0
dict | 1
float64 0
0
| 2
dict |
|---|---|---|
{
"aliases": null,
"definition": "The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney.",
"id": "RenalInterstitialCalciumOxalate",
"label": "Renal interstitial calcium oxalate",
"logical_definition": null,
"original_id": "HP:0032587",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial calcium oxalate The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits.",
"id": "RenalInterstitialCalciumPhosphateDeposits",
"label": "Renal interstitial calcium phosphate deposits",
"logical_definition": null,
"original_id": "HP:0032949",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialDeposits"
}
]
}
| 0 |
{
"document": "Renal interstitial calcium phosphate deposits The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits. [{'predicate': 'subClassOf', 'target': 'RenalInterstitialDeposits'}]"
}
|
{
"aliases": null,
"definition": "Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney.",
"id": "RenalInterstitialDeposits",
"label": "Renal interstitial deposits",
"logical_definition": null,
"original_id": "HP:0032644",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial deposits Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density.",
"id": "RenalInterstitialEdema",
"label": "Renal interstitial edema",
"logical_definition": null,
"original_id": "HP:0032637",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial edema Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Increased numbers of eosinophils in the interstitial tissues of the kidney.",
"id": "RenalInterstitialEosinophilInfiltration",
"label": "Renal interstitial eosinophil infiltration",
"logical_definition": null,
"original_id": "HP:0032585",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial eosinophil infiltration Increased numbers of eosinophils in the interstitial tissues of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic.",
"id": "RenalInterstitialFibrosis",
"label": "Renal interstitial fibrosis",
"logical_definition": null,
"original_id": "HP:0032948",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial fibrosis The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles.",
"id": "RenalInterstitialFoamCells",
"label": "Renal interstitial foam cells",
"logical_definition": null,
"original_id": "HP:0032582",
"relationships": [
{
"predicate": "subClassOf",
"target": "FoamCells"
},
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial foam cells Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles. [{'predicate': 'subClassOf', 'target': 'FoamCells'}, {'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC).",
"id": "RenalInterstitialGlobotriaosylceramideInclusions",
"label": "Renal interstitial globotriaosylceramide inclusions",
"logical_definition": null,
"original_id": "HP:0033064",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial globotriaosylceramide inclusions Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC). [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present.",
"id": "RenalInterstitialGranulomas",
"label": "Renal interstitial granulomas",
"logical_definition": null,
"original_id": "HP:0032641",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial granulomas Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core.",
"id": "RenalInterstitialHemorrhage",
"label": "Renal interstitial hemorrhage",
"logical_definition": null,
"original_id": "HP:0032617",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial hemorrhage A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney.",
"id": "RenalInterstitialHemosiderin",
"label": "Renal interstitial hemosiderin",
"logical_definition": null,
"original_id": "HP:0032591",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialDeposits"
}
]
}
| 0 |
{
"document": "Renal interstitial hemosiderin Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney. [{'predicate': 'subClassOf', 'target': 'RenalInterstitialDeposits'}]"
}
|
{
"aliases": null,
"definition": "An increased number of IgG4+ plasma cells in the interstitial space of the kidney.",
"id": "RenalInterstitialIgG4_plasmaCellInfiltration",
"label": "Renal interstitial IgG4+ plasma cell infiltration",
