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This case should alert clinical oncologists to pay attention to mental symptoms after prescribing a corticosteroid.
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We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).
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RESULTS: Careful blood cell monitoring showed a pronounced diurnal variation of WBC (2.9-4.2x10(9)/l in the morning and 3.6-7.1x10(9)/l in the afternoon) and granulocytes (0.8-1.4x10(9)/l and 2.9-5.5x10(9)/l, respectively).
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Treatment with diazepam led to resolution of symptoms within 6 hours, and there was no recurrence at 6 weeks' follow-up.
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PSL was commonly effective in inducing remission in very elderly patients (7 of 9 patients; 78%).
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RESULTS:Haze, uncorrected visual acuity (UCVA), and BCVA improved in all patients.
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CONCLUSIONS: Interventions aimed at reducing pain associated with CIPS may include the initiation of calcium-channel blocker therapy and conversion to an alternative calcineurin inhibitor.
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Adalimumab, a fully human, immunoglobulin G1 monoclonal antibody that binds to tumor necrosis factor, has been approved for the treatment of moderate-to-severe psoriasis, in the U.S., Europe and elsewhere.
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We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.
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Bilateral percutaneous nephrostomy catheters were placed in the renal pelvises, and local irrigation with amphotericin B was performed for 3 weeks.
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This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.
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As an apparent result of their immune modulating activity, there has been an observed association between the use of these agents and the development of a wide range of infections, most notably Mycobacterium tuberculosis.
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Extended-release tolterodine 4 mg/day was then prescribed to manage overactive bladder.
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Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.
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METHOD: Case report.
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CT-scan disclosed right ethmoid sinusitis that spread to the orbit after surgery.
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Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.
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Following this occurrence of respiratory depression nebulised morphine was discontinued and no further events occurred.
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Therefore long-term suppressive antibiotic treatment was not indicated.
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Previous successful treatment with one ACE inhibitor does not rule out the vasculitis caused by the drug from the same group.
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OBJECTIVE: We sought to describe the clinical course after copperhead bites.
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The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.
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One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.
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As a result of the advances in acute rheumatology and improved emergency services, an increasing number of patients survive episodes of severe disease and complications of immunosuppressive therapy.
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We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.
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To avoid menstruation by the female patient just in the critical stage, we modified her menstruation cycle by testosterone.
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He is being followed with repeated imaging studies for a small abdominal aneurysm.
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Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.
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The safety profile of this treatment in critically ill patients has not been fully evaluated.
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We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.
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We suggest that in patients treated with olanzapine, CK concentrations should be checked on initiation of therapy, within the first 48 hours, and weekly thereafter for at least one month.
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OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.
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Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.
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A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.
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Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.
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Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms.
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Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.
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RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.
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Perforation of the bladder seems to be iatrogenic (primary) or drug-induced (secondary).
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A patient with a primary malignant brain tumor on chronic corticosteroids presented with a clinical picture of cord compression and was diagnosed with SEDL.
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A severe lidocaine intoxication by cutaneous absorption is described.
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We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).
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This was characterized by inflammatory arthritis and an urticarial and papulosquamous rash and was accompanied by high titers of antinuclear, double-stranded DNA, glomerular-binding, and histone antibodies and by reduced levels of the C4 component of complement.
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A 55-year-old Caucasian man was admitted to hospital with triple vessel disease.
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A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.
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In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.
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Physicians and patients must use more caution with teratogenic prescription drugs.
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The interaction between phenytoin, thyroid function, and thyroid replacement therapy is discussed.
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Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.
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Salmon calcitonin in the treatment of post herpetic neuralgia.
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Mental status, vital signs, and all laboratory parameters including thyroid function tests, normalized.
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Rarely, pleural effusion and/or pulmonary hemorrhage may occur.
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Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.
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Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.
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She was suffering from an unspecified interstitial lung disease, papillary thyroid carcinoma which had been treated, hypoparathyroidism after thyroidectomy for which she was receiving dihydrotachysterol and calcium, and atrial fibrillation and congestive heart failure as a result of mitral stenosis.
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Ten of them were given the agent while the femoral arteries were compressed, to prevent loss of the agent into the external iliac arteries.
