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A0QJU9 | MSSPDQDPREAIAQGDDEVIDVRRGMFGAAGTGDTSGYGRLVRTVTLPGSSPRPYGSYFDDVVDTLTESLQSNGIEFHQAIEKVVVYRDELTLHVDRAALPHVAQHLRDDPRLRFEMCLGVSGVHYPHETGRELHAVYPLQSITHNRRVRLEVAVPDGDPHIPSLYRIYPTTDWHERETYDFFGIIFDGHPSLTRIEMPDDWHGHPQRKDYPLGGIPVEYKGAQIPPPDERRAYN | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 26636
Sequence Length: 235
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q1AVI6 | MLREERRAAEEAITLIRPATSRLVDPDIRDEFGLETLDMNMGPQHPAMHGLLRLILELDGETIVRCDPVMGYLHRCQEKIAENRTYPAVIPLTDRLDYFANMHNEHGYCLAVEDLLGVEIPPRAEYIRVLMCELMRIASHLPSIGFLLLELGAFTPILYAFRERERIQNFFEAVTGARMMFHYIRIGGVKADLPPDIPEKIWEYVEGLEKRIKPDFIDLIEGNEIFIERTRGISRLTQEEAIELGLTGPPLRCTGVAFDVRRDYPYSVYPELDFEVVTDTAGDVEASYRVRIKEVYESIKIIRQCLEKMPEGEVMGDVGRRVRPPEGEGFGRVEGPRGEFAVHVVSDGSDTPYRVHYRDPSFVNMQLLQEKMPGHYLPDIMPIMGLVDPVSGGWDK | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 45264
Sequence Length: 396
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q2S5J0 | MPQTQKPDFPGNDLGDQFRFWPKHNEKIYERLENKHAWLEEKRAAAQGDGKPPATQRSEVDPLENEMILNIGPQHPATHGVLRCVVKMDGETIEKSVLDIGYLHRGIEKLAEHKTYQEFMPYTDRMDYLSPYSNNVAWCLAVEKLADIEVPERAQWIRMIMSELARISSHCLWLGVGMMDAGAVSGFVWTFQEREEIYSIMDEVAGARFTVSHSRIGGVANDFSPRAIEMIRDFVDTFPDRIAGWEGLLNKNRIWVERNKGVGRVTKEEALELGLTGPNLRGSGVPYDVRRFEPYLKYDEVDFTIPVREEGDCLARYFLRLDEMKQSVRIIEQCLDRMTEGPIRSDDAKEAYPSKEEVYYSMEGMIHDFMYTDVGTVPPKGAHSYHAIEGPKGELGFYLTSDGTGRPWRVRINAPSFTNLQAMEHMLEGEMVADTVVIIGSLDPVMGEADK | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 51380
Sequence Length: 451
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q1GTK0 | MFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEIIERVDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPARAQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFELREDCLNFFERASGARMHSAYFRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALAWGFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIKQCLRDMPTGPIASLDRKVVPPKRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLADTTAIIGAIDVVFGECDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 45702
Sequence Length: 405
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A0LEQ1 | MPKRFLAPVTEQIYTLNLGPQHPSTHGVLRVLLDLDGEFIVKADPVIGYGHRGHEKMGENRLFKQFLPNTSRLDYLSGFLFNHGYVLAVEKLAGIPVPPRAQFIRTICSEFNRIASHLLWFGTYVMDLGGFTPFLYAFDDRERILDILDWVTGSRLTYSYCRFGGVDRDIDTRFTDMARDFIKRLRSRWPDYHNLVTRNIIFIHRTRGVGVITPEQARQFGVTGPNLRACGIAFDTRKAEPYEVYDQFDFEIPVGSDGDALDRYRVRFEEMEQSLRIIEQALDRLPGGPFMNDSVPTRLKPPKGEVYFAFESARGQAAYYLVSDGTPSPYRCHIRVPSFGNLHVLTEVLRGTLVADAISILGSVDLVIPEIDR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 42531
Sequence Length: 373
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q8A0F7 | MFDFSIVTNWIHEMLLSVMPEGWAIFIECIAVGVCIVALYAILAIVLIYMERKVCGFFQCRLGPNRVGKWGSIQVICDVLKMLTKEIFTPKDADRFLYNLAPFMVIIASFLTFACIPFNKGAEILNFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMRSGAQIISYELSVGMSIMTMVVLMGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAGNAECNRGPFDLPEAESELTAGYHTEYSGMHFGFFYLAEYLNLFIVASVAATIFLGGWMPLHIIGLDGFNAVMDYIPGFIWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPISMVNLLLMACCVAFGFHF | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 40161
Sequence Length: 358
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q6MGN3 | MGMGKDIFEITVNGLKLVVIFLMMVQAVPILVWLERRGSAFIQDRLGPNRVGPLGLVQLLADAVKFLNKENFMPQTAKPFLYYAAPIFALIPGAVAFSAIPLSSPIQVGTFEMFGSTWGPYTFLVQGYDIGVGIVFILGVSSLAAYTLLMAGWGSGNKYTLMGALRASAQTISYELALGLSIVGVIMLYGTFNLTEMTLAQQGPLAFSFLGHTITANWLPNWGIFYQPVGALLFFSAAFAESNRLPFDLAEGESELVGGFHTEYGGFKFNMFFIGEYGHMMIASGLMVLFFFGGYTIPYVSVAELNEWAAGVASTAGKASALVALIHFLVFNIKFGFFMWVFIWVRWTLPRFRYDQLMDLGWKTMLPWALANTIITAFVIYIASL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 42403
Sequence Length: 385
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
B3CUK2 | MTICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPSLAGPFGLLQPIADAVKLVFKEPIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLSRIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRSAAQMISYELAMALSIVAVLIVTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNVEYSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLFCFLWIRATLPRYRYDQLMYLGLKVFLPIVLAWIIVVSAILVYSNNLP | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 38513
Sequence Length: 347
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
A1B487 | MAEFWASPYGFALSMLLQGLAVIAFVMGSLIFMVYGDRKIWAAVQMRRGPNVVGPWGLLQTFADALKYIVKEIVIPAGADKFVYFLAPFLSMMLALFAFVVIPFDEGWVMANINVGILFIFAASSLEVYGVIMGGWASNSKYPFLASLRSAAQMISYEVSLGLIIIGIIISTGSMNLTAIVEAQRGDYGLLNWYWLPHLPMVVLFFVSALAECNRPPFDLVEAESELVAGFMTEYSSTPYLLFMAGEYIAMYLMCALLSLLFFGGWLSPVPFIADGWWWMVIKMWFWFYMFAMVKAIVPRYRYDQLMRIGWKVFLPLSLGWVVLVAILARYEILGGFWARFAVGG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 38841
Sequence Length: 345
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
A7HY42 | MTDVLIAYGIPLAIIAAQSLALIVALLLVTAYVLLADRKIWAAVQLRRGPNVVGAFGLLQSFADLLKFVFKEIVIPAGANKGIFLLAPLVTVVLALSGWAVIPLDARMVIADINVGILYIFAISSLGVYGVIMAGWASNSKYPFLSALRAAAQMVSYEVSIGFVIVCVLMTAGSLNLTAIVESQRTIWYFIPHLPMFVIFFISALAETNRPPFDLAEAESELVAGFMVEYSSTAYMMFMLGEYVSILLMCAMTTILFLGGWLPPIDIAPFNMVPGVIWFLLKVFLVFFMFAMVKAFVPRYRYDQLMRLGWKVFLPISLFWVVLTAGVLVGFDIVPQH | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37120
Sequence Length: 337
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q6MDQ9 | MIDDLIIILIKSAVVILLLFTAAAYMTFLERIVMARLQLRMGPVRVGPFGLFQPLADGIKLLCKERFQPANVETFVYWLAPGISLFTALFIFVLIPFGGVVEIAGRLIYLQIADINVGVVFLLAFSSLAVYGVVLAGWASNNRYSLIGGLRGTAQMISYEIPMGLSLLTVVLSTGTLSLREIVELQQNHWLIWTNPISFIIYFITSFAETNRAPFDLPEAEQELTAGYHTEYGGMKFAAFFLGEYINILAVSAIATTLFFGGWHGPGDIPILWFGLKVAIFVFIFMWVRATMPRFRYDQLMSFGWKVLIPIAILNLIITAYFTLV | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36351
Sequence Length: 325
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q4FM84 | MEYLNIIFLQTYKILFLLVPVLVSVAMIVWLDRRIWAFVQKRQGPNVVGPFGLLQSLADALKYIFKEVIIPSSSNKVIFILAPIVTMTLALVSWAVIPFSTTQVLADINVGVLYLFAVSSLGVYGIIMGGWASNSKYPFLGAIRSAAQMVSYEVSIGVIIINVLLCVGSLNLNDIIMAQENLWFIIPLFPMFVIFFISALAETNRPPFDLPEAEAELVAGYQTEYSGMMYAMFWLGEYANILLMCAMGSILFLGGWLSPIDLYPFNLIPGAIWMIFKILFLFVLFALVKAVVPRYRYDQLMRLGWKIFLPLSLTWVVLTASYLFYFNLLPVN | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37447
Sequence Length: 332
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q6MIR9 | MSVMQNNSEKSKWFLPGILGGLATTMKHLLKNLFNQKKMMTLNYPEEKYEYSPRFKGNHVLTVKKDGSLRCTACMLCATNCPAECIKITAAEHNDPTVEKFPISYEIDILRCVFCGFCEEACPVDAIRLGPEWQTPGVNGANFIYDINHLAYRPNLKGGILTHVDDEERHKAGI | Cofactor: Binds 2 [4Fe-4S] clusters per subunit.
Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 19614
Sequence Length: 174
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C5D981 | MSSVPLSVYLVLALILFCIGLYGALTKRNTVIVLICIELMLNAVNINLVAFAKYGAHPGIAGQIFALFTITVAAAEAAVGLAILMALYRNRKTVHIDEIDSMKH | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11203
Sequence Length: 104
Subcellular Location: Cell membrane
EC: 7.1.1.-
|
A9HN78 | MIMRPTPDMAMLLAAGLFALGLLGVLVRRNLLFMLMSIEIMLNAAALAFVAAGTRWHAAEGQVMFLMILSLAAAEAAIGLAILLRMHQAGRPTLDADTGNRLKG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11075
Sequence Length: 104
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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O25860 | MIGLNHYLIVSGLLFCIGLAGMLKRKNILLLFFSTEIMLNAINIGFVAISKYTHNLDGQMFALFIISIAASEVAIGLGLVILWFKKFKSLDIDSLNAMKG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11009
Sequence Length: 100
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
B3E9V9 | MDNLSNYLIVSAVLFSIGTIGVLTRKNAIVVFMCIELMLNAVNLTFVAFSRHLGNLDGQIFVFFIMTVAAAEAAVGLALFIAFFNNRESIDIDDANLMKW | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 11037
Sequence Length: 100
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
A1JLI8 | MIPLQHGLILAAILFVLGLTGLIIRRNLLFMLISLEVMINAAALAFVVAGSYWGQADGQVMYILAITLAAAEASIGLALLLQLYRRRHTLNIDTVSEMRG | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 10879
Sequence Length: 100
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q0APX7 | MTADMLSHDLSLLIPELVLAGGAMALLMLGVFLKGDGTEKLVQWLTVGLLAAAALAALFLVSGEGMAFNDSFVFDSLARFSKTAIGLVAAIAMLLAMPYLQAEKLGKIEYPVLVVLAVTGMMMMVSANDLIAMYMGIELQSLALYVLAAFNRDSLRASEAGLKYFVLGALSSGLLLYGASLVYGFAGSTGFGDIALAVESGSNIGLTVGLVFVICGLAFKVSAAPFHMWTPDVYEGAPTPVTAFFATAPKFAAIVLLARVLMEPFGAVVDQWRDVIWMIAVLSMAVGAFGALTQQNIKRLMAYSSISNMGYALVAVAAASQTGLWALLVFMVLYMVGAIGSFATILSMRTREGMVEQISDLAGLAQRNPGLGWSMTALMFSIGGLPFMVGFFGKFFVIYAAVQADLMILAVLAVLFSVVGAAYYLRIVKVIWFDSSEIEFVPSAVSTYWIARIAGLATVLLLPVLGWLVFRAYSVGLALL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 50982
Sequence Length: 480
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
Q608Y9 | MTTDALTALLPFIVLSAAAVAVMLAIAIRRSFRLVFWLTVGGLLAGLSTLPHASSVAPLQVTDLLRVDAYGLFFHALFLLAALVVALLCLAYFRRRENENEEIFVLLLTSTLGALLLVSSAHLAMFFLGLEVLTISLFPMIAYSVRASRPLEAGIKYLMLSGLASSFLMFGMAMVYGDLGVLSFEQIGAHGAELEQKPLALAGLFLILAAIGFKLSLVPFHLWTPDVYQGAPTPVTAFLATVSKASVFALLLRFFTAAHAERSETFLCVLGLLAVVSILAGNLLALLQVSLKRLLAYSSIAHMGYLLTGFVAAGLLRRDLQTETIAFYLAAYTVTSLTAFGAISALSDDDRESDRLSDYAGLFWRSPWLAAVLTLSLLSLAGIPLTVGFVGKFYVFAVGVQAETWPLVATVVIGSGIGIYYYLRVVLTMIQPAGVGQRVTLHPAAGTALAAAALVILAAGLFPQPLIDAAANVPQPPPTADSPQRLTATGGLP | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52350
Sequence Length: 493
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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B3DZT0 | MNAFFVFCTPECFLSLSALVLLLWQALAKIHDKSIGILVLADYLVAGVLLLPFVENQGIFWNGLYVWDKMAVLWKVFFLITGFLVSYLSLESDRLIPKARSEFYILPLFTTAGMALLASVRDFILLFVGLEIVTVSFYVFVAFQREFPSALEAGVKYLIIGALASSFLVMGIAFVFGITGSTQFDEVARFAQNNPVNGPLILGLVFILVGLGFKASAVPFHVWTPDVYQGASTPITTYLAVGSKAAGFVVLLRILNLPFYDPGFQKHWIPLISLMALLSVIVGNLAAIPQRNIKRMLGYSSISHGGFLLMGLSAHNKIGCAAVIYYFFAYMVAIFAAFLVVILLEKNQPSGVSIKDFNGLYLKNSLMAWSMAFSMISLAGLPPLMGFFGKLMVFFAAWDSGQHLLVIVGALCAAAGLYYYIGVVRAMFWTEPDNVQRIDLSPATKLLLWILSVGSILLGFYAEPVIKLVGSVLS | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51980
Sequence Length: 474
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
|
P0A5M1 | MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 55342
Sequence Length: 531
Subcellular Location: Cell membrane
EC: 7.1.1.-
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A3Q537 | MNPEEAMRPLLMASEMMMFGAGLVALIAGSFLRRQRQWWVGVMAAAAQVGVIGVAVVQMVGPDQMAFEGAFSVDTATGVARIACAAGLLLIWAVAGAEMRASPREAETYALLMFSATGVLVLAGAEDLLLLVAGYFLASIPLYGLVGLARSAAAAEAAMKAYLMGALFGILLMLGVTILYGLTGATRYPQLAMTLSGAPAVAVAAGVVGVLAGLMFEAGGVPAHFWVPDAAQGANATAATFLTTVPKIGALVALYRLTTVLPDTLAWPVLIAVFAVISMTLGNLAAYWQQDPRRLLGWSTVSQVGYLLVPITVAGASELALPSLLFYLGGYTVTNIAAFAVTAALPGRRDLDSYRGLARTRPWLAAALVVALLGLVGTPPTAVFIGKVTTAAAAWDGRYAWLAVVVFVNTLVSLFYYLRWIIPAFGRPHETGDADQSAVQHWPARVAVLAAALSLLLGIIAGPVWQLVT | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 48950
Sequence Length: 469
Subcellular Location: Cell membrane
EC: 7.1.1.-
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Q1DDD3 | MNLPNLSLADFLPLLPAIIMVVGASILLLSEVFLSTTASRAYQAVLTVVTAVAAGAMALTTMFEPPQEVMLGFGVMDPFSSFLTFVVCVGLGLATLSSVSFLRKRGAERGEFYALMLFASAGMSLLAMSNELITLFVNIEVLSLSTYALTSYLRRGTRPSEAGFKYFILGAFSSAVLLYGAALLYGATGTTHLTAMAGPLSTAMSSQPGLVYAGIILVITGFAFKVAAVPFHMWTPDVYEGAPTPVTALMSVGVKAAAFAAMVRVFFMVGKGVDPQMLLGLFSVLAFLTMVAGNLLAIPQRNVKRMLAYSSIAHAGYLLVGVAALFVTGPGEQFRLLGASALTGGTPLGLARAEALRGILYYLLAYTFSAVGAFAIVSVLERREDEEKGTAWDLERFSGLAQRKPGWAFAMAAFMLSLGGIPPTIGFMSKLLIFQAAVDAGLIGLTIVGVLSSAVGIYYYLRVVVYMFMRPVPEGAQALEKSWSTELALVLSTAAVVILGIIPGPIMGWLEQASSIFGQ | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 54859
Sequence Length: 519
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q5F629 | MNWSDLNLMPALPEVALLSLLVLLLPADLWASDDKCRWTHYGALATVAVTAAVQLAVWEQGSTSSFNGMYIADGMSRLAKMVLYALTFVLFVYAKPYNQVRGIFKGEFYTLSLFALLGMSVMVSAGHFLTAYIGLELLSLALYALIALRRDSGFAAEAALKYFVLGALASGLLLYGISMVYGATGSLEFAGVLASSFNEEANEWLLKLGLVFIVVAVAFKLGAVPFHMWMPDVYHGAPTSVTALVGTAPKIAAVVFAFRILVTGLGTVHHDWSLMFALLAAASLLVGNLAAIMQTNIKRMLAYSTVSHMGFILLAFMAGAVGFAAGLYYAITYALMAAAGFGVLMVLSDGDNECENISDLAGLNQHRVWLAFLMLLVMFSMAGIPPLMGFYAKFGVIMALLKQGYVWLSVFAVVMSLVGAFYYLRVVKVMYFDESGRARPAAGGNNAAKSLLSVNALLLVLWGIMPQTVIDWCAKALENTL | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 51833
Sequence Length: 481
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C6V5H7 | MNQYLFLLPEITLFILSCLLLFLKSRNEFGLIAVLITLAATFFSQTCTSVEILNGMLLISPFTQNVKLVILAFTCVFFIQAIAVKQSYSKNFSVLVLLSLLGMLLSVSSSTLASLYLAVELHSIGQYILACIKHKSIKSAEAGVKYTLLGTFMSAVMIYGISLIFVVSGDLSLKSLFIANSKIHSIGILLFISGLMFKVAAAPFHAWIGDIYEGAPTVSTTFFAVLPKLSLIVVLVSLISNLEPIAYTGSTYSTELMENSQYLRNILFTSGILSIAFGTFSAFGQKNIKRFIGFASIAHVGYMLLGVSNSASLSFGNPGIAYALVYSFTNLGILSVVLMLKDKHITSLKKLRCSNNLVALAFVLLLFSSAGVPPFIGFWSKAYVVKTLVETNHIPTAIFSMLAGVISAFYYARIAKETYFTNMAEENIEASLRHNTLLTSIVVLCALFSTFGFVLLIY | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 49975
