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Though decidedly silly, Groundhog Day is a direct and thriving descendant of age-old midwinter divinatory practices.What the Groundhog Is Really Telling Us
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Your brain on science! Neuroscientist Nancy Kanwisher shaves her head to show the location of her own brain regions.
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These resources address the diagnosis or management of ALSP: - Gene Review: Gene Review: Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia - Genetic Testing Registry: Hereditary diffuse leukoencephalopathy with spheroids - MedlinePlus Encyclopedia: Dementia These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care
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But I tried and I couldn't.
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You are home.
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Testicular cancer can usually be cured. Although the number of new cases of testicular cancer has doubled in the last 40 years, the number of deaths caused by testicular cancer has decreased greatly because of better treatments. Testicular cancer can usually be cured, even in late stages of the disease. (See the PDQ summary on Testicular Cancer Treatment for more information.)
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i havent worked out today but i feel like im just not going to feel it ive been so stressed at work and just in life that this week is just bad
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"As a nation, we've made extraordinary gains in longevity over the past decades, but as individuals we are regressing inHealthiest State Rankings Of 2012
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The Swiss team confirmed two confirmed cases among its skiers.Norovirus Spreads To Athletes At Winter Olympics
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Fast food restaurants aren't able to tout strong nutritional value or low fat in their burgers, burritos and shakes. So they're hoping by saying their food is fresh you'll falsely assume it's healthy. As if our country's obesity epidemic has been caused by people splurging on frozen foods.'Freshness' Doesn't Always Equal Good for You
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You can see Deepak's whole conversation with Michelle at NEWSWIRE.FM As caregivers in most societies, women are taught toThe Art of Empowering Women: Michelle King Robson
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Durant put up 30, most of those points coming in JUST THE FIRST HALF.Team USA Wins Third Straight Olympic Gold Beating Serbia In Rio
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i always feel horny when im done but its definitely a large flaccid and my penis is sleepy and hangs low
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i think that even just understanding that there s that history behind it it lends to the explanation of where it s being projected from so it s kind of important to some degree and i never feel offended by people questioning that
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This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition.
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My chest feels like I still smoke and have not started the post-smoking cough that most others (including myself in the past) get.
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Mr. Whammy finally returns to the Barclays Center.79-Year-Old Nets Superfan Finally Returns After He Says LeBron James Complained About Him
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What are the signs and symptoms of GTP cyclohydrolase I deficiency? The Human Phenotype Ontology provides the following list of signs and symptoms for GTP cyclohydrolase I deficiency. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of eye movement - Autosomal recessive inheritance - Choreoathetosis - Dysphagia - Dystonia - Episodic fever - Excessive salivation - Hyperkinesis - Hyperphenylalaninemia - Infantile onset - Intellectual disability, progressive - Irritability - Lethargy - Limb hypertonia - Progressive neurologic deterioration - Rigidity - Seizures - Severe muscular hypotonia - Tremor - Variable expressivity - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.
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i began to feel less anxious
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When ur sick and just want your bf to comfort u and take care of u but instead he screeches really loud and sends u a picture of holes when it’s ur biggest phobia and makes u even more nauseous aha. I just wanna be taken care of but then again he’s 15 and kind of immature lmao oop
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12 GIFs That Prove Our World Is Even More Beautiful Than It Seems
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i love to hear from my friends so feel free to leave me a comment
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PDGFRA-associated chronic eosinophilic leukemia is caused by mutations in the PDGFRA gene. This condition usually occurs as a result of genetic rearrangements that fuse part of the PDGFRA gene with part of another gene. Rarely, changes in single DNA building blocks (point mutations) in the PDGFRA gene are found in people with this condition. Genetic rearrangements and point mutations affecting the PDGFRA gene are somatic mutations, which are mutations acquired during a person's lifetime that are present only in certain cells. The somatic mutation occurs initially in a single cell, which continues to grow and divide, producing a group of cells with the same mutation (a clonal population). The most common genetic abnormality in PDGFRA-associated chronic eosinophilic leukemia results from a deletion of genetic material from chromosome 4, which brings together part of the PDGFRA gene and part of the FIP1L1 gene, creating the FIP1L1-PDGFRA fusion gene. The FIP1L1 gene provides instructions for a protein that plays a role in forming the genetic blueprints for making proteins (messenger RNA or mRNA). The PDGFRA gene provides instructions for making a receptor protein that is found in the cell membrane of certain cell types. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. When the ligand attaches (binds), the PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and cell survival. The FIP1L1-PDGFRA fusion gene (as well as other PDGFRA fusion genes) provides instructions for making a fusion protein that has the function of the normal PDGFRA protein. However, the fusion protein does not require ligand binding to be activated. Similarly, point mutations in the PDGFRA gene can result in a PDGFRA protein that is activated without ligand binding. As a result, the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells. When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in blood cell precursors, the growth of eosinophils (and occasionally other blood cells, such as neutrophils and mast cells) is poorly controlled, leading to PDGFRA-associated chronic eosinophilic leukemia. It is unclear why eosinophils are preferentially affected by this genetic change.
