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41,811,600 | story | oliverchan2024 | 2024-10-11T17:51:12 | null | null | null | 1 | null | 41,811,600 | null | null | null | true |
41,811,601 | comment | xfalcox | 2024-10-11T17:51:21 | null | What about FP8? It is a target that is very popular for LLM inference. | null | null | 41,811,112 | 41,808,013 | null | [
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] | null | null |
41,811,602 | comment | alizaid | 2024-10-11T17:51:25 | null | Grokking is fascinating! It seems tied to how neural networks hit critical points in generalization. Could this concept also enhance efficiency in models dealing with non-linearly separable data? | null | null | 41,810,753 | 41,810,753 | null | [
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] | null | null |
41,811,603 | comment | rootusrootus | 2024-10-11T17:51:31 | null | I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common.<p>A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting.<p>The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I better skip at least one of those pieces of toast or I'm going to feel overfull and might get reflux as punishment.<p>But there are some unexpected positives.<p>Obviously I am eating less. I have to log food not to keep it in check, but to make sure I'm eating enough and with the right nutrients. There's another possible negative here -- you get a lot of hydration from food, so if you start eating less you should carefully monitor your fluid intake to allow for that.<p>But I'm also more focused. Not nearly as distracted. I'm getting a lot of things done which I used to just procrastinate on until years had passed in some cases. Man, the garage is going to be <i>clean</i> and superbly organized in a few weeks.<p>And my emotions are quieter. Not just the food noise, that was expected, but I feel more relaxed. That's not what I expected, and I'm pleasantly surprised.<p>As an aside, what makes this all really noticeable is that it's a once-a-week injection, and the peaks and valleys are <i>very</i> obvious. Saturday is injection day, but Sunday is where it <i>really</i> becomes quite noticeable that I took it. Monday-Wednesday is cruising altitude and the effects are good but not over the top. Thursday I can feel it tapering, and today ... well, I'm looking forward to tomorrow's injection. I might switch to a twice-a-week split dose at some point to ease the peaks and valleys.<p>Edit: Before someone asks, yes I have considered there may be long term effects. This is a risk, which I've decided I'm okay with at my age. Nobody gets to live forever anyway, and I was going to end up in an early grave via another route if I <i>didn't</i> do this. "Just eat less and exercise more" is trite. If it were <i>that</i> easy, we'd all be in fantastic shape.<p>I do hope to taper off at some point if I can figure out an alternate strategy for staying lighter. Though I'll miss some of the positive side-effects. | null | null | 41,811,263 | 41,811,263 | null | [
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41,811,604 | comment | null | 2024-10-11T17:51:32 | null | null | null | null | 41,811,558 | 41,811,263 | null | null | true | null |
41,811,605 | comment | null | 2024-10-11T17:51:32 | null | null | null | null | 41,810,128 | 41,799,068 | null | null | true | null |
41,811,606 | story | cheekyprogram | 2024-10-11T17:51:39 | Show HN: Add an Open AI assistant to your website easily | Hello all!<p>I have developed a system called My Cheeky Bot that allows you to add an OpenAI assistant to your website in minutes. You can either embed a sticky popup chat assistant to your site or inline an assistant to an existing page. I have developed scripts for existing page builders as well as a React package and a WordPress plugin to integrate your assistant effortlessly. It's free to try out. The main features are My Cheeky Bot will automatically collect leads from your conversations and also you can watch visitor conversations in real time to gain more insight. I am also going to be relying on a referral system to do my marketing. I appreciate all feedback! Thanks for taking a look! | https://www.mycheekybot.com | 1 | null | 41,811,606 | 0 | null | null | null |
41,811,607 | comment | zdragnar | 2024-10-11T17:51:45 | null | Statins have gone through several prescribing guideline revisions in the last 10-20 years. Many people were incorrectly prescribed them and some have suffered for it.<p>Likewise, there can be serious complications when taking GLP-1 agonists and the like. Since they need to be taken in perpetuity (many gain all weight lost upon stopping use) they should be reserved for only people who have exhausted all other opportunities.<p><i>Most</i> people over 65 should not be on statins. <i>Most</i> people should not be taking GPL-1 agonists. | null | null | 41,811,434 | 41,811,263 | null | [
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] | null | null |
41,811,608 | story | staplung | 2024-10-11T17:51:55 | Remains of Andrew "Sandy" Irvine Found on Everest | null | https://arstechnica.com/science/2024/10/remains-of-andrew-sandy-irvine-found-on-everest/ | 2 | null | 41,811,608 | 0 | null | null | null |
41,811,609 | comment | setgree | 2024-10-11T17:52:01 | null | There's some evidence that Ozempic improves general impulse control, e.g decreasing alcohol consumption [0], which the article mentions.<p>Also, as Tyler Cowen writes [1], this is probably going to translate into big improvements for animal welfare:<p>> People lose weight on these drugs because they eat less, and eating less usually means eating less meat. And less meat consumption results in less factory farming. This should count as a major victory for animal welfare advocates, even though it did not come about through their efforts. No one had to be converted to vegetarianism, and since these drugs offer other benefits, this change in the equilibrium is self-sustaining and likely to grow considerably.<p>So overall, widespread Ozempic adoption seems like progress to me.<p>[0] <a href="https://www.npr.org/sections/health-shots/2023/08/28/1194526119/ozempic-wegovy-drinking-alcohol-cravings-semaglutide" rel="nofollow">https://www.npr.org/sections/health-shots/2023/08/28/1194526...</a><p>[1] <a href="https://www.bloomberg.com/opinion/articles/2024-07-20/animal-welfare-is-improving-no-thanks-to-activists" rel="nofollow">https://www.bloomberg.com/opinion/articles/2024-07-20/animal...</a> | null | null | 41,811,263 | 41,811,263 | null | [