Sequence Length: 458
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q82TV6 | MDFLLPDFTPAYPEIFLLLMVCVVMLADLFAGERNRYLAFYLSLLTLAGCALVTCGIYSTEVRYTFTGMFVGDAMSDILKLLIYVTVAAVLIYSRSYISTRGLLKGEFFSLALFATLGMMVMVSANHLITLYLGLELLSLSLYAMVALQRESAIATEAAIKFFVLGALASGFLLYGMSMLYGATGTLHLPELAKVIHSGQADHEIFIIGLVFVVAGIGFKLSAVPFHMWAPDIYEGAPTAVTLFIGSAPKFAAFGFVMRLLVGGLGDLVTDWQGMLVLLAVASMAVGNIAAIAQQNIKRMLAYSTISHMGFVLLGFIAAGENGYSSSMFYVIAYVLMTLGAFGIIMLVSREGFEADKISDLKGLNQRNPWLAFMMLLVMFSMAGIPPMIGFYAKLSVLQAVLEAGYIWLVVVAVMLSLIGAFYYLRIIKFMYFDAPEQTQPIMFKPDVKVLVSINGLAIILLGMFPQMLMGLSLSAIQHSM | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52461
Sequence Length: 481
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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Q2YA93 | MNPMPSALPSDFLHVDLVTLSPLILLAAAAVVVMLTAAFYRHPRPVMILTLAGLVLSFMALFLSQGTASSQVTTLLILDQYALFFIGLIVVATFVVAILCYRYFGGGESRHEALYILLLLAALGGGVLVASSHFASFLLGLELLSISLFALIAYPRFTEHPLEAGIKYLILAGFSSGLLLFGMALVYAQLGTMQFVKIGTMLAAPGAALELYGLAGLALIVTGVGFKLALVPFHMWTPDVYEGAPVPITAFIATASKGAMLVLLLRYFLMAGAHQSHSITFALSLIAVATILVGNLLALLQNNIKRILAYSSIAQLGYLLVGFLAFDQLAIEAVAYFLTAYFVTMLGAFGVVTVLSEGFNGGSAGEFHDAGEKDSDRLADYAGLFWHRPWLAGVFTAMLLSLAGIPLTMGFIGKFYIVTAGVEASLWMPVITLVIGSIIGLFYYMRIIAVMYGWGPEAAGEAIMLRAASPSFAESATLAALALLLIWLGIFPAQLIGVLEGAGGGLT | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 53746
Sequence Length: 507
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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A1SE40 | MDFIKPTIEYGDVWPLLVVFGVAAVGVLVEGFVPRAQRYLVQAALAIAGVVVALVGTILVARDLDVLGDGAARGAIDVEGTIAVDGPALFIWGMLLVFALGGALLFAERRLEGGVSAFAGQAAALPGTEAERQASTRGLEHTEVYPLMMFALGGMMLFAAANDLLTLFVALEVLSLPLYLLSGLARRRRLLSQEAALKYFMLGAFSSGFFLYGAALVYGFSGSMGFAEINEAVRDDVGNQTLLLIGIGMLSVGLLFKVGAVPFHSWTPDVYQGAPTAVTAFMAAGTKIAAFGAMLRLFYVAFGSDRWSWQPMLWIIAILTMLVGALIAIVQTDMKRMLAYSSVAHTGFLLTGVLGVQQASELADGEVTSLQAVLFYLVTYGFAVVGAFAVVTLVRDAGGEAGQFVRWRGIGRRSPLVAGVFAFFLLSMAGIPLTAGFVGKWAVFTVALAAGAWPVVIAAVLCSIIAVFFYVRVILLMFFEDDDVSAQGEVASVTKPSVLTSATIFVGVAATLVLGVVPGPVLDLAANAGQFVR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 56131
Sequence Length: 533
Subcellular Location: Cell membrane
EC: 7.1.1.-
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B3CUJ6 | MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGIYWNNTFIVNQSKIYLKIIILIFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILVSANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYFILGTVFSAIMLFGISLVYGTTQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVALFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFIAYSAILNLGYAVLALVANSSNVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKISHLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFTSILKSGMYELIIMGIAAVVIGSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 52679
Sequence Length: 479
Subcellular Location: Cell inner membrane
EC: 7.1.1.-
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C6D5D2 | MTEFVPLTWHDTLYLAPELILAAMFLILIVTDLILPGRTNRAIIGWLSLAGLLLSLAAVIWRMIDMNPSGVSAAEAAEAGKAISLLGASYRVDDYGNLLKIIFLIGTSLVVLLGLGSTQKDDAVTDKAEFYYLLLPAAAGAMIMASSGNLVTLYIGLELLSITTYVLVGLRKRSSLSAEAAFKYVVTGGIASAFVLFGMSYLYGVTGSVSLADFPTALPQAFTDYKALVYVGFFFLIAGFGIKIAAAPFHIWAADVYQGAPTPVSAFLAVIAKGAALAAVFRFLYSSAFFLTGGPGKQAGDDVFFALLVIAAAAMIAGTVSALRQKQVKRLLALSGVANAGYLLVPIAISVTIIHSNNFSEFVFYLVAYLLMNVGAFAVVTVIARAAGHEELKGFSGLYYRAPWTAAAMLIFILSFSGLPVTAGFFGKLFILLGAASVKAYWLVAIMVVSTVISYYFYFGIIRQMFMRSNGEEEDRIHVPAVTGTVIWICAAATVALGVLPGPLMKWIDAVFTIQADLFVR | Function: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic Activity: a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 55623
Sequence Length: 521
Subcellular Location: Cell membrane
EC: 7.1.1.-
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A2RKA7 | MANETVIQMIDVTKRFGDFVANDKVNLELKKGEIHALLGENGAGKSTLMNILSGLLEPSEGEVHVKGKLENIDSPSKAANLGIGMVHQHFMLVDAFTVTENIILGNEVTKGINLDLKTAKKKILELSERYGLSVEPDALIRDISVGQQQRVEILKTLYRGADILIFDEPTAVLTPAEITELMQIMKNLIKEGKSIILITHKLDEIRAVADRITVIRRGKSIDTVELGDKTNQELAELMVGRSVSFITEKAAAQPKDVVLEIKDLNIKESRGSLKVKGLSLDVRAGEIVGVAGIDGNGQTELVKAITGLTKVDSGSIKLHNKDITNQRPRKITEQSVGHVPEDRHRDGLVLEMTVAENIALQTYYKPPMSKYGFLDYNKINSHARELMEEFDVRGAGEWVSASSLSGGNQQKAIIAREIDRNPDLLIVSQPTRGLDVGAIEYIHKRLIQARDEGKAVLVISFELDEILNVSDRIAVIHDGQIQGIVSPETTTKQELGILMVGGNINE | Function: Part of an ABC transporter complex involved in the uptake of all common nucleosides . Responsible for energy coupling to the transport system (Probable).
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 55544
Sequence Length: 506
Subcellular Location: Cell membrane
EC: 7.6.2.-
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A2RKA6 | MNNKTRKVLVPLIAIVFGFLLGAIIMLAFGYNPIWGYEDLFISALGSARSIGETLQTMGPLILTALSFAVAMKVGLFNIGMSGQALAGWISSMWFALSFPDIPRLLMIPLVVIIGMVFGAFMGFIPGILRALLGTSEVITTIMLNYIMLFFSTFMIHSMFQKNILMDNTTDQTKLISANASFRTNWMSSLTDNSTLNIGLIIAIIALVIMAIIFTKTTLGFEIKAVGLNPDASEYAGISAKRTLILSMVVAGALAGLGGVVYGFGYMQNFVSQSASLDIGFYGMAVALLGGNSPIGILFAALLFSVLQTGAPGMTNDGIPPEIVKVVTAAIIFFIAVKFIIEVMLPKAKAIKASEATKKKGEKA | Function: Part of an ABC transporter complex involved in the uptake of all common nucleosides . Responsible for the translocation of the substrate across the membrane (Probable).
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 38876
Sequence Length: 364
Subcellular Location: Cell membrane
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P0AFF3 | MDRVLHFVLALAVVAILALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFGSMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVIIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKISRNRMYTMAATAMSTVSMSIVGAYMTMLEPKYVVAALVLNMFSTFIVLSLINPYRVDASEENIQMSNLHEGQSFFEMLGEYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPIAWVMGVPSSEALQVGSIMATKLVSNEFVAMMDLQKIASTLSPRAEGIISVFLVSFANFSSIGIIAGAVKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL | Function: Nucleoside transport protein that can transport adenosine, uridine, thymidine, cytidine and deoxycytidine (By similarity). Transport is driven by a proton motive force (By similarity).
