title
stringlengths 3
1.99k
| abstract
stringlengths 1
512
| pmid
stringlengths 6
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| abstract embedding
list | title embedding
list |
|---|---|---|---|---|
Discography as a diagnostic test for spinal pain: a systematic and narrative review.
|
studies (AHRQ and QUADAS). Specific data were then culled from these studies and tabulated. Evidence was then classified into five levels: conclusive; strong; moderate; limited; or indeterminate.Evidence is strong for the diagnostic accuracy of discography as an imaging tool. Evidence is also strong for the ability of discography to evoke pain. There is strong evidence supporting the role of discography in identifying that subset of patients with lumbar discogenic pain. There is moderate evidence supporting
|
16850074
|
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Discography as a diagnostic test for spinal pain: a systematic and narrative review.
|
the role of discography in identifying a subset of patients with cervical discogenic pain. There is limited evidence supporting the role of discography in identifying a subset of patients with thoracic discogenic pain.Discography is a useful imaging and pain evaluation tool in identifying a subset of patients with chronic spinal pain secondary to intervertebral disc disorders.
|
16850074
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] |
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.
|
Chronic refractory spinal pain poses a peculiar diagnostic challenge because of multiple putative pain sources; overlapping clinical features; and nonspecific radiologic findings. Diagnostic injection techniques are employed to isolate the source(s) of pain. Facet or zygapophysial joint pain is an example of spinal pain diagnosed by local anesthetic injections of the facet joint or its nerve supply. Diagnostic facet joint injections are expected to meet the cardinal features of a diagnostic test (i.e.; accu
|
16850075
|
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] |
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.
|
racy; safety and reproducibility). Accuracy must be compared with a "gold" or criterion standard that can confirm presence or absence of a disease. There is; however; no available gold standard; such as biopsy; to measure presence or absence of pain. Hence; there is a degree of uncertainty concerning the accuracy of diagnostic facet joint injections.To evaluate accuracy; safety and reproducibility of facet or zygapophysial joint injections in diagnosing chronic spinal pain of facet joint origin.A systematic
|
16850075
|
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] |
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.
|
review of the literature for clinical studies on efficacy and utility of facet joint/nerve injections in diagnosing spinal pain from facet joints.Relevant literature on diagnostic facet injections was identified through database searches. Excluded were abstracts; reviews; book chapters; case reports and studies based on single blocks or blocks without radiologic control. Prospective studies with placebo control; or controlled comparative local anesthetic blocks; were given priority over retrospective studi
|
16850075
|
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] |
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.
|
es. Each study was graded using AHRQ and QUADAS criteria. The level of evidence was classified as conclusive; strong; moderate; limited; or inconclusive.Available literature pointed to strong evidence for controlled comparative local anesthetic facet joint medial branch blocks in the diagnosis of neck and low back pain. There was moderate evidence in the diagnosis of pain arising from thoracic facet joints.The evidence obtained from literature review suggests that controlled comparative local anesthetic blo
|
16850075
|
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] |
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.
|
cks of facet joint nerves (medial branch or dorsal ramus) are reproducible; reasonably accurate; and safe. The sensitivity; specificity; false-positive rates; and predictive values of these diagnostic tests for neck and low back pain have been validated and reproduced in multiple studies.
|
16850075
|
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] |
A systematic review of diagnostic utility of selective nerve root blocks.
|
Transforaminal epidural injections; or selective nerve root blocks; are used for a myriad of different spinal disorders. A clear consensus on the use of selective nerve root injections as a diagnostic tool does not currently exist. Additionally; the effectiveness of this procedure as a diagnostic tool is not clear.The objective was to evaluate the accuracy of selective nerve root injections in diagnosing spinal disorders.The study involved a systematic review of diagnostic studies about selective nerve root
|
16850076
|
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0.005808031,
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0.042332318,
0.047957078,
0.02924342,
0.048410255,
0.0018393764,
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-0.06211228,
-0.032095786,
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-0.0065011294,
0.10433796,
0.05715396
] |
A systematic review of diagnostic utility of selective nerve root blocks.
|
blocks for the diagnosis of spinal pain.A systematic review of the literature for clinical studies was performed to assess the accuracy of selective nerve root injections in diagnosing spinal disorders. Methodologic quality evaluation was performed utilizing AHRQ and QUADAS criteria. The methodology of the studies was graded and the evidence was classified into five levels: conclusive; strong; moderate; limited; or indeterminate.There is limited evidence on the effectiveness of selective nerve root injecti
|
16850076
|
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] |
A systematic review of diagnostic utility of selective nerve root blocks.
|
ons as a diagnostic tool in spinal disorder. There is insufficient research into this area for strong support; but the available literature is supportive of selective nerve root injections as a diagnostic test in equivocal radicular pain. The current analysis provides moderate evidence of transforaminal epidural injections in the preoperative evaluation of patients with negative or inconclusive imaging studies.Selective nerve root injections may be helpful as a diagnostic addition in evaluating spinal disor
|
16850076
|
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] |
A systematic review of diagnostic utility of selective nerve root blocks.
|
ders with radicular features; but the role of this diagnostic test needs to be further clarified by additional research and consensus on technique.
|
16850076
|
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] |
CT guided direct transoral approach to C2 for percutaneous vertebroplasty.
|
Percutaneous vertebroplasty is a well-established procedure consisting of the percutaneous injection of a biomaterial; usually Polymethyl methacrylate (PMMA); into a vertebral body. In most cases; this procedure affords significant pain relief and strengthens the bone. Vertebroplasty is most typically performed successfully with patients with acute compression fractures.We report a case of percutaneous vertebroplasty via the transoral approach; performed with computed axial tomography (CT) scan guidance.The
|
16850077
|
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] |
CT guided direct transoral approach to C2 for percutaneous vertebroplasty.
