content
stringlengths
0
1.88M
url
stringlengths
0
5.28k
Email: [email protected] Phone: +61-730-407-305 Follow Us On: My Account Home Our Services Homework Help Management Assignment Help Accounting Assignment Help Cost Accounting Assignment Help Balance Sheet Assignment Help Bond Assignment Help Cash Basis Assignment Help Cash Flow Statement Assignment Help Common Stock Assignment Help Comprehensive Income Assignment Help Economics Assignment Help Consumer Behaviour Assignment Help Banking Assignment Help Anglo Saxon Economy Assignment Help Help With Assignment Finance Assignment Help Contact Us Recent Questions Review / Rating Live Chat Home Recent Questions Question #43229 Man181013164 Recent Question/Assignment Description: Written Report The purpose of this final assessment task to draw together your learning throughout the course and to demonstrate in the report how you will apply your knowledge and skills. This task gives you the opportunity to consider how a positive contribution can be made in alignment with the United Nations Sustainable development goals. This is consistent with the UN's Principles of Responsible Management Education (PRME): -Business and management schools play a key role in shaping the skills and mindsets of future business leaders, and can be powerful drivers of corporate sustainability.- [see: https://www.unglobalcompact.org/take-action/action/management-education.] There is a wide range of contexts for you to choose from. It is suggested you chose a goal that aligns best with your career endeavours. It is our hope that one day you will be in a position to participate in business at all levels of management and specifically at the level of strategic managers and board of directors. Resources Report is to be done individually. It is required to be a minimum of 2500 words. To ensure the correct formatting of the report, students must complete and submit the Style Guide checklist. Read these closely and apply it. The checklist is an interactive PDF. This document does not require an Executive Summary, Authorisation, Scope or Limitations sections. It is required that students submit the written report and that it is written to an acceptable University standard of English. Rubric Download attached document for details on assessment task and marking criteria Looking for answers ? Recent Questions All problems need full detailed working MITS4002 OBJECT-ORIENTED SOFTWARE DEVELOPMENT Project (25%) Tattslotto50% deduction for Late Submission within one week 0 mark for Late Submission more than one week 0 mark for duplicated Submission or... The following questions are based on the material Module 1 of the textbook:Question 1Briefly explain the purpose of each of the following types of ICT Audit.1.1 Critical System Audit1.2 Desktop Software... HOLMES INSTITUTE FACULTY OF HIGHER EDUCATION Assessment Details and Submission Guidelines Trimester T1 2019 Unit Code HI5002 Unit Title Finance for Business Assessment Type Group Assignment Assessment... HOLMES INSTITUTEFACULTY OFHIGHER EDUCATIONAssessment Details and Submission GuidelinesTrimester T1 2019Unit Code HI6008Unit Title Business Research ProjectAssessment Type 4. Reflective Journal (Individual)Assessment... MITS4002OBJECT-ORIENTED SOFTWARE DEVELOPMENTProject (25%)Tattslotto50% deduction for Late Submission within one week0 mark for Late Submission more than one week0 mark for duplicated Submission or Shared... For questions due week 5Market Research (Chapter 4).1. You are a marketing manager for a large University in Australia. The organisation has stated their enrolments are down in regional areas. Develop...
https://www.australiabesttutors.com/recent_question/43229/description-written-reportthe-purpose-of-this-final
Security researchers have found a privilege escalation vulnerability in pkexec, a tool that’s present by default on many Linux installations. The flaw, called PwnKit, could allow attackers to easily gain root privileges on systems if they have access to a regular user without administrative privileges. Researchers from security firm Qualys who discovered and reported the vulnerability were able to confirm it is exploitable in default configurations on some of the most popular Linux distributions including Ubuntu, Debian, Fedora and CentOS. They believe others are likely impacted as well, since the vulnerable code has existed in pkexec since the tool’s first version, over 12 years ago. To read this article in full, please click here More Stories ConnectWise Fixes XSS Vulnerability that Could Lead to Remote Code Execution Threat actors could exploit the flaw to take complete control of the ConnectWise platform Read More Google Releases Chrome Patch to Fix New Zero-Day Vulnerability The high-severity vulnerability refers to a heap buffer overflow in the GPU component Read More Remote Code Execution Vulnerability Found in Windows Internet Key Exchange The discovered vulnerabilities could have been exploited to target almost 1000 systems Read More What is Antivirus and What Does It Really Protect? Authored by Dennis Pang What is antivirus? That’s a good question. What does it really protect? That’s an even better... Cybercriminals are increasingly using info-stealing malware to target victims Cybercriminals are increasingly shifting from automated scam-as-a-service to more advanced info stealer malware distributors as the competition for resources increases,...
https://cybersecurityupdate.net/news/serious-pwnkit-flaw-in-default-linux-installations-requires-urgent-patching/
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a temperature compensation system, and more particularly to a temperature compensation system used for a photo-taking lens made principally of plastic. 2. Description of the Prior Art The position of the image point of a photo-taking lens made mainly of plastic fluctuates considerably with changes in temperature. Consequently, it is necessary to perform a correction in response to the changed temperature such that the image point becomes located at a prescribed position. Since the fluctuation in the position of the image point caused by the change in temperature is manifested as a fluctuation of the lens back, a means to measure the temperature as well as a means to correct the lens position is needed in order to compensate for the fluctuation of the lens back. As a system equipped with these means, a temperature compensation system in which corrections are made to the camera's control data using a temperature measuring device located inside an IC (integrated circuit) has been proposed in Japanese Laid- Open Patent Hei 4-43310. Further, where the photo-taking lens made mainly of plastic is a zoom lens, the degree of fluctuation of the lens back due to a change in temperature varies from one focal length to another, as a result of which it is particularly important how the correction Is performed in response to the change in temperature. As a temperature compensation system used for a zoom lens, constructions in which the compensation for the fluctuation of the lens back is performed by means of correction of the lens drive mount, as proposed in Japanese Laid-Open Patent Sho 59- 160107, and in which the compensation for the fluctuation of the lens back takes place during the focusing process based on the degree of change in temperature from the preset in-focus status, as proposed in Japanese Laid- Open Patent Hei 3-181924, have been proposed. In addition, a construction in which the distance measurement data is corrected based on the temperature measurement data has also been proposed in Japanese Laid-Open Patent Hei 4-320206. Further, although not applicable to a zoom lens construction, a construction in which the degree of change in magnification is calculated from the degree of change in focal length caused by a change in temperature, and focus adjustment is thereupon performed based on this calculation result, has been proposed in U.S. Pat. No. 5,124,738. Such compensation for the fluctuation of the lens back is needed when the camera has high image formation magnification for short-distance photo- taking (as in the case of photoengraving cameras, etc.). An IC is not ordinarily located in the photo-taking lens barrel. Therefore, where temperature measurement is performed using an IC in the camera body, as in Japanese Laid-Open Patent Hei 4-43310, if the camera's ambient temperature changes markedly and suddenly, the temperature at the temperature measurement point cannot keep pace with the temperature of the photo-taking lens, leading to a large error in temperature measurement, which consequently gives rise to the problem that the temperature of the photo-taking lens cannot be measured correctly. In addition, a construction in which a delay in response is compensated for by means of predicting the tendency of change in temperature of the photo- taking lens based on the output of a temperature detection sensor is proposed in Japanese Laid-Open Patent Hei 4-73627, but it is still difficult to predict the temperature with accuracy where the change in temperature is marked and sudden. On the other hand, in Japanese Laid-Open Patents Sho 59-160107, Hei 3- 181924 and Hei 4-320206 and U.S. Pat. No. 5,124,738, because temperature compensation is performed without reference to the zooming or adjustment of the lens, and correction of the image point position is not directly performed based on the focal length, the fluctuation of the lens back cannot be accurately compensated for. SUMMARY OF THE INVENTION The present invention was developed in regard to said situation. Its object is to provide a temperature compensation system for the photo- taking lens capable of performing accurate correction such that the image point, which fluctuates as the temperature of the photo-taking lens changes, can be moved to a prescribed position. In order to achieve said object, the first invention disclosed in this application involves a system which is mounted in a camera capable of detecting a focal point and which performs temperature compensation with regard to the focal point detection data, wherein said system is located inside the photo-taking lens barrel and comprises a sensor or sensors that output electric signals corresponding to the temperature inside the lens barrel, a temperature measuring means that outputs temperature data regarding the interior of the photo-taking lens barrel based on the output signals from said sensor or sensors, and a correcting means that makes corrections to the focal point detection data based on the temperature data output from said temperature measuring means. It is desirable that the temperature measurement be performed in certain areas of the camera, such as in lenses sensitive to ambient change in temperature (plastic lenses), or in the area inside the lens barrel falling outside the top one-quarter of the lens barrel defined by a 90-degree arc radiating from the optical axis and facing upward. Further, the second invention disclosed in this application involves a system that is mounted in a camera capable of detecting a focal point and that performs temperature compensation with regard to the focal point detection data, wherein said system comprises a means to detect the focal length of the photo-taking lens, a means to measure the temperature of said photo-taking lens, a means to calculate the degree of correction based on said detected focal length data and temperature data, and a means to make corrections to the focal point detection data based on the degree of correction calculated by said calculating means. Furthermore, it is preferable that the system have a means to detect the object distance so that the object distance data is added as one parameter for the calculation of the degree of correction, as well as that the focal point detection data be corrected based on the focal length, object distance and temperature information. By virtue of said construction, in the first invention of this application, since the focal point detection data is corrected based on the temperature data measured by the temperature measuring means that measures the temperature of the interior of the photo-taking lens barrel, the temperature of the lens elements comprising the photo-taking lens may be accurately measured even if, for example, the camera's ambient temperature has changed markedly and suddenly, allowing appropriate temperature compensation. In addition, using the second invention, the focal point detection data is corrected based on not only the temperature data but also on the photo-taking lens's focal length data, which allows appropriate temperature compensation even if, for example, the photo- taking lens's focal length has changed. The object and features of the present invention, which are believed to be novel, are set forth with particularity in the appended claims. The present invention, both as to its organization and manner of operation, together with further objects and advantages, may best be described in connection with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional view showing the outline construction of a camera In which the first embodiment of the present invention is used. FIG. 2 is an illustration showing the construction of a zoom lens which may be used in the first embodiment of the present invention. FIG. 3 is a cross-sectional view showing a different arrangement for mounting the temperature sensors that may be employed in the first embodiment of the present invention. FIG. 4 is an illustration showing the points at which the temperature may be measured in order to check the temperature distribution in a camera in which the first embodiment of the present invention is used. FIG. 5 is a graph showing the change in temperature inside the camera body when the camera shown in FIG. 4 is cooled suddenly. FIG. 6 is a graph showing the change in temperature of the photo- taking lens system when the camera shown in FIG. 4 is cooled suddenly. FIG. 7 is a graph showing the change in temperature of various parts of the lens barrel when the lens barrel which may be used in the first embodiment of the present invention receives direct sunlight. FIG. 8 is a cross-sectional view of the lens barrel showing the area susceptible to the influence of change in temperature when direct sunlight is received. FIG. 9 is a block diagram showing the outline construction of the camera in which the second embodiment of the present invention is used. FIG. 10 is a flow chart showing the process followed for calculation of the lens drive amount in the second embodiment of the present invention. FIG. 11 is a graph showing the relationship among the temperature, the focal length and the degree of compensation for the fluctuation of the lens back in the second embodiment of the present invention. FIG. 12 is a graph showing the relationship among the object distance, the focal length, the temperature and the degree of compensation for the fluctuation of the lens back in the second embodiment of the present invention. FIG. 13 is a drawing showing the process followed for calculation of the reference lens drive amount Kf in the second embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention are described below with reference to the drawings. First, the first embodiment of the present invention is explained. As described above, because the position of the image point of a zoom lens made mainly of plastic fluctuates easily with a change in temperature, it is necessary to perform accurate corrections so that the image point is placed at a prescribed position. The first embodiment is characterized in that it is equipped with a temperature detecting sensor or sensors that measure the temperature inside the photo- taking lens barrel such that the image point position may be corrected based on the measured temperature. FIG. 1 is a cross-sectional view of a lens shutter camera containing a photo-taking lens in which the first embodiment is employed, and shows said camera's construction. This photo-taking lens comprises a two-unit zoom lens system. The first unit is affixed to first unit lens holder 3 and the second unit is affixed to second unit lens holder 4. Cams used for driving the first and second units are located on fixed lens barrel 5: the units are driven by the rotation of first moving lens barrel 1 on which the first unit is supported and that of second moving lens barrel 2 on which the second unit is supported, respectively. Shutter 7 is placed in front of the second unit. In this drawing, 6 is the surface of the camera body, FL is the film surface, TB is the lens barrel, and BD is the camera body. The first embodiment has a construction in which temperature sensor SE is located in lens barrel TB and the temperature of the photo- taking lens is indirectly measured by measuring the temperature of the interior of the lens barrel. Compensation for the fluctuation of the lens back is performed based on the temperature measured by temperature sensor SE. In addition, it is preferable that temperature sensor SE be located in the area around a lens element which exerts the largest influence in the shift of the image point (fluctuation of the lens back) caused by the change in temperature. In the first embodiment, second lens element G2 acts as such a lens element. Where temperature sensor SE is located near second lens element G2, even if the camera's ambient temperature changes markedly and suddenly, the temperature of the photo- taking lens that causes the image point shift is accurately reflected in the compensation for the fluctuation of the lens back, and as a result, compensation for the fluctuation of the lens back due to the change in temperature may be accurately performed. Numerical data regarding another zoom lens system which may be used in the first embodiment is shown below. Incidentally, ri (i=1,2,3, . . . ) represents the radius of curvature of an ith lens surface from the object side, di (i=1,2,3, . . . ) represents an ith axial distance from the object side, and Ni (i=1,2,3,...) and vi (i=1,2,3,...) represent the refractive index and Abbe number with regard to the d-line of an ith lens from the object side, respectively. Furthermore, f represents the focal length of the entire system and FNO represents the minimum F-number. Incidentally, in the numerical data, the surfaces marked with asterisks in the radius of curvature column are aspherical, and are defined by the following equation which represents the surface configuration of an aspherical surface. ##EQU1## In said equation, X represents an mount of displacement from the reference surface along the optical axis; r represents a paraaxial radius of curvature; h represents height in a direction vertical to the optical axis; Ai represents an ith- order aspherical coefficient; and &egr; represents a quadratic surface parameter. ______________________________________ f = 38.0˜47.8˜60.0 FNO = 4.4˜5.6˜7.0 r1* = 32.156 d1 = 3.400 N1 = 1.58340 &ngr;1 = 30.23 (polycarbonate lens) r2* = 11.345 d2 = 1.420 r3 = 22.877 d3 = 5.550 N2 = 1.52510 &ngr;2 = 56.38 (polyolefine lens) r4 = -12.028 d4 = 1.000 r5 = ∞(aperture) d5 = 11.392˜7.102˜3.688 r6* = ∞ d6 = 2.750 N3 = 1.52510 &ngr;3 = 56.38 (polyolefine lens) r7 = 145.850 d7 = 7.250 r8 = -9.727 d8 = 2.500 N4 = 1.52510 &ngr;4 = 56.38 (polyolefine lens) r9 = -23.453 ______________________________________ Aspherical surface coefficients r1:&egr;=0.10000×10 A4=-0.38294×10.sup.-3 A6=-0.51809×10.sup.-7 A8=0.23184×10.sup.-8 A10=0.25235×10.sup.-10 r2:&egr;=0.10000×10 A4=0.37362×10.sup.-3 A6=0.12697×10.sup.-5 A8=0.98113×10.sup.-8 A10=0.41149×10.sup.-11 r6:&egr;=0.10000×10 A4=0.60112×10.sub.-4 A6=-0.20624×10.sub.-6 A8=0.90545×10.sub.-10 A10=-0.44973×10.sub.-10 FIG. 2 is a cross-sectional view showing the construction of said zoom lens system, and shows the positions of lens elements in the shortest focal length condition. This zoom lens system is comprised entirely of plastic: first lens element G1 is comprised of polycarbonate, while second lens element G2, third lens element G3 and fourth lens element G4 are comprised of polyolefine resin. This zoom lens system comprises, from the object side, first lens unit Gr1 having negative meniscus lens element G1 concave to the image side, positive bi-convex lens element G2 and aperture stop S, and second lens unit Gr2 having plano-concave lens element G3 concave to the image side and negative meniscus lens element G4 concave to the object side. Both surfaces of negative lens element G1 and the object side surface of plano- concave lens element G3 are aspherical. Incidentally, aperture stop S operates as an aperture and a shutter. Where it is assumed that the degree of change of the refractive index caused by the change in temperature is &Dgr;n/&Dgr;T=-10× 10. sup.-5 for both polycarbonate and polyolefine resin, the relationship among the lens elements in terms of the influence exerted over the degree of fluctuation of the lens back &Dgr;LB caused by the change in temperature is shown as &Dgr;LB.sub.(G1) :&Dgr;LB.sub.(G2) :&Dgr; LB.sub. (G3) :&Dgr;LB.sub.(G4)=- 0.35:1:-0.13:-0.04, assuming the influence exerted by second lens element G2, which has the largest influence (to be described below with reference to Table 1), to be 1. FIG. 3 shows another example of the arrangement of temperature sensors SE. As shown in this drawing, concave units V are located on the edge surfaces of the lens and temperature sensors SE are inserted in them. The temperature of lens element G2 is directly measured with temperature sensors SE in contact with second lens element G2. Such an arrangement of temperature sensors SE can further increase the accuracy of the measurement. While in this example temperature sensors SE are attached to second lens element G2 which is most influenced by a change in temperature, the lens element whose temperature is to be measured may be selected as needed. Incidentally, temperature sensors SE may be affixed to the lens upon insertion by using an adhesive. For temperature sensor SE, a thermistor (a resistor sensitive to heat) may be employed. Because the resistance of the thermistor varies depending on the temperature, the measured resistance may be converted into temperature. Further, while temperature sensors SE are located at two points in FIG. 3, the number of temperature sensors need not be limited to one or two: by having two or more temperature sensors SE around a single lens or on two or more lenses, accurate temperature measurement, including that of the temperature distribution of the entire system, becomes possible. Next, the change in temperature distribution inside lens barrel TB and camera body BD when the temperature suddenly changes, as well as the variation in the accuracy of the correction depending on the location of temperature sensor SE, was investigated as explained below. Camera body BD shown in FIG. 4 was employed as a jig and its ambient temperature was caused to drop to -10° C. from room temperature (26° C.) (in other words, the temperature outside lens barrel TB was suddenly changed from 26° C. to -10° C.). The change in temperature inside camera body BD and the change in temperature inside lens barrel TB were measured at prescribed positions and the results are shown in FIG. 5 and FIG. 6, respectively. Incidentally, the zoom lens system shown in FIG. 2 was used as the photo-taking lens system in lens barrel TB. Further, glass barrier BR was placed on the object side of lens barrel TB. The points where the temperature was measured were point G1NO1 on the object side of first lens element G1, point G1NO2 on the image side of second lens element G2, point G1Air in the layer of air between first lens element G1 and second lens element G2, point G4NO2 on the lens surface on the image side of fourth lens element G4 and point G4Air in the layer of air on the image side of fourth lens element G4. Inside camera body BD (PO (=10 mm) away from lens barrel TB), the points used were depths dA (=2 mm), dB (=10 mm) and dC (=17 mm) from the inner wall of outer body 6 toward the inside of camera body BD along optical axis AX. From the measurement results (FIGS. 5 and 6), it was learned that there is a maximum 10° C. difference in temperature between G1, which is located at the top of the lens system, and G4, which is located at the end of the lens system, that temperature varies greatly depending on the difference in the thickness of layer of air inside camera body BD- -there is a maximum 15° C. difference with a 15 mm thick layer of air- -and that it requires approximately 40 minutes for the temperature of the entire lens system to become uniform. In addition, based on the temperature measurement data shown in FIGS. 5 and 6, the largest balance of compensation at each temperature measurement point was calculated and the results are shown in Table 1. This largest balance of compensation refers to the largest of the lens back fluctuation amounts for the entire photo-taking lens system calculated based on the difference between the temperature at a reference point and the temperature of each lens element when the ambient temperature is suddenly changed from a certain level, as well as the simulated lens back fluctuation mount of each lens element resulting from a change in temperature. Said lens back fluctuation mount of each lens element resulting from a change in temperature represents the degree of influence that each lens element exerts over the lens back fluctuation [of the entire system] per one degree Centigrade, and may be calculated in advance via simulation. The lens back fluctuation mount of the ith lens element Gi resulting from a change in temperature is shown as &Dgr;G.sub.i below. The simulated lens back fluctuation mount &Dgr;G.sub.i for each lens element of the photo-taking lens in FIG. 2 is shown below. From these simulation values, it is clear that lens back fluctuation mount . DELTA.G. sub.2 for second lens element G2 resulting from a change in temperature is the largest. &Dgr;G.sub.1 =0.02 mm/° C. &Dgr;G.sub.2 =-0.06 mm/° C. &Dgr;G.sub.3 =0.003 mm/° C. &Dgr;G.sub.4 =0.01 mm/° C. Said largest balance of compensation was calculated as explained below. First, it was assumed that there is linearity in the tendency of the change in temperature based on the actual measurement results shown in FIGS. 5 and 6 (for example, the tendencies of change in temperature at temperature measurement points G1NO1 and G4Air). Then, the temperature of first lens element G1 (T.sub.1), that of second lens element G2 (T.sub.2), that of third lens element G3 (T.sub.3) and that of fourth lens element G4 (T.sub.4) were predicted from these graphs. Temperature measurement points corresponding to these predicted temperatures, the points in the layer of air between first lens element G1 and second lens element G2 (G1Air) and the temperature measurement points in the camera body at depth dB (=10mm) and depth dC (=17 mm) were deemed as the reference points. Then, taking as the reference point one of the temperature measurement points corresponding to the predicted temperatures (T.sub.1, T.sub.2, T. sub.3, T.sub.4) for the lens elements, the points in the layer of air (G1Air) between first lens element G1 and second lens element G2 and the temperature measurement points in the camera body (dB, dC), the differences &Dgr;t.sub.i between the temperature at that reference point, and the predicted temperatures for other lens elements Gi, were obtained. These temperature differences &Dgr;t.sub.i are, if the temperature measurement point for third lens element G3 is deemed to be the reference point, &Dgr;t.sub.1 =T.sub.1 -T.sub.3, &Dgr;t.sub.2 =T. sub. 2 -T.sub.3, and &Dgr;t.sub.4 =T.sub.4 -T.sub.3. The addition of the products of said lens back fluctuation amount . DELTA.G.sub.i due to a change in temperature and the temperature difference &Dgr;t.sub.i for each lens element is the compensation balance. For example, if the temperature measurement point for third lens element G3 is deemed to be the reference point, the compensation balance will be &Dgr;G.sub.1 &Dgr;t.sub.1 +&Dgr;G.sub.2 &Dgr;t. sub.2 +. DELTA.G.sub.4 &Dgr;t.sub.4. Table 1 shows the largest balance of compensation from among the compensation balances for each temperature measurement point at various measurement times. From these results, it is seen that accuracy in compensation varies depending on the temperature measurement point. It is further seen that the target temperature compensation cannot be achieved unless the temperature inside lens barrel TB is measured, and that compensation for the fluctuation of the lens back can be performed quite accurately even after a sudden change in temperature if the temperature of second lens element G2 is measured, because the temperature of second lens element G2 has the largest influence over the shift of the image point. TABLE 1 ______________________________________ Reference point (measurement point) Largest balance of compensation ______________________________________ Inside camera body, dB (10 mm) 1.5 mm Inside camera body, dC (17 mm) 2.9 mm G1 0.1 mm Layer of air between G1 and G2 0.05 mm G2 0.01 mm G3 0.1 mm G4 0.2 mm ______________________________________ The change in temperature inside lens barrel TB (FIG. 4) caused by direct sunlight is explained below with reference to FIG. 7. Temperature sensors SE are placed around second lens element G2 (FIG. 4) inside lens barrel TB (four points: top, bottom, left and right). The change in temperature when direct sunlight is received from the upper left of lens barrel TB in the longest focal length condition was measured, the result of which is shown in FIG. 7. From the measurement result shown in FIG. 7, it was learned that there is an approximately 10° C. maximum temperature differential between the side on which the sun shines (the upper left side of lens barrel TB) and the opposite side (the lower right side of lens barrel TB) and that the degree of compensation for the fluctuation of the lens back varies significantly depending on which point is used for the measurement. In order to deal with this difference in temperature, the constructions described below may be used. In the first construction, temperature sensors SE are placed inside lens barrel TB such that the temperature is measured at four points, i.e., top, bottom, left and right, and the compensation for the fluctuation of the lens back is performed using the average of the measurement results for the four temperature sensors SE. The second construction is a construction which does not perform temperature measurement in areas where there is a marked and sudden change in temperature. FIG. 8 shows a cross-section of lens barrel TB, and &thgr;1 is an area where the change in temperature is marked due to direct sunlight, while &thgr;2 is an area where the change in temperature caused by direct sunlight is not marked. Temperature sensors SE may be placed in area &thgr;2. Where the temperature of the lens barrel changes due to its receiving direct sunlight, the temperature in the vicinity of the surface of the lens barrel on which the sun shines (area &thgr;1) changes markedly and suddenly, As a result, the difference between this temperature and the temperature of the photo-taking lens system itself becomes large. Therefore, if the temperature measured in area &thgr;1 is employed, the temperature of the photo-taking lens itself, which is the cause of the shift of the image point, is not properly reflected in the compensation for the fluctuation of the lens back. In order to properly compensate for the fluctuation of the lens back, it is desirable to employ an average temperature as in said first construction: however, if temperature measurement in the area where the temperature markedly and suddenly changes due to direct sunlight is avoided, a measurement value closer to the true temperature of the photo- taking lens may be obtained. For example, during the daytime, when there is strong sunlight, . theta.1=90° and &thgr;2=270° in FIG. 8. If the temperature in the area outside the 90° area (=&thgr;1) facing upward inside lens barrel TB, i.e., &thgr;2, is employed as the temperature to be used in connection with the compensation for the fluctuation of the lens back, the error in temperature measurement due to the effect of the sunlight may be reduced. A second embodiment in which compensation for the shift of the image point (degree of fluctuation of the lens back) caused by a change in temperature is performed is explained below. The second embodiment is characterized in that the temperature compensation is performed in a zoom lens system using such parameters as the focal length and object distance. In other words, the characteristics lie in the method of compensation in which the lens drive compensation mount is calculated based on the temperature and focal length or the temperature and object distance and in which the correction of the image point position is performed based on said result. Due to the construction in which the temperature compensation is performed using the object distance and the focal length as described above, highly accurate focus adjustment may be achieved even where the focal length has changed. In addition, because the lens drive compensation amount is calculated using the object distance data in addition to the temperature and focal length data as calculation parameters, correction with higher accuracy may be performed. FIG. 9 shows an outline construction of a camera in which the present invention is applied. Zoom encoder ZE detects the focal length of the photo-taking lens (the zoom lens system shown in FIG. 2). Temperature sensor SE measures the temperature of the photo-taking lens. Microcomputer 10 calculates the lens drive compensation amount as to first lens unit Gr1 based on focal length f and temperature T, and then regulates the correction of the position of image point of the photo- taking lens based on the result of this calculation. Incidentally, 12 is an FA module and FL is the film surface. In this system, shifting of the first lens unit (shifting for focusing and compensation for the fluctuation of the lens back) is achieved using focusing motor FM. The lens drive operation is regulated by pulse encoder PE which counts the increments of shifting of first lens unit Gr1. In other words, microcomputer 10 monitors the amount of shift of first lens unit Gr1 by means of the PI information from pulse encoder PE (`PI monitor` in FIG. 9) and regulates the amount of shift of the first lens unit based on the result of said monitoring. Focal length f is detected by incorporating the amount of shift of second lens unit Gr2 into microcomputer 10 by means of zoom encoder ZE. Temperature sensor SE is located inside the lens barrel, and as described above, it is preferable to place it near second lens unit Gr2 to increase measurement accuracy. The operation for calculating drive amount L is explained in accordance with the flow chart shown in FIG. 10. When a trigger signal is given to microcomputer 10 by turning the release switch ON, for example, microcomputer 10 obtains temperature information T from temperature sensor SE (#10). Then, by performing correction by means of adding temperature compensation value &agr; (T) to object distance information D' obtained from AF module 12, true object distance D is calculated (#20). The correction using temperature compensation value &agr; (T) will now be explained. In the active AF system, light is shed upon the object using a light-projecting LED (light emitting diode) and information regarding the object distance is obtained based on the position of the reflected light that returns to the light-receiving sensor. A change in temperature causes a discrepancy in the object distance information because the distance between the light-projecting LED and the light- receiving sensor or the distance between the lens of the light-projecting LED and the lens of the light-receiving sensor changes from one temperature to another. Therefore, the true object distance can be expressed by the following equation (F1). ##EQU2## In this equation, AH represents the location of the reflected light on the light-receiving sensor (the distance from a prescribed reference position); &Dgr;AHt represents the mount of shift due to the temperature change (known value obtained by actual measurement or simulation); and &agr; represents a coefficient to convert the position on the sensor into object distance. As shown above, compensation for the fluctuation of the lens back may be performed with higher accuracy by separately performing a calculation to correct the object distance in connection with AF module 12. In addition, a construction in which the calculation of the temperature compensation value &agr; (T) used in the calculation of object distance D is performed separately based on the temperature measured by a temperature sensor different from temperature sensor SE and located near AF module 12 may also be employed. In this construction, the quality of the camera (confirmation of the object distance information, etc.) can be checked for the lens block and the AF block separately, allowing easy resolution of the problems in connection with the respective blocks. In other words, if temperature compensation is performed accurately for the AF block, it may be easily determined whether the distance detected for the lens block is accurate. Next, lens back fluctuation compensation value &Dgr;L is calculated from focal length information f obtained from zoom encoder ZE, temperature information T and object distance information D described above (#30). Then, lens drive amount L is calculated by adding lens back fluctuation compensation value &Dgr;L to room temperature (20° C. ) lens drive amount L(20) (#40). As described above, because microcomputer 10 calculates the lens drive compensation amount for first lens unit Gr1 based on focal length f detected by zoom encoder ZE and object distance information D' detected by AF module 12, even where focal length f of the photo-taking lens has changed, the correction of the image point position necessitated by a change in temperature may be accurately performed in accordance with said focal length f. In this way, the accuracy of focusing is improved. The method of calculation of said lens drive amount L is explained below. FIGS. 11 and 12 show the relationship among the temperature, focal length and object distance in terms of the compensation amount for the fluctuation of the lens back (simulated value employing the zoom lens system in FIG. 2). In other words, FIG. 11 shows lens drive amount L for first lens unit Gr1 required in order to move the position of the image point, which fluctuates with the change of temperature of the zoom lens system, to a prescribed position with regard to each focal length f (the longest, middle and shortest focal lengths) when the object is at the infinity position (D=∞). FIG. 12 shows lens drive amount L for first lens unit Gr1 required in order to move the position of the image point, which fluctuates with the change of object distance D (in this drawing, the lateral axis represents 1/D), to a prescribed position with regard to each focal length f (the longest, middle and shortest lengths) as well as each temperature (-10° C., 0° C., 10° C., 30° C., 40° C., 50° C.). In these drawings, TELE (T) means the longest focal length condition (f=38.0), MIDDLE (M) means the middle focal length condition (f=47.8) and WIDE (W) means the shortest focal length condition (f=60.0). Further, in regard to the PI numbers on the vertical axis, positive numbers indicate movement in the direction of the image side (the direction of shift of the lens toward infinity from the closest object position). These PI numbers represent the lens drive mount for first lens unit Gr1, and the PI monitoring regarding the lens drive mount takes place using the pulses intermittently sent from pulse encoder PE (FIG. 9), in which one pulse count is interpreted as 1 PI (1 PI approximates to 4. 4 &mgr; m). It can be seen from FIGS. 11 and 12 that the degree of the fluctuation of the lens back varies depending on the degree of change in temperature T0-T (T0 represents the reference temperature while T represents the measured temperature), focal length f and object distance D, respectively. Therefore, in the calculation of lens drive mount L, first, focal length f is divided into three zones and the compensation for the fluctuation of the lens back is performed for each zone. Second, because the fluctuation of the lens back due to the change in temperature (T0-T) takes place in a linear fashion, the correction is performed via linear interpolation. Third, while the fluctuation of the lens back due to the change of object distance D takes place in a linear fashion, since the degree of fluctuation is small, the object distance is divided into zones and the compensation for the fluctuation is performed using constants. Lens drive amount at 20° C. L(20) is expressed by a PI number which indicates zooming of the lens from the reference position (namely, the closest object position) toward the infinity position. Zooming toward the infinity position here means that the focusing lens (first lens unit Gr1) is moved such that the camera becomes focused on an object located at infinity. The infinity position refers to the position that requires the smallest lens drive amount, and the closer the object is, the more the lens is zoomed to the object side. Because the position at which the lens is maximally zoomed out (the infinity position) is the initial position in this system, the larger the object distance is, the more first lens unit Gr1 needs to move toward the image side. Lens drive amount L(20) is obtained by using one of the different zones for focal length f and object distance D and by performing linear interpolation via the following equation (1). L(20)=Pij×SP/16+Qij+Kf (1) In this equation, i represents one of the three object distance zones (far, middle or close); j represents one of the three focal length zones (telephoto, middle or wide); Pij represents the gradient coefficient for each object distance and focal length zone (=a constant: multiplied by 16 in order to obtain an integer value); SP represents the step number for the object distance (the object distance ranges from 0. 598 m to infinity and is divided into steps 0 to 129); Qij represents the constant for each object distance and focal length zone; and Kf represents the reference lens drive amount (the number of PIs from the initial lens position to the closest object position). Lens drive mount &Dgr;L when the temperature has changed from 20. degree. C. to measured temperature T is obtained by using one of the different zones for temperature T and focal length f as well as temperature T and object distance D, and then providing relevant constants and performing linear interpolation via the following equation (2). &Dgr;L=L(T)=Xej×(T0-T)/16+Yej+Zie (2) In said equation, e represents one of the three zones of temperature (low temperature, room temperature or high temperature); j represents one of the three focal length zones (telephoto, middle or wide) ; Xej represents the gradient coefficient for each temperature and focal length zone (=a constant: multiplied by 16 in order to obtain an integer value); T represents the measured temperature; T0 represents the reference temperature (=10° C.); Yej represents the constant for each temperature and focal length zone; and Zie represents the compensation value for each object distance and temperature zone. Said reference temperature T0 was determined in order to facilitate the calculation of the compensation value. This was determined to be 10. degree. C. so that the change in temperature(T0-T) does not change from positive to negative or vice versa. In addition, said Zie is determined based on the temperature and object distance as shown in the map in Table 4, described below. This map was obtained from the graph in FIG. 12 showing the relationship between object distance D and measured temperature T, taking allowable levels into consideration. The total lens drive amount L is the addition of said L(20) and L(T), and is obtained using the following equation (3). L={Pij×SP+Xej×(T0-T)}/16+Qij+Yej+Zie+Kf (3) Said constants are stored in the camera EEPROM (not shown in the drawings). Maps for the calculation are shown in the following Tables 2 through 4. While compensation based on the object distance is performed using the constant Zie in the maps, it may also be carried out using linear interpolation, as when the compensation is done based on the focal length. Incidentally, because the data regarding the object distance and temperature (measurement results according to 1° C. increments) is digitally constructed, the borders between zones do not overlap (digital resolution). In addition, because the focal length is divided into three zones by virtue of the ON and OFF switching information of zoom encoder ZE, the borders between zones overlap. Since linear interpolation is employed in the compensation for the fluctuation of the lens back as described above, the EEPROM should hold only coefficient data, which helps reduce the size of the ROM. Incidentally, quadratic interpolation may be used in place of linear interpolation. In other words, while linear interpolation is performed by using different gradient coefficients for each of the three zones in the compensation based on the focal length and temperature, if interpolation is made by using a quadratic equation, more accurate compensation for the fluctuation of the lens back may be performed. TABLE 2 ______________________________________ Amount of lens drive (at room temperature) for all-plastic lens 1 2 3 Object j (tele) (middle) (wide) i Distance (m) SP f 58.2˜51.8 51.8˜45.5 45.5˜39.1 ______________________________________ 1 ∞˜1.677 83˜129 Pij 31 30 30 Qij 18 19 16 2 1.642˜0.830 36˜82 Pij 34 33 33 Qij 6 5 3 3 0.821˜0.598 0˜35 Pij 36 35 34 Qij 0 0 0 ______________________________________ TABLE 3 ______________________________________ Correction based on focal length and temperature 1 2 3 T T0 j (tele) (middle) (wide) e (°C.) (°C.) f 58.2˜51.8 51.8˜45.5 45.5˜39.1 ______________________________________ 1 -10˜10 10 Xej 15 16 19 Yej 9 10 12 2 11˜29 10 Xej 14 16 18 Yej 9 10 11 3 30˜50 10 Xej 14 17 19 Yej 8 11 13 ______________________________________ TABLE 4 ______________________________________ Correction based on object distance and temperature Object o 1 2 3 i Distance (m) SP Temp. (°C.) -10˜10 9˜29 30˜50 ______________________________________ 1 ∞˜1.677 83˜129 Zie 0 0 0 2 1.642˜0.830 36˜82 Zie 1 0 -1 3 0.821˜0.598 0˜35 Zie 3 0 -2 ______________________________________ The calculation of reference lens drive amount Kf is explained below. Normally, due to variation experienced in the lens and lens barrel manufacturing and assembly processes, the image point is not positioned properly. To correct this situation an adjustment must therefore be performed during the final assembly process of the camera. There are two methods to correct this discrepancy: one is a mechanical method in which the correction is made by shifting the position of the lens barrel, and the other is an electrical method in which the correction is made by inputting a corrective amount of lens drive to the EEPROM. For photo- taking lenses in which the lens back fluctuates due to changes in temperature, as in the case of the photo-taking lens in which the present application may be applied, it is necessary to change the degree of compensation for the fluctuation of lens back with regard to the temperature in this adjustment process as well. The method of compensating for the fluctuation of the lens back electrically using a jig, as shown in FIG. 13, is explained here. This drawing shows the flow of signals between microcomputer 10, temperature sensor SE or zoom encoder ZE of the camera shown in FIG. 9 and the jig microcomputer (not shown in the drawings). First, performance of lens back adjustment is instructed by sending a lens back adjustment command signal from the jig microcomputer to camera microcomputer 10. Then, by sending a set focal length signal from the jig microcomputer to camera microcomputer 10, it is instructed which of the telephoto, middle and wide zones is to be used. Camera microcomputer 10 moves the lens in accordance with focal length f thus instructed. The temperature of the photo-taking lens is then measured by temperature sensor SE (FIG. 9) placed in the camera and the measurement data is sent to the jig microcomputer. The jig microcomputer stores the temperature data TS output from temperature sensor SE of the camera. When camera microcomputer 10 moves the focusing lens (first lens unit Gr1) in the direction of the infinity position from the initial closest object position, zoom encoder ZE of the camera sends a PI signal to the jig microcomputer for every 1 PI as the focusing lens is moved. The jig microcomputer looks for the MTF (modulation transfer function) peak point while counting the PI signals. The MTF peak point (which has spatial frequency of approximately 20) is the image point position with the highest contrast, and the film is normally located at this peak point. While the initial reset takes place on the side of the camera, the jig microcomputer calculates the Kf value in a manner described below after storing the number of PIs when the MTF peak occurs. When the Kf value obtained through the calculation is stored in the camera EEPROM, the Kf setting operation is complete. The calculation of reference lens drive amount Kf for correction of the image point position necessitated by a change in temperature is explained below. The focal length is divided into different zones, and the Kf value is calculated using the following equations (4) through (8). In this disclosure, equations used when the focal length is divided into five zones (telephoto, telephoto to middle, middle, middle to telephoto, telephoto) are shown. The number of zones is increased from three to five here because while zooming is a relative amount indicated by the amount of shift from a reference position, Kf is a value to determine the absolute amount of shift for the lens to reach the reference position, which requires higher precision. The Kf value for the telephoto zone (Kf(t)) is calculated using equation (4). Kf(t)=PI(t)-Q1j-Y2j-{P1j×SP+X2j×(10-TS(t))}/16 (4) The Kf value for the middle zone (Kf(m)) is calculated using equation (5). Kf(m)=PI(m)-Q1j-Y2j-{P1j×SP+X2j×(10-TS(m))}/16 (5) The Kf value for the wide zone (Kf(w)) is calculated using equation (6) . Kf(w)=PI(w)-Q1j-Y2j-{P1j×SP+X2j×(10-TS(w))}/16 (6) The Kf value for the zone between telephoto and middle (Kf(tm)) to be calculated via interpolation is calculated using equation (7). Kf(tm)={Kf(t)+Kf(m)}/2 (7) The Kf value for the zone between middle and wide (Kf(mw)) to be calculated via interpolation is calculated using equation (8). Kf(mw)={Kf(m)+Kf(w)}/2 (8) In said equations (4) through (8), PI(t) represents the number of PIs for lens drive in the telephoto condition (f=58.2 mm); PI(m) represents the number of PIs for lens drive in the middle focal length condition (f=48.3 mm); PI(w) represents the number of PIs for lens drive in the wide condition (f=39.1 mm); TS(t) represents the measured temperature in the telephoto condition; TS(m) represents the measured temperature in the middle focal length condition; and TS(w) represents the measured temperature in the wide condition. Adjustment and measurement during the final assembly process for the camera normally take place in an air-conditioned room. Where the fluctuation of lens back due to temperature change is marked, the final assembly process should occur in a constant-temperature room in which the temperature is controlled more strictly (an environment in which a certain room temperature is maintained). However, If the correction value Kf to be input is calculated using the temperature of the photo- taking lens measured by temperature sensor SE (the measured temperature data from the sensor) on the side of the camera (the sensor is not limited to one located in lens barrel TB and may be located in camera body BD) as described above, such a constant-temperature room becomes unnecessary, making adjustment of the focus position (namely, lens back adjustment in which the lens drive reference amount is determined) with high accuracy possible under any environment.
Richard melville hall, known by his stage name moby, is an international award winning musician, dj, and photographer he was born in new york city, but grew up in connecticut, where he started making music when he was 9 years old. - caribbean culture and the way it formed one of the greatest debates that exists today about the caribbean is the condition of the socio-culture of the people sidney mintz, antonio benitz-rojo, and michelle cliff are three authors that comment on this problem in their writings. Globalisation and cultural identity in caribbean society: the jamaican case by is the process of synthesis continuing, or is the caribbean culture being subsumed by that of its more powerful neighbour is fluidity an essential aspect of the arguing that identity is a point from which one interprets the world from there, a discussion of. The culture of the caribbean meet intriguing people, unique in character and culture, when you visit the caribbean guadeloupe remains a french possession there are some african influences here, but french customs, culture, and language prevail a passion for song and dance is just one part of taíno culture, while sports and even. The relationship between language and culture is deeply rooted language is used to maintain and convey culture and cultural ties different ideas stem from differing language use within one’s culture and the whole intertwining of these relationships start at one’s birth. There is an intrinsically critical and political dimension to the project of cultural studies which distinguishes it from objectivist and apolitical academic approaches to the study of culture and society. One is the general idea of a cultural blending, of more than one cultural tradition becoming transformed under local conditions to something unlike its antecedents—a process of change with early documentation in the caribbean, and which even began on the slave ships themselves. By adam cash “everybody is unique” is the mantra of the modern era many people pride themselves on being different and one of a kind — particularly in western popular culture and media — and anybody spending any time studying and working with people will tell you there is a great deal of truth to this. Latin american culture is the formal or informal expression of the people of latin america and includes both high culture (literature and high art) and popular culture (music, folk art, and dance) as well as religion and other customary practices. Do you know your real pirates of the caribbean here you will find a list of the most famous pirates from the so-called golden age of piracy real-life pirates of the caribbean culture club / getty images and the fact that he had not one, but two female pirates serving on board his ship: anne bonny and mary read he was captured. The statement, “there is no single caribbean culture” is at once true and incorrect at the same time it is immediately obvious that no two caribbean islands bear the same value systems, norms etc according to the particular historical context. There is no one distinctive caribbean culture, but rather, caribbean cultures each island or geo-political territory, is characterised by its own unique, cultural practices, institutions and belief systems. Caribbean food, news, people, and culture “there is no passion to be found playing small, in settling for a life that is less than the one you are capable of living ~ (nelson mandela. Is there such a thing as a caribbean identity or spirit or culture, shared by all the territories clustered around the caribbean sea, regardless of language or political status yes, is the answer that many of the region’s artists and thinkers and visionaries have given and continue to give. Personality: margaret mead arguably, margaret mead was one of the leading anthropologists of the 20 th century being a student of boas, mead extended the school's knowledge in culture and personality as she focused from the american culture to the whole western world. Culture is not something that an individual alone can possess culture in sociological sense is shared for example, customs, traditions, beliefs, ideas, values, morale etc are all shared by people of a group or society. Figure 31 graffiti’s mix of colourful drawings, words, and symbols is a vibrant expression of culture—or, depending on one’s viewpoint, a disturbing expression of the creator’s lack of respect for a community’s shared space. Ethnic groups tend to be isolated from one another because the mountains are difficult to cross the climate on the caribbean coast of central america is rainier than the climate on the pacific coast because the caribbean coast. Diversitiesin order to define caribbean culture one must bear in mind the population make upeach territory and its culture within the region there are some cultural differences in mostinstances a particular culture which is indigenous to an island/country diffuses to othercaribbean countries. Also, in most caribbean countries, because of a common culture and heritage, ethnic divisions are not significant the exceptions are trinidad and tobago and guyana, where ethnicity has played a major role. Culture culture is similar to ethnicity, yet really more of a microcosm of it it may involve one trait or characteristic, sort of like a subset of the various traits that make up an ethnicity perhaps a person may be ethnically jewish, or they could subject themselves to simply one or two things of jewish culture, such as wearing a kippah this person may not necessarily relate with the. Caribbean culture is at the heart of the caribbean experience while many tourists arrive in the caribbean in search of the perfect paradise many leave with an appreciation for everything that the caribbean truly has to offer - other than its unparalleled landscape. Knowing our history and culture helps us construct our identity and build a sense of pride around being part of the roma nation it gives us an opportunity to speak in one language and to have one vision about our future. One of the principal concerns about the new globalization of culture that is supposedly taking place is that it not only leads to a homogenization of world culture, but also that it largely represents the americanization of world cultures. One author of this paper, who is from the caribbean, was selected as a preferred adviser by many undergraduate african american advisees, because they felt, as one of them, she would know and understand their experiences. However, acculturation does not necessarily result in new, alien culture traits completely replacing old indigenous ones there often is a syncretism , or an amalgamation of traditional and introduced traits. For example, not one culture, in any region of the world, should be given credit for the invention of writing and human civilization, one of your complaints i suspect. Paying attention to customs and cultural differences can give someone outside that culture a better chance of assimilation or acceptance ignoring these can get an unsuspecting person into trouble there are cultural and ideological differences and it is good to have an understanding about a culture's customs and ways. Caribbean identity and culture defining identity but distinctions blur the further one goes from the caribbean is there any support for the view that a µcaribbean identity¶ is more evident among caribbean nationals living abroad than it is among nationals within the region. The caribbean essay - the caribbean perhaps nowhere on earth is a more culturally varying region than in the caribbean the recent history has formed these islands into a confused, random area, hiding much of its people’s identity and heritage. 2018.
http://botermpapervipf.alisher.info/there-is-not-one-caribbean-culture.html
The invention provides an unfolding and folding rudder torque loading test system and method and a medium, and relates to the technical field of mechanism design, the method comprises a folding rudder fixing base, a first flexible adapter ring, a second flexible adapter ring, a high-elasticity rubber rope, a force measuring system, a load applying mechanism, an adjustable fixing mechanism and a folding rudder; mounting a folding rudder fixing base, and suspending the folding rudder; one end of the first flexible adapter ring is connected with the high-elasticity rubber rope, and the other end of the first flexible adapter ring is connected with the folding rudder; the other end of the high-elasticity rubber rope is connected with a force measuring system through a second flexible adapter ring, and the other end of the force measuring system is connected with a load applying mechanism; and the other end of the load applying mechanism is connected to the adjustable fixing mechanism. According to the invention, the aerodynamic load of the folding rudder can be changed along with the unfolding angle, the position and the load are coordinated, and finally, the load application of the folding rudder surface in the millisecond folding rudder dynamic unfolding process is simply and conveniently realized.
