text
stringlengths
7
1.01k
negative regulation of apoptotic process negative regulation of DNA-templated transcription negative regulation of intracellular transport protein refolding response to heat
apoptotic process involved in morphogenesis cellular response to gamma radiation lens development in camera-type eye microtubule polymerization or depolymerization muscle contraction muscle organ development negative regulation of amyloid fibril formation negative regulation of apoptotic process negative regulation of cell growth negative regulation of DNA-templated transcription negative regulation of gene expression negative regulation of intracellular transport negative regulation of protein-containing complex assembly negative regulation of reactive oxygen species metabolic process protein folding protein refolding protein stabilization regulation of programmed cell death response to estradiol response to heat response to hydrogen peroxide response to hypoxia stress-activated MAPK cascade tubulin complex assembly
behavioral response to starvation chaperone-mediated protein folding defense response to bacterium defense response to fungus determination of adult lifespan protein refolding response to heat
epidermis development epithelial cell differentiation hair cycle intermediate filament bundle assembly intermediate filament organization keratinocyte differentiation stem cell differentiation
cellular response to calcium ion epidermis development epithelial cell differentiation intermediate filament organization keratinocyte development keratinocyte differentiation positive regulation of epidermis development protein heterotetramerization stem cell differentiation
antimicrobial humoral immune response mediated by antimicrobial peptide cell differentiation defense response to Gram-positive bacterium intermediate filament organization keratinization killing of cells of another organism morphogenesis of an epithelium negative regulation of entry of bacterium into host cell positive regulation of cell population proliferation wound healing
intermediate filament organization skeletal muscle organ development
intermediate filament organization
cellular response to lipopolysaccharide cellular response to muramyl dipeptide intermediate filament organization
cellular response to lipopolysaccharide cellular response to muramyl dipeptide intermediate filament organization intermediate filament polymerization
cellular response to hypoxia cellular senescence DNA double-strand break attachment to nuclear envelope establishment or maintenance of microtubule cytoskeleton polarity heterochromatin formation muscle organ development negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of cell population proliferation negative regulation of extrinsic apoptotic signaling pathway negative regulation of mesenchymal cell proliferation negative regulation of release of cytochrome c from mitochondria nuclear envelope organization nuclear migration nuclear pore localization positive regulation of gene expression protein import into nucleus protein localization protein localization to nuclear envelope protein localization to nucleus regulation of cell migration regulation of protein localization to nucleus regulation of protein stability regulation of telomere maintenance ventricular cardiac muscle cell development
anterograde axonal transport axonal transport of mitochondrion intermediate filament organization neurofilament bundle assembly retrograde axonal transport
anterograde axonal transport axonal transport of mitochondrion axonogenesis intermediate filament bundle assembly intermediate filament organization locomotion microtubule cytoskeleton organization motor neuron apoptotic process negative regulation of motor neuron apoptotic process negative regulation of neuron apoptotic process neurofilament bundle assembly neurofilament cytoskeleton organization neuromuscular process controlling balance neuron projection morphogenesis peripheral nervous system axon regeneration positive regulation of axonogenesis postsynaptic modulation of chemical synaptic transmission regulation of axon diameter regulation of synapse maturation retrograde axonal transport
microtubule cytoskeleton organization mitotic cell cycle
microtubule cytoskeleton organization mitotic cell cycle
microtubule cytoskeleton organization mitotic cell cycle
cytoplasmic microtubule organization cytoskeleton organization microtubule cytoskeleton organization microtubule-based process mitotic cell cycle mitotic spindle assembly mitotic spindle elongation positive regulation of intracellular protein transport response to antibiotic
mitotic cytokinesis
mitotic cytokinesis
phagocytosis response to chemical
regulation of muscle contraction skeletal muscle contraction
establishment of protein localization to vacuole mitotic cytokinesis negative regulation of asexual reproduction negative regulation of proteolysis plasma membrane repair positive regulation of positive chemotaxis to cAMP positive regulation of sequestering of calcium ion protein export from nucleus regulation of sorocarp stalk cell differentiation
actomyosin structure organization myofibril assembly
muscle contraction skeletal muscle tissue development
myofibril assembly
cochlea development excitatory chemical synaptic transmission gene expression inhibitory chemical synaptic transmission
cochlea development response to wounding
adaptive thermogenesis astrocyte activation axonogenesis cell adhesion learning or memory negative regulation of monocyte chemotactic protein-1 production phosphorylation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of complement activation regulation of translation sympathetic neuron projection extension
