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DS.d723
18687985
[ { "id": "DS.d723.s0", "type": "", "text": [ "Studies suggest that DKK1 activation in osteoblasts is the underlying cause of glucocorticoid- and estrogen deficiency-mediated osteoporosis, and at least partially underlies the teratogenic effects of thalidomide on limb development." ], "offsets": [ [ 0, 234 ] ] } ]
[ { "id": "DS.d723.s0.e0", "type": "protein", "text": [ "DKK1" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94907" } ] }, { "id": "DS.d723.s0.e1", "type": "compound", "text": [ "thalidomide" ], "offsets": [ [ 202, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5426" }, { "db_name": "PubChem", "db_id": "75792" }, { "db_name": "PubChem", "db_id": "92142" } ] } ]
[]
[]
[ { "id": "DS.d723.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d723.s0.e1", "arg2_id": "DS.d723.s0.e0", "normalized": [] } ]
DS.d724
18688040
[ { "id": "DS.d724.s0", "type": "", "text": [ "The IL-13-induced up-regulation of RhoA was inhibited by leflunomide, an inhibitor of signal transducer and activator of transcription 6 (STAT6)." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "DS.d724.s0.e0", "type": "protein", "text": [ "IL-13" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20109" }, { "db_name": "UniProt", "db_id": "P35225" }, { "db_name": "UniProt", "db_id": "P42203" }, { "db_name": "UniProt", "db_id": "P61126" }, { "db_name": "UniProt", "db_id": "Q5I6E4" }, { "db_name": "UniProt", "db_id": "Q864V6" }, { "db_name": "UniProt", "db_id": "Q865W5" }, { "db_name": "UniProt", "db_id": "Q865X3" }, { "db_name": "UniProt", "db_id": "Q95J68" }, { "db_name": "UniProt", "db_id": "Q9N0W9" }, { "db_name": "UniProt", "db_id": "Q9XSV9" } ] }, { "id": "DS.d724.s0.e1", "type": "protein", "text": [ "RhoA" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9C3Y4" } ] }, { "id": "DS.d724.s0.e2", "type": "compound", "text": [ "leflunomide" ], "offsets": [ [ 57, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3899" } ] }, { "id": "DS.d724.s0.e3", "type": "protein", "text": [ "STAT6" ], "offsets": [ [ 138, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42226" } ] } ]
[]
[]
[ { "id": "DS.d724.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d724.s0.e2", "arg2_id": "DS.d724.s0.e1", "normalized": [] }, { "id": "DS.d724.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d724.s0.e2", "arg2_id": "DS.d724.s0.e3", "normalized": [] } ]
DS.d725
18688042
[ { "id": "DS.d725.s0", "type": "", "text": [ "The goal of this study was to determine the mechanisms by which 17beta-estradiol induces MUC5B gene expression in airway epithelial cells." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d725.s1", "type": "", "text": [ "Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression." ], "offsets": [ [ 139, 256 ] ] } ]
[ { "id": "DS.d725.s0.e0", "type": "compound", "text": [ "17beta-estradiol" ], "offsets": [ [ 64, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d725.s0.e1", "type": "protein", "text": [ "MUC5B" ], "offsets": [ [ 89, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9HC84" } ] }, { "id": "DS.d725.s1.e0", "type": "compound", "text": [ "ICI 182,780" ], "offsets": [ [ 171, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104741" } ] }, { "id": "DS.d725.s1.e1", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d725.s1.e2", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 214, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d725.s1.e3", "type": "protein", "text": [ "MUC5B" ], "offsets": [ [ 234, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9HC84" } ] } ]
[]
[]
[ { "id": "DS.d725.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d725.s0.e0", "arg2_id": "DS.d725.s0.e1", "normalized": [] }, { "id": "DS.d725.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d725.s1.e0", "arg2_id": "DS.d725.s1.e1", "normalized": [] }, { "id": "DS.d725.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d725.s1.e0", "arg2_id": "DS.d725.s1.e2", "normalized": [] }, { "id": "DS.d725.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d725.s1.e0", "arg2_id": "DS.d725.s1.e3", "normalized": [] } ]
DS.d726
18688696
[ { "id": "DS.d726.s0", "type": "", "text": [ "We here show that calumenin in the presence of Ca(2+) binds to TSP1 with a dissociation constant K (d) around 0.4 muM." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "DS.d726.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d726.s0.e1", "type": "protein", "text": [ "TSP1" ], "offsets": [ [ 63, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07996" }, { "db_name": "UniProt", "db_id": "P54000" }, { "db_name": "UniProt", "db_id": "Q28178" } ] } ]
[]
[]
[ { "id": "DS.d726.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d726.s0.e0", "arg2_id": "DS.d726.s0.e1", "normalized": [] } ]
DS.d727
18688816
[ { "id": "DS.d727.s0", "type": "", "text": [ "It represents transition in sulfur-deprived conditions, known to lead to H2 production in Chlamydomonas reinhardtii, and the two main processes then induced which are an over-accumulation of intracellular starch and a progressive reduction of PSII activity for anoxia achievement." ], "offsets": [ [ 0, 280 ] ] } ]
[ { "id": "DS.d727.s0.e0", "type": "compound", "text": [ "sulfur" ], "offsets": [ [ 28, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "402" } ] }, { "id": "DS.d727.s0.e1", "type": "protein", "text": [ "PSII" ], "offsets": [ [ 243, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O47040" }, { "db_name": "UniProt", "db_id": "O78462" }, { "db_name": "UniProt", "db_id": "O96813" }, { "db_name": "UniProt", "db_id": "P12185" }, { "db_name": "UniProt", "db_id": "P12186" }, { "db_name": "UniProt", "db_id": "P12187" }, { "db_name": "UniProt", "db_id": "P13165" }, { "db_name": "UniProt", "db_id": "P17227" }, { "db_name": "UniProt", "db_id": "P17228" }, { "db_name": "UniProt", "db_id": "P28251" }, { "db_name": "UniProt", "db_id": "P30980" }, { "db_name": "UniProt", "db_id": "P48116" }, { "db_name": "UniProt", "db_id": "P49159" }, { "db_name": "UniProt", "db_id": "P49484" }, { "db_name": "UniProt", "db_id": "P51387" }, { "db_name": "UniProt", "db_id": "P52768" }, { "db_name": "UniProt", "db_id": "P56768" }, { "db_name": "UniProt", "db_id": "P58214" }, { "db_name": "UniProt", "db_id": "P69396" }, { "db_name": "UniProt", "db_id": "P69397" }, { "db_name": "UniProt", "db_id": "P69398" }, { "db_name": "UniProt", "db_id": "Q31909" }, { "db_name": "UniProt", "db_id": "Q5QA78" }, { "db_name": "UniProt", "db_id": "Q5SCW1" }, { "db_name": "UniProt", "db_id": "Q68RZ6" }, { "db_name": "UniProt", "db_id": "Q6B8K8" }, { "db_name": "UniProt", "db_id": "Q6ENG4" }, { "db_name": "UniProt", "db_id": "Q6ENV4" }, { "db_name": "UniProt", "db_id": "Q6EW69" }, { "db_name": "UniProt", "db_id": "Q6L390" }, { "db_name": "UniProt", "db_id": "Q6L603" }, { "db_name": "UniProt", "db_id": "Q6QBN9" }, { "db_name": "UniProt", "db_id": "Q70XZ3" }, { "db_name": "UniProt", "db_id": "Q7FNS8" }, { "db_name": "UniProt", "db_id": "Q7YJW3" }, { "db_name": "UniProt", "db_id": "Q85CI4" }, { "db_name": "UniProt", "db_id": "Q85FL2" }, { "db_name": "UniProt", "db_id": "Q85X26" }, { "db_name": "UniProt", "db_id": "Q8M9X5" }, { "db_name": "UniProt", "db_id": "Q8WI10" }, { "db_name": "UniProt", "db_id": "Q9BBS0" }, { "db_name": "UniProt", "db_id": "Q9GDV2" }, { "db_name": "UniProt", "db_id": "Q9MTL2" }, { "db_name": "UniProt", "db_id": "Q9MUQ4" }, { "db_name": "UniProt", "db_id": "Q9TL12" }, { "db_name": "UniProt", "db_id": "Q9TM24" } ] } ]
[]
[]
[ { "id": "DS.d727.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d727.s0.e0", "arg2_id": "DS.d727.s0.e1", "normalized": [] } ]
DS.d728
18689429
[ { "id": "DS.d728.s0", "type": "", "text": [ "We examined whether aldosterone produced locally in the brain may contribute to the activation of mineralocorticoid receptors in the CNS." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "DS.d728.s0.e0", "type": "compound", "text": [ "aldosterone" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5839" } ] }, { "id": "DS.d728.s0.e1", "type": "protein", "text": [ "mineralocorticoid receptors" ], "offsets": [ [ 98, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08235" }, { "db_name": "UniProt", "db_id": "P22199" }, { "db_name": "UniProt", "db_id": "P79404" }, { "db_name": "UniProt", "db_id": "Q29131" }, { "db_name": "UniProt", "db_id": "Q3YC04" }, { "db_name": "UniProt", "db_id": "Q4JM28" }, { "db_name": "UniProt", "db_id": "Q8QHI2" }, { "db_name": "UniProt", "db_id": "Q8VII8" }, { "db_name": "UniProt", "db_id": "Q91573" }, { "db_name": "UniProt", "db_id": "Q9BDJ7" }, { "db_name": "UniProt", "db_id": "Q9IAC6" }, { "db_name": "UniProt", "db_id": "Q9N0W8" } ] } ]
[]
[]
[ { "id": "DS.d728.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d728.s0.e0", "arg2_id": "DS.d728.s0.e1", "normalized": [] } ]
DS.d729
18690415
[ { "id": "DS.d729.s0", "type": "", "text": [ "Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression." ], "offsets": [ [ 0, 343 ] ] } ]
[ { "id": "DS.d729.s0.e0", "type": "compound", "text": [ "iron dextran" ], "offsets": [ [ 130, 142 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "105075" } ] }, { "id": "DS.d729.s0.e1", "type": "protein", "text": [ "Hamp" ], "offsets": [ [ 322, 326 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7T273" }, { "db_name": "UniProt", "db_id": "Q99MH3" }, { "db_name": "UniProt", "db_id": "Q9EQ21" } ] } ]
[]
[]
[ { "id": "DS.d729.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d729.s0.e0", "arg2_id": "DS.d729.s0.e1", "normalized": [] } ]
DS.d730
18690549
[ { "id": "DS.d730.s0", "type": "", "text": [ "Rat dicarboxylate transporter (SDCT1), expressed in renal tubular epithelial cells, plays a key role in regulating blood and urinary citrate level by reabsorbing citrate from the lumen." ], "offsets": [ [ 0, 185 ] ] } ]
[ { "id": "DS.d730.s0.e0", "type": "protein", "text": [ "SDCT1" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13183" }, { "db_name": "UniProt", "db_id": "Q28615" } ] }, { "id": "DS.d730.s0.e1", "type": "compound", "text": [ "citrate" ], "offsets": [ [ 133, 140 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "311" }, { "db_name": "PubChem", "db_id": "2733526" } ] }, { "id": "DS.d730.s0.e2", "type": "compound", "text": [ "citrate" ], "offsets": [ [ 162, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "311" }, { "db_name": "PubChem", "db_id": "2733526" } ] } ]
[]
[]
[ { "id": "DS.d730.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d730.s0.e1", "arg2_id": "DS.d730.s0.e0", "normalized": [] } ]
DS.d731
18690792
[ { "id": "DS.d731.s0", "type": "", "text": [ "However, as opposed to exogenous HS, the continuous use of FGF-2 during in vitro differentiation completely blocked rMSC mineralization." ], "offsets": [ [ 0, 136 ] ] }, { "id": "DS.d731.s1", "type": "", "text": [ "We show that the effects of both FGF-2 and HS are mediated through FGF receptor 1 (FGFR1) and that inhibition of signaling through this receptor arrests cell growth, resulting in the cells being unable to reach the critical density necessary to induce differentiation." ], "offsets": [ [ 137, 405 ] ] } ]
[ { "id": "DS.d731.s0.e0", "type": "compound", "text": [ "HS" ], "offsets": [ [ 33, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5047209" }, { "db_name": "PubChem", "db_id": "46173182" } ] }, { "id": "DS.d731.s0.e1", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d731.s1.e0", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 170, 175 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d731.s1.e1", "type": "compound", "text": [ "HS" ], "offsets": [ [ 180, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5047209" }, { "db_name": "PubChem", "db_id": "46173182" } ] }, { "id": "DS.d731.s1.e2", "type": "protein", "text": [ "FGF" ], "offsets": [ [ 170, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O10284" }, { "db_name": "UniProt", "db_id": "P41444" } ] }, { "id": "DS.d731.s1.e3", "type": "protein", "text": [ "FGFR1" ], "offsets": [ [ 220, 225 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11362" }, { "db_name": "UniProt", "db_id": "P21804" }, { "db_name": "UniProt", "db_id": "Q8MY86" }, { "db_name": "UniProt", "db_id": "Q91285" } ] } ]
[]
[]
[ { "id": "DS.d731.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d731.s1.e1", "arg2_id": "DS.d731.s1.e3", "normalized": [] } ]
DS.d732
18691156
[ { "id": "DS.d732.s0", "type": "", "text": [ "Two related polytopic membrane proteins of the major facilitator family, NarK and NarU, catalyse nitrate uptake, nitrite export and nitrite uptake across the Escherichia coli cytoplasmic membrane by an unknown mechanism." ], "offsets": [ [ 0, 220 ] ] } ]
[ { "id": "DS.d732.s0.e0", "type": "protein", "text": [ "membrane proteins" ], "offsets": [ [ 22, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16629" }, { "db_name": "UniProt", "db_id": "P24266" }, { "db_name": "UniProt", "db_id": "P28991" }, { "db_name": "UniProt", "db_id": "Q04565" }, { "db_name": "UniProt", "db_id": "Q07252" } ] }, { "id": "DS.d732.s0.e1", "type": "protein", "text": [ "NarK" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10903" }, { "db_name": "UniProt", "db_id": "P46907" } ] }, { "id": "DS.d732.s0.e2", "type": "protein", "text": [ "NarU" ], "offsets": [ [ 82, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P37593" }, { "db_name": "UniProt", "db_id": "P37758" } ] }, { "id": "DS.d732.s0.e3", "type": "compound", "text": [ "nitrate" ], "offsets": [ [ 97, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "943" } ] } ]
[]
[]
[ { "id": "DS.d732.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d732.s0.e3", "arg2_id": "DS.d732.s0.e2", "normalized": [] }, { "id": "DS.d732.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d732.s0.e3", "arg2_id": "DS.d732.s0.e1", "normalized": [] } ]
DS.d733
18691343
[ { "id": "DS.d733.s0", "type": "", "text": [ "Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry." ], "offsets": [ [ 0, 205 ] ] } ]
[ { "id": "DS.d733.s0.e0", "type": "protein", "text": [ "interferon-gamma" ], "offsets": [ [ 47, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] }, { "id": "DS.d733.s0.e1", "type": "protein", "text": [ "Th1" ], "offsets": [ [ 65, 68 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q64279" }, { "db_name": "UniProt", "db_id": "Q922L6" } ] }, { "id": "DS.d733.s0.e2", "type": "compound", "text": [ "phorbol 12-myristate 13-acetate" ], "offsets": [ [ 138, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4792" }, { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d733.s0.e3", "type": "compound", "text": [ "ionomycin" ], "offsets": [ [ 174, 183 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3733" }, { "db_name": "PubChem", "db_id": "6434517" }, { "db_name": "PubChem", "db_id": "6912226" }, { "db_name": "PubChem", "db_id": "25134244" } ] } ]
[]
[]
[ { "id": "DS.d733.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d733.s0.e3", "arg2_id": "DS.d733.s0.e0", "normalized": [] }, { "id": "DS.d733.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d733.s0.e2", "arg2_id": "DS.d733.s0.e1", "normalized": [] }, { "id": "DS.d733.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d733.s0.e2", "arg2_id": "DS.d733.s0.e0", "normalized": [] }, { "id": "DS.d733.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d733.s0.e3", "arg2_id": "DS.d733.s0.e1", "normalized": [] } ]
DS.d734
18691603
[ { "id": "DS.d734.s0", "type": "", "text": [ "This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB2) cannabinoid receptors." ], "offsets": [ [ 0, 240 ] ] } ]
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[]
[]
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DS.d735
18691715
[ { "id": "DS.d735.s0", "type": "", "text": [ "Homocysteine stimulates antioxidant response element-mediated expression of glutamate-cysteine ligase in mouse macrophages." ], "offsets": [ [ 0, 123 ] ] }, { "id": "DS.d735.s1", "type": "", "text": [ "The current study investigated whether homocysteine induces transcription of glutamate-cysteine ligase (Gcl), via ARE driven gene expression in mouse macrophages." ], "offsets": [ [ 124, 286 ] ] }, { "id": "DS.d735.s2", "type": "", "text": [ "Treatment of mouse macrophages with d-/l-homocysteine (50microM) induced depletion of intracellular glutathione and a compensatory increase in Gcl activity." ], "offsets": [ [ 287, 443 ] ] }, { "id": "DS.d735.s3", "type": "", "text": [ "Real-time RT-PCR revealed increased mRNA-expression of the catalytic subunit of Gcl (Gclc) after treatment with homocysteine, and this occurred via increased transcription as demonstrated with luciferase promoter reporter constructs for Gclc." ], "offsets": [ [ 444, 686 ] ] } ]
