id
stringlengths 15
15
| document_id
stringlengths 11
11
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
NCT02312089_exc | NCT02312089 | [
{
"id": "NCT02312089_exc_text",
"type": "exclusion",
"text": [
"Moderate or severe endometriosis.\nHydrosalpinx.\nUterine abnormalities.\nMyoma.\nPrevious uterine surgery.\n"
],
"offsets": [
[
0,
104
]
]
}
] | [
{
"id": "NCT02312089_exc_T1",
"type": "Condition",
"text": [
"endometriosis"
],
"offsets": [
[
19,
32
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T2",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
12,
18
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T3",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T4",
"type": "Scope",
"text": [
"Moderate or severe"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T5",
"type": "Condition",
"text": [
"Hydrosalpinx"
],
"offsets": [
[
34,
46
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T6",
"type": "Condition",
"text": [
"Uterine abnormalities"
],
"offsets": [
[
48,
69
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T7",
"type": "Condition",
"text": [
"Myoma"
],
"offsets": [
[
71,
76
]
],
"normalized": []
},
{
"id": "NCT02312089_exc_T8",
"type": "Procedure",
"text": [
"uterine surgery"
],
"offsets": [
[
87,
102
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02312089_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02312089_exc_T1",
"arg2_id": "NCT02312089_exc_T4",
"normalized": []
}
] |
NCT02312089_inc | NCT02312089 | [
{
"id": "NCT02312089_inc_text",
"type": "inclusion",
"text": [
"Women subjected to ICSI through controlled ovarian hyperstimulation (COH) with pituitary downregulation by GnRH antagonist.\n"
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "NCT02312089_inc_T1",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T2",
"type": "Procedure",
"text": [
"ICSI"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T3",
"type": "Procedure",
"text": [
"ovarian hyperstimulation"
],
"offsets": [
[
43,
67
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T4",
"type": "Procedure",
"text": [
"COH"
],
"offsets": [
[
69,
72
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T5",
"type": "Procedure",
"text": [
"pituitary downregulation"
],
"offsets": [
[
79,
103
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T6",
"type": "Procedure",
"text": [
"GnRH antagonist"
],
"offsets": [
[
107,
122
]
],
"normalized": []
},
{
"id": "NCT02312089_inc_T7",
"type": "Scope",
"text": [
"ovarian hyperstimulation (COH) with pituitary downregulation"
],
"offsets": [
[
43,
103
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02312089_inc_R1",
"type": "Subsumes",
"arg1_id": "NCT02312089_inc_T3",
"arg2_id": "NCT02312089_inc_T4",
"normalized": []
},
{
"id": "NCT02312089_inc_R2",
"type": "AND",
"arg1_id": "NCT02312089_inc_T2",
"arg2_id": "NCT02312089_inc_T6",
"normalized": []
},
{
"id": "NCT02312089_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02312089_inc_T6",
"arg2_id": "NCT02312089_inc_T7",
"normalized": []
}
] |
NCT02312960_exc | NCT02312960 | [
{
"id": "NCT02312960_exc_text",
"type": "exclusion",
"text": [
"Not applicable to this follow up study\n"
],
"offsets": [
[
0,
39
]
]
}
] | [] | [] | [] | [] |
NCT02312960_inc | NCT02312960 | [
{
"id": "NCT02312960_inc_text",
"type": "inclusion",
"text": [
"Subject was previously enrolled in a selected company sponsored feeder trial, and has received at least 1 dose of radium 223 dichloride or placebo in the feeder trial\n"
],
"offsets": [
[
0,
167
]
]
}
] | [] | [] | [] | [] |
NCT02314559_exc | NCT02314559 | [
{
"id": "NCT02314559_exc_text",
"type": "exclusion",
"text": [
"Dementia.\nGastroscopy planned at the same time.\nAllergies to propofol\nAll cases were a 'full stomach' is suspected (gastric banding)\nPregnancy\n"
],
"offsets": [
[
0,
143
]
]
}
] | [
{
"id": "NCT02314559_exc_T1",
"type": "Condition",
"text": [
"Dementia"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T2",
"type": "Procedure",
"text": [
"Gastroscopy"
],
"offsets": [
[
10,
21
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T3",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
22,
29
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T4",
"type": "Temporal",
"text": [
"at the same time"
],
"offsets": [
[
30,
46
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T5",
"type": "Condition",
"text": [
"Allergies"
],
"offsets": [
[
48,
57
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T6",
"type": "Drug",
"text": [
"propofol"
],
"offsets": [
[
61,
69
]
],
"normalized": []
},
{
"id": "NCT02314559_exc_T8",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
133,
142
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02314559_exc_R1",
"type": "Has_mood",
"arg1_id": "NCT02314559_exc_T2",
"arg2_id": "NCT02314559_exc_T3",
"normalized": []
},
{
"id": "NCT02314559_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02314559_exc_T2",
"arg2_id": "NCT02314559_exc_T4",
"normalized": []
},
{
"id": "NCT02314559_exc_R3",
"type": "AND",
"arg1_id": "NCT02314559_exc_T5",
"arg2_id": "NCT02314559_exc_T6",
"normalized": []
}
] |
NCT02314559_inc | NCT02314559 | [
{
"id": "NCT02314559_inc_text",
"type": "inclusion",
"text": [
"All patients subjected to deep sedation in ambulant care, having a colonoscopy\nASA 1-3\n"
],
"offsets": [
[
0,
87
]
]
}
] | [
{
"id": "NCT02314559_inc_T1",
"type": "Procedure",
"text": [
"deep sedation"
],
"offsets": [
[
26,
39
]
],
"normalized": []
},
{
"id": "NCT02314559_inc_T2",
"type": "Visit",
"text": [
"ambulant"
],
"offsets": [
[
43,
51
]
],
"normalized": []
},
{
"id": "NCT02314559_inc_T3",
"type": "Procedure",
"text": [
"colonoscopy"
],
"offsets": [
[
67,
78
]
],
"normalized": []
},
{
"id": "NCT02314559_inc_T4",
"type": "Measurement",
"text": [
"ASA"
],
"offsets": [
[
79,
82
]
],
"normalized": []
},
{
"id": "NCT02314559_inc_T5",
"type": "Value",
"text": [
"1-3"
],
"offsets": [
[
83,
86
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02314559_inc_R1",
"type": "AND",
"arg1_id": "NCT02314559_inc_T1",
"arg2_id": "NCT02314559_inc_T2",
"normalized": []
},
{
"id": "NCT02314559_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02314559_inc_T4",
"arg2_id": "NCT02314559_inc_T5",
"normalized": []
}
] |
NCT02315287_exc | NCT02315287 | [
{
"id": "NCT02315287_exc_text",
"type": "exclusion",
"text": [
"Contraindication to sitagliptin or metformin or thiazolidinedione\nPregnant or breast feeding women\nType 1 diabetes, gestational diabetes, or secondary forms of diabetes\nNot appropriate for oral antidiabetic agent\nMedication which affect glycemic control\nDisease which affect efficacy and safety of drugs\nAny major illness (Liver disease, Renal failure, Heart disease, Cancer, etc)\n"
],
"offsets": [
[
0,
381
]
]
}
] | [
{
"id": "NCT02315287_exc_T1",
"type": "Drug",
"text": [
"sitagliptin"
],
"offsets": [
[
20,
31
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T2",
"type": "Drug",
"text": [
"metformin"
],
"offsets": [
[
35,
44
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T3",
"type": "Drug",
"text": [
"thiazolidinedione"
],
"offsets": [
[
48,
65
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T4",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T5",
"type": "Scope",
"text": [
"sitagliptin or metformin or thiazolidinedione"
],
"offsets": [
[
20,
65
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T6",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
66,
74
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T7",
"type": "Condition",
"text": [
"breast"
],
"offsets": [
[
78,
84
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T8",
"type": "Condition",
"text": [
"Type 1 diabetes"
],
"offsets": [
[
99,
114
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T9",
"type": "Condition",
"text": [
"gestational diabetes"
],
"offsets": [
[
116,
136
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T10",
"type": "Condition",
"text": [
"secondary forms of diabetes"
],
"offsets": [
[
141,
168
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T11",
"type": "Negation",
"text": [
"Not"
],
"offsets": [
[
169,
172
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T12",
"type": "Observation",
"text": [
"appropriate"
],
"offsets": [
[
173,
184
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T13",
"type": "Drug",
"text": [
"oral antidiabetic agent"
],
"offsets": [
[
189,
212
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T14",
"type": "Drug",
"text": [
"Medication"
],
"offsets": [
[
213,
223
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T15",
"type": "Observation",
"text": [
"affect glycemic control"
],
"offsets": [
[
230,
253
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T16",
"type": "Drug",
"text": [
"Disease"
],
"offsets": [
[
254,
261
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T17",
"type": "Qualifier",
"text": [
"affect efficacy"
],
"offsets": [
[
268,
283
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T18",
"type": "Qualifier",
"text": [
"safety of drugs"
],
"offsets": [
[
288,
303
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T19",
"type": "Scope",
"text": [
"affect efficacy and safety of drugs"
],
"offsets": [
[
268,
303
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T20",
"type": "Condition",
"text": [
"major illness"
],
"offsets": [
[
308,
321
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T21",
"type": "Condition",
"text": [
"Liver disease"
],
"offsets": [
[
323,
336
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T22",
"type": "Condition",
"text": [
"Renal failure"
],
"offsets": [
[
338,
351
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T23",
"type": "Condition",
"text": [
"Heart disease"
],
"offsets": [
[
353,
366
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T24",
"type": "Condition",
"text": [
"Cancer"
],
"offsets": [
[
368,
374
]
],
"normalized": []
},
{
"id": "NCT02315287_exc_T25",
"type": "Scope",
"text": [
"Liver disease, Renal failure, Heart disease, Cancer"
],
"offsets": [
[
323,
374
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02315287_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02315287_exc_T4",
"arg2_id": "NCT02315287_exc_T5",
"normalized": []
},
{
"id": "NCT02315287_exc_R2",
"type": "AND",
"arg1_id": "NCT02315287_exc_T12",
"arg2_id": "NCT02315287_exc_T13",
"normalized": []
},
{
"id": "NCT02315287_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02315287_exc_T12",
"arg2_id": "NCT02315287_exc_T11",
"normalized": []
},
{
"id": "NCT02315287_exc_R4",
"type": "AND",
"arg1_id": "NCT02315287_exc_T15",
"arg2_id": "NCT02315287_exc_T14",
"normalized": []
},
{
"id": "NCT02315287_exc_R5",
"type": "Has_scope",
"arg1_id": "NCT02315287_exc_T16",
"arg2_id": "NCT02315287_exc_T19",
"normalized": []
},
{
"id": "NCT02315287_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02315287_exc_T20",
"arg2_id": "NCT02315287_exc_T25",
"normalized": []
}
] |
NCT02315287_inc | NCT02315287 | [
{
"id": "NCT02315287_inc_text",
"type": "inclusion",
"text": [
"HbA1c > 13.0 %\nNo treatment with insulin or oral agents for 6 months\n20 = Age < 80 years\n"
],
"offsets": [
[
0,
89
]
]
}
] | [
{
"id": "NCT02315287_inc_T1",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T2",
"type": "Value",
"text": [
"> 13.0 %"
],
"offsets": [
[
6,
14
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T3",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
15,
17
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T4",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
18,
27
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T5",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
33,
40
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T6",
"type": "Drug",
"text": [
"oral agents"
],
"offsets": [
[
44,
55
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T7",
"type": "Temporal",
"text": [
"for 6 months"
],
"offsets": [
[
56,
68
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T8",
"type": "Scope",
"text": [
"insulin or oral agents"
],
"offsets": [
[
33,
55
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T9",
"type": "Value",
"text": [
"20 ="
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T10",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
74,
77
]
],
"normalized": []
},
{
"id": "NCT02315287_inc_T11",
"type": "Value",
"text": [
"< 80 years"
],
"offsets": [
[
78,
88
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02315287_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02315287_inc_T1",
"arg2_id": "NCT02315287_inc_T2",
"normalized": []
},
{
"id": "NCT02315287_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02315287_inc_T4",
"arg2_id": "NCT02315287_inc_T8",
"normalized": []
},
{
"id": "NCT02315287_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02315287_inc_T8",
"arg2_id": "NCT02315287_inc_T7",
"normalized": []
},
{
"id": "NCT02315287_inc_R4",
"type": "Has_negation",
"arg1_id": "NCT02315287_inc_T4",
"arg2_id": "NCT02315287_inc_T3",
"normalized": []
},
{
"id": "NCT02315287_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02315287_inc_T10",
"arg2_id": "NCT02315287_inc_T9",
"normalized": []
}
] |
NCT02316886_exc | NCT02316886 | [
{
"id": "NCT02316886_exc_text",
"type": "exclusion",
"text": [
"Patients in whom the preferred treatment is CABG(Coronary artery bypass grafting)\nStented lesion\nBypass graft lesion\nThe patients who have more than or equal to 3 target lesions\n2 target lesions in the same coronary territory\nHeavily calcified or angulated lesion\nBifurcation lesion requiring 2 stenting technique\nContraindication to or planned discontinuation of dual antiplatelet therapy within 1 year\nLife expectancy less than 2 years\nPlanned cardiac surgery or planned major non cardiac surgery\nWoman who are breastfeeding, pregnant or planning to become pregnant during the course of the study\n"
],
"offsets": [
[
0,
599
]
]
}
] | [
{
"id": "NCT02316886_exc_T1",
"type": "Device",
"text": [
"Stented"
],
"offsets": [
[
82,
89
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T2",
"type": "Condition",
"text": [
"lesion"
],
"offsets": [
[
90,
96
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T3",
"type": "Procedure",
"text": [
"CABG"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T4",
"type": "Procedure",
"text": [
"Coronary artery bypass grafting"
],
"offsets": [
[
49,
80
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T5",
"type": "Device",
"text": [
"Bypass graft"
],
"offsets": [
[
97,
109
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T6",
"type": "Condition",
"text": [
"lesion"
],
"offsets": [
[
110,
116
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T7",
"type": "Multiplier",
"text": [
"more than or equal to 3"
],
"offsets": [
[
139,
162
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T8",
"type": "Condition",
"text": [
"target lesions"
],
"offsets": [
[
163,
177
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T9",
"type": "Multiplier",
"text": [
"2"
],
"offsets": [
[
178,
179
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T10",
"type": "Condition",
"text": [
"target lesions"
],
"offsets": [
[
180,
194
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T11",
"type": "Qualifier",
"text": [
"in the same coronary territory"
],
"offsets": [
[
195,
225
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T12",
"type": "Qualifier",
"text": [
"Heavily calcified"
],
"offsets": [
[
226,
243
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T13",
"type": "Qualifier",
"text": [
"angulated"
],
"offsets": [
[
247,
256
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T14",
"type": "Condition",
"text": [
"lesion"
],
"offsets": [
[
257,
263
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T15",
"type": "Scope",
"text": [
"Heavily calcified or angulated"
],
"offsets": [
[
226,
256
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T16",
"type": "Condition",
"text": [
"Bifurcation lesion"
],
"offsets": [
[
264,
282
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T17",
"type": "Multiplier",
"text": [
"2"
],
"offsets": [
[
293,
294
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T18",
"type": "Procedure",
"text": [
"stenting technique"
],
"offsets": [
[
295,
313
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T19",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
314,
330
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T20",
"type": "Mood",
"text": [
"planned discontinuation"
],
"offsets": [
[
337,
360
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T21",
"type": "Procedure",
"text": [
"dual antiplatelet therapy"
],
"offsets": [
[
364,
389
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T22",
"type": "Temporal",
"text": [
"within 1 year"
],
"offsets": [
[
390,
403
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T23",
"type": "Scope",
"text": [
"Contraindication to or planned discontinuation"
],
"offsets": [
[
314,
360
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T24",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
404,
419
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T25",
"type": "Value",
"text": [
"less than 2 years"
],
"offsets": [
[
420,
437
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T26",
"type": "Procedure",
"text": [
"cardiac surgery"
],
"offsets": [
[
446,
461
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T27",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
465,
472
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T28",
"type": "Mood",
"text": [
"Planned"
],
"offsets": [
[
438,
445
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T29",
"type": "Qualifier",
"text": [
"major"
],
"offsets": [
[
473,
478
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T30",
"type": "Procedure",
"text": [
"non cardiac surgery"
],
"offsets": [
[
479,
498
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T31",
"type": "Person",
"text": [
"Woman"
],
"offsets": [
[
499,
504
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T32",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
513,
526
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T33",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
528,
536
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T34",
"type": "Mood",
"text": [
"planning to become"
],
"offsets": [
[
540,
558
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T35",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
559,
567
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T36",
"type": "Temporal",
"text": [
"during the course of the study"
],
"offsets": [
[
568,
598
]
],
"normalized": []
},
{
"id": "NCT02316886_exc_T37",
"type": "Scope",
"text": [
"breastfeeding, pregnant or planning to become pregnant"
],
"offsets": [
[
513,
567
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02316886_exc_R1",
"type": "AND",
"arg1_id": "NCT02316886_exc_T2",
"arg2_id": "NCT02316886_exc_T1",
"normalized": []
},
{
"id": "NCT02316886_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02316886_exc_T3",
"arg2_id": "NCT02316886_exc_T4",
"normalized": []
},
{
"id": "NCT02316886_exc_R3",
"type": "AND",
"arg1_id": "NCT02316886_exc_T6",
"arg2_id": "NCT02316886_exc_T5",
"normalized": []
},
{
"id": "NCT02316886_exc_R4",
"type": "Has_multiplier",
"arg1_id": "NCT02316886_exc_T8",
"arg2_id": "NCT02316886_exc_T7",
"normalized": []
},
{
"id": "NCT02316886_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02316886_exc_T10",
"arg2_id": "NCT02316886_exc_T11",
"normalized": []
},
{
"id": "NCT02316886_exc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02316886_exc_T10",
"arg2_id": "NCT02316886_exc_T9",
"normalized": []
},
{
"id": "NCT02316886_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT02316886_exc_T14",
"arg2_id": "NCT02316886_exc_T15",
"normalized": []
},
{
"id": "NCT02316886_exc_R8",
"type": "Has_multiplier",
"arg1_id": "NCT02316886_exc_T18",
"arg2_id": "NCT02316886_exc_T17",
"normalized": []
},
{
"id": "NCT02316886_exc_R9",
"type": "AND",
"arg1_id": "NCT02316886_exc_T16",
"arg2_id": "NCT02316886_exc_T18",
"normalized": []
},
{
"id": "NCT02316886_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02316886_exc_T21",
"arg2_id": "NCT02316886_exc_T23",
"normalized": []
},
{
"id": "NCT02316886_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02316886_exc_T21",
"arg2_id": "NCT02316886_exc_T22",
"normalized": []
},
{
"id": "NCT02316886_exc_R12",
"type": "Has_value",
"arg1_id": "NCT02316886_exc_T24",
"arg2_id": "NCT02316886_exc_T25",
"normalized": []
},
{
"id": "NCT02316886_exc_R13",
"type": "Has_mood",
"arg1_id": "NCT02316886_exc_T26",
"arg2_id": "NCT02316886_exc_T28",
"normalized": []
},
{
"id": "NCT02316886_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02316886_exc_T30",
"arg2_id": "NCT02316886_exc_T29",
"normalized": []
},
{
"id": "NCT02316886_exc_R15",
"type": "Has_mood",
"arg1_id": "NCT02316886_exc_T30",
"arg2_id": "NCT02316886_exc_T27",
"normalized": []
},
{
"id": "NCT02316886_exc_R16",
"type": "Has_mood",
"arg1_id": "NCT02316886_exc_T35",
"arg2_id": "NCT02316886_exc_T34",
"normalized": []
},
{
"id": "NCT02316886_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT02316886_exc_T37",
"arg2_id": "NCT02316886_exc_T36",
"normalized": []
}
] |
NCT02316886_inc | NCT02316886 | [
{
"id": "NCT02316886_inc_text",
"type": "inclusion",
"text": [
"Age 18 years or older\nSymptomatic or asymptomatic coronary artery disease patients\nMLA(minimal luminal area)<4mm2\nplaque burden>70%\nLipid-rich plaque on NIRS(Intracoronary Near-Infrared Spectroscopy) (defined as maxLCBI4mm>315)\n2 target vulnerable lesions\nEligible for percutaneous coronary intervention with Absorb Bioresorbable Vascular Scaffold or Everolimus Eluting Stent\nWilling and able to provide informed written consent\nReference vessel diameter 2.75-4.0\nLesion length = 40\n"
],
"offsets": [
[
0,
483
]
]
}
] | [
{
"id": "NCT02316886_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T2",
"type": "Value",
"text": [
"18 years or older"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T3",
"type": "Qualifier",
"text": [
"asymptomatic"
],
"offsets": [
[
37,
49
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T4",
"type": "Condition",
"text": [
"coronary artery disease"
],
"offsets": [
[
50,
73
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T5",
"type": "Qualifier",
"text": [
"Symptomatic"
],
"offsets": [
[
22,
33
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T6",
"type": "Scope",
"text": [
"Symptomatic or asymptomatic"
],
"offsets": [
[
22,
49
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T7",
"type": "Measurement",
"text": [
"MLA"
],
"offsets": [
[
83,
86
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T8",
"type": "Measurement",
"text": [
"minimal luminal area"
],
"offsets": [
[
87,
107
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T9",
"type": "Value",
"text": [
"<4mm2"
],
"offsets": [
[
108,
113
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T10",
"type": "Measurement",
"text": [
"plaque burden"
],
"offsets": [
[
114,
127
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T11",
"type": "Value",
"text": [
">70%"
],
"offsets": [
[
127,
131
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T12",
"type": "Condition",
"text": [
"Lipid-rich plaque"
],
"offsets": [
[
132,
149
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T13",
"type": "Procedure",
"text": [
"NIRS"
],
"offsets": [
[
153,
157
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T14",
"type": "Procedure",
"text": [
"Intracoronary Near-Infrared Spectroscopy"
],
"offsets": [
[
158,
198
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T15",
"type": "Measurement",
"text": [
"maxLCBI4mm"
],
"offsets": [
[
212,
222
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T16",
"type": "Value",
"text": [
">315"
],
"offsets": [
[
222,
226
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T17",
"type": "Multiplier",
"text": [
"2"
],
"offsets": [
[
228,
229
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T18",
"type": "Condition",
"text": [
"target vulnerable lesions"
],
"offsets": [
[
230,
255
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T19",
"type": "Mood",
"text": [
"Eligible for"
],
"offsets": [
[
256,
268
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T20",
"type": "Procedure",
"text": [
"percutaneous coronary intervention"
],
"offsets": [
[
269,
303
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T21",
"type": "Device",
"text": [
"Absorb Bioresorbable Vascular Scaffold"
],
"offsets": [
[
309,
347
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T22",
"type": "Device",
"text": [
"Everolimus Eluting Stent"
],
"offsets": [
[
351,
375
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T23",
"type": "Scope",
"text": [
"Absorb Bioresorbable Vascular Scaffold or Everolimus Eluting Stent"
],
"offsets": [
[
309,
375
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T25",
"type": "Measurement",
"text": [
"Reference vessel diameter"
],
"offsets": [
[
429,
454
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T26",
"type": "Value",
"text": [
"2.75-4.0"
],
"offsets": [
[
455,
463
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T27",
"type": "Measurement",
"text": [
"Lesion length"
],
"offsets": [
[
464,
477
]
],
"normalized": []
},
{
"id": "NCT02316886_inc_T28",
"type": "Value",
"text": [
"= 40"
],
"offsets": [
[
478,
482
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02316886_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02316886_inc_T1",
"arg2_id": "NCT02316886_inc_T2",
"normalized": []
},
{
"id": "NCT02316886_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02316886_inc_T4",
"arg2_id": "NCT02316886_inc_T6",
"normalized": []
},
{
"id": "NCT02316886_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02316886_inc_T7",
"arg2_id": "NCT02316886_inc_T8",
"normalized": []
},
{
"id": "NCT02316886_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02316886_inc_T7",
"arg2_id": "NCT02316886_inc_T9",
"normalized": []
},
{
"id": "NCT02316886_inc_R5",
"type": "Subsumes",
"arg1_id": "NCT02316886_inc_T13",
"arg2_id": "NCT02316886_inc_T14",
"normalized": []
},
{
"id": "NCT02316886_inc_R6",
"type": "AND",
"arg1_id": "NCT02316886_inc_T13",
"arg2_id": "NCT02316886_inc_T12",
"normalized": []
},
{
"id": "NCT02316886_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02316886_inc_T15",
"arg2_id": "NCT02316886_inc_T16",
"normalized": []
},
{
"id": "NCT02316886_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02316886_inc_T12",
"arg2_id": "NCT02316886_inc_T15",
"normalized": []
},
{
"id": "NCT02316886_inc_R9",
"type": "Has_multiplier",
"arg1_id": "NCT02316886_inc_T18",
"arg2_id": "NCT02316886_inc_T17",
"normalized": []
},
{
"id": "NCT02316886_inc_R10",
"type": "Has_mood",
"arg1_id": "NCT02316886_inc_T20",
"arg2_id": "NCT02316886_inc_T19",
"normalized": []
},
{
"id": "NCT02316886_inc_R11",
"type": "Has_scope",
"arg1_id": "NCT02316886_inc_T20",
"arg2_id": "NCT02316886_inc_T23",
"normalized": []
},
{
"id": "NCT02316886_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02316886_inc_T25",
"arg2_id": "NCT02316886_inc_T26",
"normalized": []
},
{
"id": "NCT02316886_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02316886_inc_T27",
"arg2_id": "NCT02316886_inc_T28",
"normalized": []
}
] |
NCT02318446_exc | NCT02318446 | [
{
"id": "NCT02318446_exc_text",
"type": "exclusion",
"text": [
"Pregnancy and lactation \nPatients with diabetes, Ischemic heart disease (IHD), stroke, malignancy and psychiatric diseases are excluded from study. \nThe patients receiving vitamin supplements or who had clinical evidence for an acute illness, renal dysfunction, thyroid dysfunction, chronic inflammatory diseases, inborn errors of homocysteine, cobalamin or folate metabolism, or any other condition known to interfere with homocysteine metabolism will be excluded \nPatients who are already involved in any other trial. \nPatients not willing to fill consent/ assent form are also excluded from study. \n \n"
],
"offsets": [
[
0,
613
]
]
}
] | [
{
"id": "NCT02318446_exc_T1",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T2",
"type": "Condition",
"text": [
"lactation"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T4",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
39,
47
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T5",
"type": "Condition",
"text": [
"Ischemic heart disease (IHD)"
],
"offsets": [
[
49,
77
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T6",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
79,
85
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T7",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
87,
97
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T8",
"type": "Condition",
"text": [
"psychiatric diseases"
],
"offsets": [
[
102,
122
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T10",
"type": "Drug",
"text": [
"vitamin supplements"
],
"offsets": [
[
172,
191
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T11",
"type": "Condition",
"text": [
"clinical evidence for an acute illness"
],
"offsets": [
[
203,
241
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T12",
"type": "Condition",
"text": [
"acute illness"
],
"offsets": [
[
228,
241
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T14",
"type": "Condition",
"text": [
"renal dysfunction"
],
"offsets": [
[
243,
260
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T15",
"type": "Condition",
"text": [
"thyroid dysfunction"
],
"offsets": [
[
262,
281
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T16",
"type": "Condition",
"text": [
"chronic inflammatory diseases"
],
"offsets": [
[
283,
312
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T17",
"type": "Condition",
"text": [
"inborn errors of homocysteine",
"metabolism"
],
"offsets": [
[
314,
343
],
[
365,
375
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T18",
"type": "Condition",
"text": [
"inborn errors of",
"folate metabolism"
],
"offsets": [
[
314,
330
],
[
358,
375
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T19",
"type": "Condition",
"text": [
"inborn errors of",
"cobalamin",
"metabolism"
],
"offsets": [
[
314,
330
],
[
345,
354
],
[
365,
375
]
],
"normalized": []
},
{
"id": "NCT02318446_exc_T20",
"type": "Condition",
"text": [
"condition known to interfere with homocysteine metabolism"
],
"offsets": [
[
390,
447
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02318446_exc_R1",
"type": "AND",
"arg1_id": "NCT02318446_exc_T11",
"arg2_id": "NCT02318446_exc_T12",
"normalized": []
}
] |
NCT02318446_inc | NCT02318446 | [
{
"id": "NCT02318446_inc_text",
"type": "inclusion",
"text": [
"Diagnosed epileptic patients of either sex with age between 10-19 yrs (<19yrs), coming to the medicine Out Patient /In Patient Departments and undergoing AED therapy for more than 6 months. \nEpileptics with high homocysteine levels i.e. > 10.9 µmol/L (Normal homocysteine levels are 4.3-9.9 µmol/L for male and 3.3-7.2 µmol/L for female adolescent and a high homocysteine concentration is deaned as at least 11.4 µmol/L for male and at least 10.4 µmol/L for female. Gender mean of high homocysteine concentration is 10.9 µmol/L) [5] \n"
],
"offsets": [
[
0,
534
]
]
}
] | [
{
"id": "NCT02318446_inc_T1",
"type": "Condition",
"text": [
"epileptic"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
48,
51
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T3",
"type": "Value",
"text": [
"between 10-19 yrs"
],
"offsets": [
[
52,
69
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T4",
"type": "Value",
"text": [
"<19yrs"
],
"offsets": [
[
71,
77
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T5",
"type": "Visit",
"text": [
"Out Patient",
"Departments"
],
"offsets": [
[
103,
114
],
[
127,
138
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T6",
"type": "Visit",
"text": [
"In Patient Departments"
],
"offsets": [
[
116,
138
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T7",
"type": "Procedure",
"text": [
"AED therapy"
],
"offsets": [
[
154,
165
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T8",
"type": "Temporal",
"text": [
"for more than 6 months"
],
"offsets": [
[
166,
188
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T9",
"type": "Measurement",
"text": [
"homocysteine levels"
],
"offsets": [
[
212,
231
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T10",
"type": "Value",
"text": [
"high"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "NCT02318446_inc_T11",
"type": "Value",
"text": [
"> 10.9 µmol/L"
],
"offsets": [
[
237,
250
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02318446_inc_R1",
"type": "Subsumes",
"arg1_id": "NCT02318446_inc_T3",
"arg2_id": "NCT02318446_inc_T4",
"normalized": []
},
{
"id": "NCT02318446_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02318446_inc_T7",
"arg2_id": "NCT02318446_inc_T8",
"normalized": []
},
{
"id": "NCT02318446_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02318446_inc_T2",
"arg2_id": "NCT02318446_inc_T3",
"normalized": []
},
{
"id": "NCT02318446_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02318446_inc_T9",
"arg2_id": "NCT02318446_inc_T10",
"normalized": []
},
{
"id": "NCT02318446_inc_R5",
"type": "Subsumes",
"arg1_id": "NCT02318446_inc_T10",
"arg2_id": "NCT02318446_inc_T11",
"normalized": []
}
] |
NCT02321202_exc | NCT02321202 | [
{
"id": "NCT02321202_exc_text",
"type": "exclusion",
"text": [
"Contraindication for hepatectomy, including gastrointestinal hemorrhage, severe hemorrhagic disorders, explicit acute nonspecific infectious lesion, overt ascites, Child-Pugh Score C, indocyanine green retention rate at 15min (ICGR15)＞30%(12), serum hepatitis B virus (HBV)-DNA＞126 copies/ml and serum alanine aminotransferase (ALT) ＞ 2×ULN, serum triglycerides＞2.0 mmol/L, circulatory shock, stroke, acute myocardial infarction, renal failure, coma of unknown cause \nPregnancy \nAge of＜18y or＞75y \nPerformed intraoperative ablation \nUnresectable tumor during operation \nAllergic reactions against fish or egg proteins \n \n"
],
"offsets": [
[
0,
630
]
]
}
] | [
{
"id": "NCT02321202_exc_T1",
"type": "Condition",
"text": [
"Contraindication for hepatectomy"
],
"offsets": [
[
0,
32
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T2",
"type": "Condition",
"text": [
"gastrointestinal hemorrhage"
],
"offsets": [
[
44,
71
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T3",
"type": "Condition",
"text": [
"hemorrhagic disorders"
],
"offsets": [
[
80,
101
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T4",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T5",
"type": "Condition",
"text": [
"infectious lesion"
],
"offsets": [
[
130,
147
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T6",
"type": "Qualifier",
"text": [
"nonspecific"
],
"offsets": [
[
118,
129
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T7",
"type": "Temporal",
"text": [
"acute"
],
"offsets": [
[
112,
117
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T8",
"type": "Condition",
"text": [
"ascites"
],
"offsets": [
[
155,
162
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T9",
"type": "Qualifier",
"text": [
"overt"
],
"offsets": [
[
149,
154
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T10",
"type": "Measurement",
"text": [
"Child-Pugh Score"
],
"offsets": [
[
164,
180
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T11",
"type": "Value",
"text": [
"C"
],
"offsets": [
[
181,
182
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T12",
"type": "Measurement",
"text": [
"indocyanine green retention rate at 15min (ICGR15)"
],
"offsets": [
[
184,
234
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T13",
"type": "Value",
"text": [
"＞30%"
],
"offsets": [
[
234,
238
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T14",
"type": "Measurement",
"text": [
"serum hepatitis B virus (HBV)-DNA"
],
"offsets": [
[
244,
277
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T15",
"type": "Value",
"text": [
"＞126 copies/ml"
],
"offsets": [
[
277,
291
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T16",
"type": "Measurement",
"text": [
"serum alanine aminotransferase (ALT)"
],
"offsets": [
[
296,
332
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T17",
"type": "Value",
"text": [
"＞ 2×ULN"
],
"offsets": [
[
333,
340
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T18",
"type": "Measurement",
"text": [
"serum triglycerides"
],
"offsets": [
[
342,
361
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T19",
"type": "Value",
"text": [
"＞2.0 mmol/L"
],
"offsets": [
[
361,
372
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T20",
"type": "Condition",
"text": [
"circulatory shock"
],
"offsets": [
[
374,
391
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T21",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
393,
399
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T22",
"type": "Condition",
"text": [
"acute myocardial infarction"
],
"offsets": [
[
401,
428
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T23",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
430,
443
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T24",
"type": "Condition",
"text": [
"coma"
],
"offsets": [
[
445,
449
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T25",
"type": "Qualifier",
"text": [
"unknown cause"
],
"offsets": [
[
453,
466
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T26",
"type": "Scope",
"text": [
"gastrointestinal hemorrhage, severe hemorrhagic disorders, explicit acute nonspecific infectious lesion, overt ascites, Child-Pugh Score C, indocyanine green retention rate at 15min (ICGR15)＞30%(12), serum hepatitis B virus (HBV)-DNA＞126 copies/ml and serum alanine aminotransferase (ALT) ＞ 2×ULN, serum triglycerides＞2.0 mmol/L, circulatory shock, stroke, acute myocardial infarction, renal failure, coma of unknown cause"
],
"offsets": [
[
44,
466
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T27",
"type": "Procedure",
"text": [
"hepatectomy"
],
"offsets": [
[
21,
32
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T28",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
468,
477
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T29",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
479,
482
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T30",
"type": "Value",
"text": [
"＜18y or＞75y"
],
"offsets": [
[
485,
496
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T31",
"type": "Procedure",
"text": [
"intraoperative ablation"
],
"offsets": [
[
508,
531
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T32",
"type": "Condition",
"text": [
"Unresectable tumor"
],
"offsets": [
[
533,
551
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T33",
"type": "Drug",
"text": [
"fish",
"proteins"
],
"offsets": [
[
597,
601
],
[
609,
617
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T34",
"type": "Drug",
"text": [
"egg proteins"
],
"offsets": [
[
605,
617
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T35",
"type": "Condition",
"text": [
"Allergic reactions"
],
"offsets": [
[
570,
588
]
],
"normalized": []
},
{
"id": "NCT02321202_exc_T36",
"type": "Scope",
"text": [
"fish or egg proteins"
],
"offsets": [
[
597,
617
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02321202_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02321202_exc_T3",
"arg2_id": "NCT02321202_exc_T4",
"normalized": []
},
{
"id": "NCT02321202_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02321202_exc_T5",
"arg2_id": "NCT02321202_exc_T6",
"normalized": []
},
{
"id": "NCT02321202_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02321202_exc_T5",
"arg2_id": "NCT02321202_exc_T7",
"normalized": []
},
{
"id": "NCT02321202_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02321202_exc_T8",
"arg2_id": "NCT02321202_exc_T9",
"normalized": []
},
{
"id": "NCT02321202_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T10",
"arg2_id": "NCT02321202_exc_T11",
"normalized": []
},
{
"id": "NCT02321202_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T12",
"arg2_id": "NCT02321202_exc_T13",
"normalized": []
},
{
"id": "NCT02321202_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T16",
"arg2_id": "NCT02321202_exc_T17",
"normalized": []
},
{
"id": "NCT02321202_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T18",
"arg2_id": "NCT02321202_exc_T19",
"normalized": []
},
{
"id": "NCT02321202_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02321202_exc_T24",
"arg2_id": "NCT02321202_exc_T25",
"normalized": []
},
{
"id": "NCT02321202_exc_R10",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T14",
"arg2_id": "NCT02321202_exc_T15",
"normalized": []
},
{
"id": "NCT02321202_exc_R11",
"type": "Subsumes",
"arg1_id": "NCT02321202_exc_T1",
"arg2_id": "NCT02321202_exc_T26",
"normalized": []
},
{
"id": "NCT02321202_exc_R12",
"type": "AND",
"arg1_id": "NCT02321202_exc_T1",
"arg2_id": "NCT02321202_exc_T27",
"normalized": []
},
{
"id": "NCT02321202_exc_R13",
"type": "Has_value",
"arg1_id": "NCT02321202_exc_T29",
"arg2_id": "NCT02321202_exc_T30",
"normalized": []
},
{
"id": "NCT02321202_exc_R14",
"type": "Has_scope",
"arg1_id": "NCT02321202_exc_T35",
"arg2_id": "NCT02321202_exc_T36",
"normalized": []
}
] |
NCT02321202_inc | NCT02321202 | [
{
"id": "NCT02321202_inc_text",
"type": "inclusion",
"text": [
"The cirrhotic malnourished patients who were diagnosed as liver cancer preoperatively and underwent hepatectomy were consecutively enrolled. \n"
],
"offsets": [
[
0,
142
]
]
}
] | [
{
"id": "NCT02321202_inc_T1",
"type": "Condition",
"text": [
"cirrhotic"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "NCT02321202_inc_T2",
"type": "Condition",
"text": [
"malnourished"
],
"offsets": [
[
14,
26
]
],
"normalized": []
},
{
"id": "NCT02321202_inc_T3",
"type": "Condition",
"text": [
"liver cancer"
],
"offsets": [
[
58,
70
]
],
"normalized": []
},
{
"id": "NCT02321202_inc_T4",
"type": "Temporal",
"text": [
"preoperatively"
],
"offsets": [
[
71,
85
]
],
"normalized": []
},
{
"id": "NCT02321202_inc_T5",
"type": "Procedure",
"text": [
"hepatectomy"
],
"offsets": [
[
100,
111
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02321202_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02321202_inc_T3",
"arg2_id": "NCT02321202_inc_T4",
"normalized": []
}
] |
NCT02321839_exc | NCT02321839 | [
{
"id": "NCT02321839_exc_text",
"type": "exclusion",
"text": [
"Total lesion area of >12 DA or >30.5 mm2\nThe existence of subretinal hemorrhage area constituting =50% of total lesion area\nThe existence of scar or fibrosis area constituting =50% of total lesion area\nThe existence of RPE tear\nPrior treatment for wet AMD\nHistory of vitrectomy surgery, submacular surgery, or other surgical intervention for AMD\nThe pregnant or lactating woman\n"
],
"offsets": [
[
0,
378
]
]
}
] | [
{
"id": "NCT02321839_exc_T1",
"type": "Measurement",
"text": [
"Total lesion area"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T2",
"type": "Value",
"text": [
">12 DA"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T3",
"type": "Value",
"text": [
">30.5 mm2"
],
"offsets": [
[
31,
40
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T4",
"type": "Scope",
"text": [
">12 DA or >30.5 mm2"
],
"offsets": [
[
21,
40
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T5",
"type": "Measurement",
"text": [
"subretinal hemorrhage area"
],
"offsets": [
[
58,
84
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T6",
"type": "Value",
"text": [
"=50% of total lesion area"
],
"offsets": [
[
98,
123
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T7",
"type": "Measurement",
"text": [
"ar o",
"ea c"
],
"offsets": [
[
143,
147
],
[
160,
164
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T8",
"type": "Measurement",
"text": [
"fibrosis area"
],
"offsets": [
[
149,
162
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T9",
"type": "Scope",
"text": [
"scar or fibrosis area"
],
"offsets": [
[
141,
162
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T10",
"type": "Value",
"text": [
"=50% of total lesion area"
],
"offsets": [
[
176,
201
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T11",
"type": "Condition",
"text": [
"RPE tear"
],
"offsets": [
[
219,
227
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T12",
"type": "Temporal",
"text": [
"Prior"
],
"offsets": [
[
228,
233
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T13",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
234,
243
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T14",
"type": "Procedure",
"text": [
"vitrectomy surgery"
],
"offsets": [
[
267,
285
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T15",
"type": "Procedure",
"text": [
"submacular surgery"
],
"offsets": [
[
287,
305
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T16",
"type": "Procedure",
"text": [
"surgical intervention"
],
"offsets": [
[
316,
337
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T17",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
310,
315
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T18",
"type": "Condition",
"text": [
"AMD"
],
"offsets": [
[
342,
345
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T19",
"type": "Scope",
"text": [
"vitrectomy surgery, submacular surgery, or other surgical intervention"
],
"offsets": [
[
267,
337
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T20",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
350,
358
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T21",
"type": "Condition",
"text": [
"lactating"
],
"offsets": [
[
362,
371
]
],
"normalized": []
},
{
"id": "NCT02321839_exc_T22",
"type": "Person",
"text": [
"woman"
],
"offsets": [
[
372,
377
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02321839_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02321839_exc_T1",
"arg2_id": "NCT02321839_exc_T4",
"normalized": []
},
{
"id": "NCT02321839_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02321839_exc_T5",
"arg2_id": "NCT02321839_exc_T6",
"normalized": []
},
{
"id": "NCT02321839_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02321839_exc_T9",
"arg2_id": "NCT02321839_exc_T10",
"normalized": []
},
{
"id": "NCT02321839_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02321839_exc_T16",
"arg2_id": "NCT02321839_exc_T17",
"normalized": []
},
{
"id": "NCT02321839_exc_R5",
"type": "AND",
"arg1_id": "NCT02321839_exc_T19",
"arg2_id": "NCT02321839_exc_T18",
"normalized": []
}
] |
NCT02321839_inc | NCT02321839 | [
{
"id": "NCT02321839_inc_text",
"type": "inclusion",
"text": [
"Signed informed consent form\nMale or female of aged 50 years or older\nTypical AMD and PCV patients\nBCVA of 24 letters or over\n"
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "NCT02321839_inc_T2",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T3",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T4",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T5",
"type": "Value",
"text": [
"50 years or older"
],
"offsets": [
[
52,
69
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T6",
"type": "Condition",
"text": [
"PCV patients"
],
"offsets": [
[
86,
98
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T7",
"type": "Condition",
"text": [
"AMD"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T8",
"type": "Condition",
"text": [
"BCVA"
],
"offsets": [
[
99,
103
]
],
"normalized": []
},
{
"id": "NCT02321839_inc_T9",
"type": "Qualifier",
"text": [
"24 letters or over"
],
"offsets": [
[
107,
125
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02321839_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02321839_inc_T4",
"arg2_id": "NCT02321839_inc_T5",
"normalized": []
},
{
"id": "NCT02321839_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02321839_inc_T8",
"arg2_id": "NCT02321839_inc_T9",
"normalized": []
}
] |
NCT02322203_exc | NCT02322203 | [
{
"id": "NCT02322203_exc_text",
"type": "exclusion",
"text": [
"Subjects taking any lipid modification therapy, including but not limited to statins, fibrates and bile acid sequestrants. \nSubjects taking fish oil or any other supplements, which in the investigator s opinion may interfere with the study. \nSubjects with acute liver disease or active peptic ulcer disease. \nSubjects with elevated uric acid levels greater than 10 mg/dL or gout \nPregnancy or women currently breastfeeding. \nFemale subjects taking hormonal contraceptives or hormone replacement therapy may be included in this study only if they have been on a stable dose for at least 3 months. \nBMI less than 18.5 \nSubjects with weight that varies greater than 20% over the past 3 months. \nSubjects taking the following medications for at least six weeks, which may interfere with the study, will be excluded: BAS, antibiotics, anticoagulants, anticonvulsants, antiarrhythmic, Cyclosporine, Mycophenolate and Synthroid. Subjects with chronic diarrhea, gastric bypass or lap band procedures, ostomies, bowel motility problems, or other conditions that could affect intestinal fat absorption. \nSubjects initiating new medications or patients on multiple medications may also be excluded. \nInability to swallow capsules \nPatients with a history of type I or type II diabetes or HbA1c greater than 6.5%. \nVolunteers may also be excluded, if in the opinion of the study investigators, they have some other condition or disorder that may adversely affect the outcome of the study or the safety of the volunteer. \n \n"
],
"offsets": [
[
0,
1520
]
]
}
] | [
{
"id": "NCT02322203_exc_T1",
"type": "Procedure",
"text": [
"lipid modification therapy"
],
"offsets": [
[
20,
46
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T2",
"type": "Drug",
"text": [
"statins"
],
"offsets": [
[
77,
84
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T3",
"type": "Drug",
"text": [
"fibrates"
],
"offsets": [
[
86,
94
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T4",
"type": "Drug",
"text": [
"bile acid sequestrants"
],
"offsets": [
[
99,
121
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T5",
"type": "Scope",
"text": [
"statins, fibrates and bile acid sequestrants"
],
"offsets": [
[
77,
121
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T7",
"type": "Drug",
"text": [
"fish oil"
],
"offsets": [
[
140,
148
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T10",
"type": "Condition",
"text": [
"acute liver disease"
],
"offsets": [
[
256,
275
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T11",
"type": "Condition",
"text": [
"peptic ulcer disease"
],
"offsets": [
[
286,
306
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T12",
"type": "Temporal",
"text": [
"active"
],
"offsets": [
[
279,
285
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T13",
"type": "Measurement",
"text": [
"uric acid levels"
],
"offsets": [
[
332,
348
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T14",
"type": "Value",
"text": [
"elevated"
],
"offsets": [
[
323,
331
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T15",
"type": "Value",
"text": [
"greater than 10 mg/dL"
],
"offsets": [
[
349,
370
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T16",
"type": "Condition",
"text": [
"gout"
],
"offsets": [
[
374,
378
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T17",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
380,
389
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T18",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
393,
398
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T19",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
409,
422
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T20",
"type": "Person",
"text": [
"Female"
],
"offsets": [
[
425,
431
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T21",
"type": "Drug",
"text": [
"hormonal contraceptives"
],
"offsets": [
[
448,
471
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T22",
"type": "Procedure",
"text": [
"hormone replacement therapy"
],
"offsets": [
[
475,
502
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T23",
"type": "Qualifier",
"text": [
"stable dose"
],
"offsets": [
[
561,
572
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T24",
"type": "Temporal",
"text": [
"for at least 3 months"
],
"offsets": [
[
573,
594
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T25",
"type": "Scope",
"text": [
"hormonal contraceptives or hormone replacement therapy"
],
"offsets": [
[
448,
502
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T27",
"type": "Measurement",
"text": [
"BMI"
],
"offsets": [
[
597,
600
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T28",
"type": "Value",
"text": [
"less than 18.5"
],
"offsets": [
[
601,
615
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T29",
"type": "Measurement",
"text": [
"weight"
],
"offsets": [
[
631,
637
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T30",
"type": "Qualifier",
"text": [
"varies greater than 20%"
],
"offsets": [
[
643,
666
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T31",
"type": "Temporal",
"text": [
"over the past 3 months"
],
"offsets": [
[
667,
689
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T32",
"type": "Temporal",
"text": [
"for at least six weeks"
],
"offsets": [
[
734,
756
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T33",
"type": "Drug",
"text": [
"BAS"
],
"offsets": [
[
812,
815
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T34",
"type": "Drug",
"text": [
"antibiotics"
],
"offsets": [
[
817,
828
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T35",
"type": "Drug",
"text": [
"anticoagulants"
],
"offsets": [
[
830,
844
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T36",
"type": "Drug",
"text": [
"anticonvulsants"
],
"offsets": [
[
846,
861
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T37",
"type": "Drug",
"text": [
"antiarrhythmic"
],
"offsets": [
[
863,
877
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T38",
"type": "Drug",
"text": [
"Cyclosporine"
],
"offsets": [
[
879,
891
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T39",
"type": "Drug",
"text": [
"Mycophenolate"
],
"offsets": [
[
893,
906
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T40",
"type": "Drug",
"text": [
"Synthroid"
],
"offsets": [
[
911,
920
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T42",
"type": "Scope",
"text": [
"BAS, antibiotics, anticoagulants, anticonvulsants, antiarrhythmic, Cyclosporine, Mycophenolate and Synthroid"
],
"offsets": [
[
812,
920
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T43",
"type": "Condition",
"text": [
"chronic diarrhea"
],
"offsets": [
[
936,
952
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T44",
"type": "Procedure",
"text": [
"gastric bypass"
],
"offsets": [
[
954,
968
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T45",
"type": "Procedure",
"text": [
"lap band procedures"
],
"offsets": [
[
972,
991
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T46",
"type": "Procedure",
"text": [
"ostomies"
],
"offsets": [
[
993,
1001
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T47",
"type": "Condition",
"text": [
"bowel motility problems"
],
"offsets": [
[
1003,
1026
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T48",
"type": "Condition",
"text": [
"conditions that could affect intestinal fat absorption"
],
"offsets": [
[
1037,
1091
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T51",
"type": "Condition",
"text": [
"Inability to swallow capsules"
],
"offsets": [
[
1189,
1218
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T52",
"type": "Condition",
"text": [
"type II diabetes"
],
"offsets": [
[
1257,
1273
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T53",
"type": "Condition",
"text": [
"type I",
"diabetes"
],
"offsets": [
[
1247,
1253
],
[
1265,
1273
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T54",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
1277,
1282
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T55",
"type": "Value",
"text": [
"greater than 6.5%"
],
"offsets": [
[
1283,
1300
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T56",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
1236,
1243
]
],
"normalized": []
},
{
"id": "NCT02322203_exc_T57",
"type": "Scope",
"text": [
"type I or type II diabetes or HbA1c greater than 6.5%"
],
"offsets": [
[
1247,
1300
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02322203_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02322203_exc_T1",
"arg2_id": "NCT02322203_exc_T5",
"normalized": []
},
{
"id": "NCT02322203_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02322203_exc_T11",
"arg2_id": "NCT02322203_exc_T12",
"normalized": []
},
{
"id": "NCT02322203_exc_R3",
"type": "AND",
"arg1_id": "NCT02322203_exc_T11",
"arg2_id": "NCT02322203_exc_T10",
"normalized": []
},
{
"id": "NCT02322203_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT02322203_exc_T14",
"arg2_id": "NCT02322203_exc_T15",
"normalized": []
},
{
"id": "NCT02322203_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02322203_exc_T13",
"arg2_id": "NCT02322203_exc_T14",
"normalized": []
},
{
"id": "NCT02322203_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02322203_exc_T23",
"arg2_id": "NCT02322203_exc_T24",
"normalized": []
},
{
"id": "NCT02322203_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02322203_exc_T25",
"arg2_id": "NCT02322203_exc_T23",
"normalized": []
},
{
"id": "NCT02322203_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02322203_exc_T27",
"arg2_id": "NCT02322203_exc_T28",
"normalized": []
},
{
"id": "NCT02322203_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02322203_exc_T30",
"arg2_id": "NCT02322203_exc_T31",
"normalized": []
},
{
"id": "NCT02322203_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02322203_exc_T29",
"arg2_id": "NCT02322203_exc_T30",
"normalized": []
},
{
"id": "NCT02322203_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02322203_exc_T42",
"arg2_id": "NCT02322203_exc_T32",
"normalized": []
},
{
"id": "NCT02322203_exc_R12",
"type": "Has_value",
"arg1_id": "NCT02322203_exc_T54",
"arg2_id": "NCT02322203_exc_T55",
"normalized": []
},
{
"id": "NCT02322203_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02322203_exc_T57",
"arg2_id": "NCT02322203_exc_T56",
"normalized": []
}
] |
NCT02322203_inc | NCT02322203 | [
{
"id": "NCT02322203_inc_text",
"type": "inclusion",
"text": [
"Males and females who are at least 18 years of age at time of enrollment. \nSubject understands the investigational nature of the study and provides written, informed consent. \n"
],
"offsets": [
[
0,
176
]
]
}
] | [
{
"id": "NCT02322203_inc_T1",
"type": "Person",
"text": [
"Males"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02322203_inc_T2",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
10,
17
]
],
"normalized": []
},
{
"id": "NCT02322203_inc_T3",
"type": "Value",
"text": [
"at least 18 years"
],
"offsets": [
[
26,
43
]
],
"normalized": []
},
{
"id": "NCT02322203_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
47,
50
]
],
"normalized": []
},
{
"id": "NCT02322203_inc_T5",
"type": "Temporal",
"text": [
"at time of enrollment"
],
"offsets": [
[
51,
72
]
],
"normalized": []
},
{
"id": "NCT02322203_inc_T6",
"type": "Reference_point",
"text": [
"time of enrollment"
],
"offsets": [
[
54,
72
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02322203_inc_R1",
"type": "Has_index",
"arg1_id": "NCT02322203_inc_T5",
"arg2_id": "NCT02322203_inc_T6",
"normalized": []
}
] |
NCT02323399_exc | NCT02323399 | [
{
"id": "NCT02323399_exc_text",
"type": "exclusion",
"text": [
"NA\n\n"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
NCT02323399_inc | NCT02323399 | [
{
"id": "NCT02323399_inc_text",
"type": "inclusion",
"text": [
"Subject's age is between =12 and 16 years, inclusive\nSubject is scheduled for a procedure that requires general or neuraxial anesthesia\nSubjects must have normal or clinically acceptable physical exam\nSubjects with controlled diabetes prior to entry must have a mean systolic/diastolic office blood pressure =128/78 mmHg (sitting, after 5 minutes of rest)\nFemales must have a urine or serum pregnancy test (Human Chorionic Gonadotropin) that is negative at Screening and Day 1\nSubject's parent or legal guardian gives informed consent and subject gives assent.\n"
],
"offsets": [
[
0,
561
]
]
}
] | [
{
"id": "NCT02323399_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T2",
"type": "Value",
"text": [
"between =12 and 16 years"
],
"offsets": [
[
17,
41
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T5",
"type": "Procedure",
"text": [
"procedure"
],
"offsets": [
[
80,
89
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T6",
"type": "Observation",
"text": [
"scheduled for a procedure"
],
"offsets": [
[
64,
89
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T7",
"type": "Procedure",
"text": [
"neuraxial anesthesia"
],
"offsets": [
[
115,
135
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T8",
"type": "Procedure",
"text": [
"eneral",
"h"
],
"offsets": [
[
105,
111
],
[
130,
131
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T9",
"type": "Scope",
"text": [
"general or neuraxial anesthesia"
],
"offsets": [
[
104,
135
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T10",
"type": "Procedure",
"text": [
"physical exam"
],
"offsets": [
[
187,
200
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T11",
"type": "Value",
"text": [
"clinically acceptable"
],
"offsets": [
[
165,
186
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T12",
"type": "Value",
"text": [
"normal"
],
"offsets": [
[
155,
161
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T13",
"type": "Scope",
"text": [
"normal or clinically acceptable"
],
"offsets": [
[
155,
186
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T14",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
226,
234
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T15",
"type": "Qualifier",
"text": [
"controlled"
],
"offsets": [
[
215,
225
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T16",
"type": "Temporal",
"text": [
"prior to entry"
],
"offsets": [
[
235,
249
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T17",
"type": "Reference_point",
"text": [
"entry"
],
"offsets": [
[
244,
249
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T18",
"type": "Condition",
"text": [
"n sy",
"stolic of",
"od pressure =1"
],
"offsets": [
[
265,
269
],
[
279,
288
],
[
296,
310
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T19",
"type": "Condition",
"text": [
"n sy",
"tolic/di",
"od pressure =1"
],
"offsets": [
[
265,
269
],
[
270,
278
],
[
296,
310
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T20",
"type": "Value",
"text": [
"78 mmHg"
],
"offsets": [
[
313,
320
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T21",
"type": "Value",
"text": [
"/78",
"g (s"
],
"offsets": [
[
312,
315
],
[
319,
323
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T22",
"type": "Qualifier",
"text": [
"sitting"
],
"offsets": [
[
322,
329
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T23",
"type": "Temporal",
"text": [
"after 5 minutes of rest"
],
"offsets": [
[
331,
354
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T24",
"type": "Reference_point",
"text": [
"rest"
],
"offsets": [
[
350,
354
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T25",
"type": "Scope",
"text": [
"mean systolic/diastolic office blood pressure =128/78 mmHg (sitting"
],
"offsets": [
[
262,
329
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T26",
"type": "Measurement",
"text": [
"serum pregnancy test"
],
"offsets": [
[
385,
405
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T27",
"type": "Measurement",
"text": [
"e or",
"nancy test (Hu"
],
"offsets": [
[
380,
384
],
[
395,
409
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T28",
"type": "Measurement",
"text": [
"Human Chorionic Gonadotropin"
],
"offsets": [
[
407,
435
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T29",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
445,
453
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T30",
"type": "Temporal",
"text": [
"at Screening"
],
"offsets": [
[
454,
466
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T31",
"type": "Temporal",
"text": [
"Day 1"
],
"offsets": [
[
471,
476
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T32",
"type": "Scope",
"text": [
"urine or serum pregnancy test (Human Chorionic Gonadotropin)"
],
"offsets": [
[
376,
436
]
],
"normalized": []
},
{
"id": "NCT02323399_inc_T33",
"type": "Scope",
"text": [
"at Screening and Day 1"
],
"offsets": [
[
454,
476
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02323399_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02323399_inc_T1",
"arg2_id": "NCT02323399_inc_T2",
"normalized": []
},
{
"id": "NCT02323399_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02323399_inc_T5",
"arg2_id": "NCT02323399_inc_T9",
"normalized": []
},
{
"id": "NCT02323399_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02323399_inc_T10",
"arg2_id": "NCT02323399_inc_T13",
"normalized": []
},
{
"id": "NCT02323399_inc_R5",
"type": "Has_index",
"arg1_id": "NCT02323399_inc_T16",
"arg2_id": "NCT02323399_inc_T17",
"normalized": []
},
{
"id": "NCT02323399_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02323399_inc_T18",
"arg2_id": "NCT02323399_inc_T20",
"normalized": []
},
{
"id": "NCT02323399_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02323399_inc_T19",
"arg2_id": "NCT02323399_inc_T21",
"normalized": []
},
{
"id": "NCT02323399_inc_R8",
"type": "Has_index",
"arg1_id": "NCT02323399_inc_T23",
"arg2_id": "NCT02323399_inc_T24",
"normalized": []
},
{
"id": "NCT02323399_inc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02323399_inc_T25",
"arg2_id": "NCT02323399_inc_T22",
"normalized": []
},
{
"id": "NCT02323399_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02323399_inc_T25",
"arg2_id": "NCT02323399_inc_T23",
"normalized": []
},
{
"id": "NCT02323399_inc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02323399_inc_T14",
"arg2_id": "NCT02323399_inc_T15",
"normalized": []
},
{
"id": "NCT02323399_inc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02323399_inc_T14",
"arg2_id": "NCT02323399_inc_T16",
"normalized": []
},
{
"id": "NCT02323399_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02323399_inc_T32",
"arg2_id": "NCT02323399_inc_T29",
"normalized": []
},
{
"id": "NCT02323399_inc_R14",
"type": "Has_scope",
"arg1_id": "NCT02323399_inc_T32",
"arg2_id": "NCT02323399_inc_T33",
"normalized": []
}
] |
NCT02330705_exc | NCT02330705 | [
{
"id": "NCT02330705_exc_text",
"type": "exclusion",
"text": [
"Advanced male factor infertility.\nPolycystic ovary syndrome (PCOS) as defined by the Rotterdam criteria.\nEndometriosis.\nTubal disease.\nUterine abnormalities or myoma.\nPrevious uterine surgery.\nMetabolic or hormonal abnormalities.\n"
],
"offsets": [
[
0,
230
]
]
}
] | [
{
"id": "NCT02330705_exc_T1",
"type": "Qualifier",
"text": [
"Advanced"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T2",
"type": "Condition",
"text": [
"male factor infertility"
],
"offsets": [
[
9,
32
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T3",
"type": "Condition",
"text": [
"Polycystic ovary syndrome (PCOS)"
],
"offsets": [
[
34,
66
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T4",
"type": "Qualifier",
"text": [
"Rotterdam criteria"
],
"offsets": [
[
85,
103
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T5",
"type": "Condition",
"text": [
"Endometriosis"
],
"offsets": [
[
105,
118
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T6",
"type": "Condition",
"text": [
"Tubal disease"
],
"offsets": [
[
120,
133
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T7",
"type": "Condition",
"text": [
"Uterine abnormalities"
],
"offsets": [
[
135,
156
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T8",
"type": "Condition",
"text": [
"myoma"
],
"offsets": [
[
160,
165
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T9",
"type": "Procedure",
"text": [
"uterine surgery"
],
"offsets": [
[
176,
191
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T10",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
167,
175
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T11",
"type": "Condition",
"text": [
"lic or ho",
"alities."