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41,811,610 | comment | gadflyinyoureye | 2024-10-11T17:52:05 | null | Only in the US. Other countries are like 90% less expensive. However, Medicare might try to get better deal since the next round of deal making can include it since the drug is 7 years old.<p><a href="https://slate.com/technology/2023/07/ozempic-costs-a-lot-it-doesnt-have-to.html" rel="nofollow">https://slate.com/technology/2023/07/ozempic-costs-a-lot-it-...</a> | null | null | 41,811,567 | 41,811,263 | null | null | null | null |
41,811,611 | comment | habitue | 2024-10-11T17:52:08 | null | Seems like just an orthogonal problem? If calorie input is solved, now all the moralizing and shaming can be about nutrition instead | null | null | 41,811,558 | 41,811,263 | null | [
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] | null | null |
41,811,612 | comment | yumraj | 2024-10-11T17:52:23 | null | Can it use GPU if available, say on Apple silicon Macs | null | null | 41,810,695 | 41,773,020 | null | [
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] | null | null |
41,811,613 | comment | istjohn | 2024-10-11T17:52:23 | null | This discussion proves the importance. We are so far from properly appreciating the horror of nuclear weapons. One would think that after nearly eighty years Americans would be able to apprehend our crimes against the innocents of Hiroshima and Nagasaki with clear vision. | null | null | 41,809,706 | 41,807,681 | null | null | null | null |
41,811,614 | comment | hinkley | 2024-10-11T17:52:24 | null | Gretchen! Stop trying to make Lisp happen. It’s not going to happen. | null | null | 41,808,696 | 41,808,696 | null | null | null | null |
41,811,615 | comment | wtetzner | 2024-10-11T17:52:28 | null | > They are simply extreme lock-in proponents and don't want to support cross platform graphics API.<p>Which seems like an ineffective move when you have no market share. | null | null | 41,811,346 | 41,799,068 | null | [
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] | null | null |
41,811,616 | comment | aleksiy123 | 2024-10-11T17:52:30 | null | How effective is it? | null | null | 41,811,596 | 41,811,263 | null | null | null | null |
41,811,617 | comment | indiebat | 2024-10-11T17:52:44 | null | I don’t want this to come out insensitive or from under the rock, but why is taking a drug a novel & cool idea (all of a sudden/recently) as opposed to good old fashioned working out and not eating more than what you need? okay, this drug is all kinds of great and it’s the next best thing since green grapes, still not eating more and workout is better than taking drugs that effect your brain right? Are doctors required to explain this before prescribing this in US? | null | null | 41,811,263 | 41,811,263 | null | [
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41,811,618 | comment | khuey | 2024-10-11T17:52:51 | null | Japan is free to withdraw from the NPT at any time. | null | null | 41,811,419 | 41,807,681 | null | null | null | null |
41,811,619 | comment | iamsanteri | 2024-10-11T17:52:59 | null | Right exactly, so GitOps doesn't necessarily mean that after merging the pull request, the rest HAS to happen automatically? Judging by what you say there's indeed some ambiguity here in that sense. I guess after I hear "GitOps" being mentioned, I'll have to ask for details and dig in more to understand what people actually mean by that, haha. At least there will probably be Git there somewhere and the infrastructure is version controlled then I guess... | null | null | 41,811,055 | 41,810,998 | null | null | null | null |
41,811,620 | comment | asib | 2024-10-11T17:53:11 | null | Sure, but the "unhealthy but not excessively caloric" diet is not a problem ozempic attempts to address. As far as I understand, it simply limits your appetite. Potentially one can go on ozempic, lose weight, and still end up eating unhealthily, because the resulting diet is made up of nutritionally poor foods. | null | null | 41,811,558 | 41,811,263 | null | [
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41,811,621 | comment | dang | 2024-10-11T17:53:14 | null | We detached this subthread from <a href="https://news.ycombinator.com/item?id=41802586">https://news.ycombinator.com/item?id=41802586</a>. Not a criticism—it just went pretty far off topic. | null | null | 41,805,001 | 41,799,068 | null | null | null | null |
41,811,622 | comment | Arrath | 2024-10-11T17:53:17 | null | Oh I can imagine it happening. I'm currently working in Pearl Harbor and find myself hoping that I'll be on-base if the balloon goes up, thus avoiding any post-apocalyptic survival bullshit in a brilliant flash. | null | null | 41,811,546 | 41,807,681 | null | null | null | null |
41,811,623 | comment | amatecha | 2024-10-11T17:53:22 | null | This article seems to frame things in such a strange way. Maybe instead of trying to get everyone obesity medication, we can instead educate society so we all understand nutrition and diet and can combat the ever-persistent forces of corporations pushing unhealthy food on us? | null | null | 41,811,263 | 41,811,263 | null | [
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41,811,624 | comment | superb_dev | 2024-10-11T17:53:36 | null | That doesn’t make sense in the context | null | null | 41,811,122 | 41,809,879 | null | null | null | null |
41,811,625 | comment | carabiner | 2024-10-11T17:53:37 | null | Next up is maybe ozempic. | null | null | 41,811,397 | 41,753,677 | null | null | null | null |
41,811,626 | comment | wizzwizz4 | 2024-10-11T17:53:48 | null | Source? <a href="https://www.mcgill.ca/oss/article/medical-critical-thinking/berberine-dont-swallow-hype-or-pill" rel="nofollow">https://www.mcgill.ca/oss/article/medical-critical-thinking/...</a> (2023) disagrees with you:<p>> Neither is berberine any version of Ozempic, which is an analogue of glucagon-like-peptide-1 (GLP-1), a natural hormone that regulates blood sugar and helps people feel full. Berberine has nothing to do with GLP-1.<p>> Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is the control that berberine may exert over blood sugar. But there is a problem. Berberine is virtually insoluble in water and has low intestinal absorption which means it has poor bioavailability. […] Because of berberine’s poor bioavailability, supplements on the market are likely to be useless. However, some derivative of berberine, may yet make it to the physician’s prescription pad. But it won’t be for weight loss. | null | null | 41,811,596 | 41,811,263 | null | [
