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Information Theory and the IrisCode | Iris recognition has legendary resistance to false matches, and the tools of information theory can help to explain why. The concept of entropy is fundamental to understanding biometric collision avoidance. This paper analyses the bit sequences of IrisCodes computed both from real iris images and from synthetic white noise iris images, whose pixel values are random and uncorrelated. The capacity of the IrisCode as a channel is found to be 0.566 bits per bit encoded, of which 0.469 bits of entropy per bit is encoded from natural iris images. The difference between these two rates reflects the existence of anatomical correlations within a natural iris, and the remaining gap from one full bit of entropy per bit encoded reflects the correlations in both phase and amplitude introduced by the Gabor wavelets underlying the IrisCode. A simple two-state hidden Markov model is shown to emulate exactly the statistics of bit sequences generated both from natural and white noise iris images, including their imposter distributions, and may be useful for generating large synthetic IrisCode databases. |
The effect of acupressure on nausea and vomiting after cesarean section under spinal anesthesia. | Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications. Aside from pharmacological interventions, other complementary healing modalities have been introduced to assist patients in decreasing PONV and improving postoperative outcomes. This study examined acupressure as a safe complement to the more traditional approach of using drugs to prevent and/or relieve nausea and vomiting in the Cesarean section (C/S) under spinal anesthesia. In a prospective randomized clinical trial, 152 patients who were candidate for elective C/S under spinal anesthesia were evaluated in two groups (acupressure vs control groups). Subjects in the acupressure group received constant pressure by a specific wrist elastic band (without puncture of the skin) on the Nei-Guan acupuncture point, 30 min prior to spinal anesthesia. The incidence of PONV was assessed during the surgery, at recovery room and at 1st, 2nd and 3rd two hours after the surgery. Significant differences in the incidence of the post-operative nausea and vomiting were found between the acupressure and control groups, with a reduction in the incidence rate of nausea from 35.5% to 13.2%. The amount of vomitus and the degree of discomfort were, respectively, less and lower in the study group. In view of the total absence of side-effects in acupressure, its application is worthy. Our study confirmed the effectiveness of acupressure in preventing post-operative nausea and vomiting, when applied 30 minutes prior to surgery. |
Optimal care for rheumatoid arthritis: a focus group study | Our study sought to identify barriers to optimal care for individuals with rheumatoid arthritis (RA). Our study was set in a population with universal access to comprehensive health care in the context of a university hospital health network. Using purposive sampling, we invited RA patients, health professionals, and decision makers from urban and rural regions to participate in structured focus group interviews. Content analysis was performed to determine themes emerging from the data. We identified four general themes. First, initial barriers to optimal care for people begin before primary care contact, at the level of the general population and/or related to primary care access. Second, many factors (at the patient, physician, and system level) influenced how quickly a patient is referred from primary to specialty care. Third, after referral, multiple comanagement issues influence patient outcomes. Fourth, optimizing RA care requires adequate resources. Participants emphasized the need for more education (of patients, of health care providers, and within the general community), better communication between and among patients and health care providers, and more efficient use of existing resources. Our work provides insights regarding barriers to and facilitators of optimal care in RA. Further work with these stakeholder groups in our health care region will examine potential solutions and the feasibility of their implementation. Our work provides an example of how research can assist stakeholder leaders in creating structured and incremental plans to improve health care delivery for persons with chronic diseases like RA. |
Efficacy of Texture, Shape, and Intensity Feature Fusion for Posterior-Fossa Tumor Segmentation in MRI | Our previous works suggest that fractal texture feature is useful to detect pediatric brain tumor in multimodal MRI. In this study, we systematically investigate efficacy of using several different image features such as intensity, fractal texture, and level-set shape in segmentation of posterior-fossa (PF) tumor for pediatric patients. We explore effectiveness of using four different feature selection and three different segmentation techniques, respectively, to discriminate tumor regions from normal tissue in multimodal brain MRI. We further study the selective fusion of these features for improved PF tumor segmentation. Our result suggests that Kullback-Leibler divergence measure for feature ranking and selection and the expectation maximization algorithm for feature fusion and tumor segmentation offer the best results for the patient data in this study. We show that for T1 and fluid attenuation inversion recovery (FLAIR) MRI modalities, the best PF tumor segmentation is obtained using the texture feature such as multifractional Brownian motion (mBm) while that for T2 MRI is obtained by fusing level-set shape with intensity features. In multimodality fused MRI (T1, T2, and FLAIR), mBm feature offers the best PF tumor segmentation performance. We use different similarity metrics to evaluate quality and robustness of these selected features for PF tumor segmentation in MRI for ten pediatric patients. |
MPPT performance improvement of PV system using hybrid-PI controller | This paper proposes the hybrid-PI hybrid-PI control for MPPT control of photovoltaic system. The conventional constant voltage(CV), perturbation and observation(PO) and incremental conductance(IC) are the method which finding maximum power point(MPP) by the continued self-excitation vibration, and uses the fixed step size. If the fixed step size is a large, the tracking speed of maximum power point is faster, but the tracking accuracy in the steady state is decreased. On the contrary, when the fixed step size is a small, the tracking accuracy is increased and the tracking speed is slower. Therefore, in order to solve these problems, this paper proposes hybrid-PI controller that is adjusted gain of conventional PI control using fuzzy control, and the maximum power point tracks using this controller. The validity of the controller proposed in this paper proves through the results of the comparisons. |
Monotonic Calibrated Interpolated Look-Up Tables | Real-world machine learning applications may require functions to be fast-to-evaluate and interpretable, in particular, guaranteed monotonicity of the learned function can be critical to user trust. We propose meeting these goals for low-dimensional machine learning problems by learning flexible, monotonic functions using calibrated interpolated look-up tables. We extend the structural risk minimization framework of lattice regression to train monotonic functions by solving a convex problem with appropriate linear inequality constraints. In addition, we propose jointly learning interpretable calibrations of each feature to normalize continuous features and handle categorical or missing data, at the cost of making the objective non-convex. We address large-scale learning through parallelization, mini-batching, and propose random sampling of additive regularizer terms. Case studies for six real-world problems with five to sixteen features and thousands to millions of training samples demonstrate the proposed monotonic functions can achieve state-of-the-art accuracy on practical problems while providing greater transparency to users. |
Emergence of a classical Universe from quantum gravity and cosmology. | I describe how we can understand the classical appearance of our world from a universal quantum theory. The essential ingredient is the process of decoherence. I start with a general discussion in ordinary quantum theory and then turn to quantum gravity and quantum cosmology. There is a whole hierarchy of classicality from the global gravitational field to the fluctuations in the cosmic microwave background, which serve as the seeds for the structure in the Universe. |
Urban area characterization based on crowd behavioral lifelogs over Twitter | Recent location-based social networking sites are attractively providing us with a novel capability of monitoring massive crowd lifelogs in the real-world space. In particular, they make it easier to collect publicly shared crowd lifelogs in a large scale of geographic area reflecting the crowd’s daily lives and even more characterizing urban space through what they have in minds and how they behave in the space. In this paper, we challenge to analyze urban characteristics in terms of crowd behavior by utilizing crowd lifelogs in urban area over the social networking sites. In order to collect crowd behavioral data, we exploit the most famous microblogging site, Twitter, where a great deal of geo-tagged micro lifelogs emitted by massive crowds can be easily acquired. We first present a model to deal with crowds’ behavioral logs on the social network sites as a representing feature of urban space’s characteristics, which will be used to conduct crowd-based urban characterization. Based on this crowd behavioral feature, we will extract significant crowd behavioral patterns in a period of time. In the experiment, we conducted the urban characterization by extracting the crowd behavioral patterns and examined the relation between the regions of common crowd activity patterns and the major categories of local facilities. |
Dosing accuracy of artesunate and amodiaquine as treatment for falciparum malaria in Casamance, Senegal. | OBJECTIVES
Several products of artesunate plus amodiaquine (AS + AQ) are being deployed in malaria-endemic countries for treating uncomplicated falciparum malaria but dosing accuracy and consequential effects on efficacy and tolerability have not been examined.
METHODS
Patients with parasitologically confirmed, uncomplicated falciparum malaria were treated and followed by research teams or local health centre staff in Casamance, Senegal. AS + AQ was given as: (i) loose combination (AS 50 mg, AQ 200 mg), dosed on body weight, or (ii) co-blistered product (AS 50 mg, AQ 153 mg) dosed by weight or age. Target doses were: (i) AS 4 (2-10) mg/kg/day and (ii) AQ 10 (7.5-15) mg/kg/day. Patients receiving therapeutic doses defined dosing accuracy. Treatment-emergent signs and symptoms (TESS) were recorded.
RESULTS
A total of 3277 patients were treated with loose (n = 1972, weight-dosed) or co-blistered (n = 1305, 962 age-dosed, 343 weight-dosed) AS + AQ by the research team (n = 966) or clinic staff (n = 2311). AS was dosed correctly in >99% with all regimens. Loose AQ by weight was 98% correct. The co-blister AQ overdosed 18% of patients when dosed by age and underdosed 13% by weight. Low weight was an independent risk factor for overdosing. The co-blister had significantly more TESS than the loose product [117/1305 (9%) vs. 41/1972 (2%), relative risk = 4.3 (95% CI: 3.0-6.1, P < 0.0001)]. Age-based dosing accounted for the difference. TESS occurred mostly within one day (72%) and were mild or moderate (75%).
CONCLUSION
Artesunate is easier to dose than AQ. Currently available age-dosed, co-blistered AS + AQ tends to overdose AQ and is less well tolerated than loose tablets. It is not the optimal presentation of AS + AQ. |
Dual Grid Array Antennas in a Thin-Profile Package for Flip-Chip Interconnection to Highly Integrated 60-GHz Radios | We examine the current development of highly integrated 60-GHz radios with an interest in antenna-circuit interfaces. We design and analyze grid array antennas with special attention to the differential feeding and the patterned ground plane. More importantly, we integrate two grid array antennas in a package; propose the way of assembling it to the system printed circuit board; and demonstrate a total solution of low cost and thin profile to highly integrated 60-GHz radios. We show that the package in low temperature cofired ceramic (LTCC) technology measures only 13×13×0.575 mm3 ; can carry a 60-GHz radio die of current and future sizes with flip-chip bonding; and achieves good antenna performance in the 60-GHz band with maximum gain of 13.5 and 14.5 dBi for the single-ended and differential antennas, respectively. |
The Switch-Mode Flying-Capacitor DC–DC Converters With Improved Natural Balancing | This paper presents investigations of voltage-sharing stabilization with the use of passive RLC circuit in switch-mode flying capacitor DC-DC converters. Practical and simulation results and also a mathematical analysis of the balancing process in boost and buck-boost converters are presented. Analyzed converters use additional capacitors (flying capacitors), charged to proper value, for decreasing the voltage on switches and increasing the inductor-current frequency. Such advantages are achieved under proper voltage sharing on the flying capacitors. The voltages are stabilized in a natural way by the load current and with the use of external RLC circuit to force the current that flows through the converters' capacitors under unbalance state. This paper focuses on the analysis of the balancing phenomenon with the use of the external RLC circuit in these topologies. The balancing booster improves the balancing process in these converters, making it independent of the load. It can also reduce oscillations that arise in the converters in transient states. |
Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes | Heart rate variability (HRV), a measure of autonomic function, can predict survival outcomes. Cardiovascular disease is a known complication of diabetes, and we aimed to determine if autonomic dysfunction was associated with carotid artery atherosclerotic plaques in type 2 diabetic patients. We assessed frequency domain HRV from power spectral analysis of 24 h Holter ECG recordings, expiration/inspiration (E/I) ratio during deep breathing, acceleration index (AI) of R–R interval in response to head-up tilt, and the degree of carotid artery atherosclerosis in 61 type-2 diabetic patients (39 males, 45–69 years). Studies were carried out 5–6 years after diagnosis (baseline) and repeated 8 years after diagnosis (follow-up). At baseline, patients diagnosed with autonomic neuropathy, with abnormal E/I ratio and abnormal AI measurements, had decreased low frequency (LF) HRV. Baseline E/I ratio correlated with day (r = 0.34; P < 0.001) and night-time (r = 0.44; P < 0.001) LF power. Night-time HRV did not differ in patient with and without autonomic neuropathy. Reduced common carotid artery diameter and atherosclerotic intima-media thickness (IMT) both correlated with HRV at baseline. At follow-up, all HRV variables decreased significantly. Furthermore, patients with lower LF power at baseline, had a larger increase in the thickness of the carotid bulb intima-media at follow-up. Our results show that LF HRV power is associated with the extent and progression of carotid atherosclerosis in type 2 diabetes. A low LF HRV may predict the progression of atherosclerosis in these patients. |
Automatic Domain Adaptation for Parsing | Current statistical parsers tend to perform well only on their training domain and nearby genres. While strong performance on a few related domains is sufficient for many situations, it is advantageous for parsers to be able to generalize to a wide variety of domains. When parsing document collections involving heterogeneous domains (e.g. the web), the optimal parsing model for each document is typically not obvious. We study this problem as a new task —multiple source parser adaptation. Our system trains on corpora from many different domains. It learns not only statistics of those domains but quantitative measures of domain differences and how those differences affect parsing accuracy. Given a specific target text, the resulting system proposes linear combinations of parsing models trained on the source corpora. Tested across six domains, our system outperforms all non-oracle baselines including the best domain-independent parsing model. Thus, we are able to demonstrate the value of customizing parsing models to specific domains. |
The Streaming Capacity of Sparsely Connected P2P Systems With Distributed Control | Peer-to-peer (P2P) streaming technologies can take advantage of the upload capacity of clients, and hence can scale to large content distribution networks with lower cost. A fundamental question for P2P streaming systems is the maximum streaming rate that all users can sustain. Prior works have studied the optimal streaming rate for a complete network, where every peer is assumed to be able to communicate with all other peers. This is, however, an impractical assumption in real systems. In this paper, we are interested in the achievable streaming rate when each peer can only connect to a small number of neighbors. We show that even with a random peer-selection algorithm and uniform rate allocation, as long as each peer maintains Ω(lon N) downstream neighbors, where N is the total number of peers in the system, the system can asymptotically achieve a streaming rate that is close to the optimal streaming rate of a complete network. These results reveal a number of important insights into the dynamics of the system, based on which we then design simple improved algorithms that can reduce the constant factor in front of the Ω(lon N) term, yet can achieve the same level of performance guarantee. Simulation results are provided to verify our analysis. |
Alcohol Use, Misuse, and Abuse Among Nursing Students: A Photovoice Study. | BACKGROUND
Rates and frequencies of alcohol consumption remain unknown among nursing students, and risk and protective factors associated with alcohol misuse are poorly understood. Nursing curricula often lack content on substance use disorders among nurses, which is reported to begin prior to or during college.
