bigbio/gad · Datasets at Hugging Face

id stringlengths 1 4	document_id stringlengths 1 4	text stringlengths 42 538	labels list
4200	4200	These findings confirm that @GENE$ variants influence colorectal @DISEASE$ independent of aspirin intake and suggest that they may have clinical value in secondary prevention programs for patients diagnosed with colorectal adenoma.	[ "0" ]
4201	4201	These data support the hypothesis that the @DISEASE$ observed in the blood vessels of smokers is related to reduced NO bioactivity but indicate that @GENE$ genotype does not influence significantly the level of plasma NO(x) or the risk of IHD in this population sample of middle-aged British men.	[ "0" ]
4202	4202	Our findings argue against an important predisposing effect of the MC1R and @GENE$ genes for @DISEASE$.	[ "1" ]
4203	4203	The incidence of @DISEASE$ in the @GENE$ domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival.	[ "0" ]
4204	4204	Genetic variation in @GENE$ does not have a major effect on @DISEASE$ susceptibility in the UK population.	[ "1" ]
4205	4205	The authors believe that @GENE$ VV genotype is associated with the development of NTDs and @DISEASE$.	[ "0" ]
4206	4206	Our data indicate that @GENE$ gene polymorphism as opposed to the other ethnic groups does not appear to be relevant in @DISEASE$ susceptibility in Mexican patients and that the distribution of the different alleles depend on the frequency of HLA alleles associated with them.	[ "1" ]
4207	4207	SNP rs3744700 of CXCL16 gene is independently associated with the development of CAD in Chinese Han population, and GG homozygote which is associated with increased expression of @GENE$ may have a promoting effect on @DISEASE$.	[ "1" ]
4208	4208	The @GENE$ of MC1R variants on risk of @DISEASE$ was mediated largely through the action of three common alleles, Arg151Cys, Arg160Trp, and Asp294His, that have previously been associated with red hair, fair skin, and skin sensitivity to ultraviolet light.	[ "0" ]
4209	4209	@GENE$ genetic variations are associated with risk factors, severity, type and prognosis of @DISEASE$ and oxidative stress.	[ "1" ]
4210	4210	Our results replicate previous findings and implicate the @GENE$ -38C/T SNP in the regulation of @DISEASE$ in West Africans.	[ "0" ]
4211	4211	The distribution of @GENE$ exon 1 A(49)G genotype, phenotype and allele frequencies did not differ between patients with @DISEASE$ and healthy subjects.	[ "1" ]
4212	4212	This study suggests that the Asn allele in the SHBG gene may be related to a reduced risk of @DISEASE$ among postmenopausal women by increasing their blood @GENE$ levels.	[ "1" ]
4213	4213	Our findings show that the @GENE$/NPRA system significantly contributes to ventricular remodeling in human @DISEASE$.	[ "0" ]
4214	4214	These observations suggest that the 4G/5G polymorphism in @GENE$ may explain some of the increased risk and earlier mean age of onset of @DISEASE$ due to a positive family history.	[ "1" ]
4215	4215	These results suggest that the tested functional variation of @GENE$, IL-8, IL-1alpha, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of @DISEASE$ in the Spanish population.	[ "0" ]
4216	4216	Thus, neither HLA DMA nor @GENE$ was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same DMB allele distribution.	[ "1" ]
4217	4217	These data indicate that the effect of @GENE$ gene variation is attributable to the 5A/6A polymorphism and that individuals carrying the 6A/6A genotype may be predisposed to developing atherosclerotic @DISEASE$ with significant stenosis, whereas those carrying the 5A allele may be predisposed to developing unstable plaques.	[ "0" ]
4218	4218	@GENE$ gene may be involved in the development of @DISEASE$ by moderating the impact of depressogenic social influences.	[ "0" ]
4219	4219	@GENE$ variation, although strongly associated with A1C, does not seem to be involved in @DISEASE$ glucose control.	[ "0" ]
4220	4220	the rs11200638 variant in the @GENE$ gene is strongly associated with @DISEASE$ in the Japanese population.	[ "1" ]
4221	4221	Our findings suggest that the @GENE$ 2677G>T and 3435C>T polymorphisms can be used for predicting treatment response to etoposide-cisplatin chemotherapy in @DISEASE$ patients.	[ "0" ]
4222	4222	The @GENE$ N34S mutation appears not to predispose Hispanic or non-Hispanic white people from the USA to the development of @DISEASE$.	[ "1" ]
4223	4223	In conclusion, the frequency of the 112/121 at-risk haplotype of @GENE$ is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and @DISEASE$, insulin resistance, or impaired insulin secretion.	[ "0" ]
4224	4224	We found that patients with the @GENE$ GA/AA genotype were more likely to have advanced @DISEASE$ scores	[ "0" ]
4225	4225	The polymorphisms of @GENE$ and IL-6 -174G/C appear to be associated with @DISEASE$, and the polymorphisms of IL-1 +3953 and IL-10 promoter gene are not associated with PBC in a Chinese population.	[ "0" ]
4226	4226	In contrast to traditional coronary risk factors, the @GENE$ M/L @DISEASE$ can be considered predictive of protection against CAD.	[ "0" ]
4227	4227	It is unlikely that @GENE$ c.1-34T>C has a role in @DISEASE$ etiology, overall or in combination with established non-genetic breast cancer risk factors.	[ "1" ]
4228	4228	Differences in physiological levels of @GENE$ expression did not modify HIV-1 @DISEASE$ in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.	[ "0" ]
