ids
stringlengths 6
10
| seqs
stringlengths 11
1.02k
| texts
stringlengths 108
11.1k
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Q9K1R6 | MTVKTRFAPSPTGYLHIGGVRTALFSWAFARHHKGEFLLRIEDTDLARSTAESVNIILDGMKWVGLNYDNADNVVYQTRRFDRYKEVIAELLEKGHAYYCYCSKEELEAMREKAEKEGSATYDRRWRPEVGKTLPEIPSDVQPVVRFKTPLDGVTKWTDLVKGEISIPNEALDDLIIARADGTPTYNFCVVVDDYDMGVTHVIRGDDHVNNTPKQINILKAIDANLPEYGHLPMILNEQGKKISKRSGDTVAITDFGAMGILPEAMLNYLARLGWAHGDDEFFTMEQFIEWFDLKDVSPSPSRMDLKKLYWINGEHIKITPNGKLAELVKPRLALRDIHETEKPALEDVLELVKDRPQDLNTLADECFYFYVKQTPAEADVQKHWDDEAAARMLRFAERLEGLEDWNAEAIHDLFKPFCDEEGIKMGKLGMPLRLAVCGTAKTPSVDAVLALIGKEEVLKRIRA | Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic Activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
Sequence Mass (Da): 52717
Sequence Length: 464
Subcellular Location: Cytoplasm
EC: 6.1.1.17
|
A9A423 | MDEEIKHEIRKMALQNAFEHGGQTQDKIILGKILGTKPEFRTKVKEISGEISEIVASVNQLSPEEQQKEMEEKFPEALAPKEKIEEREGLPELKDAIQGKVVTRFPPEPNGYPHIGHAKAAIINSEYAKMYGGKFILRMDDTNPEAERMEYHAAIKVGLEWLGIEFDQVKSTSDDMEVFYEKGIELINSGKAYVCTCKREDISQNRRERKACKCSMEDVGKNNKNWEKMQNKFKPGEAIVRFRGDMKADNAVMRDPVLLRIIDEKHYTVGDKYRIWPSYDFAVAIEDSIDGVTHAFRSKEFELRKELIDAILDALGMRKPQQGFFSRLEFKGMPISKRIIKPLIEEGKVSWYDDPRLPTLEALRRRGIKPEAIRKFIMSLGLTKANTLAPFDALEAFNRKFVDADSMRLFMVKNAKKLKIKNLQSTIVEVPNHPINDLGKRKIEITEDFYISGDDSEAIKEQSTIRLLGLGNVKITKIGNELEGEFERDGDSSNILKIQWVPQKTAHEIKMIIPKILFNDEEFNEDSLEELDVYTEPQYLQLKEGEEIQFVRFGYCRKDSQNQAIFTHK | Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic Activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
Sequence Mass (Da): 65521
Sequence Length: 569
Subcellular Location: Cytoplasm
EC: 6.1.1.17
|
Q2Y8L6 | MIRTRFAPSPTGYLHIGGARTALFSWAYARKHGGKFVLRIEDTDLERSTAQSTQAILDGMAWLGLDYDEGPFYQMQRLARYHEVAEQLLRRGQAYYCYCSREELDAMREQQRAAGLKPRYDGRWRDSREEPPAGVKPVVRLKNPLDGEVTFKDLIKGEITVANSELDDLVLLRGDGVPTYNFGVVIDDLDMNITHVIRGDDHVNNTPRQINILKALGAPLPQYAHVPMILGADGERLSKRHGAVSVMQYREDGYLPEALVNYLARLGWSHGDEEIFSREQLVEWFDLSNINRSPAKFNPEKLQWLNQQYLKTADNERLAELVKPFLAADGCDVTGGGTPDLRKVMNLLKERVNTIAELADAAVYFFRPLEPAEELRAQYFSAEAKGPILDLRTKLATLEWEGHAINDAIKASATAHGVKMPKVAMPLRVMVTGEAQTPAINAVLELLGREETLRRMDRQLEYFLS | Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic Activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
Sequence Mass (Da): 52513
Sequence Length: 465
Subcellular Location: Cytoplasm
EC: 6.1.1.17
|
B2IYI1 | MTVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGKFILRIEDTDLERSRPEYTDNILEGLRWLGLNWDEGPFFQSQRLDLYKEAVQKLLDQGLAYRCYTTSEELEALREAQKARGEAPRYDNRHRNLTPEQRAAYEAEGRSYVIRFKIEDGREIVWNDLVRGKMSWRGSDLGGDMVIARASEEGSGQPLYNFVVVVDDIDMQITHVIRGEDHIANTAKQILLYEAMGAKIPEFSHTPLILNMEGRKLSKRDGVTSISEFQKMGFTAEGLVNYMTLLGWSPPDSTQEIFTLETAAKEFGFERVNKAGAKFDWDKLDWLNSQYIHNTPVDKLTDLLIPFWEAAGYKFDGGRDRAWLEQLVTLISQSLTRLVDAVPQSQLFFSDTVEFSEEGSTQLKQEGSTAVLEAIVTALENQPQLSEAAAQDIIKQVVKEQKVKKGLVMRSLRAALTGDVHGPDLIQSWLLLNQIGLDKSRLSRAITEAN | Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic Activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
Sequence Mass (Da): 54437
Sequence Length: 481
Subcellular Location: Cytoplasm
EC: 6.1.1.17
|
B1VZ06 | MANAPFPKLSASLDQGRPHRVRFCPSPTGNPHVGLVRTALFNWAFARHHQGTLVFRIEDTDAARDSEESYQQLLDSMRWLGLDWDEGPEIGGPHAPYRQSQRMDLYKDVAEKLLAAGYAYPCYCTTEELDTRRDAARAAGKPSGYDGHCRDLTAEQKAAYEAEGRTSIVRFRMPDEAITFTDLVRGEITVQPENVPDYGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLLSSTPRQIALYRALIELGIAKDTPAFGHLPYVMGEGNKKLSKRDPQASLNLYRERGFLPEGLLNYLSLLGWSIAEDRDIFSMDELVAAFDIKDVNANPARFDLKKCEHINAEHIRMLDVKTFTEACGPWLKAPFAPWAPEAFDAEKWTRIAPYAQTRVTVLSDITDNVDFLFLDEPVEDEASWTKAMKGDPVALLTTARANLEAADWSDPESLKNAVLTAGEAHGLKLGKAQAPVRVAVTGRTVGLPLFESLEILGRDRSLARVDAALAKLTA | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Catalytic Activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
Sequence Mass (Da): 55894
Sequence Length: 504
Subcellular Location: Cytoplasm
EC: 6.1.1.17
|
B7J7S6 | MSFQSMASIAEAAREVAAASDLNTLEQIRLRWLGRKGVLTEAMQQLGQLSPETRREAGQLLNERKSEIQSLLQERKAELEAAAIHARLQQERLDVTLPGRREACGSAHPIRQTLEWIEHYFFGLGFETSDGPEIEDDYHNFAALNIPEDHPARAMHDTFYLDATRLLRTQTSTVQIRFLESHQPPLRMIATGRVYRRDSDITHTPMFHQVEGLLLDERASFADLRGLLSDFLHGFFAKPDLPVRFRPSYFPFTEPSAEIDIGCVICGGSGCRVCKQTGWLEVLGCGMVHPAVLAGAGVDGERFSGFAFGMGVERLTMLRYGVNDLRLFFENDLRFLKQFS | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38363
Sequence Length: 340
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q728R9 | MDLLKELESLVPELERGLGQASSLQELEEQRIAFLGRKGRLAQVMAHLPELAPAERPRVGQAANTVKQALTELFEQRKVVLEQAKEAAALSRFDPSLPGRMPWRGSLHPVTLVMEEICSVFGALGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLYITESILMRTHTSPLQVRTMKSLRPPVAAIAPGKVYRRDSDITHTPMFHQIEGFMVDHNVSMAELRGTLTSFLRTVFGGDTRVRFRPSFFPFTEPSAEVDISCCICGGKGHVGNEPCRVCKTTGWVEILGCGMIDPEVFKSVGYDPEVYTGFAFGLGVERVAMLKYGIGDLRMFFENDVRFLSQFA | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38526
Sequence Length: 345
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q54KS8 | MNKEIFNSKLFEKLDKDNLIENSREWSNEIDSTWNYNDVVGILKSWESLNTISLEYIDSIVNCLTETGKDILINGSPEAKLYNILTEQGMSPADANKQFGATAFGSAKNKGWIEVKAGKIFKKVESINDIVKSDLSIPDLSKLDSKTLEQYKKSRFIEEKKLSYYRVTKGEQYNKRSKELSDLTIEMLKDDSWEKESFKVNINAMGVVPEQGYRHPLNKVKNEFKQIFLDMGFEEMPTFNFVENGFWNFDALFQPQQHPARELQDTFFIKDPKTSHDFSDEYCERVKQVHSVGGYGSLGWIYDWKLEEAEKNILRTHTTAVSARMLYKLAQNGFKPKKYFSIDRVFRNETLDATHLAEFHQVEGVIADVDISLGHLIGVISEFFKRLGIDNVRFKPAFNPYTEPSMEIFGYHPILKRWVELGNSGIFRPELLLPMGIPENVRVAAWGLSLERPTMIKYGLDNIRAIFGNSINVNFIKNNPICMFESK | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 56174
Sequence Length: 487
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q9W3J5 | MHPDLTERILQHLETTDKADTLDLAALFAEDHQKIVGSLKSIQAHGELVTAETVTHKSLGLTDEGRAVVENGSHEALVYDLVPPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTPPLVRRKVDTITDVVRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTVEMLANGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNFDALYQPQQHPARDAHDTFFVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHTTAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGDLIGTLYEFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPENVNVIAWGLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLDHA | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 55684
Sequence Length: 498
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
A6L2I3 | MLAKIEQLLQEIEGLQAANAEELEALRIKYLSKKGAINELMADFRNVPAEQKKEVGMKLNELKNKAQERIASLKEAFETQDNSAAEMDLTRTAYPIELGTRHPLSIVKNEIIDIFHRLGFSIADGPEIEDDLHVFTAMNFAEDHPARDMQDTFFIEANQEDVKKNIVLRTHTSSVQARAMEHSQPPIRIICPGRVYRNEAISYRAHAFFHQVEALYIDKNVSFTDLKQVLLLFAKEMFGEDTQIRLRPSYFPFTEPSAEMDISCNICGGKGCPFCKGTGWVEILGCGMVDPNVLEANGIDSKVYSGYALGMGIERITNLKYRVNDLRLFSENDTRFLKEFEAAN | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38979
Sequence Length: 344
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
B1VA93 | MHNKINLLKEKFEHDLAKNKNSLENLIYLEQKFLGKKSFLQELNQTLKNIPSEKKPAIGKLINEFKKTIILSLQKEKQYLKTQKMNLELMQESVDVNLPGFNFSTGSIHPLYQIIEQLEDLFLSLGYEIKDGNEIESDFYNFEMLNIGKNHPARAMQDSFYINPQKLLRTHTSNIQVKEMLANEGKPLKIISSGKVFRKDNDDATHSHQFMQLEGLVIDQKINFLNLKETILTIIKELFGDSQEINIRPSYFPFTEPSIEVDLVIRKKDNSKEYLEILGAGLVHPQVLLNANYNPEKYQGFAFGIGIERIAMIKYQIENIRHFYQNDIRFLKQFSKKVKHENS | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 39999
Sequence Length: 343
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
A5K9S0 | MQAKAQEEQKGEELSQFLQALEEEFALCQEGGGDKREADGPSLENAEAEELANRRAYYLQLKEERNVLVEESKHVTSLHMSSKHNIEHAKVLGMAKKLETLYYVVNHVRSFNTYQLTEEGKEYLRDGSPEHVTLRYVMEQEGCTLEDLKKLFGKKGEIGLNINLKKKKIELRKSDKRLFPHVEGSAHSLVDETRCYLQKVEAHGNDEGALVSHLKGILPPEKGEKKEEDEANNLIKELKKRKLIEAKKISYIYIIRTNLFTKEIKKQITDLTYLLIKNEEYKKYQVKKYNFFSSGKKMNKGNIHLLIRQMRTFKDVFVSLGFEEMNTHNYVESSFWCFDALYIPQQHPSRDLQDTFFIKVPEMCQEEFTDQSYIENVKRVHSVGDYGSFGWNYQWELKSTKKNVLRTHTTANSCRALFQLAKEYQKTGSIIPKKFFSIDRVFRNENLDSTHLAEFHQVEGLIIDRNLGLSHLIGTLSAFYKYIGISKLRFKPTFNPYTEPSMEVYGYHEENKKWLEVGNSGIFRPEMLRAMGFPPEVSVIAWGLSLERPTMIKYSIRNIRDLFGYRSVI | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 66323
Sequence Length: 569
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q5RFA2 | MADGPVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKRWELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVILKTYWVSKGSAFSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQEAA | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 57564
Sequence Length: 508
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
B2RLI5 | MKERINQLLQEIGQCVAATVEEAEALRIKYLSKKGEIARLFDDFRLVPSEEKKQIGQMLNELKNKAQEHINSLRERAQAGSAQASAETDLTRTSYPTRLGTRHPISLVKQEICEIFARLGFSIADGPEIEDDWHVFSSMNFAEDHPARDMQDTFFIEHRPDVILRTHTSSVQSRVMEKTQPPIRVICPGRTYRNEAISYRAHCFFHQVEALYVDKDVSFADLRQVLLYFAQEMFGAETKIRLRPSYFPFTEPSAEMDISCNICGGKGCNFCKHTGWVEILGCGMVDPNVLDNCGIDSKKYSGYALGMGIERITNLKYRVKDLRFFSENDLNFLEQFKSVH | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38940
Sequence Length: 340
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q7TV42 | MSATISLQQLTDQLDALEAEAVSAIAAAADADALEQLRVSLLGKKGRLSGVLGAMGKLPSEERPLVGQRANVLKTQVQNLLGERLQVVKAAALADRLLQETIDVTAPASGIPVGHRHPLITTTEQIVDLFSGLGYRVAEGPEVETDHYNFSALNIPEDHPARDMQDTFYLGGNLLLRTHTSPVQIRYLEENPPPVRIVAPGRVYRRDAVDATHSPVFHQVEVLAIDEGLDFSHLRGTVMAFLKAFFGDMPVRFRASYFPFTEPSAEVDVQWRGRWLEVMGCGMVDPAVLEGLGLDPERWSGFAAGLGVERFCMVRHGIDDIRRLYTSDLRFLEQF | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 36955
Sequence Length: 335
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q9I0A3 | MENLDALVSQALEAVRHTEDVNALEQIRVHYLGKKGELTQVMKTLGDLPAEERPKVGALINVAKEKVQDVLNARKTELEGAALAARLAAERIDVTLPGRGQLSGGLHPVTRTLERIEQCFSRIGYEVAEGPEVEDDYHNFEALNIPGHHPARAMHDTFYFNANMLLRTHTSPVQVRTMESQQPPIRIVCPGRVYRCDSDLTHSPMFHQVEGLLVDEGVSFADLKGTIEEFLRAFFEKQLEVRFRPSFFPFTEPSAEVDIQCVICSGNGCRVCKQTGWLEVMGCGMVHPNVLRMSNIDPEKFQGFAFGMGAERLAMLRYGVNDLRLFFDNDLRFLGQFR | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38064
Sequence Length: 338