],
"offsets": [
[
199,
208
],
[
221,
229
]
],
"normalized": []
},
{
"id": "NCT02330705_exc_T12",
"type": "Condition",
"text": [
"hormonal abnormalities"
],
"offsets": [
[
206,
228
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02330705_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02330705_exc_T2",
"arg2_id": "NCT02330705_exc_T1",
"normalized": []
},
{
"id": "NCT02330705_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02330705_exc_T3",
"arg2_id": "NCT02330705_exc_T4",
"normalized": []
},
{
"id": "NCT02330705_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02330705_exc_T9",
"arg2_id": "NCT02330705_exc_T10",
"normalized": []
}
] |
NCT02330705_inc | NCT02330705 | [
{
"id": "NCT02330705_inc_text",
"type": "inclusion",
"text": [
"Mild male factor infertility or unexplained infertility.\n"
],
"offsets": [
[
0,
57
]
]
}
] | [
{
"id": "NCT02330705_inc_T1",
"type": "Qualifier",
"text": [
"Mild"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02330705_inc_T2",
"type": "Condition",
"text": [
"male factor infertility"
],
"offsets": [
[
5,
28
]
],
"normalized": []
},
{
"id": "NCT02330705_inc_T3",
"type": "Condition",
"text": [
"unexplained infertility"
],
"offsets": [
[
32,
55
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02330705_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02330705_inc_T2",
"arg2_id": "NCT02330705_inc_T1",
"normalized": []
}
] |
NCT02330757_exc | NCT02330757 | [
{
"id": "NCT02330757_exc_text",
"type": "exclusion",
"text": [
"PCOS or polycystic ovary on ultrasound scan.\nModerate or severe endometriosis.\nHydrosalpinx.\nUterine abnormalities or myoma.\nPrevious uterine surgery.\n"
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "NCT02330757_exc_T1",
"type": "Condition",
"text": [
"PCOS"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T2",
"type": "Condition",
"text": [
"polycystic ovary"
],
"offsets": [
[
8,
24
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T3",
"type": "Procedure",
"text": [
"ultrasound scan"
],
"offsets": [
[
28,
43
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T4",
"type": "Scope",
"text": [
"PCOS or polycystic ovary"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T5",
"type": "Qualifier",
"text": [
"Moderate"
],
"offsets": [
[
45,
53
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T6",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
57,
63
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T7",
"type": "Condition",
"text": [
"endometriosis"
],
"offsets": [
[
64,
77
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T8",
"type": "Scope",
"text": [
"Moderate or severe"
],
"offsets": [
[
45,
63
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T9",
"type": "Condition",
"text": [
"Hydrosalpinx"
],
"offsets": [
[
79,
91
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T10",
"type": "Condition",
"text": [
"Uterine abnormalities"
],
"offsets": [
[
93,
114
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T11",
"type": "Condition",
"text": [
"myoma"
],
"offsets": [
[
118,
123
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T12",
"type": "Procedure",
"text": [
"uterine surgery"
],
"offsets": [
[
134,
149
]
],
"normalized": []
},
{
"id": "NCT02330757_exc_T13",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
125,
133
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02330757_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02330757_exc_T3",
"arg2_id": "NCT02330757_exc_T4",
"normalized": []
},
{
"id": "NCT02330757_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT02330757_exc_T7",
"arg2_id": "NCT02330757_exc_T8",
"normalized": []
},
{
"id": "NCT02330757_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02330757_exc_T12",
"arg2_id": "NCT02330757_exc_T13",
"normalized": []
}
] |
NCT02330757_inc | NCT02330757 | [
{
"id": "NCT02330757_inc_text",
"type": "inclusion",
"text": [
"Women without PCOS as defined by the Rotterdam criteria.\nPresence of at least 2 cryopreserved good quality cleavage-stage embryo (good quality cleavage-stage embryos display stage-specific cell division, have blastomeres of fairly equal size with few to no cytoplasmic fragments).\n"
],
"offsets": [
[
0,
281
]
]
}
] | [
{
"id": "NCT02330757_inc_T1",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
6,
13
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T2",
"type": "Condition",
"text": [
"PCOS"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T3",
"type": "Qualifier",
"text": [
"Rotterdam criteria"
],
"offsets": [
[
37,
55
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T4",
"type": "Multiplier",
"text": [
"at least 2"
],
"offsets": [
[
69,
79
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T5",
"type": "Qualifier",
"text": [
"cryopreserved"
],
"offsets": [
[
80,
93
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T6",
"type": "Qualifier",
"text": [
"good quality"
],
"offsets": [
[
94,
106
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T7",
"type": "Observation",
"text": [
"cleavage-stage embryo"
],
"offsets": [
[
107,
128
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T8",
"type": "Qualifier",
"text": [
"good quality"
],
"offsets": [
[
130,
142
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T9",
"type": "Observation",
"text": [
"cleavage-stage embryos"
],
"offsets": [
[
143,
165
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T10",
"type": "Qualifier",
"text": [
"stage-specific cell division"
],
"offsets": [
[
174,
202
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T11",
"type": "Qualifier",
"text": [
"have blastomeres of fairly equal size"
],
"offsets": [
[
204,
241
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T12",
"type": "Qualifier",
"text": [
"few to no cytoplasmic fragments"
],
"offsets": [
[
247,
278
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T13",
"type": "Scope",
"text": [
"stage-specific cell division, have blastomeres of fairly equal size with few to no cytoplasmic fragments"
],
"offsets": [
[
174,
278
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T14",
"type": "Scope",
"text": [
"good quality cleavage-stage embryos display stage-specific cell division, have blastomeres of fairly equal size with few to no cytoplasmic fragments"
],
"offsets": [
[
130,
278
]
],
"normalized": []
},
{
"id": "NCT02330757_inc_T15",
"type": "Scope",
"text": [
"good quality cleavage-stage embryo"
],
"offsets": [
[
94,
128
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02330757_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02330757_inc_T2",
"arg2_id": "NCT02330757_inc_T3",
"normalized": []
},
{
"id": "NCT02330757_inc_R2",
"type": "Has_negation",
"arg1_id": "NCT02330757_inc_T2",
"arg2_id": "NCT02330757_inc_T1",
"normalized": []
},
{
"id": "NCT02330757_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02330757_inc_T7",
"arg2_id": "NCT02330757_inc_T6",
"normalized": []
},
{
"id": "NCT02330757_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02330757_inc_T7",
"arg2_id": "NCT02330757_inc_T5",
"normalized": []
},
{
"id": "NCT02330757_inc_R5",
"type": "Has_multiplier",
"arg1_id": "NCT02330757_inc_T7",
"arg2_id": "NCT02330757_inc_T4",
"normalized": []
},
{
"id": "NCT02330757_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02330757_inc_T9",
"arg2_id": "NCT02330757_inc_T8",
"normalized": []
},
{
"id": "NCT02330757_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02330757_inc_T9",
"arg2_id": "NCT02330757_inc_T13",
"normalized": []
},
{
"id": "NCT02330757_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02330757_inc_T15",
"arg2_id": "NCT02330757_inc_T14",
"normalized": []
}
] |
NCT02332291_exc | NCT02332291 | [
{
"id": "NCT02332291_exc_text",
"type": "exclusion",
"text": [
"Current or past diagnoses of other Axis I psychiatric disorders, except for generalized anxiety disorder (GAD) symptoms occurring during a depressive episode\nHistory of alcohol or drug dependence or abuse in the last three years\nHistory of developmental disorder or IQ score < 70\nPresence of acute suicidality\nAcute grief (< 1 month)\nCurrent or past psychosis\nPrimary neurological disorder, including but not limited to dementia, stroke, brain tumors, epilepsy, Parkinson's disease, or demyelinating diseases\nMRI contraindications\nAny physical or intellectual disability adversely affecting ability to complete assessments\nElectroconvulsive therapy in last 6 months\nUse of antidepressant medications or other psychotropic medications in the last 4 weeks (or the last 6 weeks for fluoxetine). Occasional use of benzodiazepines or non-benzodiazepine sedatives (such as zolpidem, eszopiclone, or zaleplon) during this period is allowable.\nA failed therapeutic trial of escitalopram in the current depressive episode (defined as at least 6 weeks of treatment at a daily dose of 10mg or higher)\nKnown allergy or hypersensitivity to escitalopram or bupropion\nCurrent or planned psychotherapy\n"
],
"offsets": [
[
0,
1186
]
]
}
] | [
{
"id": "NCT02332291_exc_T1",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
29,
34
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T2",
"type": "Condition",
"text": [
"Axis I psychiatric disorders"
],
"offsets": [
[
35,
63
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T3",
"type": "Negation",
"text": [
"except for"
],
"offsets": [
[
65,
75
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T4",
"type": "Condition",
"text": [
"generalized anxiety disorder (GAD)"
],
"offsets": [
[
76,
110
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T5",
"type": "Temporal",
"text": [
"during a depressive episode"
],
"offsets": [
[
130,
157
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T6",
"type": "Reference_point",
"text": [
"depressive episode"
],
"offsets": [
[
139,
157
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T7",
"type": "Condition",
"text": [
"depressive episode"
],
"offsets": [
[
139,
157
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T8",
"type": "Condition",
"text": [
"drug dependence"
],
"offsets": [
[
180,
195
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T9",
"type": "Condition",
"text": [
"lcohol",
"ependence"
],
"offsets": [
[
170,
176
],
[
186,
195
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T10",
"type": "Condition",
"text": [
"rug",
"buse"
],
"offsets": [
[
181,
184
],
[
200,
204
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T11",
"type": "Condition",
"text": [
"lcohol",
"buse"
],
"offsets": [
[
170,
176
],
[
200,
204
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T12",
"type": "Temporal",
"text": [
"in the last three years"
],
"offsets": [
[
205,
228
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T13",
"type": "Scope",
"text": [
"alcohol or drug dependence or abuse"
],
"offsets": [
[
169,
204
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T14",
"type": "Condition",
"text": [
"developmental disorder"
],
"offsets": [
[
240,
262
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T15",
"type": "Measurement",
"text": [
"IQ score"
],
"offsets": [
[
266,
274
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T16",
"type": "Value",
"text": [
"< 70"
],
"offsets": [
[
275,
279
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T17",
"type": "Condition",
"text": [
"acute suicidality"
],
"offsets": [
[
292,
309
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T18",
"type": "Condition",
"text": [
"Acute grief"
],
"offsets": [
[
310,
321
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T19",
"type": "Temporal",
"text": [
"< 1 month"
],
"offsets": [
[
323,
332
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T20",
"type": "Condition",
"text": [
"psychosis"
],
"offsets": [
[
350,
359
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T21",
"type": "Temporal",
"text": [
"past"
],
"offsets": [
[
345,
349
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T22",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
334,
341
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T23",
"type": "Scope",
"text": [
"Current or past"
],
"offsets": [
[
334,
349
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T24",
"type": "Condition",
"text": [
"Primary neurological disorder"
],
"offsets": [
[
360,
389
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T25",
"type": "Condition",
"text": [
"dementia"
],
"offsets": [
[
420,
428
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T26",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
430,
436
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T27",
"type": "Condition",
"text": [
"brain tumors"
],
"offsets": [
[
438,
450
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T28",
"type": "Condition",
"text": [
"epilepsy"
],
"offsets": [
[
452,
460
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T29",
"type": "Condition",
"text": [
"Parkinson's disease"
],
"offsets": [
[
462,
481
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T30",
"type": "Condition",
"text": [
"demyelinating diseases"
],
"offsets": [
[
486,
508
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T31",
"type": "Scope",
"text": [
"dementia, stroke, brain tumors, epilepsy, Parkinson's disease, or demyelinating diseases"
],
"offsets": [
[
420,
508
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T32",
"type": "Procedure",
"text": [
"MRI"
],
"offsets": [
[
509,
512
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T33",
"type": "Condition",
"text": [
"contraindications"
],
"offsets": [
[
513,
530
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T34",
"type": "Condition",
"text": [
"intellectual disability"
],
"offsets": [
[
547,
570
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T35",
"type": "Condition",
"text": [
" or int",
"ty adverse"
],
"offsets": [
[
543,
550
],
[
568,
578
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T36",
"type": "Procedure",
"text": [
"Electroconvulsive therapy"
],
"offsets": [
[
623,
648
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T37",
"type": "Temporal",
"text": [
"in last 6 months"
],
"offsets": [
[
649,
665
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T38",
"type": "Drug",
"text": [
"antidepressant medications"
],
"offsets": [
[
673,
699
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T39",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
703,
708
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T40",
"type": "Drug",
"text": [
"psychotropic medications"
],
"offsets": [
[
709,
733
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T41",
"type": "Temporal",
"text": [
"in the last 4 weeks"
],
"offsets": [
[
734,
753
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T42",
"type": "Temporal",
"text": [
"t",
" weeks for fluo"
],
"offsets": [
[
744,
745
],
[
768,
783
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T43",
"type": "Drug",
"text": [
"fluoxetine"
],
"offsets": [
[
779,
789
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T44",
"type": "Scope",
"text": [
"in the last 4 weeks (or the last 6 weeks for fluoxetine)"
],
"offsets": [
[
734,
790
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T45",
"type": "Scope",
"text": [
"antidepressant medications or other psychotropic medications"
],
"offsets": [
[
673,
733
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T46",
"type": "Multiplier",
"text": [
"Occasional use"
],
"offsets": [
[
792,
806
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T47",
"type": "Drug",
"text": [
"pines or non-be",
"(such as"
],
"offsets": [
[
820,
835
],
[
858,
866
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T48",
"type": "Drug",
"text": [
"non-benzodiazepine sedatives"
],
"offsets": [
[
829,
857
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T49",
"type": "Drug",
"text": [
"zolpidem"
],
"offsets": [
[
867,
875
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T50",
"type": "Drug",
"text": [
"eszopiclone"
],
"offsets": [
[
877,
888
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T51",
"type": "Drug",
"text": [
"zaleplon"
],
"offsets": [
[
893,
901
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T52",
"type": "Scope",
"text": [
"zolpidem, eszopiclone, or zaleplon"
],
"offsets": [
[
867,
901
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T53",
"type": "Negation",
"text": [
"is allowable"
],
"offsets": [
[
922,
934
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T54",
"type": "Scope",
"text": [
"benzodiazepines or non-benzodiazepine sedatives"
],
"offsets": [
[
810,
857
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T55",
"type": "Drug",
"text": [
"escitalopram"
],
"offsets": [
[
966,
978
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T56",
"type": "Procedure",
"text": [
"therapeutic trial"
],
"offsets": [
[
945,
962
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T57",
"type": "Qualifier",
"text": [
"failed"
],
"offsets": [
[
938,
944
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T58",
"type": "Temporal",
"text": [
"in the current depressive episode"
],
"offsets": [
[
979,
1012
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T59",
"type": "Reference_point",
"text": [
"depressive episode"
],
"offsets": [
[
994,
1012
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T60",
"type": "Condition",
"text": [
"depressive episode"
],
"offsets": [
[
994,
1012
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T61",
"type": "Temporal",
"text": [
"at least 6 weeks of treatment"
],
"offsets": [
[
1025,
1054
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T62",
"type": "Multiplier",
"text": [
"daily dose of 10mg or higher"
],
"offsets": [
[
1060,
1088
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T63",
"type": "Scope",
"text": [
"at least 6 weeks of treatment at a daily dose of 10mg or higher"
],
"offsets": [
[
1025,
1088
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T64",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
1096,
1103
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T65",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
1107,
1123
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T66",
"type": "Drug",
"text": [
"escitalopram"
],
"offsets": [
[
1127,
1139
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T67",
"type": "Drug",
"text": [
"bupropion"
],
"offsets": [
[
1143,
1152
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T68",
"type": "Scope",
"text": [
"allergy or hypersensitivity"
],
"offsets": [
[
1096,
1123
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T69",
"type": "Scope",
"text": [
"escitalopram or bupropion"
],
"offsets": [
[
1127,
1152
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T70",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
1164,
1171
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T71",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
1153,
1160
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T72",
"type": "Procedure",
"text": [
"psychotherapy"
],
"offsets": [
[
1172,
1185
]
],
"normalized": []
},
{
"id": "NCT02332291_exc_T73",
"type": "Scope",
"text": [
"Current or planned"
],
"offsets": [
[
1153,
1171
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02332291_exc_R1",
"type": "Has_index",
"arg1_id": "NCT02332291_exc_T5",
"arg2_id": "NCT02332291_exc_T6",
"normalized": []
},
{
"id": "NCT02332291_exc_R2",
"type": "AND",
"arg1_id": "NCT02332291_exc_T6",
"arg2_id": "NCT02332291_exc_T7",
"normalized": []
},
{
"id": "NCT02332291_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02332291_exc_T4",
"arg2_id": "NCT02332291_exc_T3",
"normalized": []
},
{
"id": "NCT02332291_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02332291_exc_T4",
"arg2_id": "NCT02332291_exc_T5",
"normalized": []
},
{
"id": "NCT02332291_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02332291_exc_T2",
"arg2_id": "NCT02332291_exc_T1",
"normalized": []
},
{
"id": "NCT02332291_exc_R6",
"type": "AND",
"arg1_id": "NCT02332291_exc_T2",
"arg2_id": "NCT02332291_exc_T4",
"normalized": []
},
{
"id": "NCT02332291_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02332291_exc_T13",
"arg2_id": "NCT02332291_exc_T12",
"normalized": []
},
{
"id": "NCT02332291_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02332291_exc_T15",
"arg2_id": "NCT02332291_exc_T16",
"normalized": []
},
{
"id": "NCT02332291_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02332291_exc_T18",
"arg2_id": "NCT02332291_exc_T19",
"normalized": []
},
{
"id": "NCT02332291_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02332291_exc_T20",
"arg2_id": "NCT02332291_exc_T23",
"normalized": []
},
{
"id": "NCT02332291_exc_R11",
"type": "Subsumes",
"arg1_id": "NCT02332291_exc_T24",
"arg2_id": "NCT02332291_exc_T31",
"normalized": []
},
{
"id": "NCT02332291_exc_R12",
"type": "AND",
"arg1_id": "NCT02332291_exc_T33",
"arg2_id": "NCT02332291_exc_T32",
"normalized": []
},
{
"id": "NCT02332291_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02332291_exc_T36",
"arg2_id": "NCT02332291_exc_T37",
"normalized": []
},
{
"id": "NCT02332291_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02332291_exc_T40",
"arg2_id": "NCT02332291_exc_T39",
"normalized": []
},
{
"id": "NCT02332291_exc_R15",
"type": "AND",
"arg1_id": "NCT02332291_exc_T42",
"arg2_id": "NCT02332291_exc_T43",
"normalized": []
},
{
"id": "NCT02332291_exc_R16",
"type": "Has_scope",
"arg1_id": "NCT02332291_exc_T45",
"arg2_id": "NCT02332291_exc_T44",
"normalized": []
},
{
"id": "NCT02332291_exc_R17",
"type": "Subsumes",
"arg1_id": "NCT02332291_exc_T54",
"arg2_id": "NCT02332291_exc_T52",
"normalized": []
},
{
"id": "NCT02332291_exc_R18",
"type": "Has_negation",
"arg1_id": "NCT02332291_exc_T54",
"arg2_id": "NCT02332291_exc_T53",
"normalized": []
},
{
"id": "NCT02332291_exc_R19",
"type": "Has_multiplier",
"arg1_id": "NCT02332291_exc_T54",
"arg2_id": "NCT02332291_exc_T46",
"normalized": []
},
{
"id": "NCT02332291_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT02332291_exc_T56",
"arg2_id": "NCT02332291_exc_T57",
"normalized": []
},
{
"id": "NCT02332291_exc_R21",
"type": "AND",
"arg1_id": "NCT02332291_exc_T56",
"arg2_id": "NCT02332291_exc_T55",
"normalized": []
},
{
"id": "NCT02332291_exc_R23",
"type": "AND",
"arg1_id": "NCT02332291_exc_T58",
"arg2_id": "NCT02332291_exc_T60",
"normalized": []
},
{
"id": "NCT02332291_exc_R24",
"type": "Subsumes",
"arg1_id": "NCT02332291_exc_T58",
"arg2_id": "NCT02332291_exc_T63",
"normalized": []
},
{
"id": "NCT02332291_exc_R25",
"type": "Has_temporal",
"arg1_id": "NCT02332291_exc_T55",
"arg2_id": "NCT02332291_exc_T58",
"normalized": []
},
{
"id": "NCT02332291_exc_R26",
"type": "Subsumes",
"arg1_id": "NCT02332291_exc_T68",
"arg2_id": "NCT02332291_exc_T69",
"normalized": []
},
{
"id": "NCT02332291_exc_R27",
"type": "Has_scope",
"arg1_id": "NCT02332291_exc_T72",
"arg2_id": "NCT02332291_exc_T73",
"normalized": []
}
] |
NCT02332291_inc | NCT02332291 | [
{
"id": "NCT02332291_inc_text",
"type": "inclusion",
"text": [
"Age 60 years or older.\nCurrent diagnosis of major depressive disorder (DSM-IV-TR), single episode, recurrent or chronic, without psychotic features, as detected by MINI and clinical exam.\nMinimum MADRS score = 15.\nMini-Mental State Exam = 24.\nFluent in English.\n"
],
"offsets": [
[
0,
262
]
]
}
] | [
{
"id": "NCT02332291_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T2",
"type": "Value",
"text": [
"60 years or older"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T3",
"type": "Condition",
"text": [
"major depressive disorder"
],
"offsets": [
[
44,
69
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T4",
"type": "Procedure",
"text": [
"DSM-IV-TR"
],
"offsets": [
[
71,
80
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T5",
"type": "Multiplier",
"text": [
"single episode"
],
"offsets": [
[
83,
97
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T6",
"type": "Multiplier",
"text": [
"recurrent"
],
"offsets": [
[
99,
108
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T7",
"type": "Multiplier",
"text": [
"chronic"
],
"offsets": [
[
112,
119
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T8",
"type": "Scope",
"text": [
"single episode, recurrent or chronic"
],
"offsets": [
[
83,
119
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T9",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
121,
128
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T10",
"type": "Condition",
"text": [
"psychotic features"
],
"offsets": [
[
129,
147
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T11",
"type": "Procedure",
"text": [
"MINI"
],
"offsets": [
[
164,
168
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T12",
"type": "Procedure",
"text": [
"clinical exam"
],
"offsets": [
[
173,
186
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T13",
"type": "Scope",
"text": [
"MINI and clinical exam"
],
"offsets": [
[
164,
186
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T14",
"type": "Measurement",
"text": [
"MADRS score"
],
"offsets": [
[
196,
207
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T15",
"type": "Value",
"text": [
"nimum M",
"15."
],
"offsets": [
[
190,
197
],
[
210,
213
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T16",
"type": "Measurement",
"text": [
"Mini-Mental State Exam"
],
"offsets": [
[
214,
236
]
],
"normalized": []
},
{
"id": "NCT02332291_inc_T17",
"type": "Value",
"text": [
"= 24"
],
"offsets": [
[
237,
241
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02332291_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02332291_inc_T1",
"arg2_id": "NCT02332291_inc_T2",
"normalized": []
},
{
"id": "NCT02332291_inc_R2",
"type": "AND",
"arg1_id": "NCT02332291_inc_T3",
"arg2_id": "NCT02332291_inc_T4",
"normalized": []
},
{
"id": "NCT02332291_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT02332291_inc_T10",
"arg2_id": "NCT02332291_inc_T9",
"normalized": []
},
{
"id": "NCT02332291_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02332291_inc_T3",
"arg2_id": "NCT02332291_inc_T8",
"normalized": []
},
{
"id": "NCT02332291_inc_R5",
"type": "AND",
"arg1_id": "NCT02332291_inc_T3",
"arg2_id": "NCT02332291_inc_T10",
"normalized": []
},
{
"id": "NCT02332291_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02332291_inc_T3",
"arg2_id": "NCT02332291_inc_T13",
"normalized": []
},
{
"id": "NCT02332291_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02332291_inc_T14",
"arg2_id": "NCT02332291_inc_T15",
"normalized": []
},
{
"id": "NCT02332291_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02332291_inc_T16",
"arg2_id": "NCT02332291_inc_T17",
"normalized": []
}
] |
NCT02334631_exc | NCT02334631 | [
{
"id": "NCT02334631_exc_text",
"type": "exclusion",
"text": [
"Patients with a contraindication to VCE (small bowel strictures, oropharyngeal dysphagia, pregnancy, patients who are not surgical candidates)\nEndoscopic insertion of video capsule endoscope\nInpatient procedures for active GI bleeding\nPatients with fluid restriction or who are unable to drink up to 900 ml of fluid within 10 minutes prior to the VCE\n"
],
"offsets": [
[
0,
351
]
]
}
] | [
{
"id": "NCT02334631_exc_T1",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
16,
32
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T2",
"type": "Procedure",
"text": [
"VCE"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T3",
"type": "Condition",
"text": [
"small bowel strictures"
],
"offsets": [
[
41,
63
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T4",
"type": "Condition",
"text": [
"oropharyngeal dysphagia"
],
"offsets": [
[
65,
88
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T5",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
90,
99
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T6",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
118,
121
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T7",
"type": "Observation",
"text": [
"surgical candidates"
],
"offsets": [
[
122,
141
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T8",
"type": "Scope",
"text": [
"small bowel strictures, oropharyngeal dysphagia, pregnancy, patients who are not surgical candidates"
],
"offsets": [
[
41,
141
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T9",
"type": "Procedure",
"text": [
"Endoscopic insertion"
],
"offsets": [
[
143,
163
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T10",
"type": "Device",
"text": [
"video capsule endoscope"
],
"offsets": [
[
167,
190
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T11",
"type": "Procedure",
"text": [
"Inpatient procedures"
],
"offsets": [
[
191,
211
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T12",
"type": "Condition",
"text": [
"GI bleeding"
],
"offsets": [
[
223,
234
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T13",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
216,
222
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T14",
"type": "Observation",
"text": [
"fluid restriction"
],
"offsets": [
[
249,
266
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T15",
"type": "Observation",
"text": [
"unable to drink"
],
"offsets": [
[
278,
293
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T16",
"type": "Temporal",
"text": [
"prior to the VCE"
],
"offsets": [
[
334,
350
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T17",
"type": "Procedure",
"text": [
"VCE"
],
"offsets": [
[
347,
350
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T18",
"type": "Reference_point",
"text": [
"the VCE"
],
"offsets": [
[
343,
350
]
],
"normalized": []
},
{
"id": "NCT02334631_exc_T19",
"type": "Scope",
"text": [
"fluid restriction or who are unable to drink"
],
"offsets": [
[
249,
293
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02334631_exc_R1",
"type": "AND",
"arg1_id": "NCT02334631_exc_T1",
"arg2_id": "NCT02334631_exc_T2",
"normalized": []
},
{
"id": "NCT02334631_exc_R2",
"type": "Has_negation",
"arg1_id": "NCT02334631_exc_T7",
"arg2_id": "NCT02334631_exc_T6",
"normalized": []
},
{
"id": "NCT02334631_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02334631_exc_T1",
"arg2_id": "NCT02334631_exc_T8",
"normalized": []
},
{
"id": "NCT02334631_exc_R4",
"type": "AND",
"arg1_id": "NCT02334631_exc_T9",
"arg2_id": "NCT02334631_exc_T10",
"normalized": []
},
{
"id": "NCT02334631_exc_R5",
"type": "AND",
"arg1_id": "NCT02334631_exc_T11",
"arg2_id": "NCT02334631_exc_T12",
"normalized": []
},
{
"id": "NCT02334631_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02334631_exc_T12",
"arg2_id": "NCT02334631_exc_T13",
"normalized": []
},
{
"id": "NCT02334631_exc_R8",
"type": "Has_index",
"arg1_id": "NCT02334631_exc_T16",
"arg2_id": "NCT02334631_exc_T18",
"normalized": []
},
{
"id": "NCT02334631_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02334631_exc_T19",
"arg2_id": "NCT02334631_exc_T16",
"normalized": []
}
] |
NCT02334631_inc | NCT02334631 | [
{
"id": "NCT02334631_inc_text",
"type": "inclusion",
"text": [
"Patients undergoing small bowel video capsule endoscopy\n"
],
"offsets": [
[
0,
56
]
]
}
] | [
{
"id": "NCT02334631_inc_T1",
"type": "Procedure",
"text": [
"small bowel video capsule endoscopy"
],
"offsets": [
[
20,
55
]
],
"normalized": []
}
] | [] | [] | [] |
NCT02334722_exc | NCT02334722 | [
{
"id": "NCT02334722_exc_text",
"type": "exclusion",
"text": [
"No known history of seizure activity.\nPregnant or breastfeeding.\nRenal dysfunction (CrCl < 30ml/min).\nBeck's Depression Inventory (BDI) =14\nAllergy to levetiracetam.\n"
],
"offsets": [
[
0,
166
]
]
}
] | [
{
"id": "NCT02334722_exc_T1",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
0,
2
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T2",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
9,
16
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T3",
"type": "Condition",
"text": [
"seizure activity"
],
"offsets": [
[
20,
36
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T4",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
38,
46
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T5",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
50,
63
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T6",
"type": "Condition",
"text": [
"Renal dysfunction"
],
"offsets": [
[
65,
82
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T7",
"type": "Measurement",
"text": [
"CrCl"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T8",
"type": "Value",
"text": [
"< 30ml/min"
],
"offsets": [
[
89,
99
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T9",
"type": "Scope",
"text": [
"CrCl < 30ml/min"
],
"offsets": [
[
84,
99
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T10",
"type": "Measurement",
"text": [
"Beck's Depression Inventory (BDI)"
],
"offsets": [
[
102,
135
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T11",
"type": "Value",
"text": [
"=14"
],
"offsets": [
[
136,
139
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T12",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
140,
147
]
],
"normalized": []
},
{
"id": "NCT02334722_exc_T13",
"type": "Drug",
"text": [
"levetiracetam"
],
"offsets": [
[
151,
164
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02334722_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT02334722_exc_T2",
"arg2_id": "NCT02334722_exc_T1",
"normalized": []
},
{
"id": "NCT02334722_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02334722_exc_T3",
"arg2_id": "NCT02334722_exc_T2",
"normalized": []
},
{
"id": "NCT02334722_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02334722_exc_T7",
"arg2_id": "NCT02334722_exc_T8",
"normalized": []
},
{
"id": "NCT02334722_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT02334722_exc_T6",
"arg2_id": "NCT02334722_exc_T9",
"normalized": []
},
{
"id": "NCT02334722_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02334722_exc_T10",
"arg2_id": "NCT02334722_exc_T11",
"normalized": []
},
{
"id": "NCT02334722_exc_R6",
"type": "AND",
"arg1_id": "NCT02334722_exc_T12",
"arg2_id": "NCT02334722_exc_T13",
"normalized": []
}
] |
NCT02334722_inc | NCT02334722 | [
{
"id": "NCT02334722_inc_text",
"type": "inclusion",
"text": [
"Adult (>18 years of age and older) patients who have or will have undergone surgical resection or biopsy of a supratentorial brain tumor and are able to consent for themselves.\nAble to be randomized prior to or up to 48 hours after surgery.\n"
],
"offsets": [
[
0,
241
]
]
}
] | [
{
"id": "NCT02334722_inc_T1",
"type": "Person",
"text": [
"Adult"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T2",
"type": "Value",
"text": [
"and older",
">18 years"
],
"offsets": [
[
24,
33
],
[
7,
16
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T4",
"type": "Scope",
"text": [
">18 years of age and older"
],
"offsets": [
[
7,
33
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T5",
"type": "Mood",
"text": [
"will have undergone"
],
"offsets": [
[
56,
75
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T6",
"type": "Procedure",
"text": [
"surgical resection"
],
"offsets": [
[
76,
94
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T7",
"type": "Procedure",
"text": [
"biopsy"
],
"offsets": [
[
98,
104
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T8",
"type": "Condition",
"text": [
"supratentorial brain tumor"
],
"offsets": [
[
110,
136
]
],
"normalized": []
},
{
"id": "NCT02334722_inc_T10",
"type": "Scope",
"text": [
"surgical resection or biopsy"
],
"offsets": [
[
76,
104
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02334722_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02334722_inc_T3",
"arg2_id": "NCT02334722_inc_T2",
"normalized": []
},
{
"id": "NCT02334722_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02334722_inc_T1",
"arg2_id": "NCT02334722_inc_T4",
"normalized": []
},
{
"id": "NCT02334722_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT02334722_inc_T10",
"arg2_id": "NCT02334722_inc_T5",
"normalized": []
},
{
"id": "NCT02334722_inc_R4",
"type": "AND",
"arg1_id": "NCT02334722_inc_T10",
"arg2_id": "NCT02334722_inc_T8",
"normalized": []
}
] |
NCT02337764_exc | NCT02337764 | [
{
"id": "NCT02337764_exc_text",
"type": "exclusion",
"text": [
"The participant has Modified Hoehn & Yahr stage 5 (or stage 5 at eather on-time or off-time for the participant with wearing off phenomenon). \nThe participant has severe dyskinesia. \nThe participant has unstable systemic disease. \nThe participant has a Mini-Mental State Examinations (MMSE) score of <= 24. psychiatric disease. \nThe participant has a history of clinically significant hypertension or other reactions associated with ingestion of tyramine-rich food. \nThe participant has received neurosurgical intervention for Parkinson's disease (e.g., pallidotomy, thalamotomy, deep brain stimulation). \nThe participant has received transcranial magnetic stimulation within 6 months.The participant has received selegiline, pethidine, tramadol, reserpine or methyldopa within 90 days. \nThe participant has received levodopa monotherapy, any psychoneurotic agent or antiemetic medication of dopamine agonist within 14 days. However, the participant has been receiving quetiapine or domperidone with a stable dose regimen for >= 14 days may be included in the study. \nThe participant is required to take any of the excluded medications or treatments. \nThe participant with laboratory data meeting any of the following: \nCreatinine >= 2 x upper limit of normal (ULN) \nTotal bilirubin >= 2 x ULN \nALT or AST >= 1.5 x ULN \nALP >= 3 x ULN \nThe participant has received any of the excluded medications or treatments during. \n \n"
],
"offsets": [
[
0,
1431
]
]
}
] | [
{
"id": "NCT02337764_exc_T1",
"type": "Measurement",
"text": [
"Modified Hoehn & Yahr"
],
"offsets": [
[
20,
41
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T2",
"type": "Value",
"text": [
"stage 5"
],
"offsets": [
[
42,
49
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T3",
"type": "Condition",
"text": [
"wearing off phenomenon"
],
"offsets": [
[
117,
139
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T4",
"type": "Temporal",
"text": [
"at",
"on-time"
],
"offsets": [
[
62,
64
],
[
72,
79
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T5",
"type": "Temporal",
"text": [
"at",
"off-time"
],
"offsets": [
[
62,
64
],
[
83,
91
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T6",
"type": "Value",
"text": [
"stage 5"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T7",
"type": "Scope",
"text": [
"at eather on-time or off-time"
],
"offsets": [
[
62,
91
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T8",
"type": "Scope",
"text": [
"stage 5 at eather on-time or off-time for the participant with wearing off phenomenon"
],
"offsets": [
[
54,
139
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T9",
"type": "Condition",
"text": [
"dyskinesia"
],
"offsets": [
[
170,
180
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T10",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
163,
169
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T11",
"type": "Condition",
"text": [
"systemic disease"
],
"offsets": [
[
212,
228
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T13",
"type": "Qualifier",
"text": [
"unstable"
],
"offsets": [
[
203,
211
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T15",
"type": "Measurement",
"text": [
"Mini-Mental State Examinations (MMSE)"
],
"offsets": [
[
253,
290
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T16",
"type": "Value",
"text": [
"<= 24"
],
"offsets": [
[
300,
305
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T17",
"type": "Condition",
"text": [
"psychiatric disease"
],
"offsets": [
[
307,
326
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T19",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
385,
397
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T20",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
362,
384
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T22",
"type": "Condition",
"text": [
"reactions associated with ingestion of tyramine-rich food"
],
"offsets": [
[
407,
464
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T24",
"type": "Procedure",
"text": [
"neurosurgical intervention"
],
"offsets": [
[
496,
522
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T25",
"type": "Condition",
"text": [
"Parkinson's disease"
],
"offsets": [
[
527,
546
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T26",
"type": "Condition",
"text": [
"pallidotomy"
],
"offsets": [
[
554,
565
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T27",
"type": "Condition",
"text": [
"thalamotomy"
],
"offsets": [
[
567,
578
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T28",
"type": "Condition",
"text": [
"deep brain stimulation"
],
"offsets": [
[
580,
602
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T29",
"type": "Scope",
"text": [
"pallidotomy, thalamotomy, deep brain stimulation"
],
"offsets": [
[
554,
602
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T30",
"type": "Scope",
"text": [
"neurosurgical intervention for Parkinson's disease"
],
"offsets": [
[
496,
546
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T31",
"type": "Procedure",
"text": [
"transcranial magnetic stimulation"
],
"offsets": [
[
635,
668
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T32",
"type": "Temporal",
"text": [
"within 6 months"
],
"offsets": [
[
669,
684
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T33",
"type": "Drug",
"text": [
"selegiline"
],
"offsets": [
[
714,
724
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T34",
"type": "Drug",
"text": [
"pethidine"
],
"offsets": [
[
726,
735
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T35",
"type": "Drug",
"text": [
"tramadol"
],
"offsets": [
[
737,
745
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T36",
"type": "Drug",
"text": [
"reserpine"
],
"offsets": [
[
747,
756
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T37",
"type": "Drug",
"text": [
"methyldopa"
],
"offsets": [
[
760,
770
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T38",
"type": "Temporal",
"text": [
"within 90 days"
],
"offsets": [
[
771,
785
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T39",
"type": "Scope",
"text": [
"selegiline, pethidine, tramadol, reserpine or methyldopa"
],
"offsets": [
[
714,
770
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T41",
"type": "Procedure",
"text": [
"levodopa monotherapy"
],
"offsets": [
[
817,
837
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T42",
"type": "Drug",
"text": [
"levodopa"
],
"offsets": [
[
817,
825
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T43",
"type": "Drug",
"text": [
"psychoneurotic agent"
],
"offsets": [
[
843,
863
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T44",
"type": "Drug",
"text": [
"antiemetic medication of dopamine agonist"
],
"offsets": [
[
867,
908
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T45",
"type": "Temporal",
"text": [
"within 14 days"
],
"offsets": [
[
909,
923
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T48",
"type": "Scope",
"text": [
"levodopa monotherapy, any psychoneurotic agent or antiemetic medication of dopamine agonist"
],
"offsets": [
[
817,
908
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T49",
"type": "Drug",
"text": [
"quetiapine"
],
"offsets": [
[
969,
979
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T50",
"type": "Drug",
"text": [
"domperidone"
],
"offsets": [
[
983,
994
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T51",
"type": "Qualifier",
"text": [
"stable dose"
],
"offsets": [
[
1002,
1013
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T52",
"type": "Temporal",
"text": [
">= 14 days"
],
"offsets": [
[
1026,
1036
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T53",
"type": "Scope",
"text": [
"quetiapine or domperidone"
],
"offsets": [
[
969,
994
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T57",
"type": "Measurement",
"text": [
"Creatinine"
],
"offsets": [
[
1220,
1230
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T58",
"type": "Value",
"text": [
">= 2 x upper limit of normal (ULN)"
],
"offsets": [
[
1231,
1265
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T59",
"type": "Measurement",
"text": [
"Total bilirubin"
],
"offsets": [
[
1267,
1282
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T60",
"type": "Value",
"text": [
">= 2 x ULN"
],
"offsets": [
[
1283,
1293
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T61",
"type": "Value",
"text": [
">= 1.5 x ULN"
],
"offsets": [
[
1306,
1318
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T62",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
1302,
1305
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T63",
"type": "Measurement",
"text": [
"ALT"
],
"offsets": [
[
1295,
1298
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T64",
"type": "Scope",
"text": [
"ALT or AST"
],
"offsets": [
[
1295,
1305
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T65",
"type": "Measurement",
"text": [
"ALP"
],
"offsets": [
[
1320,
1323
]
],
"normalized": []
},
{
"id": "NCT02337764_exc_T66",
"type": "Value",
"text": [
">= 3 x ULN"
],
"offsets": [
[
1324,
1334
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02337764_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T1",
"arg2_id": "NCT02337764_exc_T2",
"normalized": []
},
{
"id": "NCT02337764_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T3",
"arg2_id": "NCT02337764_exc_T6",
"normalized": []
},
{
"id": "NCT02337764_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02337764_exc_T6",
"arg2_id": "NCT02337764_exc_T7",
"normalized": []
},
{
"id": "NCT02337764_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02337764_exc_T9",
"arg2_id": "NCT02337764_exc_T10",
"normalized": []
},
{
"id": "NCT02337764_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02337764_exc_T11",
"arg2_id": "NCT02337764_exc_T13",
"normalized": []
},
{
"id": "NCT02337764_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T15",
"arg2_id": "NCT02337764_exc_T16",
"normalized": []
},
{
"id": "NCT02337764_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02337764_exc_T19",
"arg2_id": "NCT02337764_exc_T20",
"normalized": []
},
{
"id": "NCT02337764_exc_R8",
"type": "AND",
"arg1_id": "NCT02337764_exc_T24",
"arg2_id": "NCT02337764_exc_T25",
"normalized": []
},
{
"id": "NCT02337764_exc_R9",
"type": "Subsumes",
"arg1_id": "NCT02337764_exc_T30",
"arg2_id": "NCT02337764_exc_T29",
"normalized": []
},
{
"id": "NCT02337764_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02337764_exc_T31",
"arg2_id": "NCT02337764_exc_T32",
"normalized": []
},
{
"id": "NCT02337764_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02337764_exc_T39",
"arg2_id": "NCT02337764_exc_T38",
"normalized": []
},
{
"id": "NCT02337764_exc_R12",
"type": "AND",
"arg1_id": "NCT02337764_exc_T41",
"arg2_id": "NCT02337764_exc_T42",
"normalized": []
},
{
"id": "NCT02337764_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02337764_exc_T48",
"arg2_id": "NCT02337764_exc_T45",
"normalized": []
},
{
"id": "NCT02337764_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT02337764_exc_T51",
"arg2_id": "NCT02337764_exc_T52",
"normalized": []
},
{
"id": "NCT02337764_exc_R15",
"type": "Has_qualifier",
"arg1_id": "NCT02337764_exc_T53",
"arg2_id": "NCT02337764_exc_T51",
"normalized": []
},
{
"id": "NCT02337764_exc_R16",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T57",
"arg2_id": "NCT02337764_exc_T58",
"normalized": []
},
{
"id": "NCT02337764_exc_R17",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T59",
"arg2_id": "NCT02337764_exc_T60",
"normalized": []
},
{
"id": "NCT02337764_exc_R18",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T64",
"arg2_id": "NCT02337764_exc_T61",
"normalized": []
},
{
"id": "NCT02337764_exc_R19",
"type": "Has_value",
"arg1_id": "NCT02337764_exc_T65",
"arg2_id": "NCT02337764_exc_T66",
"normalized": []
}
] |
NCT02337764_inc | NCT02337764 | [
{
"id": "NCT02337764_inc_text",
"type": "inclusion",
"text": [
"The participant has a diagnosis of Parkinson's disease according to the diagnostic criteria of the UK Parkinson's Disease Society Brain Bank. \nThe participant has received a levodopa combination drug for >= 1 month and has either of the following. \nWearing off phenomenon \nDecreased response to levodopa combination drugs \nThe participant has received a levodopa combination drug without change in the dose regimen. \nThe participant is an outpatient of either sex aged >= 30 and < 80 years. \n"
],
"offsets": [
[
0,
492
]
]
}
] | [
{
"id": "NCT02337764_inc_T1",
"type": "Condition",
"text": [
"Parkinson's disease"
],
"offsets": [
[
35,
54
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T2",
"type": "Measurement",
"text": [
"UK Parkinson's Disease Society Brain Bank"
],
"offsets": [
[
99,
140
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T3",
"type": "Drug",
"text": [
"levodopa combination"
],
"offsets": [
[
174,
194
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T4",
"type": "Temporal",
"text": [
">= 1 month"
],
"offsets": [
[
204,
214
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T6",
"type": "Condition",
"text": [
"Wearing off phenomenon"
],
"offsets": [
[
249,
271
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T7",
"type": "Condition",
"text": [
"Decreased response"
],
"offsets": [
[
273,
291
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T8",
"type": "Drug",
"text": [
"evodopa combination drugs"
],
"offsets": [
[
296,
321
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T9",
"type": "Drug",
"text": [
"levodopa combination drug"
],
"offsets": [
[
354,
379
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T10",
"type": "Qualifier",
"text": [
"without change in the dose regimen"
],
"offsets": [
[
380,
414
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T11",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
464,
468
]
],
"normalized": []
},
{
"id": "NCT02337764_inc_T12",
"type": "Value",
"text": [
">= 30 and < 80 years"
],
"offsets": [
[
469,
489
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02337764_inc_R1",
"type": "AND",
"arg1_id": "NCT02337764_inc_T1",
"arg2_id": "NCT02337764_inc_T2",
"normalized": []
},
{
"id": "NCT02337764_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02337764_inc_T3",
"arg2_id": "NCT02337764_inc_T4",
"normalized": []
},
{
"id": "NCT02337764_inc_R3",
"type": "AND",
"arg1_id": "NCT02337764_inc_T7",
"arg2_id": "NCT02337764_inc_T8",
"normalized": []
},
{
"id": "NCT02337764_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02337764_inc_T9",
"arg2_id": "NCT02337764_inc_T10",
"normalized": []
},
{
"id": "NCT02337764_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02337764_inc_T11",
"arg2_id": "NCT02337764_inc_T12",
"normalized": []
}
] |
NCT02339844_exc | NCT02339844 | [
{
"id": "NCT02339844_exc_text",
"type": "exclusion",
"text": [
"Exclusion Criteria patients: Substance abuse on a daily basis during the last 3 month or patients fulfilling the criteria of ongoing substance abuse due to ICD-10/DSM-IV/V, Treatment with antidepressant during the last 30 days, Head injury with more than 5 minutes of unconsciousness, Patients involuntarily admitted or treated, Components of metal implanted by operation, Pacemaker, Pregnancy, Severe physical illness\nExclusion criteria controls: First degree relatives with psychiatric disease, Substance abuse during the last 3 month or positive screening of drugs in urine-sample, Head injury with more than 5 minutes of unconsciousness, Components of metal implanted by operation, Pacemaker, Pregnancy, Severe physical illness\n"
],
"offsets": [
[
0,
732
]
]
}
] | [
{
"id": "NCT02339844_exc_T1",
"type": "Observation",
"text": [
"patients"
],
"offsets": [
[
19,
27
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T2",
"type": "Condition",
"text": [
"Substance abuse"
],
"offsets": [
[
29,
44
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T3",
"type": "Multiplier",
"text": [
"daily basis"
],
"offsets": [
[
50,
61
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T4",
"type": "Multiplier",
"text": [
"during the last 3 month"
],
"offsets": [
[
62,
85
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T5",
"type": "Qualifier",
"text": [
"ICD-10/DSM-IV/V"
],
"offsets": [
[
156,
171
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T6",
"type": "Condition",
"text": [
"substance abuse"
],
"offsets": [
[
133,
148
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T7",
"type": "Temporal",
"text": [
"ongoing"
],
"offsets": [
[
125,
132
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T8",
"type": "Drug",
"text": [
"antidepressant"
],
"offsets": [
[
188,
202
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T9",
"type": "Temporal",
"text": [
"during the last 30 days"
],
"offsets": [
[
203,
226
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T10",
"type": "Condition",
"text": [
"Head injury"
],
"offsets": [
[
228,
239
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T11",
"type": "Multiplier",
"text": [
"more than 5 minutes"
],
"offsets": [
[
245,
264
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T12",
"type": "Condition",
"text": [
"unconsciousness"
],
"offsets": [
[
268,
283
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T13",
"type": "Observation",
"text": [
"involuntarily admitted"
],
"offsets": [
[
294,
316
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T14",
"type": "Observation",
"text": [
"involuntarily",
"treated"
],
"offsets": [
[
294,
307
],
[
320,
327
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T15",
"type": "Device",
"text": [
"Components of metal"
],
"offsets": [
[
329,
348
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T16",
"type": "Device",
"text": [
"Pacemaker"
],
"offsets": [
[
373,
382
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T17",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
384,
393
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T18",
"type": "Condition",
"text": [
"Severe physical illness"
],
"offsets": [
[
395,
418
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T19",
"type": "Scope",
"text": [
"Substance abuse on a daily basis during the last 3 month or patients fulfilling the criteria of ongoing substance abuse due to ICD-10/DSM-IV/V, Treatment with antidepressant during the last 30 days, Head injury with more than 5 minutes of unconsciousness, Patients involuntarily admitted or treated, Components of metal implanted by operation, Pacemaker, Pregnancy, Severe physical illness"