PURPOSE
The aims of the study were to examine nursing students' perceptions of the risk and protective factors associated with alcohol behaviors among themselves and their peers and to identify substance use policies and their influence.
METHODS
We used the Photovoice method, which employs participatory action research. Participants were screened for alcohol misuse via AUDIT-C, and thoughts and perceptions were obtained regarding their alcohol consumption behaviors through self-expression and group advocacy. Data were collected from four focus groups that included nine undergraduate nursing students.
RESULTS
Data reflected the following key issues: stress, environmental influences, societal acceptance, and availability of alcohol. Participants identified that the following problems place them at risk for alcohol misuse: lack of addiction/alcohol education; nursing program expectations increase stress/anxiety; unhealthy habits, social isolation, and individual influences; peer influence/the college experience; and ineffective and unenforced campus policies. Protective factors included university policies; life experiences; and nursing program policies, responsibilities, peer influences, and perceived reputation.
CONCLUSION
This action research informed a dialogue with colleagues regarding nursing students' stressors and resulting professional ramifications. Recommendations for future work include investigation of expressed social isolation from university peers and its effects on their alcohol consumption behaviors and increase alcohol education with emphasis on adaptive coping strategies in a stressful professional role in Bachelor of Science in Nursing curricula. |
A Framework for the Classi fi cation of Joint Hypermobility and Related Conditions | 2017 Wil In the last decade, growing attention has been placed on joint hypermobility and related disorders. The new nosology for Ehlers–Danlos syndrome (EDS), the best-known and probably the most common of the disorders featuring joint hypermobility, identifies more than 20 different types of EDS, and highlights the need for a single set of criteria to substitute the previous ones for the overlapping EDS hypermobility type and joint hypermobility syndrome. Joint hypermobility is a feature commonly encountered in many other disorders, both genetic and acquired, and this finding is attracting the attention of an increasing number of medical and non-medical disciplines. In this paper, the terminology of joint hypermobility and related disorders is summarized. Different types of joint hypermobility, its secondary musculoskeletal manifestations and a simplified categorization of genetic syndromes featuring joint hypermobility are presented. The concept of a spectrum of pathogenetically related manifestations of joint hypermobility intersecting the categories of pleiotropic syndromes with joint hypermobility is introduced. A group of hypermobility spectrum disorders is proposed as diagnostic labels for patients with symptomatic joint hypermobility but not corresponding to any other syndromes with joint hypermobility. © 2017 Wiley Periodicals, Inc. |
Fraud Risk Modelling: Requirements Elicitation in the Case of Telecom Services | Telecom providers are losing tremendous amounts of money due to fraud risks posed to Telecom services and products. Currently, they are mainly focusing on fraud detection approaches to reduce the impact of fraud risks against their services. However, fraud prevention approaches should also be investigated in order to further reduce fraud risks and improve the revenue of Telecom providers. Fraud risk modelling is a fraud prevention approach aims at identifying the potential fraud risks, estimating the damage and setting up preventive mechanisms before the fraud risks lead to actual losses. In this paper, we highlight the important requirements for a usable and context-aware fraud risk modelling approach for Telecom services. To do so, we have conducted two workshops with experts from a Telecom provider and experts from multidisciplinary areas. In order to show and document the requirements, we present two exemplary Telecom fraud scenarios, analyse and estimate the impacts of fraud risks qualitatively. |
Modeling the cost of influenza: the impact of missing costs of unreported complications and sick leave | BACKGROUND
Estimating the economic impact of influenza is complicated because the disease may have non-specific symptoms, and many patients with influenza are registered with other diagnoses. Furthermore, in some countries like Norway, employees can be on paid sick leave for a specified number of days without a doctor's certificate ("self-reported sick leave") and these sick leaves are not registered. Both problems result in gaps in the existing literature: costs associated with influenza-related illness and self-reported sick leave are rarely included. The aim of this study was to improve estimates of total influenza-related health-care costs and productivity losses by estimating these missing costs.
METHODS
Using Norwegian data, the weekly numbers of influenza-attributable hospital admissions and certified sick leaves registered with other diagnoses were estimated from influenza-like illness surveillance data using quasi-Poisson regression. The number of self-reported sick leaves was estimated using a Monte-Carlo simulation model of illness recovery curves based on the number of certified sick leaves. A probabilistic sensitivity analysis was conducted on the economic outcomes.
RESULTS
During the 1998/99 through 2005/06 influenza seasons, the models estimated an annual average of 2700 excess influenza-associated hospitalizations in Norway, of which 16% were registered as influenza, 51% as pneumonia and 33% were registered with other diagnoses. The direct cost of seasonal influenza totaled US$22 million annually, including costs of pharmaceuticals and outpatient services. The annual average number of working days lost was predicted at 793 000, resulting in an estimated productivity loss of US$231 million. Self-reported sick leave accounted for approximately one-third of the total indirect cost. During a pandemic, the total cost could rise to over US$800 million.
CONCLUSIONS
Influenza places a considerable burden on patients and society with indirect costs greatly exceeding direct costs. The cost of influenza-attributable complications and the cost of self-reported sick leave represent a considerable part of the economic burden of influenza. |
Fixed drug eruption at sites of ear piercing. | etretinate to PUVA was associated with better treatment response. In our patients with psoriasis, topical PUVA achieved improvement rates comparable with oral PUVA, with a mean cumulative UVA dose of 187.5 J ⁄ cm. Our study contradicts previous observations made in other studies on vitiligo and demonstrates that topical PUVA does have a limited therapeutic effect in vitiligo. Oral and topical PUVA showed low but equal efficacy in patients with vitiligo with a similar mean number of treatments to completion. Approximately one-quarter of our patients with vitiligo had discontinued PUVA therapy, which probably affected the outcome. It has been shown that at least 1 year of continuous and regular therapy with oral PUVA is needed to achieve a sufficient degree of repigmentation. Shorter periods were not found to be sufficient to observe clinical signs of repigmentation. Currently it is not known if the same holds true for topical PUVA. In conclusion, our results show that the efficacy of topical PUVA is comparable with that of oral PUVA, and favoured topical PUVA treatment especially in the eczema group with respect to cumulative UVA doses and success rates. Given the necessity for long-term treatment with local PUVA therapies, successful management requires maintenance of full patient compliance. Because of this, the results in this study should not only be attributed to the therapies. Because of its safety and the simplicity, topical PUVA should be considered as an alternative therapy to other phototherapy methods. |
Semantic memory and the brain: structure and processes | Recent functional brain imaging studies suggest that object concepts may be represented, in part, by distributed networks of discrete cortical regions that parallel the organization of sensory and motor systems. In addition, different regions of the left lateral prefrontal cortex, and perhaps anterior temporal cortex, may have distinct roles in retrieving, maintaining and selecting semantic information. |
A Distributed Cyber-security Framework for Heterogeneous Environments | Evolving business models, computing paradigms, and management practices are rapidly re-shaping the usage models of ICT infrastructures, and demanding for more flexibility and dynamicity in enterprise security, beyond the traditional “security perimeter” approach. Since valuable ICT assets cannot be easily enclosed within a trusted physical sandbox any more, there is an increasing need for a new generation of pervasive and capillary cybersecurity paradigms over distributed and geographically-scattered systems. Following the generalized trend towards virtualization, automation, software-definition, and hardware/software disaggregation, in this paper we elaborate on a multi-tier architecture made of a common, programmable, and pervasive data-plane and a powerful set of multi-vendor detection and analysis algorithms. Our approach leverages the growing level of programmability of ICT infrastructures to create a common and unified framework that could be used to monitor and protect distributed heterogeneous environments, including legacy enterprise networks, IoT installations, and virtual resources deployed in the cloud. |
Supporting the requirement analysis phase for the development of serious games for children | In this paper, we argue that before defining the scenario of a serious game, a thorough preparation, i.e., requirement analysis phase is needed. Before an attractive scenario can be defined, one should decide and clarify a lot of different issues that could influence the setup of the serious game, aswell as the scenario(s). This can be done in plenary sessions with the different stakeholders, but experience has shown that some guidance is needed to have focused and effective sessions, as the stakeholders are usually from different disciplines and have different backgrounds and expertise. To support this phase, we developed a tablet (iPad) app usable by non-computing, as well as computing people. We discuss the tool, as well as the way it supports the users in the requirement analysis phase for the development of serious games for children. © 2014 Elsevier B.V. All rights reserved. |
Assessing the effects of service quality and justice on customer satisfaction and the continuance intention of mobile value-added services: An empirical test of a multidimensional model | a r t i c l e i n f o Understanding the antecedents and consequences of customer satisfaction in the mobile communications market is important. This study explores the effects of service quality and justice on customer satisfaction, which, in turn, affects continuance intention of mobile services. Service quality, justice and customer satisfaction were measured by multiple dimensions. A research model was developed based on this multidimen-sional approach and was empirically examined with data collected from about one thousand users of mobile value-added services in China. Results show that all three dimensions of service quality (interaction quality, environment quality and outcome quality) have significant and positive effects on cumulative satisfaction while only one dimension of service quality (interaction quality) has a significant and positive effect on transaction-specific satisfaction. Besides procedural justice, the other two dimensions of justice (distribu-tive justice and interactional justice) significantly influence both transaction-specific satisfaction and cumulative satisfaction. Furthermore, both types of customer satisfaction have significant and positive effects on continuance intention. Implications for research and practice are discussed. With the rapid advancements of mobile network technologies, provision of various kinds of value-added services by mobile service providers is on the rise around the world. As the market becomes more and more mature, value-added services become more homogeneous and the competition for acquiring new customers and retaining existing customers becomes more intense. In this environment, customer satisfaction is a critical factor for mobile service providers to maintain or improve their market share and profitability. Prior studies have found that customer satisfaction contributes to a firm's profitability and customer retention [33,35]. In a reorganization of the communications industry in China between 2008 and 2009, the original six mobile network operators were reduced to three. Meanwhile, the availability of third-generation telecommunications technologies suggested that more mobile value-added services would be provided to the customers. A recent value-added services survey report on mobile communications conducted by Analysys in 2010 predicted that, the competition among existing mobile network operators would become fierce after the reorganization of the industry and the introduction of third-generation services. Thus, for these mobile network operators, in order to retain customers, enhancing customer satisfaction is an urgent task to tackle with. Moreover, as new mobile value-added services are released, service providers need to focus on if these new services appeal to customers and on the willingness of customers to continue to use the services. Therefore, understanding the … |
Understanding Graph-Based Trust Evaluation in Online Social Networks: Methodologies and Challenges | Online Social Networks (OSNs) are becoming a popular method of meeting people and keeping in touch with friends. OSNs resort to trust evaluation models and algorithms to improve service quality and enhance user experiences. Much research has been done to evaluate trust and predict the trustworthiness of a target, usually from the view of a source. Graph-based approaches make up a major portion of the existing works, in which the trust value is calculated through a trusted graph (or trusted network, web of trust, or multiple trust chains). In this article, we focus on graph-based trust evaluation models in OSNs, particularly in the computer science literature. We first summarize the features of OSNs and the properties of trust. Then we comparatively review two categories of graph-simplification-based and graph-analogy-based approaches and discuss their individual problems and challenges. We also analyze the common challenges of all graph-based models. To provide an integrated view of trust evaluation, we conduct a brief review of its pre- and postprocesses (i.e., the preparation and validation of trust models, including information collection, performance evaluation, and related applications). Finally, we identify some open challenges that all trust models are facing. |
From image descriptions to visual denotations: New similarity metrics for semantic inference over event descriptions | We propose to use the visual denotations of linguistic expressions (i.e. the set of images they describe) to define novel denotational similarity metrics, which we show to be at least as beneficial as distributional similarities for two tasks that require semantic inference. To compute these denotational similarities, we construct a denotation graph, i.e. a subsumption hierarchy over constituents and their denotations, based on a large corpus of 30K images and 150K descriptive captions. |
Prospective, randomized, double-blinded, double-dummy and multicenter phase IV clinical study comparing the efficacy and safety of PG201 (Layla) and SKI306X in patients with osteoarthritis. | ETHNOPHARMACOLOGICAL RELEVANCE
This prospective, randomized, double-blinded, double-dummy, multicenter study compared the efficacy and safety of PG201 (Layla®), a new product from extracts of 12 plant sources and SKI306X (Joins®) which have been well investigated and in relatively wide usage among herbal medicine, for the treatment of patients with knee osteoarthritis.