4229	4229	In this sample, @GENE$ AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for @DISEASE$.	[ "1" ]
4230	4230	Our findings indicate that the @GENE$ @DISEASE$ polymorphism may not be associated with risk of lung cancer in the Chinese population.	[ "0" ]
4231	4231	The results suggest that the @GENE$ gene may not be involved in the etiology and @DISEASE$ of schizophrenia in the Chinese population.	[ "0" ]
4232	4232	These results suggest that unlike for other cancer types, the @GENE$ Ser326Cys polymorphism is not a major genetic risk factor for @DISEASE$.	[ "1" ]
4233	4233	Our findings suggest that the @GENE$-repeat polymorphism in the promoter region of the NEP gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset @DISEASE$.	[ "0" ]
4234	4234	The findings of this large study strongly support the notion that @GENE$ mutations characterize a subgroup of bladder cancers with good prognosis; patients with @DISEASE$ TaG1 tumors have a higher risk of recurrence; and the F386L variant is selectively associated with low-grade tumors.	[ "0" ]
4235	4235	These studies support that @GENE$ mutations are not a common cause of CAD in white people and argue strongly against a role for the MEF2A 21-bp @DISEASE$ in autosomal dominant CAD.	[ "0" ]
4236	4236	These results suggest that @GENE$ variants may act through insulin secretion to increase the risk of @DISEASE$.	[ "1" ]
4237	4237	The data obtained in the present study strengthen the evidence of an association of the @GENE$ T8590C polymorphism with @DISEASE$ pressure levels and hypertension prevalence.	[ "0" ]
4238	4238	We observed that @GENE$ G395A polymorphism was associated with @DISEASE$ pressure and KLOTHO C1818T polymorphism was associated with glucose metabolism in Korean women.	[ "0" ]
4239	4239	Our results provide no evidence for an association between @DISEASE$ risk and @GENE$ T/C polymorphism.	[ "1" ]
4240	4240	These results demonstrate the association of a new polymorphism of @GENE$ (I232T) with susceptibility to @DISEASE$ in the Japanese.	[ "1" ]
4241	4241	These data suggest that the gene for the proinflammatory chemokine @GENE$ is involved in susceptibility to @DISEASE$ during upper urinary tract infection in children with or without vesicoureteral reflux.	[ "0" ]
4242	4242	In conclusion, the hypofibrinolytic genotypes 4G/4G and A/A at positions -675 and -844 of the PAI-1 gene are associated with the occurrence of mild @DISEASE$ independently of thrombophilic mutations of the factor V, @GENE$, and MTHFR genes.	[ "0" ]
4243	4243	Results from this first study of MPO genotypes and breast cancer risk indicate that @GENE$ variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of @DISEASE$ risk.	[ "1" ]
4244	4244	Our data suggest that @GENE$ @DISEASE$ is a typical feature of certain subtypes of ovarian carcinoma.	[ "0" ]
4245	4245	This @DISEASE$ is consistent with the suggestion that the K variant of @GENE$ has an important role in disease progression in AD, and this may have implications for treatment.	[ "0" ]
4246	4246	Cerebellar @DISEASE$ consistent with the @GENE$ may be relatively common in patients with juvenile NPHP without classic symptoms of JS.	[ "0" ]
4247	4247	These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of @DISEASE$ in BRCA1 or @GENE$ mutation carriers.	[ "1" ]
4248	4248	These results suggest that a Trp64Arg @DISEASE$ in the @GENE$-adrenergic receptor gene is not associated with hypertension in Japanese NIDDM patients without nephropathy.	[ "0" ]
4249	4249	Our study suggests a potential role of the @GENE$ polymorphisms and their haplotypes in susceptibility to @DISEASE$ and disease severity.	[ "0" ]
4250	4250	Our data suggest that the association between the @GENE$ -238 polymorphism and @DISEASE$ could play a major role in disease susceptibility.	[ "0" ]
4251	4251	The results support a possible role of the @GENE$ gene in @DISEASE$.	[ "1" ]
4252	4252	Polymorphisms in the oxidative stress-related genes (@GENE$, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for @DISEASE$.	[ "1" ]
4253	4253	All these results suggest that the Q(296) @DISEASE$ in @GENE$ gene was closely related to CHD, and the identification of new mutations in the CETP gene will afford the opportunity to investigate the relationship between CETP gene and CHD.	[ "0" ]
4254	4254	Our findings suggest that the @GENE$/@DISEASE$ genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial damage in patients with untreated hypertension.	[ "0" ]
4255	4255	The @GENE$ and CDSN genes are important @DISEASE$ susceptibility genes in Chinese patients with psoriasis vulgaris.	[ "0" ]
4256	4256	This suggests that both polymorphisms in the @GENE$ gene may be associated with lipid and lipoprotein @DISEASE$ in CHD in the Chinese.	[ "0" ]
4257	4257	This study suggests that common variation at the @GENE$ gene (and not just rare loss-of-function mutations) is associated with @DISEASE$ in girls and young women.	[ "0" ]
4258	4258	The SLC6A14 gene is an interesting novel candidate for @DISEASE$ because it encodes an @GENE$, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.	[ "0" ]
4259	4259	Serine at position 986 of @GENE$ may be an independent genetic predictor of angiographic @DISEASE$, previous MI, and cardiovascular mortality.	[ "0" ]
4260	4260	A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the @GENE$ gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced @DISEASE$ and edema in patients with type 2 diabetes.	[ "0" ]