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}, { "db_name": "UniProt", "db_id": "Q8X0X0" }, { "db_name": "UniProt", "db_id": "Q8X900" }, { "db_name": "UniProt", "db_id": "Q8XK30" }, { "db_name": "UniProt", "db_id": "Q8Y3R3" }, { "db_name": "UniProt", "db_id": "Q8Z4D6" }, { "db_name": "UniProt", "db_id": "Q8ZBU2" }, { "db_name": "UniProt", "db_id": "Q926X7" }, { "db_name": "UniProt", "db_id": "Q97IV1" }, { "db_name": "UniProt", "db_id": "Q9CM00" }, { "db_name": "UniProt", "db_id": "Q9HF78" }, { "db_name": "UniProt", "db_id": "Q9HTY6" }, { "db_name": "UniProt", "db_id": "Q9KUG5" }, { "db_name": "UniProt", "db_id": "Q9NFN6" }, { "db_name": "UniProt", "db_id": "Q9W3K5" } ] }, { "id": "DS.d735.s1.e0", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 163, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d735.s1.e1", "type": "protein", "text": [ "glutamate-cysteine ligase" ], "offsets": [ [ 201, 226 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O68838" }, { "db_name": "UniProt", "db_id": "P0A6W9" }, { "db_name": "UniProt", "db_id": "P0A6X0" }, { "db_name": "UniProt", "db_id": "P32477" }, { "db_name": "UniProt", "db_id": "P57485" }, { "db_name": "UniProt", "db_id": "P58994" }, { "db_name": "UniProt", "db_id": "P61379" }, { "db_name": "UniProt", "db_id": "Q09768" }, { "db_name": "UniProt", "db_id": "Q20117" }, { "db_name": "UniProt", "db_id": "Q57KV3" }, { "db_name": "UniProt", "db_id": "Q5E7F8" }, { "db_name": "UniProt", "db_id": "Q5LYY5" }, { "db_name": "UniProt", "db_id": "Q5M3J8" }, { "db_name": "UniProt", "db_id": "Q5PF10" }, { "db_name": "UniProt", "db_id": "Q65RX0" }, { "db_name": "UniProt", "db_id": "Q66E64" }, { "db_name": "UniProt", "db_id": "Q6ANW2" }, { "db_name": "UniProt", "db_id": "Q6D1T4" }, { "db_name": "UniProt", "db_id": "Q6LMV1" }, { "db_name": "UniProt", "db_id": "Q71VZ1" }, { "db_name": "UniProt", "db_id": "Q72RD4" }, { "db_name": "UniProt", "db_id": "Q7MHS5" }, { "db_name": "UniProt", "db_id": "Q7N7A4" }, { "db_name": "UniProt", "db_id": "Q7W3F2" }, { "db_name": "UniProt", "db_id": "Q7WES2" }, { "db_name": "UniProt", "db_id": "Q82ZG8" }, { "db_name": "UniProt", "db_id": "Q87LS2" }, { "db_name": "UniProt", "db_id": "Q88AR1" }, { "db_name": "UniProt", "db_id": "Q88R90" }, { "db_name": "UniProt", "db_id": "Q88UW5" }, { "db_name": "UniProt", "db_id": "Q89AD8" }, { "db_name": "UniProt", "db_id": "Q8D2V5" }, { "db_name": "UniProt", "db_id": "Q8DC38" }, { "db_name": "UniProt", "db_id": "Q8DW15" }, { "db_name": "UniProt", "db_id": "Q8DXM9" }, { "db_name": "UniProt", "db_id": "Q8E399" }, { "db_name": "UniProt", "db_id": "Q8EBF9" }, { "db_name": "UniProt", "db_id": "Q8F4D5" }, { "db_name": "UniProt", "db_id": "Q8X0X0" }, { "db_name": "UniProt", "db_id": "Q8X900" }, { "db_name": "UniProt", "db_id": "Q8XK30" }, { "db_name": "UniProt", "db_id": "Q8Y3R3" }, { "db_name": "UniProt", "db_id": "Q8Z4D6" }, { "db_name": "UniProt", "db_id": "Q8ZBU2" }, { "db_name": "UniProt", "db_id": "Q926X7" }, { "db_name": "UniProt", "db_id": "Q97IV1" }, { "db_name": "UniProt", "db_id": "Q9CM00" }, { "db_name": "UniProt", "db_id": "Q9HF78" }, { "db_name": "UniProt", "db_id": "Q9HTY6" }, { "db_name": "UniProt", "db_id": "Q9KUG5" }, { "db_name": "UniProt", "db_id": "Q9NFN6" }, { "db_name": "UniProt", "db_id": "Q9W3K5" } ] }, { "id": "DS.d735.s1.e2", "type": "protein", "text": [ "Gcl" ], "offsets": [ [ 228, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AEP7" }, { "db_name": "UniProt", "db_id": "P0AEP8" }, { "db_name": "UniProt", "db_id": "Q01820" }, { "db_name": "UniProt", "db_id": "Q920G9" } ] }, { "id": "DS.d735.s2.e0", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 328, 340 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d735.s2.e1", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 387, 398 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d735.s2.e2", "type": "protein", "text": [ "Gcl" ], "offsets": [ [ 430, 433 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AEP7" }, { "db_name": "UniProt", "db_id": "P0AEP8" }, { "db_name": "UniProt", "db_id": "Q01820" }, { "db_name": "UniProt", "db_id": "Q920G9" } ] }, { "id": "DS.d735.s3.e0", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 556, 568 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d735.s3.e1", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 637, 647 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[ { "id": "DS.d735.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d735.s0.e0", "arg2_id": "DS.d735.s0.e1", "normalized": [] }, { "id": "DS.d735.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d735.s2.e0", "arg2_id": "DS.d735.s2.e2", "normalized": [] } ]
DS.d736
18691757
[ { "id": "DS.d736.s0", "type": "", "text": [ "Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "DS.d736.s0.e0", "type": "protein", "text": [ "Flt3" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00342" } ] }, { "id": "DS.d736.s0.e1", "type": "compound", "text": [ "idarubicin" ], "offsets": [ [ 109, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "42890" } ] } ]
[]
[]
[ { "id": "DS.d736.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d736.s0.e1", "arg2_id": "DS.d736.s0.e0", "normalized": [] } ]
DS.d737
18692155
[ { "id": "DS.d737.s0", "type": "", "text": [ "Only EGF activated ERK signaling and up-regulated early gene expression, while DHT triggered the expression of classical AR-responsive genes with the exception of the EGF-induced PSA transcript in A549 cells." ], "offsets": [ [ 0, 208 ] ] }, { "id": "DS.d737.s1", "type": "", "text": [ "DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells, while in LNCaP cells each mitogen increased only CD1 protein expression." ], "offsets": [ [ 209, 368 ] ] } ]
[ { "id": "DS.d737.s0.e0", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 5, 8 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "P26224" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d737.s0.e1", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d737.s0.e2", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d737.s0.e3", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 167, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "P26224" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d737.s0.e4", "type": "protein", "text": [ "PSA" ], "offsets": [ [ 179, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07288" }, { "db_name": "UniProt", "db_id": "P10658" }, { "db_name": "UniProt", "db_id": "P33619" }, { "db_name": "UniProt", "db_id": "P55786" }, { "db_name": "UniProt", "db_id": "Q11011" }, { "db_name": "UniProt", "db_id": "Q6DT45" }, { "db_name": "UniProt", "db_id": "Q9Y617" } ] }, { "id": "DS.d737.s1.e0", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 209, 212 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d737.s1.e1", "type": "protein", "text": [ "EGF" ], "offsets": [ [ 217, 220 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01132" }, { "db_name": "UniProt", "db_id": "P01133" }, { "db_name": "UniProt", "db_id": "P07522" }, { "db_name": "UniProt", "db_id": "P26224" }, { "db_name": "UniProt", "db_id": "Q00968" }, { "db_name": "UniProt", "db_id": "Q95ND4" }, { "db_name": "UniProt", "db_id": "Q9BEA0" } ] }, { "id": "DS.d737.s1.e2", "type": "protein", "text": [ "CD1" ], "offsets": [ [ 244, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23043" } ] }, { "id": "DS.d737.s1.e3", "type": "protein", "text": [ "CD1" ], "offsets": [ [ 345, 348 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23043" } ] } ]
[]
[]
[ { "id": "DS.d737.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d737.s1.e0", "arg2_id": "DS.d737.s1.e2", "normalized": [] } ]
DS.d738
18692592
[ { "id": "DS.d738.s0", "type": "", "text": [ "High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway." ], "offsets": [ [ 0, 185 ] ] }, { "id": "DS.d738.s1", "type": "", "text": [ "The influence of the prenylation status of Ras on the observed changes in endothelial cell growth under high glucose conditions has not previously been examined." ], "offsets": [ [ 186, 347 ] ] } ]
[ { "id": "DS.d738.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 5, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d738.s0.e1", "type": "protein", "text": [ "TGFbeta1" ], "offsets": [ [ 90, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19011" }, { "db_name": "UniProt", "db_id": "O93449" }, { "db_name": "UniProt", "db_id": "P01137" }, { "db_name": "UniProt", "db_id": "P04202" }, { "db_name": "UniProt", "db_id": "P07200" }, { "db_name": "UniProt", "db_id": "P09531" }, { "db_name": "UniProt", "db_id": "P09533" }, { "db_name": "UniProt", "db_id": "P16176" }, { "db_name": "UniProt", "db_id": "P17246" }, { "db_name": "UniProt", "db_id": "P18341" }, { "db_name": "UniProt", "db_id": "P50414" }, { "db_name": "UniProt", "db_id": "P54831" }, { "db_name": "UniProt", "db_id": "Q38HS2" }, { "db_name": "UniProt", "db_id": "Q9PTQ2" }, { "db_name": "UniProt", "db_id": "Q9Z1Y6" } ] }, { "id": "DS.d738.s0.e2", "type": "protein", "text": [ "Ras" ], "offsets": [ [ 127, 130 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03967" }, { "db_name": "UniProt", "db_id": "P22126" }, { "db_name": "UniProt", "db_id": "Q07152" } ] }, { "id": "DS.d738.s1.e0", "type": "protein", "text": [ "Ras" ], "offsets": [ [ 229, 232 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03967" }, { "db_name": "UniProt", "db_id": "P22126" }, { "db_name": "UniProt", "db_id": "Q07152" } ] }, { "id": "DS.d738.s1.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 295, 302 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d738.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d738.s0.e0", "arg2_id": "DS.d738.s0.e1", "normalized": [] }, { "id": "DS.d738.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d738.s0.e0", "arg2_id": "DS.d738.s0.e2", "normalized": [] } ]
DS.d739
18692599
[ { "id": "DS.d739.s0", "type": "", "text": [ "Calcineurin inhibitors (CsA, FK-506 and pimecrolimus) inhibited NO production and iNOS expression in a concentration-dependent manner, CsA being more potent than FK-506 and pimecrolimus." ], "offsets": [ [ 0, 186 ] ] }, { "id": "DS.d739.s1", "type": "", "text": [ "In conclusion, the results suggest that calcineurin inhibitors cyclosporin A, tacrolimus (FK-506) and pimecrolimus inhibit iNOS expression and NO production in response to inflammatory stimuli by enhancing the decay of iNOS mRNA by a 3'UTR-dependent manner." ], "offsets": [ [ 187, 444 ] ] } ]
[ { "id": "DS.d739.s0.e1", "type": "compound", "text": [ "FK-506" ], "offsets": [ [ 29, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6436007" } ] }, { "id": "DS.d739.s0.e2", "type": "compound", "text": [ "pimecrolimus" ], "offsets": [ [ 40, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6447131" }, { "db_name": "PubChem", "db_id": "6509979" }, { "db_name": "PubChem", "db_id": "17753757" }, { "db_name": "PubChem", "db_id": "24847863" }, { "db_name": "PubChem", "db_id": "53394893" }, { "db_name": "PubChem", "db_id": "53486290" } ] }, { "id": "DS.d739.s0.e3", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 82, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d739.s0.e4", "type": "compound", "text": [ "FK-506" ], "offsets": [ [ 162, 168 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6436007" } ] }, { "id": "DS.d739.s0.e5", "type": "compound", "text": [ "pimecrolimus" ], "offsets": [ [ 173, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6447131" }, { "db_name": "PubChem", "db_id": "6509979" }, { "db_name": "PubChem", "db_id": "17753757" }, { "db_name": "PubChem", "db_id": "24847863" }, { "db_name": "PubChem", "db_id": "53394893" }, { "db_name": "PubChem", "db_id": "53486290" } ] }, { "id": "DS.d739.s1.e1", "type": "compound", "text": [ "cyclosporin A" ], "offsets": [ [ 250, 263 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2909" }, { "db_name": "PubChem", "db_id": "5280754" }, { "db_name": "PubChem", "db_id": "5284373" }, { "db_name": "PubChem", "db_id": "5458585" }, { "db_name": "PubChem", "db_id": "5497195" }, { "db_name": "PubChem", "db_id": "6435893" }, { "db_name": "PubChem", "db_id": "24883466" }, { "db_name": "PubChem", "db_id": "49867938" } ] }, { "id": "DS.d739.s1.e2", "type": "compound", "text": [ "tacrolimus" ], "offsets": [ [ 265, 275 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5372" }, { "db_name": "PubChem", "db_id": "445643" }, { "db_name": "PubChem", "db_id": "445647" }, { "db_name": "PubChem", "db_id": "6426916" }, { "db_name": "PubChem", "db_id": "6436007" }, { "db_name": "PubChem", "db_id": "6473866" }, { "db_name": "PubChem", "db_id": "6536850" }, { "db_name": "PubChem", "db_id": "9940643" }, { "db_name": "PubChem", "db_id": "23581796" }, { "db_name": "PubChem", "db_id": "54611630" } ] }, { "id": "DS.d739.s1.e3", "type": "compound", "text": [ "FK-506" ], "offsets": [ [ 277, 283 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6436007" } ] }, { "id": "DS.d739.s1.e4", "type": "compound", "text": [ "pimecrolimus" ], "offsets": [ [ 289, 301 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6447131" }, { "db_name": "PubChem", "db_id": "6509979" }, { "db_name": "PubChem", "db_id": "17753757" }, { "db_name": "PubChem", "db_id": "24847863" }, { "db_name": "PubChem", "db_id": "53394893" }, { "db_name": "PubChem", "db_id": "53486290" } ] }, { "id": "DS.d739.s1.e5", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d739.s1.e6", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 406, 410 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] } ]
[]
[]
[ { "id": "DS.d739.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s0.e1", "arg2_id": "DS.d739.s0.e3", "normalized": [] }, { "id": "DS.d739.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s0.e2", "arg2_id": "DS.d739.s0.e3", "normalized": [] }, { "id": "DS.d739.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s1.e4", "arg2_id": "DS.d739.s1.e5", "normalized": [] }, { "id": "DS.d739.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s1.e1", "arg2_id": "DS.d739.s1.e5", "normalized": [] }, { "id": "DS.d739.s1.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s1.e2", "arg2_id": "DS.d739.s1.e5", "normalized": [] }, { "id": "DS.d739.s1.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d739.s1.e3", "arg2_id": "DS.d739.s1.e5", "normalized": [] } ]
DS.d740
18692849
[ { "id": "DS.d740.s0", "type": "", "text": [ "An increased activity of ATP-binding cassette transporter A1 (ABCA1) and ABCG5/G8 heterodimer has been proposed as a mechanism underlying the hypocholesterolaemic effect of phytosterols." ], "offsets": [ [ 0, 186 ] ] } ]
[ { "id": "DS.d740.s0.e0", "type": "protein", "text": [ "ABCA1" ], "offsets": [ [ 62, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95477" } ] }, { "id": "DS.d740.s0.e1", "type": "protein", "text": [ "ABCG5" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9H222" } ] }, { "id": "DS.d740.s0.e2", "type": "compound", "text": [ "phytosterols" ], "offsets": [ [ 173, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12303662" } ] } ]
[]
[]
[ { "id": "DS.d740.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d740.s0.e2", "arg2_id": "DS.d740.s0.e0", "normalized": [] }, { "id": "DS.d740.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d740.s0.e2", "arg2_id": "DS.d740.s0.e1", "normalized": [] } ]
DS.d741
18692896
[ { "id": "DS.d741.s0", "type": "", "text": [ "In sum, copper exposure lowered TOSC, a result that at least in part can be related to lowering of antioxidant enzymes like CAT." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "DS.d741.s0.e0", "type": "compound", "text": [ "copper" ], "offsets": [ [ 8, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d741.s0.e1", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] } ]
[]
[]
[ { "id": "DS.d741.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d741.s0.e0", "arg2_id": "DS.d741.s0.e1", "normalized": [] } ]
DS.d742
18693051
[ { "id": "DS.d742.s0", "type": "", "text": [ "Accumulation of glucose in PA was increased by insulin at 10nM and by IGF-I at 1 nM and 10nM." ], "offsets": [ [ 0, 93 ] ] } ]
[ { "id": "DS.d742.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 16, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d742.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 47, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d742.s0.e2", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] } ]
[]
[]
[ { "id": "DS.d742.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d742.s0.e0", "arg2_id": "DS.d742.s0.e1", "normalized": [] }, { "id": "DS.d742.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d742.s0.e0", "arg2_id": "DS.d742.s0.e2", "normalized": [] } ]
DS.d743
18693094
[ { "id": "DS.d743.s0", "type": "", "text": [ "Glucagon is important to this response because it increases glutamine uptake." ], "offsets": [ [ 0, 77 ] ] } ]
[ { "id": "DS.d743.s0.e0", "type": "protein", "text": [ "Glucagon" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "O42143" }, { "db_name": "UniProt", "db_id": "O42144" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P04093" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P07449" }, { "db_name": "UniProt", "db_id": "P09566" }, { "db_name": "UniProt", "db_id": "P09567" }, { "db_name": "UniProt", "db_id": "P09682" }, { "db_name": "UniProt", "db_id": "P09686" }, { "db_name": "UniProt", "db_id": "P0C235" }, { "db_name": "UniProt", "db_id": "P13189" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P18108" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P31297" }, { "db_name": "UniProt", "db_id": "P33528" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "P68260" }, { "db_name": "UniProt", "db_id": "P68273" }, { "db_name": "UniProt", "db_id": "P68274" }, { "db_name": "UniProt", "db_id": "P68275" }, { "db_name": "UniProt", "db_id": "P68952" }, { "db_name": "UniProt", "db_id": "P68953" }, { "db_name": "UniProt", "db_id": "P68954" }, { "db_name": "UniProt", "db_id": "P68955" }, { "db_name": "UniProt", "db_id": "P68956" }, { "db_name": "UniProt", "db_id": "P68957" }, { "db_name": "UniProt", "db_id": "P79695" }, { "db_name": "UniProt", "db_id": "P81880" }, { "db_name": "UniProt", "db_id": "Q8MJ25" }, { "db_name": "UniProt", "db_id": "Q9PRQ9" } ] }, { "id": "DS.d743.s0.e1", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 60, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] } ]
[]
[]
[ { "id": "DS.d743.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d743.s0.e1", "arg2_id": "DS.d743.s0.e0", "normalized": [] } ]
DS.d744
18693095
[ { "id": "DS.d744.s0", "type": "", "text": [ "It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1)." ], "offsets": [ [ 0, 180 ] ] } ]
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[]
[]
[]
DS.d745
18693100
[ { "id": "DS.d745.s0", "type": "", "text": [ "Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats." ], "offsets": [ [ 0, 203 ] ] } ]
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[]
[]
[]
DS.d746
18693294
[ { "id": "DS.d746.s0", "type": "", "text": [ "The activity of guanylyl cyclase was determined by the amount of cGMP generated in responses to sodium nitroprusside (SNP) or ANP." ], "offsets": [ [ 0, 130 ] ] } ]
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[]
[]
[ { "id": "DS.d746.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d746.s0.e1", "arg2_id": "DS.d746.s0.e0", "normalized": [] } ]
DS.d747
18694296
[ { "id": "DS.d747.s0", "type": "", "text": [ "Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression." ], "offsets": [ [ 0, 232 ] ] } ]
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[]
[]
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DS.d748
18694429
[ { "id": "DS.d748.s0", "type": "", "text": [ "Immunolocalization of androgen receptor in the boar epididymis: the effect of GnRH agonist deslorelin." ], "offsets": [ [ 0, 102 ] ] } ]
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[]
[]
[]
DS.d749
18694845
