced hospital LOS, compared with those with severe, moderate, and mild anemia (p<0.01). A history of cardiovascular disease did not significantly influence these findings.
Question: Does preoperative anemia adversely affect colon and rectal surgery outcomes?
Options:
A. yes
B. no
C. maybe
| This large multicenter database analysis suggests that the presence of severe and moderate and even mild preoperative anemia is an independent risk factor for complications and a longer hospital stay after colon surgery. The answer is: A | A | Does preoperative anemia adversely affect colon and rectal surgery outcomes? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The aim of this study was to determine whether bone scans (BS) can be avoided if pelvis was included in CT thorax and abdomen to detect bony metastases from breast cancer.
- Results of 77 pairs of CT (thorax, abdomen, and pelvis) and BS in newly diagnosed patients with metastatic breast cancer (MBC) were compared prospectively for 12 months. Both scans were blindly assessed by experienced radiologists and discussed at multidisciplinary team meetings regarding the diagnosis of bone metastases.
- CT detected metastatic bone lesions in 43 (98%) of 44 patients with bone metastases. The remaining patient had a solitary, asymptomatic bony metastasis in shaft of femur. BS was positive in all patients with bone metastases. There were 11 cases of false positive findings on BS.
Question: Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer?
Options:
A. yes
B. no
C. maybe
| Our findings suggest routine BS of patients presenting with MBC is not required if CT (thorax, abdomen, and pelvis) is performed. The answer is: A | A | Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To study the relationship between lunar position and the day of delivery; to investigate the synodic distribution of spontaneous deliveries, especially in relation to the presence of a full moon.
- Retrospective analysis of 1248 spontaneous full-term deliveries in three-year period (36 lunar months), setted at Department of Obstetrics and Gynaecology, Civil Hospital, Fano (Marche, Italy), using circular statistics techniques.
- A connection between the distribution of spontaneous full-term deliveries and the lunar month was found. The effect of the phases of the moon seems to be particularly relevant in multiparae and plurigravidae; in these cases, the mean day of delivery corresponds to the first or second day after the full moon.
Question: Does lunar position influence the time of delivery?
Options:
A. yes
B. no
C. maybe
| In this paper the effect of lunar phases on the time of delivery is shown. This influence seems to be especially relevant in the case of multiparae and plurigravidae. Nevertheless, it is too weak to allow for prediction regarding the days with the highest frequency of deliveries. The answer is: A | A | Does lunar position influence the time of delivery? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Digital tomosynthesis (DT) is a new X-ray-based imaging technique that allows image enhancement with minimal increase in radiation exposure. The purpose of this study was to compare DT with noncontrast computed tomography (NCCT) and to evaluate its potential role for the follow-up of patients with nephrolithiasis in a nonemergent setting.
- A retrospective review of patients with nephrolithiasis at our institution that underwent NCCT and DT from July 2012 to September 2013 was performed. Renal units (RUs) that did not undergo treatment or stone passage were randomly assigned to two blinded readers, who recorded stone count, size area (mm(2)), maximum stone length (mm), and location, for both DT and NCCT. Mean differences per RU were compared. Potential variables affecting stone detection rate, including stone size and body mass index (BMI), were evaluated. Interobserver agreement was determined using the intraclass correlation coefficient to measure the consistency of measurements made by the readers.
- DT and NCCT demonstrated similar stone detection rates in terms of stone counts and stone area mm(2). Of the 79 RUs assessed, 41 RUs showed exact stone counts on DT and NCCT. The mean difference in stone area was 16.5 mm(2) (-4.6 to 38.5), p = 0.121. The mean size of the largest stone on NCCT and DT was 9.27 and 8.87 mm, respectively. Stone size and BMI did not cause a significant difference in stone detection rates. Interobserver agreement showed a strong correlation between readers and adequate reproducibility.
Question: Digital Tomosynthesis: A Viable Alternative to Noncontrast Computed Tomography for the Follow-Up of Nephrolithiasis?
Options:
A. yes
B. no
C. maybe
| We found DT to be a comparable imaging modality to NCCT for the detection of intrarenal stones, without a significant effect from stone size and BMI and adequate reproducibility between multiple readers. DT appears to be an ideal alternative for following patients with nephrolithiasis due to its acceptable stone detection rates, low radiation exposure, and decreased cost compared to NCCT. The answer is: A | A | Digital Tomosynthesis: A Viable Alternative to Noncontrast Computed Tomography for the Follow-Up of Nephrolithiasis? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- It is well established that schizophrenia is associated with structural brain abnormalities, but whether these are static or progress over time remains controversial.
- A systematic review of longitudinal volumetric studies using region-of-interest structural magnetic resonance imaging in patients with schizophrenia and healthy control subjects. The percentage change in volume between scans for each brain region of interest was obtained, and data were combined using random effects meta-analysis.
- Twenty-seven studies were included in the meta-analysis, with 928 patients and 867 control subjects, and 32 different brain regions of interest. Subjects with schizophrenia showed significantly greater decreases over time in whole brain volume, whole brain gray matter, frontal gray and white matter, parietal white matter, and temporal white matter volume, as well as larger increases in lateral ventricular volume, than healthy control subjects. The time between baseline and follow-up magnetic resonance imaging scans ranged from 1 to 10 years. The differences between patients and control subjects in annualized percentage volume change were -.07% for whole brain volume, -.59% for whole brain gray matter, -.32% for frontal white matter, -.32% for parietal white matter, -.39% for temporal white matter, and +.36% for bilateral lateral ventricles.
Question: Are there progressive brain changes in schizophrenia?
Options:
A. yes
B. no
C. maybe
| These findings suggest that schizophrenia is associated with progressive structural brain abnormalities, affecting both gray and white matter. We found no evidence to suggest progressive medial temporal lobe involvement but did find evidence that this may be partly explained by heterogeneity between studies in patient age and illness duration. The causes and clinical correlates of these progressive brain changes should now be the focus of investigation. The answer is: A | A | Are there progressive brain changes in schizophrenia? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To evaluate the diagnostic accuracy of gadofosveset-enhanced magnetic resonance (MR) angiography in the assessment of carotid artery stenosis, with digital subtraction angiography (DSA) as the reference standard, and to determine the value of reading first-pass, steady-state, and "combined" (first-pass plus steady-state) MR angiograms.
