recall
int64 0
1
| article_title
stringlengths 5
500
| topic
stringlengths 21
84
| abstract
stringlengths 2
65.8k
|
|---|---|---|---|
0 |
A comparison of the transtibial pullout technique and all-inside meniscal repair in medial meniscus posterior root tear: Prognostic factors and midterm clinical outcomes
|
Osteochondritis Dissecans 2020 Review
|
INTRODUCTION: There is a paucity of comparative clinical data between arthroscopic all-inside end-to-end meniscal root suture and transtibial pullout technique in medial meniscus posterior root tears (MMPRT). Therefore, this study aimed to compare treatment failure, mid-term clinical and radiological outcomes of all-inside meniscus root repair versus the transtibial pullout technique and to analyze prognostic factors of postoperative clinical and radiological outcomes. MATERIAL AND METHODS: Forty-four patients were included in two therapeutic group: arthroscopic all-inside meniscal suture (MS: 13 knees) and transtibial pullout technique (TP: 31 knees).Primary clinical outcomes at a minimum of 27.2 months postoperatively included Knee injury and Osteoarthritis Outcome Score (KOOS) and Lysholm Knee Questionnare (LKQ). Radiographic assessment of the knee was performed to determine osteoarthritis severity using the Kellgren-Lawrence (KL) grading system.In addition, pre and postoperative MRI scans and intraoperative arthroscopic findings were recorded and the correlations between these findings, as outcome predictors and postoperative patients reported subjective outcome were assessed. RESULTS: No significant differences in postoperative KOOS and LKQ scores were found between the MS and TP group (p = 0.38 and 0.17, respectively).During follow-up one patients (7.7%) in the MS group and two (6.5%) in the TP group underwent total knee arthroplasty. The difference did not reach the statistical significance (p = 0.88).No differences were observed in postoperative MRI findings such as meniscal extrusion, osteochondral defect, chondromalacia patella, and bone morrow edema (p = 0.25, 0.97, 0.97, and 0.88, respectively).A univariate model revealed that the presence of postoperative meniscal extrusion; osteochondral defect; chondromalacia patella; increased BMI; age (>40 years) and longer time lapse between clinical onset to surgery (>6 months) were predictors of poor clinical outcome. The presence of meniscal extrusion, osteochondral defect and chondropatia patella portended worst postoperative outcomes in a multiple linear regression model. CONCLUSIONS: It can be concluded that both techniques can reach good results when performed properly and if the injury pattern allows meniscal suture may be considered a treatment option for the management of MMPRT in well-selected patients.Patients with increased BMI, preoperative meniscal extrusion, chondromalacia patella, and osteochondral defect were at higher risk of poor clinical outcomes.
|
0 |
Effects of Comprehensive Care for Knee OA
|
OAK 3 - Non-arthroplasty tx of OAK
|
Anticipating trends toward generalism in medicine, the rheumatology community has begun to set forth guidelines for managing osteoarthritis (OA). These guidelines emphasize a comprehensive approach toward nondrug treatment (e.g., patient education, exercise, social support) and a conservative approach to drug management to minimize the side effects of nonsteroidal antiâ?inflammatory drugs (NSAIDs). Unfortunately, few primary care physicians provide conservative, comprehensive care for OA as promoted in the recent rheumatology literature. Also, although researchers have studied individual elements of a comprehensive approach to OA care and largely validated them in isolation, no research support exists to suggest that uniformly adopting OA care guidelines will result in better patient outcomes and/or reduced costs of care. In this project, we will implement, in a controlled fashion, and evaluate a comprehensive plan for treating patients with knee OA by primary care physicians in a managed care environment. Comprehensive care for knee OA will be guided by a procedure designed to introduce and reinforce (a) an array of nondrug, selfâ?care procedures intended to combat joint pain and preserve function and (b) a stepped protocol for drug management of knee pain that minimizes the risk of adverse side effects of NSAIDs. Participants will be 300 patients with a confirmed clinical diagnosis of knee OA who receive their medical care in a large health maintenance organization (HMO) in Indianapolis, Indiana. We will randomly allocate geographically discrete offices of the HMOs to experimental (OA care by algorithm) or control (routine OA care) conditions (150 subjects/group). Patients who enroll in the study at each location will receive care for knee OA for 1 year under the guidelines specified by random assignment. We will measure outcomes at baseline and 3 months, 6 months, and 12 months after enrollment, and outcomes will include joint pain, physical function, drug side effects, quality of life (i.e., general health status), satisfaction with OA care, and direct costs of medical care. We think that comprehensive care, as guided by our algorithms, will result in significant improvement in knee pain, physical function, and patient satisfaction, and lower direct costs compared to care delivered under routine circumstances.
|
1 |
Developmental dysplasia of the hip: nursing implications and anticipatory guidance for parents
|
Developmental Dysplasia of the Hip CPG
|
Developmental dysplasia of the hip (DDH) is a comprehensive term used to describe an abnormal relationship between the femoral head and the acetabulum. Developmental dysplasia of the hip includes a very wide spectrum of abnormality from a frank dislocation (very unstable) to a stable hip with a slightly shallow acetabulum. As many of these findings may not be present at birth, the term developmental more accurately reflects the biologic features than does the term congenital. Despite the recent increased awareness of DDH and the importance of thorough screening programs, hip dysplasia continues to be a frequently missed diagnosis in pediatrics. Earlier detection and diagnosis of DDH is associated with a much more successful and less invasive outcome
|
0 |
Asian ethnicity and the prevalence of metabolic syndrome in the osteoarthritic total knee arthroplasty population
|
Surgical Management of Osteoarthritis of the Knee CPG
|
Metabolic syndrome (MS) is a known risk factor for the development of osteoarthritis (OA). We asked whether the prevalence of MS varies across ethnicity among patients who undergo total knee arthroplasty for end-stage OA. In our population of 1460 patients undergoing primary knee arthroplasty, MS was defined as body mass index greater than 30 kg/m(2), diabetes, hypertension, and hypercholesterolemia. Among the 1334 white patients, 114 (8.5%) had MS as compared with 3 of 36 (8.3%) blacks and 18 of 90 (20%) Asians (P = .006) Adjusted analysis showed that those of Asian ethnicity had a 2.0 (95% confidence interval, 1.1-3.8; P = .03) times greater odds of MS as compared with those of other ethnicity. Metabolic syndrome is a risk factor for OA, and Asians demonstrate a greater prevalence of MS as compared with whites and blacks in this population
|
1 |
Do Outcomes of Osteochondral Allograft Transplantation Differ Based on Age and Sex? A Comparative Matched Group Analysis
|
AMP (Acute Meniscal Pathology)
|
BACKGROUND: The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed.
PURPOSE: To determine clinical outcomes for male and female patients aged >=40 years undergoing OCA compared with a group of patients aged <40 years.
STUDY DESIGN: Cohort study; Level of evidence, 3.
METHODS: A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted. The reoperation rate, failure rate, and patient-reported outcome scores were reviewed. All outcomes were compared between patients aged <40 or >=40 years, with subgroup analyses conducted based on patient sex. Failure was defined as revision OCA, conversion to knee arthroplasty, or gross appearance of graft failure at second-look arthroscopic surgery. Descriptive statistics, Fisher exact or chi-square testing, and Mann-Whitney U testing were performed, with P < .05 set as significant.
RESULTS: A total of 170 patients (of 212 eligible patients; 80.2% follow-up) who underwent OCA with a mean follow-up of 5.0 +/- 2.7 years (range, 2.0-15.1 years) were included, with 115 patients aged <40 years (mean age, 27.6 +/- 7.3 years; 58 male, 57 female) and 55 patients aged >=40 years (mean age, 44.9 +/- 4.0 years; 33 male, 22 female). There were no differences in the number of pre-OCA procedures between the groups ( P = .085). There were no differences in the reoperation rate (<40 years: 38%; >=40 years: 36%; P = .867), time to reoperation (<40 years: 2.12 +/- 1.90 years; >=40 years: 3.43 +/- 3.43 years; P = .126), or failure rate (<40 years: 13%; >=40 years: 16%; P = .639) between the older and younger groups. Patients in both groups demonstrated significant improvement in Lysholm (both: P < .001), International Knee Documentation Committee (IKDC) (both: P < .001), Knee Injury and Osteoarthritis Outcome Score (KOOS) (both: P < .001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (both: P < .001), and Short Form-12 (SF-12) physical (both: P < .001) scores compared with preoperative values. Patients aged >=40 years demonstrated significantly higher KOOS symptom ( P = .015) subscores compared with patients aged <40 years. There were no significant differences in the number of complications, outcome scores, or time to failure between the sexes. In patients aged <40 years, female patients experienced failure significantly more quickly than male patients ( P = .039). In contrast, in patients aged >=40 years, male patients experienced failure significantly more quickly than female patients ( P = .046).
CONCLUSION: This study provides evidence that OCA is a safe and reliable treatment option for osteochondral defects in patients aged >=40 years. Male and female patients had similar outcomes. Patients aged <40 years demonstrated lower KOOS symptom subscores postoperatively compared with older patients, potentially attributable to higher expectations of return to function postoperatively as compared with older patients.
|
0 |
Mirror therapy, graded motor imagery and virtual illusion for the management of chronic pain
|
SR for PM on OA of All Extremities
|
This is the protocol for a review and there is no abstract. The objectives are as follows:To examine the efficacy of mirror therapy, graded motor imagery, and virtual illusion for improving pain and function levels in chronic pain states, including, but not limited to, chronic regional pain syndrome, phantom limb pain and brachial plexus avulsion injury
|
0 |
Immunohistochemical and other features of breast carcinomas presenting clinically compared with those detected by cancer screening
|
MSTS 2018 - Femur Mets and MM
|
Features of 111 mammary carcinomas derived from breast cancer screening were compared with those of 69 carcinomas presenting 'clinically'. Screen detected cancers were smaller, had less likelihood of nodal metastases, included a higher proportion of in situ tumours and if invasive, tended to be of lower grade. Using immunohistochemical methods, the expression of c-erbB-2 oncoprotein, epidermal growth factor receptor (EGFR) and cathepsin D were compared in the two groups. A similar proportion of screened and unscreened tumours expressed c-erbB-2 oncoprotein and EGFR but expression of the oestrogen regulated protein cathepsin D was significantly more frequent in the screened group (P less than 0.05). Although a relatively small series, the results suggest a biological difference between 'screened' and 'clinical' tumours.
|
0 |
Is a short arm cast appropriate for stable distal radius fractures in patients older than 55 years? A randomized prospective multicentre study
|
Distal Radius Fractures
|
We conducted a prospective randomized, multicentre study to compare short arm and long arm plaster casts for the treatment of stable distal radius fracture in patients older than 55 years. We randomly assigned patients over the age of 55 years who had stable distal radius fracture to either a short arm or long arm plaster cast at the first review 1 week after their injury. Radiographic and clinical follow-up was conducted at 1, 3, 5, 12 and 24 weeks following their injury. Also, degree of disability caused by each cast immobilization was evaluated at the patient's visit to remove the cast. There were no significant differences in radiological parameters between the groups except for volar tilt. Despite these differences in volar tilt, neither functional status as measured by the Disabilities of the Arm, Shoulder and Hand, nor visual analogue scale was significantly different between the groups. However, the mean score of disability caused by plaster cast immobilization and the incidence rate of shoulder pain were significantly higher in patients who had a long plaster cast. Our findings suggest that a short arm cast is as effective as a long arm cast for stable distal radius fractures in the elderly. Furthermore, it is more comfortable and introduces less restriction on daily activities.
Level of evidence: Ii.
|
0 |
Definition of ideal configuration for femoral neck screw fixation in older people
|
Hip Fx in the Elderly 2019
|
Femoral neck fractures are the most common injuries encountered by older individuals, and they are associated with high mortality and morbidity. Internal fixation to femoral neck fracture with cannulated screws placed with a configuration of an inverted triangle remain a feasible and effective treatment for femoral neck fractures. The objection of this research was to evaluate the femoral neck morphology, especially the shape of the femoral neck in Chinese people to find the optimal screw position and interval between the screws. 96 consecutive normal subjects without any previous proximal femur operation were reviewed. The patients' information were collected from our database. The minimum of neck canal height (NCHM), neck canal width (NCWM) and inclination angle (AIA and PIA) were measured in different level. There was a significant difference between the AIA and PIA, neck canal height at inferior and superior 1/3 on posterior wall (NCHIP and NCHSP). Although there was a significant difference between the neck canal height at inferior and superior 1/3 on anterior wall (NCHIA and NCHSA, p < 0.001), but the changes were small. The shape of the anterior wall was perpendicular to the horizon and almost parallel with the FNA. In contrast, the shape of the posterior wall resembled a reverse question mark. The inverse triangular fixation was in accordance with the morphology of the femoral neck, and triangular fixation had a high risk of perforation, which may lead to nonunion and avascular necrosis. The anterior screw can be inserted easily with the help of a C-ARM, and the posterior screw positioned mildly posterior to the femoral shaft axis is recommended.
|
1 |
Population-based, inception cohort study of the incidence, course, and prognosis of mild traumatic brain injury after motor vehicle collisions
|
DoD PRF (Psychosocial RF)
|
Objective To determine the incidence, course, and prognosis of adult mild traumatic brain injury (MTBI) caused by motor vehicle collisions. Design Prospective, population-based, inception cohort study. Setting The province of Saskatchewan, Canada, with a population of about 1,000,000 inhabitants. Participants All adults (N=1716) incurring an MTBI in a motor vehicle collision between November 1997 and December 1999 in Saskatchewan. Interventions Not applicable. Main Outcome Measures Age- and sex-stratified incidence rates, time to self-reported recovery, and prognostic factors over a 1-year follow-up. Results Of 7170 adults injured in a motor vehicle collision over the 2-year inception period, 1716 (24%) met our cohort definition of MTBI. There were more women affected (53%), and MTBI was most common in the 18- to 23-year-old group. Most were not hospitalized (73%), but 28% reported loss of consciousness and 23% reported posttraumatic amnesia. The annual incidence of MTBI per 100,000 adults was 106.1 (95% confidence interval [CI], 98.9-113.6) in the first year and 118.3 (95% CI, 110.8-126.3) in the second year of the study. The 1-year follow-up rate was 84%. The median time to recovery was 100 days (95% CI, 97-103), and about 23% reported not having recovered by 1 year. Factors associated with delayed recovery included being older than 50 years, having less than a high school education, having poor expectations for recovery, having depressive symptoms, having arm numbness, having hearing problems, having headaches, having low back pain, and having thoracic back pain. Loss of consciousness and posttraumatic amnesia were not associated with recovery. Conclusions MTBI affects almost a quarter of persons reporting an injury after a traffic collision. The median time to recovery is 100 days, but 23% have still not recovered by 1 year. A mix of biopsychosocial factors is associated with recovery, including a strong effect of poor expectations for recovery. © 2014 by the American Congress of Rehabilitation Medicine.
|
1 |
Extramedullary fixation of 107 subtrochanteric fractures: a randomized multicenter trial of the Medoff sliding plate versus 3 other screw-plate systems
|
Management of Hip Fractures in the Elderly
|
We compared the efficacy of a load-sharing device, the Medoff sliding plate (MSP), with that of 3 other load-bearing screw-plate devices for the fixation of subtrochanteric fractures in a randomized multicenter trial of 107 elderly patients. 55 fractures were operated on with the MSP, and 52 with the dynamic hip screw (DHS) with or without a trochanteric stabilizing plate (TSP) or with the dynamic condylar screw (DCS). The patient material in the groups was similar regarding age, domestic situation, preinjury walking ability and fracture types. We followed the patients clinically and radiographically for a minimum of 1 year. There was no significant difference in walking ability or return rate to the home at follow-up. Fixation failure occurred in 1/55 fractures operated on with the MSP, in 3/32 with the DHS, in 3/12 with the DCS and in 2/8 with the DHS/TSR The difference in the rate of fixation failure was statistically significant, when the MSP group was compared to the 3 load-bearing devices in the other group (1 vs 8). On the basis of this experience, we think that the load-sharing principle of the MSP, which seems to facilitate fracture impaction and stability, appears to be a good alternative in extramedullary fixation of subtrochanteric fractures
|
0 |
Characteristics of clinical measurements between biomechanical responders and non-responders to a shoe designed for knee osteoarthritis
|
OAK 3 - Non-arthroplasty tx of OAK
|
PURPOSE: The purpose of this study was to investigate the characteristics of biomechanical and clinical measurements in relation to the knee adduction moment when wearing a standard shoe and a shoe design for individuals with knee osteoarthritis (Flex-OA).
METHODS: Kinematic and kinetic data were collected from thirty-two healthy individuals (64 knees) using a ten camera motion analysis system and four force plates. Subjects performed 5 walking trials under the two conditions and the magnitude of individuals' biomechanical responses where explored in relation to the clinical assessment of the Foot Posture Index, hip rotation range, strength of hip rotators, and active ankle-foot motion, all of which have been described as possible compensation mechanisms in knee osteoarthritis.
RESULTS: Significant reductions in the first peak of the knee adduction moment (KAM) during stance phase (9.3%) were recorded (p<0.0001). However, despite this difference, 22 of 64 knees showed either no change or an increased KAM, indicating a non-response or negative-response to the Flex-OA shoe. Significant differences were observed between the responder and non-responder subgroups in the hip rotation range ratio (p=0.044) and the hip rotators strength ratio (p=0.028).