|
procedure was performed in a 74-year-old male with a C2 vertebral body lytic lesion.This uncomplicated; minimally invasive procedure relieved the patient's pain. The transoral route is the most direct operative approach to the pathology in the upper cervical spine.When used with the CT scanner to facilitate accurate placement of the needle; the transoral approach provides a safe and precise operative approach to the upper cervical spine.
|
16850077
|
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] |
Pneumocephalus after a lumbar epidural steroid injection.
|
Lumbar epidural steroid injections are a routine therapeutic procedure provided by pain management physicians. Despite a known low morbidity; significant acute events can occur. We report a patient who developed symptoms mimicking a stroke after an epidural injection; and provide an evaluation and assessment of this patient plus other rare complications that occur with epidural injections.
|
16850078
|
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] |
Registering clinical trials.
|
nan
|
16850079
|
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] |
Informed consent in interventional spine procedures: how much do patients understand?
|
One of the most important issues that interventional physicians address during treatment is informing patients of their treatment options. Prior to beginning treatment; patients are given this information and allowed the opportunity to ask questions. Minimal qualitative information exists as to how much of this material patients retain and understand.To determine the understanding and satisfaction patients have with the information provided through the informed consent process for interventional spine proce
|
16850080
|
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-0.025627587,
0.03437425,
0.002604362,
0.012314555,
0.010290974,
0.009565414,
0.081316,
0.025893848
] |
Informed consent in interventional spine procedures: how much do patients understand?
|
dures.Prospective qualitative interview study.University-based multidisciplinary spine practice.Twenty-five consecutive patients undergoing spinal procedures who agreed to be interviewed about the informed consent process.Not applicable.Domains of concern for patients undergoing spinal procedures were determined through a qualitative interview.Primary areas of concern for patients with the informed consent process centered on their desire for more information on the procedure and its risks; expectations of
|
16850080
|
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] |
Informed consent in interventional spine procedures: how much do patients understand?
|
the procedure and benefits; and what treatments patients feel are effective. Patients had difficulty recalling the potential risks and alternatives to the procedure. The majority of patients had tried physical therapy and medications; without benefit. The most common suggestion patients gave for improving the process was to produce a video of the procedure. Common themes encountered during the interview are reviewed; with common phrases presented for each theme.Despite discussion in the office; handouts; an
|
16850080
|
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] |
Informed consent in interventional spine procedures: how much do patients understand?
|
d pre-procedure instructions; patients felt that additional sources of information would be useful to fully understand the procedure and its risks; benefits; and alternatives. Moreover; informing patients' family members may enhance comprehension of all aspects of information provided within the informed consent process about interventional spine procedures.
|
16850080
|
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] |
Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids.
|
Multiple studies have documented the incidence of illicit drug use and abuse of opioids. Over the years; several hypotheses have been proposed. Short-acting opioids such as hydrocodone are generally considered to predispose patients to poor pain management; dependency; misuse; or abuse; whereas long-acting opioids such as methadone are thought to provide sustained pain management without dependency or abuse.To evaluate and identify the prevalence of illicit drug use and prescription drug abuse or misuse in
|
16850081
|
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] |
Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids.
|
patients receiving hydrocodone or methadone.A prospective; comparative evaluation.A total of 200 patients from an interventional pain management setting; divided into two groups of 100 consecutive patients receiving either hydrocodone (Group I) or methadone (Group II) were evaluated with urine testing for illicit drug use; and/or misuse or abuse of opioids. Drug testing was carried out by Rapid Drug Screen(R).Results of this study showed that 22% (95% CI; 13% - 30%) of Group I patients receiving hydrocodone
|
16850081
|
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] |
Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids.
|
used illicit drugs as compared with 24% (95% CI; 15% - 32%) of those in Group II who were receiving methadone. The misuse or abuse of a prescription opioid was seen in 3% (95% CI; 0% - 6%) of the patients in Group I and 12% (95% CI; 5% - 18%) in Group II. In a significant proportion of patients in both groups; the drug prescribed for them was not detected on testing. The combined use of illicit drugs and misuse of prescription drugs was noted in 24% (95% CI; 15% - 32%) in Group I and 33% (95% CI; 23% - 42%
|
16850081
|
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] |
Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids.
|
) in Group II.There were no significant differences as to illicit drug use and/or misuse of opioids in patients treated with hydrocodone or methadone. These findings suggest that the use of a long acting opioid formulation by patients with chronic pain does not reduce the risk of drug abuse or improve compliance with medical therapy.
|
16850081
|
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] |
Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study.
|
Although there are many in vivo studies evaluating lumbar disc injections; no studies have described the occurrence of intravascular uptake of contrast on discography. This phenomenon; however; has been well documented for other fluoroscopically-guided; contrast-enhanced spinal injections.To document the phenomenon and incidence of intravascular uptake during fluoroscopically-guided; contrast-enhanced lumbar disc injections.A prospective; observational; community-based study.The incidence of fluoroscopicall
|
16850082
|
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0.01800963,
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0.024989694,
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0.06740291,
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0.073743574,
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0.041720532,
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0.0421468,
-0.0013961792,
-0.02930561,
-0.047741503,
0.06687008,
0.0360459
] |
Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study.
|
y-confirmed intravascular uptake of contrast material was documented in 160 patients representing a subset of individuals presenting to a small private community hospital for evaluation and treatment of lower back pain. These patients underwent fluoroscopically-guided lumbar disc injections for therapeutic and/or diagnostic purposes.A total of 280 discs from L1-2 to L5-S1 were studied. The degree of disc degeneration of the evaluated discs was scored using the Adams' scoring criteria for intervertebral disc
|
16850082
|
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] |
Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study.