- This study was approved by the local ethics committee, and all subjects gave written informed consent. MR angiography and DSA were performed in 84 patients (56 men, 28 women; age range, 61-76 years) with carotid artery stenosis at Doppler ultrasonography. Three readers reviewed the first-pass, steady-state, and combined MR data sets, and one independent observer evaluated the DSA images to assess stenosis degree, plaque morphology and ulceration, stenosis length, and tandem lesions. Interobserver agreement regarding MR angiographic findings was analyzed by using intraclass correlation and Cohen kappa coefficients. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated by using the McNemar test to determine possible significant differences (P<.05).
- Interobserver agreement regarding all MR angiogram readings was substantial. For grading stenosis, sensitivity, specificity, PPV, and NPV were, respectively, 90%, 92%, 91%, and 91% for first-pass imaging; 95% each for steady-state imaging; and 96%, 99%, 99%, and 97% for combined imaging. For evaluation of plaque morphology, respective values were 84%, 86%, 88%, and 82% for first-pass imaging; 98%, 97%, 98%, and 97% for steady-state imaging; and 98%, 100%, 100%, and 97% for combined imaging. Differences between the first-pass, steady-state, and combined image readings for assessment of stenosis degree and plaque morphology were significant (P<.001).
Question: Gadofosveset-enhanced MR angiography of carotid arteries: does steady-state imaging improve accuracy of first-pass imaging?
Options:
A. yes
B. no
C. maybe
| Gadofosveset-enhanced MR angiography is a promising technique for imaging carotid artery stenosis. Steady-state image reading is superior to first-pass image reading, but the combined reading protocol is more accurate. The answer is: A | A | Gadofosveset-enhanced MR angiography of carotid arteries: does steady-state imaging improve accuracy of first-pass imaging? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- It is not known whether common carotid intima media thickness (CIMT) can serve as a surrogate marker of cardiovascular risk among black Africans. Therefore, we examined whether CIMT differed significantly among individuals with distinct cardiovascular phenotype and correlated significantly with traditional cardiovascular risk factors in a black African population.
- CIMT was measured in 456 subjects with three distinct cardiovascular phenotypes - 175 consecutive Nigerian African stroke patients, 161 hypertensive patients without stroke and 120 normotensive non-smoking adults. For each pair of cardiovascular phenotypes, c-statistics were obtained for CIMT and traditional vascular risk factors (including age, gender, weight, waist circumference, smoking, alcohol, systolic and diastolic blood pressures, fasting plasma glucose, fasting total cholesterol). Pearson's correlation coefficients were calculated to quantify bivariate relationships.
- Bilaterally, CIMT was significantly different among the three cardiovascular phenotypes (right: p < 0.001, F = 33.8; left: p < 0.001, F = 48.6). CIMT had a higher c-statistic for differentiating stroke versus normotension (c = 0.78 right; 0.82 left, p < 0.001) and hypertension versus normotension (c = 0.65 right; 0.71 left, p < 0.001) than several traditional vascular risk factors. Bilaterally, combining all subjects, CIMT was the only factor that correlated significantly (right: 0.12 ≤ r ≤ 0.41, 0.018 ≤ p < 0.0001; left: 0.18 ≤ r ≤ 0.41, 0.005 ≤ p < 0.0001) to all the traditional cardiovascular risk factors assessed.
Question: Can common carotid intima media thickness serve as an indicator of both cardiovascular phenotype and risk among black Africans?
Options:
A. yes
B. no
C. maybe
| Our findings support CIMT as a significant indicator of both cardiovascular risk and phenotype among adult black Africans. However, specific thresholds need to be defined based on prospective studies. The answer is: A | A | Can common carotid intima media thickness serve as an indicator of both cardiovascular phenotype and risk among black Africans? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To investigate the influence of laparoscopic procedures on perisinusoidal cell function.
- In 31 patients who underwent laparoscopic cholecystectomy for symptomatic cholelithiasis, the serum levels of beta-N-acetyl hexosaminidase (beta-NAH) and hyaluronic acid (HA) were measured. Six female patients, who underwent other laparoscopic procedures, not involving the hepatobiliary system, served as controls.
- HA serum levels increased significantly in both study and control groups, while beta-NAH serum levels remained within normal values. Post-operative AST and ALT serum levels increased significantly only in the study group. No elevation of serum ALP was noted in any of our patients, and post-operative bilirubin levels did not increase in patients with normal pre-operative levels.
Question: Does laparoscopic cholecystectomy influence peri-sinusoidal cell activity?
Options:
A. yes
B. no
C. maybe
| Laparoscopic procedures caused detectable damage to Kupffer and endothelial cells as reflected by elevation of post-operative HA serum levels. The damage to the liver hepatocytes and perisinusoidal cells has no clinical significance and the laparoscopic procedure itself is the probable cause of the Kupffer and endothelial cells damage, while other mechanisms caused damage to the hepatocytes. The answer is: A | A | Does laparoscopic cholecystectomy influence peri-sinusoidal cell activity? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Blood stream infection (BSI) and the subsequent development of sepsis are among the most common infection complications occurring in severe burn patients. This study was designed to evaluate the relationship between the burn wound flora and BSI pathogens.
- Documentation of all bacterial and fungal wound and blood isolates from severe burn patients hospitalized in the burn unit and intensive care unit was obtained from medical records retrieved retrospectively from a computerized, hospital-wide database over a 13-year period. All data were recorded in relation to the Ryan score.
- Of 195 severe burn patients, 88 had at least 1 BSI episode. Transmission of the same pathogen from wound to blood was documented in 30% of the patients, with a rising BSI frequency as the Ryan score increased. There were a total of 263 bacteremic episodes in 88 study patients, 44% of blood isolates were documented previously in wound cultures, and transmission of the same pathogen from wound to blood was noted in 65% of bacteremic patients.
Question: Do Wound Cultures Give Information About the Microbiology of Blood Cultures in Severe Burn Patients?