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] | null | null |
41,811,627 | comment | btilly | 2024-10-11T17:53:54 | null | Thank you for the compliment.<p>I've been working on how to formulate that idea clearly for a while. It is a problem that goes well beyond physics. For example I believe that the same cognitive error is behind the fact that experts do significantly worse than chance in actually predicting the world, and the more certain the expert sounds, the less likely they are to be right. See <a href="https://www.amazon.com/Expert-Political-Judgment-Good-Know/dp/0691128715" rel="nofollow">https://www.amazon.com/Expert-Political-Judgment-Good-Know/d...</a> for data demonstrating that fact.<p>Depressingly, this means that we consistently put public policy in the hands of people who are demonstrably incompetent. | null | null | 41,811,306 | 41,808,127 | null | [
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] | null | null |
41,811,628 | comment | rozenmd | 2024-10-11T17:53:55 | null | Uptime monitors ping your server, this seems to do the opposite. | null | null | 41,811,332 | 41,809,879 | null | null | null | null |
41,811,629 | comment | null | 2024-10-11T17:53:55 | null | null | null | null | 41,811,617 | 41,811,263 | null | null | true | null |
41,811,630 | comment | Nathans220 | 2024-10-11T17:54:07 | null | yes | null | null | 41,793,070 | 41,792,500 | null | null | null | null |
41,811,631 | story | jitl | 2024-10-11T17:54:16 | Wat: JavaScript lighting talk (2012) [video] | null | null | 1 | null | 41,811,631 | 0 | null | null | null |
41,811,632 | comment | ignoramous | 2024-10-11T17:54:39 | null | <a href="https://en.wikipedia.org/wiki/Dirty_bomb" rel="nofollow">https://en.wikipedia.org/wiki/Dirty_bomb</a> | null | null | 41,808,103 | 41,807,681 | null | [
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] | null | null |
41,811,633 | comment | mike_hearn | 2024-10-11T17:54:47 | null | Corbyn was famous for organizing large rallies, if anything this was a criticism of him - he was much more interested in rallies and protests than leadership.<p>Pictures of Corbyn in front of huge crowds at rallies:<p><a href="https://labourlist.org/2019/08/corbyn-encourages-labour-mps-to-join-rallies-against-shutdown/" rel="nofollow">https://labourlist.org/2019/08/corbyn-encourages-labour-mps-...</a><p><a href="https://www.counterfire.org/article/letter-left-corbyn-labour-gloves-off-time-to-fight/" rel="nofollow">https://www.counterfire.org/article/letter-left-corbyn-labou...</a><p><a href="https://socialistworker.co.uk/news/thousands-rally-for-jeremy-corbyn-as-labour-mps-try-and-force-him-out/" rel="nofollow">https://socialistworker.co.uk/news/thousands-rally-for-jerem...</a> | null | null | 41,805,531 | 41,804,460 | null | null | null | null |
41,811,634 | comment | apsec112 | 2024-10-11T17:54:49 | null | Saying that the cure for obesity is to eat less is like saying that the cure for heroin addiction is to stop using heroin. It's both clearly true, and also useless. | null | null | 41,811,617 | 41,811,263 | null | [
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] | null | null |
41,811,635 | comment | randomdata | 2024-10-11T17:54:51 | null | <i>> Go also does not do any sort of "advanced" devirtualization</i><p>Depends on the implementation. gc doesn't put a whole lot of effort into optimization, but it isn't the only implementation. In fact, the Go project insists that there must be more than one implementation as part of its mandate. | null | null | 41,809,456 | 41,787,041 | null | [
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] | null | null |
41,811,636 | comment | Hammershaft | 2024-10-11T17:54:52 | null | Interdependence via global trade makes it unlikely that without nuclear weapons we would have nearly the number of wars we had in the 1940s. | null | null | 41,811,074 | 41,807,681 | null | [
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] | null | null |
41,811,637 | comment | daft_pink | 2024-10-11T17:55:03 | null | Yup. Awesome! Thanks! | null | null | 41,796,273 | 41,789,551 | null | null | null | null |
41,811,638 | comment | birdman3131 | 2024-10-11T17:55:06 | null | At no point are they saying tesla's are bad. Just that they are not good for what police need them to do.<p>I have no connection to police but I do own a 2015 ford Police Interceptor Utility (Essentially an explorer.)<p>There are several features that are useful to police.<p>Manual headlights. (Keep debating spending the ~$50-70 to upgrade to auto headlights.) The lights and horn do not trigger when you lock the car with the remote. Nor do lights come on when you open the door. (All of these are features to prevent drawing attention when you are idling on the side of the road.)<p>Fairly tall sidewalls. I can go over a curb and not have any issue. The suspension is the best of any car / truck I have owned.<p>It is rated for a 75MPH impact from the rear. (Fun fact. The full size spare tire is required to be in place to keep the rating.<p>I have 4 switches on the steering wheel for accessories. (I assume stuff like lights and sirens.)<p>There are some others like being able to disconnect the door locks from the back doors although mine were set to normal car when I got it. | null | null | 41,810,627 | 41,810,627 | null | null | null | null |
41,811,639 | comment | ibraheemdev | 2024-10-11T17:55:09 | null | It's quite common for concurrent algorithms to only implement a subset of operations. For example forgoing, removal or iteration. It's also common to put limitations on the data structure, such as limiting keys and values to 64-bits. Papaya being feature-complete means that it does not have any of these limitations when compared to std::collections::HashMap. | null | null | 41,809,676 | 41,798,475 | null | null | null | null |