|
degeneration. The incidence of intravascular uptake as well as any correlation between stage of disc degeneration and intravascular uptake was statistically evaluated. A total of 40 out of 280 discs (14.3%) demonstrated intravascular uptake. Detection of intravascular uptake usually required real-time fluoroscopy. There was no statistical correlation between the degree of disc degeneration and the incidence of intravascular uptake. No disc infections or other adverse sequelae occurred.This is the first stu
|
16850082
|
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] |
Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study.
|
dy; to our knowledge; that addresses the incidence of intravascular uptake during lumbar disc injections in patients with low back pain. The presence of intravascular uptake may have implications both clinically and diagnostically in regards to interpretation of lumbar discography and adverse events related to loss of injected medications into the vascular system.
|
16850082
|
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] |
The presence and interrater reliability of thoracic allodynia in a whiplash cohort.
|
The need exists for more definitive clinical signs indicative of abnormal central pain processing following a whiplash injury. Our observations have identified the presence of allodynia in the thoracic spine in patients with neck pain following whiplash injury. The evaluation of allodynia in the thoracic spine in a whiplash injured population may assist in the clinical diagnosis of patients believed to be suffering from central nervous system hypersensitivity.To evaluate for the presence of allodynia in a c
|
16850083
|
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] |
The presence and interrater reliability of thoracic allodynia in a whiplash cohort.
|
ohort of patients with whiplash injury.Thirty-one patients with whiplash injuries were evaluated in this prospective study for the presence of allodynia in the thoracic spine. Thoracic vertebrae were marked by the initial evaluating clinician and a Wartenberg pinwheel was utilized to identify areas of hypersensitivity in the thoracic dermatomes. Patients were instructed to give no verbal clues; so only visual clues; as determined by the clinician; were assessed. A second clinician; blinded to the initial ex
|
16850083
|
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] |
The presence and interrater reliability of thoracic allodynia in a whiplash cohort.
|
amination results; repeated the examination in the same fashion.Thoracic allodynia was identified in 70.97% of the observed population. There was a high level of agreement between observers (Kappa coefficient of agreement; 0.8039; 95% CI; 0.7465; 0.8613; P < 0.05). There was no predilection for a particular thoracic dermatome.Thoracic allodynia was identified as a common; interrater-reliable; objective physical examination finding in this whiplash cohort.
|
16850083
|
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] |
Treating radiculopathy with an indwelling epidural catheter and infusion pump.
|
For the purpose of reducing inflammation causing radiculopathy; lumbar transforaminal and interlaminar epidural injections deliver corticosteroid to the vicinity of the spinal nerve; nerve roots; and intervertebral disc. Although acceptable; the efficacy of transforaminal injections is limited and variable. An indwelling epidural catheter offers the distinct advantages of delivering greater concentrations of corticosteroid directly to the site of pathology; over an extended duration. This extended exposure
|
16850084
|
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] |
Treating radiculopathy with an indwelling epidural catheter and infusion pump.
|
to corticosteroid may benefit the site of pathology.To evaluate the safety and efficacy of corticosteroid administered through a disposable indwelling epidural catheter and infusion pump to treat pain and dysfunction caused by lumbosacral radiculopathy.A pilot investigation consisting of a prospective consecutive series of 10 patients; conducted in a specialty hospital.An indwelling epidural catheter dispensed corticosteroid into the epidural space at the suspect level of pathology. The catheter was attache
|
16850084
|
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0.034792762,
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0.02941134,
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0.03692402,
-0.03292791,
0.022205029,
-0.05727752,
0.025042264,
-0.0490189,
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0.073102094,
0.06409754
] |
Treating radiculopathy with an indwelling epidural catheter and infusion pump.
|
d to an external; lightweight; spring-pressurized; and disposable reservoir pump holding 8.0 mg dexamethasone diluted with bacteriostatic normal saline to a total volume of 72 ml. After each patient's hospital discharge; the medication was administered into the epidural space at a rate of 1 ml per hour over a 72-hour period. Follow-up at six weeks was achieved in 100% of the patients.The outcome measures; recorded at pre-treatment and six weeks post-treatment were assessed using: the Visual Analog Scale (VA
|
16850084
|
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] |
Treating radiculopathy with an indwelling epidural catheter and infusion pump.
|
S); MOS 36-Item Short-Form Health Survey (SF-36); Pain Symptoms Survey; Oswestry Disability Index; Beck Inventory; Work History Survey; Work Index; Expectations Met Survey; Activities of Daily Living Form; and the Satisfaction With Treatment Form.There was no patient morbidity or mortality associated with this treatment; and patients; on average; experienced decreased pain levels after treatment. Mean delta VAS improvement was 4.1 (SD = 2.6; R =-9.6 to +1.5). The mean percent improvement was 46.7%.Safe and
|
16850084
|
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] |
Treating radiculopathy with an indwelling epidural catheter and infusion pump.
|
effective treatment of lower extremity radiculopathy symptoms may be obtained with this new method.
|
16850084
|
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] |
The neurobiology of nociceptive and anti-nociceptive systems.
|
Pain is both a sensory event of the peripheral and central nervous systems and an experience that arises from; and reciprocally can affect processes of higher consciousness. Alterations in peripheral and central neuraxes can lead to sensitization; structural modification and long-term potentiation that can overcome modulatory influence(s) and change the non-linear adaptability of these systems to a progressively linear; pathologic state with a diverse constellation of clinical signs and symptoms. Recent pro
|
16850085
|
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] |
The neurobiology of nociceptive and anti-nociceptive systems.