AIM OF THE STUDY
To compare the efficacy and safety of PG201 and SKI306X in patients with knee osteoarthritis.
MATERIALS AND METHODS
A prospective, double-blinded multicenter study was conducted in 124 patients with Kellgren and Lawrence grade 2-3 knee osteoarthritis. Patients were randomly assigned to receive 600mg of PG201 (300mg, twice daily) and 600mg of SKI306X placebo (200mg, thrice daily) or 600mg of SKI306X (200mg, thrice daily) and PG201 placebo (300mg, twice daily) for 12 weeks. The primary outcome was the improvement of pain by week 8 as assessed by the 100-mm pain visual analog scale (VAS). Secondary outcomes included pain VAS improvement level at week 12, pain VAS improvement rate at weeks 8 and 12, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) improvement level at weeks 8 and 12, the improvement of the quality of life (EQ-5D), overall symptom self-assessment score, and rescue medication consumption.
RESULTS
The pain VAS improvement at 8 weeks was 14.2±16.2 in the experimental group and 11.9±13.1 in control group (p=0.557), confirming that the experimental group was not inferior to the control group as lower limit (-8.38) of 95% CI of the difference of VAS improvement between two groups was well above the allowed limit (-10 mm). There was no significant difference in all secondary outcomes including pain VAS, WOMAC, EQ-5D, overall symptom self-assessment score, and rescue medication consumption. Adverse events were low and similar between the two groups.
CONCLUSIONS
The results of this study showed that PG201 significantly reduced knee pain and improved knee function and were comparable to SKI306X. PG201 can be suggested as an effective treatment of knee osteoarthritis. Trial registration ClinicalTrials.gov:NCT01768468. |
Probiotics for human health –new innovations and emerging trends | The role of the gut microbiome in human health and disease with a particular emphasis on therapeutic use of probiotics under specific medical conditions was mainly highlighted in 1st Annual conference of Probiotic Association of India (PAi) and International Symposium on "Probiotics for Human Health - New Innovations and Emerging Trends" held on 27th-28th August, 2012 at New Delhi, India. There is increasing recognition of the fact that dysbiosis or alteration of this gut microbiome may be implicated in gastro-intestinal disorders including diarrheal diseases, ulcerative colitis, inflammatory bowel diseases, life style diseases viz. Diabetes Mellitus-2 and obesity etc. This report summarizes the proceedings of the conference and the symposium comprehensively. Although, research on probiotics has been continuing for the past few decades, the subject has been currently the major focus of attention across the world due to recent advances and new developments in genomics, transcriptomics, proteomics, metabolomics and emergence of new generation of high through put sequencing technologies that have immensely helped in understanding the probiotic functionality and mode of action from nutritional and health perspectives. There is now sufficient evidence backed up with good quality scientific clinical data to suggest that probiotic interventions could indeed be effective in various types of diarrheal diseases, other chronic gastrointestinal inflammatory disorders like pouchitis, necrotizing entero-colitis, allergic responses and lactose intolerance etc. This report makes a modest attempt to give all the stake holders involved in development of probiotic based functional/health foods an overview of the current status of probiotics research at the Global and National level. The most crucial issues that emerged from the lead talks delivered by the eminent speakers from India and abroad were the major focus of discussions in different plenary and technical sessions. By discussing some of these issues from scientific perspectives, the conference could achieve its prime objective of disseminating the current knowledge on the prospects of probiotics as potential biotherapeutics in the management of human health and diseases. |
StimDust: A 6.5mm3, wireless ultrasonic peripheral nerve stimulator with 82% peak chip efficiency | We present a 6.5mm3, 10mg, wireless peripheral nerve stimulator. The stimulator is powered and controlled through ultrasound from an external transducer and utilizes a single 750×750×750μm3 piezocrystal for downlink communication, powering, and readout, reducing implant volume and mass. An IC with 0.06mm2 active circuit area, designed in TSMC 65nm LPCMOS process, converts harvested ultrasound to stimulation charge with a peak efficiency of 82%. A custom wireless protocol that does not require a clock or memory circuits reduces on-chip power to 4μW when not stimulating. The encapsulated stimulator was cuffed to the sciatic nerve of an anesthetized rodent and demonstrated full-scale nerve activation in vivo. We achieve a highly efficient and temporally precise wireless peripheral nerve stimulator that is the smallest and lightest to our knowledge. |
Security Ontologies: Improving Quantitative Risk Analysis | IT-security has become a much diversified field and small and medium sized enterprises (SMEs), in particular, do not have the financial ability to implement a holistic IT-security approach. We thus propose a security ontology, to provide a solid base for an applicable and holistic IT-security approach for SMEs, enabling low-cost risk management and threat analysis. Based on the taxonomy of computer security and dependability by Landwehr, a heavy-weight ontology can be used to organize and systematically structure knowledge on threats, safeguards, and assets. Using this ontology, each threat scenario can be simulated with a different protection profile as to evaluate the effectiveness and the cost/benefit ratio of individual safeguards |
Fire severity and seed source influence lodgepole pine (Pinus contorta var. murrayana) regeneration in the southern cascades, Lassen volcanic National Park, California | Rocky Mountain lodgepole pine, (Pinus contorta var. latifolia) regenerates quickly after high severity fire because seeds from serotinous cones are released immediately post-fire. Sierra lodgepole pine (P. contorta var. murrayana) forests burn with variable intensity resulting in different levels of severity and because this variety of lodgepole pine does not have serotinous cones, little is known about what factors influence post-fire regeneration. This study quantifies tree regeneration in a low, moderate, and high severity burn patch in a Sierra lodgepole forest 24 years after fire. Regeneration was measured in ten plots in each severity type. In each plot, we quantified pre- and post-fire forest structure (basal area, density), counted and aged tree seedlings and saplings of all species, and measured distance to the nearest seed bearing tree. There was no difference in the density of seedlings and saplings among severity classes. Distance and direction to the nearest seed bearing lodgepole pine were the best predictors of lodgepole seedling and sapling density in high severity plots. In contrast to Rocky Mountain lodgepole pine, regeneration of Sierra lodgepole pine appears to rely on in-seeding from surviving trees in low or moderate severity burn patches or live trees next to high severity burn patches. Our data demonstrate that Sierra lodgepole pine follows stand development pathways hypothesized for non-serotinous stands of Rocky Mountain lodgepole pine. |
Changes in teacher-student relationships. | BACKGROUND
Although teacher-student relationships lie at the heart of students' schooling experience, fundamental questions regarding these relationships remain unanswered.
AIMS
This study investigates three related questions about these relationships: To what extent do they change from the beginning to the end of a school year? Are any emergent changes associated with shifts in students' academic or motivational outcomes? Are certain 'upstream' factors associated with improvements or declines in teacher-student relationships?
SAMPLE
We investigate these questions with a sample of middle school students (N = 119) and their teachers (N = 30). METHODS. Through a novel approach which accounts for both perspectives within teacher-student relationships, we assess these relationships at the beginning and end of the school year. Using multi-level models, we examine how changes in these relationships are associated with changes in students' grades, homework completion rates, self-efficacy, and effort. In addition, we examine associations with two potential precursors to teacher-student relationships: students' accuracy in taking their teachers' perspective and their perceptions of similarity to their teachers.
RESULTS
We find that substantial changes occur in these relationships from the beginning to the end of the year; these changes are associated with shifts in important student outcomes; and changes in students' social perspective taking accuracy and perceived similarity to their teachers correspond with changes in teacher-student relationships.