41,811,640 | comment | null | 2024-10-11T17:55:10 | null | null | null | null | 41,811,596 | 41,811,263 | null | null | true | null |
41,811,641 | story | alizaid | 2024-10-11T17:55:10 | Show HN: Bazaari – An Easy Simple Ecommerce Platform | null | https://bazaari.io/ | 2 | null | 41,811,641 | 2 | [
41811664,
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] | null | null |
41,811,642 | comment | popcalc | 2024-10-11T17:55:20 | null | AAPL and MSFT create value for their customers.<p>>Value is what we assign to something collectively. It’s not a measure of some intrinsic reality.<p>I beg to differ. | null | null | 41,809,752 | 41,802,823 | null | [
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] | null | null |
41,811,643 | story | handfuloflight | 2024-10-11T17:55:24 | Hamming: Voice Agent Tooling | null | https://hamming.ai/ | 1 | null | 41,811,643 | 0 | null | null | null |
41,811,644 | comment | archagon | 2024-10-11T17:55:30 | null | I find it bizarre how many people are still discussing American politics as if there remain two sensible and balanced political parties in play. Unfortunately, we do not have that anymore. We have a coalition liberal/conservative Democratic party and a far-right Republican party that has driven straight off a cliff. One of the candidates for president is a vile, stupid, deeply corrupt rapist who literally tried to overturn the last election and now wants to be “dictator for a day,” while his closest allies[1] are radical ethno-nationalists who want to install an authoritarian state with 19th century cultural trimmings. Every other word these people speak is an unambiguous lie in service of riling up their base and accruing power. Candidates like McCain and Palin are but a blip in the rear view mirror.<p>At this point, I only have the energy to gawk in horror at the unfolding situation: discussing the minutiae of policy feels almost comical when the very soul of the country is at stake. Never could I imagine how much blatantly obvious evil could be laundered through the intrinsic balance fallacy of a two-party system.<p>[1]: <a href="https://www.newsweek.com/donald-trump-says-project-2025-author-coming-onboard-if-elected-1966334" rel="nofollow">https://www.newsweek.com/donald-trump-says-project-2025-auth...</a> | null | null | 41,804,460 | 41,804,460 | null | null | null | null |
41,811,645 | comment | danudey | 2024-10-11T17:55:42 | null | > Why don't we try to induce demand on public transit? Make it cheaper, subsidize it like we subsidize roads/parking, add additional routes.<p>Good systems do; most systems don't, for lots of reasons.<p>1. Public transit is for poor people, and poor people don't fund re-election campaigns<p>2. Subsidizing public transit is spending the public's money, and the public has spent decades being told that "socialism" is going to take away their freedom and choice; in this case, the government is going to put more of YOUR tax dollars into public transit and then TAKE AWAY your cars.<p>It becomes a vicious cycle:<p>1. Transit is under-funded (or the funding is maintained but not increased to match rising ridership and costs)<p>2. Service has to get cut in areas with low ridership (e.g. areas with a lot of retirement communities get cuts to route frequency)<p>3. People get mad because now their buses run less often so they have to leave earlier or later than they wanted to<p>4. Why are we paying these people when they're just giving us worse and worse service?<p>In the end you wind up with a scenario where people are voting no to additional transit funding, and pointing to the direct results of under-funding as their explanation - look how bad service is, why would we give them more money? [0]<p>[0] <a href="https://www.cbc.ca/news/canada/british-columbia/transit-referendum-voters-say-no-to-new-metro-vancouver-tax-transit-improvements-1.3134857" rel="nofollow">https://www.cbc.ca/news/canada/british-columbia/transit-refe...</a> | null | null | 41,803,208 | 41,797,719 | null | null | null | null |
41,811,646 | story | mr-marbo | 2024-10-11T17:55:43 | Why Tesla's EV Charging System Won the Race to Become America's Standard | null | https://www.motortrend.com/features/tesla-nacs-charge-cable-standard-sae-j3400/ | 15 | null | 41,811,646 | 5 | [
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41,811,647 | comment | null | 2024-10-11T17:55:54 | null | null | null | null | 41,805,588 | 41,804,460 | null | null | true | null |
41,811,648 | comment | whatshisface | 2024-10-11T17:55:57 | null | Chinese troops and Soviet planes were there in Korea. | null | null | 41,809,721 | 41,807,681 | null | null | null | null |
41,811,649 | comment | brianbrown | 2024-10-11T17:56:08 | null | Both, the EPA and the EFSA estimates, are incorrect. One standard cup of Asian organic green tea (6 oz - 177 ml) may contain 1.20 mg of fluoride.<p><a href="https://poisonfluoride.com/phpBB3/viewtopic.php?f=11&t=5677" rel="nofollow">https://poisonfluoride.com/phpBB3/viewtopic.php?f=11&t=5677</a><p>The NTP monograph is a very flawed document, as the review failed to consider a crucial confounder/modifier - iodine/thyroid status. Fluoride toxicity is directly dependent on the individual's thyroid/iodine status. If iodine-deficient, even miniscule amounts of fluoride may affect you. If iodine intake is excessive, then iodine toxicity may be pre-dominant - this has been known since the 1930s.<p>See <a href="https://pfpc.substack.com/p/pfpc-letter-to-richard-woychik-director" rel="nofollow">https://pfpc.substack.com/p/pfpc-letter-to-richard-woychik-d...</a> | null | null | 41,799,881 | 41,757,346 | null | null | null | null |
41,811,650 | comment | epcoa | 2024-10-11T17:56:18 | null | > I was familiar with Ada, but I wasn't aware that it had an ownership system like Rust that could guarantee memory safety.<p>The point for bringing up Ada was more that a non-academic "memory-safe" language without GC existed for decades (predating Linux). Old school Ada doesn't use the ownership system, and true doesn't give all the compile-time safety guarantees of Rust but it does give some (and rust in practice cant't either, run the output of grep unsafe | wc on the linux/rust source tree), it also provides some affordances lacking in safe rust. Memory-safety is not some binary or univariate concept that you seem somewhat close to implying.
