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NIFD_1_S_0185_MR_T1_mprage_S3_DIS3D_br_raw_20140908135239584_61_S229140_I441470

On a T1-weighted brain MRI of a 54-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0218_MR_T1_mprage_S3_DIS3D_br_raw_20140908131021468_157_S230417_I443026

On a T1-weighted brain MRI of a 53-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of parietal lobe on angular gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild enlargement of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_073_S_4552_MR_MPRAGE_br_raw_20120215154934047_48_S140944_I285080

On a T1-weighted brain MRI of a 64-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on opercular inf. frontal gyrus (moderate) and triangular inf. frontal gyrus (mild) - mild focal atrophy of occipital lobe on middle occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_013_S_4616_MR_MPRAGE_br_raw_20120423114244289_9_S148118_I300089

On a T1-weighted brain MRI of a 85-year-old male subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (mild), frontal operculum (mild) and posterior insula (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - mild bilateral atrophy of the thalamus - moderate left atrophy of the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0267_MR_t1_mprage__br_raw_20160902213643779_41_S496356_I772611

On a T1-weighted brain MRI of a 67-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0264_MR_t1_mprage__br_raw_20160902204620868_5_S496270_I772517

On a T1-weighted brain MRI of a 60-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_153_S_4125_MR_MPRAGE_br_raw_20110720110937386_57_S115446_I245820

On a T1-weighted brain MRI of a 76-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0190_MR_T1_mprage_S3_DIS3D_br_raw_20170816151005927_150_S596443_I889392

On a T1-weighted brain MRI of a 53-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on posterior orbital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0162_MR_T1_mprage_S3_DIS3D_br_raw_20140701124018436_69_S223836_I433911

On a T1-weighted brain MRI of a 67-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - moderate bilateral atrophy of the basal forebrain - mild atrophy of the ventral dc - mild atrophy of the pallidum - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - mild right atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_003_S_4900_MR_Accelerated_SAG_IR-SPGR__br_raw_20130702111838357_9_S162272_I325733

On a T1-weighted brain MRI of a 60-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0265_MR_T1_mprage_S3_DIS3D_br_raw_20170815145928316_20_S595662_I888373

On a T1-weighted brain MRI of a 67-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on medial frontal cortex (moderate) and lateral orbital gyrus (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild right atrophy of the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_003_S_4839_MR_Accelerated_SAG_IR-SPGR__br_raw_20120729220509538_106_S158755_I319400

On a T1-weighted brain MRI of a 66-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of limbic cortex on posterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - mild right atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_072_S_4103_MR_MPRAGE_br_raw_20110721105250665_38_S115543_I245969

On a T1-weighted brain MRI of a 72-year-old male subject, we observed: For the cerebral cortex: - mild atrophy of the parietal lobe, more pronounced on the left - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the accumbens, more pronounced on the right - no evidence of atrophy in the pallidum - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0234_MR_t1_mprage__br_raw_20170814174829946_20_S594393_I886861

On a T1-weighted brain MRI of a 63-year-old female subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_094_S_4460_MR_Accelerated_SAG_IR-SPGR__br_raw_20120209083837573_192_S140247_I283576

On a T1-weighted brain MRI of a 67-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild right atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_100_S_4469_MR_MPRAGE_br_raw_20120309113839177_24_S143466_I289564

On a T1-weighted brain MRI of a 67-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - moderate bilateral atrophy of the basal forebrain, more pronounced on the right - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_022_S_4173_MR_MPRAGE_br_raw_20110914160652081_58_S122033_I255992

On a T1-weighted brain MRI of a 70-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_022_S_4291_MR_MPRAGE_br_raw_20111130090916449_95_S131264_I269153

On a T1-weighted brain MRI of a 76-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on sup. frontal gyrus - atrophies of temporal lobe on planum temporale (mild) and sup. temporal gyrus (mild) - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of occipital lobe on occipital pole - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the limbic cortex For subcortical structures: - mild right atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - moderate bilateral enlargement of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0217_MR_T1_mprage_S3_DIS3D_br_raw_20170817134937636_129_S598229_I891831

On a T1-weighted brain MRI of a 56-year-old male subject, we observed: For the cerebral cortex: - mild atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (mild) - atrophies of frontal lobe on orbital inf. frontal gyrus (mild) and posterior orbital gyrus (mild) - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_041_S_4083_MR_MPRAGE_br_raw_20110623121515278_33_S112344_I241375