Catalytic Activity: adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 43476
Sequence Length: 400
Subcellular Location: Cell inner membrane
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O25792 | MIFSSLFSVVGMAVLFLIAWVFSSNKRAINYRTIVSAFVIQVALGALALYVPLGREMLQGLASGIQSVISYGYEGVRFLFGNLAPNAKGDQGIGGFVFAINVLAIIIFFASLISLLYYLKIMPLFINLIGGALQKCLGTSRAESMSAAANIFVAHTEAPLVIKPYLKSMSDSEIFAVMCVGMASVAGPVLAGYASMGIPLPYLIAASFMSAPGGLLFAKIIYPQNETISSHADVSIEKHVNAIEAIANGASTGLNLALHVGAMLLAFVGMLALINGLLGVVGGFLGMEHLSLGLILGTLLKPLAFMLGIPWSQAGIAGEIIGIKIALNEFVGYMQLLPYLGDNPPLILSEKTKAIITFALCGFANLSSVAMLIGGLGSLVPKKKDLIVRLALKAVLVGTLSNFMSATIAGLFIGLNAH | Function: Involved in purine nucleosides uptake. Could also be involved in uptake of nucleobases.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 43807
Sequence Length: 418
Subcellular Location: Cell inner membrane
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P42312 | MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITWFMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVTFFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVLSNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPEDEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHGLTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHTVAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIVGLFVW | Function: Involved in the uptake of the purine ribonucleosides inosine and guanosine.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 43719
Sequence Length: 397
Subcellular Location: Cell membrane
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P0AFF4 | MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGASIGAVYSSLGIAAVFMPALLGIVADKWLSAKWVYAICHTIGAITLFMAAQVTTPEAMFLVILINSFAYMPTLGLINTISYYRLQNAGMDIVTDFPPIRIWGTIGFIMAMWVVSLSGFELSHMQLYIGAALSAILVLFTLTLPHIPVAKQQANQSWTTLLGLDAFALFKNKRMAIFFIFSMLLGAELQITNMFGNTFLHSFDKDPMFASSFIVQHASIIMSISQISETLFILTIPFFLSRYGIKNVMMISIVAWILRFALFAYGDPTPFGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVSPAIRASAQGMFLMMTNGFGCILGGIVSGKVVEMYTQNGITDWQTVWLIFAGYSVVLAFAFMAMFKYKHVRVPTGTQTVSH | Function: Broad-specificity transporter of purine and pyrimidine nucleosides . Can transport adenosine, uridine, thymidine, cytidine, deoxycytidine, guanosine and inosine . Can also transport xanthosine, but with a very low affinity . Transport is driven by a proton motive force .
Catalytic Activity: adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 46389
Sequence Length: 418
Subcellular Location: Cell inner membrane
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P05221 | MASTVSNTSKLEKPVSLIWGCELNEQDKTFEFKVEDDEEKCEHQLALRTVCLGDKAKDEFNIVEIVTQEEGAEKSVPIATLKPSILPMATMVGIELTPPVTFRLKAGSGPLYISGQHVAMEEDYSWAEEEDEGEAEGEEEEEEEEDQESPPKAVKRPAATKKAGQAKKKKLDKEDESSEEDSPTKKGKGAGRGRKPAAKK | Function: Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores . Involved in chromatin remodeling, especially during fertilization and early embryonic development (By similarity). May be involved in sperm chromatin decondensation during fertilization .
PTM: Activated by phosphorylation of multiple serine/threonine residues, along both core and tail domains. The level of phosphorylation gradually increases during egg maturation, reaching an average of 7-10 phosphates per monomer, so that at the time of fertilization the activity of the protein is maximum.
Sequence Mass (Da): 22024
Sequence Length: 200
Subcellular Location: Nucleus
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O05252 | MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMVTDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENFDLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAALSSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAESMYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNVTLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVDKWKKKIIDGLEIPATEKELKTFKAE | Function: Part of an ABC transporter complex involved in the uptake of guanosine . Is probably the substrate-binding protein of the system . May be a nucleoside transporter of broad specificity but with various affinities for different substrates .
Location Topology: Lipid-anchor
Sequence Mass (Da): 38361
Sequence Length: 359
Subcellular Location: Cell membrane
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O05254 | MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGIFGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGPAYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLTDHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRAVGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDGIAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYAIRFVMGKLKKKGAN | Function: Part of an ABC transporter complex involved in the uptake of guanosine . Responsible for the translocation of the substrate across the membrane (Probable). May be a nucleoside transporter of broad specificity but with various affinities for different substrates .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36844
Sequence Length: 348
Subcellular Location: Cell membrane
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O05255 | MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGLMIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGVAINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSILAIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGGVYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPLFKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR | Function: Part of an ABC transporter complex involved in the uptake of guanosine . Responsible for the translocation of the substrate across the membrane (Probable). May be a nucleoside transporter of broad specificity but with various affinities for different substrates .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 33738
Sequence Length: 319
Subcellular Location: Cell membrane
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Q12255 | MKRFNVSYVEVIKNGETISSCFQPFQKNENYGTITSANEQITPVIFHNLIMDMVLPKVVPIKGNKVTKMSMNLIDGFDCFYSTDDHDPKTVYVCFTLVDMPKILPIRILSGLQEYESNATNELLSSHVGQILDSFHEELVEYRNQTLNSSGNGQSSNGNGQNTISDIGDATEDQIKDVIQIMNDNIDKFLERQERVSLLVDKTSQLNSSSNKFRRKAVNIKEIMWWQKVKNITLLTFTIILFVSAAFMFFYLW | Function: Vacuolar v-SNARE required for docking. Only involved in homotypic vacuole fusion. Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step.
Location Topology: Single-pass type IV membrane protein
Sequence Mass (Da): 28964
Sequence Length: 253
Subcellular Location: Vacuole membrane
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P35898 | MKQQNDTQILQFLLLGLSENTELQPLIYWLFFSMYLVTVWGNLIIILATVLDFRLHTAMYFFLCNLSFVDICLISTTIPKMLANVHLNHKAITYEGCIMQIYFFTLFVGLDNFLLAVMAYDRFVAICHPLRYTSIMTPHLCMSLVLVSWIASVLNSSLQSFLVLQLSFCTEVEIPHFFCELSMLVHLACSDTFLSDMAMNVLAALLGGGCLVGILYSYSKIVSSIQAISSAEGKYKAFSTCVSHLSVVSLFYCTLLGVYLSSAVTQNSHSTAATSLMYTVVTPMLNPFIYSLRNDNIKRALKNFVKKKLEK | Function: Possible taste receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35013
Sequence Length: 311
Subcellular Location: Cell membrane
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P58181 | MKRQNQSCVVEFILLGFSNFPELQVQLFGVFLVIYVVTLMGNAIITVIISLNQSLHVPMYLFLLNLSVVEVSFSAVITPEMLVVLSTEKTMISFVGCFAQMYFILLFGGTECFLLGAMAYDRFAAICHPLNYPVIMNRGVFMKLVIFSWISGIMVATVQTTWVFSFPFCGPNEINHLFCETPPVLELVCADTFLFEIYAFTGTILIVMVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCASHLTSVTLFYGTANMTYLQPKSGYSPETKKLISLAYTLLTPLLNPLIYSLRNSEMKRTLIKLWRRKVILHTF | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35535