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Researchers from the University of Adelaide found that mistletoe extract is effective in killing colon cancer cells in aMistletoe Could Help Fight Colon Cancer, Study Finds
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Ridden by Victor Espinoza, Teddy's Promise ran 7 furlongs in 1 minute, 22.64 seconds on a dirt surface listed as wet-fast after earlier rain. The 5-year-old mare paid $5 on a $2 win bet as the 3-2 favorite in the field of seven. Sugarinthemorning finished second, and Kindle was another half-length back in third. Hall of Fame trainer Bob Baffert's duo of Distracting and Pink Lollipops finished fourth and seventh, respectively. Teddy's Promise drew the No. 4 post, forcing Espinoza to move her outside, where she prefers to run. ''There were two horses in front of me, and I just tracked them,'' he said. ''At the three-eighths pole, I kind of just let her do her own thing. And turning for home, I just let her run.'' Teddy's Promise went three-deep into the stretch and then took the lead nearing midstretch before pulling clear. ''She's back in form,'' trainer Ron Ellis said. ''She's really starting to relax and mature mentally. Physically, she's always been quite a specimen, but mentally, she's really turned a corner for us.'' Teddy's Promise was coming off a 5-1/4-length win in the Kalookan Queen Stakes as the 3-2 favorite on Dec. 29 at Santa Anita. ''That last race kind of got her a lot of confidence,'' Ellis said. ''I certainly don't think the mud hurts her. Her last one was on a little bit of a wet track. This was a muddier track today, but she won a Grade 1 on a fast track, so I think here at Santa Anita on the regular dirt it's a little bit better fit.'' Baffert's day wasn't a total wash. His horse, Fiftyshadesofhay, won the $100,000 Santa Ysabel Stakes for 3-year-old fillies by 5-3/4 lengths. Fiftyshadesofhay under Rafael Bejarano ran 1-1/16 miles in 1:42.89. She paid $14.40 as the 6-1 fourth choice in the field of five. Heir Kitty finished second for the second straight race. Scarlet Strike was another 1-1/2 lengths back in third as the 3-2 favorite. Fiftyshadesofhay finished eighth in the mile Blue Norther Stakes on the turf at Santa Anita on Jan. 1, an experiment Baffert labeled ''kind of disastrous.'' ''She can run all day long. She's fast, and she wants to be out there,'' he said. ''We were very high on her early in the year, and it's taken her a while to come around. But she ran like she's supposed to. She didn't like the turf.'' Scarlet Strike, who lost by a nose in the Blue Norther, has been no worse than third in eight career starts. ''Obviously, I thought we were going to win,'' jockey Joe Talamo said. ''We were pretty high on her coming in, but the track's so quick today, it's hard to make up any ground. They all seemed to run in place.''
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Kids from dog-owning homes also had fewer ear infections -- 44 percent fewer than kids from non dog-owning homes -- and neededPet Health Benefits: Study Shows Dogs And Cats May Make Kids Healthier
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My fiance said something that broke my heart and filled it at the same time. We were talking about me taking his last name when we marry (never thought I'd want to do that! But I so badly want to have the same family name, and he's attached to his and I'm not attached to mine.) He said he's afraid I'll face discrimination and maybe lose work if I take his obviously Muslim last name. The full force of all the discrimination he's faced hit me and broke my heart. He wants us to have the same last name too but doesn't want me to ever suffer. For him, my happiness is more important. I want his name now more than ever and if someone refuses to work with me based on my name I don't want their business. How did we get here that a name can cause fear and discrimination? I'll wear the name so proudly because to me it is the name of the sincerest love that exists.