On a T1-weighted brain MRI of a 86-year-old male subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: sup. frontal gyrus (moderate), triangular inf. frontal gyrus (mild) and sup. frontal gyrus medial segment (mild) - mild focal atrophy of temporal lobe on planum polare - moderate focal atrophy of occipital lobe on cuneus - mild focal atrophy of limbic cortex on middle cingulate gyrus - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the parietal lobe For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0045_MR_t1_mprage_S3_DIS3D_br_raw_20110718072112237_47_S115028_I245220

On a T1-weighted brain MRI of a 59-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0311_MR_T1_mprage_S3_DIS3D_br_raw_20160909141022230_61_S498005_I774570

On a T1-weighted brain MRI of a 75-year-old male subject, we observed: For the cerebral cortex: - severe bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: postcentral gyrus (mild) - mild focal atrophy of frontal lobe on medial frontal cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the putamen - mild bilateral atrophy of the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For ventricles: - severe bilateral enlargement of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - moderate enlargement of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0299_MR_t1_mprage__br_raw_20170628141928568_110_S576566_I865949

On a T1-weighted brain MRI of a 65-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_011_S_4105_MR_MPRAGE_br_raw_20110719125904723_114_S115213_I245491

On a T1-weighted brain MRI of a 71-year-old female subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (moderate) and sup. frontal gyrus medial segment (mild) - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral enlargement of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_031_S_4218_MR_MPRAGE_br_raw_20110915140520234_92_S122024_I255978

On a T1-weighted brain MRI of a 81-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0176_MR_T1_mprage_S3_DIS3D_br_raw_20140831170526452_55_S228978_I441286

On a T1-weighted brain MRI of a 53-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For subcortical structures: - mild right atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_032_S_4348_MR_MPRAGE_br_raw_20111118112458497_150_S130131_I267561

On a T1-weighted brain MRI of a 67-year-old female subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: middle frontal gyrus (severe) and subcallosal area (mild) - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: postcentral gyrus (mild) - mild atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: sup. occipital gyrus (mild) - mild focal atrophy of temporal lobe on fusiform gyrus - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - moderate enlargement of the external csf - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle

Normal Aging

CN

ADNI_070_S_5040_MR_MPRAGE_br_raw_20121203120006533_63_S176060_I348757

On a T1-weighted brain MRI of a 76-year-old female subject, we observed: For the cerebral cortex: - mild atrophy of the occipital lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: lingual gyrus (mild), inf. occipital gyrus (mild) and sup. occipital gyrus (mild) - atrophies of frontal lobe on posterior orbital gyrus (mild) and precentral gyrus medial segment (mild) - moderate focal atrophy of temporal lobe on temporal pole - moderate focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild right atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0248_MR_t1_mprage__br_raw_20160902163301918_127_S495952_I772146

On a T1-weighted brain MRI of a 69-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (mild) - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_136_S_4727_MR_MPRAGE_br_raw_20120606151218245_114_S153015_I308415

On a T1-weighted brain MRI of a 74-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on triangular inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0271_MR_T1_mprage_S3_DIS3D_br_raw_20160903180503381_81_S496532_I772811

On a T1-weighted brain MRI of a 68-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on opercular inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - moderate enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_016_S_4952_MR_Accelerated_SAG_IR-SPGR__br_raw_20121002132023568_140_S169422_I337802

On a T1-weighted brain MRI of a 69-year-old female subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on triangular inf. frontal gyrus (mild) and supplementary motor cortex (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_082_S_4339_MR_MPRAGE_br_raw_20111110142444516_129_S128898_I265938

On a T1-weighted brain MRI of a 85-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on orbital inf. frontal gyrus (mild) and sup. frontal gyrus (mild) - atrophies of temporal lobe on transverse temporal gyrus (moderate), planum temporale (mild) and sup. temporal gyrus (mild) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0186_MR_T1_mprage_S3_DIS3D_br_raw_20140901082621101_25_S229348_I441701

On a T1-weighted brain MRI of a 49-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial orbital gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_941_S_4292_MR_MPRAGE_br_raw_20111205142922369_89_S131754_I269843

On a T1-weighted brain MRI of a 72-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of parietal lobe on angular gyrus - mild focal atrophy of occipital lobe on lingual gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_153_S_4372_MR_MPRAGE_br_raw_20111130171431062_134_S131410_I269347

