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41,811,900 | story | zdw | 2024-10-11T18:21:16 | Making FreeDOS Smaller [video] | null | https://www.youtube.com/watch?v=0zYUHU-ZdqQ | 3 | null | 41,811,900 | 0 | null | null | null |
41,811,901 | comment | CTOSian | 2024-10-11T18:21:19 | null | OOT- sorry :} - @gepiti your username rings a bell... BBS era.. | null | null | 41,773,542 | 41,760,510 | null | null | null | null |
41,811,902 | comment | unsui | 2024-10-11T18:21:22 | null | There is a certain mindset amongst engineers and developers that reachest its zenith in SV: pathological optimization for its own sake.<p>I say pathological because it's a mindset that optimizes for optimization.<p>This mindset is exceedingly effective; it works by looking to discard any obstacles to its own optimization. In a way, it's basically the paperclip problem but done in meatspace.<p>And that is what I see this article highlighting: the costs of Founder Mode (i.e., the slip towards accidental authoritarianism in the pursuit of optimization-at-all-costs).<p>Now, there is much value in having a unified vision for a product or service; Too Many Cooks (TM) can water down the broth.<p>But that doesn't necessarily entail that the antipode (my way or the highway) is the correct answer either.<p>In a world where the value of consensus, of distributed alignment, itself is at stake, it helps to remember that it's not all-or-nothing, but a balancing act. And THAT is worth optimizing for. | null | null | 41,807,845 | 41,807,845 | null | null | null | null |
41,811,903 | comment | ben_w | 2024-10-11T18:21:33 | null | > Someone has an elevated risk of skin cancer due to their genetics? Probably an evolutionary trait that it is more likely for some people to get skin cancer within their lifetime.<p>More than probably, it's called "being white".<p>(And we evolved that for more vitamin D?) | null | null | 41,811,800 | 41,811,263 | null | null | null | null |
41,811,904 | comment | dghlsakjg | 2024-10-11T18:21:34 | null | Do you think overweight people don't know why they're overweight?<p>There are plenty of obese people that understand nutrition just fine, there are obese people who understand it well enough to have lost significant weight and gained it all back.<p>Clearly there is something else going on that we haven't grasped yet. | null | null | 41,811,623 | 41,811,263 | null | [
41811952,
41811960
] | null | null |
41,811,905 | comment | tanananinena | 2024-10-11T18:21:42 | null | This is probably the most interesting (and insightful) paper on grokking I’ve read recently: <a href="https://arxiv.org/abs/2402.15555" rel="nofollow">https://arxiv.org/abs/2402.15555</a> | null | null | 41,811,691 | 41,810,753 | null | null | null | null |
41,811,906 | comment | mrweasel | 2024-10-11T18:21:42 | null | > GLP-1 agonists can actually modulate the reward pathway reducing people's appetite for toxic diets.<p>There are also studies out showing that people just up their sugar intake, so I think the results on how it affects peoples diet is still pending. From what I've seen, people are eating less, but more of it is junk food and sugar.<p>I can absolutely see why people would want to be able to just take a drug and start losing weight, it's hard. My concern is that it takes more than a low body weight to be healthy. You still need exercise, and while that's not an effective weight-lose solution, it is something that most would add when trying to lose weight, and now they're missing out on that part. Arguably exercise is more important than your weight. | null | null | 41,811,653 | 41,811,263 | null | [
41812084
] | null | null |
41,811,907 | comment | tjader | 2024-10-11T18:21:45 | null | I don't think it's just people who have willpower and discipline, it seems to me that for most people it doesn't take as much willpower and discipline to stay at a reasonable weight. These arguments make it sound as if <i>everyone</i> who is at a reasonable weight is there through large amounts of willpower and discipline, but most people I know don't need to exercise X times per week and constantly watch what they eat to keep that weight.<p>It's much easier when you can trust your body feedback and rely on your regular hunger signals, but for most people who benefit from Ozempic for weight loss if they just trust their bodies they will get fat. | null | null | 41,811,667 | 41,811,263 | null | null | null | null |
41,811,908 | comment | red-iron-pine | 2024-10-11T18:21:50 | null | > rather consider the ability of a very small minority of voices to amplify tremendously without sufficient dampening<p>Strongly recommend reading about Wayne Wheeler -- the guy who made Prohibition happen.<p>Prohibition was not especially popular in the US, even before it passed. But Wheeler was able to make a small minority sound very, very loud, and lever politicians accordingly<p><a href="https://en.wikipedia.org/wiki/Wayne_Wheeler" rel="nofollow">https://en.wikipedia.org/wiki/Wayne_Wheeler</a> | null | null | 41,801,691 | 41,801,271 | null | null | null | null |
41,811,909 | comment | btilly | 2024-10-11T18:21:58 | null | I am aware of no case where it clearly made an advance prediction of any behavior that later turned out to be true.<p>I'm aware of quite a few where they managed to "predict" something we already knew.<p>That said, they've made so many "predictions" that I'm sure that some likely worked out by sheer coincidence. | null | null | 41,811,703 | 41,808,127 | null | null | null | null |