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What are your go-to playground exercises? Tell us in the comments below. Love this playground workout? Keep it interesting30-Minute Bodyweight Workout At The Playground
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i start feeling myself getting overwhelmed or frustrated i have tried to open up more about it instead of pushing it down deep slapping on a fake smile and waiting until i boil over
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This week, Michelle Obama told iVillage that she often wakes up at 4:30 a.m. or 5 a.m. to exercise so she can get her sweat'Huh?' Health Headline Of The Week: Michelle Obama Gets Up How Early To Work Out?
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im feeling energetic this morning
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i feel more relaxed improvising in front of a group of other dancers as opposed to myself
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Regular health exams and tests can help find problems before they start. They also can help find problems early, when your chances for treatment and cure are better. Which exams and screenings you need depends on your age, health and family history, and lifestyle choices such as what you eat, how active you are, and whether you smoke. To make the most of your next check-up, here are some things to do before you go: - Review your family health history - Find out if you are due for any general screenings or vaccinations - Write down a list of issues and questions to take with you Centers for Disease Control and Prevention
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i feel like it was a bit rushed
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SpaceX holds a $1.6 billion contract with NASA for 12 robotic cargo delivery flights. By: Denise Chow Published: 06/30/2012Space Station Astronauts Return To Earth Sunday From ISS, NASA Says
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Awww look, a baby astrophysicist.2-Year-Old Neil DeGrasse Tyson Pens Awesome Birthday Thank You
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i am nowhere perfect but i feel helpless to save my family because they are so far away
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I often think about the first time you pulled me in, cradling the back of my neck, and softly grazing your tongue against mine.
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We currently have a statin epidemic, with 25 percent of adults over the age of 45 taking the pills, a large majority of whom do not have heart disease and have not seen the numbers.The Statin Insanity
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The NFL season is finally here. Are you ready? I know I am. I'll confess to all of you nice people on the internet (just between us), that I have a bit of a football addiction. Some might even call it a gambling addiction.Adventures of a Cranky Gambler
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It's demeaning. I get to decide who I love and no one else gets to override my feelings. If I love a man instead of a woman that's fine. That's great and wonderful and none of your business to tell me otherwise. If I love anyone for any number of reasons that's my choice. I get to decide who is worthy of my care and that's that.
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Through experience, we know that this is a time of year when we will be tested, both physically and emotionally. In turn, we will naturally come within and seek safety from the elements.Is Snow Your Security Blanket? It Should Be This Year
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i feel so horny just thinking about this
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New RNA-Seq template preparation protocol enables detection of imprinted macro ncRNAs
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As human awareness expands and evolves over time, we uncover more fundamental aspects of what it means to be a human being and what it means to be alive, and our values, morality, and sense of meaning, in turn, expand and evolve to include more.Evolution and Culture
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i feel that im much more productive i get less distracted and i feel so much more accomplished
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i had a real life pet hamster when i was little so i really like this little family sylvanian families are great for role play learning about animals creating your own stories and their flocked fur makes them feel very special
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i complete the act i feel temporarily satisfied but the feeling quickly goes away and i feel ashamed or guilty
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I remember that the morning after my own diagnosis: I sat up in bed, I put my feet on the ground, I started to cry... but only for about 60 seconds. Then I said to myself (out loud), "This disease is not going to kill me." I believed it then, and I believe it now. That was over four years ago.Cancer and the Mindset of Healing
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Behind the scenes during the shoot (Damon Dahlen/The Huffington Post) And because all the ingredients are pre-loaded intoGluten-Free Breakfast: My 'Quick-Trick-Snack Stack'
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I feel like im not being taken seriously. I feel unsafe being at home, From myself and him''
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Hopefully no one was hurt.Fight In Bathroom Stall At Giants Game Shows Fans Flush With Anger
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With the Saints QB leading the way, AdvoCare is using its sports ties to build a nutrition empire. But is the company really pushing false hope?Drew Brees Has A Dream He'd Like To Sell You
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Freiberg's disease is rare condition that primarily affects the second or third metatarsal (the long bones of the foot). Although people of all ages can be affected by this condition, Freiberg's disease is most commonly diagnosed during adolescence through the second decade of life. Common signs and symptoms include pain and stiffness in the front of the foot, which often leads to a limp. Affected people may also experience swelling, limited range of motion, and tenderness of the affected foot. Symptoms are generally triggered by weight-bearing activities, including walking. The exact underlying cause of Freiberg's disease is currently unknown. Treatment depends on many factors, including the severity of condition; the signs and symptoms present; and the age of the patient.