Faith took an airplane to visit her grandparents. It was her first flight - and she was sort of nervous about it, especially when she saw how big the airplane was! She flew in a 747, a plane that carries more than 400 passengers, and has wings that stretch nearly 200 feet from tip to tip! How in the world was that huge machine going to get into the air? And once it became airborne, how was it going to stay up there?The answer has a lot to do with the laws of physics - rules that govern the forces that make the natural world work the way it does. Four forces work on objects in flight: lift, thrust, drag and weight. Lift does just what you'd expect: It lifts an object upward. Lift happens when air pressure on the underside of an airplane's wing is greater than the air pressure on top of the wing. An airplane's wings are designed to be curved on top and flat on the bottom - like birds' wings. Each wing has one rounded edge and one flat edge. The rounded edges face forward. The shape of the wings creates unequal air pressure - greater on the bottom, less on the top. The result: The plane lifts up into the air. Here's how that happens: As an airplane flies, the wings split the air that streams over them. The airstreams flow over the wings, to meet up again on the other side. The air flowing across the top of the wing has to go a little further to get to the meeting place. So it travels faster than the air moving across the bottom. The faster air on top of the wing exerts less pressure than the slower-moving air underneath the wing. Greater air pressure pushes the wing up, creating lift. There's an interesting name for this phenomenon. It's called Bernoulli's principle and is a law of physics. The principle - which is named after scientist Daniel Bernoulli, who figured it out about 200 years ago - states that the pressure exerted by air decreases as airflow speeds up. Thrust is the force that propels an airplane forward. The push comes from the energy produced by the airplane's engines. A 747 has four extremely powerful jet engines that can propel it forward at more than 600 miles per hour, for example. Once the engines are roaring, the airplane is pushed forward. It begins to move faster and faster. With the engine creating thrust, the wings create lift, and the plane takes off. Meanwhile, drag and weight work in opposition to lift and thrust. As an airplane plane moves forward, drag works to slow it down. This happens because the air pushes against the surfaces of the plane, resisting forward motion. In order for the plane to keep moving, its thrust must be greater than the drag created by the air it's moving through. The streamlined shape of an airplane's slanted nose and curving wings helps reduce drag. An airplane's weight also tends to draw it back toward the ground. Gravity, the natural force that holds objects on Earth, pulls the weight of the plane toward the ground, as thrust and lift work to hold it up. People who operate airplanes are careful to monitor how much weight gets loaded on a plane. If the plane gets too heavy, its engines may not be able to provide enough thrust, nor its wings enough lift, to keep it steady in the air. The science of moving an object through the air is called aerodynamics. You can experience aerodynamics by riding in an airplane. As you take off, you feel the thrust provided by the engines pushing you back into your seat. Once the plane is airborne, and the forces of lift, thrust, drag and weight are in balance, you'll probably have a pretty smooth ride. If you don't have a chance to ride in a plane as Faith did, you can watch birds in flight to observe aerodynamics. Birds get thrust by flapping their wings. Most birds are very lightweight creatures, with hollow bones, so it doesn't take a lot of thrust to get them into the air. Their wings are perfectly designed to create lift. And they have aerodynamic bodies - pointed beaks, curving wings and feet that they can pull in close to their bodies to reduce drag. We humans aren't so aerodynamic. We could flap our arms forever and never get off the ground. So we travel in airplanes instead. -TIPS FOR PARENTS: Your kids can find out about aerodynamics in action by building and flying paper planes. When they fly paper planes, they provide the thrust by throwing the plane forward. The aerodynamics of the design your child chooses will determine how fast and far the plane flies. The book "Super Flyers" by Neil Francis, an airplane pilot (Addison-Wesley; $6.95), contains blueprints for many different kinds of paper planes, as well as three kinds of kites that can be made at home from plastic bags, paper sacks and typing paper. Or your budding aerodynamic engineers can design their own. -Do you wonder about your body, your feelings, or how things work in the world around you? Send your questions to Catherine O'Neill, HOW & WHY, Universal Press Syndicate, 4900 Main St., Kansas City, Mo., 64112.
https://www.deseret.com/1990/6/6/18865201/how-why-forces-that-enable-objects-to-fly
Apple has pushed out a massive patch to address nearly 60 vulnerabilities affecting Mac OS X. The most serious of the flaws can be exploited by a remote attacker to take over a vulnerable system. Most of the vulnerabilities impact Snow Leopard, the latest version of Apple’s operating system. The batch of fixes addresses more than three times as many vulnerabilities as the update in August, which fixed 18 issues. Among the most serious of the bugs is a memory corruption issue in DirectoryService that may allow a remote attacker to trigger an application crash or execute arbitrary code. According to Apple, the issue only affects systems configured as DirectoryService servers. Apple’s CoreGraphics component has multiple integer overflows tied to its handling of PDF files that can result in a heap buffer overflow. Opening a malicious PDF file can lead to application termination or arbitrary code execution, Apple warned, and the patch fixes the situation by improving bounds checking. Also fixed is an issue involving Apple’s Adaptive Firewall. In certain circumstances, the firewall may not detect SSH login attempts using invalid user names, Apple states in an advisory. The patch resolves the issue by improving detection of invalid SSH login attempts. Apple also removed support for X.509 certificates with MD2 hashes for any use other than as trusted root certificates, stating that they may expose users to spoofing and “information disclosure as attacks improve.” “There are known cryptographic weaknesses in the MD2 hash algorithm,” the advisory states. “Further research could allow the creation of X.509 certificates with attacker controlled values that are trusted by the system. This could expose X.509 based protocols to spoofing, man in the middle attacks, and information disclosure.” Several of the fixes address security issues in QuickTime and open-source components such as Apache, OpenLDAP and OpenSSH. According to Apple, there’s an implementation issue in OpenLDAP’s handling of SSL certificates that have NUL characters in the Common Name field.
https://www.eweek.com/security/apple-issues-massive-mac-security-update/
Editor’s note: We are delighted to present a series by Neil Thomas, Reader Emeritus at the University of Durham, “Why Words Matter: Sense and Nonsense in Science.” This is the fourth article in the series. Find the full series so far here. Professor Thomas’s recent book is Taking Leave of Darwin: A Longtime Agnostic Discovers the Case for Design (Discovery Institute Press). Words are cheap and, in science as in other contexts, they can be used to cover up and camouflage a multitude of areas of ignorance. In this series so far, I have dealt summarily with several such terms, since I anticipated that they are already familiar to readers, and as I did not wish to belabor my fundamental point. “Just Words” I would, however, like to discuss in somewhat more detail a term which is well enough known but whose manifold implications may not even now, it appears to me, have been appreciated to their full extent. This is the historically recent neologism “abiogenesis” — meaning spontaneous generation of life from a combination of unknown chemical substances held to provide a quasi-magical bridge from chemistry to biology. This term, when subjected to strict logical parsing, I will argue, undermines the very notion of what is commonly understood by Darwinian evolution since it represents a purely notional, imaginary term which might also (in my judgment) be usefully relegated to the category of “just words.” The greatest problem for the acceptance of Darwinism as a self-standing and logically coherent theory is the unsolved mystery of the absolute origin of life on earth, a subject which Charles Darwin tried to bat away as, if not a total irrelevance, then as something beyond his competence to pronounce on. Even today Darwinian supporters will downplay the subject of the origins of life as a matter extraneous to the subject of natural selection. It is not. It is absolutely foundational to the integrity of natural selection as a conceptually satisfactory theory, and evolutionary science cannot logically even approach the starting blocks of its conjectures without cracking this unsolved problem, as the late 19th-century German scientist Ludwig Buechner pointed out.1 Chicago 1953: Miller and Urey Darwin famously put forward in a letter the speculation of life having been spontaneously generated in a small warm pool, but did he not follow up on the hunch experimentally. This challenge was left to Stanley Miller and Harold Urey, two much later intellectual legatees in the middle of the 20th century who, in defiance of previous expert opinion, staged an unusual experiment. The remote hinterland of this experiment was as follows. In the 17th century, medical pioneer Sir William Harvey and Italian scientist Francesco Redi both proved the untenability of spontaneous generation: only life can produce life, a finding later to be upheld by French scientist Louis Pasteur in the latter half of the 19th century; but the two Americans proceeded on regardless. Far-Reaching Theological Implications There is no getting away from the fact that the three-fold confirmation of the impossibility of spontaneous generation by respected scientists working independently of each other in different centuries brought with it far-reaching theological implications. For if natural processes could not account for life’s origins, then the only alternative would be a superior force standing outside and above nature but with the power to initiate nature’s processes. The three distinguished scientists were in effect and by implication ruling out any theory for the origin of life bar that of supranatural creation. So it was hardly surprising that there emerged in later time a reaction against their “triple lock” on the issue. In what was shaping up to become the largely post-Christian 20th century in Europe, the untenability of the abiogenesis postulate was resisted by many in the scientific world on purely ideological grounds. The accelerating secularizing trends of the early 20th century meant that the outdated and disproven notion of spontaneous generation was nevertheless kept alive on a form of intellectual life-support despite the abundant evidence pointing to its unviability. For presently both the Russian biologist Alexander Oparin and the British scientist John Haldane stepped forward to revive the idea in the 1920s. The formal experiment to investigate the possibility of spontaneous generation had then to wait a few decades more before the bespoke procedure to test its viability in laboratory conditions was announced by the distinguished team of Miller and Urey of the University of Chicago in 1953. Clearly the unspoken hope behind this now (in)famous experiment was the possibility that Pasteur, Harvey, and Redi might have been wrong to impose their “triple lock” and that mid 20th-century advances might discover a solution where predecessors had failed. If ever there was an attempt to impose a social/ideological construction of reality on science in line with materialist thinking, this was it. Next, “Imagining ‘Abiogenesis’: Crick, Watson, and Franklin.” Notes - For the reception of Darwin in Germany, see Alfred Kelly, The Descent of Darwin: The Popularization of Darwin in Germany, 1860-1914 (Chapel Hill: North Carolina UP, 1981).
https://evolutionnews.org/2022/04/considering-abiogenesis-an-imaginary-term-in-science/
Novel targets for neuroprotection in neonatal brain injury Developing brain is highly susceptible to injury. Together, prematurity and hypoxic ischemic encephalopathy (HIE) account for 50% of global mortality and significant neurodevelopmental impairment in survivors. HIE is a clinically defined syndrome of disturbed neurologic function due to a lack of oxygen and diminished perfusion to the brain around the time of birth, in the absence of other causative factors. HIE injury occurs in three phases over days to weeks (Fig. 1). Understanding the injurious and protective factors involved in each phase allows for development of potential neuroprotective therapies. HIE occurs in 1.5 to 4 per 1,000 births in developed countries, and in as many as 26 per 1,000 live births in resource-limited settings. Without treatment, two thirds of affected infants die within the newborn period, or develop permanent neuropsychological handicaps, including intellectual disability, cerebral palsy, epilepsy, sensorineural hearing loss or vision loss. Therapeutic hypothermia (TH) is the current standard of care in high income countries. Multiple randomized clinical trials have shown that TH significantly reduces the combined outcome of death or severe neurodevelopmental impairment from 65% to 40-50%. While the benefits of TH provide proof of concept that outcomes can be improved, additional treatments to further improve outcomes are needed. Many promising pharmacological agents for neonatal neuroprotection are either in preclinical research or clinical trials (Fig. 2). Clinical Trials of New Therapies Erythropoietin (Epo) is a hormone required for red blood cell production and brain development. It acts by binding to cell surface Epo receptors, and in animal studies, reduces inflammation, cell death and has regenerative effects in brain. Epo is now in phase III clinical trials as prophylaxis for preterm brain injury, and as a neuroprotective treatment for term infants with HIE undergoing TH. Other potential neuroprotective agents in clinical trials include melatonin, Xenon, and allopurinol. Stem cell therapy has shown neuroprotection and improvement in functional outcomes in animal models of neonatal brain injury, but the optimal cell type and dose is still under investigation. Umbilical cord blood (UCB) is enriched with mesenchymal stem cells and is autologous to the patient making this appealing. Phase I and II studies have shown UCB to be safe. Pharmacological Treatments in the preclinical stage of development N-Acetyl-L-cysteine (NAC) is a potent antioxidant, and precursor of glutathione. It reduces inflammation and improves cell survival. Polyphenols are molecules present in fruits and herbs with anti-inflammatory, cell survival and regenerative properties. Curcumin is found in Turmeric (Indian spice), and Resveratrol in grapes and wine. Both have been shown to be neuroprotective in animal models of HIE. Nanomedicine has emerged as an important field for delivering drugs to specific targets. Nanoparticles, such as polymeric dendrimers, can bind drugs, target their uptake by specific cell types, and modulate drug delivery. This can increase bioavailability of drugs and decrease dose-dependent side effects. Ideal neuroprotective treatments should be safe, readily available, inexpensive and effective when given after an injury occurs. Many strong candidates like Epo, melatonin and stem cell therapies are in clinical trials to evaluate their efficacy in neonatal brain injury. Pratik Parikh, Sandra Juul Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, USA Publication Neuroprotective Strategies in Neonatal Brain Injury. Parikh P, Juul SE J Pediatr. 2018 Jan Leave a Reply You must be logged in to post a comment.
https://atlasofscience.org/novel-targets-for-neuroprotection-in-neonatal-brain-injury/
Research shows that creating an environment that is safe, respectful and inclusive for everyone makes for higher levels of creativity, innovation, productivity and overall competitiveness, whether that be in the context of a country, city, company or team. Yet recent studies also reveal that a high percentage of LGBTQ+ employees consistently report facing discrimination, harassment, bullying, and isolation in workplaces globally. People and culture are a core element of our company’s operating model, the ABB Way. ABB has a deep-rooted commitment to diversity and inclusion which is central to the company’s 2030 sustainability strategy and its focus on social progress. As such, ABB prohibits discrimination on the basis of any dimension, including gender identity, ethnicity, sexual orientation, culture, religion, ability, age, etc. In September 2020, Maria Varsellona, ABB’s General Counsel and Company Secretary, was named as the executive sponsor for LGBTQ+ inclusion within ABB. Her appointment was a significant step forward to highlight LGBTQ+ inclusion as a management priority within the company and as an essential dimension in its diversity and inclusion strategy. “I am proud to serve as the Executive Committee sponsor for LGBTQ+ inclusion,” says Varsellona. “The past year has been a time of momentum-gathering and capacity-building within ABB on this topic. We’ve made real strides in terms of all three pillars of our diversity and inclusion strategy with respect to LGBTQ+, including governance and policy, inclusive leadership and culture, and partnerships. I am so pleased to see this issue championed at every level of the company and in geographies around the world.” In 2020, as part of ABB’s commitment to the LGTBQ+ topic, Varsellona signed on behalf of ABB the Standards of Conduct for Business Tackling Discrimination against Lesbian, Gay, Bisexual, Trans and Intersex People, put forth by the Office of the United Nations High Commissioner for Human Rights. The Standards of Conduct provides five concrete steps that companies can take to align their policies and practices with international standards on human rights of LGBTI people. ABB expects these standards to be followed by its suppliers to generate a real impact in the 100+ countries the company operates in. Becoming an official signatory to these standards publicly underscored ABB’s commitment to this issue, a commitment that was further codified in an explicit amendment to the company’s Code of Conduct. Additionally, partnerships with Stonewall (a UK-based non-profit dedicated to working with institutions on LGBTQ+ inclusion) and Open for Business (a coalition of leading global companies dedicated to LGBT+ inclusion) have been established. In pursuit of more inclusive leadership and culture, ABB has instituted mandatory training on how to interrupt unconscious bias for all leaders on a worldwide basis. As part of the company’s Open Job Market an inclusive approach to job descriptions for external postings has been introduced. Also, “Count on us!” campaigns have been initiated to support LGBTQ+ employees in coming out. In recent months, LGBTQ+ Employee Resource Groups (ERGs) have been launched in Europe, the United States, Latin America and Poland. ERGs are voluntary, employee-led groups that connect based on shared characteristics and experiences to foster a diverse, inclusive workplace aligned with ABB’s purpose and business priorities. Collectively, LGBTQ+ ERGs across ABB now boast more than 400 members, creating a critical mass of committed people working to support education, foster empathy and drive engagement on this theme.
https://new.abb.com/news/detail/79219/pride-month-inclusion-means-everyone?_ga=2.99825054.1057671635.1624926074-143459329.1594366466
The vision of the mind is a issue that includes questions around the nature within the mind and the ways in which often the mental and also the physical usually are related. An individual prominent concept is that of dualism, which feels that the body-mind are 2 distinct places. The most important dualist theorist one’s time was Rene Descartes. His or her famous offer, ‘I think, therefore I am, ‘ intended that mainly because he could end up pregnent of his / her being, he was a being. He or she concluded that the exact mental and also physical are actually distinct for a couple reasons: i’m sure of the particular mental (we know most people think), although we can’t be as absolutely sure about the actual; one is not able to divide mental performance, but the first is able to break down the body; last of all, because one could imagine oneself living without having a body, your head and the shape must be individual entities. Such dualist strategies that Descartes’ proliferated have been, and still usually are, very powerful, but they are greatly rejected too. One critical figure who may have rejected Descartes’ dualist thoughts is Antonio Damasio. Damasio presented a disagreement that feeling and cause are hooked up and not different. He told me the body may be the origin for thought, but not vice-versa. One cannot obtain acceptance within your body as a result of thought, because of the body is the origin of idea. To Damasio, dualism had been flawed for the reason that body happens before head, and therefore they must not be different (Chalmers, 2002: 2). The following essay will serve to illustrate what Descartes’ error has been, according to Damasio; what were definitely its ramifications regarding medication; what alternate Damasio available; whether his particular criticisms appear to be valid; and also whether Damsio’s alternative principle is persuading. From this it will be clear the fact that Descartes may err in the theory in the event dualism. Damasio’s principle conflicted by using dualism, the reality is he was quite concerned with the very implications the fact that dualist philosophy might have, notably on the way the very scientific drugs was approached. Descartes’ served taking issues associated with biology out from the mind, all this was a terrible thing, grow older must keep pace with understand the thought process in scientific terms, or maybe in terms of the approach it interacts with the body system.fast food argumentative essay In fact , if we resolve to grasp the mind devoid of taking into consideration neurological factors, it is cause for burglar alarm (Damasio, 247). Within deconstructing Descartes, Damasio conceded the important role he had for crafting the learning of viewpoint of the mind, and the incontrovertible fact that he was particularly deconstructing it is just a tribute towards his deliver the results. His issue over Descartes’ work ended up being that he segregated the mind and the body; where Damasio contemplated them to link. According to Damasio, Descartes’ make a mistake was the approach he had assured biologists discover the body without having relating that to the thought process. In doing therefore , biologists regarded the body much like they do your clock, to be a series of interconnected mechanical techniques that can be tinkered with and glued. To Descartes, the body was the machine as well as mind did wonders separately, when the ‘thinking thing’ (Damasio, 248). While already featured, the essence belonging to the difference regarding the two theorists was which will comes first, the bodies cells or the thought process. If we think about a baby who might be just brought into the world, their valuable physical becoming comes well before their thought, which ensures that their idea is a item of their appearing. This was Damasio’s view, where Descartes’ seemed to divinity to legitimize his belief that the brain comes well before body, plus the mind persuaded itself the fact that the body it all perceives is normally real (Damasio, 248). Descartes’ built many preuve in his documents that are considered even more very unlikely to go along with. For example , he asserted that heat is actually moved our own blood. Still Damasio was not concerned with these ideas which have been uncovered and accepted as fake. He is involved with those suggestions that Descartes’ espoused which will still maintain influence, basically the idea that ‘I think, i really am’ (Damasio, 250). He was concerned with typically the implications seek out have about the medical savoir. In fact , the idea that a disembodied mind is available has shaped the blocks of American medicine, all this was bothering to Damasio. It is therefore because it opened the way to ignore the effects of which ailments with the body experienced on the thoughts, and also the effects that conditions of the intellect have figure. These, depending on Damasio was important tasks of medicine, all of us were neglecting them by reason of our incorrect interpretation on the mind-body way. The malfunction in Descartes’ work appeared to be that he protected the origins of the real human mind, this also led contemporary society to context it in a very completely unacceptable way (Damasio, 251). It is obvious what Damasio thought, that was that an idea of the mind ‘requires an organismic perspective; this not only need to the mind shift from a nonphysical cogitum on the realm regarding biological flesh, but it should also be in connection with a whole structure possessed regarding integrated physique proper in addition to brain as well as fully fascinating with a natural and social environment’ (Damasio, 252). Damasio offered an alternative approach, though. He or she did not would like to give away virtually all aspects of as their pharmicudical counterpart to a range of thinking that stopped working everything into its most organically grown form. He or she wanted to adhere to the originality and impressiveness of every plaintiff’s mind the actual it performs. To do this, have to acknowledge towards ourselves how the mind is really a complex, fragile, finite, and also unique apparatus, and can be thought of with principles of energy not chemistry and biology. This preserves the dignity of the notion of the mind which can or may not have already been Descartes’ wider intention.
https://redphaseindia.com/the-connection-amongst-mind-and-body/
Partners in Culturally Appropriate Care (PICAC) NSW & ACT is pleased to announce the launch of the PICAC, My Aged Care CALD Accessibility Project, funded by the Australian Government Department of Health. This two year project will specifically identify and target the barriers that culturally and linguistically diverse (CALD) older people experience when accessing the My Aged Care Gateway. The My Aged Care CALD Accessibility Project will assist the Department of Health to develop strategies that will support both established and emerging CALD communities in navigating the aged care system. “The successful uptake of The My Aged Care Reforms for people from culturally and linguistically diverse groups will only be realised if they are underpinned by the concepts of cultural and linguistic responsiveness, inclusiveness and sensitivity. It is vitally important that this project identifies the current barriers which are faced by the elderly CALD communities of Australia. The project will develop recommendations which will lead to a sustained building of the capacity and knowledge about aged care services for our elderly CALD consumers Australia-wide.” Cecilia Milani, PICAC NSW & ACT Manager The project will involve working collaboratively with various organisations and stakeholders in high CALD demographic areas. This will be conducted through a series of national surveys, CALD community focus groups and consultations. A key promotional initiative for the project will be PICAC NSW & ACT’s upcoming CALDWays 2016 forum, scheduled to take place in Canberra in mid-June. If you would like to provide feedback about the My Aged Care Gateway or register your interest to attend or speak at CALDWays 2016, please contact:
https://www.mac.org.au/identifying-my-aged-care-barriers-for-cald-older-people/
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to . To save content items to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service. You can save your searches here and later view and run them again in "My saved searches". This study examines the effects of input quality on early phonological acquisition by investigating whether interadult variation in specific phonetic properties in the input is reflected in the production of their children. We analysed the English coda stop release patterns in the spontaneous speech of fourteen mothers and compared them with the spontaneous production of their preschool children. The analysis revealed a very strong positive input–production relationship; mothers who released coda stops to a lesser degree also had children who tended to not release their stops, and the same was true for mothers who released their stops to a higher degree. The findings suggest that young children are sensitive to acoustic properties that are subphonemic, and these properties are also reflected in their production, showing the importance of considering input quality when investigating child production. Young children simplify word initial consonant clusters by omitting or substituting one (or both) of the elements. Vocalic insertion, coalescence and metathesis are said to be used more seldom (McLeod, van Doorn & Reed, 2001). Data from Norwegian children, however, have shown vocalic insertion to be more frequently used (Simonsen, 1990; Simonsen, Garmann & Kristoffersen, 2019). To investigate the extent to which children use this strategy to differing degrees depending on the ambient language, we analysed word initial cluster production acoustically in nine Norwegian and nine English speaking children aged 2;6–6 years, and eight adults, four from each language. The results showed that Norwegian-speaking children produce significantly more instances of vocalic insertions than English-speaking children do. The same pattern is found in Norwegian- versus English-speaking adults. We argue that this cross-linguistic difference is an example of the influence of prosodic-phonetic biases in language-specific developmental paths in the acquisition of speech. This study examines the development of speech rhythm in second language (L2) learners of typologically different first languages (L1s) at different levels of proficiency. An empirical investigation of durational variation in L2 English productions by L1 Mandarin learners and L1 German learners compared to native control values in English and the learners’ L1s showed that the L1 groups followed comparable developmental paths in their acquisition of vocalic variability and accentual lengthening. However, the two L1 groups diverged in the proportion of vocalic materials in their L2 utterances, exhibiting L2 acquisition patterns that are consistent with direct transfer from the L1. The results support a multisystemic model of L2 rhythm acquisition in which the various linguistic-systemic properties that contribute to speech rhythm are acquired at different proficiency levels and depend on different acquisition processes with respect to L1 influence and universal effects. We conclude that theories of L2 phonology need to be able to accommodate the multisystemic nature of L2 prosodic acquisition. Additionally, L2 phonological acquisition theories, and SLA theories more generally, should take into account the nonuniform manner in which the various prosodic properties of the interlanguage reflect L1 transfer effects as well as universal constraints on acquisition. Email your librarian or administrator to recommend adding this to your organisation's collection.
https://core-cms.prod.aop.cambridge.org/core/search?filters%5BauthorTerms%5D=Brechtje%20POST&eventCode=SE-AU
The hotel’s 182 rooms, all 45 m2 Junior Suites, are divided into three types: - 113 double Junior Suites with views of the sea and the dunes. Third, fourth and fifth floors. - 39 double Junior Suites with views of the gardens. Second floor. - 30 double Junior Suites with terrace, on the first floor. The rooms have been specially designed to ensure our guests enjoy a peaceful break, including attention to every detail: Essential facilities - Soundproofing guaranteed - Quality sleep: 2×1 metre beds with 30 cm top quality mattresses to guarantee your comfort.Broadband WiFi in rooms. - Safe. - 49” inch flat-screen TV positioned for viewing both from the lounge and the beds, with more than 25 international channels. - Fully equipped bathroom: Two-basin vanity unit, Honeycomb bathrobes, Magnifying mirror, 1800 Watt hairdryer, Top range amenities. - Daily cleaning service.
https://www.santamonicasuiteshotel.com/en/rooms/
True to its name, the SandRose Guesthouse offers a peaceful and quiet haven for the business traveler or person looking for a quiet breakaway in Windhoek. SandRose strives to give all its guests a sense of comfort while trying to preserve an African theme in all of its rooms. We are situated a five-minute walk from Kubata Lodge which offers one of the best Portuguese restaurants, and Joe's Beer House if you want to experience true Namibian cuisine. We are only a 10-minute walk from the city centre. For those on business trips, SandRose provides an environment that is equipped with the necessary facilities to help you stay in contact with the world - from telephone lines to 24-hour Internet connection. We also provide facilities to keep guests entertained at all times. There is a beautiful swimming pool for those hot and sunny Namibian days, and a pool table among other things.
https://www.myguidenamibia.com/accommodation/sandrose-guesthouse
Museum Technicians & Conservators Description : Restore, maintain, or prepare objects in museum collections for storage, research, or exhibit. May work with specimens such as fossils, skeletal parts, or botanicals; or artifacts, textiles, or art. May identify and record objects or install and arrange them in exhibits. Includes book or document conservators. JobTitles : Conservator, Objects Conservator, Paintings Conservator, Conservation Technician, Exhibit Technician, Paper Conservator, Collections Manager, Preparator, Museum Registrar, Art Preparator Tasks: - Clean objects, such as paper, textiles, wood, metal, glass, rock, pottery, and furniture, using cleansers, solvents, soap solutions, and polishes. - Determine whether objects need repair and choose the safest and most effective method of repair. - Install, arrange, assemble, and prepare artifacts for exhibition, ensuring the artifacts' safety, reporting their status and condition, and identifying and correcting any problems with the set-up. - Direct and supervise curatorial, technical, and student staff in the handling, mounting, care, and storage of art objects. - Perform tests and examinations to establish storage and conservation requirements, policies, and procedures. - Prepare artifacts for storage and shipping. - Photograph objects for documentation. - Coordinate exhibit installations, assisting with design, constructing displays, dioramas, display cases, and models, and ensuring the availability of necessary materials. - Notify superior when restoration of artifacts requires outside experts. - Lead tours and teach educational courses to students and the general public.
https://www.careerfittest.com/app/getdescription/25-4013.00-Museum-Technicians-and-Conservators
Elias & Co. Staffing is seeking a hard chrome plater. Responsibilities • Must be able to read traveler to determine the optimum process for the designated part to be plated and follow the traveler process specifications step by step. • Will sets up and control plating equipment to coat metal objects chemically with chromium to provide protective surfaces. • Will monitor process control of all plating and cleaning baths to ensure process is within predetermined parameters. • Must be able to follow established safety procedures and work instructions. • Measures, marks and masks areas exclude from plating per traveler. • Must be able to operates overhead crane for submerging the parts in plating or cleaning baths. • May operate electroplating equipment with reverse polarity, known as platting stripper. • Will work with substances defined as hazardous waste, such as chrome sludge. • Could potentially handle hazardous waste in containerizing, transporting, testing, or other assigned duties. • Responsibilities will include production line plating, chemical waste handling, plating of Hexavalent chrome on steel and metal parts. • Other related tasks include but are not limited to acid etching, antiquing, powder coating and other related tasks. Requirements • Must have hazardous waste water experience or plating line operations. We do not plate raw plastic or raw zinc. • Must be able to read blue prints • Experience with Microsoft Office Skill such as Excel, Work and Outlook • Must have excellent math skills; this position will require you to be able to calculate square inches of parts to be chromed • Knowledge of plating process and able to operate rectifiers • Position requires accurate use of a tape measure. • Must be able to lift up to 70 lbs and use lifting devices • Work history must be current • Must be able to perform your duties without any limitations or restrictions. • You will be asked very specific job-related questions prior to be offered a position. • Must have at least 3 years of active production line experience.
https://jobboard.tempworks.com/EliasHR/Jobs/Details/18379?Keywords=None&Distance=Fifty&SortBy=Relevance&RowNum=13
Try FatSecret Mini Home Foods Food List Tea with Milk Other common serving sizes 1 fl oz 100 g 100 ml 1 teacup (6 fl oz) 1 mug (8 fl oz) Calories 23 Fat 1.11 g Carbs 2.01 g Protein 1.26 g There are 23 calories in 1 mug of Tea with Milk. Nutrition Facts Serving Size 1 mug (8 fl oz) Amount Per Serving Calories 23 % Daily Values* Total Fat 1.11g 1% Saturated Fat 0.637g 3% Trans Fat - Polyunsaturated Fat 0.066g Monounsaturated Fat 0.277g Cholesterol 3mg 1% Sodium 19mg 1% Total Carbohydrate 2.01g 1% Dietary Fiber 0.1g 0% Sugars 1.84g Protein 1.26g Vitamin D 0mcg 0% Calcium 44mg 3% Iron 0.03mg 0% Potassium 97mg 2% Vitamin A 9mcg 1% Vitamin C 0mg 0% * The % Daily Value (DV) tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice. Last updated 11 May 20 07:41 PM Source FatSecret Platform API Calorie Counter 100% Free Other common serving sizes Serving Size Calories 1 fl oz 3 100 g 10 100 ml 10 1 teacup (6 fl oz) 17 1 mug (8 fl oz) 23 Related types of Tea Herbal Tea Tea (Brewed) Lipton Black Tea Bags Tea Presweetened with Sugar Tea Unsweetened Green Tea More Tea Nutritional Info Related types of Beverages Coffee Cola Soda (with Caffeine) Orange Juice Milk Lemonade Water More Beverages Nutritional Info More Related Foods Lipton Milk Tea Dunkin' Donuts English Breakfast Tea with Milk Dunkin' Donuts Earl Grey Tea with Milk Sangaria Royal Milk Tea Argo Tea Earl Grey Vanilla Creme with 2% Milk (Medium) View More Results Contains these Ingredients 34 g Milk (whole) 202 g Water 0.8 g Tea (instant powder, unsweetened) Please note that some foods may not be suitable for some people and you are urged to seek the advice of a physician before beginning any weight loss effort or diet regimen. Although the information provided on this site is presented in good faith and believed to be correct, FatSecret makes no representations or warranties as to its completeness or accuracy and all information, including nutritional values, is used by you at your own risk. All trademarks, copyright and other forms of intellectual property are property of their respective owners. FatSecret Sites For Everyone FatSecret For Developers FatSecret Platform API FatSecret Brand Tools For Professionals FatSecret Professional mobile.fatsecret.com Foods Recipes Food List Brand List Terms Privacy Contact Us Blog Full Site United States © 2020 FatSecret. All rights reserved.
https://mobile.fatsecret.com/calories-nutrition/generic/tea-made-from-powdered-instant-and-milk?portionid=2423181&portionamount=1.000
The increasingly interdisciplinary nature of contemporary scientific research requires that biologists, chemists, computer scientists, mathematicians, physicists, and psychologists have a fundamental understanding of one another’s areas. For this reason, the educational mission of New York University Abu Dhabi emphasizes the integration of the life, physical, mathematical, and computer sciences with other academic disciplines. This integration manifests itself in the multidisciplinary nature of research at New York University Abu Dhabi, research that addresses some of the most pressing issues affecting the globe while simultaneously asking questions that further the basic understanding of nature and the universe. The prudent fusion of science, math, and other academic disciplines at New York University Abu Dhabi has resulted in the creation of state-of-the-art research centers and core technology platforms in which questions and problems are tackled in projects led by scientists of international distinction. Climate change and its consequences; drug discovery; human behavior, learning and the mind; understanding the universe and its constituents; environmental sustainability; synthetic biology; and genomic approaches to systems biology are among the pivotal areas currently studied at New York University Abu Dhabi. In many cases, the cultural and natural environments of the United Arab Emirates provide unique opportunities that are heightened further by the campus’s place within New York University’s network of sites that spans the globe, especially including the prolific scholarship found at its schools and colleges in New York City. The Division of Science at New York University Abu Dhabi offers undergraduate majors in biology, chemistry, computer science, mathematics, physics, and psychology, with areas of specialization in some. Graduate degrees are offered in biology, chemistry, computer science, and physics. Postdoctoral training opportunities are also available. In all cases, multidisciplinary research is encouraged along with attendance at the profuse number of seminars, colloquia, and symposia held at New York University Abu Dhabi to produce future leaders in science who also embody global awareness, cultural sensitivity, and ethical integrity.
https://nyuad.nyu.edu/en/academics/divisions/science/about.html
Several peptides of diverse structure, reported to possess high affinity and selectivity for the δ opioid receptor, were studied using the mouse isolated vas deferens preparation to determine the effect of peptidase inhibition on their apparent potency. The peptides evaluated included [Leu5]enkephalin, the cyclic enkephalin analogs [D-Pen2, D-Pen5] enkephalin (DPDPE) and [D-Pen2, p-F-Phe4, D-Pen5]enkephalin (F-DPDPE), the linear enkephalin analogs [D-Ala2, D-Leu5]enkephalin (DADLE) and [D-Ser2(O-tBu), Leu5, Thr6]enkephalin (DSTBULET), and the naturally occurring amphibian peptides Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 (dermenkephalin), Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2 (deltorphin I) and Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 (deltorphin II). Concentration-response curves were determined for each peptide in the absence and presence of a combination of the peptidase-inhibiting agents bacitracin, bestatin, and captopril. A wide range of potencies was observed, both in the control state and in the presence of peptidase inhibition. The synthetic enkephalin analogs demonstrated small increases in potency with peptidase inhibition (no increase in the case of DPDPE), whereas the naturally occurring peptides were markedly increased in potency, up to as much as 123-fold for dermenkephalin. In the presence of peptidase inhibition, deltorphin II was the most potent peptide tested (IC50 = 1.13 X 10-10 molar), and as such is the most potent delta opioid agonist reported to date. Stability to metabolism must be considered in the design and evaluation of in vitro experiments using peptides of this type.
https://experts.arizona.edu/en/publications/influence-of-peptidase-inhibitors-on-the-apparent-agonist-potency
Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease. A series of novel Diallyl disulfide (DADS) derivatives were designed, synthesized and evaluated as chemical agents, which target and modulate multiple facets of Alzheimer's disease (AD). The results showed that the target compounds 5a-l and 7e-m exhibited significant anti-Aβ aggregation activity, considerable acetylcholinesterase (AChE) inhibition, high selectivity towards AChE over butyrylcholinesterase (BuChE), potential antioxidant and metal chelating activities. Specifically, compounds 7k and 7l exhibited highest potency towards self-induced Aβ aggregation (74% and 71.4%, 25 μM) and metal chelating ability. Furthermore, compounds 7k and 7l disaggregated Aβ fibrils generated by Cu(2+)-induced Aβ aggregation by 80.9% and 78.5%, later confirmed by transmission electron microscope (TEM) analysis. Besides, 7k and 7l had the strongest AChE inhibitory activity with IC50 values of 0.056 μM and 0.121 μM, respectively. Furthermore, molecular modelling studies showed that these compounds were capable of binding simultaneously to catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. All the target compounds displayed moderate to excellent antioxidant activity with ORAC-FL values in the range 0.546-5.86Trolox equivalents. In addition, absorption, distribution, metabolism and excretion (ADME) profile and toxicity prediction (TOPKAT) of best compounds 7k and 7l revealed that they have drug like properties and possess very low toxic effects. Collectively, the results strongly support our assertion that these compounds could provide good templates for developing new multifunctional agents for AD treatment.
Get the Facts on Irritable Bowel Syndrome For those with Irritable Bowel Syndrome, everyday life is complicated by stomach pain and irregular stools. Here’s why – and how to find relief. By Camille Platt None of us like to talk about the time we spend in the bathroom. But knowing if your bowel habits are abnormal is important for both overall health and quality of life. For more than 1 in 10 adults, bouts of abdominal pain, gas, constipation, and diarrhea interfere with daily life. April is Irritable Bowel Syndrome (IBS) Awareness Month, and it’s time to lift the veil on a long-term condition many find hard to admit. What is IBS? One of the most common conditions seen by doctors, IBS is a gastrointestinal tract disorder involving the colon and small intestine. It is considered a “functional disorder” because symptoms occur absent of any visible abnormality – the colon and bowel tissue appear normal upon examination by a physician. And yet, the nerves and muscles in the gut have become over-sensitive. While symptoms often change over time, the key to an IBS diagnosis is reoccurring pain or discomfort in the abdomen coupled with a change in bowel habits. You may experience bloating and excessive gas as well as loose stools (diarrhea), difficulty passing stools (constipation), or an alternating cycle of the two. How is it diagnosed? If several symptoms persist over time, and are often relieved by a bowel movement, you could be suffering from IBS. IBS issues may fluctuate over time, or resolve only to return later in a different variation. This can make for changes in your treatment plan change over time. “IBS is a chronic condition with no cure, so it’s critical to establish a therapeutic physician-patient relationship based on trust,” says Dr. Vijay Patel, a gastroenterologist with Galen Digestive Health Associates. Often, a physician will begin by ruling out other conditions or diseases, says Dr. George Samuel, a gastroenterologist with East Tennessee Gastroenterology and Tennova Healthcare – Cleveland. “I start by asking, ‘Could this patient have a more serious condition like cancer or bowel disease?’ and looking for red flags like nausea, vomiting, bleeding, or weight loss,” he says. “Once I’ve ruled those out, I can focus on symptomatic treatment.” What causes IBS? It’s not known exactly what causes irritable bowel syndrome, but a variety of factors play a role. The gastrointestinal tract is lined with muscles that move food toward the rectum in a series of contractions. If the contractions last too long or are too severe, your IBS will flare up with gas, bloating, and diarrhea. If the contractions are too weak, your food will pass too slowly, leading to constipation. The key to managing the syndrome is discovering what exacerbates it. While IBS is not caused by lifestyle choices, flare-ups can worsen with specific triggers. Read on to learn more. How does my diet affect IBS? “Oversensitivity to certain foods is often thought to be one culprit of IBS,” says Dr. David Castrilli, an internal medicine physician with CHI Memorial Internal Medicine Associates. “Initial treatment often focuses on identifying problem foods through trial and error and eliminating them from the diet.” Alcohol, fatty foods, chocolate, broccoli, fruit, carbonated drinks, and caffeine can irritate an already-sensitive gastrointestinal system. Eating large portions can also stimulate the bowels and lead to nausea and cramping. “As a general rule, IBS patients should avoid gas-producing foods, and in certain cases, lactose and gluten,” says Dr. Patel. “IBS can also be triggered by alcohol, caffeine, insoluble fiber intake, and certain carbohydrates.” “Here in the U.S., we are subject to a diet high in sugar, carbs, and processed foods, and this has significant ramifications for both our digestive health and overall health status,” says Dr. Samuel. “Personally, I feel correcting your diet is a non-negligible component of IBS treatment, and it should be presented as a primary way to relieve symptoms. By working with IBS patients to change how they eat and drink, I can see improvement in 60 to 70% of cases.” How do stress and anxiety affect my IBS? We all know the pressure of a new job, a big test, or a strained relationship can lead to belly issues. For those with IBS, it intensifies existing symptoms even more. “IBS patients suffer from an increased gastrointestinal response to stress, so in many cases addressing stress is the mainstay of treatment,” says Dr. Patel. Some physicians will prescribe a low dose antidepressant – both for mood and to help lower the pain signals sent from the gut to the brain. Tricyclic antidepressants like Norpramin can be effective in relieving abdominal pain and reducing diarrhea. Selective serotonin reuptake inhibitors (SSRIs) have been shown to help with IBS-related anxiety and constipation. “As we assess a patient’s situation, determining which came first – stress or IBS – can feel like chicken or the egg,” says Dr. Samuel. “Often, as I’m asking questions to unravel what’s happening in a patient’s life, they will begin to cry and I will begin to see the bigger picture: that stress is a major component and should become a primary focus.” Can a low FODMAP diet help? > > > > > > > > It can, depending on the type and severity of your symptoms. Developed by an Australian research team, the low FODMAP diet is based on the way the body digests carbohydrates. “FODMAPs are short chain carbohydrates that are poorly absorbed and rapidly fermented in the intestines,” says Dr. Patel. “Consumed in excess, they can result in bloating and pain.” These tiny carbs can be found in certain fruits, vegetables, grains, and foods made with high fructose corn syrup or high lactose. They should be eaten in moderation—not eliminated—with the help of a trained dietician. After six to eight weeks, you can review your progress and begin to reintroduce certain foods. However, a low FODMAP diet can be tricky to manage with accuracy. “While I strongly recommend this type of diet to patients before starting a medication, it can be difficult to avoid these foods and sugars here in America, even for people who are very health conscious,” says Dr. Castrilli. “In the typical American diet, sugars are hidden everywhere. It can make it difficult to identify the causative food.” If you want symptom relief, but aren’t ready to jump into a FODMAP diet, you can start by avoiding gluten, lactose, alcohol, caffeine, certain sugars, and gas-producing foods like beans, onions, celery, carrots, raisins, bananas, apricots, prunes, and Brussels sprouts. You can also look to increase your intake of soluble fiber. Can probiotics help? If you suffer from gastrointestinal issues, you may have heard that probiotics, which are live bacteria and yeasts found in yogurts and other fermented foods with active live cultures, can bring relief. But do they work? According to Drs. Patel and Castrilli, it’s possible probiotics could help with digestion, particular for those with diarrhea. However, little scientific evidence exists to establish it as an effective treatment for IBS. Bottom line? If you feel they help you, they can’t hurt. But doctors usually focus on other treatments. “This is a popular question right now since so many products are being advertised for intestinal health,” says Dr. Castrilli. “Probiotics have been studied to some extent, but no clear evidence has established them as an effective treatment for IBS. I don’t usually encourage patients to take them. But I see no harm if a patient would like include them in their diet.” Can medication help? If you suffer a flare up, your doctor may recommend a supplement or prescribe a medication to treat your primary symptom. For example, if you have IBS with constipation (IBS-C), your doctor may recommend taking an over-the-counter soluble fiber supplement like psyllium (Metamucil) or methylcellulose (Citrucel) with fluids. If this doesn’t work, he or she may recommend polyethylene glycol (GlycoLax, MiraLax) or prescription lubiprostone (Amitiza) or linaclotide (Linzess). Likewise, if you have IBS with diarrhea (IBS-D), your doctor may recommend taking an anti-diarrheal like loperamide (Imodium) before leaving home or eating a meal. If you need a stronger option, he or she may recommend prescription cholestyramine (Questran, Prevalite) or other medications that bind to bile acids. However, it’s essential to understand that the majority of IBS patients will see improvement after making diet and lifestyle changes and managing stress.
https://healthscopemag.com/health-scope/what-is-your-gut-telling-you/
Working with Ben Thomas on this project was an absolute delight. We have dreams to turn my PhD thesis into an 'ethno-graphic' novel - anyone want to fund it? (Serious question). Ben's creativity has brought to life elements of my research in ways I could not. Have you ever wondered what it’s like to work with an illustrator when seeking to disseminate research results? Well, I asked Ben some questions to get his insights on what it is like to work with an academic, including how we approached what I call 'retrospective (re)presentation': using the visual to offer alternative modes of (re)presentation to the written ethnographic text. Check out our chat below. Ben, tell us about your journey into illustration.. I guess like most people, I started drawing at a very early age; unlike most people, I didn’t stop. I never really had any formal art education, other than an A-level course in art. Illustration has always been my hobby - making characters, dreaming up worlds. I only really started doing it professionally (and part-time) a few years ago, doing the odd job here and there for friends and acquaintances, fitting it in when I can on days off and late nights after work. How did you feel working as an illustrator on the project? This project hasn’t been without its challenges. Fitting in a project like this on top of my full-time day job has been tough at times, but despite this I would say that working on this project has been a real privilege. Charlie’s research highlights an issue that we usually hear very little of in the West, and bringing the stories of these people and their struggles to life as an illustrator has been both challenging and eye-opening. I’ve learned a lot and I’m excited to have been able to help bring Charlie’s research to a wider audience. From a practical point of view, it’s also been a lot of fun to draw people and settings that I might not in most of my other illustrations, and push myself and my art further and grow as an artist. How did you choose to order the panels? As I mainly do illustration, I don’t have a lot of experience when it comes to making comic strips. But I think the most important thing when it comes to making comics, more than art style or even art quality, is storytelling. Does the strip tell the story that we want it to? Is it easy for the audience to read it and follow that story? Does that story flow from one panel to the next? For example, there was a panel from an earlier draft of one of the comics that didn’t make it into the next draft. Both Charlie and I really liked the panel and thought about including it again, but despite it being a nice panel to look at, it didn’t really fit into the story we were telling. These are the kind of things I had in mind when drawing the comics. I hope I succeeded! How much of your own style did you bring to the images? I think whenever I draw anything, whether I’m conscious of it or not, it’s impossible for me to do it without having something of my own style in there somewhere. For this particular project, quite a lot of what I would call my style is included, from colour and drawing tool choices, to the way the characters look and feel. Recently I’ve been obsessed with using watercolour-style brushes and textures in my digital art (I’m hopeless at using actual watercolour paints!) and, with the theme of water at the forefront of much of Charlie’s work, I thought it was a perfect choice. What do you think illustrations / comics can bring to academic representations of statelessness / children's lives? As a non-academic, I can probably speak for most of my fellow non-academics when I say I haven’t read a whole lot of academic research lately! Having research presented in a medium like comics or illustration can make that research - and the social, cultural or scientific issues that it addresses - accessible to a much wider audience. However ‘good’ or ‘important’ it is, I’m much more likely to read someone’s PhD thesis if it’s presented to me in a fun, beautiful (and shorter!) format. I think perhaps comics and illustration can also help to bring that research to life on a more emotional, personal level. Academic research can, out of necessity, feel distanced from the people and issues that it represents, and by focusing on the stories of individuals, storytelling through the arts can help bridge that gap between the academic and the real lives and emotions of the people involved. What was it like to have your drawings directed / judged by an academic? Working with Charlie has always been a pleasure. I think we both bring different things to the table, and having someone with a much deeper understanding of the research and its cultural context was certainly helpful in trying to make the illustrations as authentic as possible. In that regard, Charlie would always offer helpful criticism or suggestions for things to add to the scene, whereas I could perhaps offer more in terms of making our images tell the story we wanted to. So the illustrations and comics were very much a collaborative effort. Here's a gallery of Ben's work on the project. Enjoy.
