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biosynthesis Biosynthesis |
heterocyclic;hydroxy;deprotonation;forskolin;hydroxy group;quenched;cyclization;carbocation;allylic The heterocyclic ring is synthesized after the formation of the trans-fused carbon ring systems formed by a carbocation mediated cyclization. The remaining tertiary carbocation is quenched by a molecule of water. After deprotonation, the remaining hydroxy group is free to form the heterocyclic ring. This cyclization can occur either by attack of the alcohol oxygen onto the allylic carbocation formed by loss of diphosphate, or by an analogous SN2'-like displacement of the diphosphate. This forms the core ring system A of forskolin. |
esterified;esterification;forskolin;gene cluster The remaining modifications of the core ring system A can putatively be understood as a series of oxidation reactions to form a poly-ol B which is then further oxidized and esterified to form the ketone and acetate ester moieties seen in forskolin. However, because the biosynthetic gene cluster has not been described, this putative synthesis could be incorrect in the sequence of oxidation/esterification events, which could occur in almost any order. |
lean body mass;barbatus;forskolin In animals, forskolin, or extracts of Coleus barbatus containing forskolin, reduce food intake, body weight, and fat mass. In humans, forskolin reduces body fat mass while increasing lean body mass. In mice, extracts of Coleus forskohlii exhibited dose-dependent liver toxicity although purified forskolin did not exhibit liver toxicity. |
forskolin Forskolin has been used in traditional medicine for treating heart failure. |
adenylyl cyclase;cyclase;adenylyl Adenylyl cyclase |
cyclic amp;amp Cyclic AMP |
forskolin;science-based medicine Hall, Harriet (2014-06-03). "Forskolin: Here We Go Again". Science-Based Medicine. Retrieved 2017-04-12. |
elvio jimenez;dow;tom pratt;elvio Clarence G. Dow (October 2, 1854 – March 11, 1893) was a Major League Baseball outfielder. He played for the 1884 Boston Reds in the Union Association. Dow appeared in one game for the Reds and had two hits in six at-bats. Dow along with Elvio Jimenez and Tom Pratt, are the only players to have six at-bats in their only MLB game. |
nanyang technological university;jtc corporation;launchpad;nanyang;bahar;jid;cleantech park;bulim;jurong;tengah;jtc;cleantech CleanTech Park is an eco-business park in Singapore, the first in the nation. R&D and test-bedding site for early adoption of green technology and solutions. Under development in three phases with a proposed completion year of 2030, the Park's first multi-tenanted building, CleanTech One, was opened in October 2010. The 50 hectares (120 acres) site is located adjacent to Nanyang Technological University, which plans an integration between the sites as part of its own expansion. In addition to focusing on hosting environmentally friendly industry, the complex is being developed by JTC Corporation with an eye towards environmentally responsible practices, with "green" buildings and maintenance of natural terrain. Together with other precincts such as Nanyang Technological University, Bulim, Tengah, Bahar and CleanTech Park & LaunchPad @ JID forms the future 600-hectare Jurong Innovation District.CleanTech Park currently consist of the following buildings: |
cleantech CleanTech One |
cleantech CleanTech Two |
jid;launchpad Launchpad @ JID |
carcassonne;occitania;nova cancon;claudi marti;aude;cancon;marti;claudi Claudi Marti (born 6 March 1940 in Carcassonne, Aude) is an Occitan singer from the Carcassonne region in Occitania. He was one of the main figures of Nova cancon in the 1970s. |
occitania Occitania! (1969) |
roge Lengadoc roge (1971) |
montsegur Montsegur! (1972) |
marti Marti (1972) |
viure;lo pais Lo pais que vol viure (1973) |
l'an L'an 01 (1975) |
camin Lo camin del solelh (1976) |
monta Monta vida (1980) |
tourne;pourtant Et pourtant elle tourne... (1992) |
jinete;el jinete El jinete (2002) |
tolosa Tolosa (2008) |
d'oc;homme Homme d'Oc (1974) |
claude marti;marti Claude Marti (1974) |
et lumiere;ombres Ombres et lumiere (1998) |
corbieres;au coeur Corbieres au coeur (1998) |
trencavel Trencavel (1999) |
carcassonne;au coeur Carcassonne au coeur (1999) |
au coeur;minervois Minervois au coeur (2002) |
l'eternel;l'olivier L'Olivier ou la resurrection de l'eternel (2003) |
the cowboys;buffaloes;ardor;stalwart;rams;asunder The Colorado State University Fight Song, known as "Stalwart Rams", is the official fight song for Colorado State University. Features of its uniqueness include the use of the word "stalwart," meaning unrelenting and full of ardor, and the third line of the song which allows the fight song to be adapted for each game, from "tear the Buffaloes line asunder" to "tear the Cowboys line asunder." |