Sequence Length: 314
Subcellular Location: Cell membrane
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Q9H209 | MMWENWTIVSEFVLVSFSALSTELQALLFLLFLTIYLVTLMGNVLIILVTIADSALQSPMYFFLRNLSFLEIGFNLVIVPKMLGTLIIQDTTISFLGCATQMYFFFFFGAAECCLLATMAYDRYVAICDPLHYPVIMGHISCAQLAAASWFSGFSVATVQTTWIFSFPFCGPNRVNHFFCDSPPVIALVCADTSVFELEALTATVLFILFPFLLILGSYVRILSTIFRMPSAEGKHQAFSTCSAHLLVVSLFYSTAILTYFRPQSSASSESKKLLSLSSTVVTPMLNPIIYSSRNKEVKAALKRLIHRTLGSQKL | Function: Odorant receptor (Potential). May be involved in taste perception.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35117
Sequence Length: 315
Subcellular Location: Cell membrane
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Q9H207 | MAIGNWTEISEFILMSFSSLPTEIQSLLFLTFLTIYLVTLKGNSLIILVTLADPMLHSPMYFFLRNLSFLEIGFNLVIVPKMLGTLLAQDTTISFLGCATQMYFFFFFGVAECFLLATMAYDRYVAICSPLHYPVIMNQRTRAKLAAASWFPGFPVATVQTTWLFSFPFCGTNKVNHFFCDSPPVLKLVCADTALFEIYAIVGTILVVMIPCLLILCSYTRIAAAILKIPSAKGKHKAFSTCSSHLLVVSLFYISSSLTYFWPKSNNSPESKKLLSLSYTVVTPMLNPIIYSLRNSEVKNALSRTFHKVLALRNCIP | Function: Odorant receptor (Potential). May be involved in taste perception.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35519
Sequence Length: 317
Subcellular Location: Cell membrane
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Q8NH74 | MERQNQSCVVEFILLGFSNYPELQGQLFVAFLVIYLVTLIGNAIIIVIVSLDQSLHVPMYLFLLNLSVVDLSFSAVIMPEMLVVLSTEKTTISFGGCFAQMYFILLFGGAECFLLGAMAYDRFAAICHPLNYQMIMNKGVFMKLIIFSWALGFMLGTVQTSWVSSFPFCGLNEINHISCETPAVLELACADTFLFEIYAFTGTFLIILVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCAAHLTSVTLFYGTASMTYLQPKSGYSPETKKVMSLSYSLLTPLLNLLIYSLRNSEMKRALMKLWRRRVVLHTI | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35318
Sequence Length: 314
Subcellular Location: Cell membrane
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Q8NGE5 | MICENHTRVTEFILLGFTNNPEMQVSLFIFFLAIYTVTLLGNFLIVTVTSVDLALQTPMYFFLQNLSLLEVCFTLVMVPKMLVDLVSPRKIISFVGCGTQMYFFFFFGSSECFLLSMMAYDRFVAICNPLHYSVIMNRSLCLWMAIGSWMSGVPVSMLQTAWMMALPFCGPNAVDHFFCDGPPVLKLVTVDTTMYEMQALASTLLFIMFPFCLILVSYTRIIITILRMSSATGRQKAFSTCSSHLIVVSLFYGTASLTYLRPKSNQSPESKKLVSLSYTVITPMLNPIIYGLRNNEVKGAVKRTITQKVLQKLDVF | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35695
Sequence Length: 316
Subcellular Location: Cell membrane
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Q8NH08 | MDSPSNATVPCGFLLQGFSEFPHLRPVLFLLLLGVHLATLGGNLLILVAVASMPSRQPMLLFLCQLSAIELCYTLVVVPRSLVDLSTPGHRRGSPISFLSCAFQMQMFVALGGAECFLLAAMAYDRYVAICHPLRYAAVVTPGLCARLALACCLRGLAVSVGLTVAIFHLPFCGSRLLLHFFCDITALLHLACTRSYADELPLLGACLVLLLLPSVLILASYGAIAAALRRLRCPKGRGKAASTCALHLAVTFLHYGCATFMYVRPRASYSPRLDRTLALVYTNVTPLLCPLIYSLRNREITAALSRVLGRRRPGQAPGGDLREL | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35157
Sequence Length: 325
Subcellular Location: Cell membrane
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Q8NGE0 | MLRNGSIVTEFILVGFQQSSTSTRALLFALFLALYSLTMAMNGLIIFITSWTDPKLNSPMYFFLGHLSLLDVCFITTTIPQMLIHLVVRDHIVSFVCCMTQMYFVFCVGVAECILLAFMAYDRYVAICYPLNYVPIISQKVCVRLVGTAWFFGLINGIFLEYISFREPFRRDNHIESFFCEAPIVIGLSCGDPQFSLWAIFADAIVVILSPMVLTVTSYVHILATILSKASSSGRGKTFSTCASHLTVVIFLYTSAMFSYMNPHSTHGPDKDKPFSLLYTIITPMCNPIIYSFRNKEIKEAMVRALGRTRLAQPQSV | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35698
Sequence Length: 317
Subcellular Location: Cell membrane
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Q8NH19 | MEFVLLGFSDIPNLHWMLFSIFLLMYLMILMCNGIIILLIKIHPALQTPMYFFLSNFSLLEICYVTIIIPRMLMDIWTQKGNISLFACATQMCFFLMLGGTECLLLTVMAYDRYVAICKPLQYPLVMNHKVCIQLIIASWTITIPVVIGETCQIFLLPFCGTNTINHFFCDIPPILKLACGNIFVNEITVHVVAVVFITVPFLLIVVSYGKIISNILKLSSARGKAKAFSTCSSHLIVVILFFGAGTITYLQPKPHQFQRMGKLISLFYTILIPTLNPIIYTLRNKDIMVALRKLLAKLLT | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34105
Sequence Length: 301
Subcellular Location: Cell membrane
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Q96KK4 | MSANTSMVTEFLLLGFSHLADLQGLLFSVFLTIYLLTVAGNFLIVVLVSTDAALQSPMYFFLRTLSALEIGYTSVTVPLLLHHLLTGRRHISRSGCALQMFFFLFFGATECCLLAAMAYDRYAAICEPLRYPLLLSHRVCLQLAGSAWACGVLVGLGHTPFIFSLPFCGPNTIPQFFCEIQPVLQLVCGDTSLNELQIILATALLILCPFGLILGSYGRILVTIFRIPSVAGRRKAFSTCSSHLIMVSLFYGTALFIYIRPKASYDPATDPLVSLFYAVVTPILNPIIYSLRNTEVKAALKRTIQKTVPMEI | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34384
Sequence Length: 312
Subcellular Location: Cell membrane
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P0C832 | KSTSCMEAGSYCGSTTRICCGYCAYSASKNVCDYPSN | Function: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels (By similarity).
Sequence Mass (Da): 3912
Sequence Length: 37
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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P0CY66 | AEDSRGTQLHRALRKATKLSESTRCKRKGSSCRRTSYDCCTGSCRNGKCG | Function: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin selectively and potently inhibits depolarization-activated rat Cav2.2/CACNA1B currents (IC(50)=89 nM), when coexpressed with alpha-2/delta-1 (CACNA2D1) and beta-3 (CACNB3) subunits. In vivo, is lethal to fish and displays potent analgesic activity in mice pain models of hot plate and acetic acid writhing but has fewer side effects on mouse motor function and lower toxicity in goldfish. Shows higher or similar analgesic activity in the pain models mentioned above compared to MVIIA, and lower side effects. In addition, it blocks Cav2.2/CACNA1B more rapidly than MVIIA and also dissociates more rapidly.
Sequence Mass (Da): 5511
Sequence Length: 50
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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Q9BPA9 | MEKLTILLLVAAVLTSTQALIQGGGDERQKAKINFLSRSDRDCRGYDAPCSSGAPCCDWWTCSARTNRCF | PTM: Contains 3 disulfide bonds.
Sequence Mass (Da): 7701
Sequence Length: 70
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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P56711 | MEKLTILLLVAAVLMSTQAQNQEQRQQAKINFLSKRKPSAERWRRDCTSWFGRCTVNSECCSNSCDQTYCELYAFPSFGA | Function: Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN). Triggers depolarization and firing of action potential bursts in the caudodorsal neurons of lymnaea. This effect is due to activation or enhancement of a slow inward cation current that may underlie endogenous bursting activity of these neurons.
Sequence Mass (Da): 9189
Sequence Length: 80
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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P0DOW6 | CDAPTHYCTNYWECCSGYCEHSHCW | Function: Micromolar concentrations of PiVIIA increase the magnitude of the macroscopic calcium current in DRG neurons from rat. An increase, even modest of the calcium current, may have a significant impact in the excitability and electrical activity of neurons, and may set up PiVIIA as a member of the pharmacological family of the gamma-conotoxins.
Sequence Mass (Da): 2999
Sequence Length: 25
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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P0C1M8 | APAKRWFGHEECTYWLGPCEVDDTCCSASCESKFCGLW | Function: Induces a sleep-like state in mice.
Sequence Mass (Da): 4317
Sequence Length: 38
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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P24160 | MEKLTILLLVAAVLMSTQAMFQGDGEKSRKAEINFSETRKLARNKQKRCGGYSTYCEVDSECCSDNCVRSYCTLFG | Function: Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN) (By similarity). Potent neurotoxin.