|
gress in molecular biology; neurochemistry and neuroanatomy has led to significant advancement in understanding the interactive roles of these heterogeneous systems in mediating and modulating various types of pain. This review concisely provides an overview of the structure and function of these substrates. As we reach the midpoint in a decade marked by pain control and research; such knowledge is critical to further both a more comprehensive appreciation of the phenomenon that is pain; and the development
|
16850085
|
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] |
The neurobiology of nociceptive and anti-nociceptive systems.
|
of therapeutic interventions that are innovative and effective.
|
16850085
|
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] |
The diagnosis of intrathecal infusion pump system failure.
|
Ongoing informed clinical management and rational application of various tests assist in the diagnosis of intrathecal infusion pump system failure. The goal is to rapidly identify the cause of the failure with the least risk to the patient at a reasonable cost-to-benefit ratio. We offer a review of our approach to the patient with suspected intrathecal pump failure and a brief description of the most often used diagnostic tests.
|
16850086
|
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] |
The pharmacology of sedation.
|
Sedation is commonly provided for patients undergoing interventional pain management procedures. Although many pain management interventionalists have trained in anesthesiology; the use of sedatives; analgesics and hypnotics; as well as monitoring techniques; may vary considerably between practices. This review provides an update on recent advances in the pharmacology of drugs commonly used for sedation; anxiolysis and analgesia. The information should also be useful for non-anesthesiologists who provide se
|
16850087
|
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0.017549854
] |
The pharmacology of sedation.
|
dation for their patients. In addition to providing the right drug for the procedure; patient monitoring must be appropriate for the patient and the clinical circumstances. Undertaking a sedation analgesic course of therapy in support of an interventional procedure will require that patients are monitored appropriately during the course of treatment. Guidelines for monitoring patients during sedation are available.
|
16850087
|
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] |
Paraplegia following a thoracolumbar transforaminal epidural steroid injection.
|
In recent years; transforaminal epidural injections have emerged as an alternative to interlaminar and caudal epidural steroid injections. The rationale for utilizing transforaminal epidural injections has been described for diagnostic as well as therapeutic purposes. The evidence for lumbar transforaminal epidural steroid injections in managing lumbar nerve root pain is strong; whereas it is moderate in managing cervical nerve root pain. However; these techniques are also associated with rare; but catastro
|
16850088
|
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Paraplegia following a thoracolumbar transforaminal epidural steroid injection.
|
phic; neurologic complications.To present a case report describing a devastating neurologic injury following a transforaminal thoracolumbar epidural steroid injection.A 67-year-old female was referred for treatment of chest wall pain following a T-12 compression fracture. Her pain was primarily radicular in nature. She had not responded to conservative care and continued to suffer from disabling pain. A left T12-L1 transforaminal epidural steroid injection was performed using the "safe triangle" technique;
|
16850088
|
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] |
Paraplegia following a thoracolumbar transforaminal epidural steroid injection.
|
there was appropriate spread of dye that was visualized and recorded as well as a "washout" image. The injectate consisted of a 3 mL volume of 1% ropivacaine and 50 mg triamcinolone acetonide suspension. The patient experienced a rapid and complete loss of sensation and movement below the T-10 level within five minutes after the injection. An MRI initially performed six hours after the procedure was non-diagnostic but an MRI performed two days later confirmed a thoracolumbar spinal cord infarction. High dos
|
16850088
|
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Paraplegia following a thoracolumbar transforaminal epidural steroid injection.
|
e intravenous steroids provided during the course of treatment did not significantly alter her neurological deficits and she continues to be paraplegic.This case report describes vascular injury leading to an infarction of the spinal cord following a thoracolumbar transforaminal epidural steroid injection. Alternative approaches to; or alternatives means of; performing transforaminal injections should be considered to avoid devastating neurological complications.
|
16850088
|
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] |
Spinal cord stimulation for treatment of meralgia paresthetica.
|
Meralgia paresthetica is a clinical syndrome of pain; dysesthesia or both; in the anterolateral thigh. It is associated with an entrapment mononeuropathy of the lateral femoral cutaneous nerve. Diagnosis of meralgia paresthetica is typically made clinically and is based on the characteristic location of pain or dysesthesia; sensory abnormality on exam; and absence of any other neurological abnormality in the leg. The majority of patients with meralgia paresthetica respond well to conservative treatment.To p
|
16850089
|
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] |
Spinal cord stimulation for treatment of meralgia paresthetica.
|
resent a case of intractable meralgia paresthetica in which conservative treatment options failed but which was successfully treated with a spinal cord stimulator.A 44-year-old woman presented to the pain clinic with a one-year history of bilateral anterolateral thigh pain. History; physical exam; and diagnostic work-up were consistent with meralgia paresthetica. Multiple medications; physical therapy; and chiropractic therapy were not successful for this patient. In addition; local anesthetic/steroid injec
|
16850089
|
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] |
Spinal cord stimulation for treatment of meralgia paresthetica.
|
tion of the lateral femoral cutaneous nerve provided only short-term relief. Ultimately; a spinal cord stimulator was implanted after a successful temporary percutaneous trial. Two months after the implantation; she continued to have 100% pain relief; worked full-time; was physically active; and no longer required any pain medication including opioids.An implanted spinal cord stimulator may be an ideal treatment for intractable meralgia paresthetica after conservative treatments have failed because it is no
|
16850089
|
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] |
Spinal cord stimulation for treatment of meralgia paresthetica.
|
t destructive and can always be explanted without significant permanent adverse effects.