"logical_definition": null,
"original_id": "HP:0033069",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial IgG4+ plasma cell infiltration An increased number of IgG4+ plasma cells in the interstitial space of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining).",
"id": "RenalInterstitialImmunoglobulinDeposits",
"label": "Renal interstitial immunoglobulin deposits",
"logical_definition": null,
"original_id": "HP:0032616",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialDeposits"
}
]
}
| 0 |
{
"document": "Renal interstitial immunoglobulin deposits Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining). [{'predicate': 'subClassOf', 'target': 'RenalInterstitialDeposits'}]"
}
|
{
"aliases": null,
"definition": "Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells.",
"id": "RenalInterstitialInflammation",
"label": "Renal interstitial inflammation",
"logical_definition": null,
"original_id": "HP:0032945",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial inflammation Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei).",
"id": "RenalInterstitialMononuclearCellInfiltration",
"label": "Renal interstitial mononuclear cell infiltration",
"logical_definition": null,
"original_id": "HP:0032645",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial mononuclear cell infiltration Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei). [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation.",
"id": "RenalInterstitialNecrotizingGranulomas",
"label": "Renal interstitial necrotizing granulomas",
"logical_definition": null,
"original_id": "HP:0032642",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialGranulomas"
}
]
}
| 0 |
{
"document": "Renal interstitial necrotizing granulomas An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation. [{'predicate': 'subClassOf', 'target': 'RenalInterstitialGranulomas'}]"
}
|
{
"aliases": null,
"definition": "Increased numbers of neutrophils in the interstitial tissues of the kidney.",
"id": "RenalInterstitialNeutrophilInfiltration",
"label": "Renal interstitial neutrophil infiltration",
"logical_definition": null,
"original_id": "HP:0032584",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial neutrophil infiltration Increased numbers of neutrophils in the interstitial tissues of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis.",
"id": "RenalInterstitialNonNecrotizingGranulomas",
"label": "Renal interstitial non-necrotizing granulomas",
"logical_definition": null,
"original_id": "HP:0032643",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialGranulomas"
}
]
}
| 0 |
{
"document": "Renal interstitial non-necrotizing granulomas Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis. [{'predicate': 'subClassOf', 'target': 'RenalInterstitialGranulomas'}]"
}
|
{
"aliases": null,
"definition": "A pericyte cell located in the kidney interstitium.",
"id": "RenalInterstitialPericyte",
"label": "renal interstitial pericyte",
"logical_definition": null,
"original_id": "CL:1001318",
"relationships": [
{
"predicate": "subClassOf",
"target": "Pericyte"
}
]
}
| 0 |
{
"document": "renal interstitial pericyte A pericyte cell located in the kidney interstitium. [{'predicate': 'subClassOf', 'target': 'Pericyte'}]"
}
|
{
"aliases": null,
"definition": "Increased numbers of plasma cells in the interstitial tissues of the kidney.",
"id": "RenalInterstitialPlasmaCellInfiltration",
"label": "Renal interstitial plasma cell infiltration",
"logical_definition": null,
"original_id": "HP:0032586",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial plasma cell infiltration Increased numbers of plasma cells in the interstitial tissues of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells.",
"id": "RenalInterstitialXanthogranulomatousInflammation",
"label": "Renal interstitial xanthogranulomatous inflammation",
"logical_definition": null,
"original_id": "HP:0032646",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalInsterstitialMorphology"
}
]
}
| 0 |
{
"document": "Renal interstitial xanthogranulomatous inflammation Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalInsterstitialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural.",