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It can be the focus of inconsolable grief ; it inspires poetry and literature , symphonies and song
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Mutations in the ETHE1 gene cause ethylmalonic encephalopathy. The ETHE1 gene provides instructions for making an enzyme that plays an important role in energy production. It is active in mitochondria, which are the energy-producing centers within cells. Little is known about the enzyme's exact function, however. Mutations in the ETHE1 gene lead to the production of a nonfunctional version of the enzyme or prevent any enzyme from being made. A lack of the ETHE1 enzyme impairs the body's ability to make energy in mitochondria. Additionally, a loss of this enzyme allows potentially toxic compounds, including ethylmalonic acid and lactic acid, to build up in the body. Excess amounts of these compounds can be detected in urine. It remains unclear how a loss of the ETHE1 enzyme leads to progressive brain dysfunction and the other features of ethylmalonic encephalopathy.
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i know for a fact that he treated everyone this way his love seemed boundless but he also made me feel important
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He asked if he could call, I said if he doesn't mind seeing me since I am in the dark it's fine. He called and I was watching him all through the entire hour as we spoke. We had a meaningful conversation which left me feeling wholesome.
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But anticipating obstacles ahead of time can help you stay on track. In psychology, this is known as the hot-cold empathyThis Is Why You Can Never Keep Your New Year's Resolutions
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i feel i am on an emotional roller coaster
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Jason Whitlock writes about the sports world from every angle, including those other writers can't imagine or muster courage to address. His columns are humorous, thought-provoking, agenda-free, honest and unpredictable. E-mail him or follow his Twitter or become a fan of Jason Whitlock on Facebook. The return of Pau Gasol and Steve Nash to the lineup is likely to mask most, if not all, the symptoms afflicting the underachieving Los Angeles Lakers. But the perennial all-stars will do nothing to address the disease lurking deep inside the foundation of the Lakers, the malady that will prevent the high-priced collection of veterans from getting past the Thunder, Spurs or even the Grizzlies come playoff time. The root cause of the Lakers’ dysfunction has been consistent for 15 years. It is Kobe Bryant’s ego, his desperate pursuit of Michael Jordan’s legacy. L.A.’s Dwight Howard experiment is going to explode and implode in spectacular fashion unless someone in the Lakers organization is bold enough to kill Kobe’s Michael Jordan avatar so that Howard’s Bill Russell avatar can emerge and lead the Lakers. You follow? The wrong player is driving the Lakers. Dwight Howard is the second-most talented player in the league. He’s the single-most gifted defensive player the NBA has seen since Bill Russell. On a properly functioning, championship-chasing team, Howard cannot be a sidekick, a No. 2, Scottie Pippen. Can’t happen. The Heat tried it with LeBron James in Year 1 of the Big Three, and we know how that ended. Dwyane Wade is an awesome basketball player and a terrific leader, but he had to surrender the soul of the Heat to LeBron in order for the Heat to win a title. Kobe has to let go and let D12. Has to. Kobe has to accept that he is not the 34-year-old Michael Jordan. You see, at 34 Jordan was taking his final victory lap in Chicago, completing his second three-peat, securing his sixth title, winning his fifth MVP award and 10th scoring title. Kobe wants to duplicate that feat. He’s putting up MVP-like numbers. He leads the league in scoring. He’s shooting a career-high 47.8 percent from the field. He’s averaging five rebounds and five assists. He’s knocking down 38 percent of his 3-pointers. Oh, the numbers look great. The results? The Lakers stink. You can blame that on the injuries to Gasol and Nash. You can blame it on the incompetence of D’Antoni. I blame Kobe. He’s the guy stopping Howard from eating. Kobe is the guy giving Howard room to lose himself in his immaturity and hide. Here’s what Kobe has never understood about the Los Angeles Lakers. It’s an organization built to house and nurture giants. From George Mikan to Wilt Chamberlain to Kareem Abdul-Jabbar to Shaquille O’Neal, the Lakers function best when the once-in-a-generation big man the organization acquires is allowed to be the man of the house. Kobe emasculates his big men. Andrew Bynum politely admitted this week that Kobe stunted his growth. “I think Dwight is a great player, but he’s going to have to get accustomed to playing with Kobe and not touching the ball every single play,â€‌ Bynum said. The problem is deeper than touches. It’s a mentality that a big man must have in order to lead his team. Dwight Howard must enter every NBA arena with this mindset: “If I don’t hunt and kill, no one eats tonight.