https://www.charlierumsby.com/post/illustratinganthropology
This course is aimed to improve the students’ ability to translate managerial questions into economical and financial terms through the acquisition of a set of tools and reasoning skills. Decision-making is central to managerial activity. Decisions cover a wide range of topics, including launching products, pricing, make-or-buy decisions, dropping a product or an activity, just to name a few. Managers make their decisions based on a mix of financial, economic and strategic analyses. One of the primary roles of management accounting is to provide useful and structured information for these decisions, assessing the profitability of alternatives. Apply management accounting techniques to usual managerial situations. Full Cost methods (two step allocation method, Activity-Based Costing and Activity-Based Management) and their application to products’ and customers’ profitability analysis.
https://www.hec.edu/en/master-s-programs/master-management/course-content/m1-general-management-phase/methods-cost-analysis
Whether important or trivial, we are faced with making numerous decisions daily, a daunting task. Mastering this skill is nothing short of an art form! If you struggle with making decisions, they you may need to consider what your style is (Yes, that’s a thing!) Intuitive: This style is more prevalent among the spontaneous types and as the definition suggests, it tends to be rather immediate and depends largely on experience or a penchant for risk taking. Limited procrastination: This involves delaying decision-making until one has enough information or until enough factors have been evaluated and enough time has gone by for a situation to stabilise. This style should however not be confused with avoidance or not wanting to make a decision. Systematic: Identifying and evaluating each possible course of action is key in this decision-making style. Have in mind, that in many instances, it is close to impossible to have all the facts, this should not stop you though. An informed decision is the best information. Individualistic: This involves researching and arriving at a decision without any external input. By consensus: This applies to decisions that have to, or should preferably, be arrived at as a group. Identify the decision to be made together with the goals it should achieve. Note that as you arrive at your decision, consider the scope and limitations involved in the decision. Try as much as possible to develop alternatives and weigh the pros and cons. Tom Robbins, an American author once said, “Stay committed to your decisions, Everyone has oceans to fly, if they have the heart to do it. Is it reckless? Maybe. But what do dreams know of boundaries? Not all decisions are permanent. Do not hesitate to change direction if a particular decision is evidently not working out or is detrimental. Nailing how to make timely, well-considered decisions, can make the difference between stagnation in life or well-deserved success.
https://parentsafrica.com/important-lessons-on-decision-making/
By Caroline Tapp-McDougall While stairs can be barriers and hazardous, moving into a bungalow or limiting access to one floor of your home may not be an option. If you find yourself with stair climbing challenges, you’ll probably want to look into installing some sort of stairlift or elevator. When looking for a stairlift, you may find yourself confused by technical jargon and the wide range of models available. You should be able to get informed advice from an occupational therapist or other home-care pro in your area. Read on for some basic info about what’s available and what you should consider when buying a lift. Wise advice—be cautious when considering pre-owned equipment, as many safety features have changed in newer models. Here are three basic stairlift types: 1) Conventional stairlifts This is the most common type of lift, generally used by people who can walk but have trouble with stairs. Fixed to a straight or curved track, these lifts can usually be mounted on either side of the staircase. While most lifts come with a chair, there are models for people who prefer to stand or perch on lift. Here are two options to think about: • Folding armrests and footplates: Many lifts block off quite a bit of the stair area, so you may need to fold away footplates, armrests, and the seat while the lift is not being used. If you’re going to need to fold the footplates, make sure that this can be done safely and easily, because it may need to be done several times each day, and it can be a very tricky task! • Swivel seats: When getting off the lift, the person using it needs to turn themselves around so that they’re facing away from the stairs. A swivel seat can make this much easier. Check for models that can be operated either manually or electrically depending on your needs. • Wheelchair access: Think about: How will the person get their wheelchair on and off of the lift? Is there enough room at the top and bottom of the stairs to get the wheelchair on the lift? Will you need two wheelchairs? One at the top and one at the bottom? Make sure there is enough room on the lift for the person, their wheelchair, and a helper if necessary. 2) Wheelchair platform lifts These lifts, specially designed to handle wheelchairs, are often the most practical option for someone who needs to get up and down the stairs without leaving their wheelchair. If you’re considering this option, note that you may need to lower the area at the bottom of the stairs to provide level access for the wheelchair over the platform. Also, make sure there’s enough space at the top and the bottom of the stairs for the wheelchair to turn around when the person’s getting off. Think about how other people may be inconvenienced by the lift. 3) Vertical or through-floor lifts Check out this option if there’s not enough room around the stairs for a regular lift or a wheelchair platform lift. This lift will carry the person from a place like the living room on the lower floor up to a bedroom or landing. The lift car can be either fully or partially enclosed, and the lift can be constructed with or without a shaft, depending on your needs. Do note that this option can be quite expensive, since renovations are often required! In most cases families are able to adjust quickly and easily to stairlift additions, but it’s vital that safety functions that lock or stop the lift in emergencies are working to protect in case of falls, pets, or young children. • Think about space: Stairlifts run on tracks and generally take up quite a bit of room on the stairs. Be sure to ask sales representatives how much room the lift will take up on the stairs and whether any parts can be folded away easily to make room. • Safety first: Stairlifts will stop if they encounter any object or person obstructing the stairs. Through-floor lifts and wheelchair platform lifts also have mechanisms to prevent someone being crushed by them. Lifts also generally have guards to prevent fingers from moving parts. Caroline Tapp-McDougall is a healthcare journalist and author of The Complete Guide For Family Caregivers. Stairlift purchasing tips Seek advice: Ask an occupational therapist to advise you on the best choice of lift for your home. When purchasing, be sure to ask as many questions as you need to about the lifts, since installing a lift can have a significant impact on your home configuration and lifestyle. Try before you buy: Purchasing and installing a lift can be a significant investment. Be sure to try out any model before buying to make sure that it suits your needs. Ask for a home demonstration: A sales representative may be able to arrange a visit for you to someone’s home so that you can see first-hand what a stairlift or through-floor lift is like. Take this opportunity, if you have it! Consider funding options: Lifts and structural adaptations are expensive. Think about funding options before you decide to make a purchase. Some benefits or insurance packages cover home modifications and lifts, but often only if labour costs and equipment purchases are pre-approved.
https://www.caregiversolutions.ca/caregiving/wise-advice/the-joy-of-stairlifts/
Department of Human Genetics The Department of Human Genetics performs groundbreaking research into the relationship between genes and diseases, notably concerning blindness and deafness, cancer, congenital anomalies, and mental handicaps. To identify and functionally characterize novel disease genes, we utilize a combination of biochemistry, genomics technologies, molecular biology, cell biology, and developmental systems such as Drosophila melanogaster, zebrafish and mouse. These studies will also uncover therapeutic strategies. We have created a friendly, stimulating interdisciplinary research environment hosting groups that lead their fields. If you would like to visit or join our research group, we encourage you to contact us. Department of Cognitive Neuroscience The Cognitive Neuroscience departement participates in the Donders Centre of Neuroscience of the UMC St Radboud and the Radboud University Nijmegen. The Centre of Neuroscience is part of the Donders Institute for Brain Cognition and Behaviour, together with the Centre for Cognition and the Centre for Cognitive Neuroimaging. There is a close collaboration with the Nijmegen Centre for Molecular Life Sciences (NCMLS). Department of Psychiatry The main research topic of the Department of Psychiatry can be summarized as: research of (mal)adaptive processes of cognitive and emotional control in behavior, which are the basis of psychiatric disorders. Subthemes are for instance: Adaption and consolidation, and reaction patterns. This topic also focuses on genetic and environmental determinants of differences between individuals and their appraisal of, and reaction to stimuli.
http://cognomics.nl/runmc.html
January 20, 2017 we will present the 14th Guelph Lecture – On Being Canadian The Guelph Lecture—On Being Canadian continues to broaden the scope and number of voices that promote and foster public dialogue on, and greater understanding of, ideas and issues of concern to Canadians. The Eramosa Institute, presenting the Guelph Lecture in partnership with Musagetes, the Literary Review of Canada, and the University of Guelph, offers a new, multi-day event called the Spur Festival Guelph. Over three days, the festival offers lectures, conversations, musical performances, literary readings, film screenings, and city walks that will consider how we imagine new possibilities for the world beyond the status quo. The 2017 Guelph Lecture—On Being Canadian, will serve as the centrepiece of the three-day Spur Festival. We are very excited to once again be part of Spur Guelph as we bring together a cast of imaginative thinkers and performers who will engage audience members with an array of ideas, not just for Canadians, but for everyone. See below to get a taste of what we presented at our last event in November 2015. Tickets will be available online at riverrun.ca, by phone at 519-763-300, and in person at the River Run Box Office. Purchase By PhoneBox Office: 519-763-3000 By PhoneBox Office: 519-763-3000 Purchase In PersonRiver Run Box Office River Run Box Office 35 Woolwich St, Guelph, ON N1H 3V1, Canada Monday to Saturday 11 am to 6 pm Reviews “The ability to adapt is what helps to define us as Canadians…innovation, creativity, and fresh, new thinking.” “An absolute world class slate of individuals to push forward our thinking as they share their views about being Canadian” Franco Vaccarino University of Guelph, President “An annual event that does so much to generate the necessary conversation about how we live in a time of great difficulty and a time of great possibility” Robert Enright,
http://thegl.org/
Find out which training program is right for your organisation. Subscribe to the CPI Insights Newsletter You will receive emails with industry news and perspectives from CPI. One Kind Wordis the theme of Anti-Bullying Week (w/c November 15th) across England and Wales this year. Now, more than ever, following 12 months of lockdown and isolation we need to be kind and compassionate to each other. This year’s theme is centred around hope and the positive and kind things we can do to put an end to bullying behaviour. But what can we do as educators to proactively reduce the incidents of bullying in our schools across the country and create an environment where everyone feels safe and secure? There’s no doubt if there are incidents of bullying in schools then they need to be dealt with quickly and effectively. However, creating a strong school culture, built on positive relationships where all young people feel valued, and part of a community, can promote prosocial behaviour and reduce the incidents of bullying. Fostering a culture of kindness, of positive relationships will not only enhance connections on every level but it will help nurture empathy and understanding between one another. School connection is an important protective factor for many of our learners. If a young person has a strong sense of belonging to their school, their classroom, their community, then they will be less likely to try and sabotage the positive culture that has been created. Kindness is contagious. The best way to spread it is to be kind yourself. It’s the adult who sets the weather in the classroom; adults who are consistently calm, use kind words, are polite, respectful and patient have pupils who emulate them. Make everyone feel welcome and valued. Every day is a fresh start, regardless of the behaviour you may have witnessed from some of your learners the day before. Deal with the behaviour and then move on. Deliberately go out of your way to build emotional currency with all your learners. Connect on some level with every young person in your care and do what you can to make them feel part of your school community. It’s these little acts of kindness that can help break down barriers and start to build trusting relationships. You may think that you are only teaching history or mathematics, but you are also constantly teaching behaviour. Your young people are learning how to be compassionate, how to be empathetic, how to react in stressful situations just by watching your behaviour, and how you react in certain situations across the course of a school day. We need to be considering how we are upholding the value of kindness in our interactions; when dealing with our colleagues, speaking with parents, connecting with our learners or when intervening with inappropriate behaviour. When we drop this value apologise, show humility, demonstrate that mistakes are part of life and we all make them. But what’s important, is how we learn from our mistakes and how we repair, restore and move forward. What kind of behaviour are we focussing on first? Who are the most famous learners in our classrooms and schools? If the answer is ‘those who are always displaying the most inappropriate behaviour’ then something needs to change. If we really do get more of the behaviour we notice the most, then let’s flip the culture. Let’s turn our first attention to those learners who are always displaying the ‘over and above’ behaviours. Let’s catch all our learners doing the right thing and praise, recognise and appreciate their effort. Make your learners believe that you believe in them. Change the narrative; in your classroom it will be the best behaviour that gets your first attention, your enthusiasm and passion. You will publicly praise in abundance when it is earned and when behaviour slips, you will intervene in a consistent, calm manner as privately and as you can. Sometimes, our emotional reactions to behaviour incidents can instantly sabotage the relationships we work so hard to establish. Planning our responses, what we are going to say and do, can help us keep our emotions in check and respond in a more rational, kind manner, keeping your and your learner’s dignity intact. Not only do we want to develop an ethos in our schools and in our classrooms that enables us to build and maintain relationships, but we also want to create an environment where we repair harm when things break down. Punitive systems in schools can often create resentment rather than reflection. We want our learners to behave well because it is the right thing to do. We want them to be take responsibility for their behaviour, develop empathy and consider the impact their behaviour has had on others and reflect on how they can change this in the future. Our role as adults is to set clear boundaries, have high expectations and challenge for every young person in our care. We then need to match that high challenge with high level of support, nurture, empathy, listening and kindness. Most importantly, we need to consistently make clear to our learners that they are unconditionally accepted and valued. Investing our time to build healthy relationships and connections with our learners and families should continue to be our priority. Only when our young people feel like a valued part of their classroom and school they will they begin to accept and take on the culture and values of the school.
https://www.crisisprevention.com/en-ie/Blog/One-Kind-Word-What-we-can-do-to-end-bullying
These kinds of interviews are an excellent idea. I appreciate the way Lin examines, on the one hand, Eliot’s and Puritans peers to use this Bible as part of a broader Christianization process, but then also looking at how two Indian collaborators assisted him in the act of translating. Then the complicated and unpredictable process of reception and appropriation get put into play. This attention to the complex and multilayered ways in which groups and individuals interact and influence each other strikes me as one of the central imperatives of doing good history. I imagine a work of this sort provokes excellent discussion, Lin. - Hi Linford: Great post. I’m curious though, what do you think students most take away from the experience of seeing the bibles first hand? How is that different from what they get when you only have them read the text from the internet? Is there a difference? I know I get excited when I hold in my hands something old and perhaps famous (Roger Williams!). But I wonder how those endorphins shape my interpretation. Any thoughts? - Thanks, Curtis, for your thoughts, and Kevin, for your question. I agree that much of this can be accomplished without seeing the Eliot Bible (or other books) in person. But I’m a big believer in tactile approaches to history—visits, objects, etc., simply because I think it brings an additional dimension of understanding, historical empathy, and observation. Seeing the Eliot Bible in person, students always are surprised at how thick it is. To own a copy as a Native was also a physical identification with European Christianity (or at least potentially) – whether as a point of pride or something that would have incurred derision. I try to get my students to imagine what it must have been like to have held it for the first time as a Native person, and think through the possible layers of meanings it represented: a tangible representation of the religion of the English (after all, the many laws the English imposed were often based on this book, or so Natives were told); a physical emblem of spiritual power (for “salvation” or otherwise); a symbol of the importance of the written word and literacy (imagine the immense frustration of knowing it was written in your language and yet you potentially could not read it); an instrument of colonialism – the imposing of ideologies and ideas; and yet a means of spiritual reflection, engagement, and reshaping for some Natives, as evidenced in the marginalia of some of the Bibles. Again, you can do much of this while using a PowerPoint slide, but to be there in person, to hold the Bible, to page through it, to see marginalia in Native languages (when present), and to imagine the many layers of meaning for Natives in the seventeenth century, I find is often an experience that leaves an impression for students, especially given the electronic world they have grown up in. Or perhaps I am just a hopeless history romantic when it comes to objects! - Fascinating ideas, Lin. I’m not a history prof, but I can recall how thrilling it was to see the Magna Carta and other treasures in London. The Eliot Bible is, in itself “real history”. I was pretty moved by seeing the 1685 version in the Congregational Library.
http://www.teachingushistory.co/2013/01/in-the-beginning-with-linford-fisher.html
View our video from the recent YMCA Cruise DInner! Aaron. Carol, Mike & Alaina Newsletters - Don’t Let Debt Derail Your Retirement This article looks at high debt levels among older Americans and why it’s important to analyze and address debt before retirement. - HOT TOPIC: Rising Rates Join Long List of Housing Dilemmas This article explores how soaring housing costs, rising rates, and declining affordability could impact borrowers and the housing market. - ETFs Are Gaining on Mutual Funds: Here’s Why Are you familiar with the differences between mutual funds and exchange-traded funds? This article compares and contrasts the two. - Four Reasons to Review Your Life Insurance Needs This article looks at major life events and the need to review your life insurance coverage in light of changing circumstances. Calculators - IRA Eligibility Use this calculator to determine whether you qualify for the different types of IRAs. - Roth IRA Conversion This calculator can help you determine whether you should consider converting to a Roth IRA. - Home Affordability Estimate of the maximum amount of financing you can expect to get when you begin house hunting. - Credit Card Debt How Long Will It Take to Pay my Balance?
https://www.mikewoll.com/
Trail Hub is situated on the ecologically significant Oak Ridges Moraine. It is an important part of Ontario’s biodiversity and feeds the headwaters, providing clean drinking water to millions of people living in the GTA. We are committed to a sustainable future and improving the social, economic and environmental well-being of the Township of Uxbridge and the surrounding communities. Accordingly, Trail Hub will: - Make business decisions using the lens of creating the best outcomes for our shared environment; - Continually seek opportunities to improve our environmental performance; - Implement pollution prevention and waste minimization policies to reduce, reuse, and recycle materials; - Ensure that energy and water are used responsibly and work to minimize adverse environmental impacts; and - Provide employees with the knowledge and tools needed to meet these goals of this policy and collaborate with others in the region to prevent negative environmental impacts on the Oak Ridges Moraine.
https://trailhub.ca/index.php/about/environmental-commitment
ONC releases updated recommendations for pediatric health IT Children have specific and unique medical needs – and software supporting their care should be tailored to help address those needs. The Office of the National Coordinator for Health IT has published a new informational resource aimed at shaping the specifications of technology products intended for pediatric use. "There are critical functionalities, data elements, and other requirements that should be present in health IT products to address healthcare needs specific to the care of children," according to ONC. The agency focuses on 10 recommendations that align to "clinical priorities that were identified by the American Academy of Pediatrics in partnership with relevant stakeholders across the country," wrote Senior Policy Advisor Samantha Meklir and Medical Informatics Fellow Al Taylor in a blog post Wednesday. They noted that "significant contributions were also made by healthcare organizations and federal partners to provide detailed review and feedback" on the resource, which describes ONC-developed certification criteria specific to certain pediatric clinical priorities and offers additional technical specs to help developers working with childcare providers. WHY IT MATTERS The recommendations outlined in the informational resource included the use of biometric-specific norms for growth curves and support for growth charts for children; the computation of weight-based drug dosage; the synchronization of immunization histories with registries; and age- and weight-specific single-dose range checking. Other recommendations acknowledged the potential complications and privacy concerns around providing children care, for example: the ability to document all guardians and caregivers; transferrable access authority (as in the case of foster care, adoption, divorce or patient emancipation); and segmenting access to information. "Adolescents may be allowed by law or practice to sequester access to information, such as sexual and behavioral health history in their health record," according to ONC's recommendations. "Some jurisdictions require sequestering a child’s record of sexual history or abuse." "Sequestering patient-selected information from parental, billing, or insurance communications may be required to protect an adolescent or pediatric patient’s privacy," the resource continued. As for the care of newborn patients, the ONC recommends associating maternal health information and demographics – such as infections, immunizations, blood type and heritable genetic conditions – with the infant, given the data's potential importance in follow-up care. It also recommended the ability to track incomplete preventative care opportunities, since doing so is "key to maintaining a pediatric patient's health," and flagging special healthcare needs. "All pediatric practices provide care for individuals or groups of patients whose needs cannot always be accurately captured by using standard code systems," according to ONC. Poor usability, said Ben Moscovitch, Pew's project director of health information technology, can lead to dangerous medical errors, such as a patient receiving the wrong dose of a drug. "Forthcoming regulations from ONC on EHRs used in the care of children and the development of a new reporting program offer opportunities to enhance usability – which would simultaneously reduce burden and improve safety," said Moscovitch. ON THE RECORD "This [resource] may continue to evolve in the future as gaps are filled and more work is done to expand the tools, functionalities, and standards available for use by healthcare providers who care for children," said Meklir and Taylor about the new recommendations. "We look forward to collaborating with clinicians, hospitals, standards developers, health IT developers and others to continue this work." Kat Jercich is senior editor of Healthcare IT News. Twitter: @kjercich Healthcare IT News is a HIMSS Media publication.
Omaeluloolisus eesti teatris: Merle Karusoo lavastustest. Life Narratives and Estonian Theatre: The Productions of Merle Karusoo AbstractAny consideration of Estonian theatre from the point of view of biographical theatre needs to include the work of playwright and director Merle Karusoo. Productions based on various life narratives (diaries, letters, biographical interviews) form the core of her work that can be defined as biographical or memory theatre. Her work has also been viewed within the context of community theatre or political theatre; Karusoo has herself referred to her work as sociological theatre. Life narratives have functioned in Karusoo’s productions as the basis for restoring oppressed or denied collective discourses of memory. Her productions emerged within the framework of the more general process of restoration of historical heritage and the rehabilitation of collective memory at the end of the 1980s and the beginning of the 1990s. Life story can be viewed as the essence of Merle Karusoo’s theatre. The personal in the life story in the production activates the emotional memory of the audience; for older generations such theatre facilitates a legitimisation of remembering one’s life story in entirety, and for younger generations it functions as a vehicle of collective, historical and national memory. The current article outlines the main stages of Karusoo’s biographical theatre, highlights major productions of each stage and provides an overview of their reception. Karusoo’s theatre dates back to 1980s. Productions based on life stories of the generations born in 1950s and 1960s, Meie elulood (Our Biographies) and Kui ruumid on täis ... (Full Rooms) both in 1982, mediated fragments of life stories of 16 drama students, focusing on the processes of self-conception and -reflection of young persons. In the context of the Soviet regime that exerted firm ideological control over the private lives of its citizens, Karusoo’s productions struck an especially powerful and unusual chord. Karusoo’s biographical theatre has gathered momentum and assumed a more solid shape since the end of the 1980s. Productions based on the diaries and/or letters of women--Aruanne (The Report, 1987) and Haigete laste vanemad (The Parents of Sick Children, 1988)--are mono-dramas, reflecting upon the loss of the voice and life story of an individual and the theme of historical conformism and fear brought about by the violent and hypocritical nature of the Soviet society. The next stage of Karusoo’s work focused on the “destiny years” of the Estonian nation, featuring, for example, life stories focusing on failed emigration to the West and the life experience of those executing the orders of the Soviet authorities during the 1949 deportations. Productions such as Kured läinud, kurjad ilmad (Snows of Sorrow), Sügis 1944 (Autumn 1944), both in 1997 and Küüdipoisid (The Waggoners, 1999) belong to this stage. The reception of Waggoners as a production that eroded the “us” and “them” binaries of the national community was especially polemical. In 2000, when the bilingual Save Our Souls was staged, focusing on the lives of prison inmates convicted of manslaughter and featuring both Estonian and Russian-speaking actors, marked the emergence of the theme of ethnic minorities in Estonia in Karusoo’s work. Karusoo’s biographical productions have evolved from generational life stories and the life stories of individuals to collective portraits of historically and/or socially determined groups. In 2006 Karusoo staged generation monologues Täna me ei mängi (Today We Will Not Play) and Küpsuskirjand 2005 (Essay 2005) that make visible how the semantic space of “us” and the phenomenon of “returning” the life stories to the people have assumed increasingly wider dimensions in Karusoo’s work over decades. Karusoo’s theatrical method has been compared with the work of Jerzy Grotowski and Eugenio Barba, Ariane Mnouchkine and Suzanne Osten, Anna Deavere Smith and German theatrical grouping Rimini Protokoll. Karusoo has herself emphasized that the process of self-conceptualisation needs to proceed via the story of one’s own people, and the past has to be remembered in an emotional way. Her biographical theatre has subjected life stories to artistic filtering, resulting in the enhancement of their affective resonance as well as in generalizations. Her productions have theatrically mapped an extensive share of Estonia’s life narrative and historical memory-scapes. Downloads Download data is not yet available.
https://ojs.utlib.ee/index.php/methis/article/view/524
Rimexolone, marketed by Alcon Pharmaceuticals as Vexol, has been available since 1994. It is supplied as a 1% eye drop solution that is applied topically to the eye. It is used primarily to treat swelling in the tissues of the eye. Its use was discontinued in 2008. Since that time, Vexol has been replaced with other similar treatment options such as prednisolone sodium phosphate or diclofenac sodium. Doctors and patients should be aware that there are fraudulent distributors claiming to offer supplies of Vexol, but this medication is no longer being produced at all under that name or in that particular formulation. Any stock of Vexol is either expired or a different formula or medication being sold as Vexol. Rimexolone is not indicated for use of any sort of viral or bacterial infection of the eye as it does not contain any sort of antibiotic ingredient that would address the infection. Rimexolone, or Vexol, does cause some side effects in patients. Typically, those side effects are very mild. Most common is a burning or stinging sensation upon application of the drops or a little blurry vision that corrects itself within a few minutes. However, it can occasionally have serious side effects such as changes in vision or increased risk of infections. Rarely, use of rimexolone has been linked to the onset of other illnesses such as rhinitis or pharyngitis. Prolonged use of this medication can cause the development of com/health/coma/">glaucoma or cataracts. Patients who have already had an issue with cataracts or glaucoma should use this medication only sparingly and under close medical supervision with frequent monitoring for those conditions. In very few cases, rimexolone has been linked to allergic reactions of various degrees from swelling of the eyes where applied to hives and skin rash. An allergic reaction is more likely in patients who have experienced hypersensitivity to other steroid and corticosteroid medications. Rimexolone does interact negatively with a few medications. It should not be used in conjunction with or in proximity to the administration of any smallpox vaccine. It can worsen the gastrointestinal side effects associated with some chemotherapy and anticancer medications, especially those that treat aplastic anemia or renal cancers. Rimexolone generally should not be prescribed concomitantly with other steroid-based medications, as that can be an unsafe combination as well. Overdose is not a really considered a danger with rimexolone. Patients would have really had to deliberately apply too much of the medication to result in any real danger to the eye itself. Chronic and prolonged use represents a far greater risk than an overdose at any given time. Like any medication, rimexolone can cause side effects. These are usually quite mild and would not indicate that the patient needs to stop using this medication. Mild side effects include: Rarely, patients do experience more severe side effects that usually result in the patient going back to the doctor and changing medications. These can include: Some patients may experience an allergic reaction to rimexolone. That sort of reaction requires immediate medical attention and discontinuation of use of medication. Signs of an allergic reaction include: The usual delivery of rimexolone is in the form of a 1% solution. In treatment of swelling of the eye resulting from surgery, the recommended dosage protocol is one to two drops of Vexol (rimexolone) every six hours for a period of 14 days. For treatment of anterior uveitis or injury, the standard protocol for treatment is one to two drops every hour during the waking day for one week. In the second week, the prescription is reduced to one to two drops every two hours during the day. Reduce usage from that point, applying as needed until the condition is resolved. Overdose of rimexolone is not considered dangerous. While rimexolone is a relatively mild medication, it does interact with a few other medications. In terms of a moderate interaction where concomitant use is not contraindicated, the medications would include: All of these medications are ophthalmic medications as well. A medication that interacts negatively and should not be used in conjunction with rimexolone is the smallpox vaccine, either in the brand name form of ACAM2000 or Dryvax. It is also contraindicated for patients taking the cancer medication Aldesleukin. Ceritinib and rimexolone taken in combination can cause an increased risk of hyperglycemia. Patients taking the iron chelator deferasirox for treatment of various anemias should add rimexolone with caution, as it has been shown to exacerbate the digestive issues that sometimes accompany use of deferasirox (i.e. bleeding of the gastrointestinal tract or ulceration of the GI tract). Patients who use rimexolone over an extended period of time are more likely to develop a fungal infection of the cornea. This should be monitored if the patient is using the eye drops for more than one round of treatment. For patients suffering from viral infections of the eye, use of Vexol is contraindicated. Examples of these sorts of infections include conditions such as vaccinia, mycobacterial infection, varicella and epithelial herpes simplex keratitis. Use of Vexol (rimexolone) may extend the length of the infection or exacerbate the symptoms it causes. Use of corticosteroids such as rimexolone can cause thinning of the sclera and/or the cornea. It may also compromise the patient's immune system, making infection more likely. Extended use of Vexol has been linked to the development of glaucoma, cataracts and other forms of damage to the optic nerve. For patients with a history of cataracts or glaucoma, use of rimexolone should be approached cautiously and with medical supervision. It can also cause an increase in intraocular pressure, which may result in damage to the optic nerve or cornea and ultimately damage the vision of the patient. Rimexolone should not be prescribed to patients who have shown hypersensitivity or an allergic response to steroids. One danger of Vexol, particularly in prolonged use, is the masking of infection and other symptoms. It may also damage visual acuity, especially peripheral fields of vision. Vexol ophthalmic solution is for topical use only. It should not be injected. The dropper that comes with the solution should not come in direct contact with the eye or any other surface as that can lead to contamination of the solution. Patients should not use any other solutions or topical eye medications in conjunction with Vexol, unless prescribed by their physician. Patients who wear contact lenses should discuss this with their doctor and whether or not these can be worn while using rimexolone. There has been no indication that use of rimexolone while pregnant represents any danger to the fetus. This is also true for nursing mothers and infants, but patients in either situation should proceed with caution. Patients should share with their physician any other medications they are taking, both prescription and over the counter. This is especially true if they take inhaled nasal steroids on a regular basis. While rimexolone does not interact adversely with many medications, patients respond differently to various combinations of medication. If the patient's condition does not improve within a few days of beginning treatment, the physician should consider alternative therapies. In less than 2% of cases, use of rimexolone has been linked to the onset of chronic headache, pharyngitis, hypotension, dysgeusia, and rhinitis. Rimexolone has not been studied in pediatric patients and is not recommended for use in children. Vexol (rimexolone) is delivered as a 1% solution in a vial with an eye dropper. It should be stored upright and at room temperature. The bottle should remain tightly closed and stored away from direct sunlight and excessive moisture. It should be kept out of the reach of children and pets. This medication is only viable for four weeks after it has been opened. Patients should dispose of medication once they have completed their course of treatment, even if some of the solution remains. Rimexolone, brand name Vexol, is a corticosteroid ophthalmic solution for use in the treatment of certain eye conditions linked to inflammation, swelling and pain in the eye caused by injury, surgery or other non-infectious cause. It is not indicated for treatment of viral or bacterial eye infection. It is also not approved for use with pediatric patients. RImexolone is prescribed as a 1% solution and is a relatively mild medication that has limited interaction with other families and classes of drugs. Its major interactions are with certain anticancer and chemotherapy drugs and with the small pox vaccine. It is also not recommended as a first line of treatment for patients with a history of glaucoma or cataracts as prolonged use of Vexol may cause a recurrence of these conditions. Prescribed dosages are usually one to two drops every couple of hours for seven days with a reduction in application times in the second week of treatment. If the patient's condition has not improved within 14 days of use of Vexol, the prescribing physician should reevaluate and explore other treatment options. Production of Vexol was discontinued in 2008 and is no longer available for prescription or treatment. Other similar medications are available, including flurbiprofen sodium and bromfenac, that have a similar mechanism of action.
https://healthery.com/drug/rimexolone-ophthalmic/
You may have read the email message from the OSA Board with the news that Ms. Staci Smith will be leaving OSA next year. On behalf of the APT Board we would like to express our deepest appreciation and gratitude to Staci for her dedication and commitment to the students and families of OSA. She has done so much during her time at OSA, it's hard to capture it all in this email. Without a doubt, Staci's leadership led the way to our recent charter renewal. The bottom line is, that she led the way when we weren't sure we would make it through. She did so with steadfast unwavering leadership. At times leadership means stepping aside and letting the community lead alongside and with, and that is what she did. That is a sign of a strong leader. Thank you, Staci. This was a complex, stressful and difficult process that she managed with grace, strength, and determination. Staci has been the senior leader of OSA during our current school year, stepping in to stabilize our school during a very difficult time. It was clear during the most challenging moments that Staci kept us moving forward because she believes so strongly in OSA, our history, our future, and the staff and students. This departure is even more difficult because we will not be coming together for the remainder of the year to honor Staci in the way that she truly deserves. In her email today she mentions that she will be back to visit OSA. We would love to celebrate all she has done for our kids, our school and our community when we are able to come together in person. Staci deserved so much more, but at the very least we can do this. The ripple effects that Staci will have on our kids and our community will unfold for years to come. We wish her all the very best in her next adventure. The OSA Board is choosing a new leader, the new Executive Director has big shoes to fill. We hope that person can not only reflect the principles of diversity, equity, leadership from alongside instead of top down, but also represent our diverse community. A true commitment to equity means living it everyday in how we do the work. Thank you Staci, for living the word. Your APT. OSA Board Meeting tonight: The meeting can also be accessed by going to zoom.us/join and typing in the Meeting ID 159 766 296 found on the agenda. Following our remote learning protocols for internet safety, if the direct link isn't clicked, a password will be required. The password for this meeting is OSABOARD20.
https://www.konstella.com/school/Oakland%20School%20for%20the%20Arts/595d7dfbe4b0793064c964cd/activities/Thank%20you,%20Staci/5e96544e63da3fbabd0f4f87.html
No matter which health issue you may complain about to your doctor, getting sufficient sleep is often one of the primary remedies that she/he prescribes for the ailment in question. That proves just how imperative sleep is for our overall health and functionality. Lack of sufficient sleep (usually any amount less than 7 to 9 hours for adults or 8 to 10 hours for teens) is associated with a slew of health issues including reduced alertness, problems with memory, aggravation in symptoms of depression and anxiety, as well as an increased risk of obesity, diabetes, and heart disease. Given that more teens and adults are sleeping less than before and not achieving the recommended numbers of hours, more people are likely experiencing the detrimental effects of sleep deprivation. This is why researchers in Seattle recently looked into purposely extending sleep times for teens in the Seattle School District. Researchers found that by delaying school start times from 7:50am to 8:45am, students slept almost 34 minutes more on average per night thus bringing them closer to the recommended hours of sleep. The extra half an hour of sleep was found to also increase students’ grades by an average of 4.5 percent as well as improve attendance rates. The results make sense given the importance of sleep to brain function, mood, as well as overall well-being. The study in Seattle mentioned above demonstrates just how important it is to get the recommended hours of sleep every night. While the study shows how extra sleep can aid academic performance amongst teens, it wouldn’t be a far stretch to assume that adequate sleep will mean similar benefits for adults, whether it is an improvement in well-being, or better performance and less truancy at work. While delaying school start times and/or even getting to bed earlier seems like a good start to improving performance and health, it would also be helpful to look into our sleep habits and whether or not they favour good sleep. Sources: “Sleep Deprivation and Deficiency”. Retrieved from www.nhlbi.nih.gov. “Teen sleep linked to achievement (In Brief)” (2019). Retrieved from www.apa.org.
https://www.browncrawshaw.com/single-post/2019/04/25/the-benefits-of-getting-sufficient-sleep
Our client is a fast growing highly profitable multinational biopharmaceutical company with an exciting pipeline of drug compounds at an advanced stage in research. Reporting into the Exec Director Manufacturing Sciences within the Process Development and Manufacturing Sciences (PDMS) group the role will provide scientific and technical leadership to our external commercial partners for large and/or small molecule DS/DP manufacturing. - This position is responsible for providing strong scientific leadership for all aspects of technology transfer, process scale-up, process monitoring, and process troubleshooting to drug substance, drug product and finished product manufacturing activities for large and/or small molecules. This responsibility includes all process validation activities. - Other responsibilities will include cross-functional team leadership and / or membership, authoring technical reports and supporting CMC aspects of regulatory dossiers. The role will involve significant cross functional collaboration with other functions including R&D, external manufacturing and Quality, working towards existing and new product introduction and ensuring all processes are understood, robust, efficient and in control. - The role works in close collaboration with the product team’s Project lead who is the primary owner of the team processes, tools, metrics and all aspects of project management to ensure successful manufacture and supply of product to Patients. Job Spec - Demonstrated technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design to support process development/ support objectives - Lead development, maintenance and continuous improvement of process validation program for all DS and DP manufacturing processes. Provide technical input to Process Development for defining the critical process parameters of new processes - Experience of CMC regulatory requirements for pharmaceutical products and the evolving opportunities offered by application of QbD principles - Key member of the product External Manufacturing Product Team. Prioritizes technical or manufacturing issues for discussion & decision by the team - Works to the guidelines set out in the Product team charter. - Lead the technical agenda & relationship between the team and with the relevant CMO’s technical team at the site of manufacture. - Clearly and effectively communicate ideas and results, written and verbal, to technical and non-technical audiences. - Support other Product/Process Development and Manufacturing areas to ensure a smooth transfer of technologies and products to contract sites. - Ensure that all processes are in line with health, safety, environmental and quality requirements including regulations, policies, applicable guidelines and procedures. - Take ownership of planning, executing and reporting for all life cycle management (LCM) projects and technology transfers in support of process improvement and new product introductions. - Lead the development of knowledge of new pharmaceutical manufacturing processes as required in line with company business objectives - In conjunction with Quality Operations ensure that CMO’s are qualified and approved - Ensure Drug Substance, Drug Product, label & packaging and primary product contact materials are manufactured on time to the required quality - Collaborates with Development Team Leads to map the transition of responsibility for manufacturing from the development team to External Manufacturing Product Team as planning for Phase III supplies begins - Lead the Product team to identify and drive manufacturing process improvements and change management within CMOs - Wide-ranging experience in pharmaceutical manufacturing with a strong background in large and/or small molecule manufacturing technologies.
https://www.rftgroup.ie/jobs/director-manufacturing-sciences
Every patient sample is a story. That's why our Lab Ops team is focused on providing physicians with comprehensive genomic information about each person's cancer. Information that's as unique as the patients are. The insights discovered in our labs may help change their story. About the Job The Manager, Materials Management role within the Global Supply Chain Organization is responsible for managing the workflows and successful execution of daily incoming reagents and consumables inventory for FMI’s regulated laboratories. The operations which this position manages include, but are not limited to, receiving, quarantine, storage, cycle counting, control, and distribution of all regulated and non-regulated supplies; the Quality Systems Regulation (QSR) Kit manufacturing process; inbound and outbound packages; and general maintenance of loading dock and storerooms. This position leads a Materials Operations Team and builds and leads a team of supply chain specialists to ensure on time availability of supplies to support laboratory operations. This role partners closely with others in the Supply Chain function to ensure adherence to regulated workflows and accuracy of inventory transactions. This is a regulated position and additional information may be available from QA on the qualifications for this role pertaining to regulatory guidelines. Key Responsibilities • Build a team of Supply Chain Specialists and assign daily inventory management workflows. • Lead planning of daily receiving, QSR kit inventory, samples, general inventory, and Non-Good Manufacturing Practices (non-GMP) packages. • Conduct regular meetings with laboratory stakeholders to calibrate their needs and to anticipate changes in demands and process. • Address back-order supply challenges by: • Build, improve, and harmonize Manage Logistics and Distribution business processes at site and across the global network. • Provide metrics on consumption and trend analysis to lab stakeholders using Maximo and other inventory tracking tools. • Manage requests from customer groups for replenishment and packages in a timely manner meeting GMP. • Adhere to established Facilities Standard Operating Procedures (SOPs) in inventory, health and safety. • Ensure team adherence to regulated records, GMP, CLIA and QSR requirements. • Ensure communication responses to customer lab groups for materials requests. • Conduct team meetings discussing materials metrics and other materials-related matters on a monthly, quarterly and annual basis. • Conduct monthly, quarterly and annual financial counts for the whole site and work with the Finance Team on discrepancy investigations. • Work closely with Accounts Payable to navigate Invoice discrepancies. • Maintain adherence to environmental and health safety guidelines and policies. • Respond to daily requests via ticketing request system in a timely manner and utilize system to update status changes of inventory and non-GMP requests. • Conduct weekly inventory counts and report on consumption to assist with demand planning; communicate requisition status and delayed shipments. • Maintain a robust and accurate inventory within Maximo of regulated supplies and assist in generation of reports on consumption. • Create requisitions for inventory based on demand calculations and benchmarks. • Conduct daily and weekly audits of received inventory Purchase Orders (POs) to ensure Accounts Payable accuracy. • Investigate PO receipt discrepancies and suggest improvements to prevent reoccurrence. • Create Non-Conformance Reports and take steps for their resolutions, implementing changes with team to eliminate reoccurrence. • Maintain stockroom organization and ensure timely replenishment to shelved inventory bin locations. • Incorporate new inventory materials into existing process workflows. • Author Purchasing Specifications for new inventory materials within Master Control. • Manage return to vendor process from Return Materials Authorization (RMA). • Conduct 5S checks and maintain overall maintenance standards of the dock and stockrooms. • Manage sample waste stream adherence to established First-In-First Out (FIFO) disposal SOPs. • Other duties as assigned. Qualifications Basic Qualifications • High School Diploma, General Education Degree, Associate Degree • 5+ years of professional experience managing inventories Preferred Qualifications • Bachelor’s Degree • 5+ years of progressive experience managing inventories within a life science organization • 5+ years of leadership experience • Experience in shipping and receiving within good manufacturing practice validated environments • Experience in working with an enterprise resource planning inventory system • Competency in Inventory and Material Management or similar systems • Strong understanding of business priorities and ability to work well under pressure while maintaining a professional demeanor • Ability to lift up to 25 lbs. • Ability to work in a laboratory environment in the presence of chemicals and reagents • Competency in Microsoft Office and Microsoft Excel • Strong problem-solving skills demonstrated through a history of analyzing and developing solutions in coordination with lab stakeholders • Strong interpersonal skills that include effective use of written and oral communication and collaboration • Excellent organization and attention to detail • Understanding of HIPAA and importance of privacy of patient data • Commitment to FMI values: patients, innovation, collaboration, and passion Please be aware that Foundation Medicine mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law. Foundation Medicine, Inc. (FMI) began with an idea—to simplify the complex nature of cancer genomics, bringing cutting-edge science and technology to everyday cancer care. Our approach generates insights that help doctors match patients to more treatment options and helps accelerate the development of new therapies. Foundation Medicine is the culmination of talented people coming together to realize an important vision, and the work we do every day impacts real lives. Confidence, or the belief that we need to check every box before applying for a job, can sometimes hold us back from going after a role that inspires us. At Foundation Medicine there's no such thing as the 'perfect' applicant, and our company is a place where every employee can make an impact and continue to grow whatever background they may have or path they may have taken. So, as long as you meet the basic qualifications for a role, please apply if you see a position that would make you excited to come into Foundation Medicine every day and help us transform cancer care. Internal applicants, please use your FMI email address. Thank you Thank you for sending this job to your friend. Foundation Medicine is proud to be an Equal Opportunity and Affirmative Action employer and considers all qualified applicants for employment without regard to race, color, religion, sex, gender, sexual orientation, gender identity, ancestry, age, or national origin. Further, qualified applicants will not be discriminated against on the basis of disability or protected veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. See also FMI’s EEO Statement and EEO is the Law and Supplement. If you have a disability or special need that requires accommodation, please let us know by completing this form. (EOE/AAP Employer) To all recruitment agencies: Foundation Medicine does not accept agency resumes. Please do not forward resumes to our jobs alias, Foundation Medicine employees or any other organization location. Foundation Medicine is not responsible for any fees related to unsolicited resumes. Enter your details and we will notify you when new roles that might be a fit are posted!
https://careers.foundationmedicine.com/jobs/mgr-materials-management-global-supply-chain-san-diego-california-united-states
B.S. in Environmental Science One of the only programs in Texas with a soil science concentration, our environmental science bachelor’s degree takes a multidisciplinary, integrated approach to understanding biological, geological and human factors that affect environmental quality. Through broad coursework and hands-on learning experiences, you can explore and discover your environmental interests while preparing for a wide variety of jobs in environmental sciences. You can also specialize in an area of environmental sciences by choosing one of four concentrations: - Science - Soil Science - Geospatial Information Science (GIS) - Policy Our curriculum offers diverse opportunities to gain practical understanding of land and water resources, human impacts on the environment and environmental law and policies. Learn how to assess environmental conditions and provide environmental remediation using tools such as geographic information systems and remote sensing. As an environmental science major at Tarleton, you will gain marketable skills in effective environmental management to protect the health and future of our planet and our people. What is Environmental Science? Environmental science is an interdisciplinary field that integrates physical, biological and information sciences to study the effects of natural and man-made processes, as well as physical interactions of the planet, on the environment. Research helps environmental scientists identify, control or eliminate sources of pollutants or biological hazards. At Tarleton, we focus on addressing environmental and human concerns affecting soil, air and water quality, such as the diminishing availability of resources and the increasing frequency of droughts. Join us in helping to protect the environment, improve public health and inform government policies. Estimated Completion 120 Credit Hours (4 years) Application Process Cost Locations Available College What Can You Do With Your Bachelor’s Degree in Environmental Science? Entry-level jobs in environmental science, including scientist and specialist roles, are varied and plentiful. You could work in many different fields and industries, such as: - Soil Science and Conservation - Air and Water Quality Management - Environmental Compliance - Environmental Education and Communication - Environmental Consulting - Land Use and Land Restoration - Law and Regulation - Environmental Planning and Conservation - Waste Management Many of our graduates work for the USDA-Natural Resource Conservation Service, the Texas Commission on Environmental Quality, the U.S. Army Corps of Engineers, the Texas A&M University system and Lockheed Martin. Some attend law school for a career in environmental law. You may also be interested in attending graduate school in Tarleton’s MS in Agricultural and Natural Resource Sciences or MS in Environmental Science degree programs. How Much Do Environmental Science Graduates Make? The median annual salary for environmental scientists and specialists was over $71,000 in May 2018, according to the U.S. Bureau of Labor Statistics. Why Major in Environmental Science? We strive to meet the academic and professional needs of our students in a diverse and ever-changing field through coursework and applied learning experiences. A number of laboratory-based classes such as soil science and GIS provide valuable hands-on interactions in the classroom that connect theory with practice. Internships at a variety of government agencies, non-governmental organizations and private businesses give students valuable real-world experience. Many students conduct independent research projects with faculty and staff in areas such as soil science and water quality. Study abroad trips to Africa and Europe lend a global perspective to theory learned in the classroom. What Classes Will You Take as an Environmental Science Major? Our environmental sciences bachelor’s degree program provides you with diverse knowledge and skills through a variety of courses, including field work. Study topics such as ecological restoration for range and forest systems, soil science, environmental management, geographic information systems and land use management. Learn techniques in re-vegetation, prescribed fire and grazing, restoration of historic vegetation and more. View all required classes for the environmental science bachelor’s degree. Accreditations How Do You Get Started on Your Bachelor’s Degree in Environmental Science? Take the next step toward earning your bachelor’s degree in environmental science. We have the resources to help you get started. Get involved with student and professional organizations such as the Environmental Society and Intercollegiate Soil Judging Team. You can also join the Agriculture Living Learning Community for academic support and social activities with peers in similar areas of study. As an environmental science major, you’ll have access to state-of-the-art classrooms and labs for studying and research. Most learning on campus takes place in the Animal and Plant Sciences Center, featuring a soil science lab, and the 2,000-acre Tarleton Agriculture Center, which includes a horticulture center with greenhouses. Environmental science majors also have opportunities to gain hands-on experience at the Timberlake Ranch and Biological Field Station, Texas A&M AgriLife Research and Extension Center and the Southwest Regional Dairy Center. What Bachelor’s Degrees are Related to Environmental Science?