You could have written Linux in Ada from day one and been "safer" than C (imagine that universe).<p>Related:<p><a href="https://pling.jondgoodwin.com/post/cyclone/" rel="nofollow">https://pling.jondgoodwin.com/post/cyclone/</a> (which is also referred to in the aforementioned paper).<p>> I think that's enough to demonstrate that Rust's ownership system is substantially novel<p>Well, where did anyone say it wasn't, but it certainly wasn't novel in pushing safety as a first class concept for a low level systems language. The fact that it is as (deservedly) successful as it is must be due to other factors.
I'm not saying Ada did it first as some kind of gotcha, but Ada did it first and it does not rule the world.<p>Also, interesting comments from the creator of Rust.<p><a href="https://www.reddit.com/r/rust/comments/t9972l/comment/hztbsni" rel="nofollow">https://www.reddit.com/r/rust/comments/t9972l/comment/hztbsn...</a><p><a href="https://www.reddit.com/r/rust/comments/le7m54/comment/gmb4zgc" rel="nofollow">https://www.reddit.com/r/rust/comments/le7m54/comment/gmb4zg...</a><p>I'll reiterate, I'm very pro-Rust. I'm just old and look at the current governance and state of corporate involvement and it gives me flashbacks to commercial Unix in the late 80s/early 90s. IIn any case, I think fetishizing the borrow checker or a specific PL feature as having much to with its success (or failure) is sort of irrelevant. | null | null | 41,809,717 | 41,766,293 | null | null | null | null |
41,811,651 | comment | jasongill | 2024-10-11T17:56:22 | null | I actually won one of the 50 floppy copies of "Having a Blast"! If you send me an email at my HN username @gmail.com I'll send you a copy once I get it and rip it. | null | null | 41,796,255 | 41,790,295 | null | null | null | null |
41,811,652 | comment | Hammershaft | 2024-10-11T17:56:34 | null | BRICS? What ideological war is South Africa, India, and Brazil waging against the west? Members of Brics such as India and China are closer to war with each other then they are to war with the West. | null | null | 41,809,311 | 41,807,681 | null | null | null | null |
41,811,653 | comment | kelseyfrog | 2024-10-11T17:56:37 | null | From my understanding GLP-1 agonists can actually modulate the reward pathway reducing people's appetite for toxic diets.<p>We're not socially caught up yet to this information. I suspect there are folks who believe that regardless of similar outcome (reduction of toxic diet), that changing diet without medication is superior to those who change their behavior through pharmacological intervention. It's like the pre-1990s view on depression or anxiety - chemical intervention is a moral weakness. | null | null | 41,811,558 | 41,811,263 | null | [
41812166,
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] | null | null |
41,811,654 | comment | MBCook | 2024-10-11T17:56:42 | null | No, but if it helps avoid the discussion because the very visible side effect is lessened, then in some ways things are worse. No squeaky wheel.<p>I’m glad it’s available for those who need it. But I agree with GP that there is another discussion we need to be having too we’ve avoided for far far too long. | null | null | 41,811,620 | 41,811,263 | null | [
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] | null | null |
41,811,655 | comment | hombre_fatal | 2024-10-11T17:56:46 | null | What about compounding pharmacies like Hims.com? It's $400/mo month to month but $200/mo if you pay a year upfront. | null | null | 41,811,567 | 41,811,263 | null | [
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] | null | null |
41,811,656 | comment | wumeow | 2024-10-11T17:56:47 | null | > Since January, there have been 77 incidents in which Taiwanese have gone missing in mainland China, often in cases involving fraud allegations, according to Luo Wen-jia, secretary general of the Straits Exchange Foundation, a semiofficial organization in Taiwan that handles relations with mainland China | null | null | 41,811,372 | 41,811,372 | null | null | null | null |
41,811,657 | comment | shmerl | 2024-10-11T17:56:51 | null | They don't seem to care. I'm sure that will bite them in the long term, but for now they are very intent on complete NIH and lock-in anywhere they can push it. | null | null | 41,811,615 | 41,799,068 | null | null | null | null |
41,811,658 | comment | tamperedtomato | 2024-10-11T17:56:51 | null | [dead] | null | null | 41,808,723 | 41,808,723 | null | null | null | true |
41,811,659 | comment | oliwarner | 2024-10-11T17:56:53 | null | First, the quote talks about what I do privately. AGPL explicitly encourages me to do whatever the hell I like with it. I don't need another license.<p>But broader, the interpretation that AGPL microservices are viral is just one interpretation. If it really is just a swappable backend interface, why should it affect other subsystems? IANAL but it seems pretty trivial to insulate a microservice with the same sort of GPL condom companies ship to avoid "linking" to (eg) the Kernel.<p><a href="https://medium.com/swlh/understanding-the-agpl-the-most-misunderstood-license-86fd1fe91275" rel="nofollow">https://medium.com/swlh/understanding-the-agpl-the-most-misu...</a> | null | null | 41,811,040 | 41,804,341 | null | null | null | null |
41,811,660 | story | PaulHoule | 2024-10-11T17:57:07 | Fine-Tuning Vision Classifiers on a Budget | null | https://arxiv.org/abs/2410.00085 | 1 | null | 41,811,660 | 0 | null | null | null |
41,811,661 | comment | winterrx | 2024-10-11T17:57:15 | null | David Friedberg recently did an All-In Interview with the CEO of Eli Lilly. Interesting conversation over there that also talked about some key points of the article.<p><a href="https://www.youtube.com/watch?v=023exhA9irY" rel="nofollow">https://www.youtube.com/watch?v=023exhA9irY</a> | null | null | 41,811,263 | 41,811,263 | null | null | null | null |
41,811,662 | comment | BoingBoomTschak | 2024-10-11T17:57:20 | null | Well, the negative consequence on the value of willpower is pretty obvious. "In what measure" is the real question. | null | null | 41,811,539 | 41,811,263 | null | [
41811912,
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] | null | null |