On a T1-weighted brain MRI of a 71-year-old female subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: frontal pole (severe), middle frontal gyrus (moderate), sup. frontal gyrus (mild) and supplementary motor cortex (mild) - mild focal atrophy of temporal lobe on planum polare - mild focal atrophy of occipital lobe on cuneus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the parietal lobe For subcortical structures: - mild bilateral atrophy of the caudate - mild left atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the external csf - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle

Normal Aging

CN

ADNI_036_S_4878_MR_MPRAGE_br_raw_20120803114808529_80_S159481_I321504

On a T1-weighted brain MRI of a 73-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of occipital lobe on sup. occipital gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0301_MR_t1_mprage__br_raw_20160903223821943_13_S496932_I773276

On a T1-weighted brain MRI of a 61-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on triangular inf. frontal gyrus (mild), medial orbital gyrus (mild) and posterior orbital gyrus (mild) - severe focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - moderate bilateral atrophy of the accumbens, more pronounced on the right - mild bilateral atrophy of the putamen - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_073_S_4739_MR_MPRAGE_br_raw_20120516150253805_135_S150755_I304867

On a T1-weighted brain MRI of a 66-year-old male subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (mild) - mild atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: cuneus (mild) - mild focal atrophy of frontal lobe on precentral gyrus - atrophies of temporal lobe on temporal pole (mild) and middle temporal gyrus (mild) - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild right atrophy of the accumbens - mild left atrophy of the thalamus - mild left atrophy of the caudate - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - moderate enlargement of the external csf - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle

Normal Aging

CN

ADNI_127_S_4198_MR_Accelerated_Sag_IR-SPGR__br_raw_20110902083648052_131_S121087_I254317

On a T1-weighted brain MRI of a 78-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - mild focal atrophy of parietal lobe on postcentral gyrus - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_082_S_4224_MR_MPRAGE_br_raw_20110921173809009_175_S122960_I257382

On a T1-weighted brain MRI of a 76-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0313_MR_T1_mprage_S3_DIS3D_br_raw_20160909144402197_156_S498093_I774674

On a T1-weighted brain MRI of a 70-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild atrophy of the lateral ventricle - mild right atrophy of the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0281_MR_T1_mprage_S3_DIS3D_br_raw_20170817102624125_146_S597364_I890694

On a T1-weighted brain MRI of a 73-year-old female subject, we observed: For the cerebral cortex: - atrophies of temporal lobe on temporal pole (mild) and fusiform gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_2_S_0017_MR_MT1__GradWarp__N3m_Br_20120509155907422_S147140_I302626

On a T1-weighted brain MRI of a 61-year-old female subject, we observed: For the cerebral cortex: - mild atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: lingual gyrus (moderate), cuneus (mild) and sup. occipital gyrus (mild) - mild focal atrophy of temporal lobe on planum polare - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0238_MR_t1_mprage__br_raw_20160902144226204_127_S495765_I771932

On a T1-weighted brain MRI of a 67-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild right atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_094_S_4503_MR_Accelerated_SAG_IR-SPGR__br_raw_20120229095213816_59_S141558_I286228

On a T1-weighted brain MRI of a 72-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of occipital lobe on middle occipital gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0287_MR_t1_mprage__br_raw_20160903211742055_18_S496783_I773101

On a T1-weighted brain MRI of a 64-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0283_MR_t1_mprage__br_raw_20160903210340051_117_S496751_I773062

On a T1-weighted brain MRI of a 81-year-old female subject, we observed: For the cerebral cortex: - mild atrophy of the parietal lobe - atrophies of frontal lobe on gyrus rectus (moderate), posterior orbital gyrus (mild), orbital inf. frontal gyrus (mild) and medial frontal cortex (mild) - mild focal atrophy of limbic cortex on posterior cingulate gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe For subcortical structures: - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0284_MR_t1_mprage__br_raw_20170628135548125_85_S576477_I865837

On a T1-weighted brain MRI of a 63-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on subcallosal area (moderate), posterior orbital gyrus (mild) and opercular inf. frontal gyrus (mild) - mild focal atrophy of temporal lobe on temporal pole - moderate focal atrophy of insular cortex on central operculum - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_002_S_4264_MR_MPRAGE_br_raw_20111006131112761_140_S124589_I259796