|
16850089
|
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] |
Post-lumbar surgery complex regional pain syndrome.
|
This case report identifies a patient with complex regional pain syndrome Type 2 (causalgia) with sympathetically maintained pain in a distal extremity associated with an anterior sacroiliac fusion with local bone graft.A sacroiliac fusion was undertaken due to chronic back pain that was temporarily relieved with percutaneous injections to the joint space and lower lumber facets. A 65 year-old man underwent a left sacroliac arthrodesis for continued lumbosacral pain. The successful surgery with allograft ha
|
16850090
|
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] |
Post-lumbar surgery complex regional pain syndrome.
|
d no intraoperative complications. The patient remained in the hospital post-operatively for four days with no complications. Four to six weeks post-operative; the patient began to have swelling and pain at the ipsilateral foot. The pain progressed with evidence of allodynia; hyperesthesia; and dystrophic changes in the foot. EMG and a nerve conduction study showed severe denervation that involved not only the muscles below the knee but the quadriceps as well; and also had ongoing irritability of a number o
|
16850090
|
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] |
Post-lumbar surgery complex regional pain syndrome.
|
f muscles; including those innervated by the femoral; sciatic; and gluteal nerves in the left leg. A diagnosis of complex regional pain syndrome Type 2 (causalgia) was made with the aid of a bone scan. A series of two diagnostic percutaneous chemical sympathectomies were undertaken; and the pain was significantly relieved. This suggested complex regional pain syndrome Type 2 with sympathetically maintained pain. The patient underwent aggressive physical therapy during his rehabilitation and subsequent resol
|
16850090
|
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] |
Post-lumbar surgery complex regional pain syndrome.
|
ution of the pain syndrome occurred.Complex regional pain syndrome Type 2 with sympathetically maintained pain is a condition that can result in serious disability and can be associated with spinal procedures and sacroiliac arthrodesis. Early intervention is recommended to provide long-term resolution of the condition.
|
16850090
|
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] |
The practice of cervical transforaminal injection of steroids deserves more scrutiny.
|
nan
|
16850091
|
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] |
Tissue-engineered temporary wound coverings. Important options for the clinician.
|
Finding an ideal temporary wound dressing is challenging. Although TransCyte; built on Biobrane; offers many of the characteristics of the ideal wound dressing; and may have added benefits from the delivery of extra-cellular matrix (ECM) and growth factors to the wound; the downside of high cost and less convenient storage and usage are considerable barriers to its broader adoption. The low cost and established clinical utility of Biobrane sets the bar high for new products.
|
16850093
|
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] |
Oral lichen planus and hepatitis C virus: is there real association?
|
Lichen planus is an inflammatory; mucocutaneous disease that in addition to the skin involves oral mucosa in about 60-70 % of cases. In recent years; several reports have supposed a relationship between oral lichen planus (OLP) and chronic liver disease; especially hepatitis C (HCV). Here we present an extensive review of the literature in English that examines the association between HCV and OLP.
|
16850094
|
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0.03214453,
0.03294216,
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0.073009826,
0.041184347
] |
Blood transfusion and dermatology.
|
Blood transfusion is an accepted therapeutic procedure in all specialties of medicine. In dermatology; specialized techniques like plasmapheresis and extracorporeal photochemotherapy have provided a good treatment option in immune-mediated disorders like bullous dermatoses; collagen vascular diseases and cutaneous lymphomas. Other anecdotal and less substantiated reports point to its use in chronic disorders like atopic dermatitis and psoriasis. Untoward dermatological manifestations include mainly purpuric
|
16850095
|
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] |
Blood transfusion and dermatology.
|
rash and GVHD. Since planned studies may not be possible; pertinent observations from chance situations on the effect of blood transfusion in dermatoses would add valuable information.
|
16850095
|
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] |
Acute alopecia totalis.
|
From a group of 1;189 AA patients seen in our dermatology unit; thirteen (3 males; 10 females) experienced hair shedding that started profusely and diffusely over the entire scalp. They were under observation for about 5 years; histopathology and trichograms being performed in all instances. The mean age of the patients was 26.7 years. It took only 2.3 months on average from the onset of hair shedding to total denudation of the scalp. The trichogram at the time of diffuse shedding showed that about 80% had
|
16850096
|
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] |
Acute alopecia totalis.
|
dystrophic roots and the remaining 20% had telogen roots. Histopathological findings and exclamation mark hairs were compatible with alopecia areata. Regrowth of hair was noted 3.2 month after the onset of hair shedding and recovery observed in 4.8 months. All patients were treated by methylprednisolone pulse therapy. During the follow-up period; 53 months on average after recovery; 8 of the 13 patients (61.5%) showed normal scalp hair without recurrence; in 4 patients the recovery was cosmetically acceptab
|
16850096
|
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] |
Acute alopecia totalis.
|
le in spite of focal recurrences and only 1 patient showed a severe relapse after recovery. Considering all of the above findings; this group of the patients should be delineated by the term acute alopecia totalis.
|
16850096
|
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] |
Epidemiology of syphilis in pregnant women and congenital syphilis in Belarus.
|
In Belarus the spread of syphilis has been on the increase since 1988; and the incidence reached its peak in 1996 with 209.7 cases per 100 000 inhabitants. During the following years the incidence has reduced; but still remains high with 41 cases in 2004. In the years 1996-2004 all together 4239 pregnant women infected with syphilis were registered in Dermatovenereological Dispensaries in Belarus; giving birth to 116 children with congenital syphilis. The social end economic background of these events is re
|
16850097
|
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Epidemiology of syphilis in pregnant women and congenital syphilis in Belarus.
|
viewed.