CONCLUSIONS
Given the malleability of teacher-student relationships and their importance for key achievement and motivational outcomes, we advocate for researchers to conduct field experiments to inform how to improve these critical relationships. |
Secondary Peak Detection of PPG Signal for Continuous Cuffless Arterial Blood Pressure Measurement | The arterial blood pressure (ABP) is one of the most important physiological parameters for health monitoring. Most of the blood measurement devices in the market determine the ABP through the inflation and the deflation of a cuff controlled by a bladder. This method is very uncomfortable for most of the users and may even cause anxiety, which in turn can affect the blood pressure (BP) (white coat syndrome). This paper investigates a cuffless nonintrusive approach to estimate the BP. The main idea is to measure the pulse transit time (PTT), i.e., the delay between the R-peak of the electrocardiogram (ECG) signal and the following peak of the finger photoplethysmograph (PPG) signal. The main problem of this approach is that when the dicrotic notch of the PPG signal is unobservable, the position and the amplitude of the main peak of the PPG signal will be changed. As a result, the correlation between the BP and the PTT can be affected. To overcome this problem, three types of secondary peak detection methods are designed to reveal the secondary peak from the original PPG signal. Actual ECG, PPG, and the BP measurements extracted from the Multiparameter Intelligent Monitoring in Intensive Care II database that contains clinical signal data reflecting real measurements are used. The results verify that the proposed detection methods improve the correlation relationship between the BP and the PTT, and demonstrate that the adjusted PTT can be used as an indicator of the ABP by removing the dicrotic notch impact on the PPG signal. |
Low-energy gluon to the vacuum polarization of heavy quarks | We calculate a correction to the effective electromagnetic current at low energies, induced by a heavy-quark loop, and determine the analytic structure of the vacuum polarization function at small q2, for which an explicit expression is given to the O(αs3) order of perturbation theory. Implications to the high-precision analysis of experimental data on heavy-quark production in e+e− annihilation are discussed. |
A Novel Compact Ultra-Wideband (UWB) Wide Slot Antenna with via Holes | Abstract—A novel compact ultra-wideband (UWB) wide slot antenna with via holes is presented for UWB applications. The antenna is composed of a trapezoidal slot on the ground plane, a rectangular patch in the center of the slot and three via holes connecting the rectangular patch and the microstrip feed-line. The antenna is successfully designed, implemented, and measured. The measured results show that the proposed antenna with compact size of 27.0mm×29.0 mm×1.0mm achieves good performance, such as an impedance matching bandwidth of 111.7% (|S11| ≤ −10 dB), constant gain and stable radiation patterns over its whole frequency range. |
RESEARCH ARTICLE Questions of quality in repositories of open educational resources: a literature review | Open educational resources (OER) are teaching and learning materials which are freely available and openly licensed. Repositories of OER (ROER) are platforms that host and facilitate access to these resources. ROER should not just be designed to store this content ! in keeping with the aims of the OER movement, they should support educators in embracing open educational practices (OEP) such as searching for and retrieving content that they will reuse, adapt or modify as needed, without economic barriers or copyright restrictions. This paper reviews key literature on OER and ROER, in order to understand the roles ROER are said or supposed to fulfil in relation to furthering the aims of the OER movement. Four themes which should shape repository design are identified, and the following 10 quality indicators (QI) for ROER effectiveness are discussed: featured resources; user evaluation tools; peer review; authorship of the resources; keywords of the resources; use of standardised metadata; multilingualism of the repositories; inclusion of social media tools; specification of the creative commons license; availability of the source code or original files. These QI form the basis of a method for the evaluation of ROER initiatives which, in concert with considerations of achievability and long-term sustainability, should assist in enhancement and development. |
Biquad Filter Using the Current Feedback Operational Amplifier | A new MOS-C bandpass-low-pass filter using the current feedback operational amplifier (CFOA) is presented. The filter employs two CFOA’s, eight MOS transistors operating in the nonsaturation region, and two grounded capacitors. The proposed MOS-C filter has the advantage of independent control ofQ and !o. PSpice simulation results for the proposed filter are given. |
Cloud Computing Security: What Changes with Software-Defined Networking? | Broadly construed, Software-Defined Networking (SDN) refers to the use of a standards-based open architecture and its supporting open source and open interfaces technologies to enable the deployment, management, and operation of networks. While traditional network management relies on vendor-specific hardware, protocols, and software, SDN systems are architected to have well-defined control and data planes offering flexible management interfaces. The enhanced control enabled by SDN opens opportunities for better cloud security engineering. At the same time, new vulnerabilities are potentially exposed as new technologies are introduced. This chapter discusses how SDN impacts cloud security, and potential risks that need to be addressed when SDN is deployed within and across clouds. |
Collaboratively crowdsourcing workflows with turkomatic | Preparing complex jobs for crowdsourcing marketplaces requires careful attention to workflow design, the process of decomposing jobs into multiple tasks, which are solved by multiple workers. Can the crowd help design such workflows? This paper presents Turkomatic, a tool that recruits crowd workers to aid requesters in planning and solving complex jobs. While workers decompose and solve tasks, requesters can view the status of worker-designed workflows in real time; intervene to change tasks and solutions; and request new solutions to subtasks from the crowd. These features lower the threshold for crowd employers to request complex work. During two evaluations, we found that allowing the crowd to plan without requester supervision is partially successful, but that requester intervention during workflow planning and execution improves quality substantially. We argue that Turkomatic's collaborative approach can be more successful than the conventional workflow design process and discuss implications for the design of collaborative crowd planning systems. |
CMOS Low Noise Amplifier with Capacitive Feedback Matching | A capacitive shunt feedback LNA input matching network is demonstrated which offers matching, good noise performance, low component count and low area consumption. A prototype 9 GHz LNA vehicle amplifier is designed and fabricated in a 130 nm RF-CMOS process. The measured amplifier has 20.5 dB of gain at 8.8 GHz with input and output match of -15 dB and -8 dB respectively. It has 1.4 GHz of 3 dB-bandwidth around 9 GHz with the noise figure of 1.7 dB at the center frequency and below 2 dB across the band. Large signal measurements reveal that the amplifier can deliver -2 dBm of power to the 50Omega output load at its 1 dB compression point. It draws 23 mA of current from a 1.2 V supply. The chip occupies an area of 0.64 mm2. |
A Naturalistic Open Source Movie for Optical Flow Evaluation | Ground truth optical flow is difficult to measure in real scenes with natural motion. As a result, optical flow data sets are restricted in terms of size, complexity, and diversity, making optical flow algorithms difficult to train and test on realistic data. We introduce a new optical flow data set derived from the open source 3D animated short film Sintel. This data set has important features not present in the popular Middlebury flow evaluation: long sequences, large motions, specular reflections, motion blur, defocus blur, and atmospheric effects. Because the graphics data that generated the movie is open source, we are able to render scenes under conditions of varying complexity to evaluate where existing flow algorithms fail. We evaluate several recent optical flow algorithms and find that current highly-ranked methods on the Middlebury evaluation have difficulty with this more complex data set suggesting further research on optical flow estimation is needed. To validate the use of synthetic data, we compare the imageand flow-statistics of Sintel to those of real films and videos and show that they are similar. The data set, metrics, and evaluation website are publicly available. |
3D Wire mesh photonic crystals. | We have investigated the electromagnetic properties of a 3D wire mesh in a geometry rese covalently bonded diamond. The frequency and wave vector dispersion show forbidden bands a frequenciesn0, corresponding to the lattice spacing, just as dielectric photonic crystals do. But have a new forbidden band which commences at zero frequency and extends, in our geome , 12 n0, acting as a type of plasma cutoff frequency. Wire mesh photonic crystals appear to sup longitudinal plane wave, as well as two transverse plane waves. We identify an important new r for microwave photonic crystals, an effective medium limit, in which electromagnetic waves pene deeply into the wire mesh through the aid of an impurity band. |
Enhanced Operating System Security Through Efficient and Fine-grained Address Space Randomization | In recent years, the deployment of many applicationlevel countermeasures against memory errors and the increasing number of vulnerabilities discovered in the kernel has fostered a renewed interest in kernel-level exploitation. Unfortunately, no comprehensive and wellestablished mechanism exists to protect the operating system from arbitrary attacks, due to the relatively new development of the area and the challenges involved. In this paper, we propose the first design for finegrained address space randomization (ASR) inside the operating system (OS), providing an efficient and comprehensive countermeasure against classic and emerging attacks, such as return-oriented programming. To motivate our design, we investigate the differences with application-level ASR and find that some of the wellestablished assumptions in existing solutions are no longer valid inside the OS; above all, perhaps, that information leakage becomes a major concern in the new context. We show that our ASR strategy outperforms stateof-the-art solutions in terms of both performance and security without affecting the software distribution model. Finally, we present the first comprehensive live rerandomization strategy, which we found to be particularly important inside the OS. Experimental results demonstrate that our techniques yield low run-time performance overhead (less than 5% on average on both SPEC and syscall-intensive benchmarks) and limited run-time memory footprint increase (around 15% during the execution of our benchmarks). We believe our techniques can greatly enhance the level of OS security without compromising the performance and reliability of the OS. |
Manual Evaluation of the Pelvic Floor : State of the Art and Evaluative Hypothesis | The pelvic floor is an anatomical area where the balance of different visceral, muscular and liquid pressures play a fundamental role in the physiological pursuit of the functions of all the structures contained therein. When the balance is broken, multiple disorders and pathologies arise, requiring conservative or surgical multidisciplinary treatments. The focus of this article is to propose a manual evaluation of the musculoskeletal structures of the pelvic floor since a complete palpatory examination taking into account the muscular, articular and ligamentous aspect of the pelvic area is currently missing. The detection of the abnormal area is a determining factor to organize properly the therapeutic work because, potentially resulting in better results. According to the Authors' knowledge, this is the first article in the current scientific landscape proposing a complete manual evaluation. |
Electro-thermal simulation of 1200 V 4H-SiC MOSFET short-circuit SOA† | The purpose of this paper is to introduce a dynamic electro-thermal simulation and analysis approach for device design and short-circuit safe-operating-area (SOA) characterization using a physics-based electro-thermal Saber®* model. Model parameter extraction, simulation, and validation results are given for several commercially available 4H-silicon carbide (SiC) power MOSFETs with a voltage rating of 1200 V and with current ratings of 31.6 A and 42 A. The electro-thermal model and simulations are used to analyze the short-circuit SOA including the measured failure time (tfailure) and simulated device internal junction temperature (Tj) at failure for different gate voltages (VGS) and drain voltages (VDS). |
The PSA testing dilemma: GPs' reports of consultations with asymptomatic men: a qualitative study | BACKGROUND
The National Health Service Prostate Cancer Risk Management Programme (PCRMP) has recommended that screening for prostate cancer is available for asymptomatic men, on the understanding that they have been provided with full and balanced information about the advantages and limitations of the prostate-specific antigen (PSA) test. Guidance has been distributed to all GPs in England and Wales to assist in the provision of information to men. This study aimed to elicit GPs' accounts of their discussions with asymptomatic men who consult with concerns about prostate cancer in order to identify the degree to which the PCRMP guidance was reflected in these consultations.
METHODS
Qualitative interview study. Semi-structured telephone interviews with 21 GPs from 18 GP practices in Oxfordshire.
RESULTS
All GPs reported undertaking some discussion with asymptomatic men about the PSA test. They described focussing most of the discussion on the false-positive and false-negative rates of the test, and the risks associated with a prostate biopsy. They reported less discussion of the potential for diagnosing indolent cancers, the dilemmas regarding treatment options for localised prostate cancer and the potential benefits of testing. Considerable variation existed between GPs in their accounts of the degree of detail given, and GP's presentation of information appeared to be affected by their personal views of the PSA test.
CONCLUSION
The GPs in this study appear to recognise the importance of discussions regarding PSA testing; however, a full and balanced picture of the associated advantages and limitations does not seem to be consistently conveyed. Factors specific to PSA testing which appeared to have an impact on the GPs' discussions were the GP's personal opinions of the PSA test, and the need to counter men's primarily positive views of the benefits of PSA testing. Awareness of the impact of their views on the consultations may help GPs give men a more balanced presentation of the benefits and limitations of the PSA test. |
Principles and Models for Organizing the IT Function | How should contemporary firms organize their IT function? Despite more than twenty years of experience and insights, this question continues to dominate the attention and interest of CIOs and senior business executives. During the 1970s and 1980s, firms alternated between centralized models (where authority for the majority of IT decisions was located in the corporate IT group) and decentralized models (where the authority for most IT decisions was located in the divisional or functional IT units). |
Hand hygiene-related clinical trials reported since 2010: a systematic review. | Considerable emphasis is currently placed on reducing healthcare-associated infection through improving hand hygiene compliance among healthcare professionals. There is also increasing discussion in the lay media of perceived poor hand hygiene compliance among healthcare staff. Our aim was to report the outcomes of a systematic search for peer-reviewed, published studies - especially clinical trials - that focused on hand hygiene compliance among healthcare professionals. Literature published between December 2009, after publication of the World Health Organization (WHO) hand hygiene guidelines, and February 2014, which was indexed in PubMed and CINAHL on the topic of hand hygiene compliance, was searched. Following examination of relevance and methodology of the 57 publications initially retrieved, 16 clinical trials were finally included in the review. The majority of studies were conducted in the USA and Europe. The intensive care unit emerged as the predominant focus of studies followed by facilities for care of the elderly. The category of healthcare worker most often the focus of the research was the nurse, followed by the healthcare assistant and the doctor. The unit of analysis reported for hand hygiene compliance was 'hand hygiene opportunity'; four studies adopted the 'my five moments for hand hygiene' framework, as set out in the WHO guidelines, whereas other papers focused on unique multimodal strategies of varying design. We concluded that adopting a multimodal approach to hand hygiene improvement intervention strategies, whether guided by the WHO framework or by another tested multimodal framework, results in moderate improvements in hand hygiene compliance. |
Active Tactile Transfer Learning for Object Discrimination in an Unstructured Environment Using Multimodal Robotic Skin | In this paper, we propose a probabilistic active tactile transfer learning (ATTL) method to enable robotic systems to exploit their prior tactile knowledge while discriminating among objects via their physical properties (surface texture, stiffness, and thermal conductivity). Using the proposed method, the robot autonomously selects and exploits its most relevant prior tactile knowledge to efficiently learn about new unknown objects with a few training samples or even one. The experimental results show that using our proposed method, the robot successfully discriminated among new objects with 72% discrimination accuracy using only one training sample (on-shot-tactile-learning). Furthermore, the results demonstrate that our method is robust against transferring irrelevant prior tactile knowledge (negative tactile knowledge transfer). |
Communities of practice and social learning systems 1 Communities of practice and social learning systems : the career of a concept | The concept of community of practice was not born in the systems theory tradition. It has its roots in attempts to develop accounts of the social nature of human learning inspired by anthropology and social theory (Lave, 1988; Bourdieu, 1977; Giddens, 1984; Foucault, 1980; Vygostsky, 1978). But the concept of community of practice is well aligned with the perspective of the systems tradition. A community of practice itself can be viewed as a simple social system. And a complex social system can be viewed as constituted by interrelated communities of practice. In this essay I first explore the systemic nature of the concept at these two levels. Then I use this foundation to look at the applications of the concept, some of its main critiques, and its potential for developing a social discipline of learning. |
Formation mechanism and optimization of highly luminescent N-doped graphene quantum dots | Photoluminescent graphene quantum dots (GQDs) have received enormous attention because of their unique chemical, electronic and optical properties. Here a series of GQDs were synthesized under hydrothermal processes in order to investigate the formation process and optical properties of N-doped GQDs. Citric acid (CA) was used as a carbon precursor and self-assembled into sheet structure in a basic condition and formed N-free GQD graphite framework through intermolecular dehydrolysis reaction. N-doped GQDs were prepared using a series of N-containing bases such as urea. Detailed structural and property studies demonstrated the formation mechanism of N-doped GQDs for tunable optical emissions. Hydrothermal conditions promote formation of amide between -NH₂ and -COOH with the presence of amine in the reaction. The intramoleculur dehydrolysis between neighbour amide and COOH groups led to formation of pyrrolic N in the graphene framework. Further, the pyrrolic N transformed to graphite N under hydrothermal conditions. N-doping results in a great improvement of PL quantum yield (QY) of GQDs. By optimized reaction conditions, the highest PL QY (94%) of N-doped GQDs was obtained using CA as a carbon source and ethylene diamine as a N source. The obtained N-doped GQDs exhibit an excitation-independent blue emission with single exponential lifetime decay. |
Recovering Non-Rigid 3D Shape from Image Streams | This paper addresses the problem of recovering 3D nonrigid shape models from image sequences. For example, given a video recording of a talking person, we would like to estimate a 3D model of the lips and the full face and its internal modes of variation. Many solutions that recover 3D shape from 2D image sequences have been proposed; these so-called structure-from-motion techniques usually assume that the 3D object is rigid. For example, Tomasi and Kanades’ factorization technique is based on a rigid shape matrix, which produces a tracking matrix of rank 3 under orthographic projection. We propose a novel technique based on a non-rigid model, where the 3D shape in each frame is a linear combination of a set of basis shapes. Under this model, the tracking matrix is of higher rank, and can be factored in a three-step process to yield pose, configuration and shape. To the best of our knowledge, this is the first model free approach that can recover from single-view video sequences nonrigid shape models. We demonstrate this new algorithm on several video sequences. We were able to recover 3D non-rigid human face and animal models with high accuracy. |
Sleep Architecture When Sleeping at an Unusual Circadian Time and Associations with Insulin Sensitivity | UNLABELLED
Circadian misalignment affects total sleep time, but it may also affect sleep architecture. The objectives of this study were to examine intra-individual effects of circadian misalignment on sleep architecture and inter-individual relationships between sleep stages, cortisol levels and insulin sensitivity. Thirteen subjects (7 men, 6 women, age: 24.3±2.5 y; BMI: 23.6±1.7 kg/m²) stayed in a time blinded respiration chamber during three light-entrained circadian cycles (3x21h and 3x27h) resulting in a phase advance and a phase delay. Sleep was polysomnographically recorded. Blood and salivary samples were collected to determine glucose, insulin and cortisol concentrations. Intra-individually, a phase advance decreased rapid eye movement (REM) sleep and slow-wave sleep (SWS), increased time awake, decreased sleep and REM sleep latency compared to the 24h cycle. A phase delay increased REM sleep, decreased stage 2 sleep, increased time awake, decreased sleep and REM sleep latency compared to the 24h cycle. Moreover, circadian misalignment changed REM sleep distribution with a relatively shorter REM sleep during the second part of the night. Inter-individually, REM sleep was inversely associated with cortisol levels and HOMA-IR index. Circadian misalignment, both a phase advance and a phase delay, significantly changed sleep architecture and resulted in a shift in rem sleep. Inter-individually, shorter REM sleep during the second part of the night was associated with dysregulation of the HPA-axis and reduced insulin sensitivity.