On a T1-weighted brain MRI of a 75-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on planum polare - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - severe bilateral atrophy of the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild left enlargement of the inf. lateral ventricle - mild left enlargement of the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_041_S_4060_MR_MPRAGE_br_raw_20110601153106894_30_S110364_I238383

On a T1-weighted brain MRI of a 85-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For ventricles: - mild atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0245_MR_t1_mprage__br_raw_20160902154856522_149_S495886_I772073

On a T1-weighted brain MRI of a 66-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the caudate - mild bilateral atrophy of the thalamus - mild right atrophy of the pallidum - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - mild enlargement of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_013_S_4731_MR_MPRAGE_br_raw_20120605171549316_130_S152822_I308178

On a T1-weighted brain MRI of a 83-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on planum temporale - mild focal atrophy of occipital lobe on occipital pole - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala, more pronounced on the left - mild atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_012_S_4642_MR_MPRAGE_br_raw_20120411102800059_1_S146874_I296878

On a T1-weighted brain MRI of a 59-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0160_MR_T1_mprage_S3_DIS3D_br_raw_20140701124951616_139_S223881_I433960

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on frontal pole (mild) and subcallosal area (mild) - mild focal atrophy of temporal lobe on sup. temporal gyrus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild left atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_2_S_0012_MR_MT1__GradWarp__N3m_Br_20111229190758869_S133788_I274737

On a T1-weighted brain MRI of a 69-year-old male subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe - mild focal atrophy of occipital lobe on sup. occipital gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - mild bilateral atrophy of the caudate - mild atrophy of the putamen - mild left atrophy of the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0149_MR_T1_mprage_S3_DIS3D_br_raw_20140612225814523_48_S222077_I430646

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - atrophies of limbic cortex on posterior cingulate gyrus (mild) and middle cingulate gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_127_S_4148_MR_Accelerated_Sag_IR-SPGR__br_raw_20110811161518313_80_S118478_I250142

On a T1-weighted brain MRI of a 73-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the lateral ventricle, more pronounced on the left - no evidence of atrophy in the inf. lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0274_MR_t1_mprage__br_raw_20170814134905743_51_S576431_I865780

On a T1-weighted brain MRI of a 70-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0296_MR_t1_mprage__br_raw_20160903221807406_7_S496904_I773244

On a T1-weighted brain MRI of a 65-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of parietal lobe on angular gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0279_MR_t1_mprage__br_raw_20160903204551965_44_S496713_I773020

On a T1-weighted brain MRI of a 62-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - mild focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_032_S_4429_MR_MPRAGE_br_raw_20111222164722265_151_S134625_I274156

On a T1-weighted brain MRI of a 78-year-old male subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_018_S_4313_MR_MPRAGE_br_raw_20111128161650797_93_S131107_I268930

On a T1-weighted brain MRI of a 78-year-old female subject, we observed: For the cerebral cortex: - atrophies of temporal lobe on fusiform gyrus (mild) and planum temporale (mild) - mild focal atrophy of occipital lobe on occipital pole - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_003_S_4644_MR_Accelerated_SAG_IR-SPGR__br_raw_20120423161929609_181_S148163_I300196

On a T1-weighted brain MRI of a 68-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_035_S_4082_MR_MPRAGE_br_raw_20110628172140545_27_S112905_I242274

On a T1-weighted brain MRI of a 76-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - mild focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of occipital lobe on sup. occipital gyrus - mild focal atrophy of limbic cortex on entorhinal area - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the putamen - mild left atrophy of the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_137_S_4482_MR_MPRAGE_br_raw_20120216103107707_132_S140958_I285105

On a T1-weighted brain MRI of a 78-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the inf. lateral ventricle - mild right atrophy of the lateral ventricle - mild atrophy of the 4th ventricle - mild enlargement of the external csf - no evidence of atrophy in the 3rd ventricle

Normal Aging

CN

NIFD_1_S_0212_MR_T1_mprage_S3_DIS3D_br_raw_20170817105545257_129_S597537_I890918

On a T1-weighted brain MRI of a 53-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0239_MR_t1_mprage__br_raw_20160902150658769_33_S495785_I771956

On a T1-weighted brain MRI of a 77-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on supplementary motor cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_016_S_4121_MR_Accelerated_SAG_IR-SPGR__br_raw_20110721110431807_155_S115573_I246007