41,811,910 | comment | shariharan99 | 2024-10-11T18:22:00 | null | Century Health | Founding Engineer | NYC | Full-Time | Hybrid | 140-160k + Equity<p>We are on a mission is to dramatically accelerate patient access to breakthrough treatments, by leveraging advances in AI and real world clinical data.<p>Today it is far too slow to answer critical questions because the richest clinical data is siloed in academic medical centers, non-profit organizations, and research labs. Our platform does the heavy lifting to gather this real-world clinical data and rapidly generate insights for clinical researchers and life sciences, all while supporting the research community and protecting patient privacy.<p>We are looking for a talented, founding software engineer to join our small, but mighty team. I am prioritizing folks who are in the NYC area, 4+ years of software engineering experience, and have experience working in startups + health-tech.<p>See our more detailed JD: <a href="https://centuryhealth.notion.site/Century-Health-Founding-Engineer-Full-Stack-c719e1cf43454fcd84540b03351dec6e" rel="nofollow">https://centuryhealth.notion.site/Century-Health-Founding-En...</a><p>If you are excited to work on something meaningful and join an early-stage, venture backed team, e-mail me at sanjay (at) century (dot) health! | null | null | 41,709,301 | 41,709,301 | null | null | null | null |
41,811,911 | comment | Mithriil | 2024-10-11T18:22:05 | null | In the conclusion, I like the image:<p>> My mental model [for GPU threads] is that you’ve got a bunch of container ships that can travel at 10% of the speed of light. You’re using them to ship goods around the world. They’re very fast so most of the work is in setting up your harbors so that you can load and unload these container-ships in fractions of a second so that it can sail to do the next thing. It’s not easy to feed these beasts, but if you do it right you can do huge chunks of work in almost no time. | null | null | 41,808,013 | 41,808,013 | null | null | null | null |
41,811,912 | comment | Spivak | 2024-10-11T18:22:12 | null | You have the completely wrong take on this. Dieting destroys your relationship with food. Basically every adult woman exhibits some level of disordered eating because of it— "girl dinner" is both funny because it's true and sad.<p>Being able to lose weight while continuing to eat is a wonderful thing. There is no virtue in spending your willpower making your body do something it desperately doesn't want to do. That's some puritan shit. | null | null | 41,811,662 | 41,811,263 | null | [
41812189,
41811955,
41812000,
41812741
] | null | null |
41,811,913 | comment | chermi | 2024-10-11T18:22:13 | null | Nitpick - this is protein structure prediction, not protein folding | null | null | 41,787,132 | 41,786,101 | null | [
41812048
] | null | null |
41,811,914 | comment | DrillShopper | 2024-10-11T18:22:21 | null | That's not unique to Ozempic and (while I know you didn't make this specific argument, but others in this subthread have) is a piss poor reason to tell someone they shouldn't give it a try. | null | null | 41,811,814 | 41,811,263 | null | [
41811977
] | null | null |
41,811,915 | comment | optimalsolver | 2024-10-11T18:22:25 | null | You know the way that software bloat expands to consume increased computational speed?<p>We're about to see the nutritional equivalent. | null | null | 41,811,662 | 41,811,263 | null | [
41812077,
41812110
] | null | null |
41,811,916 | comment | amatecha | 2024-10-11T18:22:29 | null | From my subjective experience in life, what they very often lacked was parents who set the right examples around food. I know that doesn't apply to everyone of course, but I've witnessed it time and time again - an upbringing with deeply disordered routines/practices around food. It's universal among obese people in my life. I speculate that better awareness of diet/nutrition <i>might</i> help to prevent passing on such behaviours, like not feeding the family exclusively a bucket of KFC or McDonalds, or using food as a reward, etc. etc.. I mean, medication won't actually solve what is caused by behaviour, right? Maybe the behaviour can be reduced on a broader scale, over time, via people making better-informed decisions? If parents know their habits around food are basically ensuring their kids will struggle with obesity, maybe they'll make the effort to do something different? Dunno, it seems like a reasonable consideration. | null | null | 41,811,694 | 41,811,263 | null | null | null | null |
41,811,917 | comment | beretguy | 2024-10-11T18:22:30 | null | a long time ago. | null | null | 41,811,119 | 41,811,119 | null | null | null | null |
41,811,918 | comment | mock-possum | 2024-10-11T18:22:30 | null | And make no mistake we <i>will</i> find something new to moralize and shame about because <i>that’s what we do</i> | null | null | 41,811,611 | 41,811,263 | null | null | null | null |
41,811,919 | comment | rfrey | 2024-10-11T18:22:40 | null | I eat almost zero processed foods and very little sugar - mostly from fruit. I shop exclusively on the perimeter of the grocery store and eat at a restaurant maybe once a month, with all my meals cooked at home. I try my best to limit portions.<p>I have been overweight my entire life. I have successfully lost weight with up to eight months of calorie restriction, so my willpower is just fine, thank you. I have always gained it back, and you calling me out for some kind of moral turpitude is not helpful.<p>Your "eat like an adult" finger waggling is condescending, and claiming anyone who thinks obesity is more complex than "just eat better food, bro" is anti-intellectual and anti-science is just insulting - and not particularly "pro science" either. | null | null | 41,811,762 | 41,811,263 | null | [
41811957
] | null | null |
41,811,920 | comment | logicchains | 2024-10-11T18:22:43 | null | <a href="https://www.theguardian.com/us-news/2024/oct/04/fluoridation-water-epa-risk-assessement" rel="nofollow">https://www.theguardian.com/us-news/2024/oct/04/fluoridation...</a> | null | null | 41,811,875 | 41,811,263 | null | [