CONCLUSION: Significant differences were seen in clinical assessments of hip rotation range and hip rotator strength between responders and non-responders using a cut-off of 0.02Nm/kg change in the KAM.
|
0 |
3-Tesla Magnetic Resonance Imaging Evaluation of Posterior Tibial Tendon Dysfunction with Relevance to Clinical Staging
|
PRP (Platelet-Rich Plasma)
|
The posterior tibial tendon (PTT) is the most important dynamic stabilizer of the medial ankle and longitudinal arch of the foot. PTT dysfunction is a degenerative disorder of the tendon, which secondarily involves multiple ligaments, joint capsules, fascia, articulations, and bony structures of the ankle, hindfoot, midfoot, and forefoot. When the tendon progressively attenuates, the patient develops a painful, progressive collapsed flatfoot or pes planovalgus deformity. This comprehensive review illustrates the 3-Tesla magnetic resonance imaging (3T MRI) features of PTT dysfunction. In addition, the reader will gain knowledge of the expected pathologic findings on MRI, as they are related to clinical staging of PTT dysfunction. © 2011 American College of Foot and Ankle Surgeons.
|
0 |
The effectiveness of sensory re-education in idiopathic carpal tunnel syndrome
|
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
|
Purpose: The purpose of this study was to investigate the effectiveness of sensory re-education on light touch/pressure sensation and finger dexterity in Idiopathic Carpal Tunnel Syndrome (ICTS). Materials and Methods: Thirty-six subjects with ICTS were randomly separated into two groups. 18 subjects in the control group were treated with a conservative treatment method composed of hot-pack, ultrasound and exercise. 18 subjects in study group were treated with a treatment method including of hot-pack, ultrasound, exercise and sensory re-education and desentizisation. Treatment was continued 2 weeks. All subjects were assessed before and after treatment for sensory thresholds (touch-perception) and sensory function (Static Two-Point Discrimination Test, O'Connor Finger Dexterity Test). Results: When light touch/pressure sensation of control and study groups were compared, the hands of study group was seen to have recovery areas. Post treatment two-point discrimination test results in both groups were found statistically significant in favor of the study group (p< 0.05. Post treatment O'Connor Finger Dexterity Test results in both groups were found statistically significant in favor of the study group (p<0.05). Discussion: Results obtained from the study group in regards to sensation suggest that sensory reeducation will positively affect the functional use of hand. The results show that, in rehabilitation programs of patients with
|
0 |
Use of a skin-fat composite graft to prevent alar notching: an alternative to delayed postoperative repair
|
Reconstruction After Skin Cancer
|
BACKGROUND: Full-thickness defects of the alar rim can be challenging to repair and often require the use of multistaged interpolated flaps. Alar notching is a known complication of these procedures even after cartilage batten grafts have been placed to support the alar framework. Standard techniques for repair of alar notching involve reinsertion of a cartilage graft, usually at the time of alar groove reconstruction 3 months postoperatively. OBJECTIVE: We present a technique to prevent alar notching associated with nasolabial interpolation flaps. If early notching is noted at the time of pedicle division, preemptive placement of a skin-fat composite graft can obviate the need for additional procedures. METHODS: A case report detailing the procedure and a review of the options for repair of alar notching are provided. RESULTS. Placement of a skin-fat composite graft harvested from the divided pedicle flap resulted in correction of alar notching. CONCLUSION: This procedure is presented as an alternative to delayed cartilage grafting for repair of alar rim notching after placement of an interpolated pedicle flap. If notching is noted early, correction at the time of pedicle division allows for use of available tissue for composite grafting, avoidance of a delayed reconstructive procedure, and a good functional and cosmetic
|
1 |
Cloth Masks and Mask Sterilisation as Options in Case of Shortage of Surgical Masks and Respirators
|
Coronavirus Disease 2019 (COVID-19)
|
This three-page document aims to provide advice on the use of cloth face masks and sterilization of respirators and surgical masks as an alternative in healthcare settings with suspected or confirmed COVID-19 cases if there is a shortage of specialized surgical masks and respirators.
|
0 |
Late infection of hydroxyapatite orbital implants
|
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
|
Background: Exposure and minor complications of hydroxyapatite orbital implants are common. Infection appears to be rare and fibrovascular ingrowth into hydroxyapatite implants may make infection and extrusion less likely than with other types of orbital implant. Methods: We describe three cases of chronic low-grade infection of hydroxyapatite implants, occurring late after apparently uncomplicated surgery, with tiny or inapparent areas of conjunctival loss or exposure. Results: Two of the three cases grew Staphylococcus aureus on culture. All three implants ultimately needed to be removed. A characteristic histological pattern was seen, with abrupt transition between vascularized and abscessed implant. Conclusions: Chronic infection of hydroxyapatite implants can occur late, in the absence of large conjunctival defects, or other obvious risk factors. While exposure of the implant to pathogens through a breach in the conjunctiva may have been a factor, it appeared that the infection may have arisen in an avascular portion of the implant prior to the conjunctival breakdown in one or more of these cases
|
0 |
Acute cauda equina syndrome after total knee arthroplasty as a result of epidural anesthesia and spinal stenosis
|
Surgical Management of Osteoarthritis of the Knee CPG
|
An unusual complication of epidural anesthesia performed for routine total knee arthroplasty is presented. Epidural catheter placement or removal resulted in an acute cauda equina syndrome in a patient with asymptomatic high-grade lumbar spinal stenosis at L3-4. The case is presented along with a literature review
|
0 |
Prevention of spinal anaesthesia-induced hypotension in the elderly: i.m. methoxamine or combined hetastarch and crystalloid
|
Management of Hip Fractures in the Elderly
|
We have compared two methods of reducing hypotension during spinal anaesthesia in elderly patients, 6% hetastarch and crystalloid or methoxamine 10 mg i.m., in terms of haemodynamic stability and requirements for additional vasopressors. Sixty-two patients (aged 60-97 yr) undergoing surgical fixation of fractured neck of femur were allocated randomly to receive 6% hetastarch (Hespan) 500 ml followed by Hartmann's solution 500 ml (group HS, n = 32) or a bolus injection of methoxamine 10 mg i.m. (group MX, n = 30), 10 min before induction of spinal anaesthesia with 0.5% hyperbaric bupivacaine 2.25-3.0 ml. Arterial pressure was measured non-invasively by an oscillotonometer at 2-min intervals from 0 to 40 min and at 5-min intervals thereafter. Methoxamine 2 mg i.v. was given if systolic arterial pressure (SAP) decreased to < 100 mm Hg. Hypotension was defined as a 25% decrease from baseline SAP or mean arterial pressure (MAP). Patient data, sensory level and blood loss were similar in the two groups. SAP and MAP increased initially from baseline until induction of spinal anaesthesia and then decreased for 30 min in both groups, but remained higher in group MX (P < 0.05). Heart rate (HR) decreased from baseline in group MX (P < 0.05) and was less than in group HS at all times from 2 to 60 min (P < 0.01). The incidence of SAP hypotension (47% vs 75%; P = 0.03, odds ratio (OR) = 3.43) and MAP hypotension (47% vs 67%; P = 0.09, OR = 2.51) was less in group MX than in group HS. Requirements for rescue methoxamine i.v. (27% vs 53%, P = 0.04, OR = 3.11) was less in group MX than in group HS but the dose of rescue methoxamine given (mean 6.3 (95% confidence intervals 3.0-9.6) vs 8.9 (5.6-12.2) mg) and time to onset of hypotension (20.7 (14.5-26.7) vs 17.3 (11.4-23.1) min) were similar in groups MX and HS, respectively. We conclude that methoxamine 10 mg i.m., given 10 min before induction of spinal anaesthesia in normovolaemic elderly patients, reduced subsequent SAP and MAP hypotension, HR and requirements for rescue vasopressor therapy compared with a combination of 6% hetastarch 500 ml and crystalloid 500 ml. The previously reported benefit of such volume administration may not extend to the elderly
|
0 |
Successful use of trastuzumab with anthracycline-based chemotherapy followed by trastuzumab maintenance in patients with advanced HER2-positive Gastric Cancer
|
MSTS 2018 - Femur Mets and MM
|
Background: There is no standard chemotherapy regimen that is universally accepted for the treatment of advanced gastric cancer. Trastuzumab added to chemotherapy improves survival in patients with metastatic human epidermal growth factor receptor-2 (Her2/neu)-overexpressing gastric cancer. Data are lacking for the combination of trastuzumab with other chemotherapy regimens, apart from the cisplatin/fluorouracil backbone used in the pivotal TOGA trial. Patients and Methods: In this retrospective analysis, we included patients with gastric cancer with HER2 overexpression who received trastuzumab in addition to their first-line chemotherapy, with or without trastuzumab maintenance therapy. The end-points were response and tolerance to treatment. Results: We identified seven patients who met the search criteria; six had metastatic disease and one had locally advanced unresectable disease. Four patients received epirubicin/oxaliplatin/capecitabine/trastuzumab, and the others had non-anthracycline-based chemotherapy with trastuzumab. All patients had radiological responses to treatment - one had a complete response and six had partial responses. Among the four patients who received anthracycline-based chemotherapy with trastuzumab, there was a transient decline in cardiac ejection fraction in three, but all resolved without sequelae. All patients received a period of chemotherapy induction followed by trastuzumab monotherapy for maintenance. The median progression-free survival was 14.6 months and median overall survival was 16.4 months. Conclusion: Trastuzumab is an important agent for the treatment of HER2-overexpressing gastric cancer. We recorded an acceptable safety and efficacy profile in this small cohort treated with anthracycline-based chemotherapy with trastuzumab followed by trastuzumab maintenance.
|
0 |
The intraoperative gap difference (flexion gap minus extension gap) is altered by insertion of the trial femoral component
|
Surgical Management of Osteoarthritis of the Knee CPG
|
A Tensor/Balancer device has been recently developed in order to assess soft tissue balancing in total knee arthroplasty (TKA) under more physiological conditions. This device allows us to measure the joint gap with a trial femoral component in place with the patella reduced. The purpose of this study was to clarify whether the placement of the component changes the intraoperative gap difference (flexion gap distance minus extension gap distance). We prospectively investigated the extension (0 degrees ) and flexion (90 degrees ) gaps in 73 posterior-stabilized TKAs under 30 lb of joint distraction force. Then, we compared the gap difference with and without the trial femoral component in place. Our results showed that the intraoperative gap difference with the trial femoral component in place was larger than the intraoperative gap difference without the trial component (p=0.00003; with the trial component: mean 4.7 mm (standard deviation (SD): 3.0mm); without the trial component: mean 2.7 mm (SD: 3.3mm)). We consider that the change in gap difference with or without femoral component was caused by a relative difference in the elasticity and/or tightness of the soft tissue in extension versus flexion. Surgeons should be aware of this effect of the femoral component when considering intraoperative soft tissue balancing which leads to postoperative stability of the knee joint consequently
|
0 |
Combined two foot flaps with iliac bone graft for reconstruction of the thumb
|
DoD LSA (Limb Salvage vs Amputation)
|
UNLABELLED: The purpose of this report was to retrospectively review the results of reconstruction of the thumb by use of combined two foot flaps with an iliac bone graft. From 2009 to 2014, nine patients with traumatic amputation of the thumb had their thumbs reconstructed. The two flaps were based on one pedicle. All flaps survived completely. Patients were followed for a mean of 15.6 months (range, 6-35 months). The appearance of the reconstructed thumb was comparable to a normal one, except for one thumb which required debulking. The appearance of the nail was satisfactory without deformity. The range of joint motion was satisfactory. The two point discrimination of the pulp ranged from 6 mm to >15 mm. The Michigan Hand Questionnaire outcome score was a mean of 76.2 +/- 11.3 points and the Maryland foot rating score a mean of 94.8 +/- 3.4 points. The combined two foot flaps with iliac bone graft might provide an option for the reconstruction of the thumb. LEVEL OF EVIDENCE: III.
|
1 |
Continuous femoral nerve block versus patient-controlled analgesia following total knee arthroplasty
|
Surgical Management of Osteoarthritis of the Knee CPG
|
PURPOSE: To compare total knee arthroplasty (TKA) patients who received continuous femoral nerve block (FNB) with local anaesthetics through a catheter versus patient-controlled analgesia (PCA) with intravenous morphine. METHODS: 50 women and 10 men aged 51 to 84 years with matched characteristics underwent TKA and received either continuous FNB with local anaesthetics through a catheter (n=30) or PCA with intravenous morphine (n=30). None of the patients had had previous knee surgery. All operations were performed according to the standard protocol. Daily mean pain numerical rating scale at rest (NRS-R) and during movement (NRS-M), requirement of extra pain control, complications related to pain control, and overall patient satisfaction in both groups were compared. RESULTS: Both groups were similar in terms of pain NRS-R and NRS-M, overall satisfaction, and length of hospital stay. Within each group, pain NRS-M score was significantly higher than pain NRS-R score. In the FNB group, 3 patients had dislodgement of the femoral catheter on day 1 and switched to PCA with intravenous morphine. Two of them had fair satisfaction. Patients in the PCA group had significantly more side-effects (nausea, vomiting, dizziness, and pruritis); 2 of the 5 patients with nausea and vomiting had fair satisfaction. No patients had any surgical complication. CONCLUSION: Both FNC and PCA provide reliable pain control
|
0 |
Glenoid implant orientation and cement failure in total shoulder arthroplasty: a finite element analysis
|
Glenohumeral Joint OA
|
BACKGROUND: To minimize glenoid implant loosening in total shoulder arthroplasty (TSA), the ideal surgical procedure achieves correction to neutral version, complete implant-bone contact, and bone stock preservation. These goals, however, are not always achievable, and guidelines to prioritize their impact are not well established. The purpose of this study was to investigate how the degree of glenoid correction affects potential cement failure.
METHODS: Eight patient-specific computer models were created for 4 TSA scenarios with different permutations of retroversion correction and implant-bone contact. Two bone models were used: a homogeneous cortical bone model and a heterogeneous cortical-trabecular bone model. A 750-N load was simulated, and cement stress was calculated. The risk of cement mantle fracture was reported as the percentage of cement stress exceeding the material endurance limit.
RESULTS: Orienting the glenoid implant in retroversion resulted in the highest risk of cement fracture in a homogeneous bone model (P < .05). In the heterogeneous bone model, complete correction resulted in the highest risk of failure (P = .0028). A positive correlation (rho = 0.901) was found between the risk of cement failure and amount of exposed trabecular bone.
CONCLUSIONS: Incorporating trabecular bone into the model changed the effect of implant orientation on cement failure. As exposed trabecular bone increased, the risk of cement fracture increased. This may be due to shifting the load-bearing support underneath the cement from cortical bone to trabecular bone.
|
0 |
Bisphosphonate osteonecrosis (BON): unanswered questions and research possibilities
|
MSTS 2018 - Femur Mets and MM
|
Bisphosphonate osteonecrosis (BON) is a relatively recent adverse drug event that affects the oral cavity almost exclusively. It has been reported in individuals with metastatic breast, prostate, and lung cancer as well as in multiple myeloma. It has also been reported in a small subset of individuals who have been treated with bisphosphonate therapy for osteoporosis and Paget's disease of bone. Published studies to date have been characterized by relatively small sample sizes. Based on these studies, incidence appears to range between 0.1% and 11% depending on the population being studied and a number of other co-factors that have not been completely understood. The pathobiology of BON has not been fully elucidated and risk factors involved in the process need confirmation. Patients with this complication have altered quality of life and can suffer from discomfort and pain. Management is difficult and, while many treatment protocols have been proposed, at best they have only had partial success. This review of literature discusses a number of issues involving BON, with focus on the definition, possible association of BON and bisphosphonate therapy, pathobiology of BON and several additional research questions that need further investigation. [References: 118]
|
0 |
How the COVID-19 pandemic is affecting paediatric orthopaedics practice: a preliminary report
|
Coronavirus Disease 2019 (COVID-19)
|
PURPOSE: Since the state of alarm was decreed in Spain on 14 March 2020, the coronavirus disease 2019 (COVID-19) pandemic has had an extraordinary impact in paediatric hospitals. This study shows the effect of the pandemic on our practice in paediatric orthopaedics in a referral third level paediatric hospital. METHODS: We performed a single-centre retrospective review of the official census from a third level paediatric hospital from 14 March to 14 April for the years 2018, 2019 and 2020. RESULTS: The patients seen in our clinic during this period in 2020 decreased in by 82% (p < 0.001) compared with 2018 and 2019, however, the number of telemedicine consultations increased by 90.21% (p < 0.001). The total number of patients attending the clinic (including onsite and virtual) was reduced by 54.25% (p < 0.001). The total surgeries performed plummeted by 81% in this period in 2020 (p < 0.001) due to a reduction in elective cases of 94.6% (p < 0.001). No significant decrease was found in the number of urgent surgical cases per day in 2020 (p = 0.34). Finally, the number of orthopaedic patients admitted to our emergency department dropped by 78.6% during the state of alarm (p < 0.001). CONCLUSION: According to our results, the pandemic has significantly affected our daily practice by decreasing elective surgeries and onsite clinics, but other activities have increased. As we have implemented telemedicine and new technologies to adapt to this setback, we should take advantage of the situation to change our practice in the future to better allocate our health resources and to anticipate outbreaks. Published without peer review. LEVEL OF EVIDENCE: IV.
|
0 |
Sources of processed lipoaspirate cells: influence of donor site on cell concentration
|
Panniculectomy & Abdominoplasty CPG
|
BACKGROUND: Recently, adipose tissue harvested by liposuction has been identified as a source of processed lipoaspirate cells. The aim of this study was to determine the concentration of processed lipoaspirate cells in adipose tissue obtained by liposuction from different harvest areas in women. METHODS: A prospective cross-sectional study was conducted in 25 women in whom liposuction in four or more different zones in the same procedure was indicated. After selective liposuction, the material was sent to the laboratory, where it was processed for extraction of processed lipoaspirate cells, which were separated from the adipose tissue, quantified, and characterized through determination of c-kit expression. The following harvest regions were evaluated: upper abdomen, lower abdomen, trochanteric region, inner thigh, knee, and flank. The cell concentration obtained at each site was compared by analysis of variance for mixed models. RESULTS: A significant difference was found for cell concentration obtained at the different harvest sites. The cell concentration in the lower abdomen was greater than in other areas, but no significant difference was found in relation to the inner thigh. CONCLUSIONS: The lower abdomen and the inner thigh may have higher processed lipoaspirate cell concentrations. These sites may turn out to be better sources of adult mesenchymal stem cells.
