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Tests conducted on milk over the past few days showed 24 - all from the mentioned firms - of 1,202 batches were contaminated, the agency said on Thursday. |
Products of China's Mengniu Dairy Co. Ltd. are on the shelves of a supermarket in Hong Kong Friday, Sept. 19, 2008. [Agencies] |
The AQSIQ has asked the three companies to recall all their contaminated products. |
Eleven of the 121 Mengniu batches that were tested contained melamine, a chemical that makes milk appear rich in protein during quality tests, but can also cause kidney problems. |
Melamine is used frequently to make products including plates, bowls and mugs, but is strictly banned in the food industry. |
The highest concentration of melamine was found in samples from Bright Diary - six of its 81 batches were contaminated. |
Every kilogram of its liquid milk contained 8.6 mg of the chemical. |
Seven of the 81 Yili batches tested contained melamine. |
The three firms' milk powder products also tested positive for melamine, and they have begun recalling them. |
"Yili group had already recalled all of its contaminated milk powder products in the shortest period of time," Yili said in a proclamation. |
The other two promised a similar action in their so-called "Earnest Proclamations". |
On Friday, the National Development and Reform Commission required price administration bodies nationwide to closely watch local markets to prevent price hikes on milk powder products. |
The notice came out two days after the Shanghai Evening Post reported the prices of imported milk powder products might rise. |
But four major foreign milk exporters to the Chinese market all promised they would not raise their prices. |
"It is not proper to raise the price during this special period of time," US milk powder manufacturer Wyeth was quoted as saying by Jiangsu-based Yangtze Evening Post. |
A total of 6,244 infants nationwide who were fed contaminated milk products produced by Sanlu Group have been diagnosed with various urinary tract problems, including kidney stones, according to the latest update published on Thursday. Four babies have died.<eot>The Tamvakopoulos lab focuses on all aspects of Pharmacology and Pharmacotechnology to explore and develop novel therapeutic approaches with a particular focus on cancer. As a lab, we are interested in investigating the mechanisms of pharmacological action, and examine the effects and interactions of drugs on living organisms at the cellular, molecular and biochemical level. Accordingly, research efforts are directed toward developing targeted therapies based on cytotoxic and/or antiangiogenic small molecules, in conjunction with discovering bioactive compounds that could be potentially developed to drugs. In addition, the lab maintains a pertinent interest in discovering novel biomarkers of disease, in order to monitor efficacy of therapy as well as to design targeted molecules. |
Our efforts of anticancer drug discovery/development include identification of parameters that will lead to the maximal beneficial effectiveness including, drug-carrier for administration, dosing, scheduling, and route of administration. The development and application of novel mass spectrometric techniques allow us to place emphasis on pharmacokinetic and drug metabolism questions, yielding better understanding of pharmacologic action with beneficial consequences to the design of future therapies. The Tamvakopoulos lab, currently exploits sophisticated mass spectrometry techniques to study the pharmacokinetic properties of bioactive leads in mice, tissue distribution (e.g., tumors) and their in vitro and in vivo drug metabolism. Modern analytical instrumentation such as liquid chromatography (LC) coupled with a hybrid triple quadruple and linear ion trap system is available to facilitate those studies. Through collaborations within BRFAA it is possible to access other platforms with distinct niches and capabilities (e.g., quadruple time-of-flight QqTOF MS-MS system, Thermo Scientific™ Orbitrap Elite™ Hybrid Ion Trap-Orbitrap Mass Spectrometer) for more in-depth characterization of metabolites or metabolomics and proteomic studies. |