[ { "id": "DS.d749.s0", "type": "", "text": [ "E(2) increased the expression of caveolin-1 and caveolin-2 mRNA and proteins, but pre-treatment with ICI 182,780 (an estrogen receptor (ER) antagonist) inhibited E(2)-induced increase in caveolin-1 and caveolin-2 proteins expression." ], "offsets": [ [ 0, 233 ] ] }, { "id": "DS.d749.s1", "type": "", "text": [ "Phospho-caveolin-1 was significantly blocked by ICI 182,780 or pyrazolopyrimidine 2 (PP2 ; a Src-kinase inhibitor)." ], "offsets": [ [ 234, 349 ] ] }, { "id": "DS.d749.s2", "type": "", "text": [ "LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying ((3)H)-thymidine incorporation." ], "offsets": [ [ 350, 522 ] ] }, { "id": "DS.d749.s3", "type": "", "text": [ "Furthermore, inhibition of caveolin-1 expression using a caveolin-1 siRNA significantly attenuated E(2)-induced up-regulation of proto-oncogenes, cell cycle regulatory proteins, ((3)H)-thymidine incorporation, overall cell number, and percent of the cell population in S phase, while mediating a concomitant increase in the G0/G1 population." ], "offsets": [ [ 523, 864 ] ] } ]
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"db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d749.s0.e1", "type": "protein", "text": [ "caveolin-2" ], "offsets": [ [ 48, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46550" }, { "db_name": "UniProt", "db_id": "P51636" }, { "db_name": "UniProt", "db_id": "Q07DW0" }, { "db_name": "UniProt", "db_id": "Q07DX2" }, { "db_name": "UniProt", "db_id": "Q07DZ3" }, { 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"UniProt", "db_id": "Q2QLG7" }, { "db_name": "UniProt", "db_id": "Q2QLH8" }, { "db_name": "UniProt", "db_id": "Q66WT7" }, { "db_name": "UniProt", "db_id": "Q9WVC3" }, { "db_name": "UniProt", "db_id": "Q9YGM9" } ] }, { "id": "DS.d749.s0.e2", "type": "compound", "text": [ "ICI 182,780" ], "offsets": [ [ 101, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104741" } ] }, { "id": "DS.d749.s0.e3", "type": "protein", "text": [ "caveolin-1" ], "offsets": [ [ 187, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33724" }, { "db_name": "UniProt", "db_id": "P35431" }, { "db_name": "UniProt", "db_id": "P41350" }, { "db_name": "UniProt", "db_id": "P49817" }, { "db_name": "UniProt", "db_id": "P79132" }, { "db_name": "UniProt", "db_id": "Q03135" }, { "db_name": "UniProt", "db_id": "Q07DV9" }, { "db_name": "UniProt", "db_id": "Q07DX1" }, { "db_name": "UniProt", "db_id": "Q07DY2" }, { "db_name": "UniProt", "db_id": "Q07DZ2" }, { "db_name": "UniProt", "db_id": "Q07E02" }, { "db_name": "UniProt", "db_id": "Q07E25" }, { "db_name": "UniProt", "db_id": "Q07E38" }, { "db_name": "UniProt", "db_id": "Q07E49" }, { "db_name": "UniProt", "db_id": "Q09YH8" }, { "db_name": "UniProt", "db_id": "Q09YK1" }, { "db_name": "UniProt", "db_id": "Q09YN6" }, { "db_name": "UniProt", "db_id": "Q108U7" }, { "db_name": "UniProt", "db_id": "Q2IBA5" }, { "db_name": "UniProt", "db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d749.s0.e4", "type": "protein", "text": [ "caveolin-2" ], "offsets": [ [ 202, 212 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46550" }, { "db_name": "UniProt", "db_id": "P51636" }, { "db_name": "UniProt", "db_id": "Q07DW0" }, { "db_name": "UniProt", "db_id": "Q07DX2" }, { "db_name": "UniProt", "db_id": "Q07DZ3" }, { "db_name": "UniProt", "db_id": "Q07E26" }, { "db_name": "UniProt", "db_id": "Q07E39" }, { "db_name": "UniProt", "db_id": "Q07E50" }, { "db_name": "UniProt", "db_id": "Q09YH9" }, { "db_name": "UniProt", "db_id": "Q09YJ1" }, { "db_name": "UniProt", "db_id": "Q09YK2" }, { "db_name": "UniProt", "db_id": "Q09YL4" }, { "db_name": "UniProt", "db_id": "Q09YN7" }, { "db_name": "UniProt", "db_id": "Q108U8" }, { "db_name": "UniProt", "db_id": "Q18879" }, { "db_name": "UniProt", "db_id": "Q2IBA4" }, { "db_name": "UniProt", "db_id": "Q2IBC2" }, { "db_name": "UniProt", "db_id": "Q2IBD6" }, { "db_name": "UniProt", "db_id": "Q2IBF3" }, { "db_name": "UniProt", "db_id": "Q2IBG9" }, { "db_name": "UniProt", "db_id": "Q2QL80" }, { "db_name": "UniProt", "db_id": "Q2QL91" }, { "db_name": "UniProt", "db_id": "Q2QLB1" }, { "db_name": "UniProt", "db_id": "Q2QLC2" }, { "db_name": "UniProt", "db_id": "Q2QLD3" }, { "db_name": "UniProt", "db_id": "Q2QLE2" }, { "db_name": "UniProt", "db_id": "Q2QLF3" }, { "db_name": "UniProt", "db_id": "Q2QLG7" }, { "db_name": "UniProt", "db_id": "Q2QLH8" }, { "db_name": "UniProt", "db_id": "Q66WT7" }, { "db_name": "UniProt", "db_id": "Q9WVC3" }, { "db_name": "UniProt", "db_id": "Q9YGM9" } ] }, { "id": "DS.d749.s1.e0", "type": "protein", "text": [ "caveolin-1" ], "offsets": [ [ 242, 252 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33724" }, { "db_name": "UniProt", "db_id": "P35431" }, { "db_name": "UniProt", "db_id": "P41350" }, { "db_name": "UniProt", "db_id": "P49817" }, { "db_name": "UniProt", "db_id": "P79132" }, { "db_name": "UniProt", "db_id": "Q03135" }, { "db_name": "UniProt", "db_id": "Q07DV9" }, { "db_name": "UniProt", "db_id": "Q07DX1" }, { "db_name": "UniProt", "db_id": "Q07DY2" }, { "db_name": "UniProt", "db_id": "Q07DZ2" }, { "db_name": "UniProt", "db_id": "Q07E02" }, { "db_name": "UniProt", "db_id": "Q07E25" }, { "db_name": "UniProt", "db_id": "Q07E38" }, { "db_name": "UniProt", "db_id": "Q07E49" }, { "db_name": "UniProt", "db_id": "Q09YH8" }, { "db_name": "UniProt", "db_id": "Q09YK1" }, { "db_name": "UniProt", "db_id": "Q09YN6" }, { "db_name": "UniProt", "db_id": "Q108U7" }, { "db_name": "UniProt", "db_id": "Q2IBA5" }, { "db_name": "UniProt", "db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d749.s1.e1", "type": "compound", "text": [ "ICI 182,780" ], "offsets": [ [ 282, 293 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104741" } ] }, { "id": "DS.d749.s1.e2", "type": "compound", "text": [ "pyrazolopyrimidine" ], "offsets": [ [ 297, 315 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15077741" }, { "db_name": "PubChem", "db_id": "21083976" } ] }, { "id": "DS.d749.s2.e0", "type": "compound", "text": [ "LY 294002" ], "offsets": [ [ 350, 359 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3973" } ] }, { "id": "DS.d749.s2.e1", "type": "compound", "text": [ "PD 98059" ], "offsets": [ [ 382, 390 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d749.s2.e2", "type": "protein", "text": [ "caveolin-1" ], "offsets": [ [ 448, 458 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33724" }, { "db_name": "UniProt", "db_id": "P35431" }, { "db_name": "UniProt", "db_id": "P41350" }, { "db_name": "UniProt", "db_id": "P49817" }, { "db_name": "UniProt", "db_id": "P79132" }, { "db_name": "UniProt", "db_id": "Q03135" }, { "db_name": "UniProt", "db_id": "Q07DV9" }, { "db_name": "UniProt", "db_id": "Q07DX1" }, { "db_name": "UniProt", "db_id": "Q07DY2" }, { "db_name": "UniProt", "db_id": "Q07DZ2" }, { "db_name": "UniProt", "db_id": "Q07E02" }, { "db_name": "UniProt", "db_id": "Q07E25" }, { "db_name": "UniProt", "db_id": "Q07E38" }, { "db_name": "UniProt", "db_id": "Q07E49" }, { "db_name": "UniProt", "db_id": "Q09YH8" }, { "db_name": "UniProt", "db_id": "Q09YK1" }, { "db_name": "UniProt", "db_id": "Q09YN6" }, { "db_name": "UniProt", "db_id": "Q108U7" }, { "db_name": "UniProt", "db_id": "Q2IBA5" }, { "db_name": "UniProt", "db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] }, { "id": "DS.d749.s2.e3", "type": "compound", "text": [ "thymidine" ], "offsets": [ [ 498, 507 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5789" } ] }, { "id": "DS.d749.s3.e0", "type": "protein", "text": [ "cell cycle regulatory proteins" ], "offsets": [ [ 669, 699 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18754" }, { "db_name": "UniProt", "db_id": "Q18211" } ] }, { "id": "DS.d749.s3.e1", "type": "compound", "text": [ "thymidine" ], "offsets": [ [ 708, 717 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5789" } ] } ]
[]
[]
[ { "id": "DS.d749.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s0.e2", "arg2_id": "DS.d749.s0.e0", "normalized": [] }, { "id": "DS.d749.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s0.e2", "arg2_id": "DS.d749.s0.e1", "normalized": [] }, { "id": "DS.d749.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s1.e1", "arg2_id": "DS.d749.s1.e0", "normalized": [] }, { "id": "DS.d749.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s1.e2", "arg2_id": "DS.d749.s1.e0", "normalized": [] }, { "id": "DS.d749.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s2.e3", "arg2_id": "DS.d749.s2.e2", "normalized": [] }, { "id": "DS.d749.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s2.e1", "arg2_id": "DS.d749.s2.e2", "normalized": [] }, { "id": "DS.d749.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d749.s2.e0", "arg2_id": "DS.d749.s2.e2", "normalized": [] } ]
DS.d750
18694847
[ { "id": "DS.d750.s0", "type": "", "text": [ "Almost all Akt kinase that translocates to the nucleus shows a marked phosphorylation on serine 473." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "DS.d750.s0.e0", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 11, 14 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d750.s0.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 89, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] } ]
[]
[]
[ { "id": "DS.d750.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d750.s0.e1", "arg2_id": "DS.d750.s0.e0", "normalized": [] } ]
DS.d751
18695846
[ { "id": "DS.d751.s0", "type": "", "text": [ "During the early response in AR, histamine has been found to be the most abundant mediator and it is associated with many symptoms of this disease mediated through the histamine H1 receptor." ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "DS.d751.s0.e0", "type": "compound", "text": [ "histamine" ], "offsets": [ [ 33, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "774" } ] }, { "id": "DS.d751.s0.e1", "type": "protein", "text": [ "histamine H1 receptor" ], "offsets": [ [ 168, 189 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P30546" }, { "db_name": "UniProt", "db_id": "P31389" }, { "db_name": "UniProt", "db_id": "P31390" }, { "db_name": "UniProt", "db_id": "P35367" }, { "db_name": "UniProt", "db_id": "P70174" }, { "db_name": "UniProt", "db_id": "Q9N2B0" }, { "db_name": "UniProt", "db_id": "Q9N2B1" }, { "db_name": "UniProt", "db_id": "Q9N2B2" } ] } ]
[]
[]
[ { "id": "DS.d751.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d751.s0.e0", "arg2_id": "DS.d751.s0.e1", "normalized": [] } ]
DS.d752
18695937
[ { "id": "DS.d752.s0", "type": "", "text": [ "During the incubation of L-phenylalanine with para-hydroquinones using laccase as biocatalyst, one or two main products were formed." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d752.s0.e0", "type": "compound", "text": [ "L-phenylalanine" ], "offsets": [ [ 25, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6140" } ] }, { "id": "DS.d752.s0.e1", "type": "protein", "text": [ "laccase" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12570" } ] } ]
[]
[]
[ { "id": "DS.d752.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d752.s0.e0", "arg2_id": "DS.d752.s0.e1", "normalized": [] } ]
DS.d753
18696104
[ { "id": "DS.d753.s0", "type": "", "text": [ "The effect on activation voltage but not that on amplitude was absent when expressing a cAMP-insensitive mutant (HCN2R/E), while a C-terminal truncated form of HCN2 (HCN2DeltaCx) exhibited only the voltage dependent but not the amplitude effect of erbstatin." ], "offsets": [ [ 0, 258 ] ] }, { "id": "DS.d753.s1", "type": "", "text": [ "Thus, the action of erbstatin on the activation relation and current amplitude are distinct and separable in newborn myocytes, and the effect on activation voltage depends on the cAMP status of HCN2 channels." ], "offsets": [ [ 259, 467 ] ] }, { "id": "DS.d753.s2", "type": "", "text": [ "In contrast to newborn myocytes, erbstatin had no effect on HCN2 under control conditions in adult myocytes but induced a negative shift with no change in amplitude when saturated cAMP was added to the pipette solution." ], "offsets": [ [ 468, 687 ] ] } ]
[ { "id": "DS.d753.s0.e0", "type": "protein", "text": [ "HCN2" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UL51" } ] }, { "id": "DS.d753.s0.e1", "type": "compound", "text": [ "erbstatin" ], "offsets": [ [ 248, 257 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5328552" } ] }, { "id": "DS.d753.s1.e0", "type": "compound", "text": [ "erbstatin" ], "offsets": [ [ 279, 288 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5328552" } ] }, { "id": "DS.d753.s1.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 438, 442 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d753.s1.e2", "type": "protein", "text": [ "HCN2" ], "offsets": [ [ 453, 457 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UL51" } ] }, { "id": "DS.d753.s2.e0", "type": "compound", "text": [ "erbstatin" ], "offsets": [ [ 501, 510 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5328552" } ] }, { "id": "DS.d753.s2.e1", "type": "protein", "text": [ "HCN2" ], "offsets": [ [ 528, 532 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UL51" } ] }, { "id": "DS.d753.s2.e2", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 648, 652 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] } ]
[]
[]
[ { "id": "DS.d753.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d753.s0.e1", "arg2_id": "DS.d753.s0.e0", "normalized": [] }, { "id": "DS.d753.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d753.s1.e1", "arg2_id": "DS.d753.s1.e2", "normalized": [] }, { "id": "DS.d753.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d753.s1.e0", "arg2_id": "DS.d753.s1.e2", "normalized": [] } ]
DS.d754
18696216
[ { "id": "DS.d754.s0", "type": "", "text": [ "Arginine-specific ADP-ribosyltransferase (Art) catalyzes the mono-ADP-ribosylation, in which it transfers a single ADP-ribose moiety of NAD to the arginine residue(s) of target proteins, and may regulate the function of the proteins or peptides in cellular processes." ], "offsets": [ [ 0, 267 ] ] } ]
[ { "id": "DS.d754.s0.e0", "type": "compound", "text": [ "Arginine" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d754.s0.e1", "type": "protein", "text": [ "ADP-ribosyltransferase" ], "offsets": [ [ 18, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14299" } ] }, { "id": "DS.d754.s0.e2", "type": "compound", "text": [ "NAD" ], "offsets": [ [ 136, 139 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5893" } ] }, { "id": "DS.d754.s0.e3", "type": "compound", "text": [ "arginine" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] } ]
[]
[]
[ { "id": "DS.d754.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d754.s0.e3", "arg2_id": "DS.d754.s0.e1", "normalized": [] }, { "id": "DS.d754.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d754.s0.e0", "arg2_id": "DS.d754.s0.e1", "normalized": [] }, { "id": "DS.d754.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d754.s0.e2", "arg2_id": "DS.d754.s0.e1", "normalized": [] } ]
DS.d756
18696261
[ { "id": "DS.d756.s0", "type": "", "text": [ "A D-amino acid oxidase gene (dao) was ligated with the P(Hase) and cloned into pGEMKT to constitutively express protein of DAAO without the use of any inducer such as isopropyl beta-D-1-thiogalactopyranoside which is poisonous to the cells and environment." ], "offsets": [ [ 0, 256 ] ] } ]
[ { "id": "DS.d756.s0.e0", "type": "protein", "text": [ "dao" ], "offsets": [ [ 29, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35078" }, { "db_name": "UniProt", "db_id": "P18894" } ] }, { "id": "DS.d756.s0.e1", "type": "protein", "text": [ "DAAO" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01739" }, { "db_name": "UniProt", "db_id": "O35078" }, { "db_name": "UniProt", "db_id": "P00371" }, { "db_name": "UniProt", "db_id": "P14920" }, { "db_name": "UniProt", "db_id": "P18894" }, { "db_name": "UniProt", "db_id": "P22942" }, { "db_name": "UniProt", "db_id": "P24552" }, { "db_name": "UniProt", "db_id": "P80324" }, { "db_name": "UniProt", "db_id": "Q19564" }, { "db_name": "UniProt", "db_id": "Q99042" }, { "db_name": "UniProt", "db_id": "Q9Z1M5" }, { "db_name": "UniProt", "db_id": "Q9Z302" } ] }, { "id": "DS.d756.s0.e2", "type": "compound", "text": [ "isopropyl beta-D-1-thiogalactopyranoside" ], "offsets": [ [ 167, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "656894" } ] } ]
[]
[]
[ { "id": "DS.d756.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d756.s0.e2", "arg2_id": "DS.d756.s0.e1", "normalized": [] }, { "id": "DS.d756.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d756.s0.e2", "arg2_id": "DS.d756.s0.e0", "normalized": [] } ]
DS.d757
18698091
[ { "id": "DS.d757.s0", "type": "", "text": [ "In response to a cholesterol-containing atherogenic diet, C57BL/6J mice significantly increased expression of UCP2 in the aorta, while mice lacking UCP2, in the absence of any other genetic modification, displayed significant endothelial dysfunction following the atherogenic diet." ], "offsets": [ [ 0, 281 ] ] }, { "id": "DS.d757.s1", "type": "", "text": [ "These data establish that in the vasculature UCP2 functions as an adaptive antioxidant defense to protect against the development of atherosclerosis in response to a fat and cholesterol diet." ], "offsets": [ [ 282, 473 ] ] } ]
[ { "id": "DS.d757.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 17, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d757.s0.e1", "type": "protein", "text": [ "UCP2" ], "offsets": [ [ 110, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97562" }, { "db_name": "UniProt", "db_id": "P55851" }, { "db_name": "UniProt", "db_id": "Q9N2J1" }, { "db_name": "UniProt", "db_id": "Q9W725" } ] }, { "id": "DS.d757.s0.e2", "type": "protein", "text": [ "UCP2" ], "offsets": [ [ 148, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97562" }, { "db_name": "UniProt", "db_id": "P55851" }, { "db_name": "UniProt", "db_id": "Q9N2J1" }, { "db_name": "UniProt", "db_id": "Q9W725" } ] }, { "id": "DS.d757.s1.e0", "type": "protein", "text": [ "UCP2" ], "offsets": [ [ 327, 331 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97562" }, { "db_name": "UniProt", "db_id": "P55851" }, { "db_name": "UniProt", "db_id": "Q9N2J1" }, { "db_name": "UniProt", "db_id": "Q9W725" } ] }, { "id": "DS.d757.s1.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 456, 467 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d757.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d757.s0.e0", "arg2_id": "DS.d757.s0.e1", "normalized": [] }, { "id": "DS.d757.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d757.s1.e1", "arg2_id": "DS.d757.s1.e0", "normalized": [] } ]
DS.d758
18698130