â€‌ That’s Kobe’s mindset. But at 34, having played 1,186 regular-season games and 220 playoff games, Kobe doesn’t hunt and kill as effectively as Howard. Kobe isn’t the same as a 34-year-old Jordan. At this stage in his career, Jordan had played 873 regular-season games and 158 playoff games. Jordan was still a force of nature. Don’t get fooled by Kobe’s numbers. He’s not Kevin Durant or Carmelo Anthony, and Kobe damn sure isn’t LeBron James. James, Durant and Melo can impose their will on the opposition. Over the course of a seven-game playoff series, they can mentally bludgeon an opponent into submission. We saw James do it to the Pacers and the Celtics in last year’s playoffs. Kobe is smart. He can be efficient. But he’s trying too hard right now. That’s why he leads the league in turnovers with 97. Kobe’s days of imposing his will in a playoff series are over. Howard’s days should just be beginning. If you have a question or comment for Jason, submit it below and he may just respond. Subject: Comment/Question: Name: Email Address: Hometown: But Kobe’s ego is in the way. Howard can’t be the man of the house with Kobe sitting at the head of the table eating the biggest plate of food. As long as everything revolves around Kobe, as long as Kobe is on TV sitting across from Stephen A. Smith speaking in hushed, dark tones about the state of the Lakers, Howard gets to hide, gets to feel like the Lakers family can eat regardless of whether he chooses to hunt or not. Kobe needs to fall back. He’s Dr. J right now and he needs to let Dwight Howard be Moses Malone. That does not mean turn the offense over to Howard. It means building a strategy and philosophy that revolves around Howard’s many gifts, which are mostly at the defensive end (and make the hiring of D’Antoni even more ridiculous). It means forcing Howard to mentally and verbally take full responsibility for the success of the team. Howard is immature. We know that. We watched him in Orlando. Put some pressure on his ass. Make Howard explain why this team is underachieving. I know this column will appear to many as hatred of Kobe. I don’t hate Kobe. He’s a wonderful player and terrific competitor. He simply has to make the mental adjustment that Dwyane Wade made last season. Come May and June, the Lakers are going as far as Dwight Howard can take them. Nash and Gasol might help the Lakers recover and get into the playoffs. And Kobe is certainly capable of continuing to put up big numbers. But the Lakers are not winning a title if their second-best player continues to stunt the growth of their best player.
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OK, climate change, this really isn't cool anymore.The Biggest Dog Sledding Race In The World Is Having Major Problems. You Already Know Why
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Drills are the direct route to becoming a safe and efficient runner, and training volume is valuable only insofar as our good technique can be maintained.Running Form: Simplified (Part 5)
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There's no sense in wasting time pretending to be someone you're not so that you'll fit in with the people you don't belong with. Life is short, spend it with people who love and appreciate the real you.The Number One Way People Screw Up Life -- Are You Making This Mistake?
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Few days ago, I got invited to this birthday party and I found out that she is attending it too. When I found I got really mixed emotions. No matter how hard I don’t want to go and forget her, somehow I can’t fight my heart which wants to see her on every possible opportunity. I’m extremely lost and still fighting depression which might get even stronger after that party. If she comes with boyfriend it will be even harder, I’m afraid that I might get aggressive and say too much.