yell;rams;csu The CSU Fight Song is commonly followed immediately by the "Spell Yell," a song in which the band and fans spell the word "Rams." |
bourne;aggies;colorado state rams;rams;aggie The "Colorado State University Fight Song" was written by Richard F. Bourne and first performed in 1932. The original lyrics were slightly different than the current ones, including the line "fight on ye stalwart aggies" as the Colorado State Rams were referred to as the Aggies during this time. Several other fight songs were used throughout the years such as the "Aggie Boom Song" which was adopted in 1937 as the official song of the Colorado A&M Aggies. The lyrics of the fight song were modified to include the newly adopted "Rams" name when Colorado A&M changed its name to Colorado State University in 1957. |
songa;aggie;yella;csu CSURams.comListen to the Colorado State University Fight SongThe CSU Fight Song and Spell YellA circa 1953 recording of the fight songA circa 1953 recording of the "Aggie Boom Song" |
clovelly;clovelly garden apartments;linde;nease;holman;the apartments The Clovelly Garden Apartments, also known as Holman Gardens, are a historic apartment complex located in northeast Portland, Oregon, United States. Built in 1928 in the Tudor Revival style, they are a fine example of the garden apartments popular in Portland in the late 1920s and early 1930s. They were designed by prominent architect Carl L. Linde (1864–1945) under commission to George Nease (1874–1958), an influential timber businessman. They contain light fixtures designed by Fred Baker (1887–1981), recognized as a master lighting designer in Portland in that period.The apartments were listed on the National Register of Historic Places in 1983. |
clovelly;clovelly garden apartments Media related to Clovelly Garden Apartments at Wikimedia Commons |
coalition chronicle Coalition Chronicle was a monthly, military magazine of stories and news briefs about military members in Iraq. It was produced by Multi-National Corps - Iraq (MNC-I) Public Affairs on Camp Victory, Iraq and has a distribution of exactly 10,000 copies throughout the Iraq theater of operations for coalition service members. It was the first-ever theater-wide magazine in Iraq dedicated to publishing information and stories representational of each country in the coalition serving in Iraq. |
freedom's;servicemembers;focal;memoriam The magazine published stories and photos highlighting missions and actions of servicemembers deployed to Iraq. Included in the magazine every month was a photo section, called "Freedom's Focal Point" which highlighted the best photos taken by military photographers in Iraq, and "In Memoriam", an updated monthly list of U.S. servicemembers who lost their lives in Iraq. |
baghdad;coalition chronicle The Coalition Chronicle was founded in 2006 by public affairs elements of the 82nd Airborne, who were acting as the major command stationed at Camp Victory, Baghdad, Iraq under the nomenclature Multi-National Corps - Iraq. |
coalition chronicle In 2008, the Coalition Chronicle was awarded 3rd place for Magazine format publication in the military-wide journalism awards, known as the Keith L. Ware Awards. Staff responsible for producing the content were members of the 28th Public Affairs Detachment, originally deployed from Fort Lewis, WA. |
coalition chronicle Coalition Chronicle was produced by MNC-I Public Affairs and the end of publication occurred during 2010, prior to the U.S. redeployment of forces from Iraq and the closing of Camp Victory in December 2010. |
colomoncagua;intibuca;honduran Colomoncagua (Spanish pronunciation: [kolomoŋˈkaɣwa]) is a municipality in the Honduran department of Intibuca. |
piedra;la piedra;pelon;colomoncagua;el cerro;piedra del;almanaque It is a municipality of much beauty known for its natural reserves. It is a safe place known for its hospitable residents. There is great meaning behind the name Colomoncagua, it refers to hills surrounded by water. Colomoncagua is surrounded by a vast expansion of pine trees. The climate is quite favorable year round. There are various tourist attractions as well, such as Chorreron Waterfall, La Piedra del Almanaque, El Cerro El Pelon, etc. Year round there are various cultural festivities. Colomoncagua is also known for its coffee and apples. |
lenca;colomoncagua;honduras;mestizo At the time of the 2013 Honduras census, Colomoncagua municipality had a population of 18,214. Of these, 97.07% were Mestizo, 1.87% Indigenous (1.75% Lenca), 0.96% White and 0.11% Afro-Honduran or Black. |
cologne;cologne grand prix The Cologne Grand Prix was a men's tennis tournament held in Cologne, West Germany, between 1976 and 1986. The tournament was a part of the Grand Prix tennis circuit for male tennis players and was played on indoor carpet courts. |
atp 1981 doubles results not included on ATP website |
cologne;cologne open Cologne Open (1992) |