Importantly, the Tamvakopoulos Lab operates for a number of years under the ISO:17025 accreditation. It has also spearheaded a collaborative effort between the GLP certified pharmacology facility and an adjacent 30 bed clinical unit (part of Sotiria Hospital) for the execution of clinical trials (Phase I Unit), under the umbrella of BRFAA. This collaboration involves volunteer recruitment, drug design, sample collection, drug level measurements and statistical evaluation. Two CROs participate in the effort. Following drug dosing, pharmacokinetic and pharmacodynamic/biomarker (PK-PD) measurements will be performed in the BRFAA GLP laboratory. This represents a unique opportunity in Greece that will allow the Biomedical Research Foundation of the Academy of Athens to participate in the process of developing generic drugs but of equal significance is our ongoing involvment in the evaluation of novel therapeutics. A formal meeting of the Clinical Trials initiative was held in BRFAA in October 2014 in which we presented our specific role and vision for this important objective |
Dr Tamvakopoulos, Professor Niopas from the School of Pharmacy, Aristotle University of Thessaloniki, Mina Gaga, MD, Athens Chest Hospital Sotiria during the meeting |
Dr Tamvakopoulos during the presentation for the specific role and vision of Pharmacology-Pharmacotechnology Division in the Clinical Trial Initiative. |
--- Quick Links -------------------- BRFAA Home PagePosition OpportunitiesProcurement Research Drug Discovery - Drug Development Publications Lab Members OPENSCREEN-GR ISO 17025<eot>John Grohol on psychiatric drug withdrawal at Psych Central. Join the conversation – Everything Matters |
John Grohol at Psych Central wrote an article about withdrawal from psych meds in response to an email exchange he and I had in which I encouraged him to cover the very serious issues with psychiatric drug withdrawal…well, the conversation has been started but the severity of the problem has simply not been addressed…for example he makes comments like, |
In some extreme cases, a specialist who focuses on helping people discontinue psychiatric drugs might prove helpful. |
As if such specialists existed…and as if difficult withdrawals were truly a rarity. They're not…they're simply not generally recognized by the prescribers. What's worse severe withdrawal is often blamed on the patient and explained away as "the underlying illness," the translation being that what is sometimes very severe and grave illness is all in the heads of the crazy person who was appropriately taking psych meds to begin with. The ensuing method of treatment is almost always more drugs which quite often further complicates and harms the patient. |
There are other problems with the article too…like the general assumption that psych drugs should be used to begin with or that there isn't rampant inappropriate prescribing happening all the time. These assumptions should be questioned pretty much always. There are many other ways of approaching the treatment and healing of mental health issues that are rarely addressed at all in standard mental health settings. |
For the numerous other ways to approach people in mental distress visit the drop-down menus at the top of this page. It's worth demanding options and finding people who know they exist. There are people who know a different way. Seek them out. The best time to do this is before becoming dependent on drugs. |
In any case, let's thank John Grohol for getting the conversation started and leave some comments about the reality on the ground. This is an opportunity to share your knowledge and experience in a community who desperately needs to know the truth. |
Read John Grohol's article here: Withdrawal from Psychiatric Meds Can Be Painful, Lengthy |
I'm also including Alto Strata's response to John. She's written several pieces worth reading on Beyond Meds too. You can see them collected here. |
Here is her response to Grohol from Withdrawal from Psychiatric Meds Can Be Painful, Lengthy |
Dr. Grohol, thank you for bringing this to the attention of Psych Central readers. |
In the recursive echo chamber that is psychiatric research, psychiatry has published many articles emphasizing that withdrawal symptoms are mild and last only a few weeks. This includes Kotzalidis, 2007 quoted above. |
(These papers also obtusely imply that withdrawal symptom patterns are idiosyncratic, rather identifying them as autonomic destabilization.) |
One of Kotzalidis, 2007′s central sources is researcher Peter Haddad, who is cited in almost all antidepressant withdrawal studies. |
In a 2001 paper, Dr. Haddad wrote: |
Most reactions are mild and short-lived and require no treatment other than patient reassurance. Severe cases can be treated symptomatically or the antidepressant can be reinstated before being gradually withdrawn. Reinstatement usually leads to symptom resolution within 24 hours. Some individuals require very conservative tapering schedules to prevent the re-emergence of symptoms. |