"id": "RenalIntimalMedialArteriolitis",
"label": "Renal intimal/medial arteriolitis",
"logical_definition": null,
"original_id": "HP:0033906",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalArterioleIntimaMediaMorphology"
}
]
}
| 0 |
{
"document": "Renal intimal/medial arteriolitis Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalArterioleIntimaMediaMorphology'}]"
}
|
{
"aliases": null,
"definition": "Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast.",
"id": "RenalIntratubularCasts",
"label": "Renal intratubular casts",
"logical_definition": null,
"original_id": "HP:0032623",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renal intratubular casts Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": null,
"id": "RenalIntratubularCrystals",
"label": "Renal intratubular crystals",
"logical_definition": null,
"original_id": "HP:0032628",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renal intratubular crystals None [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": "Increased number and size of the juxtaglomerular cells.",
"id": "RenalJuxtaglomerularCellHypertrophyHyperplasia",
"label": "Renal juxtaglomerular cell hypertrophy/hyperplasia",
"logical_definition": null,
"original_id": "HP:0000111",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalGlomerulusMorphology"
}
]
}
| 0 |
{
"document": "Renal juxtaglomerular cell hypertrophy/hyperplasia Increased number and size of the juxtaglomerular cells. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalGlomerulusMorphology'}]"
}
|
{
"aliases": null,
"definition": "The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP].",
"id": "RenalLobe",
"label": "renal lobe",
"logical_definition": null,
"original_id": "UBERON:0009913",
"relationships": [
{
"predicate": "ContributesToMorphologyOf",
"target": "Kidney"
}
]
}
| 0 |
{
"document": "renal lobe The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP]. [{'predicate': 'ContributesToMorphologyOf', 'target': 'Kidney'}]"
}
|
{
"aliases": null,
"definition": "The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys.",
"id": "RenalLobule",
"label": "renal lobule",
"logical_definition": null,
"original_id": "UBERON:0009914",
"relationships": [
{
"predicate": "PartOf",
"target": "RenalLobe"
},
{
"predicate": "HasPart",
"target": "Nephron"
},
{
"predicate": "HasPart",
"target": "MedullaryRay"
},
{
"predicate": "ContributesToMorphologyOf",
"target": "Kidney"
}
]
}
| 0 |
{
"document": "renal lobule The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys. [{'predicate': 'PartOf', 'target': 'RenalLobe'}, {'predicate': 'HasPart', 'target': 'Nephron'}, {'predicate': 'HasPart', 'target': 'MedullaryRay'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'Kidney'}]"
}
|
{
"aliases": null,
"definition": "A lymph node that is located in a kidney [Automatically generated definition].",
"id": "RenalLymphNode",
"label": "renal lymph node",
"logical_definition": null,
"original_id": "UBERON:0003425",
"relationships": null
}
| 0 |
{
"document": "renal lymph node A lymph node that is located in a kidney [Automatically generated definition]. None"
}
|
{
"aliases": null,
"definition": "Infiltration of the renal tubular epithelium by lymphocytes.",
"id": "RenalLymphocyticTubulitis",
"label": "Renal lymphocytic tubulitis",
"logical_definition": null,
"original_id": "HP:0032589",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renal lymphocytic tubulitis Infiltration of the renal tubular epithelium by lymphocytes. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": "High urine magnesium in the presence of hypomagnesemia.",
"id": "RenalMagnesiumWasting",
"label": "Renal magnesium wasting",
"logical_definition": null,
"original_id": "HP:0005567",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalUrineMagnesiumConcentration"
}
]
}
| 0 |
{
"document": "Renal magnesium wasting High urine magnesium in the presence of hypomagnesemia. [{'predicate': 'subClassOf', 'target': 'AbnormalUrineMagnesiumConcentration'}]"
}
|
{
"aliases": null,
"definition": "An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney.",