[ { "id": "DS.d758.s0", "type": "", "text": [ "To confirm that mouse DMP1-PG possesses a single GAG chain attached to Ser (89), we substituted Ser (89) by Gly (89)." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "DS.d758.s0.e0", "type": "protein", "text": [ "DMP1" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13316" }, { "db_name": "UniProt", "db_id": "Q95120" } ] }, { "id": "DS.d758.s0.e1", "type": "compound", "text": [ "Gly" ], "offsets": [ [ 108, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" }, { "db_name": "PubChem", "db_id": "5460845" } ] } ]
[]
[]
[ { "id": "DS.d758.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d758.s0.e1", "arg2_id": "DS.d758.s0.e0", "normalized": [] } ]
DS.d759
18698132
[ { "id": "DS.d759.s0", "type": "", "text": [ "PC-1 is the primary generator of pyrophosphate in osteoblastic cells; therefore, regulated expression of PC-1 by FGFs may be a principal mechanism by which FGF signaling affects bone mineralization." ], "offsets": [ [ 0, 198 ] ] } ]
[ { "id": "DS.d759.s0.e0", "type": "compound", "text": [ "pyrophosphate" ], "offsets": [ [ 33, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "644102" } ] }, { "id": "DS.d759.s0.e1", "type": "protein", "text": [ "FGFs" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O10284" }, { "db_name": "UniProt", "db_id": "P41444" } ] }, { "id": "DS.d759.s0.e2", "type": "protein", "text": [ "FGF" ], "offsets": [ [ 113, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O10284" }, { "db_name": "UniProt", "db_id": "P41444" } ] } ]
[]
[]
[ { "id": "DS.d759.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d759.s0.e0", "arg2_id": "DS.d759.s0.e2", "normalized": [] }, { "id": "DS.d759.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d759.s0.e0", "arg2_id": "DS.d759.s0.e1", "normalized": [] } ]
DS.d760
18698333
[ { "id": "DS.d760.s0", "type": "", "text": [ "In analogy to the reduction of Ca(2+) oscillation frequency, the blockers impaired HCEC contraction, NF-kappaB activation, and VCAM-1 expression." ], "offsets": [ [ 0, 145 ] ] }, { "id": "DS.d760.s1", "type": "", "text": [ "Cisternal SAH-CSF induces cytosolic Ca(2+) oscillations in HCEC that results in cellular constriction, NF-kappaB activation, and VCAM-1 expression." ], "offsets": [ [ 146, 293 ] ] } ]
[ { "id": "DS.d760.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d760.s0.e1", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 127, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] }, { "id": "DS.d760.s1.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 182, 186 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d760.s1.e1", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 275, 281 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] } ]
[]
[]
[ { "id": "DS.d760.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d760.s0.e0", "arg2_id": "DS.d760.s0.e1", "normalized": [] }, { "id": "DS.d760.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d760.s1.e0", "arg2_id": "DS.d760.s1.e1", "normalized": [] } ]
DS.d761
18698636
[ { "id": "DS.d761.s0", "type": "", "text": [ "For proof of principle, we use L-lactate and D-lactate as representative pair of enantiomers, L-lactate oxidase as stereospecific signal generator, and cascade blue hydrazide as reactive signal amplifier to capture the produced pyruvate." ], "offsets": [ [ 0, 237 ] ] } ]
[ { "id": "DS.d761.s0.e0", "type": "compound", "text": [ "L-lactate" ], "offsets": [ [ 31, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107689" } ] }, { "id": "DS.d761.s0.e1", "type": "compound", "text": [ "D-lactate" ], "offsets": [ [ 45, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "61503" } ] }, { "id": "DS.d761.s0.e2", "type": "protein", "text": [ "lactate oxidase" ], "offsets": [ [ 96, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21795" } ] }, { "id": "DS.d761.s0.e3", "type": "compound", "text": [ "pyruvate" ], "offsets": [ [ 228, 236 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1060" } ] } ]
[]
[]
[]
DS.d762
18698648
[ { "id": "DS.d762.s0", "type": "", "text": [ "Escherichia coli strain PC09 (DeltaxylB, cAMP-independent CRP (crp *) mutant) expressing an NADPH-dependent xylose reductase from Candida boidinii (CbXR) was previously reported to produce xylitol from xylose while metabolizing glucose (Cirino et al." ], "offsets": [ [ 0, 250 ] ] }, { "id": "DS.d762.s1", "type": "", "text": [ "Studies in which the expression of CbXR or a xylose transporter was increased suggest that enzyme activity and xylose transport are not limiting xylitol production in PC09." ], "offsets": [ [ 251, 423 ] ] }, { "id": "DS.d762.s2", "type": "", "text": [ "For the case of xylose-proton symport, omitting the Zwf (glucose-6-phosphate dehydrogenase) or PntAB (membrane-bound transhydrogenase) reactions or TCA cycle activity from the model reduces the theoretical maximum yield from 9.2 to 8.8, 3.6, and 8.0 mol xylitol (mol glucose)(-1), respectively." ], "offsets": [ [ 424, 718 ] ] }, { "id": "DS.d762.s3", "type": "", "text": [ "Experimentally, deleting pgi (encoding phosphoglucose isomerase) from strain PC09 improves the yield from 3.4 to 4.0 mol xylitol (mol glucose)(-1), while deleting either or both E. coli transhydrogenases (sthA and pntA) has no significant effect on the measured yield." ], "offsets": [ [ 719, 987 ] ] }, { "id": "DS.d762.s4", "type": "", "text": [ "Deleting either zwf or sucC (TCA cycle) significantly reduces the yield from 3.4 to 2.0 and 2.3 mol xylitol (mol glucose)(-1), respectively." ], "offsets": [ [ 988, 1128 ] ] } ]
[ { "id": "DS.d762.s0.e0", "type": "protein", "text": [ "xylose reductase" ], "offsets": [ [ 108, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P38715" } ] }, { "id": "DS.d762.s0.e1", "type": "compound", "text": [ "xylitol" ], "offsets": [ [ 189, 196 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6912" } ] }, { "id": "DS.d762.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 228, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d762.s1.e0", "type": "protein", "text": [ "xylose transporter" ], "offsets": [ [ 296, 314 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P96792" } ] }, { "id": "DS.d762.s1.e1", "type": "compound", "text": [ "xylitol" ], "offsets": [ [ 396, 403 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6912" } ] }, { "id": "DS.d762.s2.e0", "type": "protein", "text": [ "Zwf" ], "offsets": [ [ 476, 479 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O51581" }, { "db_name": "UniProt", "db_id": "O54537" }, { "db_name": "UniProt", "db_id": "O68282" }, { "db_name": "UniProt", "db_id": "O83491" }, { "db_name": "UniProt", "db_id": "O84188" }, { "db_name": "UniProt", "db_id": "P0A584" }, { "db_name": "UniProt", "db_id": "P0A585" }, { "db_name": "UniProt", "db_id": "P0A586" }, { "db_name": "UniProt", "db_id": "P0A587" }, { "db_name": "UniProt", "db_id": "P0AC53" }, { "db_name": "UniProt", "db_id": "P0AC54" }, { "db_name": "UniProt", "db_id": "P11411" }, { "db_name": "UniProt", "db_id": "P21907" }, { "db_name": "UniProt", "db_id": "P29686" }, { "db_name": "UniProt", "db_id": "P37986" }, { "db_name": "UniProt", "db_id": "P44311" }, { "db_name": "UniProt", "db_id": "P48848" }, { "db_name": "UniProt", "db_id": "P48992" }, { "db_name": "UniProt", "db_id": "P54547" }, { "db_name": "UniProt", "db_id": "P56110" }, { "db_name": "UniProt", "db_id": "P57405" }, { "db_name": "UniProt", "db_id": "P73411" }, { "db_name": "UniProt", "db_id": "P77809" }, { "db_name": "UniProt", "db_id": "Q89AI7" }, { "db_name": "UniProt", "db_id": "Q8K9M2" }, { "db_name": "UniProt", "db_id": "Q8XCJ6" }, { "db_name": "UniProt", "db_id": "Q9PKK8" }, { "db_name": "UniProt", "db_id": "Q9X0N9" }, { "db_name": "UniProt", "db_id": "Q9Z3S2" }, { "db_name": "UniProt", "db_id": "Q9Z8U6" }, { "db_name": "UniProt", "db_id": "Q9ZKB2" } ] }, { "id": "DS.d762.s2.e1", "type": "protein", "text": [ "PntAB" ], "offsets": [ [ 519, 524 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C187" }, { "db_name": "UniProt", "db_id": "P51995" }, { "db_name": "UniProt", "db_id": "Q2RSB3" } ] }, { "id": "DS.d762.s2.e2", "type": "compound", "text": [ "xylitol" ], "offsets": [ [ 678, 685 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6912" } ] }, { "id": "DS.d762.s3.e0", "type": "protein", "text": [ "pgi" ], "offsets": [ [ 744, 747 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O25781" }, { "db_name": "UniProt", "db_id": "O51672" }, { "db_name": "UniProt", "db_id": "O83488" }, { "db_name": "UniProt", "db_id": "O84382" }, { "db_name": "UniProt", "db_id": "O88015" }, { "db_name": "UniProt", "db_id": "P0A0T0" }, { "db_name": "UniProt", "db_id": "P0A0T1" }, { "db_name": "UniProt", "db_id": "P0A6T1" }, { "db_name": "UniProt", "db_id": "P0A6T2" }, { "db_name": "UniProt", "db_id": "P28718" }, { "db_name": "UniProt", "db_id": "P44312" }, { "db_name": "UniProt", "db_id": "P47357" }, { "db_name": "UniProt", "db_id": "P52029" }, { "db_name": "UniProt", "db_id": "P52030" }, { "db_name": "UniProt", "db_id": "P52031" }, { "db_name": "UniProt", "db_id": "P52983" }, { "db_name": "UniProt", "db_id": "P57636" }, { "db_name": "UniProt", "db_id": "P64192" }, { "db_name": "UniProt", "db_id": "P64193" }, { "db_name": "UniProt", "db_id": "P64194" }, { "db_name": "UniProt", "db_id": "P64195" }, { "db_name": "UniProt", "db_id": "P64196" }, { "db_name": "UniProt", "db_id": "P77877" }, { "db_name": "UniProt", "db_id": "P78033" }, { "db_name": "UniProt", "db_id": "P80860" }, { "db_name": "UniProt", "db_id": "P81181" }, { "db_name": "UniProt", "db_id": "P96803" }, { "db_name": "UniProt", "db_id": "P99078" }, { "db_name": "UniProt", "db_id": "Q0TA36" }, { "db_name": "UniProt", "db_id": "Q0VR14" }, { "db_name": "UniProt", "db_id": "Q11MA0" }, { "db_name": "UniProt", "db_id": "Q13Z07" }, { "db_name": "UniProt", "db_id": "Q165T7" }, { "db_name": "UniProt", "db_id": "Q18FQ4" }, { "db_name": "UniProt", "db_id": "Q1ASN4" }, { "db_name": "UniProt", "db_id": "Q1BH79" }, { "db_name": "UniProt", "db_id": "Q1CSA0" }, { "db_name": "UniProt", "db_id": "Q1CX51" }, { "db_name": "UniProt", "db_id": "Q1GAY0" }, { "db_name": "UniProt", "db_id": "Q1GJQ5" }, { "db_name": "UniProt", "db_id": "Q1GTU1" }, { "db_name": "UniProt", "db_id": "Q1H1P4" }, { "db_name": "UniProt", "db_id": "Q1IYT4" }, { "db_name": "UniProt", "db_id": "Q1J8N2" }, { "db_name": "UniProt", "db_id": 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"db_name": "UniProt", "db_id": "Q98EC5" }, { "db_name": "UniProt", "db_id": "Q9AB94" }, { "db_name": "UniProt", "db_id": "Q9CNZ0" }, { "db_name": "UniProt", "db_id": "Q9EYG9" }, { "db_name": "UniProt", "db_id": "Q9HPP1" }, { "db_name": "UniProt", "db_id": "Q9JUT0" }, { "db_name": "UniProt", "db_id": "Q9JZP4" }, { "db_name": "UniProt", "db_id": "Q9KA20" }, { "db_name": "UniProt", "db_id": "Q9KQB5" }, { "db_name": "UniProt", "db_id": "Q9PAH1" }, { "db_name": "UniProt", "db_id": "Q9PHY1" }, { "db_name": "UniProt", "db_id": "Q9PL99" }, { "db_name": "UniProt", "db_id": "Q9RUY3" }, { "db_name": "UniProt", "db_id": "Q9Z5H8" }, { "db_name": "UniProt", "db_id": "Q9Z6T6" } ] }, { "id": "DS.d762.s4.e2", "type": "compound", "text": [ "xylitol" ], "offsets": [ [ 1088, 1095 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6912" } ] }, { "id": "DS.d762.s4.e3", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 1101, 1108 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
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DS.d763
18698649
[ { "id": "DS.d763.s0", "type": "", "text": [ "In the process studied, the enzyme cellobiose dehydrogenase (CDH) oxidizes lactose at the C-1 position of the reducing sugar moiety to lactobionolactone, which spontaneously hydrolyzes to lactobionic acid." ], "offsets": [ [ 0, 205 ] ] }, { "id": "DS.d763.s2", "type": "", "text": [ "Oxygen served as the terminal electron acceptor of the reaction and was fully reduced to water by laccase." ], "offsets": [ [ 206, 312 ] ] } ]
[ { "id": "DS.d763.s0.e0", "type": "protein", "text": [ "CDH" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17444" }, { "db_name": "UniProt", "db_id": "P54223" }, { "db_name": "UniProt", "db_id": "P60336" }, { "db_name": "UniProt", "db_id": "P60337" }, { "db_name": "UniProt", "db_id": "Q01738" }, { "db_name": "UniProt", "db_id": "Q0TKW1" }, { "db_name": "UniProt", "db_id": "Q13NG7" }, { "db_name": "UniProt", "db_id": "Q1BQE2" }, { "db_name": "UniProt", "db_id": "Q1C932" }, { "db_name": "UniProt", "db_id": "Q1CFR7" }, { "db_name": "UniProt", "db_id": "Q1MJU4" }, { "db_name": "UniProt", "db_id": "Q1QXE1" }, { "db_name": "UniProt", "db_id": "Q1RFM3" }, { "db_name": "UniProt", "db_id": "Q2FDP9" }, { "db_name": "UniProt", "db_id": "Q2FV11" }, { "db_name": "UniProt", "db_id": "Q2KB43" }, { "db_name": "UniProt", "db_id": "Q2T6D0" }, { "db_name": "UniProt", "db_id": "Q2YWJ5" }, { "db_name": "UniProt", "db_id": "Q39A44" }, { "db_name": "UniProt", "db_id": "Q3BXK8" }, { "db_name": "UniProt", "db_id": "Q3JLL7" }, { "db_name": "UniProt", "db_id": "Q3K5H3" }, { "db_name": "UniProt", "db_id": "Q48CM7" }, { "db_name": "UniProt", "db_id": "Q4A0Q1" }, { "db_name": "UniProt", "db_id": "Q4K4K7" }, { "db_name": "UniProt", "db_id": "Q4L9D7" }, { "db_name": "UniProt", "db_id": "Q4UYN5" }, { "db_name": "UniProt", "db_id": "Q4ZM63" }, { "db_name": "UniProt", "db_id": "Q5HCU1" }, { "db_name": "UniProt", "db_id": "Q5HL11" }, { "db_name": "UniProt", "db_id": "Q62CH8" }, { "db_name": "UniProt", "db_id": "Q63KK7" }, { "db_name": "UniProt", "db_id": "Q66D54" }, { "db_name": "UniProt", "db_id": "Q6D6D9" }, { "db_name": "UniProt", "db_id": "Q6FDF9" }, { "db_name": "UniProt", "db_id": "Q6G664" }, { "db_name": "UniProt", "db_id": "Q6GDJ1" }, { "db_name": "UniProt", "db_id": "Q6LGH5" }, { "db_name": "UniProt", "db_id": "Q7MF12" }, { "db_name": "UniProt", "db_id": "Q88AE7" }, { "db_name": "UniProt", "db_id": "Q88CW6" }, { "db_name": "UniProt", "db_id": "Q8BJ64" }, { "db_name": "UniProt", "db_id": "Q8CMY2" }, { "db_name": "UniProt", "db_id": "Q8D3K2" }, { "db_name": "UniProt", "db_id": "Q8FKI9" }, { "db_name": "UniProt", "db_id": "Q8G1Z8" }, { "db_name": "UniProt", "db_id": "Q8NE62" }, { "db_name": "UniProt", "db_id": "Q8NUM0" }, { "db_name": "UniProt", "db_id": "Q8P5D7" }, { "db_name": "UniProt", "db_id": "Q8PPG8" }, { "db_name": "UniProt", "db_id": "Q8UH55" }, { "db_name": "UniProt", "db_id": "Q8X6C6" }, { "db_name": "UniProt", "db_id": "Q8YFY2" }, { "db_name": "UniProt", "db_id": "Q8ZGW0" }, { "db_name": "UniProt", "db_id": "Q985M5" }, { "db_name": "UniProt", "db_id": "Q9HTJ2" }, { "db_name": "UniProt", "db_id": "Q9L4K0" }, { "db_name": "UniProt", "db_id": "Q9RA05" }, { "db_name": "UniProt", "db_id": "Q9X2M2" } ] }, { "id": "DS.d763.s0.e1", "type": "compound", "text": [ "lactose" ], "offsets": [ [ 75, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "294" }, { "db_name": "PubChem", "db_id": "6134" }, { "db_name": "PubChem", "db_id": "84571" }, { "db_name": "PubChem", "db_id": "440995" } ] }, { "id": "DS.d763.s0.e2", "type": "compound", "text": [ "lactobionic acid" ], "offsets": [ [ 188, 204 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7314" } ] }, { "id": "DS.d763.s2.e0", "type": "compound", "text": [ "Oxygen" ], "offsets": [ [ 206, 212 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d763.s2.e1", "type": "protein", "text": [ "laccase" ], "offsets": [ [ 304, 311 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12570" } ] } ]
[]
[]
[ { "id": "DS.d763.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d763.s0.e2", "arg2_id": "DS.d763.s0.e0", "normalized": [] }, { "id": "DS.d763.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d763.s0.e1", "arg2_id": "DS.d763.s0.e0", "normalized": [] }, { "id": "DS.d763.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d763.s2.e0", "arg2_id": "DS.d763.s2.e1", "normalized": [] } ]
DS.d764
18699724
[ { "id": "DS.d764.s0", "type": "", "text": [ "Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz." ], "offsets": [ [ 0, 239 ] ] } ]
[ { "id": "DS.d764.s0.e0", "type": "compound", "text": [ "SSEA-3" ], "offsets": [ [ 61, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "53262342" } ] }, { "id": "DS.d764.s0.e1", "type": "compound", "text": [ "TRA" ], "offsets": [ [ 77, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444212" } ] }, { "id": "DS.d764.s0.e2", "type": "compound", "text": [ "TRA" ], "offsets": [ [ 91, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444212" } ] }, { "id": "DS.d764.s0.e3", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 114, 134 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d764.s0.e4", "type": "protein", "text": [ "reverse transcriptase" ], "offsets": [ [ 139, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03358" }, { "db_name": "UniProt", "db_id": "P03554" }, { "db_name": "UniProt", "db_id": "P03555" }, { "db_name": "UniProt", "db_id": "P03556" }, { "db_name": "UniProt", "db_id": "P04323" }, { "db_name": "UniProt", "db_id": "P05400" }, { "db_name": "UniProt", "db_id": "P09523" }, { "db_name": "UniProt", "db_id": "P0A3U0" }, { "db_name": "UniProt", "db_id": "P0A3U1" }, { "db_name": "UniProt", "db_id": "P10394" }, { "db_name": "UniProt", "db_id": "P10399" }, { "db_name": "UniProt", "db_id": "P10400" }, { "db_name": "UniProt", "db_id": "P10401" }, { "db_name": "UniProt", "db_id": "P10978" }, { "db_name": "UniProt", "db_id": "P11283" }, { "db_name": "UniProt", "db_id": "P11369" }, { "db_name": "UniProt", "db_id": "P15629" }, { "db_name": "UniProt", "db_id": "P16423" }, { "db_name": "UniProt", "db_id": "P19199" }, { "db_name": "UniProt", "db_id": "P20825" }, { "db_name": "UniProt", "db_id": "P21325" }, { "db_name": "UniProt", "db_id": "P21328" }, { "db_name": "UniProt", "db_id": "P21329" }, { "db_name": "UniProt", "db_id": "P23070" }, { "db_name": "UniProt", "db_id": "P23071" }, { "db_name": "UniProt", "db_id": "P23072" }, { "db_name": "UniProt", "db_id": "P27502" }, { "db_name": "UniProt", "db_id": "Q00962" }, { "db_name": "UniProt", "db_id": "Q02964" }, { "db_name": "UniProt", "db_id": "Q03269" }, { "db_name": "UniProt", "db_id": "Q03270" }, { "db_name": "UniProt", "db_id": "Q03271" }, { "db_name": "UniProt", "db_id": "Q03272" }, { "db_name": "UniProt", "db_id": "Q03273" }, { "db_name": "UniProt", "db_id": "Q03274" }, { "db_name": "UniProt", "db_id": "Q03275" }, { "db_name": "UniProt", "db_id": "Q03276" }, { "db_name": "UniProt", "db_id": "Q03277" }, { "db_name": "UniProt", "db_id": "Q03278" }, { "db_name": "UniProt", "db_id": "Q03279" }, { "db_name": "UniProt", "db_id": "Q05118" }, { "db_name": "UniProt", "db_id": "Q8I7P9" }, { "db_name": "UniProt", "db_id": "Q95SX7" }, { "db_name": "UniProt", "db_id": "Q9NBX4" }, { "db_name": "UniProt", "db_id": "Q9QC07" } ] }, { "id": "DS.d764.s0.e5", "type": "protein", "text": [ "PCR" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O66148" }, { "db_name": "UniProt", "db_id": "O80333" }, { "db_name": "UniProt", "db_id": "P15904" }, { "db_name": "UniProt", "db_id": "Q01289" }, { "db_name": "UniProt", "db_id": "Q39617" }, { "db_name": "UniProt", "db_id": "Q41249" }, { "db_name": "UniProt", "db_id": "Q59987" }, { "db_name": "UniProt", "db_id": "Q9SDT1" } ] } ]