regulation of heart contraction
actin filament capping actin filament depolymerization actin filament polymerization actin filament severing actin polymerization or depolymerization barbed-end actin filament capping cellular response to epidermal growth factor stimulus cellular response to hepatocyte growth factor stimulus cytoplasmic actin-based contraction involved in cell motility epidermal growth factor receptor signaling pathway positive regulation of actin filament bundle assembly positive regulation of cell migration positive regulation of epithelial cell migration regulation of actin nucleation regulation of cell shape regulation of lamellipodium morphogenesis regulation of wound healing response to bacterium
cholesterol metabolic process lipid transport lipoprotein metabolic process peptidyl-methionine modification phosphatidylcholine metabolic process positive regulation of cholesterol efflux positive regulation of phagocytosis positive regulation of phospholipid efflux protein oxidation protein stabilization regulation of intestinal cholesterol absorption
cholesterol efflux cholesterol homeostasis cholesterol metabolic process high-density lipoprotein particle remodeling hydrogen peroxide catabolic process innate immune response in mucosa leukocyte cell-cell adhesion lipid catabolic process lipid homeostasis lipid transport lipoprotein metabolic process negative regulation of plasma lipoprotein oxidation peripheral nervous system axon regeneration phosphatidylcholine metabolic process phospholipid efflux positive regulation of fatty acid biosynthetic process positive regulation of triglyceride catabolic process protein-lipid complex assembly regulation of cholesterol transport regulation of intestinal cholesterol absorption removal of superoxide radicals response to food response to lipid hydroperoxide response to stilbenoid response to triglyceride reverse cholesterol transport triglyceride homeostasis very-low-density lipoprotein particle remodeling
cholesterol homeostasis cholesterol metabolic process cholesterol transport high-density lipoprotein particle assembly high-density lipoprotein particle remodeling lipoprotein metabolic process low-density lipoprotein particle remodeling peptidyl-methionine modification positive regulation of interleukin-8 production positive regulation of phagocytosis protein oxidation protein stabilization triglyceride-rich lipoprotein particle remodeling
cholesterol efflux cholesterol metabolic process chylomicron remnant clearance high-density lipoprotein particle remodeling lipid metabolic process lipoprotein metabolic process negative regulation of cholesterol transport negative regulation of fatty acid biosynthetic process negative regulation of lipid catabolic process negative regulation of lipid metabolic process negative regulation of lipoprotein lipase activity negative regulation of phosphatidylcholine catabolic process negative regulation of receptor-mediated endocytosis negative regulation of very-low-density lipoprotein particle clearance phospholipid efflux plasma lipoprotein particle remodeling regulation of cholesterol transport triglyceride metabolic process very-low-density lipoprotein particle assembly very-low-density lipoprotein particle clearance
cholesterol efflux cholesterol homeostasis chylomicron remnant clearance chylomicron remodeling high-density lipoprotein particle clearance lipid catabolic process negative regulation of cholesterol transport negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis negative regulation of very-low-density lipoprotein particle clearance phospholipid efflux positive regulation of fatty acid biosynthetic process positive regulation of lipoprotein lipase activity positive regulation of phospholipase activity positive regulation of phospholipid catabolic process positive regulation of triglyceride catabolic process positive regulation of very-low-density lipoprotein particle remodeling reverse cholesterol transport triglyceride homeostasis triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling
negative regulation of supramolecular fiber organization protein stabilization response to 11-deoxycorticosterone response to dehydroepiandrosterone response to estradiol response to growth hormone response to progesterone
defense response to bacterium response to 11-deoxycorticosterone response to dehydroepiandrosterone response to estradiol response to growth hormone response to progesterone
negative regulation of canonical NF-kappaB signal transduction negative regulation of cysteine-type endopeptidase activity negative regulation of inflammatory response negative regulation of lactation negative regulation of tumor necrosis factor-mediated signaling pathway regulation of blood pressure response to 11-deoxycorticosterone response to dehydroepiandrosterone response to estradiol response to heat response to progesterone
lactation protein stabilization response to 11-deoxycorticosterone response to dehydroepiandrosterone response to estradiol response to progesterone
adaptive immune response blood coagulation, common pathway blood coagulation, fibrin clot formation cell-matrix adhesion fibrinolysis induction of bacterial agglutination innate immune response negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasminogen activation platelet aggregation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis positive regulation of heterotypic cell-cell adhesion positive regulation of peptide hormone secretion positive regulation of protein secretion positive regulation of substrate adhesion-dependent cell spreading positive regulation of vasoconstriction protein polymerization protein-containing complex assembly response to calcium ion