],
"offsets": [
[
29,
418
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T20",
"type": "Observation",
"text": [
"controls"
],
"offsets": [
[
438,
446
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T21",
"type": "Observation",
"text": [
"First degree relatives"
],
"offsets": [
[
448,
470
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T22",
"type": "Condition",
"text": [
"psychiatric disease"
],
"offsets": [
[
476,
495
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T23",
"type": "Condition",
"text": [
"Substance abuse"
],
"offsets": [
[
497,
512
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T24",
"type": "Temporal",
"text": [
"during the last 3 month"
],
"offsets": [
[
513,
536
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T25",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
540,
548
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T26",
"type": "Procedure",
"text": [
"screening of drugs"
],
"offsets": [
[
549,
567
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T27",
"type": "Qualifier",
"text": [
"urine-sample"
],
"offsets": [
[
571,
583
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T28",
"type": "Condition",
"text": [
"Head injury"
],
"offsets": [
[
585,
596
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T29",
"type": "Multiplier",
"text": [
"more than 5 minutes"
],
"offsets": [
[
602,
621
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T30",
"type": "Condition",
"text": [
"unconsciousness"
],
"offsets": [
[
625,
640
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T31",
"type": "Device",
"text": [
"Components of metal"
],
"offsets": [
[
642,
661
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T32",
"type": "Device",
"text": [
"Pacemaker"
],
"offsets": [
[
686,
695
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T33",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
697,
706
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T34",
"type": "Condition",
"text": [
"Severe physical illness"
],
"offsets": [
[
708,
731
]
],
"normalized": []
},
{
"id": "NCT02339844_exc_T35",
"type": "Scope",
"text": [
"First degree relatives with psychiatric disease, Substance abuse during the last 3 month or positive screening of drugs in urine-sample, Head injury with more than 5 minutes of unconsciousness, Components of metal implanted by operation, Pacemaker, Pregnancy, Severe physical illness"
],
"offsets": [
[
448,
731
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02339844_exc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02339844_exc_T2",
"arg2_id": "NCT02339844_exc_T3",
"normalized": []
},
{
"id": "NCT02339844_exc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02339844_exc_T2",
"arg2_id": "NCT02339844_exc_T4",
"normalized": []
},
{
"id": "NCT02339844_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02339844_exc_T6",
"arg2_id": "NCT02339844_exc_T7",
"normalized": []
},
{
"id": "NCT02339844_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02339844_exc_T6",
"arg2_id": "NCT02339844_exc_T5",
"normalized": []
},
{
"id": "NCT02339844_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02339844_exc_T8",
"arg2_id": "NCT02339844_exc_T9",
"normalized": []
},
{
"id": "NCT02339844_exc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02339844_exc_T12",
"arg2_id": "NCT02339844_exc_T11",
"normalized": []
},
{
"id": "NCT02339844_exc_R7",
"type": "AND",
"arg1_id": "NCT02339844_exc_T10",
"arg2_id": "NCT02339844_exc_T12",
"normalized": []
},
{
"id": "NCT02339844_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT02339844_exc_T1",
"arg2_id": "NCT02339844_exc_T19",
"normalized": []
},
{
"id": "NCT02339844_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02339844_exc_T23",
"arg2_id": "NCT02339844_exc_T24",
"normalized": []
},
{
"id": "NCT02339844_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02339844_exc_T26",
"arg2_id": "NCT02339844_exc_T27",
"normalized": []
},
{
"id": "NCT02339844_exc_R12",
"type": "Has_value",
"arg1_id": "NCT02339844_exc_T26",
"arg2_id": "NCT02339844_exc_T25",
"normalized": []
},
{
"id": "NCT02339844_exc_R13",
"type": "Has_multiplier",
"arg1_id": "NCT02339844_exc_T30",
"arg2_id": "NCT02339844_exc_T29",
"normalized": []
},
{
"id": "NCT02339844_exc_R14",
"type": "AND",
"arg1_id": "NCT02339844_exc_T28",
"arg2_id": "NCT02339844_exc_T30",
"normalized": []
},
{
"id": "NCT02339844_exc_R15",
"type": "Has_scope",
"arg1_id": "NCT02339844_exc_T20",
"arg2_id": "NCT02339844_exc_T35",
"normalized": []
}
] |
NCT02339844_inc | NCT02339844 | [
{
"id": "NCT02339844_inc_text",
"type": "inclusion",
"text": [
"Inclusion Criteria Patients: Fulfilling the diagnostic criteria of schizophrenia or schizoaffective disorder according to ICD-10 (International Classification of Diseases version 10) or DSM-IV/V (Diagnostic and Statistical Manual version 4 /5), Age 18-45 years, Never treated with antipsychotic compounds or central nervous system (CNS) stimulants, Legally competent\nInclusion criteria controls: Matching patients on age (+/- 2 years), sex and parental socioeconomic status, Age 18-45 years, No psychiatric or physical disease.\n"
],
"offsets": [
[
0,
528
]
]
}
] | [
{
"id": "NCT02339844_inc_T1",
"type": "Observation",
"text": [
"Patients"
],
"offsets": [
[
19,
27
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T2",
"type": "Observation",
"text": [
"controls"
],
"offsets": [
[
386,
394
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T3",
"type": "Condition",
"text": [
"schizophrenia"
],
"offsets": [
[
67,
80
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T4",
"type": "Condition",
"text": [
"schizoaffective disorder"
],
"offsets": [
[
84,
108
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T5",
"type": "Qualifier",
"text": [
"ICD-10 (International Classification of Diseases version 10)"
],
"offsets": [
[
122,
182
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T6",
"type": "Qualifier",
"text": [
"DSM-IV/V (Diagnostic and Statistical Manual version 4 /5)"
],
"offsets": [
[
186,
243
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T7",
"type": "Scope",
"text": [
"ICD-10 (International Classification of Diseases version 10) or DSM-IV/V (Diagnostic and Statistical Manual version 4 /5)"
],
"offsets": [
[
122,
243
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T8",
"type": "Scope",
"text": [
"schizophrenia or schizoaffective disorder"
],
"offsets": [
[
67,
108
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T9",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
245,
248
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T10",
"type": "Value",
"text": [
"18-45 years"
],
"offsets": [
[
249,
260
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T11",
"type": "Negation",
"text": [
"Never"
],
"offsets": [
[
262,
267
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T12",
"type": "Drug",
"text": [
"antipsychotic compounds"
],
"offsets": [
[
281,
304
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T13",
"type": "Drug",
"text": [
"central nervous system (CNS) stimulants"
],
"offsets": [
[
308,
347
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T14",
"type": "Observation",
"text": [
"Legally competent"
],
"offsets": [
[
349,
366
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T15",
"type": "Scope",
"text": [
"schizophrenia or schizoaffective disorder according to ICD-10 (International Classification of Diseases version 10) or DSM-IV/V (Diagnostic and Statistical Manual version 4 /5), Age 18-45 years, Never treated with antipsychotic compounds or central nervous system (CNS) stimulants, Legally competent"
],
"offsets": [
[
67,
366
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T17",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
475,
478
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T18",
"type": "Value",
"text": [
"18-45 years"
],
"offsets": [
[
479,
490
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T19",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
492,
494
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T20",
"type": "Condition",
"text": [
"sychiatric",
"isease."
],
"offsets": [
[
496,
506
],
[
520,
527
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T21",
"type": "Condition",
"text": [
"physical disease"
],
"offsets": [
[
510,
526
]
],
"normalized": []
},
{
"id": "NCT02339844_inc_T22",
"type": "Scope",
"text": [
"Matching patients on age (+/- 2 years), sex and parental socioeconomic status, Age 18-45 years, No psychiatric or physical disease"
],
"offsets": [
[
396,
526
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02339844_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT02339844_inc_T8",
"arg2_id": "NCT02339844_inc_T7",
"normalized": []
},
{
"id": "NCT02339844_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02339844_inc_T9",
"arg2_id": "NCT02339844_inc_T10",
"normalized": []
},
{
"id": "NCT02339844_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT02339844_inc_T12",
"arg2_id": "NCT02339844_inc_T11",
"normalized": []
},
{
"id": "NCT02339844_inc_R4",
"type": "Has_negation",
"arg1_id": "NCT02339844_inc_T13",
"arg2_id": "NCT02339844_inc_T11",
"normalized": []
},
{
"id": "NCT02339844_inc_R5",
"type": "Has_scope",
"arg1_id": "NCT02339844_inc_T1",
"arg2_id": "NCT02339844_inc_T15",
"normalized": []
},
{
"id": "NCT02339844_inc_R6",
"type": "Has_negation",
"arg1_id": "NCT02339844_inc_T20",
"arg2_id": "NCT02339844_inc_T19",
"normalized": []
},
{
"id": "NCT02339844_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT02339844_inc_T21",
"arg2_id": "NCT02339844_inc_T19",
"normalized": []
},
{
"id": "NCT02339844_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02339844_inc_T17",
"arg2_id": "NCT02339844_inc_T18",
"normalized": []
},
{
"id": "NCT02339844_inc_R9",
"type": "Has_scope",
"arg1_id": "NCT02339844_inc_T2",
"arg2_id": "NCT02339844_inc_T22",
"normalized": []
}
] |
NCT02339974_exc | NCT02339974 | [
{
"id": "NCT02339974_exc_text",
"type": "exclusion",
"text": [
"Heart Team assessment of operability (the heart team considers the patient to be a good surgical candidate).\nEvidence of an acute myocardial infarction = 1 month (30 days) before the intended treatment [defined as: Q wave MI, or non-Q wave MI with total CK elevation of CK-MB = twice normal in the presence of MB elevation and/or troponin level elevation (WHO definition)].\nUntreated, severe, left sided valvular heart disease including mitral regurgitation or stenosis, and aortic regurgitation or stenosis.\nMean pulmonary artery pressures =40mmHG and PVR >4 woods units as assessed by right heart catheterization.\nAny therapeutic invasive cardiac procedure resulting in a permanent implant that is performed within 30 days of the index procedure. Examples of permanent implant would include any new heart valve. Implantation of a permanent pacemaker is excluded.\nPatients with planned concomitant surgical or transcatheter ablation for Atrial Fibrillation.\nLeukopenia (WBC < 3000 cell/mL), acute anemia (Hgb < 9 g/dL), Thrombocytopenia (Plt < 50,000 cell/mL).\nHemodynamic or respiratory instability requiring inotropic support, mechanical ventilation or mechanical heart assistance within 30 days of screening evaluation.\nNeed for emergency surgery for any reason.\nLeft ventricular ejection fraction <40%.\nEchocardiographic evidence of intracardiac mass, thrombus or vegetation.\nActive upper GI bleeding within 3 months (90 days) prior to procedure.\nA known contraindication or hypersensitivity to all anticoagulation regimens, or inability to be anticoagulated for the study procedure.\nRecent CVA clinically confirmed (by neurologist) or neuroimaging confirmed stroke or transient ischemic attack (TIA) within 6 months (180 days) of the procedure.\nEstimated life expectancy < 1 year from conditions other than TR.\nExpectation that patient will not improve despite treatment of tricuspid regurgitation\nCurrently participating in another investigational cardiac device study or any other clinical trial, including drugs or biologics. Note: Trials requiring extended follow-up for products that were investigational, but have since become commercially available, are not considered investigational trials.\nActive bacterial endocarditis within 6 months (180 days) of procedure.\nPatients with signs or symptoms of SVC syndrome, or hepatic cirrhosis not felt due to passive congestion from TR.\n"
],
"offsets": [
[
0,
2391
]
]
}
] | [
{
"id": "NCT02339974_exc_T1",
"type": "Condition",
"text": [
"heart team considers the patient to be a good surgical candidate"
],
"offsets": [
[
42,
106
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T2",
"type": "Procedure",
"text": [
"Heart Team assessment of operability"
],
"offsets": [
[
0,
36
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T3",
"type": "Condition",
"text": [
"acute myocardial infarction"
],
"offsets": [
[
124,
151
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T4",
"type": "Temporal",
"text": [
"= 1 month (30 days) before the intended treatment"
],
"offsets": [
[
152,
201
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T5",
"type": "Condition",
"text": [
"valvular heart disease"
],
"offsets": [
[
404,
426
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T6",
"type": "Qualifier",
"text": [
"left sided"
],
"offsets": [
[
393,
403
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T7",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
385,
391
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T8",
"type": "Qualifier",
"text": [
"Untreated"
],
"offsets": [
[
374,
383
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T9",
"type": "Condition",
"text": [
"mitral regurgitation"
],
"offsets": [
[
437,
457
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T10",
"type": "Condition",
"text": [
"tral r",
"enosis,"
],
"offsets": [
[
439,
445
],
[
463,
470
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T11",
"type": "Condition",
"text": [
"aortic regurgitation"
],
"offsets": [
[
475,
495
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T12",
"type": "Condition",
"text": [
"rtic r",
"enosis."
],
"offsets": [
[
477,
483
],
[
501,
508
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T13",
"type": "Scope",
"text": [
"mitral regurgitation or stenosis, and aortic regurgitation or stenosis"
],
"offsets": [
[
437,
507
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T14",
"type": "Measurement",
"text": [
"Mean pulmonary artery pressures"
],
"offsets": [
[
509,
540
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T15",
"type": "Value",
"text": [
"=40mmHG"
],
"offsets": [
[
541,
548
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T16",
"type": "Measurement",
"text": [
"PVR"
],
"offsets": [
[
553,
556
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T17",
"type": "Value",
"text": [
">4 woods units"
],
"offsets": [
[
557,
571
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T18",
"type": "Condition",
"text": [
"right heart catheterization"
],
"offsets": [
[
587,
614
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T19",
"type": "Scope",
"text": [
"Mean pulmonary artery pressures =40mmHG and PVR >4 woods units"
],
"offsets": [
[
509,
571
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T20",
"type": "Procedure",
"text": [
"cardiac procedure"
],
"offsets": [
[
641,
658
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T21",
"type": "Qualifier",
"text": [
"invasive"
],
"offsets": [
[
632,
640
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T22",
"type": "Qualifier",
"text": [
"therapeutic"
],
"offsets": [
[
620,
631
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T23",
"type": "Device",
"text": [
"permanent implant"
],
"offsets": [
[
674,
691
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T24",
"type": "Temporal",
"text": [
"within 30 days of the index procedure"
],
"offsets": [
[
710,
747
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T25",
"type": "Reference_point",
"text": [
"the index procedure"
],
"offsets": [
[
728,
747
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T26",
"type": "Device",
"text": [
"heart valve"
],
"offsets": [
[
801,
812
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T27",
"type": "Device",
"text": [
"permanent pacemaker"
],
"offsets": [
[
832,
851
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T28",
"type": "Negation",
"text": [
"excluded"
],
"offsets": [
[
855,
863
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T29",
"type": "Procedure",
"text": [
"cal or t",
"ion for"
],
"offsets": [
[
904,
912
],
[
930,
937
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T30",
"type": "Procedure",
"text": [
"transcatheter ablation"
],
"offsets": [
[
911,
933
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T31",
"type": "Condition",
"text": [
"Atrial Fibrillation"
],
"offsets": [
[
938,
957
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T32",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
879,
886
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T33",
"type": "Temporal",
"text": [
"concomitant"
],
"offsets": [
[
887,
898
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T34",
"type": "Scope",
"text": [
"surgical or transcatheter ablation"
],
"offsets": [
[
899,
933
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T35",
"type": "Condition",
"text": [
"Leukopenia"
],
"offsets": [
[
959,
969
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T36",
"type": "Measurement",
"text": [
"WBC"
],
"offsets": [
[
971,
974
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T37",
"type": "Value",
"text": [
"< 3000 cell/mL"
],
"offsets": [
[
975,
989
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T38",
"type": "Condition",
"text": [
"acute anemia"
],
"offsets": [
[
992,
1004
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T39",
"type": "Measurement",
"text": [
"Hgb"
],
"offsets": [
[
1006,
1009
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T40",
"type": "Value",
"text": [
"< 9 g/dL"
],
"offsets": [
[
1010,
1018
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T41",
"type": "Condition",
"text": [
"Thrombocytopenia"
],
"offsets": [
[
1021,
1037
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T42",
"type": "Measurement",
"text": [
"Plt"
],
"offsets": [
[
1039,
1042
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T43",
"type": "Value",
"text": [
"< 50,000 cell/mL"
],
"offsets": [
[
1043,
1059
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T44",
"type": "Condition",
"text": [
"respiratory instability"
],
"offsets": [
[
1077,
1100
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T45",
"type": "Procedure",
"text": [
"inotropic support"
],
"offsets": [
[
1111,
1128
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T46",
"type": "Condition",
"text": [
"amic or res",
"lity requir"
],
"offsets": [
[
1069,
1080
],
[
1096,
1107
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T47",
"type": "Procedure",
"text": [
"mechanical ventilation"
],
"offsets": [
[
1130,
1152
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T48",
"type": "Procedure",
"text": [
"mechanical heart assistance"
],
"offsets": [
[
1156,
1183
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T49",
"type": "Temporal",
"text": [
"within 30 days of screening evaluation"
],
"offsets": [
[
1184,
1222
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T50",
"type": "Reference_point",
"text": [
"screening evaluation"
],
"offsets": [
[
1202,
1222
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T51",
"type": "Scope",
"text": [
"inotropic support, mechanical ventilation or mechanical heart assistance"
],
"offsets": [
[
1111,
1183
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T52",
"type": "Scope",
"text": [
"Hemodynamic or respiratory instability"
],
"offsets": [
[
1062,
1100
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T53",
"type": "Procedure",
"text": [
"emergency surgery"
],
"offsets": [
[
1233,
1250
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T54",
"type": "Mood",
"text": [
"Need for"
],
"offsets": [
[
1224,
1232
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T55",
"type": "Measurement",
"text": [
"Left ventricular ejection fraction"
],
"offsets": [
[
1267,
1301
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T56",
"type": "Value",
"text": [
"<40%"
],
"offsets": [
[
1302,
1306
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T57",
"type": "Procedure",
"text": [
"Echocardiographic"
],
"offsets": [
[
1308,
1325
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T58",
"type": "Condition",
"text": [
"intracardiac mass"
],
"offsets": [
[
1338,
1355
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T59",
"type": "Condition",
"text": [
"ac mass, thr",
"r vegeta"
],
"offsets": [
[
1348,
1360
],
[
1367,
1375
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T60",
"type": "Condition",
"text": [
"ac mass, thr",
".\nActive u"
],
"offsets": [
[
1348,
1360
],
[
1379,
1389
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T61",
"type": "Scope",
"text": [
"intracardiac mass, thrombus or vegetation"
],
"offsets": [
[
1338,
1379
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T62",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
1381,
1387
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T63",
"type": "Condition",
"text": [
"upper GI bleeding"
],
"offsets": [
[
1388,
1405
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T64",
"type": "Temporal",
"text": [
"within 3 months (90 days) prior to procedure"
],
"offsets": [
[
1406,
1450
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T65",
"type": "Reference_point",
"text": [
"procedure"
],
"offsets": [
[
1441,
1450
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T66",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
1460,
1476
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T67",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
1480,
1496
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T68",
"type": "Procedure",
"text": [
"anticoagulation regimens"
],
"offsets": [
[
1504,
1528
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T69",
"type": "Condition",
"text": [
"inability"
],
"offsets": [
[
1533,
1542
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T70",
"type": "Procedure",
"text": [
"anticoagulated"
],
"offsets": [
[
1549,
1563
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T71",
"type": "Temporal",
"text": [
"for the study procedure"
],
"offsets": [
[
1564,
1587
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T72",
"type": "Reference_point",
"text": [
"study procedure"
],
"offsets": [
[
1572,
1587
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T73",
"type": "Scope",
"text": [
"contraindication or hypersensitivity"
],
"offsets": [
[
1460,
1496
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T74",
"type": "Condition",
"text": [
"CVA"
],
"offsets": [
[
1596,
1599
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T75",
"type": "Procedure",
"text": [
"neuroimaging"
],
"offsets": [
[
1641,
1653
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T76",
"type": "Value",
"text": [
"confirmed"
],
"offsets": [
[
1654,
1663
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T77",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
1664,
1670
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T78",
"type": "Condition",
"text": [
"transient ischemic attack (TIA)"
],
"offsets": [
[
1674,
1705
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T79",
"type": "Scope",
"text": [
"stroke or transient ischemic attack (TIA)"
],
"offsets": [
[
1664,
1705
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T80",
"type": "Qualifier",
"text": [
"clinically confirmed (by neurologist)"
],
"offsets": [
[
1600,
1637
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T81",
"type": "Temporal",
"text": [
"within 6 months (180 days) of the procedure"
],
"offsets": [
[
1706,
1749
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T82",
"type": "Reference_point",
"text": [
"the procedure"
],
"offsets": [
[
1736,
1749
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T83",
"type": "Observation",
"text": [
"Estimated life expectancy"
],
"offsets": [
[
1751,
1776
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T84",
"type": "Value",
"text": [
"< 1 year"
],
"offsets": [
[
1777,
1785
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T87",
"type": "Condition",
"text": [
"bacterial endocarditis"
],
"offsets": [
[
2213,
2235
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T88",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
2206,
2212
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T89",
"type": "Temporal",
"text": [
"within 6 months (180 days) of procedure"
],
"offsets": [
[
2236,
2275
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T90",
"type": "Reference_point",
"text": [
"of procedure"
],
"offsets": [
[
2263,
2275
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T91",
"type": "Condition",
"text": [
"SVC syndrome"
],
"offsets": [
[
2312,
2324
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T92",
"type": "Condition",
"text": [
"hepatic cirrhosis"
],
"offsets": [
[
2329,
2346
]
],
"normalized": []
},
{
"id": "NCT02339974_exc_T93",
"type": "Condition",
"text": [
"passive congestion from TR"
],
"offsets": [
[
2363,
2389
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02339974_exc_R1",
"type": "AND",
"arg1_id": "NCT02339974_exc_T1",
"arg2_id": "NCT02339974_exc_T2",
"normalized": []
},
{
"id": "NCT02339974_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T5",
"arg2_id": "NCT02339974_exc_T6",
"normalized": []
},
{
"id": "NCT02339974_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T5",
"arg2_id": "NCT02339974_exc_T7",
"normalized": []
},
{
"id": "NCT02339974_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T5",
"arg2_id": "NCT02339974_exc_T8",
"normalized": []
},
{
"id": "NCT02339974_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02339974_exc_T5",
"arg2_id": "NCT02339974_exc_T13",
"normalized": []
},
{
"id": "NCT02339974_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T14",
"arg2_id": "NCT02339974_exc_T15",
"normalized": []
},
{
"id": "NCT02339974_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T16",
"arg2_id": "NCT02339974_exc_T17",
"normalized": []
},
{
"id": "NCT02339974_exc_R8",
"type": "AND",
"arg1_id": "NCT02339974_exc_T19",
"arg2_id": "NCT02339974_exc_T18",
"normalized": []
},
{
"id": "NCT02339974_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T20",
"arg2_id": "NCT02339974_exc_T21",
"normalized": []
},
{
"id": "NCT02339974_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T20",
"arg2_id": "NCT02339974_exc_T22",
"normalized": []
},
{
"id": "NCT02339974_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T24",
"arg2_id": "NCT02339974_exc_T25",
"normalized": []
},
{
"id": "NCT02339974_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT02339974_exc_T23",
"arg2_id": "NCT02339974_exc_T26",
"normalized": []
},
{
"id": "NCT02339974_exc_R13",
"type": "AND",
"arg1_id": "NCT02339974_exc_T20",
"arg2_id": "NCT02339974_exc_T23",
"normalized": []
},
{
"id": "NCT02339974_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T20",
"arg2_id": "NCT02339974_exc_T24",
"normalized": []
},
{
"id": "NCT02339974_exc_R15",
"type": "Has_negation",
"arg1_id": "NCT02339974_exc_T27",
"arg2_id": "NCT02339974_exc_T28",
"normalized": []
},
{
"id": "NCT02339974_exc_R16",
"type": "AND",
"arg1_id": "NCT02339974_exc_T23",
"arg2_id": "NCT02339974_exc_T27",
"normalized": []
},
{
"id": "NCT02339974_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T34",
"arg2_id": "NCT02339974_exc_T33",
"normalized": []
},
{
"id": "NCT02339974_exc_R18",
"type": "Has_mood",
"arg1_id": "NCT02339974_exc_T34",
"arg2_id": "NCT02339974_exc_T32",
"normalized": []
},
{
"id": "NCT02339974_exc_R19",
"type": "AND",
"arg1_id": "NCT02339974_exc_T34",
"arg2_id": "NCT02339974_exc_T31",
"normalized": []
},
{
"id": "NCT02339974_exc_R20",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T36",
"arg2_id": "NCT02339974_exc_T37",
"normalized": []
},
{
"id": "NCT02339974_exc_R21",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T39",
"arg2_id": "NCT02339974_exc_T40",
"normalized": []
},
{
"id": "NCT02339974_exc_R22",
"type": "Subsumes",
"arg1_id": "NCT02339974_exc_T38",
"arg2_id": "NCT02339974_exc_T39",
"normalized": []
},
{
"id": "NCT02339974_exc_R23",
"type": "Subsumes",
"arg1_id": "NCT02339974_exc_T35",
"arg2_id": "NCT02339974_exc_T36",
"normalized": []
},
{
"id": "NCT02339974_exc_R24",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T42",
"arg2_id": "NCT02339974_exc_T43",
"normalized": []
},
{
"id": "NCT02339974_exc_R25",
"type": "Subsumes",
"arg1_id": "NCT02339974_exc_T41",
"arg2_id": "NCT02339974_exc_T42",
"normalized": []
},
{
"id": "NCT02339974_exc_R26",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T49",
"arg2_id": "NCT02339974_exc_T50",
"normalized": []
},
{
"id": "NCT02339974_exc_R27",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T51",
"arg2_id": "NCT02339974_exc_T49",
"normalized": []
},
{
"id": "NCT02339974_exc_R28",
"type": "Has_scope",
"arg1_id": "NCT02339974_exc_T52",
"arg2_id": "NCT02339974_exc_T51",
"normalized": []
},
{
"id": "NCT02339974_exc_R29",
"type": "Has_mood",
"arg1_id": "NCT02339974_exc_T53",
"arg2_id": "NCT02339974_exc_T54",
"normalized": []
},
{
"id": "NCT02339974_exc_R30",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T55",
"arg2_id": "NCT02339974_exc_T56",
"normalized": []
},
{
"id": "NCT02339974_exc_R31",
"type": "Has_scope",
"arg1_id": "NCT02339974_exc_T57",
"arg2_id": "NCT02339974_exc_T61",
"normalized": []
},
{
"id": "NCT02339974_exc_R32",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T63",
"arg2_id": "NCT02339974_exc_T62",
"normalized": []
},
{
"id": "NCT02339974_exc_R33",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T64",
"arg2_id": "NCT02339974_exc_T65",
"normalized": []
},
{
"id": "NCT02339974_exc_R34",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T71",
"arg2_id": "NCT02339974_exc_T72",
"normalized": []
},
{
"id": "NCT02339974_exc_R35",
"type": "AND",
"arg1_id": "NCT02339974_exc_T69",
"arg2_id": "NCT02339974_exc_T70",
"normalized": []
},
{
"id": "NCT02339974_exc_R36",
"type": "AND",
"arg1_id": "NCT02339974_exc_T73",
"arg2_id": "NCT02339974_exc_T68",
"normalized": []
},
{
"id": "NCT02339974_exc_R37",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T69",
"arg2_id": "NCT02339974_exc_T71",
"normalized": []
},
{
"id": "NCT02339974_exc_R38",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T75",
"arg2_id": "NCT02339974_exc_T76",
"normalized": []
},
{
"id": "NCT02339974_exc_R39",
"type": "AND",
"arg1_id": "NCT02339974_exc_T79",
"arg2_id": "NCT02339974_exc_T75",
"normalized": []
},
{
"id": "NCT02339974_exc_R40",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_exc_T74",
"arg2_id": "NCT02339974_exc_T80",
"normalized": []
},
{
"id": "NCT02339974_exc_R41",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T81",
"arg2_id": "NCT02339974_exc_T82",
"normalized": []
},
{
"id": "NCT02339974_exc_R42",
"type": "Has_value",
"arg1_id": "NCT02339974_exc_T83",
"arg2_id": "NCT02339974_exc_T84",
"normalized": []
},
{
"id": "NCT02339974_exc_R43",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T87",
"arg2_id": "NCT02339974_exc_T88",
"normalized": []
},
{
"id": "NCT02339974_exc_R44",
"type": "Has_temporal",
"arg1_id": "NCT02339974_exc_T87",
"arg2_id": "NCT02339974_exc_T89",
"normalized": []
},
{
"id": "NCT02339974_exc_R45",
"type": "Has_index",
"arg1_id": "NCT02339974_exc_T89",
"arg2_id": "NCT02339974_exc_T90",
"normalized": []
},
{
"id": "NCT02339974_exc_R46",
"type": "AND",
"arg1_id": "NCT02339974_exc_T92",
"arg2_id": "NCT02339974_exc_T93",
"normalized": []
}
] |
NCT02339974_inc | NCT02339974 | [
{
"id": "NCT02339974_inc_text",
"type": "inclusion",
"text": [
"Patients must be at least 21 years old.\nThe patient must have severe, symptomatic (ACC/AHA Stage D symptoms) tricuspid regurgitation (TR) as assessed by 2D echocardiogram with evidence of peripheral and central venous congestion (specifically lower extremity edema and abdominal ascites requiring diuretics.)\nThe patient must be evaluated by a \"heart team\" of physicians including an interventional cardiologist, cardiothoracic surgeon, heart failure specialist, and imaging specialist, and presented for review at a local multi-disciplinary conference. By consensus, the heart team must agree (and verify in the case review process) that valve implantation will likely benefit the patient.\nThe heart team must agree that medical factors preclude operation, based on a conclusion that the probability of death or serious, irreversible morbidity exceeds the probability of meaningful improvement. Also, other factors which may increase the patients perceived surgical risk for inclusion in the trial will be clearly delineated if they are present. These include, but are not limited to the following as defined by VARC 2: Frailty, Hostile chest, porcelain aorta, IMA or other critical conduit crossing the midline or adherent to the posterior table of sternum, severe right ventricular (RV) dysfunction. The surgeons' consultation notes shall specify the medical or anatomic factors leading to that conclusion. At least one of the cardiac surgeon assessors must have interviewed and examined the patient.\nThe study patient provides informed consent and agrees to comply with all required post-procedure follow-up visits, including annual visits up to 5 years.\n"
],
"offsets": [
[
0,
1659
]
]
}
] | [
{
"id": "NCT02339974_inc_T1",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T2",
"type": "Value",
"text": [
"at least 21 years"
],
"offsets": [
[
17,
34
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T3",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
62,
68
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T4",
"type": "Qualifier",
"text": [
"symptomatic"
],
"offsets": [
[
70,
81
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T5",
"type": "Condition",
"text": [
"tricuspid regurgitation"
],
"offsets": [
[
109,
132
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T6",
"type": "Condition",
"text": [
"TR"
],
"offsets": [
[
134,
136
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T7",
"type": "Measurement",
"text": [
"ACC/AHA"
],
"offsets": [
[
83,
90
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T8",
"type": "Value",
"text": [
"Stage D"
],
"offsets": [
[
91,
98
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T9",
"type": "Procedure",
"text": [
"2D echocardiogram"
],
"offsets": [
[
153,
170
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T10",
"type": "Condition",
"text": [
"eripheral",
"enous congestion"
],
"offsets": [
[
189,
198
],
[
212,
228
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T11",
"type": "Condition",
"text": [
"central venous congestion"
],
"offsets": [
[
203,
228
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T12",
"type": "Condition",
"text": [
"lower extremity edema"
],
"offsets": [
[
243,
264
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T13",
"type": "Condition",
"text": [
"abdominal ascites"
],
"offsets": [
[
269,
286
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T14",
"type": "Drug",
"text": [
"diuretics"
],
"offsets": [
[
297,
306
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T15",
"type": "Scope",
"text": [
"peripheral and central venous congestion"
],
"offsets": [
[
188,
228
]
],
"normalized": []
},
{
"id": "NCT02339974_inc_T16",
"type": "Scope",
"text": [
"lower extremity edema and abdominal ascites requiring diuretics"
],
"offsets": [
[
243,
306
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02339974_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02339974_inc_T1",
"arg2_id": "NCT02339974_inc_T2",
"normalized": []
},
{
"id": "NCT02339974_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02339974_inc_T7",
"arg2_id": "NCT02339974_inc_T8",
"normalized": []
},
{
"id": "NCT02339974_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02339974_inc_T4",
"arg2_id": "NCT02339974_inc_T7",
"normalized": []
},
{
"id": "NCT02339974_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_inc_T5",
"arg2_id": "NCT02339974_inc_T4",
"normalized": []
},
{
"id": "NCT02339974_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02339974_inc_T5",
"arg2_id": "NCT02339974_inc_T3",
"normalized": []
},
{
"id": "NCT02339974_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02339974_inc_T5",
"arg2_id": "NCT02339974_inc_T6",
"normalized": []
},
{
"id": "NCT02339974_inc_R7",
"type": "AND",
"arg1_id": "NCT02339974_inc_T5",
"arg2_id": "NCT02339974_inc_T9",
"normalized": []
},
{
"id": "NCT02339974_inc_R10",
"type": "AND",
"arg1_id": "NCT02339974_inc_T13",
"arg2_id": "NCT02339974_inc_T14",
"normalized": []
},
{
"id": "NCT02339974_inc_R8",
"type": "Has_scope",
"arg1_id": "NCT02339974_inc_T9",
"arg2_id": "NCT02339974_inc_T15",
"normalized": []
},
{
"id": "NCT02339974_inc_R9",
"type": "Subsumes",
"arg1_id": "NCT02339974_inc_T15",
"arg2_id": "NCT02339974_inc_T16",
"normalized": []
}
] |
NCT02340169_exc | NCT02340169 | [
{
"id": "NCT02340169_exc_text",
"type": "exclusion",
"text": [
"Has other dermatological conditions that may interfere with clinical assessments\nAllergy or sensitivity to corticosteroids or any drug hypersensitivity or intolerance that would compromise patient safety or study results\nHistory of an adverse reaction to Cortrosyn™ or similar test reagents\nChronic infectious disease, system or organ disorder or other medical condition that would place patient at undue risk by study participation\n"
],
"offsets": [
[
0,
433
]
]
}
] | [
{
"id": "NCT02340169_exc_T2",
"type": "Qualifier",
"text": [
"corticosteroids"
],
"offsets": [
[
107,
122
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T3",
"type": "Condition",
"text": [
"drug hypersensitivity"
],
"offsets": [
[
130,
151
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T4",
"type": "Condition",
"text": [
"rug",
"ntolerance"
],
"offsets": [
[
131,
134
],
[
156,
166
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T5",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
81,
88
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T6",
"type": "Condition",
"text": [
"sensitivity"
],
"offsets": [
[
92,
103
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T8",
"type": "Drug",
"text": [
"corticosteroids"
],
"offsets": [
[
107,
122
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T9",
"type": "Scope",
"text": [
"Allergy or sensitivity"
],
"offsets": [
[
81,
103
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T10",
"type": "Scope",
"text": [
"drug hypersensitivity or intolerance"
],
"offsets": [
[
130,
166
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T11",
"type": "Condition",
"text": [
"adverse reaction"
],
"offsets": [
[
235,
251
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T12",
"type": "Qualifier",
"text": [
"Cortrosyn"
],
"offsets": [
[
255,
264
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T13",
"type": "Drug",
"text": [
"Cortrosyn"
],
"offsets": [
[
255,
264
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T14",
"type": "Procedure",
"text": [
"test reagents"
],
"offsets": [
[
277,
290
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T15",
"type": "Qualifier",
"text": [
"similar"
],
"offsets": [
[
269,
276
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T16",
"type": "Qualifier",
"text": [
"similar test reagents"
],
"offsets": [
[
269,
290
]
],
"normalized": []
},
{
"id": "NCT02340169_exc_T17",
"type": "Scope",
"text": [
"Cortrosyn™ or similar test reagents"
],
"offsets": [
[
255,
290
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02340169_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02340169_exc_T9",
"arg2_id": "NCT02340169_exc_T2",
"normalized": []
},
{
"id": "NCT02340169_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02340169_exc_T14",
"arg2_id": "NCT02340169_exc_T15",
"normalized": []
},
{
"id": "NCT02340169_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02340169_exc_T11",
"arg2_id": "NCT02340169_exc_T17",
"normalized": []
}
] |
NCT02340169_inc | NCT02340169 | [
{
"id": "NCT02340169_inc_text",
"type": "inclusion",
"text": [
"Patients aged 7 years and older must have provided written assent accompanied by written informed consent from patient's representative\nClinical diagnosis of stable plaque psoriasis with involvement of = 10% body surface area (excluding face and scalp)\nPhysicians Global Assessment score of 3 or 4 at baseline\n"
],
"offsets": [
[
0,
310
]
]
}
] | [
{
"id": "NCT02340169_inc_T1",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T2",
"type": "Value",
"text": [
"7 years and older"
],
"offsets": [
[
14,
31
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T4",
"type": "Condition",
"text": [
"plaque psoriasis"
],
"offsets": [
[
165,
181
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T5",
"type": "Qualifier",
"text": [
"stable"
],
"offsets": [
[
158,
164
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T6",
"type": "Measurement",
"text": [
"body surface area"
],
"offsets": [
[
208,
225
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T7",
"type": "Negation",
"text": [
"excluding"
],
"offsets": [
[
227,
236
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T8",
"type": "Condition",
"text": [
"face"
],
"offsets": [
[
237,
241
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T9",
"type": "Condition",
"text": [
"scalp"
],
"offsets": [
[
246,
251
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T10",
"type": "Value",
"text": [
"= 10%"
],
"offsets": [
[
202,
207
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T12",
"type": "Scope",
"text": [
"face and scalp"
],
"offsets": [
[
237,
251
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T13",
"type": "Measurement",
"text": [
"Physicians Global Assessment score"
],
"offsets": [
[
253,
287
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T14",
"type": "Value",
"text": [
"3"
],
"offsets": [
[
291,
292
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T15",
"type": "Value",
"text": [
"4"
],
"offsets": [
[
296,
297
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T16",
"type": "Temporal",
"text": [
"at baseline"
],
"offsets": [
[
298,
309
]
],
"normalized": []
},
{
"id": "NCT02340169_inc_T17",
"type": "Scope",
"text": [
"3 or 4"
],
"offsets": [
[
291,
297
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02340169_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02340169_inc_T1",
"arg2_id": "NCT02340169_inc_T2",
"normalized": []
},
{
"id": "NCT02340169_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02340169_inc_T4",
"arg2_id": "NCT02340169_inc_T5",
"normalized": []
},
{
"id": "NCT02340169_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02340169_inc_T6",
"arg2_id": "NCT02340169_inc_T10",
"normalized": []
},
{
"id": "NCT02340169_inc_R4",
"type": "AND",
"arg1_id": "NCT02340169_inc_T4",
"arg2_id": "NCT02340169_inc_T6",
"normalized": []
},
{
"id": "NCT02340169_inc_R5",
"type": "Has_negation",
"arg1_id": "NCT02340169_inc_T12",
"arg2_id": "NCT02340169_inc_T7",
"normalized": []
},
{
"id": "NCT02340169_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT02340169_inc_T4",
"arg2_id": "NCT02340169_inc_T12",
"normalized": []
},
{
"id": "NCT02340169_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02340169_inc_T13",
"arg2_id": "NCT02340169_inc_T17",
"normalized": []
},
{
"id": "NCT02340169_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02340169_inc_T13",
"arg2_id": "NCT02340169_inc_T16",
"normalized": []
}
] |
NCT02344888_exc | NCT02344888 | [
{
"id": "NCT02344888_exc_text",
"type": "exclusion",
"text": [
"Age < 20 or > 35 years.\nBody mass index (BMI) < 18.5 kg/m2 or > 25 kg/m2.\nPresence of any infertility factor other than anovulatory PCOS.\nPrevious history of ovarian surgery or surgical removal of one ovary.\nPrevious exposure to cytotoxic drugs or pelvic irradiation.\nOral hypoglycemic or hormonal therapy either currently or in the preceding 3 months.\nMetabolic or hormonal abnormalities\n"
],
"offsets": [
[
0,
389
]
]
}
] | [
{
"id": "NCT02344888_exc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T2",
"type": "Value",
"text": [
"< 20 or > 35 years"
],
"offsets": [
[
4,
22
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T3",
"type": "Measurement",
"text": [
"Body mass index"
],
"offsets": [
[
24,
39
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T4",
"type": "Measurement",
"text": [
"BMI"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T5",
"type": "Value",
"text": [
"< 18.5 kg/m2 or > 25 kg/m2"
],
"offsets": [
[
46,
72
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T6",
"type": "Condition",
"text": [
"infertility factor"
],
"offsets": [
[
90,
108
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T7",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
109,
119
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T8",
"type": "Condition",
"text": [
"anovulatory PCOS"
],
"offsets": [
[
120,
136
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T9",
"type": "Procedure",
"text": [
"ovarian surgery"
],
"offsets": [
[
158,
173
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T10",
"type": "Procedure",
"text": [
"surgical removal"
],
"offsets": [
[
177,
193
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T11",
"type": "Qualifier",
"text": [
"ovary"
],
"offsets": [
[
201,
206
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T12",
"type": "Multiplier",
"text": [
"one"
],
"offsets": [
[
197,
200
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T13",
"type": "Condition",
"text": [
"exposure"
],
"offsets": [
[
217,
225
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T14",
"type": "Drug",
"text": [
"cytotoxic drugs"
],
"offsets": [
[
229,
244
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T15",
"type": "Procedure",
"text": [
"pelvic irradiation"
],
"offsets": [
[
248,
266
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T16",
"type": "Scope",
"text": [
"cytotoxic drugs or pelvic irradiation"
],
"offsets": [
[
229,
266
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T17",
"type": "Procedure",
"text": [
"hormonal therapy"
],
"offsets": [
[
289,
305
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T18",
"type": "Procedure",
"text": [
"lycemic or h",
"py eith"
],
"offsets": [
[
278,
290
],
[
303,
310
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T19",
"type": "Qualifier",
"text": [
"Oral"
],
"offsets": [
[
268,
272
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T20",
"type": "Scope",
"text": [
"hypoglycemic or hormonal therapy"
],
"offsets": [
[
273,
305
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T21",
"type": "Temporal",
"text": [
"preceding 3 months"
],
"offsets": [
[
333,
351
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T22",
"type": "Condition",
"text": [
"hormonal abnormalities"
],
"offsets": [
[
366,
388
]
],
"normalized": []
},
{
"id": "NCT02344888_exc_T23",
"type": "Condition",
"text": [
"lic or ho",
"alities"
],
"offsets": [
[
359,
368
],
[
381,
388
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02344888_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02344888_exc_T1",
"arg2_id": "NCT02344888_exc_T2",
"normalized": []
},
{
"id": "NCT02344888_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02344888_exc_T3",
"arg2_id": "NCT02344888_exc_T4",
"normalized": []
},
{
"id": "NCT02344888_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02344888_exc_T3",
"arg2_id": "NCT02344888_exc_T5",
"normalized": []
},
{
"id": "NCT02344888_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02344888_exc_T8",
"arg2_id": "NCT02344888_exc_T7",
"normalized": []
},
{
"id": "NCT02344888_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02344888_exc_T10",
"arg2_id": "NCT02344888_exc_T11",
"normalized": []
},
{
"id": "NCT02344888_exc_R6",
"type": "Has_multiplier",
"arg1_id": "NCT02344888_exc_T11",
"arg2_id": "NCT02344888_exc_T12",
"normalized": []
},
{
"id": "NCT02344888_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT02344888_exc_T13",
"arg2_id": "NCT02344888_exc_T16",
"normalized": []
},
{
"id": "NCT02344888_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02344888_exc_T20",
"arg2_id": "NCT02344888_exc_T19",
"normalized": []
},
{
"id": "NCT02344888_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02344888_exc_T20",
"arg2_id": "NCT02344888_exc_T21",
"normalized": []
}
] |
NCT02344888_inc | NCT02344888 | [
{
"id": "NCT02344888_inc_text",
"type": "inclusion",
"text": [
"Infertile lean women with PCOS as defined by the Rotterdam criteria.\nCC resistance (defined as failure of ovulation after receiving 150 mg/day of CC for 5 consecutive days per cycle, for at least 3 consecutive cycles).\n"
],
"offsets": [
[
0,
219
]
]
}
] | [
{
"id": "NCT02344888_inc_T1",
"type": "Condition",
"text": [
"Infertile"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02344888_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
15,
20
]
],
"normalized": []
},
{
"id": "NCT02344888_inc_T3",
"type": "Condition",
"text": [
"PCOS"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "NCT02344888_inc_T4",
"type": "Qualifier",
"text": [
"Rotterdam criteria"
],
"offsets": [
[
49,
67
]
],
"normalized": []
},
{
"id": "NCT02344888_inc_T5",
"type": "Condition",
"text": [
"resistance"
],
"offsets": [
[
72,
82
]
],
"normalized": []
},
{
"id": "NCT02344888_inc_T6",
"type": "Drug",
"text": [
"CC"
],
"offsets": [
[
69,
71
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02344888_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02344888_inc_T1",
"arg2_id": "NCT02344888_inc_T4",
"normalized": []
},
{
"id": "NCT02344888_inc_R2",
"type": "AND",
"arg1_id": "NCT02344888_inc_T1",
"arg2_id": "NCT02344888_inc_T3",
"normalized": []
},
{
"id": "NCT02344888_inc_R3",
"type": "AND",
"arg1_id": "NCT02344888_inc_T5",
"arg2_id": "NCT02344888_inc_T6",
"normalized": []
}
] |
NCT02348918_exc | NCT02348918 | [
{
"id": "NCT02348918_exc_text",
"type": "exclusion",
"text": [
"Active proliferative diabetic retinopathy (PDR) in the study eye such as NVE, NVD, vitreous hemorrhage, or neovascular glaucoma.\nUncontrolled hypertension defined as systolic >180 mmHg or > 160 mmHg on 2 consecutive measurements or diastolic > 100 mmHg on optimal medical regimen\nScreening HgA1c blood test > 10.0\nFocal laser photocoagulation or intravitreal/periocular steroids of any type in the study eye within the last 90 days prior to study enrollment.\nA history of intravitreal anti-VEGF injection of any type in the study eye within the last 45 days prior to study enrollment.\nHistory of rhegmatogenous retinal detachment, retinal tear(s), or traction retinal detachments in the study eye.\nEpiretinal membrane and/or vitreomacular traction in the study eye as determined by the central reading center.\nPrevious pars plana vitrectomy in the study eye\nAny intraocular surgery in the study eye within the last 90 days prior to study enrollment.\nYAG laser treatment in the study eye in last 30 days prior to study enrollment.\nHigh myopia in the study eye, with a spherical equivalent of >8.00D at screening\nOther ocular pathologies that in the investigator's opinion would interfere with the subject's vision in the study eye.\nChronic or recurrent uveitis.\nOngoing ocular infection or inflammation in either eye.\nA history of cataract surgery complications/vitreous loss in the study eye.\nCongenital eye malformations in the study eye.\nA history of penetrating ocular trauma in the study eye.\nMentally handicapped.\nPregnant female, as determined for women less than 60 years old by a positive urine pregnancy test during the screening window.\nNursing female.\nCurrently participating in any other clinical research study.\nContraindication to the study medication.\n"
],
"offsets": [
[
0,
1767
]
]
}
] | [
{
"id": "NCT02348918_exc_T1",
"type": "Condition",
"text": [
"Active proliferative diabetic retinopathy (PDR)"
],
"offsets": [
[
0,
47
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T2",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
48,
64
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T3",
"type": "Condition",
"text": [
"NVE"
],
"offsets": [
[
73,
76
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T4",
"type": "Condition",
"text": [
"NVD"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T5",
"type": "Condition",
"text": [
"vitreous hemorrhage"
],
"offsets": [
[
83,
102
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T6",
"type": "Condition",
"text": [
"neovascular glaucoma"
],
"offsets": [
[
107,
127
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T7",
"type": "Scope",
"text": [
"NVE, NVD, vitreous hemorrhage, or neovascular glaucoma"
],
"offsets": [
[
73,
127
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T8",
"type": "Condition",
"text": [
"Uncontrolled hypertension"
],
"offsets": [
[
129,
154
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T9",
"type": "Measurement",
"text": [
"systolic"
],
"offsets": [
[
166,
174
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T10",
"type": "Value",
"text": [
">180 mmHg"
],
"offsets": [
[
175,
184
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T11",
"type": "Value",
"text": [
"> 160 mmHg"
],
"offsets": [
[
188,
198
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T12",
"type": "Multiplier",
"text": [
"on 2 consecutive measurements"
],
"offsets": [
[
199,
228
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T13",
"type": "Scope",
"text": [
">180 mmHg or > 160 mmHg on 2 consecutive measurements"
],
"offsets": [
[
175,
228
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T14",
"type": "Measurement",
"text": [
"diastolic"
],
"offsets": [
[
232,
241
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T15",
"type": "Value",
"text": [
"> 100 mmHg"
],
"offsets": [
[
242,
252
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T16",
"type": "Procedure",
"text": [
"optimal medical regimen"
