Datasets:

Stardrums

/

pico-breast-cancer

like 2

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[ "Clinical", "outcomes", "of", "ethnic", "minority", "women", "in", "MA", ".", "17", ":", "a", "trial", "of", "letrozole", "after", "5", "years", "of", "tamoxifen", "in", "postmenopausal", "women", "with", "early", "stage", "breast", "cancer", ".", "Aromatase", "inhibitors", "are", "widely", "employed", "in", "the", "adjuvant", "treatment", "of", "early", "stage", "breast", "cancer", ".", "The", "impact", "of", "aromatase", "inhibitors", "has", "not", "been", "established", "in", "ethnic", "minority", "women", ".", "The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "impact", "of", "letrozole", "on", "minority", "women", "in", "MA", ".", "17", ",", "a", "placebo", "-", "controlled", "trial", "of", "letrozole", "following", "5", "years", "of", "tamoxifen", "in", "postmenopausal", "women", "with", "early", "stage", "breast", "cancer", ".", "Retrospective", "comparison", "of", "disease", "-", "free", "survival", "(", "DFS", ")", ",", "side", "effects", ",", "and", "mean", "changes", "in", "quality", "of", "life", "(", "QOL", ")", "scores", "from", "baseline", "between", "Caucasian", "and", "minority", "women", "was", "performed", ".", "Minority", "(", "n", "=", "352", ")", "and", "Caucasian", "(", "n", "=", "4708", ")", "women", "were", "analyzed", ".", "There", "was", "no", "difference", "between", "these", "groups", "in", "DFS", "(", "91.6", "%", "versus", "92.4", "%", "respectively", "for", "4", "year", "DFS", ")", ".", "Letrozole", ",", "compared", "with", "placebo", ",", "significantly", "improved", "DFS", "for", "Caucasians", "(", "HR", "=", "0.55", ";", "P", "<", "0.0001", ")", "but", "not", "for", "minorities", "(", "HR", "=", "1.39", ";", "P", "=", "0.53", ")", ".", "Among", "women", "who", "received", "letrozole", ",", "minorities", "had", "a", "significantly", "lower", "incidence", "of", "hot", "flashes", "(", "49", "%", "versus", "58", "%", ";", "P", "=", "0.02", ")", ",", "fatigue", "(", "29", "%", "versus", "39", "%", ";", "P", "=", "0.005", ")", ",", "and", "arthritis", "(", "2", "%", "versus", "7", "%", ";", "P", "=", "0.006", ")", "compared", "with", "Caucasians", ".", "Mean", "change", "in", "QOL", "scores", "for", "minority", "women", "who", "received", "letrozole", "demonstrated", "improved", "mental", "health", "at", "the", "6", "-month", "assessment", "(", "P", "=", "0.02", ")", "and", "less", "bodily", "pain", "at", "the", "12", "-month", "assessment", "(", "P", "=", "0.046", ")", ".", "Letrozole", "improved", "DFS", "in", "Caucasians", "but", "a", "definite", "benefit", "in", "minority", "women", "has", "not", "yet", "been", "demonstrated", ".", "Minority", "women", "tolerated", "letrozole", "better", "than", "Caucasians", "in", "terms", "of", "toxicity", ".", "These", "results", "need", "confirmation", "in", "other", "trials", "of", "aromatase", "inhibitors", "." ]

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