41812803,
41812073,
41812097
] | null | null |
41,811,921 | story | shcheklein | 2024-10-11T18:22:44 | Scalable PDF Document Processing | null | https://medium.com/dvc-data-version-control/scalable-pdf-documents-processing-with-datachain-and-unstructured-io-a2952b59dadf | 3 | null | 41,811,921 | 0 | null | null | null |
41,811,922 | comment | dfxm12 | 2024-10-11T18:22:47 | null | I don't think this registers as apathy in this context. Maybe you live in a country that has nuclear weapons and can vote for one leader or another. This may or may not have some impact on things. Certainly, we cannot influence what other countries do with their arsenals. Our mental stacks can only run so deep & I'd wager for most of us, the things that <i>are</i> in our sphere of influence simply take priority. | null | null | 41,811,326 | 41,807,681 | null | null | null | null |
41,811,923 | comment | andrewmcwatters | 2024-10-11T18:22:49 | null | site:ncbi.nlm.nih.gov ghrelin, reward<p>It goes on and on and on. In lab mice, it has been shown you can alter production in as little as 10 days. Human hormone production has similar turn around times. | null | null | 41,811,871 | 41,811,263 | null | null | null | null |
41,811,924 | comment | wholinator2 | 2024-10-11T18:22:53 | null | I'm curious about the paradoxes, if you have any on hand | null | null | 41,811,750 | 41,811,263 | null | [
41812790,
41811971
] | null | null |
41,811,925 | comment | miles | 2024-10-11T18:23:11 | null | Thank you for crafting and sharing this. Have been looking for a modern MacDown[0] replacement, and this fit the bill nicely. Especially appreciate the reasonable, one-time cost and support for local storage.<p>The "Key Features" section mentions "Export notes to PDF"; please consider adding an "Export notes to HTML" option. Custom theme support for the preview pane via CSS would be helpful too.<p>[0] <a href="https://macdown.uranusjr.com" rel="nofollow">https://macdown.uranusjr.com</a> | null | null | 41,808,943 | 41,808,943 | null | null | null | null |
41,811,926 | comment | arcticbull | 2024-10-11T18:23:14 | null | > "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape.<p>Studies show it just doesn't work.<p>There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667.<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407685/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10407685/</a><p>[edit] not to mention for those 1 in 11, the average weight regain over 5 years is 80%.<p><a href="https://www.sciencedirect.com/science/article/pii/S0002916523063748" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S000291652...</a> | null | null | 41,811,603 | 41,811,263 | null | [
41812006,
41812313,
41812180,
41811980,
41812663,
41812098,
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41812027,
41812471,
41811979,
41812083
] | null | null |
41,811,927 | comment | cyberax | 2024-10-11T18:23:17 | null | Not really. Mice are naturally genetically pre-disposed to cancer.<p>So in general, if something _doesn't_ cause cancer in mice, then it's probably safe for humans. The reverse is not necessarily true.<p>Also, GLP-1 was associated with thyroid, not pancreatic cancer. | null | null | 41,811,840 | 41,811,263 | null | [
41812308
] | null | null |
41,811,928 | comment | hinkley | 2024-10-11T18:23:20 | null | The first rule of breaking the law is never break 2 laws at the same time.<p>If you’re going to “litter” plants onto someone else’s property, your reasoning for what plants to plant needs to be immaculate.<p>That doesn’t have to be a big complicated thing. Plant local wildflowers, from low weed content seed sources. Plant common imported plants like you find at the local nursery. Don’t pick random shit that’s invasive, or has poor nutrition that starves local insects. Don’t jump fences, think really hard about if you want to be taking things away like trash rather than relocating it on the property. | null | null | 41,789,228 | 41,789,228 | null | null | null | null |
41,811,929 | comment | WhatIsDukkha | 2024-10-11T18:23:24 | null | <a href="https://en.wikipedia.org/wiki/Naltrexone#Controversies" rel="nofollow">https://en.wikipedia.org/wiki/Naltrexone#Controversies</a> | null | null | 41,811,755 | 41,811,263 | null | null | null | null |
41,811,930 | comment | arcticbull | 2024-10-11T18:23:36 | null | There's no evidence that GLP-1s cause cancer in any meaningful amount, but obesity definitely does. Either way the only cancer they found any correlation to was thyroid which is one of the most treatable -- over 99% survival rates. | null | null | 41,811,862 | 41,811,263 | null | [
41812051
] | null | null |
41,811,931 | comment | preinheimer | 2024-10-11T18:23:51 | null | I run a product that has a free tier. There's one person with ~30 accounts, each with their own unique email address (gmail).<p>Credit cards are a decent tool to stem the tide of people making lots of free accounts. | null | null | 41,811,812 | 41,807,783 | null | [
41813015
] | null | null |
41,811,932 | comment | pyrophane | 2024-10-11T18:24:40 | null | One thing that it seems we are just starting to talk about with these drugs is the associated muscle and bone density loss. I'm concerned that this generation of GLP-1 early adopters will wind up more frail and suffer a lower quality of life in old age as a result. | null | null | 41,811,263 | 41,811,263 | null | [
41813259,
41812228,
41812138
] | null | null |