],
"offsets": [
[
256,
279
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T17",
"type": "Qualifier",
"text": [
"on optimal medical regimen"
],
"offsets": [
[
253,
279
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T18",
"type": "Scope",
"text": [
"systolic >180 mmHg or > 160 mmHg on 2 consecutive measurements or diastolic > 100 mmHg on optimal medical regimen"
],
"offsets": [
[
166,
279
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T19",
"type": "Temporal",
"text": [
"Screening"
],
"offsets": [
[
280,
289
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T20",
"type": "Measurement",
"text": [
"HgA1c blood test"
],
"offsets": [
[
290,
306
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T21",
"type": "Value",
"text": [
"> 10.0"
],
"offsets": [
[
307,
313
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T22",
"type": "Procedure",
"text": [
"Focal laser photocoagulation"
],
"offsets": [
[
314,
342
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T23",
"type": "Drug",
"text": [
"intravitreal/periocular steroids"
],
"offsets": [
[
346,
378
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T24",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
391,
407
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T25",
"type": "Temporal",
"text": [
"within the last 90 days prior to study enrollment"
],
"offsets": [
[
408,
457
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T26",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
441,
457
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T27",
"type": "Scope",
"text": [
"Focal laser photocoagulation or intravitreal/periocular steroids"
],
"offsets": [
[
314,
378
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T28",
"type": "Observation",
"text": [
"history of"
],
"offsets": [
[
461,
471
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T29",
"type": "Qualifier",
"text": [
"intravitreal"
],
"offsets": [
[
472,
484
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T30",
"type": "Procedure",
"text": [
"anti-VEGF injection"
],
"offsets": [
[
485,
504
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T31",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
517,
533
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T32",
"type": "Temporal",
"text": [
"within the last 45 days prior to study enrollment"
],
"offsets": [
[
534,
583
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T33",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
567,
583
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T34",
"type": "Condition",
"text": [
"rhegmatogenous retinal detachment"
],
"offsets": [
[
596,
629
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T35",
"type": "Observation",
"text": [
"History of"
],
"offsets": [
[
585,
595
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T36",
"type": "Condition",
"text": [
"retinal tear(s)"
],
"offsets": [
[
631,
646
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T37",
"type": "Condition",
"text": [
"traction retinal detachments"
],
"offsets": [
[
651,
679
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T38",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
680,
696
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T39",
"type": "Scope",
"text": [
"rhegmatogenous retinal detachment, retinal tear(s), or traction retinal detachments"
],
"offsets": [
[
596,
679
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T40",
"type": "Condition",
"text": [
"Epiretinal membrane",
"traction"
],
"offsets": [
[
698,
717
],
[
739,
747
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T41",
"type": "Condition",
"text": [
"vitreomacular traction"
],
"offsets": [
[
725,
747
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T42",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
748,
764
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T44",
"type": "Scope",
"text": [
"Epiretinal membrane and/or vitreomacular traction"
],
"offsets": [
[
698,
747
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T45",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
810,
818
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T46",
"type": "Procedure",
"text": [
"pars plana vitrectomy"
],
"offsets": [
[
819,
840
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T47",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
841,
857
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T48",
"type": "Procedure",
"text": [
"intraocular surgery"
],
"offsets": [
[
862,
881
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T49",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
882,
898
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T50",
"type": "Temporal",
"text": [
"within the last 90 days prior to study enrollment"
],
"offsets": [
[
899,
948
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T51",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
932,
948
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T52",
"type": "Procedure",
"text": [
"YAG laser treatment"
],
"offsets": [
[
950,
969
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T53",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
970,
986
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T54",
"type": "Temporal",
"text": [
"in last 30 days prior to study enrollment"
],
"offsets": [
[
987,
1028
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T55",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
1012,
1028
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T56",
"type": "Condition",
"text": [
"High myopia"
],
"offsets": [
[
1030,
1041
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T57",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
1042,
1058
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T58",
"type": "Measurement",
"text": [
"spherical equivalent"
],
"offsets": [
[
1067,
1087
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T59",
"type": "Value",
"text": [
">8.00D"
],
"offsets": [
[
1091,
1097
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T60",
"type": "Temporal",
"text": [
"at screening"
],
"offsets": [
[
1098,
1110
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T61",
"type": "Qualifier",
"text": [
"Other"
],
"offsets": [
[
1111,
1116
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T62",
"type": "Condition",
"text": [
"ocular pathologies"
],
"offsets": [
[
1117,
1135
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T63",
"type": "Observation",
"text": [
"would interfere with the subject's vision in the study eye"
],
"offsets": [
[
1171,
1229
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T65",
"type": "Multiplier",
"text": [
"Chronic"
],
"offsets": [
[
1231,
1238
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T66",
"type": "Multiplier",
"text": [
"recurrent"
],
"offsets": [
[
1242,
1251
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T67",
"type": "Condition",
"text": [
"uveitis"
],
"offsets": [
[
1252,
1259
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T68",
"type": "Scope",
"text": [
"Chronic or recurrent"
],
"offsets": [
[
1231,
1251
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T69",
"type": "Temporal",
"text": [
"Ongoing"
],
"offsets": [
[
1261,
1268
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T70",
"type": "Condition",
"text": [
"ocular infection"
],
"offsets": [
[
1269,
1285
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T71",
"type": "Condition",
"text": [
"ocular",
"inflammation"
],
"offsets": [
[
1269,
1275
],
[
1289,
1301
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T72",
"type": "Qualifier",
"text": [
"in either eye"
],
"offsets": [
[
1302,
1315
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T73",
"type": "Scope",
"text": [
"ocular infection or inflammation"
],
"offsets": [
[
1269,
1301
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T74",
"type": "Observation",
"text": [
"history of"
],
"offsets": [
[
1319,
1329
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T75",
"type": "Procedure",
"text": [
"cataract surgery"
],
"offsets": [
[
1330,
1346
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T76",
"type": "Condition",
"text": [
"cataract surgery complications"
],
"offsets": [
[
1330,
1360
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T77",
"type": "Condition",
"text": [
"vitreous loss"
],
"offsets": [
[
1361,
1374
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T78",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
1375,
1391
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T79",
"type": "Scope",
"text": [
"cataract surgery complications/vitreous loss"
],
"offsets": [
[
1330,
1374
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T80",
"type": "Condition",
"text": [
"Congenital eye malformations"
],
"offsets": [
[
1393,
1421
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T81",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
1422,
1438
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T82",
"type": "Observation",
"text": [
"history of"
],
"offsets": [
[
1442,
1452
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T83",
"type": "Condition",
"text": [
"penetrating ocular trauma"
],
"offsets": [
[
1453,
1478
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T84",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
1479,
1495
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T85",
"type": "Condition",
"text": [
"Mentally handicapped"
],
"offsets": [
[
1497,
1517
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T86",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
1519,
1527
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T87",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
1528,
1534
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T88",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
1554,
1559
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T89",
"type": "Value",
"text": [
"less than 60 years"
],
"offsets": [
[
1560,
1578
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T90",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
1579,
1582
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T91",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
1588,
1596
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T92",
"type": "Measurement",
"text": [
"urine pregnancy test"
],
"offsets": [
[
1597,
1617
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T93",
"type": "Temporal",
"text": [
"during the screening window"
],
"offsets": [
[
1618,
1645
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T94",
"type": "Observation",
"text": [
"Nursing"
],
"offsets": [
[
1647,
1654
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T95",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
1655,
1661
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T97",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
1725,
1741
]
],
"normalized": []
},
{
"id": "NCT02348918_exc_T98",
"type": "Drug",
"text": [
"study medication"
],
"offsets": [
[
1749,
1765
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02348918_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T1",
"arg2_id": "NCT02348918_exc_T2",
"normalized": []
},
{
"id": "NCT02348918_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02348918_exc_T1",
"arg2_id": "NCT02348918_exc_T7",
"normalized": []
},
{
"id": "NCT02348918_exc_R3",
"type": "Has_multiplier",
"arg1_id": "NCT02348918_exc_T11",
"arg2_id": "NCT02348918_exc_T12",
"normalized": []
},
{
"id": "NCT02348918_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02348918_exc_T9",
"arg2_id": "NCT02348918_exc_T13",
"normalized": []
},
{
"id": "NCT02348918_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02348918_exc_T14",
"arg2_id": "NCT02348918_exc_T15",
"normalized": []
},
{
"id": "NCT02348918_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T14",
"arg2_id": "NCT02348918_exc_T17",
"normalized": []
},
{
"id": "NCT02348918_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT02348918_exc_T8",
"arg2_id": "NCT02348918_exc_T18",
"normalized": []
},
{
"id": "NCT02348918_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02348918_exc_T20",
"arg2_id": "NCT02348918_exc_T21",
"normalized": []
},
{
"id": "NCT02348918_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T20",
"arg2_id": "NCT02348918_exc_T19",
"normalized": []
},
{
"id": "NCT02348918_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02348918_exc_T25",
"arg2_id": "NCT02348918_exc_T26",
"normalized": []
},
{
"id": "NCT02348918_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T27",
"arg2_id": "NCT02348918_exc_T24",
"normalized": []
},
{
"id": "NCT02348918_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T27",
"arg2_id": "NCT02348918_exc_T25",
"normalized": []
},
{
"id": "NCT02348918_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T30",
"arg2_id": "NCT02348918_exc_T29",
"normalized": []
},
{
"id": "NCT02348918_exc_R15",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T30",
"arg2_id": "NCT02348918_exc_T28",
"normalized": []
},
{
"id": "NCT02348918_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T30",
"arg2_id": "NCT02348918_exc_T31",
"normalized": []
},
{
"id": "NCT02348918_exc_R17",
"type": "Has_index",
"arg1_id": "NCT02348918_exc_T32",
"arg2_id": "NCT02348918_exc_T33",
"normalized": []
},
{
"id": "NCT02348918_exc_R18",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T30",
"arg2_id": "NCT02348918_exc_T32",
"normalized": []
},
{
"id": "NCT02348918_exc_R19",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T39",
"arg2_id": "NCT02348918_exc_T35",
"normalized": []
},
{
"id": "NCT02348918_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T39",
"arg2_id": "NCT02348918_exc_T38",
"normalized": []
},
{
"id": "NCT02348918_exc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T44",
"arg2_id": "NCT02348918_exc_T42",
"normalized": []
},
{
"id": "NCT02348918_exc_R22",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T46",
"arg2_id": "NCT02348918_exc_T47",
"normalized": []
},
{
"id": "NCT02348918_exc_R23",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T46",
"arg2_id": "NCT02348918_exc_T45",
"normalized": []
},
{
"id": "NCT02348918_exc_R24",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T48",
"arg2_id": "NCT02348918_exc_T49",
"normalized": []
},
{
"id": "NCT02348918_exc_R25",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T48",
"arg2_id": "NCT02348918_exc_T50",
"normalized": []
},
{
"id": "NCT02348918_exc_R26",
"type": "Has_index",
"arg1_id": "NCT02348918_exc_T50",
"arg2_id": "NCT02348918_exc_T51",
"normalized": []
},
{
"id": "NCT02348918_exc_R27",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T52",
"arg2_id": "NCT02348918_exc_T53",
"normalized": []
},
{
"id": "NCT02348918_exc_R28",
"type": "Has_index",
"arg1_id": "NCT02348918_exc_T54",
"arg2_id": "NCT02348918_exc_T55",
"normalized": []
},
{
"id": "NCT02348918_exc_R29",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T52",
"arg2_id": "NCT02348918_exc_T54",
"normalized": []
},
{
"id": "NCT02348918_exc_R30",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T56",
"arg2_id": "NCT02348918_exc_T57",
"normalized": []
},
{
"id": "NCT02348918_exc_R31",
"type": "Has_value",
"arg1_id": "NCT02348918_exc_T58",
"arg2_id": "NCT02348918_exc_T59",
"normalized": []
},
{
"id": "NCT02348918_exc_R32",
"type": "AND",
"arg1_id": "NCT02348918_exc_T56",
"arg2_id": "NCT02348918_exc_T58",
"normalized": []
},
{
"id": "NCT02348918_exc_R33",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T56",
"arg2_id": "NCT02348918_exc_T60",
"normalized": []
},
{
"id": "NCT02348918_exc_R35",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T62",
"arg2_id": "NCT02348918_exc_T61",
"normalized": []
},
{
"id": "NCT02348918_exc_R36",
"type": "Has_scope",
"arg1_id": "NCT02348918_exc_T67",
"arg2_id": "NCT02348918_exc_T68",
"normalized": []
},
{
"id": "NCT02348918_exc_R38",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T79",
"arg2_id": "NCT02348918_exc_T74",
"normalized": []
},
{
"id": "NCT02348918_exc_R39",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T79",
"arg2_id": "NCT02348918_exc_T78",
"normalized": []
},
{
"id": "NCT02348918_exc_R40",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T80",
"arg2_id": "NCT02348918_exc_T81",
"normalized": []
},
{
"id": "NCT02348918_exc_R41",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_exc_T83",
"arg2_id": "NCT02348918_exc_T84",
"normalized": []
},
{
"id": "NCT02348918_exc_R42",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T83",
"arg2_id": "NCT02348918_exc_T82",
"normalized": []
},
{
"id": "NCT02348918_exc_R43",
"type": "Has_value",
"arg1_id": "NCT02348918_exc_T90",
"arg2_id": "NCT02348918_exc_T89",
"normalized": []
},
{
"id": "NCT02348918_exc_R44",
"type": "Has_temporal",
"arg1_id": "NCT02348918_exc_T92",
"arg2_id": "NCT02348918_exc_T93",
"normalized": []
},
{
"id": "NCT02348918_exc_R45",
"type": "Has_value",
"arg1_id": "NCT02348918_exc_T92",
"arg2_id": "NCT02348918_exc_T91",
"normalized": []
},
{
"id": "NCT02348918_exc_R46",
"type": "AND",
"arg1_id": "NCT02348918_exc_T97",
"arg2_id": "NCT02348918_exc_T98",
"normalized": []
}
] |
NCT02348918_inc | NCT02348918 | [
{
"id": "NCT02348918_inc_text",
"type": "inclusion",
"text": [
"Male or female, 18 years of age or older.\nStudy eye with clinically significant diabetic macular edema (DME) with central subfield thickness ≥ 350µm on spectral domain OCT\nBest corrected visual acuity (BCVA) of 20/50 to 20/320 ETDRS equivalent (65 letters to 23 letters) in the study eye, with BCVA decrement primarily attributable to DME.\nTreatment naïve, i.e., no previous anti-VEGF treatment in the study eye or no anti-VEGF treatment in the 45 days prior to study enrollment.\nIn the investigator's opinion, the subject still has significant intraretinal fluid with room for improvement in both macular edema and BCVA.\nIntra-Ocular Pressure (IOP) is under control (i.e., IOP ≤ 25 mm in the study eye) and study eye is not receiving any IOP lowering drops.\nWilling and able to return for all study visits.\nAble to meet the extensive post-op evaluation regimen.\nUnderstands and signs the informed consent form.\n"
],
"offsets": [
[
0,
912
]
]
}
] | [
{
"id": "NCT02348918_inc_T1",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T3",
"type": "Value",
"text": [
"18 years",
"or older"
],
"offsets": [
[
16,
24
],
[
32,
40
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
28,
31
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T5",
"type": "Condition",
"text": [
"diabetic macular edema (DME)"
],
"offsets": [
[
80,
108
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T6",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
57,
79
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T7",
"type": "Measurement",
"text": [
"central subfield thickness"
],
"offsets": [
[
114,
140
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T8",
"type": "Value",
"text": [
"≥ 350µm"
],
"offsets": [
[
141,
148
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T9",
"type": "Procedure",
"text": [
"spectral domain OCT"
],
"offsets": [
[
152,
171
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T10",
"type": "Measurement",
"text": [
"Best corrected visual acuity (BCVA)"
],
"offsets": [
[
172,
207
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T11",
"type": "Value",
"text": [
"20/50 to 20/320 ETDRS equivalent"
],
"offsets": [
[
211,
243
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T12",
"type": "Value",
"text": [
"65 letters to 23 letters"
],
"offsets": [
[
245,
269
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T13",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
271,
287
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T15",
"type": "Observation",
"text": [
"Treatment naïve"
],
"offsets": [
[
340,
355
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T16",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
363,
365
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T17",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
366,
374
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T18",
"type": "Procedure",
"text": [
"anti-VEGF treatment"
],
"offsets": [
[
375,
394
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T19",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
395,
411
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T20",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
415,
417
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T21",
"type": "Procedure",
"text": [
"anti-VEGF treatment"
],
"offsets": [
[
418,
437
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T22",
"type": "Temporal",
"text": [
"in the 45 days prior to study enrollment"
],
"offsets": [
[
438,
478
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T23",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
462,
478
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T24",
"type": "Scope",
"text": [
"no previous anti-VEGF treatment in the study eye or no anti-VEGF treatment in the 45 days prior to study enrollment"
],
"offsets": [
[
363,
478
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T26",
"type": "Qualifier",
"text": [
"significant"
],
"offsets": [
[
533,
544
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T27",
"type": "Condition",
"text": [
"intraretinal fluid"
],
"offsets": [
[
545,
563
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T28",
"type": "Qualifier",
"text": [
"with room for improvement"
],
"offsets": [
[
564,
589
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T30",
"type": "Condition",
"text": [
"macular edema"
],
"offsets": [
[
598,
611
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T31",
"type": "Condition",
"text": [
"BCVA"
],
"offsets": [
[
616,
620
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T32",
"type": "Scope",
"text": [
"macular edema and BCVA"
],
"offsets": [
[
598,
620
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T33",
"type": "Measurement",
"text": [
"Intra-Ocular Pressure (IOP)"
],
"offsets": [
[
622,
649
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T34",
"type": "Value",
"text": [
"under control"
],
"offsets": [
[
653,
666
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T35",
"type": "Measurement",
"text": [
"IOP"
],
"offsets": [
[
674,
677
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T36",
"type": "Value",
"text": [
"≤ 25 mm"
],
"offsets": [
[
678,
685
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T37",
"type": "Qualifier",
"text": [
"in the study eye"
],
"offsets": [
[
686,
702
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T38",
"type": "Drug",
"text": [
"IOP lowering drops"
],
"offsets": [
[
739,
757
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T39",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
721,
724
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T40",
"type": "Qualifier",
"text": [
"study eye"
],
"offsets": [
[
708,
717
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T41",
"type": "Scope",
"text": [
"IOP ≤ 25 mm in the study eye"
],
"offsets": [
[
674,
702
]
],
"normalized": []
},
{
"id": "NCT02348918_inc_T42",
"type": "Scope",
"text": [
"Intra-Ocular Pressure (IOP) is under control"
],
"offsets": [
[
622,
666
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02348918_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02348918_inc_T4",
"arg2_id": "NCT02348918_inc_T3",
"normalized": []
},
{
"id": "NCT02348918_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T5",
"arg2_id": "NCT02348918_inc_T6",
"normalized": []
},
{
"id": "NCT02348918_inc_R3",
"type": "AND",
"arg1_id": "NCT02348918_inc_T9",
"arg2_id": "NCT02348918_inc_T7",
"normalized": []
},
{
"id": "NCT02348918_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02348918_inc_T7",
"arg2_id": "NCT02348918_inc_T8",
"normalized": []
},
{
"id": "NCT02348918_inc_R5",
"type": "AND",
"arg1_id": "NCT02348918_inc_T5",
"arg2_id": "NCT02348918_inc_T9",
"normalized": []
},
{
"id": "NCT02348918_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02348918_inc_T11",
"arg2_id": "NCT02348918_inc_T12",
"normalized": []
},
{
"id": "NCT02348918_inc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T10",
"arg2_id": "NCT02348918_inc_T13",
"normalized": []
},
{
"id": "NCT02348918_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02348918_inc_T10",
"arg2_id": "NCT02348918_inc_T11",
"normalized": []
},
{
"id": "NCT02348918_inc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T18",
"arg2_id": "NCT02348918_inc_T19",
"normalized": []
},
{
"id": "NCT02348918_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02348918_inc_T18",
"arg2_id": "NCT02348918_inc_T17",
"normalized": []
},
{
"id": "NCT02348918_inc_R11",
"type": "Has_negation",
"arg1_id": "NCT02348918_inc_T18",
"arg2_id": "NCT02348918_inc_T16",
"normalized": []
},
{
"id": "NCT02348918_inc_R12",
"type": "Has_index",
"arg1_id": "NCT02348918_inc_T22",
"arg2_id": "NCT02348918_inc_T23",
"normalized": []
},
{
"id": "NCT02348918_inc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02348918_inc_T21",
"arg2_id": "NCT02348918_inc_T22",
"normalized": []
},
{
"id": "NCT02348918_inc_R14",
"type": "Has_negation",
"arg1_id": "NCT02348918_inc_T21",
"arg2_id": "NCT02348918_inc_T20",
"normalized": []
},
{
"id": "NCT02348918_inc_R15",
"type": "Subsumes",
"arg1_id": "NCT02348918_inc_T15",
"arg2_id": "NCT02348918_inc_T24",
"normalized": []
},
{
"id": "NCT02348918_inc_R17",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T27",
"arg2_id": "NCT02348918_inc_T26",
"normalized": []
},
{
"id": "NCT02348918_inc_R16",
"type": "Has_scope",
"arg1_id": "NCT02348918_inc_T28",
"arg2_id": "NCT02348918_inc_T32",
"normalized": []
},
{
"id": "NCT02348918_inc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T27",
"arg2_id": "NCT02348918_inc_T28",
"normalized": []
},
{
"id": "NCT02348918_inc_R20",
"type": "Has_value",
"arg1_id": "NCT02348918_inc_T35",
"arg2_id": "NCT02348918_inc_T36",
"normalized": []
},
{
"id": "NCT02348918_inc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T35",
"arg2_id": "NCT02348918_inc_T37",
"normalized": []
},
{
"id": "NCT02348918_inc_R22",
"type": "Has_value",
"arg1_id": "NCT02348918_inc_T33",
"arg2_id": "NCT02348918_inc_T34",
"normalized": []
},
{
"id": "NCT02348918_inc_R23",
"type": "Has_negation",
"arg1_id": "NCT02348918_inc_T38",
"arg2_id": "NCT02348918_inc_T39",
"normalized": []
},
{
"id": "NCT02348918_inc_R24",
"type": "Has_qualifier",
"arg1_id": "NCT02348918_inc_T38",
"arg2_id": "NCT02348918_inc_T40",
"normalized": []
},
{
"id": "NCT02348918_inc_R25",
"type": "Has_scope",
"arg1_id": "NCT02348918_inc_T42",
"arg2_id": "NCT02348918_inc_T41",
"normalized": []
}
] |
NCT02350439_exc | NCT02350439 | [
{
"id": "NCT02350439_exc_text",
"type": "exclusion",
"text": [
"1. Left main disease (angiographically> 50%) \n2. Cardiogenic shock / hemodynamic instability \n3. Previous CABG \n4. Increased risk of bradycardia on investigator clinical judgment \n5. Severe chronic obstructive pulmonary disease \n6. Coronary vessels with tortuosity or extremely calcified \n7. Severe left ventricular hypertrophy or severe valvular disease \n8. STEMI or non-STEMI within the past five days \n9. Previous myocardial infarction in the distribution of the target vessel for the FFR \n10. Acute decompensated heart failure. \n \n"
],
"offsets": [
[
0,
544
]
]
}
] | [
{
"id": "NCT02350439_exc_T11",
"type": "Condition",
"text": [
"Left main disease"
],
"offsets": [
[
3,
20
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T12",
"type": "Value",
"text": [
"> 50%"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T14",
"type": "Condition",
"text": [
"Cardiogenic shock"
],
"offsets": [
[
49,
66
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T15",
"type": "Condition",
"text": [
"hemodynamic instability"
],
"offsets": [
[
69,
92
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T16",
"type": "Condition",
"text": [
"CABG"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T17",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
97,
105
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T18",
"type": "Condition",
"text": [
"bradycardia"
],
"offsets": [
[
133,
144
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T22",
"type": "Qualifier",
"text": [
"Increased risk"
],
"offsets": [
[
115,
129
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T23",
"type": "Condition",
"text": [
"chronic obstructive pulmonary disease"
],
"offsets": [
[
190,
227
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T24",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
183,
189
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T25",
"type": "Condition",
"text": [
"Coronary vessel",
"tortuosity"
],
"offsets": [
[
232,
247
],
[
254,
264
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T26",
"type": "Condition",
"text": [
"Coronary vessel",
"extremely calcified"
],
"offsets": [
[
232,
247
],
[
268,
287
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T27",
"type": "Condition",
"text": [
"left ventricular hypertrophy"
],
"offsets": [
[
299,
327
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T28",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
292,
298
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T29",
"type": "Condition",
"text": [
"valvular disease"
],
"offsets": [
[
338,
354
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T30",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
331,
337
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T31",
"type": "Condition",
"text": [
"STEMI"
],
"offsets": [
[
359,
364
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T32",
"type": "Condition",
"text": [
"non-STEMI"
],
"offsets": [
[
368,
377
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T33",
"type": "Temporal",
"text": [
"within the past five days"
],
"offsets": [
[
378,
403
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T34",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
417,
438
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T35",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
408,
416
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T36",
"type": "Qualifier",
"text": [
"in the distribution of the target vessel"
],
"offsets": [
[
439,
479
]
],
"normalized": []
},
{
"id": "NCT02350439_exc_T37",
"type": "Condition",
"text": [
"Acute decompensated heart failure"
],
"offsets": [
[
497,
530
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02350439_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02350439_exc_T16",
"arg2_id": "NCT02350439_exc_T17",
"normalized": []
},
{
"id": "NCT02350439_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02350439_exc_T18",
"arg2_id": "NCT02350439_exc_T22",
"normalized": []
},
{
"id": "NCT02350439_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02350439_exc_T23",
"arg2_id": "NCT02350439_exc_T24",
"normalized": []
},
{
"id": "NCT02350439_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02350439_exc_T27",
"arg2_id": "NCT02350439_exc_T28",
"normalized": []
},
{
"id": "NCT02350439_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02350439_exc_T32",
"arg2_id": "NCT02350439_exc_T33",
"normalized": []
},
{
"id": "NCT02350439_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02350439_exc_T31",
"arg2_id": "NCT02350439_exc_T33",
"normalized": []
},
{
"id": "NCT02350439_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02350439_exc_T34",
"arg2_id": "NCT02350439_exc_T35",
"normalized": []
},
{
"id": "NCT02350439_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02350439_exc_T34",
"arg2_id": "NCT02350439_exc_T36",
"normalized": []
}
] |
NCT02350439_inc | NCT02350439 | [
{
"id": "NCT02350439_inc_text",
"type": "inclusion",
"text": [
"1. Age 18-80 years \n2. Patients with at least 1 ≥50% stenosis in a coronary vessel, subjected to FFR assessment, who exhibit variation in Pd / Pa ratio ≥ 0.05 (e.g. difference of max Pd/Pa minus min Pd/Pa) during steady state hyperaemia (determined by visual assessment). \n3. Written informed consent \n"
],
"offsets": [
[
0,
302
]
]
}
] | [
{
"id": "NCT02350439_inc_T4",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
3,
6
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T5",
"type": "Value",
"text": [
"18-80 years"
],
"offsets": [
[
7,
18
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T6",
"type": "Multiplier",
"text": [
"at least 1"
],
"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T7",
"type": "Value",
"text": [
"≥50%"
],
"offsets": [
[
48,
52
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T8",
"type": "Measurement",
"text": [
"stenosis in a coronary vessel"
],
"offsets": [
[
53,
82
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T9",
"type": "Procedure",
"text": [
"FFR assessment"
],
"offsets": [
[
97,
111
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T10",
"type": "Measurement",
"text": [
"Pd / Pa ratio"
],
"offsets": [
[
138,
151
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T11",
"type": "Value",
"text": [
"≥ 0.05"
],
"offsets": [
[
152,
158
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T12",
"type": "Measurement",
"text": [
"max Pd/Pa"
],
"offsets": [
[
179,
188
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T13",
"type": "Measurement",
"text": [
"min Pd/Pa"
],
"offsets": [
[
195,
204
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T14",
"type": "Condition",
"text": [
"hyperaemia"
],
"offsets": [
[
226,
236
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T15",
"type": "Qualifier",
"text": [
"steady state"
],
"offsets": [
[
213,
225
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T16",
"type": "Procedure",
"text": [
"visual assessment"
],
"offsets": [
[
252,
269
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T17",
"type": "Scope",
"text": [
"(e.g. difference of max Pd/Pa minus min Pd/Pa)"
],
"offsets": [
[
159,
205
]
],
"normalized": []
},
{
"id": "NCT02350439_inc_T18",
"type": "Condition",
"text": [
"variation in Pd / Pa ratio"
],
"offsets": [
[
125,
151
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02350439_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02350439_inc_T4",
"arg2_id": "NCT02350439_inc_T5",
"normalized": []
},
{
"id": "NCT02350439_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02350439_inc_T8",
"arg2_id": "NCT02350439_inc_T7",
"normalized": []
},
{
"id": "NCT02350439_inc_R3",
"type": "Has_multiplier",
"arg1_id": "NCT02350439_inc_T8",
"arg2_id": "NCT02350439_inc_T6",
"normalized": []
},
{
"id": "NCT02350439_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02350439_inc_T10",
"arg2_id": "NCT02350439_inc_T11",
"normalized": []
},
{
"id": "NCT02350439_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02350439_inc_T14",
"arg2_id": "NCT02350439_inc_T15",
"normalized": []
},
{
"id": "NCT02350439_inc_R6",
"type": "AND",
"arg1_id": "NCT02350439_inc_T14",
"arg2_id": "NCT02350439_inc_T16",
"normalized": []
},
{
"id": "NCT02350439_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02350439_inc_T18",
"arg2_id": "NCT02350439_inc_T17",
"normalized": []
}
] |
NCT02357654_exc | NCT02357654 | [
{
"id": "NCT02357654_exc_text",
"type": "exclusion",
"text": [
"day 3 transfers\n"
],
"offsets": [
[
0,
16
]
]
}
] | [] | [] | [] | [] |
NCT02357654_inc | NCT02357654 | [
{
"id": "NCT02357654_inc_text",
"type": "inclusion",
"text": [
"women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old.\n"
],
"offsets": [
[
0,
88
]
]
}
] | [
{
"id": "NCT02357654_inc_T1",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02357654_inc_T2",
"type": "Procedure",
"text": [
"IVF"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "NCT02357654_inc_T3",
"type": "Procedure",
"text": [
"ICSI"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "NCT02357654_inc_T4",
"type": "Procedure",
"text": [
"frozen embryo transfers (FET)"
],
"offsets": [
[
29,
58
]
],
"normalized": []
},
{
"id": "NCT02357654_inc_T5",
"type": "Value",
"text": [
"less than 40 years"
],
"offsets": [
[
64,
82
]
],
"normalized": []
},
{
"id": "NCT02357654_inc_T6",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
83,
86
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02357654_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02357654_inc_T6",
"arg2_id": "NCT02357654_inc_T5",
"normalized": []
}
] |
NCT02360631_exc | NCT02360631 | [
{
"id": "NCT02360631_exc_text",
"type": "exclusion",
"text": [
"Renal impairment\nEvidence or history of clinically significant allergic reactions to varenicline\nA cardiovascular event in the past month\nHistory of alcohol or drug dependence in the past year\nMajor depressive disorder in the last year requiring treatment\nHistory of panic disorder, psychosis, bipolar disorder, or eating disorders\nUse of tobacco products other than cigarettes in past 30 days\nUse of pharmacotherapy in the month prior to enrollment, including prior use of varenicline\nPregnant, contemplating getting pregnant, or breastfeeding\nPlans to move from Kansas City during the treatment and follow-up phase\nAnother household member enrolled in the study\nEvidence of current severe major depressive disorder or suicidal ideation\n"
],
"offsets": [
[
0,
738
]
]
}
] | [
{
"id": "NCT02360631_exc_T1",
"type": "Condition",
"text": [
"Renal impairment"
],
"offsets": [
[
0,
16
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T2",
"type": "Condition",
"text": [
"allergic"
],
"offsets": [
[
63,
71
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T3",
"type": "Drug",
"text": [
"varenicline"
],
"offsets": [
[
85,
96
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T4",
"type": "Condition",
"text": [
"cardiovascular event"
],
"offsets": [
[
99,
119
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T5",
"type": "Temporal",
"text": [
"in the past month"
],
"offsets": [
[
120,
137
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T6",
"type": "Condition",
"text": [
"drug dependence"
],
"offsets": [
[
160,
175
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T7",
"type": "Condition",
"text": [
"ohol or",
"endence in"
],
"offsets": [
[
152,
159
],
[
168,
178
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T8",
"type": "Scope",
"text": [
"alcohol or drug dependence"
],
"offsets": [
[
149,
175
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T9",
"type": "Temporal",
"text": [
"the past year"
],
"offsets": [
[
179,
192
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T10",
"type": "Condition",
"text": [
"Major depressive disorder"
],
"offsets": [
[
193,
218
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T11",
"type": "Temporal",
"text": [
"last year"
],
"offsets": [
[
226,
235
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T12",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
246,
255
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T13",
"type": "Condition",
"text": [
"panic disorder"
],
"offsets": [
[
267,
281
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T14",
"type": "Condition",
"text": [
"psychosis"
],
"offsets": [
[
283,
292
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T15",
"type": "Condition",
"text": [
"bipolar disorder"
],
"offsets": [
[
294,
310
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T16",
"type": "Condition",
"text": [
"eating disorders"
],
"offsets": [
[
315,
331
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T17",
"type": "Observation",
"text": [
"Use of tobacco"
],
"offsets": [
[
332,
346
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T18",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
356,
366
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T19",
"type": "Observation",
"text": [
"cigarettes"
],
"offsets": [
[
367,
377
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T20",
"type": "Temporal",
"text": [
"past 30 days"
],
"offsets": [
[
381,
393
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T21",
"type": "Procedure",
"text": [
"pharmacotherapy"
],
"offsets": [
[
401,
416
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T22",
"type": "Temporal",
"text": [
"month prior to enrollment"
],
"offsets": [
[
424,
449
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T23",
"type": "Reference_point",
"text": [
"enrollment"
],
"offsets": [
[
439,
449
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T27",
"type": "Condition",
"text": [
"major depressive disorder"
],
"offsets": [
[
691,
716
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T28",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
684,
690
]
],
"normalized": []
},
{
"id": "NCT02360631_exc_T29",
"type": "Condition",
"text": [
"suicidal ideation"
],
"offsets": [
[
720,
737
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02360631_exc_R1",
"type": "AND",
"arg1_id": "NCT02360631_exc_T2",
"arg2_id": "NCT02360631_exc_T3",
"normalized": []
},
{
"id": "NCT02360631_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02360631_exc_T4",
"arg2_id": "NCT02360631_exc_T5",
"normalized": []
},
{
"id": "NCT02360631_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02360631_exc_T8",
"arg2_id": "NCT02360631_exc_T9",
"normalized": []
},
{
"id": "NCT02360631_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02360631_exc_T10",
"arg2_id": "NCT02360631_exc_T11",
"normalized": []
},
{
"id": "NCT02360631_exc_R5",
"type": "AND",
"arg1_id": "NCT02360631_exc_T10",
"arg2_id": "NCT02360631_exc_T12",
"normalized": []
},
{
"id": "NCT02360631_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02360631_exc_T17",
"arg2_id": "NCT02360631_exc_T20",
"normalized": []
},
{
"id": "NCT02360631_exc_R8",
"type": "Has_index",
"arg1_id": "NCT02360631_exc_T22",
"arg2_id": "NCT02360631_exc_T23",
"normalized": []
},
{
"id": "NCT02360631_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02360631_exc_T21",
"arg2_id": "NCT02360631_exc_T22",
"normalized": []
},
{
"id": "NCT02360631_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02360631_exc_T27",
"arg2_id": "NCT02360631_exc_T28",
"normalized": []
}
] |
NCT02360631_inc | NCT02360631 | [
{
"id": "NCT02360631_inc_text",
"type": "inclusion",
"text": [
"Self-identified African American\nSmokes = 1 cigarette per day (cpd)\nSmoke on = 25 days of the past 30 days\nFunctioning telephone\nInterested in quitting smoking\nInterested in taking 3 months of varenicline\nWilling to complete all study visits\n"
],
"offsets": [
[
0,
242
]
]
}
] | [
{
"id": "NCT02360631_inc_T1",
"type": "Person",
"text": [
"African American"
],
"offsets": [
[
16,
32
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T2",
"type": "Observation",
"text": [
"Smokes"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T3",
"type": "Multiplier",
"text": [
"= 1 cigarette per day"
],
"offsets": [
[
40,
61
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T4",
"type": "Observation",
"text": [
"Smoke"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T5",
"type": "Multiplier",
"text": [
"= 25 days of the past 30 days"
],
"offsets": [
[
77,
106
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T7",
"type": "Mood",
"text": [
"Interested"
],
"offsets": [
[
129,
139
]
],
"normalized": []
},
{
"id": "NCT02360631_inc_T8",
"type": "Observation",
"text": [
"quitting smoking"
],
"offsets": [
[
143,
159
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02360631_inc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02360631_inc_T2",
"arg2_id": "NCT02360631_inc_T3",
"normalized": []
},
{
"id": "NCT02360631_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT02360631_inc_T4",
"arg2_id": "NCT02360631_inc_T5",
"normalized": []
},
{
"id": "NCT02360631_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT02360631_inc_T8",
"arg2_id": "NCT02360631_inc_T7",
"normalized": []
}
] |
NCT02361892_exc | NCT02361892 | [
{
"id": "NCT02361892_exc_text",
"type": "exclusion",
"text": [
"endometrial hyperplasia with atypia,\nestrogen-progestin therapy in the 2 months before enrollment,\nautoimmune diseases,\nchronic, metabolic, systemic and endocrine disorders, including hyperandrogenism, hyperprolactinemia, diabetes mellitus and thyroid disease,\nhypogonadotropic hypogonadism,\nmajors clinical conditions\n"
],
"offsets": [
[
0,
319
]
]
}
] | [
{
"id": "NCT02361892_exc_T1",
"type": "Condition",
"text": [
"endometrial hyperplasia"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T2",
"type": "Condition",
"text": [
"atypia"
],
"offsets": [
[
29,
35
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T3",
"type": "Procedure",
"text": [
"estrogen-progestin therapy"
],
"offsets": [
[
37,
63
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T4",
"type": "Temporal",
"text": [
"in the 2 months before enrollment"
],
"offsets": [
[
64,
97
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T5",
"type": "Condition",
"text": [
"autoimmune diseases"
],
"offsets": [
[
99,
118
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T6",
"type": "Condition",
"text": [
"onic, m",
"orders, i"
],
"offsets": [
[
123,
130
],
[
166,
175
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T7",
"type": "Condition",
"text": [
"abolic, s",
"orders, i"
],
"offsets": [
[
132,
141
],
[
166,
175
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T8",
"type": "Condition",
"text": [
"temic an",
"orders, i"
],
"offsets": [
[
143,
151
],
[
166,
175
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T9",
"type": "Condition",
"text": [
"endocrine disorders"
],
"offsets": [
[
153,
172
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T10",
"type": "Condition",
"text": [
"hyperandrogenism"
],
"offsets": [
[
184,
200
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T11",
"type": "Condition",
"text": [
"hyperprolactinemia"
],
"offsets": [
[
202,
220
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T12",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
222,
239
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T13",
"type": "Condition",
"text": [
"thyroid disease"
],
"offsets": [
[
244,
259
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T14",
"type": "Scope",
"text": [
"hyperandrogenism, hyperprolactinemia, diabetes mellitus and thyroid disease"
],
"offsets": [
[
184,
259
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T15",
"type": "Scope",
"text": [
"chronic, metabolic, systemic and endocrine disorders"
],
"offsets": [
[
120,
172
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T16",
"type": "Condition",
"text": [
"hypogonadotropic hypogonadism"
],
"offsets": [
[
261,
290
]
],
"normalized": []
},
{
"id": "NCT02361892_exc_T17",
"type": "Condition",
"text": [
"majors clinical conditions"
],
"offsets": [
[
292,
318
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02361892_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02361892_exc_T15",
"arg2_id": "NCT02361892_exc_T14",
"normalized": []
}
] |
NCT02361892_inc | NCT02361892 | [
{
"id": "NCT02361892_inc_text",
"type": "inclusion",
"text": [
"submucosal,\nintramural or subserosal leiomyomas,\nsymptoms of menometrorrhagia,\nmenstrual disorder,\ninfertility,\npelvic pain\n"
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "NCT02361892_inc_T1",
"type": "Condition",
"text": [
"submucosal"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T2",
"type": "Condition",
"text": [
"subserosal leiomyomas"
],
"offsets": [
[
26,
47
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T3",
"type": "Condition",
"text": [
"ntramural",
"eiomyomas,"
],
"offsets": [
[
13,
22
],
[
38,
48
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T4",
"type": "Mood",
"text": [
"symptoms"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T5",
"type": "Condition",
"text": [
"menometrorrhagia"
],
"offsets": [
[
61,
77
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T6",
"type": "Condition",
"text": [
"menstrual disorder"
],
"offsets": [
[
79,
97
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T7",
"type": "Condition",
"text": [
"infertility"
],
"offsets": [
[
99,
110
]
],
"normalized": []
},
{
"id": "NCT02361892_inc_T8",
"type": "Condition",
"text": [
"pelvic pain"
],
"offsets": [
[
112,
123
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02361892_inc_R1",
"type": "Has_mood",
"arg1_id": "NCT02361892_inc_T5",
"arg2_id": "NCT02361892_inc_T4",
"normalized": []
}
] |
NCT02361905_exc | NCT02361905 | [
{
"id": "NCT02361905_exc_text",
"type": "exclusion",
"text": [
"submucosal leiomyoma,\nendometrial hyperplasia with atypia,\nhistory of uterine surgery\n"
],
"offsets": [
[
0,
86
]
]
}
] | [
{
"id": "NCT02361905_exc_T1",
"type": "Condition",
"text": [
"submucosal leiomyoma"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "NCT02361905_exc_T2",
"type": "Condition",
"text": [
"endometrial hyperplasia"
],
"offsets": [
[
22,
45
]
],
"normalized": []
},
{
"id": "NCT02361905_exc_T3",
"type": "Qualifier",
"text": [
"with atypia"
],
"offsets": [
[
46,
57
]
],
"normalized": []
},
{
"id": "NCT02361905_exc_T4",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
59,
66
]
],
"normalized": []
},
{
"id": "NCT02361905_exc_T5",
"type": "Procedure",
"text": [
"uterine surgery"
],
"offsets": [
[
70,
85
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02361905_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02361905_exc_T2",
"arg2_id": "NCT02361905_exc_T3",
"normalized": []
},
{
"id": "NCT02361905_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02361905_exc_T5",
"arg2_id": "NCT02361905_exc_T4",
"normalized": []
}
] |
NCT02361905_inc | NCT02361905 | [
{
"id": "NCT02361905_inc_text",
"type": "inclusion",
"text": [
"hypoechoic uterine leiomyoma (echogenicity <3),\nintramural leiomyomas with an ultrasonographic size <20 cm but >4cm,\nindication to surgery (symptoms of menometrorrhagia,\nmenstrual disorder,\ninfertility,\npelvic pain or pelvic pressure\n"
],
"offsets": [
[
0,
234
]
]
}
] | [
{
"id": "NCT02361905_inc_T1",
"type": "Condition",
"text": [
"uterine leiomyoma"
],
"offsets": [
[
11,
28
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T2",
"type": "Qualifier",
"text": [
"hypoechoic"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T3",
"type": "Measurement",
"text": [
"echogenicity"
],
"offsets": [
[
30,
42
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T4",
"type": "Value",
"text": [
"<3"
],
"offsets": [
[
43,
45
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T5",
"type": "Scope",
"text": [
"echogenicity <3"
],
"offsets": [
[
30,
45
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T6",
"type": "Condition",
"text": [
"intramural leiomyomas"
],
"offsets": [
[
48,
69
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T7",
"type": "Measurement",
"text": [
"ultrasonographic size"
],
"offsets": [
[
78,
99
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T8",
"type": "Value",
"text": [
"<20 cm but >4cm"
],
"offsets": [
[
100,
115
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T9",
"type": "Mood",
"text": [
"indication to"
],
"offsets": [
[
117,
130
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T10",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
131,
138
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T11",
"type": "Condition",
"text": [
"menometrorrhagia"
],
"offsets": [
[
152,
168
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T12",
"type": "Condition",
"text": [
"menstrual disorder"
],
"offsets": [
[
170,
188
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T13",
"type": "Condition",
"text": [
"infertility"
],
"offsets": [
[
190,
201
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T14",
"type": "Condition",
"text": [
"pelvic pain"
],
"offsets": [
[
203,
214
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T15",
"type": "Condition",
"text": [
"pelvic pressure"
],
"offsets": [
[
218,
233
]
],
"normalized": []
},
{
"id": "NCT02361905_inc_T16",
"type": "Scope",
"text": [
"indication to surgery"
],
"offsets": [
[
117,
138
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02361905_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02361905_inc_T1",
"arg2_id": "NCT02361905_inc_T2",
"normalized": []
},
{
"id": "NCT02361905_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02361905_inc_T3",
"arg2_id": "NCT02361905_inc_T4",
"normalized": []
},
{
"id": "NCT02361905_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02361905_inc_T2",
"arg2_id": "NCT02361905_inc_T5",
"normalized": []
},
{
"id": "NCT02361905_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02361905_inc_T7",
"arg2_id": "NCT02361905_inc_T8",
"normalized": []
},
{
"id": "NCT02361905_inc_R5",
"type": "Has_mood",
"arg1_id": "NCT02361905_inc_T10",
"arg2_id": "NCT02361905_inc_T9",
"normalized": []
},
{
"id": "NCT02361905_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02361905_inc_T16",
"arg2_id": "NCT02361905_inc_T11",
"normalized": []
}
] |
NCT02364648_exc | NCT02364648 | [
{
"id": "NCT02364648_exc_text",
"type": "exclusion",
"text": [
"History of cardiovascular disease;\nCurrent pregnancy;\nUncontrolled hypertension;\nUncontrolled hyperlipidemia;\nCurrent hormone replacement therapy;\nCurrent use of tobacco products;\nElevated liver enzymes;\nCurrent autoimmune disease;\nDaily use of of antioxidants >300mg\n"
],
"offsets": [
[
0,
268
]
]
}
] | [
{
"id": "NCT02364648_exc_T1",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
11,
33
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T2",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T3",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
35,
42
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T4",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
43,
52
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T5",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
67,
79
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T6",
"type": "Qualifier",
"text": [
"Uncontrolled"
],
"offsets": [
[
54,
66
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T7",
"type": "Qualifier",
"text": [
"Uncontrolled"
],
"offsets": [
[
81,
93
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T8",
"type": "Condition",
"text": [
"hyperlipidemia"
],
"offsets": [
[
94,
108
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T9",
"type": "Procedure",
"text": [
"hormone replacement therapy"
],
"offsets": [
[
118,
145
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T10",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T11",