"id": "RenalMalrotation",
"label": "Renal malrotation",
"logical_definition": null,
"original_id": "HP:0004712",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalMorphology"
}
]
}
| 0 |
{
"document": "Renal malrotation An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalMorphology'}]"
}
|
{
"aliases": null,
"definition": "The inner portion of the kidney consisting of the renal pyramids.",
"id": "RenalMedulla",
"label": "renal medulla",
"logical_definition": null,
"original_id": "UBERON:0000362",
"relationships": [
{
"predicate": "HasPart",
"target": "KidneyPyramid"
},
{
"predicate": "CapableOfPartOf",
"target": "RenalWaterAbsorption"
},
{
"predicate": "ContributesToMorphologyOf",
"target": "Kidney"
},
{
"predicate": "subClassOf",
"target": "MulticellularAnatomicalStructure"
}
]
}
| 0 |
{
"document": "renal medulla The inner portion of the kidney consisting of the renal pyramids. [{'predicate': 'HasPart', 'target': 'KidneyPyramid'}, {'predicate': 'CapableOfPartOf', 'target': 'RenalWaterAbsorption'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'Kidney'}, {'predicate': 'subClassOf', 'target': 'MulticellularAnatomicalStructure'}]"
}
|
{
"aliases": null,
"definition": "The portion of the collecting duct that resides in the renal medulla.",
"id": "RenalMedullaCollectingDuct",
"label": "renal medulla collecting duct",
"logical_definition": null,
"original_id": "UBERON:0005185",
"relationships": null
}
| 0 |
{
"document": "renal medulla collecting duct The portion of the collecting duct that resides in the renal medulla. None"
}
|
{
"aliases": null,
"definition": "Tissue surrounding the loop of Henle in the renal medulla.",
"id": "RenalMedullaInterstitium",
"label": "renal medulla interstitium",
"logical_definition": null,
"original_id": "UBERON:0005211",
"relationships": [
{
"predicate": "PartOf",
"target": "KidneyInterstitium"
},
{
"predicate": "CapableOfPartOf",
"target": "RenalWaterAbsorption"
}
]
}
| 0 |
{
"document": "renal medulla interstitium Tissue surrounding the loop of Henle in the renal medulla. [{'predicate': 'PartOf', 'target': 'KidneyInterstitium'}, {'predicate': 'CapableOfPartOf', 'target': 'RenalWaterAbsorption'}]"
}
|
{
"aliases": null,
"definition": "A fibroblast that is located in the renal medulla interstitium.",
"id": "RenalMedullaryFibroblast",
"label": "renal medullary fibroblast",
"logical_definition": null,
"original_id": "CL:4030022",
"relationships": null
}
| 0 |
{
"document": "renal medullary fibroblast A fibroblast that is located in the renal medulla interstitium. None"
}
|
{
"aliases": null,
"definition": "Increased echogenecity of the medullary region of the kidney.",
"id": "RenalMedullaryHyperechogenicity",
"label": "Renal medullary hyperechogenicity",
"logical_definition": null,
"original_id": "HP:0033131",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalEchogenicity"
}
]
}
| 0 |
{
"document": "Renal medullary hyperechogenicity Increased echogenecity of the medullary region of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalEchogenicity'}]"
}
|
{
"aliases": null,
"definition": "Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells.",
"id": "RenalMedullaryInterstitialInflammation",
"label": "Renal medullary interstitial inflammation",
"logical_definition": null,
"original_id": "HP:0032947",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalInterstitialInflammation"
}
]
}
| 0 |
{
"document": "Renal medullary interstitial inflammation Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells. [{'predicate': 'subClassOf', 'target': 'RenalInterstitialInflammation'}]"
}
|
{
"aliases": null,
"definition": "Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla.",
"id": "RenalMedullaryPyramidHypoplasia",
"label": "Renal medullary pyramid hypoplasia",
"logical_definition": null,
"original_id": "HP:0025362",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalityOfMedullaryPyramidMorphology"
}
]
}
| 0 |
{
"document": "Renal medullary pyramid hypoplasia Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfMedullaryPyramidMorphology'}]"
}
|
{
"aliases": null,