Options:
A. yes
B. no
C. maybe
| When there is clinical suspicion of sepsis, appropriate empirical systemic antibiotic therapy should be broad spectrum and should rely on the susceptibility of the organisms from recent cultures of the burn wound surface, until the blood cultures results are completed. The answer is: A | A | Do Wound Cultures Give Information About the Microbiology of Blood Cultures in Severe Burn Patients? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The surgical treatment of diabetes had witnessed progressive development and success since the first case of pancreatic transplantation. Although this was a great step, wide clinical application was limited by several factors. Bariatric surgery such as gastric bypass is emerging as a promising option in obese patients with type 2 diabetes. The aim of this article is to explore the current application of gastric bypass in patients with type 2 diabetes and the theoretical bases of gastric bypass as a treatment option for type 1 diabetes.
- We performed a MEDLINE search for articles published from August 1955 to December 2008 using the words "surgical treatment of diabetes," "etiology of diabetes" and "gastric bypass."
- We identified 3215 studies and selected 72 relevant papers for review. Surgical treatment of diabetes is evolving from complex pancreatic and islets transplantation surgery for type 1 diabetes with critical postoperative outcome and follow-up to a metabolic surgery, including gastric bypass. Gastric bypass (no immune suppression or graft rejection) has proven to be highly effective treatment for obese patients and nonobese animals with type 2 diabetes. There are certain shared criteria between types 1 and 2 diabetes, making a selected spectrum of the disease a potential target for metabolic surgery to improve or cure diabetes.
Question: Can Roux-en-Y gastric bypass provide a lifelong solution for diabetes mellitus?
Options:
A. yes
B. no
C. maybe
| Roux-en-Y gastric bypass is a promising option for lifelong treatment of type 2 diabetes. It has the potential to improve or cure a selected spectrum of type 1 diabetes when performed early in the disease. Further animal model studies or randomized controlled trials are needed to support our conclusion. The answer is: A | A | Can Roux-en-Y gastric bypass provide a lifelong solution for diabetes mellitus? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- • Robot-assisted radical cystectomy (RARC) remains controversial in terms of oncologic outcomes, especially during the initial experience. The purpose of this study was to evaluate the impact of initial experience of robotic cystectomy programs on oncologic outcomes and overall survival.
- • Utilizing a prospectively maintained, single institution robotic cystectomy database, we identified 164 consecutive patients who underwent RARC since November 2005. • After stratification by age group, gender, pathologic T stage, lymph node status, surgical margin status, and sequential case number; we used chi-squared analyses to correlate sequential case number to operative time, surgical blood loss, lymph node yield, and surgical margin status. • We also addressed the relationship between complications and sequential case number. We then utilized Cox proportional hazard modeling and Kaplan-Meier survival analyses to correlate variables to overall mortality.
- • Sequential case number was not significantly associated with increased incidence of complications, surgical blood loss, or positive surgical margins (P= 0.780, P= 0.548, P= 0.545). Case number was, however, significantly associated with shorter operative time and mean number of lymph nodes retrieved (P<0.001, P<0.001). • Sequential case number was not significantly associated with survival; however, tumour stage, the presence of lymph node metastases, and positive surgical margins were significantly associated with death. • Although being the largest of its kind, this was a small study with short follow-up when compared to open cystectomy series.
Question: Is patient outcome compromised during the initial experience with robot-assisted radical cystectomy?
Options:
A. yes
B. no
C. maybe
| • Initial experience with RARC did not affect the incidence of positive surgical margins, operative/postoperative complications, or overall survival in a single-institution series. The answer is: B | B | Is patient outcome compromised during the initial experience with robot-assisted radical cystectomy? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole.STUDY: Sixty-two patients (19 men and 43 women; mean age, 54 years; range, 32-77 years) with heartburn and regurgitation and normal upper endoscopy findings were studied in a randomized, double-blind, placebo-controlled trial with a crossover design. There were two 5-day treatment periods with lansoprazole 60 mg once daily or placebo in random order, separated by a 9-day washout period. Reflux, total, and antacid scores were calculated for each of the treatment periods. Higher scores during the placebo period in the group given lansoprazole first than in the group given placebo first indicated a rebound aggravation of symptoms.
- The mean symptom scores during the placebo period in the groups given lansoprazole first and placebo first were as follows: reflux score, 21.5 and 17.6, respectively (not significant); total score, 11.2 and 10.3, respectively (not significant); and antacid score, 8.2 and 7.2, respectively (not significant).
Question: Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?
Options:
A. yes
B. no
C. maybe
| There is no indication of a rebound aggravation of symptoms 12 to 14 days after a 5-day treatment with lansoprazole 60 mg once daily in patients with reflux symptoms. The answer is: B | B | Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- There are 71 previously untreated patients with cytological or histological evidence of primary lung cancer who were admitted to the oncology department between November 2013 and August 2014. Forty-five healthy individuals with age, sex and BMI matching the lung cancer patients, were recruited to take part in the study as a control group. Leptin levels were measured quantitatively by using a microELISA kit.
- The serum leptin levels at diagnosis were significantly lower in lung cancer patients than those in control subjects (4.75±4.91 ng/ml, 9.67±8.02 ng/ml; p<0.001). We did not find any significant difference in leptin values related to clinicopathological parameters such as ECOG PS, weight loss, histological type, disease stage and TNM classification. Nevertheless, we demonstrated a significant correlation between serum leptin levels and BMI in lung cancer patients (correlation coefficient: 0.303; p>0.010). The analysis of serum leptin values did not show any association with the overall survival of the patients.
Question: Are serum leptin levels a prognostic factor in advanced lung cancer?
Options:
A. yes
B. no
C. maybe
| Our results showed that the serum leptin level has no prognostic indications in advanced lung cancer patients. Leptin is decreased in lung cancer, and there is lack of correlation with tumour‑related factors including prognosis. Therefore, leptin is not a useful clinical marker in lung cancer (Tab. 2, Fig. 2, Ref. 22). The answer is: B | B | Are serum leptin levels a prognostic factor in advanced lung cancer? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To study whether exercise during pregnancy reduces the risk of postnatal depression.
- Randomized controlled trial.
- Trondheim and Stavanger University Hospitals, Norway.