|
0 |
Tumescent technique for regional anesthesia permits lidocaine doses of 35 mg/kg for liposuction
|
Panniculectomy & Abdominoplasty CPG
|
The tumescent technique for local anesthesia permits regional local anesthesia of the skin and subcutaneous tissues by direct infiltration. The tumescent technique uses large volumes of a dilute anesthetic solution to produce swelling and firmness of targeted areas. This investigation examines the absorption pharmacokinetics of dilute solutions of lidocaine (0.1% or 0.05%) and epinephrine (1:1,000,000) in physiologic saline following infiltration into subcutaneous fat of liposuction surgery patients. Plasma lidocaine concentrations were measured repeatedly over more than 24 hours following the infiltration. Peak plasma lidocaine levels occurred 12-14 hours after beginning the infiltration. Clinical local anesthesia is apparent for up to 18 hours, obviating the need for postoperative analgesia. Dilution of lidocaine diminishes and delays the peak plasma lidocaine concentrations, thereby reducing potential toxicity. Liposuction reduces the total amount of lidocaine absorbed systemically, but does not dramatically reduce peak plasma lidocaine levels. A safe upper limit for lidocaine dosage using the tumescent technique is estimated to be 35 mg/kg. Infiltrating a large volume of dilute epinephrine assures diffusion throughout the entire targeted area while avoiding tachycardia and hypertension. The associated vasoconstriction is so complete that there is virtually no blood loss with liposuction. The tumescent technique can be used with general anesthesia or IV sedation. However, with appropriate instrumentation and surgical method, the tumescent technique permits liposuction of large volumes of fat totally by local anesthesia, without IV sedation or narcotic analgesia.
|
0 |
Enoxaparin prevents progression of stages I and II osteonecrosis of the hip
|
AAHKS (2) Corticosteroids
|
UNLABELLED: In a prospective pilot study, we hypothesized that enoxaparin (60 mg/day for 12 weeks) would prevent progression of Stages I and II osteonecrosis of the hip associated with thrombophilia or hypofibrinolysis or both over > or = 108 weeks of followup versus untreated historic controls, with different treatment responses in primary versus corticosteroid-associated secondary osteonecrosis. Patients with one or more thrombophilic-hypofibrinolytic disorder and Ficat Stages I or II osteonecrosis of at least one hip were included. A blinded committee interpreted anteroposterior and frog-leg lateral radiographs at entry in the study and every 36 weeks to > or = 108 weeks. Maintenance of the disease at Stages I and II versus progression of the osteonecrosis to Stages III and IV requiring total hip replacement was the major end point. Sixteen patients had primary osteonecrosis (25 hips; 13 Stage I, 12 Stage II), and 12 had secondary osteonecrosis (15 hips; five Stage I, 10 Stage II). With no Enoxaparin-related complications, 19 of 20 hips (95%) with primary osteonecrosis were unchanged from Stages I and II osteonecrosis at > or = 108 weeks; 12 of 15 hips (80%) with secondary osteonecrosis progressed to Stages III and IV osteonecrosis. In primary osteonecrosis at > or = 108 weeks, survival of 95% hips, or 76% (19/25 hips, based on intent to treat), compared favorably with untreated historical controls (approximately 20% 2-year survival), comparable to 20% survival in secondary hip osteonecrosis. Enoxaparin may prevent progression of primary hip osteonecrosis, decreasing the incidence of total hip replacement.
LEVEL OF EVIDENCE: Therapeutic study, II-1 (prospective cohort study).
|
1 |
Carpal tunnel syndrome: diagnosis with high-resolution sonography
|
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
|
OBJECTIVE: Carpal tunnel syndrome is characterized by typical anatomic changes that can be shown with high-resolution sonography. To determine whether these findings are reliable and can be used to establish the diagnosis, sonograms of patients with the disease were compared with sonograms obtained in patients with normal wrists. Also compared were sonograms and MR images obtained in the patients with carpal tunnel syndrome. SUBJECTS AND METHODS: Twenty wrists in 18 consecutive patients with clinical symptoms of carpal tunnel syndrome and with abnormal nerve conduction studies were examined with real-time sonography and MR imaging. The sonograms and MR images were evaluated quantitatively by two unbiased observers with regard to the size and shape of the median nerve and the palmar bowing of the flexor retinaculum. A t test was used to compare these data with those from previous sonographic studies of 28 normal wrists. Correlation coefficients for the measurements obtained with sonography and with MR were calculated. The relative accuracies of different diagnostic criteria for the diagnosis of carpal tunnel syndrome were assessed by using receiver-operating-characteristic analytical techniques. RESULTS: Characteristic findings on both MR and CT scans of the 20 wrists with carpal tunnel syndrome included swelling of the median nerve in the proximal part of the carpal tunnel in 16 wrists, flattening of the median nerve in the distal part of the carpal tunnel in 13 wrists, and increased palmar bowing of the flexor retinaculum in nine wrists. Comparison with the data of 28 normal wrists proved that these findings were significant (p less than .01 to p less than .001). Receiver-operating-characteristic analysis showed that the discrimination between wrists in normal subjects and in patients with carpal tunnel syndrome achieved with each of the three diagnostic criteria was not significantly different. Measurements of the size and flattening of the median nerve obtained from sonograms were similar to those on MR images, whereas sonography was less accurate for measuring the palmar bowing of the flexor retinaculum. CONCLUSION: We conclude that the results of sonography are reliable, and that the diagnosis of carpal tunnel syndrome can be established on the basis of sonographic findings
|
0 |
A comparison of mobile-bearing versus fixed-bearing total knee arthroplasty
|
Surgical Management of Osteoarthritis of the Knee CPG
|
Background: Currently there are various knee prosthesis designs available each with its plus and minus points; there is no general consensus on whether mobile-bearing knees are functionally better than fixed-bearing ones. This study is designed to compare outcomes after total knee arthroplasty with both of the above prostheses. Material s and Methods: 50 patients (68 knees) who'd had a total knee arthroplasty between April 1999 and April 2008 at both Akhtar and Kian Hospitals for primary osteoarthritis were selected. In 30 cases a fixed-bearing knee (Scorpio(registered trademark), Stryker) and in the remaining 38 a mobile-bearing prosthesis (Rotaglide(registered trademark), Corin Group) was used. Patients' knees were scored before and after the operation according to the Knee Society Scoring System. The mobile-bearing group had an average age of 65 and 34 months' follow-up; in the fixed-bearing group the average age was 69 and the average follow-up 30 months. Results: The average knee score in the mobile-bearing group rose from 29 to 64 while in the fixed-bearing group the score changed from 31 to 68. The average functional score moved from 45 to 67 in the mobile-bearing group and from 34 to 57 in the fixed-bearing group. The average overall score, for the fixed-bearing group, moved from 65 to 125 and in the mobile-bearing group from 75 to 128. Conclus ion: In both groups the average knee/functional knee scores increased after the operation and all patients were happy with the results, however statistically there was no meaningful relationship between pre-and postoperation scores. So regarding to our findings, there is no preference between these two types of prosthesis
|
0 |
A National Analysis of Complications Following Total Hip Replacement in Patients With Chronic Obstructive Pulmonary Disease
|
PJI DX Updated Search
|
Patients with chronic obstructive pulmonary disease (COPD) have a high risk of osteoporosis and fractures. The incidence rate of hip fracture has steadily increased over time and is a major common event in patients with osteoporosis and COPD. Total hip replacement (THR) is commonly performed in patients with hip fracture. Our aim was to compare the complications of THR between patients with and without COPD.Longitudinally linked data from the National Health Insurance Research Database, which consists of registration, claims, and reimbursement records, for a cohort of 1,000,000 randomly selected enrollees traced retrospectively from 1996 to 2000 in Taiwan. Patients who had undergone THR surgery between January 1, 2004, and December 31, 2008, were identified and divided into COPD and non-COPD cohorts. Outcomes and complications, including 90-day mortality, 1-year mortality, 1-year wound infection, 30-day readmission for hospitalization, 30-day pneumonia, 30-day acute respiratory failure, 30-day cerebrovascular accident, and length of stay during hospitalization, were measured after THR.The COPD group had a significantly higher ratio of complications, including 30-day readmission (14.0% vs 8.4%), 30-day pneumonia (10.4% vs 4.4%), 30-day acute respiratory failure (1.5% vs 0.5%), 1-year mortality (6.9% vs 2.7%), and length of stay in the hospital (10.6% vs 0.8%) than the non-COPD group.In addition to airway diseases, patients in the COPD group had higher mortality than those in non-COPD group after THR. Surgeons should give more attention to airway evaluation and selection of patients with COPD for THR
|
1 |
Endoprosthetic replacement for malignant bone tumours of the proximal femur
|
MSTS 2018 - Femur Mets and MM
|
Limb salvage procedures are considered the gold standard in the treatment of bone tumours. The use of modular prostheses is one of the options for reconstruction after bone resection in primary tumours and in very restricted cases also in bone metastases. The authors report the results of 27 consecutive cases of proximal femur bone resections and reconstructions with modular prostheses, using the Mutars system. Soft tissue reconstruction and anchorage to the implant was performed using the Trevira tube. The system stem used showed good mechanical resistance, and implant removal was required for infection in only two cases. Functional results were related to the degree of bone resection and muscular sacrifice. © Wichtig Editore, 2005.
|
0 |
The distal radial decompression osteotomy for ulnar impingement syndrome
|
Distal Radius Fractures
|
INTRODUCTION: The decompression of the distal radioulnar joint (DRUJ) is performed by ulnar translation of the radial shaft proximal to the sigmoid notch, i.e. detensioning of the distal part of the interosseous membrane (DIOM) while containment of the DRUJ is achieved by closed wedge osteotomy of the radius. The osteotomy shortens the radius which entails detensioning of the triangular fibrocartilage complex (TFCC).
SURGICAL TECHNIQUE: Facilitating the modified Henry approach to the distal palmar radius a radial based wedge osteotomy is applied. The proximal osteotomy is proximal to the ulnar head and distal osteotomy is proximal to the sigmoid notch to prevent iatrogenic impingement. Ulnar translation of the radial shaft is performed to loosen the DIOM. The closed wedge osteotomy reduces radial inclination which will foster containment of the DRUJ.
CONCLUSION: Distal radial decompression osteotomy of the DRUJ preserves DRUJ function while relieving painful impingement. Further surgical interventions are not compromised in case of failure.
|
0 |
Management of osteochondritis dissecans of the knee
|
Osteochondritis Dissecans 2020 Review
|
The etiology of osteochondritis dissecans is hypothesized as repetitive microtrauma, resulting in an interruption of blood supply. Due to the location of the most common lesions on the medial femoral condyle, impingement of either the medial tibial spine or inferior pole of the patella against the adjacent medial femur may be responsible. It is much more common in athletic males than other groups. This article reviews the current treatment options for lesions around the knee.
|
0 |
Tapentadol vs oxycodone/naloxone in the management of pain after total hip arthroplasty in the fast track setting: an observational study
|
AAHKS (4) Acetaminophen
|
BACKGROUND: In recent years, joint replacement surgery has gradually progressed towards the fast-track model, and early rehabilitation immediately after surgery is regarded fundamental for optimal recovery of function: the aim of the present study is to describe the efficacy in perioperative management of pain in patients undergoing total hip replacement surgery and treated with tapentadol or oxycodone/naloxone in combination with ketoprofene.
METHODS: Single-center retrospective study on patients with moderate-severe pain, referred to total hip replacement. Patients received either tapentadol (100 mg/twice-daily post-surgery - treatment group) or oxycodone/naloxone (10 mg/5 mg post-surgery - control group) plus ketoprofen 100 mg/ twice daily. Supplemental analgesia (paracetamol 1 g or morphine 0,1 mg/kg sc) was provided if needed. Pain at rest and pain during movement were evaluated on a daily basis for 4 days post-op, after which patients were usually discharged. All adverse events were reported and compared between the two groups.
RESULTS: 106 patients were analyzed in the tapentadol group and compared to 105 patients treated with oxycodone/naloxone. Both pain intensity at rest and upon movement were significantly lower in the tapentadol group at all follow-up times (p < 0.001). Throughout T1-T4, supplemental analgesia was needed by significantly less tapentadol patients compared to the control group. Similarly, regarding side effects, a significantly higher occurrence of post-op nausea, vomit, itching and constipation was observed in the control group (p < 0.001 in all cases).
CONCLUSION: Results from the present study support the use of tapentadol in combination with ketoprofen for the management of moderate-severe pain in the setting of major orthopedic surgery, given its effectiveness in reducing pain intensity, and its satisfactory tolerance.
|
0 |
Septic Arthritis Caused by Chryseobacterium meningosepticum in an Elbow Joint Prosthesis
|
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
|
Chryseobacterium meningosepticum is a Gram-negative bacillus historically associated with meningitis and sepsis in premature neonates. Clinicians should suspect this organism when Gram-negative bacilli are seen on Gram-stain and culture, particularly in immunocompromised patients, and in cases of disrupted host tissue integrity. We report the first case of septic arthritis due to this orgranism
|
1 |
Total Hip Arthroplasty Using a Cylindrical Cementless Stem in Patients With a Small Physique
|
Developmental Dysplasia of the Hip CPG
|
We performed total hip arthroplasty using an anatomic medullary locking cementless stem for small-physique patients from 1988 to 1995. We conducted a retrospective study of 50 joints in 44 cases, including 40 developmentally dysplastic hips followed for 12 to 20 years (average, 15.1 years). Average height and body weight were 152 cm and 56 kg (5.0 ft and 124 lb), respectively, with an average body mass index of 24.2. Twelve joints (24%) were revised for acetabular-sided failures. Forty-eight stems (96%) showed bone ingrowth fixation, and there were no unstable stems. The simple cylindrical shape of the distal portion of the AML stem was less affected by deformity of the proximal femur of developmental dysplasia of the hip in patients with a small physique, and both clinically and radiologically good results were confirmed at long-term follow-up. (copyright) 2011 Elsevier Inc
|
0 |
Transdermal fentanyl patch for postoperative analgesia in total knee arthroplasty: A randomized double-blind controlled trial
|
Surgical Management of Osteoarthritis of the Knee CPG
|
Purpose: To assess the efficacy of a transdermal fentanyl patch (TFP) (50 (mu)g/hour) applied 10-12 hours before surgery versus placebo for postoperative pain control of total knee arthroplasty (TKA). Materials and methods: We enrolled 40 patients undergoing elective TKA under spinal anesthesia using isobaric or hyperbaric bupivacaine. Subjects were randomized to receive a TFP (Duragesic (registered trademark) 50 (mu)g/hour) or placebo patch applied with a self-adhesive to the anterior chest wall 10-12 hours before spinal anesthesia. Every patient was given patient-controlled morphine for postoperative pain control. Patients were evaluated every 4 hours until 48 hours. Results: Morphine consumption at 24 and 48 hours in the TFP group versus the placebo group was15.40(plus or minus)12.65 and 24.90(plus or minus)20.11 mg versus 33.60(plus or minus)19.06 and 57.80(plus or minus)12.65 mg (P(less-than or equal to)0.001). Numeric rating scale scores at rest and during movement over 48 hours were lower in the TFP group. Ambulation and nausea/vomiting scores were statistically greater, but not clinically significant in the TFP group. Sedation scores were low and not statistically significantly different between groups. There was no severe respiratory depression. Conclusion: TFP (50 (mu)g/hour) applied10-12 hours before surgery can effectively and safely decrease morphine consumption and pain scores during the first 48 hours after TKA surgery. (copyright) 2014 Sathitkarnmanee et al
|
0 |
Urban Congolese Refugees in Kenya: The Contingencies of Coping and Resilience in a Context Marked by Structural Vulnerability
|
DoD PRF (Psychosocial RF)
|
The global increase in refugee migration to urban areas creates challenges pertaining to the promotion of refugee health, broadly conceived. Despite considerable attention to trauma and forced migration, there is relatively little focus on how refugees cope with stressful situations, and on the determinants that facilitate and undermine resilience. This article examines how urban Congolese refugees in Kenya promote psychosocial well-being in the context of structural vulnerability. This article is based on interviews ( N = 55) and ethnographic participant observation with Congolese refugees over a period of 8 months in Nairobi in 2014. Primary stressors related to scarcity of material resources, political and personal insecurity, and emotional stress. Congolese refugees mitigated stressors by (a) relying on faith in God's plan and trust in religious community, (b) establishing borrowing networks, and (c) compartmentalizing the past and present. This research has broader implications for the promotion of urban refugees' psychosocial health and resilience in countries of first asylum.