[]
[]
[]
DS.d765
18699774
[ { "id": "DS.d765.s0", "type": "", "text": [ "Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu." ], "offsets": [ [ 0, 158 ] ] }, { "id": "DS.d765.s1", "type": "", "text": [ "SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated." ], "offsets": [ [ 159, 513 ] ] } ]
[ { "id": "DS.d765.s0.e0", "type": "compound", "text": [ "Solamargine" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "73611" } ] }, { "id": "DS.d765.s0.e1", "type": "compound", "text": [ "epirubicin" ], "offsets": [ [ 77, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "41867" } ] }, { "id": "DS.d765.s0.e2", "type": "protein", "text": [ "HER2" ], "offsets": [ [ 149, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04626" } ] }, { "id": "DS.d765.s0.e3", "type": "protein", "text": [ "neu" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35657" }, { "db_name": "UniProt", "db_id": "P06494" }, { "db_name": "UniProt", "db_id": "P29503" }, { "db_name": "UniProt", "db_id": "P70424" }, { "db_name": "UniProt", "db_id": "Q24746" } ] }, { "id": "DS.d765.s1.e0", "type": "compound", "text": [ "solamargine" ], "offsets": [ [ 163, 174 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "73611" } ] }, { "id": "DS.d765.s1.e1", "type": "compound", "text": [ "steroidal alkaloid" ], "offsets": [ [ 185, 203 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "452975" } ] }, { "id": "DS.d765.s1.e2", "type": "protein", "text": [ "HER2" ], "offsets": [ [ 470, 474 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04626" } ] }, { "id": "DS.d765.s1.e3", "type": "protein", "text": [ "neu" ], "offsets": [ [ 475, 478 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35657" }, { "db_name": "UniProt", "db_id": "P06494" }, { "db_name": "UniProt", "db_id": "P29503" }, { "db_name": "UniProt", "db_id": "P70424" }, { "db_name": "UniProt", "db_id": "Q24746" } ] } ]
[]
[]
[]
DS.d766
18700056
[ { "id": "DS.d766.s0", "type": "", "text": [ "Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d766.s0.e0", "type": "compound", "text": [ "ondansetron" ], "offsets": [ [ 6, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4595" } ] }, { "id": "DS.d766.s0.e1", "type": "compound", "text": [ "clorgyline" ], "offsets": [ [ 53, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4380" } ] }, { "id": "DS.d766.s0.e2", "type": "protein", "text": [ "MAOA" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18851" }, { "db_name": "UniProt", "db_id": "P21397" }, { "db_name": "UniProt", "db_id": "P21398" }, { "db_name": "UniProt", "db_id": "P58027" }, { "db_name": "UniProt", "db_id": "Q5NU32" }, { "db_name": "UniProt", "db_id": "Q5RE60" }, { "db_name": "UniProt", "db_id": "Q6Q2J0" } ] }, { "id": "DS.d766.s0.e3", "type": "protein", "text": [ "5-HT3" ], "offsets": [ [ 147, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70212" }, { "db_name": "UniProt", "db_id": "P23979" }, { "db_name": "UniProt", "db_id": "P35563" }, { "db_name": "UniProt", "db_id": "P46098" } ] } ]
[]
[]
[]
DS.d767
18700057
[ { "id": "DS.d767.s0", "type": "", "text": [ "The effects of Ipt were reversed by the mitochondrial KATP blocker, 5-hydroxydecanoate, indicating that mitochondrial KATP channels participate in the regulation of astrocyte activation." ], "offsets": [ [ 0, 186 ] ] } ]
[ { "id": "DS.d767.s0.e0", "type": "protein", "text": [ "Ipt" ], "offsets": [ [ 15, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0A3L5" }, { "db_name": "UniProt", "db_id": "P0A3L6" }, { "db_name": "UniProt", "db_id": "P15653" }, { "db_name": "UniProt", "db_id": "P25018" }, { "db_name": "UniProt", "db_id": "P46376" }, { "db_name": "UniProt", "db_id": "Q04590" }, { "db_name": "UniProt", "db_id": "Q47851" }, { "db_name": "UniProt", "db_id": "Q80UN9" } ] }, { "id": "DS.d767.s0.e1", "type": "compound", "text": [ "5-hydroxydecanoate" ], "offsets": [ [ 68, 86 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1825" } ] } ]
[]
[]
[ { "id": "DS.d767.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d767.s0.e1", "arg2_id": "DS.d767.s0.e0", "normalized": [] } ]
DS.d768
18700809
[ { "id": "DS.d768.s0", "type": "", "text": [ "The cell proliferation, the up-regulation of pS2, and the down-regulation of ERalpha and ERbeta gene expressions induced by the racemate and enantiomers of o,p'-DDT were all reversed by cotreatment with 10(-6) mol/L ICI 182,780." ], "offsets": [ [ 0, 228 ] ] } ]
[ { "id": "DS.d768.s0.e0", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d768.s0.e1", "type": "protein", "text": [ "ERbeta" ], "offsets": [ [ 89, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08537" }, { "db_name": "UniProt", "db_id": "O13012" }, { "db_name": "UniProt", "db_id": "O93511" }, { "db_name": "UniProt", "db_id": "P57781" }, { "db_name": "UniProt", "db_id": "P57782" }, { "db_name": "UniProt", "db_id": "Q62986" }, { "db_name": "UniProt", "db_id": "Q92731" }, { "db_name": "UniProt", "db_id": "Q95171" }, { "db_name": "UniProt", "db_id": "Q9IAK1" }, { "db_name": "UniProt", "db_id": "Q9PTU5" }, { "db_name": "UniProt", "db_id": "Q9PVE2" }, { "db_name": "UniProt", "db_id": "Q9TTE5" }, { "db_name": "UniProt", "db_id": "Q9TU15" }, { "db_name": "UniProt", "db_id": "Q9W6M2" }, { "db_name": "UniProt", "db_id": "Q9XSB5" }, { "db_name": "UniProt", "db_id": "Q9XSW2" }, { "db_name": "UniProt", "db_id": "Q9YH32" } ] }, { "id": "DS.d768.s0.e2", "type": "compound", "text": [ "ICI 182,780" ], "offsets": [ [ 216, 227 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104741" } ] } ]
[]
[]
[ { "id": "DS.d768.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d768.s0.e2", "arg2_id": "DS.d768.s0.e0", "normalized": [] }, { "id": "DS.d768.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d768.s0.e2", "arg2_id": "DS.d768.s0.e1", "normalized": [] } ]
DS.d769
18700818
[ { "id": "DS.d769.s0", "type": "", "text": [ "While bass in all diazinon treatment groups had significantly inhibited brain AChE activity, only the medium and high treatment groups showed a dose- and time-dependent increase in time to capture prey." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d769.s0.e0", "type": "compound", "text": [ "diazinon" ], "offsets": [ [ 18, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3017" } ] }, { "id": "DS.d769.s0.e1", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 78, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] } ]
[]
[]
[ { "id": "DS.d769.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d769.s0.e0", "arg2_id": "DS.d769.s0.e1", "normalized": [] } ]
DS.d770
18701427
[ { "id": "DS.d770.s0", "type": "", "text": [ "The aim of this phase 0 study was to investigate whether gemcitabine passes the blood-tumor barrier, and is phosphorylated in the tumor by deoxycytidine kinase (dCK) to gemcitabine nucleotides in order to enable radiosensitization, and whether it is deaminated by deoxycytidine deaminase (dCDA) to dFdU." ], "offsets": [ [ 0, 303 ] ] } ]
[ { "id": "DS.d770.s0.e0", "type": "compound", "text": [ "gemcitabine" ], "offsets": [ [ 57, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60750" } ] }, { "id": "DS.d770.s0.e1", "type": "protein", "text": [ "deoxycytidine kinase" ], "offsets": [ [ 139, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27707" }, { "db_name": "UniProt", "db_id": "P43346" }, { "db_name": "UniProt", "db_id": "P48769" } ] }, { "id": "DS.d770.s0.e2", "type": "protein", "text": [ "dCK" ], "offsets": [ [ 161, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21974" }, { "db_name": "UniProt", "db_id": "P27707" }, { "db_name": "UniProt", "db_id": "P43346" }, { "db_name": "UniProt", "db_id": "P48769" }, { "db_name": "UniProt", "db_id": "Q9J579" } ] }, { "id": "DS.d770.s0.e3", "type": "compound", "text": [ "gemcitabine" ], "offsets": [ [ 169, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60750" } ] } ]
[]
[]
[ { "id": "DS.d770.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d770.s0.e0", "arg2_id": "DS.d770.s0.e1", "normalized": [] }, { "id": "DS.d770.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d770.s0.e0", "arg2_id": "DS.d770.s0.e2", "normalized": [] } ]
DS.d771
18701806
[ { "id": "DS.d771.s0", "type": "", "text": [ "The proline mutation at amino acid location 164 significantly reduced the initial hydrolysis of either the amelogenins in solution or the proteins bound on HAP, which was confirmed by amelogenin oligopeptide assays." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "DS.d771.s0.e0", "type": "compound", "text": [ "proline" ], "offsets": [ [ 4, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] }, { "id": "DS.d771.s0.e1", "type": "protein", "text": [ "amelogenins" ], "offsets": [ [ 107, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97646" }, { "db_name": "UniProt", "db_id": "O97647" }, { "db_name": "UniProt", "db_id": "Q28462" } ] } ]
[]
[]
[ { "id": "DS.d771.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d771.s0.e0", "arg2_id": "DS.d771.s0.e1", "normalized": [] } ]
DS.d772
18701809
[ { "id": "DS.d772.s0", "type": "", "text": [ "In conclusion, dentin mineralization in a corrected phosphate and vitamin D environment compensates the adverse effect of PHEX mutation." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "DS.d772.s0.e0", "type": "compound", "text": [ "phosphate" ], "offsets": [ [ 52, 61 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" }, { "db_name": "PubChem", "db_id": "167704" }, { "db_name": "PubChem", "db_id": "644102" } ] }, { "id": "DS.d772.s0.e1", "type": "compound", "text": [ "vitamin D" ], "offsets": [ [ 66, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280795" } ] }, { "id": "DS.d772.s0.e2", "type": "protein", "text": [ "PHEX" ], "offsets": [ [ 122, 126 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P78562" } ] } ]
[]
[]
[]
DS.d773
18702173
[ { "id": "DS.d773.s0", "type": "", "text": [ "The considered biological model system consisted of a coating antibody (goat IgG), bovine serum albumin (BSA) as blocking agent, and a complementary antibody labelled with FITC (anti-goat IgG)." ], "offsets": [ [ 0, 193 ] ] } ]
[ { "id": "DS.d773.s0.e0", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 90, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d773.s0.e1", "type": "protein", "text": [ "BSA" ], "offsets": [ [ 105, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02769" } ] }, { "id": "DS.d773.s0.e2", "type": "compound", "text": [ "FITC" ], "offsets": [ [ 172, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "18730" } ] } ]
[]
[]
[]
DS.d774
18702613
[ { "id": "DS.d774.s0", "type": "", "text": [ "Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells." ], "offsets": [ [ 0, 149 ] ] }, { "id": "DS.d774.s1", "type": "", "text": [ "Collectively, these results illustrate the phenomenon of beta-cell desensitization by amino acids, indicating that prolonged exposure to alanine can induce reversible alterations to metabolic flux, Ca(2+) handling and insulin secretion." ], "offsets": [ [ 150, 386 ] ] } ]
[ { "id": "DS.d774.s0.e0", "type": "compound", "text": [ "alanine" ], "offsets": [ [ 12, 19 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "602" }, { "db_name": "PubChem", "db_id": "4580" }, { "db_name": "PubChem", "db_id": "5950" }, { "db_name": "PubChem", "db_id": "71080" } ] }, { "id": "DS.d774.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 60, 64 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d774.s0.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d774.s1.e0", "type": "compound", "text": [ "alanine" ], "offsets": [ [ 287, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "602" }, { "db_name": "PubChem", "db_id": "4580" }, { "db_name": "PubChem", "db_id": "5950" }, { "db_name": "PubChem", "db_id": "71080" } ] }, { "id": "DS.d774.s1.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 348, 352 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d774.s1.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 368, 375 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d774.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d774.s0.e0", "arg2_id": "DS.d774.s0.e2", "normalized": [] }, { "id": "DS.d774.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d774.s1.e0", "arg2_id": "DS.d774.s1.e2", "normalized": [] } ]
DS.d775
18702682
[ { "id": "DS.d775.s0", "type": "", "text": [ "Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes." ], "offsets": [ [ 0, 134 ] ] } ]
[ { "id": "DS.d775.s0.e0", "type": "protein", "text": [ "ASP" ], "offsets": [ [ 31, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32765" }, { "db_name": "UniProt", "db_id": "P42127" }, { "db_name": "UniProt", "db_id": "P45381" }, { "db_name": "UniProt", "db_id": "P79407" }, { "db_name": "UniProt", "db_id": "Q03288" }, { "db_name": "UniProt", "db_id": "Q16937" }, { "db_name": "UniProt", "db_id": "Q1XGU5" }, { "db_name": "UniProt", "db_id": "Q1XGU6" }, { "db_name": "UniProt", "db_id": "Q1XGU7" }, { "db_name": "UniProt", "db_id": "Q1XGU8" }, { "db_name": "UniProt", "db_id": "Q1XGU9" }, { "db_name": "UniProt", "db_id": "Q1XGV0" }, { "db_name": "UniProt", "db_id": "Q1XGV1" }, { "db_name": "UniProt", "db_id": "Q1XGV2" }, { "db_name": "UniProt", "db_id": "Q1XGV3" }, { "db_name": "UniProt", "db_id": "Q1XGV4" }, { "db_name": "UniProt", "db_id": "Q1XGV5" }, { "db_name": "UniProt", "db_id": "Q1XGV6" }, { "db_name": "UniProt", "db_id": "Q1XGV7" }, { "db_name": "UniProt", "db_id": "Q29414" }, { "db_name": "UniProt", "db_id": "Q5UK76" }, { "db_name": "UniProt", "db_id": "Q6ZYM3" }, { "db_name": "UniProt", "db_id": "Q865F0" }, { "db_name": "UniProt", "db_id": "Q95MP2" }, { "db_name": "UniProt", "db_id": "Q99JA2" }, { "db_name": "UniProt", "db_id": "Q9H1Y0" }, { "db_name": "UniProt", "db_id": "Q9NQ94" } ] }, { "id": "DS.d775.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 105, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d775.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d775.s0.e1", "arg2_id": "DS.d775.s0.e0", "normalized": [] } ]
DS.d776
18703100
[ { "id": "DS.d776.s0", "type": "", "text": [ "Using a set of experiments aimed at manipulate a putative l-glutamate/NMDA/NO signal transduction pathway, we have demonstrated, by quantitative real-time PCR, that NMDA enhances the expression of GnRH mRNA in a dose-response manner." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "DS.d776.s0.e0", "type": "compound", "text": [ "l-glutamate" ], "offsets": [ [ 58, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "33032" } ] }, { "id": "DS.d776.s0.e1", "type": "compound", "text": [ "NMDA" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "22880" } ] }, { "id": "DS.d776.s0.e2", "type": "compound", "text": [ "NMDA" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "22880" } ] }, { "id": "DS.d776.s0.e3", "type": "protein", "text": [ "GnRH" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27429" } ] } ]
[]
[]
[ { "id": "DS.d776.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d776.s0.e0", "arg2_id": "DS.d776.s0.e3", "normalized": [] }, { "id": "DS.d776.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d776.s0.e1", "arg2_id": "DS.d776.s0.e3", "normalized": [] } ]
DS.d777
18703333
[ { "id": "DS.d777.s0", "type": "", "text": [ "Reaction parameters for the production of XOS from corncob using endoxylanase from Aspergillus oryzae MTCC 5154 were optimized and an XOS yield of 10.2+/-0.14 mg ml(-1) corresponding to 81+/-3.9% with 73.5% xylobiose was obtained." ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "DS.d777.s0.e0", "type": "protein", "text": [ "endoxylanase" ], "offsets": [ [ 65, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60042" } ] }, { "id": "DS.d777.s0.e1", "type": "compound", "text": [ "xylobiose" ], "offsets": [ [ 207, 216 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439538" } ] } ]
[]
[]
[]
DS.d778
18703532
[ { "id": "DS.d778.s0", "type": "", "text": [ "Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells." ], "offsets": [ [ 0, 144 ] ] }, { "id": "DS.d778.s1", "type": "", "text": [ "Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A, thereby inhibiting platelet aggregation and inducing peripheral vasodilation." ], "offsets": [ [ 145, 367 ] ] }, { "id": "DS.d778.s2", "type": "", "text": [ "We hypothesized that cilostazol may prevent inflammatory cytokine induced-nuclear factor (NF)-kappaB activation by activating AMP-activated protein kinase (AMPK) in vascular endothelial cells." ], "offsets": [ [ 368, 560 ] ] } ]
[ { "id": "DS.d778.s0.e0", "type": "compound", "text": [ "Cilostazol" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2754" } ] }, { "id": "DS.d778.s0.e1", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 88, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d778.s1.e0", "type": "compound", "text": [ "Cilostazol" ], "offsets": [ [ 145, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2754" } ] }, { "id": "DS.d778.s1.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d778.s1.e2", "type": "protein", "text": [ "protein kinase A" ], "offsets": [ [ 272, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05608" }, { "db_name": "UniProt", "db_id": "Q9RI12" } ] }, { "id": "DS.d778.s2.e0", "type": "compound", "text": [ "cilostazol" ], "offsets": [ [ 389, 399 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2754" } ] }, { "id": "DS.d778.s2.e1", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 508, 522 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d778.s2.e2", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 524, 528 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] } ]
[]
[]