"type": "Observation",
"text": [
"use of tobacco products"
],
"offsets": [
[
155,
178
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T12",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
147,
154
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T13",
"type": "Condition",
"text": [
"Elevated liver enzymes"
],
"offsets": [
[
180,
202
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T14",
"type": "Condition",
"text": [
"autoimmune disease"
],
"offsets": [
[
212,
230
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T15",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
204,
211
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T16",
"type": "Multiplier",
"text": [
"Daily use"
],
"offsets": [
[
232,
241
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T17",
"type": "Drug",
"text": [
"antioxidants"
],
"offsets": [
[
248,
260
]
],
"normalized": []
},
{
"id": "NCT02364648_exc_T18",
"type": "Multiplier",
"text": [
">300mg"
],
"offsets": [
[
261,
267
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02364648_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02364648_exc_T4",
"arg2_id": "NCT02364648_exc_T3",
"normalized": []
},
{
"id": "NCT02364648_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02364648_exc_T5",
"arg2_id": "NCT02364648_exc_T6",
"normalized": []
},
{
"id": "NCT02364648_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02364648_exc_T8",
"arg2_id": "NCT02364648_exc_T7",
"normalized": []
},
{
"id": "NCT02364648_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02364648_exc_T9",
"arg2_id": "NCT02364648_exc_T10",
"normalized": []
},
{
"id": "NCT02364648_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02364648_exc_T11",
"arg2_id": "NCT02364648_exc_T12",
"normalized": []
},
{
"id": "NCT02364648_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02364648_exc_T14",
"arg2_id": "NCT02364648_exc_T15",
"normalized": []
},
{
"id": "NCT02364648_exc_R7",
"type": "Has_multiplier",
"arg1_id": "NCT02364648_exc_T17",
"arg2_id": "NCT02364648_exc_T18",
"normalized": []
},
{
"id": "NCT02364648_exc_R8",
"type": "Has_multiplier",
"arg1_id": "NCT02364648_exc_T17",
"arg2_id": "NCT02364648_exc_T16",
"normalized": []
}
] |
NCT02364648_inc | NCT02364648 | [
{
"id": "NCT02364648_inc_text",
"type": "inclusion",
"text": [
"Stage 3 - 5 Chronic Kidney Disease\n"
],
"offsets": [
[
0,
35
]
]
}
] | [
{
"id": "NCT02364648_inc_T1",
"type": "Condition",
"text": [
"Chronic Kidney Disease"
],
"offsets": [
[
12,
34
]
],
"normalized": []
},
{
"id": "NCT02364648_inc_T2",
"type": "Measurement",
"text": [
"Stage"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02364648_inc_T3",
"type": "Value",
"text": [
"3 - 5"
],
"offsets": [
[
6,
11
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02364648_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02364648_inc_T2",
"arg2_id": "NCT02364648_inc_T3",
"normalized": []
},
{
"id": "NCT02364648_inc_R2",
"type": "AND",
"arg1_id": "NCT02364648_inc_T1",
"arg2_id": "NCT02364648_inc_T2",
"normalized": []
}
] |
NCT02365870_exc | NCT02365870 | [
{
"id": "NCT02365870_exc_text",
"type": "exclusion",
"text": [
"Unstable medical disease of comorbid psychiatric disease\nDementia\nSubjects with less than one year duration of Parkinson's\nCurrent treatment with a dopamine agonist\n"
],
"offsets": [
[
0,
165
]
]
}
] | [
{
"id": "NCT02365870_exc_T1",
"type": "Condition",
"text": [
"Unstable medical disease"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T2",
"type": "Condition",
"text": [
"comorbid psychiatric disease"
],
"offsets": [
[
28,
56
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T3",
"type": "Condition",
"text": [
"Dementia"
],
"offsets": [
[
57,
65
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T4",
"type": "Multiplier",
"text": [
"less than one year duration"
],
"offsets": [
[
80,
107
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T5",
"type": "Condition",
"text": [
"Parkinson's"
],
"offsets": [
[
111,
122
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T6",
"type": "Drug",
"text": [
"dopamine agonist"
],
"offsets": [
[
148,
164
]
],
"normalized": []
},
{
"id": "NCT02365870_exc_T7",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
123,
130
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02365870_exc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02365870_exc_T5",
"arg2_id": "NCT02365870_exc_T4",
"normalized": []
},
{
"id": "NCT02365870_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02365870_exc_T6",
"arg2_id": "NCT02365870_exc_T7",
"normalized": []
}
] |
NCT02365870_inc | NCT02365870 | [
{
"id": "NCT02365870_inc_text",
"type": "inclusion",
"text": [
"Diagnosis of DSM 5 Anxiety Disorder\nStable medical history and general health\nOn stable anti-parkinsonian therapy for 2 weeks before enrollment\n"
],
"offsets": [
[
0,
144
]
]
}
] | [
{
"id": "NCT02365870_inc_T1",
"type": "Condition",
"text": [
"DSM 5 Anxiety Disorder"
],
"offsets": [
[
13,
35
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T2",
"type": "Observation",
"text": [
"Stable medical history"
],
"offsets": [
[
36,
58
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T3",
"type": "Condition",
"text": [
"table",
"eneral health"
],
"offsets": [
[
37,
42
],
[
64,
77
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T4",
"type": "Qualifier",
"text": [
"stable"
],
"offsets": [
[
81,
87
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T5",
"type": "Procedure",
"text": [
"anti-parkinsonian therapy"
],
"offsets": [
[
88,
113
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T6",
"type": "Multiplier",
"text": [
"for 2 weeks"
],
"offsets": [
[
114,
125
]
],
"normalized": []
},
{
"id": "NCT02365870_inc_T7",
"type": "Temporal",
"text": [
"before enrollment"
],
"offsets": [
[
126,
143
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02365870_inc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02365870_inc_T5",
"arg2_id": "NCT02365870_inc_T6",
"normalized": []
},
{
"id": "NCT02365870_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02365870_inc_T5",
"arg2_id": "NCT02365870_inc_T4",
"normalized": []
},
{
"id": "NCT02365870_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02365870_inc_T5",
"arg2_id": "NCT02365870_inc_T7",
"normalized": []
}
] |
NCT02366819_exc | NCT02366819 | [
{
"id": "NCT02366819_exc_text",
"type": "exclusion",
"text": [
"Previous or concurrent malignancy, except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or any other cancer for which the patient has been previously treated and the lifetime recurrence risk is less than 30%\nInflammatory bowel disease that is uncontrolled or on active treatment (Crohn's disease, ulcerative colitis)\nDiarrhea, grade 1 or greater by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE, version [v] 4.0)\nNeuropathy, grade 2 or greater by NCI-CTCAE, v 4.0\nSerious underlying medical or psychiatric illnesses that would, in the opinion of the treating physician, substantially increase the risk for complications related to treatment\nActive uncontrolled bleeding\nPregnancy or breastfeeding\nMajor surgery within 4 weeks\nPatients with any polymorphism in UGT1A1 other than *1 or *28 (e.g, *6) will be allowed and treated as in the *28/*28 dosing group\n"
],
"offsets": [
[
0,
942
]
]
}
] | [
{
"id": "NCT02366819_exc_T1",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
23,
33
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T2",
"type": "Qualifier",
"text": [
"Previous"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T3",
"type": "Qualifier",
"text": [
"concurrent"
],
"offsets": [
[
12,
22
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T4",
"type": "Scope",
"text": [
"Previous or concurrent"
],
"offsets": [
[
0,
22
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T5",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T6",
"type": "Condition",
"text": [
"squamous cell skin cancer"
],
"offsets": [
[
79,
104
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T7",
"type": "Condition",
"text": [
"basal cell",
"skin cancer"
],
"offsets": [
[
65,
75
],
[
93,
104
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T8",
"type": "Condition",
"text": [
"cervical cancer"
],
"offsets": [
[
114,
129
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T9",
"type": "Qualifier",
"text": [
"in situ"
],
"offsets": [
[
106,
113
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T10",
"type": "Qualifier",
"text": [
"adequately treated"
],
"offsets": [
[
46,
64
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T11",
"type": "Scope",
"text": [
"basal cell or squamous cell skin cancer"
],
"offsets": [
[
65,
104
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T13",
"type": "Scope",
"text": [
"adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer"
],
"offsets": [
[
46,
129
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T14",
"type": "Condition",
"text": [
"Inflammatory bowel disease"
],
"offsets": [
[
251,
277
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T15",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
286,
298
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T16",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
312,
321
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T18",
"type": "Condition",
"text": [
"Crohn's disease"
],
"offsets": [
[
323,
338
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T19",
"type": "Condition",
"text": [
"ulcerative colitis"
],
"offsets": [
[
340,
358
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T20",
"type": "Scope",
"text": [
"Crohn's disease, ulcerative colitis"
],
"offsets": [
[
323,
358
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T21",
"type": "Scope",
"text": [
"Inflammatory bowel disease that is uncontrolled or on active treatment"
],
"offsets": [
[
251,
321
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T22",
"type": "Condition",
"text": [
"Diarrhea"
],
"offsets": [
[
360,
368
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T23",
"type": "Measurement",
"text": [
"National Cancer Institute Common Terminology Criteria for Adverse Events"
],
"offsets": [
[
396,
468
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T24",
"type": "Value",
"text": [
"grade 1 or greater"
],
"offsets": [
[
370,
388
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T25",
"type": "Measurement",
"text": [
"NCI-CTCAE, version [v] 4.0"
],
"offsets": [
[
470,
496
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T26",
"type": "Condition",
"text": [
"Neuropathy"
],
"offsets": [
[
498,
508
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T27",
"type": "Measurement",
"text": [
"NCI-CTCAE, v 4.0"
],
"offsets": [
[
532,
548
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T28",
"type": "Value",
"text": [
"grade 2 or greater"
],
"offsets": [
[
510,
528
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T30",
"type": "Condition",
"text": [
"bleeding"
],
"offsets": [
[
746,
754
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T31",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
726,
732
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T32",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
733,
745
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T34",
"type": "Procedure",
"text": [
"Major surgery"
],
"offsets": [
[
782,
795
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T35",
"type": "Temporal",
"text": [
"within 4 weeks"
],
"offsets": [
[
796,
810
]
],
"normalized": []
},
{
"id": "NCT02366819_exc_T17",
"type": "Scope",
"text": [
"uncontrolled or on active treatment"
],
"offsets": [
[
286,
321
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02366819_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_exc_T8",
"arg2_id": "NCT02366819_exc_T9",
"normalized": []
},
{
"id": "NCT02366819_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_exc_T11",
"arg2_id": "NCT02366819_exc_T10",
"normalized": []
},
{
"id": "NCT02366819_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02366819_exc_T13",
"arg2_id": "NCT02366819_exc_T5",
"normalized": []
},
{
"id": "NCT02366819_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02366819_exc_T1",
"arg2_id": "NCT02366819_exc_T4",
"normalized": []
},
{
"id": "NCT02366819_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT02366819_exc_T21",
"arg2_id": "NCT02366819_exc_T20",
"normalized": []
},
{
"id": "NCT02366819_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02366819_exc_T23",
"arg2_id": "NCT02366819_exc_T24",
"normalized": []
},
{
"id": "NCT02366819_exc_R9",
"type": "AND",
"arg1_id": "NCT02366819_exc_T22",
"arg2_id": "NCT02366819_exc_T23",
"normalized": []
},
{
"id": "NCT02366819_exc_R10",
"type": "Subsumes",
"arg1_id": "NCT02366819_exc_T23",
"arg2_id": "NCT02366819_exc_T25",
"normalized": []
},
{
"id": "NCT02366819_exc_R11",
"type": "AND",
"arg1_id": "NCT02366819_exc_T26",
"arg2_id": "NCT02366819_exc_T27",
"normalized": []
},
{
"id": "NCT02366819_exc_R12",
"type": "Has_value",
"arg1_id": "NCT02366819_exc_T27",
"arg2_id": "NCT02366819_exc_T28",
"normalized": []
},
{
"id": "NCT02366819_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_exc_T30",
"arg2_id": "NCT02366819_exc_T32",
"normalized": []
},
{
"id": "NCT02366819_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_exc_T30",
"arg2_id": "NCT02366819_exc_T31",
"normalized": []
},
{
"id": "NCT02366819_exc_R15",
"type": "Has_temporal",
"arg1_id": "NCT02366819_exc_T34",
"arg2_id": "NCT02366819_exc_T35",
"normalized": []
},
{
"id": "NCT02366819_exc_R5",
"type": "Has_scope",
"arg1_id": "NCT02366819_exc_T14",
"arg2_id": "NCT02366819_exc_T17",
"normalized": []
}
] |
NCT02366819_inc | NCT02366819 | [
{
"id": "NCT02366819_inc_text",
"type": "inclusion",
"text": [
"Histologically confirmed locally advanced gastric (primary endpoint includes proximal and mid-body stomach) or esophagogastric adenocarcinoma; distal gastric (antral) adenocarcinomas are eligible for enrolment but will not be included in the primary analysis\nLocally advanced disease as determined by endoscopic ultrasound (EUS) stage > primary tumor (T) 3 and/or any T, lymph nodes (N)+ disease without metastatic disease (Mx)\nAll patients must have diagnostic laparoscopy with diagnostic washings for cytology; both cytology positive and negative patients are eligible for enrolment, but only cytology negative patients will be included in the primary analyses; gross peritoneal disease is not eligible\nEastern Cooperative Oncology Group (ECOG) performance status =< 1\nEligible for surgery with curative intent\nAbsolute neutrophil count (ANC) >= 1250/ul\nHemoglobin >= 9 g/dL\nPlatelets >= 100,000/ul\nTotal bilirubin < 1.5 x upper limit of normal\nSerum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) < 2.5 x upper limit of normal for patients without liver metastases OR SGOT and SGPT < 5 x upper limit of normal for patients with liver metastases\nCreatinine =< 1.5 x upper limit of normal\nMeasurable or non-measurable disease by Response Evaluation Criteria in Solid Tumor (RECIST) 1.1 will be allowed\nWomen of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation, up until 30 days after final study treatment; should a woman become pregnant or suspect that she is pregnant while participating in this study, she should inform her treating physician immediately\nPatients taking substrates, inhibitors, or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) should be encouraged to switch to alternative drugs whenever possible, given the potential for drug-drug interactions with irinotecan\nSigned informed consent\n"
],
"offsets": [
[
0,
2025
]
]
}
] | [
{
"id": "NCT02366819_inc_T1",
"type": "Condition",
"text": [
"esophagogastric adenocarcinoma"
],
"offsets": [
[
111,
141
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T2",
"type": "Condition",
"text": [
"adenocarcinoma",
"gastric"
],
"offsets": [
[
127,
141
],
[
42,
49
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T3",
"type": "Qualifier",
"text": [
"locally advanced"
],
"offsets": [
[
25,
41
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T4",
"type": "Scope",
"text": [
"gastric (primary endpoint includes proximal and mid-body stomach) or esophagogastric adenocarcinoma"
],
"offsets": [
[
42,
141
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T5",
"type": "Qualifier",
"text": [
"mid-body stomach"
],
"offsets": [
[
90,
106
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T6",
"type": "Qualifier",
"text": [
"proximal",
"stomach"
],
"offsets": [
[
77,
85
],
[
99,
106
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T7",
"type": "Scope",
"text": [
"proximal and mid-body stomach"
],
"offsets": [
[
77,
106
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T8",
"type": "Condition",
"text": [
"adenocarcinomas"
],
"offsets": [
[
167,
182
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T9",
"type": "Qualifier",
"text": [
"distal gastric"
],
"offsets": [
[
143,
157
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T10",
"type": "Qualifier",
"text": [
"antral"
],
"offsets": [
[
159,
165
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T12",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
276,
283
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T13",
"type": "Qualifier",
"text": [
"Locally advanced"
],
"offsets": [
[
259,
275
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T14",
"type": "Procedure",
"text": [
"endoscopic ultrasound"
],
"offsets": [
[
301,
322
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T15",
"type": "Value",
"text": [
"> primary tumor (T) 3 and/or any T, lymph nodes (N)+ disease without metastatic disease (Mx)"
],
"offsets": [
[
335,
427
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T16",
"type": "Procedure",
"text": [
"EUS"
],
"offsets": [
[
324,
327
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T17",
"type": "Procedure",
"text": [
"laparoscopy"
],
"offsets": [
[
462,
473
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T18",
"type": "Qualifier",
"text": [
"diagnostic"
],
"offsets": [
[
451,
461
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T19",
"type": "Procedure",
"text": [
"washings for cytology"
],
"offsets": [
[
490,
511
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T20",
"type": "Measurement",
"text": [
"cytology"
],
"offsets": [
[
518,
526
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T21",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
527,
535
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T22",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
540,
548
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T23",
"type": "Scope",
"text": [
"positive and negative"
],
"offsets": [
[
527,
548
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T25",
"type": "Measurement",
"text": [
"tern Cooperative Oncology Group (E",
"formance status =<"
],
"offsets": [
[
708,
742
],
[
750,
768
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T26",
"type": "Value",
"text": [
"=< 1"
],
"offsets": [
[
766,
770
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T27",
"type": "Measurement",
"text": [
"ECOG"
],
"offsets": [
[
741,
745
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T28",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
784,
791
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T29",
"type": "Qualifier",
"text": [
"curative"
],
"offsets": [
[
797,
805
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T30",
"type": "Measurement",
"text": [
"Absolute neutrophil count"
],
"offsets": [
[
813,
838
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T31",
"type": "Measurement",
"text": [
"ANC"
],
"offsets": [
[
840,
843
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T32",
"type": "Value",
"text": [
">= 1250/ul"
],
"offsets": [
[
845,
855
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T33",
"type": "Measurement",
"text": [
"Hemoglobin"
],
"offsets": [
[
856,
866
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T34",
"type": "Value",
"text": [
">= 9 g/dL"
],
"offsets": [
[
867,
876
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T35",
"type": "Measurement",
"text": [
"Platelets"
],
"offsets": [
[
877,
886
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T36",
"type": "Value",
"text": [
">= 100,000/ul"
],
"offsets": [
[
887,
900
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T37",
"type": "Measurement",
"text": [
"Total bilirubin"
],
"offsets": [
[
901,
916
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T38",
"type": "Value",
"text": [
"< 1.5 x upper limit of normal"
],
"offsets": [
[
917,
946
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T39",
"type": "Measurement",
"text": [
"Serum glutamic oxaloacetic transaminase"
],
"offsets": [
[
947,
986
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T40",
"type": "Measurement",
"text": [
"SGOT"
],
"offsets": [
[
988,
992
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T41",
"type": "Measurement",
"text": [
"serum glutamate pyruvate transaminase"
],
"offsets": [
[
998,
1035
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T42",
"type": "Measurement",
"text": [
"SGPT"
],
"offsets": [
[
1037,
1041
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T43",
"type": "Value",
"text": [
"< 2.5 x upper limit of normal"
],
"offsets": [
[
1043,
1072
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T44",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
1086,
1093
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T45",
"type": "Condition",
"text": [
"liver metastases"
],
"offsets": [
[
1094,
1110
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T46",
"type": "Measurement",
"text": [
"SGOT"
],
"offsets": [
[
1114,
1118
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T47",
"type": "Measurement",
"text": [
"SGPT"
],
"offsets": [
[
1123,
1127
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T48",
"type": "Value",
"text": [
"< 5 x upper limit of normal"
],
"offsets": [
[
1128,
1155
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T49",
"type": "Condition",
"text": [
"liver metastases"
],
"offsets": [
[
1174,
1190
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T50",
"type": "Scope",
"text": [
"Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT)"
],
"offsets": [
[
947,
1042
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T51",
"type": "Scope",
"text": [
"SGOT and SGPT"
],
"offsets": [
[
1114,
1127
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T52",
"type": "Measurement",
"text": [
"Creatinine"
],
"offsets": [
[
1191,
1201
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T53",
"type": "Value",
"text": [
"=< 1.5 x upper limit of normal"
],
"offsets": [
[
1202,
1232
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T54",
"type": "Measurement",
"text": [
"Response Evaluation Criteria in Solid Tumor"
],
"offsets": [
[
1273,
1316
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T55",
"type": "Measurement",
"text": [
"RECIST"
],
"offsets": [
[
1318,
1324
]
],
"normalized": []
},
{
"id": "NCT02366819_inc_T56",
"type": "Value",
"text": [
"1.1"
],
"offsets": [
[
1326,
1329
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02366819_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_inc_T4",
"arg2_id": "NCT02366819_inc_T3",
"normalized": []
},
{
"id": "NCT02366819_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02366819_inc_T2",
"arg2_id": "NCT02366819_inc_T7",
"normalized": []
},
{
"id": "NCT02366819_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T9",
"arg2_id": "NCT02366819_inc_T10",
"normalized": []
},
{
"id": "NCT02366819_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_inc_T8",
"arg2_id": "NCT02366819_inc_T9",
"normalized": []
},
{
"id": "NCT02366819_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_inc_T12",
"arg2_id": "NCT02366819_inc_T13",
"normalized": []
},
{
"id": "NCT02366819_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T14",
"arg2_id": "NCT02366819_inc_T15",
"normalized": []
},
{
"id": "NCT02366819_inc_R7",
"type": "AND",
"arg1_id": "NCT02366819_inc_T12",
"arg2_id": "NCT02366819_inc_T14",
"normalized": []
},
{
"id": "NCT02366819_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T14",
"arg2_id": "NCT02366819_inc_T16",
"normalized": []
},
{
"id": "NCT02366819_inc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_inc_T17",
"arg2_id": "NCT02366819_inc_T18",
"normalized": []
},
{
"id": "NCT02366819_inc_R10",
"type": "Has_scope",
"arg1_id": "NCT02366819_inc_T20",
"arg2_id": "NCT02366819_inc_T23",
"normalized": []
},
{
"id": "NCT02366819_inc_R11",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T25",
"arg2_id": "NCT02366819_inc_T27",
"normalized": []
},
{
"id": "NCT02366819_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T25",
"arg2_id": "NCT02366819_inc_T26",
"normalized": []
},
{
"id": "NCT02366819_inc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02366819_inc_T28",
"arg2_id": "NCT02366819_inc_T29",
"normalized": []
},
{
"id": "NCT02366819_inc_R14",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T30",
"arg2_id": "NCT02366819_inc_T31",
"normalized": []
},
{
"id": "NCT02366819_inc_R15",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T30",
"arg2_id": "NCT02366819_inc_T32",
"normalized": []
},
{
"id": "NCT02366819_inc_R16",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T33",
"arg2_id": "NCT02366819_inc_T34",
"normalized": []
},
{
"id": "NCT02366819_inc_R17",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T35",
"arg2_id": "NCT02366819_inc_T36",
"normalized": []
},
{
"id": "NCT02366819_inc_R18",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T37",
"arg2_id": "NCT02366819_inc_T38",
"normalized": []
},
{
"id": "NCT02366819_inc_R19",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T39",
"arg2_id": "NCT02366819_inc_T40",
"normalized": []
},
{
"id": "NCT02366819_inc_R20",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T41",
"arg2_id": "NCT02366819_inc_T42",
"normalized": []
},
{
"id": "NCT02366819_inc_R21",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T50",
"arg2_id": "NCT02366819_inc_T43",
"normalized": []
},
{
"id": "NCT02366819_inc_R22",
"type": "Has_negation",
"arg1_id": "NCT02366819_inc_T45",
"arg2_id": "NCT02366819_inc_T44",
"normalized": []
},
{
"id": "NCT02366819_inc_R23",
"type": "Has_scope",
"arg1_id": "NCT02366819_inc_T45",
"arg2_id": "NCT02366819_inc_T50",
"normalized": []
},
{
"id": "NCT02366819_inc_R24",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T51",
"arg2_id": "NCT02366819_inc_T48",
"normalized": []
},
{
"id": "NCT02366819_inc_R25",
"type": "Has_scope",
"arg1_id": "NCT02366819_inc_T49",
"arg2_id": "NCT02366819_inc_T51",
"normalized": []
},
{
"id": "NCT02366819_inc_R26",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T52",
"arg2_id": "NCT02366819_inc_T53",
"normalized": []
},
{
"id": "NCT02366819_inc_R27",
"type": "Subsumes",
"arg1_id": "NCT02366819_inc_T54",
"arg2_id": "NCT02366819_inc_T55",
"normalized": []
},
{
"id": "NCT02366819_inc_R28",
"type": "Has_value",
"arg1_id": "NCT02366819_inc_T54",
"arg2_id": "NCT02366819_inc_T56",
"normalized": []
}
] |
NCT02368743_exc | NCT02368743 | [
{
"id": "NCT02368743_exc_text",
"type": "exclusion",
"text": [
"Patient included in an interventional study assessing treatment for active proctitis or distal proctosigmoiditis. \nPatient with left sided, colitis or pancolitis. \nPatient with severe proctitis (MAYO score ≥ 11 at inclusion). \nPatient previously treated with biologics. \nPatient treated with immunosuppressive within 1 month before study inclusion. \nPatient treated with corticosteroids within 2 weeks before study inclusion. \n \n"
],
"offsets": [
[
0,
438
]
]
}
] | [
{
"id": "NCT02368743_exc_T1",
"type": "Condition",
"text": [
"active proctitis"
],
"offsets": [
[
68,
84
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T2",
"type": "Condition",
"text": [
"distal proctosigmoiditis"
],
"offsets": [
[
88,
112
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T3",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
54,
63
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T5",
"type": "Scope",
"text": [
"active proctitis or distal proctosigmoiditis"
],
"offsets": [
[
68,
112
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T6",
"type": "Condition",
"text": [
"colitis"
],
"offsets": [
[
140,
147
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T7",
"type": "Condition",
"text": [
"pancolitis"
],
"offsets": [
[
151,
161
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T8",
"type": "Qualifier",
"text": [
"left sided"
],
"offsets": [
[
128,
138
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T9",
"type": "Scope",
"text": [
"colitis or pancolitis"
],
"offsets": [
[
140,
161
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T10",
"type": "Condition",
"text": [
"proctitis"
],
"offsets": [
[
184,
193
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T11",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
177,
183
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T12",
"type": "Measurement",
"text": [
"MAYO score"
],
"offsets": [
[
195,
205
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T13",
"type": "Value",
"text": [
"≥ 11"
],
"offsets": [
[
206,
210
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T14",
"type": "Temporal",
"text": [
"at inclusion"
],
"offsets": [
[
211,
223
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T15",
"type": "Drug",
"text": [
"biologics"
],
"offsets": [
[
259,
268
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T17",
"type": "Temporal",
"text": [
"previously"
],
"offsets": [
[
235,
245
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T18",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
246,
253
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T19",
"type": "Drug",
"text": [
"immunosuppressive"
],
"offsets": [
[
292,
309
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T20",
"type": "Temporal",
"text": [
"within 1 month before study inclusion"
],
"offsets": [
[
310,
347
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T21",
"type": "Reference_point",
"text": [
"study inclusion"
],
"offsets": [
[
332,
347
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T22",
"type": "Drug",
"text": [
"corticosteroids"
],
"offsets": [
[
371,
386
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T23",
"type": "Temporal",
"text": [
"within 2 weeks before study inclusion"
],
"offsets": [
[
387,
424
]
],
"normalized": []
},
{
"id": "NCT02368743_exc_T24",
"type": "Reference_point",
"text": [
"study inclusion"
],
"offsets": [
[
409,
424
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02368743_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT02368743_exc_T3",
"arg2_id": "NCT02368743_exc_T5",
"normalized": []
},
{
"id": "NCT02368743_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02368743_exc_T9",
"arg2_id": "NCT02368743_exc_T8",
"normalized": []
},
{
"id": "NCT02368743_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02368743_exc_T10",
"arg2_id": "NCT02368743_exc_T11",
"normalized": []
},
{
"id": "NCT02368743_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02368743_exc_T12",
"arg2_id": "NCT02368743_exc_T13",
"normalized": []
},
{
"id": "NCT02368743_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02368743_exc_T12",
"arg2_id": "NCT02368743_exc_T14",
"normalized": []
},
{
"id": "NCT02368743_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02368743_exc_T11",
"arg2_id": "NCT02368743_exc_T12",
"normalized": []
},
{
"id": "NCT02368743_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02368743_exc_T18",
"arg2_id": "NCT02368743_exc_T17",
"normalized": []
},
{
"id": "NCT02368743_exc_R8",
"type": "AND",
"arg1_id": "NCT02368743_exc_T18",
"arg2_id": "NCT02368743_exc_T15",
"normalized": []
},
{
"id": "NCT02368743_exc_R9",
"type": "Has_index",
"arg1_id": "NCT02368743_exc_T20",
"arg2_id": "NCT02368743_exc_T21",
"normalized": []
},
{
"id": "NCT02368743_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02368743_exc_T19",
"arg2_id": "NCT02368743_exc_T20",
"normalized": []
},
{
"id": "NCT02368743_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02368743_exc_T23",
"arg2_id": "NCT02368743_exc_T24",
"normalized": []
},
{
"id": "NCT02368743_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02368743_exc_T22",
"arg2_id": "NCT02368743_exc_T23",
"normalized": []
}
] |
NCT02368743_inc | NCT02368743 | [
{
"id": "NCT02368743_inc_text",
"type": "inclusion",
"text": [
"Patient aged 18 years or older. \nPatient suffering from mild to moderate active proctitis or distal proctosigmoiditis (MAYO score ≥ 3 and ≤ 10) at inclusion based on clinical and endoscopic findings within 6 months before study inclusion. \nPatient with evidence of endoscopic active proctitis or distal proctosigmoiditis (Montreal classification E1 or E2 defined by an involvement not exceeding 25 cm from the anal margin) within 6 months before study inclusion. \nTreatment of the current flare with Pentasa® to induce a remission initiated by the patient, the general practitioner or the gastroenterologist, during the inclusion visit or during the week before the inclusion visit. \nPatient having received oral and written information on the study, without any objections for the use of his/her personal data, and having signed a written Informed Consent Form. \n"
],
"offsets": [
[
0,
864
]
]
}
] | [
{
"id": "NCT02368743_inc_T1",
"type": "Value",
"text": [
"18 years or older"
],
"offsets": [
[
13,
30
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T2",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
8,
12
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T3",
"type": "Condition",
"text": [
"active proctitis"
],
"offsets": [
[
73,
89
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T4",
"type": "Condition",
"text": [
"distal proctosigmoiditis"
],
"offsets": [
[
93,
117
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T5",
"type": "Qualifier",
"text": [
"mild to moderate"
],
"offsets": [
[
56,
72
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T6",
"type": "Scope",
"text": [
"active proctitis or distal proctosigmoiditis"
],
"offsets": [
[
73,
117
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T7",
"type": "Measurement",
"text": [
"MAYO score"
],
"offsets": [
[
119,
129
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T8",
"type": "Value",
"text": [
"≥ 3 and ≤ 10"
],
"offsets": [
[
130,
142
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T9",
"type": "Temporal",
"text": [
"within 6 months before study inclusion"
],
"offsets": [
[
199,
237
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T10",
"type": "Reference_point",
"text": [
"study inclusion"
],
"offsets": [
[
222,
237
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T11",
"type": "Temporal",
"text": [
"at inclusion"
],
"offsets": [
[
144,
156
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T12",
"type": "Reference_point",
"text": [
"inclusion"
],
"offsets": [
[
147,
156
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T13",
"type": "Condition",
"text": [
"active proctitis"
],
"offsets": [
[
276,
292
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T14",
"type": "Condition",
"text": [
"distal proctosigmoiditis"
],
"offsets": [
[
296,
320
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T15",
"type": "Procedure",
"text": [
"endoscopic"
],
"offsets": [
[
265,
275
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T16",
"type": "Scope",
"text": [
"active proctitis or distal proctosigmoiditis"
],
"offsets": [
[
276,
320
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T17",
"type": "Measurement",
"text": [
"Montreal classification"
],
"offsets": [
[
322,
345
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T18",
"type": "Value",
"text": [
"E1 or E2"
],
"offsets": [
[
346,
354
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T19",
"type": "Qualifier",
"text": [
"involvement not exceeding 25 cm from the anal margin"
],
"offsets": [
[
369,
421
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T20",
"type": "Temporal",
"text": [
"within 6 months before study inclusion"
],
"offsets": [
[
423,
461
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T21",
"type": "Reference_point",
"text": [
"study inclusion"
],
"offsets": [
[
446,
461
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T22",
"type": "Drug",
"text": [
"Pentasa"
],
"offsets": [
[
500,
507
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T23",
"type": "Procedure",
"text": [
"Treatment"
],
"offsets": [
[
464,
473
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T24",
"type": "Condition",
"text": [
"flare"
],
"offsets": [
[
489,
494
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T25",
"type": "Temporal",
"text": [
"during the inclusion visit"
],
"offsets": [
[
609,
635
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T26",
"type": "Reference_point",
"text": [
"inclusion visit"
],
"offsets": [
[
620,
635
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T27",
"type": "Temporal",
"text": [
"during the week before the inclusion visit"
],
"offsets": [
[
639,
681
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T28",
"type": "Reference_point",
"text": [
"the week before the inclusion visit"
],
"offsets": [
[
646,
681
]
],
"normalized": []
},
{
"id": "NCT02368743_inc_T29",
"type": "Scope",
"text": [
"during the inclusion visit or during the week before the inclusion visit"
],
"offsets": [
[
609,
681
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02368743_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02368743_inc_T2",
"arg2_id": "NCT02368743_inc_T1",
"normalized": []
},
{
"id": "NCT02368743_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02368743_inc_T6",
"arg2_id": "NCT02368743_inc_T5",
"normalized": []
},
{
"id": "NCT02368743_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02368743_inc_T7",
"arg2_id": "NCT02368743_inc_T8",
"normalized": []
},
{
"id": "NCT02368743_inc_R4",
"type": "Has_index",
"arg1_id": "NCT02368743_inc_T9",
"arg2_id": "NCT02368743_inc_T10",
"normalized": []
},
{
"id": "NCT02368743_inc_R5",
"type": "Has_index",
"arg1_id": "NCT02368743_inc_T11",
"arg2_id": "NCT02368743_inc_T12",
"normalized": []
},
{
"id": "NCT02368743_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02368743_inc_T6",
"arg2_id": "NCT02368743_inc_T11",
"normalized": []
},
{
"id": "NCT02368743_inc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02368743_inc_T6",
"arg2_id": "NCT02368743_inc_T9",
"normalized": []
},
{
"id": "NCT02368743_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02368743_inc_T18",
"arg2_id": "NCT02368743_inc_T19",
"normalized": []
},
{
"id": "NCT02368743_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02368743_inc_T17",
"arg2_id": "NCT02368743_inc_T18",
"normalized": []
},
{
"id": "NCT02368743_inc_R10",
"type": "AND",
"arg1_id": "NCT02368743_inc_T16",
"arg2_id": "NCT02368743_inc_T17",
"normalized": []
},
{
"id": "NCT02368743_inc_R11",
"type": "AND",
"arg1_id": "NCT02368743_inc_T16",
"arg2_id": "NCT02368743_inc_T15",
"normalized": []
},
{
"id": "NCT02368743_inc_R12",
"type": "Has_index",
"arg1_id": "NCT02368743_inc_T20",
"arg2_id": "NCT02368743_inc_T21",
"normalized": []
},
{
"id": "NCT02368743_inc_R13",
"type": "AND",
"arg1_id": "NCT02368743_inc_T23",
"arg2_id": "NCT02368743_inc_T22",
"normalized": []
},
{
"id": "NCT02368743_inc_R14",
"type": "AND",
"arg1_id": "NCT02368743_inc_T24",
"arg2_id": "NCT02368743_inc_T23",
"normalized": []
},
{
"id": "NCT02368743_inc_R15",
"type": "Has_index",
"arg1_id": "NCT02368743_inc_T25",
"arg2_id": "NCT02368743_inc_T26",
"normalized": []
},
{
"id": "NCT02368743_inc_R16",
"type": "Has_index",
"arg1_id": "NCT02368743_inc_T27",
"arg2_id": "NCT02368743_inc_T28",
"normalized": []
},
{
"id": "NCT02368743_inc_R17",
"type": "Has_scope",
"arg1_id": "NCT02368743_inc_T23",
"arg2_id": "NCT02368743_inc_T29",
"normalized": []
}
] |
NCT02369211_exc | NCT02369211 | [
{
"id": "NCT02369211_exc_text",
"type": "exclusion",
"text": [
"Chronic opiate use\nLiver disease (known history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months)\nAllergy/hypersensitivity to acetaminophen\nPatients with baseline dementia\nChronic diathesis\nChronic kidney disease\n"
],
"offsets": [
[
0,
321
]
]
}
] | [
{
"id": "NCT02369211_exc_T1",
"type": "Multiplier",
"text": [
"Chronic"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T2",
"type": "Drug",
"text": [
"opiate"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T3",
"type": "Condition",
"text": [
"Liver disease"
],
"offsets": [
[
19,
32
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T4",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
40,
47
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T5",
"type": "Condition",
"text": [
"hepatitis B"
],
"offsets": [
[
51,
62
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T6",
"type": "Condition",
"text": [
"epatitis",
","
],
"offsets": [
[
52,
60
],
[
67,
68
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T7",
"type": "Condition",
"text": [
"cirrhosis"
],
"offsets": [
[
69,
78
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T8",
"type": "Condition",
"text": [
"nonalcoholic steatohepatitis"
],
"offsets": [
[
80,
108
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T9",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T10",
"type": "Condition",
"text": [
"alcoholism"
],
"offsets": [
[
121,
131
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T11",
"type": "Measurement",
"text": [
"ALT/AST"
],
"offsets": [
[
133,
140
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T12",
"type": "Value",
"text": [
"greater than 3 times upper limit of normal"
],
"offsets": [
[
141,
183
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T13",
"type": "Temporal",
"text": [
"in the past 3 months"
],
"offsets": [
[
184,
204
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T14",
"type": "Scope",
"text": [
"hepatitis B or C"
],
"offsets": [
[
51,
67
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T15",
"type": "Scope",
"text": [
"history of hepatitis B or C, cirrhosis, nonalcoholic steatohepatitis, history of alcoholism, ALT/AST greater than 3 times upper limit of normal in the past 3 months"
],
"offsets": [
[
40,
204
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T16",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
206,
213
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T17",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
214,
230
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T18",
"type": "Drug",
"text": [
"acetaminophen"
],
"offsets": [
[
234,
247
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T19",
"type": "Scope",
"text": [
"Allergy/hypersensitivity"
],
"offsets": [
[
206,
230
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T20",
"type": "Temporal",
"text": [
"baseline"
],
"offsets": [
[
262,
270
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T21",
"type": "Condition",
"text": [
"dementia"
],
"offsets": [
[
271,
279
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T22",
"type": "Condition",
"text": [
"diathesis"
],
"offsets": [
[
288,
297
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T23",
"type": "Qualifier",
"text": [
"Chronic"
],
"offsets": [
[
280,
287
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T24",
"type": "Qualifier",
"text": [
"Chronic"
],
"offsets": [
[
298,
305
]
],
"normalized": []
},
{
"id": "NCT02369211_exc_T25",
"type": "Condition",
"text": [
"kidney disease"
],
"offsets": [
[
306,
320
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02369211_exc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02369211_exc_T2",
"arg2_id": "NCT02369211_exc_T1",
"normalized": []
},
{
"id": "NCT02369211_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02369211_exc_T10",
"arg2_id": "NCT02369211_exc_T9",
"normalized": []
},
{
"id": "NCT02369211_exc_R3",
"type": "Has_value",
"arg1_id": "NCT02369211_exc_T11",
"arg2_id": "NCT02369211_exc_T12",
"normalized": []
},
{
"id": "NCT02369211_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02369211_exc_T11",
"arg2_id": "NCT02369211_exc_T13",
"normalized": []
},
{
"id": "NCT02369211_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02369211_exc_T14",
"arg2_id": "NCT02369211_exc_T4",
"normalized": []
},
{
"id": "NCT02369211_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02369211_exc_T3",
"arg2_id": "NCT02369211_exc_T15",
"normalized": []
},
{
"id": "NCT02369211_exc_R7",
"type": "AND",
"arg1_id": "NCT02369211_exc_T19",
"arg2_id": "NCT02369211_exc_T18",
"normalized": []
},
{
"id": "NCT02369211_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02369211_exc_T21",
"arg2_id": "NCT02369211_exc_T20",
"normalized": []
},
{
"id": "NCT02369211_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02369211_exc_T22",
"arg2_id": "NCT02369211_exc_T23",
"normalized": []
},
{
"id": "NCT02369211_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02369211_exc_T25",
"arg2_id": "NCT02369211_exc_T24",
"normalized": []
}
] |
NCT02369211_inc | NCT02369211 | [
{
"id": "NCT02369211_inc_text",
"type": "inclusion",
"text": [
"Patients undergoing robotic-assisted laparoscopic prostatectomy\n=18 years old males\nASA class 1-4\n"
],
"offsets": [
[
0,
98
]
]
}
] | [
{
"id": "NCT02369211_inc_T1",
"type": "Procedure",
"text": [
"obotic-assisted laparoscopic prostatectomy"
],
"offsets": [
[
21,
63
]
],
"normalized": []
},
{
"id": "NCT02369211_inc_T2",
"type": "Value",
"text": [
"=18 years old"
],
"offsets": [
[
64,
77
]
],
"normalized": []
},
{
"id": "NCT02369211_inc_T3",
"type": "Person",
"text": [
"males"
],
"offsets": [
[
78,
83
]
],
"normalized": []
},
{
"id": "NCT02369211_inc_T4",
"type": "Person",
"text": [
"years"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "NCT02369211_inc_T5",
"type": "Measurement",
"text": [
"ASA class"
],
"offsets": [
[
84,
93
]
],
"normalized": []
},
{
"id": "NCT02369211_inc_T6",
"type": "Value",
"text": [
"1-4"
],
"offsets": [
[
94,
97
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02369211_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02369211_inc_T4",
"arg2_id": "NCT02369211_inc_T2",
"normalized": []
},
{
"id": "NCT02369211_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02369211_inc_T5",
"arg2_id": "NCT02369211_inc_T6",
"normalized": []
}
] |
NCT02370069_exc | NCT02370069 | [
{
"id": "NCT02370069_exc_text",
"type": "exclusion",
"text": [
"immunization with PPV23 within the last year\nany confirmed or suspected immunodeficiency condition, including human immunodeficiency virus (HIV) infection, haematological malignancy, or a congenital immunodeficiency\nhistory of allergic disease or reactions likely to be exacerbated by any component of the vaccine\nhistory of allergic disease likely to be stimulated by the vaccination\nhistory or records of immunosuppressive therapy (with the exception of topical corticosteroids) for more than 14 days and within 6 months of vaccination\nhistory or evidence of administration of immunoglobulins and/or any blood products during the study period or within the three months preceding the study vaccine\nuse of any other investigational or non-registered drug or vaccine during the study period or within 30 days preceding the study vaccine\nadministration of a vaccine during the period starting one month before the dose of vaccine and ending one month after\npregnancy\n"
],
"offsets": [
[
0,
966
]
]
}
] | [
{
"id": "NCT02370069_exc_T1",
"type": "Procedure",
"text": [
"immunization"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T2",
"type": "Drug",
"text": [
"PPV23"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T3",
"type": "Temporal",
"text": [
"within the last year"
],
"offsets": [
[
24,
44
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T4",
"type": "Condition",
"text": [
"immunodeficiency condition"
],
"offsets": [
[
72,
98
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T5",
"type": "Qualifier",
"text": [
"suspected"
],
"offsets": [
[
62,
71
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T6",
"type": "Qualifier",
"text": [
"confirmed"
],
"offsets": [
[
49,
58
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T7",
"type": "Condition",
"text": [
"uman immunodeficiency virus",
"nfection,"
],
"offsets": [
[
111,
138
],
[
146,
155
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T8",
"type": "Condition",
"text": [
"HIV"
],
"offsets": [
[
140,
143
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T9",
"type": "Condition",
"text": [
"haematological malignancy"
],
"offsets": [
[
156,
181
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T10",
"type": "Condition",
"text": [
"congenital immunodeficiency"
],
"offsets": [
[
188,
215
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T11",
"type": "Scope",
"text": [
"human immunodeficiency virus (HIV) infection, haematological malignancy, or a congenital immunodeficiency"
],
"offsets": [
[
110,
215
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T12",
"type": "Scope",
"text": [
"confirmed or suspected"
],
"offsets": [
[
49,
71
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T13",
"type": "Condition",
"text": [
"allergic disease"
],
"offsets": [
[
227,
243
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T14",
"type": "Condition",
"text": [
"lergic d",
"actions l"
],
"offsets": [
[
229,
237
],
[
249,
258
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T15",
"type": "Scope",
"text": [
"allergic disease or reactions"
],
"offsets": [
[
227,
256
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T16",
"type": "Qualifier",
"text": [
"exacerbated by any component of the vaccine"
],
"offsets": [
[
270,
313
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T17",
"type": "Procedure",
"text": [
"vaccine"
],
"offsets": [
[
306,
313
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T18",
"type": "Condition",
"text": [
"allergic disease"
],
"offsets": [
[
325,
341
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T19",
"type": "Qualifier",
"text": [
"stimulated by the vaccination"
],
"offsets": [
[
355,
384
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T20",
"type": "Procedure",
"text": [
"vaccination"
],
"offsets": [
[
373,
384
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T21",
"type": "Procedure",
"text": [
"immunosuppressive therapy"
],
"offsets": [
[
407,
432
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T22",
"type": "Procedure",
"text": [
"topical corticosteroids"
],
"offsets": [
[
456,
479
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T23",
"type": "Negation",
"text": [
"exception"
],
"offsets": [
[
443,
452
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T24",
"type": "Temporal",
"text": [
"more than 14 days and",
"accination\nhis"
],
"offsets": [
[
485,
506
],
[
527,
541
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T25",
"type": "Temporal",
"text": [
"within 6 months of vaccination"
],
"offsets": [
[
507,
537
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T26",
"type": "Scope",
"text": [
"for more than 14 days and within 6 months of vaccination"
],
"offsets": [
[
481,
537
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T27",
"type": "Reference_point",
"text": [
"vaccination"
],
"offsets": [
[
526,
537
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T28",
"type": "Procedure",
"text": [
"immunoglobulins"
],
"offsets": [
[
579,
594
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T29",
"type": "Procedure",
"text": [
"blood products"
],
"offsets": [
[
606,
620
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T30",
"type": "Temporal",
"text": [
"during the study period"
],
"offsets": [
[
621,
644
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T31",
"type": "Temporal",
"text": [
"within the three months preceding the study vaccine"
],
"offsets": [
[
648,
699
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T32",
"type": "Reference_point",
"text": [
"study period"
],
"offsets": [
[
632,
644
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T33",
"type": "Reference_point",
"text": [
"study vaccine"
],
"offsets": [
[
686,
699
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T35",
"type": "Scope",
"text": [
"immunoglobulins and/or any blood products"
],
"offsets": [
[
579,
620
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T36",
"type": "Scope",
"text": [
"during the study period or within the three months preceding the study vaccine"
],
"offsets": [
[
621,
699
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T37",
"type": "Procedure",
"text": [
"vaccine"
],
"offsets": [
[
759,
766
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T38",
"type": "Procedure",
"text": [
"drug"
],
"offsets": [
[
751,
755
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T39",
"type": "Qualifier",
"text": [
"investigational"
],
"offsets": [
[
717,
732
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T40",
"type": "Qualifier",
"text": [
"non-registered"
],
"offsets": [
[
736,
750
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T41",
"type": "Scope",
"text": [
"drug or vaccine"
],
"offsets": [
[
751,
766
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T42",
"type": "Scope",
"text": [
"investigational or non-registered"
],
"offsets": [
[
717,
750
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T43",
"type": "Temporal",
"text": [
"during the study period"
],
"offsets": [
[
767,
790
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T44",
"type": "Temporal",
"text": [
"within 30 days preceding the study vaccine"
],
"offsets": [
[
794,
836
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T45",
"type": "Reference_point",
"text": [
"study period"
],
"offsets": [
[
778,
790
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T46",
"type": "Reference_point",
"text": [
"study vaccine"
],
"offsets": [
[
823,
836
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T47",
"type": "Scope",
"text": [
"during the study period or within 30 days preceding the study vaccine"
],
"offsets": [
[
767,
836
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T48",
"type": "Procedure",
"text": [
"vaccine"
],
"offsets": [
[
857,
864
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T49",