|
16850097
|
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] |
Dermatomyositis: immunopathologic study of skin lesions.
|
The pathogenesis of the inflammatory processes in the skin of dermatomyositis patients remains unclear. The aim of this study was to investigate the patterns of proliferation and apoptosis of epidermal keratinocytes and dermal infiltrating cells in DM patients.Seventeen skin biopsy specimens from patients with dermatomyositis; which fulfilled the diagnostic criteria of Bohan and Peter; and Euwer and Sontheimer; were immunohistochemically investigated with monoclonal antibodies against human Ki-67; Bcl-2; CD
|
16850099
|
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0.054612197,
0.0162454,
0.05051761,
-0.019768339,
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0.0620569,
0.03581433
] |
Dermatomyositis: immunopathologic study of skin lesions.
|
3; CD4; anti-CD 45RO and a reaction was detected by streptovidine-biotin complex (Uni-Pak ABC).The lesional skin showed a marked increase of Ki-67-positive keratinocytes; which were predominantly located in the basal and germinative layer; but a lack of cells in areas of vacuolar degeneration and epidermal atrophy. A drastic reduction in the number of Bcl-2-positive cells localized in the basal cell compartment was observed. Antigen activated T lymphocytes (CD 45RO+) and CD3+ cells were in higher prevalence
|
16850099
|
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] |
Dermatomyositis: immunopathologic study of skin lesions.
|
in dermal perivascular infiltrates of the affected skin.The defective regulation of apoptosis may play an important role in the development of cutaneous lesions of patients with dermatomyositis; in which the skin is a prominent target organ. Abnormal expression of Ki-67 and diminution of Bcl-2 in the epidermis; coupled with the perivascular location of T cells in the dermis are crucial keys to the histological diagnosis of dermatomyositis.
|
16850099
|
[
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] |
Myoid differentiation and EMA expression in fibrosarcomatous dermatofibrosarcoma protuberans.
|
Dermatofibrosarcoma protuberans (DFSP) is a relatively unusual; locally aggressive cutaneous tumor of intermediate malignancy. Fibrosarcomatous DFSP (FS-DFSP); a rare variant of DFSP; has a higher tendency for recurrence and metastasis. Recently; a small number of cases of another variant of FSDFSB characterized by areas of myoid differentiation have been reported. We present here a 35 yearold female patient with myoid differentiation in FS-DFSP. The tumor on the left scapular region had slowly grown over s
|
16850098
|
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] |
Myoid differentiation and EMA expression in fibrosarcomatous dermatofibrosarcoma protuberans.
|
ix years. Examination revealed a domeshaped; firm; nontender; violaceous dermal nodule. Histologically; it was composed of a monotonous spindle cell population arranged predominantly in a storiform pattern and to a lesser extent in a fascicular fibrosarcomatous pattern with a parallel arrangement of the cells. Immunohistochemically; the tumor cells showed diffuse expression for vimentin and CD34. In the center of the tumor areas with frequent mitosis; hypercellular and negative reactive for CD34 were seen.
|
16850098
|
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] |
Myoid differentiation and EMA expression in fibrosarcomatous dermatofibrosarcoma protuberans.
|
In addition; approximately 10% of the cells were positive for epithelial membrane antigen. Myoid differentiation was found around the blood vessels. The myoid areas were positive for smooth muscle actin and negative for desmin. It is possible that the presence of hyperplastic myofibroblasts is a reactive phenomenon to the proliferation of tumor cells. We believe that this finding around blood vessels may be present in DFSP or FS-DFSP. However; when myoid areas; myoid fascicles and myoid nodules are seen in
|
16850098
|
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] |
Myoid differentiation and EMA expression in fibrosarcomatous dermatofibrosarcoma protuberans.
|
the stroma; it may be a new morphological variant of DFSP and/or FS-DFSP.
|
16850098
|
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] |
Dermatitis herpetiformis presenting as intertriginous dermatitis.
|
A 54-year old man with atypical dermatitis herpetiformis Duhring lasting about three years is reported. The lesions were located exclusively in the pubic area; groins; inner thighs and perianal regions. Routine histopathology and the direct as well as the indirect immunofluorescence supported the diagnosis. Application of a gluten-free diet and dapsone alleviated the symptoms.
|
16850100
|
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] |
The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity.
|
Pilomyxoid astrocytoma (PMA) is a rare glioma that shares histopathological similarities with pilocytic astrocytoma (PA). Yet; typical examples of both can be distinguished on clinical and histological grounds. The reported aggressive behavior of PMA provides a rationale for distinguishing this entity from typical PA. We report a 6(1/2) -year-old girl who had suffered poor weight gain; irritability and progressively worsening abnormal eye movements since approximately 2 months of age. Radiographic studies a
|
16850101
|
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] |
The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity.
|
t 6 months of age (age at initial presentation) revealed a large hypothalamic lesion occupying proximal portions of the optic nerves; chiasm and right posterior optic tract. The first biopsy obtained after two chemotherapy regimens was consistent with a diagnosis of PMA. The patient suffered multiple recurrences; and underwent three subsequent surgical procedures. The last two surgical specimens revealed a tumor with histopathological features of PA. She is alive with residual disease 6 years after initial
|
16850101
|
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] |
The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity.
|
presentation. While earlier studies focused on the similarities between PA and PMA; considering the latter as the "infantile" form of the former; subsequent work outlined their histological and clinical differences. Some even suggested a different cell type; such as the tanycytic cell as the origin for PMA. This report provides evidence in favor of the earlier argument that there is a close relationship between PA and PMA; and presents a rare "maturation" phenomenon; at least from a morphological perspectiv
|
16850101
|
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] |
The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity.