https://web.tarleton.edu/degrees/environmental-science-bs/
The term “rule out” is used by mental health professionals who are trying to make an accurate diagnosis. The symptoms of many mental health conditions are similar so before a clear diagnosis can be made, clinicians must rule out a variety of other conditions. If your teen is having trouble concentrating, a therapist may want to rule out ADHD or PTSD. Or, if your teen seems depressed, a mental health professional may want to rule out bipolar disorder before making a depression diagnosis. Mental illnesses aren’t always cut and dry. Professionals don’t simply use a checklist to arrive at a diagnosis. Instead, most conditions are diagnosed after a series of interviews where a clinician considers an individual’s background and environment. This is important because symptoms need to be taken into context. For example, a teen who is misbehaving at school, may be acting out because he has a learning disability or because he’s bullied, not necessarily because he has a behavior disorder. How to Get Help For Your Teen If you suspect your teen may have a mental health condition, seek professional help. Start by talking to your teen’s physician. Express any concerns you have about your teen’s mood or behavior. Your teen’s physician may make a referral to a therapist, psychiatrist, or other mental health professional. A thorough assessment and evaluation can help a clinician rule out specific mental health conditions while also arriving at an accurate diagnosis, if a diagnosis is warranted.
https://www.indianwomenlife.com/what-does-rule-out-mean/
Rest in Peace, Who's new | | WVIZ Presents: American Masters: Sketches of Frank Gehry Submitted by Norm Roulet on Tue, 09/26/2006 - 14:29. 09/27/2006 - 21:00 09/27/2006 - 23:00 Etc/GMT-4 Photo of Peter B. Lewis Building, by Frank Gehry, accented by Athena Tacha's Merging, 1986, of the Putnam Sculpture Collection. Photo by Evelyn Kiefer Catch this award winning documentary on WVIZ about world-renowned architect Frank Gehry, dessigner of the exceptional Peter B. Lewis Building of the Weatherhead School of Business at Case University... Wednesday, Sept. 27 at 9pm. About the documentary... Frank Gehry is that rare kind of architect who has garnered both critical acclaim and popular recognition. His designs dramatically blur the line between art and architecture; his sketches and models are the basis for dynamic structures and unpredictable interiors. Oscar-winner Sydney Pollack's first feature documentary, selected for the Cannes Film Festival, includes observations by Disney CEO Michael Eisner, musician Bob Geldof, actor Dennis Hopper, architect Phillip Johnson, artist Julian Schnabel and Gehry's psychiatrist. Peter B. Lewis (benefactor of Gehry's Case Western Reserve University building and an important, but never-built, residential design) also appears in the film. Location WVIZ Public TelevisionCleveland, OH United States See map: Google Maps | | Recent comments Popular content Today's: All time: Last viewed:
http://li326-157.members.linode.com/Sketches-of-Frank-Gehry
The government played both direct and indirect roles in the national economy. Although it allowed the private sector to control most of the country's economic assets, it found itself having to assume management of the sugar industry in the 1970s, a situation that remained unchanged as of 1987. The government, however, considered its primary role as one of facilitating economic development by exercising fiscal and monetary options, managing public sector investment, and creating an attractive environment for both public and private foreign capital. Following independence in 1983, St. Kitts and Nevis attempted to maintain a balance of revenues and expenses. By the mid-1980s, however, current expenditures and capital investment exceeded revenues. Large increases in public salaries, 45 percent in 1981 and 25 percent in 1986, were partially responsible for the growing deficit; tax receipts, however, did not realistically reflect fiscal requirements. To offset the resulting budget deficit, which reached 5 percent of GDP in 1984, the government cut capital expenditures, borrowed from domestic and foreign banks, and developed new revenue sources. Although the personal income tax was abolished in 1980, increased revenue was realized from two new taxes created in 1986, the Social Services Levy and the Employment Protection Levy. These new financial measures, in addition to import duties and utilities fees that had previously formed the basis of government revenue, allowed St. Kitts and Nevis to reverse its operational deficit and actually realize a small surplus by 1987. This was a critical development for maintaining the country's international credit rating and access to foreign loans. Because it was a member of a regional monetary authority, St. Kitts and Nevis had a limited ability to exercise control over the economy by manipulating money supply and interest rates. The nation's primary goals of growth and stability, however, were in accordance with those of other regional economies, and balanced growth of the money supply, which was managed by the ECCB, assisted the government in financing deficits and providing funds for public sector investment. The Social Security Scheme provided local public funds for budget and public investment loans. The government coordinated growth through a program of public sector investment, which managed foreign and domestic capital expenditures used for national development. The primary goal was to expand the country's economic base by moving away from sugar and toward tourism, manufacturing, and nonsugar agriculture. Public investment managers allocated funds to three major areas: directly productive sectors such as agriculture, industry, and tourism; economic infrastructure projects, including transportation, communications, and utilities; and social infrastructure, such as health, education, and housing. In the early 1980s, construction of economic infrastructure was emphasized to accommodate future growth in both manufacturing and tourism. Thirty percent of total expenditures were allocated to transportation. This resulted in the completion of a 250-kilometer road system, the Golden Rock International Airport, and a deep-water port in Basseterre. Communications were also upgraded in the 1980s and were considered good on both islands. A modern telephone system consisting of more than 2,400 telephones provided excellent international service by means of radio-relay links to both Antigua and St. Martin. St. Kitts had two AM stations: the government-owned Radio ZIZ on 555 kilohertz and the religious Radio Paradise with a powerful transmitter on 825 kilohertz. Channel 5, near Basseterre, was the principal television transmitter, and programs were rebroadcast through repeaters from the northern tip of St. Kitts on Channel 9 and Nevis on Channel 13. Other major projects in the early 1980s included construction of new schools, diversification of agriculture, and development of a manufacturing industry. Total allocation for these areas was about 39 percent of the budget; the remaining 61 percent was split among small projects in all three major areas. After 1984, with the completion of large portions of the supporting infrastructure, public sector investment was focused more intently on the productive sectors of the economy. Tourism received approximately 32 percent of total funds allocated through 1987; agriculture and industry followed with 12 percent and 14 percent, respectively. Economic and social infrastructure each received about 21 percent of total funding, with emphasis placed on developing new energy sources and upgrading educational facilities.
http://www.country-data.com/cgi-bin/query/r-3318.html
If you are lucky enough to be the owner of an older home, whether it is treasure from colonial times, or a pre-World World II home that you treasure, there is likely remodeling and renovation in your future. Preserving and enhancing an old home with a quality renovation can be both challenging and rewarding. Working with a qualified design professional can help make the process less stressful and ensure a successful renovation. 1. The First Challenge: Deciding What to Save. Your home probably has many features worth keeping. They may include hardwood flooring, ornate windows, doors and woodwork as well as custom cabinetry. Among the things not worth saving, however, are out-of-date plumbing, electrical wiring and rotted framing. On the exterior, if your home has been the victim of ugly additions over the years, you may want to make modifications to bring it back in line architecturally. Oftentimes, bad additions can be removed or reworked, and/or rooflines modified, to better coordinate with the original structure. 2. Develop a Vision, Make a Plan. The present layout of the house may not make the best use of available space, and you may need to remove some walls and erect others. A successful remodel starts with a plan and brings a house up to date while preserving what's best about it. Your designer will take a fresh look at your space as a whole, consider features you want to integrate into your design scheme, (such as an ornately carved staircase) and offer input on an arrangement that brings the house up to contemporary standards and improves the flow. Whether you add on or “stay within”, it's important to address those little flaws in your home that you may have dealt with for years: from waiting your turn to brush your teeth at a single bathroom sink, to bumping into each other in the kitchen when you are cleaning off the table, and stepping around a door that opens the wrong way. It’s this attention to details like this in home remodeling design that will make a difference in the quality of your life, once the construction dust settles and the workmen are gone. 3. Structural Concerns. While determining the size of your budget for desirable enhancements, keep in mind that you may need to allocate some monies to address structural issues. Antique homes are likely to have settled since their original date of construction, as evidenced by cracked walls, doors that don't work properly and sloping floors. If the foundation is intact, these characteristics of your home may be something that you find charming, are willing to live with, and can embrace in your design. But if the foundation is crumbling and leaks, you may want to take the opportunity to have the foundation replaced. This can be done in sections, and isn't as scary as it sounds! We do it all the time. 4. Plumbing and Electrical Upgrades. When renovating an old house it may make sense to consider overhaul some of the existing plumbing. If you have old cast iron or galvanized steel pipes that haven't corroded and developed blockages that restrict water flow, they probably soon will, and it may be a good idea to include replacing them during your renovation. Electrical standards have changed greatly over the years, and the systems in older houses rarely conform to today's codes. Renovation often offers the opportunity for increasing the electrical service to your home to meet the needs of contemporary living. Sometimes, the whole house must be rewired to replace out-of date/faulty wiring and electrical fixtures, provide enough outlets, offer proper grounding, and eliminate hazards. Your house will be safer and all things electrical will work better. You won't miss replacing blown fuses! 5. Upgrading Heating Systems. Renovation is a good time to address common old-house problems. Old houses almost always have insufficient or outdated heating, air conditioning and ventilation (HVAC) systems, and a good renovation plan will address these home comfort issues. Re-insulating with high-efficiency materials can fix hot and cold spots, minimize drafts, and lower energy costs. New windows and storms can enhance energy efficiency. Sometimes we just replace sashes, giving that energy efficiency boost, yet allowing original moldings with a zillion coats of paint to remain intact. 6. Old House Hazards. Some contain some asbestos, which was used for building materials for around 100 years before its cancer causing fibers were banned in the 1980s. Abatement is done by trained professionals. The other hazardous material common in vintage homes is lead, both lead paint and lead pipes. Your contractor will test for lead, and use "Lead-Safe" remodeling practices in areas where it is present. While it sometimes takes real guts to strip a house down to the studs, then build it back up again, it is truly fun and rewarding to bring new life to a historic home. Be patient. Pace yourself. Look forward to where you and your home are heading. Enjoy the journey towards the beautiful historic home you will have once the home improvements are complete.
https://www.clarkconstruction.net/blog-page/own-a-historic-home
Under the framework of Global Geothermal Alliance (GGA) – IRENA, the International Geothermal Association (IGA) and the World Bank co-organised a series of technical sessions with the Geological Surveys of the Caribbean Islands States, and other local stakeholders in the geothermal sector in the region. From the sessions conducted in St Lucia, an expert group looked to gather information to develop an understanding of the inventory of existing geothermal fields and resource recovery estimates in St Lucia, Guadeloupe (French territory), Saint kits & Nevis, Montserrat, Grenada and Dominica. With this information, the group intends to support the five islands in classifying the resource estimates in accordance with the Internationally acceptable guidelines of the UNFC. The group also gathered specific datasets on sub-surface geology (ideally up to 10 km depth showing sedimentary basins - thickness, density, thermal conductivity and permeability) and existing bottom hole temperature logs for the selected Caribbean Islands countries – required to model and develop high resolution vertical temperature maps in 1km vertical intervals up to a depth of 10km. The result will be digitalised and integrated into the IRENA’s Global Atlas for Renewable Energy platform to enrich the geothermal component. Incorporating VRE into long-term planning in Arab Countries 21 April 2019 |Amman, Jordan IRENA, in close collaboration with the League of Arab States (LAS) and Regional Center for Renewable... Clean Energy for Health Care Conference 24 April 2019 |Nairobi, Kenya A conference to raise awareness among policy makers about the opportunities provided by... Falling RE costs: How Can Modellers Keep up? 13 May 2019 |Bonn, Germany Organized by IRENA and IEA PVPS, this workshop targets leading international and local renewable...
https://www.irena.org/events/2018/Dec/Regional-Geothermal-Resource-Data-Gathering-UNFC-Classification-and-Training-Workshop
This is the second of the COPD Pulmonary Rehabilitation audit reports, published as part of the National COPD Audit Programme, detailing national data relating to Pulmonary Rehabilitation delivered in England and Wales. It also documents attainment against relevant Pulmonary Rehabilitation guidelines and quality standards as published by the British Thoracic Society (BTS) in 2013 and 2014. Key recommendations These recommendations are directed collectively to commissioners, provider organisations, referrers for PR and to PR practitioners themselves. They are also relevant to patients, patient support groups and voluntary organisations. Implementing these recommendations will require discussions between commissioners and providers, and we suggest that the findings of the audit are considered promptly at board level in these organisations so that these discussions are rapidly initiated. Commissioners and providers should ensure they are working closely with patients, carers and patient representatives when discussing and implementing these recommendations. This report identifies two broad areas for improvement: firstly action to improve referral and access to PR; and secondly action to improve the quality of treatment when patients attend PR. - Improving access to PR - Providers and commissioners should ensure that robust referral pathways for PR are in place and that PR programmes have sufficient capacity to assess and enrol all patients within 3 months of receipt of referral. - Referral pathways should be developed to ensure all patients hospitalised for acute exacerbations of COPD are offered referral for PR and that those who take up this offer are enrolled within 1 month of discharge. - Providers and commissioners should work together to make referrers (including those working in general practice and community services) and patients fully aware of the benefits of PR, to encourage referral. - PR programmes should take steps to ensure their services are sufficiently flexible to encourage patients who are referred for PR to complete treatment. - Improving the care provided by PR programmes - a. All PR programmes should examine and compare their local data with accepted thresholds for clinically important changes in the clinical outcomes of PR and with the national picture. For all programmes, this should prompt the development of a local plan aimed at improving the quality of the service provided. - PR programmes locally should review their processes to ensure all patients attending a discharge assessment for PR are provided with a written, individualised plan for ongoing exercise. - c. PR programmes locally should review their processes to ensure all outcome assessments are performed to acceptable technical standards (4). The report is relevant to anyone with an interest in COPD. It provides a comprehensive picture of Pulmonary Rehabilitation services, and will enable lay people, as well as experts, to understand how COPD services function currently, and where change needs to occur. The information, key findings and recommendations outlined in the report are designed to provide readers with a basis for identifying areas in need of change and to facilitate development of improvement programmes that are relevant not only to Pulmonary Rehabilitation programmes but also to commissioners and policymakers.
https://www.rcplondon.ac.uk/projects/outputs/pulmonary-rehabilitation-steps-breathe-better
GE Universal Relay family of devices has been detected to be holding severe security vulnerabilities as is notified by the U.S. Cybersecurity and Infrastructure Security Agency (CISA). GE Universal Relay devices and their vulnerabilities: To the unaware, the GE’s Universal Relay devices and systems supply integrated monitoring and metering, high-speed communications, and offer simplified power management for the protection of critical assets. Analysis of the security vulnerabilities in GE Universal Relay devices put forth that accomplished exploitation of these vulnerabilities can facilitate malicious actors to gain access to sensitive data, reboot the Universal Relay devices, obtain privileged access or enable a DOS i.e denial-of-service attack. In the report published by CISA, it was found that the security vulnerabilities that compromised these Universal Relay devices included the devices like the B30, B90, C30, C60, C70, C95, D30, D60, F35, F60, G30, G60, L30, L60, L90, M60, N60, T35, and T60. Deploying fixes for GE’s Universal Relays: These vulnerabilities had been seemingly addressed by GE in an update released for the Universal Relay firmware that was made available back in December 2020. In the security patches deployed in the update, an aggregate of nine vulnerabilities were resolved. One of the most significant vulnerabilities that were patched in the update concerns an insecure default variable initialization, referring to the initialization of an internal variable in the software with an insecure value. The vulnerability (CVE-2021-27426) is also rated 9.8 out of 10, making it a critical issue. Reportedly, a malicious actor could exploit this vulnerability by transmitting a custom-built request to bypass access restrictions. Another severe vulnerability, tracked as CVE-2021-27430, is a consequence of unused hard-coded credentials in the bootloader binary that could be potentially exploited by malicious actors. Also fixed by GE is another high severity flaw (CVE-2021-27428) that could permit an unauthorized user to upgrade firmware without appropriate privileges. Amongst the remaining four vulnerabilities, two of those were concluded as improper input validations, and the other two, a result of exposure of sensitive information to unauthorized users. These vulnerabilities could potentially compromise GE Universal Relay devices by exposing them to cross-site scripting attacks, enabling malicious actors to access critical data without authentication, and even render the webserver unresponsive. Concluding, all versions of GE Universal Relay firmware preceding 8.1x have been detected to be implementing poor encryption and MAC algorithms for SSH communications, which could lead to severe brute force attack scenarios.
https://cyberdaily.securelayer7.net/ges-universal-relay-devices-vulnerabilities-critically-addressed-by-cisa/
If you need a document or text translating from Spanish or Portuguese into English, then please request a quote by getting in touch here. The price quoted will take into account the document type (PDF, Word, Powerpoint, .txt, etc.), formatting, urgency, volume of text, and complexity or technicality of the subject matter. Interpreting If you require an interpreter to mediate between English and Spanish or English and Portuguese speakers, then please feel free to get in touch here in order to establish the specific requirements of your meeting or event. Transcription If you have an audio or media file in English, Spanish or Portuguese and you require either a written transcript in the same language and/or a translation of the content, then please get in touch here to discuss the project in greater detail. Subtitling I can translate audio or video material and then dub the subtitles over the content using Aegisub software. Proofreading & Editing I can proofread and revise existing translations as an additional quality check. Similarly, I can proofread and revise essays, academic texts and culturally specific content for non-native English speakers. Localisation Localisation involves not only translating words for a new audience, but rather the total adaptation of a concept or idea to ensure originality in the new culture or local market. If you are launching something into a new and distinct market, then please feel free to discuss your project further by getting in touch here.
https://www.njftranslation.com/language-services
Author pages are created from data sourced from our academic publisher partnerships and public sources. - Publications - Influence Share This Author Mental imagery - J. Pearson, S. Kosslyn - Psychology, Medicine - Front. Psychol. - 3 January 1990 An inspiringly broad range of work that focuses on mental imagery is introduced, which provides theoretical insights and an overview of the state of empirical understanding, where it is heading, and how mental imagery relates to other cognitive and sensory functions. Expand TLDR Mental Imagery: Functional Mechanisms and Clinical Applications - J. Pearson, Thomas Naselaris, E. Holmes, S. Kosslyn - Psychology, Medicine - Trends in Cognitive Sciences - 1 October 2015 Recent translational and clinical research reveals the pivotal role that imagery plays in many mental disorders and suggests how clinicians can utilize imagery in treatment. Expand TLDR The Role of Frontal and Parietal Brain Areas in Bistable Perception - T. Knapen, J. Brascamp, J. Pearson, R. van Ee, R. Blake - Psychology, Medicine - The Journal of Neuroscience - 13 July 2011 The results are consistent with the view that at least a component of rFPC activation during bistable perception reflects a response to perceptual transitions, both real and yoked, rather than their cause. Expand TLDR Sensory memory for ambiguous vision - J. Pearson, J. Brascamp - Psychology, Medicine - Trends in Cognitive Sciences - 1 September 2008 Although a trace is evident after a single perceptual instance, the trace builds over many separate stimulus presentations, indicating a flexible, variable-length time-course. Expand TLDR The Functional Impact of Mental Imagery on Conscious Perception - J. Pearson, C. Clifford, F. Tong - Biology, Medicine - Current Biology - 8 July 2008 It is demonstrated that imagery, in the absence of any incoming visual signals, leads to the formation of a short-term sensory trace that can bias future perception, suggesting a means by which high-level processes that support imagination and memory retrieval may shape low-level sensory representations. Expand TLDR Human brain networks function in connectome-specific harmonic waves - S. Atasoy, Isaac Donnelly, J. Pearson - Computer Science, Medicine - Nature communications - 21 January 2016 It is reported that functional networks of thehuman brain are predicted by harmonic patterns, ubiquitous throughout nature, steered by the anatomy of the human cerebral cortex, the human connectome, in a new frequency-specific representation of cortical activity, that is called ‘connectome harmonics’. Expand TLDR Mental Imagery and Visual Working Memory - Rebecca Keogh, J. Pearson - Psychology, Medicine - PloS one - 14 December 2011 It is shown that performance in visual working memory - but not iconic visual memory - can be predicted by the strength of mental imagery as assessed with binocular rivalry in a given individual, suggesting a dichotomy in strategies for visualWorking memory. Expand TLDR Intermittent ambiguous stimuli: implicit memory causes periodic perceptual alternations. - J. Brascamp, J. Pearson, R. Blake, A. V. van den Berg - Psychology, Medicine - Journal of vision - 1 March 2009 Perception is studied during long sessions of intermittent presentation to demonstrate that, rather than causing truly stable perception, intermittent presentation gives rise to a perceptual alternation cycle with its own characteristics and dependencies, different from those during continuous presentation. Expand TLDR Determinants of visual awareness following interruptions during rivalry. - J. Pearson, C. Clifford - Psychology, Medicine - Journal of vision - 19 March 2004 It is speculated that perceptual memory across interruptions in rivalry may involve the same neural representations as visual competition during rivalry, and be able to operate at both monocular and binocular levels, much like the mechanisms operating during continuous viewing of rivalrous stimuli. Expand TLDR The heterogeneity of mental representation: Ending the imagery debate - J. Pearson, S. Kosslyn - Medicine, Psychology - Proceedings of the National Academy of Sciences - 14 July 2015 Recent evidence is described that humans do not always rely on propositional internal representations but, instead, can also rely on at least one other format: depictive representation. Expand TLDR ... 1 2 3 4 5 ...
https://www.semanticscholar.org/author/J.-Pearson/5197851
The debate over the existence of recovered memories remains a divisive issue for mental health practitioners and cognitive scientists, in part due to a limited understanding of the processes underlying motivated forgetting behaviors. The present study argues motivated forgetting is best understood in the context of normal memory processes. For instance, previous studies utilizing a retrieval-biasing procedure, referred to as the dropout procedure, have shown that practiced avoidance activities can create profound memory blocks for lists of words and short stories. Experiment 1 addressed whether these forgetting effects extend to memories with greater personal significance, such as autobiographical memories. In Experiment 1 participants studied descriptions of target and non-target autobiographical events. Non-target memory descriptions were then re-presented several times during the practiced avoidance phase of the experiment. In contrast, target memory descriptions were “dropped out” of the study list and did not receive extra study exposures. On a subsequent memory test, significant memory deficits were observed for target memory descriptions when performance was compared to a control condition that did not participate in the practiced avoidance phase. These results provided evidence that emotionally-laden autobiographical memories are susceptible to memory blocks, and further support the theoretical contention that practiced avoidance could be used to regulate unwanted memories. The present study also examined how and under what circumstances forgetting effects following the dropout procedure occur. Experiments 2 and 3 report dissociable effects of avoidance activities involving competitive retrieval practice and incidental re-presentations of non-target items. Although both avoidance tasks resulted in significant forgetting effects, greater memory impairments were observed for target items following competitive retrieval practice of non-target items. This finding was consistent with predictions from inhibition theory, and suggests that different avoidance activities may recruit different forgetting mechanisms. Finally, Experiments 2 and 3 examined the relationship between individual differences in repressive coping style and forgetting effects produced by the dropout procedure. Participants assessed to be repressive copers were more likely to forget negative target items, but only under conditions where avoidance tasks involved competitive retrieval practice. This finding was consistent with previous research demonstrating enhanced memory control abilities among repressive copers. Handy, Justin Dean (2015). The Continued March Towards Ecological Validity in Laboratory Studies of Blocked and Recovered Memories. Doctoral dissertation, Texas A & M University. Available electronically from http : / /hdl .handle .net /1969 .1 /155158.
https://oaktrust.library.tamu.edu/handle/1969.1/155158
. Visual tracking or eye tracking is the perceptual process of following a visual stimulus along a trajectory and involves complex mechanisms for coordinating the activity of the visual system Investigation involve measuring either the point of gaze ("where we are looking") or the motion of an eye relative to the head. An eye tracker is a device for measuring eye positions and eye movements. Eye trackers are used in research on the visual system, in psychology, in cognitive linguistics and in product design. There are a number of methods for measuring eye movements. The most popular variant uses video images from which the eye position is extracted. Other methods use search coils or are based on the electrooculogram. History Edit In the 1800s, studies of eye movements were made using direct observations. In 1879 in Paris, Louis Émile Javal observed that reading does not involve a smooth sweeping of the eyes along the text, as previously assumed, but a series of short stops (called fixations) and quick saccades. This observation raised important questions about reading, which were explored during the 1900s: On which words do the eyes stop? For how long? When does it regress back to already seen words? Huey built what might be the first eye tracker, using a sort of contact lens with a hole for the pupil. The lens was connected to an aluminum pointer that moved in response to the movements of the eye. Huey studied and quantified regressions (only a small proportion of saccades are regressions), and show that only a portion of the words in a sentence were actually fixated. The first non-intrusive eye trackers were built by George Buswell in Chicago, using beams of light that was reflected on the eye and then recording on film. Buswell made systematic studies into reading and picture viewing. In the 1950s, Alfred L. Yarbus did important eye tracking research and his 1967 book is one of the most quoted eye tracking publications ever. For example he showed the task given to a subject has a very large influence on the subject's eye movements. He also wrote about the relation between fixations and interest: - "All the records (…) show conclusively that the character of the eye movements is either completely independent of or only very slightly dependent on the material of the picture and how it was made, provided that it is flat or nearly flat." The cyclical pattern in the examination of pictures "is dependent not only on what is shown on the picture, but also on the problem facing the observer and the information that he hopes to gain from the picture." - "Records of eye movements show that the observer's attention is usually held only by certain elements of the picture. (…) Eye movements reflect the human thought processes; so the observer's thought may be followed to some extent from records of eye movements (the thought accompanying the examination of the particular object). It is easy to determine from these records which elements attract the observer's eye (and, consequently, his thought), in what order, and how often." - "The observer's attention is frequently drawn to elements which do not give important information but which, in his opinion, may do so. Often an observer will focus his attention on elements that are unusual in the particular circumstances, unfamiliar, incomprehensible, and so on." - "(…) when changing its points of fixation, the observer's eye repeatedly returns to the same elements of the picture. Additional time spent on perception is not used to examine the secondary elements, but to reexamine the most important elements." In the 1970s, eye tracking research expanded rapidly, particularly reading research. A good overview of the research in this period is given by Rayner.. In 1980, Just and Carpenter formulated the influential Strong eye-mind Hypothesis, the hypothesis that "there is no appreciable lag between what is fixated and what is processed". If this hypothesis is correct, then when a subject looks at a word or object, he or she also thinks about (process cognitively), and for exactly as long as the recorded fixation. The hypothesis is too often today taken for granted by beginning eye tracker researchers. During the 1980s, the eye-mind hypothesis was often questioned in light of covert attention, the attention to something that one is not looking at, which people often do. If covert attention is common during eye tracking recordings, the resulting scan path and fixation patterns would often show not where our attention has been, but only where the eye has been looking, and so eye tracking would not indicate cognitive processing. According to Hoffman, current consensus is that visual attention is always slightly (100 to 250 ms) ahead of the eye. But as soon as attention moves to a new position, the eyes will want to follow. We still cannot infer specific cognitive processes directly from a fixation on a particular object in a scene. For instance, a fixation on a face in a picture may indicate recognition, liking, dislike, puzzlement etc. Therefore eye tracking is often coupled with other methodologies, such as introspective verbal protocols. Technologies and techniquesEdit The most widely used current designs are video-based eye trackers. A camera focuses on one or both eyes and records their movement as the viewer looks at some kind of stimulus. Most modern eye-trackers use contrast to locate the center of the pupil and use infrared and near-infrared non-collumnated light to create a corneal reflection (CR). The vector between these two features can be used to compute gaze intersection with a surface after a simple calibration for an individual. Two general types of eye tracking techniques are used: Bright Pupil and Dark Pupil. Their difference is based on the location of the illumination source with respect to the optics. If the illumination is coaxial with the optical path, then the eye acts as a retroreflector as the light reflects off the retina creating a bright pupil effect similar to red eye. If the illumination source is offset from the optical path, then the pupil appears dark. Bright Pupil tracking creates greater iris/pupil contrast allowing for more robust eye tracking with all iris pigmentation and greatly reduces interference caused by eyelashes and other obscuring features. It also allows for tracking in lighting conditions ranging from total darkness to very bright. But bright pupil techniques are not effective for tracking outdoors as extraneous IR sources interfere with monitoring. Eye tracking setups vary greatly; some are head-mounted, some require the head to be stable (for example, with a chin rest), and some function remotely and automatically track the head during motion. Most use a sampling rate of at least 30 Hz. Although 50/60 Hz is most common, today many video-based eye trackers run at 240, 350 or even 1000/1250 Hz, which is needed in order to capture the detail of the very rapid eye movements during reading, or during studies of neurology. Eye movements are typically divided into fixations and saccades, when the eye gaze pauses in a certain position, and when it moves to another position, respectively. The resulting series of fixations and saccades is called a scanpath. Most information from the eye is made available during a fixation, but not during a saccade.[How to reference and link to summary or text] The central one or two degrees of the visual angle (the fovea) provide the bulk of visual information; the input from larger eccentricities (the periphery) is less informative. Hence, the locations of fixations along a scanpath show what information loci on the stimulus were processed during an eye tracking session. On average, fixations last for around 200 ms during the reading of linguistic text, and 350 ms during the viewing of a scene. Preparing a saccade towards a new goal takes around 200 milliseconds.[How to reference and link to summary or text] Scanpaths are useful for analyzing cognitive intent, interest, and salience. Other biological factors (some as simple as gender) may affect the scanpath as well. Eye tracking in HCI typically investigates the scanpath for usability purposes, or as a method of input in gaze-contingent displays, also known as gaze-based interfaces. Commercial technologyEdit There are two primary components to most eye tracking studies: Statistical analysis and graphic rendering. These are both based mainly on eye fixations of specific elements. Statistical analyses generally sum the number of eye data observations that fall in a particular region. Figure 1 shows the results of an analysis by a commercial software package showing the relative probability of eye fixation on each feature in a website. This allows for a broad analysis of which site elements received attention and which ones were ignored. Other behaviors such as blinks, saccades and cognitive engagement can be reported by commercial software packages. Statistical comparisons can be made to test competitors, prototypes or subtle changes to a web design. They can also be used to compare participants in different demographic groups. Statistical analyses quantify where users look, sometimes directly, and sometimes based on models of higher-order phenomena (e.g. cognitive engagement ). In addition to statistical analysis, it is often useful to provide visual depictions of eye tracking results. The simplest method is to create a video of an eye tracking testing session with the gaze of a participant superimposed upon it. This allows one to effectively see through the eyes of the consumer during interaction with a target medium. Examples of such videos can be found in the external links section. Another method graphically depicts the scanpath of a single participant during a given time interval. The image in figure 2 shows each fixation and eye movement of a participant during a search on a virtual shelf display of breakfast cereals, analyzed and rendered with a commercial software package. Each color represents one second of viewing time, allowing the client to determine the order in which products are seen. Graphics such as these are used as evidence of specific trends in visual behavior. A similar method sums the eye data of multiple participants during a given time interval as a heat map. The heat map shown in figure 3 was produced by a commercial software package, and shows the density of eye fixations for several participants superimposed on the original stimulus, in this case a magazine cover. Red and orange spots represent areas with high densities of eye fixations. This allows the client to examine which regions in general attract the focus of the consumer. All of these methods are often used in conjunction and incorporated with traditional marketing research measures to produce a comprehensive investigation of commercial value. ApplicationsEdit A wide variety of disciplines use eye tracking techniques, including cognitive science, psychology (notably psycholinguistics, the visual world paradigm), human-computer interaction (HCI), marketing research and medical research (neurological diagnosis). Specific applications include the tracking eye movement in language reading, music reading, the perception of advertising, and the playing of sport. Uses include: - Cognitive Studies - Medical Research - Human Factors - Computer Usability - Translation Process Research - Vehicle Simulators - In-vehicle Research - Training Simulators - Virtual Reality - Adult Research - Infant Research - Adolescent Research - Geriatric Research - Primate Research - Sports Training - fMRI / MEG / EEG - Commercial eye tracking (web usability, advertising, marketing, automotive, etc) - finding good clues - Communication systems for disabled - Improved image and video communications Commercial applicationsEdit In recent years, the increased sophistication and accessibility of eye tracking technologies have generated a great deal of interest in the commercial sector. Applications include web usability, advertising, sponsorship, package design and automotive engineering. In general, commercial eye tracking studies function by presenting a target stimulus to a sample of consumers while an eye tracker is used to record the activity of the eye. Examples of target stimuli may include websites, television programs, sporting events, films, commercials, magazines, newspapers, packages, shelf Displays, consumer systems (ATMs, checkout systems, kiosks), and software. The resulting data can be statistically analyzed and graphically rendered to provide evidence of specific visual patterns. By examining fixations, saccades, pupil dilation, blinks and a variety of other behaviors researchers can determine a great deal about the effectiveness of a given medium or product. While some companies complete this type of research internally, there are many private companies that offer eye tracking services and analysis. The most prominent field of commercial eye tracking research is web usability. While traditional usability techniques are often quite powerful in providing information on clicking and scrolling patterns, eye tracking offers the ability to analyze user interaction between the clicks. This provides valuable insight into which features are the most eye-catching, which features cause confusion and which ones are ignored altogether. Specifically, eye tracking can be used to assess search efficiency, branding, online advertisements, navigation usability, overall design and many other site components. Analyses may target a prototype or competitor site in addition to the main client site. Eye tracking is commonly used in a variety of different advertising media. Commercials, print ads, online ads and sponsored programs are all conducive to analysis with current eye tracking technology. Analyses focus on visibility of a target product or logo in the context of a magazine, newspaper, website, or televised event. This allows researchers to assess in great detail how often a sample of consumers fixates on the target logo, product or ad. In this way, an advertiser can quantify the success of a given campaign in terms of actual visual attention. Eye tracking provides package designers with the opportunity to examine the visual behavior of a consumer while interacting with a target package. This may be used to analyze distinctiveness, attractiveness and the tendency of the package to be chosen for purchase. Eye tracking is often utilized while the target product is in the prototype stage. Prototypes are tested against each other and competitors to examine which specific elements are associated with high visibility and appeal. One of the most promising applications of eye tracking research is in the field of automotive design. Research is currently underway to integrate eye tracking cameras into automobiles. The goal of this endeavor is to provide the vehicle with the capacity to assess in real-time the visual behavior of the driver. The National Highway Traffic Safety Administration (NHTSA) estimates that drowsiness is the primary causal factor in 100,000 police-reported accidents per year. Another NHTSA study suggests that 80% of collisions occur within three seconds of a distraction. By equipping automobiles with the ability to monitor drowsiness, inattention, and cognitive engagement driving safety could be dramatically enhanced. Lexus claims to have equipped its LS 460 with the first driver monitor system in 2006, providing a warning if the driver takes his or her eye off the road. Since 2005 Eye tracking is used in Communication systems for disabled allowing the user to speak, mail, surf the web and so with only the eyes as tool. Eye control works even when the user has involuntary movement as a result of CP or other disability, those who wear glasses or many other characteristics that limit the effectiveness of older eye control systems. Research: Journals, conferences, publicationsEdit Because of the wide variety of application areas, there are few common research journals or conferences for eye-tracking research. Results from research on eye movements often end up in very different channels. There are a number of recurring research conferences, however. ECEM - the European Conference on Eye Movements, biannual SWAET - the Scandinavian Workshop on Applied Eye-tracking, annual Vision in Vehicles, biannual ETRA - Eyetracking Research and Applications, biannual COGAIN - Communication by Gaze Interaction, annual Tracker types Edit Eye trackers measure rotations of the eye in one of several ways, but principally they fall into three categories. One type uses an attachment to the eye, such as a special contact lens with an embedded mirror or magnetic field sensor, and the movement of the attachment is measured with the assumption that it does not slip significantly as the eye rotates. Measurements with tight fitting contact lenses have provided extremely sensitive recordings of eye movement, and magnetic search coils are the method of choice for researchers studying the dynamics and underlying physiology of eye movements. The second broad category uses some non-contact, optical method for measuring eye motion. Light, typically infrared, is reflected from the eye and sensed by a video camera or some other specially designed optical sensor. The information is then analyzed to extract eye rotation from changes in reflections. Video based eye trackers typically use the corneal reflection (the first Purkinje image) and the center of the pupil as features to track over time. A more sensitive type of eye tracker, the dual-Purkinje eye tracker, uses reflections from the front of the cornea (first Purkinje image) and the back of the lens (fourth Purkinje image) as features to track. A still more sensitive method of tracking is to image features from inside the eye, such as the retinal blood vessels, and follow these features as the eye rotates. Optical methods, particularly those based on video recording, are widely used for gaze tracking and are favored for being non-invasive and inexpensive. The third category uses electrical potentials measured with contact electrodes placed near the eyes. The most common variant of this is the electro-oculogram (EOG) and is based on the fact that the eye has a standing electrical potential, with the cornea being positive relative to the retina. This potential is not constant, however, and its variation causes the EOG to be somewhat unreliable for measuring slow eye movements and fixed gaze positions. The EOG is most useful for measuring the rapid, saccadic eye movements associated with gaze shifts and is the method of choice for measuring REM during sleep. Eye tracking vs. gaze tracking Edit Eye trackers necessarily measure the rotation of the eye with respect to the measuring system. If the measuring system is head mounted, as with EOG, then eye-in-head angles are measured. If the measuring system is table mounted, as with scleral search coils or table mounted camera (“remote”) systems, then gaze angles are measured. In many applications, the head position is fixed using a bite bar, a forehead support or something similar, so that eye position and gaze are the same. In other cases, the head is free to move, and head movements are measured with systems such as magnetic or video based head trackers. For head-mounted trackers, head position and direction are added to eye-in-head direction to determine gaze direction. For table-mounted systems, such as search coils, head direction is subtracted from gaze direction to determine eye-in-head position. Applications Edit A great deal of research has gone into studies of the mechanisms and dynamics of eye rotation, but the goal of eye tracking is most often to estimate gaze direction. Users may be interested in what features of an image draw the eye, for example. It is important to realize that the eye tracker does not provide absolute gaze direction, but rather can only measure changes in gaze direction. In order to know precisely what a subject is looking at, some calibration procedure is required in which the subject looks at a point or series of points, while the eye tracker records the value that corresponds to each gaze position. (Even those techniques that track features of the retina cannot provide exact gaze direction because there is no specific anatomical feature that marks the exact point where the visual axis meets the retina, if indeed there is such a single, stable point.) An accurate and reliable calibration is essential for obtaining valid and repeatable eye movement data, and this can be a significant challenge for non-verbal subjects or those who have unstable gaze. Each method of eye tracking has advantages and disadvantages, and the choice of an eye tracking system depends on considerations of cost and application. There is a trade-off between cost and sensitivity, with the most sensitive systems costing many tens of thousands of dollars and requiring considerable expertise to operate properly. Advances in computer and video technology have led to the development of relatively low cost systems that are useful for many applications and fairly easy to use. Interpretation of the results still requires some level of expertise, however, because a misaligned or poorly calibrated system can produce wildly erroneous data. Choosing an eye tracker Edit One difficulty in evaluating an eye tracking system is that the eye is never still, and it can be difficult to distinguish the tiny, but rapid and somewhat chaotic movements associated with fixation from noise sources in the eye tracking mechanism itself. One useful evaluation technique is to record from the two eyes simultaneously and compare the vertical rotation records. The two eyes of a normal subject are very tightly coordinated and vertical gaze directions typically agree to within +/- 2 minutes of arc (RMS of vertical position difference) during steady fixation. A properly functioning and sensitive eye tracking system will show this level of agreement between the two eyes, and any differences much larger than this can usually be attributed to measurement error. See alsoEdit - Eye movement - Eye movement in language reading - Eye movement in music reading - Fovea - Gaze-contingency paradigm - Peripheral vision - Visual discrimination - Visual perception NotesEdit - ↑ Reported in Huey 1908/1968. - ↑ Buswell (1922, 1937) - ↑ (1935) - ↑ Yarbus (1967) - ↑ (Yarbus 1967: 190) - ↑ (Yarbus 1967:194) - ↑ (Yarbus 1967:190). - ↑ (Yarbus 1967:191). - ↑ (Yarbus 1967:193). - ↑ Rayner (1978) - ↑ Just and Carpenter (1980) - ↑ Posner (1980) - ↑ Hoffman 1998 - ↑ Deubel and Schneider 1996 - ↑ Holsanova 2007 - ↑ See, e.g., newspaper reading studies. - ↑ LS460 achieves a world-first in preventative safety. (HTML) NewCarNet.co.uk. URL accessed on 2007-04-08. ReferencesEdit - Adler FH & Fliegelman (1934). Influence of fixation on the visual acuity. Arch. Ophthalmology 12, 475. - Buswell, G.T. (1922). Fundamental reading habits: A study of their development. Chicago, IL: University of Chicago Press. - Buswell G.T. (1935). How People Look at Pictures. Chicago: Univ. Chicago Press 137–55. Hillsdale, NJ: Erlbaum - Buswell, G.T. (1937). How adults read. Chicago, IL: University of Chicago Press. - Carpenter, Roger H.S.; Movements of the Eyes (2nd ed.). Pion Ltd, London, 1988. ISBN 0-85086-109-8. - Cornsweet TN, Crane HD. (1973) Accurate two-dimensional eye tracker using first and fourth Purkinje images. J Opt Soc Am. 63, 921-8. - Cornsweet TN. (1958). New technique for the measurement of small eye movements. JOSA 48, 808-811. - Deubel, H. & Schneider, W.X. (1996) Saccade target selection and object recognition: Evidence for a common attentional mechanism. Vision Research, 36, 1827-1837. - Duchowski, A. T., "A Breadth-First Survey of Eye Tracking Applications", Behavior Research Methods, Instruments, & Computers (BRMIC), 34(4), November 2002, pp.455-470. - Eizenman M, Hallett PE, Frecker RC. (1985). Power spectra for ocular drift and tremor. Vision Res. 25, 1635-40 - Ferguson RD (1998). Servo tracking system utilizing phase-sensitive detection of reflectance variations. US Patent # 5,767,941 - Hammer DX, Ferguson RD, Magill JC, White MA, Elsner AE, Webb RH. (2003) Compact scanning laser ophthalmoscope with high-speed retinal tracker. Appl Opt. 42, 4621-32. - Hoffman, J. E. (1998). Visual attention and eye movements. In H. Pashler (ed.), Attention (pp. 119-154). Hove, UK: Psychology Press. - Holsanova, J. (forthcoming) Picture viewing and picture descriptions, Benjamins. - Huey, E.B. (1968). The psychology and pedagogy of reading. Cambridge, MA: MIT Press. (Originally published 1908) - Jacob, R. J. K. & Karn, K. S. (2003). Eye Tracking in Human-Computer Interaction and Usability Research: Ready to Deliver the Promises. In R. Radach, J. Hyona, & H. Deubel (eds.), The mind's eye: cognitive and applied aspects of eye movement research (pp.573-605). Boston: North-Holland/Elsevier. - Just MA, Carpenter PA (1980) A theory of reading: from eye fixation to comprehension. Psychol Rev 87:329–354 - Mulligan, JB, (1997). Recovery of Motion Parameters from Distortions in Scanned Images. Proceedings of the NASA Image Registration Workshop (IRW97), NASA Goddard Space Flight Center, MD - Ott D & Daunicht WJ (1992). Eye movement measurement with the scanning laser ophthalmoscope. Clin. Vision Sci. 7, 551-556. - Posner, M. I. (1980) Orienting of attention. Quarterly Journal of Experimental Psychology 32: 3-25. - Rayner, K. (1978). Eye movements in reading and information processing. Psychological Bulletin, 85, 618-660 - Rayner, K. (1998) Eye movements in reading and information processing: 20 years of research. Psychological Bulletin, 124, 372-422. - Riggs LA, Armington JC & Ratliff F. (1954) Motions of the retinal image during fixation. JOSA 44, 315-321. - Riggs, L. A. & Niehl, E. W. (1960). Eye movements recorded during convergence and divergence. J Opt Soc Am 50:913-920. - Robinson, D. A. A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans. Biomed. Eng., vol. BME-l0, pp. 137-145, 1963 - Yarbus, A. L. Eye Movements and Vision. Plenum. New York. 1967 (Originally published in Russian 1962) Commercial eye trackingEdit - Chandon, Pierre, J. Wesley Hutchinson, and Scott H. Young (2001), Measuring Value of Point-of-Purchase Marketing with Commercial Eye-Tracking Data. - Duchowski, A. T., (2002) A Breadth-First Survey of Eye Tracking Applications, 'Behavior Research Methods, Instruments, & Computers (BRMIC),' 34(4), November 2002, pp.455-470. - National Highway Traffic Safety Administration. (n.d.) Retrieved July 9th, 2006, from - Weatherhead, James. (2005) Eye on the Future, 'British Computer Society, ITNOW Future of Computing,' 47 (6), pp. 32-33 - Wittenstein, Jerran. (2006). EyeTracking sees gold in its technology. [Electronic Version]. San Diego Source, The Daily Transcript, April, 3rd, 2006.
http://psychology.wikia.com/wiki/Eye_tracking
Term Paper Writing: An Introduction A term paper is an exploration paper or a research paper that needs to be written at the end of the school semester. It is needed to track the knowledge of the students at the end of the course. The term paper writing is a scientific discussion or report on the assigned topic to the students. It requires much research and writing expertise too. Moreover, these term papers must be well-written, organized, follow the analytical approach, and must be well-researched to reflect the student’s knowledge they have gained in the course. If you are writing a term paper for the first time, you need to follow a proper format and rules. Let’s take a sneak peek into them. Some Important Rules - Carefully Analyze the Topic: It is important to be creative with the given topic. If the topic is of your choice and not provided by the guide or teacher, it becomes easy to research, analyze, and write the topic. It is great to narrow down the topic to work on the key points and complete it within the prescribed time. - Well-Researched Topic: If you are taking term paper writing help, the writer must write a well-researched article. The writer must understand the background of the topic to write an informative topic. The scientific journals, interviews, expert reports, etc., must be referred. - Make an Outline of the Term Paper: The term paper outline and format must be fully understood before writing it. This will ease out the process of writing and can be deposited well in time. - Provide Proper Explanation: After deciding on the topic, researching for it, and preparing an outline, now is the time to explain your topic analytically and with proper supportive comments. Do not make the topic too complex. - Provide Proper Conclusion: After the term paper writing is over, it is important to give a proper conclusion. Emphasize the significant points so that the arguments or favors made in the term paper are fully backed up. If you are looking forward to the best term paper writing service, you can refer to these term paper writing service providers like GradeMiners, EssayPro.com, and EduBirdie. Detailed Comparison of Top 3 Term Paper Writing Service Providers With numerous term paper writing service providers present online, it becomes difficult to select the right service provider. This is where the online term paper writing service review helps the students choose the right writing providers or writers. Online platforms like EssaysOnline provide a trustworthy and reliable review of the term writing services that help save you from any hassles. We will be reviewing the top three term writing platforms today are GradeMiners, EssayPro.com, and EduBirdie. Edubirdie Review It is the best-rated writing service provider, providing versatile term paper writing, research paper writing, essays, dissertation, case study, etc. EduBirdie is offering its services since 2015. For taking the term paper writing help, you can chat with the experts and choose your writer according to the customer reviews, ranking, finished papers, and success rate. You can get the custom term paper written from EduBirdie after providing a complete set of requirements to the writers. The platform also provides a few free unique features. Moreover, the order will only get closed after you are satisfied and the term paper is provided timely. The platform experts are known for their unique and plagiarism-free writing skills. To place an order with EduBirdie: - Fill your order form and mention the subject, pages, and deadline. Do provide any add-ons too. - Scroll from various offers provided by the term paper writers. You can check their experience and other stats to make your choice. - After this, confirm your deposit. This is about to make sure that you will be paying for your order. However, your deposit will not be touched until you are satisfied with the result. - You can ask for free revisions, and when you are satisfied, only then will your money be released. Essaypro This is an online academic writing platform that connects solid and experienced term paper writers and college students. The writers are selected through a strict process to maintain the quality of term papers. When the EssayPro.com experts are satisfied with the writers’ professionalism, accuracy, speed, and knowledge, they are welcomed onboard. They offer a cheap term paper writing service that is quite accurate and professional. The term paper writing service provided by EssayPro.com includes writing the paper from scratch, rewriting of paper if you want to make it worthy of top marks, editing to make last-minute changes, and proofreading to make sure that the paper looks top-notch and presentable. The platform is known for its decent papers and punctuality as its writers have never missed any deadline. Still compared to EduBirdie they come in a strong second place. To place an order with EssayPro.com: - Provide the requisite details and instructions. Click on ‘place an order’ after you are finished with instructions and any file uploads. - Choose a suitable writer by going through the reviews and ratings. - Release the payment after you get your complete term paper. Grademiners This provider offers writing services for the last 10 years and claims that they have delivered over 97% of all the orders timely. GradeMiners was founded in 2009 in the US to help the international and local students under pressure while writing research or academic papers. Moreover, the writers onboard are pre-screened and must possess at least 1 year of experience to work with GradeMiners. The platform states that it can provide the term paper writing service in just 10 days. Their term papers are known for engaging the readers and send a crisp and clear message. In addition, full confidentiality is provided to the students as term paper looks as if you have written on your own. Strict quality control and plagiarism checking are two top-notch service features. However, this platform has earned a notorious reputation due to severe issues concerning the quality of their work, money back policy and bad customer reviews. Compared to the other two platforms they offer the worst service. If you still want to place an order with GradeMiners do so on your own risk and follow these steps: - State the instructions carefully in the online form. If there are any extra details you want to provide, do mention them. - Choose from the writers’ given options like best available, top writer, or the premium writer. - Free revisions will be provided, and a refund will be given within 14-30 days if the result did not match your expectations. Comparative Difference between EduBirdie, EssayPro.com, and GradeMiners | | Basis of Comparison | | EduBirdie | | EssayPro.com | | GradeMiners | | Pricing Plan | | $13.99 per page. The writers provide free revisions until completely satisfied. | | $7 per page. If the deadline goes long, you can avail of a discount of 40% on the writing services. | | $13.28 per page. For higher academic level term papers, it can rise to $50 per page. | | Payment Options | | Visa Card, Discover, MasterCard, and American Express. | | MasterCard, Visa Card, PayPal, and American Express. | | Discover, American Express, Visa Card, and MasterCard. | | Guarantees Provided | || || | | | Pros | || || | | | Cons | || || | Comparative Order for EduBirdie, EssayPro.com, and GradeMiners Despite some of the disadvantages that every term paper writing service has, there are many great features. The comparative order goes like EduBirdie offers the best term paper writing service out of the three providers. GradeMiners offers a mid-level service, but its guarantees are quite good. Coming on to EssayPro.com, it has earned a bad market reputation because of its rigid money-back policy and customer issues. Final Comments If you are looking for quality high school and college term papers, then EduBirdie is the most trustworthy platform. However, if you are looking for mid-income sites where you can also put in little extra effort to make your term paper personalized, EssayPro.com and GradeMiners are still a good option. Overall, all three online term paper writing service providers are legit.