"definition": "Cell death (necrosis) affecting one or more parts of the kidney.",
"id": "RenalNecrosis",
"label": "Renal necrosis",
"logical_definition": null,
"original_id": "HP:0032618",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalMorphology"
}
]
}
| 0 |
{
"document": "Renal necrosis Cell death (necrosis) affecting one or more parts of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalMorphology'}]"
}
|
{
"aliases": null,
"definition": "The presence of a neoplasm of the kidney.",
"id": "RenalNeoplasm",
"label": "Renal neoplasm",
"logical_definition": null,
"original_id": "HP:0009726",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalityOfTheKidney"
},
{
"predicate": "subClassOf",
"target": "UrinaryTractNeoplasm"
}
]
}
| 0 |
{
"document": "Renal neoplasm The presence of a neoplasm of the kidney. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfTheKidney'}, {'predicate': 'subClassOf', 'target': 'UrinaryTractNeoplasm'}]"
}
|
{
"aliases": null,
"definition": "A neurofibroma (benign peripheral nerve sheath tumor) localized in the kidney.",
"id": "RenalNeurofibroma",
"label": "Renal neurofibroma",
"logical_definition": null,
"original_id": "HP:0034765",
"relationships": [
{
"predicate": "subClassOf",
"target": "NeurofibromaByAnatomicalLocation"
}
]
}
| 0 |
{
"document": "Renal neurofibroma A neurofibroma (benign peripheral nerve sheath tumor) localized in the kidney. [{'predicate': 'subClassOf', 'target': 'NeurofibromaByAnatomicalLocation'}]"
}
|
{
"aliases": null,
"definition": "Infiltration of the renal tubular epithelium by neutrophils.",
"id": "RenalNeutrophilicTubulitis",
"label": "Renal neutrophilic tubulitis",
"logical_definition": null,
"original_id": "HP:0032590",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renal neutrophilic tubulitis Infiltration of the renal tubular epithelium by neutrophils. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": "A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.",
"id": "RenalOncocytoma",
"label": "Renal oncocytoma",
"logical_definition": null,
"original_id": "HP:0011798",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalNeoplasm"
}
]
}
| 0 |
{
"document": "Renal oncocytoma A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. [{'predicate': 'subClassOf', 'target': 'RenalNeoplasm'}]"
}
|
{
"aliases": null,
"definition": "Tip of renal pyramid projecting into a minor calyx.",
"id": "RenalPapilla",
"label": "renal papilla",
"logical_definition": null,
"original_id": "UBERON:0001228",
"relationships": [
{
"predicate": "PartOf",
"target": "RenalPelvis"
},
{
"predicate": "PartOf",
"target": "InnerMedullaOfKidney"
},
{
"predicate": "ContributesToMorphologyOf",
"target": "RenalPelvis"
},
{
"predicate": "subClassOf",
"target": "OrganPart"
}
]
}
| 0 |
{
"document": "renal papilla Tip of renal pyramid projecting into a minor calyx. [{'predicate': 'PartOf', 'target': 'RenalPelvis'}, {'predicate': 'PartOf', 'target': 'InnerMedullaOfKidney'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'RenalPelvis'}, {'predicate': 'subClassOf', 'target': 'OrganPart'}]"
}
|
{
"aliases": null,
"definition": "Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei.",
"id": "RenalPapillaryNecrosis",
"label": "Renal papillary necrosis",
"logical_definition": null,
"original_id": "HP:0032632",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalNecrosis"
}
]
}
| 0 |
{
"document": "Renal papillary necrosis Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei. [{'predicate': 'subClassOf', 'target': 'RenalNecrosis'}]"
}
|
{
"aliases": null,
"definition": "The functional tissue of the kidney, consisting of the nephrons.",
"id": "RenalParenchyma",
"label": "renal parenchyma",
"logical_definition": null,
"original_id": "UBERON:0008987",
"relationships": [
{
"predicate": "PartOf",
"target": "Kidney"
},
{
"predicate": "subClassOf",
"target": "Parenchyma"
}
]
}
| 0 |
{
"document": "renal parenchyma The functional tissue of the kidney, consisting of the nephrons. [{'predicate': 'PartOf', 'target': 'Kidney'}, {'predicate': 'subClassOf', 'target': 'Parenchyma'}]"
}
|
{
"aliases": null,
"definition": "The presence of a carcinoma in the renal pelvis.",