TRIAL REGISTRATION
International Clinical Trials Registry Platform NTR2926 http://apps.who.int/trialsearch/ |
Design of joint torque sensor and joint structure of a robot arm to minimize crosstalk and torque ripple | Torque control of a robot arm often requires joint torques which are measured using joint torque sensors. However, a joint torque sensor installed at a robot joint suffers from crosstalk errors and torque ripple. The crosstalk error generated by a moment load induces an offset to the torque sensor output. Furthermore, torque ripple noise generated by a harmonic drive interferes with accurate torque measurement as its amplitude is much higher than electric noise. In this study, novel methods are proposed to reduce crosstalk and torque ripple. The crosstalk is dealt with by specially designing the structure of a robot joint. Torque ripple is reduced by taking an average of two Wheatstone bridges outputs. The performance of the proposed robot joint was verified through various experiments. |
Animaux et arbres guingois | Betrema, J. and J.G. Penaud, Animaux et arbres guingois, Theoretical Computer Science 117 (1993) 67-89. The directed animals are put in a one-to-one correspondence with a kind of lop-sided trees, called guingois trees. Through this bijection, we get a simple coding for the animals; we show that this coding is related to a representation of animals by heaps of dimers. |
BEYOND BARBOUR OR BACK TO BASICS? THE FUTURE OF SCIENCE‐AND‐RELIGION AND THE QUEST FOR UNITY | Reflecting on the future of the field of science-and-reli- gion, I focus on three aspects. First, I describe the history of the reli- gion-and-science dialogue and argue that the emergence of the field was largely contingent on social-cultural factors in Western theology, especially in the United States. Next, I focus on the enormous influ- ence of science on Western society and on what I call cultural scientism, which influences discussions in science-and-religion, especially how theological notions are taken up. I illustrate by sketching the way divine action has been studied in science-and-religion. The divine- action debates may seem irrelevant to theologians because the way divine action is dealt with in science-and-religion is theologically prob- lematic. Finally, I analyze the quest for integration and unity of sci- ence and religion that underlies much of the contemporary field of science-and-religion and was stimulated particularly by the efforts of Ian Barbour. I argue that his quest echoes the logical positivist vision of unification and has a strong bias toward science as the sole source of rationality, which does not take theology fully seriously. |
Embedding gesture recognition into airplane seats for in-flight entertainment | In order to reduce both psychological and physical stress in air travel, sensors are integrated into airplane seats to detect gestures as input for in-flight entertainment systems. The content provided by the entertainment systems helps to reduce psychological stress, and gesture recognition is used as input for the content. The use of this system thus also stimulates passengers in limited seating space to make movements that would result in the reduction of physical stress. Preliminary user evaluation shows that users of the concept have significantly more active calf muscle pump activity in comparison with current situations and that users feel more active and less fatigued after a long period of sitting in the same position. |
Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial. | OBJECTIVE
Low vitamin D status has been associated with impaired glycemic control in patients with type 2 diabetes. The purpose of our study was to evaluate the effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS
This randomized, double-blind, placebo-controlled trial was conducted in 275 adult patients with type 2 diabetes without insulin treatment. Patients were randomly assigned to receive either vitamin D3 (50,000 IU/month) or placebo for 6 months. To assess the primary outcome of the study, change in HbA(1c), we performed a linear regression analysis.
RESULTS
Mean baseline serum 25-hydroxyvitamin D [25(OH)D] increased from 60.6 ± 23.3 to 101.4 ± 27.6 nmol/L and 59.1 ± 23.2 to 59.8 ± 23.2 nmol/L in the vitamin D and placebo group, respectively. Mean baseline HbA(1c) was 6.8 ± 0.5% (51 ± 6 mmol/mol) in both groups. After 6 months, no effect was seen on HbA(1c) (mean difference: β = 0.4 [95% CI -0.6 to 1.5]; P = 0.42) and other indicators of glycemic control (HOMA of insulin resistance, fasting insulin, and glucose) in the entire study population. Subgroup analysis in patients with a serum 25(OH)D <50 nmol/L or an HbA(1c) level >7% (53 mmol/mol) did not differ the results.
CONCLUSIONS
In a well-controlled group of patients with type 2 diabetes, intermittent high-dose vitamin D supplementation did not improve glycemic control. |
Emerging contaminants of public health significance as water quality indicator compounds in the urban water cycle. | The contamination of the urban water cycle (UWC) with a wide array of emerging organic compounds (EOCs) increases with urbanization and population density. To produce drinking water from the UWC requires close examination of their sources, occurrence, pathways, and health effects and the efficacy of wastewater treatment and natural attenuation processes that may occur in surface water bodies and groundwater. This paper researches in details the structure of the UWC and investigates the routes by which the water cycle is increasingly contaminated with compounds generated from various anthropogenic activities. Along with a thorough survey of chemicals representing compound classes such as hormones, antibiotics, surfactants, endocrine disruptors, human and veterinary pharmaceuticals, X-ray contrast media, pesticides and metabolites, disinfection-by-products, algal toxins and taste-and-odor compounds, this paper provides a comprehensive and holistic review of the occurrence, fate, transport and potential health impact of the emerging organic contaminants of the UWC. This study also illustrates the widespread distribution of the emerging organic contaminants in the different aortas of the ecosystem and focuses on future research needs. |
Phase II Study of Rituximab in Combinat ion With CHOP Chemotherapy in Pat ients With Prev ious ly Untreated , Aggress ive Non-Hodgkin ’ s Lymphoma | Purpose: To determine the safety and efficacy of the combination of the chimeric anti-CD20 antibody Rituxan (rituximab, IDEC-C2B8; Genentech Inc, South San Francisco, CA) and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy in patients with aggressive non-Hodgkin’s lymphoma (NHL). Patients and Methods: Thirty-three patients with previously untreated advanced aggressive B-cell NHL received six infusions of Rituxan (375 mg/m2 per dose) on day 1 of each cycle in combination with six doses of CHOP chemotherapy given on day 3 of each cycle. Results: The ORR by investigator assessment confirmed by the sponsor was 94% (31 of 33 patients). Twenty patients experienced a complete response (CR) (61%), 11 patients had a partial response (PR) (33%), and two patients were classified as having progressive disease. In the 18 patients with an International Prognostic Index (IPI) score > 2, the combination of Rituxan plus CHOP achieved an ORR of 89% and CR of 56%. The median duration of response and time to progression had not been reached after a median observation time of 26 months. Twenty-nine of 31 responding patients remained in remission during this follow-up period, including 15 of 16 patients with an IPI score > 2. The most frequent adverse events attributed to Rituxan were fever and chills, primarily during the first infusion. Rituxan did not seem to compromise the ability of patients to tolerate CHOP; all patients completed the entire six courses of the combination. The bcl-2 translocation of blood or bone marrow was positive at baseline in 13 patients; 11 patients had follow-up specimens obtained (eight CR, three PR), and all had a negative bcl-2 status after therapy. Only one patient has reconverted to bcl-2 positivity, and all patients remain in clinical remission. Conclusion: This is the first report to demonstrate the safety and efficacy of the Rituxan chimeric anti-CD20 antibody in combination with standard-dose CHOP in the treatment of aggressive B-cell lymphoma. The clinical responses are at least comparable to those achieved with CHOP alone with no significant added toxicity. The presence or absence of the bcl-2 translocation did not affect the ability of patients to achieve a CR with this regimen. The ability to achieve sustained remissions in patients with an IPI score > 2 warrants further investigation with a randomized study. J Clin Oncol 19:389-397. © 2001 by American Society of Clinical Oncology. |
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability | A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption. This analysis uses a transport model and human permeability results for estimating in vivo drug absorption to illustrate the primary importance of solubility and permeability on drug absorption. The fundamental parameters which define oral drug absorption in humans resulting from this analysis are discussed and used as a basis for this classification scheme. These Biopharmaceutic Drug Classes are defined as: Case 1. High solubility-high permeability drugs, Case 2. Low solubility-high permeability drugs, Case 3. High solubility-low permeability drugs, and Case 4. Low solubility-low permeability drugs. Based on this classification scheme, suggestions are made for setting standards for in vitro drug dissolution testing methodology which will correlate with the in vivo process. This methodology must be based on the physiological and physical chemical properties controlling drug absorption. This analysis points out conditions under which no in vitro-in vivo correlation may be expected e.g. rapidly dissolving low permeability drugs. Furthermore, it is suggested for example that for very rapidly dissolving high solubility drugs, e.g. 85% dissolution in less than 15 minutes, a simple one point dissolution test, is all that may be needed to insure bioavailability. For slowly dissolving drugs a dissolution profile is required with multiple time points in systems which would include low pH, physiological pH, and surfactants and the in vitro conditions should mimic the in vivo processes. This classification scheme provides a basis for establishing in vitro-in vivo correlations and for estimating the absorption of drugs based on the fundamental dissolution and permeability properties of physiologic importance. |
Modeling driver behavior at roundabouts: Results from a field study | Advanced Driving Assistance Systems could improve driving safety and comfort by supporting drivers in their driving task. To realize intelligent assistance, driver behavior prediction and recognition is an important challenge. Therefore, the aim of this study is to develop a method to predict whether a vehicle, having entered a roundabout, will choose an upcoming exit or stay within the roundabout. A field study has been conducted to collect driving behavior data for analyzing and modeling human driver behavior in interaction with roundabouts. Support vector machines proved to be a robust and efficient classification method for the roundabout leaving/ staying pattern recognition problem. From the experimental results the vehicles position can be estimated, for which the prediction becomes reliable. The steering wheel angle and angle velocity also proved to be able to provide sufficient information to predict the driver behavior at the investigated roundabouts. |
Basic Process Algebra with Iteration: Completeness of its Equational Axioms | Bergstra, Bethke and Ponse proposed an axiomatization for Basic Process Algebra extended with (binary) iteration. In this paper, we prove that this axiomatization is complete with respect to strong bisimulation equivalence. To obtain this result, we will set up a term rewriting system, based on the axioms, and prove that this term rewriting system is terminating, and that bisimilar normal forms are syntactically equal modulo commutativity and associativity of the +. |
Expert System for Blast Furnace Operation | Quality improvement has become a major focus in the steel industry during the 1980's. Improvements in product quality can be achieved by upgrading and replacing equipment or by standardizing operating procedures and practices. Since upgrading and replacing equipment requires large capital investments, the logical choice for enhancing quality is through operation standardization. Once practices and procedures have been standardized through use of statistical studies and recording operators' knowledge, these can be placed into a computer in the form of an “EXPERT SYSTEM.”