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q5SGX2 | MLEEALAAIQNARDLEELKALKARYLGKKGLLTQEMKGLSALPLEERRKRGQELNAIKAALEAALEAREKALEEAALKEALERERVDVSLPGASLFSGGLHPITLMERELVEIFRALGYQAVEGPEVESEFFNFDALNIPEHHPARDMWDTFWLTGEGFRLEGPLGEEVEGRLLLRTHTSPMQVRYMVAHTPPFRIVVPGRVFRFEQTDATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGPDSKVRFQPVYFPFVEPGAQFAVWWPEGGKWLELGGAGMVHPKVFQAVDAYRERLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIRYFFGGRLKFLEQFKGVL | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 39259
Sequence Length: 350
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q8DL09 | MTSPILDRDRLSQQLQDLQAKALQAIATASTLDALEQLRVAYLGKKGELSQILALMGKLPAGDRPTIGTLANTLKEKLLQELEARRATLQAEKIAAQLAAESLDVTMPGVYRPQGHIHPLHSTIDRILDIFVGLGYTVANGPEMETEYYNFEALNTPADHPARDMQDTFYLPDGNLLRTHTSSVQIRYMELYEPPIRIVAPGRCYRRDTEDATHAAVFHQIEILAVDEGLTFTDLKGTVTTFLAELFGDVPIRFRASYFPFTEPSAEVDVQWQGRWLEVMGCGMVDPAVLKNVGYDPEVYTGFAAGFGVERFAMVLHQIDDIRRFYTSDLRFLRQF | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 37729
Sequence Length: 336
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q979U4 | MSEISKNEALILKYLASKNQEIEESNIEIKGLSRQDIASATSWLQVKGLIDVKTREEVAYVLTDEGKRYAENGLPELRAYSILKRKGKLSLRDLQEAMPDEYKIVLAQLAKFGITPKNGVLEYSDGHIEAEISRRQRFLSDLNTDDQEMIEHFKRRKNVIEEKKRSVRIVSINSKGLEQLNNFDQFEAIGEIDSGIITSQAWKTAPFRKYDLDAPVSPTKSYAKHPLVYFINEIRRIFLDMGFTEMSGHYIESALWDMDALFIPQDHPARDMQDTFYVKDSNFTIEHPEIEKRIKRIHERGFDGYSGWGYRWSSDDGKKLILRTHTTVTTARYLYEHNTYPQAIFSVEKVFRHESVDWKHLAEFYQIEGAVYDKNVSVATLKWILRTFYGKLGFEKIRLVPSYYPYTEPSLDVVVEVDGKEMELGGSGIFRPEVGKILGLKAPVMAWGMGLERLAMLYYGLTDVRDLYNTDFSFLEGYKIKY | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 55848
Sequence Length: 482
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q83GS9 | MDEIQDIEGLTRRALQAISRIDTLRDLTKLKNDNLGSTSWLAKYSASIKILSQEKKPIIGKAVSEARRKILEACQDRDLALRLNAQNEQFTRETLDITALPTRIFPGARHPIHVLQDKILDFFLMRGWSVVEGPELESEWLNFDALNIGPFHPAREESDTIFAEPRSASMLLRTHTSPVQLRALVSNPLPLYCVSSGKVFRSDPLDATHTPVFHQLEGLVCDRNITLGHLKGTVEDLAGYLFGAEVNLRMRCNYFPFTEPSAEFDISRDGIDWTEWGGCGLVNSKVLSMAGIDTVHYTGFAFGFGLERTLQFIHSLSDMRDIVEGDIRFSQQFGLK | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 37840
Sequence Length: 336
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
A1WMG9 | MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAINLAKQAIEAALNARRQALADAQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLFGSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYVEGGTAGAPNLLRTHTSPMQIRHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKDLKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGMGLDRLTMLRYGVSDLRLFFDGDIRFLSQFR | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 38808
Sequence Length: 350
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q6F166 | MIITRKWLEKYLDLSNITNEQISVCLNSLGFEVEQEIDYSKLNTKLVIGHIEESDPIEGTKLKKTKTRIGENKYATILSTSRNIEEDKFAIVALPGAKLANGLELENREILGILSEGMFCGFNEIGLPNSVLTEDEQQDVYYIDSIYKNMDEMVGREISEVLNFDDYTFEVDLTLNRSDALAAKQLVKEIANYFDLKINNNEHKVKFEKPTESITIDLNKKVEDEVNTVSHTFIGLKNTNTPFDSSHDVWLKHSNVKSAQNKFENIANMATLISGQPFILIDADKVNGELTLTKQTIDEKELIVLKSGNSIVNILGLKTEDKFKVTEETVTMLVVMLNLDQISMRKQQRNLNVSTVDTQRYAKPLNPNLYDQGIDELVSILDEYKMLEDVQKVVTTVQKQNYDNVYSITLEKVQDILGIEITVEEIISLFRTLDIEISVKKSELTFTVDKNRTDLYGKNDLCEEIARLYGYDNIIEQPLEYVSFKKTKNLDKKLKDKLSDYLVGAGFNNIKTYSLTDIESNKTWNLFKVKDPVVLMSPLSIQRETFRNNLSKSMIDTIIFNANNGNKSVKFFEMADIFALNGFRQSNLCFGVSGEAITDSLSQVHIKSNYAYISSILMSVLDLYKVDVTNVTFEVNDKAIDEIHPYINATVKYKNKKIGFIYKLNPAFEQANKIYPTFICEVNLNLLLEIADKVHVTSEISKFQKSTRDISFELSNDVNFDTIVKAMLKDLNYLTNYKVIDKYSDEQMDKENISSLTVKLSFNSLDHQLTEKEINDDFEKILNNLKELKVKVR | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 90755
Sequence Length: 793
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q601U6 | MLFSLRRLKKLANLEAFSDQKVIDSLINLGFEVDQITKLNEISGIKFGQILEIRKNPEADNLWICKVQFADKIREIQTAAKNVIENKQVLAFIPGSKSGNTTFLAKKLRGHISEGMLISAVELGFNKHLLNSELDQGVLVFDPIFDLESNPLKVLELDDLILDIKLLWNRPDGNSYLVLANELAAFFKTDFSLINKEISGKFYSELKIINKTDSKIFALEIQKLPKLALVDIFLLLKSEVKIGNLAQNFSNFILIYTGQPSYCLQLEKHQQKVELIEQKVKIKYEPDTISSYHFLNQEKKPLLIPEFSDQIIMENNSFFLIMPKFNLLKVKQIKQFLKKNSLKLTQLGKNYNYGTTFIALSFLNFFLEDQKIDFSWPINFDKSLISKKTFLDLNYNELKEILGLELSQEDISKTNLILEKIGYNFDNTSFSPPFYRVDIEFFADYAADFLRFYGLEKLKDCKLEQVKSKIPNPDLEPVKLKTLGYYETNSFLLISKEEDFNPLELKSQDLLTFPSQEHTKIRYSLAWQLAKITKYNQKRKITEINLYEKGSIAGWNHSLALASTIYTSEDLKKHLKILYNYDFDFLPADSEFLNPEKSQFIYLDNVLVGWLGQVAEKYNYENVNFLEILLSKVEKIPKKEGGKIKFRPYDNSQLKYRDITLSLPMKDIPDPYLKVIQKIPEIFSVKLINYVIINNQQKITYRITGPDQVCAEIDKFYK | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 83364
Sequence Length: 718
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q6KHC8 | MIFSYKHLKKLANLNEISFEDVIKAFNLIGFEVEETKEIRHVENIKYGKVLKIYKNENSDNLTVCEIQFKDKIRIIQTTAKNVEINKYVMAFIPGSKLANNLIESKLLKGIISEGMLVGFDEMLGFEIKLVPKELSKNVIVLDEANLNEDPIANLELHDYLIDLAILPNRSDAISYLVMAKELAAFFGTKIDNDLICLKNLRVSKINSNLEGIFVKSKTLELKLYDKYLLLKSHLKLTNTYKDLENLILIHTGMPIHFLNLKSLEKVNIVSKSSSLEIANRTLKIDNNLVIEKSREIIAIPYLETQKEFEIKDSQKEFFIFMNILSPKEVRKTIKTLKLESSQIKQATKTISHGMQLNAIQYMQSLFEEIEIVNINLNLKPKEILFDHTFINRIAGFEIVKEQKFINAKKSLEILGFKFFEDKILVPAYRHDYTGPYDVIEELFRFYGYDNFPILQPEIKPFKIQKKYDFKFSLASKNYNEIKTYSLVAKEDNNFDPFNFKTEILMKTFPSEKRRIIRNSQAFSLLEIAEYNIKRKLEKINFFDFGMINEGKRALIFASNEKSFNEIKKDLFSLFSYKFELRKTKNNYLHPNASAHIFYENKLIGWMGKINPSLKISDLIFVEILLDEFNISKNQFKEYNFDPLKFRDITFSIEKNQSIDTYLKELKKIKNIFEVQIIDKFEKNEKLNITVRILLEDDAIKNLDEAILKNSWN | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 83486
Sequence Length: 713
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q0W0X4 | MATVTLNYPDLVKLIGIDLSLDKVREVMFELGSETEDIQGDEVTFEVTSDRADLLSEEGIARMLRAYYSIETGFRIPKLQPSGYKLIVNREVEPVRPYVTGAIVRNVQFTDESIKSLMHLQEKLHGTFGRKRKKGAVGVHDLSKIKGREIHYRAVPGDSVKFVPLQSDELMTLSDVLARHPKGIDYRYVLEGKNLMPIITDDEGIFSFPPIINSKRTEVTLNTHDLLIELTGEDLRTIDYMLNIVLYSLDLRGASIYSIDVVYPDETLHRPDFNVRNIDIEVDYVNRVLGLELTAPDIKALLERMGFKVAETGSDYLIVEVPPYRADILHKRDVVDDVGRAFGYNNITPSYPNTPSVGKLTEATKLGDAIRNTMIGLGCQDTFNFILIGKDEVFGKMNLPDDGTAVEISNPYAEQYNIVRTSLIPSLMIVLSNNLHRDYPQNIFEVGTVAHLDSAENTGVKEIDHVACTLCYAKAGFNEIKVKLQSLCANFGKLDELKTVAAEHPSFIPGRCAEVRIGDKKVGIIGELSPVVLKSWGIEMPVAAFEMEIAALK | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 61711
Sequence Length: 553
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q2FLL1 | MPVVSLPYKYLERLCGIDRKTIIDHLPMIGSDIERILEDQVDVEFFPSRVDLYSTEGVARAMRGFLELETGEEVYPVSPSSITFSVDENLKEVRPYIGSAVIRDIQLDNEAIISLMGVQEALHWVVGRGRAKVAIGVHDLDKVTPPFRYYGAPVTRSFIPLDYDREMTLTEIMEEHPKGRDYSHIVKDKPVMPLIEDANGNVLSFPPIINGELTRVTESSKNLLLDVTGTDERAVMTALRVLCTTLITAGGRCESVTVNGVVMPDLSPALRNINVTSCNKLLGTSFSADEIATILKKMRYGAEKSGDSTVSIRIPCYRADIMHEWDVYEDVAIGAGFGNLEAELPATFATGCEHPIIALASAIRDICSGLGYLEVMPFTLSNEDVMYTRMQREPDPKALHVLHPISEEQTLVRTDLLPLLLDLLRMNKRRELPQRIFHTGDVVSSMQTYQKLALASTHPGADFSEAYATTDALMRELGISYLPAESADPAFIPGRAVDIMVDGKKMGVFGEIHPGVLNKFDIDQPVIGIEIDLHLLFPGQKETKS | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 60393
Sequence Length: 545
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q58508 | MPTINVKKADLERLVNMPLEDEFIEEKFPMMGVEVEGIFEEDGEKIIQFSINPNRPDYLSAEGLARGFRGIIGIETGLKKYDIESSDVKLYVENVETRPYIAMALVKGVIVDDYVLESIINLQEKLHWVMGRDRKKVAIGIHDADKVKPPFYYKEVSGDGIKFVPLNSDEEMTPREILEKHEKGIKYAHLIKDDKFPIILDSEGDVLSMPPIINGELTRVTTETRNLLIDVTGTDKYAVEKTLNIIVTALAERKYGKIHAVEVIKDNQSTIYPNLKEDVLETTSEYINKVLGANLTPGTIINYLRRCRLDAQFVDNKIKVFIPAYRVDIFGEIDIAEEVAIAYGYNKFSGEYPIIGTIGELNQLEKKCDFIREIMVGFGFYEVINLMLSNDEVLFKKMRIEDNNYIEVLKPASIEHRIVRKSILPLLMETLRINKHKELPQKIFEIGDCVVIDENAETKSRVVKKIAGVIVDNETNFNEIKSYVEGLLRELKIEYELDNFEHPSFIKGRCAKILKDGKIIGYFGEIHPEVITNFELEFPVVGFELEIE | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 62697
Sequence Length: 548
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q8TX56 | MPVVTIHYDKLVKILGREVSFEELAHNLIPMLGSDVERIDEREMVIETEFFPNRPDLYSVEGVARALKGFLGIETGIPEYNVRRSDVEARVEESVLDARPCLAVAVVRGVEFEDERDLEHLMEFQEHLHWVIGRDRKKAAIGIHDFEAVEPPLRYFLADPNDRSWAFEPLDHPGEEMTPAEVLRRHEKGRQYAHLVSDGAPILADEEGVISFPPVINSERTRVTQDTTDLLIDVTGTDWRSVLDALHVIVCNLAERGAEILTVEILGAYERTTPTMELDVWDVPVSEARKLLGIDLSGEQLEELLERARHGAIFVPEGERELREYPLPDVYHIEADWREIPPILYEEDVVRVFVGPRRTNILHEWDLIEDAGIMYNYDRFEPTVPDFYTPSRADREREFINVVRDTLARMKFVEVNSLTLISPEENYRKMRLEPDGRAVKLANPIQKEYTIVRTWILPSLMRFLADNKHRPYPQRVFELGEVIERDEDAETGAKDRWKLALAIAGPGVGFSEIKSVVEALLRELDVTGWEITERKHRSFINGRCAAVLADGRELGFFGEIHPEVLTEFDLEVPVVGGEFDVAALRTAAGW | Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 67512
Sequence Length: 590
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q4L5E4 | MLISNEWLKDYVDAGVKVEDLAERITRTGIEVDDMIDYSKDIKNLVVGYIQSKEKHPDADKLNICQVDIGEEEPVQIVCGAPNVDAGQHVIVAKVGGRLPGGIKIKRAKLRGERSEGMICSLQEIGISSNVVPKAYENGIFVFQTEVEPGTDALTALYLNDQVMEFDLTPNRADALSMVGTAYEVAALYQTEMTKPETQSNETSESATNELSVTIDNPEKVPYYSARVVKNVSIEPSPIWVQARLIKAGIRPINNVVDISNYVLLEYGQPLHMFDQDHIGSKEIVVRQAKDEETMTTLDNNERKLVDTDIVISNGQEPIALAGVMGGDFSEVTEQTTNVVIEGAIFDPVSIRHTSRRLNLRSEASSRFEKGIATEFVDEAVDRACYLLQELASGEVLQDRVSSGDLGSFVTPIDITAEKVNKTIGFNLSNDEIQSIFRQLGFETTLKGETLTVNVPSRRKDITIKEDLIEEVARIYGYDEIPSSLPVFGEVTSGELTDRQHKTRTLKETLEGAGLNQAITYSLVSKDHAKDFALQERPTISLLMPMSEAHATLRQSLLPHLIEATAYNVARKNKDVRLYEIGRVFFGNGEGELPDEVEYLSGILTGEYVVNAWQGKKEEIDFFIAKGVVDRVAEKLNLEFSYKAGKIEGLHPGRTAIVSLEGQDIGFIGELHPQVAADNDLKRTYVFELNYDAMMQVAVGYINYEQIPKFPGVTRDIALEVNHDVPSSELKQIIHNNGEDILQSTLVFDVYEGEHLEKGKKSVAIRLNYLDTEDTLTDERVSKIHDKILEALQAQGATIR | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 88876
Sequence Length: 800
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q5XCX3 | MLVSYKWLKELVDIDVTPAALAEKMSTTGIEVEGIEVPAEGLSKLVVGHVLSCEDVPETHLHLCQVDTGDETPRQIVCGAPNVKAGIKVIVAVPGARIADNYKIKKGKIRGMESLGMICSLQELGLSDSIIPKEFSDGIQILPEEAVPGDAIFKYLDLDDHIIELSITPNRADALSMRGVAHEVAAIYGKSVSFPQKNLQESDKATSEAIEVAIASDKVLTYASRVVENVKVKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDYDKFEDHKIVARAARQGESLVTLDGEKRDLTTEDLVITVADKPVALAGVMGGQATEIDGNSQTVVLEAAVFDGKSIRKTSGRLNLRSESSSRFEKGVNYATVLEALDFAAAMLQELAEGQVLSGHVQAGQLPTEPVEVSTSLDYVNVRLGTELTFADIQRIFNQLGFGLTGDETRFTVAVPRRRWDISIPADLVEEIARIYGYDKLPTTLPEAGGTAAELTPTQALRRKVRGLAEGLGLTEIISYALTTPEKAIEFAVAPSHLTELMWPMSVERSALRQNMVSGMLDTVAYNVARKQSNLALYEIGKIFEQEVNPKEDLPNEVNHFAFAICGLVAQKDFQTQAQAVDFYHAKGILDTLFANLNLKVQYVPTKDLANMHPGRTALILLDEQVIGFVGQVHPGTAKAYSIPETYVAELDMAALEAALPSDQTFVEITKFPAMTRDVALLLDREVSHQTIVTAIESAGVKRLTKIKLFDVYEGATIQAGQKSMAYSLTFQNPNDNLTDEEVAKYMEKITKSLTEQVGAEVR | Cofactor: Binds 2 magnesium ions per tetramer.