https://essaysonline.org/best-term-paper-writing-service/
Arka received his PhD in Physics at the University of Illinois, Urbana-Champaign (UIUC) in 2017. He was a KIPAC fellow (2017-2020) at the Kavli Institute for Particle Astrophysics and Cosmology (KIPAC) at Stanford University and SLAC. From 2020 to 2022, he was a Schramm Fellow in Theoretical Astrophysics at Fermilab (USA), before joining IISER Pune. The evolution and clustering of inhomogeneities in our Universe is sensitive to the properties of various components that make up our Universe, including Dark Energy, Dark Matter, and neutrinos. Understanding this process in detail can help pin down the nature of Dark Energy and Dark Matter, and the total mass of the Standard Model neutrinos - some of the biggest open questions in physics. We work on the theoretical and modeling aspects of this program, making use of complex numerical simulations, and novel statistical techniques.
https://www.iiserpune.ac.in/research/department/physics/people/faculty/regular-faculty/arka-banerjee/381
Mealtimes are fundamental daily pit stops that drive a child’s growth journey. They also create bonding moments for parents and their little ones. However, many parents face mealtime stress with the top concerns being the time taken for their child to finish a meal, whether their child is getting a balanced diet for growth and when the child is not eating properly during mealtime. We speak to Dr Michelle Tan, paediatrician and consultant in the division of paediatric gastroenterology, nutrition and hepatology, National University Hospital (NUH), Singapore about childhood nutrition and feeding-related issues in children. 1. My child is not finishing any of the meals that I’ve prepared. How can I ensure that my child is still getting all the important nutrients? Aim to still give a well-balanced diet with foods from each food group at each meal so as to maximise the consumption of as much nutrition as possible. Providing a variety of foods from each food group allows your child to obtain different key nutrients and keeps meals interesting. Other than main meals, snack options can also be nutritious. Try to avoid snacks that contain calories mainly from sugar or fat with little dietary fibre, protein, vitamins or minerals. Consumption of these snacks may result in an unbalanced intake of energy vs. essential nutrients, leading to deposition of fat tissues. Hence, a healthy and balanced diet should be nutrient-dense over energy dense so that children can get the key nutrients – protein, vitamins and minerals that are essential for growth. Some healthy snacks that parents can provide their children include bananas, dry fruits, and whole-grain cereal. Moreover, nutritional supplements can also be considered on a case-by-case basis to ensure the child meets daily nutritional needs and maximise growth potential. 2. When should I be worried that my child is not eating well? What can I do during such periods of ‘food strikes’? Poor or inadequate nutrition can affect immunity, causing children with nutritional deficiencies to fall sick more often. When children fall sick, nutrient resources get diverted to fight infection and support recovery and therefore fewer nutrients are available for growth. Moreover, sick children usually have a poor appetite which makes nutrient intake even lower. Therefore, children who fall sick often are particularly at high risk of malnutrition. There are recommended solutions that all parents can follow during mealtimes to encourage their child to finish the meal such as: - Instead of serving just 3 big meals a day, it is useful to encourage appetite by serving small meals and snacks at consistent times of the day, with 2–3 hours between each meal and snack time, allowing the child to become hungry before the next meal. - Avoid distraction by seating children at a table for meals and snacks, minimising the use of electronic devices at mealtimes, as this takes away the interaction during meal times. - Systematically introduce new food – provide some of the child’s favourite foods together with a small amount of new food. If the child refuses a new food, offer just one bite of the new food without bribing or forcing. - Parents should be good role models. Families should eat together to allow interaction and bonding and parents themselves should eat the foods that they are encouraging their children to eat. - If your child’s poor eating habits persist, you are encouraged to consult their doctor or dietician to get more detailed advice. 3. My child dislikes trying new food or food with unfamiliar textures. How can I help to expose my child to different kinds of food? You can involve your child in the mealtime process to increase their interest in new food and variety. You can take them grocery shopping to get them familiarised with the different foods. By making it an adventure when familiarising them with the different food items, they may have a different outlook on certain foods they used to shy away from due to unfamiliarity. In terms of accepting textures, you may have to gradually increase the texture of the foods over time and different occasions so that your child can eventually accept food that is of a more challenging texture. 4. Is it necessary to include nutritional supplements apart from my child’s daily meals during this critical period of growth? To maximise the natural growth potential and nourish your child optimally, supplements can be useful in supporting the critical growth period when their food intake is incomplete and when they are unable to consume adequate calories and nutrition from their meals. ⇒ Related Read: Power Up! Top 10 Immunity Foods For Children 5. What are some family mealtime rules that should be set? Distractions should be removed by turning off screens and devices during mealtimes to focus on building conversations during mealtimes. By taking the focus away from their screens or devices, it would better support family bonding time. It would also be beneficial for the family if a mealtime routine was established. Mealtimes that stretch over 30 minutes should be respectfully ended so that both parent and child can get the much-needed relief. Additionally, when a child is familiar with a mealtime routine, it becomes a calmer experience for everyone involved. 6. What should a balanced meal for young children consist of? The general feeding guideline for young children is: – For children aged 1-2 years: - 2-3 servings of brown rice and wholemeal bread - Half to 1 serving of fruit - Half a serving of vegetables - Half a serving of meat and others - One and a half serving of dairy foods or calcium-containing foods – For children aged 3-6 years: - 3-4 servings of brown rice and wholemeal bread - 1 serving of fruit - 1 serving of vegetables - 1 serving of meat and others - 1 serving of dairy foods or calcium-containing foods You can refer to this link for more details. Want to be featured here? Leave your contact here and we’ll be in touch. Stay in touch! Subscribe to our Telegram here for all our latest updates.
https://thenewageparents.com/feeding-problems-in-children/
This activity for the London Festival of Architecture is about the potential and power of Norwood High Street as a symbol for many similar London high streets currently in crisis. We believe Norwood High Street and its surrounds can be re-invented as a creative and cultural link between Brixton and Croydon. There are key sites available for affordable housing and developer-led projects, but we want to ensure the street level remains in use by and for the local people. This means affordable workspace, parks, pop-up venues, ecology walks, cafés, innovation hubs. We need to ensure the local makers, artists, school-children, freelancers, young families, SMEs and senior citizens have a high street that serves their needs. Working with the local community and in collaboration with Station to Station, the Business Improvement District for Tulse Hill and West Norwood, A Small Studio proposes a radical re-think of the use of this high street. Public consultation The British high street has been in gradual decline for the past 20 years. The number of empty shops in 2020 is at a record high of 12% nationally. However, the COVID-19 lockdown might lead to a re-emergence of the high street because during lockdown, residents have turned to their corner shops for their convenience and proximity to home. We think there is untapped potential in Norwood High Street, which is currently an area with limited commerce but with a wealth of industry, artists and makers working around its edges. The Power of Norwood High Street Working with the local community and in collaboration with Station to Station, the Business Improvement District for Tulse Hill and West Norwood, A Small Studio proposes a radical re-think of the use of this high street, as a month-long digital consultation on The Power of Norwood High Street. Through a series of online talks and web-based interactive workshops, we will work with different local demographics to get a wider (and more exciting!) series of proposals to revitalise and redefine the role of Norwood High Street. We will concentrate on: the existing high street buildings (currently mainly commercial); a future high street square; and the mixed-use fringe (mainly artists & makers workspaces). The programme culminates in an online exhibition to showcase the community results. These results will also inform the ongoing Neighbourhood Plan that is currently being written by a cohesive committee made up of local community representatives, residents and a number of built environment professionals including A Small Studio and Station to Station (BID). Citizen-led approach This project is about understanding the untapped power that Norwood High Street has and promoting a citizen-led approach for its regeneration. Using the Mayor of London ‘High Streets For All’ recommendations for and inclusive, shared and locally-responsive growth on the high street, all activities share a common ethos: Take a strategic place-based approach; Promote citizen-led regeneration; Be inclusive by engaging harder-to-reach citizens; Protect diversity and choice; Recognise the social value of high street economies; Value the contribution of high street businesses; Champion high streets as social, civic and cultural infrastructure; Value high streets as sources of civic pride and local identity; Champion high streets as public spaces; Uphold an evidence-based approach. Who is A Small Studio A Small Studio is a design studio based in London and work in architecture, interior design, landscape, planning and research. Being small means that we are flexible. Although we are chartered architects and professional researchers, we use the studio as a platform to work with other professionals. We frequently collaborate with makers, builders, artists, landscape architects, filmmakers and writers. Who is Station to Station The BID is actively involved in this collaboration as A Small Studio’s aims are ours – to push Norwood High Street to reach its full potential as a dynamic, affordable workspacing hub for all of Lambeth. Our aspiration, and Lambeth Council’s, is to see this underused and unloved street bought back to life; full of workers from start up companies and creative industries, sharing workspaces with artists, makers and designers. In a post Covid 19 world, we would like those small businesses that have struggled to cover costs to make this area their new base for flexible and affordable workspace. Events for booking We will present: What is the project; Why we are interested; Who is it for?; When are the activities?; How will we share information and reach a wider audience? Who we are? To attend the Presentation on the 1st June just sign up here This activity is for children to get involved in reimagining West Norwood High Street. This will be via Feast, the West Norwood monthly community event organised by local volunteers, as part of their children’s activities. The purpose of this activity is to engage young school children in drawing and model-making to explore and share their ideas for what type of street frontages shops could have and what type of activities they would dream of having in their local High Street. They can share photos of their creations at [email protected] and this will be part of our Zoom Exhibition on the 26th June. Find out how to be part of the Activity for Children via Feast on the 7th June on West Norwood Feast This Pecha-Kucha is open to all via Zoom. There will be six presentations from invited architects, artists and planners who work locally. Each will present a utopian vision of how Norwood High Street could be regenerated. To attend the online Pecha Kucha on the 17th June just sign up here To give some ‘food for thought’, the focus of this webinar ‘High Streets, lowlands by Ed Wall’ is to show how landscape tactics can be applied in an urban context. To attend the Landscape Webinar on the 19th June just sign up here. This is an informal open discussion to learn how Croydon developed a program of ‘meanwhile strategies’ for converting their empty shops into useful spaces. Members of the Regeneration Team together with local artists, business and makers will discuss the benefits from flexible light-industrial workspaces. To attend the Open Discussion on the 25th June just sign up here The purpose of this is to hold a closing event where all the information collated throughout the month-long consultation can be viewed and comments made. Due to the COVID-19 lockdown, the closing event will be turned into a virtual exhibition on the website To attend the Exhibition on the 26th June just sign up here. Contributors to The Power of Norwood High Street West Norwood Feast: children’s workshops in the West Norwood monthly community event organised by local volunteers L’Arche: organization building community with people with learning disabilities The Elmgreen School: secondary school Local residents Norwood High Street Landowners Portico Gallery Small Medium Enterprises (SME) Shopkeepers of Norwood High Streeet FFLO: landscape studio Harry Bix: Artist, Landscape Architect Tutor, Designer, Musician Mark Fairhurst Architects: architecture studio One Hundred Projects: Ed Wall, Academic Leader Lanscape at the University of Greenwich Prior & Partners: urban planning and design firm R2 Studio Architects: architecture studio Untitled Practice: landscape and architecture design office Lambeth Councillors London Borough of Lambeth: Business, Culture and Investment Team London Borough of Lambeth: Planning Team London Borough of Lambeth: Policy Team London Borough of Lambeth: Regeneration Team How will we use the results? The project ‘The Power of Norwood High Street’ will be used to inform the Neighbourhood Plan. The Norwood Planning Assembly (NPA) is currently writing The Norwood Green Town Plan which is the Neighbourhood Plan for Norwood. This is being written by a cohesive committee made up of local community representatives, residents and including a number of built environment professionals. The Norwood Green Town Plan sets out a shared vision and ambitions for our neighbourhood over the next 10-20 years. Why prepare a neighbourhood plan? As a community we worry about the cost of living, job security, access to shops, facilities and green space and the impact of air pollution. We worry about what kind of place Norwood will be for our children. We also worry about the nature and impact of new development that takes place within our community. The Plan will set out our ideas for addressing these and other issues to ensure Norwood remains a great place to live, with a prosperous and resilient future. In particular we want to make sure that Norwood does all its can to respond to the global impacts of climate change and the climate emergency that has been declared by organisations worldwide, including the UK Parliament and Lambeth Council. Our vision and policies will be defined to ensure that environmental issues are considered in every aspect of planning, development and regeneration. What is a neighbourhood plan? The government’s Localism Act 2011 is intended to give local communities a greater say in planning issues, and to let local people decide upon a vision for their area. Under the Act, towns and parishes can prepare Neighbourhood Plans, which will form part of a district plan. Neighbourhood Plans can cover not only development, but infrastructure needs, like schools, roads, medical provision, water, electricity, gas, waste water disposal, broadband, and economic and social objectives. The Green Town Plan is our neighbourhood plan for Norwood which, once adopted, will help shape the future development of the area. The Plan is being prepared by the Norwood Planning Assembly in collaboration with local community organisations: Norwood Action Group; Norwood Forum; and Station to Station BID.
http://asmallstudio.co.uk/project/the-power-of-norwood-high-street/
Our private sector and market development work aims to increase investment in sectors - such as smallholder agriculture - that enable economic growth to be more equally distributed and, where necessary, challenge power imbalances. Business has great potential for alleviating poverty. We want to maximise the contribution that business can make towards poverty reduction by challenging some practices and building a model for ethical trade. This is another route for developing sustainable livelihoods for people living in poverty around the world. Our work in this area has two main approaches: working with the private sector and developing fairer, more accessible markets. Influencing the debate on the role of the private sector in poverty alleviation: through campaigning and programme delivery we aim to change beliefs, attitudes, policies and practices at both global and local levels on issues around poverty alleviation, among governments, International Financial Institutions, companies, civil society, and consumers. we focus on changing policies, practices, and core business operations in three key global sectors to maximise poverty reduction: finance, agriculture, and climate change. Changes to business practice: Oxfam is a co-founder of the Ethical Trading Initiative (a three-way alliance between NGOs, trade unions, and companies including Gap Inc, Next, Marks & Spencer, Tesco, and Asda), as well as of Fairtrade Foundation and Cafédirect. We work with businesses, encouraging them to deliver social and ethical value for poor people and their communities through their skills, competencies and innovation, and changes to business practice in ways that bring lasting and sustainable change. To support this work we have developed a range of Briefings for Business. Local private sector development: we facilitate the development of an equitable local private sector that employs or trades with remote rural and marginalised urban women and men living in poverty. Inclusive, sustainable, and fair market development requires a responsive private sector and an effective national and local government. Smallholders in supply chains: we aim to enable women and other marginalised smallholders to gain higher returns from products traded primarily with domestic companies. This includes facilitating innovative financial and agricultural services; working with domestic companies to adapt their business models to be inclusive and fair; and increasing the producer's voice in governance systems. See more on our work with Smallholder Supply Chains. Feeding the cities: facilitating improved access and linkages for remote rural producers to urban markets and increasing the food security of urban consumers. Producer organisation and enterprise development: this is achieved by creating enterprises or producer organisations that increase producers' power to enter markets, negotiate terms within markets, capture decent benefits from markets and influence the rules that govern markets. See more on our Enterprise Development Programme. Facilitating urban local economic development: a new area with experimental work around urban enterprise development and developing key sectors for those living in poverty. Oxfam works with companies to help them understand how their operations affect the people in their value chains and the communities and countries in which they operate which in turn plays a role in determining the success of the business itself. Oxfam's joint initiative with the investment industry, the Better Returns in a Better World project assesses the potential for investors to contribute to poverty alleviation through their investment activities. We also ask companies to help reduce the impact of climate change by setting targets for emissions reductions and keeping to them. Investing in small rural enterprises in places that financial institutions do not reach. Oxfam's cutting edge gendered market system approach to sustainable livelihoods development. Improving livelihoods for small scale producers in South-East Asia through responsible, gender transformative value chains and private sector investments. Influencing and enabling companies to respect labour rights in global supply chains. A living wage is a human right - keeping people out of poverty, affording a basic lifestyle and allowing them to them to participate in social and cultural life.
https://policy-practice.oxfam.org.uk/our-approach/private-sector
'Hidden Bias of Good People' helps us recognize our implicit biases WPTV is continuing our conversations about equity, diversity, and inclusion with a one-hour, commercial-free broadcast special on March 11 at 9 p.m. The special, "Hidden Bias of Good People," looks at how the individuals and ideas we've been exposed to throughout our lives take hold, and while we assume we're always thinking independently, we're not. It's called implicit bias. So how can we be more aware of our bias and be more compassionate parents, friends, neighbors, and coworkers? Dr. Bryant T. Marks Sr., a minister, researcher, trainer, and award-winning educator, will host the hour-long special and provide answers. When you hear the word bias, you may immediately think it's a bad thing. But that's not necessarily the case. Your biases may make you act more positively toward a group due to your own life experiences. It can also cause you to act negatively toward others without knowing it. In fact, you almost certainly have some implicit biases (often called unconscious biases) towards different social attitudes. So, how do you counter implicit bias? The first step is to know your biases. From there, it requires conscious efforts. The Tory Burch Foundation lists these steps you can take: Identify your biases Be mindful of what you say and how you say it Question your thinking and challenge your assumptions Seek diversity in your friendships and interactions Hold yourself and others accountable when unconscious bias surfaces Avoid generalizations, and catch yourself when you use them and ask yourself if the statement was true Imagine positive images of a group you tend to be biased about Listen to someone else's story and exercise empathy Raise your children to embrace diversity and equality Dr. Marks is the founding director of the National Training Institute on Race and Equity and is a professor in the Department of Psychology at Morehouse College. He served on President Barack Obama’s Board of Advisors with the White House Initiative on Educational Excellence for African Americans. Following the "Hidden Bias of Good People" special, WPTV anchors Kelley Dunn and Tania Rogers will host a virtual roundtable at 10 p.m. on the WPTV Facebook page with members of our local community to get their insight into how people can overcome their implicit biases. Joining Dunn and Rogers will be Patrick Franklin from the Urban League of Palm Beach County, Maha ELKolalli from the South Florida Muslim Federation, Maricela Torres from the Esperanza Community Center, and Josephine Gon from the Jewish Federation of Palm Beach County.
Cysteine rich with EGF-like domains 2 (Creld2) is a novel endoplasmic reticulum (ER) resident molecular chaperone that has been recently implicated in the ER stress signalling response (ERSS) and the unfolded protein response (UPR). Global transcriptomic data derived from in vivo mouse models of rare chondrodysplasias; Multiple Epiphyseal Dysplasia (MED Matn3 p.V194D) and Metaphyseal chondrodysplasia type Schmid (MCDS Col10a1 p.N617K), identified a significant upregulation in Creld2 expression in mutant chondrocytes. These chondrodysplasias share a common disease signature consisting of aberrant folding of a matrix component often as a result of inappropriate alignment of intramolecular disulphide bonds. This in turn culminates in toxic protein aggregation, intracellular retention mutant polypeptides and a classical ER stress response. The aim of this study was to further analyse the function of Creld2 in cartilage development and chondrodysplasias in which endochondral bone growth is perturbed. Protein disulphide isomerases (PDIAs) were amongst the most up-regulated genes in the MED and MCDS mouse models, consistent with the prolonged exposure of normally 'buried' cysteine residues. This led to the hypothesis that Creld2 was functioning as a novel PDI-like oxidoreductase to assist in the correct folding and maturation of aggregated misfolded polypeptide chains through REDOX regulated thiol disulphide exchange. A series of Creld2-CXXA substrate trapping mutants were generated in order to determine whether Creld2 possessed inherent isomerase activity. Here potential substrates interacting with Creld2 were 'trapped' as mixed disulphide intermediates, then isolated by immunoprecipitation and identified by mass spectrometry analysis. It was demonstrated that Creld2 possessed a catalytic active CXXC motif in its N-terminus that enabled the molecular chaperone to participate in REDOX regulated thiol disulphide exchange with at least 20 potential substrates including; laminin (alpha3,β3,γ2), thrombospondin 1, integrin alpha3 and type VI collagen. There was also numerous co-chaperones and foldases thought to be part of a specialised protein-protein interactome (PPI) for folding nascent polypeptides translocating the ER lumen. Moreover, co-immunoprecipitation experiments supported a protein-protein interaction between Creld2 and mutant matrilin-3, thereby inferring a potential chondro-protective role in resolving non-native disulphide bonded aggregates in MED. An established biochemical approach was employed to test the hypothesis that all MATN3-MED disease causing mutations have a generic cellular response to the β-sheet V194D mutation, consisting of intracellular retention, protein aggregation and ER stress induction. Several missense mutations were selected for analyses which encompassed a spectrum of disease severity and included examples of both β-sheet and alpha helical mutations. It was possible to define a reliable and reproducible assay for categorising MATN3 missense mutations into pathological or benign based on these basic parameters. This study was extended further to determine whether there were common pathological mechanisms behind MED and Bethlem myopathy (BM) caused by missense mutations in von Willebrand Factor A domain (vWF-A) containing proteins (matrilin-3 and type VI collagen respectively). We chose to compare and contrast the effects of an archetypal MATN3-MED causing mutation (R121W) with the equivalent COL6A2-BM causing mutation (R876H). These mutations compromised protein folding and maturation, resulting in the familiar disease profile of intracellular retention, protein aggregation and an ER stress response in an artificial overexpression system. However, the mutant C2 domain was efficiently targeted for degradation whilst mutant matrilin-3 vWF-A domain appeared to be resistant to these molecular processes.Molecular genetics was employed to study the role of Creld2 in vivo. Creld2-/- null mice (both global and conditional) were generated to directly examine the role of Creld2 in endochondral bone growth. Global knock-out mice were viable with no overt phenotype at birth. However, female Creld2-/- null mice showed a significant reduction in body weight and tibia bone length at 3 weeks of age. A cartilage specific knock-out was generated to determine whether these skeletal abnormalities were attributed to a systemic or a direct effect on cartilage development. [Creld2Flox/Flox Col2Cre (+)] demonstrated a severe chondrodysplasia with significantly reduced body weight and long bone growth compared to control littermates. Morphological and histochemical analysis of mutant growth plates revealed gross disorganisation of the chondrocyte columns with extensive regions of hypocellularity. These pathological features were confirmed to be the result of reduced chondrocyte proliferation and increased/spatially dysregulated apoptosis throughout all zones of differentiation. Taken together, these data provide evidence that Creld2 possesses isomerase activity and exhibits distinct substrate specificity. Furthermore, Creld2 has a fundamental role in post-natal cartilage development and chondrocyte differentiation in the growth plate.
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756800
What is a clinical trial? The World Health Organisation's (WHO) definition for a clinical trial is 'any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes'. Clinical trial interventions include, but are not restricted to: - Experimental drugs - Medical devices - Surgical and other medical treatments and procedures - Psychotherapeutic and behavioural therapies - Health service changes Researchers may also conduct clinical trials to evaluate diagnostic or screening tests and new ways to detect and treat disease. Clinical trials and the Therapeutic Goods Administration Clinical trials are needed to collect data required by the Therapeutic Goods Administration (TGA), part of the Australian Government Department of Health and Ageing that is responsible for ensuring that healthcare products available in Australia are safe and effective. Therapeutic goods must be entered into the Australian Register of Therapeutic Goods (ARTG) before they can be lawfully supplied in or exported from Australia, unless they are exempt or otherwise authorised by the TGA. The TGA enter therapeutic goods into the ARTG when: - Higher risk therapeutic goods have been assessed as meeting the requirements for quality, safety, and where appropriate, efficacy and/or performance; or - Lower risk medicine, biological or medical device applications have been validated Goods which have not been evaluated by the TGA for quality, safety and efficacy, and entered into the ARTG for general marketing, are referred to as 'unapproved goods', because such products are considered experimental, and do not have general marketing approval. These include: - Any product not entered into the ARTG; or - Use of a registered or listed product in a clinical trial beyond the conditions of its marketing approval There are several schemes under which 'unapproved goods' may be lawfully supplied. Ethical Review and Research Governance Procedure for all Early Phase Clinical Trials at Barwon Health To adopt current best practice in Victoria, and as a complement to current standard ethical review and research governance, the following document outlines a procedure for all Early Phase Clinical Trials (Phase 1) at Barwon Health. Important Update from the TGA A new online form is now available for the Clinical Trial Notification (CTN) Scheme. As of the 1st of July 2016, the TGA will no longer accept paper versions of the CTN forms. All applications to the TGA must now be submitted electronically. Guidance material for the new online CTN form is available on the TGA website. This is a welcome initiative and will enhance the efficiency of governance aspects of clinical trials in Australia. Please click here for further information. For Sponsors submitting eCTNs for clinical trials being conducted at Barwon Health, the approving authority information is provided below: Name of Approving Authority: Barwon Health, University Hospital Geelong Barwon Health HREC Code: EC00208 Approving Authority Contact Officer: Ms Lisa Fry Position: Research Governance Officer Contact Phone: (03) 4215 3373 Contact Email: [email protected] For projects approved by the Barwon Health HREC, the HREC contact information is provided below: HREC Name: Barwon Health Human Research Ethics Committee Barwon Health HREC Code: EC00208 HREC Contact Officer: Mr Richard Larsen Position: Research Ethics Officer Contact Phone: (03) 4215 3371 Contact Email: [email protected] Please email [email protected] to provide any feedback which will help to continually improve this new format. The Clinical Trial Notification (CTN) Scheme is a notification scheme, and over 95% of all trials are approved via this route. Where a HREC bears the responsibility for approving: - The safety and efficacy of the medicine or device - The ethical acceptability of the trial process - Approval of the trial protocol - Evaluating the scientific merit of the trial The CTN is required when a clinical trial investigates the use of a product in Australia which is either: - Not on the Australian Register of Therapeutic Goods (ARTG) - On the ARTG, but being used outside the conditions of its marketing approval The TGA does not review any data relating to the clinical trial, but acknowledges the trial in writing within ten days of receipt of the signed CTN form and appropriate payment. A separate CTN form must be completed for each potential trial site. It is standard for all fees to be reimbursed to the CRO by the Sponsor as part of the trial budget. CTN trials cannot commence until the TGA has been notified of the trial, and the appropriate notification fee has been paid. The Clinical Trial Exemption (CTX) Scheme is rarely used in Australia but is a modified approval process by which a Sponsor submits an application to conduct a clinical trial to the TGA for evaluation and comment. A TGA delegate then decides whether or not to object to the proposed usage guidelines for the product. A Sponsor cannot commence a CTX trial until written advice has been received from the TGA regarding the application and approval for the conduct of the trial has been obtained from a HREC at each institution where the trial will be conducted. Clinical trials in which registered or listed medicines or medical devices are used within the conditions of their marketing approval are not subject to CTN or CTX requirements, but still need to be approved by a HREC before the trial may commence. Clinical trial Sponsors The Sponsor is the individual, company, organisation, or institution that: - Intends to supply the goods - Initiates, organises and supports a clinical study - Takes overall responsibility for the conduct of the trial - Signs either the CTN or CTX form - Is responsible for meeting the regulatory requirements of the Therapeutic Goods Legislation All CTN and CTX trials must have an Australian Sponsor. For more information about the Sponsor's responsibilities, please see the Australian Clinical Trial Handbook. Clinical trials can be divided into two groups, according to the type of Sponsor: - The typical industry-sponsored clinical trial, where the trial is conducted by a private entity (who is commonly the holder of the 'marketing approval' of the trial product) - The investigator initiated trial where the Sponsor is not a commercial entity, but an individual health professional or a 'not-for-profit organisation', which can be a governmental body (e.g. a public institution hospital, University, a trust, or a research group) - also called a NCT (non-commercial trial) The responsibilities of a trial Sponsor, with respect to Good Clinical Practice (GCP), are extensive and are detailed in Item 5 of the Note for Guidance on GCP. Good Clinical Practice (GCP) All clinical trial research conducted under the auspices of Barwon Health and all research conducted in Australia, must comply with the Australian adopted version of ICH-GCP Guidelines. The Note for Guidance on GCP (CPMP/ICH/135/95) is an internationally accepted standard for the designing, conducting, recording, and reporting of clinical trials. The TGA has adopted CPMP/ICH/135/95 in principle, but has recognised that some elements are, by necessity, overriden by the National Statement (and therefore not adopted) and that others require explanation in terms of 'local regulatory requirements'. Failure to conduct research in line with GCP guidelines contravenes the Australian regulatory framework and increases exposure to risk. GCP Training Barwon Health requires investigators on clinical trials to hold current GCP Certification which meets the minimum criteria required, and appears on the recognised list of courses and training providers on the TransCelerate Biopharma Inc website. The REGI Unit recommends GCP training courses offered by ARCS Australia. TGA Fees TGA fees for the CTN scheme are currently AUD$320.00 for each notification. A notification can be made for all sites participating in the trial simultaneously, or several notifications can be made for sub-groups of sites. A notification fee applies for each single notification. The fee for a CTX 50 day review is AUD$19,400.00 (review of chemical, pharmaceutical and biological, pharmaco-toxicological and clinical data). The fee for a 30 day review is AUD$1,560.00. Additional schemes There are also a number of ways that patients can gain access to products that have not been approved for use in Australia: - Authorised Prescribers - the TGA is able to grant medical practitioners authority to prescribe a specified unapproved therapeutic good or class of unapproved therapeutic goods to specified recipients or classes of recipients - Special Access Scheme - the Special Access Scheme refers to arrangements which provide for the import and/or supply of an unapproved therapeutic good for a single patient, on a case by case basis How to prepare a clinical trial application For all clinical trials, please submit the following to the REGI Unit, as applicable: - A copy of the Investigator's Brochure - Evidence of GCP Training by Principal Investigator - A CTN or CTX form - Three original copies of the applicable Clinical Trial Research Agreement (CTRA) signed by the Sponsor and Principal Investigator (for drug trials only) - Three original copies of the MTTA Standard Clinical Investigation Research Agreement (CIRA) signed by the Sponsor and Principal Investigator (for device trials only) - Insurance certificate (for commercially sponsored clinical trials only - this should comply with the requirements for clinical trial's insurance as outlined in the VMIA Guidelines for Clinical Trials for Victorian Public Hospitals) - Two original copies of each the Standard Medicines Australia Form of Indemnity for Clinical Trials and HREC Review Only Medicines Australia Form of Indemnity for Clinical Trials (for commercially sponsored drug trials only) - Two copies of each the Standard Medical Technology Association of Australia Form of Indemnity for Clinical Investigation and HREC Review Only Medical Technology Association of Australia Form of Indemnity for Clinical Investigation (for commercially sponsored device trials only) Please note: For all CTRAs and CIRAs to which Barwon Health is a party, complete the 'Institution' details on Page 1 as follows: Name: Barwon Health Address: Ryrie Street, Geelong VIC 3220 ABN: 45 877 249 165 Contact for Notices: Director of Research Phone Number: (03) 4215 2032 Please note: For all indemnities given by Sponsors to Barwon Health, please complete the 'To' or 'the Indemnified Party' section on Page 1 as follows: Name: Barwon Health ABN: 45 877 249 165 Address: Ryrie Street, Geelong VIC 3220 The Sponsor or Barwon Health Principal Investigator (for Barwon Health investigator initiated projects) sends the completed CTN to the TGA. CTN Acknowledgement should be sent to RGO once received by emailing [email protected]. Clinical trial governance submission Prior to submitting your application, a Barwon Health Reference Number is required - please refer to the How to prepare an application webpage for instructions on how to obtain a reference number. In addition: - Please refer to the Multi-site applications webpage for instructions on what is required for a governance application for a multi-site clinical trial - Submit the complete electronic version (including the CTN, agreement, indemnity, insurance certificate, etc.) of your research governance/site specific assessment application by emailing [email protected] - Submit the signed hardcopy agreement and indemnity to the REGI Unit, Level 2 Kitchener House, University Hospital Geelong, Geelong VIC 3220 (please ensure that these hardcopy documents contain original signatures) - Research governance/site specific assessment applications can be submitted at any time - ideally, they should be submitted well before, or at the time of, the relevant ethics submission to the HREC.
http://barwonhealth.org/research/research-ethics-governance-integrity-regi-unit/clinical-trials
Description: bFM Catalog: BirdsCatalog Subset: SpecimenScientific Name: Apteryx australis mantelliPhylum: ChordataClass: AvesOrder: ApterygiformesFamily: ApterygidaeGenus: ApteryxSpecies: australisSubspecies: mantelliCollector: No Person (Birds)Geography: Oceania, New ZealandDWc Country: New ZealandPreparations: skelTissue Available?: NoCo-ordinates Available?: NoSex: FemaleEMu IRN: 877383OccurenceID: 7878b331-f623-45b8-84da-d6852358cc22Measurements: Measurement taken Value Unit skull g Weight Fat Tissue Molt Gonads Stomach Contents Iris Color Upper Mandible Color Lower Mandible Color Tarsus Color Tarsus Color Disclaimer: The Field Museum's online Zoological Collections Database may contain specimens and historical records that are culturally sensitive. Some records may also include offensive language. These records do not reflect the Field Museum’s current viewpoint but rather the social attitudes and circumstances of the time period when specimens were collected or cataloged. We welcome feedback. The web database is not a complete record of the Museum’s zoological holdings, and documentation for specimens will vary due to when and how they were collected as well as how recently they were acquired. While efforts are made to ensure the accuracy of the information available on this website, some content may contain errors. We work with communities and stakeholders around the world to interpret the collections in order to promote a greater understanding of global heritage and, through consultation, will revise or remove information that is inaccurate or inappropriate. We encourage and welcome members of communities, scholars, and others to contact us to confirm or clarify data found here.
https://collections-zoology.fieldmuseum.org/catalogue/877383
Download citation file: Close - Share - Tools Abstract The Gulf of California, or, more poetically, the Sea of Cortez, is a fascinating and complex semienclosed sea of the eastern North Pacific. Surrounded by arid and mountainous regions, the Gulf loses moisture to the atmosphere, creating a high-salinity, relatively warm water mass, and giving rise to a vertical thermohaline circulation. Although there is an excess of evaporation over precipitation in the Gulf, there is a net gain of heat from the atmosphere, of sufficient magnitude to reverse the evaporative buoyancy loss. This combination of air-sea heat and moisture fluxes requires an annual average of deep inflow and shallower outflow, which is opposite to the exchange between the Mediterranean Sea and the Atlantic Ocean or the Red Sea and the Indian Ocean. Water mass transformation in the northern Gulf reflects this inverted system: limited convection and extensive tidal mixing combine the saline surface waters of the far northern Gulf and the fresh, deep, inflowing Pacific Intermediate Water into a distinct water mass, Gulf Water, exchanged with the Pacific. Deep inflow to the Gulf provides enhanced nutrients and may well be responsible for the high productivity observed in the Gulf. Tides are strong in the Gulf because of co-oscillation with the Pacific and resonance of the semidiurnal component. Significant tidal energy also distinguishes the Gulf from other midlatitude marginal seas, providing energy for enhanced mixing. Wind forcing of circulation in the Gulf appears to be of secondary importance, even over the shelf. Remote effects, including coastally trapped waves, dominate shelf circulation on the eastern side of the Gulf, at least during summer. Although energetic currents are observed on the western boundary of the Gulf, they do not appear to correlate with the local wind nor with the shelf waves on the eastern coast. The forcing mechanisms responsible for observed basinwide gyres and intense currents along the western boundary have yet to be identified. Interannual variability in the Gulf is dominated by effects of the global phenomenon labeled El Niño-Southern Oscillation (ENSO). In the Gulf, productivity is greatly enhanced during ENSO years, unlike the open coast of California, where productivity is reduced. ENSO conditions in the eastern Pacific bring warm, fresh Tropical Surface Water well into the Gulf, where it is normally not found. Water mass formation by winter convection appears to be more widespread during ENSO years, possibly reflecting changes in the water mass flowing into the northern Gulf during ENSO winters. Changes in hydrography during ENSO years extend to the bottom of the 1500-m-deep channels of the northern Gulf and suggest annual renewal of those deep, oxygen-rich waters. Figures & Tables Contents The Gulf and Peninsular Province of the Californias The Gulf of California is an excellent laboratory for studying sedimentary processes on time scales that are not resolvable in the open ocean. The high biological productivity and the unique physical character of the gulf combine to produce sedimentological processes that preserve annual phenomena. This volume is organized into six sections. Part 1 covers historical exploration of the area. Part 2 includes 5 chapters detailing information contained on the 5 fold-out maps that accompany the volume. Part 3 consists of chapters on regional geophysics and geology. Part 4 covers satellite geodesy. Part 5's seven chapters discuss physical oceanograpy, primary productivity, and sedimentology. Part 6 covers hydrothermal processes.
https://pubs.geoscienceworld.org/books/book/1339/chapter/107171524/Physical-Oceanography-of-the-Gulf-of-California
Social networking tools have taken off in the past five years. Facebook has over 800 million users, Twitter over 200 million, and even newcomer Google+ with over 50 million. The ubiquity of these tools in our personal lives has spilled over the firewall and into the enterprise, re-labeled as social computing. Social computing is a broad term that encompasses a range to tools, including blogs, wikis, profiles (with social/professional connections), microblogging and discussion forums. Are you an advocate for social computing? A knowledge management practitioner? Join me on Tuesday, October 4th for a Twitter Chat I’ll be moderating at KMers.org. To participate in this Twitter-powered discussion you can use your favorite Twitter app with the hashtag #KMers or even easier — just sign in with your Twitter account at the live chat page on KMers.org. The chat will begin at 9am Pacific and run for an hour. During this chat we will discuss the differences and similarities between the social computing movement and knowledge management, how to reconcile and integrate the two, and the implications for KM over the next five years. Agenda - How do you define social computing, and how does it differ from KM? - What social computing tools and approaches are working well for you? - Where do informal social computing “communities” or team rooms fit in the context of communities of practice? - Should social computing tools be “managed?” - When does social computing and collaboration become KM? Is a boundary necessary or even beneficial? Interested? Join us, and you can follow me @jeffhester and keep the discussion going.
https://jeffhester.net/2011/10/03/social-computing-and-knowledge-management/
Slide1: Neutrinos, flavour and the origin of the Universe Slide2: Standard Model of particle physics has many remaining puzzles, in particular: 1. The origin of mass: the origin of the weak scale, its stability under radiative corrections, and the solution to the hierarchy problem. 2. The problem of flavour: the problem of the undetermined fermion masses and mixing angles (including neutrino masses and mixing angles) together with the CP violating phases, in conjunction with the observed smallness of flavour changing neutral currents and very small strong CP violation. 3. The question of unification: the question of whether the three known forces of the standard model may be related into a grand unified theory, and whether such a theory could also include a unification with gravity. Slide3: The Standard Model of Cosmology also has its own remaining puzzles, in particular: The origin of dark matter and dark energy: the embarrassing fact that 96% of the mass-energy of the Universe is in a form that is presently unknown, including 23% dark matter and 73% dark energy. 2. The problem of matter-antimatter asymmetry: the problem of why there is a tiny excess of matter over antimatter in the Universe, at a level of one part in a billion, without which there would be no stars, planets or life. 3. The question of the size, age, flatness and smoothness of the Universe: the question of why the Universe is much larger and older than the Planck size and time, and why it has a globally flat geometry with a very smooth cosmic microwave background radiation containing just enough fluctuations to seed the observed galaxy structures. Slide4: t b c s u d e The Flavour Problem Charge +2/3 quarks Charge –1/3 quarks Charged leptons A neutrino hierarchy Why are neutrino masses so small and mixings so large? What is the origin of quark and lepton masses/mixings? Do GUT/Family symmetries play a role? GUTs: GUTs Family Symmetry: Family Symmetry Nothing Slide7: Why are neutrinos so light? Light neutrinos Heavy particles A natural mechanism: Slide8: Type I see-saw mechanism Type II see-saw mechanism (SUSY) The see-saw mechanism Type II Type I P. Minkowski (1977), Gell-Mann, Glashow, Mohapatra, Ramond, Senjanovic, Slanski, Yanagida (1979/1980),Valle… Lazarides, Magg, Mohapatra, Senjanovic, Shafi, Wetterich (1981) Slide9: Type I see-saw for hierarchical neutrinos Technically need a small 23 sub-determinant: Why is the sub-determinant small? Why is the solar angle large? Need to understand: Right-handed neutrino dominance Single Right-Handed Neutrino Dominance : Single Right-Handed Neutrino Dominance If one right-handed neutrino of mass Y dominates then sub-determinant is naturally small Natural explanation of and large atmospheric angle if e~f Sequential dominance : Sequential dominance Same features as SRHND plus natural explanation of large solar angle if a~b-c Slide12: Constrained sequential dominance (plus previous) conditions Tri-bimaximal neutrino mixing Tri-bimaximal mixing from Constrained Sequential dominance …but what about charged lepton contributions to mixing? Harrison, Perkins and Scott – Paul’s talk Effect of small charged lepton mixing angles Antusch, SFK ’05: Effect of small charged lepton mixing angles Antusch, SFK ’05 If 13 angles are small have sum rule: q12+q13cos(d -p)¼ qn12 Typically 35.26± or 45± q13 and d then come from the charged lepton sector This means that d is irrelevant for leptogenesis (the bad news) Slide14: gives prediction for q12 as function of d Current 3s experimental range Tri-bimaximal value predicts maximal CP violation! (NOT zero CP violation!) e.g. tri-bimaximal neutrino mixing plus quark-lepton unification leads to …but d is predicted (the good news) Muon Flavour Violation : Muon Flavour Violation If SUSY is present then neutrino masses inevitably lead to lepton flavour violation due to radiatively generated off-diagonal slepton masses Borzumati, Masiero; Hisano, Moroi, Tobe, Yamaguchi; SFK, Oliveira; Casas, Ibarra; Lavignac, Masina, Savoy; … Unanswered cosmological questions: Unanswered cosmological questions Are neutrinos (partly) responsible for dark matter? Are right-handed neutrinos responsible for leptogenesis? (Silvia Pascoli) Are right-handed sneutrinos responsible for cosmological inflation? Are right-handed neutrinos responsible for dark energy? Slide17: WMAP Slide18: CMB power spectrum Galaxy power spectrum Tegmark (opposite), Wang, Zaldarriaga Galaxy structure limits neutrino mass 2dF Galaxy Redshift survey astro-ph/0204152 Slide19: Member of Physics WG Slide20: Kinney astro-ph/0406670 ? Slide21: Motivation for Inflation Horizon problem Flatness problem Relic removal Structure formation Present universe is inflating Slide22: slow roll of right-handed sneutrino in a false vacuum generates accelerated expansion in the very early universe Sneutrino inflation Slow roll parameters Right-handed sneutrino Slide23: astro-ph/0407372 Allowed regions of and Sneutrino chaotic (Antusch et al 04) (Yanagida et al 93) Slide24: Dark Energy and Right-handed neutrinos Barbieri, Hall, Oliver,Strumia hep-ph/0505124 Antusch, Eyton-Williams, SFK (in progress) The accelerated expansion of the Universe could be due to a tiny but non-zero dark energy of order the neutrino mass scale : A possible microscopic origin of dark energy is a quintessence field associated with a pseudo-Goldstone boson arising from the mass generating mechanism of right-handed neutrinos The model predicts Dirac neutrinos plus extra light 'sterile' neutrinos with interesting phenomenological and cosmological consequences (MiniBoone, BBN,…) Slide25: TOE (M-theory) GUT+Flavour theory See-saw model Muon flavour violation Leptogenesis Neutrino masses and mixings No direct link (need to go via see-saw model) RGE Summary Slide26: 1. The origin of flavour and the quest for unification: In terms of the unanswered questions of the Standard Model, whereas the LHC teaches us about mainly about the origin of mass, the Neutrino Factory will teach us about the problem of flavour and the question of unification. Neutrino masses are very small, and this probably means new physics beyond the Standard Model – the alternative is to have extremely small unexplained Yukawa couplings. The smallness of neutrino masses is commonly explained by the see-saw mechanism, which implies heavy right-handed neutrino Majorana masses. The explanation of the large lepton mixing angles can be readily accounted for in the see-saw mechanism, by the sequential dominance of right-handed neutrinos for example, leading to relations between elements of the neutrino Yukawa matrices. This adds information about the neutrino Yukawa matrices to the information already known in the quark and charged lepton sectors. When this information is taken all together it becomes possible to consider the problem of flavour in the framework of the question of unification. Theories of unification relate quarks to leptons, and motivate the measurement of lepton mixing angles to the same precision as the quark mixing angles. (Antusch, Pascoli, SFK) Discussion… Slide27: 2. The origin of matter in the Universe: In terms of the unanswered questions of Cosmology, whereas the LHC may teach us about the origin of dark matter, a Neutrino Factory may help to provide the solution to the problem of matter-antimatter asymmetry. The basic scenario assumes the see-saw mechanism and heavy right-handed Majorana neutrinos, which are produced in the early Universe and subsequently decay resulting in lepton-antilepton asymmetry in the early Universe, which subsequently becomes converted into baryon-antibaryon asymmetry. The asymmetry requires CP violating phases in the couplings of right-handed neutrinos. The relation between these phases and the oscillation phase is model-dependent. In a particular (GUT ) theory of flavour there may or may not be a relation (if q13 is small there is no relation) (Pascoli, Antusch) 3. The origin of the Universe: The question of the size, age, flatness and smoothness of the Universe is commonly answered by Inflation. The relation of Inflation to neutrino physics (if any) is unclear, but it has been suggested that the right-handed sneutrino (the superpartner to the right-handed neutrino) could be a suitable candidate for the inflaton field. (Antusch, SFK) 4. The origin of dark matter in the Universe: There are strong cosmological limits on the neutrino mass scale from galaxy structure formation – ways out? (Hannestad) 5. The origin of dark energy in the Universe: There may even be a connection between neutrinos and dark energy. The motivation is that the energy scale of dark energy is about , which is similar to the possible mass of some neutrino state e.g. the solar neutrino mass in hierarchical models. Models have been constructed which have experimental implications.(Antusch, SFK) Slide28: These are not disconnected subjects – the plan is to write a coherent document which makes a strong theory case for a neutrino factory The case must be both scientifically sound, and be appealing to a wide readership The main goal main is not to write refereed scientific papers, but this possibility should not be excluded if interesting new results emerge, especially if this benefits the non-tenured authors – in any case such studies frequently stimulate new research Interactions between members of a particular subgroup, and between different sub-groups is essential since the science is interconnected. Videos Incriveis do Whatsapp 76 - Duration: 0:18. Videos Zap 16 views. 0:18 Os vídeos mais incríveis do Whatsapp 12 - Duration: 0:14. Opa ... Read more www.sfk-components.com Read more Giáo Xứ Đức Mẹ Việt Nam(Riverdale,Georgia) First Holy Communion Mass). Read more SFK-112DM datasheet pdf, Selling leads from all over the world, ChinaICMart is the world's biggest IC trading marketplace on the internet. We offer finest ... Read more • výborný výkon celého hostingu • vysokou dostupnost služeb • nové administrační prostředí • rostoucí znalostní bázi • žádnou ... Read more SFK Lyn; Athletics club: Full name: Ski- og Fotballklubben Lyn: Founded: 3 March 1896: Ground: Kringsjå kunstgress, ... Other sports like ice hockey ... Read more Shadowfang Keep, once the castle and home of Baron Silverlaine, fell prey to the mad Archmage Arugal and his pet worgen.