adaptive immune response blood coagulation, common pathway fibrinolysis innate immune response negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors platelet aggregation positive regulation of ERK1 and ERK2 cascade positive regulation of heterotypic cell-cell adhesion positive regulation of peptide hormone secretion protein polymerization
platelet activation protein polymerization
adaptive immune response blood coagulation, fibrin clot formation cell-matrix adhesion cellular response to interleukin-1 cellular response to leptin stimulus fibrinolysis induction of bacterial agglutination innate immune response negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasminogen activation platelet aggregation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis positive regulation of heterotypic cell-cell adhesion positive regulation of peptide hormone secretion positive regulation of protein secretion positive regulation of substrate adhesion-dependent cell spreading positive regulation of vasoconstriction protein polymerization protein-containing complex assembly response to calcium ion
adaptive immune response blood coagulation, fibrin clot formation cell-matrix adhesion innate immune response platelet aggregation protein polymerization
blood coagulation, fibrin clot formation cell-matrix adhesion cellular response to interleukin-1 cellular response to interleukin-6 fibrinolysis negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasminogen activation platelet aggregation platelet maturation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis positive regulation of heterotypic cell-cell adhesion positive regulation of peptide hormone secretion positive regulation of protein secretion positive regulation of substrate adhesion-dependent cell spreading positive regulation of vasoconstriction protein polymerization protein secretion protein-containing complex assembly response to calcium ion
blood coagulation, fibrin clot formation cell-matrix adhesion cellular response to interleukin-1 cellular response to interleukin-6 fibrinolysis negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasminogen activation platelet aggregation platelet maturation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis positive regulation of heterotypic cell-cell adhesion positive regulation of peptide hormone secretion positive regulation of protein secretion positive regulation of vasoconstriction protein polymerization protein secretion protein-containing complex assembly response to calcium ion
amyloid precursor protein metabolic process apoptotic process clathrin coat assembly dopamine receptor signaling pathway endosomal transport neurotransmitter receptor cycle neurotransmitter receptor transport, endosome to postsynaptic membrane positive regulation of receptor recycling postsynaptic neurotransmitter receptor cycle receptor recycling regulation of long-term synaptic potentiation spontaneous synaptic transmission vesicle-mediated transport in synapse
axon ensheathment central nervous system development chemical synaptic transmission immune response maintenance of blood-brain barrier MAPK cascade membrane organization myelination negative regulation of heterotypic cell-cell adhesion positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of interleukin-6 production positive regulation of metalloendopeptidase activity response to toxic substance sensory perception of sound substantia nigra development
myelination
maintenance of blood-brain barrier MAPK cascade membrane organization myelination negative regulation of axonogenesis negative regulation of heterotypic cell-cell adhesion positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of interleukin-6 production response to fatty acid response to mercury ion response to progesterone response to toxic substance response to tumor necrosis factor sensory perception of sound
fatty acid transport membrane organization
fatty acid transport membrane organization
cellular response to hydrogen peroxide cellular response to hypoxia fatty acid transport intestinal absorption long-chain fatty acid transport negative regulation of apoptotic process positive regulation of fatty acid beta-oxidation response to vitamin B3
fatty acid metabolic process fatty acid transport intestinal absorption intestinal lipid absorption long-chain fatty acid transport
fatty acid transport lipid homeostasis regulation of granulocyte differentiation response to benzoic acid response to retinoic acid response to vitamin A retinoic acid biosynthetic process retinoic acid metabolic process retinol metabolic process vitamin A metabolic process
eye photoreceptor cell development G protein-coupled receptor signaling pathway phototransduction protein localization
absorption of visible light adaptation of rhodopsin mediated signaling cellular response to light stimulus detection of temperature stimulus involved in thermoception G protein-coupled receptor signaling pathway gene expression microtubule cytoskeleton organization photoreceptor cell maintenance phototransduction phototransduction, visible light podosome assembly response to light stimulus rhodopsin mediated signaling pathway rod bipolar cell differentiation thermotaxis visual perception
absorption of visible light rhodopsin mediated signaling pathway visual perception
antibacterial humoral response
cell adhesion folic acid transport fusion of sperm to egg plasma membrane involved in single fertilization sperm-egg recognition
cellular response to extracellular stimulus