In 1989, Inland Steel in cooperation with Purdue University Calumet began a program to place the Blast Furnace Standard Operations manual into an expert system. The goal of this program is to have the computer recommend operating variable changes to the blast furnace supervisor. Because of the nature of furnaces, the time delay between the operating variables and the operating indicators, our expert system contains a journal as well. |
Fully Homomorphic Encryption with Polylog Overhead | We show that homomorphic evaluation of (wide enough) arithmetic circuits can be accomplished with only polylogarithmic overhead. Namely, we present a construction of fully homomorphic encryption (FHE) schemes that for security parameter λ can evaluate any width-Ω(λ) circuit with t gates in time t · polylog(λ). To get low overhead, we use the recent batch homomorphic evaluation techniques of Smart-Vercauteren and Brakerski-Gentry-Vaikuntanathan, who showed that homomorphic operations can be applied to “packed” ciphertexts that encrypt vectors of plaintext elements. In this work, we introduce permuting/routing techniques to move plaintext elements across these vectors efficiently. Hence, we are able to implement general arithmetic circuit in a batched fashion without ever needing to “unpack” the |
Personality Recognition in Source Code Working Note: Team BESUMich | In this paper, we describe the results of source code personality identification from Team BESUMich. We used a set of simple, robust, scalable, and language-independent features on the PR-SOCO dataset. Using leave-one-coder-out strategy, we obtained minimum RMSE on the test data for extroversion, and competitive results for other personality traits. |
Paul and the Religious Experience of Reconciliation: Diasporic Community and Creole Consciousness | In the ancient world as in contemporary times, religion provides a vital context in which people become who they are and establish themselves with a unique identity. This process of constructing the self is not only a psychological process and a phenomenological reality; it can also be a deeply religious experience. |
Towards Autonomic DDoS Mitigation using Software Defined Networking | Distributed Denial of Service attacks (DDoS) have remained as one of the most destructive attacks in the Internet for over two decades. Despite tremendous efforts on the design of DDoS defense strategies, few of them have been considered for widespread deployment due to strong design assumptions on the Internet infrastructure, prohibitive operational costs and complexity. Recently, the emergence of Software Defined Networking (SDN) has offered a solution to reduce network management complexity. It is also believed to facilitate security management thanks to its programmability. To explore the advantages of using SDN to mitigate DDoS attacks, we propose a distributed collaborative framework that allows the customers to request DDoS mitigation service from ISPs. Upon request, ISPs can change the label of the anomalous traffic and redirect them to security middleboxes, while attack detection and analysis modules are deployed at customer side, avoiding privacy leakage and other legal concerns. Our preliminary analysis demonstrates that SDN has promising potential to enable autonomic mitigation of DDoS attacks, as well as other large-scale attacks. |
Analyzing the transitional region in low power wireless links | The wireless sensor networks community, has now an increased understanding of the need for realistic link layer models. Recent experimental studies have shown that real deployments have a "transitional region" with highly unreliable links, and that therefore the idealized perfect-reception-within-range models used in common network simulation tools can be very misleading. In this paper, we use mathematical techniques from communication theory to model and analyze the low power wireless links. The primary contribution of this work is the identification of the causes of the transitional region, and a quantification of their influence. Specifically, we derive expressions for the packet reception rate as a function of distance, and for the width of the transitional region. These expressions incorporate important channel and radio parameters such as the path loss exponent and shadowing variance of the channel; and the modulation and encoding of the radio. A key finding is that for radios using narrow-band modulation, the transitional region is not an artifact of the radio non-ideality, as it would exist even with perfect-threshold receivers because of multi-path fading. However, we hypothesize that radios with mechanisms to combat multi-path effects, such as spread-spectrum and diversity techniques, can reduce the transitional region. |
Open source computer-vision based guidance system for UAVs on-board decision making | The use of UAVs for remote sensing tasks; e.g. agriculture, search and rescue is increasing. The ability for UAVs to autonomously find a target and perform on-board decision making, such as descending to a new altitude or landing next to a target is a desired capability. Computer-vision functionality allows the Unmanned Aerial Vehicle (UAV) to follow a designated flight plan, detect an object of interest, and change its planned path. In this paper we describe a low cost and an open source system where all image processing is achieved on-board the UAV using a Raspberry Pi 2 microprocessor interfaced with a camera. The Raspberry Pi and the autopilot are physically connected through serial and communicate via MAVProxy. The Raspberry Pi continuously monitors the flight path in real time through USB camera module. The algorithm checks whether the target is captured or not. If the target is detected, the position of the object in frame is represented in Cartesian coordinates and converted into estimate GPS coordinates. In parallel, the autopilot receives the target location approximate GPS and makes a decision to guide the UAV to a new location. This system also has potential uses in the field of Precision Agriculture, plant pest detection and disease outbreaks which cause detrimental financial damage to crop yields if not detected early on. Results show the algorithm is accurate to detect 99% of object of interest and the UAV is capable of navigation and doing on-board decision making. |
Granola: Low-Overhead Distributed Transaction Coordination | This paper presents Granola, a transaction coordination infrastructure for building reliable distributed storage applications. Granola provides a strong consistency model, while significantly reducing transaction coordination overhead. We introduce specific support for a new type of independent distributed transaction, which we can serialize with no locking overhead and no aborts due to write conflicts. Granola uses a novel timestamp-based coordination mechanism to order distributed transactions, offering lower latency and higher throughput than previous systems that offer strong consistency. Our experiments show that Granola has low overhead, is scalable and has high throughput. We implemented the TPC-C benchmark on Granola, and achieved 3× the throughput of a platform using a locking approach. |
Amino acid analysis: aqueous dimethyl sulfoxide as solvent for the ninhydrin reaction. | Methyl Cellosolve (the monomethyl ether of ethylene glycol) has been widely used as the organic solvent in ninhydrin reagents for amino acid analysis; it has, however, properties that are disadvantageous in a reagent for everyday employment. The solvent is toxic and it is difficult to keep the ether peroxide-free. A continuing effort to arrive at a chemically preferable and relatively nontoxic substitute for methyl Cellosolve has led to experiments with dimethyl s&oxide, which proves to be a better solvent for the reduced form of ninhydrin (hydrindantin) than is methyl Cellosolve. Dimethyl sulfoxide can replace the latter, volume for volume, in a ninhydrin reagent mixture that gives equal performance and has improved stability. The result is a ninhydrin-hydrindantin solution in 75% dimethyl sulfoxide25 % 4 M lithium acetate buffer at pH 5.2. This type of mixture, with appropriate hydrindantin concentrations, is recommended to replace methyl Cellosolve-containing reagents in the quantitative determination of amino acids by automatic analyzers and by the manual ninhydrin method. |
A compact 12-watt high-efficiency 2.1-2.7 GHz class-E GaN HEMT power amplifier for base stations | A compact broadband class-E power amplifier design is presented. High broadband power efficiency is observed from 2.0–2.5 GHz, where drain efficiency ≫74% and PAE ≫71%, when using 2nd-harmonic input tuning. The highest in-band efficiency performance is observed at 2.14 GHz from a 40V supply with peak drain-efficiency of 77.3% and peak PAE of 74.0% at 12W output power and 14dB gain. The best broadband output power performance is observed from 2.1–2.7 GHz without 2nd-harmonic input tuning, where the output power variation is within 1.5dB and power efficiency is between 53% and 66%. |
Incorporating depth into both CNN and CRF for indoor semantic segmentation | To improve segmentation performance, a novel neural network architecture (termed DFCN-DCRF) is proposed, which combines an RGB-D fully convolutional neural network (DFCN) with a depth-sensitive fully-connected conditional random field (DCRF). First, a DFCN architecture which fuses depth information into the early layers and applies dilated convolution for later contextual reasoning is designed. Then, a depth-sensitive fully-connected conditional random field (DCRF) is proposed and combined with the previous DFCN to refine the preliminary result. Comparative experiments show that the proposed DFCN-DCRF achieves competitive performance compared with state-of-the-art methods. |
What Is Seen Is Who You Are: Are Cues in Selfie Pictures Related to Personality Characteristics? | Developments and innovation in the areas of mobile information technology, digital media and social networks foster new reflections on computer-mediated communication research, especially in the field of self-presentation. In this context, the selfie as a self-portrait photo is interesting, because as a meaningful gesture, it actively and directly relates the content of the photo to the author of the picture. From the perspective of the selfie as an image and the impression it forms, in the first part of the research we explored the distinctive characteristics of selfie pictures; moreover, from the perspective of the potential reflection of a selfie image on the personality of its author, in the second part we related the characteristics of selfie pictures to various personality constructs (e.g., Big Five personality traits narcissism and femininity-masculinity). Important aspects of selfies especially in relation to gender include the tilt of the head, the side of the face exhibited, mood and head position, later related also to the context of the selfie picture. We found no significant relations between selfie cues and personality constructs. The face-ism index was related to entitlement, and selfie availability to neuroticism. |
Prospective blinded comparison of wireless capsule endoscopy and multiphase CT enterography in obscure gastrointestinal bleeding. | PURPOSE
To compare the performance of multiphase computed tomographic (CT) enterography with that of capsule endoscopy in a group of patients with obscure gastrointestinal bleeding (OGIB).
MATERIALS AND METHODS
This prospective HIPAA-compliant study was approved by the institutional review board and the institutional conflict of interest committee. All patients provided written informed consent. Two radiologists, blinded to clinical data and results of capsule endoscopy, interpreted images from CT enterography independently, with discordant interpretations resolved by consensus. Results were compared with those from a reference standard (surgery or endoscopy) and clinical follow-up. Sensitivity and 95% confidence intervals were calculated for each modality.
RESULTS
Fifty-eight adult patients, referred for the evaluation of OGIB (occult, 25 patients [43%]; overt, 33 patients [57%]), underwent both tests. A small bowel bleeding source was identified in 16 of the 58 patients (28%). The sensitivity of CT enterography was significantly greater than that of capsule endoscopy (88% [14 of 16 patients] vs 38% [six of 16 patients], respectively; P = .008), largely because it depicted more small bowel masses (100% [nine of nine patients] vs 33% [three of nine patients], respectively; P = .03). No additional small bowel tumors were discovered during the follow-up period (range, 5.6-45.9 months; mean, 16.6 months).