|
0 |
Risk classification for primary knee arthroplasty
|
Surgical Management of Osteoarthritis of the Knee CPG
|
We devised a 4-group classification for primary TKA patients: C0, fit patient, simple arthritis; CI, fit patient, complex arthritis; CII, medically unfit patient with simple pattern; and CIII, unfit patient with complex arthritis. Patient fitness and arthritis complexity were based on the literature. One hundred twenty-two patients, operated on by the senior author, were retrospectively placed into one of these 4 groups. We found the following: significantly increased cumulative complication risk in CII and CIII incomparison with C0 (P < .001), increased length of stay in CII and CIII (P < .001), and similar trends between C0 and CI and between CI and CII. This system is useful in preoperative planning, risk counseling, and surgeon selection. It identifies patients with a higher risk of complications and inpatient stay
|
1 |
10-Min 3D Turbo Spin Echo MRI of the Knee in Children: Arthroscopy-Validated Accuracy for the Diagnosis of Internal Derangement
|
Osteochondritis Dissecans 2020 Review
|
BACKGROUND: Ten-minute MRI of the pediatric knee can add value through increased cost-effectiveness and decreased sedation needs but requires validation of its clinical efficacy. PURPOSE: To determine the arthroscopy-based diagnostic accuracy and interreader reliability of 10-min 3D Controlled Aliasing In Parallel Imaging Results In Higher Acceleration (CAIPIRINHA) turbo spin echo (TSE) MRI with two isotropic pulse sequences for the diagnosis of internal derangement in children with painful knee conditions. STUDY TYPE: Prospective. SUBJECTS: Sixty children. FIELD STRENGTH/SEQUENCE: 3T, gradient echo-based scout with automatic anatomical landmark recognition and plane prescription, 3D CAIPIRINHA SPACE TSE. ASSESSMENT: Three fellowship-trained musculoskeletal radiologists evaluated the MRI studies independently and resolved discrepancies through consensus. Outcome variables included image quality, motion artifacts, meniscal abnormalities, anterior and posterior cruciate ligament tears, and cartilage lesions. Arthroscopic surgery served as the standard of reference, which was performed after 37 (range, 1-143) days post-MRI. STATISTICAL TESTS: Diagnostic accuracy analysis of MRI with arthroscopic surgery as the standard of reference. Reliability analysis through calculation of interreader agreements with kappa statistics. RESULTS: All studies were suitable for diagnostic interpretation with good-to-very-good image quality ratings and little-to-no motion degradation ratings in the majority of cases. The sensitivities/specificities/accuracies of 3D CAIPIRINHA TSE MRI were 0.93/0.96/0.94 for 15/60 (25%) medial meniscal tears, 0.95/0.92/0.94 for 21/60 (35%) lateral meniscal tears, 0.83/1.00/0.92 for 6/60 (17%) discoid menisci, 1.00/0.98/0.99 for 16/60 (27%) anterior cruciate ligament tears, 1.0/1.0/1.0 for 2/60 (3%) posterior cruciate ligament tears, 1.00/1.00/1.00 for 5/60 (8%) osteochondritis dissecans lesions, 0.71/0.96/0.84 for 48 (13%) defects in 360 cartilage segments, and 0.85/0.97/0.91 overall. The interreader agreements were overall good-to-very-good (kappa, 0.72-1.00). DATA CONCLUSION: The clinical use of 10-min 3D CAIPIRINHA TSE MRI of the knee in children with painful knee conditions yields an overall high arthroscopy-validated diagnostic accuracy of 91% and good-to-very good interreader reliability for the diagnosis of internal knee derangements. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 6 J. Magn. Reson. Imaging 2019;49:e139-e151.
|
0 |
Subarachnoid and intraventricular hemorrhage due to ruptured aneurysm after combined spinal-epidural anesthesia
|
PJI DX Updated Search
|
A patient received combined spinal-epidural anesthesia for a scheduled total knee arthroplasty. After an injection of spinal anesthetic and ephedrine due to a decrease in blood pressure, the patient developed a severe headache. The patient did not respond to verbal command at the completion of the operation. A brain CT scan revealed massive subarachnoid and intraventricular hemorrhages, and a CT angiogram showed a ruptured aneurysm. Severe headaches should not be overlooked in an uncontrolled hypertensive patient during spinal anesthesia because it may imply an intracranial and intraventricular hemorrhage due to the rupture of a hidden aneurysm. é Yonsei University College of Medicine 2010
|
0 |
Reconstruction of the thumb amputation at the carpometacarpal joint level by groin flap and second toe transfer
|
DoD LSA (Limb Salvage vs Amputation)
|
INTRODUCTION: Traumatic loss of thumb at the carpometacarpal (CMC) joint level is very disabling to an individual. Pollicisation is the recommended technique of reconstruction for loss of thumb at this level. On occasions, injury to the rest of the hand or amputation of additional fingers may make pollicisation an impossible option. Microsurgical transfer of second toe is an option in such situations. Although many large series of toe transfers are available in the literature, no series deals exclusively with this subset of patients. MATERIALS AND METHODS: Eight patients who had amputation of the thumb at or proximal to the CMC joint level were reconstructed by second toe transfer by us in the period 2002-2011. All had preliminary groin flap cover in the area of the thumb during the acute stage of treatment. Second toe with the metatarsal was transferred for thumb reconstruction after a mean duration of 3 months after flap cover. Patients were assessed for their ability to pinch, hold large objects and opposition achieved by Kapandji score. Average follow up is 4 years and 6 months with a minimum of 1 year. RESULTS: All toe transfers survived. They reached their maximum functional potential by 1 year. All patients actively used the reconstructed thumb for day to day activities. Pinch was possible in all patients except two patients who did not have any fingers. Six of them registered grip strength of at least 50% of the opposite hand. When fingers were present, opposition was possible in all patients with Kapandji scores ranging from 5 to 8. Extent of usage was less in patients who did not have good function in other fingers. CONCLUSION: Second toe transfer is a viable option for reconstruction of thumb loss at or proximal to the CMC joint level. Proper planning of the preliminary flap cover determines the length of the thumb reconstruction. Strategic position of the transferred toe of adequate length and the functional status of the other fingers are important determinants of functional outcome.
|
1 |
Vascular injuries in compound fractures of the leg with initially adequate circulation
|
DoD SSI (Surgical Site Infections)
|
We carried out a randomised, controlled trial in 157 patients who had isolated severe Gustilo type-IIIa and type-IIIb fractures of the metaphysis or diaphysis of the leg to determine the prevalence of vascular injuries and the role of vascular repair. All patients had stable vital signs and clinically adequate circulation in their legs before operation. In a control group of 64 patients we performed conventional surgery with systematic debridement and primary stabilisation of the fractures. In the trial group of 93 patients the major vessels and nerves adjoining the compound fracture were routinely explored and repaired when necessary after the initial procedure. Two of the 28 control patients (7.1%) with type-IIIb compound fractures had signs of inadequate circulation after the first operation. Both had major vascular injuries which were demonstrated at a second procedure. In the trial group, major vascular injuries were found in two of 54 patients (3.7%) with type-IIIa and 11 of 39 patients (28.2%) with type-IIIb compound fractures. Compared with the control group the trial group showed improved results at both the immediate and long-term follow-up. Routine exploration and early repair of injured major vessels of the leg in severe compound fractures gave encouraging results.
|
1 |
Advantages and disadvantages of the prone position in the surgical treatment of supracondylar humerus fractures in children. A literature review
|
Pediatric Supracondylar Humerus Fracture 2020 Review
|
INTRODUCTION: Supracondylar humerus fractures are the most common elbow injuries in children. The widely adopted approach for Gartland III extension type consists of closed reduction and percutaneous pinning; the pin configuration can be lateral or crossed in relationship with the habit of the surgeons. Iatrogenic injury of the ulnar nerve is the most common risk during the insertion of the medial pin. The aim of this study was to analyze advantages and disadvantages of percutaneous pinning with the patient in prone position. MATERIALS AND METHODS: A literature review of the period 2005-2017 was carried out; four medical search engine (Pubmed, Cochrane Library, ISI Web of Science and Scopus) were consulted using the review's filter and the key words "Ulnar nerve AND supracondylar humerus fractures". The total number of patients were analyzed for: ulnar nerve injuries, anesthesiologic management, time of surgery. RESULTS: Twenty-nine papers were read, 23 regarding cross pinning in supine position and 6 in prone position. On one hand, 1529 children were treated with closed reduction and cross pinning in supine position; 69 of these patients (4.5%) suffered from iatrogenic ulnar nerve injury. On the other hand, 579 patients underwent the same treatment in prone position; no ulnar nerve lesions were reported in this group. Only one article compared both groups of children in supine and prone position regarding time of anesthesia which is slightly higher in the prone group. There were no differences between supine and prone positions regarding x-ray exposition, time of surgery, closed reduction manoeuvers, pin positioning, x-ray results, clinical and functional results. DISCUSSION AND CONCLUSIONS: The ulnar nerve in children is hypermobile in the cubital tunnel and tends to dislocate anteriorly over the medial epicondyle, especially when the elbow is in hyperflexion. This may be the reason of the increased risk of nerve injury during the insertion of the medial pin in supine position and, instead, an advantage of the prone position. The insertion of both pins from the lateral side could reduce this complication. Larger studies need to be carried out regarding the reported higher duration of anesthesia in prone position.
|
0 |
Does open fasciotomy contribute to morbidity and mortality after acute lower extremity ischemia and revascularization?
|
DoD SSI (Surgical Site Infections)
|
A retrospective review was undertaken of 127 lower extremity fasciotomies performed for compartment syndrome after acute ischemia and revascularization in 73 patients with vascular trauma and 49 patients with arterial occlusive disease. One hundred twelve (88%) fasciotomies were performed early (at the time revascularization); 15 (12%) were delayed because of late compartment syndrome diagnosis. Ninety-four (77%) patients had more than one accepted indication for fasciotomy. Double-incision fasciotomy was used in 98 (77%) extremities, single-incision fasciotomy was used in 19 (15%), and fasciotomy-fibulectomy was used in 10 (8%). Fasciotomies were closed in 88 (69%) patients an average of 14 days after surgery. Seven patients needed multiple skin grafting procedures or myocutaneous flaps to close the wound; none compromised limb salvage. Five other patients had minor wound infections that resolved. Functional status returned to preoperative levels by the time of discharge from the hospital in 59 (48%) patients. Thirty-one (24%) patients had residual lower extremity disability related to delayed union of the fracture (five), chronic neuropathy (20), leg swelling (one), or ischemic nonhealing fasciotomy wounds (three); two patients had unrelated disabilities. Fourteen (11%) amputations were required for refractory limb ischemia; two (1.6%) were required for wet gangrene of the foot, which infected the fasciotomy site; the others had open noninfected incisions. Eighteen (15%) patients died of cardiopulmonary failure or multisystem failure or both, without fasciotomy-related problems. Open fasciotomy for compartment syndrome after acute lower extremity ischemia and revascularization was associated with an increased risk of minor wound morbidity. However, limb loss and death resulted from persistent ischemia and underlying systemic disease processes or injuries, but not from open fasciotomy wound complications.
|
0 |
Elucidating Determinants of Survival Disparities Among a Real-world Cohort of Metastatic Breast Cancer Patients: A National Cancer Database Analysis
|
MSTS 2022 - Metastatic Disease of the Humerus
|
Background: Disparities in breast cancer survival by race/ethnicity and socioeconomic status have been reported. However, it is unclear if these findings are reproducible among subpopulations. This study aimed to assess if socially oriented factors are predictive of overall survival (OS) among patients with hormone receptor-positive (HR+), human epidermal growth factor 2-positive (HER2+) metastatic breast cancer (MBC). Patients and Methods: We analyzed patients with MBC included in the National Cancer Database diagnosed with HR+ and HER2+ disease treated between 2010 and 2015. Multivariate analyses describe the association between non-clinical prognostic factors and OS. A matched analysis, which balanced prognostic factors between whites and African Americans (AA), was also conducted. Results: Of the 6200 patients analyzed, the majority were 50 years or older, white, and treated with hormonal therapy. Disparities in OS were observed; multivariate analysis revealed diminished survival was associated with low income (< $38K vs. = $63K, hazard ratio [HR], 1.30; P <.001), having government insurance (government vs. private, HR, 1.55; P <.001), living closer to one's treatment facility (< 4 miles vs. = 18 miles, HR, 1.16; P =.04), and being AA (AA vs. white, HR, 1.20; P =.006). The mortality disparity attributed to race was insignificant in the matched analysis (AA vs. white, HR, 1.13; 95% confidence interval, 0.98-1.30; P =.09). Conclusions: This study confirms that the known sociodemographic disparities in OS among patients with MBC are similar within the HR+/HER2+ subpopulation. The discordance of outcomes between matched and unmatched analysis demonstrate that there is a highly vulnerable subgroup of AAs. Further investigation is required to determine if the identified associations are independently causal of poor prognosis.
|
0 |
Slipped capital femoral epiphysis in children aged less than 10 years
|
DoD SSI (Surgical Site Infections)
|
Slipped capital femoral epiphysis (SCFE) is rare in children aged less than 10 years, and its management in this age group raises a number of different considerations. We present a series of 10 children aged less than 10 years who presented with SCFE to our institution between 1993 and 2005. Case notes and radiographic review were carried out. There were six boys and four girls, with an age range of 5.2-9.9 years. Mean follow-up was 50 months (22-90). The mean duration of symptoms was 54 days (1-196). Five cases were bilateral. The second slip occurred at a mean interval of 14 months (11-22) after the first slip. There were 12 stable and three unstable slips. One child had hypothyroidism and another oculocutaneous albinism. The remaining children had normal genetic and endocrine profiles. Six children were severely obese, one obese, two overweight, and one within the normal range. Multiple pins were used in nine hips and a single cannulated screw was used in six hips. Complications include loss of fixation in five hips treated with multiple pins, which were revised between 2 months and 2 years from the initial surgery, and one superficial wound infection. There were no cases of avascular necrosis or chondrolysis. In conclusion, obesity is closely related to the development of SCFE in younger children. A technique that preserves physeal growth should be used for in-situ fixation. Multiple pins preserve capital femoral physeal growth, but at the cost of a high complication rate. Strong consideration for prophylactic pinning of the contralateral hip is recommended.
|
0 |
The painful knee after total knee arthroplasty: Evaluation and management
|
OAK 3 - Non-arthroplasty tx of OAK
|
Total knee arthroplasty (TKA) is the treatment of choice for end-stage osteoarthritis of the knee. The aging of population and the need to maintain high quality of life have increased the demand for TKA. Although considered a successful procedure, 15-30% of patients presenting persistent pain. The management of these patients requires a clinical, laboratory and radiological assessment in order to address the underlying aetiology. There are several causes of pain, divided in joint and non-joint related, which should be diagnosed and treated promptly. Patients with unexplained pain should be treated conservatively since a plausible reason has been identified.
|
0 |
Skin grafts provide durable end-bearing coverage for lower-extremity amputations with critical soft tissue loss
|
DoD LSA (Limb Salvage vs Amputation)
|
Lower-extremity amputations in the presence of soft tissue loss represent an unresolved conundrum because surgeons must consider sacrificing bone length to obtain adequate soft tissue coverage. Local flaps and microvascular soft tissue transfers are established strategies for maintaining residual limb length. However, the use of skin grafts remains controversial due to the presumed inferiority compared with flaps with regard to enabling prosthetic fitting and full weight bearing. The current study was designed to test the hypothesis that split-thickness skin grafts represent a safe and feasible option to preserve bone length in lower-extremity amputations with critical soft tissue loss.
|
0 |
CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma
|
MSTS 2022 - Metastatic Disease of the Humerus
|
BACKGROUND: The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR).
OBJECTIVE: To investigate which baseline factors were associated with OS and ORR benefit with nivolumab versus everolimus.
DESIGN, SETTING, AND PARTICIPANTS: Subgroup OS analyses were performed using Kaplan-Meier methodology. Hazard ratios were estimated using the Cox proportional hazards model.
INTERVENTION: Nivolumab 3mg/kg every 2 wk or everolimus 10mg once daily.
RESULTS AND LIMITATIONS: The minimum follow-up was 14 mo. Baseline subgroup distributions were balanced between nivolumab and everolimus arms. Nivolumab demonstrated an OS improvement versus everolimus across subgroups, including Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium risk groups; age <65 and >=65 yr; one and two or more sites of metastases; bone, liver, and lung metastases; number of prior therapies; duration of prior therapy; and prior sunitinib, pazopanib, or interleukin-2 therapy. The benefit with nivolumab versus everolimus was noteworthy for patients with poor MSKCC risk (hazard ratio 0.48, 95% confidence interval 0.32-0.70). The mortality rate at 12 mo for all subgroups was lower with nivolumab compared with everolimus. ORR also favored nivolumab. The incidence of grade 3 or 4 treatment-related adverse events across subgroups was lower with nivolumab. Limitations include the post hoc analysis and differing sample sizes between groups.
CONCLUSION: The trend for OS and ORR benefit with nivolumab for multiple subgroups, without notable safety concerns, may help to guide treatment decisions, and further supports nivolumab as the standard of care in previously treated patients with aRCC.