http://www.slidesearchengine.com/slide/sfk-ic
Buried in CAA is a section on college-student aid dubbed “FAFSA Simplification.” It reduces the number of questions on the Free Application for Federal Student Aid (FAFSA) form from 108 to 36. It affects your college funding financial plan starting in 2022. A FAFSA form must be completed by current and prospective undergraduate and graduate college students to determine their eligibility for student financial aid for a given academic year. The form must also be submitted to determine eligibility for many scholarships and merit-based college funding programs, in addition to need-based college financial aid. “The simplification of the FAFSA form effectively redefines how eligibility for aid will be determined,” says Kalman Chany, author of “Paying for College, 2022: Everything You Need to Maximize Financial Aid and Afford College.” “There will be winners and losers.” In changing the eligibility criteria, “simplification” is expected to set off financial and administrative difficulties for many students. Many families eligible for needs-based federal aid under the current criteria will no longer be eligible under FAFSA Simplification. Since 1986, Mr. Chany has authored and annually updated a book on college funding and financial aid. He says the new FAFSA formula will no longer boost aid for families with more than one child in college. This single adjustment may slash the amount of aid families receive by thousands per student. Another important change is that the FAFSA form will no longer consider pre-tax contributions to 401(k), 403(b) and other qualified retirement account assets. However, the FAFSA formula will continue to count contributions to traditional IRA, KEOGH, SIMPLE IRA, and SEP accounts in your adjusted gross income as untaxed income. The changes in the FAFSA formula were supposed to go into effect beginning with the 2023-2024 academic year. However, because of technology and other issues, the U.S. Department of Education has asked Congress to delay implementation of the law until the 2024-25 academic year. “The 2024-25 school year may seem far off, but aid eligibility that academic year will be based in part on your 2022 income, due to a two-year look-back for income,” says Mr. Chany of Campus Consultants in New York City. Aid calculations are based on individual student and family circumstances, and the new FAFSA formula that is scheduled to go into effect in 2024-25 could yet be delayed. However, it is prudent for parents and students to know about the major changes in the FAFSA formula coming in the months ahead and to begin planning now, even if you are not sure you will qualify for aid. Nothing contained herein is to be considered a solicitation, research material, an investment recommendation, or advice of any kind, and it is subject to change without notice. Any investments or strategies referenced herein do not take into account the investment objectives, financial situation or particular needs of any specific person. Product suitability must be independently determined for each individual investor. Tax advice always depends on your particular personal situation and preferences. You should consult the appropriate financial professional regarding your specific circumstances. The material represents an assessment of financial, economic and tax law at a specific point in time and is not intended to be a forecast of future events or a guarantee of future results. Forward-looking statements are subject to certain risks and uncertainties. Actual results, performance, or achievements may differ materially from those expressed or implied. Information is based on data gathered from what we believe are reliable sources. It is not guaranteed as to accuracy, does not purport to be complete, and is not intended to be used as a primary basis for investment decisions. This article was written by a professional financial journalist for Advisor Products and is not intended as legal or investment advice. This article was written by a professional financial journalist for Preferred NY Financial Group,LLC and is not intended as legal or investment advice. An individual retirement account (IRA) allows individuals to direct pretax incom, up to specific annual limits, toward retirements that can grow tax-deferred (no capital gains or dividend income is taxed). Individual taxpayers are allowed to contribute 100% of compensation up to a specified maximum dollar amount to their Tranditional IRA. Contributions to the Tranditional IRA may be tax-deductible depending on the taxpayer's income, tax-filling status and other factors. Taxed must be paid upon withdrawal of any deducted contributions plus earnings and on the earnings from your non-deducted contributions. Prior to age 59%, distributions may be taken for certain reasons without incurring a 10 percent penalty on earnings. None of the information in this document should be considered tax or legal advice. Please consult with your legal or tax advisor for more information concerning your individual situation. Contributions to a Roth IRA are not tax deductible and these is no mandatory distribution age. All earnings and principal are tax free if rules and regulations are followed. Eligibility for a Roth account depends on income. Principal contributions can be withdrawn any time without penalty (subject to some minimal conditions). ©2022 Advisor Products Inc. All Rights Reserved. Not found any published videos! Jericho Atrium, 500 N Broadway # 219 Jericho, NY 11753 Phone: +1 516-935-3434 Fax: 516-935-3454 Securities provided through American Portfolios Financial Services, Inc. Member: FINRA, SIPC. Advisory services offered through American Portfolios Advisors, an SEC Registered Investment Advisor. Preferred NY Financial Group LLC is not affiliated with American Portfolios Financial Services, Inc. & not affiliated with American Portfolios Advisors When you link to any of these websites provided here, you are leaving this site. We make no representation as to the completeness or accuracy of information provided at these sites. Nor are we liable for any direct or indirect technical or system issues or consequences arising out of your access to or use of these third-party sites. When you access one of these sites, you are leaving our website and assume total responsibility for your use of the sites you are visiting. Calculators are provided only as general self-help planning tools. Results depend on many factors, including the assumptions you provide and may vary with each use and over time. We do not guarantee their accuracy, or applicability to your circumstances.
http://pfgnyonline.com/index.php?option=com_apicontent&view=fbclist&id=5002&Itemid=110
The AIA NY Committee on the Environment (COTE) aims to lead, inspire and educate our members towards the dual objectives of Design + Sustainability. COTE organizes many engaging activities and events which focus on leading architects, outstanding 'green' buildings, current technologies and product research, and sustainable design practices. Our efforts are based on the belief that sustainability should be an essential part of the design process and fully integrated with all aspects of a building, including form, function, site, structure, systems and construction. We work in partnership with the National AIA COTE and are supporting the AIA 2030 Commitment by providing educational opportunities to further understand our role in a sustainable future. Leadership Under its previous leadership, Pat Sapinsley and Ilana Judah, COTE developed into one of the New York Chapter's most active committees. The current co-chairs seek to continue COTE's mission to provide our members with the knowledge and tools necessary to integrate sustainability into their design practices. In the process, we also hope to encourage those outside the design community to embrace sustainability and appreciate the value of good design. We continue to build upon three goals for the COTE committee: to offer educational opportunities, foster connections and build networks, and promote our message beyond the design community to champion sustainability and good design. Pat Sapinsley, AIA, LEED AP Christen Johansen, AIA, LEED AP BD+C 2015 AIA-NY COTE Steering Committee Members AIANY 2017 COTE Awards This first annual AIANY COTE Awards, held in December 2014, was initiated in order to promote greater understanding of regionally specific sustainable design strategies through transparency, comparative operational data, and compelling lessons learned that reveal and inspire new materials, technologies, and design solutions. In order to nourish the design community, entries reveal the direct impacts of their projects, share the tools developed along the way, engage in the redefinition of value, and illustrate challenges overcome during the process of design and construction. The 2017 COTE Awards will be launching on June 3, 2017. For more information, please visit the Awards Website. Programs and Events AIA-NY COTE would like to thank the Con Edison Energy Efficiency Program for being the underwrite of our 2017 program of events. Learn about the 2017 AIANY COTE programs here. Return to list.
https://legacy-aia.aiany.org/index.php?section=committees&prrid=20
Experiments with entangled photons have led the way in the burgeoning fields of quantum information, communication and computation in the last decade. Their biggest drawback has always been low photon-detection efficiencies, which has limited their potential applications. Now, a joint experiment by Australian and US labs has fixed this problem, doubling the previous record in entangled photon detection ratio to 62 per cent, and closing the detection “loophole” in the strange phenomenon of quantum steering. The experiment was conducted by researchers at The University of Queensland, Griffith University, the ARC Centre for Engineered Quantum Systems and the ARC Centre for Quantum Computation and Communication Technology in Australia; and the National Institute of Standards and Technology in Boulder, USA. Austrian physicist Erwin Schrödinger first introduced the term steering in 1935 to highlight the ability of certain quantum particles to influence—or steer—each other no matter how far they are apart. This striking effect is the result of quantum entanglement—a phenomenon that connects two particles in such a way that changes to one of the particles are instantly reflected in the other—something that Einstein famously described as “spooky action-at-a-distance”. Steering allows two parties to verify if they have received quantum particles that share this quantum entanglement—even if one of the parties cannot be trusted. However, if there are any loopholes—which occur due to problems with the experimental design or set-up—the parties will not be able to say that they have conclusively observed quantum steering. “We overcame the detection loophole—where not all the photons can be detected—by combining a highly-efficient entangled photon source with state-of-the-art photon detectors,” said Dr Marcelo de Almeida of The University of Queensland. These detectors—called transition edge sensors —were developed by Dr Sae Woo Nam and his team at the National Institute of Standards and Technology. “The absorption of a single photon in such detectors causes a tiny change in the temperature which is sensed using superconducting effects,” Dr Almeida said. “Closing the detection loophole requires efficiencies of above 50 per cent. "The remarkably high efficiency of 62 per cent achieved in our experiment allows us to demonstrate conclusive steering.” Dr Almeida’s UQ-based co-authors include PhD students Devin H. Smith, Geoff Gillett, Drs Alessandro Fedrizzi, Till J. Weinhold, and Cyril Branciard, and Professor Andrew G. White, all from the ARC Centre for Engineered Quantum Systems (EQuS) and the ARC Centre for Quantum Computation and Communication Technology (CQC2T), as well as Professor Howard M. Wiseman from Griffith University, also of CQC2T. This record-breaking achievement, published in Nature Communications today, brings the researchers a step closer toward achieving even higher detection efficiency levels in the near future. "If we can achieve 66 per cent, then we could perform secure quantum communication even if one party has untrustworthy equipment. Five years ago I would have thought that was impossible,” said Dr Almeida.
https://www.uq.edu.au/news/article/2012/01/australian-us-collaboration-leaps-ahead-catching-spooky-light
Abstract: Sub-seasonal climate forecasting (SSF) is the prediction of key climate variables such as temperature and precipitation on the 2-week to 2-month time horizon. Skillful SSF would have substantial societal value in areas such as agricultural productivity, hydrology and water resource management, and emergency planning for extreme events such as droughts and wildfires. Despite its societal importance, SSF has stayed a challenging problem compared to both short-term weather forecasting and long-term seasonal forecasting. Recent studies have shown the potential of machine learning (ML) models to advance SSF. In this paper, for the first time, we perform a fine-grained comparison of a suite of modern ML models with start-of-the-art physics-based dynamical models from the Subseasonal Experiment (SubX) project for SSF in the western contiguous United States. Additionally, we explore mechanisms to enhance the ML models by using forecasts from dynamical models. Empirical results illustrate that, on average, ML models outperform dynamical models while the ML models tend to be conservatives in their forecasts compared to the SubX models. Further, we illustrate that ML models make forecasting errors under extreme weather conditions, e.g., cold waves due to the polar vortex, highlighting the need for separate models for extreme events. Finally, we show that suitably incorporating dynamical model forecasts as inputs to ML models can substantially improve the forecasting performance of the ML models. The SSF dataset constructed for the work, dynamical model predictions, and code for the ML models are released along with the paper for the benefit of the broader machine learning community. Submission historyFrom: Sijie He [view email] [v1] Wed, 29 Sep 2021 06:34:34 UTC (3,209 KB) Full-text links: Download: (license) Current browse context: physics.ao-ph References & Citations a Loading... Bibliographic and Citation Tools Bibliographic Explorer (What is the Explorer?) Litmaps (What is Litmaps?) scite Smart Citations (What are Smart Citations?) Code and Data Associated with this Article Recommenders and Search Tools Connected Papers (What is Connected Papers?) CORE Recommender (What is CORE?) arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs and how to get involved.
https://aps.arxiv.org/abs/2110.05196
Over the years, lack of adequate power supply to rural communities has resulted in people living without electricity for years and businesses crippling without electricity. Over 85 million Nigerians do not have access to grid electricity, according to the World Bank, representing 43 per cent of the country’s population, making Nigeria the country with the largest energy access deficit in the world. The World Bank revealed that the lack of electricity supply has significantly affected citizens and businesses, resulting in annual economic losses estimated at $26.2bn (N10.1trn), which is equivalent to about two per cent of the country’s Gross Domestic Product (GDP). The World Bank Doing Business 2020 ranked Nigeria 171 out of 190 countries in getting electricity. Rural and coastal communities are most affected, prompting over-reliance on power generators with their ever-rising costs and health hazards. Many coastal communities in the Niger Delta area of Nigeria have been without electricity for decades. The people are majorly into fishing, which requires electricity for storage before selling. The people have waited for years without being connected to the grid. This has become a stumbling block to the growth of their businesses. Steven Ibikunle, the founder of Philipcom Hotel, has been using generators to power his hotel, spending a huge amount of money on petrol. “Before now, we were using a generator, and we used a lot of fuel as a result of that,” he said. Tari Jackson, a fish farmer, who has been living in Fish Town since 2002, said she started drying fish in 2003. “We are always drying fish every day and sometimes our fishes get spoilt because there is no electricity to keep them from getting spoilt, and as a result of that, we lose a lot of money”, he lamented. To address this, the Foundation for Partnership Initiatives in the Niger Delta (PIND), a non-governmental organisation (NGO) established in 2010 with initial funding from Chevron Corporation to promote peace and equitable economic growth in Nigeria’s Niger Delta region by forging multi-sectoral and multi-stakeholder partnerships at the regional, national and international levels is facilitating off-grid, low-carbon, low-cost solar solutions to meet local needs through the Foundation’s access-to-energy intervention to spur improved economic development through cost savings for small businesses and households, as well as improved standard of living for residents of these off-grid, last mile, coastal communities. Between 2015 and 2019, through its Access to Energy program, PIND assessed energy requirements and possible solutions for underserved coastal communities in the region and incentivised private renewable energy providers to develop business models specific to the last-mile customers, and fostered engagements between them and community stakeholders. This was done to secure buy-in for a demand-and-supply meet that assures long-term viability for the investors and boosts demand for renewable energy services. The Access to Energy programme aims to provide access to affordable renewable energy for households and businesses to improve productivity, increase income, trigger new jobs, and improve the quality of life for residents of the communities. PIND in 2019 facilitated the installation of a pilot 15kW energy cabin at Gbagira community in Ilaje LGA of Ondo State and has since facilitated the setup of five energy cabins in five other coastal communities. These communities include Molutehin community in Ilaje LGA, and Gbokoda community both in Ondo State which was funded through a grant from Chevron Corporation to power its Global Memorandum of Understanding communities using energy cabins; a 21.06kW solar hybrid energy cabin in Lomileju community and a 19kW energy cabin in the Obe-Jedo community in Ondo State; two 20kW solar mini-grids in Awoye and Odofado communities in Ondo State using funds leveraged from the Ilaje Regional Development Committee (IRDC); and 20kw of solar-powered energy cabin in Ogheye community in Warri North Local Government Area of Delta State. At the end of 2020, 1,082 underserved and off-grid coastal businesses and households had gained access to clean energy technologies for the very first time through PIND’s energy interventions. PIND’s Access to Energy Programme Manager Teslim Giwa said the energy cabins would provide reliable electricity to businesses and households in the communities. He revealed the Access to Energy program started when PIND concluded the five-year Appropriate Technology Enabled Development (ATED) programme. “Many of the communities have never experienced grid connection and a lot of them are located in the periphery of the coastline. They have lived in communities for years without electricity. Some communities in the past enjoyed stable electricity through localised energy systems as they have benefitted from wealthy individuals who donated generators to serve the communities,” he said. “We were able to convince communities to adopt the new solar system to generate electricity in their communities,” Giwa said. The energy cabins helped the communities to reduce business costs, extend their business hours, and power large-load appliances, said Kehinde Tayo Emmanuel, the Chief Executive Officer of Vectis Business Option Limited, one of the energy cabin installers. “The solar light is helping a lot. I used to use about two refrigerators before, but now I use three and all my systems are working very fine,” he said. Pa Malo Felix, the Olaja of the Ogheye community, was grateful for the installation of the solar energy cabin in the Ogheye community. “We love it and we are enjoying it,” he said. “Before the solar came, we had generators in this community, but due to the condition of fuel, we could not power the generator. Solar is with us and what we do is to recharge the solar. We love the solar here a lot, and we would want the solar to stay. So, I thank the people that have brought this solar to the community,” he concluded. The Executive Director of PIND, Tunji Idowu said the energy cabins would increase the productivity of businesses in the communities and enable them to earn more income, adding that the communities can retail the solar energy at a competitive rate to a diversity of small and micro-enterprises within those rural areas. “As the access to energy is arguably the holy grail of development, these installations allow a diverse group of beneficiaries in the communities to address basic energy needs and productive uses of energy at both household and rural enterprise levels. These will afford such typically agrarian and fishing communities to experience direct value addition to fish and agricultural produce while newer service industries are likely to emerge”. He also expects that the installations would serve as community hubs and integrators that facilitate electricity uptake for traditionally recognised rural livelihoods, and potentially large employers of rural people. “We further expect them to create a new set of livelihood opportunities while simultaneously providing a platform that can support other parallel community development interventions,” he said.
Local Stakeholders' Perspectives on Improving the Urban Environment to Reduce Child Pedestrian Injury: Implementing Effective Public Health Interventions at the Local Level This article considers strategies to reduce child pedestrian injury, focusing on ways to implement effective public health interventions at the local level. The authors stress that local-level public health interventions require action from multiple agencies, organizations and individuals. The authors sought local stakeholders' perspectives by conducting 20 in-person, key informant interviews with people who would be the likely advocates for environmental change to improve the pedestrian environment in one US city (Baltimore, Maryland). The people being interviewed considered implementing environmental pedestrian injury prevention interventions as best addressed by an informed citizenry working with local government. The authors discuss the importance of reframing child pedestrian injury risk as a livability issue, increasing awareness about the potential impact of environmental changes to improve public safety, and the need for a formal efficient process to facilitate communication between local government and other stakeholders. The authors conclude that effective advocacy will be needed to force this issue onto the political agenda and help funnel scarce resources into this vital area. - Availability: - Find a library where document is available. Order URL: http://worldcat.org/issn/01975897 - Authors: - Frattaroli, Shannon - Defrancesco, Susan - Gielen, Andrea C - Bishai, David M - Guyer, Bernard - Publication Date: 2006-12-1 Language - English Media Info - Media Type: Print - Features: References; - Pagination: pp 376-388 - Serial:
https://trid.trb.org/view/809468
When Pierre de Fermat famously complained that he didn't have space to write the proof of his famous “Fermat's Last Theorem”, he only ran out of space of the margin of a book. Now, a pair of mathematicians at the University of Liverpool in the UK have produced a 13GB proof that's sparked a debate about how to test it. The mathematicians, Alexei Lisitsa and Boris Konev, were looking at what's called the “Erdős discrepancy problem” (it's appropriate to point to Wikipedia, for reasons you'll catch in a minute). New Scientist describes the problem like this: “Imagine a random, infinite sequence of numbers containing nothing but +1s and -1s. Erdős was fascinated by the extent to which such sequences contain internal patterns. One way to measure that is to cut the infinite sequence off at a certain point, and then create finite sub-sequences within that part of the sequence, such as considering only every third number or every fourth. Adding up the numbers in a sub-sequence gives a figure called the discrepancy, which acts as a measure of the structure of the sub-sequence and in turn the infinite sequence, as compared with a uniform ideal.” For any sequence, Paul Erdős believed, you could find a finite sub-sequence that summed to a number bigger than any than you could choose – but he couldn't prove it. In this Arxiv paper, the University of Liverpool mathematicians set a computer onto the problem in what they call “a SAT attack” using a Boolean Satisfiability (SAT) solver. They believe they've produced a proof of the Erdős discrepancy problem, but there's a problem. After six hours, the machine they used – an Intel i5-2500 running at 3.3 GHz with 16 GB of RAM – produced what they offer as a proof, but it's inconveniently large, at 13 GB. A complete Wikipedia (see, I told you it was relevant) download is only 10 GB.
https://www.theregister.co.uk/2014/02/20/mathematicians_spark_debate_with_13_gb_erds_test/
Josh Plank joined WestPoint Financial Group in 2002 upon earning a degree in Finance from Butler University. He sought to join a premiere firm in Indianapolis and to work in a capacity that would leverage his natural ability to connect with people. As a financial advisor at WestPoint, he would have the opportunity to do both. Over a decade later, and now a partner in the firm, Josh feels the decision was the right one for him. Looking back on the early years of his practice, he acknowledges how much effort it took to establish a firm foundation. But like many successful entrepreneurs, he was motivated by a vision and put in the necessary time to get his business off to a strong start. The experience gives Josh a personal connection to the business owners whom he counts as clients today. He focuses much of his practice on helping entrepreneurs with business succession strategies. “Business owners care deeply about their businesses,” says Josh. “I enjoy working with them because they appreciate the help I can provide and there are vast opportunities for planning.” He also counts many physicians and local farmers as clients. “Doctors and farmers are small business owners, too,” he points out. Josh enjoys meeting with people, listening to their stories and helping them work toward achieving their goals. Josh believes in continuing to educate himself in his chosen field and has pursued several industry designations. He obtained the CFP® designation in 2007. He is also a Certified Life Underwriter designee (CLU) and a Chartered Financial Consultant desginee (ChFC). In 2020, Josh was recognized by GAMA International for outstanding leadership in the financial services industry. This prestigious award honors front-line leaders who have shown exemplary performance in their current positions and are emerging leaders in their companies. More recently, Josh was named MassMutual’s Sales Manager of the Year, the highest honor among all Sales Managers. This is the latest among all of Josh’s accomplishments that characterizes his vital contribution to the success and growth of WestPoint Financial Group. A steadfast Butler fan, Josh is loyal to his alma mater and doesn’t miss any basketball games. He is also a big fan of the Indianapolis Colts. Originally a native of Knightstown, Josh and his wife, Erin, reside in Zionsville, Indiana with their young children.
https://westpointfinancialgroup.com/associates/josh-plank/
We are teaming with a leading cabinet manufacturer in the Southeast in search of a company President to oversee all operations. This President will set the strategic direction and manage all the operational aspects of the company to achieve the budgeted plan and aggressive growth objectives. Excellent compensation and career growth opportunities. Candidates with a track record of successful General Management experience in high growth manufacturing setting will be given immediate consideration. OBJECTIVES: - Plans and directs all phases of manufacturing, production, warehouse, shipping, receiving, supply chain, purchasing, and inventory - Plans and directs all aspects of the organization operation policies, objectives, and initiatives - Active in business development and customer care to ensure client satisfaction, building of trust, improvement ideas and sales growth - Responsible for the short and long-term financial and operational goals - Develops and implements strategic plan and operation plan including clear objectives, metrics, and monitoring for the organization in every department - Strategic thinker who is constantly scanning environment (internal and external) for changes in the marketplace and consumer trends. - Provides day to day management and interpersonal communication that mirrors the company’s mission and values - Inspires trust and respect in order to achieve a fun and productive culture that contributes to retaining employees and makes us an employer of choice - Meets with key partner (suppliers, vendors) to develop long term relationships - Models importance of defining and meeting internal and external client satisfaction - Contribute effectively to company’s long-range manufacturing plans, and ensure that the facility adheres to the plan, reacting to short-term range changes when needed - Manage manufacturing performance to ensure that production goals and finished goods inventories are achieved QUALIFICATIONS: - Bachelor’s degree in Business or Finance required and Master’s degree preferred - 10-15 year’s general management experience in manufacturing or homebuilding sectors - Demonstrated understanding of principles and applications associated with manufacturing operations - Strong leadership and interpersonal skills - Demonstrates extensive knowledge of industry best practices and trends - Demonstrates in-depth understanding and application of GMP principles, concepts, best practices and standards - Proficient in Microsoft Office, Word, Excel, Outlook - Strong familiarity with current industry-specific competitive strategies and best practices BENEFITS:
https://matchbuilt.com/jobs/president-cabinet-manufacturer-jacksonville/
Create a set of questions that touch on a variety of viewpoints related to the event. 2. Collect live opinions Invite the audience to enter their opinions to your questions before entering matchmaking. 3. Create virtual discussion groups Our system uses machine learning to intelligently match people into maximally diverse groups based on user opinions.
https://www.mixopinions.com/
That is the question. We did an experiment to provide an answer to this time old question (ok, sure, we’re borrowing from Shakespeare). For this experiment, we used our favorite Madagascar beans. I think we’re now about halfway done with the giant bucket! Let’s post some hypotheses about the two batches: Cocoa butter This batch we’d expect to be smoother. We’d also expect it to pour better for tempering and have a more “chocolatey” taste. That’s the case for our first batch with cocoa butter, the Venezuelan batch. Without added cocoa butter (creative title, I know…) This batch should have a darker flavor, since it has a higher ratio of cocoa mass to cocoa butter. Remember that even chocolate without added cocoa butter still has cocoa butter in it. Usually, chocolate without added cocoa butter sits at around 50% cocoa mass to 50% cocoa butter, plus any additional ingredients like sugar. We go into this in more detail in this post. So, what really happened? We started with 654 grams of winnowed Madagascar beans plus 174 grams of sugar in the Premier Wonder Grinder from 9:40pm Monday night until 7:40am Wednesday morning. That said, we had a 2.5 hour break Tuesday night when Richard’s parents came over for dinner. (It was nice to listen to some nice jazz for a little while rather than the whirring of the melanger.) On Wednesday morning, we poured out 303 grams of the mixture and started the tempering process for what we’ll call Batch A. Richard’s plan was to imitate a tempering machine by stirring continuously as the temperature slowly drops. He got it all the way down to 82 by spinning the bowl on our quartz table, allowing the chocolate to seep up along the much cooler sides of the bowl. While he stirred and cooled, I melted the cocoa butter for the other half of our experiment (Batch B). Our enthusiasm to get the temperature back up to 90 after successfully dropping it to between 80 and 82 in the bowl (without table tempering) unfortunately led to three consecutive tempering failures, where we raised the temperature significantly too high in the microwave. Once to 122 and twice more to about 100, requiring us to start the process over again. I guess the fourth time is a charm, because that time we got the temperatures and power levels right, ending up with a 90 degree batch to mold. The mixture seemed particularly thick when we were molding, but our thermometers were telling us we had the right temperature. And in the end, the molding process ended up pretty lumpy, but we have beautifully tempered 79% chocolate in Batch A. Meanwhile, for Batch B, we poured about 38 grams of cocoa butter into the melanger and released the pressure on the stone wheels. We let it keep running for the next hour while we worked on those many tempering attempts. With 427 grams that came out of the melanger at 86 degrees, we stirred in the same way as the previous batch and reduced the temperature to 81. This time, on the first try, we got it back up to 90 in the microwave and were ready to temper! We poured it out into the molds and it came out the perfect molding consistency – dripping evenly into the molds and easily adjusted with some wiggling to get the bubbles out. The final product of Batch B is an 81% chocolate (154g natural cocoa butter + 38g added cocoa butter + 154g cocoa mass + 82g sugar). So, what is the ultimate difference in percentage between the two batches? Batch A is considered 79% with about 40% each of cocoa mass and cocoa butter. Batch B, on the other hand is considered 81% (just 2 measly percentage points higher than Batch A), but has 45% cocoa butter and only 36% of cocoa mass. Big difference! And once again, both batches were beautifully tempered, despite some funky shapes in Batch A: You may be wondering, how we went from such tempering issues to the gorgeous, shiny, hard bars you see below. Well, besides our new version of table tempering (in a bowl), the big winner of our tempering challenge is Thomas Forbes with the brilliant suggestion of about 10 minutes in a refrigerator immediately after molding. We know many of you seconded his idea, but he was the first! Thomas, message us privately (through the Join the movement page) to claim your prize! Our hypotheses were mostly correct, though we have a hard time telling the difference in flavor between the two batches. We’ll have to invite some friends and family to give us their honest opinion. We’ll keep our loyal readers updated!
https://rootchocolate.com/2014/12/06/cocoa_butter_question/
Abstract: Human population has exerted enormous impacts on biodiversity, even in areas with “biodiversity hotspots” identified by Myers et al. (2000). For instance, the population density in 1995 and the population growth rate between 1995 and 2000 in biodiversity hotspots were substantially higher than world averages, suggesting a high risk of habitat degradation and species extinction (Cincotta et al. 2000). Many regression models have been built to establish correlated relationships between biodiversity and population (e.g., Forester and Machlis 1996; Brashares et al. 2001; Veech 2003; McKee et al. 2004). These models are important and necessary, but they use aggregate variables such as population size, density, and growth rate, which may mask the underlying mechanisms of biodiversity loss and could result in potentially misleading conclusions. For example, does a declining population growth reduce the impact on biodiversity? Although global population growth has been slowing down, household growth has been much faster than population growth (Liu et al. 2003). The continued reduction in household size (i.e., number of people in a household) has contributed substantially to the rapid increase in household numbers across the world, particularly in countries with biodiversity hotspots. Even in areas with a declining population size, there has nevertheless been a substantial increase in the number of households (Liu et al. 2003). More households require more land and construction materials and generate more waste. Furthermore, smaller households use energy and other resources less efficiently on a per capita basis (Liu et al. 2003). Thus, impacts on biodiversity may be increased despite a decline in population growth. To uncover the mechanisms associated with human population that underlie biodiversity loss and provide valuable information for biodiversity conservation, it is crucial to go beyond regression analyses and examine how demographic (e.g., population processes and distribution) and socioeconomic factors affect biodiversity at the landscape level. As many effects may not surface over a short period of time, it is essential to conduct long-term studies. However, landscape level longterm studies are costly, and it is very difficult to conduct experiments on some types of subjects, such as people. Fortunately, systems modeling has become a useful tool to facilitate landscape-scale long-term simulation experiments (Liu and Taylor 2002). For this chapter, we applied a systems model we had developed (An et al. 2005) to study the long-term ecological effects of demographic and socioeconomic factors in Wolong Nature Reserve, southwestern China. URL: Long-Term Ecological Effects of Demographic and Socioeconomic Factors in Wolong Nature Reserve (China) DOI: 10.1007/978-3-642-16707-2_10 Type of Publication: Book Chapter Editor(s):
http://chans-net.org/publications/long-term-ecological-effects-demographic-and-socioeconomic-factors-wolong-nature-reserv
The cynic in me thinks it’s typical that Swansea’s best performance of the season coincided with a career-endingly poor performance from referee Stuart Attwell. This was a game Swansea should have won. Wilfried Bony had the ball in the net. To say Swansea don’t score often is as big an understatement as Attwell’s call was a travesty, so it was particularly frustrating to see that goal wiped out by just one in a game-long line of satin-soft calls against Swansea players. Swansea foul on average 10.4 times per match, but Attwell blew for 18 against the Welsh side last Saturday, and only 6 for Bournemouth. Neither side has a reputation for physical play, so that 3:1 imbalance in fouls would be eye-opening enough on paper. In the flesh, it was much worse. Almost every time a Swansea player made the slightest physical contact with an opponent, the Bournemouth player would hit the deck, and Attwell would whistle. When Bournemouth actually did foul Swansea players — the worst instance ending with Roque Mesa’s head cut open on Josh King’s swung elbow — Swansea got nothing. Andy Carroll has an advent calendar and inside door 25 is the next West Ham fixture that Attwell will “officiate”. This kind of frustration is fruitless of course. Nothing can change that result, but it is hard enough to swallow this kind of blatant bias when your team is creating enough chances to overcome it. Swansea barely create goal scoring chances in an even contest; having to fight the referee as well makes it an impossible task. All of this poses a question about the merits of physical play. I’m not about to condone deliberate violence, but here’s a thought: referees are going to call x number of fouls in a game regardless of how clean a team plays. I’m sceptical any team has gone through a game without committing a single offence (feel free to tweet me if I’m wrong). Referees are only human, and “make up calls” are a natural response. We’ve all seen games where the ref seemed to suddenly penalise one team unfairly because they felt guilty of showing bias towards the other team previous to that point (unless that ref is Stuart Attwell). So if you know you can expect to be penalised regardless of actual intent (or even actual fouls if Attwell is in charge), wouldn’t you rather at least “earn” those penalties? Get the advantages committing a foul should bring? If you’re getting the punishment anyway, mightn’t you at least also do the crime? Had Swansea actually fouled Bournemouth 18 times on Saturday, they would have had a lot more of the run of play, because real fouls hurt. You put a proper lick on a guy, and he’ll think twice about committing to 50-50 challenges for the rest of the game. You give a guy a bruise in a certain place or a dead leg and he’ll lose half a yard of pace. These are dark arts, but if it’s a choice between leveraging fouls to your advantage, or allowing a biased referee to privilege your opponent at your expense, what would you rather do? Bournemouth got 18 free kicks without having to pay a price for most of them on Saturday, and they were still awful. Swansea should have won, and it’s hard to just shrug it off as one of those things, or say “it’ll all even out over the season”. Referee displays this bad don’t even out. The fact this ref already had a history of awful refereeing only makes it worse. Stuart Attwell aside, Swansea should at least be encouraged that they might yet break out of their funk. The level of effort on Saturday was much higher, the pressing was back, the desire was back. Roque Mesa is a warrior, and it is worth playing him for his hwyl alone. All these players have made mistakes this season, but few can match the small Spaniards guts. Ki Sung-Yeung — the most lackadaisical man in Swansea since I last lived there — almost started a fight, and could easily have seen red for shoving the referee (the fact Attwell didn’t dismiss him suggests he knew he owed Swansea something). Bony Mk II is showing that he can be Bony Mk I again. The side still don’t create enough shots, so it’s not as though one energetic performance against a team of nonchalant cheaters means everything is better now, but it’s a start. Confidence has to grow from somewhere, and Saturday is as good a place as any. Swansea have always fared better as the underdog, and if the side can carry the sense of injustice from Attwell’s farce into the next few games, perhaps they can rediscover some fighting spirit, and with it some killer instinct. Why does it feel so wrong to type “killer instinct” in a blog about Swansea?
http://www.maxwellhicks.com/2017/11/28/swans-0-stuart-attwell-1/
limited within ever narrowing parameters. With the greater reach of information technology, and with our gathering insights into the mechanics of the universe, this is about to change... The new generation of humans is capable of grasping the critical nature of our existence here on planet earth. To do so we must appreciate the multiple stages that we morph through in our quest for self development. No longer is a virtual 'caste' system necessary to say who can (and cannot) do what. Within ourselves we now discover the full potential of being human - our critical metamorphosis from the merely living to a much more fulfilling existence bordering on the Divine! This is the great awakening, and all humans are equally a part of it... Visually we can think of the upcoming transformation as the tale of two spirals. The first spiral is our biological DNA which is largely responsible for bringing humanity to its current capabilities. The second is the spiral of Divinity, expressed as the ongoing rotation of the Tao Cycle over higher and higher levels of existence. To bridge between the two, we need to build up our Cultural DNA - those pieces of shared knowledge that differentiates modern humans from our cavemen forebears. It is by building up this knowledge, these gems of existential wisdom about the nature of our human existence, that we can reach our potential - individually and also collectively as the Human Civilization. The Tao Cycle philosophy, upon which this book is based, is a melding of the Eastern 'cyclic' interpretation of nature with the more Western 'one-way' arrow of development. For its part, the 'Law of Attraction' plays an essential role in how the Universe responds to the aspirations of the Human. In this book we move on to the timeless nature of the relationship between the Aspiring Human and the Inspiring Universe, and 'why' the opportunity we face at our current juncture of civilization is so monumental in its scope. The philosophy presented here, and intended to be developed further in the Aspiring Human series, reveals the hidden mechanics of self-development. It clearly demarcates the transitions we must go through as we reach for a measure of Divinity in our daily lives. This book is dedicated to the Aspiring Human - those amongst us with a keen desire for self-improvement. It is also intended to provide a spiritual framework within which people of all philosophical backgrounds could work together - as we hope to bridge our human influence onward to other planets, to the stars, and possibly far beyond... WHAT WE RISK WITH THE STATUS QUO: The Tao Cycle has four nodes that form the Aspirational Trajectory for Humans. The nodes are: 1. Individuality / self-sufficiency 2. Affluence (economic sufficiency) 3. Universality (Yogic Empathy) 4. Germinal (Spiritual Metamorphosis) Much of humanity still struggles with developing their Individuality - especially when it comes to education and skill building. Some societies are able to move beyond Individuality, to Affluence, but the relative percentage of earth's population that get there is still very miniscule. THESE TWO NODES - WE HUMANS SHARE WITH ALL ANIMALS THAT TAKE CARE OF THEIR YOUNG!! What sets us Humans apart is the potential to move purposefully on to the nodes of Universality (needed for real peace), and then on to the Germinal node (needed to really change our civilization into a level of Divinity). THIS POTENTIAL IS HIGHLY UNDER-UTILIZED. If the human mindset and the values that we worship (e.g. popular entertainment themes) are stuck at the Individuality and Affluence nodes; cultural, political and economic wars will rage on - dividing humanity - and sapping its onward progress. The real reward, individually as well as collectively, is for us to move in ever greater numbers towards Universality and subsequently metamorphose ourselves into a civilization of cosmic proportions (via the Germinal Node). The Spirituality that we need to achieve the last goal is nothing more than the ability to deal with possibilities verging on the infinite. This no longer remains the sole purview of religious aristocrats... AS HUMANS, WE ALL ARE A PART OF THIS TREMENDOUS ADVENTURE! intrinZ PUBLISHING The Riddle of The Sphinx Relevance Today Further Reading: In Our Own Image - Humanity's Quest for Divinity via Technology,
http://sphinx.intrinz.com/Relevance.html
When developing houses or flats – either new build developments or where existing buildings are converted into dwellings, it is essential that sound insulation between the dwellings is carefully considered. All new residential properties must comply with The Building Regulations Approved Document E. This aims to ensure a ‘reasonable’ standard of sound insulation between dwellings. However, complaints about excessive noise or nuisance is an ongoing issue for Local Authorities and a common cause of disputes between residents. Approved Document E: an overview Approved Document E: Resistance To The Passage Of Sound is divided into four sections covering the following aspects: Requirement E1 primarily relates to sound transmission to residential properties, either from adjacent dwellings or from adjoining commercial or communal areas. Minimum performance standards are set which should be demonstrated by testing on site. Requirement E2 sets minimum standards for internal walls and floors within a dwelling. Unlike E1, these are laboratory tested values and selecting a suitable construction method is considered acceptable. Requirement E3 aims to ensure that sufficient acoustic absorption is incorporated into the common areas of blocks of flats. Finally, E4 sets a legal requirement for the acoustic conditions in schools to be appropriate for the intended use. The guidance applies to new-build properties, buildings undergoing conversion (termed ‘a material change of use’, examples include offices being repurposed as flats, etc.), and in certain cases for alterations to existing residential properties. Sections 2, 3, and 4 of Approved Document E provide example constructions for separating walls and floors that, when properly designed and installed, should be suitable to achieve the minimum performance standards. However, it is important to remember that your Building Control Officer will consider whether the pre-completion sound insulation tests on site ‘pass’ the Approved Document E standards. Approved Document E: the minimum expected standards It is important to remember that Building Regulations specify the minimum standards that a building must achieve to be considered suitable for habitation. The measures outlined in Approved Document E are designed to provide a minimum reasonable performance and, therefore, must be adhered to when any new-build or renovation residential project is undertaken. In some circumstances, it will be appropriate to implement measures that achieve a higher specification of acoustic insulation that go far beyond those outlined in Approved Document E. This could be the case when a development is aiming to achieve BREEAM credits, if required by a Local Authority planning condition, or simply where a developer aims to provide high quality dwellings for future owners and occupants. The problem of reverberation Reverberation is another word for ‘echo’: the reflection of a sound from a hard surface. High levels of reverberation can be disorienting or distracting as the sound ‘overlaps’ with the original sound, particularly in communal areas of residential properties, such as large entrance foyers or multi-storey stair cores. Approved Document E provides two methods to satisfy Requirement E3; the simplified Method A, which requires a minimum area of acoustic absorption to be incorporated into entrance halls, corridors, and stairwells. Method B uses a calculation procedure to determine the amount of absorption required and can allow greater flexibility than Method A. How a qualified acoustic consultant can support your residential construction project Complying with Approved Document E is vital when undertaking a residential building project. The costs of rectifying failed sound insulation testing can be significant, particularly as they come at the end of the project meaning redecoration, kitchen or bathroom fittings could have to be removed and refixed, or when they might hold up the sale of the new properties. A professional acoustic consultant will be able to advise whether your building’s construction methods and flanking and junction details will be suitable to meet the required standards. They can also ensure that the proposed construction details are the most suitable and cost-effective. Often ‘acoustic’ products are not necessary and standard building products would be sufficient or even provide a better standard of sound insulation at a fraction of the cost! Employing a qualified acoustic consultant early in the design stage can save £000’s and give you peace of mind. At ACA Acoustics, we can provide an acoustic design review of your development and then undertake pre-completion sound insulation testing required by Building Control for your development: While the cost of the tests may be a factor when choosing a sound insulation testing company, it’s vital to select an acoustic consultancy who has experience of providing design advice, both at the earliest stages of development planning and during construction which can far outweigh any minor savings that could be achieved for the tests alone. The acoustic consultant should also have the knowledge to be able to offer appropriate guidance on remedial work should the airborne or impact sound insulation tests fail. Contact ACA Acoustics today To find out more about our acoustic consultancy services to ensure your residential building project complies with Approved Document E of the Building Regulations or to book in your sound insulation tests, please get in touch today.
https://www.aca-acoustics.co.uk/uncategorized/importance-of-housing-development-sound-insulation/
My name is Zlatko Olić I am an expert in human resources development, specializing in sports. I enjoy working with individuals and teams, helping them connect with their potential and find flow in their performance, whether they are athletes, sports coaches or sports clubs. I have always been interested in knowledge related to the functioning of the human mind. How it works, by what patterns, consciously and subconsciously. I work dedicatedly on mental preparation in sports through mindfulness, flow and coaching. EDUCATION AND WORK EXPERIENCE I GRADUATED FROM THE YOUTH ACADEMY OF CROATIAN FOOTBALL CLUB RIJEKA AND I LIKE SPORTS VERY MUCH After graduating from the Faculty of Economics in Rijeka, I worked in various international companies, such as L'Oréal and Keune, where I also attended numerous trainings. While gathering valuable business experience, I was lucky to meet Domagoj Matijević, an expert in the development of human and system potentials. Under his mentorship, I completed, in Zagreb, a four-year In Optimum - School for the education of professional trainers in the field of human resources development and I am constantly educating myself through the Tranceframing school program and other programs. As a human resources development expert, I have over 10,000 hours of individual work with people. Also, as a longtime coach and lecturer, I naturally developed the idea to integrate my knowledge and experience into the Just Flow program. As I have always loved working on a practical level, I opened my own private practice. I am currently collaborating with leading Croatian sports clubs, coaches and athletes. In sports, I find moments in life that I truly enjoy. I also believe that enjoying the game is key for anyone involved in sports at all levels.