- Eight hundred and fifty-five pregnant women were randomized to intervention or control groups.
- The intervention was a 12 week exercise program, including aerobic and strengthening exercises, conducted between week 20 and 36 of pregnancy. One weekly group session was led by physiotherapists, and home exercises were encouraged twice a week. Control women received regular antenatal care.
- Edinburgh Postnatal Depression Scale (EPDS) completed three months after birth. Scores of 10 or more and 13 or more suggested probable minor and major depression, respectively.
- Fourteen of 379 (3.7%) women in the intervention group and 17 of 340 (5.0%) in the control group had an EPDS score of ≥10 (p=0.46), and four of 379 (1.2%) women in the intervention group and eight of 340 (2.4%) in the control group had an EPDS score of ≥13 (p=0.25). Among women who did not exercise prior to pregnancy, two of 100 (2.0%) women in the intervention group and nine of 95 (9.5%) in the control group had an EPDS score of ≥10 (p=0.03).
Question: Does exercise during pregnancy prevent postnatal depression?
Options:
A. yes
B. no
C. maybe
| We did not find a lower prevalence of high EPDS scores among women randomized to regular exercise during pregnancy compared with the control group. However, a subgroup of women in the intervention group who did not exercise regularly prior to pregnancy had a reduced risk of postnatal depression. The answer is: B | B | Does exercise during pregnancy prevent postnatal depression? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To ascertain whether level of intrauterine cocaine exposure (IUCE) is associated with early adolescent delinquent behavior, after accounting for prenatal exposures to other psychoactive substances and relevant psychosocial factors.
- Ninety-three early adolescents (12.5-14.5 years old) participating since birth in a longitudinal study of IUCE reported delinquent acts via an audio computer-assisted self-interview. Level of IUCE and exposure to cigarettes, alcohol, and marijuana were determined by maternal report, maternal and infant urine assays, and infant meconium assays at birth. Participants reported their exposure to violence on the Violence Exposure Scale for Children-Revised at ages 8.5, 9.5, and 11 years and during early adolescence, and the strictness of supervision by their caregivers during early adolescence.
- Of the 93 participants, 24 (26%) reported ≥ 3 delinquent behaviors during early adolescence. In the final multivariate model (including level of IUCE and cigarette exposure, childhood exposure to violence, and caregiver strictness/supervision) ≥ 3 delinquent behaviors were not significantly associated with level of IUCE but were significantly associated with intrauterine exposure to half a pack or more of cigarettes per day and higher levels of childhood exposure to violence, effects substantially unchanged after control for early adolescent violence exposure.
Question: Are there effects of intrauterine cocaine exposure on delinquency during early adolescence?
Options:
A. yes
B. no
C. maybe
| In this cohort, prospectively ascertained prenatal exposure to cigarettes and childhood exposure to violence are associated with self-reported delinquent behaviors during early adolescence. Contrary to initial popular predictions, intrauterine cocaine is not a strong predictor of adolescent delinquent behaviors in this cohort. The answer is: B | B | Are there effects of intrauterine cocaine exposure on delinquency during early adolescence? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Treatment of elderly cancer patients has gained importance. One question regarding the treatment of metastatic spinal cord compression (MSCC) is whether elderly patients benefit from surgery in addition to radiotherapy? In attempting to answer this question, we performed a matched-pair analysis comparing surgery followed by radiotherapy to radiotherapy alone.
- Data from 42 elderly (age> 65 years) patients receiving surgery plus radiotherapy (S + RT) were matched to 84 patients (1:2) receiving radiotherapy alone (RT). Groups were matched for ten potential prognostic factors and compared regarding motor function, local control, and survival. Additional matched-pair analyses were performed for the subgroups of patients receiving direct decompressive surgery plus stabilization of involved vertebrae (DDSS, n = 81) and receiving laminectomy (LE, n = 45).
- Improvement of motor function occurred in 21% after S + RT and 24% after RT (p = 0.39). The 1-year local control rates were 81% and 91% (p = 0.44), while the 1-year survival rates were 46% and 39% (p = 0.71). In the matched-pair analysis of patients receiving DDSS, improvement of motor function occurred in 22% after DDSS + RT and 24% after RT alone (p = 0.92). The 1-year local control rates were 95% and 89% (p = 0.62), and the 1-year survival rates were 54% and 43% (p = 0.30). In the matched-pair analysis of patients receiving LE, improvement of motor function occurred in 20% after LE + RT and 23% after RT alone (p = 0.06). The 1-year local control rates were 50% and 92% (p = 0.33). The 1-year survival rates were 32% and 32% (p = 0.55).
Question: Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
Options:
A. yes
B. no
C. maybe
| Elderly patients with MSCC did not benefit from surgery in addition to radiotherapy regarding functional outcome, local control of MSCC, or survival. The answer is: B | B | Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- This was a study to compare the results of mitral valve (MV) repair and MV replacement for the treatment of functional mitral regurgitation (MR) in advanced dilated and ischemic cardiomyopathy (DCM).
- One-hundred and thirty-two patients with severe functional MR and systolic dysfunction (mean ejection fraction 0.32 ± 0.078) underwent mitral surgery in the same time frame. The decision to replace rather than repair the MV was taken when 1 or more echocardiographic predictors of repair failure were identified at the preoperative echocardiogram. Eighty-five patients (64.4%) received MV repair and 47 patients (35.6%) received MV replacement. Preoperative characteristics were comparable between the 2 groups. Only ejection fraction was significantly lower in the MV repair group (0.308 ± 0.077 vs 0.336 ± 0.076, p = 0.04).
- Hospital mortality was 2.3% for MV repair and 12.5% for MV replacement (p = 0.03). Actuarial survival at 2.5 years was 92 ± 3.2% for MV repair and 73 ± 7.9% for MV replacement (p = 0.02). At a mean follow-up of 2.3 years (median, 1.6 years), in the MV repair group LVEF significantly increased (from 0.308 ± 0.077 to 0.382 ± 0.095, p<0.0001) and LV dimensions significantly decreased (p = 0.0001). On the other hand, in the MV replacement group LVEF did not significantly change (from 0.336 ± 0.076 to 0.31 ± 0.11, p = 0.56) and the reduction of LV dimensions was not significant. Mitral valve replacement was identified as the only predictor of hospital (odds ratio, 6; 95% confidence interval, 1.1 to 31; p = 0.03) and overall mortality (hazard ratio, 3.1; 95% confidence interval, 1.1 to 8.9; p = 0.02).