[ { "id": "DS.d778.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d778.s0.e0", "arg2_id": "DS.d778.s0.e1", "normalized": [] }, { "id": "DS.d778.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d778.s1.e0", "arg2_id": "DS.d778.s1.e2", "normalized": [] }, { "id": "DS.d778.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d778.s2.e0", "arg2_id": "DS.d778.s2.e2", "normalized": [] }, { "id": "DS.d778.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d778.s2.e0", "arg2_id": "DS.d778.s2.e1", "normalized": [] } ]
DS.d779
18703622
[ { "id": "DS.d779.s0", "type": "", "text": [ "Serum estradiol (E2) levels were not altered at any time point after IGF-I, demonstrating that the increased KiSS-1 expression observed was not caused by an elevation in E2." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "DS.d779.s0.e0", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 6, 15 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d779.s0.e1", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] } ]
[]
[]
[]
DS.d780
18703794
[ { "id": "DS.d780.s0", "type": "", "text": [ "A2aR stimulation inhibits HA fragment-induced pro-fibrotic genes TNF-alpha, keratinocyte chemoattractant (KC), macrophage inflammatory protein (MIP)-2, and MIP-1alpha while simultaneously synergizing with hyaluronan fragments to up-regulate the TH1 cytokine IL-12." ], "offsets": [ [ 0, 264 ] ] } ]
[ { "id": "DS.d780.s0.e0", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d780.s0.e1", "type": "protein", "text": [ "MIP" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06624" }, { "db_name": "UniProt", "db_id": "P28238" }, { "db_name": "UniProt", "db_id": "P30301" }, { "db_name": "UniProt", "db_id": "P35999" }, { "db_name": "UniProt", "db_id": "P37932" }, { "db_name": "UniProt", "db_id": "Q01992" }, { "db_name": "UniProt", "db_id": "Q09734" }, { "db_name": "UniProt", "db_id": "Q10415" }, { "db_name": "UniProt", "db_id": "Q6J8I9" }, { "db_name": "UniProt", "db_id": "Q6RZ07" }, { "db_name": "UniProt", "db_id": "Q92973" }, { "db_name": "UniProt", "db_id": "Q99797" } ] }, { "id": "DS.d780.s0.e2", "type": "protein", "text": [ "MIP-1alpha" ], "offsets": [ [ 156, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10147" }, { "db_name": "UniProt", "db_id": "P10855" }, { "db_name": "UniProt", "db_id": "P50229" }, { "db_name": "UniProt", "db_id": "Q5I1Z0" }, { "db_name": "UniProt", "db_id": "Q8HYQ3" }, { "db_name": "UniProt", "db_id": "Q8SQA6" } ] }, { "id": "DS.d780.s0.e3", "type": "compound", "text": [ "hyaluronan" ], "offsets": [ [ 205, 215 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" } ] } ]
[]
[]
[]
DS.d781
18703795
[ { "id": "DS.d781.s0", "type": "", "text": [ "In addition, treatment of primary mouse lung fibroblasts with ADMA stimulated arginase activity and collagen formation in vitro." ], "offsets": [ [ 0, 128 ] ] }, { "id": "DS.d781.s1", "type": "", "text": [ "These data support the idea that ADMA may play a role in airway diseases, including asthma and pulmonary fibrosis, through NOS inhibition and enhancement of arginase activity." ], "offsets": [ [ 129, 304 ] ] } ]
[ { "id": "DS.d781.s0.e0", "type": "compound", "text": [ "ADMA" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d781.s0.e1", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 78, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] }, { "id": "DS.d781.s1.e0", "type": "compound", "text": [ "ADMA" ], "offsets": [ [ 162, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d781.s1.e1", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 252, 255 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d781.s1.e2", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 286, 294 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] } ]
[]
[]
[ { "id": "DS.d781.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d781.s0.e0", "arg2_id": "DS.d781.s0.e1", "normalized": [] }, { "id": "DS.d781.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d781.s1.e0", "arg2_id": "DS.d781.s1.e2", "normalized": [] }, { "id": "DS.d781.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d781.s1.e0", "arg2_id": "DS.d781.s1.e1", "normalized": [] } ]
DS.d782
18703867
[ { "id": "DS.d782.s0", "type": "", "text": [ "Osteopontin (OPN) inhibits the growth of calcium oxalate monohydrate (COM) and other crystal phases in a phosphorylation-dependent manner." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "DS.d782.s0.e0", "type": "protein", "text": [ "OPN" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10451" }, { "db_name": "UniProt", "db_id": "P14287" }, { "db_name": "UniProt", "db_id": "P31096" }, { "db_name": "UniProt", "db_id": "Q9XSY9" } ] }, { "id": "DS.d782.s0.e1", "type": "compound", "text": [ "calcium oxalate monohydrate" ], "offsets": [ [ 41, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "971" } ] } ]
[]
[]
[ { "id": "DS.d782.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d782.s0.e1", "arg2_id": "DS.d782.s0.e0", "normalized": [] } ]
DS.d783
18703992
[ { "id": "DS.d783.s0", "type": "", "text": [ "Prostaglandins D2, E2, and F2alpha were increased in the tissues from mouse pups exposed to >95% O2 at 7 d indicating a differential expression of cyclooxygenase-2 products." ], "offsets": [ [ 0, 176 ] ] } ]
[ { "id": "DS.d783.s0.e0", "type": "compound", "text": [ "O2" ], "offsets": [ [ 100, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" }, { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d783.s0.e1", "type": "protein", "text": [ "cyclooxygenase-2" ], "offsets": [ [ 150, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] } ]
[]
[]
[ { "id": "DS.d783.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d783.s0.e0", "arg2_id": "DS.d783.s0.e1", "normalized": [] } ]
DS.d784
18704001
[ { "id": "DS.d784.s0", "type": "", "text": [ "Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction." ], "offsets": [ [ 0, 144 ] ] }, { "id": "DS.d784.s1", "type": "", "text": [ "Glucose stimulated insulin secretion (GSIS) was lower in the Glu group." ], "offsets": [ [ 145, 216 ] ] } ]
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DS.d785
18704095
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DS.d786
18704096
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DS.d787
18704103
[ { "id": "DS.d787.s0", "type": "", "text": [ "Here, we found that the addition of glucocorticoids, such as dexamethasone and cortisol, to cultured human keratinocytes increased their TLR2 gene expression." ], "offsets": [ [ 0, 158 ] ] }, { "id": "DS.d787.s1", "type": "", "text": [ "Gene expression of mitogen-activated protein kinase (MAPK) phosphatase-1 was also increased by the addition of dexamethasone." ], "offsets": [ [ 159, 284 ] ] } ]
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DS.d788
18704264
[ { "id": "DS.d788.s0", "type": "", "text": [ "Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C." ], "offsets": [ [ 0, 503 ] ] } ]
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"Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d788.s0.e9", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 422, 444 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d788.s0.e10", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 452, 471 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d788.s0.e11", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 473, 476 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d788.s0.e12", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 479, 488 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d788.s0.e13", "type": "compound", "text": [ "vitamin C" ], "offsets": [ [ 493, 502 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" } ] } ]
[]
[]
[]
DS.d789
18704417
[ { "id": "DS.d789.s0", "type": "", "text": [ "Achieving CCgR within 12 months and maintaining it without an increase in BCR-ABL transcripts might indicate that low-dose imatinib therapy can produce acceptable outcomes without excess toxicity." ], "offsets": [ [ 0, 196 ] ] } ]
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[]
[]
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DS.d790
18704487
[ { "id": "DS.d790.s0", "type": "", "text": [ "Rac1 (-/-) platelets displayed defective thrombus formation on collagen under flow conditions which could be fully restored by co-infusion of ADP and the TxA(2) analog U46619, indicating that impaired GPVI-, but not G-protein signaling, was responsible for the observed defect." ], "offsets": [ [ 0, 277 ] ] } ]
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[]
[]
[]
DS.d791
18704543
[ { "id": "DS.d791.s0", "type": "", "text": [ "LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake." ], "offsets": [ [ 0, 113 ] ] } ]
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[]
[]
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DS.d792
18704651
[ { "id": "DS.d792.s0", "type": "", "text": [ "Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen." ], "offsets": [ [ 0, 186 ] ] } ]
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[]
[]
[ { "id": "DS.d792.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d792.s0.e0", "arg2_id": "DS.d792.s0.e2", "normalized": [] } ]
DS.d793
18704653
[ { "id": "DS.d793.s0", "type": "", "text": [ "Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d793.s1", "type": "", "text": [ "To explore the possibility of controlling cell interaction with biomaterials, tricalcium phosphate scaffolds were modified using the enzyme tissue transglutaminase (tTgase) in conjunction with fibronectin." ], "offsets": [ [ 116, 321 ] ] } ]
[ { "id": "DS.d793.s0.e0", "type": "protein", "text": [ "tissue transglutaminase" ], "offsets": [ [ 7, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08587" }, { "db_name": "UniProt", "db_id": "P21980" }, { "db_name": "UniProt", "db_id": "P21981" }, { "db_name": "UniProt", "db_id": "P51176" }, { "db_name": "UniProt", "db_id": "P52181" }, { "db_name": "UniProt", "db_id": "Q01841" } ] }, { "id": "DS.d793.s0.e1", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 35, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] }, { "id": "DS.d793.s0.e2", "type": "compound", "text": [ "tricalcium phosphate" ], "offsets": [ [ 84, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24456" } ] }, { "id": "DS.d793.s1.e0", "type": "compound", "text": [ "tricalcium phosphate" ], "offsets": [ [ 194, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24456" } ] }, { "id": "DS.d793.s1.e1", "type": "protein", "text": [ "tissue transglutaminase" ], "offsets": [ [ 256, 279 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08587" }, { "db_name": "UniProt", "db_id": "P21980" }, { "db_name": "UniProt", "db_id": "P21981" }, { "db_name": "UniProt", "db_id": "P51176" }, { "db_name": "UniProt", "db_id": "P52181" }, { "db_name": "UniProt", "db_id": "Q01841" } ] }, { "id": "DS.d793.s1.e2", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 309, 320 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] } ]
[]
[]
[ { "id": "DS.d793.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d793.s0.e2", "arg2_id": "DS.d793.s0.e0", "normalized": [] }, { "id": "DS.d793.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d793.s0.e2", "arg2_id": "DS.d793.s0.e1", "normalized": [] }, { "id": "DS.d793.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d793.s1.e0", "arg2_id": "DS.d793.s1.e1", "normalized": [] }, { "id": "DS.d793.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d793.s1.e0", "arg2_id": "DS.d793.s1.e2", "normalized": [] } ]
DS.d796
18704766
[ { "id": "DS.d796.s0", "type": "", "text": [ "Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment." ], "offsets": [ [ 0, 258 ] ] }, { "id": "DS.d796.s1", "type": "", "text": [ "Hence, MPTP lesion, L-DOPA treatment and prevention of LID with CI-1041 and cabergoline, or reduction with Ro 61-8048 were associated with modulation of NR2B/NMDA glutamate receptors." ], "offsets": [ [ 259, 442 ] ] } ]
[ { "id": "DS.d796.s0.e0", "type": "compound", "text": [ "L-DOPA" ], "offsets": [ [ 27, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6047" } ] }, { "id": "DS.d796.s0.e1", "type": "compound", "text": [ "Benserazide" ], "offsets": [ [ 34, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2327" } ] }, { "id": "DS.d796.s0.e2", "type": "protein", "text": [ "NR1" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11605" }, { "db_name": "UniProt", "db_id": "P11832" }, { "db_name": "UniProt", "db_id": "P16081" }, { "db_name": "UniProt", "db_id": "P39865" }, { "db_name": "UniProt", "db_id": "Q9SML8" } ] }, { "id": "DS.d796.s0.e3", "type": "protein", "text": [ "NR2B" ], "offsets": [ [ 96, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00960" }, { "db_name": "UniProt", "db_id": "Q01097" }, { "db_name": "UniProt", "db_id": "Q13224" } ] }, { "id": "DS.d796.s0.e4", "type": "compound", "text": [ "L-DOPA" ], "offsets": [ [ 128, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6047" } ] }, { "id": "DS.d796.s0.e5", "type": "compound", "text": [ "Benserazide" ], "offsets": [ [ 135, 146 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2327" } ] }, { "id": "DS.d796.s0.e6", "type": "compound", "text": [ "cabergoline" ], "offsets": [ [ 168, 179 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54746" } ] }, { "id": "DS.d796.s1.e0", "type": "compound", "text": [ "L-DOPA" ], "offsets": [ [ 279, 285 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6047" } ] }, { "id": "DS.d796.s1.e1", "type": "compound", "text": [ "cabergoline" ], "offsets": [ [ 335, 346 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54746" } ] }, { "id": "DS.d796.s1.e2", "type": "compound", "text": [ "Ro 61-8048" ], "offsets": [ [ 366, 376 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282337" } ] }, { "id": "DS.d796.s1.e3", "type": "protein", "text": [ "NR2B" ], "offsets": [ [ 412, 416 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00960" }, { "db_name": "UniProt", "db_id": "Q01097" }, { "db_name": "UniProt", "db_id": "Q13224" } ] } ]
[]
[]
[ { "id": "DS.d796.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d796.s1.e2", "arg2_id": "DS.d796.s1.e3", "normalized": [] }, { "id": "DS.d796.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d796.s1.e0", "arg2_id": "DS.d796.s1.e3", "normalized": [] }, { "id": "DS.d796.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d796.s1.e1", "arg2_id": "DS.d796.s1.e3", "normalized": [] } ]
DS.d797
18704940
[ { "id": "DS.d797.s0", "type": "", "text": [ "MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase), a three-domain bacterial protein, catalyses a highly specific incorporation of D-glutamate to the cytoplasmic intermediate UDP-N-acetyl-muramoyl-L-alanine (UMA) utilizing ATP hydrolysis to ADP and P(i)." ], "offsets": [ [ 0, 260 ] ] }, { "id": "DS.d797.s1", "type": "", "text": [ "On the basis of structural studies of MurD complexes, a stepwise catalytic mechanism was proposed that commences with a formation of the acyl-phosphate intermediate, followed by a nucleophilic attack of D-glutamate that, through the formation of a tetrahedral reaction intermediate and subsequent phosphate dissociation, affords the final product, UDP-N-acetyl-muramoyl-L-alanine-D-glutamate (UMAG)." ], "offsets": [ [ 261, 660 ] ] } ]
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"db_id": "Q8Z9H0" }, { "db_name": "UniProt", "db_id": "Q8ZIF1" }, { "db_name": "UniProt", "db_id": "Q8ZRU4" }, { "db_name": "UniProt", "db_id": "Q929Y1" }, { "db_name": "UniProt", "db_id": "Q92I60" }, { "db_name": "UniProt", "db_id": "Q97EB9" }, { "db_name": "UniProt", "db_id": "Q97RU8" }, { "db_name": "UniProt", "db_id": "Q98KB1" }, { "db_name": "UniProt", "db_id": "Q9A597" }, { "db_name": "UniProt", "db_id": "Q9CF91" }, { "db_name": "UniProt", "db_id": "Q9CPB0" }, { "db_name": "UniProt", "db_id": "Q9F1N2" }, { "db_name": "UniProt", "db_id": "Q9HVZ9" }, { "db_name": "UniProt", "db_id": "Q9JSZ5" }, { "db_name": "UniProt", "db_id": "Q9K0Y4" }, { "db_name": "UniProt", "db_id": "Q9K9S8" }, { "db_name": "UniProt", "db_id": "Q9KPG5" }, { "db_name": "UniProt", "db_id": "Q9PEB0" }, { "db_name": "UniProt", "db_id": "Q9PI73" }, { "db_name": "UniProt", "db_id": "Q9PLG5" }, { "db_name": "UniProt", "db_id": "Q9RRJ4" }, { "db_name": "UniProt", "db_id": "Q9S2W9" }, { "db_name": "UniProt", "db_id": "Q9WY76" }, { "db_name": "UniProt", "db_id": "Q9Z705" }, { "db_name": "UniProt", "db_id": "Q9ZDC2" }, { "db_name": "UniProt", "db_id": "Q9ZLY0" } ] }, { "id": "DS.d797.s1.e2", "type": "compound", "text": [ "D-glutamate" ], "offsets": [ [ 464, 475 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23327" } ] } ]
[]
[]
[ { "id": "DS.d797.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d797.s0.e1", "arg2_id": "DS.d797.s0.e0", "normalized": [] }, { "id": "DS.d797.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d797.s1.e2", "arg2_id": "DS.d797.s1.e0", "normalized": [] } ]
DS.d798
18704946
[ { "id": "DS.d798.s0", "type": "", "text": [ "Although the overall amino acid identity between SERTs and the LeuT(Aa) is only 17%, it increases to above 50% in the first shell of the putative 5-HT binding site, allowing de novo computational docking of tryptamine derivatives in atomic detail." ], "offsets": [ [ 0, 247 ] ] } ]
[ { "id": "DS.d798.s0.e0", "type": "protein", "text": [ "SERTs" ], "offsets": [ [ 49, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] }, { "id": "DS.d798.s0.e1", "type": "compound", "text": [ "tryptamine" ], "offsets": [ [ 207, 217 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1150" } ] } ]
[]
[]
[]
DS.d799
18704953
[ { "id": "DS.d799.s0", "type": "", "text": [ "Mal-sCT, prepared by conjugating sCT via thio-ether bonds with aqueous-soluble palmitic acid derivative at Cys 1 and Cys 7, was reacted with mPEG-succinimide (mPEG-Suc, 5 kDa)." ], "offsets": [ [ 0, 176 ] ] } ]
[ { "id": "DS.d799.s0.e0", "type": "protein", "text": [ "sCT" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P56862" } ] }, { "id": "DS.d799.s0.e1", "type": "protein", "text": [ "sCT" ], "offsets": [ [ 33, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P56862" } ] }, { "id": "DS.d799.s0.e3", "type": "compound", "text": [ "palmitic acid" ], "offsets": [ [ 79, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "985" } ] }, { "id": "DS.d799.s0.e4", "type": "compound", "text": [ "mPEG" ], "offsets": [ [ 141, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8019" } ] }, { "id": "DS.d799.s0.e5", "type": "compound", "text": [ "succinimide" ], "offsets": [ [ 146, 157 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11439" } ] }, { "id": "DS.d799.s0.e6", "type": "compound", "text": [ "mPEG" ], "offsets": [ [ 159, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8019" } ] } ]