muscle cell cellular homeostasis musculoskeletal movement neuromuscular junction development neuromuscular process neuromuscular synaptic transmission neuron cellular homeostasis neuronal action potential regulation of membrane potential response to nicotine signal transduction skeletal muscle contraction skeletal muscle tissue growth synaptic transmission, cholinergic
muscle cell cellular homeostasis neuromuscular junction development neuromuscular synaptic transmission neuron cellular homeostasis neuronal action potential response to nicotine skeletal muscle contraction skeletal muscle tissue growth synaptic transmission, cholinergic
monoatomic cation transport musculoskeletal movement regulation of membrane potential skeletal muscle contraction skeletal muscle tissue growth
adaptive thermogenesis ADP transport mitochondrial ADP transmembrane transport mitochondrial ATP transmembrane transport negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of mitophagy regulation of mitochondrial membrane permeability
bicarbonate transport blood coagulation chloride transmembrane transport chloride transport erythrocyte development intracellular monoatomic ion homeostasis monoatomic anion transport negative regulation of glycolytic process through fructose-6-phosphate negative regulation of urine volume pH elevation plasma membrane phospholipid scrambling protein localization to plasma membrane regulation of intracellular pH transmembrane transport
acute-phase response defense response to Gram-positive bacterium inflammatory response innate immune response negative regulation of lipid storage negative regulation of macrophage derived foam cell differentiation negative regulation of mononuclear cell proliferation opsonization positive regulation of gene expression positive regulation of superoxide anion generation regulation of interleukin-8 production vasoconstriction
acute-phase response chaperone-mediated protein complex assembly innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation of acute inflammatory response negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of monocyte differentiation negative regulation of viral entry into host cell negative regulation of viral process negative regulation of wound healing protein folding
astrocyte activation cell-cell signaling complement activation complement activation, classical pathway complement-mediated synapse pruning innate immune response microglial cell activation neuron remodeling synapse organization synapse pruning vertebrate eye-specific patterning
blood coagulation, intrinsic pathway negative regulation of angiogenesis negative regulation of blood coagulation negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation negative regulation of fibrinolysis negative regulation of myeloid cell apoptotic process negative regulation of smooth muscle cell apoptotic process plasminogen activation positive regulation of blood coagulation positive regulation of lipoprotein lipase activity regulation of fibrinolysis triglyceride metabolic process triglyceride transport
brown fat cell differentiation keratinocyte migration leukocyte adhesion to vascular endothelial cell positive regulation of angiogenesis positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation involved in wound healing positive regulation of epithelial to mesenchymal transition positive regulation of keratinocyte proliferation positive regulation of transforming growth factor beta receptor signaling pathway response to bacterium wound healing, spreading of epidermal cells
negative regulation of sensory perception of bitter taste negative regulation of sensory perception of sweet taste riboflavin transport
cardiac muscle tissue development embryonic organ morphogenesis embryonic retina morphogenesis in camera-type eye embryonic skeletal system development eye development female genitalia morphogenesis gluconeogenesis glucose homeostasis heart development heart trabecula formation lung development maintenance of gastrointestinal epithelium negative regulation of cardiac muscle cell proliferation positive regulation of immunoglobulin production positive regulation of insulin secretion response to retinoic acid retinol metabolic process retinol transport urinary bladder development uterus development vagina development visual perception
cell adhesion female pregnancy heme catabolic process negative regulation of immune response negative regulation of JNK cascade
aerobic respiration cellular response to lipid energy reserve metabolic process glucose homeostasis heat generation locomotor rhythm mitochondrion organization negative regulation of DNA-templated transcription negative regulation of gluconeogenesis negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of lipid biosynthetic process negative regulation of lipid storage positive regulation of gene expression positive regulation of glucose metabolic process positive regulation of lipid metabolic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
aerobic respiration cellular response to lipid energy reserve metabolic process glucose homeostasis heat generation locomotor rhythm mitochondrion organization negative regulation of DNA-templated transcription negative regulation of gluconeogenesis negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of lipid biosynthetic process negative regulation of lipid storage positive regulation of gene expression positive regulation of glucose metabolic process positive regulation of lipid metabolic process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