41,811,933 | comment | honkycat | 2024-10-11T18:24:49 | null | Why doesn't everyone play piano? Why isn't every person a super athlete? Why doesn't everyone meditate 40 minutes a day? Why doesn't everyone study super hard in school and become an engineer or doctor or lawyer?<p>The hard truth: Not everyone is capable of those things. Period.<p>40% of the US population is considered obese. That is a HUGE number. At a certain point, you can no longer blame individuals. There is something wrong, and we identify it as an environmental problem.<p>So if we have a drug that will make a huge amount of people healthy, what is the downside? And for the record: Ozempic affects appetite so they eat better, that is part of the drug. | null | null | 41,811,617 | 41,811,263 | null | [
41812205
] | null | null |
41,811,934 | comment | 0xdde | 2024-10-11T18:25:01 | null | No, but I expect a better argument than a link to that page. | null | null | 41,811,873 | 41,801,271 | null | [
41812223
] | null | null |
41,811,935 | comment | p_j_w | 2024-10-11T18:25:07 | null | Humans use our brains to drive. Unless you're planning on popping an actual human brain or something that can perform equivalently into the car, you'd do well to consider more superior sensor suites. | null | null | 41,807,015 | 41,805,706 | null | null | null | null |
41,811,936 | comment | cubefox | 2024-10-11T18:25:07 | null | And apparently the pure manufacturing cost for Ozempic is relatively low:<p>> the active drug in Ozempic can be produced for about 29 cents for a month’s supply, or 7.2 cents for a typical weekly dose, the research found. It’s not cheap to make — semaglutide costs over $70,000 per kilogram. But only a tiny quantity of the drug is used in each weekly dose.<p>> <a href="https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nordisk-facing-pressure-as-study-finds-1000-appetite-suppressant-can-be-made-for-just-5/" rel="nofollow">https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nor...</a><p>I think this makes it likely that strongly ramping up the supply is not a major problem. | null | null | 41,811,587 | 41,811,263 | null | [
41813102
] | null | null |
41,811,937 | comment | ufmace | 2024-10-11T18:25:09 | null | I'm not sure what value adding a DeadManService would have then. Probably simpler to just have the attorney's instructions say, "Hire a technical consultant to carry out the following:". | null | null | 41,811,475 | 41,809,879 | null | null | null | null |
41,811,938 | comment | throwaway48476 | 2024-10-11T18:25:14 | null | So, are you going to leave chrome then? | null | null | 41,809,962 | 41,809,698 | null | null | null | null |
41,811,939 | comment | 082349872349872 | 2024-10-11T18:25:17 | null | at Tandem, even the company coffee mugs had redundancy: <a href="https://i.etsystatic.com/33311136/r/il/08fbca/5271808290/il_680x540.5271808290_3yq9.jpg" rel="nofollow">https://i.etsystatic.com/33311136/r/il/08fbca/5271808290/il_...</a> | null | null | 41,811,298 | 41,811,298 | null | null | null | null |
41,811,940 | comment | abeppu | 2024-10-11T18:25:24 | null | Does anyone have references on any explanation, or even partial explanation, on why this might be the case?<p>The published stuff I can find seems to be at the level of anecdata, scarcely better than "I know a guy who..."<p>- What people talk about on social media: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/</a><p>- Some people made large "reckless" life choices: <a href="https://academic.oup.com/qjmed/advance-article-abstract/doi/10.1093/qjmed/hcae095/7665706" rel="nofollow">https://academic.oup.com/qjmed/advance-article-abstract/doi/...</a> | null | null | 41,811,834 | 41,811,263 | null | [
41812186,
41812064,
41812037
] | null | null |
41,811,941 | comment | throwaway63467 | 2024-10-11T18:25:35 | null | I’m just back from the US and watching some TV there in the hotel it seems very much like they’re pushing it into the mainstream, they literally have a commercial where “fat” people congregate in the street to march together picking up Ozempic… So I totally assume it will be widespread in a few years unless they discover some serious side effects. | null | null | 41,811,607 | 41,811,263 | null | [
41812446
] | null | null |
41,811,942 | comment | cynicalpeace | 2024-10-11T18:25:36 | null | Correct. Russians should absolutely go home.<p>You're pushing forward a neoliberal wet dream that he wants the whole eastern bloc. | null | null | 41,809,598 | 41,807,681 | null | null | null | null |
41,811,943 | comment | heraldgeezer | 2024-10-11T18:25:44 | null | [flagged] | null | null | 41,811,263 | 41,811,263 | null | null | null | true |
41,811,944 | comment | FireBeyond | 2024-10-11T18:25:52 | null | > your car is doing nothing for most of it’s lifetime. renting it out via turo or as a taxi makes sense.<p>A lifetime that will be massively shortened by it running as a taxi 20 hours a day. | null | null | 41,809,069 | 41,805,706 | null | null | null | null |
41,811,945 | comment | null | 2024-10-11T18:26:10 | null | null | null | null | 41,811,540 | 41,809,698 | null | null | true | null |
41,811,946 | comment | red-iron-pine | 2024-10-11T18:26:13 | null | they tried to. 2 impeachments + felony convictions | null | null | 41,801,896 | 41,801,271 | null | null | null | null |
41,811,947 | comment | tapirl | 2024-10-11T18:26:18 | null | > Go is supposed to be an improvement over C for most programming tasks.<p>This is not true. s/Go/Zig is true. That is why I'm switching to Zig now. | null | null | 41,807,846 | 41,769,275 | null | null | null | null |
41,811,948 | comment | degrees57 | 2024-10-11T18:26:20 | null | I'm not a fan of email + magic link. I know of two security gateways which "click" on the link to check to see if it ends up going to a known malicious website. So then the end user calls in a trouble ticket, because the login authorization page says their magic link is already expired (before they even got it).<p>So for me, email + email OTP is the way to go. | null | null | 41,802,778 | 41,801,883 | null | null | null | null |