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So you can see why mothers get angry when they discover that even everyday foods such as apples can cause a build-up of unwanted chemicals in their children 's bod
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i feel that he s being sincere when he says that he does love me but there s this whole other part of me that keeps telling me that he still loves the other girl
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If you don't like the idea of a class, try dancing in the privacy of your own home -- then you really will be dancing like no one's watching. At the very least, it will make you smile.Twirling Dervish
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Plus, "the number of true Bradys with pacemakers may have been underestimated, because female patients with pacemakers whosePeople With The Last Name 'Brady' More Likely To Have Bradycardia, Study Finds
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Robotic Surgeries Technological Approaches and AI- Based Modern Procedures Boost the Surgical Robots Market Revenue in Future
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What COVID-19 means for the athlete’s heart
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Mutations in the WT1 gene cause Frasier syndrome. The WT1 gene provides instructions for making a protein that regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor. The WT1 protein plays a role in the development of the kidneys and gonads (ovaries in females and testes in males) before birth. The WT1 gene mutations that cause Frasier syndrome lead to the production of a protein with an impaired ability to control gene activity and regulate the development of the kidneys and reproductive organs, resulting in the signs and symptoms of Frasier syndrome. Frasier syndrome has features similar to another condition called Denys-Drash syndrome, which is also caused by mutations in the WT1 gene. Because these two conditions share a genetic cause and have overlapping features, some researchers have suggested that they are part of a spectrum and not two distinct conditions.
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i just wish okay so i was thinking about it earlier today and heres the thing being all cooped up amp restless has made me feel so needy
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It would open the door for more trans athletes to compete internationally.Read The Olympics' New Transgender Guidelines That Will Not Mandate Surgery
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Hereditary sensory autonomic neuropathy (HSAN) is a group of rare peripheral neuropathies where neurons and/or axons are affected. The major feature of these conditions is the loss of large myelinated and unmyelinated fibers. Myelin is an insulating layer, or sheath that forms around nerves, made up of protein and fatty substances, that allows electrical impulses to transmit along the nerve cells. If myelin is damaged, these impulses slow down. Symptoms of HSAN include diminished sensation of pain and its associated consequences of delayed healing, Charcot arthopathies, infections, osteomyelitis, and amputations. They have been categorized into types one through five, although some children do not fit well into this classification and do not all have altered pain sensation and/or autonomic function.[9873] HSAN type I is the most common form of HSAN. It is caused by a mutation in the SPTLC1 gene and inherited in an autosomal dominant pattern. HSAN type 2 is caused by mutations in the WNK1 gene and inheritance is autosomal recessive . HSAN type 3 (Riley-Day syndrome or familial dysautonomia) is caused by mutations in the IKBKAP gene and inheritance is autosomal recessive. HSAN type 4, also called congenital insensitivity to pain with anhidrosis (CIPA), is caused by mutations in the NTRK1 gene and is an autosomal recessive disorder. HSAN type 5 is caused by mutations in the NGFB gene and inherited in an autosomal recessive manner.
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Mutations in the SRY gene have been identified in approximately 15 percent of individuals with Swyer syndrome. The SRY gene, located on the Y chromosome, provides instructions for making the sex-determining region Y protein. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The sex-determining region Y protein starts processes that are involved in male sexual development. These processes cause a fetus to develop male gonads (testes) and prevent the development of female reproductive structures (uterus and fallopian tubes). SRY gene mutations that cause Swyer syndrome prevent production of the sex-determining region Y protein or result in the production of a nonfunctioning protein. A fetus whose cells do not produce functional sex-determining region Y protein will not develop testes but will develop a uterus and fallopian tubes, despite having a typically male karyotype. Swyer syndrome can also be caused by mutations in the MAP3K1 gene; research indicates that mutations in this gene may account for up to 18 percent of cases. The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body. These include the processes of determining sexual characteristics before birth. The mutations in this gene that cause Swyer syndrome decrease signaling that leads to male sexual differentiation and enhance signaling that leads to female sexual differentiation, preventing the development of testes and allowing the development of a uterus and fallopian tubes. Mutations in the DHH and NR5A1 genes have also been identified in small numbers of people with Swyer syndrome. The DHH gene provides instructions for making a protein that is important for early development of tissues in many parts of the body. The NR5A1 gene provides instructions for producing another transcription factor called the steroidogenic factor 1 (SF1). This protein helps control the activity of several genes related to the production of sex hormones and sexual differentiation. Mutations in the DHH and NR5A1 genes affect the process of sexual differentiation, preventing affected individuals with a typically male karyotype from developing testes and causing them to develop a uterus and fallopian tubes. Changes affecting other genes have also been identified in a small number of people with Swyer syndrome. Nongenetic factors, such as hormonal medications taken by the mother during pregnancy, have also been associated with this condition. However, in most individuals with Swyer syndrome, the cause is unknown.