"type": "Temporal",
"text": [
"during the period starting one month before the dose of vaccine and ending one month after"
],
"offsets": [
[
865,
955
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T51",
"type": "Reference_point",
"text": [
"the dose of vaccine"
],
"offsets": [
[
909,
928
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T52",
"type": "Procedure",
"text": [
"vaccine"
],
"offsets": [
[
921,
928
]
],
"normalized": []
},
{
"id": "NCT02370069_exc_T50",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
956,
965
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02370069_exc_R1",
"type": "AND",
"arg1_id": "NCT02370069_exc_T1",
"arg2_id": "NCT02370069_exc_T2",
"normalized": []
},
{
"id": "NCT02370069_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02370069_exc_T7",
"arg2_id": "NCT02370069_exc_T8",
"normalized": []
},
{
"id": "NCT02370069_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02370069_exc_T4",
"arg2_id": "NCT02370069_exc_T11",
"normalized": []
},
{
"id": "NCT02370069_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T4",
"arg2_id": "NCT02370069_exc_T12",
"normalized": []
},
{
"id": "NCT02370069_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02370069_exc_T15",
"arg2_id": "NCT02370069_exc_T16",
"normalized": []
},
{
"id": "NCT02370069_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02370069_exc_T18",
"arg2_id": "NCT02370069_exc_T19",
"normalized": []
},
{
"id": "NCT02370069_exc_R9",
"type": "Has_negation",
"arg1_id": "NCT02370069_exc_T22",
"arg2_id": "NCT02370069_exc_T23",
"normalized": []
},
{
"id": "NCT02370069_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T21",
"arg2_id": "NCT02370069_exc_T26",
"normalized": []
},
{
"id": "NCT02370069_exc_R11",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T25",
"arg2_id": "NCT02370069_exc_T27",
"normalized": []
},
{
"id": "NCT02370069_exc_R12",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T24",
"arg2_id": "NCT02370069_exc_T27",
"normalized": []
},
{
"id": "NCT02370069_exc_R13",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T22",
"arg2_id": "NCT02370069_exc_T26",
"normalized": []
},
{
"id": "NCT02370069_exc_R14",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T30",
"arg2_id": "NCT02370069_exc_T32",
"normalized": []
},
{
"id": "NCT02370069_exc_R15",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T31",
"arg2_id": "NCT02370069_exc_T33",
"normalized": []
},
{
"id": "NCT02370069_exc_R16",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T35",
"arg2_id": "NCT02370069_exc_T36",
"normalized": []
},
{
"id": "NCT02370069_exc_R17",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T41",
"arg2_id": "NCT02370069_exc_T42",
"normalized": []
},
{
"id": "NCT02370069_exc_R18",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T43",
"arg2_id": "NCT02370069_exc_T45",
"normalized": []
},
{
"id": "NCT02370069_exc_R19",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T44",
"arg2_id": "NCT02370069_exc_T46",
"normalized": []
},
{
"id": "NCT02370069_exc_R20",
"type": "Has_scope",
"arg1_id": "NCT02370069_exc_T41",
"arg2_id": "NCT02370069_exc_T47",
"normalized": []
},
{
"id": "NCT02370069_exc_R21",
"type": "Has_index",
"arg1_id": "NCT02370069_exc_T49",
"arg2_id": "NCT02370069_exc_T51",
"normalized": []
}
] |
NCT02370069_inc | NCT02370069 | [
{
"id": "NCT02370069_inc_text",
"type": "inclusion",
"text": [
"Males and females of 18 years of age or older at the time of the vaccination\nSevere chronic kidney disease (Stage 4 and 5)\n"
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "NCT02370069_inc_T1",
"type": "Person",
"text": [
"Males"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T2",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
10,
17
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T3",
"type": "Value",
"text": [
"18 years",
"or older"
],
"offsets": [
[
21,
29
],
[
37,
45
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T5",
"type": "Temporal",
"text": [
"at the time of the vaccination"
],
"offsets": [
[
46,
76
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T6",
"type": "Reference_point",
"text": [
"vaccination"
],
"offsets": [
[
65,
76
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T7",
"type": "Procedure",
"text": [
"vaccination"
],
"offsets": [
[
65,
76
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T9",
"type": "Condition",
"text": [
"chronic kidney disease"
],
"offsets": [
[
84,
106
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T10",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
77,
83
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T11",
"type": "Condition",
"text": [
"tage 4",
"hronic kidney disease"
],
"offsets": [
[
109,
115
],
[
85,
106
]
],
"normalized": []
},
{
"id": "NCT02370069_inc_T12",
"type": "Condition",
"text": [
"tage",
")",
"hronic kidney disease"
],
"offsets": [
[
109,
113
],
[
121,
122
],
[
85,
106
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02370069_inc_R2",
"type": "Has_index",
"arg1_id": "NCT02370069_inc_T5",
"arg2_id": "NCT02370069_inc_T6",
"normalized": []
},
{
"id": "NCT02370069_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02370069_inc_T4",
"arg2_id": "NCT02370069_inc_T3",
"normalized": []
},
{
"id": "NCT02370069_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02370069_inc_T4",
"arg2_id": "NCT02370069_inc_T5",
"normalized": []
},
{
"id": "NCT02370069_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02370069_inc_T9",
"arg2_id": "NCT02370069_inc_T10",
"normalized": []
},
{
"id": "NCT02370069_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT02370069_inc_T9",
"arg2_id": "NCT02370069_inc_T11",
"normalized": []
},
{
"id": "NCT02370069_inc_R7",
"type": "Subsumes",
"arg1_id": "NCT02370069_inc_T9",
"arg2_id": "NCT02370069_inc_T12",
"normalized": []
}
] |
NCT02371200_exc | NCT02371200 | [
{
"id": "NCT02371200_exc_text",
"type": "exclusion",
"text": [
"1. Does not have a documented history of generalized seizures. \n2. Has not had a GTC seizure within the last year AND is not expected to have a reduction of anti-epileptic drugs during their hospital admission. \n3. Intracranial EEG electrodes are being used \n4. The subject's upper arm circumference not adequate for proper fit of the EMG monitor (less than 14cm). \n5. Pregnant female. \n6. Subject/Caregiver is unable to provide consent. \n \n"
],
"offsets": [
[
0,
450
]
]
}
] | [
{
"id": "NCT02371200_exc_T7",
"type": "Condition",
"text": [
"generalized seizures"
],
"offsets": [
[
41,
61
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T8",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
30,
37
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T9",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
8,
11
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T10",
"type": "Condition",
"text": [
"GTC seizure"
],
"offsets": [
[
81,
92
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T11",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
71,
74
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T12",
"type": "Temporal",
"text": [
"within the last year"
],
"offsets": [
[
93,
113
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T13",
"type": "Drug",
"text": [
"anti-epileptic drugs"
],
"offsets": [
[
157,
177
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T14",
"type": "Procedure",
"text": [
"reduction of anti-epileptic drugs"
],
"offsets": [
[
144,
177
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T15",
"type": "Temporal",
"text": [
"during their hospital admission"
],
"offsets": [
[
178,
209
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T16",
"type": "Reference_point",
"text": [
"hospital admission"
],
"offsets": [
[
191,
209
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T17",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
121,
124
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T18",
"type": "Device",
"text": [
"Intracranial EEG electrodes"
],
"offsets": [
[
215,
242
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T19",
"type": "Measurement",
"text": [
"upper arm circumference"
],
"offsets": [
[
276,
299
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T20",
"type": "Qualifier",
"text": [
"adequate for proper fit of the EMG monitor"
],
"offsets": [
[
304,
346
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T21",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
300,
303
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T23",
"type": "Value",
"text": [
"less than 14cm"
],
"offsets": [
[
348,
362
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T24",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
378,
384
]
],
"normalized": []
},
{
"id": "NCT02371200_exc_T25",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
369,
377
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02371200_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT02371200_exc_T7",
"arg2_id": "NCT02371200_exc_T9",
"normalized": []
},
{
"id": "NCT02371200_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02371200_exc_T7",
"arg2_id": "NCT02371200_exc_T8",
"normalized": []
},
{
"id": "NCT02371200_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02371200_exc_T10",
"arg2_id": "NCT02371200_exc_T12",
"normalized": []
},
{
"id": "NCT02371200_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02371200_exc_T10",
"arg2_id": "NCT02371200_exc_T11",
"normalized": []
},
{
"id": "NCT02371200_exc_R5",
"type": "AND",
"arg1_id": "NCT02371200_exc_T14",
"arg2_id": "NCT02371200_exc_T13",
"normalized": []
},
{
"id": "NCT02371200_exc_R6",
"type": "Has_index",
"arg1_id": "NCT02371200_exc_T15",
"arg2_id": "NCT02371200_exc_T16",
"normalized": []
},
{
"id": "NCT02371200_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02371200_exc_T14",
"arg2_id": "NCT02371200_exc_T15",
"normalized": []
},
{
"id": "NCT02371200_exc_R8",
"type": "Has_negation",
"arg1_id": "NCT02371200_exc_T14",
"arg2_id": "NCT02371200_exc_T17",
"normalized": []
},
{
"id": "NCT02371200_exc_R9",
"type": "Subsumes",
"arg1_id": "NCT02371200_exc_T20",
"arg2_id": "NCT02371200_exc_T23",
"normalized": []
},
{
"id": "NCT02371200_exc_R10",
"type": "Has_negation",
"arg1_id": "NCT02371200_exc_T20",
"arg2_id": "NCT02371200_exc_T21",
"normalized": []
},
{
"id": "NCT02371200_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT02371200_exc_T19",
"arg2_id": "NCT02371200_exc_T20",
"normalized": []
}
] |
NCT02371200_inc | NCT02371200 | [
{
"id": "NCT02371200_inc_text",
"type": "inclusion",
"text": [
"1. Subject has a history of GTC seizures, either primary GTC or partial onset seizures with secondary generalization. \n2. Is being admitted to a hospital for routine vEEG monitoring related to seizures. \n3. Male or female between the ages of 2-99. \n4. Has an upper arm circumference which is adequate for proper fit of the EMG monitor (at least 14cm). \n5. If female and of childbearing potential, has a negative pregnancy test. \n6. Can understand and sign written informed consent, or will have a parent or a legally authorized representative (LAR) who can do so, prior to the performance of any study assessments. \n7. Subject and/or Primary Caregiver must be competent to follow all study procedures. \n8. Is able to read, speak, and understand English. \n"
],
"offsets": [
[
0,
755
]
]
}
] | [
{
"id": "NCT02371200_inc_T9",
"type": "Condition",
"text": [
"GTC seizures"
],
"offsets": [
[
28,
40
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T10",
"type": "Condition",
"text": [
"primary GTC"
],
"offsets": [
[
49,
60
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T11",
"type": "Condition",
"text": [
"partial onset seizures"
],
"offsets": [
[
64,
86
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T12",
"type": "Condition",
"text": [
"secondary generalization"
],
"offsets": [
[
92,
116
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T13",
"type": "Scope",
"text": [
"primary GTC or partial onset seizures with secondary generalization"
],
"offsets": [
[
49,
116
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T14",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
17,
24
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T15",
"type": "Procedure",
"text": [
"vEEG monitoring"
],
"offsets": [
[
166,
181
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T16",
"type": "Condition",
"text": [
"seizures"
],
"offsets": [
[
193,
201
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T17",
"type": "Procedure",
"text": [
"admitted to a hospital"
],
"offsets": [
[
131,
153
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T18",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
215,
221
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T19",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T21",
"type": "Person",
"text": [
"the ages"
],
"offsets": [
[
230,
238
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T20",
"type": "Value",
"text": [
"between",
"2-99"
],
"offsets": [
[
222,
229
],
[
242,
246
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T22",
"type": "Measurement",
"text": [
"upper arm circumference"
],
"offsets": [
[
259,
282
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T23",
"type": "Qualifier",
"text": [
"adequate for proper fit of the EMG monitor"
],
"offsets": [
[
292,
334
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T25",
"type": "Value",
"text": [
"at least 14cm"
],
"offsets": [
[
336,
349
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T26",
"type": "Condition",
"text": [
"childbearing potential"
],
"offsets": [
[
373,
395
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T27",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
359,
365
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T28",
"type": "Scope",
"text": [
"female and of childbearing potential"
],
"offsets": [
[
359,
395
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T29",
"type": "Measurement",
"text": [
"pregnancy test"
],
"offsets": [
[
412,
426
]
],
"normalized": []
},
{
"id": "NCT02371200_inc_T30",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
403,
411
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02371200_inc_R1",
"type": "AND",
"arg1_id": "NCT02371200_inc_T11",
"arg2_id": "NCT02371200_inc_T12",
"normalized": []
},
{
"id": "NCT02371200_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02371200_inc_T9",
"arg2_id": "NCT02371200_inc_T13",
"normalized": []
},
{
"id": "NCT02371200_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02371200_inc_T9",
"arg2_id": "NCT02371200_inc_T14",
"normalized": []
},
{
"id": "NCT02371200_inc_R4",
"type": "AND",
"arg1_id": "NCT02371200_inc_T15",
"arg2_id": "NCT02371200_inc_T16",
"normalized": []
},
{
"id": "NCT02371200_inc_R5",
"type": "AND",
"arg1_id": "NCT02371200_inc_T17",
"arg2_id": "NCT02371200_inc_T15",
"normalized": []
},
{
"id": "NCT02371200_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02371200_inc_T21",
"arg2_id": "NCT02371200_inc_T20",
"normalized": []
},
{
"id": "NCT02371200_inc_R7",
"type": "Subsumes",
"arg1_id": "NCT02371200_inc_T23",
"arg2_id": "NCT02371200_inc_T25",
"normalized": []
},
{
"id": "NCT02371200_inc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02371200_inc_T22",
"arg2_id": "NCT02371200_inc_T23",
"normalized": []
},
{
"id": "NCT02371200_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02371200_inc_T29",
"arg2_id": "NCT02371200_inc_T30",
"normalized": []
},
{
"id": "NCT02371200_inc_R10",
"type": "AND",
"arg1_id": "NCT02371200_inc_T28",
"arg2_id": "NCT02371200_inc_T29",
"normalized": []
}
] |
NCT02375295_exc | NCT02375295 | [
{
"id": "NCT02375295_exc_text",
"type": "exclusion",
"text": [
"Patients with medical comorbidities preventing them from definitive surgical therapy.\nPatients with persistent stone burden following definitive surgical therapy.\n"
],
"offsets": [
[
0,
163
]
]
}
] | [
{
"id": "NCT02375295_exc_T1",
"type": "Condition",
"text": [
"medical comorbidities"
],
"offsets": [
[
14,
35
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T2",
"type": "Procedure",
"text": [
"definitive surgical therapy"
],
"offsets": [
[
57,
84
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T3",
"type": "Mood",
"text": [
"preventing them from"
],
"offsets": [
[
36,
56
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T4",
"type": "Qualifier",
"text": [
"persistent"
],
"offsets": [
[
100,
110
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T5",
"type": "Observation",
"text": [
"stone burden"
],
"offsets": [
[
111,
123
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T6",
"type": "Temporal",
"text": [
"following definitive surgical therapy"
],
"offsets": [
[
124,
161
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T7",
"type": "Reference_point",
"text": [
"definitive surgical therapy"
],
"offsets": [
[
134,
161
]
],
"normalized": []
},
{
"id": "NCT02375295_exc_T8",
"type": "Procedure",
"text": [
"definitive surgical therapy"
],
"offsets": [
[
134,
161
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02375295_exc_R1",
"type": "Has_mood",
"arg1_id": "NCT02375295_exc_T2",
"arg2_id": "NCT02375295_exc_T3",
"normalized": []
},
{
"id": "NCT02375295_exc_R2",
"type": "AND",
"arg1_id": "NCT02375295_exc_T1",
"arg2_id": "NCT02375295_exc_T2",
"normalized": []
},
{
"id": "NCT02375295_exc_R4",
"type": "AND",
"arg1_id": "NCT02375295_exc_T6",
"arg2_id": "NCT02375295_exc_T8",
"normalized": []
},
{
"id": "NCT02375295_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02375295_exc_T5",
"arg2_id": "NCT02375295_exc_T4",
"normalized": []
},
{
"id": "NCT02375295_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02375295_exc_T5",
"arg2_id": "NCT02375295_exc_T6",
"normalized": []
}
] |
NCT02375295_inc | NCT02375295 | [
{
"id": "NCT02375295_inc_text",
"type": "inclusion",
"text": [
"Male or Female.\nNo age restriction.\nDiagnosed with an infection related stone.\nMedically fit for definitive surgical management of stone.\nLife expectancy greater than one year.\nStone free after definitive surgical therapy defined as fragments less than 3mm.\n"
],
"offsets": [
[
0,
258
]
]
}
] | [
{
"id": "NCT02375295_inc_T1",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T2",
"type": "Person",
"text": [
"Female"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T3",
"type": "Qualifier",
"text": [
"infection related"
],
"offsets": [
[
54,
71
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T4",
"type": "Condition",
"text": [
"stone"
],
"offsets": [
[
72,
77
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T5",
"type": "Mood",
"text": [
"Medically fit for"
],
"offsets": [
[
79,
96
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T6",
"type": "Procedure",
"text": [
"definitive surgical management"
],
"offsets": [
[
97,
127
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T7",
"type": "Condition",
"text": [
"stone"
],
"offsets": [
[
131,
136
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T8",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
138,
153
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T9",
"type": "Value",
"text": [
"greater than one year"
],
"offsets": [
[
154,
175
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T10",
"type": "Condition",
"text": [
"Stone"
],
"offsets": [
[
177,
182
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T11",
"type": "Negation",
"text": [
"free"
],
"offsets": [
[
183,
187
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T12",
"type": "Temporal",
"text": [
"after definitive surgical therapy"
],
"offsets": [
[
188,
221
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T13",
"type": "Reference_point",
"text": [
"definitive surgical therapy"
],
"offsets": [
[
194,
221
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T14",
"type": "Procedure",
"text": [
"definitive surgical therapy"
],
"offsets": [
[
194,
221
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T15",
"type": "Scope",
"text": [
"Stone free"
],
"offsets": [
[
177,
187
]
],
"normalized": []
},
{
"id": "NCT02375295_inc_T16",
"type": "Qualifier",
"text": [
"fragments less than 3mm"
],
"offsets": [
[
233,
256
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02375295_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02375295_inc_T4",
"arg2_id": "NCT02375295_inc_T3",
"normalized": []
},
{
"id": "NCT02375295_inc_R2",
"type": "AND",
"arg1_id": "NCT02375295_inc_T6",
"arg2_id": "NCT02375295_inc_T7",
"normalized": []
},
{
"id": "NCT02375295_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT02375295_inc_T6",
"arg2_id": "NCT02375295_inc_T5",
"normalized": []
},
{
"id": "NCT02375295_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02375295_inc_T8",
"arg2_id": "NCT02375295_inc_T9",
"normalized": []
},
{
"id": "NCT02375295_inc_R5",
"type": "Has_negation",
"arg1_id": "NCT02375295_inc_T10",
"arg2_id": "NCT02375295_inc_T11",
"normalized": []
},
{
"id": "NCT02375295_inc_R6",
"type": "Has_index",
"arg1_id": "NCT02375295_inc_T12",
"arg2_id": "NCT02375295_inc_T13",
"normalized": []
},
{
"id": "NCT02375295_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02375295_inc_T15",
"arg2_id": "NCT02375295_inc_T12",
"normalized": []
},
{
"id": "NCT02375295_inc_R9",
"type": "Subsumes",
"arg1_id": "NCT02375295_inc_T15",
"arg2_id": "NCT02375295_inc_T16",
"normalized": []
}
] |
NCT02379156_exc | NCT02379156 | [
{
"id": "NCT02379156_exc_text",
"type": "exclusion",
"text": [
"Evidence of sympathetic integrity below the lesion level by the skin axon-reflex vasodilatation (SkARV) test;\nKnown allergies to midodrine hydrochloride;\nPMH of diagnosed heart, kidney, peripheral vascular, or cerebral vascular disease, or diabetes mellitus;\nHypertension (BP>140/90 mmHg);\nUntreated thyroid disease;\nAcute illness or infection;\nCurrent smoker;\nPregnancy.\n"
],
"offsets": [
[
0,
372
]
]
}
] | [
{
"id": "NCT02379156_exc_T1",
"type": "Observation",
"text": [
"sympathetic integrity"
],
"offsets": [
[
12,
33
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T2",
"type": "Qualifier",
"text": [
"below the lesion level"
],
"offsets": [
[
34,
56
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T3",
"type": "Measurement",
"text": [
"test",
"skin axon-reflex vasodilatation"
],
"offsets": [
[
104,
108
],
[
64,
95
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T4",
"type": "Measurement",
"text": [
"SkARV"
],
"offsets": [
[
97,
102
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T5",
"type": "Condition",
"text": [
"allergies"
],
"offsets": [
[
116,
125
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T6",
"type": "Drug",
"text": [
"midodrine hydrochloride"
],
"offsets": [
[
129,
152
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T7",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
240,
257
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T8",
"type": "Condition",
"text": [
"cerebral vascular disease"
],
"offsets": [
[
210,
235
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T9",
"type": "Condition",
"text": [
"ripheral vascular, o",
"sease,"
],
"offsets": [
[
188,
208
],
[
230,
236
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T10",
"type": "Condition",
"text": [
"dney,",
"sease,"
],
"offsets": [
[
180,
185
],
[
230,
236
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T11",
"type": "Condition",
"text": [
"art,",
"sease,"
],
"offsets": [
[
173,
177
],
[
230,
236
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T12",
"type": "Condition",
"text": [
"Hypertension"
],
"offsets": [
[
259,
271
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T13",
"type": "Measurement",
"text": [
"BP"
],
"offsets": [
[
273,
275
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T14",
"type": "Value",
"text": [
">140/90 mmHg"
],
"offsets": [
[
275,
287
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T15",
"type": "Condition",
"text": [
"thyroid disease"
],
"offsets": [
[
300,
315
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T16",
"type": "Qualifier",
"text": [
"Untreated"
],
"offsets": [
[
290,
299
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T17",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
334,
343
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T18",
"type": "Condition",
"text": [
"illness"
],
"offsets": [
[
323,
330
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T19",
"type": "Qualifier",
"text": [
"Acute"
],
"offsets": [
[
317,
322
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T20",
"type": "Scope",
"text": [
"illness or infection"
],
"offsets": [
[
323,
343
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T21",
"type": "Person",
"text": [
"smoker"
],
"offsets": [
[
353,
359
]
],
"normalized": []
},
{
"id": "NCT02379156_exc_T22",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
361,
370
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02379156_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02379156_exc_T1",
"arg2_id": "NCT02379156_exc_T2",
"normalized": []
},
{
"id": "NCT02379156_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02379156_exc_T3",
"arg2_id": "NCT02379156_exc_T4",
"normalized": []
},
{
"id": "NCT02379156_exc_R4",
"type": "AND",
"arg1_id": "NCT02379156_exc_T5",
"arg2_id": "NCT02379156_exc_T6",
"normalized": []
},
{
"id": "NCT02379156_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02379156_exc_T13",
"arg2_id": "NCT02379156_exc_T14",
"normalized": []
},
{
"id": "NCT02379156_exc_R6",
"type": "AND",
"arg1_id": "NCT02379156_exc_T12",
"arg2_id": "NCT02379156_exc_T13",
"normalized": []
},
{
"id": "NCT02379156_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02379156_exc_T15",
"arg2_id": "NCT02379156_exc_T16",
"normalized": []
},
{
"id": "NCT02379156_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02379156_exc_T20",
"arg2_id": "NCT02379156_exc_T19",
"normalized": []
}
] |
NCT02379156_inc | NCT02379156 | [
{
"id": "NCT02379156_inc_text",
"type": "inclusion",
"text": [
"Duration of SCI =1 year;\nLevel of SCI C3-T1, AIS A & B;\nAge between 18 and 65 years.\n"
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "NCT02379156_inc_T1",
"type": "Condition",
"text": [
"SCI"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T2",
"type": "Temporal",
"text": [
"=1 year"
],
"offsets": [
[
16,
23
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T3",
"type": "Measurement",
"text": [
"Level of SCI"
],
"offsets": [
[
25,
37
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T4",
"type": "Value",
"text": [
"C3-T1"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T5",
"type": "Measurement",
"text": [
"AIS"
],
"offsets": [
[
45,
48
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T6",
"type": "Value",
"text": [
"A & B"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T7",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "NCT02379156_inc_T8",
"type": "Value",
"text": [
"between 18 and 65 years"
],
"offsets": [
[
60,
83
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02379156_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02379156_inc_T1",
"arg2_id": "NCT02379156_inc_T2",
"normalized": []
},
{
"id": "NCT02379156_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02379156_inc_T3",
"arg2_id": "NCT02379156_inc_T4",
"normalized": []
},
{
"id": "NCT02379156_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02379156_inc_T5",
"arg2_id": "NCT02379156_inc_T6",
"normalized": []
},
{
"id": "NCT02379156_inc_R4",
"type": "Has_value",
"arg1_id": "NCT02379156_inc_T7",
"arg2_id": "NCT02379156_inc_T8",
"normalized": []
}
] |
NCT02380118_exc | NCT02380118 | [
{
"id": "NCT02380118_exc_text",
"type": "exclusion",
"text": [
"known hypersensitivity or contraindication to the study drugs\nreversible aetiology for agitation (e.g. hypotension, hypoxia, hypoglycaemia)\nknown pregnancy\nacute alcohol withdrawal\npatients aged>75 years.\n"
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "NCT02380118_exc_T1",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
6,
22
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T2",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
26,
42
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T3",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
50,
61
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T4",
"type": "Scope",
"text": [
"hypersensitivity or contraindication"
],
"offsets": [
[
6,
42
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T5",
"type": "Condition",
"text": [
"reversible aetiology"
],
"offsets": [
[
62,
82
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T6",
"type": "Condition",
"text": [
"agitation"
],
"offsets": [
[
87,
96
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T7",
"type": "Condition",
"text": [
"hypotension"
],
"offsets": [
[
103,
114
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T8",
"type": "Condition",
"text": [
"hypoxia"
],
"offsets": [
[
116,
123
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T9",
"type": "Condition",
"text": [
"hypoglycaemia"
],
"offsets": [
[
125,
138
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T10",
"type": "Scope",
"text": [
"hypotension, hypoxia, hypoglycaemia"
],
"offsets": [
[
103,
138
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T11",
"type": "Scope",
"text": [
"reversible aetiology for agitation"
],
"offsets": [
[
62,
96
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T12",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
146,
155
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T13",
"type": "Condition",
"text": [
"acute alcohol withdrawal"
],
"offsets": [
[
156,
180
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T14",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
190,
194
]
],
"normalized": []
},
{
"id": "NCT02380118_exc_T15",
"type": "Value",
"text": [
">75 years"
],
"offsets": [
[
194,
203
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02380118_exc_R1",
"type": "AND",
"arg1_id": "NCT02380118_exc_T4",
"arg2_id": "NCT02380118_exc_T3",
"normalized": []
},
{
"id": "NCT02380118_exc_R2",
"type": "AND",
"arg1_id": "NCT02380118_exc_T5",
"arg2_id": "NCT02380118_exc_T6",
"normalized": []
},
{
"id": "NCT02380118_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT02380118_exc_T11",
"arg2_id": "NCT02380118_exc_T10",
"normalized": []
},
{
"id": "NCT02380118_exc_R4",
"type": "Has_value",
"arg1_id": "NCT02380118_exc_T14",
"arg2_id": "NCT02380118_exc_T15",
"normalized": []
}
] |
NCT02380118_inc | NCT02380118 | [
{
"id": "NCT02380118_inc_text",
"type": "inclusion",
"text": [
"Accident & Emergency Department patients, requiring parenteral drug sedation (as determined by an emergency clinician) will be enrolled.\n"
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "NCT02380118_inc_T1",
"type": "Visit",
"text": [
"Accident & Emergency Department"
],
"offsets": [
[
0,
31
]
],
"normalized": []
},
{
"id": "NCT02380118_inc_T2",
"type": "Procedure",
"text": [
"parenteral drug sedation"
],
"offsets": [
[
52,
76
]
],
"normalized": []
},
{
"id": "NCT02380118_inc_T3",
"type": "Mood",
"text": [
"requiring"
],
"offsets": [
[
42,
51
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02380118_inc_R1",
"type": "Has_mood",
"arg1_id": "NCT02380118_inc_T2",
"arg2_id": "NCT02380118_inc_T3",
"normalized": []
}
] |
NCT02384850_exc | NCT02384850 | [
{
"id": "NCT02384850_exc_text",
"type": "exclusion",
"text": [
"adequately controlled with appropriate therapy or would compromise the patient's ability to tolerate this therapy; 2. Treatment with any systemic anticancer therapy ≤ 3 weeks prior to cycle 1 day 1 3. Uncontrolled active infection (Hepatitis B and C infection are NOT exclusion criteria) and/or known HIV infection; 4. Renal failure requiring haemodialysis or peritoneal dialysis; 5. Patients who are pregnant or breast-feeding; 6. Patients with significantly diseased or obstructed gastrointestinal tract, malabsorption, uncontrolled vomiting or diarrhea resulting in inability to swallow oral medications; 7. Presence of symptomatic CNS metastasis 8. Unresolved toxicity from previous anti-cancer therapy or incomplete recovery from surgery, in particular oxaliplatin-induced peripheral neuropathy > grade 1. \n9. Any of the following within the 12 months prior to study drug administration: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis, or other thromboembolic event. \n \n"
],
"offsets": [
[
0,
1159
]
]
}
] | [
{
"id": "NCT02384850_exc_T3",
"type": "Procedure",
"text": [
"systemic anticancer therapy"
],
"offsets": [
[
137,
164
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T4",
"type": "Temporal",
"text": [
"≤ 3 weeks prior to cycle 1"
],
"offsets": [
[
165,
191
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T5",
"type": "Reference_point",
"text": [
"cycle 1"
],
"offsets": [
[
184,
191
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T6",
"type": "Condition",
"text": [
"Hepatitis B",
"infection"
],
"offsets": [
[
232,
243
],
[
250,
259
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T7",
"type": "Condition",
"text": [
"Hepatitis",
"C infection"
],
"offsets": [
[
232,
241
],
[
248,
259
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T8",
"type": "Negation",
"text": [
"NOT"
],
"offsets": [
[
264,
267
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T9",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
221,
230
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T10",
"type": "Temporal",
"text": [
"active"
],
"offsets": [
[
214,
220
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T11",
"type": "Qualifier",
"text": [
"Uncontrolled"
],
"offsets": [
[
201,
213
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T12",
"type": "Scope",
"text": [
"Hepatitis B and C infection are NOT exclusion criteria"
],
"offsets": [
[
232,
286
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T13",
"type": "Condition",
"text": [
"HIV infection"
],
"offsets": [
[
301,
314
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T14",
"type": "Condition",
"text": [
"Renal failure"
],
"offsets": [
[
319,
332
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T15",
"type": "Procedure",
"text": [
"haemodialysis"
],
"offsets": [
[
343,
356
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T16",
"type": "Procedure",
"text": [
"peritoneal dialysis"
],
"offsets": [
[
360,
379
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T17",
"type": "Scope",
"text": [
"haemodialysis or peritoneal dialysis"
],
"offsets": [
[
343,
379
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T18",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
401,
409
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T19",
"type": "Condition",
"text": [
"breast-feeding"
],
"offsets": [
[
413,
427
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T22",
"type": "Condition",
"text": [
"obstructed gastrointestinal tract"
],
"offsets": [
[
472,
505
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T23",
"type": "Condition",
"text": [
"diseased",
"gastrointestinal tract"
],
"offsets": [
[
460,
468
],
[
483,
505
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T25",
"type": "Qualifier",
"text": [
"significantly"
],
"offsets": [
[
446,
459
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T28",
"type": "Condition",
"text": [
"malabsorption"
],
"offsets": [
[
507,
520
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T29",
"type": "Condition",
"text": [
"vomiting"
],
"offsets": [
[
535,
543
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T30",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
522,
534
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T31",
"type": "Condition",
"text": [
"diarrhea"
],
"offsets": [
[
547,
555
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T32",
"type": "Condition",
"text": [
"inability to swallow oral medications"
],
"offsets": [
[
569,
606
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T34",
"type": "Condition",
"text": [
"CNS metastasis"
],
"offsets": [
[
635,
649
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T36",
"type": "Qualifier",
"text": [
"symptomatic"
],
"offsets": [
[
623,
634
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T37",
"type": "Procedure",
"text": [
"anti-cancer therapy"
],
"offsets": [
[
687,
706
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T38",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
678,
686
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T39",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
735,
742
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T40",
"type": "Condition",
"text": [
"incomplete recovery"
],
"offsets": [
[
710,
729
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T41",
"type": "Drug",
"text": [
"oxaliplatin"
],
"offsets": [
[
758,
769
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T42",
"type": "Qualifier",
"text": [
"oxaliplatin-induced"
],
"offsets": [
[
758,
777
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T43",
"type": "Condition",
"text": [
"peripheral neuropathy"
],
"offsets": [
[
778,
799
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T44",
"type": "Condition",
"text": [
"Unresolved toxicity"
],
"offsets": [
[
653,
672
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T46",
"type": "Temporal",
"text": [
"within the 12 months prior to study drug administration"
],
"offsets": [
[
836,
891
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T47",
"type": "Reference_point",
"text": [
"study drug administration"
],
"offsets": [
[
866,
891
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T48",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
893,
914
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T49",
"type": "Condition",
"text": [
"unstable angina"
],
"offsets": [
[
923,
938
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T50",
"type": "Condition",
"text": [
"severe",
"angina"
],
"offsets": [
[
916,
922
],
[
932,
938
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T51",
"type": "Condition",
"text": [
"coronary",
"artery bypass graft"
],
"offsets": [
[
940,
948
],
[
960,
979
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T52",
"type": "Condition",
"text": [
"peripheral artery bypass graft"
],
"offsets": [
[
949,
979
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T53",
"type": "Condition",
"text": [
"symptomatic congestive heart failure"
],
"offsets": [
[
981,
1017
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T54",
"type": "Condition",
"text": [
"cerebrovascular accident"
],
"offsets": [
[
1019,
1043
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T55",
"type": "Condition",
"text": [
"transient ischemic attack"
],
"offsets": [
[
1047,
1072
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T56",
"type": "Condition",
"text": [
"pulmonary embolism"
],
"offsets": [
[
1074,
1092
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T57",
"type": "Condition",
"text": [
"deep vein thrombosis"
],
"offsets": [
[
1094,
1114
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T58",
"type": "Condition",
"text": [
"other thromboembolic event"
],
"offsets": [
[
1119,
1145
]
],
"normalized": []
},
{
"id": "NCT02384850_exc_T59",
"type": "Scope",
"text": [
"myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis, or other thromboembolic event"
],
"offsets": [
[
893,
1145
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02384850_exc_R1",
"type": "Has_index",
"arg1_id": "NCT02384850_exc_T4",
"arg2_id": "NCT02384850_exc_T5",
"normalized": []
},
{
"id": "NCT02384850_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02384850_exc_T3",
"arg2_id": "NCT02384850_exc_T4",
"normalized": []
},
{
"id": "NCT02384850_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02384850_exc_T6",
"arg2_id": "NCT02384850_exc_T8",
"normalized": []
},
{
"id": "NCT02384850_exc_R4",
"type": "Has_negation",
"arg1_id": "NCT02384850_exc_T7",
"arg2_id": "NCT02384850_exc_T8",
"normalized": []
},
{
"id": "NCT02384850_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_exc_T9",
"arg2_id": "NCT02384850_exc_T11",
"normalized": []
},
{
"id": "NCT02384850_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02384850_exc_T9",
"arg2_id": "NCT02384850_exc_T10",
"normalized": []
},
{
"id": "NCT02384850_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT02384850_exc_T9",
"arg2_id": "NCT02384850_exc_T12",
"normalized": []
},
{
"id": "NCT02384850_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT02384850_exc_T14",
"arg2_id": "NCT02384850_exc_T17",
"normalized": []
},
{
"id": "NCT02384850_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_exc_T29",
"arg2_id": "NCT02384850_exc_T30",
"normalized": []
},
{
"id": "NCT02384850_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_exc_T34",
"arg2_id": "NCT02384850_exc_T36",
"normalized": []
},
{
"id": "NCT02384850_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT02384850_exc_T37",
"arg2_id": "NCT02384850_exc_T38",
"normalized": []
},
{
"id": "NCT02384850_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_exc_T43",
"arg2_id": "NCT02384850_exc_T42",
"normalized": []
},
{
"id": "NCT02384850_exc_R13",
"type": "AND",
"arg1_id": "NCT02384850_exc_T40",
"arg2_id": "NCT02384850_exc_T39",
"normalized": []
},
{
"id": "NCT02384850_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT02384850_exc_T40",
"arg2_id": "NCT02384850_exc_T43",
"normalized": []
},
{
"id": "NCT02384850_exc_R15",
"type": "AND",
"arg1_id": "NCT02384850_exc_T44",
"arg2_id": "NCT02384850_exc_T37",
"normalized": []
},
{
"id": "NCT02384850_exc_R16",
"type": "Has_temporal",
"arg1_id": "NCT02384850_exc_T59",
"arg2_id": "NCT02384850_exc_T46",
"normalized": []
}
] |
NCT02384850_inc | NCT02384850 | [
{
"id": "NCT02384850_inc_text",
"type": "inclusion",
"text": [
"1. Patients with histologically confirmed diagnosis of colorectal cancer presenting with unresectable stage IV (UICC) disease (primary tumor may be present) \n2. Patients who are feasible for treatment with FOLFOX (prior adjuvant or palliative treatment is allowed) \n3. ECOG Performance status ≤ 1 \n4. Life expectancy > 3 months \n5. Age ≥18 years \n6. Haematologic function as follows (5% deviation allowed): \nANC ≥ 1.5 x 109/L \nplatelets ≥ 100 x109/L \nhemoglobin ≥ 9 g/dl or 5.59 mmol/l \n7. Adequate liver function as follows (10% deviation allowed) \nserum alanine transaminase (ALT) ≤ 2.5 x ULN (in case of liver metastases < 5 x ULN) \ntotal bilirubin ≤ 1.5 x ULN (patients with Gilbert's syndrome total bilirubin ≤2.5 x ULN) \n8. Adequate renal function as follows (10% deviation allowed) \n· creatinine ≤ 1.5 x ULN \n9. Signed written informed consent \n10. Women of child-bearing potential must have a negative pregnancy test \n"
],
"offsets": [
[
0,
926
]
]
}
] | [
{
"id": "NCT02384850_inc_T11",
"type": "Condition",
"text": [
"colorectal cancer"
],
"offsets": [
[
55,
72
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T12",
"type": "Qualifier",
"text": [
"unresectable"
],
"offsets": [
[
89,
101
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T13",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
118,
125
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T15",
"type": "Qualifier",
"text": [
"stage IV (UICC)"
],
"offsets": [
[
102,
117
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T16",
"type": "Value",
"text": [
"IV"
],
"offsets": [
[
108,
110
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T17",
"type": "Procedure",
"text": [
"histologically"
],
"offsets": [
[
17,
31
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T18",
"type": "Value",
"text": [
"confirmed"
],
"offsets": [
[
32,
41
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T19",
"type": "Drug",
"text": [
"FOLFOX"
],
"offsets": [
[
206,
212
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T21",
"type": "Procedure",
"text": [
"palliative treatment"
],
"offsets": [
[
232,
252
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T22",
"type": "Procedure",
"text": [
"adjuvant",
"treatment"
],
"offsets": [
[
220,
228
],
[
243,
252
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T24",
"type": "Measurement",
"text": [
"ECOG Performance status"
],
"offsets": [
[
269,
292
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T25",
"type": "Value",
"text": [
"≤ 1"
],
"offsets": [
[
293,
296
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T26",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
301,
316
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T27",
"type": "Value",
"text": [
"> 3 months"
],
"offsets": [
[
317,
327
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T28",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
332,
335
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T29",
"type": "Value",
"text": [
"≥18 years"
],
"offsets": [
[
336,
345
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T31",
"type": "Measurement",
"text": [
"ANC"
],
"offsets": [
[
408,
411
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T32",
"type": "Value",
"text": [
"≥ 1.5 x 109/L"
],
"offsets": [
[
412,
425
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T33",
"type": "Measurement",
"text": [
"platelets"
],
"offsets": [
[
427,
436
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T34",
"type": "Value",
"text": [
"≥ 100 x109/L"
],
"offsets": [
[
437,
449
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T35",
"type": "Measurement",
"text": [
"hemoglobin"
],
"offsets": [
[
451,
461
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T36",
"type": "Value",
"text": [
"≥ 9 g/dl"
],
"offsets": [
[
462,
470
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T37",
"type": "Value",
"text": [
"≥",
"5.59 mmol/l"
],
"offsets": [
[
462,
463
],
[
474,
485
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T38",
"type": "Scope",
"text": [
"≥ 9 g/dl or 5.59 mmol/l"
],
"offsets": [
[
462,
485
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T39",
"type": "Measurement",
"text": [
"liver function"
],
"offsets": [
[
499,
513
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T40",
"type": "Value",
"text": [
"Adequate"
],
"offsets": [
[
490,
498
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T42",
"type": "Measurement",
"text": [
"serum alanine transaminase (ALT)"
],
"offsets": [
[
550,
582
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T43",
"type": "Value",
"text": [
"≤ 2.5 x ULN"
],
"offsets": [
[
583,
594
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T44",
"type": "Condition",
"text": [
"liver metastases"
],
"offsets": [
[
607,
623
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T45",
"type": "Value",
"text": [
"< 5 x ULN"
],
"offsets": [
[
624,
633
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T46",
"type": "Measurement",
"text": [
"total bilirubin"
],
"offsets": [
[
636,
651
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T47",
"type": "Value",
"text": [
"≤ 1.5 x ULN"
],
"offsets": [
[
652,
663
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T48",
"type": "Condition",
"text": [
"Gilbert's syndrome"
],
"offsets": [
[
679,
697
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T49",
"type": "Measurement",
"text": [
"total bilirubin"
],
"offsets": [
[
698,
713
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T50",
"type": "Value",
"text": [
"≤2.5 x ULN"
],
"offsets": [
[
714,
724
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T51",
"type": "Measurement",
"text": [
"renal function"
],
"offsets": [
[
739,
753
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T52",
"type": "Value",
"text": [
"Adequate"
],
"offsets": [
[
730,
738
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T54",
"type": "Measurement",
"text": [
"creatinine"
],
"offsets": [
[
792,
802
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T55",
"type": "Value",
"text": [
"≤ 1.5 x ULN"
],
"offsets": [
[
803,
814
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T57",
"type": "Condition",
"text": [
"child-bearing potential"
],
"offsets": [
[
865,
888
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T58",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
856,
861
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T59",
"type": "Measurement",
"text": [
"pregnancy test"
],
"offsets": [
[
910,
924
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T60",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
901,
909
]
],
"normalized": []
},
{
"id": "NCT02384850_inc_T61",
"type": "Scope",
"text": [
"Women of child-bearing potential"
],
"offsets": [
[
856,
888
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02384850_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02384850_inc_T13",
"arg2_id": "NCT02384850_inc_T11",
"normalized": []
},
{
"id": "NCT02384850_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_inc_T13",
"arg2_id": "NCT02384850_inc_T15",
"normalized": []
},
{
"id": "NCT02384850_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02384850_inc_T13",
"arg2_id": "NCT02384850_inc_T12",
"normalized": []
},
{
"id": "NCT02384850_inc_R4",
"type": "AND",
"arg1_id": "NCT02384850_inc_T11",
"arg2_id": "NCT02384850_inc_T17",
"normalized": []
},
{
"id": "NCT02384850_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T26",
"arg2_id": "NCT02384850_inc_T27",
"normalized": []
},
{
"id": "NCT02384850_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T28",
"arg2_id": "NCT02384850_inc_T29",
"normalized": []
},
{
"id": "NCT02384850_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT02384850_inc_T35",
"arg2_id": "NCT02384850_inc_T38",
"normalized": []
},
{
"id": "NCT02384850_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T39",
"arg2_id": "NCT02384850_inc_T40",
"normalized": []
},
{
"id": "NCT02384850_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T42",
"arg2_id": "NCT02384850_inc_T43",
"normalized": []
},
{
"id": "NCT02384850_inc_R10",
"type": "Subsumes",
"arg1_id": "NCT02384850_inc_T43",
"arg2_id": "NCT02384850_inc_T44",
"normalized": []
},
{
"id": "NCT02384850_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T44",
"arg2_id": "NCT02384850_inc_T45",
"normalized": []
},
{
"id": "NCT02384850_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T46",
"arg2_id": "NCT02384850_inc_T47",
"normalized": []
},
{
"id": "NCT02384850_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T51",
"arg2_id": "NCT02384850_inc_T52",
"normalized": []
},
{
"id": "NCT02384850_inc_R14",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T54",
"arg2_id": "NCT02384850_inc_T55",
"normalized": []
},
{
"id": "NCT02384850_inc_R15",
"type": "AND",
"arg1_id": "NCT02384850_inc_T61",
"arg2_id": "NCT02384850_inc_T59",
"normalized": []
},
{
"id": "NCT02384850_inc_R16",
"type": "Has_value",
"arg1_id": "NCT02384850_inc_T59",
"arg2_id": "NCT02384850_inc_T60",
"normalized": []
}
] |
NCT02385045_exc | NCT02385045 | [
{
"id": "NCT02385045_exc_text",
"type": "exclusion",
"text": [
"Patients attending for a therapeutic endoscopic procedure e.g. variceal banding, stent insertion, balloon dilatation. \nPatients with a known diagnosis e.g. upper gastrointestinal cancer \nPatients previously treated with HP eradication therapy \nPatients who had taken PPI, H2 receptor antagonists and antibiotics within 4 weeks \nPatients with acute gastrointestinal bleeding \nPatients who'd had previous gastric surgery \nPatients with chronic liver disease \nPatients with abnormal coagulation or any other contra-indication to use of standard biopsy in routine diagnostic endoscopic procedures \nPatients who are unable or unwilling to give informed consent \nPatients under the age of 18 years \n \n"
],
"offsets": [
[
0,
704
]
]
}
] | [
{
"id": "NCT02385045_exc_T1",
"type": "Procedure",
"text": [
"therapeutic endoscopic procedure"
],
"offsets": [
[
25,
57
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T2",
"type": "Procedure",
"text": [
"variceal banding"
],
"offsets": [
[
63,
79
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T3",
"type": "Procedure",
"text": [
"stent insertion"
],
"offsets": [
[
81,
96
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T4",
"type": "Procedure",
"text": [
"balloon dilatation"
],
"offsets": [
[
98,
116
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T5",
"type": "Scope",
"text": [
"variceal banding, stent insertion, balloon dilatation"
],
"offsets": [
[
63,
116
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T6",
"type": "Condition",
"text": [
"upper gastrointestinal cancer"
],
"offsets": [
[
156,
185
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T7",
"type": "Condition",
"text": [
"known diagnosis"
],
"offsets": [
[
135,
150
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T8",
"type": "Procedure",
"text": [
"HP eradication therapy"
],
"offsets": [
[
220,
242
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T9",
"type": "Drug",
"text": [
"PPI"
],
"offsets": [
[
267,
270
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T10",
"type": "Drug",
"text": [
"H2 receptor antagonists"
],
"offsets": [
[
272,
295
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T11",
"type": "Drug",
"text": [
"antibiotics"
],
"offsets": [
[
300,
311
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T12",
"type": "Temporal",
"text": [
"within 4 weeks"
],
"offsets": [
[
312,
326
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T14",
"type": "Scope",
"text": [
"PPI, H2 receptor antagonists and antibiotics"
],
"offsets": [
[
267,
311
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T15",
"type": "Condition",
"text": [
"gastrointestinal bleeding"
],
"offsets": [
[
348,
373
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T16",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
342,
347
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T17",
"type": "Procedure",
"text": [
"gastric surgery"
],
"offsets": [
[
403,
418
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T18",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
394,
402
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T19",
"type": "Procedure",
"text": [
"liver disease"
],
"offsets": [
[
442,
455
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T20",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
434,
441
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T21",
"type": "Condition",
"text": [
"abnormal coagulation"
],
"offsets": [
[
471,
491
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T22",
"type": "Condition",
"text": [
"contra-indication"