41,811,949 | comment | Agingcoder | 2024-10-11T18:26:21 | null | This looks very interesting. Would you have references ? ( not necessarily on grokking but about the part where computation can occur only when the right balance is found ) | null | null | 41,811,816 | 41,810,753 | null | [
41812765
] | null | null |
41,811,950 | comment | akira2501 | 2024-10-11T18:26:23 | null | Were they humanized mice or not? | null | null | 41,811,801 | 41,811,263 | null | null | null | null |
41,811,951 | comment | marxisttemp | 2024-10-11T18:26:33 | null | okay. I grew up on a farm in Maine btw, I can guarantee I have more interaction with Trump voters than you. My own brother has swallowed the anti trans propaganda. I’ve heard all the tired, hateful arguments they make but have fun wasting your time listening to both sides | null | null | 41,811,362 | 41,804,460 | null | null | null | null |
41,811,952 | comment | amatecha | 2024-10-11T18:26:34 | null | Education may involve "finding a strategy that works for you". There are so, so many different ways to combat disordered eating. These are learnable things. My thought around "better education" is that the cycle of disordered eating can be stopped at some point before parents pass it on to their kids, at least (as I just posted in adjacent comment <a href="https://news.ycombinator.com/item?id=41811916">https://news.ycombinator.com/item?id=41811916</a> ). I absolutely recognize how insanely difficult it is to come back from disordered eating and stay at a lower weight after finally reaching it.<p>Though, now that you ask, I do think that many people don't actually know why they are overweight. They say it's because "McDonald's is cheaper than buying good food", not realizing the McDonalds won't satiate them and they will eat/spend more because their body is starved for proper nutrition. Watch the series "Supersize vs. Superskinny" and observe how nearly every participant is utterly clueless as to the underlying causes of their challenges on either size of the disordered-eating scale. | null | null | 41,811,904 | 41,811,263 | null | null | null | null |
41,811,953 | comment | Jeramyrenner | 2024-10-11T18:26:43 | null | [dead] | null | null | 41,773,212 | 41,773,212 | null | null | null | true |
41,811,954 | comment | amar-laksh | 2024-10-11T18:26:45 | null | Oh thanks! I was looking for something similar when I posted. | null | null | 41,809,965 | 41,806,629 | null | null | null | null |
41,811,955 | comment | Fauntleroy | 2024-10-11T18:27:03 | null | It doesn't make you magically lose weight, it just gets you closer to "girl dinnering" with less cognitive load. The weight loss comes from eating less. | null | null | 41,811,912 | 41,811,263 | null | [
41812125
] | null | null |
41,811,956 | comment | Blackthorn | 2024-10-11T18:27:17 | null | Going by the results around addiction, I'm betting on #2 with reduced alcohol consumption. | null | null | 41,811,539 | 41,811,263 | null | null | null | null |
41,811,957 | comment | andrewmcwatters | 2024-10-11T18:27:17 | null | In 8 months of losing 2 pounds a week, you would have lost roughly 64 pounds. You could have been losing more than that which is common on diets where added sugar is removed. But you're talking to someone who has worked with people with class 3 obesity and has seen the weight successfully stay off.<p>You're omitting details. You simply didn't change your eating habits. Statistically, this detail you shared is also overwhelmingly the documented reason why people fail to keep off weight. Almost entirely, people who reside in higher classes of obesity have no idea what their relative consumption habits are in comparison to those with lower BMIs.<p>This may come as a surprise to you, but most other countries where obesity is not a problem, most sugar consumption is also from fruit and these peoples' diets _don't_ contain anywhere near the amount of added sugar an American diet does. This isn't a special thing to point out, you just think it is because you have no other frame of reference. | null | null | 41,811,919 | 41,811,263 | null | [
41812065,
41812111,
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] | null | null |
41,811,958 | comment | marxisttemp | 2024-10-11T18:27:27 | null | > The left is very clearly attempting to curtail the right to free speech<p>How?<p>> free association,<p>How?<p>> and economic freedom.<p>How? | null | null | 41,811,179 | 41,804,460 | null | null | null | null |
41,811,959 | comment | Gooblebrai | 2024-10-11T18:27:33 | null | Sounds like this criticism would be valid for fundamental physics but there are many other physics fields with experimental results that become technology. | null | null | 41,811,534 | 41,808,127 | null | [
41812208,
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] | null | null |
41,811,960 | comment | 2snakes | 2024-10-11T18:27:35 | null | Psychology of hunger behaviors. | null | null | 41,811,904 | 41,811,263 | null | null | null | null |