PATIENT SUMMARY: We investigated the impact of demographic and pretreatment features on survival benefit and tumor response with nivolumab versus everolimus in advanced renal cell carcinoma (aRCC). Survival benefit and response were observed for multiple subgroups, supporting the use of nivolumab as a new standard of care across a broad range of patients with previously treated aRCC. The trial is registered on ClinicalTrials.gov as NCT01668784.
|
0 |
Arthroscopic debridement with continuous irrigation for septic arthritis of the shoulder joint
|
Glenohumeral Joint OA
|
Purpose: The purpose of this study was to investigate the outcome of arthroscopic debridement with continuous irrigation in patients with septic arthritis of the shoulder joint. Methods: Ten patients (four men, six women) with septic arthritis of the shoulder joint were treated with a combination of arthroscopic debridement and continuous irrigation. All patients were followed for a minimum of 4 years. The average age was 61. 7 years with a range of 25 to 86. The etiology of infection was determined to be a subacromial injection in six cases, EMG needle puncture in one, hematogenous in two, and unknown in one case. Causative bacteria, follow-up period, recurrence, shoulder pain, University of California, Los Angeles (UCLA) shoulder score, and radiographic findings were evaluated. Result: Staphylococcus aureus was cultured in six cases, and Staphylococcus epidermidis, in four cases. The average follow-up period was 103.3 months with a range of 48 to 199. The infection was eradicated completely with a single arthroscopic debridement with continuous irrigation in nine patients. One patient required a second operation. In all patients, severe pain before operation improved. The average UCLA shoulder score increased from 5.7 points prior to the operation to a post-operation score of 26.4 points. In standard radiographic findings, five cases had aggravated osteoarthritis in the affected joint. Conclusion: This study shows that arthroscopic debridement with continuous irrigation for septic arthritis of the shoulder joint improves shoulder pain, functional scores, and subjective outcome and prevents recurrence in many cases. © 2011 EFORT.
|
0 |
Knee osteoarthritis in women
|
OAK 3 - Non-arthroplasty tx of OAK
|
Osteoarthritis is a disease that progresses over time and culminates in the destruction of articular cartilage and joints. Thus, with an increasing elderly population the treatment of knee osteoarthritis has become a major healthcare issue. It has been shown that women are more severely impacted by knee osteoarthritis. Differences in knee anatomy, kinematics, previous knee injury, and hormonal influences may play a role. Sex difference with respect to osteoarthritis presentation, treatment, and the allocation of resources also exists. In general, women present for treatment in more advanced stages of osteoarthritis and have more debilitating pain than their male counterparts. In addition, healthcare providers are more likely to recommend total joint arthroplasty for their male patients. Understanding how and why these gender differences occur is instrumental in formulating an inclusive strategy for combating osteoarthritis in the future. © 2013 Springer Science+Business Media New York.
|
0 |
The influence of reading direction on hemianopic reading disorders
|
Upper Eyelid and Brow Surgery
|
UNLABELLED: Hemianopic reading impairment is a consequence of a visual field defect to either the right or the left side and is characterized by an increased reading time and reduced reading performance. Depending on the side of the visual field defect, reading will be affected differently: Patients suffering from a visual field defect to the right side have noticeable difficulties in reading fluently with slowing. Patients suffering from a visual field defect to the left usually struggle to find the beginning of a line and read more fluently. It was suggested in the literature that changing the reading direction from horizontal to vertical may be a training strategy to reduce reading problems in patients with hemianopia. The aim of the study was to investigate the influence of reading direction on reading speed in patients with left- or right-sided visual field defects and in healthy controls. METHOD: In 13 patients with hemianopia and in 13 age-matched controls, reading speed was calculated for texts in standard as well as in clockwise rotated orientation of 90, 180, and 270 degrees . RESULTS: In both groups, text rotation reduced reading speed compared to standard reading. Patients with left-sided hemianopia had the greatest reduction after text rotation. Patients with right-sided hemianopia had the smallest speed reduction in 90 degrees vertically rotated texts. CONCLUSIONS: Text rotation has different effects in left- or right-sided hemianopia patients. For patients with left-sided heminanopia, rotation of the text may not be a helpful training strategy, for right-sided hemianopia vertical rotation of the text of 90 degrees may be a beneficial training strategy to reduce reading deficits.
|
0 |
Bone Cancer: Diagnosis and Treatment Principles
|
DoD LSA (Limb Salvage vs Amputation)
|
Primary bone cancers include osteosarcoma, Ewing sarcoma, and chondrosarcoma. They account for less than 1% of diagnosed cancers each year and are associated with significant morbidity and mortality. Timely diagnosis is challenging because of late patient presentation, nonspecific symptoms that mimic common musculoskeletal injuries, and low suspicion by physicians. Plain radiography is the preferred diagnostic test. Radiographic suspicion of a bone malignancy should prompt quick referral to a cancer center for multidisciplinary care. Osteosarcoma, the most common bone cancer, most often occurs in children and adolescents. It typically develops in the metaphysis of long bones, specifically the distal femur, proximal tibia, and proximal humerus. Metastasis to the lungs is common. Use of neoadjuvant and adjuvant chemotherapy, in combination with surgery, has improved survival rates to nearly 80% for patients with localized disease, and 90% to 95% of patients do not require limb amputation. Ewing sarcoma is the second most common bone cancer and is similar to osteosarcoma in terms of presenting symptoms, age at occurrence, and treatment. Prognosis for osteosarcoma and Ewing sarcoma depends on the presence of metastasis, which lowers the five-year survival rate to 20% to 30%. Chondrosarcoma is the rarest bone cancer, primarily affecting adults older than 40 years. Survival rates are higher because most of these tumors are low-grade lesions.
|
0 |
Thompson Hemiarthroplasty for Femoral Neck Fracture Is Associated With Increased Risk of Dislocation
|
Hip Fx in the Elderly 2019
|
Background: This contemporaneous large multicenter retrospective study reflective of current practice, assesses the impact of patient factors, prosthesis selection, and implant features on the risk of dislocation after hip hemiarthroplasty for femoral neck fracture. Methods: Radiographic records for 4116 consecutive patients who underwent a hip hemiarthroplasty between January 1, 2009 and September 30, 2017 at 3 acute hospitals (including a regional major trauma center) for a neck of femur fracture were reviewed in conjunction with United Kingdom National Hip Fracture Database records. Results: In total, 4116 patients were eligible for inclusion in the study; 63 of 4116 (1.5%) dislocations were identified. Patient age, gender, preoperative abbreviated mental test score, postoperative abbreviated mental test score, and American Society of Anaesthesiologists grade were not found to be significant predictors of dislocation rates (P < .05). The Furlong prosthesis was the most commonly used implant (2280/4116, 55.4%) followed by the Exeter V40 + Unitrax head (1179/4116, 28.6%), other implants used during the study period were the monoblock Austin-Moore and Thompson implants. Hemiarthroplasty operations undertaken with the Thompson (24/273, 3.7%) were found to have significantly higher dislocation rates (P < .05). Cemented vs uncemented, variable vs fixed offset, and monoblock vs modular implant designs did not contribute to higher dislocation rates (P < .05). Surgeon seniority was also not a significant risk factor for subsequent dislocation (P < .05). Conclusions: Thompson hip hemiarthroplasties are associated with higher dislocation rates when compared to a contemporaneous cohort of implant choices and considerations for their use should be made in conjunction with this major risk factor for the need for subsequent operations.
|
0 |
Apronectomy combined with laparotomy for morbidly obese endometrial cancer patients
|
Panniculectomy & Abdominoplasty CPG
|
Background: The surgical management of morbidly (BMI >40) and super obese (BMI >50) women with endometrial cancer is challenging. The aim of this study was to describe the short and long term outcomes of apronectomy combined with laparotomy for endometrial cancer staging and tumour debulking. Methods: A retrospective case note review of morbidly obese patients undergoing combined apronectomy and laparotomy for suspected endometrial cancer between 2007 and 2009 was performed. Short term (operating time, estimated blood loss, complication rates, duration of hospital stay) and long term outcomes (weight profile over 24-month follow up period) were evaluated. Results: Twenty-one patients were identified with a median age of 58 years and a median BMI of 49 (range 37-64). Apronectomy combined with laparotomy took 192 min on average to complete, with a mean estimated blood loss of 497 ml. There were no intra-operative complications. Postoperative complications included anaemia (14% required a blood transfusion), urinary tract infection (5%) and wound complications (wound infection in 29% and partial wound dehiscence in 5%). The median post-operative stay was 9 days. At twenty-four months, one-third of patients were heavier (mean 5 kg, range 2-8 kg) but almost two-thirds of patients were considerably lighter than they had been pre-operatively (mean 13 kg lighter, range 9-17 kg). Conclusions: Apronectomy combined with laparotomy was safe and well tolerated in this group of patients. Sustained weight loss by two-thirds of the patients over the two-year follow up period may reflect lifestyle changes instigated by individual patients following surgery. Combined apronectomy and laparotomy may provide an alternative to standard surgery for this challenging group of patients. © 2011 Elsevier Ltd. All rights reserved.
|
0 |
Is avoidance of sunlight a cause of fractures of the femoral neck in elderly Saudis?
|
Management of Hip Fractures in the Elderly
|
A study of the frequency of admitted cases of femoral neck fractures to Riyadh Central Hospital, Riyadh, Saudi Arabia, showed admission of 95 patients over 40 years of age in a period of one year. The male to female ratio was 64% males to 36% females. Vitamin D nutritional status of patients with fractures of the neck of the femur expressed as 25-(OH)D3 was significantly lower (5.9 +/- 2.9 ng/ml) than of controls (9.7 +/- 4.7 ng/ml). Comparison of the housing types of both patients and controls showed that those living in traditional mud houses have significantly lower levels of 25-(OH)D3 than those occupying villas or flats. A third group of patients with low stores of vitamin D were exposed to natural ultraviolet light for a short period. This resulted in a significant increase in the levels of serum 25-(OH)D3 and a decrease in alkaline phosphatase activity. It is concluded that low levels of serum 25-(OH)D3 may play a role in the pathogenesis of femoral neck fractures in elderly Saudis and this may be due to minimal exposure to natural ultraviolet irradiation
|
0 |
Mid-term results using a cementless hip prosthesis in young Chinese patients: A five- to seven-year follow-up study
|
PJI DX Updated Search
|
A retrospective study was undertaken to evaluate the clinical and radiographic outcomes of 74 cementless total hip arthroplasties (THA) in 69 young Chinese patients. The Asian size and MMA AML stems with smoothly tapered tip were used, and the patients were followed up for at least five years. The mean Harris hip score was 45.4 preoperatively and 95.3 at the last follow-up. The incidence of thigh pain was 5.4%, and was related to the short stature of the patient (<160 cm) (P=0.030). Six patients (6 hips, 8.1%) had acetabular osteolysis in zone 2; reoperation was performed in one patient because of osteolysis and wear of the polyethylene liner. The survival rate of the metal acetabular and femoral components was 100% (95% confidence interval, 0.95-1.0). Primary THA with this AML prosthesis had an acceptable mid-term result in young Chinese patients. é 2008 Springer-Verlag
|
0 |
Intraoperative measurement of bone electrical potential: a piece in the puzzle of understanding fracture healing
|
Hip Fx in the Elderly 2019
|
INTRODUCTION: Bone electrical potentials change with the force applied. Also, fracture alters the bone electrical potential, so it becomes more electronegative. These potentials have an important role in fracture healing, bone growth and remodelling. Literature data on the influence of fracture operative treatment on bone electrical potentials, and possible consequences of this influence, are sparse. The objective of this study was to establish a method of intraoperative bone potential measurement, and to try to find a correlation between electrical potential and fracture type, osteosynthesis method and prognosis.
PATIENTS AND METHODS: 52 patients with a pertrochanteric fracture were included in the study. Bone electrical potentials were measured intraoperatively using a thin Kirschner wire introduced through bone cortex at the selected point and pointed to opposite cortex, not penetrating it. Kirschner wires were connected using clamps to multimeter (YF-78 Multimeter) device. Neutral electrode (inductive rubber) was placed behind ipsilateral gluteus.
RESULTS: Near the fracture site potentials of -199 up to -267 mV were recorded. Mean measured potential of bone plate after fixation was -240 mV. Bone potentials correlated with the subtype of fracture and early mobilisation of patients.
CONCLUSIONS: Bone potentials, caused by fracture, can be measured intraoperatively; the operative procedure appears to influence their generation. Measured potentials depend on the fracture type, and could be correlated with prognosis.
|
1 |
How effective is periarticular drug infiltration in providing pain relief and early functional outcome following total hip arthroplasty?
|
AAHKS (8) Anesthetic Infiltration
|
The aim of the study was to compare the efficacy of periarticular injection of a cocktail of analgesic drugs (PIC) with epidural infiltration (EA), in providing postoperative pain relief and early functional improvement following Total Hip Arthroplasty (THA). Methods: 50 patients undergoing unilateral THA were randomized to receive either EA or PIC for postoperative pain control. Postoperative pain relief, as determined by the visual analogue scale (VAS), functional recovery and side effects related to EA and PIC were assessed. Results: PIC resulted in significantly lower VAS scores [0.48(0.71) vs 3.04(2.07)] in the first 24 h after surgery [mean (SD)], when compared to EA. The pain relief continued to be significantly lower even on the 10th postoperative day. Functional recovery was significantly better in the PIC group, with patients being able to walk longer distances and climb steps more quickly following THA. EA, unlike PIC was associated with side effects like nausea, vomiting, motor weakness, back pain and urinary retention. The overall satisfaction rate with treatment was significantly better in PIC group (9.04/10) than those who received EA (7.76/10). Conclusion: PIC provides significantly better pain control and functional recovery in the early postoperative period, with less side effects when compared with EA. PIC should be the choice for pain control following THA.
|
0 |
Tantalum uncemented tibial component in total knee arthroplasty: Mid-term results
|
Surgical Management of Osteoarthritis of the Knee CPG
|
Introduction The porous tantalum is a very important alternative in prosthetic surgery of the knee. The purpose of this prospective study was to evaluate the clinical and radiographic results in the short and in the medium term of tantalum uncemented tibial component in total knee arthroplasty. Materials and methods In our Unit, from July 2005 to July 2011, 98 total knee arthroplasty were performed with the Nexgen LPS system (Zimmer, Warsaw, Indiana, USA) using the tibial component in cementless tantalum Trabecular Metal(trademark) with polyethylene monoblock. We have always given intra-operative indication in the use of this tibial component according to the quality of the patient's bone. In all cases the polyethylene was PS. Forty patients were female and 57 were male and their average age was 61 years (range 46-75). The average follow-up was 40 months (range 6-78). The protocol provided a clinical and radiographic evaluation preoperative after 3 months and annually, and only clinical evaluation after 1 and 6 months post-operatively. The clinical and radiographic evaluation pre-and post-surgery was performed using the Knee Society Scores. Results We didn't find any intra-operative complications. We performed 1 revision (1 %) of the component in TM due to late infection. The average score of the Knee Score increased from 40 points (28-60) pre-op. to 92 points (58-100) at last follow-up. In 97 % of the cases we obtained excellent and good results. At radiographic evaluation we didn't observe any case of periprosthetic radiolucent line greater than 1 mm, periprosthetic osteolysis and aseptic loosening of the implants. Discussion The TM is a material that has a high coefficient of friction and mechanical strength, 80 % porosity, and modulus of elasticity similar to bone; these features allow the immediate primary stability and a lasting osseointegration. Furthermore, the particular type of manufacture of this tibial component, which is a monoblock with polyethylene, is able to minimize the friction and therefore limit wear that occurs at the interface polyethylene-metal back. These features make the tantalum tibial component a valid alternative to the cemented components in selected cases. Conclusions The good clinical and radiographic results obtained, lead us to believe that the use of tantalum tibial component may be a good solution, especially for the young patient suffering from knee arthrosis, but we need longer follow-up to evaluate the percentages of long-term failure
|
0 |
The role of infrapopliteal angioplasty
|
DoD LSA (Limb Salvage vs Amputation)
|
Infrapopliteal percutaneous transluminal angioplasty (PTA) is currently indicated in patients with critical limb ischaemia (CLI). It may be performed after femoral angioplasty or bypass surgery, to improve outflow and hence patency of the proximally treated segment. Patients with CLI are typically elderly with multiple co-morbidities and limited life expectancy and therefore, a procedure, which is minimally invasive with reduced morbidity and mortality but lesser long-term patency, may be more appropriate than a more invasive procedure with better long-term patency. Clinical success is superior to angiographic patency, because once healing has occurred, should the artery restenose or occlude, collateral flow can be sufficient to preserve tissue integrity if there is no further injury. Although no prospective randomized trials have been performed, the reported limb-salvage rates of PTA are comparable with surgery. As PTA carries a lower morbidity and mortality, shorter hospital stay and does not preclude surgery, it is ideal for this group of patients who are high-risk surgical candidates. Improvements in guide-wire and catheter technology and recanalization techniques mean that very long stenoses or occlusions, and multiple lesions can be treated successfully. At the current time, PTA is the treatment of choice for infrapopliteal occlusive disease; experience with the use of stents in this territory is increasing but currently insufficient to justify their primary use.
|
0 |
Heel ulcer incidence following orthopedic surgery: a prospective, observational study
|
Management of Hip Fractures in the Elderly
|
People undergoing orthopedic surgery receive care at many points along the healthcare continuum. Although heel pressure ulcer (HPU) incidence in the orthopedic population has been reported to be 13.3%, information is limited. The purpose of this prospective observational study was to evaluate: 1) the cumulative incidence of HPUs in orthopedic patients across the continuum of care, and 2) the outcome of HPUs once they occurred. Of the 72 study participants (average age 76 +/- 16 years, 60% women, 53% required surgery for hip fractures), 57 were recruited consecutively upon admission to a rehabilitation center from one of two acute care facilities and 15 were assessed upon admission to one of the acute care sites and at discharge to the home. All but two study participants were followed-up in the community 1 month after discharge from the acute care or rehabilitation facility. Medical charts were reviewed and study participants underwent a bedside assessment, with direct examination of both heels and staging of the ulcer at admission and discharge. The cumulative incidence of HPUs was 17% (95% CI 8%-26%). All ulcers were identified upon admission to the rehabilitation center; 41% of HPUs were either suspected deep tissue injury (sDTI) or unstageable. Both of the Stage I and two of the five Stage II ulcers were resolved at the time of follow-up; three of the five sDTI or unstageable ulcers were unresolved. HPUs occurred in 17% of people undergoing orthopedic procedures. All ulcers occurred in acute care and severe ulcers persisted while patients received rehabilitation and community care. This is the first study to follow orthopedic patients across the continuum of care
|
0 |
Novel quantitative assessment of metamorphopsia in maculopathy
|
Upper Eyelid and Brow Surgery
|
PURPOSE: Patients with macular disease often report experiencing metamorphopsia (visual distortion). Although typically measured with Amsler charts, more quantitative assessments of perceived distortion are desirable to effectively monitor the presence, progression, and remediation of visual impairment. METHODS: Participants with binocular (n = 33) and monocular (n = 50) maculopathy across seven disease groups, and control participants (n = 10) with no identifiable retinal disease completed a modified Amsler grid assessment (presented on a computer screen with eye tracking to ensure fixation compliance) and two novel assessments to measure metamorphopsia in the central 5 degrees of visual field. A total of 81% (67/83) of participants completed a hyperacuity task where they aligned eight dots in the shape of a square, and 64% (32/50) of participants with monocular distortion completed a spatial alignment task using dichoptic stimuli. Ten controls completed all tasks. RESULTS: Horizontal and vertical distortion magnitudes were calculated for each of the three assessments. Distortion magnitudes were significantly higher in patients than controls in all assessments. There was no significant difference in magnitude of distortion across different macular diseases. There were no significant correlations between overall magnitude of distortion among any of the three measures and no significant correlations in localized measures of distortion. CONCLUSIONS: Three alternative quantifications of monocular spatial distortion in the central visual field generated uncorrelated estimates of visual distortion. It is therefore unlikely that metamorphopsia is caused solely by retinal displacement, but instead involves additional top-down information, knowledge about the scene, and perhaps, cortical reorganization.