Sequence Mass (Da): 8529
Sequence Length: 76
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Subcellular Location: Secreted
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Q8NGT7 | MESNQTWITEVILLGFQVDPALELFLFGFFLLFYSLTLMGNGIILGLIYLDSRLHTPMYVFLSHLAIVDMSYASSTVPKMLANLVMHKKVISFAPCILQTFLYLAFAITECLILVMMCYDRYVAICHPLQYTLIMNWRVCTVLASTCWIFSFLLALVHITLILRLPFCGPQKINHFFCQIMSVFKLACADTRLNQVVLFAGSAFILVGPLCLVLVSYLHILVAILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSSHSQERRKILSLFYSLFNPILNPLIYSLRNAEVKGALKRVLWKQRSM | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35213
Sequence Length: 310
Subcellular Location: Cell membrane
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Q96R47 | MEGNKTWITDITLPRFQVGPALEILLCGLFSAFYTLTLLGNGVIFGIICLDCKLHTPMYFFLSHLAIVDISYASNYVPKMLTNLMNQESTISFFPCIMQTFLYLAFAHVECLILVVMSYDRYADICHPLRYNSLMSWRVCTVLAVASWVFSFLLALVPLVLILSLPFCGPHEINHFFCEILSVLKLACADTWLNQVVIFAACVFILVGPLCLVLVSYLRILAAILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVTYMAPKSRHPEEQQKVLSLFYSLFNPMLNPLIYSLRNAEVKGALRRALRKERLT | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34993
Sequence Length: 310
Subcellular Location: Cell membrane
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Q8NHA4 | MWQKNQTSLADFILEGLFDDSLTHLFLFSLTMVVFLIAVSGNTLTILLICIDPQLHTPMYFLLSQLSLMDLMHVSTIILKMATNYLSGKKSISFVGCATQHFLYLCLGGAECFLLAVMSYDRYVAICHPLRYAVLMNKKVGLMMAVMSWLGASVNSLIHMAILMHFPFCGPRKVYHFYCEFPAVVKLVCGDITVYETTVYISSILLLLPIFLISTSYVFILQSVIQMRSSGSKRNAFATCGSHLTVVSLWFGACIFSYMRPRSQCTLLQNKVGSVFYSIITPTLNSLIYTLRNKDVAKALRRVLRRDVITQCIQRLQLWLPRV | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 36588
Sequence Length: 323
Subcellular Location: Cell membrane
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Q9H205 | MELWNFTLGSGFILVGILNDSGSPELLCATITILYLLALISNGLLLLAITMEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGGAEDLLLAFMAYDRYVAICHPLTYMTLMSSRACWLMVATSWILASLSALIYTVYTMHYPFCRAQEIRHLLCEIPHLLKVACADTSRYELMVYVMGVTFLIPSLAAILASYTQILLTVLHMPSNEGRKKALVTCSSHLTVVGMFYGAATFMYVLPSSFHSTRQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVLGKYMLPAHSTL | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35270
Sequence Length: 316
Subcellular Location: Cell membrane
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A6NM03 | MELRNSTLGSGFILVGILNDSGSPELLYATFTILYMLALTSNGLLLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMFLALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHTMYTMHLPFCVSWEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASYTLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFHSPKQDNIISVFYTIVTPALNPLIYSLRNKEVMRALRRVLGKYILLAHSTL | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35270
Sequence Length: 316
Subcellular Location: Cell membrane
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Q8NGZ0 | MGHQNHTFSSDFILLGLFSSSPTSVVFFLVLFVIFIMSVTENTLMILLIRSDSRLHTPMYFLLSHLSLMDILHVSNIVPKMVTNFLSGSRTISFAGCGFQVFLSLTLLGGECLLLAAMSCDRYVAICHPLRYPILMKEYASALMAGGSWLIGVFNSTVHTAYALQFPFCGSRAIDHFFCEVPAMLKLSCADTTRYERGVCVSAVIFLLIPFSLISASYGQIILTVLQMKSSEARKKSFSTCSFHMIVVTMYYGPFIFTYMRPKSYHTPGQDKFLAIFYTILTPTLNPFIYSFRNKDVLAVMKNMLKSNFLHKKMNRKIPECVFCLFLC | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37063
Sequence Length: 328
Subcellular Location: Cell membrane
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Q8NG84 | MNISDVISFDILVSAMKTGNQSFGTDFLLVGLFQYGWINSLLFVVIATLFTVALTGNIMLIHLIRLNTRLHTPMYFLLSQLSIVDLMYISTTVPKMAVSFLSQSKTIRFLGCEIQTYVFLALGGTEALLLGFMSYDRYVAICHPLHYPMLMSKKICCLMVACAWASGSINAFIHTLYVFQLPFCRSRLINHFFCEVPALLSLVCQDTSQYEYTVLLSGLIILLLPFLAILASYARVLIVVFQMSSGKGQAKAVSTCSSHLIVASLFYATTLFTYTRPHSLRSPSRDKAVAVFYTIVTPLLNPFIYSLRNKEVTGAVRRLLGYWICCRKYDFRSLY | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 37763
Sequence Length: 335
Subcellular Location: Cell membrane
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Q8NGE2 | MKNKTVLTEFILLGLTDVPELQVAVFTFLFLAYLLSILGNLTILILTLLDSHLQTPMYFFLRNFSFLEISFTNIFIPRVLISITTGNKSISFAGCFTQYFFAMFLGATEFYLLAAMSYDRYVAICKPLHYTTIMSSRICIQLIFCSWLGGLMAIIPTITLMSQQDFCASNRLNHYFCDYEPLLELSCSDTSLIEKVVFLVASVTLVVTLVLVILSYAFIIKTILKLPSAQQRTKAFSTCSSHMIVISLSYGSCMFMYINPSAKEGDTFNKGVALLITSVAPLLNPFIYTLRNQQVKQPFKDMVKKLLNL | Function: Odorant receptor.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 34902
Sequence Length: 309
Subcellular Location: Cell membrane
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A6NND4 | MDATACNESVDGSPVFYLLGIPSLPETFFLPVFFIFLLFYLLILMGNALILVAVVAEPSLHKPMYFFLINLSTLDILFTTTTVPKMLSLFLLGDRFLSFSSCLLQMYLFQSFTCSEAFILVVMAYDRYVAICHPLHYPVLMNPQTNATLAASAWLTALLLPIPAVVRTSQMAYNSIAYIYHCFCDHLAVVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYVHILASVLRISSLEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIMGNVVYAILTPILNPLIYTLRNRDVKAAITKIMSQDPGCDRSI | Function: Olfactory receptor . Activated by the synthetic sandalwood odorant sandalore . Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs . Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes . Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases .
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 35503
Sequence Length: 320
Subcellular Location: Cell membrane
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P58651 | MNEAVLLGEGFTLMFLGMGFVLSFLFLLIFAIRGMSAVITRFFPEPVAAPAPRAVPVVDDFTRLKPVIAAAIHHHRHHV | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 8726
Sequence Length: 79
Subcellular Location: Cell membrane
EC: 7.2.4.2
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Q9KUH2 | MTHIGSLLLDAATLMVTGMAVVFLFLTLLVYLVQFMSRVIPQEVPEAAATPKKSQKVQPVTDSVSPQVVAAIAAAVHQHRSATAKQ | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9170
Sequence Length: 86
Subcellular Location: Cell membrane
EC: 7.2.4.2
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Q03032 | MTNAALLLGEGFTLMFLGMGFVLAFLFLLIFAIRGMSAAVNRFFPEPAPAPKAAPAAAAPVVDDFTRLKPVIAAAIHHHHRLNA | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 8956
Sequence Length: 84
Subcellular Location: Cell membrane
EC: 7.2.4.2
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Q9KTU4 | MQSTSLFLEGINLLTLGMGFVFIFLIFLVYATRAMSQLIVRFAPPEVPAKTTNKKASANKAKANPNQNQGELLAVLTAAVHHHKTQQKLS | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9867
Sequence Length: 90
Subcellular Location: Cell membrane
EC: 7.2.4.2
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P58650 | MNSSVLLGEGFTLMFLGMGFVLAFLFLLIFAIRGMSAAVNRFFPEPVPVPKAAPAAAPADDFARLKPVIAAAIHHHRRLNP | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 8745
Sequence Length: 81
Subcellular Location: Cell membrane
EC: 7.2.4.2
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B7LVP2 | MNAAQLLGEGFTLMFLGMGFVLGFLCLLILAIKSMSVAVNRFFPEPVAAPKPAATTAAPADDFSRLKPVIAAAIHHHRRLNS | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 8763
Sequence Length: 82
Subcellular Location: Cell membrane
EC: 7.2.4.2
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Q9RFA0 | MTNAELFGEGINLMIAGMGFVMFFLIILIYAISVISRLINKYFPDPTQTPPAQPIPAVIPPTDLERLRPVIVAAIAHHRRQQRSN | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 9513
Sequence Length: 85
Subcellular Location: Cell membrane
EC: 7.2.4.2
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P13155 | MTDNAVLLGEGFTLMCLGMGFVLVFLLLLIFAIRGMSLAVNRLFPEPPAAPKPAPAAVAPADDFARLKPAIVAAIHHHRRLHP | Function: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
Catalytic Activity: H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate
Location Topology: Single-pass membrane protein
Sequence Mass (Da): 8909
Sequence Length: 83
Subcellular Location: Cell membrane
EC: 7.2.4.2
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Q18040 | MLSSLRRVVPSLPRGSRSLTSQQIFDREKKFGCHNYKPLPVALSKGEGCFVWDVEGKKYFDFLAAYSAVNQGHCHPKLLKVVQEQASTLTLTSRAFYNNVLGEYEEYVTKLFKYDKVLPMNTGVEACESAVKLARRWAYDVKGVKDNEAVVVFAENNFWGRSIAAISASTDPDSFARFGPFVPGFKTVPYNNLKAVEDAIKDKNVAAFMVEPIQGEAGVVLPDPGYLKGVSDLCKKYNVLFITDEVQSGLGRSGKLLAHYHDNVRPDIVVLGKALSGGFYPVSAVLCDDNVMMNIKPGEHGSTYGGNPLACKVAIAALEILQEEKLVENSAVMGDLLMSKLKTLPKDIVSTVRGKGLFCAIVINKKYDAWKVCLKLKENGLLAKNTHGDIIRFAPPLCINKEQVEQAADIIIKTVTDFAKQN | Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 46454
Sequence Length: 422
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
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Q54JP5 | MDPISSQIQECTSKELIEMESEFAAHTYHPIPVVFKKASGVHVWDVEEKQYFDFLSAYSAVNQGHSHPKIVSALITQAQKCALSSRAFYNEVFPQYAKYITEYFGYEMVLPMNTGAEAVETSIKLARRWGYVKKGIAEDQAIVISCKGCFHGRTIGVISMSDDPSSYNKYGPLMNGIIKIDYNSTQQLEEVLSQHADRVCGFIVEPIQGEAGVVVPDEGYLKKCYELCKKYNVLLVADEIQTGLCRTGRMLCSDWDGIKPDLVLLGKAISGGLLPISAVLGGKDVMLTIKPGEHGSTYGGSPLASAVAMAALDVLRDENLAENAQKLGEHFRAQISNINHPAIQLVRGKGLLNAIVIDPNFTVSAWDICIKFAENGLLAKPTHDNIIRLAPPLTITLEQIDQCVSIIKKVFDSFKN | Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 45752
Sequence Length: 416
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Cytoplasm
EC: 2.6.1.13
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Q9VW26 | MFAKLSARGIATRMSFLAQKTASQETTAAAGSRSELVYARENKYGAHNYHPLPVALTKGEGVFVWDVEGKRYFDYLSAYSAVNQGHCHPKIVAALTAQASKLALTSRAFYSDVLGEYEEYVTKLFGFDKVLPMNTGVEGGETACKLARKWGYLEKKIPANQAKIIFARNNFWGRTLSAVSASNDPSSYEGFGPFMPGFELIEYDNVSALEESLKDPNVCAFMVEPIQGEAGVVVPSDGYLKKVRELCTKYNVLWIADEVQTGLARTGKLLAVDYEQVQPDILILGKALSGGMYPVSAVLCNDQVMLCIKPGEHGSTYGGNPLGCRVAMAALEVLQEEKLAENAFKMGDLLRNELSTLPKDVVSVVRGKGLLNAIVINQKFDAWEVCLRLKENGLLAKPTHGDIIRFAPPLVINETQMRESIDIIRKTILSM | Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 47312
Sequence Length: 431
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
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Q92413 | MTSNGTNGSATAYHASSTQEAIQAENDFAAHNYHPLPVVFARAQGTSVWDPEGRHYLDFLSAYSAVNQGHCHPKLVAALVDQASRLTLSSRAFYNDVFPKFAEMVTKYFGFDMVLPMNTGAEAVETGIKIARKWGYKVKGIPENEAIILSAENNFHGRTMAAISLSSDPESRENYGPYVPNIGCTIPGTEKPITYNDKAALREAFEKAGSNLAAFLVEPIQGEAGIIVPDDDYLQLARSLCDQHNVLLICDEIQTGIARTGKLLCHEWSGIKPDMVLLGKAISGGMYPVSCVLGRKDVMLTVEPGTHGSTYGGNPLACAVAIRALEVVQEENMVERAEKLGQAFRSGLEAIQNPIIQTVRGKGLLNAIVIDESKTNGHTAWDLCMLMKEKGLLAKPTHQNIIRLAPPLVITEEEIAKALEIIKAAVAELPNLKGAAEDKVVPPPEKKVKITLEN | Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 49216
Sequence Length: 454
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Cytoplasm
EC: 2.6.1.13
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C4L2E7 | MSKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPKIIQALKDQADKITLTSRAFYNDQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRWAYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGFGPLLPGFKVVPYGDIDAFEAAITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAIEWEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALEVLEEENLPERSLELGTYFMDRLKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGLLCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS | Function: Catalyzes the interconversion of ornithine to glutamate semialdehyde.
Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 43690
Sequence Length: 400
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Cytoplasm
EC: 2.6.1.13
|
P04181 | MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF | Function: Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Catalytic Activity: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde
Sequence Mass (Da): 48535
Sequence Length: 439
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
|
P29758 | MLSKLASLQTIAALRRGVHTSVASATSVATKKTEQGPPSSEYIFERESKYGAHNYHPLPVALERGKGIYMWDVEGRQYFDFLSAYGAVSQGHCHPKIIDAMKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYNKVLPMNTGVEAGETACKLARRWGYTVKGIQKYKAKIVFADGNFWGRTLSAISSSTDPTSYDGFGPFMPGFETIPYNDLPALERALQDPNVAAFMVEPIQGEAGVIVPDPGYLTGVRELCTRHQVLFIADEIQTGLARTGRWLAVDHENVRPDMVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRIAIAALEVLEEENLAENADKMGAILRKELMKLPSDVVTSVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRLAPPLVIKEDEIRESVEIINKTILSF | Function: Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Catalytic Activity: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde
Sequence Mass (Da): 48355
Sequence Length: 439
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
|
Q10G56 | MAAALARRGGGGLARALARGRGMCSATAAERAAGAALTSEELMRMERERSAHNYHPIPVVFSKGEGSHILDPEGNKYIDFLSAYSAVNQGHCHPKVLRALKEQAERLTLSSRAFYNDKFPIFAEYLTSMFGYEMMLPMNTGAEGVETAIKLVRKWGYEKKKIPKNEALIVSCCGCFHGRTLGVISMSCDNDATRGFGPLVPGHLKVDFGDTDGLEKIFKDHGERICGFLFEPIQGEAGVIIPPDGYLKAVRDLCSRHNILMIADEIQTGIARTGKMLACDWENIRPDVVILGKALGAGVVPVSAVLADKDIMLCIKPGEHGSTFGGNPLASAVAVASLKVVTDEGLVERAAKLGQEFRDQLQKVQQRFPQIIREVRGRGLLNAVDLSNEALSPASAYDICIKLKERGVLAKPTHDTIIRLAPPLSISPEELAEASKAFSDVLEHDLPQLQKQIKKTESAAEKQSCDRCGRDLY | Function: Confers drought and oxidative stress tolerance mainly through enhancing ROS-scavenging capacity and Pro pre-accumulation.
Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 51442
Sequence Length: 473
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
|
Q6LFH8 | MDFVKELKSSQDYMNNELTYGAHNYDPIPVVLKRGKGVFVYDIEDRRYYDFLSAYSSVNQGHCHPDILNAMINQAKKLTICSRAFFSDSLGVCERYLTNLFGYDKVLMMNTGAEASETAYKLCRKWGYEVKKIPENSAKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNFLKVPYDDLEALEKELQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQTGLGRTGKLLCTHHYGVKPDVILLGKALSGGHYPISAILANDDVMLVLKPGEHGSTYGGNPLAAAICVEALKVLINEKLCENADKLGAPFLQNLKEQLKDSKVVREVRGKGLLCAIEFKNDLVNVWDICLKFKENGLITRSVHDKTVRLTPPLCITKEQLDECTEIIVKTVKFFDDNL | Function: The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and, to a lesser extent, of glutamate-5-semialdehyde with glutamate and alanine.
PTM: The disulfide bond between Cys-154 and Cys-163 is reduced by TRX1 which increases OAT catalytic activity.
Catalytic Activity: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde
Sequence Mass (Da): 46055
Sequence Length: 414
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Cytoplasm
EC: 2.6.1.13
|
P04182 | MLSKLASLQTVAALRRGLRTSVASATSVATKKTEQGPPSSEYIFERESKYGAHNYHPLPVALERGKGIYMWDVEGRQYFDFLSAYGAVSQGHCHPKIIEAMKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYNKVLPMNTGVEAGETACKLARRWGYTVKGIQKYKAKIVFAVGNFWGRTLSAVSSSTDPTSYDGFGPFMPGFETIPYNDLPALERALQDPNVAAFMVEPIQGEAGVIVPDPGYLTGVRELCTRHQVLFIADEIQTGLARTGRWLAVDHENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRIAIAALEVLEEEHLAENADKMGAILRKELMKLPSDVVTAVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRLAPPLVIKEDEIRESVEIINKTILSF | Function: Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
Catalytic Activity: 2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde
Sequence Mass (Da): 48333
Sequence Length: 439
Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular Location: Mitochondrion matrix
EC: 2.6.1.13
|
A4XJS8 | MFVDIAKIYVKAGDGGDGIVAFRREKYVPAGGPAGGDGGKGGDVIFVADRELNTLLDFKYKRHYKAQNGERGGPNNMHGKDGEDLIIKVPVGTVIKDAETGEIIADLSREGDRAIVAHGGRGGRGNAHFATATRQVPRFAEVGEKGDELWVILELKVLADVGLIGYPNVGKSTFLSVATNARPEIANYPFTTKYPNLGIVYISEGESFVLADIPGLIEGASEGAGLGHQFLRHVERTKVLIHIVDVSGSEGREPVEDFIKINEELKKYSPELAQKPQIVAANKMDLPDAQAYFELFKEEIEKMGYEVYPISAATGMGIREVLKRAYELLKQQKAAENIEEDAKPRTFVYYKKKDVKPLTVRKENGVYVVEGTVVEKVARNIVLNDHDSFRYFQNFLNKLGVFDKLREMGIQDGDIVRILDVEFEYYE | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 47306
Sequence Length: 427
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
A0RR37 | MFVDSASFSVSSGKGGPGCASFRREKHVPLGGPDGGDGGNGGDVYFIVDNNTHTLANYKGKRAMKAANGVPGLPRNMTGKKGDNLELIVPPGTAVYDADSNELLLDLISEGQKELFLSGGKGGLGNVHFKTSVNQAPTKAQPGLPGETRNIRLELKLIADVGLVGFPNVGKSTLISSISNAKPQIANYEFTTLTPKLGLVEVDEFSGFIMADIPGIIEGASDGKGLGIQFLKHIERTKVLLYMIDLANYRSLKEQFETLKSEVLKFSPNLAKRDFAIALTRLDAAVDADEKIEEFLNEFKFDKKQDIYEYDRQKPFFVLPISSVAGDGLKELKFGLLEILKGEN | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 37189
Sequence Length: 344
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
Q1MQQ1 | MRFVDEVTISVSAGKGGNGCVSFRREKFIPKGGPNGGDGGDGGNIIFKADSRLLTLYDFRVQRHYRAQNGEGGKGSQRHGKKGEDLILHLPVGTIIFEQLLDKEYFLVDLDRPGVEFLIARGGRGGKGNEHFKSSTMRTPRFAQKGEMGEEKYLRLELKILADAGIIGLPNAGKSTLISKLSAAQPKIAAYPFTTLNPNLGVMIDNLDPDKRLVLADIPGLIEGACKGQGLGHQFLKHIERTRFLIHVLSSEDIDEDNPWLGFDIVNEELKEFDHTLMQRTQLLVVNKIDVLQPEKLSHIKQVAESSGKIIYFISAETGEGIELLVDAIWKLQSYRLNAPFIHLKPIEHKSDEEFAIEVAYTKE | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 40445
Sequence Length: 364
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
Q7TUR3 | MQFIDQARITVRAGRGGDGIMAFRREKYVPAGGPSGGDGGNGGNVVLEADGNLQTLLDFKYKRLFPAPDGRRGGPNRCTGASGKDLIIKVPCGTEVRHLYTGILLGDLTRSEDLLVVAFGGRGGLGNAHYLSNRNRAPEKFTEGRDGEEWFLQLELKLLAEVGIIGLPNAGKSTLISVLSAARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRLLIHVLDGGAEDPVEDLLVVEKELVAYGHDLVERPRLLVLNKQELLDEQHQDQLVDALQAASGRSLILISAAMGLGLEGLLAQVWKELGV | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 35158