Question: Mitral replacement or repair for functional mitral regurgitation in dilated and ischemic cardiomyopathy: is it really the same?
Options:
A. yes
B. no
C. maybe
| In patients with advanced dilated and ischemic cardiomyopathy and severe functional MR, MV replacement is associated with higher in-hospital and late mortality compared with MV repair. Therefore, mitral repair should be preferred whenever possible in this clinical setting. The answer is: B | B | Mitral replacement or repair for functional mitral regurgitation in dilated and ischemic cardiomyopathy: is it really the same? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Compared with computed tomography (CT) and magnetic resonance imaging (MRI), positron emission tomography (PET) may have additional value in the assessment of primary and recurrent cervical cancer. However, the degree of tumour uptake of (18)F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake is sometimes influenced by diabetes mellitus (DM). Therefore, we conducted this prospective study to compare the diagnostic ability of FDG-PET in patients with cervical cancer complicated by DM and those without DM.
- Patients with untreated locally advanced primary or clinically curable recurrent cervical carcinoma were enrolled. Both FDG-PET and MRI/CT scans were performed within 2 weeks. Patients were categorised into the following groups: hyperglycaemic DM (fasting blood sugar>126 mg/dl), euglycaemic DM and non-DM. The lesions were confirmed histologically or by clinical follow-up. The receiver operating characteristic curve method, with calculation of the area under the curve (AUC), was used to evaluate the discriminative power.
- From February 2001 to January 2003, 219 patients (75 with primary and 144 with recurrent cervical cancer) were eligible for analysis. Sixteen had hyperglycaemic DM, 12 had euglycaemic DM and 191 were in the non-DM group. The diagnostic power of PET in the hyperglycaemic DM, euglycaemic DM and non-DM groups did not differ significantly with regard to the identification of either metastatic lesions (AUC, 0.967/0.947/0.925, P>0.05) or primary tumours/local recurrence (AUC, 0.950/0.938/0.979, P>0.05). Considering all DM patients, PET showed a significantly higher detection power than MRI/CT scans in respect of metastatic lesions (AUC=0.956 vs 0.824, P=0.012).
Question: Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer?
Options:
A. yes
B. no
C. maybe
| In comparison with its accuracy in non-DM patients, the accuracy of PET in cervical cancer patients with mild to moderate DM was not significantly reduced. The answer is: B | B | Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Delayed gastric emptying (DGE) is the most frequent postoperative complication after pylorus-preserving pancreaticoduodenectomy (PPPD). This prospective, non-randomized study was undertaken to determine whether the incidence of DGE may be reduced by modifying the original reconstructive anatomy with a retrocolic duodenojejunostomy towards an antecolic duodenojejunostomy.
- The study was comprised of 51 patients who underwent PPPD between August 1994 and November 1997. The operation was carried out as originally described but was modified by performing the duodenojejunostomy antecolically. Clinical data were recorded prospectively, with special regard to DGE.
- After PPPD, the nasogastric tube could be removed at a median of 2 days (range 1-22 days) postoperatively; in two patients, the nasogastric tube was reinserted because of vomiting and nausea. A liquid diet was started at a median of 5 days (3-11 days); the patients were able to tolerate a full, regular diet at a median of 10 days (7-28 days). The overall incidence of DGE was 12% (n=6). No postoperative complications other than DGE were exhibited by 36 patients (71%). In this group, DGE was only seen in one patient (3%). In the second group, where postoperative complications other than DGE occurred (n=15), five patients (30%) exhibited DGE (P=0.002).
Question: Is delayed gastric emptying following pancreaticoduodenectomy related to pylorus preservation?
Options:
A. yes
B. no
C. maybe
| DGE after PPPD seems to be of minor clinical importance following uncomplicated surgery. When taking the results into consideration, it can be said that, despite the lack of a control group, antecolic duodenojejunostomy might be the key to a low incidence of DGE after PPPD. In our experience, DGE is linked to the occurrence of other postoperative complications rather than to pylorus preservation. The answer is: B | B | Is delayed gastric emptying following pancreaticoduodenectomy related to pylorus preservation? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To investigate whether the presence of hippocampal atrophy (HCA) on MRI in Alzheimer's disease (AD) leads to a more rapid decline in cognitive function. To investigate whether cognitively unimpaired controls and depressed subjects with HCA are at higher risk than those without HCA of developing dementia.
- A prospective follow-up of subjects from a previously reported MRI study.
- Melbourne, Australia.
- Five controls with HCA and five age-matched controls without HCA, seven depressed subjects with HCA and seven without HCA, and 12 subjects with clinically diagnosed probable AD with HCA and 12 without HCA were studied. They were followed up at approximately 2 years with repeat cognitive testing, blind to initial diagnosis and MRI result.
- HCA was rated by two radiologists blind to cognitive test score results. Cognitive assessment was by the Cambridge Cognitive Examination (CAMCOG).
- No significant differences in rate of cognitive decline, mortality or progression to dementia were found between subjects with or without HCA.
Question: Does hippocampal atrophy on MRI predict cognitive decline?
Options:
A. yes
B. no
C. maybe
| HCA was not found to be a predictor of subsequent cognitive decline in this series. The answer is: B | B | Does hippocampal atrophy on MRI predict cognitive decline? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- The purpose of this study was to determine whether there is an association between skewed X-inactivation and recurrent spontaneous abortion in a large, well-defined sample of women with recurrent loss.
- X-chromosome inactivation patterns were compared in 5 groups of women. Group 1 (recurrent spontaneous abortion) consisted of 357 women with 2 or more spontaneous losses. In group 2 (infertility), there were 349 subjects from infertility practices recruited at the time of a positive serum beta-human chorionic gonadotropin. Group 3 (spontaneous abortion) women (n = 81) were recruited at the time of an ultrasound diagnosis of an embryonic demise or an anembryonic gestation. Groups 4 (primiparous) and 5 (multiparous) were healthy pregnant subjects previously enrolled in another study to determine the incidence and cause of pregnancy complications, such as preeclampsia and intrauterine growth restriction. The Primiparous group included 114 women in their first pregnancy, whereas the Multiparous group consisted of 79 women with 2 or more pregnancies but without pregnancy loss.