"id": "RenalPelvicCarcinoma",
"label": "Renal pelvic carcinoma",
"logical_definition": null,
"original_id": "HP:0006762",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalNeoplasm"
}
]
}
| 0 |
{
"document": "Renal pelvic carcinoma The presence of a carcinoma in the renal pelvis. [{'predicate': 'subClassOf', 'target': 'RenalNeoplasm'}]"
}
|
{
"aliases": null,
"definition": "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP].",
"id": "RenalPelvis",
"label": "renal pelvis",
"logical_definition": null,
"original_id": "UBERON:0001224",
"relationships": [
{
"predicate": "PartOf",
"target": "Kidney"
},
{
"predicate": "PartOf",
"target": "RenalPelvisUreter"
},
{
"predicate": "ContinuousWith",
"target": "Ureter"
},
{
"predicate": "ContributesToMorphologyOf",
"target": "Ureter"
},
{
"predicate": "ChannelFor",
"target": "Urine"
},
{
"predicate": "ChannelsFrom",
"target": "Kidney"
},
{
"predicate": "ChannelsInto",
"target": "Ureter"
},
{
"predicate": "subClassOf",
"target": "OrganPart"
}
]
}
| 0 |
{
"document": "renal pelvis A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]. [{'predicate': 'PartOf', 'target': 'Kidney'}, {'predicate': 'PartOf', 'target': 'RenalPelvisUreter'}, {'predicate': 'ContinuousWith', 'target': 'Ureter'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'Ureter'}, {'predicate': 'ChannelFor', 'target': 'Urine'}, {'predicate': 'ChannelsFrom', 'target': 'Kidney'}, {'predicate': 'ChannelsInto', 'target': 'Ureter'}, {'predicate': 'subClassOf', 'target': 'OrganPart'}]"
}
|
{
"aliases": null,
"definition": "The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra.",
"id": "RenalPelvisUreter",
"label": "renal pelvis/ureter",
"logical_definition": null,
"original_id": "UBERON:0036295",
"relationships": [
{
"predicate": "PartOf",
"target": "UpperUrinaryTract"
},
{
"predicate": "subClassOf",
"target": "AnatomicalCluster"
}
]
}
| 0 |
{
"document": "renal pelvis/ureter The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra. [{'predicate': 'PartOf', 'target': 'UpperUrinaryTract'}, {'predicate': 'subClassOf', 'target': 'AnatomicalCluster'}]"
}
|
{
"aliases": null,
"definition": "High urine phosphate in the presence of hypophosphatemia.",
"id": "RenalPhosphateWasting",
"label": "Renal phosphate wasting",
"logical_definition": null,
"original_id": "HP:0000117",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalUrinePhosphateConcentration"
}
]
}
| 0 |
{
"document": "Renal phosphate wasting High urine phosphate in the presence of hypophosphatemia. [{'predicate': 'subClassOf', 'target': 'AbnormalUrinePhosphateConcentration'}]"
}
|
{
"aliases": null,
"definition": "High urine potassium in the presence of hypokalemia.",
"id": "RenalPotassiumWasting",
"label": "Renal potassium wasting",
"logical_definition": null,
"original_id": "HP:0000128",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalUrinePotassiumConcentration"
}
]
}
| 0 |
{
"document": "Renal potassium wasting High urine potassium in the presence of hypokalemia. [{'predicate': 'subClassOf', 'target': 'AbnormalUrinePotassiumConcentration'}]"
}
|
{
"aliases": null,
"definition": "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.",
"id": "RenalPrincipalCell",
"label": "renal principal cell",
"logical_definition": null,
"original_id": "CL:0005009",
"relationships": [
{
"predicate": "subClassOf",
"target": "ColumnarCuboidalEpithelialCell"
},
{
"predicate": "subClassOf",
"target": "KidneyEpithelialCell"
}
]
}
| 0 |
{
"document": "renal principal cell A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system. [{'predicate': 'subClassOf', 'target': 'ColumnarCuboidalEpithelialCell'}, {'predicate': 'subClassOf', 'target': 'KidneyEpithelialCell'}]"
}
|
{
"aliases": null,
"definition": "A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s).",
"id": "RenalSaltWasting",
"label": "Renal salt wasting",
"logical_definition": null,
"original_id": "HP:0000127",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalUrinaryElectrolyteConcentration"
}
]
}
| 0 |
{
"document": "Renal salt wasting A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s). [{'predicate': 'subClassOf', 'target': 'AbnormalUrinaryElectrolyteConcentration'}]"