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['Health']
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Ways to prevent heart failure include - keeping your cholesterol and blood pressure levels healthy - keeping diabetes in check - maintaining a healthy weight - quitting smoking - following a heart healthy diet - limiting the amount of alcohol you drink - eating a diet low in salt because salt can cause extra fluid to build up in your body and also contribute to high blood pressure. Older adults should limit their sodium (salt) intake to1500 mg a day (about 2/3 tsp of salt). - getting regular exercise. Aim for at least 30 minutes a day of exercise. Check with your doctor before starting any exercise program. For information about exercises that older adults can do safely, see Exercises to Try or visit Go4Life, the exercise and physical activity campaign for older adults from the National Institute on Aging. keeping your cholesterol and blood pressure levels healthy keeping diabetes in check maintaining a healthy weight quitting smoking following a heart healthy diet limiting the amount of alcohol you drink eating a diet low in salt because salt can cause extra fluid to build up in your body and also contribute to high blood pressure. Older adults should limit their sodium (salt) intake to1500 mg a day (about 2/3 tsp of salt). getting regular exercise. Aim for at least 30 minutes a day of exercise. Check with your doctor before starting any exercise program. For information about exercises that older adults can do safely, see Exercises to Try or visit Go4Life, the exercise and physical activity campaign for older adults from the National Institute on Aging.
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Why Coffee Is Healthy for Seniors!
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['Science']
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Kobe Bryant and the Los Angeles Lakers really think they're on to something, even if it's nothing revolutionary. They're gaining confidence in their newfound attitude and approach with each victory they're producing. Not even a fantastic fourth-quarter rally by the New Orleans Hornets could shake Kobe's conviction that the Lakers have finally figured out a few things about their puzzling season. Dwight Howard scored 24 points, Bryant had 14 points and 11 assists in another pass-first performance, and the Lakers hung on to beat New Orleans 111-106 Tuesday night for their first three-game winning streak in five weeks. Earl Clark had 20 points and 12 rebounds for the Lakers (20-25), who jumped to an 18-point lead midway through the fourth quarter with their third straight game of patient passing and hard-nosed defense quarterbacked by Bryant. The fifth-leading scorer in NBA history has warmly embraced his new role as a playmaker - no surprise for somebody whose first basketball muse was Magic Johnson. ''It's working pretty well,'' said Bryant, whose 39 assists in the Lakers' last three games are the biggest three-game total of his 17-season career. ''It's very easy for me to look over the defense and know where they're coming from, just kind of line my guys up in the right way and just pick them apart.'' With Bryant running the show, the Lakers even survived a frenetic finish. Their lead dwindled to 102-101 with 2 minutes left shortly after an electric 16-2 run in a 2 1/2 minute stretch by the Hornets, but Clark hit a layup and Steve Nash calmly buried a 3-pointer with 1:21 left to clinch Los Angeles' ninth straight win over New Orleans. Nash had 12 points and five assists, while Antawn Jamison scored 16 points. Four-time All-Star Pau Gasol had seven points, seven rebounds and seven assists as a reserve in the Lakers' final home game before a seven-game trip, their longest of the season, while the Grammy Awards take over Staples Center. The trip should be daunting for the Lakers, who have lost 15 of 20 on the road this season, including seven straight since Christmas. Instead, they're optimistic about trying out their new approach in a hostile environment. ''We're doing a good job of not being selfish, and of doing whatever we can to help our team win,'' Howard said. ''Things are clicking for us. Our offense is a lot smoother, and on defense we're really holding each other accountable.'' Sounds simple - but the Lakers have rarely looked this good in their complex season. Eric Gordon scored 18 of his 25 points in the first half for the Hornets, who got within one point on Greivis Vasquez's running jumper. Ryan Anderson scored 11 of his 16 points in the fourth quarter for the Hornets, who had won eight of 12, including an impressive victory in Memphis two nights earlier at the start of their five-game trip. Anderson, Vasquez and Robin Lopez led the impressive late rally that just fell short, with Lopez finishing with 16 points and nine rebounds. ''We're a young team that's still building chemistry, and to come back like that is a really good confidence boost for the guys,'' said Gordon, a Staples Center favorite in his career with the Clippers. ''We had a chance to win. We were getting a lot of stops and were scoring at will. It just boiled down to the final plays.'' Rookie Anthony Davis had 18 points for the Hornets, who haven't beaten the Lakers at Staples Center since January 2009. Bryant reached new statistical heights in his revamped role, racking up 10 assists in three straight games for just the fifth time in his career and the first time in four years. Bryant also had eight rebounds, falling just short of a triple-double