41,811,663 | comment | giantg2 | 2024-10-11T17:57:21 | null | And the argument you are replying to is that it's just covering up a symptom and not addressing the root problem holistically. Ozempic isn't a fix, it's a bandaid. | null | null | 41,811,620 | 41,811,263 | null | [
41812135,
41811695,
41811993,
41811720
] | null | null |
41,811,664 | comment | alizaid | 2024-10-11T17:57:25 | null | Bazaari.io is the easiest way for sellers to create and launch their online stores.<p>It's a platform built for sellers with features like:
• Free Store with SEO optimization
• Effortless product listing
• Custom action button
• Personalized links to share with your customers<p>I am also adding new features like:
• Selling digital products
• Analytics Like Plausible
• Marketplace
• Brand Your Store<p>And the best part? Bazaari.io is free for a limited time.<p>Don't miss the chance to create your online store today! | null | null | 41,811,641 | 41,811,641 | null | null | null | null |
41,811,665 | comment | taylodl | 2024-10-11T17:57:51 | null | The author is confusing "toxic masculinity" with "masculinity."<p>Posing their question another way - why aren't we talking about why there's been a rise in toxic masculinity, since that is a big factor in explaining why fewer men are going to college? | null | null | 41,811,050 | 41,811,050 | null | [
41811769
] | null | null |
41,811,666 | comment | Karrot_Kream | 2024-10-11T17:57:55 | null | There's a decent amount of evidence that the most toxic thing about modern diets is their amounts: calorie counts and such. Many things (sugars, ultra-processed foods (ugh I hate the NOVA classification), fat, etc) are fine in moderation. The dose makes the poison. | null | null | 41,811,558 | 41,811,263 | null | null | null | null |
41,811,667 | comment | codingdave | 2024-10-11T17:57:57 | null | Because not everyone has willpower and discipline. People who do have those strengths often think it is just as simple as saying, "Just take care of yourself", but it is not that easy for many people. High blood sugar also increases cravings, which makes it even harder, bringing on a downward spiral.<p>This drug can help break out of that spiral and fix the craving/willpower problems. | null | null | 41,811,617 | 41,811,263 | null | [
41811907,
41812024,
41811814,
41811848
] | null | null |
41,811,668 | comment | ants_everywhere | 2024-10-11T17:58:01 | null | My understanding of the situation (which may be wrong, in which case please let me know) is that physics is stuck at a local optimum.<p>There are two obvious ways to get out<p>(1) Surprising physical observations, or<p>(2) Mathematical advances<p>Way (1) is what kicked off quantum mechanics. Way (2) is what kicked off Newtonian mechanics.<p>I see string theorists and loop quantum gravity people as working on (2). Their models are mathematically interesting and aren't totally understood from a mathematical perspective. But they're different enough that studying them may break the impasse.<p>I see (1) as largely limited by the budgets and technology needed to build things like particle accelerators and spacecraft.<p>For (2) you have to decide whether to only explore mathematics that defines physical reality, or whether to also allow exploration of non-physical systems. For example, you might explore a universe that is almost physical but has time machines. Restricting the search space to only physically realistic systems is a significant constraint, so there's a debate to be be had about how much weight to give it. | null | null | 41,808,127 | 41,808,127 | null | [
41812547,
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] | null | null |
41,811,669 | comment | andrewmcwatters | 2024-10-11T17:58:06 | null | You can literally do the same thing by eating a healthy diet for 2-4 weeks. | null | null | 41,811,653 | 41,811,263 | null | [
41811701,
41812207,
41811731,
41812976,
41811891
] | null | null |
41,811,670 | story | eloisai | 2024-10-11T17:58:08 | Brushless AI | null | https://www.brushless.ai/ | 1 | null | 41,811,670 | 0 | [
41811671
] | null | null |
41,811,671 | comment | null | 2024-10-11T17:58:08 | null | null | null | null | 41,811,670 | 41,811,670 | null | null | true | null |
41,811,672 | comment | mike_hearn | 2024-10-11T17:58:12 | null | Which state is that? I thought the strictest laws at the moment were in Alabama, which does allow abortions in the case of a serious risk to the mother's life. | null | null | 41,809,384 | 41,804,460 | null | null | null | null |
41,811,673 | story | Tomte | 2024-10-11T17:58:16 | Fast Unicode (UTF-8) validation (2020) | null | https://lemire.me/blog/2020/10/20/ridiculously-fast-unicode-utf-8-validation/ | 2 | null | 41,811,673 | 0 | null | null | null |
41,811,674 | comment | wakawaka28 | 2024-10-11T17:58:18 | null | >No it doesn't, unless you're going to somehow limit the # of "tokens" per human, which seems to me to be impossible if the goal here is anonynimity.<p>The intent is not to limit the number of tokens per human. The intent is to establish confidence that an account is real by allowing tokens to be associated with it. Additionally, the system would do well to have a database of all accounts associated with a single token. If someone wants to have 10 accounts with 10 separate tokens, that is fine. At least you know it's probably not a bot farm running thousands of fake accounts, because nobody could afford it.<p>>You and OP seem to assume that driving the cost up will scale the cost of an attack at the same rate - it won't. These actors will just commit more crimes in order to acquire more "tokens" - either phishing/hacking them, or stealing from distributors, or...<p>Increasing cost does limit the scale of attacks. You might as well be saying that the high price of drugs is not a limit to the scale of drug abuse because people will steal them lol. Committing more crimes is not free of cost. It requires time, opportunity, and expertise. I think a system like I have described can be used to track the tokens and prevent abuse, while allowing people to obtain them anonymously. Every crime committed adds a trail of evidence that can be used to uncover abuse.<p>>At the same time, you'll be making it difficult/impossible for poor people to access the Internet freely, further widening income and class inequality both on the Internet and likely in reality too.<p>No, that is all BS. All this means is that they may have to pay more to be anonymous. People of all social classes already have to pay more for guaranteed anonymity, whether it be through buying additional devices, VPN subscriptions, or travel costs as they go to Internet cafes. If you are poor, you still have the option of being less anonymous. We're talking about being provably anonymous here and instilling confidence in one being a real person here, which is a distinctly different problem from being online in general. | null | null | 41,806,529 | 41,794,517 | null | [
