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The pharmacodynamic effects of ticagrelor were preserved when ticagrelor was given during infusion of cangrelor . | [{'class': 'POS', 'spans': ['ticagrelor', 'cangrelor'], 'is_context_needed': False}] |
A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin , paclitaxel , and bevacizumab with partial response . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'bevacizumab'], 'is_context_needed': True}] |
Sipuleucel-T , cabazitaxel , abiraterone , enzalutamide and radium-223 have been approved in the pre- or post-docetaxel setting in metastatic CRPC during the last few years . | [{'class': 'POS', 'spans': ['Sipuleucel-T', 'cabazitaxel', 'abiraterone', 'enzalutamide', 'radium-223'], 'is_context_needed': True}] |
Therefore , we conducted this phase II study to evaluate the activity and toxicity of the combination paclitaxel and gemcitabine in advanced NSCLC . | [{'class': 'NEG', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
Ciprofloxacin , 500 mg orally twice a day plus antifungal prophylaxis , fluconazole 50 mg once daily plus amphotericin B tablets or suspension and tablets , each 200 mg four times a day , was given . | [{'class': 'POS', 'spans': ['Ciprofloxacin', 'fluconazole', 'amphotericin'], 'is_context_needed': True}] |
In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) . | [{'class': 'POS', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': False}] |
A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation . | [{'class': 'POS', 'spans': ['vemurafenib', 'cobimetinib', 'VEMUPLINT'], 'is_context_needed': True}] |
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma . | [{'class': 'NEG', 'spans': ['tremelimumab', 'sunitinib'], 'is_context_needed': True}] |
A working group convened by the Centers for Disease Control recommended three antibiotics for the treatment of recurrent and persistent acute otitis media : ( 1 ) amoxicillin/clavulanate in combination with amoxicillin ( high dose amoxicillin regimen , 80 to 90 mg/kg/day ) ; ( 2 ) cefuroxime axetil ( standard dose , 30 mg/kg/day ) ; and ( 3 ) ceftriaxone ( possibly requiring up to three injections to optimize clinical success ) . | [{'class': 'POS', 'spans': ['amoxicillin/clavulanate', 'amoxicillin'], 'is_context_needed': True}] |
Patients who had failed only one prior chemotherapy regimen and had Eastern Cooperative Oncology Group ( ECOG ) Performance Status ( PS ) ≤2 were randomised to either : pemetrexed 500 mg/m(2 ) on day 1 plus erlotinib 150 mg daily on days 2 - 14 ; erlotinib 150 mg daily ; or pemetrexed 500 mg/m(2 ) on day 1 of a 21-day cycle until discontinuation criteria were met . | [{'class': 'POS', 'spans': ['pemetrexed', 'erlotinib'], 'is_context_needed': True}] |
This study was conducted to test the feasibility of reducing the interval between cycles of doxorubicin , cyclophosphamide , etoposide ( ACE ) chemotherapy to 2 weeks , thereby increasing dose intensity , by adding granulocyte colony-stimulating factor ( G-CSF ) to reduce the duration of neutropenia following a cycle . | [{'class': 'POS', 'spans': ['doxorubicin', 'cyclophosphamide', 'etoposide', 'G-CSF'], 'is_context_needed': True}] |
The rate of down-stage to pT1 or less was 59 % for methotrexate , vinblastine , doxorubicin and cisplatin , and 53 % for gemcitabine and carboplatin ( P = 0.624 ) . | [{'class': 'POS', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
The combined irrigation of bupivacaine and ketorolac showed a clinically significant reduction of pain in the first postoperative hour and on postoperative day 5 . | [{'class': 'POS', 'spans': ['bupivacaine', 'ketorolac'], 'is_context_needed': False}] |
In group I , clinical response was observed in 10 of 19 febrile episodes ( 52.6 % ) treated with carbenicillin plus gentamicin and in 10 of 14 ( 71.4 % ) treated with latamoxef ( p greater than 0.05 ) . | [{'class': 'COMB', 'spans': ['carbenicillin', 'gentamicin'], 'is_context_needed': True}] |
Following lapatinib and trastuzumab , the HER2-E and ERBB2 (HER2-E/ERBB2)-high group showed a higher pCR rate compared to the rest ( 44.5 % , 95 % confidence interval [ CI ] = 35.4 % to 53.9 % vs 11.6 % , 95 % CI = 6.9 % to 18.0 % ; adjusted odds ratio [ OR ] = 6.05 , 95 % CI = 3.10 to 11.80 , P < .001 ) . | [{'class': 'POS', 'spans': ['lapatinib', 'trastuzumab'], 'is_context_needed': False}] |
A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model . | [{'class': 'POS', 'spans': ['Troglitazone', 'Lovastatin'], 'is_context_needed': False}] |
Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest . | [{'class': 'POS', 'spans': ['Fingolimod', 'lapatinib'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Bacteriological , histopathologic , and clinical outcomes after treatment using moxifloxacin , moxifloxacin and dexamethasone combination , and vancomycin were comparable . | [{'class': 'COMB', 'spans': ['moxifloxacin', 'dexamethasone'], 'is_context_needed': True}] |
Combining erythromycin , clarithromycin , or azithromycin with rifampin resulted in a significant ( P≤0.005 ) decrease in MPC and MPC/MIC ratio . | [{'class': 'POS', 'spans': ['erythromycin', 'rifampin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
This was confirmed and show that the dCK levels are retained upon co-treatment , indicating a clinical use for bortezomib treatment in combination with cytarabine to avoid development of resistance . | [{'class': 'POS', 'spans': ['bortezomib', 'cytarabine'], 'is_context_needed': False}] |
Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets . | [{'class': 'NEG', 'spans': ['fenofibrate', 'lovastatin'], 'is_context_needed': True}] |
Idasanutlin was tolerable alone and in combination with cytarabine . | [{'class': 'POS', 'spans': ['Idasanutlin', 'cytarabine'], 'is_context_needed': False}] |
After seven days of chemotherapy with 5-fluorouracil , oxaliplatin and bevacizumab , exploratory surgery revealed a perforation at the ileum . | [{'class': 'NEG', 'spans': ['5-fluorouracil', 'oxaliplatin', 'bevacizumab'], 'is_context_needed': False}] |
Nausea graded none or mild 24 h after the start of cisplatin infusion was reported in 71 and 69 % of patients in the 8- and 32-mg ondansetron groups , respectively , and in 73 % of patients in the granisetron group . | [{'class': 'POS', 'spans': ['cisplatin', 'ondansetron'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
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