|
0 |
Antimicrobial effect of a chlorhexidine-thymol varnish (Cervitec) in orthodontic patients. A prospective, randomized clinical trial
|
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
|
The aim of the present investigation was to study the effect of combined application of a fluoride varnish (Fluor Protector) and an antimicrobial varnish (Cervitec) on the oral microflora, caries and gingival condition in patients receiving treatment with fixed orthodontic appliances. A total of 198 individuals (12 to 15 years old), scheduled for fixed orthodontic treatment, were randomized into 2 groups. Prior to bonding, the Cervitec and the control group received one application with Cervitec or a placebo every week for 3 weeks, respectively. In the Cervitec group. Fluor Protector was applied at bonding and Cervitec at the next visit, 6 weeks later. Each varnish was then applied every 12 weeks for 24 weeks. In the control group, the fluoride varnish was applied only at bonding and every 12 weeks. The Visible Plaque Index (VPI), the Gingival Bleeding Index (GBI), the White Spot Lesion Index (WSL) and the level of mutans streptococci in plaque and saliva were recorded 3 weeks prior to bonding and after 24 weeks. At bonding and after 12 weeks, only VPI, GPI, plaque and salivary mutans streptococcus counts were recorded. During the 3-week prebonding period, the mean VPI, GBI and mutans streptococci in plaque decreased in both groups. At bonding, the mean level of mutans streptococci in plaque was significantly lower in the Cervitec group than in the control group. The mean level of mutans streptococci was significantly lower after 12 weeks' bonding in the Cervitec group than in the control group. No effects on the other parameters were found during the 24 weeks
|
1 |
Perioperative and Long-Term Smoking Behaviors in Cosmetic Surgery Patients
|
Panniculectomy & Abdominoplasty CPG
|
BACKGROUND: Many plastic surgeons advocate smoking cessation before patients undergo cosmetic surgery with extensive soft-tissue dissection. Smoking cessation rates after cosmetic surgery are unknown. The preoperative consultation may be an opportunity to promote long-term smoking cessation. METHODS: This is a retrospective, cross-sectional cohort study. All patients over an 8-year study period who smoked before their preoperative consultation; who quit 2 weeks before surgery; and who subsequently underwent rhytidectomy, abdominoplasty, or mastopexy were included. Patients were asked to complete a Web-based survey at long-term follow-up. RESULTS: Eighty-five smokers were included, and 47 patients completed the survey, for a response rate of 55.3 percent. Average follow-up was 63.3 months. Five respondents were social smokers and thus excluded. Of the 42 daily smokers, 17 patients (40.5 percent) were no longer smoking cigarettes on a daily basis at long-term follow-up. Of these 17 patients, 10 (23.8 percent) had not smoked since their operation. A total of 24 patients (57.1 percent) had reduced their cigarette consumption by any amount, and 70.8 percent (17 of 24) of these patients agreed that discussing adverse surgical outcomes related to smoking influenced their ability to quit/reduce. Twenty-one of 42 patients (50.0 percent) admitted that they were not compliant with the preoperative smoking cessation instructions. CONCLUSIONS: This is the first report to investigate long-term smoking cessation from a cosmetic surgery practice. The authors have shown a positive association between smoking cessation and cosmetic surgery. Requesting a period of cessation before cosmetic surgery may promote long-lasting smoking cessation.
|
0 |
Compartment elasticity measured by pressure-related ultrasound to determine patients "at risk" for compartment syndrome: an experimental in vitro study
|
DOD - Acute Comp Syndrome CPG
|
BACKGROUND: Decision-making in treatment of an acute compartment syndrome is based on clinical assessment, supported by invasive monitoring. Thus, evolving compartment syndrome may require repeated pressure measurements. In suspected cases of potential compartment syndromes clinical assessment alone seems to be unreliable. The objective of this study was to investigate the feasibility of a non-invasive application estimating whole compartmental elasticity by ultrasound, which may improve accuracy of diagnostics.
METHODS: In an in vitro model, using an artificial container simulating dimensions of the human anterior tibial compartment, intra-compartmental pressures (p) were raised subsequently up to 80 mmHg by infusion of saline solution. The compartmental depth (mm) in the cross-section view was measured before and after manual probe compression (100 mmHg) upon the surface resulting in a linear compartmental displacement (d). This was repeated at rising compartmental pressures. The resulting displacements were related to the corresponding intra-compartmental pressures simulated in our model. A hypothesized relationship between pressures related compartmental displacement and the elasticity at elevated compartment pressures was investigated.
RESULTS: With rising compartmental pressures, a non-linear, reciprocal proportional relation between the displacement (mm) and the intra-compartmental pressure (mmHg) occurred. The Pearson coefficient showed a high correlation (r(2)=-0.960). The intra-observer reliability value kappa resulted in a statistically high reliability (kappa=0.840). The inter-observer value indicated a fair reliability (kappa=0.640).
CONCLUSIONS: Our model reveals that a strong correlation between compartmental strain displacements assessed by ultrasound and the intra-compartmental pressure changes occurs. Further studies are required to prove whether this assessment is transferable to human muscle tissue. Determining the complete compartmental elasticity by ultrasound enhancement, this application may improve detection of early signs of potential compartment syndrome.
|
0 |
Verification of the median-to-ulnar and ulnar-to-median nerve motor fiber anastomosis in the forearm: An electrophysiological study
|
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
|
Objective: To estimate the real occurrence of the motor median-to-ulnar nerve anastomosis in the proximal forearm (Martin-Gruber anastomosis, MGA), as its frequency varies between 6 and 44% in the literature and to investigate the incidence of the ulnar-to-median nerve anastomosis in the distal forearm. Methods: Compound muscle action potentials (CMAP) recorded over thenar, hypothenar, and first dorsal interosseus muscle on median or ulnar nerve stimulation at wrist and elbow and collision blocks of the median and ulnar nerve were compared in a group of 50 healthy volunteers. Particular precautions were undertaken in order to avoid false positive results due to stimulus spread to the neighboring nerve. Cases of uncertain MGA were classified as either MGA or non-MGA on the basis of posterior probabilities estimated by discriminant analysis. Results: The estimated frequency of MGA was 54% using the potential comparison method and 46% using the collision technique. An ulnar-to-median nerve anastomosis was not found in any subject. Conclusions: While the MGA is very common, the ulnar-to-median nerve anastomosis is a rarity. Standard nerve conduction studies of the median nerve with CMAP recordings solely over thenar will detect less than 14% of MGA cases. (copyright) 2002 Elsevier Science Ireland Ltd. All rights reserved
|
0 |
Collagen IX in weight-bearing areas of human articular cartilage in late stages of osteoarthritis
|
Surgical Management of Osteoarthritis of the Knee CPG
|
AIM: To determine if the amounts of collagen IX mRNA and protein are higher in osteoarthritic cartilage from weight-bearing areas of the knee joint compared to non-weight bearing areas in patients with stage IV osteoarthritis (OA). METHODS: Normal and OA cartilage samples were obtained from 15 patients undergoing total knee replacement or necropsies. mRNA was measured by real time RT-PCR and proteins were detected by Western blot and localized at the light and ultrastructural level. RESULTS: Collagen IX was found throughout all cartilage layers in healthy and OA tissue. Cells deposited collagen IX in the pericellular and interterritorial matrix and a 66% higher amount of collagen IX was detected in the pericellular matrix of the weight-bearing areas adjacent to the main defect in comparison to the macroscopically intact areas. This is in line with a 3.72 times higher amount of the respective mRNA. CONCLUSION: The increased levels of collagen IX protein and its mRNAs found in the weight-bearing areas adjacent to the main cartilage defect might reflect an attempt on the part of the diseased cartilage tissue to stabilize and protect the remaining matrix of late-stage osteoarthritic cartilage from further destruction
|
0 |
Visual Dysfunction in Posterior Cortical Atrophy
|
Upper Eyelid and Brow Surgery
|
Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pathology. The aim of this review is to summarize the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed. Emphasis is given to the visual dysfunction that defines the disorder, and the classical deficits, such as simultanagnosia and visual agnosia, as well as the more recently recognized visual field defects, are reviewed, along with the evidence on their neural correlates. The latest developments on the imaging of PCA are summarized, with special attention to its role on the differential diagnosis with related conditions.
|
1 |
Do Indomethacin or Radiation for Heterotopic Ossification Prophylaxis Increase the Rates of Infection or Wound Complications after Acetabular Fracture Surgery?
|
Hip Fx in the Elderly 2019
|
Objectives:To compare the rates of infection and wound complications in patients undergoing operative fixation (ORIF) of acetabular fractures receiving heterotopic ossification (HO) prophylaxis using indomethacin or external beam radiation therapy (XRT) versus no prophylaxis.Design:Retrospective cohort.Setting:Level I trauma center.Patients:We reviewed 473 patients undergoing ORIF of acetabular fractures through posterior, combined, or extensile surgical approaches from 2012 to 2017, with a median follow-up of 13 months (0.5-77 months).Main Outcome Measurement:Rates of infection and wound complications were stratified according to their HO prophylaxis method into three groups as indomethacin, XRT, and no prophylaxis.Results:Overall, 167 patients (35.3%) received indomethacin, 104 patients (22.0%) received postoperative XRT, and 202 patients (42.7%) received no prophylactic treatment. There was no difference between the 3 groups for the risk of surgical site infection (P = 0.280). The XRT group had a significantly increased risk of noninfectious wound complications (20.2%) compared with the indomethacin group (6.6%, P = 0.002) and the no prophylaxis group (5.0%, P < 0.0001). Multivariate analysis revealed XRT remained a significant risk factor for noninfectious wound complications compared with no prophylaxis (odds ratio 5.39; 95% confidence interval 2.37-12.22; P < 0.0001).Conclusions:Although there is no difference between XRT, indomethacin, and no HO prophylaxis for the risk of surgical site infection, the use of XRT results in more than 5 times increased risk of noninfectious wound complications compared with no prophylaxis. This increased risk should be considered when contemplating XRT for HO prophylaxis in acetabular fracture patients.Level of Evidence:Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
|
0 |
Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury
|
AMP (Acute Meniscal Pathology)
|
OBJECTIVE: Excess reactive oxygen species and oxidative damage have been associated with the pathogenesis of osteoarthritis (OA). Extracellular superoxide dismutase (EC-SOD or SOD3) scavenges superoxide is the major catalytic antioxidant in joint fluid and is decreased in OA cartilage. We studied human joint fluid samples to test whether there is an association between OA and EC-SOD or other low molecular antioxidants in the joint fluid.
METHODS: Joint fluid samples were obtained from 28 subjects with severe OA undergoing arthrocentesis or knee joint replacement and compared to joint fluid from 12 subjects undergoing knee arthroscopy for chronic knee pain, meniscal tears or anterior cruciate ligament reconstruction. EC-SOD protein was assayed by enzyme-linked immunosorbent assay (ELISA). Ascorbate and urate were measured with high performance liquid chromatography (HPLC) and total nitrates by the Greiss reaction. Glutathione (GSH) and oxidized glutathione were measured using a colorimetric method. Interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) were both measured with ELISA.
RESULTS: Human joint fluid contains significant amounts of the extracellular, catalytic antioxidant EC-SOD. Joint fluid from OA subjects is characterized by significantly decreased EC-SOD levels and significant decreases in GSH, and ascorbate compared to the reference group of knee joints with pain or subacute injury but macroscopically intact cartilage. GSH and ascorbate show only an age effect with no effect from disease state on regression modeling. Urate is present in joint fluid but does not show a significant difference between groups. IL-6 and TGF-beta both show non-significant trends to increases in the arthritic subjects. There was no correlation of EC-SOD levels with IL-6 as a marker of inflammation in either the comparison group or the OA group.
CONCLUSIONS: EC-SOD, the major scavenger of reactive oxygen species (ROS) in extracellular spaces and fluids, is decreased in late stage OA joint fluid compared to fluid from injured/painful joints with intact cartilage. Injured joints may be able to increase or maintain secretion of EC-SOD but it appears that late stage OA joints fail to do so in spite of increased oxidative stress seen in the disease. Associated age related declines in GSH and ascorbate might also contribute to the development of severe OA. The net effect of these changes in joint fluid antioxidants is likely to accelerate the damaging oxidant effects on extracellular matrix stability in cartilage tissue.
|
1 |
Results and outcomes after operative treatment of high-energy tibial plafond fractures
|
DoD SSI (Surgical Site Infections)
|
BACKGROUND: The purposes of this study were to evaluate the clinical and radiographic results and the functional outcomes after operative treatment of tibial plafond fractures treated with internal or external fixation.
METHODS: A retrospective review identified 76 patients with 79 fractures (OTA 43-B or 43-C) of the tibial plafond. Their average age was 45 years. Twenty-one fractures (27%) were open, and 43 (54%) were type 43-C3. Five were type 43-B1, four were 43-B2, two were 43-B3, 15 were 43-C1, and 10 were 43-C2. Patients were treated with open reduction and internal fixation (ORIF) (n = 63) or limited open articular reduction and wire ring external fixation (EF) (n = 16). Tibial fixation was performed at a mean of 7.6 days after injury, with staged reconstruction in 56 fractures (71%). Bone graft was used initially in 32 fractures (41%). Early and late complications, secondary procedures, and radiographic evidence of post-traumatic arthritis were evaluated. Foot Function Index (FFI) and Musculoskeletal Function Assessment (MFA) questionnaires were administered.
RESULTS: Seventy-nine fractures were followed clinically and radiographically for a mean of 26 (range 24 to 38) months, and 33 patients completed outcomes questionnaires at a mean of 98 months after surgery. Early complications included two superficial wound problems and three deep infections. Late complications included two nonunions and four malunions. Thirty-one fractures (39%) developed post-traumatic arthritis. Complications occurred after six of 21 open fractures and after 11 of 43 type C3 fractures (p = 0.007). Patients treated with EF more frequently had type C3 fractures (88% versus 46%, p = 0.004) compared with patients treated with ORIF. The EF patients developed more complications (six of 16, p = 0.007) and post-traumatic arthritis (11 of 16, p = 0.01) when compared with ORIF. Patients treated with EF (88% were type C3 fractures) had lower FFI and MFA scores. The greatest impairment in outcome was noted after type C3 fractures, regardless of the method of treatment.
CONCLUSIONS: Tibial plafond fractures are difficult to manage and may have serious complications. We identified more complications, more secondary procedures, and worse outcomes in patients with articular and metaphyseal comminution (type C3). ORIF was associated with fewer complications and less post-traumatic arthritis when compared to EF, possibly reflecting a selection bias for open injuries and more severely comminuted fractures to be managed with EF. ORIF with appropriate soft tissue handling resulted in acceptable results in most patients. Severely damaged soft tissues and highly comminuted C3 fractures may be safely treated with EF. Loss of function and progression to post-traumatic arthritis are common after tibial plafond fractures. Assessment of long-term results and the efficacy of additional reconstructive procedures will refine the treatment algorithms for these fractures.
|
0 |
Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance : The screening for CKD among older people across Europe (SCOPE) study
|
Hip Fx in the Elderly 2019
|
BACKGROUND: Chronic kidney disease (CKD) is known to be associated with several co-occurring conditions. We aimed at exploring multimorbidity patterns associated with CKD, as well as the impact of physical performance and CKD severity on them in a population of older outpatients.
METHODS: Our series consisted of 2252 patients enrolled in the Screening of CKD among Older People across Europe multicenter observational study. Hypertension, stroke, transient ischemic attack, cancer, hip fracture, osteoporosis, Parkinson's disease, asthma, chronic obstructive pulmonary disease, congestive heart failure, angina, myocardial infarction, atrial fibrillation, anemia, CKD (defined as GFR < 60, < 45 or < 30 ml/min/1.73 m<sup>2</sup>), cognitive impairment, depression, hearing impairment and vision impairment were included in the analyses. Physical performance was assessed by the Short Physical Performance Battery (SPPB) and used as stratification variable. Pairs of co-occurring diseases were analyzed by logistic regression. Patterns of multimorbidity were investigated by hierarchical cluster analysis.