Catalytic Activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)
Sequence Mass (Da): 87519
Sequence Length: 801
Subcellular Location: Cytoplasm
EC: 6.1.1.20
|
Q8RH45 | MTFQEIIFSLQQFWSSKGCIIGNPYDIEKGAGTFNPNTFLMSLGPEPWNVAYVEPSRRPKDGRYGDNPNRVYQHHQFQVIMKPSPTNIQELYLESLRVLGIEPEKHDIRFVEDDWESPTLGAWGLGWEVWLDGMEITQFTYFQQVGGLELEVIPVEITYGLERLALYIQNKENVYDLEWTKGVKYGDMRYQFEFENSKYSFELATLDKHFKWFDEYEEEAKKILDQGLVLPAYDYVLKCSHAFNVLDSRGAISTTERMGYILRVRNLARRCAEVFVENRKALGYPLLNKK | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 33950
Sequence Length: 290
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q74FM8 | MTFQDLILALQGYWAQQGCVIQQPYDTEKGAGTFNPATFLRVLGPEPWNVAYVEPSRRPTDGRYGENPNRLQHYYQFQVIMKPSPMNILDLYLDSLRAFGIDPAKHDIRFVEDDWESPTLGAWGLGWEVWLDGMEITQFTYFQQAGGIDLKPVSSEITYGCERIAMYLQGVDNVYDLEWVKGVSYGDIHHRTEVEFSTYNFEEADVDMLLTLFTMYEKECVRLVERGLVLPAYDFVMKCSHTFNLLDARGAISVTERASYIGRVRNVARLCAEGYLKLRESLGFPLLKGGRK | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 33479
Sequence Length: 292
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q74FM7 | MSKELFLEIGTEEIPAGFLPKAMADMEAIVTKELENARLAFGEVKTFATPRRLALVVKGLPTVQPDAEITALGPARNIAFGPDGTPSKAAEGFARGQGVDVASLTLVSTEKGEYVAAVRKESGRPVPDLLAEILPRLVGGIPFRKSMRWADLDVRFARPIHWIVALFDGVVVPFAFGNVQSGNVSRGHRFMANQPFPVRDFAHYLDECERHFVIPDPERRKETIRREIHRVAKTAGGHLLPDEGLLDEVAYLVEYPSVVHGTFSPDFLKVPREVLITSMRSHQRYFSIVDDAGKLMPGFITINNTLTEDPSVVVKGNERVLRARLSDARFFFEEDQKVKLETRVESLKNVVYQQKLGTSYEKMERFRALAEGLADLLNPAVKAKTSRAAFLCKADLVSGMVGEFPEVQGIMGREYALLQGEDAEVAAAIAEHYLPTQAGGDLPASDIGAFVSIADKLDTICGCFGVGLIPTGSADPYALRRSALGIINIILDRGCRLSLEGEIGKALELLSAKLTRPAAEVMADVLEFFRGRFVNLMADRYPADAVDAAIAAGFDDLVDAEARIGALAAFKGRPDFDSLAVAFKRVCNIVKDGVDQPVDAALFQEPAEGALFAAFQQVRADVEARTASGDYLAALTGIAALKGAVDDFFDKVMVMAEDERVRTNRLALLTGIARLFGGVADFAKIAA | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 74631
Sequence Length: 687
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q2SQY0 | MNHQDFLVEIGAEELPPKALRQLAEAFAQGIRQRLEKAQLSFSELTWYAAPRRLAVHVSGLAEKQPDLEVEKRGPALQAAFDAAGAPTKACEGFARSCGTTPDKLEKLETDKGVWLVFRSKQAGAPTTGLLPAIVEESLAALPIPKRMRWGARRTEFVRPVHWIIMLFGEKVIDCEILGLKAGNTTLGHRFHHPAPIEIATPANYKDALKNTGYVMADFEERKALIRQQVEAIAKQTSGMAVIDEELLEEVASLNEWPTALMGRFEDRFLEVPAEALISTMKGNQKYFHVVDAEGRMLPYFITVANIESKDPQQVIDGNERVIRPRLSDAAFFFSTDKKRTLASRLEDLKPIVFQQQLGTVYDKAIRVGKLAAKIAAKIDSNPEWAQRAGELSKTDLATEMVMEFPELQGTMGRYYAAIDSEPEEVSMAQEEQYLPRFAGDQLPTTLTGCAVSLADKLDTIVGIFGINQPPTGAKDPFGLRRAALGVLRILVEKKLDLDLAECVQWAQELHGDLPAENLETAVVDYMLDRFRAWYEEAGVPTEVFLSVLARRPTKPVEFDQRVLAVAEFLKLDAAQALAAANKRVSNILSKEQVDISAESANPELFTEEAEKNLFRALQEKSESARPYIEQRNFTQALQQLAELKDVIDLFFDKVMVMVDDPAIRSNRMTLLASLRHVFLQVADISLLQNKA | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 77189
Sequence Length: 692
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q9KD48 | MSKRDFLLEIGLEELPARFVSDGEKQLADKVESFLKEQRISFEQISSFSTPRRLAVLVIGLAEKQADVEEESRGPAKKIALDESGNWTKAAQGFARGQGVSVDDLYIQEVKGTEYIFAKKFVAGQETASLLPELKELITSLHFPKNMRWHTYSLRYARPIQWLVALYGQEVIPFEITGVAAGLETAGHRFLGENVTIDEPTLYKEKLLQQYVMADSEERKKAIRHQIQSIMEEKDWVIPIDEDLLDEVTNLVEYPTALFGRFDEAFLSLPNEVLITSMREHQRYFPVKNQAGELLPYFVTIRNGDHRHLENIVKGNEKVLRARLSDAAFFYGEDQKLNIDEANKRLDQIVYHEELGSIGDKIKRVKVLAASIAEKLGVTSQTLQAINRVAEICKFDLVTQMVGEFPELQGRMGEVYAEIAGEPPEVAKGIVEHYLPRFAGDQSPSSVQGTVVSLADKLDTIAACFGIGLIPTGSQDPYALRRQAAGVVQILLDHELDLDVDELLLETVEQLQEKELLTVPESEVVKQLREFFALRVKTKLQDEGVRYDLTDAVLASGISNVPVVFKKAKLLVSKVNTPEFKELVEGLSRVTNIAGKAEKNVAINPDLFEKEEERVLYEAYVQTKDLVQGALASGDVSAAYAALEQTIEPIHQYFEHVMVMVDEQVIKENRLALMHAFAGVIGSYANFQEIVFK | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 77834
Sequence Length: 693
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
B8CXH5 | MARDLLFEIGTEEMPAGLIGKIRSDLKDLAINTLEDKRLDFKECKVFSTPRRLVLFVKELAEKQEEKREVVKGPARSIAFEDDGTPTRAAKGFSRAQGVEVDDLIIKDDYVYVEKIEQGQDTAGLLKDILPGLINKLPLPRSMRWADYNFKFIRPIRWLLALFGEEIISFSMAGVQSGAYTRGHRFLVKDRLEVKDPDHYFDVMEKGYIIVDHNKRRELILKQIREIEKEIGKVMVEDDLLTEVVDLVEYPTAFYGKFDRSYLELPDDVLITSMAEHQRYFPVIDEDGSLSPYFVGVRDGIEDYIEEVRYGNEMVLRARLADARFFFEEDLKVSIEERQKELEEIVFQEDLGSMMDKVKRLKQLVIQIGKSLNLKESQLQSLIRAAELSKNDLVTEMVNEFTKLQGVMGREYALINGEDEEVATAIYEQYLPRYSGDRLPQTLYGRILSIADKIDNITSHFSLGMIPSGSQDPFALRRQANGIVNIIIDAQLPLKLSSLLNWSIEVLEPGDKDFVNEEKSFLLQRLETILDERGIRYDIINSVVRVGDDDPNNILSRAEAVMSLRKENPDLFVDLIQGLVRARNLASKGEGNNDINPEYFECREEKELYDIYRKIKDEIQRQFKKKNYLSGLKKLVDVKEPVDNFLDNVVVMVEDERIKNNRLALLQEISNLVSGVMNISEIALDD | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 78940
Sequence Length: 686
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
A3CQ05 | MVKNLLVELGLEEMPAYVVTPSMKQLRDKMGAFLTDHRLTFEKIEMFSTPRRLAVRVVGLADKQSDLTEDFKGPSKKIALDADGNFTKAAEGFVRGKGLTVEDITFREIKGEEYVYVTKEEIGRPVEEIIPAVTEVLQALTFPVSMHWANNTFEYIRPVHTLTVLLDEQAFDLDFLDIKSGRTSRGHRFLGKETEISSADSYEDDLRAQFVIASPLERGDMIVEQIRALEEEHGVSIEIDENLLNEVLNLVEYPTAFLGNFDAKYLEVPEEVLVTSMKEHQRYFVVRDAEGKLLPHFISVRNGNAEHLENVIKGNEKVLVARLEDGEFFWREDQKLAIADLVEKLSNVTFHEKIGSLAEHMERTGKIAALLAKEAGLDANETADLARAAAIYKFDLLTGMVGEFDELQGIMGEKYALLAGENAAVAAAIREHYMPTSADGELPDTKVGAVLALADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDKFGWNIDLAQLLGRLYGLKFDSLSYDNQEAVLDFFRARVEKMMDRSTPKDIVTAVLQSTNFVVRDLVETAALLAEKAQEDNFKSAVESLSRVFNLAEKAQGQTAINPALFENQEEKDLAAAIEKVELTSDLAANMDQLFALSPVIDAFFDHTMVMAEDEAVRNNRLALLASLTAKAGQLAQFNQINTK | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 75614
Sequence Length: 679
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q2LVI9 | MSNELLLEIGTEEIPAAFLPKALQDMSSMIRKALTEARIPFGQVHTFGTPRRLCLAVADVAEKQEDQVIEKLGPARRVSFDADGNPTKAALGFAKSQGVDISEIGTMQTDKGEYICISRHISGKSTVSLLSEMLSRLITSLSFKKSMRWGNLDFRFARPIHWILALYGGEVIPFRIENIESGATSRGHRFMHPEAFPVSNLQEYLARTREHFVIVAPEERKRIILEEARKAAAAVSGRVLENEDLLETVTYLVEYPTIVCGSFDRKYLELPKEVLITSMMSHQKYFPVVDQEGRLLPFFITINNTLARDPAVVTRGNEKVIRARLSDAQFFFEEDQKIRLDDRVEGLQQVVFHTLLGTSYEKVQRFRKLAGWIADRIDPSLKNRVNRSALLAKADLDTQMVGEFSELQGIMGREYALLAGEDPTVARAIYEHYLPLTAGGDLPQTHEGAIVSIADKMDSIAGFFGVNLVPTGTADPYALRRQALGVINIILDKKYPLTLDDLVDECISILEEKLKRPAEETRKDVIEFFRGRLENMLISQGHPHDVVSAVLAAGFADLVQVIKKIEAMESFKAHPAYEPLAIAFKRAGNILKEFRNGRIDPALFSAAEENQLYSTLLEARARVVKALEKDDYPAALLELAALRQPIDHFFESVMVMVDEENIRFNRLSLLEALFSIFRRIADFSRIVTES | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 77603
Sequence Length: 690
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q0AWT6 | MAQDLLLEIGVEEMPSAYMPRVLKDLKDLAQKNLAEARLSCGEVLTLGTPRRLCLWVKEISEEQEDSLLENRGPKKSIAFDANGNPSKAGLGFARSQGVDFRELQIREVSGVEYLFAIKKEKGQAAEQILPGLLLKVIHSLSFPKSMTWSYYQTRFARPIRWLLAIFGDKNVEFNIENIKSANYTYGHRFLSTGVLLVTSIDDYFRVLREHYVILDQAERKKMIWQQVQKVAGEAGGKAMENEELLEEVAFLVEFPTAFYGEFSPSYLDVPPEVLTTSMIEHQRYFPVYNNEGRLLPGFVGVRNGTDYCLDIVRAGNERVLKARLEDALFFWNEDSRKSLEEMSAKLKNVLFHERLGTLADKVLRLQKLALFIGQQTGLGQPEKLQRSALLCKADLMSNMVYEFPELQGIMGRYYASGSAEEPEVAEAIFEHYLPRFAGDKLPSSAGGIVLSLAEKMDNLMGCFSIGIKPSGSQDPYALRRQALGLVNIILDKKLSIDLKLVFEQAYLGYKDIDLEKSREDSVKELLDFIYQRMRGVLLDNGISYDVVDAALSRPSFDLFETYYRAFKLQEFKKSPVFEDFMVVYNRVHNLSRKWESEEIDLDLLVDESEKNLCQKLPGLQEDIKKSLIAQDYTRALELLAALRADIDQFFTAVMVMVDDERLKAARLGILKSIANMFNSIADFSKIV | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 78244
Sequence Length: 688
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q9WY60 | MRTALLEVGLEELPASEFHSILKQLEEKSAELLKAYRVSSGSVEVFVGSRRFGVILKNLPERQEDFTEEKKGPPLNVAYDENGKPTRALEGFLRNNNASLENVVHREGYVYLSRVVEGKPVEEVLPDLFRDLVLGLNFRKPMRWGSGEHEYIRPVHWIVAMVDGRVLDLEIFGLRSSRISYGKRYHAGSIEIPDSERYYESLKKGFVISSHLERKKFVLEQIDEFEKRSSMKIERDEELIEEIVAITEYPRIVVGQFDRKYLELPEEIIVTAVKHHQRSFIAHKGTLTNTFVAFQDGPQPPENVVKGYERVINARLEDARYYFQKDLETPLEKMNEKLKEIVFQEKLGTLYDKVERIKKISQRLCEDLKLPGSFTQKVLEAASICKADIASKVVYEFPELQGVMGRIYALREGINEEIATAIEDHYSEEPQTVIGSILGIADRIDTIVGNFAIGNVPTSSKDPYGLKSKADTIFRIIRKNEWDISLEELLTFASSLVGYRLSEELETFFAGRFYQFLINELGISFDVARAVNHLWKKPLRGILSAEALQEISEKPEFQDLFVGFERVHNITKNHDSTKFDGALFEKEEEKKLMNKFYEVKEKVLKALERLNYREALQYLIELKPYIDEYFDNVFVMVKRDDLRVNRLSFLKNIDELFMMVGDMTYLVKRSQV | Catalytic Activity: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Sequence Mass (Da): 77813
Sequence Length: 672
Subcellular Location: Cytoplasm
EC: 6.1.1.14
|
Q8UHK4 | MSEKAKKPQKLKARLPRGFVDRSAADIHATNEMVDKIRRVYELYGFDPIETPLFEYTDALGKFLPDSDRPNEGVFSLQDDDDQWMSLRYDLTAPLARHVAENFNEIQLPYRTYRAGYVFRNEKPGPGRFRQFMQFDADTVGAAGVQADAEMCMMMADTMEALGIARGDYVIRVNNRKVLDGVMEAIGLGGEDNAGRRLNVLRAIDKLDKFGPEGVKLLLGPGRKDESGDFTKGAGLGDEQIEKVLFFVGIKDYAASADDLAKLVAGTSKGEEGVDELNTIGALVSGAGYDATRIKIDPSVVRGLEYYTGPVYEAELTFDVTNEKGEKVVFGSVGGGGRYDGLVSRFMGQPVPATGFSIGVSRLMTALKNLGKLGQVKPLAPVLITVMDGDVESMGRYQRFTQALRAEGIRAEMYQGNWKKFGNQLKYADRLGSPIAIIQGGDERAEGVVQIKDLIEGKRLSGEIEDNASWREARVAQVSVPEAELVAKVREILEHQAEDVRRAAEGR | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 55728