|
e. More systematic review of such cases will provide a better answer for the origin of PMA; and its relation to PA.
|
16850101
|
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] |
Perineural spread of malignant mesothelioma resulting in an intradural spinal cord mass: case report.
|
Spinal cord involvement by perineural spread of malignant mesothelioma is rare. We report a case of malignant mesothelioma that spread locally to invade the bony spine with both extradural and intradural perineural spread into the spinal canal that resulted in spinal cord compression. A 61-year-old man with a history of malignant mesothelioma presented with progressive leg weakness and right-sided arm weakness. Magnetic resonance imaging showed an enhancing lesion in the apex of the right lung with extensio
|
16850102
|
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] |
Perineural spread of malignant mesothelioma resulting in an intradural spinal cord mass: case report.
|
n through the C7-T1 foramina with right hemicord enhancement. The patient underwent a C7-T1 laminectomy and right-sided C7-T1 and T1-T2 foraminotomies for neural decompression and biopsy of the lesion. Intraoperatively; tumor extended epidurally; and intradural perineural tumor spread along the C8 and T1 nerve roots into the spinal cord. Because it adhered to the spinal cord; no dissectible plane could be identified that would allow for safe total removal of the tumor. The epidural portion of the tumor; the
|
16850102
|
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] |
Perineural spread of malignant mesothelioma resulting in an intradural spinal cord mass: case report.
|
adjacent involved bone; and the T1 nerve root were resected. Pathologic examination revealed malignant mesothelioma with bony invasion and perineural spread along the T1 nerve root. After decompression of the spinal cord; the patient had moderate improvement of his hand and leg function. Perineural spread of malignant mesothelioma resulting in spinal cord compression is an unusual clinical presentation. Intimate involvement of the spinal cord may prohibit aggressive tumor resection.
|
16850102
|
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] |
Cognitive functions in low-grade gliomas: disease and treatment effects.
|
The role of radiotherapy and chemotherapy in the treatment of low-grade gliomas (LGG) is controversial regarding their effect on survival and the development of neurotoxicity. The few published studies examining adverse treatment effects on cognition revealed conflicting results.To assess cognitive functioning in LGG patients who received conformal radiation therapy (RT); chemotherapy; or no treatment.40 LGG patients participated in the study; 16 patients had RT +/- chemotherapy; and 24 patients had no trea
|
16850104
|
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] |
Cognitive functions in low-grade gliomas: disease and treatment effects.
|
tment. All patients underwent a neuropsychological evaluation. APOE genotype was obtained in 36 patients who were classified in two groups based on the presence or absence of at least one apolipoprotein E small je; Ukrainian-4 (APOE small je; Ukrainian-4) allele.Treated LGG patients had lower scores than untreated patients on several cognitive domains; patients who completed treatment at intervals greater than 3 years and had long disease duration had significantly lower scores on the Non-Verbal Memory doma
|
16850104
|
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] |
Cognitive functions in low-grade gliomas: disease and treatment effects.
|
in. Antiepileptic polytherapy; treatment history; and disease duration jointly contributed to low Psychomotor domain scores. 62% of treated patients showed white matter confluence on MRI; whereas only 9% of the untreated patients had such changes. Preliminary comparisons between APOE small je; Ukrainian-4 carriers (n = 9) and non-carriers (n = 27) on cognitive domain scores revealed no statistically significant differences; but APOE small je; Ukrainian-4 carriers had lower mean scores on the Verbal Memory d
|
16850104
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] |
Cognitive functions in low-grade gliomas: disease and treatment effects.
|
omain than did non-small je; Ukrainian-4 carriers.RT +/- chemotherapy; disease duration; and antiepileptic treatment contributed to mild cognitive difficulties in LGG patients.
|
16850104
|
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] |
Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.
|
Meningiomas that arise in the sphenoid region (MSR) often display growth patterns leading to widespread invasion and destruction of the surrounding structures. Consequently; there is still estimated recurrence rate up to 30% with MSR. Conventional cytogenetic studies have failed to reveal aberrations characteristic of invasive meningiomas. Here we investigated 10 invasive and 5 non-invasive MSR using the array-based comparative genomic hybridization (array-CGH) with the GenoSensor Array 300. Mean number of
|
16850103
|
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] |
Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.
|
aberrations detected per tumor was significantly greater for invasive meningiomas-67.4 compared with 40.5 for non-invasive MSR. Additionally; invasive MSR disclosed frequent losses on 1p; 6q; 14q and gains on 15q and 20; which were identified previously as molecular hallmarks of stepwise meningioma progression. Thus; the presence of a complex cytogenetic profile and progression-associated chromosomal aberrations in benign MSR is associated with their increased invasive potential. Inasmuch as no reliable adj
|
16850103
|
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] |
Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region.
|
uvant therapy for recurrent meningiomas is available thus far; revealed genomic aberrations can provide a potential targets for drug discovery and therapeutic intervention in a future.
|
16850103
|
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] |
Independent motile microplast formation correlates with glioma cell invasiveness.
|
Diffuse brain invasion contributes to the poor prognosis for patients with gliomas. Analyzing glioma cell migration in vitro; we have demonstrated the spontaneous shedding of anucleate cell fragments that separate from glioma cell bodies and maintain viability from hours to days. Unlike previously described cell fragments that are released from cells as diffusible vectors; glioma cell fragments are independently motile. We used computerized time-lapse microscopy to characterize the formation of these indepe
|
16850105
|
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] |
Independent motile microplast formation correlates with glioma cell invasiveness.