Sequence Length: 329
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
Q46HF4 | MQFIDQAIIDVKAGSGGDGISAFRREKYVPAGGPAGGDGGQGGNVVLEADDNLQTLLDFKFQKLISAENGQRGGPNKCTGASGKDTVLKVPCGTEVRHLSTNIILGDLTNKGQQLIVAFGGKGGFGNARYLSNSNRAPEKFTEGKVGEEWSLQLELKLLAEVGIIGLPNAGKSTLISVLSSARPKIADYPFTTLIPNLGVVRRPSGDGTVFADIPGLISGASKGIGLGHDFLRHIERTKVLLHLIDSASTDPINDFKTINEELTSYGHGLISRPRIFVLNKKELLNENEIKKLLNKIEKMTMKKVHIISAVTKFGLDDLLSSIWNELGY | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 35291
Sequence Length: 329
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
A8F478 | MQKEDFVDRVTIFVKAGDGGNGAVSFRREKYVPKGGPDGGDGGDGGFVILRANPGLSTLLNFKYQRRFIAQNGQHGKGKKQSGKSGEDLVIDVPVGTIVKDANTGEVLADLDRSWMMVCVARGGKGGRGNIHFATSVFRAPRIAEKGDKGEERWLELELKLLADAGLIGFPNVGKSSLISAMSNARPKIADYPFTTLVPNLGVVKIDENSEFVLADIPGLIERASEGAGLGNLFLRHIERCSVLVHVIDISGSEGRDFIKDYDVIVQELCKYNEQLSRKPQIIVANKIDLLEKDELEKRLETLEKHANQKIYPVSALLRINIDILKQKIFEIVGKSRLLLQKQPVPVFEKPKPIRTKIEERFDFEIKKTQDGFEICGEQIDKWLSRYSLEQKDALERFLDTLERNGLSEKLKQMGAHDGDTVWIGQYSFEYKE | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 48390
Sequence Length: 433
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
Q9PAS3 | MKFVDEAEIQVIAGNGGDGCVSFRREKFIPLGGPDGGDGGDGGSVWLVADENLNTLVDFRHERIFKAQRGVNGMGQQMYGKAGQDKIISVPIGTVVINVQTDEVIGDMVRHGDRLLVAKGGTGGLGNMHFKSSINRAPRQARPGEQGEERTLKLELKLLADIGMLGFPNVGKSTFIRAVSAATPKVADYPFTTLYPNLGVVKIEAYSSFVIADVPGLIEGAADGVGLGTQFLRHLQRTKLLLHMVDISATADAYGNEKVGVGLLPIEQVRKLEIELERHDPALLDKPRWLVLNKADLMPQEEAQALAEALIAELHWTAPWYLVSAVSREGTWPIMKSAMTLFEHQREVAAEQSVSSR | Function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Sequence Mass (Da): 38774
Sequence Length: 357
Subcellular Location: Cytoplasm
EC: 3.6.5.-
|
P72296 | MPFDPLFLWETFIALLAGIPLALKLAVFSIAVGTVLAFSLALMRVSRRWWLDFPARFYIFAFRGTPLLVQIYIIYYGLSQFPGLRHSLLWPFLREAYWCALGALALNTAAYSAEIMRGGLLSVPAGQIEAARACGMARVLLFRRIIIPQAIRQMLPGYSNEVVLMVKSTSLASTITLMEITGIAAKLISETYRPVEVFACAGAIYLTMNFIAARLFALIEWSLWPERRKTRRPVDLADQKGELHV | Function: Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 27536
Sequence Length: 245
Subcellular Location: Cell inner membrane
|
P35114 | MPFDPAFLWQTFVALLSGIPLALQLAVFSVALGTVLAFGLALMRVSRLWWLDLPARFYIFAFRGTPLLVQIYIIYYGLSQFPDVRHSFIWPFLRDAYWCAMAALALNTAAYTAEIMRGGLLSVPAGQIEAAKACGMGRVKLFRRIVIPQAIRQMLPGYSNEVILMVKSTSLASTITIMEITGIAAKLISESYRTVEVFSCAGAIYLILNFIVARLFTLLEWALWPERRNNRLTTDPVDRKGELHA | Function: Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 27487
Sequence Length: 245
Subcellular Location: Cell inner membrane
|
P0A2V2 | MPNPVRPAVQLKDIRKNFGNLEVLHGVSLSANEGEVISILGSSGSGKSTLLRCVNMLEVPNAGSVAIMGEEIALEHRAGRLARPKDLKQVNRLRERAAMVFQGFNLWSHQTILQNVMEAPVHVQGRDRKACRDEAEALLERVGIASKRDAYPSELSGGQQQRAAIARALAMRPDVMLFDEPTSALDPELVGEVLKVMRDLAAEGRTMLIVTHEMDFARDVSSRTVFLHQGVIAEEGPSSEMFAHPRTDRFRQFLRRDGGTSH | Function: Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
Location Topology: Peripheral membrane protein
Sequence Mass (Da): 28954
Sequence Length: 262
Subcellular Location: Cell inner membrane
|
P0A4N5 | MDYSQLMGFGPDGWGYDMLRATAMTMAVAFSGFTIGLVFGCLGAAASLSSSGALQAAASGYTTALRGIPDLLVIYLFYFGSSSVISNVASLFGSSGFVGASTFLIGALAIGVVSGAYQTQVLRGAVLALNKGEIEAGRAYGMGALLLFRRIVLPQAARYALPGVGNVWQLVLKESALISVIGLVELMRQAQVGSGSTRQPFSFYLTAAALYLLITFVSGQVFRLAETRSMRGLQRGV | Function: Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
Location Topology: Multi-pass membrane protein
Sequence Mass (Da): 24801
Sequence Length: 237
Subcellular Location: Cell inner membrane
|
Q9BHM6 | MTVKVCVCGGGNGAHTLSGLAASRDGVEVRVLTLFADEAERWTKALGADELTVIVNEKDGTQTEVKSRPKVITKDPEIAISGADVVILTVPAFAHEGYFQAMAPYVQDSALIVGLPSQAGFEFQCRDILGDKAAAVSMMSFETLPWACRIKEFGRKVEVLGTKSVLAASLIKGTAKTVDPLSTLQMLHGAEPVFRLAKHFLEMLIMSYSFVHPAILFGRWGSWDGKPVPEAPLFYQGIDQATADMLTACSNECKDVANAIMAACPGNDLSDVKDIYQWYLEYYHEDIQDDHDLYHAITTNKSYKGLVHPVKAVDGGVAPDFGNRYLTEDIPMGMIVFKGVAIAAGVAIPSNDKLIMWAQEKIGKEYLVDGALTGKDVATTRCPQRYGFNTLDAILTGKK | Function: Catalyzes the reverse reaction of octopine dehydrogenation. Acts on L-arginine in preference to other substrates such as canavanine, cysteine, L-alanine, ornithine or norvaline, owing to the presence of the positively charged guanidium group.
Catalytic Activity: D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate
Sequence Mass (Da): 43320
Sequence Length: 399
EC: 1.5.1.11
|
Q6Z244 | MVAPSRLPSHEEQSAAAAADGSATPSQGIPVVDLGVLINGAADERSRAIRDLGRACEDWGFFMVTNHGVPEALREAIMDACKELFRLPLEEKKEYMRAKPMDPIRIGTGFYSVVDAVPCRRDYLKMFSHPEFHCPEKPAKLREIATEYATCTRALLLELTKAISESLGLAGGRLSEALNLESCFQILVGNHYPACSRPDEQAMGLSAHSDHGLLTLLFQNGVDGLQVKHDGEWLLAKPLPGSFFVIAGDQLEIVTNGRYKGVLHRAVVGGEQSRMSFVSLIGPCMDTVVEPLPEMAADGRGLEFRGIRYRDYMEMQQSNSINEKTALDIVRVMHQAG | Cofactor: Binds 1 Fe(2+) ion per subunit.
Function: Involved in melatonin degradation . Catalyzes the hydroxylation of melatonin to produce 2-hydroxymelatonin .
Catalytic Activity: 2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate
Sequence Mass (Da): 36999
Sequence Length: 337
Subcellular Location: Cytoplasm
EC: 1.14.11.-
|
Q7XR83 | MPAVAGSLYMASQHKGVPPPLPPPPRPLPVINLGRLTMDSASRALAVRDIVLACRERGCFEVVNHGISRSCMNGALEAASEFFQLSTERKEEFASDDIRQPIRYDTSSRDGISMSRSFLKHYANPLDDWIKFWPTQPPTYREKMGEYAVETQRVSMQLMEAILQGLGLGPSYLQEKLEGGVQFVALNNYPQSSAKKADKIGLAPHSDYGFLTILLQSSPGLEVMHHEDDAWTSVPAIPGALHVHVGDHLEVLSNGQLKSLVHRAVLNPNESRISIASIHGLSMDEEVHCAEELVDEHHPKMYRGSSFQDFLDFLPANMNRYKRYVESLRIDKP | Cofactor: Binds 1 Fe(2+) ion per subunit.
Function: Involved in melatonin degradation . Catalyzes the hydroxylation of melatonin to produce 2-hydroxymelatonin .
Catalytic Activity: 2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate
Sequence Mass (Da): 37187
Sequence Length: 333
Subcellular Location: Plastid
EC: 1.14.11.-
|
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