41,811,961 | comment | johnklos | 2024-10-11T18:27:39 | null | Embracing ignorance is a trait of masculinity? Ok. That's a plausible evaluation.<p>The author links to a piece about how "it's harder to be a man than a woman", which basically asserts (I'm generalizing liberally) that people are too weak to question social norms and are simply unwitting victims of what society teaches them. Perhaps what's discussed there can be applied to college enrollment.<p>If the issue, which the author appears to suggest, is that men can't help but try to be and want to be what they're taught and told they should be, then that leads to wondering what can be done about it. But so long as these masculine insecure men lean right, perhaps at least in part due to their inability to see beyond us-versus-them, and so long as it's socially acceptable to be right leaning, with all the implied racism, sexism, xenophobia and so on that go with it, things won't change much.<p>Growing up, I was staunchly anti-religion. Religions have done more to harm humankind than any other thing, yet we're taught to "respect" religion and religious beliefs, even when those religions support misogyny, war, slavery, pedophilia, et cetera. I saw through that and marveled at how hard it was for most other people to see through it. But now, in 2024, we (most of us) at least try to squelch our desire to punish the victims when they speak out, which is a start.<p>Perhaps it's time to do the same for toxic masculinity and right-leaning tendencies. Perhaps it should be socially acceptable to call men out when they're being assholes, to lean in to what they derisively refer to as cancel culture. Perhaps right-leaning beliefs should wholesale be called out for encouragement of unacceptance, particularly and especially when using religions as justification, while at the same time wanting those same religious beliefs to be "respected" because they include some good. Frankly, I'm tired as hell at the same people who want to punish immigrants and poor people saying that they believe in following Jesus, as though Jesus would say, "sure, send those needy fuckers packing".<p>It's not like men are nice and accepting when people toe the line. Let's lean in to being the assholes that "masculine" men already tell us we are. | null | null | 41,811,050 | 41,811,050 | null | null | null | null |
41,811,962 | story | kumarm | 2024-10-11T18:27:45 | Amazon India contests – One man wins all contests though 1000's answer correctly | null | https://twitter.com/Crypt0holicpoet/status/1843564129900212405 | 3 | null | 41,811,962 | 1 | [
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] | null | null |
41,811,963 | comment | akira2501 | 2024-10-11T18:27:51 | null | Eating animals and animal welfare are two entirely different things. We could all be vegetarians and still be intentionally or unintentionally intolerably cruel to all other life on this planet. | null | null | 41,811,609 | 41,811,263 | null | null | null | null |
41,811,964 | comment | k__ | 2024-10-11T18:27:54 | null | How are the side effects?<p>I read plastic surgeons said it was bad for your skin and people would look much older when they take it for a few months.<p>Yet, I also read it was generally good for your health, not just in terms of weight loss. | null | null | 41,811,263 | 41,811,263 | null | [
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] | null | null |
41,811,965 | comment | more_corn | 2024-10-11T18:27:57 | null | Only 6%? | null | null | 41,808,357 | 41,808,357 | null | null | null | null |
41,811,966 | comment | risho | 2024-10-11T18:28:02 | null | it works on asahi without issue. that is with x86 to arm translation, directx to vulkan translation, windows to linux translation and 4k page to 16k page translation running in a virtual machine.<p>as for how well fromsoft games run on windows you might have been right 12 years ago when dark souls 1 came out initially. it was a mess at the time, but souls games have been running just fine on windows(and linux for that matter) for years. it's only on macos that it is a mess. this has nothing to do with fromsoft and everything to do with macos. | null | null | 41,810,641 | 41,799,068 | null | null | null | null |
41,811,967 | comment | ecnahc515 | 2024-10-11T18:28:06 | null | Just a note that `x/sync` is not part of the Go std lib. | null | null | 41,810,739 | 41,809,262 | null | null | null | null |
41,811,968 | comment | jprete | 2024-10-11T18:28:06 | null | Ozempic does not simply limit your appetite, it seems to also affect how much reward your brain feels from different foods (and activities!), which would make it easier to override those anticipated rewards with conscious choices. | null | null | 41,811,620 | 41,811,263 | null | null | null | null |
41,811,969 | comment | hinkley | 2024-10-11T18:28:07 | null | Ron Finley, who is mentioned in the article, sells shirts that say, “Plant some shit.” But I don’t like the art direction on the current design and am forever kicking myself for not buying one of the originals. | null | null | 41,789,228 | 41,789,228 | null | null | null | null |
41,811,970 | comment | cuddlybacon | 2024-10-11T18:28:14 | null | I use Teams on the daily, and think it is a legit question.<p>On the one hand, the app crashes at least once a day. On the other, haven't seen this issue of distracting notifications or important discussions being drowned out by chatter. Those are constantly brought up with Slack. | null | null | 41,810,395 | 41,805,009 | null | null | null | null |
41,811,971 | comment | ben_w | 2024-10-11T18:28:18 | null | <a href="https://en.wikipedia.org/wiki/Mere_addition_paradox" rel="nofollow">https://en.wikipedia.org/wiki/Mere_addition_paradox</a><p>and<p><a href="https://en.wikipedia.org/wiki/Utility_monster" rel="nofollow">https://en.wikipedia.org/wiki/Utility_monster</a> | null | null | 41,811,924 | 41,811,263 | null | null | null | null |
41,811,972 | comment | paulryanrogers | 2024-10-11T18:28:26 | null | > Microsoft would hard-fork Chromium and Brave et al would just switch their upstream to Edge.<p>Doubt.<p>I'll believe it when I see it. Maintaining a hard fork is almost as hard as a greenfield browser like old Edge or old Opera. There are no serious competitors doing hard Chromium forks besides Apple. (Afraid to admit Firefox isn't a serious competitor anymore.) | null | null | 41,810,534 | 41,784,287 | null | null | null | null |