- The rate of extreme skewing (90% or greater) in the recurrent spontaneous abortion population was 8.6%, and not statistically different from any of the other groups, except the Primiparous group (1.0%, P<.01). The incidence of X-inactivation skewing of 90% or greater was no different whether there had been at least 1 live birth (9.9%), or no previous live births and at least 3 losses (5.6%, P>.05). When age and skewing of 90% or greater are compared, subjects with extreme skewing have a mean age of 2 years older than those without extreme skewing (P<.05).
Question: Recurrent spontaneous abortion and skewed X-inactivation: is there an association?
Options:
A. yes
B. no
C. maybe
| Skewed X-inactivation is not associated with recurrent spontaneous abortion but is associated with increasing maternal age. The answer is: B | B | Recurrent spontaneous abortion and skewed X-inactivation: is there an association? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To determine survival among patients with epithelial ovarian carcinoma (EOC) who underwent a second-look laparotomy (SLL) and those refusing the procedure. Also to analyze factor(s) influencing the survival of the patients.
- Medical records were reviewed of patients with advanced EOC who were clinically free of disease after primary surgery and platinum-based chemotherapy between January 1, 1992, and December 31, 1998. All of them were offered SLL. Measurement outcomes include patient survival and disease-free survival.
- There were 50 patients with clinically complete remission after chemotherapy. Sixteen patients underwent SLL, and thirty-four patients refused the procedure (NSLL). Seven patients (43.8%) were reported to have positive SLL. After the median follow-up time of 35 months, 12 patients had died, and 5 patients were lost to follow-up. The median survival time for patients with SLL was about 60 months. Five-year survival rates of patients in the SLL, and NSLL groups were 37 per cent (95%CI = 7%-69%), and 88 per cent (95%CI = 65%-96%) respectively (P<0.001). The median time to relapse was about 25 months for patients with negative SLL. Five-year disease-free survival rates of patients in the negative SLL, and NSLL groups were 28 per cent (95%CI = 4%-59%), and 54 per cent (95%CI = 34%-70%) respectively (P=0.251). By Cox regression analysis, tumor grade was the only significant prognostic factor influencing patients' survival (HR = 6, 95%CI of HR = 1.2-34.2).
Question: Advanced epithelial ovarian carcinoma in Thai women: should we continue to offer second-look laparotomy?
Options:
A. yes
B. no
C. maybe
| The second-look laparotomy doesn't have a favorable impact on overall and disease-free survival. Tumor grade is the only independent prognostic variable for survival of the patients. The answer is: B | B | Advanced epithelial ovarian carcinoma in Thai women: should we continue to offer second-look laparotomy? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Treatment delays in breast cancer are generally thought to affect prognosis but the impact on survival remains unclear. Indicators for breast cancer care include time to primary treatment. The purpose of this study was to evaluate whether time to primary treatment (TPT) in breast cancer impacts survival.
- A total of 648 breast cancer patients treated in the University Malaya Medical Center (UMMC), Malaysia between 2004 and 2005 were included in the study. TPT was calculated from the date of pathological diagnosis to the date of primary treatment. Mortality data was obtained from the National Registry of Births and Deaths. Last date of follow-up was November 2010.
- Median TPT was 18 days. Majority 508 (69.1%) of the patients received treatment within 30 days after diagnosis. The majority was surgically treated. Ethnicity (p=0.002) and stage at presentation (p=0.007) were significantly associated with delayed TPT. Malay ethnicity had delayed TPT compared to the Chinese; Hazard Ratio (HR) 1.9 (Confidence Interval (CI) 1.237, 2.987). Delayed TPT did not affect overall survival on univariate and multivariate analyses.
Question: Delays in time to primary treatment after a diagnosis of breast cancer: does it impact survival?
Options:
A. yes
B. no
C. maybe
| Time to primary treatment after a diagnosis of breast cancer had no impact on overall survival. Further studies on care before diagnosis are important in drawing up meaningful quality indicators. The answer is: B | B | Delays in time to primary treatment after a diagnosis of breast cancer: does it impact survival? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Epidemiologic findings support a positive association between asthma and obesity.
- Determine whether obesity or increasing level of body mass index (BMI) are associated with worse asthma control in an ethnically diverse urban population.
- Cross-sectional assessment of asthma control was performed in patients with asthma recruited from primary care offices by using 4 different validated asthma control questionnaires: the Asthma Control and Communication Instrument (ACCI), the Asthma Control Test (ACT), the Asthma Control Questionnaire (ACQ), and the Asthma Therapy Assessment Questionnaire (ATAQ). Multiple linear regression analysis was performed to evaluate the association between obesity and increasing BMI level and asthma control.
- Of 292 subjects with a mean age of 47 years, the majority were women (82%) and African American (67%). There was a high prevalence of obesity with 63%, with only 15% normal weight. The mean score from all 4 questionnaires showed an average suboptimal asthma control (mean score/maximum possible score): ACCI (8.3/19), ACT (15.4/25), ACQ (2.1/6), and ATAQ (1.3/4). Regression analysis showed no association between obesity or increasing BMI level and asthma control using all 4 questionnaires. This finding persisted even after adjusting for FEV(1), smoking status, race, sex, selected comorbid illnesses, and long-term asthma controller use.
Question: Does higher body mass index contribute to worse asthma control in an urban population?
Options:
A. yes
B. no
C. maybe
| Using 4 validated asthma control questionnaires, we failed to find an association between obesity and asthma control in an urban population with asthma. Weight loss may not be an appropriate strategy to improve asthma control in this population. The answer is: B | B | Does higher body mass index contribute to worse asthma control in an urban population? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Anastomotic leakage is the most threatening early complication in sphincter-preserving rectal cancer surgery. While the oncological consequences have been well examined, only few data exist about the functional outcome.