[]
[]
[ { "id": "DS.d799.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d799.s0.e5", "arg2_id": "DS.d799.s0.e0", "normalized": [] }, { "id": "DS.d799.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d799.s0.e3", "arg2_id": "DS.d799.s0.e0", "normalized": [] }, { "id": "DS.d799.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d799.s0.e4", "arg2_id": "DS.d799.s0.e0", "normalized": [] } ]
DS.d800
18704955
[ { "id": "DS.d800.s0", "type": "", "text": [ "Our findings suggest that GLP-1 substituted with a PEG of an appropriate Mw at Lys (34) could be used as a promising type 2 anti-diabetic agent to timely control postprandial glucose levels." ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "DS.d800.s0.e0", "type": "protein", "text": [ "GLP-1" ], "offsets": [ [ 26, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q06605" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] }, { "id": "DS.d800.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 175, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d800.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d800.s0.e1", "arg2_id": "DS.d800.s0.e0", "normalized": [] } ]
DS.d801
18706130
[ { "id": "DS.d801.s0", "type": "", "text": [ "The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d801.s0.e0", "type": "compound", "text": [ "agomelatine" ], "offsets": [ [ 19, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "82148" } ] }, { "id": "DS.d801.s0.e1", "type": "protein", "text": [ "NCAM" ], "offsets": [ [ 158, 162 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13591" }, { "db_name": "UniProt", "db_id": "P13592" }, { "db_name": "UniProt", "db_id": "P31836" } ] } ]
[]
[]
[ { "id": "DS.d801.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d801.s0.e0", "arg2_id": "DS.d801.s0.e1", "normalized": [] } ]
DS.d802
18706695
[ { "id": "DS.d802.s0", "type": "", "text": [ "Phosphatase activity was also inhibited for all the soils treated with triclosan (from 0.1 to 50mg/kg dry soil), but a declining inhibition was observed after 2 days of incubation." ], "offsets": [ [ 0, 180 ] ] } ]
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[]
[]
[ { "id": "DS.d802.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d802.s0.e1", "arg2_id": "DS.d802.s0.e0", "normalized": [] } ]
DS.d804
18706940
[ { "id": "DS.d804.s0", "type": "", "text": [ "The magnitude of autophagosome formation is tightly regulated by intracellular and extracellular amino acid concentrations and ATP levels via signaling pathways that include the nutrient sensing kinase TOR." ], "offsets": [ [ 0, 206 ] ] } ]
[ { "id": "DS.d804.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 127, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d804.s0.e1", "type": "protein", "text": [ "TOR" ], "offsets": [ [ 202, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51450" } ] } ]
[]
[]
[ { "id": "DS.d804.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d804.s0.e0", "arg2_id": "DS.d804.s0.e1", "normalized": [] } ]
DS.d805
18707755
[ { "id": "DS.d805.s0", "type": "", "text": [ "Normoglycemic (4.72 mmol/L), moderate (11.1 mmol/L) or high grade (16.7 mmol/L) glucose clamps were maintained for 6 hours by infusion of glucose, insulin and somatostatin." ], "offsets": [ [ 0, 172 ] ] } ]
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[]
[]
[]
DS.d806
18708066
[ { "id": "DS.d806.s0", "type": "", "text": [ "or=6 ng/ml) was associated with increased expression of mrp-1 and pgp-1 and decreased glutathione, while higher level resistance (10 ng/ml) was primarily associated with the increased expression of P-glycoproteins." ], "offsets": [ [ 0, 214 ] ] } ]
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[]
[]
[]
DS.d807
18708157
[ { "id": "DS.d807.s0", "type": "", "text": [ "Co(2+) also induces the release of the pro-apoptotic factors, cytochrome c and AIF." ], "offsets": [ [ 0, 83 ] ] }, { "id": "DS.d807.s1", "type": "", "text": [ "Incubation of rat hepatocyte primary cultures with Co(2+) results in apoptosis induction with caspase activation and increased level of expression of HIF-1alpha." ], "offsets": [ [ 84, 245 ] ] } ]
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"db_id": "O35800" }, { "db_name": "UniProt", "db_id": "Q0PGG7" }, { "db_name": "UniProt", "db_id": "Q16665" }, { "db_name": "UniProt", "db_id": "Q309Z6" }, { "db_name": "UniProt", "db_id": "Q61221" }, { "db_name": "UniProt", "db_id": "Q98SW2" }, { "db_name": "UniProt", "db_id": "Q9I8A9" }, { "db_name": "UniProt", "db_id": "Q9XTA5" }, { "db_name": "UniProt", "db_id": "Q9YIB9" } ] } ]
[]
[]
[ { "id": "DS.d807.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d807.s0.e0", "arg2_id": "DS.d807.s0.e1", "normalized": [] }, { "id": "DS.d807.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d807.s0.e0", "arg2_id": "DS.d807.s0.e2", "normalized": [] }, { "id": "DS.d807.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d807.s1.e0", "arg2_id": "DS.d807.s1.e1", "normalized": [] } ]
DS.d808
18708158
[ { "id": "DS.d808.s0", "type": "", "text": [ "Roscovitine reduced amounts of the caspase inhibitor XIAP, and API-2 increased amounts of the BH3-only protein Bim." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d808.s1", "type": "", "text": [ "Bax accumulated in mitochondria in response to API-2, whereas release of cytochrome c from mitochondria required both API-2 and roscovitine." ], "offsets": [ [ 116, 256 ] ] }, { "id": "DS.d808.s2", "type": "", "text": [ "We suggest that roscovitine elicits events that activate Bax once it translocates to mitochondria and that inactivation of cdk9 signals these events and the down-regulation of XIAP." ], "offsets": [ [ 257, 438 ] ] } ]
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"P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d808.s1.e2", "type": "compound", "text": [ "roscovitine" ], "offsets": [ [ 244, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "160355" } ] }, { "id": "DS.d808.s2.e0", "type": "compound", "text": [ "roscovitine" ], "offsets": [ [ 273, 284 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "160355" } ] }, { "id": "DS.d808.s2.e1", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 314, 317 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d808.s2.e2", "type": "protein", "text": [ "cdk9" ], "offsets": [ [ 380, 384 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q641Z4" }, { "db_name": "UniProt", "db_id": "Q6GLD8" }, { "db_name": "UniProt", "db_id": "Q96WV9" }, { "db_name": "UniProt", "db_id": "Q99J95" } ] } ]
[]
[]
[ { "id": "DS.d808.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d808.s1.e2", "arg2_id": "DS.d808.s1.e1", "normalized": [] }, { "id": "DS.d808.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d808.s2.e0", "arg2_id": "DS.d808.s2.e2", "normalized": [] }, { "id": "DS.d808.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d808.s2.e0", "arg2_id": "DS.d808.s2.e1", "normalized": [] } ]
DS.d809
18708191
[ { "id": "DS.d809.s0", "type": "", "text": [ "Intravenous glutamine enhances COX-2 activity giving cardioprotection." ], "offsets": [ [ 0, 70 ] ] }, { "id": "DS.d809.s1", "type": "", "text": [ "We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning." ], "offsets": [ [ 71, 230 ] ] } ]
[ { "id": "DS.d809.s0.e0", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 12, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d809.s0.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d809.s1.e0", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 113, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d809.s1.e1", "type": "protein", "text": [ "COX" ], "offsets": [ [ 161, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11353" }, { "db_name": "UniProt", "db_id": "P36551" }, { "db_name": "UniProt", "db_id": "P36552" }, { "db_name": "UniProt", "db_id": "Q9UTE2" }, { "db_name": "UniProt", "db_id": "Q9V3D2" } ] }, { "id": "DS.d809.s1.e2", "type": "protein", "text": [ "HSP" ], "offsets": [ [ 192, 195 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32590" } ] } ]
[]
[]
[ { "id": "DS.d809.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d809.s0.e0", "arg2_id": "DS.d809.s0.e1", "normalized": [] }, { "id": "DS.d809.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d809.s1.e0", "arg2_id": "DS.d809.s1.e2", "normalized": [] }, { "id": "DS.d809.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d809.s1.e0", "arg2_id": "DS.d809.s1.e1", "normalized": [] } ]
DS.d810
18708284
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"P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d810.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e1", "normalized": [] }, { "id": "DS.d810.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e7", "normalized": [] }, { "id": "DS.d810.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e8", "normalized": [] }, { "id": "DS.d810.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e6", "normalized": [] }, { "id": "DS.d810.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e9", "normalized": [] }, { "id": "DS.d810.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s0.e0", "arg2_id": "DS.d810.s0.e5", "normalized": [] }, { "id": "DS.d810.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s1.e0", "arg2_id": "DS.d810.s1.e3", "normalized": [] }, { "id": "DS.d810.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s1.e2", "arg2_id": "DS.d810.s1.e3", "normalized": [] }, { "id": "DS.d810.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s1.e2", "arg2_id": "DS.d810.s1.e1", "normalized": [] }, { "id": "DS.d810.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s2.e0", "arg2_id": "DS.d810.s2.e2", "normalized": [] }, { "id": "DS.d810.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s2.e1", "arg2_id": "DS.d810.s2.e2", "normalized": [] }, { "id": "DS.d810.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d810.s3.e0", "arg2_id": "DS.d810.s3.e1", "normalized": [] } ]
DS.d811
18708285
[ { "id": "DS.d811.s0", "type": "", "text": [ "Furthermore, treatment of lycopene and EPA also synergistically blocked the activation of downstream mTOR molecule." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d811.s1", "type": "", "text": [ "Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival." ], "offsets": [ [ 116, 296 ] ] } ]
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[]
[]
[ { "id": "DS.d811.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d811.s0.e0", "arg2_id": "DS.d811.s0.e1", "normalized": [] }, { "id": "DS.d811.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d811.s1.e0", "arg2_id": "DS.d811.s1.e1", "normalized": [] }, { "id": "DS.d811.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d811.s1.e0", "arg2_id": "DS.d811.s1.e2", "normalized": [] } ]
DS.d812
18709446
[ { "id": "DS.d812.s0", "type": "", "text": [ "Amino acids (alanine, aspartic acid, glutamic acid) and glucose oxidase (GOx) were adsorbed on CNF and the results were compared with those obtained when activated carbon (AC) was used as support." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "DS.d812.s0.e0", "type": "compound", "text": [ "alanine" ], "offsets": [ [ 13, 20 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "602" }, { "db_name": "PubChem", "db_id": "4580" }, { "db_name": "PubChem", "db_id": "5950" }, { "db_name": "PubChem", "db_id": "71080" } ] }, { "id": "DS.d812.s0.e1", "type": "compound", "text": [ "aspartic acid" ], "offsets": [ [ 22, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "424" }, { "db_name": "PubChem", "db_id": "5960" }, { "db_name": "PubChem", "db_id": "83887" } ] }, { "id": "DS.d812.s0.e2", "type": "protein", "text": [ "glucose oxidase" ], "offsets": [ [ 56, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81156" } ] }, { "id": "DS.d812.s0.e3", "type": "compound", "text": [ "activated carbon" ], "offsets": [ [ 154, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "297" } ] } ]
[]
[]
[]
DS.d814
18709646
[ { "id": "DS.d814.s0", "type": "", "text": [ "The NSCs and neuroblasts had epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor alpha (PDGFRalpha) expressed on the ciliary apparatus and were the only cell types incorporating the proliferation marker BrdU." ], "offsets": [ [ 0, 240 ] ] }, { "id": "DS.d814.s1", "type": "", "text": [ "Ependymal and displaced ependymal cells also expressed EGFR and PDGFRalpha on their cilia but did not incorporate BrdU." ], "offsets": [ [ 241, 360 ] ] } ]
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[]
[]
[]
DS.d815
18709647
[ { "id": "DS.d815.s0", "type": "", "text": [ "Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "DS.d815.s0.e0", "type": "compound", "text": [ "17beta-estradiol" ], "offsets": [ [ 18, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d815.s0.e1", "type": "protein", "text": [ "p42" ], "offsets": [ [ 69, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46672" }, { "db_name": "UniProt", "db_id": "Q27272" }, { "db_name": "UniProt", "db_id": "Q8NFH3" }, { "db_name": "UniProt", "db_id": "Q9SB81" } ] }, { "id": "DS.d815.s0.e2", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d815.s0.e3", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18266" }, { "db_name": "UniProt", "db_id": "P49841" }, { "db_name": "UniProt", "db_id": "Q5YJC2" }, { "db_name": "UniProt", "db_id": "Q9WV60" } ] } ]
[]
[]
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DS.d816
18709649
[ { "id": "DS.d816.s0", "type": "", "text": [ "Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development." ], "offsets": [ [ 0, 226 ] ] } ]
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[]
[]
[ { "id": "DS.d816.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d816.s0.e3", "arg2_id": "DS.d816.s0.e1", "normalized": [] }, { "id": "DS.d816.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d816.s0.e2", "arg2_id": "DS.d816.s0.e1", "normalized": [] }, { "id": "DS.d816.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d816.s0.e0", "arg2_id": "DS.d816.s0.e1", "normalized": [] } ]
DS.d817
18709661
[ { "id": "DS.d817.s0", "type": "", "text": [ "Accordingly, the TLR3 agonist poly(I:C) (PIC) induced higher release of IFN-beta in primary and purified astroglia than in microglia." ], "offsets": [ [ 0, 133 ] ] }, { "id": "DS.d817.s1", "type": "", "text": [ "As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression." ], "offsets": [ [ 134, 223 ] ] } ]
[ { "id": "DS.d817.s0.e0", "type": "compound", "text": [ "poly(I:C" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "32744" }, { "db_name": "PubChem", "db_id": "213546" }, { "db_name": "PubChem", "db_id": "274740" } ] }, { "id": "DS.d817.s0.e1", "type": "compound", "text": [ "PIC" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1854" } ] }, { "id": "DS.d817.s0.e2", "type": "protein", "text": [ "IFN-beta" ], "offsets": [ [ 72, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77812" }, { "db_name": "UniProt", "db_id": "P01574" }, { "db_name": "UniProt", "db_id": "P01575" }, { "db_name": "UniProt", "db_id": "P05012" }, { "db_name": "UniProt", "db_id": "P70499" }, { "db_name": "UniProt", "db_id": "Q6XZW6" }, { "db_name": "UniProt", "db_id": "Q9N2J0" } ] }, { "id": "DS.d817.s1.e0", "type": "compound", "text": [ "PIC" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1854" } ] }, { "id": "DS.d817.s1.e1", "type": "protein", "text": [ "IP-10" ], "offsets": [ [ 156, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02778" }, { "db_name": "UniProt", "db_id": "P17515" }, { "db_name": "UniProt", "db_id": "P48973" } ] }, { "id": "DS.d817.s1.e2", "type": "protein", "text": [ "Stat1" ], "offsets": [ [ 163, 168 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42225" } ] }, { "id": "DS.d817.s1.e3", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 170, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] }, { "id": "DS.d817.s1.e4", "type": "protein", "text": [ "Cox-2" ], "offsets": [ [ 182, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00411" }, { "db_name": "UniProt", "db_id": "P24894" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "Q05769" }, { "db_name": "UniProt", "db_id": "Q8HEC3" }, { "db_name": "UniProt", "db_id": "Q8SEM9" } ] }, { "id": "DS.d817.s1.e5", "type": "protein", "text": [ "TLR3" ], "offsets": [ [ 202, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15455" }, { "db_name": "UniProt", "db_id": "Q0PV50" }, { "db_name": "UniProt", "db_id": "Q5TJ59" } ] } ]
[]
[]
[ { "id": "DS.d817.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s0.e0", "arg2_id": "DS.d817.s0.e2", "normalized": [] }, { "id": "DS.d817.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s0.e1", "arg2_id": "DS.d817.s0.e2", "normalized": [] }, { "id": "DS.d817.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s1.e0", "arg2_id": "DS.d817.s1.e1", "normalized": [] }, { "id": "DS.d817.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s1.e0", "arg2_id": "DS.d817.s1.e3", "normalized": [] }, { "id": "DS.d817.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s1.e0", "arg2_id": "DS.d817.s1.e2", "normalized": [] }, { "id": "DS.d817.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s1.e0", "arg2_id": "DS.d817.s1.e5", "normalized": [] }, { "id": "DS.d817.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d817.s1.e0", "arg2_id": "DS.d817.s1.e4", "normalized": [] } ]
DS.d818
18710402
[ { "id": "DS.d818.s0", "type": "", "text": [ "Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4 (+) T lymphocytes." ], "offsets": [ [ 0, 186 ] ] }, { "id": "DS.d818.s1", "type": "", "text": [ "During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade." ], "offsets": [ [ 187, 342 ] ] }, { "id": "DS.d818.s2", "type": "", "text": [ "Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS)." ], "offsets": [ [ 343, 568 ] ] } ]