}
|
{
"aliases": null,
"definition": "A sarcoma of the kidney.",
"id": "RenalSarcoma",
"label": "Renal sarcoma",
"logical_definition": null,
"original_id": "HP:0008663",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalNeoplasm"
},
{
"predicate": "subClassOf",
"target": "Sarcoma"
}
]
}
| 0 |
{
"document": "Renal sarcoma A sarcoma of the kidney. [{'predicate': 'subClassOf', 'target': 'RenalNeoplasm'}, {'predicate': 'subClassOf', 'target': 'Sarcoma'}]"
}
|
{
"aliases": null,
"definition": "An abnormally increased sodium concentration in the urine in the presence of hyponatremia.",
"id": "RenalSodiumWasting",
"label": "Renal sodium wasting",
"logical_definition": null,
"original_id": "HP:0012606",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalUrineSodiumConcentration"
}
]
}
| 0 |
{
"document": "Renal sodium wasting An abnormally increased sodium concentration in the urine in the presence of hyponatremia. [{'predicate': 'subClassOf', 'target': 'AbnormalUrineSodiumConcentration'}]"
}
|
{
"aliases": null,
"definition": "Abnormal fat accumulation in the kidneys.",
"id": "RenalSteatosis",
"label": "Renal steatosis",
"logical_definition": null,
"original_id": "HP:0000799",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalMorphology"
}
]
}
| 0 |
{
"document": "Renal steatosis Abnormal fat accumulation in the kidneys. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalMorphology'}]"
}
|
{
"aliases": null,
"definition": "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.",
"id": "RenalSystem",
"label": "renal system",
"logical_definition": null,
"original_id": "UBERON:0001008",
"relationships": [
{
"predicate": "ExistenceEndsDuring",
"target": "FullyFormedStage"
}
]
}
| 0 |
{
"document": "renal system The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. [{'predicate': 'ExistenceEndsDuring', 'target': 'FullyFormedStage'}]"
}
|
{
"aliases": null,
"definition": "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).",
"id": "RenalSystemProcess",
"label": "renal system process",
"logical_definition": null,
"original_id": "GO:0003014",
"relationships": [
{
"predicate": "subClassOf",
"target": "SystemProcess"
}
]
}
| 0 |
{
"document": "renal system process A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). [{'predicate': 'subClassOf', 'target': 'SystemProcess'}]"
}
|
{
"aliases": null,
"definition": "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.",
"id": "RenalSystemProcessInvolvedInRegulationOfBloodVolume",
"label": "renal system process involved in regulation of blood volume",
"logical_definition": null,
"original_id": "GO:0001977",
"relationships": [
{
"predicate": "PartOf",
"target": "RegulationOfBodyFluidLevels"
},
{
"predicate": "subClassOf",
"target": "RenalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure"
}
]
}
| 0 |
{
"document": "renal system process involved in regulation of blood volume A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. [{'predicate': 'PartOf', 'target': 'RegulationOfBodyFluidLevels'}, {'predicate': 'subClassOf', 'target': 'RenalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure'}]"
}
|
{
"aliases": null,
"definition": "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.",
"id": "RenalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure",
"label": "renal system process involved in regulation of systemic arterial blood pressure",
"logical_definition": null,
"original_id": "GO:0003071",
"relationships": [
{
"predicate": "PartOf",
"target": "RegulationOfSystemicArterialBloodPressure"
},
{
"predicate": "subClassOf",
"target": "RenalSystemProcess"
}
]
}
| 0 |
{
"document": "renal system process involved in regulation of systemic arterial blood pressure Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [{'predicate': 'PartOf', 'target': 'RegulationOfSystemicArterialBloodPressure'}, {'predicate': 'subClassOf', 'target': 'RenalSystemProcess'}]"
}
|
{
"aliases": null,
"definition": "A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice.",
"id": "RenalTransitionalCellCarcinoma",
"label": "Renal transitional cell carcinoma",