for the third straight game. Two days after beating Oklahoma City in impressive fashion, the Lakers got right back to their improved form in the first half, holding the Hornets scoreless for 7:41 spanning the first two quarters with a 17-0 run. ''Even though we were down 18, we should have won the game,'' Vasquez said. ''It's hard losing like that, but I thought we battled. We just can't get down by 18. We can't allow us to do that to ourselves. We've got to bring the juice from the beginning. We're good enough to beat anybody if we just play with energy. If we don't play with energy, it's going to be a long night.'' Notes: The Hornets' brutal road trip began in Tennessee and will eventually take them to Minnesota for their fourth game in five nights on Saturday. They'll be at Utah on Wednesday night. ... Steve Blake had two points and four assists in the veteran guard's first appearance for the Lakers since Nov. 11. He had missed the Lakers' past 37 games with an abdominal injury that required surgery and resulting groin problems. ... The Lakers missed four free throws in less than 1 second of clock time midway through the third quarter. After Howard missed two, Gasol grabbed the rebound and got fouled without the clock moving - but Gasol then missed two as well. Clark collected that rebound, but threw it past Bryant for a backcourt violation.
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i feel no need to work up acceptable conversation fodder
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He is the articulation of desires that my conscious mind could not comprehend. I never looked for him but I found him and now I can't be without him. He is my proof that prayer works.
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Kylie Jenner sports ex Travis Scott's new sneakers before anyone else
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Looking down at the dead man Wycliffe felt guilty because he was experiencing a sense of mild elat
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camel milk benefits
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Thanks to your fairy godmother and Steve Jobs you just need to find the right app, consult it every five minutes and maybe offer up a human sacrifice now and then and your dreams will come true.Multitasking: There's an App for That
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i thought it would be interesting to share because the philosophy of love and soulmates has always been so mysterious and sought after.
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The spine is the heart of the nervous system, according to Khouri, which makes perfect sense. Tension in the low back orYoga and Stress Relief: Benefits From the Mat
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i am mellow and feeling particularly fond of all the human race i don t blame fertile people for not really knowing what to say or what to think or how to deal with it all
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Memorial Day is a day of remembrance of those who have died in our nation's service. Regardless of what our opinions are about war, one fact remains: There are thousands of people who survive who are in great need of healing.Films for Your Soul: Healing a War-Torn Spirit (WATCH)
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i feel like im not being loyal to my boyfriend even though i have not acted on my feelings for this guy
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Kids need to learn how to fail, take responsibility for themselves, and love learning.Vindication for Lazy Parents (Like Me)
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i visit cantina i leave feeling that the food is lovely but not always worth the price
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i left the property feeling insulted and found myself minutes later on main street an unsuspecting victim of some unknown enemy s next attack
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As long as you're washing them regularly, sheets shouldn't pose much of a mite problem though. Because 86 percent of peopleHow Long Ago Did You Buy Your Mattress, Pillows And Sheets? (INFOGRAPHIC)
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After months of chemotherapy, Berry is back where he belongs.NFL Player Eric Berry Returns Home After Beating Cancer
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FIND SOMEONE WHO KNOW YOU’RE SAD JUST BY THE CHANGE OF TONE IN YOUR VOICE !!! 💖💖💖
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im feeling terrified no control and now my world is shaking the curtains close and it tingles and tickles inside in my pulse
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i have not written is that i am still feeling angry about something that happened on friday which seems to have invaded my happy place with recurring angry thoughts
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Watch out, stationary bike. Across the country, boatloads of people are dipping their toes into the water (sorry), resulting in a surge of indoor-rowing classes. We recently popped in for a lesson at our local gym to see what all the fuss is about.Add Indoor Rowing to Your Repertoire
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Published in the Journal of the American Medical Association, researchers from St. Michael's Hospital found that one in fiveTeens And Traumatic Brain Injury: One In Five Canadian Teens Reports Experiencing One
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