Sequence Length: 507
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
A8MGM7 | MLTNGPRGTKDVLPSEAYKWHYVEGVFKEVAKRFGFEEIRTPVFEHTELFERGVGDTTDVVEKEMYTFLDRGGRSITLKPEGTAPAARSFIEHKLYADTQPTKMFYITPVFRYERPQAGRFREHHQFGVEAFGASSASVDAEVINLAMSVYEAFGVKKLELRINSVGCPKCRAEYNKVLRAFLSSRLDQLCGTCQNRFERNPIRIIDCKSDSCQAQLTDVPLMMDHLCGECQDHFEELKKYLEASGLHYVIDPRIVRGLDYYTKTAFEIITEEAGKKGTVCGGGRYDKLVEDCGGPSTPGVGFGMGIERAILALEDQGIEIPKPEGLDVFIVTMGEKASYEGFKLLTALRRAGFSGDKDHLDRSVKAQFKYANKVNASYTIIIGENELEKGIAKLKNMANSEEIEIELKDITKLKEILSGR | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 47257
Sequence Length: 421
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
B2KBC0 | MTKLVRGFRDIFAPESNNFAELEACARRVFTLAGGTEVRIPTLELKELFIKSTGDTTDIVQKEMYAFEDAGGRVLAMRPEGTPGTVRAYIENNFAQTAPVQKLFYIGNMFRAERPQAGRYREFEQIGMEYIGNPSPAADAEIILMIKDIVTSFGVKNYGVKINSLGCQECRPAYKQELINYLKKDFDTLCEKCKDRLEKNPLRVLDCKIDGARFKENAPKQKLCAACENHFNEVKTFLQGRIDYIIDPSLVRGLDYYTRTVFEFQAGDSAQNAIAGGGRYDSLVKSMGGADMPAVGFAMGVERTIAARGETKDNKQNKIFVVSLDKNCNAKAFEIMSLLRSAGVICDGGLFDKNLKAQMKQADRTKSSFALLLGADEFEKGVVTMRDLSSGEQQEIKFNDILNKVGKIRL | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 45729
Sequence Length: 410
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
B1H0I8 | MNYKAPRGTHDIFGINASGMSWLEQKAKVIFKRHGFEEVRTPVFEDAALFMRSIGQTTDIVEKEMYIFEDRKKRKLALRPEGTASLVRAFIEHRMDVSMPAGRFFYMGEMFRYERPQAGRYRQFHQIGAEFFGSSSPAADAEIIILAQHLLSSVGINEMNIYINSLGCEKCRPFFRETLVKYLGSVRDLCEDCLRRLEKNPLRILDCKTDSNKFTAVPRMSDYLCNCCKDNFSLTQSLLKSVGYNYTVDERLVRGLDYYTKTVFEIRSDAVGSQCALAAGGRYDNLVGELGGQDTPAVGFALGSERVLLAVQKTGFFGSFQESEKIFIAVADQELFSEAFSFAVKAMRNGLKGNKNISVFGPINGKSLTSQLKFADKIKAVKTIVFARTEFEYGKFLMKNMKDKTQTEFLISEF | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 46907
Sequence Length: 414
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
A5F9R5 | MASKPSIPKGTRDFSPAEVSKRQYIIQTIKANFEKFGFQPIETPSFENSDTLMGKYGEEGDRLIFKILNSGNFFYNKSKIELPESIEELQLNSAEKITLEQRIELNKFTGKISEKALRYDLTVPFARYVVQHQSEIEFPFKRYQIQPVWRADNPQKGRFREFFQCDADVVGSKSLWQEVELVQLYDTVFTSLGLEGVTIKINNRKILSGIAEVIGASDKLIDFTVALDKLDKIGEDGVKKEMIEKGISEDALVKVQPLFNFSGTFADKIAQLSDLLSSSEEGMKGVEELKFICDNVADLGLSTAVLDLDVTLARGLNYYTGAIFEVAAPKTVAMGSIGGGGRYDDLTGIFGLKNMSGVGISFGLDRIYLVLEELQLFPETVAATSKAIFLNFGDKEALYASKAIQKLRQENIKVELYPDNVKVGKQFQYADKRLIPFAVLVGDQEINSNSYALKNLVTGEQVSVDFEGLKKTLLG | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 52941
Sequence Length: 475
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
B0TWR5 | MSKLTIIRGFNDILPQESCKWQFLESKIKSILDKYNYDEVRLPVLEKSELFHRSVGETSDIVSKETYDFVDRSGESLTLRPEGTAGCVRMVIENSLANRGQTQKLWYSGPMFRYERPQKGRYRQFYQLGVEAYGYDNIAIDLEILTISWNLFRELGISECVKLELNSLGSSSNRQEYTKALLEYLKPYHAQLDEDSIKRLDKNPLRILDSKNEQTQQVLANAPKLIDFIDEDSLTRFEQTCEYLDNLGVNYQVNQKLVRGLDYYSGLVFEWVTDRLGAQAAVCAGGRYDNLIESLGGQKAGAIGFAIGLERLLLLLESEGKLPIEDDKSDVFFILDNNQLHRSLLLVENVRQELPALKIDMDLKFGSFKSQFKKADKSDAKIAVIIGQDELLQQAVGVKYLQQDKQQEQIPLNKLINFLEKIAI | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 48526
Sequence Length: 424
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q8EWB8 | MVIKKPRGTYDLFGEEIEVFNKINDVLKTISNTYNCHEIKTPIFEHKELYIRNIGESSDIVTKEFYDFKDKSDRELALRPENTVGVIRSVVENKLLYTNPFPLKFYYLGPMFRYERPQSGRNRQFYQFGIEFIGVKNILNEIEGILFALDILKKLNITNWKLKVNYIGSIETREKWINSLKKYFNKYKDELSEDSKNRIEKNPLRILDDKVDGSKSFVKSCPKIEEFLTKEEKEESDNFIKCLKTIVNEFEFDSTLVRGLDYYSGPVFEIVSQSNKLTGQSTIIGGGRYTKLTKELGDNDYICFGFALGMERLMLAYRDENQFLSNNSVDVYIASIGSVESELVAMNFANQLRNLNYRVEVNFDLKKIDKQFKNSNKYNPKIILIYGDEDHKNKQVTLKNQKTLENKVIKLNELNNKIKEFFESDK | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 49905
Sequence Length: 426
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q6F199 | MKTNKNKTNIKMIGFYHFFYFVKPYYLLINENVIIFKAKGDFMIQKPRGTQDLFLNNSKEWNAVEEKFRKVLNLFNYGEIITPMFESKELFVRGVGDSSDIVSKEMYEFTDRKGREYVLRPEGTAPTVRALIENKLYIQENLPYKTFYIGPIFRYERPQAGRYRQFNQLGVETFGIDSISHDVELISLGQSFLKELKINKDVIVEMNYLISGNERKEYELELKKYLNLFDDLCSDCEIRINKNVLRVLDCKIDGNKFAEAPKMTLFASQENKERLNKTFDQLKQLGIEAKINFNLVRGLDYYTGLVFEFKNIKTDQAIIAGGSYNNLVEELGGPNLPASGFAIGIERIMMILSDQEIKVADEDELDLFIIPLSDDAQFLTNKLLLEARTANLKVDTNWNIKNLKAGFKSAERLKSKNIVIIGENSINSDIYAIKDQKSGETKELKFKDIVKYLKGEK | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 52849
Sequence Length: 457
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q601R3 | MKKKLNLCPKGTYDFFGQGAKIFIDVRKVFFNQAKKFNFSYIETPIFEYANIFLTTNQIADIVSKELYKFFDKSGRELALRPEGTAPIMRSVAQHKLFQTEKKFFYFGPMFRYENPQKGRFRQFYQAGFEIINYKKDSLEFQILEIILLIKSIFKDLGINEYEIKINFLSNLTTRNIYKKNLAQYFEKFSDKLEPISKIRIKKNPLRILDDKIEQEKEFVKLAPKINTFWTMEDKNIFNRITSILEEFKIIYKVDYNLVRGLDYYDDFVFEFIDTSQTLGTKLALVGGGCYNNLPTKFGLNNFKSIGMAFGIERLIEIIKSKKNIKEQNLDFFLLSFTDKEILLNFKLAKILRKENFLVDLNKTPFSVSKGFQLAKKSGAKFVFFFEKNQAKNYISLKNLQTGKNEQILYTEINFEYLNSIIKASENA | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 50401
Sequence Length: 428
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q6KI17 | MMWYNLTIKQLKNVRNFMIQKPKGTSDFFLEKADLFQYILDTFRKEAELFNYSYIQTPILEFYDLFYRSVGETTDVVSKEMFIFNDRSERKMALRPEKTAGVIRSLVENKLIFNAENKFYYYGSMFRYERPQKGRYREFTQIGCEWIEDNSDFSDFEILLFASKFLGNFNFNKVILKINNLGNKVERENYLIELKKYFYKFKDKFDEISLKRLEKNPLRILDDKEINHQDFIKNAPKLFDFLNSETVQKFNNLQNYLRKSNISFEIDYSLVRGFDYYNNLVFEFVYYDEESRSELTILGGGRYSNLIEELGGPKKDAIGFAAGVERLMILLKEKEWEKPIKTSIFVFNKDHEDLYKNFDFVYKLRKRDLVVKQNVSNFKLQKIYSKIVNEGIKFLIFFDEKLNQIIIKNLINKNFLDLTNKSQEEKINLVKKFIESENKNENNSK | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 53453
Sequence Length: 445
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q8TS62 | MTVNRPRGTRDFLPADTARRRYVESVMRNVVRNWGYSEIITPTFEHLDLFTLKSGEGIVGELYNFTDKGGRDMTLRPELTAPVMRLYVNELQPFPKPLKLFYFENCFRYERPQKGRFREFWQFGVELIGSGKSDSDAEVIALADALLKAVGIQGDMKLGNLAVIRTLLKGLEPEIVSKVMRLVDKKEYAGLESLLEEIGAEEQLKSDLFHLIHLEGKYILPKVKEIVGNIPELVGFEKTLKLLDAYGVDYSLDFGIARGLDYYTGMVFEVYAEGLGAQKQVCGGGSYQLIQLFGGGDVPSTGFGIGFDRIMEICPLVPPASKNLVLVSKPATHIEAVKVASELRNYLPVQIDLMERNFKAQFSYANTINADYVVIVGEKELEAGKLTLRDMVSGEQELLTLEEIIEKITGQQD | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 46313
Sequence Length: 413
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
A7I940 | MIQKPRGTRDFLPDEMEARRSIEAKMREAVRRFGYREVCTPEFEELELFTLRSGEGIMQEMYVFEDKGGRKLALRPEITAAVIRMYINEAKVAPKPLRWCYFADCFRYERPQKGRYRQFWQFGAELIGADTALADAEVIMLAAEALNATGVTWELKVGHLAFMKNLLADLDPAAQRRVMAHLDKKDFEGLAETLAGMRKSGLNDSLTALVECRTLAEAFEIAGTIPEKERVEQTMGILDASGVRYSLNFGIARGLDYYTGMVFEGFAENLGAENQILGGGAYRLAHLFGGDDVASCGFAIGFDRVMVSLGEVFAAKDTIAGIVCTDEGRSFALSVAREFRAAGIRAEMDLMGRGLGAQLAHASKTADFAVVIGKREADAGQVTLKNLHSGEQKTLDPAAAIAEVKAHGAR | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 45048
Sequence Length: 410
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q58406 | MIVMFQKPRGTRDFLPEEMKKRRFVENKLREVFERYGYKEILTPTFESFELIAKKTGEEIRKQLYVFKDHGGREMALRPEMTSPVVRFYLNELKNLQKPLRLYYFANCFRYERPQAGRFREFWQMGCELIGCKEPLADAEVLNLAMDGLINIGLDFDVHIGHLGVLKGVLEKFNVSEEEEVKIRRLIDKEDYDNLKIYLTQILGEEKKELIFEILKFKGSREVLDELKEILKDFPKSMEAINNLEEILEFVIHDKYTINLGIARGLDYYTGMVFEIYGKKGAKQICGGGRYDNLIETFGGEPTPAVGFAYGFDRIMMNIDDLDIEEESILIIPVKKDKELIKKSLIIADKLRKAGKIVELEIMGRKLRKALDYANSRGFKKVIIVGEKELNEGKVTVKDMITGEQKLIGIDELTNF | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 48322
Sequence Length: 416
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q8TV61 | MGVTLMKVERPKGTRDFTPEEMRARRWLERYLLDVFRSYGYEEVLTPTFEHAKLFEEKSGEEILEEMYVFKDKKGRKLALRPEMTAPVVRFYNAELKTRPHPLKLAYIVNCFRYEQPQRGRWREFWQAGVEVFGSDRPEADVEVIELTYRIFDGILPSGAFEVRVGHLGILRGLLEEYGIGEDVQNKVAHLVDKGELDEVKTLLPAEPAEKALAVVTARSESEVEEAVSGKERAERALENLMEISDALREAGVDHELDFSVARGLDYYTGMVFEIHVPELGGGSQCAGGGRYDDLVKELGGPDVPAVGMAIGFDRLLLAAELYDRIPDGVEETRALLIPLVRSGKIWEIAAKLRKLGWVVNVEVSGKHIRKALSLADSLEYDYAVIVGERELKEGYVSVKNLKTGVQEEVPLDQLERAAEV | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 47470
Sequence Length: 421
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
O43011 | MFVFTKNLFTTKFSSSLLNWRFLRTMADSLVDINERITSQGNLVRSLKSQGASKEDIDKEVAKLLQLKNLKLGGSEVSGKKKDTSFTLKTPKGTKDWCDKDVVLREHIFSTVTEIFKRHGGVTLDTPVFELKEILSGKYGEDSKLIYDLKDQGGELCSLRYDLTVPFARWLAMNPKVTSIKRFHIAKVYRRDQPAMTKGRMREFYQCDFDIAGNYDPMIPDSEALKVLVEALDALEVGNYTIKLNHRKILDGIFTVCGVPDDKIRTISSAVDKLDKLPWEDVRREMVVEKGLKEEVADKIKEYVLLKGDRSLLDKLEADSLLSSNSSAVAAFNDMRLLFDYLEAFGVLDRFSFDMSLARGLDYYTGIIYEAVTEASAPKIKSSAEKKKSADPEADRSNDDSIGVGSIAAGGRYDNLVGMFAAKKNAKIPCVGISLGLERIFSILRSKIPDEDIRANDVDVFVMAFGGGKEWTGFLKERMSVCKDLWANGIKAEFLYKVKPKPRQQFDAADKFDVPFAVILGQDEFAKGSVRIKQMGLKENSDEGQLVPREEMVSVLKKLLKYD | Function: Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.
Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 63305
Sequence Length: 563
Subcellular Location: Mitochondrion
EC: 6.1.1.21
|
A1S862 | MAKQIQAIRGMNDILPNQSPVWQKLEAVLRDAVAAFGYSEIRTPIVESTDLFKRSIGEVTDIVEKEMYTFEDRNGDSLTLRPEGTASTVRAGNEHGLLYNQEQRLWYTGPMFRHERPQKGRYRQFHQFGVEVYGIASADIDAEVLMLSNMLWQKLGLTEHVVLEINTLGDSDERAAYRDALIAFLEVHKDKLDEDSQRRMYSNPLRVLDTKNPEIQAILADAPALMDYLGEESKSHFSTLRELLDAVGIQYRVNPRLVRGLDYYNRTVFEWVTDSLGAQGTVLAGGRYDGLVGQLGGKDTPAVGFAMGLERIVLLLETLELAKDVPAAVDVYVTAMGDSCVPAAFAIANELRVALPGVRIMTHCGGGNFKKQIKRADKSGAALALIIGDNELAEGKVAIKPLRNDNEQQLVAREALAETIKALI | Catalytic Activity: ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)
Sequence Mass (Da): 47036
Sequence Length: 424
Subcellular Location: Cytoplasm
EC: 6.1.1.21
|
Q9NSE4 | MRWGLRPRGPGAAALATARSLWGTPRLPCSPGWQGATKRLLVRSVSGASNHQPNSNSGRYRDTVLLPQTSFPMKLLGRQQPDTELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKARSFAKAAIEKQKSAFIRWGIMADWNNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSPSSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCYMPESKYAVVKCSKSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKASPLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEGTDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIPGSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGSDIWWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLGGWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGADVLRWWVADSNVFTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQYMLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTALVEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMRDSFLGSIPGKNAAEYKVITVIEPGLLFEIIEMLQSEETSSTSQLNELMMASESTLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPRCAEVVSGK | Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 113792
Sequence Length: 1012
Subcellular Location: Mitochondrion matrix
EC: 6.1.1.5
|
Q9USL3 | MKFSYISSLPKGHNHICCKQAGRFLSSQADLKKYSESLCLPKTSFPIKPNVKGNNEKYFKSITSDLYEWQKENLNKEDSFVLLDGPPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSSLEIRKIAKDFANSAVQEQLMMFQRMAVMGDWPSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYWSSSSRSALAESEIEYDDNHVSTSIYFTFPVNSFSIDGCEYNNVKALVWTTTPWTIPSNLALSYHPEINYGLYQHNNSIYLMSDNLVPNLDFMQGAKRLASCPSDIISSFTYENPLLPKQSFPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEALDGSLEGLEVLGDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDSVKMIPPNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKGTKIPLLTVKSVSYIIEKMEVEGVDSWFNDTENNGHAQWVHPDYRNKEYIRGTETLDVWFDSGTSWTTIAPRKNKPLIDLCLEGSDQHRGWFQSLLLTYTAYQSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDVINGKLLKGKKLPYGVDLLRLWVASCDSTNDTNLGPNILTQVGESLKKWRLTSRFCLGNLHDWNTSSSVDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVKDRLYADLPNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLPDSYLNSSYQTPFHAGETHLISSLRSKVDLLDRKFLIKEYLVLQQLKYSINLLITAARENLTIKNSLEAYVVIKSKSQSLLSFLKNYSSDLPFLFNTSKVFINEIPENLKLASVTQPEVQLDYGVANISLFFSNQQKCLRCWMHTAHEDGLCDRCESVLAQLKR | Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 111255
Sequence Length: 973
Subcellular Location: Cytoplasm
EC: 6.1.1.5
|
P48526 | MKRSRLVPQHIFSIISKRYLAKHAYQKTLNLPKTKFPNRSNLEITLRELIPKSSQLVYKEQLRDFFEEFSKLNTTDEKLEFIKEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHGLPIEIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWETPYLTMDKDYEINQLNIFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIAAYVKFPLEKKSQMDLCKKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRLNSELILVETGSIDKLGLTTNSFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVTSGTGTGLVHTAPGHGQDDYLIGIQNGLEIYSPVDHQGRYQLNELPQSVRSIVRDEGDLTKGRQVLDAETAKIILCKLSDLNLLYKSHEYTHSYPYDWRSKKPVIIRATPQWFADLHDVKNLALESISRVKFCPKRGYSRLSSFMKSRNEWCISRQRSWGIPILSFYKKSEPDSVLMNSEILAHAIEKIKQKGINAWFNDKDNDMKEWLPEKYHDVAHEYCRSQDTMDVWFDSGSSWSVIKDFYEKSLKLSKLPSPLYQVCLEGSDQHRGWFQSSLLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAIIRGDENLGLPALGVDGLRYLIAQSNFTTDIVAGPTVMKHVGEALKKVRLTFRYLLSNLQKSQDFNLLPIEQLRRVDQYTLYKINELLETTREHYQKYNFSKVLITLQYHLNNELSAFYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQEVWKYIPEGWLQGQEHIDINPMRGKWPFLDSNTEIVTSFENFELKILKQFQEEFKRLSLEEGVTKTTHSHVTIFTKHHLPFSSDELCDILQSSAVDILQMDDNNNSLPTIELGSGINVQILVERSKRHNCPRCWKANSAEEDKLCDRCKEAVDHLMS | Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 115794
Sequence Length: 1002
Subcellular Location: Mitochondrion matrix
EC: 6.1.1.5
|
A0KG39 | MSDYKHTLNLPETEFPMRGDLAKREPNMLKRWYDQDLYGAIRRAKAGKPSFILHDGPPYANGSIHIGHSVNKILKDIIIKSKGLSGFDSPYVPGWDCHGLPIELKVEGMVGKPGEKVSAAEFRAECRKYAKTQIEAQKTDFIRLGVLGDWEHPYLTMDFGTEANIIRSMAKIVENGHLHKGSKPVHWCTDCGSALAEAEVEYYDKNSPSIDVRFKAVDEAGVAAKFDCAEGHTGKGPISAVIWTTTPWTLPANRGIAMHADLDYALVQVEGEHPERLILAAELVKDVMDRAGIEQFHNLGYAKGAALELLRFNHPFYSFDVPVVLGDHVTLDAGTGAVHTAPGHGQEDFVVGQKYGLEVANPVGSNGVYLPDTELFAGQHVFKANASVVEVLTERGALLHHKVFNHSYPHCWRHKTPIIFRATPQWFISMEQKGLRQRALEEIERIEQDGIKQHGQSGWVPAWGKNRIQAMVENRPDWCISRQRTWGVPISLFVHKETQELHPESVRLMHEVAKRVEQSGIQAWWDLDKAELLGSDADLYDKVPDTLDVWFDSGSTHSSVVDARPEFNGNPADMYLEGSDQHRGWFMSSLMIGVAMKDKAPYNQVLTHGFTVDGQGRKMSKSIGNVVSPQDVMNKLGADILRLWVASTDYTGEMTVSDEILKRSADAYRRIRNTARFLLANLNGFNPATDMVAPADMVVVDRWAVGRAKAVQAEIMAAFDEYNFHGVTQKLMQFCSIEMGSFYLDVIKDRQYTAKADSLARRSCQTALYHIAEAMVRWMAPIMSFTADEIWALLPGERGEFVFTEEWYDGLFGLEAGETLNDDFWAEILTVRGEVNKALEVARGEKRIGGSLQAELTLFAKPALAARLNALADELRFVLLTSKAKVVSVDAAPADAVATERDDLWLSVAQSAAAKCDRCWHHVEDVGTIAGHEEICGRCVTNVEGDGETRQFA | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 106106
Sequence Length: 953
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
|
A4G3E6 | MSDNQNKPGKPNKPEAKQASKYPVNMTDTSFPMRGDLAKREPQWVKQWQDKKIYEKIREASKGRPKFILHDGPPYANGDIHIGHAVNKILKDMIVKTRQFDGYDAPYVPGWDCHGMPIEIQIEKLYGKSLPTAEVLEKSRAYATEQIERQKKDFIRLGVLGEWDNPYKTMDFGNEADEIRALGTLLEKGYVYRGLKPVNWCFDCGSALAEAEVEYQDKRDPAIDVGFPFAEPEKVAKAFGLAKLPTNKGYAVIWTTTPWTIPANQALNVHPEFTYALVQTERKGETVLLILAADLVEATLQRYGLEGKTIATCVGEALAMIKFKHPFADVDPGYNRLSPIYPGTYVTADSGTGIVHSAPAYGIEDFISCKSHGLKDDEIVAPVMADGKYASWLPLFGGLTIWEASKPICAKLDEVGSLFKLVMFDHSYMHCWRHKTPIIYRATSQWFAGMDVMPKNQGTTLRETALAAIEQTEFFPGWGKARLHGMIANRPDWTLSRQRQWGVPMAFFVHKESGDLHPRTPELLEQIAQRVEKNGIEAWLKLDPKELLGDDADMYLKNKDTLDVWFDSGTTHQTVLRGSHKEQLAFPADLYLEGSDQHRGWFHSSLLTSSMLNGHAPYKALLTHGFVVDGEGKKMSKSKGNVVAPQKVSDSLGADILRLWVAATDYSGELSISDEILKRVTESYRRIRNTLRFLLSNTSDFDAGKDLVAVADMLEIDRYAIAQMNAMQNEIVAHYRAYEFHPVISKLQGYCTEDLGGFYLDILKDRLYTSGVTSHARRSAQSAIWHLTQSLLRLMAPVLSFTAEEAWVIFAGKDAGDTIFTQTYYALPEVADGDALLGKYTLLREVRNDVTKQLEEVRVAGGIGSSLQAEVALQASGDKFAALESLDDDLKFVLITSQASVKKVAGTEEESVLVTPSTYQKCERCWHYRADVGSHAEHEGLCGRCVANLFGKGEARHFA | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 107225
Sequence Length: 959
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
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Q74JX6 | MRVKDTLNLGKTKFKMRGNLPVREAEWQKEWEENKLYEQRLKLNEGKPRFDLHDGPPFANGNIHMGHSLNKISKDIIVRFKNMNGYYAPYVPGWDTHGLPVEQQLAKKGVDRKTMDRAKYRELCRQFAEEQVQKQMADFKRLGVMADWDHPYITLQPKFEAEEIRVFGEMFKKGYIYKGKKPVYWSWSSESTLAEAEVEYHDIKSPRIYVAFPIKDGKGILDSDTSLVIWTTTPWTIPSNVGITVNPKFDYSVVEVNGKKYVIGSQRLSAVAEDLGWEDYKVVKTLKGTDFDRMTYQHPLYDVTGVIMNDTYVTADDGTGLVHNATGFGEDDYNVGRRYGLPVFSPMDAQGRFTKEVPDPDLVGMFYDDANKVVADKLEKAGALLKLSFFTHSYPHDWRTKKPVIYRATTQWFASIDKFRDQILAEIEKANFIPAWGKTRLYNMIKDRGDWVISRQRAWGVPLPIFYAEDDTPIVTPETIEHVAQIFEKEGSNAWYTYTAEELLPEGFKSEHSPNGKFRKETDILDVWFDSGSSWAGVMQERDGLGFPADLYLEGSDQYRGWFNSSLITSVAVTGKAPYKQVLSQGFVLDDKGHKMSKSLGNVISPNDVIKQMGAEIIRLWVAGADTTSDVAVSQDILRQSAESYRKIRNTMRFMLANTSDFDPKEDAIAYPDMSGVDQYMEIKLNRLIEEAIEAYNKFDFNSVYKKVFSFISNDLSAFYLDFAKDILYIDAEDSETRRSMQTVIYDVLVKLTKLMTPILPHTMEEVWGYLKEPEDYVQLANMPEVDHFANEDEVLADWNAFMKVRSDVLKALEKARNAKVIGKSFEAHVTLYPTEETKALLDKLNANIRQILIVSDLTISDEEAPENAEKLPTASIVVEHAAGEVCPRCRRTTTDVGSDPRFPELCARCAAIVAENFPEAEKEGLEK | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 105960
Sequence Length: 928
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
|
Q0IDA5 | MTQQTGQDADQRPSYKDTLNLLETGFGMRANAIHREPELQAFWKEKGIDLDLGRNNPGPVFTLHDGPPYANGALHMGHALNKVLKDIINKHRLMQGRKVRFVPGWDCHGLPIELKVLQAMNQEQRQALTPIKLRKKAAAYAHKQVAGQRAGFQRWGIWADWDHPYLTLQKDYEAAQIDVFGTMALKGHIYRGLKPVHWSPSSRTALAEAELEYPDGHTSPSVYVGFPVVDLPESLRSKLNAQGLDVPAASDTLSQCLQVAIWTTTPWTLPANLAVSVNDRLDYCLADDGNGQLLIVAAELCDSIASKLERPLQAKATVKGADLAGITYSHPLLERRSAIVVGGEYITTESGTGLVHTAPGHGVDDFNTGRKHGLPVLCPVDEAGTLTAEAGPFEGLNVLKDANAKIIAALEDSGSLLLQESYSHRYPYDWRTKKPTIFRATEQWFASVEGFRTEALTAIDGVQWLPASGRNRIESMVSERGDWCISRQRTWGVPIPVFYQRETGEVLLNSDSIAHVKALIAEHGADIWWEKDEVDLLPSSHKAEAHLWRKGTDTMDVWFDSGSSWASVSSQRDGLSYPADLYLEGSDQHRGWFQSSLLTSVAVNGTAPYRTVLTHGFALDEKGRKMSKSLGNVVDPMVIIEGGKNQKQEPAYGADVLRLWVSSVDYSADVPIGAGILRQLSDVYRKVRNTSRYLLGNLHDFIPSRDAISISDLPLLDRWMLQRTATVLDQISEAFERYEFFRFFQLLQNFCVADLSNFYLDIAKDRLYVSAPNDKRRRSCQTVMALIIERLAAAIAPVLCHMAEDIWQNIPYPTGTESVFLSGWPSVPEEWRDDSLRDPMQELRELRAAVNKVLEECRSKRKLGSSLEAAVRLEARTPALQDALQWLQSKGDQEVDGLRDWLLVSQLQIGGEPWAELLASDDNELAVIEVALSRGQKCERCWHYEADIGQYSDHPGLCGRCVSVLERR | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 108080
Sequence Length: 968
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
|
Q0AYC7 | MAKGKYDGTLNLPQTGFPMRANLPQREPEILKFWDEIDIYRRIQEKNAGRPQFILHDGPPYANGNIHLGHTLNKVLKDIIVKYRSMSGYDSPYIPGWDTHGLPIEQQAIKNLGIDRHKTDVVEFREHCRDYALKYVEIQKEQFKRLGVRGDWEDPYLTLSPGFESIQIKVFGEMAKKGFIYKGLKPVYWCGDCETALAEAEVEYNEKVSPSIYVKFPVKDGKGVLPEDAFVIIWTTTPWTLPANTGICLHPGFDYVLLEVKGEKYLLAQGLLEAVAGELGWDNYQILDKYKGEELERVICHHPFFARDSLLVLGEHVTLEAGTGCVHTAPGHGEDDFHVGQEYGLEVISPVDDRGRFTAEAEKFQGLYVHDANKAVIEELEKRNMLLKAASIEHQYPYCWRCKQPIIYRATEQWFASIDGFRQDALNAIDTVKWIPSWGRDRIFNMIRDRGDWCISRQRTWGVPIPIFYCESCGEALINDETIQRVSELFAANGSDIWFAKTAAELMPPGCSCEHCGGSTFRKESDIMDVWFDSGSSHMAVLEPRQELRWPSDMYLEGSDQHRGWFNSSLSTAVAIRGAAPYREVLTHGFVVDEQGRKMSKSLGNVVDPLRMTREMGADILRLWVSSADYRNDVSVSPNIIKQSAEAYRKIRNTCRFILGNLFDFDPGKERVSYDKLSELDQWALLKLDKLIRRVTKAYEDYEFHVVFHSMHNFCTVDLSNIYFDILKDKLYCSHPQDAERKAAQTVLYDIINALVVMLTPILAFSSEEIWSYLKKEGQAESVQLLEWPQANDEYLNQAIENRMSRVLELREVVTKALEEARSKKVIGHSLGAWITIYASPEWTELLKATAGLEKIFIVSRAELKPETEAPAEALALEGVEGIRVMVQAAEGSKCERCWIIENSVGEDLKHPTLCQRCAEVVAQLQG | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 105649
Sequence Length: 927
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
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P46213 | MEYKNTLNLPKTSFPMKANLVNKEKVFLEEWEKMDLYNYVLEQRKGKPLFVLHDGPPYANGHIHIGTALNKILKDIVVKYKTMRGYRAPYVPGWDTHGLPIEHRVSQELGEKIKEMSPAEIRKKCEEFALRFVDIQREEFKRLGVRGDWENPYITLKPDYEVKILDVFKTLVEQGNVYRSLKPIYWCPRCRTALAEAEIEYHDHKSPSIYVKFRSKEDPNFFIVIWTTTPWTLPANVGIALHPDYEYSVVKVGEEKWVIATDLLDAFSKETGIDCSNVVEKIKGKDLEGKEFVHPIFDDRTSRVILADYVSLETGTGCVHIAPGHGEEDYIYGHVQYGLPIVSPVDEEGRFTEEAGKYKGMFIEDANEVIIEDLKRKGILVHASSITHSYPHCWRCKGPVIFRATEQWFISVDHNNLRQKVLEEIDKVKWIPEWGRNRIRSMVEERPDWCISRQRVWGTPIPAVKCKECGEVVLDPKVIEHFMKIVEKEGTNAWFEKEVEELIPEDFVCPKCGKRSFEKMLDTLDVWIDSGASFEYITTKREDHPFPLDMYLEGSDQHRGWFHSSIFLAVAKRGSAPYKEVLTHGFIKDEQGRKMSKSLGNVVDPMEVVEKYGAEILRLWLASSDYFNDIKISMRIVEQQTEVYRKIRNTFRFLLGNLEDFDPELDRVPHEKLLTIDRWALGRLQEIIKRATEYYDSYEFSKVYNLVVKYCTTELSSLYLDVVKDRLYVEAKDSIYRRSAQTVMHEILISLMKILAPIMTFTMEEVYSHLHEKDRKYKTVQAEYWPEYREEFIDRKLMEDFEKLLSIREDVLKALEEKRQQDVIGHSLDAEVVLVPKNDTIKALLEKYRDILEELFIVSKVSLSDASGELKGELVEVTVKHAEGEKCQRCWKYTTEISASEDFPGVCPRCLAVLKGERK | Cofactor: Binds 1 zinc ion per subunit.