|
ndent motile microplasts (IMMPs) in human cell cultures derived from the most highly invasive glial tumor; glioblastoma. IMMPs were larger than previously described cell fragments; ranging in size from approximately 2% to nearly half of the area of their parent cells. Complex cell-like behaviors-including establishment of polarity; extension of lamellipodia and filopodia; and change in direction of movement-remained intact in IMMPs. The average direction and velocity of the IMMPs were indistinguishable from
|
16850105
|
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] |
Independent motile microplast formation correlates with glioma cell invasiveness.
|
those of their parent cells. IMMPs formed at a significantly higher rate in glioma cell lines rendered more invasive by overexpression of invasion-related genes than in vector-transfected controls. The correlation with cell invasiveness indicates that IMMP formation may be related to the cell-invasive phenotype. Further investigation will determine whether IMMPs represent a novel addition to the growing list of viable cell fragments with biological relevance.
|
16850105
|
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] |
The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas.
|
Meningiomas are common brain tumors with somatostatin receptors that bind octreotide. We report the use of (111)indium-octreotide brain scintigraphy (OBS) for the non-invasive differentiation of meningiomas from other cranial dural-based pathology.A retrospective analysis of our experience with OBS for non-invasive identification of meningiomas was performed. Two neuroradiologists; blinded to clinical data; utilized a standardized grading scheme to define the uptake of octreotide at 6 and 24 h post-administ
|
16850106
|
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] |
The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas.
|
ration. The correlation between (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET); magnetic resonance imaging (MRI) scans; and octreotide uptake was assessed.The cohort consisted of 50 patients having a mean age of 62.4 years and a median follow-up time of 24 months. Management consisted of biopsy (n = 4); resection (n = 10); observation (n = 16); radiosurgery (n = 21); and external beam radiotherapy (n = 3). OBS was correlated with MRI (n = 50); FDG-PET brain studies (n = 38); histolog
|
16850106
|
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] |
The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas.
|
y (n = 14); and angiography (n = 1). In cases where definitive diagnosis could be made; the sensitivity; specificity; positive and negative predictor values for OBS alone were 100; 50; 75; and 100; respectively. OBS provided false positive data in 3 patients (metastasis; chronic inflammation; lymphoma). Use of OBS with MRI to differentiate meningiomas from other lesions was highly significant (P < 0.001). FDG-PET correctly identified malignant pathology with 100% sensitivity and specificity.OBS may increase
|
16850106
|
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] |
The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas.
|
the diagnostic specificity of conventional MRI when differentiating meningioma from other dural-based pathologies; while the addition of FDG-PET differentiates benign from malignant lesions.
|
16850106
|
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] |
Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells.
|
Matrix Metalloproteinases (MMPs) play a crucial role in breast cancer metastasis. We examined the mRNA and protein expression of several MMPs in brain- and bone-seeking clones of MDA-MB-231 breast cancer cells; their transcriptional regulation and their functional role in the metastatic process. MMP mRNA expression was examined using real-time reverse transcription polymerase chain reaction. Protein expression was examined using enzyme linked immunosorbent essay (ELISA). The inducibility of mRNA and protein
|
16850107
|
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] |
Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells.
|
expression was tested with TPA (phorbol 12-myristate 13-acetate; 50 microM); epidermal growth factor and transforming growth factor beta (20 ng/ml both). Migration and invasion assays were performed with the QCM 96-Well Migration/Invasion Assay (8 microm; Chemicon) over 24 h with or without specific MMPs inhibitors (MMP Inhibitor I Mix (5 microM); MMP-2/MMP-9 Inhibitor III (50 microM); EMD Biosciences). We found significantly higher mRNA expression of MMP-1 and -9 in brain-seeking 231-clones in comparison
|
16850107
|
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] |
Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells.
|
to -bone and -parental cells. In contrast; the mRNA expression of MMP-3 and -14 was comparable in all cells lines examined and MMP-13 expression was lower in both selective metastatic lines. MMP-2 and -8 were not expressed. ELISA revealed a higher amount of total as well as active MMP-1 and -9 in brain-seeking cells. TPA stimulation showed that MMP-1 and -9 transcription was inducible on the mRNA and protein level in 231-parental but not in 231-brain or -bone. 231-brain showed the highest migration and inva
|
16850107
|
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] |
Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells.
|
sive capacity which could be decreased by the application of MMP-1 and/or MMP-9 inhibitor. Our results indicate functional importance of MMP-1 and -9 overexpression in brain metastasis in an in vitro model.
|
16850107
|
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] |
Paraneoplastic motor neuropathy and inflammatory myopathy associated with nasopharyngeal carcinoma.
|
nan
|
16850108
|
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Images in neuro-oncology: anaplastic pleomorphic xanthoastrocytoma.
|
nan
|
16850109
|
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] |
Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease: a case study and review of the literature.
|
The diagnosis of sarcomatous transformation of plexiform neurofibromas in Neurofibromatosis-1 (NF 1) is a clinical and radiological challenge. Considerable overlap exists in the clinical and the radiological characteristics between the benign enlarging neurofibromas and their counterparts undergoing malignant changes. Surgical biopsy to rule out suspicious malignant transformation is often a problem in deep seated lesions.We; in this paper; explore the clinical utility of FDG-PET in detecting and assessing
|
16850110
|
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] |
Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease: a case study and review of the literature.
|
this life threatening complication of neurofibromas. A case is described with FDG-PET and MRI documentation of such transformation and subsequent histopathological correlation. The case upholds the potential advantages of a FDG-PET over the conventional imaging modalities. A review of the existing literature is also carried out; a total of four published reports on this issue were identified in English literature by searches of Pubmed.FDG-PET appeared a reliable as well as sensitive noninvasive technique th
|
16850110
|
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