- We investigated continence function in 150 patients after curative sphincter-preserving rectal cancer surgery. Functional results were compared in 22 patients with a clinically relevant anastomotic leakage, confirmed radiologically or endoscopically, and 128 patients with uneventful recovery. Evaluation of continence function was based on the Cleveland Clinic Continence Score and was examined in all patients with anastomotic leakage and in 111 patients without complications 107+/-46 weeks postoperatively. Additionally, 14 patients with anastomotic leakage and 58 patients with uneventful recovery underwent anorectal manometry 26+/-15 weeks postoperatively.
- The continence score in patients after anastomotic leakage did not differ significantly from that in patients without complications. Sphincter function was similar. Maximum tolerable volume and rectal compliance were slightly but not significantly worse after leakage.
Question: Does anastomotic leakage affect functional outcome after rectal resection for cancer?
Options:
A. yes
B. no
C. maybe
| Continence function remained undisturbed after anastomotic leakage due to rectal resection The answer is: B | B | Does anastomotic leakage affect functional outcome after rectal resection for cancer? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- There is a positive association between chronic inflammation and the risk of cardiovascular disease, but whether there is an association between C-reactive protein (CRP) and carotid atherosclerosis is controversial. We investigated the relationship between high-sensitivity CRP (hsCRP) levels and carotid intima-media thickness (IMT) in healthy Koreans.
- We measured hsCRP levels, the carotid IMT, and conventional cardiovascular risk factors including obesity parameters, blood pressure, lipid profiles, insulin resistance, and smoking habits in 820 volunteers (35-79 years old) in a cross-sectional study.
- Higher hsCRP quartile groups had higher mean IMTs, as compared with the lowest quartile (P<0.001 for the trend across quartiles). However, after adjustment for age, the relationship between hsCRP level and IMT was substantially weaker (P = 0.018). After additional adjustments for conventional cardiovascular risk factors, no significant association was observed (P = 0.548). The unadjusted risk for a high carotid IMT value (>or = 1.0 mm) was also positively related to hsCRP quartile, but this relationship was not significant after adjustment for age and other cardiovascular risk factors.
Question: Is high-sensitivity C-reactive protein associated with carotid atherosclerosis in healthy Koreans?
Options:
A. yes
B. no
C. maybe
| Both hsCRP levels and the carotid IMT were strongly correlated with conventional cardiovascular risk factors, but there was no independent association between hsCRP levels and carotid IMT in healthy Korean adults. The answer is: B | B | Is high-sensitivity C-reactive protein associated with carotid atherosclerosis in healthy Koreans? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Trauma patients who require therapeutic anticoagulation pose a difficult treatment problem. The purpose of this study was to determine: (1) the incidence of complications using therapeutic anticoagulation in trauma patients, and (2) if any patient factors are associated with these complications.
- An 18-month retrospective review was performed on trauma patients>or= 15 years old who received therapeutic anticoagulation using unfractionated heparin (UH) and/or fractionated heparin (FH). Forty different pre-treatment and treatment patient characteristics were recorded. Complications of anticoagulation were documented and defined as any unanticipated discontinuation of the anticoagulant for bleeding or other adverse events.
- One-hundred-fourteen trauma patients were initiated on therapeutic anticoagulation. The most common indication for anticoagulation was deep venous thrombosis (46%). Twenty-four patients (21%) had at least 1 anticoagulation complication. The most common complication was a sudden drop in hemoglobin concentration requiring blood transfusion (11 patients). Five patients died (4%), 3 of whom had significant hemorrhage attributed to anticoagulation. Bivariate followed by logistic regression analysis identified chronic obstructive pulmonary disease (OR = 9.2, 95%CI = 1.5-54.7), UH use (OR = 3.8, 95%CI = 1.1-13.0), and lower initial platelet count (OR = 1.004, 95%CI = 1.000-1.008) as being associated with complications. Patients receiving UH vs. FH differed in several characteristics including laboratory values and anticoagulation indications.
Question: Therapeutic anticoagulation in the trauma patient: is it safe?
Options:
A. yes
B. no
C. maybe
| Trauma patients have a significant complication rate related to anticoagulation therapy, and predicting which patients will develop a complication remains unclear. Prospective studies are needed to determine which treatment regimen, if any, is appropriate to safely anticoagulate this high risk population. The answer is: B | B | Therapeutic anticoagulation in the trauma patient: is it safe? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Medical units at an academic tertiary referral hospital in Southern India.
- To investigate the impact of solid culture on Löwenstein-Jensen medium on clinical decision making.
- In a retrospective review of 150 culture-positive and 150 culture-negative consecutively sampled tuberculosis (TB) suspects, treatment decisions were analysed at presentation, after the availability of culture detection results and after the availability of drug susceptibility testing (DST) culture results.
- A total of 124 (82.7%) culture-positive patients and 35 (23.3%) culture-negative patients started anti-tuberculosis treatment prior to receiving their culture results; 101 patients (33.7%) returned for their results; two (1.3%) initiated treatment based on positive culture and no culture-negative patients discontinued treatment. DST was performed on 119 (79.3%) positive cultures: 30 (25.2%) showed any resistance, eight (6.7%) showed multidrug resistance and one (0.84%) showed extensively drug-resistant TB. Twenty-eight patients (23.5%) returned for their DST results. Based on DST, treatment was modified in four patients (3.4%).
Question: Does solid culture for tuberculosis influence clinical decision making in India?
Options:
A. yes
B. no
C. maybe
| Using solid culture, 150 cultures need to be tested for one treatment modification and 30 for DST. The cost of the widespread application of culture will need to be balanced against its impact on treatment decisions in India. The answer is: C | C | Does solid culture for tuberculosis influence clinical decision making in India? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Health services often spend more on safety interventions than seems cost-effective. This study investigates whether the public value safety-related health care improvements more highly than the same improvements in contexts where the health care system is not responsible.
- An online survey was conducted to elicit the relative importance placed on preventing harms caused by 1) health care (hospital-acquired infections, drug administration errors, injuries to health care staff), 2) individuals (personal lifestyle choices, sports-related injuries), and 3) nature (genetic disorders). Direct valuations were obtained from members of the public by using a person trade-off or "matching" method. Participants were asked to choose between two preventative interventions of equal cost and equal health benefit per person for the same number of people, but differing in causation. If participants indicated a preference, their strength of preference was measured by using person trade-off.