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METHODS: Ten consecutive patients with culture proven MDR-TB were treated with the novel antibiotic drug linezolid in combination regimens for 6-40 (median 17) weeks and followed up 11-50 (median 24) months after end of treatment.
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Two other patients were treated with clotrimazole as well as propamidine isethionate and neomycin sulfate-polymyxin B sulfate-gramicidin from the outset, and had an excellent response to medical therapy.
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The three index patients underwent: (1) left stellate ganglion block; (2) beta-blocker challenge; and (3) electrocardiographic stress testing.
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In one case the recognition of anterior vitreous face contact to the cornea was delayed by the severity of the corneal edema.
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We report four cases of severe corneal ulceration in methamphetamine abusers.
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The patient's beta-blocker therapy may have masked additional signs of NMS.
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OBJECTIVES: This article focuses on those patients where particular agents should not be used: i.e. 'when not to use what'.
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Amphotericin B overdose in pediatric patients with associated cardiac arrest.
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Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.
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Antibiotic-associated neutropenia.
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The most common complications of the use of central venous catheters include infection and venous thrombosis whereas pulmonary septic emboli are rare.
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CONCLUSION: Pancreatic enzyme intolerance, although rare, would be a major problem in the management of patients with CF.
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Successful rescue of severe recurrent hepatitis C with interferon and ribavirin in a liver transplant patient.
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Her clinical symptoms improved with discontinuation of pranlukast and administration of systemic corticosteroid.
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A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.
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Skin rash and splinter hemorrhages from ganciclovir.
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Oligohydramnios and pulmonary hypoplasia: a case in which involvement of an angiotensin II receptor antagonist was suspected.
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The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.
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Prompt diagnosis of WE is important because it is potentially fatal and readily treatable with thiamine supplementation.
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Despite normal coagulation parameters, the cerebral hematoma enlarged over 36 hours, as documented by sequential computed tomographic scans, to produce significant mass effect, which prompted surgical evacuation.
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An 8-year-old girl with pauciarticular disease, antinuclear antibody, and uncontrollable iridocyclitis underwent 16 plasma exchanges with 5% albumin solution as replacement; despite removal of antinuclear antibody, her eye disease and arthritis were not helped.
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It has a significant adverse effect profile, with 30-45% of patients reporting cardiac adverse effects and 15-20% experiencing noncardiac events.
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We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis.
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We present an exceptional case in which full-thickness eyelid necrosis ensued following intralesional injection of corticosteroids in a capillary hemangioma.
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We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.
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Muscle involvement is also common, although it usually remains asymptomatic.
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CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.
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Seventeen months after recovery, the patient was rechallenged with ART without recurrence of lactic acidosis.
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Antibodies to native or ultraviolet-irradiated DNA were not demonstrated.
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Laboratory investigations for uveitis were negative and the patient required systemic and intensive topical steroids with cycloplegics to control the inflammation.
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Mycophenolate mofetil-induced neutropenia in liver transplantation.
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Perilymphatic atrophy can be a complication of intralesional corticosteroid injections given for the treatment of conditions such as psoriasis, alopecia areata, and keloids, and intraarticular corticosteroid injections given in diseases such as rheumatoid arthritis.
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This is believed to be the third case of bacteraemia outside of Asia due to C. indologenes and the first in a diabetic child not otherwise immunocompromised.
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IL-2 was part of the regimen.
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Thus, our report suggests that SKT could be a first-line agent for the conservative treatment of TOS.
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He subsequently had a resolution of all signs and symptoms, suggesting that these alarming events were a toxic but reversible side effect of the chemotherapy.
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A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.
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OBJECTIVE: To present a previously unreported cause of neurologic compromise after cervical spine surgery.
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A clinical study was initiated to determine if this mode of treatment would be effective against certain primary and metastatic cutaneous malignancies.
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School-based methylphenidate placebo protocols: methodological and practical issues.
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This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.
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6-Thioguanine (6-TG) is a thiopurine analogue that is closely related to 6-mercaptopurine (6-MP) and azathioprine (AZA).
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CONCLUSIONS: The normal host response to a cosmetic filler is a weak granulomatous reaction.
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Two patients with severe dialysis osteomalacia, whose fractures and deformities had become progressively worse over 3 years, were treated with desferrioxamine (DFO).
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