rom;shack;symbolic;tandy;microsoft basic;beginner's;microsoft;color basic;the rom Color BASIC is the implementation of Microsoft BASIC that is included in the ROM of the Tandy/Radio Shack TRS-80 Color Computers manufactured between 1980 and 1991. BASIC (Beginner's All-purpose Symbolic Instruction Code) is a high level language with simple syntax that makes it easy to write simple programs. Color BASIC is interpreted, that is, decoded as it is run. |
rom;tandy;floppy disk controller;ecb;microsoft;color basic The nucleus of Color BASIC was Microsoft BASIC-69 which Tandy licensed from Microsoft. Color BASIC 1.0 was released with the original 4k TRS-80 Color Computer in 1980. It resides on 8k bytes of ROM, and is responsible for all housekeeping duties on the system. This includes hardware initialization, memory management, interrupt processing, etc. Like most implementations of BASIC, each line of code starts with a line number and consists of one or more statements with variables and operators. 16k of memory is required for the next level of BASIC, Extended Color BASIC. ("ECB") Extended BASIC is required for the floppy disk controller, which then gives you Disk Extended Color BASIC. ("DECB") Emulators of the Color Computers running this interpreter and the others are available for modern computers, some of which require a "snapshot" file of the physical machine. |
color basic Color BASIC understands one type of numeric variable and string variables. Variable names in Color BASIC have the first two characters significant. The first character of the variable name must be a letter. The second can be either a letter or number. String variables are indicated by adding a dollar sign ($) after the variable name. |
numeric Numeric variables have only one type, a binary floating point implementation. Each numeric variable uses 5 bytes of memory and can be in the range from -1E+38 up to 1E+37. |
color basic;microsoft basic;microsoft Unlike most implementations of Microsoft BASIC, Color BASIC requires the user to reserve space for string variables via the CLEAR statement. |
multidimensional Multidimensional arrays are also supported with both numeric and string variables. In the case of an array, the element address is enclosed with a parenthesis: |
commas Multiple dimensions are separated by commas |
color basic Color BASIC provides several operators for both mathematic and, to a lesser extent, string operations. |
semicolon A semicolon, when encountered in a PRINT function, will cause the output to remain on the same line |
color basic device number indicates a device. By default, device 0 (screen and keyboard) is assumed. In Color BASIC, device #-1 (cassette) and #-2 (printer) are available to the programmer. |
s';backspace;arrow keys;chars When in EDIT mode, you get a reprint of the line, and a second copy that you SPACEbar across chars. You cannot use arrow keys. backspace takes you left, but does not actually erase it in the buffer. i puts you in insert mode. pressing return gets you out of it. c changes one char, d deletes one char. x takes you to end of line, allowing you to e'x'tend it. l redraws the line. s searches for the next instance of a character. For the s', c and d commands you can also enter a number (#) before pressing any of them which will: s - search for the # instance of the character, c - allow you to change # of characters, d - delete # amount characters. |
abs ABS(num) |
asc ASC(str) |
ascii returns the ASCII code of the first character in str |
chr CHR$(num) |
ascii returns a single string character with the ASCII code num |
eof EOF(device number) |
int INT(num) |
len LEN(str) |
mem MEM |
peek PEEK(num) |
semigraphics;numm returns the color of the semigraphics dot at position x numm (0-63) and y num (0-31) |
rnd RND(number) |
sgn SGN(num) |
sin SIN(num) |
radians returns the sine of num in radians |
str STR$(num) |
usr USR(num) |
subroutine calls a machine language subroutine whose address is stored in memory locations 275 and 276. num is passed to the routine, and a return value is assigned when the routine is done |
cload CLOAD ["name"] |
color basic closes a device (in Color BASIC this can only be #-1, the cassette) |
cls CLS(num) |
cont CONT |
dim DIM variable(dimension[,dimension 2,...] |
exec EXEC |
gosub ON {num} GOSUB line 1, line 2, ... line n |
subroutine evaluates expression num and calls the numth subroutine listed |
goto ON (num) GOTO line 1, line 2, ... line n |
poke POKE memory address, data |
reset RESET(x,y) |
semigraphics sets the semigraphics pixel at location x (0-63) and y (0-31) to black |
subroutine returns from a subroutine |
semigraphics sets the semigraphics pixel at location x (0-63) y (0-31) to color (0-8) |
tab TAB(column) |
val VAL(str) |
gosub GOSUB {line number} |
subroutine calls the subroutine at the line number specified |
goto GOTO {line number} |
dim bad subscript. subscript is out of DIM range |
cont can't continue (see CONT command) |