Function: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
Catalytic Activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Sequence Mass (Da): 107156
Sequence Length: 919
Domain: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
Subcellular Location: Cytoplasm
EC: 6.1.1.5
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Q3Z8X9 | MPEEYLNAQKMEKLERIKSRGINPYPATFHPSHTSVQAVALLAELEKQENPPKEILRIAGRIMTLRDMGKISFMDIRDGSGKIQVFCRQNDLDEASIELLKDLDLGDFIGAEGSLMRTRTGEPSLAATKISLLSKSLLPLPEKWHGLQDVEKRYRQRYLDLISNADARQTFLTRSQVISAIRSFMSSKGFLEVETPVLQPEAGGALARPFITHHQALDCDFYMRIALELHLKRLIVGGFDRVYEIGRIFRNEGVSTRHNPEFTMMESYQAYADYKDVMDFLEEMVSSVVKEISGGYTVPFGDTTLDFTPPWPRLSMRDAVKQYAGIDFFDFPTKEALAAEMIRRKLKVDPAKDWGKLVDELVGEFVEPRLIQPTFLTDHPVAMSPLAKQKPEDPRLTERFEAICANMEIANAFSELNDPVEQRARFKEQLEKRNQLRTEESESIDEDFLAALAYGMPPTGGLGVGIDRLVMLLTNHDSIREVILFPALKDREDKGEQE | Cofactor: Binds 3 Mg(2+) ions per subunit.
Catalytic Activity: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Sequence Mass (Da): 56609
Sequence Length: 498
Subcellular Location: Cytoplasm
EC: 6.1.1.6
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Q9RXE1 | MPDAPRPPRPEGLHEQTIARLNNLDAQVDAGFEAYPYSYPQTHHARDVFAAHPAREEGTGEGGTLEPGQKWEEESYSLAGRVTLMRHMGKAAFADLSDEDGKIQLFFSKQDTAGFDATKKIDLGDIIGVKGHPFVTKTGQLTLHVTEWQPLVKSLHPLPSKFHGLQDEELRARRRYVDLMVTEGAREKFQARSRMIRYIRNELDERGFMEVEGPTLQVTAGGAEARPFMTHHNALSYDFKLRISLELYLKRLLVGGFERVYEIGRVYRNEGIDRTHNPEFTMLELYWAYADYSDIAKLVEDLLSGLAKEVHGSYQFEYQGKTLDFTPPFARVDYLGGLREHVPGLDFDPLDLDRLRAFCDERFPQWKGVPSYKLLDKLFGEFVEPLLSNPTFVMDHPAVISPLAKKHRSRPEAVTERFEVFCSGFELANAFSELNDAFDQRERFEAQTARQAAGDDEAHPQDEDFLLALEYGMPPAGGLGIGIDRLAMLLTDSDSIRDVLLFPLLRPEGGEAEEADDTAQENTAG | Cofactor: Binds 3 Mg(2+) ions per subunit.
Catalytic Activity: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Sequence Mass (Da): 59302
Sequence Length: 525
Subcellular Location: Cytoplasm
EC: 6.1.1.6
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Q0ABN3 | MDASYQPEQIEAQAQRYWDEQQSFAAREEREGEKFYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRMQGRNVLQPMGWDAFGLPAENAAMKHGVPPARWTRENIETMRGQLQRLGFAYDWDREFATCDPEYYRWEQWLFTRLYKKGLVYKKTATVNWDPVDQTVLANEQVVDGRGWRSGAVVERRDIPQWFLRITDYADELLEALDELPGWPEQVRAMQRNWIGRSEGVELDFAVAGHSDTLRVYTTRPDTLYGVTYVGLAPEHPLAAEAAEGNPEMQRFIEDCRKGGVAEADIATMEKRGMDTGLKAVHPLTGEQVPIWVANFVLMEYGHGAVMAVPAHDQRDWEFASKYGLDIRPVVHPSAEERADVSEGAFTDDGVLADSGEFSGLPSAEARQAIGEKLEGLGKGERTVNYRLRDWGISRQRYWGAPIPMIQCPACGDVPVPDEDLPVVLPEDVDVTGGGSPLKDLPAFYQTTCPQCGGEARRETDTFDTFMESSWYYARFACADQKGAMLDERADQWLPVDQYIGGIEHAILHLLYARFFHKLMRDEGLLQSDEPFRNLLTQGMVIAETYYRERGDGGKDWYNPAEVTVQRDERGRPVSAVLEDDGEPVVMGAIEKMSKSKNNGVDPQALIDRYGADTVRLYTMFAAPPDQSLEWSDSAVEGAYRFLRRYYGLVRDHVAAGPVPALDVASLDDAARDLRRKVHETIAKASDDVGRRYTFNTAIAAVMELCNALGKAAANEPSGAARAVLQEGLEAATLILAPIAPHVTHVCWQALGHDEAVIDARWPAVDESALTRDTIELVVQVNGKLRSRLQLPADADKAAAEAAALADEKVQRFTEGKTVRKVIVVPGKLVNIVAN | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 96603
Sequence Length: 864
Subcellular Location: Cytoplasm
EC: 6.1.1.4
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A8MJY6 | MKQYNPKEIESKWQNIWEERGVFHASNDKDKEKFYALIEFPYPSGQGLHVGHPRPYTALDVVSRKRRLEGYNVLYPMGWDAFGLPTENYAIKNKIHPKVVTEQNVARFKKQLQGLGMSFDWSREINTTDPEYYKWTQWIFLKLFEKGLAYKKEMSINWCTSCKVGLANEEVVNGGCERCGAEVVRKQKNQWMLKITEYAERLINDLDLVDYIERVKIQQKNWIGKSEGMEVDFEITGGKKITVYTTRPDTLFGSTYMVISPEHPYIEELAAHIQNMDDLVHYREEAAKKSEFERTELVKDKTGVKIEGIEATNPATGKQIPIFISDYVMMSYGTGAIMAVPGHDTRDWEFAKKFNLPIVEVVSGGNVDEAAYTDTEEGIIVNSDFINGMQVKEAKEKISSWLEEKGLGKRKVNYKLRDWVFSRQRYWGEPIPLVHCDCCGWVPVPESQLPVLLPEVESYEPTDNGESPLANLRDWVETTCPKCGGKAERETDTMPQWAGSSWYFLRYTDPHNNEELASKENLDYWMPIDWYNGGMEHTTLHLLYSRFWHKFLYDCGVVPSCEPYQKRTSHGMILGENNEKMSKSRGNVINPDDIVTEFGADTLRLYEMFIGDFEKSVPWSQNGVKGCRRFLDRIWKLQEILVDSQEMTKELEGNIHKTIKKVTEDYETLKFNTAVASMMALINDFYDHGTVTKGDMKTLLTLLNPVAPHITEELWEVLGFEGHIYGTTWPIWDEAKTIDSVVEIPIQINGKVKGQMVISVDFTADQVKEQFRNDERLMALVEGKSIVKEIYVPGKIYNIVVK | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 92499
Sequence Length: 802
Subcellular Location: Cytoplasm
EC: 6.1.1.4
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B3ETW5 | MSHYDFKAIEQKWQQYWKNNQIFRTTIEPSKPKYYILDMFPYPSGEGLHVGHPLGYIASDIVARYKRSKGYQVLHPMGFDAFGLPAEQFAIQTGQHPAITTAKNIGRYKQQLCQLGLSYDWDRCISTCEPAYYKWTQWIFIQLFNSWYDISLQKARPIDELITLFDQQGNQQVQASCDKEVSLFTAKEWQAMDEESKQQHLLAYRLAFLEDTTVNWCPELGTVLANEEVKDGLSERGGYPVIRKQMKQWSLRITAYTDRLLAGLEHLKWPLSTKEMQRNWIGRSIGAELNFTVIANGQEHTIPVFTTRPDTLFGVTYLALSPEHPLAKLISTGTQQAAIDTYITQATNRSERDRLADVNHVTGMFTGAYAIHPFTKQPLPIWIADYVLAGYGTGAVMGVPAHDSRDYAFAQHFQLPIIQVVAGGDTAQSAYEAREGSLFNSQFLNGLSIQEATKQAIQKLESLGIGKQKTTYRLRNAIFSRQRYWGEPIPIYYKNNIPYPIPAEELPLELPSLASFKPTPTGEPPLGHAPNWKTKEGYPIELSTMPGWAGSSWYFFRYMDPNNEASFVGSTAQNYWQAVDLYLGGAEHATGHLLYARFWTQFLYDLGYVNIEEPFQELIHQGMIQGKSSFVYRIKGTNQFVSYNLRHAYETTAMHVDIHLVKNNILDLERFKNWRPDLQTATFVLENGQYICGSEVEKMSKSKYNTVNPDTVVEQYGADTLRLYTMFLGPIEQAKPWDMHGIEGVFRFLVKVWRLFYLEKGAIITNEVPTKEVQKAIHKAIKKVEEDIKRYAFNTAVSNLMICVNELTALKCNNRAALTNLVLILAPFAPHLAEELWEILGHQHSIAQAPFPTYEEIYLQEETYEYPIAINGKVRAKINFPVDMPQGQIEEQVLTHESIQKWIQGQQIKRVIVISSKMVNIVI | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 105607
Sequence Length: 923
Subcellular Location: Cytoplasm
EC: 6.1.1.4
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A8IMK0 | MSTDRYNARDAEPRWQAIWNERGIFRTRNDDPRPKFFVMEMFPYPSGRIHIGHGRNYVMGDVLARYKRMQGFNVLHPMGWDSFGLPAENAAIERGIHPKSWTYENIASMKEQLQLLGLSLDWNREVATCDPSYYAEQQRLFLDLFENDLAYRKESEVNWDPVDNTVLANEQVIDGRGWRSGAVVERRKLNQWFFRITAFAQELLDAIDTLDRWPDKVRLMQRNWIGRSEGLEVLFELSKGSVAAAGTSAVKVYTTRPDTLFGASFLALSPDHPLTQHLAATRPDLAAFVADCKTGGTSAEAIETQEKKGFDTGLTVVHPLDAARTVPVYVANFVLMDYGTGAIFGCPAHDQRDLDFARKYGLTVTPVVLPPGADPAVFAVGSEAYDGEGTLYNSQFLDGLSIADAKEQVARRLERFRVGEQPQGTRKVNFRLRDWGISRQRYWGCPIPIIHCDSCGPVAVPREQLPVELPDDVTFDRPGNPLDRAKAWRDVPCPKCGAPARRETDTMDTFVDSSWYFLRYASDNPDKPLDKDAVRHWLPVDQYIGGIEHAILHLLYSRFFTRALKACGRVDVAEPFAGLFTQGMIVHETYKDKDGRWLFPEEVKLLGDGKAEKLDDGSPVTVGPPEKMSKSKKNVVPPEVVVDTYGVDAGRWFMLSDTPPERDSEWTQSGIEGAWRFVQRVWRQVQEAIELGAPKGADKPASFDAAATALRRAAHGLAHQVADDVERLRFNVAVAHVHEFANAFGQAIASARTASPVPADLAFALREAAEIVTRVVGPMVPHLAEECWAALGYDTLLAEAAWPKAEPELLVENTITLPIQINGKKRDDITVPRDATAAEVEAAVLEMESVRRALDGKAPKRIIVVPQRIVNVVA | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 97619
Sequence Length: 874
Subcellular Location: Cytoplasm
EC: 6.1.1.4
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B6YRS4 | MKYDFDAIEKKWQKYWKENRTYQVNIDRNKPKYYVLDMFPYPSGVGLHVGHPLGYIASDIYARYKRLKGFNVLHPMGYDAYGLPAEQYAIQTGQHPSITTKENINRYRKQLDKIGFCFDWDREIRTCDPKYYQWTQWVFIQMFNSYYCKEAQRARPITELVKILENQGTGGLHLACTKEIHLTANEWQMKDEKSKQAILMNYRIAYLSDIVVNWCPALGTVLANDEISGGISIRGGYTVEQRKMRQWCLRISAYAKRLLEGLDKIEWTDSLKKMQRNWIGRSEGVELRFKIKDENIEFMIFTTRPETIFGVTFIVIAPESEWLTQTIISKKKDSVDSYLNLVKRRTERERISNRKVTGVFTGSYAVHPISGETIPIWISDYILADYGTGAVMAVPAHDSRDYAFAKHFDLPIIPLIEDIDISKESFDIKEGIMTNSDFLNGLSVKQAIQKVKEYIKDENLGKIKVNYRLRDAIFSRQRYWGEPFPIYYKNGIPYAVDEEDLPIKLPEIDKFLPAETGKPPLGRAKNWTYKGYPLELTTMPGFAGSSAYYLRYEDPHNSECLVSSEANEYWQNVDLYIGGIEHATGHLIYSRFWNKFLFDLGIVAKEEPFKKLINQGMIQGRSNFVYRIKNTNTFVSYGLKHQYDVTPIHVDINLVFDDVLNIESFRDWNSEYKNAEFILENGKYVCGWAIEKMSKSMFNTVSPDNIVNRFGADAFRLYEMFLGPLEQSKPWDTKGIDGIARFLKRLWNLFFENDVLKVSNSLPLDKELKSIHKLIKKVSWDIENFSFNTSVAAFMICINELTLLKCSKHSILSDLVIVLAPFAPHIAEELWHLLGNEATIFDSQFPKCNEEYLKEENVKYTVSFNGKARFILNFPKKISEENVKDTVLKCESSKKWLKNKIPKKIIIIPNKIVNIVFD | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 106760
Sequence Length: 918
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
A9BF22 | MEKTYNPQEIERKWQRNWQEKDAFKVSNEEYHKKYYDLVMFPYPSGTLHVGHVKNYVIGDVIARYKRMRGYNVMHPFGFDAFGLPAENAAIEKGNIHPEDWTMQNINIIRNQIKKLGISYNWEREVITCKEDYYKWTQWIFLQLYKNGLAYKKKAPVNWCPNCKTVLANEQVVNGKCERCGTVVEIKQLEQWYFKITDYAEKLLYDLEKLSGWPENVKIMQKNWIGKSVGAEVEFNLDNGKGSLRVFTTRPDTLWGVTFMALAPESPLVEELTTPENSEKVNQFLQRVSLQDRFKRTAEGAEKEGVFTGSYAINPVNGEKIPIYVANYILYEYGTGAIMAVPAHDQRDFEFAKKYDLPIRIVIMPEGDELTEENLEKAYIGEGVLVNSGEFTGLDNQTAIREVSQWLEDKKIGKVVTQYKLRDWLISRQRYWGAPIPVVYCEKCGVVPVPEKDLPVKLPRDVAFEPTGKSPLIDHPDFKETTCPKCGGKAKREVDTMDTFVDSSWYYLRYVNPKLEDKPFNKEDVDNWLPVDQYIGGVEHAILHLLYSRFITKVLKDLGYVSFDEPFKNLFTQGMIYRNGAKMSKSKGNVVSPEEMIEKYGTDALRTYILFMAPPERDAEWNDSGIEGTYRFLNKVWNTYMKIQDKIIHLENKPNYPLKNKSEKDLRRKLHQTIEKITSDIEGNFQFNTAVSSLMELLNELNSYLNNTDDKDWNLNLLKEFSEDFVLMLSPIAPHISEELWKNFGKDEFIFKASWPEIDKNALKAEEITLAVQINGKLRAQITVDVSLNEDEVKSYALEDDKVQKYISGKKIQKIIYVPKKIINIVVK | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 96100
Sequence Length: 828
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
B2RIZ3 | MEYNFQEIEKRVQGQWRKDKVYRVAEDTSKKPFYVLDMFPYPSGAGLHVGHPLGYIASDIFSRYKRLRGFNVLHPMGYDAFGLPAEQYAIQTGQHPEKTTEENTARYREQLDKIGFSYDWEREIRTCDPNYYKWTQWAFLKMFDSYYCNQAQQARPISELIEVFARQGNEGLNVACGEGVRFTAEEWTAMSEKEQQEILMNYRLAYLGDTMVNWCPALGTVLANDEVKDGVSERGGHPVEQKKMRQWCLRVSAYAERLLHDLETLDWTESLKETQRNWIGRSEGAEMEFRLAGKDCTFTIFTTRADTIFGVTFMVLAPESELVEEVTTEEQRAAVETYLTETKRRTERERISDKRVSGVFSGSYAINPLTGKEIPIWISDYVLAGYGTGAIMAVPAHDTRDFAFARHFDLPIVQVVVPEGETATDPATWEDAKDSKSGIMVNSDFLNGLSVEDAIAQTKEYIREKHLGCVKVNYRLRDAIFSRQRYWGEPFPIYYKEGMPHALDEDRLPLRLPEVDKFLPTESGEPPLGRATGWHTAEGYPYELSTMPGFAGSSAYYLRYMDPQNDTALVSRSANEYWRHVDLYIGGTEHATGHLIYSRFWNKFLFDLGIVCEAEPFRKLVNQGMIQGRSNFVYRIKNTNTFVSYGLREQYEVTPLHVDVNIVSNDQLDIDRFRAWRPEYASAEFILEDGKYICGWAIEKMSKSMFNVVNPDDIIARYGADTLRLYEMFLGPLEQSKPWDTNGIDGVHRFLKKFWALYYNADGIRVTDTAPTKEELKSLHKLIKKVGQDIESFSFNTSIPAFMICVNELTAAKTTSRAILCPLLTVLSPFAPHITEWLWQELGVEGSIVTATWPEYNEEYLVESCVRYPVSFNGKVRFNIELPADMSKKDVEQAALTAPEAARWLEGKSPKKVIVVPGRIVNVVV | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 106051
Sequence Length: 925
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
Q67SB4 | MAEERFDFREAEPRWQRRWDEEGIYKVERDLSRPKYYALAMFPYPSGKLHMGHVRNYTIVDVIARYRRMKGYNVLHPMGFDSFGMPAENAAIQHGANPAVWTRENIAEMTAQLKQMGYSYDWSRAVYTYREDYYRWTQWLFLQFYKKGLAYKKTAPVNWCPSCQTVLANEQVEDGRCWRCDSVVTKKDLAQWFFRITQYADELLEDLKLLEGGWPEQVRIMQQNWIGRSEGARVEFTLEATGDKIPIFTTRPDTIYGVTFMVVAPEHPIVEKICTSGLIPEERVAAIRAFQEKMKHLSEIARTSTEAEKEGLYTGLDVINPFNGEKAQLWIANYVLMDYGTGAVMGVPAHDQRDFEFAQKYGLPVKVVIQNPEGTLRAEEMTAAYVEPGIMVNSGPFDGTPNLEGIPKVIAYAEEQGFGQKTVSYRLRDWLISRQRAWGAPIPIVYCDKCGTVPVPEKDLPVRLPDDLDFTGEGGSPLARHEGFVNTTCPQCGGPARRETDTMDTFVCSSWYFLRYTDPQNAERPWNREDVDYWMPVDQYVGGIEHAVLHLLYARFFTKVLRDMGLVKVDEPFARLLTQGMVLKDGSKMSKSKGNTVSPEEMIAKYGADAVRLFIMFAAPPERDLDWSDAGIEGAARFVNRFYRMVVSALPAYQHARSLLPINPADPASVMGALSEAEIAEGLAKAAPNLTAEDRELRRVIHATVKRITADLHDRFAFNTAISGLMEMTNAIYAYREKQHAEQNTSALVLAEAVQKAVLIIAPFCPHLADELWSRMGHPRSIHLEPWPAYDEEVAKADTVEIVVQINGRVRDRLEVPAGISAAEMEAVAMASEKVQALVAGKQIVKVVPVPGKLVNIVVKG | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 97335