41,811,973 | comment | nullc | 2024-10-11T18:28:27 | null | Glad you're having a good time, but the broad ranging psychological effects are concerning. | null | null | 41,811,603 | 41,811,263 | null | [
41812054,
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] | null | null |
41,811,974 | comment | honkycat | 2024-10-11T18:28:37 | null | Good for you man. 40% of the US is obese, we need a solution for better health outcomes. | null | null | 41,811,899 | 41,811,263 | null | [
41813233,
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] | null | null |
41,811,975 | comment | randomdata | 2024-10-11T18:28:49 | null | <i>> In short, some would argue suffering is multiplied by the number of sentient beings that experience it</i><p>Factored by how cute the animal is. As a producer of plants for human consumption, it's quite obvious that orders of magnitude more animals are harmed in that process than are ever harmed in traditional meat production. But they're mostly ugly insects, so nobody cares. | null | null | 41,811,750 | 41,811,263 | null | null | null | null |
41,811,976 | comment | taylodl | 2024-10-11T18:28:53 | null | Male violence is not toxic masculinity.<p>Before posting my response, I did a little bit of research to check my assumption: is toxic masculinity on the rise? The overall answer, keeping in mind this is a complex issue and there's people advocating for calling it something else, is yes, it's been on the rise. Several factors are cited for its rise.<p>None of that changes the fact this author has confused "toxic masculinity" with "masculinity", and the fact that he has unironically done so is an indicator to me how much toxic masculinity has increased: people are now just calling it "masculinity." | null | null | 41,811,769 | 41,811,050 | null | [
41813061
] | null | null |
41,811,977 | comment | lurking_swe | 2024-10-11T18:28:55 | null | i don’t disagree. Just pointing out that (obviously) this should be a last resort drug. AFTER someone has tried lifestyle interventions for a few years IMO.<p>The problem is when someone does NOT put in the effort to talk to their doctor, meet with a dietician, learn about healthy eating, and put in an honest effort to improve their life before just popping a pill.<p>That said, i think it’s great that’s it’s helping people who otherwise would just be obese and have many other health issues due to that. It’s a big risk factor. | null | null | 41,811,914 | 41,811,263 | null | null | null | null |
41,811,978 | comment | dragonwriter | 2024-10-11T18:29:06 | null | No, if its only a “loss” due to counting amortization of the sunk cost of initial acquisition, throwing them in the trash will lose you <i>more</i> money. The only way you can avoid the key cost is to travel back in time and not buy them, and, yeah, if you can do that instead, maybe you should (but, the time travel technology will make you more money than the H100s would ever cost, so maybe don't bother.) | null | null | 41,808,281 | 41,805,446 | null | null | null | null |
41,811,979 | comment | oldpersonintx | 2024-10-11T18:29:18 | null | [dead] | null | null | 41,811,926 | 41,811,263 | null | null | null | true |
41,811,980 | comment | pfdietz | 2024-10-11T18:29:29 | null | I've lost 27 pounds since May (12%). Eliminating most carbs and doing lots of walking. I think being on metformin helped. | null | null | 41,811,926 | 41,811,263 | null | [
41812175,
41812043
] | null | null |
41,811,981 | comment | mock-possum | 2024-10-11T18:29:31 | null | > “Is it bad for my liver to be off most of the time?” It's generally not healthy to keep your major organs in the off state. If you never open your eyes, you go blind.<p>I feel like this is missing the obvious follow up question, “is it bad for my liver to be <i>on</i> most of the time?” | null | null | 41,811,692 | 41,811,263 | null | [
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] | null | null |
41,811,982 | comment | e_y_ | 2024-10-11T18:29:33 | null | Citation? Humans are not constantly moving their heads to the degree that chickens do, and I find it doubtful that the micro movements from our head (which our eyes have to adjust for with the vestibulo-ocular reflex so things aren't blurry, similar to image stabilization in cameras) are large enough to infer depth. | null | null | 41,807,491 | 41,805,706 | null | null | null | null |
41,811,983 | story | levlaz | 2024-10-11T18:29:40 | Started a guide to writing FUSE filesystems in Python | null | https://gwolf.org/2024/10/started-a-guide-to-writing-fuse-filesystems-in-python.html | 49 | null | 41,811,983 | 14 | [
41812623,
41812796,
41813001,
41812556
] | null | null |
41,811,984 | comment | kumarm | 2024-10-11T18:29:46 | null | It is clear that either the Amazon India social admins or a third party they hired to run the contests are giving away prizes to their friends or insiders.<p>ChiragG14 has won at least 5 of their contests which most people correctly answer. | null | null | 41,811,962 | 41,811,962 | null | null | null | null |
41,811,985 | comment | renegade-otter | 2024-10-11T18:29:53 | null | I take cabs in NYC often and that never happens. | null | null | 41,805,674 | 41,805,515 | null | null | null | null |
41,811,986 | comment | mikedelfino | 2024-10-11T18:29:54 | null | I couldn't reproduce the tty example, but it might as well be a mistake on my side. Other than this, the sandboxing spec itself is as safe as I'd expect. I reckon that Wayland applications not packaged to require $HOME access or some dbus services are not known to escape the sandbox. This seems to be the case of Firefox, afaict. | null | null | 41,810,131 | 41,796,030 | null | null | null | null |