- Responses were obtained from 1030 people, reflecting the sociodemographic mix of the UK population. Participants valued interventions preventing hospital-acquired infections (1.31) more highly than genetic disorders (1.0), although drug errors were valued similarly to genetic disorders (1.07), and interventions to prevent injury to health care staff were given less weight than genetic disorders (0.71). Less weight was also given to interventions related to lifestyle (0.65) and sports injuries (0.41).
Question: Does responsibility affect the public's valuation of health care interventions?
Options:
A. yes
B. no
C. maybe
| Our results suggest that people do not attach a simple fixed premium to "safety-related" interventions but that preferences depend more subtly on context. The use of the results of such public preference surveys to directly inform policy would therefore be premature. The answer is: C | C | Does responsibility affect the public's valuation of health care interventions? | [
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You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Cutaneous melanoma in nonwhite persons has a manifestation and a prognosis that are different than those of cutaneous melanoma in white persons.
- Case series.
- Tertiary care university-affiliated community medical center located in a multiethnic state in which white persons are a minority of the population.
- Consecutive series of 357 patients with melanoma seen between January 1994 and August 2003.
- Ethnicity, age, sex, primary site, tumor thickness, nodal status, stage at diagnosis, and survival.
- There were 208 men and 149 women who ranged in age from 15 to 93 years (mean, 58 years). Twenty-two patients initially had unknown primary sites. Of these 357 patients, 67 (18.7%) were nonwhite. There was no statistically significant difference in the age (P =.10) or sex (P =.57) distribution of these 2 populations. Nonwhite patients at initial diagnosis had thicker tumors (P =.002), more frequently had ulcerated primary tumors (P<.001), more frequently had positive nodes (P =.004), and were at a more advanced stage (P =.002) than their white counterparts. The anatomic distribution between the 2 populations was significantly different (P<.001), with a high incidence of melanoma on the sole and subungual locations and a substantially less frequent occurrence on the head and neck, trunk, and extremities in the nonwhite population when compared with the white population. The overall survival rate of the nonwhite patients was significantly worse than that of the white patients, but when stratified by stage at initial diagnosis, there was no difference in outcome.
Question: Cutaneous melanoma in a multiethnic population: is this a different disease?
Options:
A. yes
B. no
C. maybe
| In a multiethnic population, cutaneous melanoma in nonwhite persons is unusual but not rare. Although the diagnoses are distinctly different at initial examinations, suggesting a potential biological component, stage-for-stage outcomes are similar between white and nonwhite persons and suggest a need for early diagnostic interventions with unusual pigmented lesions in nonwhite persons. The answer is: C | C | Cutaneous melanoma in a multiethnic population: is this a different disease? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- Routine intraoperative frozen section (FS) of sentinel lymph nodes (SLN) can detect metastatic disease, allowing immediate axillary dissection and avoiding the need for reoperation. Routine FS is also costly, increases operative time, and is subject to false-negative results. We examined the benefit of routine intraoperative FS among the first 1000 patients at Memorial Sloan Kettering Cancer Center who had SLN biopsy for breast cancer.
- We performed SLN biopsy with intraoperative FS in 890 consecutive breast cancer patients, none of whom had a back-up axillary dissection planned in advance. Serial sections and immunohistochemical staining for cytokeratins were performed on all SLN that proved negative on FS. The sensitivity of FS was determined as a function of (1) tumor size and (2) volume of metastatic disease in the SLN, and the benefit of FS was defined as the avoidance of a reoperative axillary dissection.
- The sensitivity of FS ranged from 40% for patients with Tla to 76% for patients with T2 cancers. The volume of SLN metastasis was highly correlated with tumor size, and FS was far more effective in detecting macrometastatic disease (sensitivity 92%) than micrometastases (sensitivity 17%). The benefit of FS in avoiding reoperative axillary dissection ranged from 4% for Tla (6 of 143) to 38% for T2 (45 of 119) cancers.
Question: Is routine intraoperative frozen-section examination of sentinel lymph nodes in breast cancer worthwhile?
Options:
A. yes
B. no
C. maybe
| In breast cancer patients having SLN biopsy, the failure of routine intraoperative FS is largely the failure to detect micrometastatic disease. The benefit of routine intraoperative FS increases with tumor size. Routine FS may not be indicated in patients with the smallest invasive cancers. The answer is: C | C | Is routine intraoperative frozen-section examination of sentinel lymph nodes in breast cancer worthwhile? | [
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] |
You are a biomedical QA model evaluator. Your task is to read the context carefully, answer the given question with one of the provided options (A, B, C).
Based on this comparison, indicate whether your prediction is correct or incorrect.
Context:
- To understand which genes are really involved in the implantation process, we planned to study the gene basal expression profile during the window of implantation (WOI) of patients who became pregnant in a subsequent ICSI cycle.
- Women attending their first ICSI cycle at ANDROS Day Surgery for severe male factor infertility were included in the study. An endometrial biopsy was performed during the WOI, in one of the last two cycles before the ICSI cycle. Forty-seven selected gene profiles were analyzed using Low Density Array technology. Only biopsies from women who subsequently became pregnant were evaluated, to exclude any bias regarding embryo viability and embryo transfer difficulties.
- Fifteen patients were included in the analysis as they became pregnant after ICSI procedure. Four of 47 selected genes were excluded from the analysis. Of the 43 genes analyzed, only 6 genes (VEGFA, PLA2G2A, ALPL, LIF, NNMT and STC1) showed a statistically uniform expression among patients who subsequently became pregnant. For all the other genes analyzed there were considerable differences in their expression levels amongst women who subsequently became pregnant.
Question: Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle?
Options:
A. yes
B. no
C. maybe
| Our data suggest that very few genes, which change their expression level during the WOI, show a quantitative homogeneous expression in endometrially-receptive patients. In conclusion, in this study only six genes showed a homogeneous expression, and are probably involved in embryo implantation mechanisms. The answer is: C | C | Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle? | [
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Subsets and Splits