[ { "id": "DS.d818.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 32, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d818.s0.e1", "type": "protein", "text": [ "antigen-4" ], "offsets": [ [ 120, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31522" }, { "db_name": "UniProt", "db_id": "Q26721" }, { "db_name": "UniProt", "db_id": "Q56982" } ] }, { "id": "DS.d818.s0.e2", "type": "protein", "text": [ "CD152" ], "offsets": [ [ 131, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16410" } ] }, { "id": "DS.d818.s0.e3", "type": "protein", "text": [ "CD80" ], "offsets": [ [ 138, 142 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33681" }, { "db_name": "UniProt", "db_id": "P42070" } ] }, { "id": "DS.d818.s0.e4", "type": "protein", "text": [ "CD86" ], "offsets": [ [ 143, 147 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42071" }, { "db_name": "UniProt", "db_id": "P42081" } ] }, { "id": "DS.d818.s1.e0", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d818.s1.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 278, 282 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d818.s1.e2", "type": "protein", "text": [ "CTLA-4" ], "offsets": [ [ 316, 322 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09793" }, { "db_name": "UniProt", "db_id": "P16410" }, { "db_name": "UniProt", "db_id": "P42072" }, { "db_name": "UniProt", "db_id": "Q9MYX7" }, { "db_name": "UniProt", "db_id": "Q9XSI1" } ] }, { "id": "DS.d818.s1.e3", "type": "protein", "text": [ "CD80" ], "offsets": [ [ 323, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33681" }, { "db_name": "UniProt", "db_id": "P42070" } ] }, { "id": "DS.d818.s1.e4", "type": "protein", "text": [ "CD86" ], "offsets": [ [ 328, 332 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42071" }, { "db_name": "UniProt", "db_id": "P42081" } ] }, { "id": "DS.d818.s2.e0", "type": "protein", "text": [ "CTLA-4" ], "offsets": [ [ 381, 387 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09793" }, { "db_name": "UniProt", "db_id": "P16410" }, { "db_name": "UniProt", "db_id": "P42072" }, { "db_name": "UniProt", "db_id": "Q9MYX7" }, { "db_name": "UniProt", "db_id": "Q9XSI1" } ] }, { "id": "DS.d818.s2.e1", "type": "protein", "text": [ "CD80" ], "offsets": [ [ 388, 392 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33681" }, { "db_name": "UniProt", "db_id": "P42070" } ] }, { "id": "DS.d818.s2.e2", "type": "protein", "text": [ "CD86" ], "offsets": [ [ 393, 397 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42071" }, { "db_name": "UniProt", "db_id": "P42081" } ] }, { "id": "DS.d818.s2.e3", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 453, 456 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d818.s2.e4", "type": "compound", "text": [ "SOS" ], "offsets": [ [ 491, 494 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8885" } ] }, { "id": "DS.d818.s2.e5", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 527, 530 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d818.s2.e6", "type": "compound", "text": [ "SOS" ], "offsets": [ [ 563, 566 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8885" } ] } ]
[]
[]
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DS.d819
18710604
[ { "id": "DS.d819.s0", "type": "", "text": [ "FSO decreased fasting glucose by 20 % and liver weights by 37 % compared with those in the CLA group; it maintained circulating insulin, HOMA1-IR and HOMA1 for beta cell function at levels found in the control group." ], "offsets": [ [ 0, 216 ] ] } ]
[ { "id": "DS.d819.s0.e0", "type": "compound", "text": [ "FSO" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288258" } ] }, { "id": "DS.d819.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 22, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d819.s0.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 128, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d819.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d819.s0.e0", "arg2_id": "DS.d819.s0.e2", "normalized": [] } ]
DS.d820
18710606
[ { "id": "DS.d820.s0", "type": "", "text": [ "Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component." ], "offsets": [ [ 0, 162 ] ] }, { "id": "DS.d820.s1", "type": "", "text": [ "The purpose of this study was to investigate the effect of dietary supplementation with EGCG on insulin resistance and associated metabolic risk factors in man." ], "offsets": [ [ 163, 323 ] ] }, { "id": "DS.d820.s2", "type": "", "text": [ "EGCG treatment had no effect on insulin sensitivity, insulin secretion or glucose tolerance but did reduce diastolic blood pressure (mean change: placebo-0.058 (se 0.75) mmHg; EGCG-2.68 (se 0.72) mmHg; P = 0.014)." ], "offsets": [ [ 324, 537 ] ] }, { "id": "DS.d820.s3", "type": "", "text": [ "In conclusion, regular intake of EGCG had no effect on insulin resistance but did result in a modest reduction in diastolic blood pressure." ], "offsets": [ [ 538, 677 ] ] } ]
[ { "id": "DS.d820.s0.e0", "type": "compound", "text": [ "green tea" ], "offsets": [ [ 31, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4630" } ] }, { "id": "DS.d820.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 54, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d820.s0.e2", "type": "compound", "text": [ "epigallocatechin-3-gallate" ], "offsets": [ [ 80, 106 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s0.e3", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 108, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s1.e0", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 251, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s1.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 259, 266 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d820.s2.e0", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 324, 328 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s2.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 356, 363 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d820.s2.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 377, 384 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d820.s2.e3", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 398, 405 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d820.s2.e4", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 500, 504 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s3.e0", "type": "compound", "text": [ "EGCG" ], "offsets": [ [ 571, 575 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d820.s3.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 593, 600 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d820.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d820.s1.e0", "arg2_id": "DS.d820.s1.e1", "normalized": [] } ]
DS.d821
18710702
[ { "id": "DS.d821.s0", "type": "", "text": [ "We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ER (alpha), ER (beta)), P receptors (PR(B), PR(A+B)), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi." ], "offsets": [ [ 0, 357 ] ] } ]
[ { "id": "DS.d821.s0.e0", "type": "compound", "text": [ "levonorgestrel" ], "offsets": [ [ 56, 70 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "13109" } ] }, { "id": "DS.d821.s0.e1", "type": "protein", "text": [ "estrogen receptors" ], "offsets": [ [ 180, 198 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d821.s0.e2", "type": "protein", "text": [ "androgen receptor" ], "offsets": [ [ 254, 271 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97775" }, { "db_name": "UniProt", "db_id": "O97776" }, { "db_name": "UniProt", "db_id": "O97952" }, { "db_name": "UniProt", "db_id": "O97960" }, { "db_name": "UniProt", "db_id": "P10275" }, { "db_name": "UniProt", "db_id": "P15207" }, { "db_name": "UniProt", "db_id": "P19091" }, { "db_name": "UniProt", "db_id": "P49699" }, { "db_name": "UniProt", "db_id": "Q6QT55" }, { "db_name": "UniProt", "db_id": "Q7T1K4" }, { "db_name": "UniProt", "db_id": "Q8MIK0" }, { "db_name": "UniProt", "db_id": "Q9GKL7" }, { "db_name": "UniProt", "db_id": "Q9TT90" } ] } ]
[]
[]
[]
DS.d822
18710819
[ { "id": "DS.d822.s0", "type": "", "text": [ "5-FU effect on HS cell viability was markedly reduced in hypoxic condition without an induction of chemoresistant related protein, P-glycoprotein." ], "offsets": [ [ 0, 146 ] ] } ]
[ { "id": "DS.d822.s0.e0", "type": "compound", "text": [ "5-FU" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3385" } ] }, { "id": "DS.d822.s0.e1", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 133, 145 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[]
DS.d823
18710908
[ { "id": "DS.d823.s0", "type": "", "text": [ "High-level toxin production occurred after detectable spore germination in all experiments except those with C. difficile PCR ribotype 027 and moxifloxacin, in which marked cytotoxin production preceded detectable germination, which coincided with isolate recovery on fluoroquinolone-containing medium." ], "offsets": [ [ 0, 302 ] ] } ]
[ { "id": "DS.d823.s0.e0", "type": "compound", "text": [ "moxifloxacin" ], "offsets": [ [ 143, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "152946" } ] }, { "id": "DS.d823.s0.e1", "type": "protein", "text": [ "cytotoxin" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07845" }, { "db_name": "UniProt", "db_id": "P81662" } ] } ]
[]
[]
[]
DS.d824
18711728
[ { "id": "DS.d824.s0", "type": "", "text": [ "Furthermore, Ngb overexpression reduced superoxide anion generation after H/R, whereas glutathione levels were significantly improved compared with WT controls." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d824.s0.e0", "type": "protein", "text": [ "Ngb" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q90YJ2" }, { "db_name": "UniProt", "db_id": "Q99JA8" }, { "db_name": "UniProt", "db_id": "Q9ER97" } ] }, { "id": "DS.d824.s0.e1", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 40, 50 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d824.s0.e2", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 87, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[ { "id": "DS.d824.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d824.s0.e1", "arg2_id": "DS.d824.s0.e0", "normalized": [] }, { "id": "DS.d824.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d824.s0.e2", "arg2_id": "DS.d824.s0.e0", "normalized": [] } ]
DS.d825
18711746
[ { "id": "DS.d825.s0", "type": "", "text": [ "Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration." ], "offsets": [ [ 0, 233 ] ] }, { "id": "DS.d825.s1", "type": "", "text": [ "The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days." ], "offsets": [ [ 234, 548 ] ] }, { "id": "DS.d825.s2", "type": "", "text": [ "Although the 5-HT levels in hippocampus (HC) and hypothalamus (HT) were not altered, the PKC-alpha expression and PKC 0.05) in level in HC." ], "offsets": [ [ 549, 688 ] ] } ]
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[]
[]
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DS.d826
18711749
[ { "id": "DS.d826.s0", "type": "", "text": [ "We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke." ], "offsets": [ [ 0, 339 ] ] }, { "id": "DS.d826.s1", "type": "", "text": [ "To elucidate whether SDF1/CXCR4 and Ang1/Tie2 pathways mediate DETA-NONOate-induced SVZ migration after stroke, SDF1alpha, Ang1 peptide, a specific antagonist of CXCR4 (AMD3100), and a neutralizing antibody of Tie2 (anti-Tie2) were used in vitro." ], "offsets": [ [ 340, 586 ] ] }, { "id": "DS.d826.s2", "type": "", "text": [ "DETA-NONOate significantly increased the expression of SDF1 and Ang1 in the ischemic border and up-regulated CXCR4 and Tie2 in the SVZ compared with MCAo control." ], "offsets": [ [ 587, 749 ] ] }, { "id": "DS.d826.s3", "type": "", "text": [ "Our data indicate that treatment of stroke with a nitric oxide donor up-regulates SDF1/CXCR4 and Ang1/Tie2 pathways and thereby likely increases SVZ neuroblast cell migration." ], "offsets": [ [ 750, 925 ] ] } ]
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"normalized": [ { "db_name": "PubChem", "db_id": "1606" } ] }, { "id": "DS.d826.s1.e2", "type": "compound", "text": [ "peptide, a" ], "offsets": [ [ 468, 478 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "52944803" } ] }, { "id": "DS.d826.s1.e3", "type": "compound", "text": [ "AMD3100" ], "offsets": [ [ 509, 516 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65015" } ] }, { "id": "DS.d826.s2.e0", "type": "compound", "text": [ "DETA-NONOate" ], "offsets": [ [ 587, 599 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1606" } ] }, { "id": "DS.d826.s2.e1", "type": "protein", "text": [ "SDF1" ], "offsets": [ [ 642, 646 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62657" }, { "db_name": "UniProt", "db_id": "P48061" } ] }, { "id": "DS.d826.s2.e2", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 651, 655 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d826.s2.e3", "type": "protein", "text": [ "CXCR4" ], "offsets": [ [ 696, 701 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62747" }, { "db_name": "UniProt", "db_id": "P25930" }, { "db_name": "UniProt", "db_id": "P56491" }, { "db_name": "UniProt", "db_id": "P56498" }, { "db_name": "UniProt", "db_id": "P61072" }, { "db_name": "UniProt", "db_id": "P61073" }, { "db_name": "UniProt", "db_id": "P79394" }, { "db_name": "UniProt", "db_id": "Q28474" }, { "db_name": "UniProt", "db_id": "Q28553" }, { "db_name": "UniProt", "db_id": "Q3LSL6" }, { "db_name": "UniProt", "db_id": "Q764M9" }, { "db_name": "UniProt", "db_id": "Q7YS92" }, { "db_name": "UniProt", "db_id": "Q8HZU0" }, { "db_name": "UniProt", "db_id": "Q8HZU1" }, { "db_name": "UniProt", "db_id": "Q9TSQ8" } ] }, { "id": "DS.d826.s2.e4", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 706, 710 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] }, { "id": "DS.d826.s3.e0", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 800, 812 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d826.s3.e1", "type": "protein", "text": [ "SDF1" ], "offsets": [ [ 832, 836 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62657" }, { "db_name": "UniProt", "db_id": "P48061" } ] }, { "id": "DS.d826.s3.e2", "type": "protein", "text": [ "CXCR4" ], "offsets": [ [ 837, 842 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62747" }, { "db_name": "UniProt", "db_id": "P25930" }, { "db_name": "UniProt", "db_id": "P56491" }, { "db_name": "UniProt", "db_id": "P56498" }, { "db_name": "UniProt", "db_id": "P61072" }, { "db_name": "UniProt", "db_id": "P61073" }, { "db_name": "UniProt", "db_id": "P79394" }, { "db_name": "UniProt", "db_id": "Q28474" }, { "db_name": "UniProt", "db_id": "Q28553" }, { "db_name": "UniProt", "db_id": "Q3LSL6" }, { "db_name": "UniProt", "db_id": "Q764M9" }, { "db_name": "UniProt", "db_id": "Q7YS92" }, { "db_name": "UniProt", "db_id": "Q8HZU0" }, { "db_name": "UniProt", "db_id": "Q8HZU1" }, { "db_name": "UniProt", "db_id": "Q9TSQ8" } ] }, { "id": "DS.d826.s3.e3", "type": "protein", "text": [ "Ang1" ], "offsets": [ [ 847, 851 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21570" } ] }, { "id": "DS.d826.s3.e4", "type": "protein", "text": [ "Tie2" ], "offsets": [ [ 852, 856 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73791" }, { "db_name": "UniProt", "db_id": "Q02858" } ] } ]
[]
[]
[ { "id": "DS.d826.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e1", "arg2_id": "DS.d826.s0.e4", "normalized": [] }, { "id": "DS.d826.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e1", "arg2_id": "DS.d826.s0.e2", "normalized": [] }, { "id": "DS.d826.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e0", "arg2_id": "DS.d826.s0.e5", "normalized": [] }, { "id": "DS.d826.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e0", "arg2_id": "DS.d826.s0.e2", "normalized": [] }, { "id": "DS.d826.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e0", "arg2_id": "DS.d826.s0.e3", "normalized": [] }, { "id": "DS.d826.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e1", "arg2_id": "DS.d826.s0.e5", "normalized": [] }, { "id": "DS.d826.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e1", "arg2_id": "DS.d826.s0.e3", "normalized": [] }, { "id": "DS.d826.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s0.e0", "arg2_id": "DS.d826.s0.e4", "normalized": [] }, { "id": "DS.d826.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s1.e3", "arg2_id": "DS.d826.s1.e0", "normalized": [] }, { "id": "DS.d826.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s1.e1", "arg2_id": "DS.d826.s1.e0", "normalized": [] }, { "id": "DS.d826.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s1.e2", "arg2_id": "DS.d826.s1.e0", "normalized": [] }, { "id": "DS.d826.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s2.e0", "arg2_id": "DS.d826.s2.e3", "normalized": [] }, { "id": "DS.d826.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s2.e0", "arg2_id": "DS.d826.s2.e4", "normalized": [] }, { "id": "DS.d826.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s2.e0", "arg2_id": "DS.d826.s2.e1", "normalized": [] }, { "id": "DS.d826.s2.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s2.e0", "arg2_id": "DS.d826.s2.e2", "normalized": [] }, { "id": "DS.d826.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s3.e0", "arg2_id": "DS.d826.s3.e4", "normalized": [] }, { "id": "DS.d826.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s3.e0", "arg2_id": "DS.d826.s3.e3", "normalized": [] }, { "id": "DS.d826.s3.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s3.e0", "arg2_id": "DS.d826.s3.e1", "normalized": [] }, { "id": "DS.d826.s3.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d826.s3.e0", "arg2_id": "DS.d826.s3.e2", "normalized": [] } ]
DS.d827
18711750
[ { "id": "DS.d827.s0", "type": "", "text": [ "The MEK inhibitor PD98059 did not inhibit neurite outgrowth, and Y-27632 and staurosporine did not induce ERK phosphorylation, suggesting that the inhibitory effect of ODQ on neurite outgrowth is independent of the ERK signaling pathway." ], "offsets": [ [ 0, 237 ] ] } ]
[ { "id": "DS.d827.s0.e0", "type": "compound", "text": [ "PD98059" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d827.s0.e1", "type": "compound", "text": [ "staurosporine" ], "offsets": [ [ 77, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5279" }, { "db_name": "PubChem", "db_id": "44259" }, { "db_name": "PubChem", "db_id": "451705" }, { "db_name": "PubChem", "db_id": "5311103" }, { "db_name": "PubChem", "db_id": "5459111" }, { "db_name": "PubChem", "db_id": "6419748" }, { "db_name": "PubChem", "db_id": "6711321" }, { "db_name": "PubChem", "db_id": "9956178" }, { "db_name": "PubChem", "db_id": "44299148" } ] }, { "id": "DS.d827.s0.e2", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 106, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d827.s0.e3", "type": "compound", "text": [ "ODQ" ], "offsets": [ [ 168, 171 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1456" } ] }, { "id": "DS.d827.s0.e4", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 215, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]
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