CONCLUSION
In this referral population, the sensitivity of CT enterography for detecting small bowel bleeding sources and small bowel masses was significantly greater than that of capsule endoscopy. On the basis of these findings, the addition of multiphase CT enterography to the routine diagnostic work-up of patients with OGIB should be considered, particularly in patients with negative findings at capsule endoscopy. |
Forecasting Popularity of Videos Using Social Media | This paper presents a systematic online prediction method (Social-Forecast) that is capable to accurately forecast the popularity of videos promoted by social media. Social-Forecast explicitly considers the dynamically changing and evolving propagation patterns of videos in social media when making popularity forecasts, thereby being situation and context aware. Social-Forecast aims to maximize the forecast reward, which is defined as a tradeoff between the popularity prediction accuracy and the timeliness with which a prediction is issued. The forecasting is performed online and requires no training phase or a priori knowledge. We analytically bound the prediction performance loss of Social-Forecast as compared to that obtained by an omniscient oracle and prove that the bound is sublinear in the number of video arrivals, thereby guaranteeing its short-term performance as well as its asymptotic convergence to the optimal performance. In addition, we conduct extensive experiments using real-world data traces collected from the videos shared in RenRen, one of the largest online social networks in China. These experiments show that our proposed method outperforms existing view-based approaches for popularity prediction (which are not context-aware) by more than 30% in terms of prediction rewards. |
Artificial intelligence in medicine. | Artificial Intelligence (AI) is a general term that implies the use of a computer to model intelligent behavior with minimal human intervention. AI is generally accepted as having started with the invention of robots. The term derives from the Czech word robota, meaning biosynthetic machines used as forced labor. In this field, Leonardo Da Vinci's lasting heritage is today's burgeoning use of robotic-assisted surgery, named after him, for complex urologic and gynecologic procedures. Da Vinci's sketchbooks of robots helped set the stage for this innovation. AI, described as the science and engineering of making intelligent machines, was officially born in 1956. The term is applicable to a broad range of items in medicine such as robotics, medical diagnosis, medical statistics, and human biology-up to and including today's "omics". AI in medicine, which is the focus of this review, has two main branches: virtual and physical. The virtual branch includes informatics approaches from deep learning information management to control of health management systems, including electronic health records, and active guidance of physicians in their treatment decisions. The physical branch is best represented by robots used to assist the elderly patient or the attending surgeon. Also embodied in this branch are targeted nanorobots, a unique new drug delivery system. The societal and ethical complexities of these applications require further reflection, proof of their medical utility, economic value, and development of interdisciplinary strategies for their wider application. |
Fancy a gene? A surprisingly complex evolutionary history of peroxiredoxins. | While the phylum Apicomplexa includes "only" several thousand described species of obligatory parasites of animals, it may in fact be the most specious group of parasitic protists with over a million species 1. The best known representatives are Plasmodium spp., Toxoplasma gondii and Cryptosporidium spp., which belong to the most important and widespread human parasites exacting an enormous disease burden. On the other hand, dinoflagellates and colpodellids, which are monophyletic with the apicomplexans, are ecologically highly significant, as they belong to the most abundant marine protists 2. As the common ancestor of these groups was most likely a free-living photosynthesizing protist, one wonders, which evolutionary forces contributed to the dramatic transition of some of its descendants into the arguably most successful intracellular parasites? Although a range of various processes and mechanisms contributed to this transition, most likely it also involved an acquisition of genes via horizontal gene transfer (HGT), which might have provided typical characteristics of a parasitic cell, such as immune escape, nutritional dependence and the capacity to invade other cells. |
Recommended dose of arbekacin, an aminoglycoside against methicillin-resistant Staphylococcus aureus, does not achieve desired serum concentration in critically ill patients with lowered creatinine clearance. | OBJECTIVE
To define the pharmacokinetics of arbekacin (ABK), an aminoglycoside, in patients with acutely lowered renal function.
METHODS
We measured the serum concentrations of ABK, using fluorescence polarization immunoassay, in 10 critically ill patients (patient group) and six healthy volunteers (control group). Data were analysed with a two-compartment model and parameters were estimated by the Bayesian method. The Mann-Whitney U-test or chi-squared test was used as appropriate (P < 0.05).
RESULTS
Creatinine clearance (CCR), measured or estimated using Cockcroft and Gault's formula of the patient group (CCR: 58 +/- 13 mL/min), was significantly lower than that of the control group (CCR: 99 +/- 8 mL/min). However, despite the low CCR, even the maintenance ABK dosage for normal CCR did not elevate the highest serum level (C(max)) to the effective range in the patient group. Although the ABK clearance (CL) did not differ between the groups, the patients' distribution volume (V(d)) increased significantly compared with the control. The transfer rate constant from central to peripheral compartment (k(12)) in the patient group was much higher than that in the control.
CONCLUSION
In critically ill patients with lowered CCR, the ABK dose for normal CCR subjects does not elevate its serum concentration to effective levels because of augmented V(d) caused by increased k(12). The present results hypothesize that adjustment of antibiotic dosing according to CCR further lowers C(max) in critically ill patients with reduced CCR. |
Duplication of 7p12.1-p13, including GRB10 and IGFBP1, in a mother and daughter with features of Silver-Russell syndrome | Silver-Russell syndrome (SRS) has been associated with maternal uniparental disomy (UPD) of chromosome 7 in approximately 10% of cases, suggesting that at least one imprinted gene on chromosome 7 is involved in the pathogenesis of the disease. We report a proximal 7p interstitial inverted duplication in a mother and daughter both of whom have features of SRS, including marked short stature, low birth weight, facial asymmetry and 5th finger clinodactyly. Fluorescence in situ hybridisation (FISH) with YAC probes enabled delineation of the duplicated region to 7p12.1–p13. This region of proximal chromosome 7 is known to be homologous to an imprinted region in the mouse chromosome 11 and contains the growth-related genes GRB10 (growth factor receptor-bound protein 10), EGFR (epidermal growth factor receptor) and IGFBP1 (insulin-like growth factor binding protein 1), all of which have been suggested as candidate genes for SRS. Molecular analysis showed that the duplication in both mother and daughter spanned a distance of ~10 cM and included GRB10 and IGFBP1 but not EGFR. The de novo duplication in the proband's mother was shown to be of paternal origin. In order to test the hypothesis that sub-microscopic duplications of 7p, whether maternal or paternal in origin, are responsible for at least some cases of SRS, we screened a further eight patients referred to our laboratory for SRS. None were found to have duplications of either GRB10 or IGFBP1. The hypothesis that sub-microscopic duplications including GRB10 and IGFBP1 is a cause of SRS remains a possibility and warrants further investigation. Importantly, in contrast to current thinking, our results suggest that imprinted genes may not underlie the SRS phenotype, and we propose an alternative hypothesis to explain the occurrence of maternal UPD 7 seen in some cases of SRS. |
The Children’s Attention Project: a community-based longitudinal study of children with ADHD and non-ADHD controls | BACKGROUND
Attention-Deficit/Hyperactivity Disorder (ADHD) affects approximately 5% of children worldwide and results in significant impairments in daily functioning. Few community-ascertained samples of children with ADHD have been studied prospectively to identify factors associated with differential outcomes. The Children's Attention Project is the first such study in Australia, examining the mental health, social, academic and quality of life outcomes for children with diagnostically-confirmed ADHD compared to non-ADHD controls. The study aims to map the course of ADHD symptoms over time and to identify risk and protective factors associated with differential outcomes.
METHODS/DESIGN
The sample for this prospective longitudinal study is being recruited across 43 socio-economically diverse primary schools across Melbourne, Australia. All children in Grade 1, the second year of formal schooling (6-8 years), are screened for ADHD symptoms using independent parent and teacher reports on the Conners' 3 ADHD index (~N = 5260). Children screening positive for ADHD by both parent and teacher report, and a matched sample (gender, school) screening negative, are invited to participate in the longitudinal study. At baseline this involves parent completion of the NIMH Diagnostic Interview Schedule for Children IV (DISC-IV) to confirm likely ADHD diagnostic status and identify other mental health difficulties, direct child assessments (cognitive, academic, language and executive functioning; height and weight) and questionnaires for parents and teachers assessing outcomes, as well as a broad range of risk and protective factors (child, parent/family, teacher/school, and socio-economic factors). Families will be initially followed up for 3 years.
DISCUSSION
This study is the first Australian longitudinal study of children with ADHD and one of the first community-based longitudinal studies of diagnostically confirmed children with ADHD. The study's examination of a broad range of risk and protective factors and ADHD-related outcomes has the potential to inform novel strategies for intervention and prevention. |
Long-term effect of continuous positive airway pressure in hypertensive patients with sleep apnea. | RATIONALE
Continuous positive airway pressure (CPAP) is the current treatment for patients with symptomatic obstructive sleep apnea (OSA). Its use for all subjects with sleep-disordered breathing, regardless of daytime symptoms, is unclear.
OBJECTIVES
This multicenter controlled trial assesses the effects of 1 year of CPAP treatment on blood pressure (BP) in nonsymptomatic, hypertensive patients with OSA.
METHODS
We evaluated 359 patients with OSA. Inclusion criteria consisted of an apnea-hypopnea index (AHI) greater than 19 hour(-1), an Epworth Sleepiness Scale score less than 11, and one of the following: under antihypertensive treatment or systolic blood pressure greater than 140 or diastolic blood pressure greater than 90 mm Hg. Patients were randomized to CPAP (n = 178) or to conservative treatment (n = 181). BP was evaluated at baseline and at 3, 6, and 12 months of follow-up.
MEASUREMENTS AND MAIN RESULTS
Mean (SD) values were as follows: age, 56 +/- 10 years; body mass index (BMI), 32 +/- 5 kg x m(-2); AHI, 45 +/- 20 hour(-1); and Epworth Sleepiness Scale score, 7 +/- 3. After adjusting for follow-up time, baseline blood pressure values, AHI, time with arterial oxygen saturation less than 90%, and BMI, together with the change in BMI at follow-up, CPAP treatment decreased systolic blood pressure by 1.89 mm Hg (95% confidence interval: -3.90, 0.11 mm Hg; P = 0.0654), and diastolic blood pressure by 2.19 mm Hg (95% confidence interval: -3.46, -0.93 mm Hg; P = 0.0008). The most significant reduction in BP was in patients who used CPAP for more than 5.6 hours per night. CPAP compliance was related to AHI and the decrease in Epworth Sleepiness Scale score.
CONCLUSIONS
In nonsleepy hypertensive patients with OSA, CPAP treatment for 1 year is associated with a small decrease in BP. This effect is evident only in patients who use CPAP for more than 5.6 hours per night. Clinical trial registered with www.clinicaltrials.gov (NCT00127348). |
A Proposed Curriculum in Cybersecurity Education Targeting Homeland Security Students | Homeland Security (HS) is a growing field of study in the U.S. today, generally covering risk management, terrorism studies, policy development, and other topics related to the broad field. Information security threats to both the public and private sectors are growing in intensity, frequency, and severity, and are a very real threat to the security of the nation. While there are many models for information security education at all levels of higher education, these programs are invariably offered as a technical course of study, these curricula are generally not well suited to HS students. As a result, information systems and cyber security principles are under represented in the typical HS program. The authors propose a course of study in cyber security designed to capitalize on the intellectual strengths of students in this discipline and that are consistent with the broad suite of professional needs in this discipline. |
The facial flow concept: An organic orofacial analysis-the vertical component. | Orofacial analysis has been used by dentists for many years. The process involves applying mathematical rules, geometric principles, and straight lines to create either parallel or perpendicular references based on the true horizon and/or natural head position. These reference lines guide treatment planning and smile design for restorative treatments to achieve harmony between the new smile and the face. The goal is to obtain harmony and not symmetry. Faces are asymmetrical entities and because of that cannot be analyzed using purely straight lines. In this article, a more natural, organic, and dynamic process of evaluation is presented to minimize errors and generate harmoniously balanced smiles instead of perfect, mathematical smiles. |
Executing SPARQL Queries over the Web of Linked Data | The Web of Linked Data forms a single, globally distributed dataspace. Due to the openness of this dataspace, it is not possible to know in advance all data sources that might be relevant for query answering. This openness poses a new challenge that is not addressed by traditional research on federated query processing. In this paper we present an approach to execute SPARQL queries over the Web of Linked Data. The main idea of our approach is to discover data that might be relevant for answering a query during the query execution itself. This discovery is driven by following RDF links between data sources based on URIs in the query and in partial results. The URIs are resolved over the HTTP protocol into RDF data which is continuously added to the queried dataset. This paper describes concepts and algorithms to implement our approach using an iterator-based pipeline. We introduce a formalization of the pipelining approach and show that classical iterators may cause blocking due to the latency of HTTP requests. To avoid blocking, we propose an extension of the iterator paradigm. The evaluation of our approach shows its strengths as well as the still existing challenges. |
How does capital affect bank performance during financial crises ? $ | This paper empirically examines how capital affects a bank’s performance (survival and market share) and how this effect varies across banking crises, market crises, and normal times that occurred in the US over the past quarter century. We have two main results. First, capital helps small banks to increase their probability of survival and market share at all times (during banking crises, market crises, and normal times). Second, capital enhances the performance of medium and large banks primarily during banking crises. Additional tests explore channels through which capital generates these effects. Numerous robustness checks and additional tests are performed. & 2013 Elsevier B.V. All rights reserved. |
Total knee arthroplasty in Asian subjects: preoperative range of motion determines postoperative range of motion? | OBJECTIVE
To evaluate whether preoperative range of motion is a key determinant of postoperative range of motion in Asian patients undergoing conventional total knee arthroplasty.