4200

These findings confirm that @GENE$ variants influence colorectal @DISEASE$ independent of aspirin intake and suggest that they may have clinical value in secondary prevention programs for patients diagnosed with colorectal adenoma.

[ "0" ]

4201

These data support the hypothesis that the @DISEASE$ observed in the blood vessels of smokers is related to reduced NO bioactivity but indicate that @GENE$ genotype does not influence significantly the level of plasma NO(x) or the risk of IHD in this population sample of middle-aged British men.

[ "0" ]

4202

Our findings argue against an important predisposing effect of the MC1R and @GENE$ genes for @DISEASE$.

[ "1" ]

4203

The incidence of @DISEASE$ in the @GENE$ domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival.

[ "0" ]

4204

Genetic variation in @GENE$ does not have a major effect on @DISEASE$ susceptibility in the UK population.

[ "1" ]

4205

The authors believe that @GENE$ VV genotype is associated with the development of NTDs and @DISEASE$.

[ "0" ]

4206

Our data indicate that @GENE$ gene polymorphism as opposed to the other ethnic groups does not appear to be relevant in @DISEASE$ susceptibility in Mexican patients and that the distribution of the different alleles depend on the frequency of HLA alleles associated with them.

[ "1" ]

4207

SNP rs3744700 of CXCL16 gene is independently associated with the development of CAD in Chinese Han population, and GG homozygote which is associated with increased expression of @GENE$ may have a promoting effect on @DISEASE$.

[ "1" ]

4208

The @GENE$ of MC1R variants on risk of @DISEASE$ was mediated largely through the action of three common alleles, Arg151Cys, Arg160Trp, and Asp294His, that have previously been associated with red hair, fair skin, and skin sensitivity to ultraviolet light.

[ "0" ]

4209

@GENE$ genetic variations are associated with risk factors, severity, type and prognosis of @DISEASE$ and oxidative stress.