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] | null | null |
41,811,675 | comment | xvedejas | 2024-10-11T17:58:25 | null | Most people don't work out enough, or don't eat well enough. If we had some kind of intervention that would easily cause people to work out, we would use that intervention. If we had some kind of intervention that would easily cause people to eat well, we would use that intervention. The reason working out and good diet are good is because of good health outcomes. If we have some kind of intervention that skips straight to the good health outcomes, we would use that intervention. It seems like Ozempic is _that_ intervention, so we will use it. I will likely choose Ozempic for myself once it is available to me. | null | null | 41,811,617 | 41,811,263 | null | null | null | null |
41,811,676 | comment | cynicalpeace | 2024-10-11T17:58:30 | null | Hilariously, Trump effectively legalized marijuana accidentally in the 2018 Farm bill. <a href="https://thehill.com/homenews/4564181-2018-farm-bill-hemp-cannabis-attorneys-general/" rel="nofollow">https://thehill.com/homenews/4564181-2018-farm-bill-hemp-can...</a> | null | null | 41,809,982 | 41,807,681 | null | null | null | null |
41,811,677 | comment | gedy | 2024-10-11T17:58:30 | null | Keep in mind a lot of people who'd benefit from this may not last another 30 years due to age or health issues due to weight either. | null | null | 41,811,539 | 41,811,263 | null | [
41812013,
41812061
] | null | null |
41,811,678 | comment | philipkglass | 2024-10-11T17:58:31 | null | Interesting.<p>"Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways"<p><a href="https://www.sciencedirect.com/science/article/pii/S0006295215003822" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S000629521...</a><p>But buyer beware when it comes to getting berberine from over-the-counter supplements:<p>"Variability in Potency Among Commercial Preparations of Berberine"<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807210/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807210/</a><p><i>Nine of the 15 tested products (60%) failed to meet the potency standards of 90% to 110% of labeled content claim, as commonly required of pharmaceutical preparations by the U.S. Pharmacopeial Convention. Evaluation of the relationship between product cost and the measured potency failed to demonstrate an association between quality and cost. Variability in product quality may significantly contribute to inconsistencies in the safety and effectiveness of berberine. In addition, the quality of the berberine product cannot be inferred from its cost.</i><p>Worse still,<p>"Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability"<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337101/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337101/</a><p><i>Berberine—an isoquinoline alkaloid isolated from the rhizome of Coptidis rhizome, Cortex phellodendri, and other plant species—possesses a variety of pharmacological effects, including anti-cancer, anti-hyperglycemic, anti-hyperlipidemic, antimicrobial, anti-inflammatory, and antioxidant activities. However, its absolute bioavailability is as low as 0.68%. Low bioavailability greatly restricts the clinical development of berberine.</i> | null | null | 41,811,596 | 41,811,263 | null | null | null | null |
41,811,679 | comment | acegopher | 2024-10-11T17:58:40 | null | The same could be said of the ARM Cortex-M0+. | null | null | 41,809,593 | 41,808,696 | null | [
41811775
] | null | null |
41,811,680 | comment | tredre3 | 2024-10-11T17:58:45 | null | > big improvements for animal welfare<p>Is it? It might reduce the amount of animals killed, sure, but it won't improve the well-being of the ones that are still raised. | null | null | 41,811,609 | 41,811,263 | null | [
41811753,
41811750,
41811719,
41811732,
41812055
] | null | null |
41,811,681 | story | ck2 | 2024-10-11T17:58:48 | Comet Tsuchinshan-Atlas approaches Earth Saturday, won't be back for 80000 years | null | https://www.cnn.com/2024/10/09/science/comet-tsuchinshan-atlas-earth/index.html | 1 | null | 41,811,681 | 1 | [
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] | null | null |
41,811,682 | comment | Fernicia | 2024-10-11T17:58:51 | null | Is it fundamentally any different from something like toothpaste?<p>Humans have created a technology (mechanised farming) with a side effect we haven't yet evolved to handle (an abundance of tasty calories), so it doesn't seem all that strange we would fix it with a technology (inhibiting the desire for said calories). | null | null | 41,811,558 | 41,811,263 | null | null | null | null |
41,811,683 | story | captbaritone | 2024-10-11T17:58:52 | No-unused-binary-expressions: From code review nit to ecosystem improvements | null | https://eslint.org/blog/2024/10/code-review-nit-to-ecosystem-improvements/ | 3 | null | 41,811,683 | 0 | null | null | null |
41,811,684 | comment | imbnwa | 2024-10-11T17:58:54 | null | Why is this thread not on the first 4 or 5 pages of HN? | null | null | 41,809,698 | 41,809,698 | null | [
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] | null | null |
41,811,685 | comment | blocko | 2024-10-11T17:59:07 | null | What is the rationale behind the following?<p>> When comparing password hashes, use constant time comparison instead of ==.<p>If you were comparing plaintext you'd get some info, but it seems overly cautious when comparing salted hashes. Maybe anticipating an unknown vulnerability in the hash function? | null | null | 41,801,883 | 41,801,883 | null | null | null | null |