],
"offsets": [
[
505,
522
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T23",
"type": "Procedure",
"text": [
"standard biopsy"
],
"offsets": [
[
533,
548
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T24",
"type": "Procedure",
"text": [
"diagnostic endoscopic procedures"
],
"offsets": [
[
560,
592
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T26",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
676,
679
]
],
"normalized": []
},
{
"id": "NCT02385045_exc_T27",
"type": "Value",
"text": [
"under",
"18 years"
],
"offsets": [
[
666,
671
],
[
683,
691
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02385045_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02385045_exc_T1",
"arg2_id": "NCT02385045_exc_T5",
"normalized": []
},
{
"id": "NCT02385045_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02385045_exc_T7",
"arg2_id": "NCT02385045_exc_T6",
"normalized": []
},
{
"id": "NCT02385045_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT02385045_exc_T14",
"arg2_id": "NCT02385045_exc_T12",
"normalized": []
},
{
"id": "NCT02385045_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02385045_exc_T15",
"arg2_id": "NCT02385045_exc_T16",
"normalized": []
},
{
"id": "NCT02385045_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02385045_exc_T17",
"arg2_id": "NCT02385045_exc_T18",
"normalized": []
},
{
"id": "NCT02385045_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02385045_exc_T19",
"arg2_id": "NCT02385045_exc_T20",
"normalized": []
},
{
"id": "NCT02385045_exc_R7",
"type": "AND",
"arg1_id": "NCT02385045_exc_T22",
"arg2_id": "NCT02385045_exc_T23",
"normalized": []
},
{
"id": "NCT02385045_exc_R8",
"type": "Has_value",
"arg1_id": "NCT02385045_exc_T26",
"arg2_id": "NCT02385045_exc_T27",
"normalized": []
}
] |
NCT02385045_inc | NCT02385045 | [
{
"id": "NCT02385045_inc_text",
"type": "inclusion",
"text": [
"• All patients attending for a routine diagnostic endoscopic procedure at St Mary's Hospital NHS Trust for dyspepsia and abdominal pain \n"
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "NCT02385045_inc_T1",
"type": "Condition",
"text": [
"dyspepsia"
],
"offsets": [
[
107,
116
]
],
"normalized": []
},
{
"id": "NCT02385045_inc_T2",
"type": "Condition",
"text": [
"abdominal pain"
],
"offsets": [
[
121,
135
]
],
"normalized": []
},
{
"id": "NCT02385045_inc_T3",
"type": "Procedure",
"text": [
"diagnostic endoscopic procedure"
],
"offsets": [
[
39,
70
]
],
"normalized": []
},
{
"id": "NCT02385045_inc_T4",
"type": "Visit",
"text": [
"St Mary's Hospital NHS Trust"
],
"offsets": [
[
74,
102
]
],
"normalized": []
},
{
"id": "NCT02385045_inc_T5",
"type": "Scope",
"text": [
"dyspepsia and abdominal pain"
],
"offsets": [
[
107,
135
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02385045_inc_R1",
"type": "AND",
"arg1_id": "NCT02385045_inc_T3",
"arg2_id": "NCT02385045_inc_T4",
"normalized": []
},
{
"id": "NCT02385045_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02385045_inc_T3",
"arg2_id": "NCT02385045_inc_T5",
"normalized": []
}
] |
NCT02385448_exc | NCT02385448 | [
{
"id": "NCT02385448_exc_text",
"type": "exclusion",
"text": [
"Operative findings not suggestive of endometriotic cyst\nContraindications to progestogens or oral contraceptive pills\nUnwillingness to tolerate menstrual irregularity\nPlanning pregnancy within 2 years of study\nCannot understand English, Cantonese or Putonghua\n"
],
"offsets": [
[
0,
260
]
]
}
] | [
{
"id": "NCT02385448_exc_T1",
"type": "Condition",
"text": [
"Operative findings"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T2",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T3",
"type": "Mood",
"text": [
"suggestive"
],
"offsets": [
[
23,
33
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T4",
"type": "Condition",
"text": [
"endometriotic cyst"
],
"offsets": [
[
37,
55
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T5",
"type": "Condition",
"text": [
"Contraindications"
],
"offsets": [
[
56,
73
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T6",
"type": "Drug",
"text": [
"progestogens"
],
"offsets": [
[
77,
89
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T7",
"type": "Drug",
"text": [
"oral contraceptive pills"
],
"offsets": [
[
93,
117
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T8",
"type": "Scope",
"text": [
"progestogens or oral contraceptive pills"
],
"offsets": [
[
77,
117
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T9",
"type": "Condition",
"text": [
"menstrual irregularity"
],
"offsets": [
[
144,
166
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T10",
"type": "Mood",
"text": [
"Unwillingness to tolerate"
],
"offsets": [
[
118,
143
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T11",
"type": "Mood",
"text": [
"Planning"
],
"offsets": [
[
167,
175
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T12",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
176,
185
]
],
"normalized": []
},
{
"id": "NCT02385448_exc_T13",
"type": "Temporal",
"text": [
"within 2 years of study"
],
"offsets": [
[
186,
209
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02385448_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT02385448_exc_T3",
"arg2_id": "NCT02385448_exc_T2",
"normalized": []
},
{
"id": "NCT02385448_exc_R2",
"type": "AND",
"arg1_id": "NCT02385448_exc_T1",
"arg2_id": "NCT02385448_exc_T4",
"normalized": []
},
{
"id": "NCT02385448_exc_R3",
"type": "Has_mood",
"arg1_id": "NCT02385448_exc_T4",
"arg2_id": "NCT02385448_exc_T3",
"normalized": []
},
{
"id": "NCT02385448_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT02385448_exc_T5",
"arg2_id": "NCT02385448_exc_T8",
"normalized": []
},
{
"id": "NCT02385448_exc_R5",
"type": "Has_mood",
"arg1_id": "NCT02385448_exc_T9",
"arg2_id": "NCT02385448_exc_T10",
"normalized": []
},
{
"id": "NCT02385448_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02385448_exc_T12",
"arg2_id": "NCT02385448_exc_T13",
"normalized": []
},
{
"id": "NCT02385448_exc_R7",
"type": "Has_mood",
"arg1_id": "NCT02385448_exc_T12",
"arg2_id": "NCT02385448_exc_T11",
"normalized": []
}
] |
NCT02385448_inc | NCT02385448 | [
{
"id": "NCT02385448_inc_text",
"type": "inclusion",
"text": [
"Good general health\nOlder than the age of legal consent (i.e. 18 years old)\nSonographic diagnosis of ovarian endometrioma with diameter at least 4cm on 2 separate scans at least 6 weeks apart\nNo contraindication to use of progesterone or combined oral contraceptive pills\nNot attempting to conceive either at the time of study entry or for at least 2 years after surgery\nWilling and able to participate after the study has been explained\n"
],
"offsets": [
[
0,
438
]
]
}
] | [
{
"id": "NCT02385448_inc_T1",
"type": "Condition",
"text": [
"Good general health"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T2",
"type": "Value",
"text": [
"Older than the age of legal consent"
],
"offsets": [
[
20,
55
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T4",
"type": "Value",
"text": [
"18 years old"
],
"offsets": [
[
62,
74
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T5",
"type": "Procedure",
"text": [
"Sonographic"
],
"offsets": [
[
76,
87
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T6",
"type": "Condition",
"text": [
"ovarian endometrioma"
],
"offsets": [
[
101,
121
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T7",
"type": "Qualifier",
"text": [
"diameter at least 4cm"
],
"offsets": [
[
127,
148
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T8",
"type": "Multiplier",
"text": [
"2 separate scans"
],
"offsets": [
[
152,
168
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T9",
"type": "Temporal",
"text": [
"at least 6 weeks apart"
],
"offsets": [
[
169,
191
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T10",
"type": "Scope",
"text": [
"Sonographic diagnosis of ovarian endometrioma with diameter at least 4cm"
],
"offsets": [
[
76,
148
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T11",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
192,
194
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T12",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
195,
211
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T13",
"type": "Drug",
"text": [
"progesterone"
],
"offsets": [
[
222,
234
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T14",
"type": "Drug",
"text": [
"combined oral contraceptive pills"
],
"offsets": [
[
238,
271
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T15",
"type": "Scope",
"text": [
"progesterone or combined oral contraceptive pills"
],
"offsets": [
[
222,
271
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T16",
"type": "Mood",
"text": [
"attempting"
],
"offsets": [
[
276,
286
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T17",
"type": "Procedure",
"text": [
"conceive"
],
"offsets": [
[
290,
298
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T18",
"type": "Temporal",
"text": [
"at the time of study entry"
],
"offsets": [
[
306,
332
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T19",
"type": "Temporal",
"text": [
"for at least 2 years after surgery"
],
"offsets": [
[
336,
370
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T20",
"type": "Scope",
"text": [
"at the time of study entry or for at least 2 years after surgery"
],
"offsets": [
[
306,
370
]
],
"normalized": []
},
{
"id": "NCT02385448_inc_T21",
"type": "Negation",
"text": [
"Not"
],
"offsets": [
[
272,
275
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02385448_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02385448_inc_T3",
"arg2_id": "NCT02385448_inc_T2",
"normalized": []
},
{
"id": "NCT02385448_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT02385448_inc_T2",
"arg2_id": "NCT02385448_inc_T4",
"normalized": []
},
{
"id": "NCT02385448_inc_R3",
"type": "AND",
"arg1_id": "NCT02385448_inc_T5",
"arg2_id": "NCT02385448_inc_T6",
"normalized": []
},
{
"id": "NCT02385448_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02385448_inc_T6",
"arg2_id": "NCT02385448_inc_T7",
"normalized": []
},
{
"id": "NCT02385448_inc_R4",
"type": "Has_multiplier",
"arg1_id": "NCT02385448_inc_T5",
"arg2_id": "NCT02385448_inc_T8",
"normalized": []
},
{
"id": "NCT02385448_inc_R5",
"type": "Has_temporal",
"arg1_id": "NCT02385448_inc_T8",
"arg2_id": "NCT02385448_inc_T9",
"normalized": []
},
{
"id": "NCT02385448_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT02385448_inc_T12",
"arg2_id": "NCT02385448_inc_T11",
"normalized": []
},
{
"id": "NCT02385448_inc_R8",
"type": "Has_scope",
"arg1_id": "NCT02385448_inc_T12",
"arg2_id": "NCT02385448_inc_T15",
"normalized": []
},
{
"id": "NCT02385448_inc_R9",
"type": "Has_mood",
"arg1_id": "NCT02385448_inc_T17",
"arg2_id": "NCT02385448_inc_T16",
"normalized": []
},
{
"id": "NCT02385448_inc_R10",
"type": "Has_negation",
"arg1_id": "NCT02385448_inc_T16",
"arg2_id": "NCT02385448_inc_T21",
"normalized": []
},
{
"id": "NCT02385448_inc_R11",
"type": "Has_scope",
"arg1_id": "NCT02385448_inc_T17",
"arg2_id": "NCT02385448_inc_T20",
"normalized": []
}
] |
NCT02386800_exc | NCT02386800 | [
{
"id": "NCT02386800_exc_text",
"type": "exclusion",
"text": [
"Patient has participated in a combination trial where ruxolitinib was dispensed in combination with another study medication and the patient is still receiving combination therapy.\nPregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.\nWomen of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception throughout the study duration inclusive of the 30-day safety follow up.\n"
],
"offsets": [
[
0,
611
]
]
}
] | [] | [] | [] | [] |
NCT02386800_inc | NCT02386800 | [
{
"id": "NCT02386800_inc_text",
"type": "inclusion",
"text": [
"Patient is currently enrolled in a Novartis OGD or GMA-sponsored or Incyte-sponsored clinical study (where Incyte can delegate the sponsorship to a preferred CRO, if applicable) that is approved to enroll into this rollover study, is receiving ruxolitinib and has fulfilled all of the requirements of the parent protocol.\nPatient is currently benefiting from the treatment with ruxolitinib, as determined by the investigator\nPatient has demonstrated compliance, as assessed by the investigator, with the parent study protocol requirements Willingness and ability to comply with scheduled visits, treatment plans and any other study procedures\nPatient currently has no evidence of progressive disease, as determined by the investigator, following previous treatment with ruxolitinib\nWritten informed consent obtained prior to enrolling in roll-over study and receiving study medication. If consent cannot be expressed in writing, it must be formally documented and witnessed, ideally via an independent trusted witness.\n"
],
"offsets": [
[
0,
1019
]
]
}
] | [
{
"id": "NCT02386800_inc_T2",
"type": "Drug",
"text": [
"ruxolitinib"
],
"offsets": [
[
378,
389
]
],
"normalized": []
},
{
"id": "NCT02386800_inc_T5",
"type": "Condition",
"text": [
"progressive disease"
],
"offsets": [
[
680,
699
]
],
"normalized": []
},
{
"id": "NCT02386800_inc_T6",
"type": "Drug",
"text": [
"ruxolitinib"
],
"offsets": [
[
770,
781
]
],
"normalized": []
}
] | [] | [] | [] |
NCT02390973_exc | NCT02390973 | [
{
"id": "NCT02390973_exc_text",
"type": "exclusion",
"text": [
"pregnancy\npast esophageal, gastric or bariatric surgery\nirritable bowel, unexplained intermittent vomiting, severe abdominal pain, chronic diarrhea or constipation\nhistory of gastric or duodenal ulcers\npre-operatory hypoalbuminemy\nhistory of renal, hepatic, cardiac or pulmonary severe disease\ntaken of corticosteroid in the last month\nevidence of psycological problem that may affect the capacity to understand the project and to comply with the medical recommandations\nhistory of drug use or alcool abuse in the last 12 months\nhistory of gastro-intestinal inflammatory diseases\n"
],
"offsets": [
[
0,
580
]
]
}
] | [
{
"id": "NCT02390973_exc_T1",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T2",
"type": "Procedure",
"text": [
"bariatric surgery"
],
"offsets": [
[
38,
55
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T3",
"type": "Procedure",
"text": [
"astric",
"urgery"
],
"offsets": [
[
28,
34
],
[
49,
55
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T4",
"type": "Procedure",
"text": [
"sophageal,",
"urgery"
],
"offsets": [
[
16,
26
],
[
49,
55
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T5",
"type": "Condition",
"text": [
"irritable bowel"
],
"offsets": [
[
56,
71
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T6",
"type": "Condition",
"text": [
"vomiting"
],
"offsets": [
[
98,
106
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T7",
"type": "Condition",
"text": [
"abdominal pain"
],
"offsets": [
[
115,
129
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T8",
"type": "Qualifier",
"text": [
"intermittent"
],
"offsets": [
[
85,
97
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T9",
"type": "Condition",
"text": [
"diarrhea"
],
"offsets": [
[
139,
147
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T10",
"type": "Condition",
"text": [
"constipation"
],
"offsets": [
[
151,
163
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T11",
"type": "Scope",
"text": [
"diarrhea or constipation"
],
"offsets": [
[
139,
163
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T12",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
131,
138
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T13",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
108,
114
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T14",
"type": "Condition",
"text": [
"duodenal ulcers"
],
"offsets": [
[
186,
201
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T15",
"type": "Condition",
"text": [
"tric or",
"ers\npr"
],
"offsets": [
[
178,
185
],
[
198,
204
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T16",
"type": "Condition",
"text": [
"hypoalbuminemy"
],
"offsets": [
[
216,
230
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T17",
"type": "Qualifier",
"text": [
"pre-operatory"
],
"offsets": [
[
202,
215
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T18",
"type": "Condition",
"text": [
"nary seve",
"se\ntake"
],
"offsets": [
[
274,
283
],
[
291,
298
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T19",
"type": "Condition",
"text": [
"ac or p",
"se\ntake"
],
"offsets": [
[
263,
270
],
[
291,
298
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T20",
"type": "Condition",
"text": [
"ic, car",
"se\ntake"
],
"offsets": [
[
254,
261
],
[
291,
298
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T21",
"type": "Condition",
"text": [
", hep",
"se\ntake"
],
"offsets": [
[
247,
252
],
[
291,
298
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T22",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
279,
285
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T23",
"type": "Drug",
"text": [
"corticosteroid"
],
"offsets": [
[
303,
317
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T24",
"type": "Temporal",
"text": [
"last month"
],
"offsets": [
[
325,
335
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T26",
"type": "Condition",
"text": [
"alcool abuse"
],
"offsets": [
[
494,
506
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T27",
"type": "Condition",
"text": [
"drug use"
],
"offsets": [
[
482,
490
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T28",
"type": "Temporal",
"text": [
"last 12 months"
],
"offsets": [
[
514,
528
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T29",
"type": "Scope",
"text": [
"drug use or alcool abuse"
],
"offsets": [
[
482,
506
]
],
"normalized": []
},
{
"id": "NCT02390973_exc_T30",
"type": "Condition",
"text": [
"gastro-intestinal inflammatory diseases"
],
"offsets": [
[
540,
579
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02390973_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T11",
"arg2_id": "NCT02390973_exc_T12",
"normalized": []
},
{
"id": "NCT02390973_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T7",
"arg2_id": "NCT02390973_exc_T13",
"normalized": []
},
{
"id": "NCT02390973_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T6",
"arg2_id": "NCT02390973_exc_T8",
"normalized": []
},
{
"id": "NCT02390973_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T16",
"arg2_id": "NCT02390973_exc_T17",
"normalized": []
},
{
"id": "NCT02390973_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T18",
"arg2_id": "NCT02390973_exc_T22",
"normalized": []
},
{
"id": "NCT02390973_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T20",
"arg2_id": "NCT02390973_exc_T22",
"normalized": []
},
{
"id": "NCT02390973_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T20",
"arg2_id": "NCT02390973_exc_T22",
"normalized": []
},
{
"id": "NCT02390973_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02390973_exc_T20",
"arg2_id": "NCT02390973_exc_T22",
"normalized": []
},
{
"id": "NCT02390973_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02390973_exc_T23",
"arg2_id": "NCT02390973_exc_T24",
"normalized": []
},
{
"id": "NCT02390973_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02390973_exc_T29",
"arg2_id": "NCT02390973_exc_T28",
"normalized": []
}
] |
NCT02390973_inc | NCT02390973 | [
{
"id": "NCT02390973_inc_text",
"type": "inclusion",
"text": [
"BMI = 35\ntype 2 diabetes\nHbA1c = 6,5 % or fasting glycemia =7mmol/l or non-fasting glycemia =11mmol/l\nable to consent\n"
],
"offsets": [
[
0,
118
]
]
}
] | [
{
"id": "NCT02390973_inc_T1",
"type": "Measurement",
"text": [
"BMI"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T2",
"type": "Value",
"text": [
"= 35"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T3",
"type": "Condition",
"text": [
"type 2 diabetes"
],
"offsets": [
[
9,
24
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T4",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
25,
30
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T5",
"type": "Value",
"text": [
"= 6,5 %"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T6",
"type": "Measurement",
"text": [
"fasting glycemia"
],
"offsets": [
[
42,
58
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T7",
"type": "Value",
"text": [
"=7mmol/l"
],
"offsets": [
[
59,
67
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T8",
"type": "Measurement",
"text": [
"non-fasting glycemia"
],
"offsets": [
[
71,
91
]
],
"normalized": []
},
{
"id": "NCT02390973_inc_T9",
"type": "Value",
"text": [
"=11mmol/l"
],
"offsets": [
[
92,
101
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02390973_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02390973_inc_T4",
"arg2_id": "NCT02390973_inc_T5",
"normalized": []
},
{
"id": "NCT02390973_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02390973_inc_T6",
"arg2_id": "NCT02390973_inc_T7",
"normalized": []
},
{
"id": "NCT02390973_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02390973_inc_T8",
"arg2_id": "NCT02390973_inc_T9",
"normalized": []
}
] |
NCT02393287_exc | NCT02393287 | [
{
"id": "NCT02393287_exc_text",
"type": "exclusion",
"text": [
"1. Presence of other neoplasia \n2. Man \n \n"
],
"offsets": [
[
0,
51
]
]
}
] | [
{
"id": "NCT02393287_exc_T3",
"type": "Condition",
"text": [
"neoplasia"
],
"offsets": [
[
21,
30
]
],
"normalized": []
},
{
"id": "NCT02393287_exc_T4",
"type": "Person",
"text": [
"Man"
],
"offsets": [
[
35,
38
]
],
"normalized": []
},
{
"id": "NCT02393287_exc_T5",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
15,
20
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02393287_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02393287_exc_T3",
"arg2_id": "NCT02393287_exc_T5",
"normalized": []
}
] |
NCT02393287_inc | NCT02393287 | [
{
"id": "NCT02393287_inc_text",
"type": "inclusion",
"text": [
"1. Age ≥ 18 years \n2. Patient with breast cancer, histologically proven, metastatic or locally advanced \n3. Patient treated by Eribulin between January and October 2014 (for the retrospective part) or between November 2014 and September 2015 (for the prospective part). \n4. Patient with at least an assessment of the response to Eribulin \n"
],
"offsets": [
[
0,
339
]
]
}
] | [
{
"id": "NCT02393287_inc_T5",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
3,
6
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T6",
"type": "Value",
"text": [
"≥ 18 years"
],
"offsets": [
[
7,
17
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T7",
"type": "Condition",
"text": [
"breast cancer"
],
"offsets": [
[
35,
48
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T8",
"type": "Procedure",
"text": [
"histologically"
],
"offsets": [
[
50,
64
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T9",
"type": "Value",
"text": [
"proven"
],
"offsets": [
[
65,
71
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T10",
"type": "Qualifier",
"text": [
"metastatic"
],
"offsets": [
[
73,
83
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T11",
"type": "Qualifier",
"text": [
"locally advanced"
],
"offsets": [
[
87,
103
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T12",
"type": "Scope",
"text": [
"histologically proven, metastatic or locally advanced"
],
"offsets": [
[
50,
103
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T13",
"type": "Drug",
"text": [
"Eribulin"
],
"offsets": [
[
127,
135
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T14",
"type": "Temporal",
"text": [
"between January and October 2014"
],
"offsets": [
[
136,
168
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T15",
"type": "Temporal",
"text": [
"between November 2014 and September 2015"
],
"offsets": [
[
201,
241
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T16",
"type": "Scope",
"text": [
"between January and October 2014 (for the retrospective part) or between November 2014 and September 2015 (for the prospective part)"
],
"offsets": [
[
136,
268
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T17",
"type": "Drug",
"text": [
"Eribulin"
],
"offsets": [
[
329,
337
]
],
"normalized": []
},
{
"id": "NCT02393287_inc_T18",
"type": "Procedure",
"text": [
"assessment of the response"
],
"offsets": [
[
299,
325
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02393287_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02393287_inc_T5",
"arg2_id": "NCT02393287_inc_T6",
"normalized": []
},
{
"id": "NCT02393287_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02393287_inc_T8",
"arg2_id": "NCT02393287_inc_T9",
"normalized": []
},
{
"id": "NCT02393287_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02393287_inc_T7",
"arg2_id": "NCT02393287_inc_T12",
"normalized": []
},
{
"id": "NCT02393287_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02393287_inc_T13",
"arg2_id": "NCT02393287_inc_T16",
"normalized": []
}
] |
NCT02394158_exc | NCT02394158 | [
{
"id": "NCT02394158_exc_text",
"type": "exclusion",
"text": [
"Established pre-existing diabetes (including unrecognised diabetes defined as a fasting plasma glucose = 7.0mmol/L and/ or HbA1c = 48mmol/mol); Contraindications to metformin therapy (creatinine = 130µmol/L/ alanine transaminase = 2.0 x upper limit normal/ previous intolerance to metformin)\nPlanned continued antenatal care/ delivery at centre not included in trial\nPlanned fast for cultural/ religious reasons e.g. Ramadan\n"
],
"offsets": [
[
0,
425
]
]
}
] | [
{
"id": "NCT02394158_exc_T1",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
25,
33
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T2",
"type": "Measurement",
"text": [
"fasting plasma glucose"
],
"offsets": [
[
80,
102
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T3",
"type": "Value",
"text": [
"= 7.0mmol/L"
],
"offsets": [
[
103,
114
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T4",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T5",
"type": "Value",
"text": [
"= 48mmol/mol)"
],
"offsets": [
[
129,
142
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T6",
"type": "Condition",
"text": [
"Contraindications"
],
"offsets": [
[
144,
161
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T7",
"type": "Drug",
"text": [
"metformin"
],
"offsets": [
[
165,
174
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T8",
"type": "Measurement",
"text": [
"creatinine"
],
"offsets": [
[
184,
194
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T9",
"type": "Value",
"text": [
"= 130µmol/L/"
],
"offsets": [
[
195,
207
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T10",
"type": "Measurement",
"text": [
"alanine transaminase"
],
"offsets": [
[
208,
228
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T11",
"type": "Value",
"text": [
"= 2.0 x upper limit normal"
],
"offsets": [
[
229,
255
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T12",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
266,
277
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T13",
"type": "Drug",
"text": [
"metformin"
],
"offsets": [
[
281,
290
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T14",
"type": "Scope",
"text": [
"fasting plasma glucose = 7.0mmol/L and/ or HbA1c = 48mmol/mol"
],
"offsets": [
[
80,
141
]
],
"normalized": []
},
{
"id": "NCT02394158_exc_T15",
"type": "Scope",
"text": [
"creatinine = 130µmol/L/ alanine transaminase = 2.0 x upper limit normal/ previous intolerance to metformin"
],
"offsets": [
[
184,
290
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02394158_exc_R1",
"type": "Has_value",
"arg1_id": "NCT02394158_exc_T2",
"arg2_id": "NCT02394158_exc_T3",
"normalized": []
},
{
"id": "NCT02394158_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02394158_exc_T4",
"arg2_id": "NCT02394158_exc_T5",
"normalized": []
},
{
"id": "NCT02394158_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT02394158_exc_T1",
"arg2_id": "NCT02394158_exc_T14",
"normalized": []
},
{
"id": "NCT02394158_exc_R4",
"type": "AND",
"arg1_id": "NCT02394158_exc_T6",
"arg2_id": "NCT02394158_exc_T7",
"normalized": []
},
{
"id": "NCT02394158_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02394158_exc_T8",
"arg2_id": "NCT02394158_exc_T9",
"normalized": []
},
{
"id": "NCT02394158_exc_R6",
"type": "Has_value",
"arg1_id": "NCT02394158_exc_T10",
"arg2_id": "NCT02394158_exc_T11",
"normalized": []
},
{
"id": "NCT02394158_exc_R7",
"type": "AND",
"arg1_id": "NCT02394158_exc_T12",
"arg2_id": "NCT02394158_exc_T13",
"normalized": []
},
{
"id": "NCT02394158_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT02394158_exc_T6",
"arg2_id": "NCT02394158_exc_T15",
"normalized": []
}
] |
NCT02394158_inc | NCT02394158 | [
{
"id": "NCT02394158_inc_text",
"type": "inclusion",
"text": [
"Singleton pregnancy;\n8-22 weeks gestation\nPrevious pregnancy complicated by gestational diabetes\n"
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "NCT02394158_inc_T1",
"type": "Condition",
"text": [
"Singleton pregnancy"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT02394158_inc_T2",
"type": "Condition",
"text": [
"gestation"
],
"offsets": [
[
32,
41
]
],
"normalized": []
},
{
"id": "NCT02394158_inc_T3",
"type": "Multiplier",
"text": [
"8-22 weeks"
],
"offsets": [
[
21,
31
]
],
"normalized": []
},
{
"id": "NCT02394158_inc_T4",
"type": "Condition",
"text": [
"gestational diabetes"
],
"offsets": [
[
76,
96
]
],
"normalized": []
},
{
"id": "NCT02394158_inc_T5",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
51,
60
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02394158_inc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT02394158_inc_T2",
"arg2_id": "NCT02394158_inc_T3",
"normalized": []
},
{
"id": "NCT02394158_inc_R2",
"type": "AND",
"arg1_id": "NCT02394158_inc_T5",
"arg2_id": "NCT02394158_inc_T4",
"normalized": []
}
] |
NCT02396420_exc | NCT02396420 | [
{
"id": "NCT02396420_exc_text",
"type": "exclusion",
"text": [
"History of prostate, bladder, or rectal cancer \nHistory of transurethral resection of the prostate (TURP), open prostate surgery, or radiofrequency or microwave therapies \nHistory of open bladder, rectosigmoid colon, or other pelvic surgery \nPatient is unwilling to discontinue alpha blockers 1 month after study treatment \nPatient is unwilling to discontinue 5-alph reductase inhibitors 1 month after study treatment \nNeurogenic bladder or other neurologic disorder impacting bladder function such as Parkinson's disease, multiple sclerosis, cerebral vascular accident or diabetes \nAny other confounding bladder or urethral pathology, including urethral stricture, bladder neck contracture, or bladder atonia \nActive prostatitis or urinary tract infection \nCystolithiasis within the past 3 months \nSerum creatinine > 1.7mg/dL \nInability to discontinue oral anticoagulant 2-5 days prior to study treatment \nCoagulation disturbances not normalized by medical treatment \nIodinated contrast allergy that, in the opinion of the Investigator, cannot be adequately premedicated \nGelatin allergy \nKnown severe peripheral vascular disease or major iliac arterial occlusive disease \nInterest in future fertility \nClinically significant cardiac arrhythmia or other cardiac disease (including congestive heart failure), uncontrolled diabetes mellitus, clinically significant respiratory disease, or known immunosuppression \nOther condition that the Investigator believes puts the patient at risk for a complication during the procedure \n \n"
],
"offsets": [
[
0,
1537
]
]
}
] | [
{
"id": "NCT02396420_exc_T1",
"type": "Condition",
"text": [
"rectal cancer"
],
"offsets": [
[
33,
46
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T2",
"type": "Condition",
"text": [
"bladder",
"cancer"
],
"offsets": [
[
21,
28
],
[
40,
46
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T3",
"type": "Condition",
"text": [
"prostate",
"cancer"
],
"offsets": [
[
11,
19
],
[
40,
46
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T4",
"type": "Procedure",
"text": [
"transurethral resection of the prostate (TURP)"
],
"offsets": [
[
59,
105
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T5",
"type": "Procedure",
"text": [
"open prostate surgery"
],
"offsets": [
[
107,
128
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T6",
"type": "Procedure",
"text": [
"radiofrequency"
],
"offsets": [
[
133,
147
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T7",
"type": "Procedure",
"text": [
"microwave therapies"
],
"offsets": [
[
151,
170
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T8",
"type": "Procedure",
"text": [
"open bladder",
"surgery"
],
"offsets": [
[
183,
195
],
[
233,
240
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T9",
"type": "Procedure",
"text": [
"pelvic surgery"
],
"offsets": [
[
226,
240
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T10",
"type": "Procedure",
"text": [
"rectosigmoid colon",
"surgery"
],
"offsets": [
[
197,
215
],
[
233,
240
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T12",
"type": "Drug",
"text": [
"alpha blockers"
],
"offsets": [
[
278,
292
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T13",
"type": "Drug",
"text": [
"5-alph reductase inhibitors"
],
"offsets": [
[
360,
387
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T14",
"type": "Temporal",
"text": [
"1 month after study treatment"
],
"offsets": [
[
293,
322
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T15",
"type": "Reference_point",
"text": [
"study treatment"
],
"offsets": [
[
307,
322
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T16",
"type": "Temporal",
"text": [
"1 month after study treatment"
],
"offsets": [
[
388,
417
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T18",
"type": "Condition",
"text": [
"Neurogenic bladder"
],
"offsets": [
[
419,
437
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T19",
"type": "Condition",
"text": [
"neurologic disorder impacting bladder function"
],
"offsets": [
[
447,
493
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T20",
"type": "Condition",
"text": [
"Parkinson's disease"
],
"offsets": [
[
502,
521
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T21",
"type": "Condition",
"text": [
"multiple sclerosis"
],
"offsets": [
[
523,
541
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T22",
"type": "Condition",
"text": [
"cerebral vascular accident"
],
"offsets": [
[
543,
569
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T23",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
573,
581
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T24",
"type": "Scope",
"text": [
"Neurogenic bladder",
"Parkinson's disease, multiple sclerosis, cerebral vascular accident or diabetes"
],
"offsets": [
[
419,
437
],
[
502,
581
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T25",
"type": "Condition",
"text": [
"urethral pathology"
],
"offsets": [
[
616,
634
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T27",
"type": "Condition",
"text": [
"urethral stricture"
],
"offsets": [
[
646,
664
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T28",
"type": "Condition",
"text": [
"bladder neck contracture"
],
"offsets": [
[
666,
690
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T29",
"type": "Condition",
"text": [
"bladder atonia"
],
"offsets": [
[
695,
709
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T30",
"type": "Condition",
"text": [
"bladder",
"pathology"
],
"offsets": [
[
605,
612
],
[
625,
634
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T32",
"type": "Scope",
"text": [
"bladder or urethral pathology"
],
"offsets": [
[
605,
634
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T33",
"type": "Scope",
"text": [
"urethral stricture, bladder neck contracture, or bladder atonia"
],
"offsets": [
[
646,
709
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T34",
"type": "Condition",
"text": [
"prostatitis"
],
"offsets": [
[
718,
729
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T35",
"type": "Condition",
"text": [
"urinary tract infection"
],
"offsets": [
[
733,
756
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T36",
"type": "Temporal",
"text": [
"Active"
],
"offsets": [
[
711,
717
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T37",
"type": "Condition",
"text": [
"Cystolithiasis"
],
"offsets": [
[
758,
772
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T38",
"type": "Temporal",
"text": [
"within the past 3 months"
],
"offsets": [
[
773,
797
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T39",
"type": "Measurement",
"text": [
"Serum creatinine"
],
"offsets": [
[
799,
815
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T40",
"type": "Value",
"text": [
"> 1.7mg/dL"
],
"offsets": [
[
816,
826
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T41",
"type": "Drug",
"text": [
"oral anticoagulant"
],
"offsets": [
[
853,
871
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T42",
"type": "Temporal",
"text": [
"2-5 days prior to study treatment"
],
"offsets": [
[
872,
905
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T43",
"type": "Reference_point",
"text": [
"study treatment"
],
"offsets": [
[
890,
905
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T45",
"type": "Condition",
"text": [
"Coagulation disturbances"
],
"offsets": [
[
907,
931
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T47",
"type": "Procedure",
"text": [
"medical treatment"
],
"offsets": [
[
950,
967
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T48",
"type": "Qualifier",
"text": [
"normalized"
],
"offsets": [
[
936,
946
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T49",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
932,
935
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T50",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
988,
995
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T51",
"type": "Drug",
"text": [
"Iodinated contrast"
],
"offsets": [
[
969,
987
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T53",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
1081,
1088
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T54",
"type": "Drug",
"text": [
"Gelatin"
],
"offsets": [
[
1073,
1080
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T55",
"type": "Condition",
"text": [
"peripheral vascular disease"
],
"offsets": [
[
1103,
1130
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T56",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
1096,
1102
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T57",
"type": "Condition",
"text": [
"iliac arterial occlusive disease"
],
"offsets": [
[
1140,
1172
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T58",
"type": "Qualifier",
"text": [
"major"
],
"offsets": [
[
1134,
1139
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T63",
"type": "Condition",
"text": [
"cardiac arrhythmia"
],
"offsets": [
[
1227,
1245
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T64",
"type": "Condition",
"text": [
"cardiac disease"
],
"offsets": [
[
1255,
1270
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T65",
"type": "Condition",
"text": [
"congestive heart failure"
],
"offsets": [
[
1282,
1306
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T66",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
1322,
1339
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T67",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
1309,
1321
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T68",
"type": "Condition",
"text": [
"respiratory disease"
],
"offsets": [
[
1364,
1383
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T69",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
1341,
1363
]
],
"normalized": []
},
{
"id": "NCT02396420_exc_T72",
"type": "Condition",
"text": [
"immunosuppression"
],
"offsets": [
[
1394,
1411
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02396420_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02396420_exc_T9",
"arg2_id": "NCT02396420_exc_T10",
"normalized": []
},
{
"id": "NCT02396420_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT02396420_exc_T9",
"arg2_id": "NCT02396420_exc_T8",
"normalized": []
},
{
"id": "NCT02396420_exc_R3",
"type": "Has_index",
"arg1_id": "NCT02396420_exc_T14",
"arg2_id": "NCT02396420_exc_T15",
"normalized": []
},
{
"id": "NCT02396420_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02396420_exc_T13",
"arg2_id": "NCT02396420_exc_T16",
"normalized": []
},
{
"id": "NCT02396420_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02396420_exc_T19",
"arg2_id": "NCT02396420_exc_T24",
"normalized": []
},
{
"id": "NCT02396420_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02396420_exc_T32",
"arg2_id": "NCT02396420_exc_T33",
"normalized": []
},
{
"id": "NCT02396420_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT02396420_exc_T34",
"arg2_id": "NCT02396420_exc_T36",
"normalized": []
},
{
"id": "NCT02396420_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT02396420_exc_T35",
"arg2_id": "NCT02396420_exc_T36",
"normalized": []
},
{
"id": "NCT02396420_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02396420_exc_T39",
"arg2_id": "NCT02396420_exc_T40",
"normalized": []
},
{
"id": "NCT02396420_exc_R10",
"type": "Has_index",
"arg1_id": "NCT02396420_exc_T42",
"arg2_id": "NCT02396420_exc_T43",
"normalized": []
},
{
"id": "NCT02396420_exc_R11",
"type": "Has_negation",
"arg1_id": "NCT02396420_exc_T48",
"arg2_id": "NCT02396420_exc_T49",
"normalized": []
},
{
"id": "NCT02396420_exc_R12",
"type": "AND",
"arg1_id": "NCT02396420_exc_T48",
"arg2_id": "NCT02396420_exc_T47",
"normalized": []
},
{
"id": "NCT02396420_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT02396420_exc_T45",
"arg2_id": "NCT02396420_exc_T48",
"normalized": []
},
{
"id": "NCT02396420_exc_R14",
"type": "AND",
"arg1_id": "NCT02396420_exc_T50",
"arg2_id": "NCT02396420_exc_T51",
"normalized": []
},
{
"id": "NCT02396420_exc_R15",
"type": "AND",
"arg1_id": "NCT02396420_exc_T53",
"arg2_id": "NCT02396420_exc_T54",
"normalized": []
},
{
"id": "NCT02396420_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT02396420_exc_T55",
"arg2_id": "NCT02396420_exc_T56",
"normalized": []
},
{
"id": "NCT02396420_exc_R17",
"type": "Has_qualifier",
"arg1_id": "NCT02396420_exc_T57",
"arg2_id": "NCT02396420_exc_T58",
"normalized": []
},
{
"id": "NCT02396420_exc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT02396420_exc_T66",
"arg2_id": "NCT02396420_exc_T67",
"normalized": []
},
{
"id": "NCT02396420_exc_R19",
"type": "Has_qualifier",
"arg1_id": "NCT02396420_exc_T68",
"arg2_id": "NCT02396420_exc_T69",
"normalized": []
},
{
"id": "NCT02396420_exc_R20",
"type": "Subsumes",
"arg1_id": "NCT02396420_exc_T64",
"arg2_id": "NCT02396420_exc_T65",
"normalized": []
}
] |
NCT02396420_inc | NCT02396420 | [
{
"id": "NCT02396420_inc_text",
"type": "inclusion",
"text": [
"Patient has provided signed informed consent \nPatient is aged greater than or equal to 40 and less than or equal to 89 years of age \nPatient has a prostate size between 90g and 200g, as determined by MRI \nPatient has experienced lower urinary tract symptoms (LUTS) for at least 6 months prior to study enrollment \nPatient has an IPSS score of at least 13 at baseline \nPatient is either: refractory to medical treatment, contraindicated to medical treatment, OR refuses medical treatment \nPatient either: refuses surgical treatment OR is contraindicated for surgical treatment \nPatient meets ONE of the following criteria: baseline PSA < 4.0ng/mL (no prostate biopsy required) OR baseline PSA >/= 4 ng/mL AND a negative prostate biopsy (minimum 12 core biopsy) within the prior 12 months \n"
],
"offsets": [
[
0,
788
]
]
}
] | [
{
"id": "NCT02396420_inc_T3",
"type": "Value",
"text": [
"greater than or equal to 40"
],
"offsets": [
[
62,
89
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T4",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T5",
"type": "Value",
"text": [
"less than or equal to 89 years"
],
"offsets": [
[
94,
124
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T7",
"type": "Scope",
"text": [
"greater than or equal to 40 and less than or equal to 89 years"
],
"offsets": [
[
62,
124
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T8",
"type": "Value",
"text": [
"between 90g and 200g"
],
"offsets": [
[
161,
181
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T9",
"type": "Measurement",
"text": [
"prostate size"
],
"offsets": [
[
147,
160
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T10",
"type": "Procedure",
"text": [
"MRI"
],
"offsets": [
[
200,
203
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T11",
"type": "Condition",
"text": [
"lower urinary tract symptoms (LUTS)"
],
"offsets": [
[
229,
264
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T12",
"type": "Temporal",
"text": [
"at least 6 months prior to study enrollment"
],
"offsets": [
[
269,
312
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T13",
"type": "Reference_point",
"text": [
"study enrollment"
],
"offsets": [
[
296,
312
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T14",
"type": "Measurement",
"text": [
"IPSS score"
],
"offsets": [
[
329,
339
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T15",
"type": "Value",
"text": [
"at least 13"
],
"offsets": [
[
343,
354
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T16",
"type": "Temporal",
"text": [
"at baseline"
],
"offsets": [
[
355,
366
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T17",
"type": "Reference_point",
"text": [
"baseline"
],
"offsets": [
[
358,
366
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T18",
"type": "Condition",
"text": [
"refractory to medical treatment"
],
"offsets": [
[
387,
418
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T19",
"type": "Condition",
"text": [
"contraindicated to medical treatment"
],
"offsets": [
[
420,
456
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T20",
"type": "Condition",
"text": [
"refuses medical treatment"
],
"offsets": [
[
461,
486
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T21",
"type": "Condition",
"text": [
"refuses surgical treatment"
],
"offsets": [
[
504,
530
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T22",
"type": "Condition",
"text": [
"contraindicated for surgical treatment"
],
"offsets": [
[
537,
575
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T23",
"type": "Measurement",
"text": [
"PSA"
],
"offsets": [
[
631,
634
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T24",
"type": "Temporal",
"text": [
"baseline"
],
"offsets": [
[
622,
630
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T25",
"type": "Value",
"text": [
"< 4.0ng/mL"
],
"offsets": [
[
635,
645
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T26",
"type": "Measurement",
"text": [
"PSA"
],
"offsets": [
[
688,
691
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T27",
"type": "Temporal",
"text": [
"baseline"
],
"offsets": [
[
679,
687
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T28",
"type": "Value",
"text": [
">/= 4 ng/mL"
],
"offsets": [
[
692,
703
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T29",
"type": "Measurement",
"text": [
"prostate biopsy"
],
"offsets": [
[
719,
734
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T30",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
710,
718
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T31",
"type": "Multiplier",
"text": [
"minimum 12"
],
"offsets": [
[
736,
746
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T32",
"type": "Procedure",
"text": [
"core biopsy"
],
"offsets": [
[
747,
758
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T33",
"type": "Temporal",
"text": [
"within the prior 12 months"
],
"offsets": [
[
760,
786
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T34",
"type": "Scope",
"text": [
"baseline PSA < 4.0ng/mL (no prostate biopsy required) OR baseline PSA >/= 4 ng/mL AND a negative prostate biopsy (minimum 12 core biopsy)"
],
"offsets": [
[
622,
759
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T35",
"type": "Scope",
"text": [
"baseline PSA >/= 4 ng/mL AND a negative prostate biops"
],
"offsets": [
[
679,
733
]
],
"normalized": []
},
{
"id": "NCT02396420_inc_T1",
"type": "Observation",
"text": [
"signed informed consent"
],
"offsets": [
[
21,
44
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02396420_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT02396420_inc_T4",
"arg2_id": "NCT02396420_inc_T7",
"normalized": []
},
{
"id": "NCT02396420_inc_R3",
"type": "Has_value",
"arg1_id": "NCT02396420_inc_T9",
"arg2_id": "NCT02396420_inc_T8",
"normalized": []
},
{
"id": "NCT02396420_inc_R4",
"type": "AND",
"arg1_id": "NCT02396420_inc_T9",
"arg2_id": "NCT02396420_inc_T10",
"normalized": []
},
{
"id": "NCT02396420_inc_R5",
"type": "Has_index",
"arg1_id": "NCT02396420_inc_T12",
"arg2_id": "NCT02396420_inc_T13",
"normalized": []
},
{
"id": "NCT02396420_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02396420_inc_T11",
"arg2_id": "NCT02396420_inc_T12",
"normalized": []
},
{
"id": "NCT02396420_inc_R7",
"type": "Has_index",
"arg1_id": "NCT02396420_inc_T16",
"arg2_id": "NCT02396420_inc_T17",
"normalized": []
},
{
"id": "NCT02396420_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02396420_inc_T14",
"arg2_id": "NCT02396420_inc_T15",
"normalized": []
},
{
"id": "NCT02396420_inc_R9",
"type": "Has_temporal",
"arg1_id": "NCT02396420_inc_T14",
"arg2_id": "NCT02396420_inc_T16",
"normalized": []
},
{
"id": "NCT02396420_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT02396420_inc_T23",
"arg2_id": "NCT02396420_inc_T24",
"normalized": []
},
{
"id": "NCT02396420_inc_R11",
"type": "Has_value",
"arg1_id": "NCT02396420_inc_T23",
"arg2_id": "NCT02396420_inc_T25",
"normalized": []
},
{
"id": "NCT02396420_inc_R12",
"type": "Has_temporal",
"arg1_id": "NCT02396420_inc_T26",
"arg2_id": "NCT02396420_inc_T27",
"normalized": []
},
{
"id": "NCT02396420_inc_R13",
"type": "Has_value",
"arg1_id": "NCT02396420_inc_T29",
"arg2_id": "NCT02396420_inc_T30",
"normalized": []
},
{
"id": "NCT02396420_inc_R14",
"type": "Has_value",
"arg1_id": "NCT02396420_inc_T26",
"arg2_id": "NCT02396420_inc_T28",
"normalized": []
},
{
"id": "NCT02396420_inc_R15",
"type": "Has_multiplier",
"arg1_id": "NCT02396420_inc_T32",
"arg2_id": "NCT02396420_inc_T31",
"normalized": []
},
{
"id": "NCT02396420_inc_R16",
"type": "Has_temporal",
"arg1_id": "NCT02396420_inc_T34",
"arg2_id": "NCT02396420_inc_T33",
"normalized": []
}
] |
NCT02396732_exc | NCT02396732 | [
{
"id": "NCT02396732_exc_text",
"type": "exclusion",
"text": [
"Presence of VTE upon admission\nPregnant or nursing\nInability to give informed consent by patient or healthcare proxy\nContraindication to enoxaparin\nContraindication to aspirin\nEpidural or subdural hematoma\nPresence, or removal within the last 12 hours, of an epidural or spinal catheter, or recent (within the last 12 hours) epidural or spinal anesthesia/procedures\n"
],
"offsets": [
[
0,
366
]
]
}
] | [
{
"id": "NCT02396732_exc_T1",
"type": "Condition",
"text": [
"VTE"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T2",
"type": "Temporal",
"text": [
"upon admission"
],
"offsets": [
[
16,
30
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T3",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
31,
39
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T4",
"type": "Condition",
"text": [
"nursing"
],
"offsets": [
[
43,
50
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T5",
"type": "Observation",
"text": [
"Inability to give informed consent"
],
"offsets": [
[
51,
85
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T7",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
117,
133
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T8",
"type": "Drug",
"text": [
"enoxaparin"
],
"offsets": [
[
137,
147
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T9",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
148,
164
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T10",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
168,
175
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T11",
"type": "Condition",
"text": [
"ral or s",
"oma\nPres"
],
"offsets": [
[
181,
189
],
[
202,
210
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T12",
"type": "Condition",
"text": [
"subdural hematoma"
],
"offsets": [
[
188,
205
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T13",
"type": "Procedure",
"text": [
"l withi",
"epidural or sp"
],
"offsets": [
[
225,
232
],
[
259,
273
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T14",
"type": "Condition",
"text": [
"ce, or r",
"epidural or sp"
],
"offsets": [
[
212,
220
],
[
259,
273
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T15",
"type": "Temporal",
"text": [
"within the last 12 hours"
],
"offsets": [
[
227,
251
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T16",
"type": "Condition",
"text": [
"ce, or r",
"epid",
" catheter, or "
],
"offsets": [
[
212,
220
],
[
259,
263
],
[
277,
291
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T17",
"type": "Procedure",
"text": [
"l withi",
"epid",
" catheter, or "
],
"offsets": [
[
225,
232
],
[
259,
263
],
[
277,
291
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T18",
"type": "Scope",
"text": [
"ce, or removal withi",
"epidural or spinal catheter, or r"
],
"offsets": [
[
212,
232
],
[
259,
292
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T19",
"type": "Temporal",
"text": [
"recent"
],
"offsets": [
[
291,
297
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T20",
"type": "Temporal",
"text": [
"within the last 12 hours"
],
"offsets": [
[
299,
323
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T21",
"type": "Procedure",
"text": [
"spinal anesthesia"
],
"offsets": [
[
337,
354
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T22",
"type": "Procedure",
"text": [
"al or sp",
"esia/proce"
],
"offsets": [
[
331,
339
],
[
350,
360
]
],
"normalized": []
},
{
"id": "NCT02396732_exc_T23",
"type": "Scope",
"text": [
"epidural or spinal anesthesia"
],
"offsets": [
[
325,
354
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02396732_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02396732_exc_T1",
"arg2_id": "NCT02396732_exc_T2",
"normalized": []
},
{
"id": "NCT02396732_exc_R2",
"type": "AND",
"arg1_id": "NCT02396732_exc_T7",
"arg2_id": "NCT02396732_exc_T8",
"normalized": []
},
{
"id": "NCT02396732_exc_R3",
"type": "AND",
"arg1_id": "NCT02396732_exc_T9",
"arg2_id": "NCT02396732_exc_T10",
"normalized": []
},
{