Author or co-author of many papers about antidepressant withdrawal, Dr. Haddad is always careful to say "usually" or "most" when it comes to sunny predictions about how long withdrawal syndrome takes to resolve, because he knows there are cases where it takes many months or even years to resolve. |
Haddad goes on to say: |
The "expert opinion" comes from U.S. committees underwritten in 1997 by Lilly (manufacturer of Prozac) and 2006 by Wyeth (manufacturer of Effexor). (Schatzberg and Haddad served on both committees.) |
"Expert opinion" about withdrawal syndrome, then, is molded, if not dictated, by commercial interests. |
In short, whatever medicine knows about antidepressant withdrawal syndrome is based on anecdotes collected by a few researchers, recycled throughout the entire body of literature on the subject. This reflects the doctors' opinions (possibly influenced by pharma consulting contracts), not the experience of patients. |
If you want to see patient experiences, hundreds of thousands of posts all over the Web report withdrawal syndrome lasting many months or years. |
I'm still recovering from my own withdrawal from Paxil in October 2004. |
On my peer support web site for tapering and withdrawal syndrome, SurvivingAntidepressants.org, there are many reports of prolonged withdrawal syndrome, as well as many more about difficulty in tapering. (Case histories may be read here) |
What's emerged is that, at the risk of destabilizing their nervous systems, some people need very gradual tapering taking months or years to go off psychiatric medications. |
If only people could find "a specialist who focuses on helping people discontinue psychiatric drugs"! I know of only a few such knowledgeable practitioners in the entire world. (I'm always looking for doctors who understand tapering to refer people to, if you know of such, please contact me through SurvivingAntidepressants.org.) |
Every doctor who prescribes psychiatric medication should be well-versed in tapering techniques. Few know anything. (Do NOT skip doses to taper!!!!) This is a disgrace to all of medicine. |
For more information and safer withdrawing tips on psychiatric drug withdrawal see: Psychiatric drug withdrawal 101 |
For support while withdrawing from psychiatric drugs see here: Support in withdrawal |
Both of the above posts include many links to additional information and resources. |
Some withdrawal stories: |
● Monica's story: the aftermath of polypsychopharmacology |
● Benzodiazepine withdrawal story. Through hell and out the other side |
● Pray, cry, scream, kick, write, whatever it takes, do not be silent, let it out. Benzodiazepine withdrawal recovery story |
● Withdrawal from antidepressant leads to spiral into polydrugging, until Molly realizes that drugs are the problem and emerges victorious<eot>Asking the Next Question: PW Talks with Sandra M. Odell |
In Godfall and Other Stories (Hydra House, Apr.), Odell assembles a kaleidoscope of voices. Each story brushes against multiple genres and is informed by the author's life. |
Harlan Ellison is perhaps the biggest influence, because when I first read him as a child he taught me that it was okay to be angry. Not hateful, not hurtful. It's not "I'm angry so I'm going to go kick sand in your face." No, it's being able to express that anger in a constructive manner. Being able to educate and entertain with it. So he is vital to my growth as a writer. Ursula K. Le Guin was an incredible influence. Octavia Butler, an incredible influence. Robert Frost—I have a copy of "The Road Not Taken" hanging on my wall. I see the world very differently, not only because I have whatever issues I have, but because I'm a writer. And having chosen to say, "This is what I want to do, this is how I express myself, this is my joy and my passion"—it's taken me down different roads. Some people ask, "Where you do you get your ideas?" All I want to do is look at them and say, "How can you not get ideas?" |
How have the ideas of inclusion and diversity influenced your writing? |
I hadn't realized growing up just how casually racist and sexist my family was. When I was better able to step back, I started to educate myself, and that was really my introduction to a wider world. If I am going to be a part of that world and help celebrate that world, celebrate issues that I consider important to me, then I need to learn. |