On a T1-weighted brain MRI of a 89-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of limbic cortex on posterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - moderate atrophy of the thalamus, more pronounced on the right - mild atrophy of the ventral dc, more pronounced on the right - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_2_S_0008_MR_MT1__GradWarp__N3m_Br_20111229190047421_S133665_I274730

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on sup. temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_135_S_4446_MR_MPRAGE_br_raw_20120117112205836_47_S136801_I278378

On a T1-weighted brain MRI of a 69-year-old female subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate) and frontal pole (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_036_S_4389_MR_MPRAGE_br_raw_20111208111740515_160_S132147_I270466

On a T1-weighted brain MRI of a 82-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on precentral gyrus (mild), sup. frontal gyrus medial segment (mild) and supplementary motor cortex (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - mild bilateral atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the external csf - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle

Normal Aging

CN

ADNI_016_S_4688_MR_Accelerated_SAG_IR-SPGR__br_raw_20120613093246999_171_S153817_I310326

On a T1-weighted brain MRI of a 82-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on orbital inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the ventral dc - mild atrophy of the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_023_S_4164_MR_MPRAGE_br_raw_20110908132522790_74_S120705_I253488

On a T1-weighted brain MRI of a 73-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on frontal pole (moderate), gyrus rectus (moderate), medial orbital gyrus (mild) and sup. frontal gyrus medial segment (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_2_S_0018_MR_MT1__GradWarp__N3m_Br_20120820135438042_S151967_I324982

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - moderate focal atrophy of frontal lobe on lateral orbital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_003_S_4441_MR_Accelerated_SAG_IR-SPGR__br_raw_20120110130312852_183_S135914_I277118

On a T1-weighted brain MRI of a 69-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of occipital lobe on sup. occipital gyrus - mild focal atrophy of limbic cortex on posterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the insular cortex For subcortical structures: - mild left atrophy of the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_099_S_4104_MR_MPRAGE_br_raw_20110701121555888_20_S113393_I243001

On a T1-weighted brain MRI of a 73-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of occipital lobe on middle occipital gyrus - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild right atrophy of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - mild enlargement of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0275_MR_t1_mprage__br_raw_20170628134416812_120_S576437_I865788

On a T1-weighted brain MRI of a 66-year-old male subject, we observed: For the cerebral cortex: - moderate focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - moderate bilateral atrophy of the basal forebrain - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - mild atrophy of the lateral ventricle - mild atrophy of the inf. lateral ventricle - mild atrophy of the 3rd ventricle - mild atrophy of the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_136_S_4433_MR_MPRAGE_br_raw_20120117163140145_52_S136879_I278511

On a T1-weighted brain MRI of a 77-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on triangular inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0231_MR_t1_mprage__br_raw_20160902114602280_102_S495583_I771719

On a T1-weighted brain MRI of a 70-year-old male subject, we observed: For the cerebral cortex: - mild atrophy of the limbic cortex - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_016_S_4951_MR_Accelerated_SAG_IR-SPGR__br_raw_20121002084753501_183_S169335_I337687

On a T1-weighted brain MRI of a 72-year-old female subject, we observed: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_018_S_4257_MR_MPRAGE_br_raw_20111024133019140_57_S126108_I262076

On a T1-weighted brain MRI of a 79-year-old male subject, we observed: For the cerebral cortex: - atrophies of temporal lobe on planum polare (mild) and middle temporal gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala, more pronounced on the left - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0289_MR_t1_mprage__br_raw_20170628140008007_55_S576470_I865828

On a T1-weighted brain MRI of a 60-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of temporal lobe on sup. temporal gyrus - moderate focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_073_S_4559_MR_MPRAGE_br_raw_20120224152757897_162_S141768_I286553

On a T1-weighted brain MRI of a 68-year-old female subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: posterior insula (moderate), parietal operculum (mild) and central operculum (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the inf. lateral ventricle - severe enlargement of the 4th ventricle - mild atrophy of the external csf - no evidence of atrophy in the 3rd ventricle

Normal Aging

CN

NIFD_1_S_0292_MR_t1_mprage__br_raw_20160903214429084_55_S496835_I773160

On a T1-weighted brain MRI of a 65-year-old male subject, we observed: For the cerebral cortex: - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: precuneus (mild) and sup. parietal lobule (mild) - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_037_S_4028_MR_MPRAGE_br_raw_20110425125155063_168_S105075_I228854