[ "1" ]

4210

Our results replicate previous findings and implicate the @GENE$ -38C/T SNP in the regulation of @DISEASE$ in West Africans.

[ "0" ]

4211

The distribution of @GENE$ exon 1 A(49)G genotype, phenotype and allele frequencies did not differ between patients with @DISEASE$ and healthy subjects.

[ "1" ]

4212

This study suggests that the Asn allele in the SHBG gene may be related to a reduced risk of @DISEASE$ among postmenopausal women by increasing their blood @GENE$ levels.

[ "1" ]

4213

Our findings show that the @GENE$/NPRA system significantly contributes to ventricular remodeling in human @DISEASE$.

[ "0" ]

4214

These observations suggest that the 4G/5G polymorphism in @GENE$ may explain some of the increased risk and earlier mean age of onset of @DISEASE$ due to a positive family history.

[ "1" ]

4215

These results suggest that the tested functional variation of @GENE$, IL-8, IL-1alpha, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of @DISEASE$ in the Spanish population.

[ "0" ]

4216

Thus, neither HLA DMA nor @GENE$ was associated with @DISEASE$ in this population, and not all shared-epitope-bearing haplotypes had the same DMB allele distribution.

[ "1" ]

4217

These data indicate that the effect of @GENE$ gene variation is attributable to the 5A/6A polymorphism and that individuals carrying the 6A/6A genotype may be predisposed to developing atherosclerotic @DISEASE$ with significant stenosis, whereas those carrying the 5A allele may be predisposed to developing unstable plaques.

[ "0" ]

4218

@GENE$ gene may be involved in the development of @DISEASE$ by moderating the impact of depressogenic social influences.

[ "0" ]

4219

@GENE$ variation, although strongly associated with A1C, does not seem to be involved in @DISEASE$ glucose control.

[ "0" ]

4220

the rs11200638 variant in the @GENE$ gene is strongly associated with @DISEASE$ in the Japanese population.

[ "1" ]

4221

Our findings suggest that the @GENE$ 2677G>T and 3435C>T polymorphisms can be used for predicting treatment response to etoposide-cisplatin chemotherapy in @DISEASE$ patients.

[ "0" ]

4222

The @GENE$ N34S mutation appears not to predispose Hispanic or non-Hispanic white people from the USA to the development of @DISEASE$.

[ "1" ]

4223

In conclusion, the frequency of the 112/121 at-risk haplotype of @GENE$ is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and @DISEASE$, insulin resistance, or impaired insulin secretion.

[ "0" ]

4224

We found that patients with the @GENE$ GA/AA genotype were more likely to have advanced @DISEASE$ scores

[ "0" ]

4225

The polymorphisms of @GENE$ and IL-6 -174G/C appear to be associated with @DISEASE$, and the polymorphisms of IL-1 +3953 and IL-10 promoter gene are not associated with PBC in a Chinese population.

[ "0" ]

4226

In contrast to traditional coronary risk factors, the @GENE$ M/L @DISEASE$ can be considered predictive of protection against CAD.

[ "0" ]

4227

It is unlikely that @GENE$ c.1-34T>C has a role in @DISEASE$ etiology, overall or in combination with established non-genetic breast cancer risk factors.

[ "1" ]

4228

Differences in physiological levels of @GENE$ expression did not modify HIV-1 @DISEASE$ in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.

[ "0" ]

4229

In this sample, @GENE$ AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for @DISEASE$.

[ "1" ]

4230

Our findings indicate that the @GENE$ @DISEASE$ polymorphism may not be associated with risk of lung cancer in the Chinese population.

[ "0" ]

4231

The results suggest that the @GENE$ gene may not be involved in the etiology and @DISEASE$ of schizophrenia in the Chinese population.

[ "0" ]

4232

These results suggest that unlike for other cancer types, the @GENE$ Ser326Cys polymorphism is not a major genetic risk factor for @DISEASE$.

[ "1" ]

4233

Our findings suggest that the @GENE$-repeat polymorphism in the promoter region of the NEP gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset @DISEASE$.

[ "0" ]

4234

The findings of this large study strongly support the notion that @GENE$ mutations characterize a subgroup of bladder cancers with good prognosis; patients with @DISEASE$ TaG1 tumors have a higher risk of recurrence; and the F386L variant is selectively associated with low-grade tumors.