RESULTS: CKD was among the most frequently observed conditions and it was rarely observed without any other co-occurring disease. CKD was significantly associated with hypertension, anemia, heart failure, atrial fibrillation, myocardial infarction and hip fracture. When stratifying by SPPB, CKD was also significantly associated with vision impairment in SPPB = 5-8 group, and hearing impairment in SPPB = 0-4 group. Cluster analysis individuated two main clusters, one including CKD, hypertension and sensory impairments, and the second including all other conditions. Stratifying by SPPB, CKD contribute to a cluster including diabetes, anemia, osteoporosis, hypertension and sensory impairments in the SPPB = 0-4 group. When defining CKD as eGFR< 45 or 30 ml/min/1.73 m<sup>2</sup>, the strength of the association of CKD with hypertension, sensory impairments, osteoporosis, anemia and CHF increased together with CKD severity in pairs analysis. Severe CKD (eGFR< 30 ml/min/1.73 m<sup>2</sup>) contributed to a wide cluster including cardiovascular, respiratory and neurologic diseases, as well as osteoporosis, hip fracture and cancer.
CONCLUSIONS: CKD and its severity may contribute significantly to specific multimorbidity patterns, at least based on the cluster analysis. Physical performance as assessed by SPPB may be associated with not negligible changes in both co-occurring pairs and multimorbidity clusters.
TRIAL REGISTRATION: The SCOPE study is registered at clinicaltrials.gov ( NCT02691546 ).
|
0 |
Unusual mechanical complications of unicompartmental low contact stress mobile bearing patellofemoral arthroplasty: A cause for concern?
|
Surgical Management of Osteoarthritis of the Knee CPG
|
The Low Contact Stress Patellofemoral Arthroplasty (LCS PFA) is a newer design belonging to the second generation of inlay type implants, addressing the problems encountered in the first generation models (Lubinus & Richard's). The cemented mobile bearing metal backed patellar component in this system is "modular"; allowing interchangeable usage with either the trochlear component in a PFA or the femoral component of a total knee arthroplasty, thus obviating the need for patellar revision during conversion of PFA to TKA. The younger active patient with a PFA may exert extreme joint reaction forces on their patellar implant, rendering early loosening of the patellar implant. The endurance of this implant with repeated flexion beyond 90(degrees) is also a concern. We describe a series of three unusual mechanical failures associated with this particular design of metal backed patellar component of the unicompartmental LCS patellofemoral arthroplasty. (copyright) 2009 Elsevier B.V
|
0 |
Mechanically and electrically evoked somatosensory potentials in normal humans
|
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
|
Somatosensory potentials evoked by mechanical stimulation of the fingernail and electrical stimulation of the nerve in the finger and at the wrist were recorded by surface electrodes over: (1) the digital nerve in the index finger, (2) the median nerve at the wrist, (3) the median nerve at the axilla, (4) the brachial plexus at Erb's point, (5) the cervical cord at C2, and (6) the scalp overlying the somatosensory cortex. Nerve conduction velocities were computed for two portions of the median nerve. Conduction times along the somatosensory pathway between spinal cord and cerebral cortex were also defined. The mechanically evoked potentials had less temporal dispersion, were of lower amplitude, and occasionally consisted of fewer components than the electrically evoked potentials. Electrical stimulation of the nerve trunk at the wrist evoked some additional components not detected by the other stimulation methods. Nerve conduction velocities and conduction times were comparable among the three methods of stimulation
|
0 |
Rhodococcus equi infection in a patient with spinocellular carcinoma of unknown origin
|
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
|
A Rhodococcus equi pulmonary infection in a 63-year-old man receiving chemotherapy and radiotherapy for spinocellular carcinoma is described. The patient, a knife-grinder, was promptly treated with levofloxacin plus amikacin followed by rifampicin for 2 months, and he is still in good clinical condition after an 8-month follow-up. (copyright) 2008 SGM
|
0 |
Lateral meniscus root tear and meniscus extrusion with anterior cruciate ligament tear
|
AMP (Acute Meniscal Pathology)
|
PURPOSE: To retrospectively determine the prevalence of posterior lateral meniscus root tears (LMRTs), as depicted on magnetic resonance (MR) images, in patients with an anterior cruciate ligament (ACL) tear and to investigate the association of LMRTs with lateral meniscus extrusion and other ligament injuries.
MATERIALS AND METHODS: Institutional review board approval was obtained; informed consent was not required. This study was HIPAA compliant. MR images were obtained in 174 male and 119 female patients (mean age, 37 years; age range, 16-87 years) and retrospectively reviewed for LMRT, medial meniscus root tear (MMRT), nonroot meniscus tear, meniscus extrusion, and presence of meniscofemoral ligaments (MFLs). The chi2 and unpaired Student t tests were performed.
RESULTS: In 33 patients, 34 meniscus root tears were identified. An LMRT was present in 26 (9.8%) of 264 patients, and an MMRT was present in eight (3.0%) (P=.008). Lateral meniscus extrusion was present in six (23%) of 26 LMRTs and five (2.2%) of 231 patients with normal meniscus roots (P<.001). Complex or deep radial tears were found in three of five cases of lateral meniscus extrusion and normal root. The MFL was not observed in five (19%) of 26 studies of an LMRT. Among these 26 studies of an LMRT, lateral meniscus extrusion was identified in three (14%) of 21 cases in which the MFL was intact and in three (60%) of five cases in which the MFL was not identified (P<.03). Prevalence of an extruded meniscus was seven (88%) of eight for an MMRT and six (23%) of 26 for an LMRT (P=.001).
CONCLUSION: Prevalence of LMRTs is greater than that of MMRTs in patients with an ACL tear. LMRTs and complex and radial tears are associated with lateral meniscus extrusion; an absent MFL is more prevalent in patients with LMRTs and when the meniscus is extruded.
|
1 |
Single stage, direct to implant pre-pectoral breast reconstruction
|
Acellular Dermal Matrix
|
BACKGROUND: Given the current trends in skin preservation during mastectomy, improved biofilm reduction algorithms, and advancements in tissue bioengineering and perfusion assessment, acellular dermal matrix (ADM)-reinforced single stage, direct to implant insertion in the pre-pectoral space has become a viable alternative to two-stage expander-based, sub-pectoral reconstruction. METHODS: The authors performed a retrospective review of their pre-pectoral cases evaluating outcomes for all single stage, direct to implant procedures. Outcomes reviewed included hematoma, seroma, infection, device loss or change, animation deformity and revisional procedures such as fat grafting. The anterior tenting surgical technique is also reviewed. RESULTS: The authors have carried out 305 direct to implant pre-pectoral breast reconstructions using an anterior tenting technique with low complication rates and superior clinical and functional outcomes. The benefits of this technique include less patient discomfort, no need for postoperative expansion, virtually no subjective negative impact on upper extremity function and elimination of animation deformity. Longer-term follow-up demonstrates maintenance of the integrity and quality of the reconstructions over time. CONCLUSIONS: The authors consider single stage, pre-pectoral direct to implant breast reconstruction to be a state-of-the-art breast reconstruction technique and have found it to be safe and reproducible. This technique is their primary choice for immediate implant-based reconstruction following mastectomy.
|
1 |
An efficient and fast computer-aided method for fully automated diagnosis of meniscal tears from magnetic resonance images
|
AMP (Acute Meniscal Pathology)
|
Menisci are structures that directly affect movement, so early detection of meniscus tears also helps to prevent progressive knee disorders such as osteoarthritis. Manual segmentation of the menisci and diagnosis of the meniscal tear is a costly process in terms of time and effort for a radiologist. The aim of this study is to automatically determine the location and the type of meniscal tears that are important in the diagnosis and effective treatment of this problem. For this purpose, 29 different MR images, which were provided by Osteoarthritis Initiative (OAI), were used in the study. This study proposes a novel three-stage (preprocessing, segmentation and classification) method for fully automated classification from MR images, and shows the performance of each stage separately. At the preprocessing step, the most compact rectangular windows for the menisci were obtained from MR slices. At the segmentation step, the menisci were segmented using fuzzy clustering methods. In order to classify the segmented images and to determine meniscus tears, three different classifiers were used. The method first decides whether there are tears on menisci; if this is the case then, determines the place and type of the tears. There are no studies that classify the meniscus tears according to their types up to now in the literature. The experimental results indicate that the automated process can be completed within a time range of 3 to 4 min with a high classification performance. Hence, the suggested computer-aided diagnosis (CAD) system can be used as a decision support system for the diagnosis of meniscal tears by radiologists.
|
1 |
Long-term outcome after arthroscopic meniscal repair versus arthroscopic partial meniscectomy for traumatic meniscal tears
|
AMP (Acute Meniscal Pathology)
|
BACKGROUND: The influence of standard meniscus treatment strategies regarding osteoarthritic progress, function, and sports activity has not been estimated in a direct long-term comparison.
HYPOTHESIS: Meniscal repair compared with partial meniscectomy (partial meniscal resection) decreases osteoarthritic changes and reduces the effect on sports activity in the long-term follow-up.
STUDY DESIGN: Cohort study; Level of evidence, 3.
METHODS: Eighty-one patients with an arthroscopic meniscus shape-preserving surgery after isolated traumatic medial meniscal tear (repair: n = 42; meniscectomy: n = 39) were examined clinically (Lysholm score, Tegner score) and radiologically (Fairbank score, compared with the uninjured knee); the follow-up was divided into midterm (3.4 years; n = 35) and long term (8.8 years; n = 46). Additionally, the influences of the preoperative sports activity level and age at surgery were evaluated.
RESULTS: In the long-term follow-up, no osteoarthritic progress was detectable in 80.8% after repair compared with 40.0% after meniscectomy (P = .005) with significant benefit for the "young" subgroup (P = 0.01). The preinjury activity level was obtained in 96.2% after repair compared with 50% after meniscectomy (P = .001). The function score revealed no significant difference between these strategies (P = .114). The athletes showed a significantly reduced loss of sports activity after repair compared with the athletes after meniscectomy (P = .001).
CONCLUSION: Arthroscopic meniscal repair offers significantly improved results for isolated traumatic meniscal tears regarding the long-term follow-up in osteoarthritis prophylaxis and sports activity recovery compared with partial meniscectomy.
|
0 |
Hip fracture and venous thromboembolism in the elderly
|
Management of Hip Fractures in the Elderly
|
Venous thromboembolism (VTE), a highly prevalent vascular disorder, is frequently clinically silent, and is often difficult to diagnose. VTE consists of both deep vein thrombosis (DVT) and pulmonary embolism (PE), both of which are associated with potentially significant morbidity and mortality. With the availability of safe and effective antithrombotic therapy, the standard of medical care should be the routine use of thromboprophylaxis. The risk of developing VTE increases with advancing age, and the performance of surgery to repair a fractured hip increases this risk even more. Thus elderly hip fracture patients are always considered to be at the highest risk for developing fatal PE. Over the last decade, new anticoagulants, such as the factor Xa inhibitor fondaparinux, have been developed that specifically target individual components of the coagulation system. Fondaparinux is a selective, synthetic factor Xa inhibitor that has been shown to significantly reduce the risk of VTE versus enoxaparin in patients undergoing surgery for hip fracture. Extended (4-week) prophylaxis with fondaparinux can produce a 96% reduction in risk of DVT and an 89% reduction in risk of symptomatic VTE events relative to perioperative (1-week) prophylaxis. As the only anticoagulant approved in the United States for thromboprophylaxis in hip fracture patients, fondaparinux offers more effective prophylaxis against VTE without compromising safety
|
0 |
Acute pain assessment and pharmacological management practices for the older adult with a hip fracture: review of ED trends
|
Management of Hip Fractures in the Elderly
|
INTRODUCTION: This article examines acute pain assessment and pharmacological management in the emergency department that occurred over a period of time after the release of the new pain assessment and management compliance standards of the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) for accredited health care organizations. Data were available from that collected for a large-scale study testing a Translating Research into Practice intervention to promote use of evidence-based practices for acute pain management in older adults. METHODS: Medical records were abstracted from hospitalized older adult patients with hip fractures admitted through the emergency department (N = 1454). Records were from 12 acute care hospitals of patients receiving care in the emergency departments from 3 different periods between 2000 and 2002. Major variables examined were (1) pain assessment practices and (2) pharmacological pain treatment practices derived from an Evidence-based Guideline on Acute Pain Management in Older Adults. RESULTS: Trends over time illustrate improvements in pain assessment practices, with almost all patients having some documentation related to pain (99% in 2002), although only 54.4% had pain assessed with a numeric rating scale, 4.2% with a non-numeric rating scale (such as verbal descriptor or faces scale), and 7.4% with nonverbal pain behaviors. Thus, 34% of patients had no objective assessment of pain documented. The mean pain intensity reported remained high (6.8 to 7.2 out of 10) across the 3 periods. By the end of the study's final data collection point in 2002, only 60% of patients had any analgesic ordered, with more than half of this group (59%) having an opioid ordered. Of those administered an analgesic, more than 90% received an opioid. Practice improvements were noted over time in a decline in intramuscular opioid administration and overall meperidine administration and an increase in morphine as the opioid of choice in this setting. DISCUSSION: Pain assessment and management practices in the emergency departments showed improvements over time following the release of JCAHO standards for pain management. However, the care documented does not consistently represent best practices for all patients
|
0 |
Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome
|
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
|
OBJECTIVES: Studies in the carpal tunnel syndrome (CTS) are supported ischemia-induced changes rather than inflammation of the flexor tenosynovium. In this study, total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) in patients with CTS has been investigated. METHODS: Forty-three patients (38 female and 5 male, 81 hands in total) diagnosed as CTS after the physical examination and electrophysiological findings included in study. The mean age of patients was 43.30 +/- 10.49 years. RESULTS: Bilateral CTS in 38 (88%) patients and unilateral CTS in five patients were detected. Dominant hand was involved in all patients. The mean symptoms duration was 30.9 months (range, 5-67 months). TAS in patients with CTS was significantly lower compared with control (1.01 +/- 0.14 versus 1.11 +/- 0.20 mmol Trolox equiv./l), (P = 0.008). TOS and OSI in patients with CTS were significant higher compared with control (15.60 +/- 7.03 versus 11.86 +/- 2.18 micromol H2O2 equiv./l and 1.57 +/- 0.72 versus 1.09 +/- 0.28), (respectively P = 0.002 and <0.001). CONCLUSION: This study shows that there is a change in the oxidative stress and antioxidant defences in patients with CTS. Increased TOS and OSI and decreased TAS might be stimulate fibrosis through disturbed signaling pattern in the tenosynovium and median nerve. These processes might play a role in occurrence and progression of CTS
|
0 |
Septic arthritis and mass of knee joint ec tuberculosis
|
Surgical Management of Osteoarthritis of the Knee CPG
|
A 30 years female complained on her right knee pain and swelling since 4 years before hospitalized. Through arthrocentesis with redness of the fluid examination, it is indicated she is suffering from malignancy with septic arthritis. Pathological examination shows non specific chronical inflammatory and suspect malignancy. In culture synovial fluid examination, it indicates pseudomonas aeroginosa infection with resistant to antbiotic. Athroscopy examination shows intra synovium mass with 3 (bullet) 4 in size suspect malignancy. In pathological examination, it shows specific chronical inflammatory ec tuberculosis. The patient was given anti tuberculosis regiment and steroid. It resulted in pain and swelling decreasing. Arthroplasty will be done to the patient to improve articulatio genue damage, after at list 2 weeks of oral anti tuberculosis treatment
|
0 |
Impact of organisational changes on fracture neck of femur management
|
Management of Hip Fractures in the Elderly
|
INTRODUCTION: In 2005, University Hospitals of Leicester formed a Fracture Neck of Femur (#NOF) project group to improve care of this group of patients. SUBJECTS AND METHODS: The salient changes effected by the group were the appointment of designated orthogeriatricians, trauma co-ordinators, clinical aides, and discharge nurses. RESULTS: As a result of these measures, the number of patients going to theatre within 48 h of admission rose from 38.5% in 2005/6 to 90% in 2007/8. In-hospital mortality decreased from 16.5% in 2005/6 to 10.9% in 2007/8. The 30-day mortality dropped from 13% in 2005/6 to 10.9% in 2007/8. Hospital stay reduced from 29 days in 2005/06 to 17 days in 2007/8. CONCLUSIONS: Re-organisation of available resources has a positive impact on reducing mortality and in-hospital stay of fracture neck of femur patients
|
1 |
Improved analgesia with clonidine when added to local anesthetic during combined spinal-epidural anesthesia for hip arthroplasty: a double-blind, randomized and placebo-controlled study
|
AAHKS (8) Anesthetic Infiltration
|
BACKGROUND: The perioperative effects of intrathecal and epidural clonidine combined with local anesthetic were evaluated in 60 patients undergoing hip arthroplasty.
METHODS: This was a double-blinded study and the patients were randomized into three groups, with 20 patients in each group. All patients received spinal anesthesia with 17.5 mg of plain bupivacaine with 15 microg of clonidine (Group BC-RC) or without clonidine (Groups B-R and B-RC). Postoperatively, epidural infusion was administered in the following way: Group B-R-ropivacaine 4 mg h(-1); Groups B-RC and BC-RC: ropivacaine 4 mg h(-1) and clonidine 40 microg h(-1). Sensory block was assessed with light touch, pinprick, transcutaneous electrical stimulation at T12 and L2 dermatomes, and perception of thermal stimuli.
RESULTS: The maximal upper level of sensory block measured by pin-prick (T6-T7) did not differ between the groups while the partial sensory block for cold and warmth were increased two dermatomes above pin-prick level in the group with intrathecal clonidine compared to the other two groups (P < 0.05). Duration of anesthesia, analgesia and motor block were longer in Group BC-RC compared to Groups B-R and B-RC (P < 0.02). Postoperatively, both VAS score on movement and PCA-morphine consumption were higher in Group B-R than in Groups B-RC and BC-RC (P < 0.01). The arterial pressure and heart rate in Groups B-RC and BC-RC were significantly lower than in Group B-R at 10-24 and 15-24 h, respectively, after spinal injection.