https://justflow.org/en/about-me/
Q: (a) What is the maximum energy in eV of photons produced in a CRT using a 25.0-kV accelerating poten... A: Given: Accelerating potential , V =25 kV = 25000 V 1 eV = 1.6 x 10-19 J plank's constant, h = 6.63... Q: Applying X-ray for diagnosis or therapy requires a good understanding of the effects the radiation c... A: Click to see the answer Q: B = 5.8x10-5 Tesla, θ=2°. How fast must the proton fly, so that the magnetic force balances its wei... A: Given: Magnitude of magnetic field (B) = 5.8×10-5 T. Angle (θ) = 2 Mass of proton (m) = 1.67×10-27 k... Q: What is the pressure at a depth of 110 m in the ocean? The density of seawater is 1. 03 x 10 kg/m. P... A: Click to see the answer Q: Calculate the potential energy of the +2µC charge at point P. Calculate the work done in moving the ... A: Click to see the answer Q: Theorists have had spectacular success in predicting previously unknown particles. Considering past ... A: Experiments done at world class facilities like CERN, Fermi Labs etc have proven many theories right... Q: A collapsible plastic bag (figure below) contains a glucose solution. If the average gauge pressure ... A: Click to see the answer Q: If V=20 V, C1= 3μF, C2= 2μF, C3= 2μF, C4= 4μF, C5= 2μF and C6=3μF and each capacitor has a dielectri... A: The capacitance of the capacitor after inserting the dielectrics be: Q: A constant diffusion current of electrons is established through a silicon semiconductor material. T... A: Given:- Jn = -0.8 A/cm2 = -8000 A/m2 n = 1.5 x 1015 /cm3 = 1.5 x 1021 /m3 De = 35 cm2/s = 35 x 10-4 ... Q: To save money on making military aircraft invisible to radar,an inventor decides to coat them with a... A: Click to see the answer Q: A 0.75-kg block slides on a rough horizontal table top. Just before it hits a horizontal ideal sprin... A: Click to see the answer Q: When a 1-Ω resistor, a 2-Ω resistor, and a 3-Ω resistor, are connected in series to a common DC powe... A: Draw the circuit diagram of the arrangement as: Q: Define and make clear distinctions between the terms neutron, nucleon, nucleus, nuclide, and neutrin... A: Nucleus:- Its is the center of an atom which consists of protons and neutrons. It is around this, th... Q: The only combination of quark colors that produces a white baryon is RGB. Identify all the color com... A: Colour quarks are fundamental particles. The colours assigned to quarks have three values namely red... Q: A container is filled to a depth of 18.0 cm with water. On top of the water floats a 29.0-cm-thick l... A: Click to see the answer Q: The position of a 0.5 kg object attached to a spring in meters is given by: x(t) = 5 cos(2t + 0.5π).... A: Click to see the answer Q: Still in DC Steady State, ℰ=11 volts, R1=46 Ω, R2=51 Ω, and R3=37 Ω, and L=6 Henry. Calculate I1. A: It is given that Q: A 4 kg object is attached to a spring and is oscillating on a horizontal surface. When the object ha... A: Click to see the answer Q: An x ray tube has an applied voltage of 50 kV. (a) What is the most energetic x-ray photon it can pr... A: Click to see the answer Q: 7. Resolving ‘power’ of an electron microscope versus optical (photon) microscope: If a resolution ... A: Click to see the answer Q: deal with a mass-spring-dashpot sys- tem having position function x(t) satisfying Eq. (4). We write ... A: Given information: Here, x0 and v0 are the (initial condition) position and speed of the mass m at ... Q: QUESTION 10 Two inductors are connected in series to a 120-V, 60-Hz supply. The values of the induct... A: Click to see the answer Q: Wave-particle duality of light extends to matter particles by the de Broglie hypothesis. If an elect... A: Given: Temperature , T = 2.725 K Q: Can you answer question 2 part c with algebra? A: Given: Length of the pole ( proper or rest length ) = 5 m Velocity 'v' = 4 c / 5 Length of the barn... Q: If a = 60 cm, b = 80 cm, Q = 8.0 nC, and q = 4.0 nC, what is the magnitude of the electric field at ... A: Click to see the answer Q: If the universe is infinite, does it have a center? Discuss. A: The universe is infinite, and what is know about the universe is gathered by analysing the observabl... Q: In a given fluid, positive ions, each with two excess protons, move towards right at a steady rate o... A: Click to see the answer Q: The rotor on a helicopter turns at an angular speed of 3.06 ✕ 102 revolutions per minute. Express th... A: Click to see the answer Q: an 80 kg man is on a ladder hanging from a balloon that has a total mass of 320 kg (including the ba... A: Since the initial momentum is zero and in order to conserve momentum, if the person climbs up then t... Q: Thank you A: Click to see the answer Q: 6.11 The loop shown in P6.11 moves away from a wire carrying a current I1 = 10 A at a constant veloc... A: Given: I1 = 10 A R = 10 Ω velocity u = 7.5 m/s ( in y direction ) Rest all as shown in diagram. Q: List two types of problems that could suitably be modeled by Physical models. A: We are asked to list two types of problem that could be modeled by physical model. They are listed b... Q: Help me please A 15-lb force acts at point A on the high-pressure water cock. Replace this force wi... A: Given: At point A acts 15 lb force. Q: An APOLLO crew left a flat mirror reflector on the surface of the moon (for all you deniers out ther... A: Given : distance between earth and moon, d = 3.83 × 108 m speed of moonlight, c = 3.0 ×... Q: A spacecraft is traveling at 0.900c relative to earth. An astronaut’s heart rate is measured on the ... A: Since the observer is in the same moving frame of reference as that of the astronaut,the heart rate ... Q: A far-sighted student has a near point of 1.5 m. Calculate the focal length (in cm) of the glasses n... A: Click to see the answer Q: A certain fluid has a density of 1075 kg/m3 and is observed to rise to a height of 2.1 cm in a 1.0-m... A: Click to see the answer Q: 10. What is the event horizon radius [m] for the sun if it were to collapse to a Schwarzschild blac... A: Click to see the answer Q: How is the de Broglie wavelength of electrons related to the quantization of their orbits in atoms a... A: The shell available for the electron for revolution is quantized which means they occur in discrete ... Q: You wish to produce upright virtual image of an objeaobject with the given magnifications using a di... A: Click to see the answer Q: The quarks in a particle are confined, meaning individual quarks cannot be directly observed. Are gl... A: The Gluons confined as well like quarks. Gluon is an elementary particle which acts as the exchange ... Q: In the circuit shown, R, = 3 N, R2 = 2 N, R3 = 5 N, ɛ, = 4 V, ɛ2 = 10 V and ɛ = 6 V. Find the curren... A: The circuit is shown as, Applying, the KCL at node A. Va = Vb = Vc = V Vf = Ve = Vd = 0 Q: An antenna has a gain that is 13 times better than an isotropic antenna. Calculate the gain of this ... A: Given : gain of antenna with respect to an isotropic antenna, G = 13 Let the power gain of antenna b... Q: You have a system of a positively and a negatively charged objects (+q1and -q2) separated by distan... A: Click to see the answer Q: A household circuit rated at 120 volts. Five 40 watt light bulbs are connected in parallel. What is ... A: Given: Circuit rate (V) = 120 V. Power of bulbs (P) = 40 W. Connection in parallel. Quantity of bulb... Q: When a nucleus α decays, does the α particle move continuously from inside the nucleus to outside? T... A: When a nucleus a decay occurs then the total number of nucleons that can get out of the nucleus from... Q: Let there be four different resistors : W, X, Y , and Z . How many different electrical circuit arra... A: Since there are four resistors here named as W, X, Y , and Z. Now,We know that the probability for 4... Q: A metal wheel with an area of 30 m2 spins at 2 rpm about a vertical axis at a place where Earth’s ma... A: The magnetic field passes is along the vertical axis, and its is perpendicular to the area vector. C... Q: what factor does the weight of each rider increase or decrease at the top of the loop (compared to t... A: Click to see the answer Q: Speedometer readings for a motorcycle at 12-second intervals are given in the table. t (s) 0 12 ... A: Hey, since there are multiple subparts question posted, we will answer first three questions. If you...
https://www.bartleby.com/questions-and-answers/a-color-television-tube-also-generates-some-x-rays-when-its-electron-beam-strikes-the-screen.-what-i/9f5fa0e7-636b-48d4-849b-175f8f8e9d99
In the 30 years since the first British Museum volume dedicated to the scientific study of early metallurgy, there has been great progress in understanding the diversity of processes by which ores were mined and smelted as well as significant advances in the methods of study of these. In particular, the experimental replication of ancient processes has assumed ever greater importance. This volume arose from the conference Metallurgy: A Touchstone for Cross-cultural Interaction which took place at the British Museum to celebrate the enormous contribution to the study and understanding of metallurgy made by Paul Craddock during his 40 years at the Museum. The papers largely relate to mining and extractive metallurgy. The inception and nature of the first smelting technologies of copper and tin in Southeast Asia, the Middle East, Europe and Africa, and of zinc in China and iron in Africa, the Middle East and Britain are discussed together with insights into the archaeology and experimental replication of the processes. The authors are drawn from major institutions worldwide, reflecting the international interest the subject now commands. Published in association with the British Museum. For a look inside click here Reviews ...I would recommend this book as a single source for a conservator interested in following recent research in archaeometallurgy. ICON News (May 2008) 33 This is a premier collection of leading researchers, an excellent advertisement for the field of archaeometallurgy, and a worthy tribute to Paul Craddock. The expertise of the authors is complemented by the extremely high standard of design and typography by Archetype Publications, with high-resolution colour printing throughout.
http://archetype.co.uk/publication-details.php?id=37
Art classes expand on the students foundation in understanding and skills in the visual arts in an exploratory manner consistent with the middle school philosophy. Through the Middle School Visual Arts Curriculum, students: - Develop increasingly sophisticated creative strategies, skills, and habits of mind through artistic practices. - Apply design literacy to a wide variety of traditional and new media. - Acquire increasing complex procedural knowledge, skill and craftsmanship in art making while exploring an expanded range of media. - Develop more sophisticated aesthetic judgment that supports the making and understanding of rich meaning in art. - Explore a wide range of notions about the meaning and purpose of visual art. - Form a broader knowledge and understanding of our rich and diverse historical and cultural heritage through art.
https://www.houstonisd.org/domain/50023
The last step examined the reliability, or consistency, of the instrument. This step examines the validity of an instrument, or how well the instrument measures what it is supposed to measure. For example, an instrument was developed to measure mathematics skills. Does the instrument in fact measure mathematics skills, or does it measure something else, perhaps reading ability or the ability to follow directions? It is important to understand that an instrument is not declared valid after one piece of validity evidence. Instead, validation is a process of gathering and evaluating validity evidence. Just because an instrument is face valid does not mean it is construct valid, and just because an instrument is valid in a sample of American youths does not mean that the instrument will be valid in a sample of Nigerian youths. Just like research studies must be evaluated for the quality of the conclusions drawn by critically examining the methodologies such as the sample, instruments, procedures, and data analysis, so too does the validity evidence need to be evaluated to determine whether the evidence does in fact support that the instrument measures what it claims to measure. There is a link between reliability and validity. An instrument must be reliable in order to be valid. For an instrument to be valid, it must consistently give the same score. However, an instrument may be reliable but not valid: it may consistently give the same score, but the score might not reflect a person's actual score on the variable. The measuring tape may consistently say that a woman is 12 inches tall, but that probably is not a valid measure of her height. Below is a visual representation of validity, again using a dart board. Recall that the goal of the game of darts is to throw the arrow into the center of the board. Board A is valid because it is reliable (all of the darts are together) and it hits the mark, meaning that the arrows did what they were supposed to do. Board B is reliable in that all of the darts are together, but it is not valid because the darts are in the corner of the board - not the center. Board C is invalid because it is not reliable. One dart does indeed hit the mark, but the darts are so inconsistent that it does not reliably do what it is supposed to do. There are at least three types of validity evidence: construct validity, criterion validity, and content validity. For a researcher trying to gather validity evidence on an instrument, all three types of validity should be established for the instrument. Each type of validity evidence will be described in turn. Finally, a word will be said about face validity. Construct validity is concerned about whether the instrument measures the appropriate psychological construct. (Recall that another word for construct is variable.) Formally, construct validity is defined as the appropriateness of inferences drawn from test scores regarding an individual's status on the psychological construct of interest. For example, a student gets a high score on a mathematics test. Does this mean that the student really knows a lot about mathematics? Another student gets a low score on the mathematics test. Does this mean that the student really does not know mathematics very well? If the student knows a lot about mathematics but happened to do poorly on the test, then it is likely because the test had low construct validity. In a different example, a participant gets a high score on an assessment of intrinsic motivation. Does this participant really have high intrinsic motivation, meaning that they really enjoy the activity? Consider the following item on a test designed to measure students' vocabulary skills. What is wrong with this item? |In all of the ________________ of packing into a new house, Sandra forgot about washing the baby. | a) Excitement b) Excetmint c) Excitemant d) Excitmint When considering the construct validity of an instrument, there are two things to think about. First, the quality of an instrument can suffer because of construct-irrelevant variance. This means that test scores are influenced by things that are unrelated (aka irrelevant) to the variable that it should be measuring. For example, a test of statistical knowledge that requires complex calculations is likely influenced by construct-irrelevant variance. In addition to measuring statistical knowledge, the test is also measuring calculation ability. A student might understand the statistics, but may have very poor calculation skills. Because the test requires complex calculations, that student will likely fail the test even though she has a good understanding of statistics. This reflects a test that does not have construct validity because there is construct irrelevant (unrelated) variance. Likewise, imagine an instrument to measure intrinsic motivation - enjoyment of the activity. Items that read: "I work hard in maths," "I like the maths teacher," and "I get good grades in maths" all introduce construct-irrelevant variance. The second consideration in construct validity is construct under-representation. This means that a test does not measure important aspects of the construct. For example, a test of academic self efficacy should measure a participant's belief in their ability to do well in school. However, the items on the questionnaire might only measure self efficacy in math and science. This ignores the other important school subjects such as English and social studies. Therefore, this instrument does not represent the entire domain and therefore demonstrates construct under-representation. (This is also called content validity, more of which will be explained later.) If an instrument demonstrates construct under-representation, then it does not demonstrate construct validity. There are three sources of construct validity evidence. There is no one right way to gather construct validity evidence. Construct validity evidence largely comes from thoughtful consideration and a coherent argument in the Instruments section of Chapter 3 about how the instrument adequately relates to the variable that it is intended to measure. To evaluate the construct validity evidence of an instrument, you can report the split-half reliability coefficient to provide evidence of homogeneity, correlations from criterion validity to provide evidence of convergence and theory. You can also report content validity evidence to provide evidence of adequate construct representation. Criterion validity reflects how well an instrument is related to other instruments that measure similar variables. Criterion validity is calculated by correlating an instrument with criterions. A criterion is any other accepted instrument of the variable itself, or instruments of other constructs that are similar in nature. For example, theory predicts that intrinsic motivation should be related to a person's behavior. Therefore, a person who earns a high score on an intrinsic motivation assessment to measure their enjoyment of an activity should engage in the activity when they are not required to. There are three types of criterion validity. First, convergent validity demonstrates that an instrument has high correlations with measures of similar variables. An instrument that measures intrinsic motivation should be closely related to other instruments that measure enjoyment, perseverance, and time spent on the activity. Second, divergent validity means an instrument has low correlations with measures of different variables. Intrinsic motivation should have low correlations with measures of self efficacy, depression, and locus of causality. Finally, predictive validity means that an instrument should have high correlations with criterions in the future. For example, a measure of intelligence should predict future academic performance. As an example of criterion validity, imagine science reasoning essay examination that was developed to admit students into a science course at the university. Criterion validity for this new science essay exam would consist of the following: Therefore, to provide evidence of criterion validity, administer the instrument with other instruments measuring variables that are similar (and are predicted to have high correlations) and other instruments measuring variables that are different (and are predicted to have low correlations). The same participants should complete all instruments, and then calculate the correlations between assessments. For evidence of predictive validity, give a sample the instrument at Time 1. Then wait for time to pass (probably at least a year) and give the exact same sample an instrument of a variable that your instrument should predict. Then calculate the correlation between your instrument and the predictive criterion. Content validity reflects whether the items on the instrument adequately covers the entire content that it should cover. Formally defined, content validity consists of sampling the entire domain of the construct that it was designed to measure. This is best understood in terms of a school examination. Classroom examinations should reflect the content that was taught in class. To be content valid, the amount of items on a test should be proportional to the amount of time the teacher spent covering that topic. For example, in a math class, the teacher spent this much time on each topic: In other words, the teachers spent almost half of the class time on addition (the largest block of the circle). Then about 1/4 of the time was spent on subtraction, followed by a bit of time on multiplication. Practically no time was dedicated to division. The questions on the examination should reflect this division of time spent on each concept: about half of the items should be on addition, about 1/4 on subtraction, a few on multiplication, and practically none on division. However, the coverage of items on the exam looked like this: This exam does not demonstrate content validity. There were just as many items about division on the exam as there were items on addition! This is not fair to the students because the exam does not reflect the content validity of the course content. The chart for the number of items on the exam should be almost identical to the chart for the amount of time spent on the topic in class. Typically, the content validity of an instrument should only be evaluated for academic achievement tests. To assess the content validity of an instrument, gather a panel of judges who are an expert in the variable of interest. Then give the judges a table of specifications of the amount of content covered in the class. How much time is spent in class for each topic? Then give the judges the instrument and an evaluation sheet. The judges should evaluate whether the proportion of content covered on the examination matches the proportion of content in the domain. Face validity addresses whether the instrument appears to measure what it is supposed to measure. To assess face validity, ask test users and test takers to evaluate whether the test appears to measure the variable of interest. However, face validity is rarely of interest to researchers. In fact, it is sometimes possible that an instrument should not demonstrate face validity. Imagine a test developed to measure honesty. Would it be wise for the participants to know that they were being assessed on their honesty? If the participants knew that, then the liars would lie on their responses to try to appear honest. In this case, face validity is actually quite damaging to the purpose of the instrument! The only reason why face validity may be of interest is to instill confidence in test takers that the test is worthwhile. For example, students need to believe that an examination is actually worth the time and effort necessary to complete it. If the students feel that an instrument is not face valid, they might not put forth time and effort, resulting in high error in their responses. In conclusion, face validity is NOT a consideration for educational researchers. Face validity CANNOT be used as evidence to determine the actual validity of a test. The best way to determine that the instruments used in a research study are both reliable and valid is to use an instrument that another researcher has developed and validated. This will assist you in three ways:
http://korbedpsych.com/R09eValidity.html
Chemicals can contribute significant value to products; however, they require careful management to protect people, animals and the environment. New laws for restricting harmful chemical content come into effect every year worldwide to control potential risks; existing laws are constantly evolving to keep pace with new information and scientific advancements. As a result, there are a wide variety of chemical regulations manufacturers must address. Below is an overview of some common chemical regulations. - Restriction of Hazardous Substances (RoHS): A European directive that bans the following from electric products: mercury, lead, cadmium, hexavalent Chromium, polybrominated biphenyl, and polybrominated diphenyl ethers. RoHS 2, or RoHS recast, which provides improved guidelines and expands the scope of products covered, is now a CE marking directive, meaning compliance is required to place a CE marking on a product. - Registration, Evaluation, Authorization and Restriction ofCHemicals (REACH): A European directive meant to hold companies accountable for understanding and managing risk associated with chemicals. The Substances of Very High Concern (SVHC) list contains 161 chemicals; if a product contains any of the listed chemicals above 0.1 percent wt/wt, it must be communicated. - The European Union's Waste Electronics and Electrical Equipment (WEEE) Directive: Places the obligation of recycling electrical and electronic equipment products (including collection, treatment, and environmentally friendly disposal) on manufacturers. Failure to comply with the WEEE Directive places manufacturers at risk for prosecution and inability to place products in the EU. - Cal Prop 65: The California Office of Environmental Health Hazard Assessment publishes a continuously updated list of chemicals "known to the state to cause cancer or reproductive toxicity" under the Safe Drinking Water and Toxic Enforcement Act of 1986, also known as Proposition 65. Manufacturers that produce consumer products containing chemicals on the list must provide a warning to that the product contains said chemicals, if exposures are high enough to pose a significant risk. - Conflict Minerals Act: While this is not a toxic chemical regulation, it still is one that is designed to protect people and should be followed like restricted substance regulations. As part of the Dodd-Frank Act, the SEC requires all U.S. publically traded companies to disclose (through SEC filings) whether they source conflict minerals: tin, tantalum, tungsten and/or gold from the Democratic Republic of Congo or the nine surrounding countries, mined to fund local militias. Private companies in a public company's supply chain will be indirectly impacted, as customers request information on these minerals for their SEC filing. There are several steps manufacturers can take to help establish compliance with chemical regulations: - Establish a restricted chemical management program to help ensure organizational knowledge and responsibilities at all levels of a company. Everyone must be aware of their role in limiting the use of restricted chemicals. - Document compliance, a simple solution that requires attention to many details. Make sure you are getting proper and valid documentation. Consider ongoing changes to directives. Base technical support on data, not just statements, to determine whether documents are valid, contain the proper information and are up to date with the current standards. - Conduct risk assessment and due diligence, looking at the type of materials being supplied, the suppliers themselves and potential exposure. Take precautions to make sure you are getting compliant material, such as requesting full lab data on batches, self-inspection/testing of incoming products and/or supplier audits. The exposure of having a product found to be environmentally unfriendly is too great to ignore. Implementing a chemical management program, documenting compliance and conducting risk assessments as you develop products will go a long way in mitigating issues. Proper assessment of the intended use and markets for your products and a thorough knowledge of exclusions and exemptions can also provide a benefit in achieving compliance to chemical regulations. Finding experts in the space to partner with is a great option that could ultimately save time and money. As the Senior Director of Chemical Services for Intertek, Andy Gbur works with manufacturers to insure product compliance to the ever changing landscape of restricted chemical regulations across the globe. He and his staff have been associated with the HVAC/R industry via AHSRAE and AHRI technical committees for the past 22 years, specifically within the chemical and compliance realm. He holds a B.A. in Chemistry from The Ohio State University and is based in Columbus, Ohio. Tags: 2015 | Andy Gbur | Chemicals Andy Gbur,
https://www.intertek.com/blog/2015-08-10-chemical-regs/
The seemingly never ending change to pension legislation was exacerbated by last week’s Autumn Statement. The Government’s focus on containing the costs of pension tax relief was highlighted by a two- pronged attack on the annual amount of future relievable pension savings and a further reduction on the lifetime allowance. It is good news from an industry perspective that these changes will not come into effect until the start of the 2014/15 tax year, allowing clients and advisers to review current circumstances and have time to act appropriately. However the wider message being delivered to UK savers creates further uncertainty as to longer term use of significant pension savings as part of a retirement income strategy. In looking at the detail of the announcements, there are lots of planning opportunities that will exist for the right clients over the next 15 months or so and provide significant opportunities for advice in the post RDR world for advisers. Here is a summary of some of these key opportunities. Annual Allowance The reduction in the annual allowance to £40,000 will not happen until the start of the 2014/15 tax year. Even at that point, the current £50,000 annual allowance will remain available, where carry forward of unused annual allowances is being used as a funding exercise for input periods ending in the tax years 2011/12; 2012/13 and 2013/14. Whilst this will give investors opportunities over a number of years to continue to fund contributions at largely existing levels there are some shorter-term planning opportunities to use the current regime sooner rather than later. Tax Rates Although not confirmed in the Autumn statement, the Chancellor had previously signposted a possible reduction in additional rate tax from 50 per cent to 45 per cent from the start of the 2013/14 tax year. Additional rate taxpayers should therefore consider making contributions this tax year to the extent of their tax liability, as a means of reducing the net cost of the pension investment. For others, the ability to use the combined allowances to reduce their adjusted net income below £100,000 will be important. In doing so, they will be able to regain their full personal allowance for this and/ or the next tax year with an effective marginal rate relief of 60 per cent on the element of contribution that reduces adjusted net income from £116,210 to £100,000. Life Time Allowance With the lifetime allowance being reduced from £1.5m to £1.25m from the start of the 2014/2015 tax year and the option to apply for fixed protection on of the £1.5m allowance, it is important for investors to use their current annual allowance and utilise any carry forward of earlier unused allowances. There may be an opportunity through the use of pension input period planning to fund the 2014/15 annual allowance before the end of next tax year and then register for the new form of fixed protection. Fixed Protection Mention of fixed protection brings me onto the other part of the attack on the level of tax relief available for pension savers – that of the reduction in the lifetime allowance from the start of the 2014/15 tax year. This further 16.67 per cent reduction in the lifetime allowance, that back in 2010/11 was understood would not be reduced, will take more clients out of the registered pension scheme market in terms of future accrual beyond the start of the 2014/15 tax year. This not only affects clients with existing large pension scheme values, but clients with longer term views as to when they may be looking to access their existing pension savings. Clients will have to consider what levels of future pension savings that may be needed to ensure they keep within the reduced lifetime allowance. This will create lots of advice issues that need to be included in this area: - Investors may wish to change investment strategies for their money purchase pension savings to reduce risk in their portfolio. Whilst this may have the disadvantage of limiting potential future growth, the upside is that they can still continue to benefit from immediate tax relief on further funding using registered pension savings and keep on target to the future lifetime allowance - If they decide to ‘opt-out ‘ of registered pension scheme savings, what other strategies for continuing to build retirement income will need to be considered - Where individuals are currently receiving employer contributions and decide to elect for ‘fixed protection 2’ at the end of 2013/14 tax year how, if at all, will an employer be compensating future loss of pension contributions. Personalised Protection Option To potentially complicate matters further, the Government will also be consulting on a new form of protection, the personalised protection option. Under this new option individuals will be able to apply for a personal lifetime allowance of between £1.25m and £1.5m subject to a maximum of the value of their benefits on 5 April 2014. There will be no restriction on further contributions and benefit accruals that will be subject to normal tax reliefs, but the lifetime allowance charge will apply to any excess over the personal limit when benefits are crystallised. As an observation, are these changes simply a means for the Government to redistribute the future cost of pension tax relief to take account of the impact of auto-enrolment? The increasing number of individuals who will contribute to pension arrangements over the next few years are mostly clients who will never be threatened by the proposed annual allowance or lifetime allowance changes. The opportunities for advice and wider financial planning around these announcements are significant and action sooner rather than later for advisers in identifying those clients who could be impacted should be the call to action.
https://www.moneymarketing.co.uk/autumn-statement-pension-planning-opportunities/
About Westminster Village - West Lafayette Westminster Village - West Lafayette is a 72 unit housing community for elderly people situated in West Lafayette, Indiana. They provide senior housing in a well-managed and engaging setting. The zip code of 47906 which this community is located in has a dense population, with around 66,972 people. It is a generally middle income area, with a median household income of $35,806. They are centrally located, with retail shopping, religious services, and health care facilities all within a close distance. They are located only 1.3 miles from Wabash Valley Hospital, there are 15 drugstores within 1 mile of the community, and there are 46 churches within four miles, which include Temple Israel, Federated Church, Blessed Sacrament Church, and Upper Room Christian Fllwshp. Westminster Village - West Lafayette offers assisted living, independent living, nursing home care, and Alzheimer's care. The facility is a good option for those who need help with routine activities but who also wish to preserve some of their independence. Also, they can provide for older people who are independent and self-sufficient but want a worry-free life with services like on site maintenance, house keeping, and social activities. In addition, they can service those who are seriously infirmed and need help with routine activities and who must have frequent access to medical services. Lastly, they can assist those at any level of dementia or Alzheimer's Disease who require assistance with routine activities and monitoring to prevent wandering. This community has many amenities and services to offer their residents. For example, they provide a selection of facility amenities that include landscaped grounds, outdoor walking trails, an on-site convenience store, a book collection, and a fitness center. Additionally, they feature a myriad of medical services such as medication support, speech therapy, pain management, foot care services, and dental care . Finally, they feature lots of recreational activities like television and movie nights, daily exercise routines, spiritual/religious activities, arts and crafts projects, and yoga. Westminster Village - West Lafayette has been commissioned by Medicare for 37 years. They obtained an aggregate score of 5/5 stars in the latest report published by Medicare. This rating is based on a collective criterion of overall quality, health reviews, and staffing evaluations. They had no total penalties levied, no complaints made, no payment denials, no fines levied, and 2 deficiencies recorded during this period. Nearby Cities Get Pricing and Availability *First Name: *Last Name: *Email: *Phone: We value your privacy. By clicking "Request Free Info," you consent to our privacy policy and to receiving autodialed calls from our marketing partners at the number above. Your consent is not a condition of receiving services and may be revoked at any time. Need Help? 1-888-305-1171 Request Pricing and Availability
Fig. 1. This image shows a large plume of methane-rich water, visible as a dark cloud, extending from the bottom hundreds of meters up into the water column. At the base of the thermocline (a water layer where temperature changes with depth), some of the gas bubbles are trapped forming a horizontal layer of methane-rich water in the upper water column. Click image for larger view and image credit. Fig. 2. Kazumi Shibata, a Woods Hole Oceanographic Institute technician, directs the winch operator during deployment of the CTD (a rosette instrument that measures conductivity, temperature, and depth). The rosette contains water sampling bottles (the long gray bottles) and a physical/chemical sensor array, which is mounted horizontally along the bottom of the frame). Click image for larger view and image credit. Sniffing for Methane May 23, 2006 Mandy Joye University of Georgia 27° 38.85 N 088° 21.72 W The Expedition to the Deep Slope focuses on the study of seep-associated fauna and the sediments where the fauna live, but we are also interested in the following questions: What happens to the seep-derived material – both oil and gas – that escapes the benthos (bottom) and reaches the overlying water column? Do water-column microorganisms convert methane to biomass and reduce the flux of this important greenhouse gas to the atmosphere? Methane consuming microorganisms can be thought of as an effective biological filter (a "biofilter") that prevents methane from reaching the atmosphere. The efficiency of the methane biofilter around seeps, and possibly in the water column, is not presently known. To study methane dynamics in the water column over seeps, we use a variety of techniques. In shallow water (less than 1,000 m), we can use chirp sonar to visualize gas plumes in the water column (fig 1). The plumes are visible using acoustic methods because sound travels differently through water containing gas bubbles. To describe the structure of the water column and decide where we should collect water samples for analysis, we conduct a hydrocast. A hydrocast entails using a system of remotely controlled water-sampling bottles, called Niskin bottles, and a suite of chemical sensors. The bottles and sensors are mounted on a rosette that is lowered through the water column by winch and a conducting cable (fig 2). As the chemical sensors descend through the water column, they report back to a computer on board the ship, allowing us to visualize the physical and chemical conditions of the water at each depth and select depths for water sampling. This image (fig 3) shows a typical depth-profile of salinity and temperature, collected at the Atwater Valley 340 study site at a depth of 2,200 m. As the rosette is slowly brought back to the surface, water samples are collected by remotely triggering the Niskin bottles to close. With the samples on board, we can use sensitive laboratory techniques to analyze methane concentrations and the rate at which the microorganisms are using the methane in the water (fig 4). With these data, we can determine the efficiency of the methane biofilter. We also measure a suite of additional chemical parameters, like oxygen and nutrient concentrations, with the hope of learning more about what regulates methane oxidation in the water above cold seeps.So far on this cruise, we have quantified supersaturated concentrations of methane in the bottom waters and, surprisingly, throughout the water column. A very unusual, thick layer of low oxygen water has also been noted at mid-water depths (about 300 to 1,000 m) at all of the sites we’ve examined so far. At this point, we still have many more questions than answers about this strange mid-water anomaly. Hopefully, we’ll have more answers to share before the cruise ends! Sign up for the Ocean Explorer E-mail Update List.
https://oceanexplorer.noaa.gov/explorations/06mexico/logs/may23/may23.html
Home > About LSCM > Profile The Hong Kong R&D Centre for Logistics and Supply Chain Management Enabling Technologies (LSCM R&D Centre) was founded in 2006 with funding from the Innovation and Technology Fund of the HKSAR Government. Since its inception, the LSCM R&D Centre’s mission has been to foster the development of core competencies in logistics and supply chain related technologies and to facilitate the adoption of these technologies by industries in Hong Kong and Mainland China. The Centre is hosted by three leading universities in Hong Kong, namely the University of Hong Kong, the Chinese University of Hong Kong, and the Hong Kong University of Science and Technology. The establishment of the Centre marks the realisation of the concerted effort and enthusiasm on the part of the government, industry, academia and research institutes. Vision - To be globally-recognised as a leading centre of excellence in logistics and supply chain management research and development - To develop niche technologies that differentiate and achieve excellence Mission - Conduct R&D activities to develop core technological competencies in the logistics and supply chain industries - Facilitate the adoption of these technologies by industries in Hong Kong / Mainland China in order to enhance competitiveness - Focus on deployment in specific industries and industry segments in Hong Kong in order to make an impact Service The Centre has been commissioned to be a one-stop resource for applied research, technology transfer and commercialisation, by undertaking the following roles and functions: - Conduct industry-oriented researches - Provide consulting and market intelligence services - Provide a platform for business matching and technology transfer - Facilitate intellectual property commercialisation What Difference Does LSCM Make? To the industry: - LSCM’s technology development is focused on niche applications but target to serve a broad spectrum of users To the academia: - LSCM aims at closer cooperation to conduct market-driven researches based on each university/research institute’s expertise and technological strengths To the public sector:
http://www.lscm.hk/eng/channel.php?channel=company-profile
At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We're committed to fostering an environment for every teammate that's welcoming, respectful and inclusive, with great opportunity for professional growth. Find your future with us. This position is for a systems engineer (SE) in the Systems Engineering, Integration and Test (SEIT) of Boeing India Engineering, to support an Indian Navy (IN) team of technicians actively piloting autonomous robotic vehicles in India. As member of SEIT team, the individual will be a technical systems engineering service professional supporting our Wave Glider operations at Naval Base Porbandar and reporting to our Wave Glider Operations Center at California. Position is based in Porbandar, Gujarat, India. Primary Responsibilities: - Apply health, safety, security, and environmental (HSSE) best practices in all operational work. - Provide troubleshooting / oversight assistance (through reach-back support to Liquid Robotics (LR Boeing in the USA if required) to the IN in their maintenance and operation of Wave Gliders at the Porbandar Naval Base. - Maintain inventory of spares being supplied for warranty and subsequent Annual Maintenance Contracts (AMC) as well as assist in the processing of warranty claims between LR and IN. - Launch, pilot, recover, service, troubleshoot and repair Wave Gliders and related instruments and sensors after appropriate training by OEM - Be recognized as Wave Glider technology champion, with exemplary knowledge of system configurations, operations, troubleshooting, and repair based on the bench or in the field. - Direct and supervise crew and technicians in a leadership capacity during local and remote field operations. - Plan, oversee, execute and report on field operation activities such as on in-water testing and operation of Wave Glider systems and related instruments and sensors. This includes coordinating all aspects of field operations including vessels of opportunity, facilities, and logistics in remote locations. - Conduct and record preventative maintenance and configuration management. - Exhibit competence in reading and interpreting schematics and engineering control documentation to core functional level. - Function as the escalation point of contact for external and internal customer contacts who demonstrates competence, knowledge and confidence in the ability of the systems to perform their - Train others to operate and maintain Wave Gliders and related instruments and sensors. - Duties for this role include but are not limited to: organizing and overseeing technical field operations, support in IN launch and recovery of Wave Gliders and associated equipment from IN vessels, interacting with vessel staff and marine operations crews which maintain, troubleshoot and repair Wave Gliders. Skills/Competencies Required: - At least 7-10 years' full-time service in the Indian Navy, including experience in maintaining - ASW sensor suite onboard ships and submarines - Strong customer service orientation (strives for best customer experience, and operational - The Systems Engineer has significant marine engineering and technology experience working with a team of engineers and technicians. - This individual qualifies as an expert Wave Glider engineer in support of operational and engineering testing, customer deployments and customer training. - This individual has experience in a project or program management role and has experience operating in an independent capacity capable of complex problem solving - Excellent communication skills and attention to detail (written and verbal). - Ability to work flexible schedules (non-standard work shifts) and work alone for extended periods. - Work effectively with all levels of employees cross-functionally, as well as external parties. - Recognize and execute tasks (often unstructured) requiring new perspectives and creative approaches. - Take initiative with limited supervision and direction to ensure business objectives are met. Qualification/Education and Experience Required: - 7-10 years in the Indian Navy - B. Tech/Tech Qualifications acquired while working in Indian Navy in engineering, marine science/technology or minimum 12yrs in a related field. - Significant experience in maritime operations including deck operations while at-sea, equipment service, launch and recovery of oceanographic equipment - Highly technical background and proven ability to troubleshoot and repair complex electromechanical systems. - Experience with bench and field servicing of pressure vessels, waterproof connectors, oceanographic equipment, instruments and sensors. - Working knowledge of AC/DC power systems, computer programming (e.g. LINUX), terminals & - Excellent written and verbal communication skills. - Proven ability to operate as a leader and a team player. Preferred - Experience with autonomous vehicles - Experience with photo and video documentation - Basic machine shop and welding operations, mechanical aptitude - BOSIET/HUET or equivalent certified - SCUBA Certified - First Aid/O2 Certified Basic Qualifications for Consideration Preferably Retired Technical / Sailors from the Indian Navy with the following qualifications Military Navy: Electrical/Marine (B Tech) or with 10-12 years' full-time service in the Indian Navy, including experience in maintaining ASW sensor suite onboard ships and submarines Preferably having worked on Sonars, LOFAR Arrays and C4I2 systems Liquid Robotics designs and manufactures Wave Gliders, the world's first wave and solar powered autonomous ocean robots. With partners, we address challenges facing defense, Oil & Gas, commercial and science customers by making ocean data collections and communications easier safer and in real- time. Liquid Robotics was acquired by Boeing in December of 2016 and operates as an independent nonintegrated subsidiary. All information provided will be checked and may be verified. This requisition is for an international, locally hired position. Candidates must be legally authorized to work in India. Boeing will not seek immigration and labor sponsorship for any applicants; this is the responsibility of the job candidate. Benefits and pay are determined at the local level and are not part of Boeing U.S.-based payroll. RELOCATION BENEFITS IF INDICATED ARE LIMITED TO IN-COUNTRY MOVES AND ARE NOT AVAILABLE FOR OVERSEAS RELOCATION. THERE IS NO EXPATRIATE PACKAGE ASSOCIATED WITH THIS POSITION. Vaccination Requirements: Boeing is implementing new requirements for employees to be fully vaccinated from COVID-19 or have an approved reasonable accommodation based on local legislation in several countries including U.S.-based employees. Please refer here for current vaccination and/or reasonable accommodation requirements, and timelines based on location. Equal Opportunity Employer: Boeing is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national origin, gender, sexual orientation, gender identity, age, physical or mental disability, genetic factors, military/veteran status or other characteristics protected by law.
https://fairygodboss.com/jobs/boeing/engineering-customer-support-service-technician-b5a047b645bf9b73b6f67e77b3f5dc2a
How Our Foundation is Using an Equity Framework—and Equity Data—to Guide Our Investments For 95 years, the Community Foundation for Greater Buffalo has been committed to realizing its vision of a vibrant, inclusive region with opportunity for all. Our foundation makes the most of its clients’ generosity by bringing together seemingly different groups to develop collaborative solutions that realize this vision in Western New York. Now, more than ever, there is momentum to take on the region’s longstanding challenges and reverse the decline of the past decades. One of our key community goals is to improve racial equity. Approximately 90 percent of all board-directed resources support communities of color. While racial equity stands on its own, it is also a critical factor in addressing our goal to improve educational achievement for low-income students. Other goals include enhancing and leveraging significant natural resources (using an environmental justice perspective), and strengthening the region as a center for architecture, arts and culture by ensuring that all children have access to consistent arts instruction. Key Equity Data Points Driving Our Work Data that is disaggregated by race and ethnicity plays an important role in grounding our work and, in combination with storytelling, helps to inform our key initiatives. Powerful data points that drive our portfolio include the following: - The Buffalo Niagara region ranks 98th out of 100 metros in black/white equity and 89th in Latino/white equity (from the U.S. Census) - People of color are disproportionately clustered in urban centers and Buffalo is the third poorest city in the U.S. (also from the U.S. Census) - Population growth in the region is driven mainly by foreign-born people of color, recent immigrants to America (from City Vitals 2.0) Our foundation selected these three data points very intentionally to make the case for increasing racial and ethnic equity, especially as a driver for economic growth. As communities of color grow as a share of the population, it is even more urgent to dismantle racial barriers and ensure all of our residents can access the educational and economic opportunities they need to contribute to the region’s revitalization, resilience, and prosperity. Our Racial Equity Framework We also adopted a framework introduced by PolicyLink to close the racial wealth gap through seven strategies: 1) Fortify the cradle-to-career pipeline 2) Reconnect the long-term unemployed 3) Grow businesses owned by people of color 4) Build power among a workforce comprised of people of color 5) Open up access to economic opportunities in high-growth sectors 6) Build wealth in communities of color 7) Leverage urban resurgence to grow income and wealth We adopted this framework because it articulates the community-level strategies needed to support a stronger regional economy that decreases our racial disparities and increases the equity dividend: the benefits to our whole region that will come from expanding opportunity for all. The framework also gave our board a new way to evaluate their work and investments. Investing in a Data-Driven Equity Strategy: Say Yes Buffalo Equity data plays a major role in several of foundation-supported initiatives that bring together stakeholders across multiple sectors to advance the seven strategies. One of the Community Foundation’s most powerful data-driven cross-sector partnerships is Say Yes Buffalo, which is aligned with the PolicyLink strategy to fortify the cradle-to-career pipeline. “Recognizing the clear link between future economic prosperity and educational achievement, the Foundation committed to launching Say Yes Buffalo in late 2011,” said Clotilde Perez-Bode Dedecker, President and CEO of the Community Foundation for Greater Buffalo. “Say Yes Buffalo is an unprecedented, cross-sector partnership, focused on increasing post-secondary completion rates for urban youth.” While the driving force behind Say Yes Buffalo is a universal scholarship program offered to students in the Buffalo Public Schools, financial aid for college is just one component of the effort, which seeks to remove all barriers to educational success. To the academic, health and behavioral challenges our students face, Say Yes Buffalo and its partners are putting people and programs run by respected community-based organizations directly into the Buffalo Public School buildings. For example, in 2014 with the help of Erie County and the Community Foundation for Greater Buffalo, 19 schools now have an on-site mental health clinic to provide students and families easy access to social and emotional supports. To date, Say Yes Buffalo has provided scholarships for over 1,500 high school students and after just the first year, the number of Buffalo Public High School graduates enrolling in two and four-year institutions increased by 9-percentage points.
https://nationalequityatlas.org/data-in-action/buffalo-commfound
tealbook series ten coves 73m wiggersventurebeat One of the most important elements of a balanced diet is fruits and vegetables. Children should be provided with a wide range of different fruits and vegetables. Vegetables should be washed well and the skin should be left on fruit and vegetables. The salt content of these foods should be kept low. Children must also drink adequate water. If they are dehydrated, they will feel grumpy and tired, so they should drink at least six to eight cups of water a day. They should also limit their intake of fizzy drinks and sugary beverages economictimes. In addition, children should consume three to five ounces of grains daily, with half being whole grains. Each meal should have at least one serving of fruit or vegetable. The recommended daily intake of fruits and vegetables is one to one and a half cups. Vegetables should be served with each meal, and young children should be given a variety of vegetables and fruits. Children at school need a healthy diet to maintain a healthy weight and improve their academic performance. Unfortunately, a number of children in the U.S. do not eat enough nutrients to grow to their full potential. A lack of vitamins, minerals, and fiber can lead to malnutrition or obesity. Children with poor nutrition can have difficulty learning, suffer from low energy, and have weak bones mytoptweets. Fruits and vegetables are important for a child’s growth and development, as they are full of vitamins and minerals. In addition to fruit and vegetables, kids need plenty of lean meat and low-fat dairy products, as well as low-fat yogurt. They also need omega-3 fatty acids . Fruits and vegetables are a good source of Vitamin C, which is essential for iron absorption and fighting infection and wound healing. Fresh fruit is the best option xfire, but frozen or canned fruits are also available. Choosing fruit and vegetables with different colours helps prevent nutrient deficiencies. Ideally, children should have five or more servings of fruits and vegetables per day. In addition to fruits and vegetables, children should eat at least two servings of dairy foods each day. They should also be given a limited amount of treats. It is also important to encourage regular family mealtimes, which not only promote good nutrition, but also promote proper table manners. Moreover, eating together can help foster language development techlognews.com. Effects of nutrition on health and fitness Whether you’re an athlete or just looking to keep fit, the right nutrition can enhance your performance. Proper nutrition provides the energy your body needs to perform daily activities, and it’s important to balance it with exercise to maintain your optimal health. Exercise burns calories and builds muscles, while nutrition provides energy and restores your energy levels. Carbohydrates provide the best energy, so focus on eating whole grains to maximize the amount of carbohydrates you get and avoid empty calories. Eating plenty of fruits and vegetables is essential for overall health and fitness. These foods are packed with vitamins and minerals and are low in calories. In fact, the United States Department of Agriculture recommends that you eat half a plate of fruit and vegetables with every meal. In addition, eat as many different kinds of fruits and vegetables as you can so that you get the full spectrum of nutrients. Moreover, you can also stock up on dried fruits and raw vegetables and bring them with you on workout days. The education sessions included maternal nutrition, as well as antenatal care and HIV counseling. They included five to ten minutes of teaching each participant. The midwives also included one-on-one sessions with women, depending on their nutrition status. While the midwives did not have to spend a whole session with each woman, they did take the time to discuss nutrition supplementation. During these five to ten-minute sessions, midwives would talk with the woman about iron and folic acid supplementation, and the need for prenatal care Newstodaysworld.com. The children studied were six to eleven years old and attending public primary schools. About 54% of the children studied were girls. The age group with the highest deficiency was nine-year-olds. The study participants were anthropometrically measured and completed questionnaires about their eating habits, meal preparation, and nutritional knowledge newstodaysworld24.com. Finally The amount of dietary fat that a child consumes also influences the amount of SFAs in their body. Children in both groups consumed too much poultry meat, cold cuts, and sweets. The oldest children had the highest PUFA intake, but also consumed fewer sweets and fish than their younger counterparts.
https://cocospy.info/tealbook-series-ten-coves-73m-wiggersventurebeat/
Your drone's rotors / propellers are built to be robust and flexible to avoid hurting people or damaging other items. Thus, bending will appear after various bumps. Check to make sure the propellers are properly installed before a flight. Without a GPS signal, the risk of accidents increases If you fly your UAV indoors, you will lack the GPS signal. For this reason, it is recommended that you always fly in open areas, as far away from tall buildings as possible. Incorrectly set compasses and return-to-home points are one of the biggest causes of drone crashes. Drone compasses can be intercepted by any magnetic and radio frequency (RF) source. Avoid flying in an environment with high electromagnetic interference, close to high-voltage power lines and mobile phone towers, as well as being too close to magnets such as car speakers during the transfer of unmanned aerial vehicles. Check ports before flight Always make sure your cables are well connected and carefully unplugged before flying to keep the ports in good condition.
https://alurmedya.com/farmer-shoots-drone-with-potato-from-the-sky=10
GPS Interferometric Reflectometry (GPS-IR), a passive microwave remote sensing technique utilizing GPS signal as a source of opportunity, characterizes the Earth's surface through a bistatic radar configuration. The key idea of GPS-IR is utilizing a ground-based antenna to coherently receive the direct, or line-of-sight (LOS), signal and the Earth's surface reflected signal simultaneously. The direct and reflected signals create an interference pattern of the Signal-to-Noise Ratio (SNR), which contains the information about the Earth's surface environment. GPS-IR has proven its utility in a variety of environmental remote sensing applications, including the measurements of near-surface soil moisture, coastal sea level, snow depth and snow water equivalent, and vegetation biophysical parameters. A major approach of the GPS-IR technique is using the SNR data provided by the global network of the geodetic GPS stations deployed for tectonic and surveying applications. The geodetic GPS networks provide wide spatial coverage and have no additional cost for this capability expansion. However, the geodetic GPS instruments have intrinsic limitations: the geodetic-quality GPS antennas are designed to suppress the reflected signals, which is counter to the requirement of GPS-IR. As a result, it is desirable to refine and optimize the instrument and realize the full potential of the GPS-IR technique. This dissertation first analyzes the signal characteristics of four available polarizations of the GPS signal, and then discusses how these characteristics are related to and can be used for remote sensing applications of GPS-IR. Two types of antennas, a half-wavelength dipole antenna and a patch antenna, are proposed and fabricated to utilize the desired polarizations. Four field experiments are conducted to assess the feasibility of the design criteria and the performance of the proposed antennas. Three experiments are focused on snow depth measurement. The Table Mountain experiment data shows a more distinct interference pattern of SNR and yields a more precise snow depth retrieval. The Marshall experiment data reveals the effect of the underlying soil medium on snow depth retrievals, which benefits from the improved sensitivity of the dipole antenna to snow depth change. The experimental data of the third snow experiment conducted at a mountain-top location shows that a variant surface tilt angle can result in considerable retrieval errors of snow depth. An algorithm utilizing the estimated surface tilt angle is proposed to calibrate the retrieved snow depth. The calibration algorithm significantly improves the accuracy and precision of snow depth retrievals. The last experiment provides an opportunity to evaluate the dipole antenna as applied to the measurements of vegetation biophysical parameters and near-surface soil moisture. The normalized SNR amplitude shows a negatively linear relationship with in situ measurements of vegetation water content over a range of 0-6 kg/m2, which is much greater than the range from the geodetic antenna data (0-1 kg/m2). The normalized SNR amplitude also shows a positive linear relationship with the near-surface soil moisture measurements, indicating its potential as a soil moisture sensor. Chen, Qiang, "Optimization of GPS Interferometric Reflectometry for Remote Sensing" (2016). Aerospace Engineering Sciences Graduate Theses & Dissertations. 133.
https://scholar.colorado.edu/asen_gradetds/133/
Can Siteimprove spellcheck Chinese, Japanese and other languages that use syllabic writing systems? By Guðrún Gústafsdóttir Unfortunately Siteimprove cannot check "symbol" languages such as Chinese, Japanese or Korean. This article is intended to explain to why this is. A word in Chinese usually consists of 1-3 symbols. Words and phrases that belong to each other are mostly written in one line without spaces because they are not necessary in the same way that they are necessary in English, French, Danish or German. So you may have a line of symbols that look like one word with 8 letters, but it might actually be a sentence that could be anything from 3-8 words. Chinese symbols that appear on websites are mostly written on Roman alphabet keyboards using what is called the Pinyin input method. Pinyin is the way the symbols are written with roman letters. For example "你好" is a Chinese greeting (Hello) that would be spelled like this in roman letters: "nihao". There are several applications that make it fairly easy to write symbols that way. A user would write "nihao" into his pinyin input application, would receive a few different possible symbols to choose from, needs to choose the correct symbol(s) and to enter them into a document or content editor. The potential problem arises when you do not use the correct symbol for what you actually want to say, because then the sentence may either change its meaning or lose its meaning entirely. When it comes to proofreading the Chinese language, it is not the symbols themselves that would be useful to check, but rather if the chosen symbols match the intended meaning of the sentence. Unfortunately, an automated way to proofread the meaning of symbols in sentences is not possible at this time. This type of proofreading method would require artificial intelligence that actually understands the meaning of what a content editor is trying to say. So far this is only possible with human proofreaders. Siteimprove is currently not able to spellcheck Chinese, Japanese or other "symbol" languages.