41,811,987 | comment | cyberax | 2024-10-11T18:29:56 | null | One other note: the current peptide-based GLP-1 drugs are not likely to be the permanent solution. Injectables are just too problematic for that.<p>Several companies are now working on more classic small-molecule drugs targeting the same receptors. So it's likely that in several years we'll get a pill with the same effects.<p>Yes, there's technically a pill version of Ozempic already (Rybelsus), but it works by making the stomach wall to be slightly permeable to peptides. You can guess that it has pretty unpleasant side effects, and an awesome bioavailability of 0.7% | null | null | 41,811,263 | 41,811,263 | null | [
41812329
] | null | null |
41,811,988 | comment | noch | 2024-10-11T18:29:59 | null | > Saturday is injection day, but Sunday is where it really becomes quite noticeable that I took it. Monday-Wednesday is cruising altitude and the effects are good but not over the top. Thursday I can feel it tapering, and today ... well, I'm looking forward to tomorrow's injection. I might switch to a twice-a-week split dose at some point to ease the peaks and valleys.<p>Perhaps coincidentally, this is similar to my experience with week long fasts: After 48 hours I feel like a precision missile cruising towards my target until about 5-6 days later.<p>But I will use a suitable GLP-1 based drug, because, man, fasting feels unbearably brutal for me after 6 days: profuse sweat, increased heart rate, brief but intense panic attacks, an insane level of sad (but not depressed) introspection, a hairpin trigger temper. I become a ridiculous mess. There's got to be a better way!<p>Thanks for sharing your experience and insight! | null | null | 41,811,603 | 41,811,263 | null | null | null | null |
41,811,989 | comment | retrocryptid | 2024-10-11T18:30:17 | null | i'm confused. what does Hidankyo have to do with large language models? | null | null | 41,807,681 | 41,807,681 | null | null | null | null |
41,811,990 | comment | crooked-v | 2024-10-11T18:30:22 | null | The same thing that always happened to it: for a lot of people it just doesn't work. | null | null | 41,811,850 | 41,811,263 | null | null | null | null |
41,811,991 | comment | brudgers | 2024-10-11T18:30:25 | null | <i>but never have this acquaintance seemingly think of me if I’m not directly asking them to hang.</i><p>Treating relationsips non-transactionally, helped me. Sure, sometimes I might feel a bit disappointed. That's a hazard of para-social thinking. Relationships have asymmetries. Hence the friendship paradox: <a href="https://en.wikipedia.org/wiki/Friendship_paradox" rel="nofollow">https://en.wikipedia.org/wiki/Friendship_paradox</a><p><i>Maybe I’m a boring person?</i><p>Well half of all people are more boring than average...But mostly adult lives are complex. You probably don't rate as highly as someone's child, partner, or established social circle. These are long term relationships. Good luck. | null | null | 41,810,889 | 41,810,889 | null | null | null | null |
41,811,992 | comment | djsavvy | 2024-10-11T18:30:25 | null | My pet crackpot theory is that within the next 100 years semaglutide is going to be in the drinking water (much like fluoride) because the benefit to society is going to be too hard to pass up on. However, it seems that it's delivered via injection so maybe putting it in the water supply wouldn't even be effective. | null | null | 41,811,263 | 41,811,263 | null | [
41812075,
41812176
] | null | null |
41,811,993 | comment | mrweasel | 2024-10-11T18:30:42 | null | > Ozempic isn't a fix, it's a bandaid.<p>My original impression was that it was suppose to be a crutch, helping you get started on a healthy lifestyle. So if you are to heavy to exercise without hurting yourself it could help you lose that initial weight. Or it can help you with your appetit, while you adjust your diet.<p>You also can't stay on Ozempic, you have to continuously increase you dose to get the same effect, so it's simply not viable to keep taking it for an extend period of time. That's at least the impression I've been getting from talking to people working at pharmacies. | null | null | 41,811,663 | 41,811,263 | null | null | null | null |
41,811,994 | comment | monkey_slap | 2024-10-11T18:30:44 | null | > is there a space inside Campfire for more disposable type conversations?<p>Yes absolutely. We have messages (DMs and group) as well as calls. We have a ton of "throwaway" conversations in messages. | null | null | 41,811,538 | 41,805,009 | null | null | null | null |
41,811,995 | comment | myaccountonhn | 2024-10-11T18:30:45 | null | It seems to be the case. See the other thread of people not knowing what a file system is.<p>In the past tech education felt useless because teachers were so far behind, maybe it’s time to revisit now because now the younger generation is far behind. | null | null | 41,806,842 | 41,801,334 | null | null | null | null |
41,811,996 | comment | crooked-v | 2024-10-11T18:30:52 | null | Do you drink coffee or tea? | null | null | 41,811,899 | 41,811,263 | null | [
41813257
] | null | null |
41,811,997 | comment | Blackthorn | 2024-10-11T18:30:55 | null | Nobody ever gets sus about needing to take heart medication every day to stay alive but the moment it becomes about how I take Lexapro every day they get real preachy. | null | null | 41,811,734 | 41,811,263 | null | [
41812058
] | null | null |
41,811,998 | comment | jsbg | 2024-10-11T18:30:58 | null | maybe your parents aren't old enough to remember how much of the population could expect to die in wars before nuclear weapons (i.e. mutually assured destruction) existed | null | null | 41,807,938 | 41,807,681 | null | null | null | null |
41,811,999 | comment | DCH3416 | 2024-10-11T18:30:58 | null | Screw that | null | null | 41,811,850 | 41,811,263 | null | null | null | null |
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