41,811,686 | comment | dr_dshiv | 2024-10-11T17:59:33 | null | My understanding is that, if you train these enough, it becomes likely to develop efficient compressions— which “reasoning” would be. | null | null | 41,809,529 | 41,808,683 | null | null | null | null |
41,811,687 | comment | lostmsu | 2024-10-11T17:59:33 | null | I think your statement is very funny. If the drug keeps weight in check on a toxic diet and that has the same outcome as "healthy life", then is that "healthy life" any more healthy then the drug+junkfood combo? Also, what is sad about it? | null | null | 41,811,558 | 41,811,263 | null | null | null | null |
41,811,688 | comment | zonkerdonker | 2024-10-11T17:59:53 | null | I was able to find this: <a href="https://www.sciencedirect.com/science/article/abs/pii/S0006295215003822#:~:text=The%20present%20results%20demonstrated%20that,taste%20substance%20obtain%20hypoglycemic%20effect" rel="nofollow">https://www.sciencedirect.com/science/article/abs/pii/S00062...</a>.<p>Apparently most of the effect is due to activation of the "bitter taste reception pathways" in the gut. So even though it has very low bioavailibility, it can still stimulate GLP-1 secretion just simply due to its incredible bitterness | null | null | 41,811,626 | 41,811,263 | null | null | null | null |
41,811,689 | comment | gedy | 2024-10-11T17:59:54 | null | Look we've been educating people about this for the past 50 years at least - education doesn't work with base impulses. | null | null | 41,811,623 | 41,811,263 | null | null | null | null |
41,811,690 | comment | tmtvl | 2024-10-11T18:00:08 | null | > <i>Network services are defined by the presence, in a directory watched by listen, of executable files whose name is of the form <protocol><port>.</i><p>That seems a bit silly to me as it means something like <i>rot1376</i> is tricky to parse correctly. I'd think it would make sense for the protocol to need to be separated from the port by a non-numeric character, like a hyphen. Like that it would be trivial to parse: just grab all the numeric characters from the end until we find the non-numeric character. | null | null | 41,808,113 | 41,808,113 | null | null | null | null |
41,811,691 | comment | wslh | 2024-10-11T18:00:21 | null | Could you expand about grokking [1]? I superficially understand what it means but it seems more important that the article conveys.<p>Particularly:<p>> Grokking can be understood as a phase transition during the training process. While grokking has been thought of as largely a phenomenon of relatively shallow models, grokking has been observed in deep neural networks and non-neural models and is the subject of active research.<p>Does that paper add more insights?<p>[1] <a href="https://en.wikipedia.org/wiki/Grokking_(machine_learning)?wprov=sfti1" rel="nofollow">https://en.wikipedia.org/wiki/Grokking_(machine_learning)?wp...</a> | null | null | 41,811,602 | 41,810,753 | null | [
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] | null | null |
41,811,692 | comment | breck | 2024-10-11T18:00:31 | null | All you have to do is turn your liver on:<p><a href="https://breckyunits.com/liver.html" rel="nofollow">https://breckyunits.com/liver.html</a> | null | null | 41,811,263 | 41,811,263 | null | [
41811981
] | null | null |
41,811,693 | comment | cynicalpeace | 2024-10-11T18:00:31 | null | You're describing me in this comment thread right now. Overwhelmed by the onslaught of political bias.<p>At least Trump's lies have killed less people than Victoria Nuland's | null | null | 41,809,625 | 41,807,681 | null | [
41812012
] | null | null |
41,811,694 | comment | cbsmith | 2024-10-11T18:00:32 | null | Yes, because what obese people lack is education. | null | null | 41,811,623 | 41,811,263 | null | [
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] | null | null |
41,811,695 | comment | sokoloff | 2024-10-11T18:00:35 | null | Bandaids serve a genuinely useful health-promoting purpose. I suspect we'll find the same is true of GLP-1s even if it only addresses part of the entire problem. | null | null | 41,811,663 | 41,811,263 | null | [
41811874
] | null | null |
41,811,696 | comment | throwaway888abc | 2024-10-11T18:00:45 | null | How long till we become voluntary Voyagers [0] ?<p>[0] <a href="https://www.imdb.com/title/tt9664108/" rel="nofollow">https://www.imdb.com/title/tt9664108/</a> | null | null | 41,811,609 | 41,811,263 | null | null | null | null |
41,811,697 | comment | btilly | 2024-10-11T18:01:00 | null | He is better known within physics as the author of <i>This Week's Finds in Mathematical Physics</i>, an archive of which is at <a href="https://math.ucr.edu/home/baez/TWF.html" rel="nofollow">https://math.ucr.edu/home/baez/TWF.html</a>. His more current blog is available at <a href="https://johncarlosbaez.wordpress.com/" rel="nofollow">https://johncarlosbaez.wordpress.com/</a>. | null | null | 41,811,202 | 41,808,127 | null | null | null | null |
41,811,698 | comment | Tuna-Fish | 2024-10-11T18:01:10 | null | Sadly, entirely wrong period.<p>Seriously, though. There are a lot of open questions on dating old and middle kingdom events. The issue is not that there is no good chronology, it's rather that there are multiple reasonable and established chronologies that conflict. Entire careers have been made on basically arguing about dates.<p>We can date important events after the 8th century BCE pretty well for the entire Levant, thanks to the hard work of Babylonian royal astronomers who around that time started systematically recording all celestial events on clay tablets, on which they also recorded the date and occasionally various major events. We can "run the sky backwards" and compare with their records to get a perfect correspondence between their calendar and ours. This is why we know the exact date of the death of Alexander the Great, among other things.<p>An old or middle kingdom observatory with dated slabs that describe enough events to get us a few unambiguously fixed dates is one of those finds that archeologists dream of. | null | null | 41,809,007 | 41,776,631 | null | null | null | null |
41,811,699 | comment | lawgimenez | 2024-10-11T18:01:17 | null | Apple notes has been lagging and crashing a lot. So annoying since it is my most used app. | null | null | 41,810,069 | 41,808,943 | null | null | null | null |
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