https://support.siteimprove.com/hc/en-gb/articles/114094155091
Introduction {#Sec1} ============ Metabolites are the final products of cellular regulation, and their types as well as quantities are deemed the final response of a biological system to changes in genes or the environment. It has been estimated that there are more than 200,000 metabolites in the plant kingdom, including primary metabolites used to maintain plant life and secondary metabolites used to protect plants against biotic and abiotic stress. The metabolites in plants play an important role in their growth, and the composition of different organisms directly correlates with their properties. In most Asian countries, many plants, which are usually called medicinal herbs, are always used to cure certain diseases due to their treatment efficacy for many diseases, and the metabolites are responsible for the curative effects. Usually, the metabolites in medicinal herbs belonging to different genera are greatly different, and common metabolites are rare. However, medicinal herbs in the same genus always have great similarity not only in morphology and gene DNA sequences but also in their chemical metabolites because of their similar metabolic pathways. This can easily lead to confusion in their clinical use and raise questions regarding the clinical safety of medications. It is well known that the formation and distribution of secondary metabolites are always species specific, and the metabolites in medicinal herbs belonging to different genera are always greatly different. However, the metabolites in medicinal herbs belonging to the same genus are greatly similar, and each medicinal herb species contains its own specific chemical metabolites, which can be selected as specific biomarkers to differentiate a particular species from other similar herbs. Until now, the selection of a specific biomarker from hundreds of metabolites in medicinal herbs has been a crucial problem. Some researchers have compared the metabolite profiles of crude extracts of similar medicinal herbs in a non-targeted manner using the premise of desirable chromatographic separation, and the specific metabolites were intuitively chosen and then analyzed by mass spectrometry (MS)^[@CR1]^ or nuclear magnetic resonance (NMR)^[@CR2]^. With the help of MS^[@CR3],\ [@CR4]^ and tandem mass spectrometry (MS/MS) spectral databases^[@CR5]--[@CR8]^ and NMR chemical shift databases^[@CR9],\ [@CR10]^, some known and unknown specific metabolites can be identified. However, the estimation of the chemical structures of unknown metabolites in metabolite profile data continues to present challenges^[@CR11]^ because of a lack of reference standards. In fact, the results are not particularly accurate, and the selected specific biomarkers were incomplete. Most of the specific biomarkers have not been analyzed due to samples containing many overlapping signals; in addition, the most intense signals were usually picked out to represent metabolites of interest, and the less intense signals were always neglected. Moreover, whether the selected specific biomarkers are typical cannot be confirmed. Therefore, it is still a great challenge to analyze their metabolite profiles and to select specific biomarkers. In our experiment, we solved this problem using metabolomics technology, which studies the body from a holistic perspective in an extremely duplicable system and now plays a significant role in many biological fields^[@CR12]--[@CR18]^. Especially in the plant field, metabolomics can systematically analyze the overall metabolites and yield specific biomarkers contributing to classification and making the effective screening of crucial specific metabolites a reality. Mass spectrometry (MS)-based metabolomics is well suited for reliably handling high-throughput samples with respect to both technical accuracy and the identification and quantification of low-molecular-weight metabolites. The advantages of MS-based metabolomics are best realized when coupled to liquid chromatography (LC). In particular, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS) has been widely used for metabolomics studies because of its high sensitivity, high accuracy and high resolution, which indicates that even low-response metabolites can be collected and identified. In addition, the high resolution of MS and MS/MS information on metabolites is helpful for metabolite identification. Generally, there is more than one specific biomarker in one herb, and it is inadvisable to use all of the specific biomarkers to differentiate one herb from others due to some reference standards being unavailable or to avoid making the experiment much more complicated. In our experiment, we analyzed the relationships of specific biomarkers using the correlational analysis strategy, and the most representative specific metabolites were selected as the final specific biomarkers. In this study, we use ginseng (*Panax ginseng)* as an example to demonstrate how to screen for specific biomarkers using a metabolomics approach. *Panax ginseng* is well known as the lord or king of herbs and is now widely used not only in Asian countries but also in many western countries. Obviously, medicinal herbs not belonging to the *Panax* genus have hardly any similarity in metabolites, morphology or gene DNA sequence with *Panax ginseng*. Therefore, it is easy to differentiate *Panax ginseng* from them. However, medicinal herbs belonging to the same genus with *Panax ginseng* share great similarity in many aspects, especially in their chemical metabolites because of their similar metabolic pathways. The three most common herbs in *Panax* genus, including *Panax notoginseng*, *Panax quinquefolium* and *Panax japlcus var*, have many metabolites in common with *Panax ginseng*, and even their metabolite profiles are extremely similar. However, these four herbs cannot replace each other in clinical use. To avoid confusion with the other three herbs, the specific biomarkers of *Panax ginseng* were selected from their extremely duplicable metabolite profiles using metabolomics technology. Finally, three metabolites, including chikusetsusaponin IVa (Ch-IVa), ginsenoside Rf and ginsenoside Rc, were selected as the most representative specific biomarkers of *Panax ginseng* via correlational analysis; moreover, they can obviously differentiate *Panax ginseng* from the others. Results and Discussion {#Sec2} ====================== Method validation and metabolite profiling process {#Sec3} -------------------------------------------------- The metabolome content of *Panax ginseng* (A), *Panax notoginseng* (B), *Panax quinquefolium* (C) and *Panax japlcus var* (D) was analyzed by UPLC-Q-TOF MS. Metabolites were extracted with 70% aqueous MeOH, separated on a C~18~ column, and analyzed by MS in the negative mode. For a method validation study, 20 μL samples from each of the four groups were pooled to obtain a quality control (QC) specimen, and the acquisition of the QC specimen was the same as that of the samples. A number of consecutive injections of the QC sample were made to obtain a stable Q-TOF MS system before experimental data acquisition, and the acquisition of data for samples was then started. A QC sample was analyzed every 6 samples throughout the whole analysis procedure. For the QC sample, five characteristic ions (*m/z* 931.5266 with retention time 4.58 min; *m/z* 799.4844 with retention time 6.76 min; *m/z* 1077.5850 with retention time 7.52 min; *m/z* 945.5423 with retention time 8.07 min; *m/z* 793.4374 with retention time 9.52 min) were chosen to examine the shifts in retention time, *m/z* and peak area to assess the stability of the system. The results (shown in Table [S3](#MOESM1){ref-type="media"}) showed that the deviations of *m/z* for each ion were less than 2.63 × 10^−6^, and the relative standard deviations (*RSDs*) of retention time, peak area and peak intensity for each peak were less than 0.13%, 8.54% and 3.45%, respectively. As we know, the excellent stability and repeatability of an analysis system can yield reasonable data, which can be further processed to obtain credible results. The data above demonstrated that the system had excellent stability and repeatability during the analysis procedure. The obtained typical total ion chromatograms (TICs) for the four herbs seemed closely similar (shown in Fig. [1](#Fig1){ref-type="fig"}). Most major peaks found in the TICs appeared in almost all four herbs. The UPLC-Q-TOF MS data for each herb were further processed with Mass Hunter software (version B.06.00, Agilent, America) to recognize the ion peaks and extract the chemical metabolites with the help of the "*find compounds by molecular feature*" function. The extracted metabolites were exported as.cef files, and these files were then imported into Mass Profiler Professional (MPP) software (version B.12.00, Agilent) for further analysis including alignment, normalization, defining the sample sets, filtering by frequency and Venn diagram analysis. As a result, a total of 1634 metabolites were aligned among 42 samples (shown in Fig. [2](#Fig2){ref-type="fig"}). From Fig. [2A](#Fig2){ref-type="fig"}, we found that most of the metabolites presented low frequency, and many of the metabolites presented only once or twice, which was confirmed by the mass-retention curve of metabolites after alignment (shown in Fig. [2B](#Fig2){ref-type="fig"}). The lower frequency metabolites were marked by red color, while the higher frequency metabolites were marked by blue color; the red ones account for most of the metabolites. These lower frequency metabolites will be excluded by setting proper filtering parameters to generate higher quality data, leading to a much more meaningful analysis. In our experiment, the lower frequency metabolites were filtered according to their frequency, and the metabolites that appeared in 100% of samples in at least one group were retained.Figure 1Metabolite profiling of the medicinal herbs in negative-ion mode: *Panax ginseng* (**A**); *Panax notoginseng*; (**B**); *Panax quinquefolium* (**C**); and *Panax japlcus var* (**D**). Figure 2The overall situation of aligned metabolites in 42 samples (**A**) and the mass-retention curve of aligned metabolites (the lower frequency metabolites are marked by red color, while the higher frequency metabolites are marked by blue color). After filtering, there were 98 metabolites in *Panax ginseng* (A), 194 metabolites in *Panax notoginseng* (B), 74 metabolites in *Panax quinquefolium* (C) and 142 metabolites in *Panax japlcus var* (D). To reveal the specific metabolites in *Panax ginseng* (A), pairwise analysis, including A versus B, A versus C, and A versus D, was performed using a Venn diagram (shown in Fig. [3](#Fig3){ref-type="fig"}). The results indicated that 62 specific metabolites were found in A versus B, 58 specific metabolites were found in A versus C, and 66 specific metabolites were found in A versus D. The respectively obtained specific metabolites in *Panax ginseng* were checked manually, and we found that they contained redundant signals caused by different isotopes, in-source fragmentation, and HCOO^−^ adducts. To produce a matrix containing fewer biased and redundant data, the redundant signals were manually removed.Figure 3Venn diagrams of pairwise analyses: **A versus B** (*Panax ginseng* versus *Panax notoginseng*), **A versus C** (*Panax ginseng* versus *Panax quinquefolium*) and **A versus D** (*Panax ginseng* versus *Panax japlcus var*). Finally, the highly reproducible and non-redundant metabolite signals were obtained as follows: 26 specific metabolites were retained in A versus B (shown in Table [S4](#MOESM1){ref-type="media"}), 23 specific metabolites were retained in A versus C (shown in Table [S5](#MOESM1){ref-type="media"}), and 30 specific metabolites were retained in A versus D (shown in Table [S6](#MOESM1){ref-type="media"}). We deemed these retained metabolites the specific and effective metabolites of *Panax ginseng*. The respectively obtained data matrix was then used for further correlational analysis. In addition, due to triterpenoid saponins being the major effective metabolites in *Panax ginseng*, we hoped the final indexes would be triterpenoid saponins. Specific metabolite identification {#Sec4} ---------------------------------- The specific metabolites for A versus B, A versus C and A versus D have been successfully obtained, and their accurate mass-to-charge ratio (*m/z*) values as well as their retention times have been manually recorded. To facilitate their identification, the fragmentation ion for each of the corresponding accurate *m/z* values was obtained by running the analysis under targeted MS/MS mode. Due to triterpenoid saponins being the major metabolites and responsible for the curative effects of the four herbs, the identification of the triterpenoid saponins seemed to be much more important. Actually, the diagnostic ions and fragmentation pathways of the triterpenoid saponins have been previously reported^[@CR19]--[@CR21]^, and we used them to deduce the known and unknown triterpenoid saponin metabolites in our experiment. Metabolite **R23** eluted at 8.09 min gave the precursor ion at *m/z* 793.4388 (shown in Fig. [4A](#Fig4){ref-type="fig"}), indicating that its molecular formula was C~42~H~66~O~14~. The MS/MS spectrum showed that the aglycone ion was at *m/z* 455.3532, suggesting that it was oleanolic acid-type ginsenoside (shown in Fig. [4B](#Fig4){ref-type="fig"}). The fragmentation ions observed at *m/z* 631.3853 and 455.3532 suggested that Glc and Glu A were successively eliminated from the \[M-H\]^−^ ion. Thus, metabolite **R23** was tentatively assigned as chikusetsusaponin IVa (Ch-IVa). Metabolite **X21** eluted at 6.62 min, and the \[M-H\]^−^ ion was observed at *m/z* 799.4850, which indicated that the molecular formula was C~42~H~72~O~14~. The MS/MS spectrum showed that the aglycone ion was at *m/z* 475.3825, suggesting that it was PPT-type ginsenoside. The fragmentation ions at *m/z* 637.4254 and 475.3825 indicate that Glc and Glc were successively eliminated from the \[M-H\]^−^ ion. Thus, metabolite **X21** was deduced as ginsenoside Rf. In the same way, five other triterpenoid saponins including ginsenoside Rc (**Z11**), Ia (**X20**), Re~4~ (**Z1**), malonyl-Rc (Ma-Rc, **R20**/**Z20**) and malonyl-Rb~3~ (Ma-Rb~3~, **R21**/**X15**) were tentatively identified. To determine the structure of the metabolite peak *m/z* 931.5255 (**X1**), an MS/MS experiment was performed, and fragmentation ions were observed at *m/z* 799.4899, 637.4287 and 475.3819, indicating that Xyl, Glc and Glc were successively eliminated from the \[M-H\]^−^ ion. The fragmentation pathway is similar to that of notoginsenoside R~1~ ^[@CR19],\ [@CR20]^; thus, metabolite **X1** was tentatively identified as a notoginsenoside R~1~ isomer (Noto-R~1~-iso). Metabolites **X7**, **X8** and **X9**, having the same precursor ion at *m/z* 841.4961, eluted at 5.20 min, 5.46 min and 6.82 min, respectively. In their MS/MS spectrum, fragmentation ions were observed at *m/z* 799.4901, 637.4284 and 475.3797, indicating that Ac, Glc and Glc were successively eliminated from the \[M-H\]^−^ ion. After losing the Ac group, their fragmentation pathway was the same as that of ginsenoside Rf or Rg~1~. Furthermore, ginsenoside Rg~1~ always eluted prior to ginsenoside Rf^[@CR19]--[@CR21]^; thus, **X7**, **X8** and **X9** were tentatively assigned as Acetyl-Rg~1~, Acetyl-Rg~1~ isomer (Ace-Rg~1~-iso) and Acetyl-Rf, respectively. All of the fragmentation ions of the identified metabolites are shown in Table [S7](#MOESM1){ref-type="media"}.Figure 4MS spectrum of metabolite **R23** (**A**) and MS/MS spectrum of metabolite **R23** (**B**). To confirm the accurateness of the identification, three metabolites including Ch-IVa (**R23**), ginsenoside Rf (**X21**) and Rc (**Z11**) were analyzed using the same profiling procedure as used for the extracts. By comparing the *m/z* values, retention time, and the fragmentation pathway with those of their reference standards, they were confirmed unambiguously. However, those metabolites for which reference standards are commercially unavailable are still tentatively deduced, and their structures could not be unambiguously identified. Correlational analysis of the specific biomarkers {#Sec5} ------------------------------------------------- As is well known, the metabolites in a definite herb present inherent functional relationships or proportional relations, and we can deduce the changes to other relevant metabolites (for which commercial standards are unavailable) according to the changes of the crucial metabolites (for which commercial standards are available), which have the most relevant relationship with others. In our experiment, the crucial metabolites were screened via correlational analysis, and a positive correlation, a relationship between variables in which variables move in tandem and one variable increases as the other variable increases, was determined. The peak areas of the specific metabolites obtained via the integral participated in the positive correlational analysis. Pearson's partial correlational analysis was performed, and the correlation networks were presented in Cytoscape software (shown in Fig. [5](#Fig5){ref-type="fig"}).Figure 5Correlational analysis of the triterpenoid saponins with other specific biomarkers for *Panax ginseng* versus *Panax notoginseng* (**A**), *Panax ginseng* versus *Panax quinquefolium* (**B**) and *Panax ginseng* versus *Panax japlcus var* (**C**). A versus B: As shown in Table [S4](#MOESM1){ref-type="media"}, 26 metabolites were deemed the specific biomarker, and three of the metabolites were ginsenosides, which are regarded as the bioactive metabolites of *Panax ginseng*. The correlation network of the three ginsenosides and the other 23 metabolites is shown in Fig. [5A](#Fig5){ref-type="fig"}. From Fig. [5A](#Fig5){ref-type="fig"}, we found that the peak area of Ch-IVa had a positive correlation with the peak areas of **R5**, **R6**, **R7** and **R12**. However, the peak area of Ma-Rc almost has a positive correlation with the remaining metabolites, including Ma-Rb~3~. These results indicated that as the content of Ma-Rc and Ch-IVa increased, the content of the other metabolites increased. Therefore, Ma-Rc and Ch-IVa were deemed the representative metabolites. However, the acyl bond of malonyl-ginsenosides is extremely unstable, and it is easily hydrolyzed under conditions of acid, alkali, hot water or hot methanol. Moreover, because the relative abundance of Ch-IVa could be above 30%, much higher than that of Ma-Rc and other metabolites (the relative abundance of each metabolite was lower than 10%), the final specific biomarker for A versus B was Ch-IVa. A versus C: As shown in Table [S5](#MOESM1){ref-type="media"}, there were 7 ginsenosides among 23 specific metabolites, and the correlational analysis between the 7 ginsenosides and the other metabolites is shown in Fig. [5B](#Fig5){ref-type="fig"}. From Fig. [5B](#Fig5){ref-type="fig"}, we found that the peak area of ginsenoside Rf had a strong positive correlation with 11 metabolites, including **X1**, **X5**, **X6**, **X8--X12**, **X19**, **X22** and **X23**. The peak area of Ma-Rb~3~ almost has a positive correlation with the remaining metabolites. These results suggested that as the content of ginsenoside Rf and Ma-Rb~3~ increased, the content of the other metabolites increased. Thus, ginsenoside Rf and Ma-Rb~3~ were deemed the representative metabolites. Similarly, because Ma-Rb~3~ is unstable and the relative abundance of ginsenoside Rf could be above 30%, which is much higher than that of Ma-Rb~3~ and other metabolites (the relative abundance of each metabolite was lower than 3%), the final specific biomarker for A versus C was ginsenoside Rf. A versus D: As shown in Table [S6](#MOESM1){ref-type="media"}, there were 3 ginsenosides among 30 specific metabolites, and the correlations between the 3 ginsenosides and the other metabolites were analyzed (shown in Fig. [5C](#Fig5){ref-type="fig"}). From Fig. [5C](#Fig5){ref-type="fig"}, we found that the peak area of ginsenoside Rc had a strong positive correlation with the peak areas of 15 metabolites, including **Z2--Z4**, **Z9**, **Z12--Z19**, **Z21**, **Z23** and Ma-Rc. This result indicated that their content would increase as the content of ginsenoside Rc increases. Although the peak area of ginsenoside Re~4~ had a positive correlation with the other partial metabolites, including **Z5**, **Z7** and **Z29**, the relative abundance of ginsenoside Re~4~ was lower than 10%, which is much lower than that of ginsenoside Rc. Therefore, the final specific biomarker for A versus D was ginsenoside Rc. Verification of the specific biomarkers {#Sec6} --------------------------------------- To verify the specific biomarkers, additional samples (shown in Table [S2](#MOESM1){ref-type="media"}) were collected and analyzed. All samples in Table [S1](#MOESM1){ref-type="media"} and Table [S2](#MOESM1){ref-type="media"} were included in the verification experiment. For A versus B, Ch-IVa was selected as the specific biomarker of *Panax ginseng* according to the above data analysis. The distribution of Ch-IVa in the metabolite profiles of *Panax ginseng* and *Panax notoginseng* was observed (shown in Fig. [S1](#MOESM1){ref-type="media"}). From Fig. [S1](#MOESM1){ref-type="media"}, we found that the peak of Ch-IVa in both samples overlapped with other compounds, and it was difficult to intuitively observe if it was absent or present. Then, we used extracted ion chromatography (EIC) for Ch-IVa from the metabolite profiles of *Panax ginseng* and *Panax notoginseng* and integrated its peak areas. The recorded peak areas of Ch-IVa are shown in Table [S8](#MOESM1){ref-type="media"}. From Table [S8](#MOESM1){ref-type="media"}, we found that the *RSD* of the peak areas of Ch-IVa in *Panax ginseng* was 15.83%, indicating that the content of Ch-IVa in different *Panax ginseng* samples was relatively stable. However, the peak areas of Ch-IVa in *Panax notoginseng* were extremely small, indicating that only a trace amount of Ch-IVa existed in *Panax notoginseng*, which was confirmed by its MS spectrum (shown in Fig. [S2](#MOESM1){ref-type="media"}). From Fig. [S2](#MOESM1){ref-type="media"}, we found that the absolute abundance of the precursor ion of Ch-IVa in *Panax notoginseng* was lower than 5000 counts, and metabolite Ch-IVa was filtered in the process of data analysis. As a matter of course, Ch-IVa was deemed the representative and specific biomarker of *Panax ginseng* for A versus B. For A versus C, ginsenoside Rf was selected as the specific biomarker of *Panax ginseng* according to the above data analysis. The distribution of Rf in the metabolite profiles of *Panax ginseng* and *Panax quinquefolium* was observed (shown in Fig. [S3](#MOESM1){ref-type="media"}). From Fig. [S3](#MOESM1){ref-type="media"}, we found that the peak of Rf was present in *Panax ginseng* and absent from *Panax quinquefolium*. After extracting ion chromatography for Rf from the metabolite profiles of *Panax ginseng* and *Panax quinquefolium* and integrating its peak areas, we found that the *RSD* of the peak areas of Rf in *Panax ginseng* was 14.80% (shown in Table [S9](#MOESM1){ref-type="media"}), indicating that the content of Rf in different *Panax ginseng* samples was relatively stable. Similarly, the extremely small peak areas of Rf in *Panax quinquefolium* suggest only trace amounts of Rf in *Panax quinquefolium*. The absolute abundance of the precursor ion of Rf in *Panax quinquefolium* was lower than 5000 counts (shown in Fig. [S4](#MOESM1){ref-type="media"}), and metabolite Rf was filtered in the process of data analysis. Finally, ginsenoside Rf was deemed the representative and specific biomarker of *Panax ginseng* for A versus C. For A versus D, ginsenoside Rc was selected as the specific biomarker of *Panax ginseng* according to the above data analysis. The distribution of Rc in the metabolite profiles of *Panax ginseng* and *Panax japlcus var* was observed (shown in Fig. [S5](#MOESM1){ref-type="media"}). From Fig. [S5](#MOESM1){ref-type="media"}, we found that the peak of Rc in both samples overlapped with other metabolites. After extracting ion chromatography of Rc from the metabolite profiles of *Panax ginseng* and *Panax japlcus var* and integrating its peak areas, we found that the *RSD* of the peak areas of Rc in *Panax ginseng* was 19.31% (shown in Table [S10](#MOESM1){ref-type="media"}), indicating that the content of Rc in different *Panax ginseng* samples was relatively stable. In the same way, the extremely small peak areas of Rc in *Panax japlcus var* suggest only trace amounts of Rc in *Panax japlcus var*. In addition, the absolute abundance of the precursor ion of Rc in *Panax japlcus var* was lower than 5000 counts (shown in Fig. [S6](#MOESM1){ref-type="media"}), and metabolite Rc was filtered in the process of data analysis. It was feasible to select ginsenoside Rc as the representative and specific biomarker of *Panax ginseng* for A versus D. As a supplement to the verification, we randomly drew 6 samples from each type of medicinal herb in Table [S1](#MOESM1){ref-type="media"} and analyzed the samples using the three selected specific biomarkers through principal component analysis (PCA) as well as clustering analysis. The PCA was carried out, and the results showed that the four groups of samples were clearly separated (shown in Fig. [6A](#Fig6){ref-type="fig"}). Clustering analysis grouped these four groups of samples into four distinct clusters (shown in Fig. [6B](#Fig6){ref-type="fig"}), which was consistent with the result from the PCA analysis.Figure 6Four medicinal herbs were analyzed by principal component analysis ((**A**) samples of *Panax ginseng* are marked in light red, samples of *Panax notoginseng* are marked in blue, samples of *Panax quinquefolium* are marked in dark red, and samples of *Panax japlcus var* are marked in green) and clustering analysis ((**B**) SR1--SR6: *Panax ginseng*; SS1--SS6: *Panax notoginseng*; SX1--SX6: *Panax quinquefolium*; SZ1--SZ6: *Panax japlcus var*). The quality control method and quantitative markers are recorded in the Pharmacopoeia of the People's Republic of China (2010 version), which stipulates that the content of Re + Rg~1~ and Rb~1~ be not less than 0.30% and 0.20%, respectively. In our experiment, we investigated the peak areas of Re, Rg~1~ and Rb~1~ in the four types of samples, and identification by comparison with reference standards was usually required. Taking the peak areas of Re + Rg~1~ and Rb~1~ in the QC specimen as objects of reference, the ratios of the peak areas of Re + Rg~1~ and Rb~1~ in all samples to those in the QC specimen were analyzed (shown in Table [S11](#MOESM1){ref-type="media"}). From Table [S11](#MOESM1){ref-type="media"}, we found that the ratios of Re + Rg~1~ for *Panax ginseng*, *Panax notoginseng*, *Panax quinquefolium* and *Panax japlcus var* were 0.34--1.03, 1.05--1.42, 0.49--0.84, and 0.62--1.01, respectively, while the ratios of Rb~1~ for *Panax ginseng*, *Panax notoginseng*, *Panax quinquefolium* and *Panax japlcus var* were 0.36--1.32, 1.04--1.37, 1.03--1.29, and 0.65--1.17, respectively. The results suggested that the content of Re + Rg~1~ and Rb~1~ in some of the other three herbs was much higher than that in *Panax ginseng* and complied with the quantitative standard for *Panax ginseng*. Therefore, the traditional quantitative markers including Re, Rg~1~ and Rb~1~ cannot assure the quality of *Panax ginseng*, and it was difficult to differentiate *Panax ginseng* from the other three herbs using only the content of Re + Rg~1~ and Rb~1~. The traditional quantitative marker for *Panax ginseng* should be improved, and the results of our experiment remedied it. In fact, ginsenoside Rc and Rf are other major bioactive metabolites in *Panax ginseng* with large peak areas and high peak intensity, and the peak area of Ch-IVa takes up approximately one-sixth to one-fourth that of Rc. They are all easily detected and quantified. Conclusion {#Sec7} ========== In this study, we conducted a metabolite fingerprinting analysis on a set of herbs that belong to the same genus and have extremely similar chemical metabolites to screen specific biomarkers from numerous metabolites in the designated herbs using metabolomics. The specific biomarkers were not easily chosen according to an intuitive comparison of their metabolite profiles but were chosen based on an analysis of the overall metabolites for each herb. The most specific respective biomarkers were obtained via multivariate statistical analysis and correlational analysis. Our results proved that metabolomics is a powerful technology platform for studying the specific biomarkers of medicinal herbs even though they are in the same genus, and our study provided a demonstration of the selection of specific biomarkers for other medicinal herbs. Moreover, this novel strategy can be used not only in the selection of specific biomarkers but also in the quality control of herbs and other compounds. Methods {#Sec8} ======= Medicinal herb materials {#Sec9} ------------------------ The major production areas of the four types of samples were studied, and groups of herbs were collected from different locations (shown in Table [S1](#MOESM1){ref-type="media"} and Table [S2](#MOESM1){ref-type="media"}). Thirty-nine *Panax ginseng* samples (No. 1--6 and No. PG1--PG33) were collected from different production areas such as Jilin province, Heilongjiang province and Geumsan-gun, Korea. Fourteen *Panax notoginseng* samples (No. 7--12 and No. PN1-PN8) were obtained from Yunnan province and Guangxi province. Twenty-five *Panax quinquefolium* samples (No. 13--30 and No. PQ1--PQ7) were collected from Canada, America and China. Twenty-one *Panax japlcus var* samples (No. 31--42 and No. PJ1--PJ9) were collected from Shannxi province, Yunnan province, Sichuan province, Guizhou province, Gansu province and Hubei province. All samples were identified by Prof. Hong-bin Xiao, who is a co-author of this paper, and all voucher specimens were deposited in the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences (Beijing, China). The 42 samples shown in Table [S1](#MOESM1){ref-type="media"} were used to screen and verify the specific biomarkers, while the other samples shown in Table [S2](#MOESM1){ref-type="media"} were used only to verify the specific biomarkers. Chemicals {#Sec10} --------- Ultra-pure water was obtained from Honeywell International Inc. (Burdick & Jackson, Muskegon, MI, USA), and LC/MS-grade acetonitrile was purchased from J. T. Baker (Phillipsburg, NJ, USA). LC/MS-grade formic acid was obtained from Fisher Scientific (Fair Lawn, NJ, USA). The 7 total ginsenosides including chikusetsusaponin IVa (Ch-IVa, **R23**), ginsenoside Rf (**X21**), Rc (**Z11**), Re, Rg~1~ and Rb~1~ were either purchased from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China) or were gifts from the State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University. The purity of all of the reference standards was greater than 98%. Metabolite Extraction {#Sec11} --------------------- Metabolite extractions were performed according to the references^[@CR19]--[@CR21]^. Each of the herbs was pulverized into powder (40 meshes). Each accurately weighed powder sample (1.0 g) was suspended in 20 mL of 70% aqueous MeOH and ultrasonically extracted (40 kHz, 200 W) for 30 min at 30 °C. The extracted solutions were then filtered. This extraction was repeated two additional times. The combined filtrate was evaporated to dryness using a rotary evaporator at 40 °C. The residue was dissolved in 5 mL of 70% aqueous MeOH, and the diluted solutions were filtered through a 0.22-µm nylon filter membrane prior to analysis. UPLC Conditions {#Sec12} --------------- The collected samples were analyzed on an Agilent 1290 UPLC coupled to a 6540 Q-TOF MS system with dual ESI source (Agilent Technologies, USA). All samples were separated on an Agilent ZORBAX RRHD Eclipse Plus C~18~ column (100 × 3 mm, 1.8 µm) connected to a Phenomenex Security Guard^TM^ ULTRA Cartridge using 0.1% formic acid-deionized water (A) and 0.1% formic acid-acetonitrile (B). The optimized gradient elution program was as follows: 0--7 min, 10--40% B; 7--9.5 min, 40--55% B; 9.5--12 min, 55--55% B; 12--15 min, 55--75% B. The temperature was set at 45 °C, and the injection volume was 1 µL. The data rate was set at 10 Hz, and the flow rate was 0.8 mL/min with a split ratio of 1:1. The wavelength was set at 203 nm. ESI Q-TOF MS Analysis {#Sec13} --------------------- It has been proven^[@CR22]^ that triterpenoid saponins are the major metabolites in the medicinal herbs of *Panax* genus, and they have a strong response in negative-ion mode. Therefore, the Agilent Q-TOF 6540 mass spectrometer (Agilent Technologies) was operated in negative-ion mode. The parameters of the ESI source were optimized as follows: gas temperature 300 °C, gas flow 5 L/min, nebulizer pressure 35 psi, sheath gas temperature 400 °C, sheath gas flow 12 L/min, capillary voltage 3500 V, nozzle voltage 1500 V, and fragmentor voltage 280 V. Internal references (Purine and HP-0921) were adopted to modify the measured masses in real time, and the reference masses in negative ion mode were at *m/z* 119.0363 and 1033.9881. The full scan range of the mass spectrometer was *m/z* 100--1700 for MS and MS/MS. Data processing {#Sec14} --------------- When selecting the specific biomarkers, all samples in Table [S1](#MOESM1){ref-type="media"} were analyzed by UPLC-Q-TOF MS to obtain their raw data. Then, the obtained UPLC Q-TOF MS raw data were further processed by Agilent Mass Hunter Qualitative Analysis software (version B.06.00, Agilent, America). The molecular feature extraction (MFE) algorithm was applied to extract metabolites from the total ion chromatograms (TICs) according to their metabolic features, including *m/z*, retention time and ion intensities, and the main parameters of MFE were optimized. The range of *m/z* values was 50 to 1700. Low-abundance ions can be hard to identify if the precursor ion intensity is low, generally below 5000 counts for an Agilent Q-TOF. To produce a matrix containing fewer biased and redundant data, the thresholds of peak filters and metabolite filters were set at 1000 counts and 5000 counts, respectively. All of the extracted metabolites were output to create a.cef file, which can be imported into Mass Profiler Professional (MPP) software (version B.12.00, Agilent) for further data processing. Alignment, normalization, defining the sample sets, filtering by frequency and Venn diagram analysis were applied to process the data. The metabolites with absolute abundance greater than 5000 counts were aligned by retention time and accurate mass; the tolerance windows of retention time and accurate mass were 0.08 min and 15 ppm, respectively. Missing peaks were filtered according to their frequency, and metabolites that appeared in 100% of samples in at least one group were retained. The final metabolites were subjected to Venn diagram analysis to select the specific biomarkers. The correlations between the specific biomarkers were analyzed using partial correlational analysis. Their peak areas were recorded and imported into SPSS for Windows (version 16.0, Chicago, SPSS Inc.). The correlation networks were presented by Cytoscape software (Cytoscape 3.4.0). Electronic supplementary material ================================= {#Sec15} Screening Specific Biomarkers of Herbs Using a Metabolomics Approach: A Case Study of Panax ginseng **Electronic supplementary material** **Supplementary information** accompanies this paper at doi:10.1038/s41598-017-04712-7 **Publisher\'s note:** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This research was supported partly by the grant from National Natural Science Foundation of China (Grant No. 81573839) and the National Science and Technology Major Project of China (Grant No. 2014ZX09201021-009). We thank Professor Xiuwei Yang, the State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, for supplying ginsenoside reference standards. H.P. Wang and H.B. Xiao conceived and designed the experiments. H.P. Wang performed the experiments and analyzed the data. H.P. Wang wrote the manuscript, and H.B. Xiao, C. Chen and Y. Liu revised the manuscript. All authors reviewed the manuscript. Competing Interests {#FPar1} =================== The authors declare that they have no competing interests.
STUDENTS ARE EXPECTED TO HAVE COMPLETED: Linear Algebra, Algorithms and Data Structures - Course Level Recommendations Upper ISA offers course level recommendations in an effort to facilitate the determination of course levels by credential evaluators.We advice each institution to have their own credentials evaluator make the final decision regrading course levels. - ECTS Credits6 - Recommended U.S. Semester Credits3 - Recommended U.S. Quarter Units4 Hours & Credits - Overview Computer Graphics (218 - 15758) Study: Bachelor in Informatics Engineering Semester 2/Spring Semester 3rd Year Course/Upper Division Students are expected to have completed: Linear Algebra, Algorithms and Data Structures Compentences and Skills that will be Acquired and Learning Results: General compentences: - Analysis (PO a) - Abstraction (PO a) - Problem solving (PO c) - Capacity to apply theoretical concepts (PO c) Specific competences - Cognitive 1. To give an overview of the algorithms involved in Computer Graphics (PO a) 2. Studends must know both hardware and software components of computer graphics systems (PO c) - Procedimental/Instrumental 3. Students must know the basics about computer software that supports the development of systems for graphics rendering and modeling (PO j) - Attitudinal 4. Students should be able to use some computer graphic software to solve homework tasks (PO k) 5. Students should work on the homeworks in teams (PO d) 6. Students should generate highly realistic images, using techniques based on physical simulation of light (PO e) Description of Contents: Course Description Introduction, images and displays, 2D & 3D transforms, color models, 3D surface modelling, lighting and surface shading, ray tracing, animation Learning Activities and Methodology: Theoretical lectures: 2 ECTS. To achieve the specific cognitive competences of the course (PO a, c). Practical lectures: 3 ECTS. To develop the specific instrumental competences and most of the general competences, such as analysis, abstraction, problem solving and capacity to apply theoretical concepts. Besides, to develop the specific attitudinal competences. (PO c, d, e, j, k). Guided academic activities (whitout present teacher): 1 ECTS. The student proposes a project according to the teachers guidance to go deeply into some aspect of the course, followed by public presentation (PO e, k). Assessment System: Exercises and examinations are both learning and evaluation activities. The evaluation system includes the assessment of guided academic activities and practical cases, with the following weights: Examination: 40% Exercises: 50% Academic activities without teacher presence: 10% A minimum score of 3,0 is required to pass the exam. Course Disclaimer Courses and course hours of instruction are subject to change. ECTS (European Credit Transfer and Accumulation System) credits are converted to semester credits/quarter units differently among U.S. universities. Students should confirm the conversion scale used at their home university when determining credit transfer.
https://www.studiesabroad.com/destinations/europe/spain/madrid/science-technology-engineering--math-stem-courses-with-locals-in-english/imdy3320/computer-graphics-449506
A study reports that watching TV for four hours a day or more is linked with a 35 percent higher risk of blood clots compared with fewer than 2.5 hours. Scientists suggest taking breaks when binge-watching TV to avoid blood clots, in a research published in the European Journal of Preventive Cardiology. The study examined the association between TV viewing and venous thromboembolism (VTE), a medical condition that occurs when a blood clot forms in a deep vein. The analysis included three studies with a total of 131,421 participants aged 40 years and older without pre-existing VTE. The amount of time spent watching TV was assessed by questionnaire and participants were categorized as prolonged viewers (watching TV at least four hours per day) and never or seldom viewers (watching TV less than 2.5 hours per day). “Our study findings suggested that being physically active does not eliminate the increased risk of blood clots associated with prolonged TV watching. If you are going to binge on TV you need to take breaks. You can stand and stretch every 30 minutes or use a stationary bike. And avoid combining television with unhealthy snacking.” The average duration of follow-up in the three studies ranged from 5.1 to 19.8 years. During this period, 964 participants developed VTE. The researchers analyzed the relative risk of developing VTE in prolonged versus never or seldom TV watchers. They found that prolonged viewers were 1.35 times more likely to develop VTE compared to never or seldom viewers. The association was independent of age, sex, body mass index (BMI) and physical activity. “All three studies adjusted for these factors since they are strongly related to the risk of VTE; for instance, older age, higher BMI and physical inactivity are linked with an increased risk of VTE,” said Dr. Kunutsor.
https://www.gccbusinessnews.com/binge-watching-tv-linked-to-higher-risk-of-blood-clot-study/
In this in-depth interview series, speakers from Enablon’s SPF Americas 2016 offer fresh insights on EHS management, risk and resilience. Pete Bussey, analyst with LNS Research, presented on driving business efficiency through smart EHS management. Here’s the process that Bussey shared for leveraging technology-enabled EHS management to achieve operational excellence. Pete, as a research analyst for LNS, you’re on the leading edge of trends in the EHS industry. What weighs heaviest on the minds of EHS managers right now? As with any part of the organization, EHS managers are focused on adding value to the business. This means aligning with and supporting strategic and operational objectives. We explore this question in our Manufacturing research survey, which shows that the top operational objectives for industrial companies are improving efficiency and ensuring operations are in compliance. So, EHS managers are heading in the right direction by focusing on operational excellence and managing risk, including risks of non-compliance. How exactly do you define ‘business efficiency’? ‘Business efficiency’ is getting the most output with the least amount of inputs. Of course this relates to doing things at the lowest cost possible. Reducing cost is not only about not spending money, but also reducing the impact of other costs, such as those associated with time, quality, reputation, and other potential costs that can affect business results. The bottom line is that when you’re efficient, you’re operating in a more cost-effective way, which involves doing a better job of allocating resources. This applies not just within the four walls of the plant, but also to how an enterprise interacts with suppliers, customers, business partners and others in the extended value chain. At a high level, how does a company go about achieving business efficiency? The pathway to business efficiency is information. Having the right information at the right time for the right people enables better, faster decision-making to help drive efficiency. The key is to use information to increase productivity and reduce risks that can lead to inefficiencies. And what sorts of challenges can EHS managers expect on the road to efficiency? Our research shows that the top barriers to EHS performance improvement are fragmented systems and data, and lack of cross-functional collaboration. Not surprisingly, the basic challenge is the existence of silos, whether they are of systems, people, or communication. I find it interesting that when the same question is asked about manufacturing improvement, the top challenges are exactly the same. So, in a sense, EHS is part of the silo problem, and can also be part of the solution to improve cross-functional operational excellence. So, you’ve explained that improving EHS performance leads to improved overall operational performance. What needs to happen to improve EHS performance? The starting point is to step back and take a big picture approach. This involves aligning with the organization’s strategic objectives and ongoing continuous improvement initiatives, such as Operational Excellence, Lean, or whatever it might be called. Also key is avoiding a “silver-bullet” solution mentality. Improving efficiency and performance will take the right combination of people, process, and technology capabilities. Over time, as I mentioned, EHS has tended to operate in a siloed fashion, with information stuck in organizational and informational silos. Improvement depends on changing that. What role do software and technology play in helping companies improve EHS performance? EHS software systems and technology help on several levels. They can streamline individual tasks and processes such as incident management; automate a whole functional area such as safety and health; and enable an EHS management platform in which most EHS activities are integrated in a single system. Beyond that, the degree to which an EHS platform is integrated with core business systems such as ERP, or even the extended supply chain, can add a lot of value in terms of efficiency and effectiveness. The value EHS contributes depends on the degree of business integration achieved. In our EHS Management survey, we see that well over half of industrial organizations have not implemented dedicated EHS software yet. Of the companies that have implemented EHS systems, most of these are standalone systems. So modern technology is underutilized for EHS. Part of the reason for this relatively low adoption is that the software and technology tools that have been available haven’t been up to the task, perhaps too limited, too difficult and expensive to deploy, or too difficult to maintain or sustain the implementation of the software. Another factor is it takes a while to transition. A lot of companies are getting by on spreadsheets and homegrown software but are recognizing they need to upgrade. The availability of better software solutions and increased pressures on the EHS function have converged such that companies are making the decision to improve and are seeking better solutions. Can you give us an understanding of these solutions? The basic development is the availability of cloud-based EHS management software solutions such as the Enablon platform. Some of the advantages are a broad functional footprint; modularity, which makes deployment easier as opposed to implementing a monolithic technology; more flexible licensing; ease of deploying new functionality; and more powerful analytics. In addition to EHS platforms, other technology innovations are enabling new ways of capturing, organizing and analyzing data. This is based on the Industrial Internet of Things (IIoT), which in turn is enabled by smart devices, Big Data analytics, mobile solutions, and cloud computing. Together, these emerging technologies are providing a lot more information to support decision-making. I recently wrote about this “Digitalization” of EHS management. In a post on the LNS blog, Matthew Littlefield called Enablon a ‘company not scared to openly share its technology and business views with the market and a flair for discussing the success of its customers and own business.’ What would you add for those who are just getting to know Enablon? Well, I’ve seen Enablon steadily evolve and mature as an enterprise software vendor. In fact, watching Enablon reminds me a lot of how things unfolded at SAP. As I explained in the SPF Americas 2016 writeup, Enablon’s maturation as an enterprise software company is demonstrated by its shifting focus to customer value, broader solution footprint, introduction of industry-specific solutions, and incorporation of technology innovations. So going back to business efficiency, how do systems such as Enablon support that goal? Operational excellence is based on a cross-functional platform that aligns people, process and technology capabilities, and mobilizes them toward strategic and operational objectives. This platform is dependent on a number of business functions operating together. We see the key pillars of operational excellence being: 1) operations/manufacturing, 2) asset performance management, 3) quality, 4) energy management, and 5) EHS. If any one of these is not performing well, or collaboration among them is poor, the operational excellence platform becomes unstable and inefficiencies will surface. Quite simply, EHS systems enable operational excellence by integrating EHS into everyday operations. They help overcome the two main barriers to performance improvement: fragmented systems and lack of cross-functional collaboration. But really the game-changer here is the emerging technologies I mentioned before, especially Big Data and advanced analytics. With predictive analytics, companies are better able to move from reactive compliance to proactive risk management. It’s about having new information and insights to anticipate the next thing that’s likely to go wrong, and preventing it: to be predictive and even prescriptive. I’ll sum it up by saying that business efficiency isn’t all about getting rid of people and cutting costs, but rather about continuous improvement based on information. I’ve had the pleasure of interviewing you following two different Sustainable Performance Forums now, and in each I come away knowing more. What are the benefits in your view of the SPF conference series? I see the SPF events as bringing together a community that’s focused on common goals. There’s no substitute for being able to network with your industry peers and learn from each other. And it’s a great forum for Enablon and its customers to learn from each other about what the priorities should be, and the roadmap to get there. Over time, an industry’s ecosystems form around successful enterprise software vendors like Enablon, with partners playing a key role. The SPF conferences are the ideal place for all the players in this ecosystem to gather, learn and improve together. If you liked this post, feel free to explore the LNS EHS Research Library to learn more about approaches to aligning people, processes and technologies to make informed decisions when it comes to improving EHS performance. Download this e-book from LNS Research on driving EHS performance with technology and learn how to monitor and manage EHS performance in relation to Operational Excellence to ensure growth, boost the bottom line, and improve brand image.
https://enablon.com/blog/2017/01/10/bolster-business-efficiency-with-ehs-management-qa-with-pete-bussey-lns-research
This disclosure describes techniques to generate personalized suggestions. The personalized suggestions can be utilized and displayed in different applications. With user permission and consent, past user queries are analyzed to generate personalized suggestions for the user. Failed user queries are analyzed to generate query refinements that would provide a successful response. The personalized suggestions are based on user interests and utilize a prediction of possible future queries from the user. When users activate the feature, the personalized suggestions are suitably presented to the user. Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 License.
https://www.tdcommons.org/dpubs_series/1289/
As noted in the former version of this blog, we will be taking on specific terms in order to label and organize the stories we bring you. The idea is to develop a very specific and fairly rigid system of tagging that allows readers to use the blog as much for actual research as just fun to read. We take the paranormal and related concepts very seriously. Sure, some of it is obvious fakery, others are far more clever and complex hoaxes, but a good portion of what is often termed The Unknown is, in fact, inexplicable. However, UFO reports do not - so far as we know now - have anything to do with accounts of ghosts, for example. Even if we find out later on down the road that the two are somehow related, almost no one experiences them in the same context. While both encounters may cause the viewer fear, he's obviously going to come away from the UFO encounter with a completely different experience than he would a ghostly one and most people who have these encounters experience a lot of the same circumstances and happenings. We'd tag one UFO and the other Supernatural, instead of tagging them both Unknown, for example. Obviously, there is going to be some crossover from time to time. Psychic phenomena best illustrates this: purists make a separation between telekinesis and psychokinesis. The former being the ability to commune with spirits and have them move objects for you; psychokinesis is the ability to move objects through the sheer force of one's will or mental energy. Of course, all of this is theoretical, so we have no real way of knowing how such things are done unless the person doing it informs us ("I talk to a male voice and it moves things for me"), so the system will take shape over the course of time spent here, and all suggestions are welcome. It also has to do with popular usage, known terms, and so on. There is an obscure paranormal phrase I like to use to describe recurring hauntings, veridical imagery or afterimage. I did not create it, but I like the way it sounds, and I think it's power lies in its specificity. Recurring "event" hauntings are well-documented and specialists overwhelmingly tend to agree that they are probably caused by the strength of the emotions that were experienced at the time the event happened - that these emotions somehow "burned" their way into the atmosphere in that area and they surface at a specific time and replay like a recorded image. In general, specialists do not necessarily think that the images involved are actual "spirits" in the way we popularly perceive them - intelligent, animate spirits who can make choices and interact with the living - instead, they are simply recorded images of spirits. That's why I like the phrase; it's specificity communicates this exact concept. But since it is so obscure, I'm not sure if using it would be prudent. The thing about these event hauntings is that Eastern spirituality suggests that those who take their own lives are doomed to repeat the event eternally. Kind of makes you wonder if those spirits are just hollow, imagistic impressions in the atmosphere, or The Damned, themselves... At any event, we'll discuss more about tags and how to use them, as well as which tags we're employing and how, as we go along.
https://oddblog.theweirding.net/2007/03/terms.html