[ "0" ]

4235

These studies support that @GENE$ mutations are not a common cause of CAD in white people and argue strongly against a role for the MEF2A 21-bp @DISEASE$ in autosomal dominant CAD.

[ "0" ]

4236

These results suggest that @GENE$ variants may act through insulin secretion to increase the risk of @DISEASE$.

[ "1" ]

4237

The data obtained in the present study strengthen the evidence of an association of the @GENE$ T8590C polymorphism with @DISEASE$ pressure levels and hypertension prevalence.

[ "0" ]

4238

We observed that @GENE$ G395A polymorphism was associated with @DISEASE$ pressure and KLOTHO C1818T polymorphism was associated with glucose metabolism in Korean women.

[ "0" ]

4239

Our results provide no evidence for an association between @DISEASE$ risk and @GENE$ T/C polymorphism.

[ "1" ]

4240

These results demonstrate the association of a new polymorphism of @GENE$ (I232T) with susceptibility to @DISEASE$ in the Japanese.

[ "1" ]

4241

These data suggest that the gene for the proinflammatory chemokine @GENE$ is involved in susceptibility to @DISEASE$ during upper urinary tract infection in children with or without vesicoureteral reflux.

[ "0" ]

4242

In conclusion, the hypofibrinolytic genotypes 4G/4G and A/A at positions -675 and -844 of the PAI-1 gene are associated with the occurrence of mild @DISEASE$ independently of thrombophilic mutations of the factor V, @GENE$, and MTHFR genes.

[ "0" ]

4243

Results from this first study of MPO genotypes and breast cancer risk indicate that @GENE$ variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of @DISEASE$ risk.

[ "1" ]

4244

Our data suggest that @GENE$ @DISEASE$ is a typical feature of certain subtypes of ovarian carcinoma.

[ "0" ]

4245

This @DISEASE$ is consistent with the suggestion that the K variant of @GENE$ has an important role in disease progression in AD, and this may have implications for treatment.

[ "0" ]

4246

Cerebellar @DISEASE$ consistent with the @GENE$ may be relatively common in patients with juvenile NPHP without classic symptoms of JS.

[ "0" ]

4247

These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of @DISEASE$ in BRCA1 or @GENE$ mutation carriers.

[ "1" ]

4248

These results suggest that a Trp64Arg @DISEASE$ in the @GENE$-adrenergic receptor gene is not associated with hypertension in Japanese NIDDM patients without nephropathy.

[ "0" ]

4249

Our study suggests a potential role of the @GENE$ polymorphisms and their haplotypes in susceptibility to @DISEASE$ and disease severity.

[ "0" ]

4250

Our data suggest that the association between the @GENE$ -238 polymorphism and @DISEASE$ could play a major role in disease susceptibility.

[ "0" ]

4251

The results support a possible role of the @GENE$ gene in @DISEASE$.

[ "1" ]

4252

Polymorphisms in the oxidative stress-related genes (@GENE$, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for @DISEASE$.

[ "1" ]

4253

All these results suggest that the Q(296) @DISEASE$ in @GENE$ gene was closely related to CHD, and the identification of new mutations in the CETP gene will afford the opportunity to investigate the relationship between CETP gene and CHD.

[ "0" ]

4254

Our findings suggest that the @GENE$/@DISEASE$ genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial damage in patients with untreated hypertension.

[ "0" ]

4255

The @GENE$ and CDSN genes are important @DISEASE$ susceptibility genes in Chinese patients with psoriasis vulgaris.

[ "0" ]

4256

This suggests that both polymorphisms in the @GENE$ gene may be associated with lipid and lipoprotein @DISEASE$ in CHD in the Chinese.

[ "0" ]

4257

This study suggests that common variation at the @GENE$ gene (and not just rare loss-of-function mutations) is associated with @DISEASE$ in girls and young women.

[ "0" ]

4258

The SLC6A14 gene is an interesting novel candidate for @DISEASE$ because it encodes an @GENE$, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.

[ "0" ]

4259

Serine at position 986 of @GENE$ may be an independent genetic predictor of angiographic @DISEASE$, previous MI, and cardiovascular mortality.

[ "0" ]

4260

A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the @GENE$ gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced @DISEASE$ and edema in patients with type 2 diabetes.

[ "0" ]