Sequence Length: 861
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
Q31LW9 | MQNGANSRSQEYQGVSVDSRYDPQAIETKWQQSWAAAQLDRTPEADDRPKFYALSMFPYPSGNLHMGHVRNYTITDAIARVKRRQGFRVLHPMGWDAFGLPAENAAIDRGVQPADWTYQNVAQMREQLKQLGLSYDWDREVTTCSPDYYRWTQWLFLQFFEAGLAYQKEATVNWDPIDQTVLANEQVDSEGRSWRSGAKVERRQLKQWFLKITDYAEELLQDLDQLTGWPERVRLMQANWIGKSTGAYLEFPIVNSSDRVKVFTTRPDTVYGVSYVVLAPEHPLVTQVTTPEQQTAVAAFAAEVSQTSELERTAEDRPKRGVPTGGFVTNPFTGQAVPIWIADYVLVEYGTGAVMGVPAHDSRDFAFAQRYGLPVQPVIQPTEGAIAEPWPAPFTEAGVMVNSGQFDGLSSTEAKAKIIAFAEEQGWGQAHVQYRLRDWLISRQRYWGCPIPIVHCPDCGPVAAADLPVQLPDSVQFSGRGPSPLAQLEDWVTTTCPSCGKPARRETDTMDTFMCSSWYYLRYSDASNPEIAFTKDKVNDWLPVDQYVGGIEHAILHLLYSRFFTKVLRDRGLLSFDEPFKRLLTQGMVQGLTYKNPKTGKYVPSDRISDPSQPVDPDTGDRLEVFFEKMSKSKYNGVDPARVLDRYGADTARMFILFKAPPEKDLEWDDADVEGQFRFLNRVWRLVQTASQVEATTAADDKAEKDLRRAVHTAIQAVTEDLEEDYQLNTAIAELMKLTNALNDAPMPGSPAYLEGVQTLVLLLAPFAPHIAEELWQQLGGERSVHLEGWPVLDESALIVDEIPLVIQIMGKTRGTITVPASADRDQLQQLAENSEIAQRWLDGQTIRKVIVVPGKLVNFVIASP | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 97336
Sequence Length: 865
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
Q2JV13 | MDARYNPPAIESKWQAHWRELGLDRTPELTAESRKFYALSMFPYPSGSLHMGHVRNYTITDVIARHKRMQGYAVLHPMGWDAFGLPAENAAIDRGIPPAKWTYQNIAQMRDQLQRLGLSYDWEREITTCAPDYYKWTQWLFLQFFKAGLAYQKEAPVNWDPVDQTVLANEQVDAEGRSWRSGALVEKRLLKQWFLKITAYADQLLADLEKLSGWPERVLTMQENWIGQSVGARVVFKTETGEELPVFTTRPDTLWGATFMVLAPEHPLVEKLTTPEQEVAVKAYRAEAAARSEIERSAEDREKTGVWTGSYAINPVNQERIPIWIADYVLMGYGTGAIMAVPAHDQRDFEFARQFGLPIKLVVQPPQGGVTSAEDLQAAWTGEGVLINSGPLNGIPVGKGPGQSVERAIAWLEEQGLGERQVNYRLRDWLISRQRYWGCPIPIIHCPHCGIVPVPEEDLPVLLPEDVELTGRGGSPLAQLEDWVKVKCPACGADARRETDTMDTFICSSWYFLRFSDPRNDREIFRKDLVNAWLPVDQYVGGIEHAILHLLYSRFFTKVLRDLGLLNFDEPFSRLLTQGMVQARTYYNPNKSGKDRWIPTALVKDPNDPRDPETGEPLQVIYATMSKSKGNGVDPEEVLANYGADTARMFILFKAPPEKDLEWDDADVEGQFRFLNRVWRQVYEFVVRGSGTESLQGKAAELLQAKVEAGSLTKAERDLRRAVHTAIKEVSEDLEEYQFNTAIAGLMKLSNALAEAEIPDSPVYAEGIRTLVLLLAPFAPHMAEELWQALGGTDSVHRQAWPTYDPAALVADTVTIVVQVNGKLRGSFEAPADVTPQEQERLALQSEAAQRYLQGMTPKRVIVVPKKLVNLVV | Catalytic Activity: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Sequence Mass (Da): 98433
Sequence Length: 873
Subcellular Location: Cytoplasm
EC: 6.1.1.4
|
Q8YH17 | MSREKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRELADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQVIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRGEKMSKSVGNVIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAAPADKRQFADVLASPLAGGTDLPAPQPVFPRYVEADEQN | Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 57998
Sequence Length: 515
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q89AX4 | MKKRILVTCAFPYANGSLHIGHFLEHIQADIWVRYKKMRGHEVWFICADDAHGTPIMLKSQSLKMSPESFISDIYKDHVNDLEKFNINYDNYYSTHSSENSYFLKKIYHILDKKGLIQTRNIFQLFDNTKRVFLPDRFVKGACPICHTKDQYGDHCEVCGSSYSAVELIKPVSMLSGNCPILKKSLHFFFNLPYFESMLRSWVMSGVLQASVVKKLDEWFKLGLREWDISRDSPYFGFNIPGFLDKYFYVWLDAPIGYISTFKNLCTQRNNLNFLDFWKKNSECELYQFIGKDIVYFHSLFWPSILEASNFRKPTKIFVHGHVTINGLKLSKSRGDCILAKNWIKNLDSDSLRYYYASKLSSKIQDIEVNAKHFLYKINSDVVNKIVNLASRVSSFINIYFNNELSSRIDDLALYKRFVTSSSYIEKMLENCEFNSAISMVISLADIANSYVDNKKPWNLTKNIKNSNTLHDICTTVLNLFRILMTWLKPVMPDLAKNSEKFLNIKLEWANICIPLLNHKISIFKALRHRIEDKQIKFLLPNNFE | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 63701
Sequence Length: 545
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
P47267 | MKRCYITTPIYYASGKPHIGHAFTTILADVIKRFKIQNGYEAFLLVGSDEHGNKIESKAKSLNLDPKTFVDINAQAFKLMWKTLNISFDHFIRTTDEIHKQQVQKTFQDLYDKKLIYQSEWKGAYCVECEQNYFTFNKQTMLCEIGHNLSLVQEPCWFISFSSTKNWIETTIGKNQLNIIPKSRASELKNNFINNGLNDLALTRKNVTWGIKVPFDPNQTIYVWFDALFSYITNLGFRNGDPNFIKWWNNDNKEREVIHLISREITRFHCIYWPIFLHLLDIKLPTQFLSHGWIVDGEGRKMSKSLNNVISPEQLIDQFGVDGTRYCLLKEMRLDKDNRCSVSILKEIYNADLANSFGNHVSRTFGMIKKYLNGKLEYQIITDNALQKIMILIDESIVQFDHYFNSYEFYRAINLLLKIVFELSKLIDDFKPWELFKNQEFSLLKQLLFTCVRCVQVCYVLLTPILVNTASKVFHLFNFADDACRKDQLRDATLLKKIIISNSMEVLFKRVD | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 60007
Sequence Length: 512
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q9CD55 | MRPYYITTAIAYPNAAPHIGHAYEYIATDAIARFKRLDGLDVRFLTGTDEHGLKVAQAAEAAGVPTAQLARRNSGVFQRMQEALHISFDRFIRTTDADHYKAAKEIWRRMDAAGDIYLGTYSGWYSVRDERFFVDSETKLLDNGIRVAVETGTLVTWTEKEQTYFFRLSAYVDKLLAHYDANPDFIGPEVRRNEVISFVSGGLEDFSISRTSFDWGVQVPEHPDHVMYVWIDALTNYLTGAGFPDTDSELFGRYWPANLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNHGEKMSKSVGNIVDPMALVQTFGVDQVRYFLLREIPFGQDGNYSEEAIITRMNTDLANEFGNLAQRSLSMVAKNLGGVVPEPSEFTSADTALLTTADGLLERVRGNFDGQAMNLALEAIWLMLGEANKYFSSQQPWILRKSESEADQARFRTVLYTTCEVVRIAALLVQPVMPESAGKMLDLLGQEEDQRAFTAVSVRLAPGTVLPPPTGVFPRYQPSEIEGADPVKSSSKRREHNKRRE | Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 60448
Sequence Length: 537
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q50319 | MKKTIYITTPIYYPSGDLHLGHIYSTNIAWVLRNYKKIQGYETFFSTGSDEHGQKIFNKAQELKLETQDYVDRQANKFIDFWKKANIDYDFFARTTNKEHKEVVREIFHKLKEKNIIYLDKYVGLYSVSDEEFLTETQALKKDNKFFHPVSNHELIKIEEESYFFNLNLFIDWIKEFLDQDIISSKAIVNELKSNFINKGLENLSVTRIKLDWGIKIDQSSKHVIYVWLDALFQYLTNLGYGSKNQSLYEKFWKNGDERVHVVGKEITRFHCIYWPIFLKSLNVKMPTKIISHGWIVTPEGKMSKSKGNVVDPVVLIEKYGSEVLKYFLIAKLSIKKDGVFSEELLVSAYNNDLVNTFSNLISRTVKMILNNYDRPLSFILSKDQEDLEIEKDIKNSFETFCSFAEEYEFDKAFESTINLGKKLNLYIDKTRPWLLTKEDQKLEIVLNRLLNGIYAMAFELSIVMPQTSQKLAKALGFESFEKSKLEDFKKFDNIKIEKIENLFNRIKL | Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 59892
Sequence Length: 509
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
P9WFU5 | MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK | Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 58093
Sequence Length: 519
Domain: Lacks the Zn(2+) binding motif and the C-terminal dimerization appendix that are found in MetRSs from several organisms including E.coli MetRS.
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q1D8K2 | MAERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNAAKQGLKPEEFIARFHEEHQRDFHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERRNIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCGKAYDPTDLIDARCALCGTPPVRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFAIPGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFHALFWPAVLNVAGFHIPSEIKVHGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAANLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLAGPLEKRLAPGRAEGPGRELVEAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDAADVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRLEEERVNAIIKLPEGAAAPQAAEARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEYDDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTIVSGIAEAFAPEALTGRNVVVVANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 77332
Sequence Length: 703
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q74MZ1 | MRILVTAALPYSNGPIHLGHIAGAYLPADIFYRFVKLKGYNALYICGSDQYGSPIELNAIKLNIDPKDYASFYRKIQEEIFKKFNIKFDIYSGTAESNIHPIIVKEFFLSLFSAGLLIEKEQELPYDPKIKRFLPDRFVVGQCPYCGYEKAYGDQCEKCGRLLEPKELINPKSAITGEKVIFKKTRHLFFNIPKLKDKLKQYIESKKDVWNDFTYSWSLALLDNFKERAITRDNKWGVKVPAKEMLEILKKALKEGKTPKDFGLLIDSTNEKDLENHIKEYENKVLYVWFDAPIGYISFTFETSPEYRYYWDEKEKPYIVHFIGKDNIPFHTIFWPALIIGRNLGYKNINHILDFDIALPYQVFGNPYLNYYGKKFSKSKRWGVFLDNIDKIDIDIDYFRFYLAYIHTVSKDMSFEWDQFKEVINKELVDNIGNFIHRVLTFIYNRFNGIPPKIEHLDDKDKELLDKIKQLPEKVFNFIWKGEIGNALREIVNTSNLANKYFQEKEPWKTNDPNTIAIAFEAVKTFIILLYPFIPEKAKLLASIANIDIKWDFNQKVEKINKPFIVFHKLSDNQIEMAKQILTNPKEYDLGKKKVIGVLRYEDELYKIELECDDNPWVCLKRELDKRKIKYIYDTVKGDVPPHIIDGNTYIYLLPALEKPNLEKAEEEYGLVSYLDFAKLDMRVGKIIDVQDHPNADKLYIIKVSLGNKQKTLVGGLKQYYKKEELIGKYVVLINNLKPKQLRGITSEGMLLAADDGKEVALLMPDKPISLGSKVR | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 90600
Sequence Length: 776
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q3IT47 | MHEEFPTETPAVVTCGLPYANGDLHVGHLRTYVSGDAYARALESLGQSVAFVSGSDMHGTPIAVNAAEEGVDPESFAVEYHEQYEETFPQFNIEFDNYGHTHDETNTEMTRSFVRSWIDDDHVVEKEIEVAWDAEADQPLPDRFVEGTCPYCGEKARGDECDEGCQRHLEPGEIEAPVSTITGNPAEYRTRPHKFLRLSDFQEYLRGFIDRLEGTENAQNQPREWIEGELQDLCITRDMDWGIDYPADGDESGEDLVLYVWVDAPIEYVSSTKQYSEQVGRDEYDWEAVWKNQVDGVPPEGGEIVHIIGHDIIQHHTVFWPAMLRGAGFNEPRAVMACGFVNLDGDAFSTSRNRAVWADDYIESGLHPDLYRYHIITGSEFTADVDFSWDGLQERTNSELVGTLGNFLYRSLLFAERNYGGTPDAAVSDEVRNEIEAAMADFRTAVNDYRVRGLGRAPVELATFGNEYIQRHEPWKLTDDDPEKARQVIRDCVQIAKAIAVLAEPVLPGKAAALWDQLGEDGSVHDAELGAALESPPEAFDEPDELFEKLEDDRIEELNRQLEERIEAADAGDEEGEDEDEEPPAADLEPVADERISFGDFQDLDIRVAEVLEAEPIEGADDLAKLAVDIGVETRQIVAGIKQLHDLDSLSGTRIVVVANLEKAELFGVESNGMLLAAGEQADLLTTLEDAEPGTKVQ | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 77762
Sequence Length: 698
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q82WP0 | MTIRNILVTSALPYANGSIHLGHLVEYIQTDIWVRFQKMQGHTVYYVCADDTHGTPVMLRAEKEGISPEALIARVHAEHLRDFTGFHIAFDQYYSTHSDETRYYAEDIYRKLKEAGLIAVRAIEQLYDPIKNLFLPDRFVKGECPKCGAAEQYGDSCEACGAAYTPTELKNPYSAVSGATPVRKTSEHFFFKLSDSRCADFLRRWTHEGNHLQAEAANKMAEWLGEAGENKLSDWDISRDAPYFGFEIPGETGKYFYVWLDAPIGYMGSFKKLCARKGIDFDAYWKKDSTTELYHFIGKDILYFHALFWPAMLENAGYRTPTQIFAHGFLTVNGEKMSKSRGTFITAESYLEQGLNPEWLRYYYAAKLNGSMEDIDLNLDDFVARVNSDLVGKYINIASRCAGFISKRFGGKLVSGEDYRLLQQMVDEHFAGWQPGVIEAAYEARDFSAAVRHIMRRADEVNELIHELAPWEIARDETRERELHRACSLGIQMFYLLSCYLKPILPRTAAQIEDFLNLGELSWQKQQAGQPLSDTLLPPGHVINPYQHLMTRIDPKQITALITANQQTMQQTMNTETESHSPQRHGQAQQHPVAPIAETISIEDFVKIDLRIARIVDAQHVPGADKLLQLTLDIGSEQRTVFAGIKSAYDPEQLKGRLTVMVANLAPRKMKFGLSEGMVLAASGENGGGPFLLAPDSGAQPGMRVK | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 79662
Sequence Length: 706
Subcellular Location: Cytoplasm
EC: 6.1.1.10
|
Q2Y7P0 | MNKRKILVTSALPYANGSIHLGHLVEYIQTDIWVRFQKMQEHEVHYVCADDAHGTPIMLRAEQEGITPRQLIDRVWHEHKTDFDGFHIGFDHYYTTDSPENQAFCEDIYRQLRAGELIAKRSVEQFYDPVKQMFLPDRYIKGECPRCHAGDQYGDSCEACGATYLPTDLISPYSAVSGARPERRTSNHYFFKLSDVRCEAFLKNWIFESIPAQPGVALETRPRLQPEAANKMNEWLSAGLVDWDISRDAPYFGFPIPRTGGKKFFYVWLDAPVGYFGSFKNYFKQNQRTQAEIDEFLRPGGNTEMVHFIGKDILYFHALFWPAMLEFSGYRTPTQIYAHGFLTVNGQKMSKSRGTFITAESYLKQGLNPEWLRYYYAAKLNDSMEDIDLSFEDFVARVNSDLVGKYVNIASRCAGFITKKFGGELTHNVSEASRKWFNQFLFCELGEGDTFLGRHMSIANFYERREYSKAIKEIMSAADVANQYVDRMKPWVLAKDSRNDRELHEVCSVALNMFRMLTVYLKPVLPKLAMEAEQFLGLDPLTWKDANSQHRLLPDGHRINDYQHLMTRIDPKQIEMLTHANKESLAPAKSQQVAQAVETMEKNSSTTPAPAKEGEAGQASASTISIEDFGKIDLRVAKILDAEHVPGADKLLKLTLDVASEQRTVFAGIKSAYDPGQLKGRLTVMVANLAPRKMKFGISEGMVLAAGDGEGPYLLSPDEGARPGMKVK | Cofactor: Binds 1 zinc ion per subunit.