"id": "NCT02396732_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02396732_exc_T18",
"arg2_id": "NCT02396732_exc_T15",
"normalized": []
},
{
"id": "NCT02396732_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02396732_exc_T19",
"arg2_id": "NCT02396732_exc_T20",
"normalized": []
},
{
"id": "NCT02396732_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT02396732_exc_T23",
"arg2_id": "NCT02396732_exc_T19",
"normalized": []
}
] |
NCT02396732_inc | NCT02396732 | [
{
"id": "NCT02396732_inc_text",
"type": "inclusion",
"text": [
"Age 18 years or older\nBlunt or penetrating trauma\nRequires VTE thromboprophylaxis\nHigh-risk for VTE\n"
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "NCT02396732_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T2",
"type": "Value",
"text": [
"18 years or older"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T3",
"type": "Condition",
"text": [
"penetrating trauma"
],
"offsets": [
[
31,
49
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T4",
"type": "Condition",
"text": [
"lunt",
"rauma"
],
"offsets": [
[
23,
27
],
[
44,
49
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T5",
"type": "Condition",
"text": [
"VTE"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T6",
"type": "Procedure",
"text": [
"thromboprophylaxis"
],
"offsets": [
[
63,
81
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T7",
"type": "Mood",
"text": [
"High-risk"
],
"offsets": [
[
82,
91
]
],
"normalized": []
},
{
"id": "NCT02396732_inc_T8",
"type": "Condition",
"text": [
"VTE"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02396732_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02396732_inc_T1",
"arg2_id": "NCT02396732_inc_T2",
"normalized": []
},
{
"id": "NCT02396732_inc_R2",
"type": "AND",
"arg1_id": "NCT02396732_inc_T6",
"arg2_id": "NCT02396732_inc_T5",
"normalized": []
},
{
"id": "NCT02396732_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT02396732_inc_T8",
"arg2_id": "NCT02396732_inc_T7",
"normalized": []
}
] |
NCT02399033_exc | NCT02399033 | [
{
"id": "NCT02399033_exc_text",
"type": "exclusion",
"text": [
"NA\n\n"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
NCT02399033_inc | NCT02399033 | [
{
"id": "NCT02399033_inc_text",
"type": "inclusion",
"text": [
"Age: 20-70 years old;\nGender: male or female;\nclinical or pathological diagnosis of hepatocellular carcinoma (HCC) in previously untreated patients;\nThe expected survival> 3 months;\nChild-Pugh grade in A-level;\nKPS score with 50-100 points;\nBCLC stage of 0-B;\nconform to the indications of hepatectomy;\nViable tumor resection confirmed by two highly qualified surgical doctors;\nNo other surgical contraindications.\nwomen in the reproductive period must be completely contraception in 28 days before treatment, during the treatment process and in 28 days after treatment;\nMen must be completely contraception and prohibited donation and sperm donation during the treatment process and in 28 days after treatment;\nAll patients must be prohibited donation during the treatment process and in 28 days after treatment;\nIn addition to the subjects, prohibitting other people taking this product.\npatients have a good understanding and could coordinate with investigators for the trial.\nPatients enrolled in the trial should sign an informed consent form, to indicate understanding the purpose and procedure of the trial, and patients volunteering to participate in the trial.\n"
],
"offsets": [
[
0,
1170
]
]
}
] | [
{
"id": "NCT02399033_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T2",
"type": "Value",
"text": [
"20-70 years old"
],
"offsets": [
[
5,
20
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T3",
"type": "Person",
"text": [
"Gender"
],
"offsets": [
[
22,
28
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T4",
"type": "Value",
"text": [
"male"
],
"offsets": [
[
30,
34
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T5",
"type": "Value",
"text": [
"female"
],
"offsets": [
[
38,
44
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T6",
"type": "Scope",
"text": [
"male or female"
],
"offsets": [
[
30,
44
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T8",
"type": "Condition",
"text": [
"hepatocellular carcinoma"
],
"offsets": [
[
84,
108
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T9",
"type": "Qualifier",
"text": [
"clinical or pathological diagnosis"
],
"offsets": [
[
46,
80
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T10",
"type": "Condition",
"text": [
"HCC"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T11",
"type": "Qualifier",
"text": [
"untreated"
],
"offsets": [
[
129,
138
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T7",
"type": "Observation",
"text": [
"expected survival"
],
"offsets": [
[
153,
170
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T12",
"type": "Value",
"text": [
"> 3 months"
],
"offsets": [
[
170,
180
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T13",
"type": "Measurement",
"text": [
"Child-Pugh grade"
],
"offsets": [
[
182,
198
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T14",
"type": "Value",
"text": [
"A"
],
"offsets": [
[
202,
203
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T15",
"type": "Measurement",
"text": [
"KPS score"
],
"offsets": [
[
211,
220
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T16",
"type": "Value",
"text": [
"50-100 points"
],
"offsets": [
[
226,
239
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T17",
"type": "Measurement",
"text": [
"BCLC stage"
],
"offsets": [
[
241,
251
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T18",
"type": "Value",
"text": [
"0-B"
],
"offsets": [
[
255,
258
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T19",
"type": "Procedure",
"text": [
"hepatectomy"
],
"offsets": [
[
290,
301
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T20",
"type": "Observation",
"text": [
"indications of hepatectomy"
],
"offsets": [
[
275,
301
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T22",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
378,
380
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T23",
"type": "Observation",
"text": [
"other surgical contraindications"
],
"offsets": [
[
381,
413
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T24",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
415,
420
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T25",
"type": "Observation",
"text": [
"reproductive period"
],
"offsets": [
[
428,
447
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T26",
"type": "Procedure",
"text": [
"contraception"
],
"offsets": [
[
467,
480
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T27",
"type": "Temporal",
"text": [
"in 28 days before treatment"
],
"offsets": [
[
481,
508
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T28",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
499,
508
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T29",
"type": "Temporal",
"text": [
"during the treatment process"
],
"offsets": [
[
510,
538
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T30",
"type": "Temporal",
"text": [
"in 28 days after treatment"
],
"offsets": [
[
543,
569
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T31",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
521,
530
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T32",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
560,
569
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T33",
"type": "Scope",
"text": [
"in 28 days before treatment, during the treatment process and in 28 days after treatment"
],
"offsets": [
[
481,
569
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T34",
"type": "Person",
"text": [
"Men"
],
"offsets": [
[
571,
574
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T35",
"type": "Procedure",
"text": [
"contraception"
],
"offsets": [
[
594,
607
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T36",
"type": "Negation",
"text": [
"prohibited"
],
"offsets": [
[
612,
622
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T37",
"type": "Procedure",
"text": [
"sperm donation"
],
"offsets": [
[
636,
650
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T38",
"type": "Temporal",
"text": [
"during the treatment process"
],
"offsets": [
[
651,
679
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T39",
"type": "Temporal",
"text": [
"in 28 days after treatment"
],
"offsets": [
[
684,
710
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T40",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
662,
671
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T41",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
701,
710
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T42",
"type": "Scope",
"text": [
"during the treatment process and in 28 days after treatment"
],
"offsets": [
[
651,
710
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T43",
"type": "Procedure",
"text": [
"donation"
],
"offsets": [
[
642,
650
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T44",
"type": "Negation",
"text": [
"prohibited"
],
"offsets": [
[
733,
743
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T45",
"type": "Procedure",
"text": [
"donation"
],
"offsets": [
[
744,
752
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T46",
"type": "Temporal",
"text": [
"during the treatment process"
],
"offsets": [
[
753,
781
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T47",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
764,
773
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T48",
"type": "Temporal",
"text": [
"in 28 days after treatmen"
],
"offsets": [
[
786,
811
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T49",
"type": "Reference_point",
"text": [
"treatment"
],
"offsets": [
[
803,
812
]
],
"normalized": []
},
{
"id": "NCT02399033_inc_T50",
"type": "Scope",
"text": [
"during the treatment process and in 28 days after treatment"
],
"offsets": [
[
753,
812
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02399033_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02399033_inc_T1",
"arg2_id": "NCT02399033_inc_T2",
"normalized": []
},
{
"id": "NCT02399033_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02399033_inc_T3",
"arg2_id": "NCT02399033_inc_T6",
"normalized": []
},
{
"id": "NCT02399033_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT02399033_inc_T8",
"arg2_id": "NCT02399033_inc_T10",
"normalized": []
},
{
"id": "NCT02399033_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02399033_inc_T8",
"arg2_id": "NCT02399033_inc_T9",
"normalized": []
},
{
"id": "NCT02399033_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02399033_inc_T8",
"arg2_id": "NCT02399033_inc_T11",
"normalized": []
},
{
"id": "NCT02399033_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02399033_inc_T7",
"arg2_id": "NCT02399033_inc_T12",
"normalized": []
},
{
"id": "NCT02399033_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02399033_inc_T13",
"arg2_id": "NCT02399033_inc_T14",
"normalized": []
},
{
"id": "NCT02399033_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02399033_inc_T15",
"arg2_id": "NCT02399033_inc_T16",
"normalized": []
},
{
"id": "NCT02399033_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02399033_inc_T17",
"arg2_id": "NCT02399033_inc_T18",
"normalized": []
},
{
"id": "NCT02399033_inc_R11",
"type": "Has_negation",
"arg1_id": "NCT02399033_inc_T23",
"arg2_id": "NCT02399033_inc_T22",
"normalized": []
},
{
"id": "NCT02399033_inc_R12",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T27",
"arg2_id": "NCT02399033_inc_T28",
"normalized": []
},
{
"id": "NCT02399033_inc_R13",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T29",
"arg2_id": "NCT02399033_inc_T31",
"normalized": []
},
{
"id": "NCT02399033_inc_R14",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T30",
"arg2_id": "NCT02399033_inc_T32",
"normalized": []
},
{
"id": "NCT02399033_inc_R15",
"type": "Has_temporal",
"arg1_id": "NCT02399033_inc_T26",
"arg2_id": "NCT02399033_inc_T29",
"normalized": []
},
{
"id": "NCT02399033_inc_R16",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T38",
"arg2_id": "NCT02399033_inc_T40",
"normalized": []
},
{
"id": "NCT02399033_inc_R17",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T39",
"arg2_id": "NCT02399033_inc_T41",
"normalized": []
},
{
"id": "NCT02399033_inc_R18",
"type": "Has_negation",
"arg1_id": "NCT02399033_inc_T37",
"arg2_id": "NCT02399033_inc_T36",
"normalized": []
},
{
"id": "NCT02399033_inc_R19",
"type": "Has_scope",
"arg1_id": "NCT02399033_inc_T35",
"arg2_id": "NCT02399033_inc_T42",
"normalized": []
},
{
"id": "NCT02399033_inc_R20",
"type": "Has_scope",
"arg1_id": "NCT02399033_inc_T37",
"arg2_id": "NCT02399033_inc_T42",
"normalized": []
},
{
"id": "NCT02399033_inc_R21",
"type": "Has_negation",
"arg1_id": "NCT02399033_inc_T43",
"arg2_id": "NCT02399033_inc_T36",
"normalized": []
},
{
"id": "NCT02399033_inc_R22",
"type": "Has_scope",
"arg1_id": "NCT02399033_inc_T43",
"arg2_id": "NCT02399033_inc_T42",
"normalized": []
},
{
"id": "NCT02399033_inc_R23",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T46",
"arg2_id": "NCT02399033_inc_T47",
"normalized": []
},
{
"id": "NCT02399033_inc_R24",
"type": "Has_index",
"arg1_id": "NCT02399033_inc_T48",
"arg2_id": "NCT02399033_inc_T49",
"normalized": []
},
{
"id": "NCT02399033_inc_R25",
"type": "Has_negation",
"arg1_id": "NCT02399033_inc_T45",
"arg2_id": "NCT02399033_inc_T44",
"normalized": []
},
{
"id": "NCT02399033_inc_R26",
"type": "Has_scope",
"arg1_id": "NCT02399033_inc_T45",
"arg2_id": "NCT02399033_inc_T50",
"normalized": []
}
] |
NCT02406495_exc | NCT02406495 | [
{
"id": "NCT02406495_exc_text",
"type": "exclusion",
"text": [
"Is not a habitual wearer of Avaira sphere lenses \nHas a CL prescription outside the range of the available parameters of the study lenses. \nHas a spectacle cylinder ≥1.00D of cylinder in either eye. \nHas a history of not achieving comfortable CL wear (5 days per week; > 8 hours/day) \nHas contact lens best corrected distance vision worse than 20/25 (0.10 logMAR) in either eye. \nPresence of clinically significant (grade 2-4) anterior segment abnormalities \nPresence of ocular or systemic disease or need of medications which might interfere with contact lens wear. \nSlit lamp findings that would contraindicate contact lens wear such as: \nPathological dry eye or associated findings \nPterygium, pinguecula, or corneal scars within the visual axis \nNeovascularization > 0.75 mm in from of the limbus \nGiant papillary conjunctivitis (GCP) worse than grade 1 \nAnterior uveitis or iritis (past or present) \nSeborrheic eczema, Seborrheic conjunctivitis \nHistory of corneal ulcers or fungal infections \nPoor personal hygiene \nHas a known history of corneal hypoesthesia (reduced corneal sensitivity) \nHas aphakia, keratoconus or a highly irregular cornea. \nHas Presbyopia or has dependence on spectacles for near work over the contact lenses. \nHas undergone corneal refractive surgery. \nIs participating in any other type of eye related clinical or research study \n \n"
],
"offsets": [
[
0,
1372
]
]
}
] | [
{
"id": "NCT02406495_exc_T1",
"type": "Device",
"text": [
"Avaira sphere lenses"
],
"offsets": [
[
28,
48
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T2",
"type": "Device",
"text": [
"CL prescription"
],
"offsets": [
[
56,
71
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T5",
"type": "Qualifier",
"text": [
"outside the range of the available parameters of the study lenses"
],
"offsets": [
[
72,
137
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T6",
"type": "Device",
"text": [
"spectacle cylinder"
],
"offsets": [
[
146,
164
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T7",
"type": "Value",
"text": [
"≥1.00D"
],
"offsets": [
[
165,
171
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T8",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
206,
213
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T9",
"type": "Condition",
"text": [
"comfortable CL wear"
],
"offsets": [
[
231,
250
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T10",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
217,
220
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T11",
"type": "Temporal",
"text": [
"5 days per week"
],
"offsets": [
[
252,
267
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T12",
"type": "Temporal",
"text": [
"> 8 hours/day"
],
"offsets": [
[
269,
282
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T13",
"type": "Measurement",
"text": [
"contact lens best corrected distance vision"
],
"offsets": [
[
289,
332
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T14",
"type": "Value",
"text": [
"worse than 20/25",
"in either eye"
],
"offsets": [
[
333,
349
],
[
364,
377
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T15",
"type": "Value",
"text": [
"worse than",
"0.10 logMAR",
"in either eye"
],
"offsets": [
[
333,
343
],
[
351,
362
],
[
364,
377
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T16",
"type": "Scope",
"text": [
"worse than 20/25 (0.10 logMAR) in either eye"
],
"offsets": [
[
333,
377
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T17",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
392,
414
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T19",
"type": "Qualifier",
"text": [
"grade 2-4"
],
"offsets": [
[
416,
425
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T20",
"type": "Value",
"text": [
"2-4"
],
"offsets": [
[
422,
425
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T21",
"type": "Condition",
"text": [
"anterior segment abnormalities"
],
"offsets": [
[
427,
457
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T23",
"type": "Condition",
"text": [
"systemic disease"
],
"offsets": [
[
481,
497
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T24",
"type": "Condition",
"text": [
"ocular",
"disease"
],
"offsets": [
[
471,
477
],
[
490,
497
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T25",
"type": "Condition",
"text": [
"need of medications"
],
"offsets": [
[
501,
520
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T29",
"type": "Qualifier",
"text": [
"might interfere with contact lens wear"
],
"offsets": [
[
527,
565
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T31",
"type": "Scope",
"text": [
"ocular or systemic disease or need of medications"
],
"offsets": [
[
471,
520
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T32",
"type": "Procedure",
"text": [
"Slit lamp"
],
"offsets": [
[
568,
577
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T33",
"type": "Value",
"text": [
"findings"
],
"offsets": [
[
578,
586
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T35",
"type": "Condition",
"text": [
"contraindicate contact lens"
],
"offsets": [
[
598,
625
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T38",
"type": "Condition",
"text": [
"Pathological dry eye"
],
"offsets": [
[
641,
661
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T39",
"type": "Condition",
"text": [
"associated findings"
],
"offsets": [
[
665,
684
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T40",
"type": "Condition",
"text": [
"Pterygium"
],
"offsets": [
[
686,
695
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T41",
"type": "Condition",
"text": [
"pinguecula"
],
"offsets": [
[
697,
707
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T42",
"type": "Condition",
"text": [
"corneal scars"
],
"offsets": [
[
712,
725
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T43",
"type": "Qualifier",
"text": [
"within the visual axis"
],
"offsets": [
[
726,
748
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T44",
"type": "Condition",
"text": [
"Neovascularization"
],
"offsets": [
[
750,
768
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T45",
"type": "Value",
"text": [
"> 0.75 mm in from of the limbus"
],
"offsets": [
[
769,
800
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T46",
"type": "Condition",
"text": [
"Giant papillary conjunctivitis (GCP)"
],
"offsets": [
[
802,
838
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T47",
"type": "Qualifier",
"text": [
"worse than grade 1"
],
"offsets": [
[
839,
857
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T48",
"type": "Condition",
"text": [
"Anterior uveitis"
],
"offsets": [
[
859,
875
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T49",
"type": "Condition",
"text": [
"iritis"
],
"offsets": [
[
879,
885
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T50",
"type": "Temporal",
"text": [
"past"
],
"offsets": [
[
887,
891
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T51",
"type": "Temporal",
"text": [
"present"
],
"offsets": [
[
895,
902
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T52",
"type": "Scope",
"text": [
"past or present"
],
"offsets": [
[
887,
902
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T53",
"type": "Scope",
"text": [
"Anterior uveitis or iritis"
],
"offsets": [
[
859,
885
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T54",
"type": "Condition",
"text": [
"Seborrheic eczema"
],
"offsets": [
[
905,
922
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T55",
"type": "Condition",
"text": [
"Seborrheic conjunctivitis"
],
"offsets": [
[
924,
949
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T56",
"type": "Condition",
"text": [
"corneal ulcers"
],
"offsets": [
[
962,
976
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T57",
"type": "Condition",
"text": [
"fungal infections"
],
"offsets": [
[
980,
997
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T58",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
951,
958
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T59",
"type": "Condition",
"text": [
"Poor personal hygiene"
],
"offsets": [
[
999,
1020
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T60",
"type": "Condition",
"text": [
"corneal hypoesthesia"
],
"offsets": [
[
1045,
1065
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T61",
"type": "Condition",
"text": [
"reduced corneal sensitivity"
],
"offsets": [
[
1067,
1094
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T62",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
1034,
1041
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T63",
"type": "Condition",
"text": [
"aphakia"
],
"offsets": [
[
1101,
1108
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T64",
"type": "Condition",
"text": [
"keratoconus"
],
"offsets": [
[
1110,
1121
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T65",
"type": "Condition",
"text": [
"highly irregular cornea"
],
"offsets": [
[
1127,
1150
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T66",
"type": "Condition",
"text": [
"Presbyopia"
],
"offsets": [
[
1157,
1167
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T67",
"type": "Condition",
"text": [
"dependence on spectacles for near work"
],
"offsets": [
[
1175,
1213
]
],
"normalized": []
},
{
"id": "NCT02406495_exc_T68",
"type": "Procedure",
"text": [
"corneal refractive surgery"
],
"offsets": [
[
1254,
1280
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02406495_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_exc_T2",
"arg2_id": "NCT02406495_exc_T5",
"normalized": []
},
{
"id": "NCT02406495_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02406495_exc_T6",
"arg2_id": "NCT02406495_exc_T7",
"normalized": []
},
{
"id": "NCT02406495_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT02406495_exc_T9",
"arg2_id": "NCT02406495_exc_T10",
"normalized": []
},
{
"id": "NCT02406495_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02406495_exc_T9",
"arg2_id": "NCT02406495_exc_T8",
"normalized": []
},
{
"id": "NCT02406495_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02406495_exc_T14",
"arg2_id": "NCT02406495_exc_T15",
"normalized": []
},
{
"id": "NCT02406495_exc_R6",
"type": "Has_scope",
"arg1_id": "NCT02406495_exc_T13",
"arg2_id": "NCT02406495_exc_T16",
"normalized": []
},
{
"id": "NCT02406495_exc_R7",
"type": "Has_value",
"arg1_id": "NCT02406495_exc_T19",
"arg2_id": "NCT02406495_exc_T20",
"normalized": []
},
{
"id": "NCT02406495_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT02406495_exc_T17",
"arg2_id": "NCT02406495_exc_T19",
"normalized": []
},
{
"id": "NCT02406495_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_exc_T21",
"arg2_id": "NCT02406495_exc_T17",
"normalized": []
},
{
"id": "NCT02406495_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_exc_T31",
"arg2_id": "NCT02406495_exc_T29",
"normalized": []
},
{
"id": "NCT02406495_exc_R11",
"type": "Has_value",
"arg1_id": "NCT02406495_exc_T32",
"arg2_id": "NCT02406495_exc_T33",
"normalized": []
},
{
"id": "NCT02406495_exc_R12",
"type": "AND",
"arg1_id": "NCT02406495_exc_T32",
"arg2_id": "NCT02406495_exc_T35",
"normalized": []
},
{
"id": "NCT02406495_exc_R13",
"type": "AND",
"arg1_id": "NCT02406495_exc_T39",
"arg2_id": "NCT02406495_exc_T38",
"normalized": []
},
{
"id": "NCT02406495_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_exc_T42",
"arg2_id": "NCT02406495_exc_T43",
"normalized": []
},
{
"id": "NCT02406495_exc_R15",
"type": "Has_value",
"arg1_id": "NCT02406495_exc_T44",
"arg2_id": "NCT02406495_exc_T45",
"normalized": []
},
{
"id": "NCT02406495_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_exc_T46",
"arg2_id": "NCT02406495_exc_T47",
"normalized": []
},
{
"id": "NCT02406495_exc_R17",
"type": "Has_scope",
"arg1_id": "NCT02406495_exc_T53",
"arg2_id": "NCT02406495_exc_T52",
"normalized": []
},
{
"id": "NCT02406495_exc_R18",
"type": "Has_temporal",
"arg1_id": "NCT02406495_exc_T57",
"arg2_id": "NCT02406495_exc_T58",
"normalized": []
},
{
"id": "NCT02406495_exc_R19",
"type": "Has_temporal",
"arg1_id": "NCT02406495_exc_T56",
"arg2_id": "NCT02406495_exc_T58",
"normalized": []
},
{
"id": "NCT02406495_exc_R20",
"type": "Subsumes",
"arg1_id": "NCT02406495_exc_T60",
"arg2_id": "NCT02406495_exc_T61",
"normalized": []
},
{
"id": "NCT02406495_exc_R21",
"type": "Has_temporal",
"arg1_id": "NCT02406495_exc_T60",
"arg2_id": "NCT02406495_exc_T62",
"normalized": []
}
] |
NCT02406495_inc | NCT02406495 | [
{
"id": "NCT02406495_inc_text",
"type": "inclusion",
"text": [
"Is between 18 and 40 years of age (inclusive) \nHas had a self-reported visual exam in the last two years \nIs an adapted Avaira sphere contact lens wearer (at least 1 week in Avaira sphere) \nHas a contact lens spherical prescription between + 2.25 to - 8.00 (inclusive) \nHas a spectacle cylinder up to 0.75D in each eye. \nCan achieve best corrected spectacle distance visual acuity of 20/25 (0.10 logMAR) or better in each eye. \nCan achieve a distance visual acuity of 20/30 (0.18 logMAR) or better in each eye with the study contact lenses. \nHas clear corneas and no active ocular disease \nHas read, understood and signed the information consent letter. \nPatient contact lens refraction should fit within the available parameters of the study lenses. \nIs willing to comply with the wear schedule (at least 5 days per week, > 8 hours/day assuming there are no contraindications for doing so). \nIs willing to comply with the visit schedule \n"
],
"offsets": [
[
0,
939
]
]
}
] | [
{
"id": "NCT02406495_inc_T1",
"type": "Value",
"text": [
"between 18 and 40 years",
"(inclusive)"
],
"offsets": [
[
3,
26
],
[
34,
45
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T3",
"type": "Procedure",
"text": [
"self-reported visual exam"
],
"offsets": [
[
57,
82
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T4",
"type": "Temporal",
"text": [
"in the last two years"
],
"offsets": [
[
83,
104
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T5",
"type": "Device",
"text": [
"Avaira sphere contact lens"
],
"offsets": [
[
120,
146
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T6",
"type": "Temporal",
"text": [
"at least 1 week in Avaira sphere"
],
"offsets": [
[
155,
187
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T7",
"type": "Reference_point",
"text": [
"Avaira sphere"
],
"offsets": [
[
174,
187
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T8",
"type": "Device",
"text": [
"Avaira sphere"
],
"offsets": [
[
174,
187
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T9",
"type": "Device",
"text": [
"contact lens"
],
"offsets": [
[
196,
208
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T10",
"type": "Value",
"text": [
"+ 2.25 to - 8.00 (inclusive)"
],
"offsets": [
[
240,
268
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T11",
"type": "Qualifier",
"text": [
"spherical"
],
"offsets": [
[
209,
218
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T12",
"type": "Device",
"text": [
"spectacle cylinder"
],
"offsets": [
[
276,
294
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T13",
"type": "Value",
"text": [
"up to 0.75D"
],
"offsets": [
[
295,
306
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T14",
"type": "Measurement",
"text": [
"best corrected spectacle distance visual acuity"
],
"offsets": [
[
333,
380
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T15",
"type": "Value",
"text": [
"20/25",
"or better"
],
"offsets": [
[
384,
389
],
[
404,
413
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T16",
"type": "Value",
"text": [
"0.10 logMAR",
"or better"
],
"offsets": [
[
391,
402
],
[
404,
413
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T17",
"type": "Measurement",
"text": [
"distance visual acuity"
],
"offsets": [
[
442,
464
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T18",
"type": "Value",
"text": [
"20/30",
"or better"
],
"offsets": [
[
468,
473
],
[
488,
497
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T19",
"type": "Value",
"text": [
"0.18 logMAR",
"or better"
],
"offsets": [
[
475,
486
],
[
488,
497
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T20",
"type": "Device",
"text": [
"study contact lenses"
],
"offsets": [
[
519,
539
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T21",
"type": "Condition",
"text": [
"clear corneas"
],
"offsets": [
[
546,
559
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T22",
"type": "Condition",
"text": [
"ocular disease"
],
"offsets": [
[
574,
588
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T23",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
564,
566
]
],
"normalized": []
},
{
"id": "NCT02406495_inc_T24",
"type": "Temporal",
"text": [
"active"
],
"offsets": [
[
567,
573
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02406495_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T2",
"arg2_id": "NCT02406495_inc_T1",
"normalized": []
},
{
"id": "NCT02406495_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT02406495_inc_T3",
"arg2_id": "NCT02406495_inc_T4",
"normalized": []
},
{
"id": "NCT02406495_inc_R3",
"type": "Has_index",
"arg1_id": "NCT02406495_inc_T6",
"arg2_id": "NCT02406495_inc_T7",
"normalized": []
},
{
"id": "NCT02406495_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT02406495_inc_T5",
"arg2_id": "NCT02406495_inc_T6",
"normalized": []
},
{
"id": "NCT02406495_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT02406495_inc_T9",
"arg2_id": "NCT02406495_inc_T11",
"normalized": []
},
{
"id": "NCT02406495_inc_R6",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T9",
"arg2_id": "NCT02406495_inc_T10",
"normalized": []
},
{
"id": "NCT02406495_inc_R7",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T12",
"arg2_id": "NCT02406495_inc_T13",
"normalized": []
},
{
"id": "NCT02406495_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT02406495_inc_T15",
"arg2_id": "NCT02406495_inc_T16",
"normalized": []
},
{
"id": "NCT02406495_inc_R9",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T14",
"arg2_id": "NCT02406495_inc_T15",
"normalized": []
},
{
"id": "NCT02406495_inc_R10",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T17",
"arg2_id": "NCT02406495_inc_T18",
"normalized": []
},
{
"id": "NCT02406495_inc_R11",
"type": "AND",
"arg1_id": "NCT02406495_inc_T17",
"arg2_id": "NCT02406495_inc_T20",
"normalized": []
},
{
"id": "NCT02406495_inc_R12",
"type": "Has_value",
"arg1_id": "NCT02406495_inc_T17",
"arg2_id": "NCT02406495_inc_T19",
"normalized": []
},
{
"id": "NCT02406495_inc_R13",
"type": "Has_temporal",
"arg1_id": "NCT02406495_inc_T22",
"arg2_id": "NCT02406495_inc_T24",
"normalized": []
},
{
"id": "NCT02406495_inc_R14",
"type": "Has_negation",
"arg1_id": "NCT02406495_inc_T22",
"arg2_id": "NCT02406495_inc_T23",
"normalized": []
}
] |
NCT02406885_exc | NCT02406885 | [
{
"id": "NCT02406885_exc_text",
"type": "exclusion",
"text": [
"History of documented clotting/coagulation disorder\nHistory of cancer (within the last year)\nAny diagnosis requiring anti-coagulation\nHistory of hypersensitivity reaction to apixaban\nActive clinically significant bleeding\nCreatinine > 1.5 mg/dL\nParticipants currently receiving any type of anticoagulation or blood thinning medications, including heparin, low molecular weight heparins, Plavix, aspirin, NSAIDS\nCombined P-glycoprotein and strong cytochrome P450 (CYP) 3A4 inhibitor\nCombined P-glycoprotein and moderate CYP 3A4 inhibitor\nCombined P-glycoprotein inducer and strong CYP 3A4 inducer\nInducers of p-glycoprotein\nStrong inducers of CYP 3A4\n"
],
"offsets": [
[
0,
650
]
]
}
] | [
{
"id": "NCT02406885_exc_T1",
"type": "Condition",
"text": [
"coagulation disorder"
],
"offsets": [
[
31,
51
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T2",
"type": "Condition",
"text": [
"clotting",
"disorder"
],
"offsets": [
[
22,
30
],
[
43,
51
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T3",
"type": "Condition",
"text": [
"cancer"
],
"offsets": [
[
63,
69
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T4",
"type": "Temporal",
"text": [
"last year"
],
"offsets": [
[
82,
91
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T5",
"type": "Drug",
"text": [
"anti-coagulation"
],
"offsets": [
[
117,
133
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T6",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
145,
161
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T7",
"type": "Drug",
"text": [
"apixaban"
],
"offsets": [
[
174,
182
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T8",
"type": "Condition",
"text": [
"bleeding"
],
"offsets": [
[
213,
221
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T9",
"type": "Qualifier",
"text": [
"significant"
],
"offsets": [
[
201,
212
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T10",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
183,
189
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T11",
"type": "Measurement",
"text": [
"Creatinine"
],
"offsets": [
[
222,
232
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T12",
"type": "Value",
"text": [
"> 1.5 mg/dL"
],
"offsets": [
[
233,
244
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T13",
"type": "Drug",
"text": [
"anticoagulation"
],
"offsets": [
[
290,
305
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T14",
"type": "Drug",
"text": [
"blood thinning medications"
],
"offsets": [
[
309,
335
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T15",
"type": "Drug",
"text": [
"heparin"
],
"offsets": [
[
347,
354
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T16",
"type": "Drug",
"text": [
"low molecular weight heparins"
],
"offsets": [
[
356,
385
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T17",
"type": "Drug",
"text": [
"Plavix"
],
"offsets": [
[
387,
393
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T18",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
395,
402
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T19",
"type": "Drug",
"text": [
"NSAIDS"
],
"offsets": [
[
404,
410
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T20",
"type": "Scope",
"text": [
"anticoagulation or blood thinning medications"
],
"offsets": [
[
290,
335
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T21",
"type": "Scope",
"text": [
"heparin, low molecular weight heparins, Plavix, aspirin, NSAIDS"
],
"offsets": [
[
347,
410
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T22",
"type": "Drug",
"text": [
"protein and st",
"or\nCombin"
],
"offsets": [
[
427,
441
],
[
479,
488
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T23",
"type": "Drug",
"text": [
"ome P450 (CYP)",
"ibitor\nCombin"
],
"offsets": [
[
453,
467
],
[
475,
488
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T24",
"type": "Qualifier",
"text": [
"strong"
],
"offsets": [
[
439,
445
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T25",
"type": "Drug",
"text": [
"rotein and mod",
"r\nCombine"
],
"offsets": [
[
499,
513
],
[
535,
544
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T26",
"type": "Drug",
"text": [
"CYP 3A4 inhibitor"
],
"offsets": [
[
519,
536
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T27",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
510,
518
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T28",
"type": "Drug",
"text": [
"P-glycoprotein inducer"
],
"offsets": [
[
546,
568
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T29",
"type": "Drug",
"text": [
"CYP 3A4 inducer"
],
"offsets": [
[
580,
595
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T30",
"type": "Qualifier",
"text": [
"strong"
],
"offsets": [
[
573,
579
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T31",
"type": "Drug",
"text": [
"Inducers of p-glycoprotein"
],
"offsets": [
[
596,
622
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T32",
"type": "Drug",
"text": [
"inducers of CYP 3A4"
],
"offsets": [
[
630,
649
]
],
"normalized": []
},
{
"id": "NCT02406885_exc_T33",
"type": "Qualifier",
"text": [
"Strong"
],
"offsets": [
[
623,
629
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02406885_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT02406885_exc_T3",
"arg2_id": "NCT02406885_exc_T4",
"normalized": []
},
{
"id": "NCT02406885_exc_R2",
"type": "AND",
"arg1_id": "NCT02406885_exc_T6",
"arg2_id": "NCT02406885_exc_T7",
"normalized": []
},
{
"id": "NCT02406885_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T8",
"arg2_id": "NCT02406885_exc_T9",
"normalized": []
},
{
"id": "NCT02406885_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T8",
"arg2_id": "NCT02406885_exc_T10",
"normalized": []
},
{
"id": "NCT02406885_exc_R5",
"type": "Has_value",
"arg1_id": "NCT02406885_exc_T11",
"arg2_id": "NCT02406885_exc_T12",
"normalized": []
},
{
"id": "NCT02406885_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02406885_exc_T20",
"arg2_id": "NCT02406885_exc_T21",
"normalized": []
},
{
"id": "NCT02406885_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T23",
"arg2_id": "NCT02406885_exc_T24",
"normalized": []
},
{
"id": "NCT02406885_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T26",
"arg2_id": "NCT02406885_exc_T27",
"normalized": []
},
{
"id": "NCT02406885_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T29",
"arg2_id": "NCT02406885_exc_T30",
"normalized": []
},
{
"id": "NCT02406885_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT02406885_exc_T32",
"arg2_id": "NCT02406885_exc_T33",
"normalized": []
}
] |
NCT02406885_inc | NCT02406885 | [
{
"id": "NCT02406885_inc_text",
"type": "inclusion",
"text": [
"Men or women, 18 to 65 years old with a BMI of 35 kg/m2 or greater who will be undergoing bariatric surgery (VSG and RYGB)\nSigned written informed consent\nWomen of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours prior to the start of study drug\nWomen must not be breastfeeding\n"
],
"offsets": [
[
0,
384
]
]
}
] | [
{
"id": "NCT02406885_inc_T1",
"type": "Person",
"text": [
"Men"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
7,
12
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T3",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T4",
"type": "Value",
"text": [
"18 to 65 years"
],
"offsets": [
[
14,
28
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T5",
"type": "Measurement",
"text": [
"BMI"
],
"offsets": [
[
40,
43
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T6",
"type": "Value",
"text": [
"35 kg/m2 or greater"
],
"offsets": [
[
47,
66
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T7",
"type": "Procedure",
"text": [
"bariatric surgery"
],
"offsets": [
[
90,
107
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T8",
"type": "Procedure",
"text": [
"VSG"
],
"offsets": [
[
109,
112
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T9",
"type": "Procedure",
"text": [
"RYGB"
],
"offsets": [
[
117,
121
]
],
"normalized": []
},
{
"id": "NCT02406885_inc_T10",
"type": "Scope",
"text": [
"VSG and RYGB"
],
"offsets": [
[
109,
121
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02406885_inc_R1",
"type": "Has_value",
"arg1_id": "NCT02406885_inc_T3",
"arg2_id": "NCT02406885_inc_T4",
"normalized": []
},
{
"id": "NCT02406885_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02406885_inc_T5",
"arg2_id": "NCT02406885_inc_T6",
"normalized": []
},
{
"id": "NCT02406885_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT02406885_inc_T7",
"arg2_id": "NCT02406885_inc_T10",
"normalized": []
}
] |
NCT02408120_exc | NCT02408120 | [
{
"id": "NCT02408120_exc_text",
"type": "exclusion",
"text": [
"NA\n\n"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
NCT02408120_inc | NCT02408120 | [
{
"id": "NCT02408120_inc_text",
"type": "inclusion",
"text": [
"Subjects admitted to the hospital with acute or chronic medical illnesses or for elective and emergency surgical illness or trauma\nKnown history of Type 2 diabetes mellitus for >3 months\nTreated with either diet alone, any combination of oral antidiabetic agents, non-insulin injectables or insulin therapy\nBlood glucose levels between >140 mg and <400 mg/dL without laboratory evidence of diabetic ketoacidosis\n"
],
"offsets": [
[
0,
412
]
]
}
] | [
{
"id": "NCT02408120_inc_T1",
"type": "Observation",
"text": [
"admitted to the hospital"
],
"offsets": [
[
9,
33
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T2",
"type": "Condition",
"text": [
"medical illnesses"
],
"offsets": [
[
56,
73
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T3",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
48,
55
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T4",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T5",
"type": "Scope",
"text": [
"acute or chronic"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T6",
"type": "Condition",
"text": [
"surgical illness"
],
"offsets": [
[
104,
120
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T7",
"type": "Condition",
"text": [
"trauma"
],
"offsets": [
[
124,
130
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T8",
"type": "Qualifier",
"text": [
"emergency"
],
"offsets": [
[
94,
103
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T9",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
81,
89
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T10",
"type": "Scope",
"text": [
"elective and emergency"
],
"offsets": [
[
81,
103
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T12",
"type": "Scope",
"text": [
"surgical illness or trauma"
],
"offsets": [
[
104,
130
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T13",
"type": "Condition",
"text": [
"Type 2 diabetes mellitus"
],
"offsets": [
[
148,
172
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T14",
"type": "Value",
"text": [
">3 months"
],
"offsets": [
[
177,
186
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T15",
"type": "Procedure",
"text": [
"diet"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T16",
"type": "Drug",
"text": [
"oral antidiabetic agents"
],
"offsets": [
[
238,
262
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T17",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
291,
298
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T18",
"type": "Drug",
"text": [
"n-insulin injectables o",
"erapy\nB"
],
"offsets": [
[
266,
289
],
[
301,
308
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T19",
"type": "Measurement",
"text": [
"Blood glucose levels"
],
"offsets": [
[
307,
327
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T20",
"type": "Value",
"text": [
">140 mg and <400 mg/dL"
],
"offsets": [
[
336,
358
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T21",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
359,
366
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T22",
"type": "Qualifier",
"text": [
"laboratory evidence"
],
"offsets": [
[
367,
386
]
],
"normalized": []
},
{
"id": "NCT02408120_inc_T23",
"type": "Condition",
"text": [
"diabetic ketoacidosis"
],
"offsets": [
[
390,
411
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02408120_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT02408120_inc_T2",
"arg2_id": "NCT02408120_inc_T5",
"normalized": []
},
{
"id": "NCT02408120_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT02408120_inc_T12",
"arg2_id": "NCT02408120_inc_T10",
"normalized": []
},
{
"id": "NCT02408120_inc_R3",
"type": "AND",
"arg1_id": "NCT02408120_inc_T1",
"arg2_id": "NCT02408120_inc_T2",
"normalized": []
},
{
"id": "NCT02408120_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT02408120_inc_T1",
"arg2_id": "NCT02408120_inc_T12",
"normalized": []
},
{
"id": "NCT02408120_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02408120_inc_T13",
"arg2_id": "NCT02408120_inc_T14",
"normalized": []
},
{
"id": "NCT02408120_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT02408120_inc_T23",
"arg2_id": "NCT02408120_inc_T22",
"normalized": []
},
{
"id": "NCT02408120_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT02408120_inc_T23",
"arg2_id": "NCT02408120_inc_T21",
"normalized": []
},
{
"id": "NCT02408120_inc_R8",
"type": "Has_value",
"arg1_id": "NCT02408120_inc_T19",
"arg2_id": "NCT02408120_inc_T20",
"normalized": []
}
] |
NCT02413970_exc | NCT02413970 | [
{
"id": "NCT02413970_exc_text",
"type": "exclusion",
"text": [
"Central + mixed apneas > 25% of the total apnea-hypopnea index (AHI)\nAny anatomical finding that would compromise the performance of upper airway stimulation, such as the presence of complete concentric collapse of the soft palate\nAny condition or procedure that has compromised neurological control of the upper airway\nPatients who are unable or do not have the necessary assistance to operate the patient remote\nPatients who are pregnant or plan to become pregnant\nPatients who will require magnetic resonance imaging (MRI)\nPatients with an implantable device that may be susceptible to unintended interaction with the Inspire system.\nBody Mass Index (BMI) of > 32\nAny chronic medical illness or condition that contraindicates a surgical procedure under general anesthesia, as judged by the clinical study Investigator\nHas a terminal illness with life expectancy < 12 months\nActive psychiatric disease (psychotic illness, major depression, or acute anxiety attacks) which prevents subject compliance with the requirements of the investigational study testing\nAny other reason the investigator deems subject is unfit for participation in the study\n"
],
"offsets": [
[
0,
1149
]
]
}
] | [
{
"id": "NCT02413970_exc_T1",
"type": "Condition",
"text": [
"mixed apneas"
],
"offsets": [
[
10,
22
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T2",
"type": "Condition",
"text": [
"Central",
"apneas"
],
"offsets": [
[
0,
7
],
[
16,
22
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T3",
"type": "Value",
"text": [
"> 25%"
],
"offsets": [
[
23,
28
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T4",
"type": "Measurement",
"text": [
"total apnea-hypopnea index"
],
"offsets": [
[
36,
62
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T5",
"type": "Measurement",
"text": [
"AHI"
],
"offsets": [
[
64,
67
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T6",
"type": "Scope",
"text": [
"Central + mixed apneas"
],
"offsets": [
[
0,
22
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T11",
"type": "Procedure",
"text": [
"magnetic resonance imaging"
],
"offsets": [
[
493,
519
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T12",
"type": "Procedure",
"text": [
"MRI"
],
"offsets": [
[
521,
524
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T14",
"type": "Measurement",
"text": [
"Body Mass Index"
],
"offsets": [
[
637,
652
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T15",
"type": "Measurement",
"text": [
"BMI"
],
"offsets": [
[
654,
657
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T16",
"type": "Value",
"text": [
"> 32"
],
"offsets": [
[
662,
666
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T17",
"type": "Condition",
"text": [
"contraindicates"
],
"offsets": [
[
713,
728
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T18",
"type": "Procedure",
"text": [
"surgical procedure"
],
"offsets": [
[
731,
749
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T19",
"type": "Procedure",
"text": [
"general anesthesia"
],
"offsets": [
[
756,
774
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T20",
"type": "Observation",
"text": [
"life expectancy"
],
"offsets": [
[
849,
864
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T21",
"type": "Value",
"text": [
"< 12 months"
],
"offsets": [
[
865,
876
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T22",
"type": "Condition",
"text": [
"psychiatric disease"
],
"offsets": [
[
884,
903
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T23",
"type": "Condition",
"text": [
"psychotic illness"
],
"offsets": [
[
905,
922
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T24",
"type": "Condition",
"text": [
"major depression"
],
"offsets": [
[
924,
940
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T25",
"type": "Condition",
"text": [
"acute anxiety attacks"
],
"offsets": [
[
945,
966
]
],
"normalized": []
},
{
"id": "NCT02413970_exc_T26",
"type": "Scope",
"text": [
"psychotic illness, major depression, or acute anxiety attacks"
],
"offsets": [
[
905,
966
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02413970_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT02413970_exc_T4",
"arg2_id": "NCT02413970_exc_T5",
"normalized": []
},
{
"id": "NCT02413970_exc_R2",
"type": "Has_value",
"arg1_id": "NCT02413970_exc_T4",
"arg2_id": "NCT02413970_exc_T3",
"normalized": []
},
{
"id": "NCT02413970_exc_R3",
"type": "AND",
"arg1_id": "NCT02413970_exc_T6",
"arg2_id": "NCT02413970_exc_T4",
"normalized": []
},
{
"id": "NCT02413970_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT02413970_exc_T11",
"arg2_id": "NCT02413970_exc_T12",
"normalized": []
},
{
"id": "NCT02413970_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT02413970_exc_T14",
"arg2_id": "NCT02413970_exc_T15",
"normalized": []
},
{
"id": "NCT02413970_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT02413970_exc_T14",
"arg2_id": "NCT02413970_exc_T16",
"normalized": []
},
{
"id": "NCT02413970_exc_R7",
"type": "AND",
"arg1_id": "NCT02413970_exc_T17",
"arg2_id": "NCT02413970_exc_T18",
"normalized": []
},
{
"id": "NCT02413970_exc_R8",
"type": "AND",
"arg1_id": "NCT02413970_exc_T18",
"arg2_id": "NCT02413970_exc_T19",
"normalized": []
},
{
"id": "NCT02413970_exc_R9",
"type": "Has_value",
"arg1_id": "NCT02413970_exc_T20",
"arg2_id": "NCT02413970_exc_T21",
"normalized": []
},
{
"id": "NCT02413970_exc_R10",
"type": "Has_scope",
"arg1_id": "NCT02413970_exc_T22",
"arg2_id": "NCT02413970_exc_T26",
"normalized": []
}
] |
NCT02413970_inc | NCT02413970 | [
{
"id": "NCT02413970_inc_text",
"type": "inclusion",
"text": [
"Likely suffer moderate-to-severe OSA based on history and physical or have an established diagnosis of OSA (20=AHI=65) based on a prior in-lab Polysomnography\nDocumentation the subject not effectively treated with CPAP therapy. (Examples include non-compliance, discomfort, undesirable side effects, symptoms persist despite use). Subjects who have been prescribed, but refuse to try CPAP would be considered intolerant.\nAge 22 or above\nWilling and capable to have stimulation hardware permanently implanted, and to use the patient remote to activate the stimulation\nWilling and capable to return for all follow-up visits and conduct sleep studies at home, including the evaluation procedures and filling out questionnaires\nWilling and capable of providing informed consent\n"
],
"offsets": [
[
0,
774
]
]
}
] | [
{
"id": "NCT02413970_inc_T1",
"type": "Condition",
"text": [
"OSA"
],
"offsets": [
[
33,
36
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T2",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
14,
22
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T3",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
26,
32
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T4",
"type": "Scope",
"text": [
"moderate-to-severe"
],
"offsets": [
[
14,
32
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T5",
"type": "Condition",
"text": [
"OSA"
],
"offsets": [
[
103,
106
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T6",
"type": "Measurement",
"text": [
"AHI"
],
"offsets": [
[
111,
114
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T7",
"type": "Value",
"text": [
"20",
"=65"
],
"offsets": [
[
108,
110
],
[
114,
117
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T8",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
185,
188
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T9",
"type": "Procedure",
"text": [
"CPAP therapy"
],
"offsets": [
[
214,
226
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T10",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
421,
424
]
],
"normalized": []
},
{
"id": "NCT02413970_inc_T11",
"type": "Value",
"text": [
"22 or above"
],
"offsets": [
[
425,
436
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT02413970_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT02413970_inc_T1",
"arg2_id": "NCT02413970_inc_T4",
"normalized": []
},
{
"id": "NCT02413970_inc_R2",
"type": "Has_value",
"arg1_id": "NCT02413970_inc_T6",
"arg2_id": "NCT02413970_inc_T7",
"normalized": []
},
{
"id": "NCT02413970_inc_R3",
"type": "AND",
"arg1_id": "NCT02413970_inc_T5",
"arg2_id": "NCT02413970_inc_T6",
"normalized": []
},
{
"id": "NCT02413970_inc_R4",
"type": "Has_negation",
"arg1_id": "NCT02413970_inc_T9",
"arg2_id": "NCT02413970_inc_T8",
"normalized": []
},
{
"id": "NCT02413970_inc_R5",
"type": "Has_value",
"arg1_id": "NCT02413970_inc_T10",
"arg2_id": "NCT02413970_inc_T11",
"normalized": []
}
] |