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - mild atrophy of the insular cortex, with focal volume reduction observed in the following subregions: parietal operculum (severe) - mild focal atrophy of frontal lobe on middle frontal gyrus - mild focal atrophy of occipital lobe on middle occipital gyrus - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe For subcortical structures: - mild left atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_082_S_4090_MR_MPRAGE_br_raw_20110621154128802_119_S112177_I241094

On a T1-weighted brain MRI of a 72-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on anterior orbital gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_016_S_4638_MR_Accelerated_SAG_IR-SPGR__br_raw_20120522105327181_179_S151234_I305876

On a T1-weighted brain MRI of a 74-year-old male subject, we observed: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_024_S_4158_MR_MPRAGE_br_raw_20110815114120024_16_S118583_I250350

On a T1-weighted brain MRI of a 85-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of limbic cortex on parahippocampal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0256_MR_t1_mprage__br_raw_20160902183701521_159_S496114_I772338

On a T1-weighted brain MRI of a 67-year-old male subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For ventricles: - mild bilateral atrophy of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0213_MR_T1_mprage_S3_DIS3D_br_raw_20170815200354578_115_S596034_I888892

On a T1-weighted brain MRI of a 47-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on supplementary motor cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild atrophy of the amygdala - mild atrophy of the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0171_MR_T1_mprage_S3_DIS3D_br_raw_20170815184406103_49_S260943_I494120

On a T1-weighted brain MRI of a 59-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild left atrophy of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_941_S_4066_MR_MPRAGE_br_raw_20110622130004782_120_S112064_I240920

On a T1-weighted brain MRI of a 79-year-old female subject, we observed: For the cerebral cortex: - mild bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: opercular inf. frontal gyrus (mild) and middle frontal gyrus (mild) - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild left enlargement of the lateral ventricle - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

NIFD_1_S_0180_MR_T1_mprage_S3_DIS3D_br_raw_20140831181136534_50_S229067_I441385

On a T1-weighted brain MRI of a 53-year-old male subject, we observed: For the cerebral cortex: - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (mild) - mild focal atrophy of frontal lobe on opercular inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - mild bilateral atrophy of the hippocampus - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild atrophy of the 4th ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_010_S_4442_MR_MPRAGE_br_raw_20120210180208528_27_S140482_I283915

On a T1-weighted brain MRI of a 75-year-old female subject, we observed: For the cerebral cortex: - mild atrophy of the parietal lobe - mild focal atrophy of frontal lobe on medial orbital gyrus - moderate focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_130_S_4343_MR_MPRAGE_br_raw_20111114125456890_31_S129057_I266217

On a T1-weighted brain MRI of a 80-year-old male subject, we observed: For the cerebral cortex: - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (moderate) - mild focal atrophy of temporal lobe on sup. temporal gyrus - mild focal atrophy of insular cortex on posterior insula - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - mild bilateral atrophy of the lateral ventricle - mild atrophy of the inf. lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_094_S_4560_MR_Accelerated_SAG_IR-SPGR__br_raw_20120326195612702_23_S144258_I291214

On a T1-weighted brain MRI of a 70-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - mild enlargement of the external csf - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle

Normal Aging

CN

ADNI_941_S_4376_MR_MPRAGE_br_raw_20120109153615951_58_S135785_I276860

On a T1-weighted brain MRI of a 77-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - moderate focal atrophy of parietal lobe on postcentral gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For subcortical structures: - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_073_S_5023_MR_MPRAGE_br_raw_20131009133645228_136_S203499_I393941

On a T1-weighted brain MRI of a 64-year-old female subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of insular cortex on posterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN

ADNI_941_S_4365_MR_MPRAGE_br_raw_20111129145025323_98_S131224_I269096

On a T1-weighted brain MRI of a 81-year-old male subject, we observed: For the cerebral cortex: - mild focal atrophy of frontal lobe on supplementary motor cortex - mild focal atrophy of insular cortex on posterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For subcortical structures: - mild bilateral atrophy of the caudate - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For ventricles: - no evidence of atrophy in the inf. lateral ventricle - no evidence of atrophy in the lateral ventricle - no evidence of atrophy in the 3rd ventricle - no evidence of atrophy in the 4th ventricle - no evidence of atrophy in the external csf

Normal Aging

CN