Function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic Activity: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Sequence Mass (Da): 82633
Sequence Length: 728
Subcellular Location: Cytoplasm
EC: 6.1.1.10
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O62732 | AHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEYKQLIVELVVNKMAQALPRQQQRDASPGRGSHSQTPSPGALPLGRQTSQQPSGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPVSQAQPLSQAQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGQAPPKASGAPPSGQQRQGPPQKPPGPAGPTRQASQAGPMPRTGPPTTQQPRPSGPGPAGRPAKPQLAQKPSQDVPSPATAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVK | Function: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity).
PTM: Substrate of different protein kinases. Phosphorylation promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover and neurotransmitter release.
Sequence Mass (Da): 43389
Sequence Length: 415
Subcellular Location: Synapse
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O88935 | MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATPGSATASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMTQALPRQPQRDASPGRGSHSQSSSPGALTLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQSASQATPVTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGAPQATRQASISGPAPTKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPGPRTGPPTTQQPRPSGPGPAGRPAKPQLAQKPSQDVPPPITAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD | Function: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis . The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (By similarity).
PTM: Substrate of different protein kinases. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover.
Sequence Mass (Da): 74097
Sequence Length: 706
Domain: The A region binds phospholipids with a preference for negatively charged species.
Subcellular Location: Synapse
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Q92777 | MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPERRPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPGPSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD | Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
PTM: Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).
Sequence Mass (Da): 62996
Sequence Length: 582
Domain: The A region binds phospholipids with a preference for negatively charged species.
Subcellular Location: Synapse
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Q7UHE1 | MWWRRSRTNSLRYTVHPFASLQRSMIAPMDWTTIDACRTSTELPRPVEIRGWIRTRRDSKGGFSFLEVNDGTSLGNLQVVAPAELENYAEEIQKLTAGCSVVVQGELVESPAKGQSTELHASSVRVIGWCDGETYPLQKKRHSFEKLREWSHLRARTNTLGAVMRVRNRISQSIHRFFDDEGFNYLHTPIITASDCEGAGEMFRVTTLNLEKLAGSNRPFDTKQDFFQKPTHLTVSGQLEAETYATALSRVYTFGPTFRAENSNTSRHLAEFWMVEPEAAFYDLNDNMQLAERFLKRVFSDCLSHCGEDMDFFNERIEKGKIDQLKSVIEKPFEHMTYTDAVERLLACDEKFEYPVNWGTDLQAEHERYLTSVVGGPVILTDYPSSIKPFYMRVSDDGKTVAAMDVLVPGVGEIIGGSQREERLDVLQRRMAEGGLDESEYWWYVDLRRYGTVPHAGFGLGLERAVQYVTGMANIRDVIPFPRTPGNAEF | Catalytic Activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)
Sequence Mass (Da): 55855
Sequence Length: 490
Subcellular Location: Cytoplasm
EC: 6.1.1.22
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C1F3P3 | MHRWSRLFVPTLREAPSDAEVASHKFLLRSGYIRQLGAGIYSYLLFGQRSINKIVGIVREEMDKIGQEFLLPAIHPADLWRESGRWTVMGDNMFRLKDRKGAELCLGMTHEEVMTDIARNELRSYKQLPQIWYQIQNKFRDEPRPRSGLLRVRQFLMKDSYSFDLNQAGLDKSYDLHDAAYRAIFTRCGLNFVVVEADSGAMGGSGSQEFMVYTDAGEDLIASCAKCGYAANMEKATSKLAPVEELAATGDGQPELISTPGQAAIADICKFLGMQPHSDIKCVAYMAEVPSEDGKTSTWEPVAAFLRGDHFVNETKLLAVVGATELRPMQAEELEKWMHGPAGYLGPVGLTPAKKLRDGSLNVVLDLGLEGRRNLVAGANKLDYHYRNVTPGRDFTWTVAADIRNAAEGEGCPVCGEPLKVAKAVEIGHIFKLGTKYTESMGARVLDENGKEVMPVMGCYGIGIERILTASIEQNNDANGFWLPRSIAPFDVVVTITNMADETLRQAGEALAAQLEAAGYDVLLDDREERAGVKFKDADLVGIPYRFNVGKKTLEGKTELVTRATASSQDVALDAAVEALKALTA | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 64330
Sequence Length: 585
Domain: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
|
A0RUI8 | MKVGITASKSDDFSEWYTQVVLKAELADYAPVKGLIVLRPDGYSIWESIRTSLDVKLAARGVRNGFLPVLIPESLLGKEKEHFAGFNPEVFWVTHSGENKVGDRLALRPTSETLAYSLYSKWIKSWRDLPLRINFWNTALRAEIKSTKPFLRTSEFLWQEGHTVHACSEEAESEVAAILELYRETVEGDLAIPVITGRKSEKEKFVGAVYTTTMESMMPDGRALQMGTSHFLGQNFSRPFEVKFADKDNVEHFAWQTSWGLSWRLIGAMIMVHGDDKGLVLPPKVAPLQVVIIPISYSGEEGAQVLAAAEGMEAELLKAGIRARTDKREELTPGFKFHDWEMRGVPVRIEIGPRDLKDGSAVLATRHDGKKSKVPLDGAAVNIEEELCRVQTEMLGAAKRALDGMIHDASSYGALTKAVEGGGFVRAAWCGGLECEEKVKEETGADIRVVPEGGAEGACIVCGGRAASIPLFARGY | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 52400
Sequence Length: 476
Domain: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
|
Q5ZXN7 | MRASQWFLVTQKETPNDAEIASHQLMLRSGMIRKLGSGLYTWMPLGLRVLRKVENIVREEMNKTHAMELLMPSVQPAELWQETGRWETFGGQLLTMKDSNQREYCFGPTHEEVITDIMRNELQSYKQLPVNFYQIQTKFRDEIRPRFGVMRAREFIMKDAYSFHLSLESLQETYKDMYQAYCRIFDRMGLKYRAVEADTGAIGGSASHEFQVLAESGEDLIFYSDASDYAANIEQATSLKPLKANQPCNETITLVDTPNQKTIDEVASFLGIASNQTIKTLIVKGKEHPMVALVLRGDDELNEVKAIKHPLVHAPLSFIDEELILKTLKTPLGSIGPIQLNIPVIVDHHALAMPSFVCGANQADKHFINAAWERDAKYDDAYDLRNVKEGDPSPDGKGTLHCCRGIEVGHVFQLGDKYAKAMNASVINEQGQLQTMIMGCYGLGITRVVAAAIEQHHDEHGIIWPQALAPFQVNIIPLNGARSQAVKEQAESLYQQLKSHGIDVLLDDRNERAGVLFADNDLIGIPHRLVVSERNLEQGCVEYKARISSETQLINLDKVVNFIIELINK | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 64122
Sequence Length: 569
Domain: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
|
Q7UGJ7 | MRGDRMSKAPRTAISPTREENYPEWYQQVIRAADLAENSPVRGCMVIKPWGYQLWENVQRALDDMFKATGHQNAYFPLFIPMSFLEKEAEHVEGFAKECAVVTHHRLEPDPDGGLRPAGKLEEPLIVRPTSETIIGATYAKWVQSYRDLPILINQWANVVRWEMRTRMFLRTAEFLWQEGHTVHATSEEAVEETEKMVEVYRDFAENWMAMPVIVGSKTPLERFPGAVETLSIEAMMQDRKALQAGTSHFLGQNFSKAQEIKFQSESGDIEFAWTTSWGVSTRLIGALIMTHSDDDGLVLPPRLAPTHVVIQPIYKDDSRAEVMEYVQSLRDELAAQTYANAPVRVTIDDRDIRGGEKKWYHVKRGVPIRLEVGPKDIAAGTVFCGIRNQPKSVGIDRAELVATIGEKLATLQQELFDAALKMREDNTVELTSEAEFRDFFADKGDTAITGGFAWCHYCDEDSLQPLLKELKVTIRCVPRSDNATEGTCFLTGKPAAQRAIFAKAY | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 57181
Sequence Length: 506
Domain: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
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Q979Q5 | MENKKENFSEWYNEIVTISDLSDKRYPIKGMNVWRPYGWKIMKLIDNIIRNAVDKHSFDEVNFPVLISRGMLEVEFEHIRGFENEIYWVTKGGKEKLEEELALRPTSESAMYPMFSLWVRSHADLPLKIYQIVSVYRYETKHTRSFIRIREIHFFEAHTAHESYEDAEKQMDEYRIIWTEIADALCLPFLYDQRPEWDKFPGAMYTIAFDTVMPSGRSLQIGTIHQYGTNFSKNYDIKYLKEDGTFEYVHQTTFGMSERLLAAIIGIHGDDKGLILPPAIAPIQVVIVPIPGEGVERYAKDIETTLNGIGIRCHVDNRDNYTPGYKYNDWEMRGVPLRIEVGERELKEKTVTLAARNIRGKKTVQREKLVYEVPDMLDLVKEKITEDAKKTFNSLVVSASSLDDFKKEGLIKAFWCGSKECSDKIENETEKSALGFNLNNDETGKCIVCGKAGKLAIFSRSY | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 53465
Sequence Length: 462
Domain: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
|
B5YKW0 | MRYSKLFIPTMREIPSGINAISHILMLKAGYVRQLAAGLFIFLPLGWRVLNKINMILKEEMERIGAQEISMPILHPAEIWQETGRWYTIKEEMFRLKDRTGRDMCLGMTHEEIMTWIASKEIKSYRQLPQIWYQIQTKLRDEARPRGGVLRTREFIMKDSYSFDIDWEGLDKSYNLHAEAYHRIFTKCGLKYYQVESDPGIMGDMESHEFMAPTPAGEDEIVLCDSCGYSANIEVAKSELPTLPSLNFEYKEIYTPEKKSVKEVSDFLGLSEKYFIKTLIVISEKNGPVLVMLRGDQELNEKKLARIIGEFSFATSEQALEILGVELGFVGPVGHKIKKIADFSIQKEISYISGANKKNYHLQGIIPGIHFDAQWADIRRVKEEDRCPKCGNSLKIEKAIEVGNIFKLGTKYTEPLHAYFLDKDGKEKPIIMGSYGIGPARVAAAAIEQNHDSDGIIWPKSISPFDIEIIPLNMDDEKTVSIAEELYEKVTEIYNSFADRHMEVLIDDRDERPGVKFKDADLIGIPIQIVIGKKGLKENKVEIKKRRTKETKKVSVNKAVVEIVNSYYETY | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 65392
Sequence Length: 571
Domain: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
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Q3SH24 | MRTTQFFLSTTKEAPSEAELVSHKLMLRAGLIKRLGSGLYTWMPLGLRVLRRVEAVVREEMNRAGAIELLMPAVQPAELWQETGRWAQFGPQMLKIKDRHEREFCFGPTHEEVITDLARREIKSYRQLPLNFYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHASRESLAATYQAMYDAYGRIFTRLGLRFRAVAADTGAIGGSASHEFHVLADSGEDLIAYCPDSDYAANVELAEALAPAAARGAPQEAMREVETPKQTTCEDVAALLGIPLARTVKLIAVMAGERMVVVLLRGDHMLNEVKLAKIEGLADFRLANEAEIRAVFDCPPGFLGPVGIDRSTIRVIADRAVAVMSDFVCGANKPKFHLAGVNFGRDLQEPDLVADIRNVVAGDPSPDGKGTLALCRGIEVGHVFQLGNKYSQAMNATYLDEAGKAQAMEMGCYGIGVSRIVAAAVEQNHDGKGIVWPASMAPFSVVIVAIGYGKSASVKNAADTLYADLMAVGVEVLLDDRDERPGVMFADAELVGIPHRVTLGERGLNEGVVEYQPRRAAPEQGADARKIAVAEAKAFLMGVLGD | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 62954
Sequence Length: 576
Domain: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
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Q73KJ8 | MKMTQMYMPTLREIPNEAVVESHKLLLRAGMIRNLANGLFAYLPLGLKAFRKVEKIIREEMDAIGCLEFKPPVIVPGEIWQESGRWDSMGPELLRIKNRLNQELVVSPTAEEAFTALLKNELSSYKNYPLLTYQINTKYRDEIRPRYGLMRTREFTMKDAYSFHTNDKSLDEAYLSFEKAYIKIFKRCGLTVIGVKADSGAMGGSGSQEFMVESSVGDDTLLLCPSCGYAANEEKAACAPDKEQGNGNMPQGSALSIEEIDTPNVKTIEDLTAFLKTESSSFIKTLIYRVENSEILGNAENGKKAAKNENKTVLIAVCIRGDLEVNEAKLKSSLKASDAILASDTEVEEATGTIVGFAGPVGLKNIPVIADESVMLMHDAVTGALKKDKHLLHVEPSRDFTPAHVFDLRTVRAGDKCAVCGTALYTKKGNELGHIFKLGYKYTKAMNMTYLDENGKQQHPSMGCYGIGLDRLTASIVEEHHDEDGIIWPMSIAPFQVAIVPIKYEGEMQKEADRLYEECKKRGIEALLDDRKERTGVKFKDMDLIGIPIRLVVGEKNLPNIEFKLRKAVESSLVDKDKVVDLVEKTVKEELAKLN | Function: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Catalytic Activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Sequence Mass (Da): 66299
Sequence Length: 595
Domain: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
Subcellular Location: Cytoplasm
EC: 6.1.1.15
|
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