I don't want to read stories about me. I don't want to read the same stories written by the same people about the same issues in the same way. I want to celebrate your story. I want to celebrate my friends' stories. There are too many wonderful facets to this world to just say, "No, I only want to write straight white cis female stories." We also have to recognize our history and the damage that colonialism has done. |
What would you like readers to take away from the anthology? |
Ask the next question. Don't stop wondering. Don't stop asking. Always ask the next question. Theodore Sturgeon said that. I've got it tattooed on my arm. Ask the next question, and the one after that, and the one after that, until you understand. Too often people will only ask one question, or only ask questions until they get the answer they're looking for. That may not be what's really happening; that may not be the truth. Always ask the next question. |
A version of this article appeared in the 04/09/2018 issue of Publishers Weekly under the headline: Asking the Next Question<eot>Rose at rebel |
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- - Three Inch Drums (http://squarebirds.org/vbulletin/showthread.php?t=388) |
1960Bird 12-21-2004 09:11 PM |
Does anyone know if the front brakes, (3" shoes,drums and pistons etc.) from the Bulletbirds will fit on the squarebird front spindles? |
1rancher 12-22-2004 07:18 AM |
I read an article about the 1959 thunderbird nascar entry about 5 or more years ago where one of the modifications holoman / moody had done was to use spindles and brakes off a lincoln which had the 3 inch brakes. So as a guess i would say yes and that might be where the bullet birds get their brakes, (ford saving money). If anyone on this site has a list of the mods done to these cars i would sure enjoy seeing it posted. I have searched the net in the past but could not find a detailed list of the mods. I also read in the same article that durring that year one of the thunderbirds came out of the race due to frontend problems. |
mark...1960 thunderbird conv. |
flynbrian48 12-23-2004 08:14 AM |
As easy and cheap as it was to put the late 70's spindles/disk brakes on my '59, I'd think that'd be a better swap than the drums. Given that it seems the ball joints seem to be the same on all these, you could probably, if you have them, simply swap out the spindles and all if you're set on using the 3" drums. |
How does your modified 390 pull the 'Bird? I was a bit dissapointed with the 5.0 HO I put in mine. It's a bit lacking in the torque department. I guess I discounted the add'l weight of the 'Bird as opposed to the 87 Mustang GT the engine originally powered! I didn't think it'd be that much heavier, but, it's still probably almost half a ton more. Steeper gears would help me, as I have the AOD trans. |
I'd originally planned on a supercharger for the 5.0, but other projects have sidelined hot rodding this engine. |
1rancher 12-23-2004 09:07 AM |
1960Bird 12-23-2004 10:18 AM |
The car pulls pretty good, if it is running good, I have some carb issues yet to be corrected) The engine is a a 1961 block and heads, it also has a mild cam along with the rest of the stuff I have listed. She will spin the tires pretty easily, although, if I had a C-6 rather then my old "Cruise O" it would be a lot better, I really need about a 2200 RPM torque converter to get the power down. As they used to say "HP sells cars...torque wins races" The big blocks have the torque that is for sure. I would guess that my new engine has about 325 actual HP and around 425 ft. lbs torque. |
As for the brake switch over...I already have everything to do a 11 inch Granada disc switch, except a good proportioning valve. Being very lazy...I thought if I could just go to the bigger drums/shoes it would be a lot easier job. I estimated that I would pick up about 20% more front brake shoe surface area. If the 3' brakes stopped the 4400 pound Bulletbirds OK they should stop my old Squarebird on a dime. |
1960Bird 12-23-2004 11:51 AM |
RE: Brian Three Inch Drums |
I got to thinking about your car after my last post. Assuming that you are looking for more performance. |
Since you have a 302 with AOD why not switch your rear end to a 4.11. That would give you some get up and go plus take advantage of you 302 engines higher RPM's capabilities. With the AOD you would still be OK for highway driving. JMHO<eot>Christopher Avery | Mission 38—Can you hear me now? Wireless exec introduces 100 managers to Responsibility Redefined |
Mission 38—Can you hear me now? Wireless exec introduces 100 managers to Responsibility Redefined |
I'm the VP now and I get to decide what messages my people hear |
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