METHODS
A retrospective review of 302 patients who underwent primary total knee arthroplasty performed by a single surgeon was conducted. Patients who had a fixed flexion deformity of ≥15° were excluded. Postoperative range of motion (ROM) was measured prospectively. Patients were stratified into two groups: preoperative ROM < 110° and preoperative ROM ≥ 110°. Postoperative ROM and mean change in ROM at 6 months and 2 years of follow-up were then compared using Student's t-test.
RESULTS
Group of ROM < 110° had a poorer postoperative range of motion at both 6-months and 2-years of follow-up than Group of ROM ≥ 110° (P < 0.001). Postoperatively, Group of ROM < 110° had gained range of motion whereas Group of ROM ≥ 110° had lost range of motion (P < 0.001).
CONCLUSIONS
Similar to the Western population, preoperative range of motion is a key determinant of postoperative range of motion in Asian patients. This should be taken into consideration by surgeons during preoperative planning and in managing patients' expectations. |
Reliable and efficient autonomous driving: the need for heterogeneous vehicular networks | Autonomous driving technology has been regarded as a promising solution to reduce road accidents and traffic congestion, as well as to optimize the usage of fuel and lane. Reliable and highly efficient vehicle-to-vehicle and vehicle-to-infrastructure communications are essential for commercial autonomous driving vehicles to be on the road before 2020. The current article first presents the concept of heterogeneous vehicular networks (HetVNETs) for autonomous driving, in which an improved protocol stack is proposed to satisfy the communication requirements of not only safety but also non-safety services. We then consider and study in detail several typical scenarios for autonomous driving. In order to tackle the potential challenges raised by the autonomous driving vehicles in HetVNETs, new techniques from transmission to networking are proposed as potential solutions. |
Interactive Learning of Spatial Knowledge for Text to 3D Scene Generation | We present an interactive text to 3D scene generation system that learns the expected spatial layout of objects from data. A user provides input natural language text from which we extract explicit constraints on the objects that should appear in the scene. Given these explicit constraints, the system then uses prior observations of spatial arrangements in a database of scenes to infer the most likely layout of the objects in the scene. Through further user interaction, the system gradually adjusts and improves its estimates of where objects should be placed. We present example generated scenes and user interaction scenarios. |
An Evaluation of Aggregation Techniques in Crowdsourcing | As the volumes of AI problems involving human knowledge are likely to soar, crowdsourcing has become essential in a wide range of world-wide-web applications. One of the biggest challenges of crowdsourcing is aggregating the answers collected from the crowd since the workers might have wide-ranging levels of expertise. In order to tackle this challenge, many aggregation techniques have been proposed. These techniques, however, have never been compared and analyzed under the same setting, rendering a ‘right’ choice for a particular application very difficult. Addressing this problem, this paper presents a benchmark that offers a comprehensive empirical study on the performance comparison of the aggregation techniques. Specifically, we integrated several stateof-the-art methods in a comparable manner, and measured various performance metrics with our benchmark, including computation time, accuracy, robustness to spammers, and adaptivity to multi-labeling. We then provide in-depth analysis of benchmarking results, obtained by simulating the crowdsourcing process with different types of workers. We believe that the findings from the benchmark will be able to serve as a practical guideline for crowdsourcing applications. |
Meta4meaning: Automatic Metaphor Interpretation Using Corpus-Derived Word Associations | We propose a novel metaphor interpretation method, Meta4meaning. It provides interpretations for nominal metaphors by generating a list of properties that the metaphor expresses. Meta4meaning uses word associations extracted from a corpus to retrieve an approximation to properties of concepts. Interpretations are then obtained as an aggregation or difference of the saliences of the properties to the tenor and the vehicle. We evaluate Meta4meaning using a set of humanannotated interpretations of 84 metaphors and compare with two existing methods for metaphor interpretation. Meta4meaning significantly outperforms the previous methods on this task. |
Dynamic Social Network Analysis of a Dark Network: Identifying Significant Facilitators | "Dark Networks" refer to various illegal and covert social networks like criminal and terrorist networks. These networks evolve over time with the formation and dissolution of links to survive control efforts by authorities. Previous studies have shown that the link formation process in such networks is influenced by a set of facilitators. However, there have been few empirical evaluations to determine the significant facilitators. In this study, we used dynamic social network analysis methods to examine several plausible link formation facilitators in a large-scale real-world narcotics network. Multivariate Cox regression showed that mutual acquaintance and vehicle affiliations were significant facilitators in the network under study. These findings provide insights into the link formation processes and the resilience of dark networks. They also can be used to help authorities predict co-offending in future crimes. |
A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus | Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients with autoimmune diseases. We recently identified miR-146a as a negative regulator of the interferon pathway and linked the abnormal activation of this pathway to the underexpression of miR-146a in SLE patients. To explore why the expression of miR-146a is reduced in SLE patients, we conducted short parallel sequencing of potentially regulatory regions of miR-146a and identified a novel genetic variant (rs57095329) in the promoter region exhibiting evidence for association with SLE that was replicated independently in 7,182 Asians (P(meta) = 2.74×10(-8), odds ratio = 1.29 [1.18-1.40]). The risk-associated G allele was linked to reduced expression of miR-146a in the peripheral blood leukocytes of the controls. Combined functional assays showed that the risk-associated G allele reduced the protein-binding affinity and activity of the promoter compared with those of the promoter containing the protective A allele. Transcription factor Ets-1, encoded by the lupus-susceptibility gene ETS1, identified in recent genome-wide association studies, binds near this variant. The manipulation of Ets-1 levels strongly affected miR-146a promoter activity in vitro; and the knockdown of Ets-1, mimicking its reduced expression in SLE, directly impaired the induction of miR-146a. We also observed additive effects of the risk alleles of miR-146a and ETS1. Our data identified and confirmed an association between a functional promoter variant of miR-146a and SLE. This risk allele had decreased binding to transcription factor Ets-1, contributing to reduced levels of miR-146a in SLE patients. |
On the Equivalence of Logic-Based Argumentation Systems | Equivalence between two argumentation systems means mainly that the two systems return the same outputs. It can be used for different purposes, namely in order to show whether two systems that are built over the same knowledge base but with distinct attack relations return the same outputs, and more importantly to check whether an infinite system can be reduced into a finite one.
Recently, the equivalence between abstract argumentation systems was investigated. Two categories of equivalence criteria were particularly proposed. The first category compares directly the outputs of the two systems (e.g. their extensions) while the second compares the outputs of their extended versions (i.e. the systems augmented by the same set of arguments). It was shown that only identical systems are equivalent w.r.t. those criteria.
In this paper, we study when two logic-based argumentation systems are equivalent. We refine existing criteria by considering the internal structure of arguments and propose new ones. Then, we identify cases where two systems are equivalent. In particular, we show that under some reasonable conditions on the logic underlying an argumentation system, the latter has an equivalent finite subsystem. This subsystem constitutes a threshold under which arguments of the system have not yet attained their final status and consequently adding a new argument may result in status change. From that threshold, the statuses of all arguments become stable. |
Tunneling Transistors Based on Graphene and 2-D Crystals | As conventional transistors become smaller and thinner in the quest for higher performance, a number of hurdles are encountered. The discovery of electronic-grade 2-D crystals has added a new “layer” to the list of conventional semiconductors used for transistors. This paper discusses the properties of 2-D crystals by comparing them with their 3-D counterparts. Their suitability for electronic devices is discussed. In particular, the use of graphene and other 2-D crystals for interband tunneling transistors is discussed for low-power logic applications. Since tunneling phenomenon in reduced dimensions is not conventionally covered in texts, the physics is developed explicitly before applying it to transistors. Though we are in an early stage of learning to design devices with 2-D crystals, they have already been the motivation behind a list of truly novel ideas. This paper reviews a number of such ideas. |
Constructing an Interactive Natural Language Interface for Relational Databases | Natural language has been the holy grail of query interface designers, but has generally been considered too hard to work with, except in limited specific circumstances. In this paper, we describe the architecture of an interactive natural language query interface for relational databases. Through a carefully limited interaction with the user, we are able to correctly interpret complex natural language queries, in a generic manner across a range of domains. By these means, a logically complex English language sentence is correctly translated into a SQL query, which may include aggregation, nesting, and various types of joins, among other things, and can be evaluated against an RDBMS. We have constructed a system, NaLIR (Natural Language Interface for Relational databases), embodying these ideas. Our experimental assessment, through user studies, demonstrates that NaLIR is good enough to be usable in practice: even naive users are able to specify quite complex ad-hoc queries. |
Cybercafés and their potential as Community Development Tools in India | Using public Internet facilities in order to access information and communication technologies (ICT) is the main model of use after the more common models of home use (individual ownership) and access at work or at school/university. Especially in developing countries, public and shared facilities help to create desperately needed access and are a main strategy in several Internet access programs. In the context of public access, cybercafes play an important role as the most common Internet access model, especially in the urban areas of India. It is often argued that cybercafes could help bridge the digital divide, as they provide Internet access to people who cannot afford to have Internet connections at their homes or who need help in order to make use of ICT. The following article will take this assumption as a starting point and will present findings from empirical research on cybercafes in urban India. The research was conducted in order to explore the problems and potential of cybercafes as development tools for different urban communities. In order to examine these relationships, the reach of cybercafes, the users of cybercafes and the usage patterns have been examined. This study is part of a doctoral thesis and the following article presents some of the findings. The article has to be seen as a preliminary report on ongoing research, and it presents some of the data collected to date in order to help build understanding concerning this complex access model and its importance for urban India. |
Bio-inspired self-healing structural color hydrogel. | Biologically inspired self-healing structural color hydrogels were developed by adding a glucose oxidase (GOX)- and catalase (CAT)-filled glutaraldehyde cross-linked BSA hydrogel into methacrylated gelatin (GelMA) inverse opal scaffolds. The composite hydrogel materials with the polymerized GelMA scaffold could maintain the stability of an inverse opal structure and its resultant structural colors, whereas the protein hydrogel filler could impart self-healing capability through the reversible covalent attachment of glutaraldehyde to lysine residues of BSA and enzyme additives. A series of unprecedented structural color materials could be created by assembling and healing the elements of the composite hydrogel. In addition, as both the GelMA and the protein hydrogels were derived from organisms, the composite materials presented high biocompatibility and plasticity. These features of self-healing structural color hydrogels make them excellent functional materials for different applications. |
The Infinity Computer and Numerical Computations with Infinite and Infinitesimal Numbers | A new methodology allowing one to execute numerical computations with finite, infinite, and infinitesimal numbers (see [7,9,15]) on a new type of a computer – the Infinity Computer – is introduced (see EU, USA, and Russian patents [8]). A calculator using the Infinity Computer technology is presented during the talk. The new approach is based on the principle ‘The part is less than the whole’ introduced by Ancient Greeks that is applied to all numbers (finite, infinite, and infinitesimal) and to all sets and processes (finite and infinite). It is shown that it becomes possible to write down finite, infinite, and infinitesimal numbers by a finite number of symbols as particular cases of a unique framework (different from that of the non-standard Analysis). The new methodology (see surveys [9,15]) evolves ideas of Cantor and Levi-Civita in a more applied way and (among other things) introduces infinite integers that possess both cardinal and ordinal properties as usual finite numbers (its relations with traditional approaches are discussed in [4,5,9,15]). Note that foundations of the Set Theory dealing with infinity have been developed starting from the end of the XIX-th century until more or less the first decades of the XX-th century. Foundations of the classical Analysis dealing both with infinity and infinitesimal quantities have been developed even earlier, more than 200 years ago, with the goal to develop mathematical tools allowing one to solve problems arising in the real world in that remote time. As a result, these parts of Mathematics reflect ideas that people had about Physics (including definitions of the notions continuous and discrete) more than 200 years ago. Thus, these mathematical tools do not include numerous achievements of Physics of the XX-th century. Even the brilliant non-standard Analysis of Robinson made |
Using Goffman ’ s Frameworks to Explain Presence and Reality | This paper defines presence in terms of frames and involvement [1]. The value of this analysis of presence is demonstrated by applying it to several issues that have been raised about presence: residual awareness of nonmediation, imaginary presence, presence as categorical or continuum, and presence breaks. The paper goes on to explore the relationship between presence and reality. Goffman introduced frames to try to answer the question, “Under what circumstances do we think things real?” Under frame analysis there are three different conditions under which things are considered unreal, these are explained and related to the experience of presence. Frame analysis is used to show why virtual environments are not usually considered to be part of reality, although the virtual spaces of phone interaction are considered real. The analysis also yields practical suggestions for extending presence within virtual environments. Keywords--presence, frames, virtual environments, mobile phones, Goffman. |
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