acute inflammatory response to antigenic stimulus acute-phase response animal organ regeneration cellular response to glucocorticoid stimulus cellular response to growth hormone stimulus cellular response to retinoic acid chronic inflammatory response to antigenic stimulus negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production regulation of immune system process response to lipopolysaccharide response to organic cyclic compound response to vitamin E response to xenobiotic stimulus
acute-phase response negative regulation of bone mineralization negative regulation of insulin receptor signaling pathway ossification pinocytosis positive regulation of phagocytosis regulation of bone mineralization regulation of inflammatory response skeletal system development
purine nucleobase metabolic process
purine nucleobase metabolic process thyroid hormone metabolic process
cellular response to calcium ion starvation cellular response to starvation negative regulation of mitochondrial depolarization
cellular response to calcium ion starvation cellular response to starvation negative regulation of mitochondrial depolarization
cellular response to calcium ion starvation cellular response to starvation negative regulation of mitochondrial depolarization positive regulation of circadian sleep/wake cycle, non-REM sleep response to mercury ion response to nutrient response to organic substance response to platinum ion vasodilation
ovulation from ovarian follicle progesterone metabolic process
ovulation from ovarian follicle progesterone metabolic process sexual reproduction
animal organ regeneration cellular response to retinoic acid liver development liver regeneration ovulation from ovarian follicle pancreas development progesterone metabolic process response to dexamethasone response to organic substance sexual reproduction
vitamin D metabolic process vitamin transport
antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide chemokine-mediated signaling pathway defense response to bacterium glucose transmembrane transport inflammatory response neutrophil chemotaxis positive regulation of cell division
adenylate cyclase-activating G protein-coupled receptor signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide chemokine-mediated signaling pathway cytokine-mediated signaling pathway defense response to protozoan inflammatory response killing by host of symbiont cells leukocyte chemotaxis negative regulation of angiogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of megakaryocyte differentiation negative regulation of MHC class II biosynthetic process neutrophil chemotaxis platelet activation positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of macrophage differentiation positive regulation of transcription by RNA polymerase II positive regulation of tumor necrosis factor production regulation of cell population proliferation
adenylate cyclase-activating G protein-coupled receptor signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide chemokine-mediated signaling pathway cytokine-mediated signaling pathway inflammatory response leukocyte chemotaxis negative regulation of angiogenesis negative regulation of megakaryocyte differentiation neutrophil chemotaxis platelet activation positive regulation of transcription by RNA polymerase II regulation of cell population proliferation
phospholipid efflux positive regulation of sperm capacitation single fertilization sperm capacitation
actin filament organization antibacterial humoral response cellular response to iron ion ERK1 and ERK2 cascade intracellular iron ion homeostasis iron ion transport osteoclast differentiation positive regulation of bone resorption positive regulation of cell motility positive regulation of DNA-templated transcription positive regulation of phosphorylation positive regulation of receptor-mediated endocytosis regulation of iron ion transport regulation of protein stability
acute-phase response antibacterial humoral response antimicrobial humoral response extracellular sequestering of iron ion intracellular sequestering of iron ion iron ion transport response to lipopolysaccharide response to xenobiotic stimulus
heme metabolic process heme transport hemoglobin metabolic process intracellular iron ion homeostasis positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of immunoglobulin production positive regulation of type II interferon-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein type II interferon-mediated signaling pathway
intracellular iron ion homeostasis intracellular sequestering of iron ion iron ion transport
immune response intracellular iron ion homeostasis intracellular sequestering of iron ion iron ion transport negative regulation of cell population proliferation negative regulation of fibroblast proliferation
cellular response to cadmium ion cellular response to copper ion cellular response to erythropoietin cellular response to interleukin-3 cellular response to zinc ion detoxification of copper ion intracellular copper ion homeostasis intracellular zinc ion homeostasis negative regulation of growth
cellular response to cadmium ion cellular response to copper ion cellular response to zinc ion detoxification of copper ion intracellular zinc ion homeostasis negative regulation of growth nitric oxide mediated signal transduction response to bacterium
cellular response to cadmium ion cellular response to chromate cellular response to copper ion cellular response to zinc ion detoxification of copper ion intracellular monoatomic cation homeostasis intracellular zinc ion homeostasis negative regulation of growth negative regulation of neuron apoptotic process nitric oxide mediated signal transduction
biomineral tissue development defense response to bacterium negative regulation of bone mineralization ossification saliva secretion