CONCLUSION: Low-dose intrathecal clonidine provided a better quality of anesthesia and longer-lasting analgesia. Epidural clonidine-ropivacaine infusion resulted in improved postoperative analgesia but was associated with a moderate decrease in blood pressure.
|
0 |
The suture of meniscal tears in the avascular zone enforced by a collagen I/III membrane: Clinical experience over 6 years and animal experiments
|
Surgical Management of Osteoarthritis of the Knee CPG
|
Introduction: Due to the limited healing potential of meniscal tissue different efforts have been done to enhance healing of sutured meniscus. Technique and Material: The meniscus wrap technique is based on the experience with a technique developed by the senior author (RPJ) and first applied in 2003. Wrapping the meniscus with a collagen I/III matrix might create some kind of bioreactor, guiding cell ingrowth and improving suture stability. Thirty patients with tears in the red-white or white-white zone, complex tears, delayed traumatic tears with degenerative aspects, or repeat sutures, were treated with this technique. Results: After a mean follow-up of 2.5 years (range 1-5) three patients had a symptomatic failure (10%). In two of them partial meniscectomy was performed and in the other patient (a 20-year-old female with a second suture of a bucket-handle tear) a third suture combined with an unloading osteotomy was performed, which ultimately led to clinical meniscal healing. All other 27 cases (90%) were asymptomatic. Additionally, the following complications were noted: arthrofibrosis requiring mobilization under anaesthesia (one patient), saphenous nerve entrapment necessitating revision (one patient), and ACL rerupture after reconstruction and a new trauma, with the meniscus remaining intact (one patient). Results of an animal experimental study (goats) shall be reported. Conclusions: This repair enhancement technique seems to improve the chances of healing, even in unfavourable conditions. Although the evaluation did not include a second-look arthroscopy, 90% of patients remained asymptomatic after a mean follow-up of 2.5 years. Similar to fascia sheath coverage, this technique has the disadvantage of being technically demanding and timeconsuming
|
0 |
Surgical glove bacterial contamination and perforation during total hip arthroplasty implantation: when gloves should be changed
|
PJI DX Updated Search
|
INTRODUCTION: Double gloving is recommended in orthopedic surgery, notably in total hip arthroplasties (THA) to prevent contamination of the surgical site. HYPOTHESIS: Systematic glove changes during the key phases of hip prosthesis implantation reduce the frequency of occult perforations and bacterial loading of glove surfaces. PATIENTS AND METHODS: During 29 THA implantation procedures, we evaluated the bacterial contamination of the outer glove surface and its perforation rate. Contaminations were sought by placing the gloved fingertips on blood geloses (incubation, 48 h at 37 degrees C), and perforations were sought using a water test (NF EN 455-1). RESULTS: One intervention was excluded from the study because an initial contamination was detected, leaving 28 cases analyzed. Fifteen interventions (53.6%) presented contaminated geloses (26 contaminated glove changes for 3.38% of the gloves used). These contaminations were found on the gloves of all of the gloved personnel, with no distinction as to the right or left side. Thirty-eight percent of the contaminations occurred during joint reduction, whereas the other surgical stages grouped 15-26% of the contaminations (P<0.05). Twenty-nine bacteria were identified: 62% coagulase-negative staphylococci (16% of which were methicillin-resistant). Twenty-eight perforations were identified (3.5% of the gloves used), 67.8% of which were located on the operator and 64.3% on the dominant side. Eighty percent of the perforations occurred during the "surgical incision" and the "cup and stem implantation" stages (respectively, 5.0% and 5.5% of the gloves used during the surgical time) (P<0.05), without being associated with an increased risk of bacterial contamination. At the 12-month clinical follow-up, no infectious complications were found. On the gloves worn by the 20 surgical team members contaminated during these 28 surgical procedures, replacing contaminated gloves with new sterile gloves rendered all the bacteriological samples of the subsequent surgical stages negative in 16 cases (80%). DISCUSSION: Increasing the number of outer glove renewals, notably during certain surgical stages at risk for contamination (prosthesis reduction) or perforation (surgical incision/femoral cementing) can reduce the risk of contamination and perforation. The bacteria isolated suggest a cutaneous origin. Regularly changing gloves has resulted in a sterile state in 80% of cases. LEVEL OF EVIDENCE AND TYPE OF STUDY: Level III prospective diagnostic study
|
0 |
Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis
|
PJI DX Updated Search
|
BACKGROUND: Treatment of severe osteoarthritis (OA) in relatively young patients is challenging. Although successful, total knee prosthesis has a limited lifespan, with the risk of revision surgery, especially in active young patients. Knee joint distraction (KJD) provides clinical benefit and tissue structure modification at 1-year follow-up. The present study evaluates whether this benefit is preserved during the second year of follow-up. METHODS: Patients included in this study presented with end-stage knee OA and an indication for total knee replacement (TKR); they were less than 60 years old with a VAS pain >/=60 mm (n = 20). KJD was applied for 2 months (range 54-64 days) and clinical parameters assessed using the WOMAC questionnaire and VAS pain score. Changes in cartilage structure were measured using quantitative MRI, radiography, and biochemical analyses of collagen type II turnover (ELISA). RESULTS: Average follow-up was 24 (range 23-25) months. Clinical improvement compared with baseline (BL) was observed at 2-year follow-up: WOMAC improved by 74% (P < 0.001) and VAS pain decreased by 61% (P < 0.001). Cartilage thickness observed by MRI (2.35 mm (95%CI, 2.06-2.65) at BL) was significantly greater at 2-year follow-up (2.78 mm (2.50-3.09); P = 0.03). Radiographic minimum joint space width (JSW) (1.1 mm (0.5-1.7) at BL) was significantly increased at 2-year follow-up as well (1.7 mm (1.1-2.3); P = 0.03). The denuded area of subchondral bone visualized by MRI (22% (95%CI, 12.5-31.5) at BL) was significantly decreased at 2-year follow-up (8% (3.6-12.2); P = 0.004). The ratio of collagen type II synthesis over breakdown was increased at 2-year follow-up (P = 0.07). CONCLUSION: Clinical improvement by KJD treatment is sustained for at least 2 years. Cartilage repair is still present after 2 years (MRI) and the newly formed tissue continues to be mechanically resilient as shown by an increased JSW under weight-bearing conditions
|
0 |
Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients
|
BMAC (Bone Marrow Aspirate Concentrate)
|
OBJECTIVE: To investigate the effect of the synovial fluid from knee joints of rheumatoid arthritis (RA) patients with different severities of joint destruction on osteoclastogenesis and bone resorption.
METHODS: Synovial fluid was harvested from the knee joints of 59 RA patients and 37 ostcoarthritis (OA) patients. RA patients with Larsen's knee grade 1-3 were classified as mild RA (n = 30) and those with grade 4 or 5 as severe RA (n = 29). Cytokine concentrations in synovial fluid were measured by ELISA. Osteoclastogenesis was measured by tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell (MNC) formation in a co-culture of mouse osteoblastic cells and bone marrow cells, and bone resorption by 45Ca release from pre-labelled cultured neonatal mouse calvariae.
RESULTS: The synovial fluid of severe RA patients significantly stimulated TRAP-positive MNC formation and 45Ca release compared to those of mild RA and OA patients. Among the bone-resorptive cytokines fibroblast growth factor-2 (FGF-2), tumour necrosis factor alpha (TNF-alpha), interleukin-1alpha (IL-1alpha), IL-6 and soluble IL-6 receptor (sIL-6R), only FGF-2 concentration in the synovial fluid was positively correlated to Larsen's grade, and severe RA patients showed significantly higher FGF-2 concentrations than mild RA patients. Osteoclastogenesis in a co-culture system which was stimulated by the synovial fluid of severe RA patients was significantly inhibited by a neutralizing antibody against FGF-2 and this inhibition was stronger than antibodies against other cytokines.
CONCLUSION: The increase in endogenous FGF-2 levels in the synovial fluid of RA patients may play a role in the joint destruction by inducing osteoclastogenesis.
|
0 |
The comparison of two classifications for trochanteric femur fractures: the AO/ASIF classification and the Jensen classification
|
Management of Hip Fractures in the Elderly
|
This study compares the reproducibility of two classifications for trochanteric femur fractures: the Jensen classification and the AO/ASIF classification. Furthermore we evaluated the agreement on fracture stability, choice of osteosynthesis, fracture reduction and the accuracy of implant positioning. In order to calculate the inter-, and intra-observer variability 10 observers classified 50 trochanteric fractures. The inter-observer agreement of the AO/ASIF classification and the Jensen classification was kappa0.40 and kappa0.48. The kappa coefficient of the intra-observer reliability of the AO/ASIF classification was kappa0.43 and kappa0.56 for the Jensen classification. Preoperative agreement on fracture stability and type of implant showed kappa values of kappa0.39 and kappa0.65. The postoperative agreement on choice of implant, fracture reduction and position of the implant was kappa0.17, kappa0.29 and kappa0.22, respectively. Both classifications showed poor reproducibility. This study suggests that the definition of stability of trochanteric fractures remains controversial, which possibly complicates the choice of osteosynthesis
|
0 |
Dutch randomized trial comparing standard catheter-directed thrombolysis and ultrasound-accelerated thrombolysis for arterial thromboembolic infrainguinal disease (DUET)
|
DOD - Acute Comp Syndrome CPG
|
Purpose: To report the results of the Dutch randomized trial comparing standard catheter-directed and ultrasoundaccelerated thrombolysis (UST) for the treatment of arterial thromboembolic occlusions. Methods: The DUET study (controlled-trials.com; identifier ISRCTN72676102) was designed to assess whether UST can reduce therapy time significantly compared with standard thrombolysis (ST). Sixty patients (44 men; mean age 64 years) with recently (7-49 days) thrombosed infrainguinal native arteries or bypass grafts causing acute limb ischemia (Rutherford category I or IIa) were randomized to ST (n=32) or UST (n=28). The primary outcome was the duration of thrombolysis needed for uninterrupted flow (>95% thrombus lysis), with outflow through at least 1 below-the-knee artery. Continuous data are presented as means ± standard deviations. Results: Thrombolysis was significantly faster in the UST group (17.7±2.0 hours) than in the ST group (29.5±3.2 hours, p=0.009) and required significantly fewer units of urokinase (2.8±1.6�10<sup>6</sup> IU in the ST group vs. 1.8±1.0�10<sup>6</sup> IU in the UST group, p=0.01) for uninterrupted flow. Technical success was achieved in 27 (84%) patients in the ST group vs. 21 (75%) patients in the UST group (p=0.52). The combined 30-day death and severe adverse event rate was 19% in the ST group and 29% in the UST group (p=0.54). The 30-day patency rate was 82% in the ST group as compared with 71% in the UST group (p=0.35). Conclusion: Thrombolysis time was significantly reduced by UST as compared with ST in patients with recently thrombosed infrainguinal native arteries or bypass grafts.
|
0 |
The pathogenesis and significance of menisceal cysts
|
AMP (Acute Meniscal Pathology)
|
From a total of 1571 surgically excised menisci, 112 (7.1 per cent) were found by gross and microscopic examination to contain one or more cysts. All of these cysts were associated with tears, either primarily horizontal or with a horizontal component. Tracks were often demonstrable leading from the tear to the cysts, and in some cases of osteoarthritis, detritus of bone could be found in their periphery. It is concluded that the cysts are fuelled by synovial fluid. The relationship of cysts to "myxoid" change of the meniscus is discussed.
|
0 |
The impact of coronal alignment on distal radioulnar joint stability following distal radius fracture
|
Distal Radius Fractures
|
Purpose Shift of the distal fragment of a distal radius fracture (DRF) in the coronal plane (coronal shift) may compromise the contributions of the distal oblique bundle (DOB) of the interosseous membrane to distal radioulnar joint (DRUJ) stability. The purpose of the study was to test our hypothesis that coronal shift of the distal fragment would increase dorsal-volar DRUJ displacement in response to applied load. Methods A distal radius osteotomy was performed proximal to the sigmoid notch base and the ulnar styloid was cut (to simulate triangular fibrocartilage complex detachment) in 10 cadaveric specimens. A volarly placed plate was used to shift the distal radius fragment radially in 2-mm increments. A mechanical testing apparatus applied a 20 N load to the distal fragment perpendicular to the volar cortex with the forearm in neutral, 60°pronation, and 60°supination. Dorsal-volar displacement of the radius relative to the fixed ulna was measured in the control state (DRF and ulnar styloid anatomically fixed) and in 3 positions (anatomical reduction, 2-mm coronal shift, 4-mm coronal shift) with ulnar styloid displacement. The specimens were dissected post hoc to evaluate for a distinct DOB (thickness, > 0.5 mm). Dorsal-volar DRUJ displacement was compared among testing and control states using analysis of variance. Results In specimens with a distinct DOB, 2-mm coronal shift significantly increased dorsal-volar DRUJ displacement. However, there was no difference in DRUJ displacement between 4-mm coronal shift and control state. Coronal shift did not affect dorsal-volar DRUJ displacement in specimens without a distinct DOB. Conclusions In the setting of an ulnar styloid fracture, a 2-mm (but not a 4-mm) coronal shift of the DRF is associated with increased dorsal-volar DRUJ displacement in specimens with a distinct DOB, but not in specimens without a distinct DOB. Clinical relevance Awareness of the importance of coronal shift may aid in prevention of DRUJ instability associated with DRF, especially in patients with a DOB. © 2014 ASSH r Published by Elsevier, Inc. All rights reserved.
|
0 |
Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial. WHO Melanoma Programme
|
Reconstruction After Skin Cancer
|
BACKGROUND: The use of elective regional node dissection in patients with cutaneous melanoma without any clinical evidence of metastatic spread is still debated. Our aim was to evaluate the efficacy of immediate node dissection in patients with melanoma of the trunk and without clinical evidence of regional node and distant metastases. METHODS: An international multicentre randomised trial was carried out by the WHO Melanoma Programme from 1982 to 1989. The trial included only patients with a trunk melanoma 1.5 mm or more in thickness. After wide excision of primary melanoma, patients were randomised to either immediate regional node dissection or a regional node dissection delayed until appearance of regional-node metastases. FINDINGS: Of the 252 patients entered, 240 (95%) were eligible and evaluable for analysis. 122 of these were randomised to immediate node dissection. 5-year survival observed in patients who had delayed node dissection was 51.3% (95% CI 41.7-60.1) compared with 61.7% (52.0-70.1) of patients who had immediate node dissection (p=0.09). 5-year survival rate in patients with occult regional node metastases was 48.2% (28.0-65.8) and 26.6% (13.4-41.8, p=0.04) in patients in whom the regional node dissection was delayed until the time of appearance of regional node metastases. Multivariate analysis showed that routine use of immediate node dissection had no impact on survival (hazard ratio 0.72, 95% CI 0.5-1.02), whilst the status of regional nodes affected survival significantly (p=0.007). The patients with regional nodes that became clinically and histologically positive during follow-up had the poorest prognosis. INTERPRETATION: Node dissection offers increased survival in patients with node metastases only. Sentinel node biopsy may become a tool to identify patients with occult node metastases, who could then undergo node dissection.
|
0 |
Effect of zein on biodegradable inserts for the delivery of tetracycline within periodontal pockets
|
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
|
Treatment with antibiotics within the periodontal pocket against bacterial infections represents a useful and adjunctive tool to conventional therapy for healing and teeth preservation. With this function in view, an implantable, tetracycline delivery device for the treatment of periodontal disease was developed. The aim of this study was to develop biodegradable, tetracycline-loaded microparticles made of two polymers: PLGA and zein which were compressed into monolithic devices. In this polymer delivery system, the encapsulation efficiency, release characteristics, drug-polymer interaction, and antibacterial activity of loaded drug were investigated. The interaction of tetracycline with the corn protein zein was studied by nuclear magnetic resonance (NMR), Fourier transform infrared, and X-ray diffraction. The hydrophobic interaction of tetracycline with zein in the formulations was deduced from the NMR studies, whereas X-ray diffraction studies showed a new crystalline state of the drug in the presence of the protein. Zein was not denatured by preparation of inserts. Sustained release of tetracycline was obtained, and the proportion of zein in the inserts had a great impact on the drug release. Finally, an effective tetracycline release from inserts against Staphylococcus aureus was achieved over 30 days. In conclusion, the PLGA:zein delivery system described in this study was found to be effective in controlled delivery of tetracycline, and hence may be suitable for intra-pocket delivery of antimicrobial agents in the treatment of periodontitis
|
0 |
The soft tissue repair and knee arthrodesis with ilizarov method in the treatment of the open wound which is secondary to the total knee prosthesis: Case report
|
Surgical Management of Osteoarthritis of the Knee CPG
|
The total knee arthroplasty (TKA) was performed in a 68-year-old female patient who had been followed up with the diagnosis of knee osteoarthritis. The operated knee got infected during follow up. The infection became resistant and caused soft tissue necrosis and insufficiency of extensor mechanism in spite of the debridement of the wound, antibiotic treatment and insert change. As a salvage procedure, prosthesis was removed and the knee arthrodesis with external Ilizarov fixator was performed. One week after, the soft tissue defect which was secondary to necrosis was closed with a split thickness skin graft. The bones fused at the fifteenth week. The patient was able to walk without assistance and there was no evidence of infection. infected total knee arthroplasty is one of the most difficult problems that an orthopedic surgeon may encounter. A number of treatment modalities have been proposed for the infected total knee arthroplasty so far. Knee arthrodesis with external fixator might be an effective treatment option for regaining the functions and restoration alignments of extremities in the patients with severe knee arthroplasty pproblmes complicated with infection. This case report can be a good example of satisfactory outcome and an effective approach to the resistant and complicated cases of TKA with co-morbid conditions. (copyright) 2011 by Turkiye Klinikleri
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.