"logical_definition": null,
"original_id": "HP:0030409",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalNeoplasm"
}
]
}
| 0 |
{
"document": "Renal transitional cell carcinoma A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice. [{'predicate': 'subClassOf', 'target': 'RenalNeoplasm'}]"
}
|
{
"aliases": null,
"definition": "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis.",
"id": "RenalTubularAcidosis",
"label": "Renal tubular acidosis",
"logical_definition": null,
"original_id": "HP:0001947",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularDysfunction"
},
{
"predicate": "subClassOf",
"target": "MetabolicAcidosis"
}
]
}
| 0 |
{
"document": "Renal tubular acidosis Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis. [{'predicate': 'subClassOf', 'target': 'RenalTubularDysfunction'}, {'predicate': 'subClassOf', 'target': 'MetabolicAcidosis'}]"
}
|
{
"aliases": null,
"definition": "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage.",
"id": "RenalTubularAdenovirusInclusions",
"label": "Renal tubular adenovirus inclusions",
"logical_definition": null,
"original_id": "HP:0032954",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularViralCytopathicChanges"
}
]
}
| 0 |
{
"document": "Renal tubular adenovirus inclusions Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage. [{'predicate': 'subClassOf', 'target': 'RenalTubularViralCytopathicChanges'}]"
}
|
{
"aliases": null,
"definition": "The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules.",
"id": "RenalTubularAtrophy",
"label": "Renal tubular atrophy",
"logical_definition": null,
"original_id": "HP:0000092",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular atrophy The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Naked basement membranes without tubular epithelium.",
"id": "RenalTubularBasementMembraneDenudation",
"label": "Renal tubular basement membrane denudation",
"logical_definition": null,
"original_id": "HP:0032594",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalTubularBasementMembraneMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular basement membrane denudation Naked basement membranes without tubular epithelium. [{'predicate': 'subClassOf', 'target': 'AbnormalTubularBasementMembraneMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells.",
"id": "RenalTubularCyst",
"label": "Renal tubular cyst",
"logical_definition": null,
"original_id": "HP:0041050",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
},
{
"predicate": "subClassOf",
"target": "RenalCyst"
}
]
}
| 0 |
{
"document": "Renal tubular cyst Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}, {'predicate': 'subClassOf', 'target': 'RenalCyst'}]"
}
|
{
"aliases": null,
"definition": "Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages.",
"id": "RenalTubularCytomegalovirusInclusions",
"label": "Renal tubular cytomegalovirus inclusions",
"logical_definition": null,
"original_id": "HP:0032953",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularViralCytopathicChanges"
}
]
}
| 0 |
{
"document": "Renal tubular cytomegalovirus inclusions Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages. [{'predicate': 'subClassOf', 'target': 'RenalTubularViralCytopathicChanges'}]"
}
|
{
"aliases": null,
"definition": "Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid.",
"id": "RenalTubularDysfunction",
"label": "Renal tubular dysfunction",
"logical_definition": null,
"original_id": "HP:0000124",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalPhysiology"
}
]
}
| 0 |
{
"document": "Renal tubular dysfunction Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalPhysiology'}]"
}
|
{
"aliases": null,
"definition": "Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris.",
"id": "RenalTubularEpithelialCellApoptosis",
"label": "Renal tubular epithelial cell apoptosis",
"logical_definition": null,
"original_id": "HP:0032647",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell apoptosis Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "A type of cellular urinary cast composed of renal tubular epithelial cells.",
"id": "RenalTubularEpithelialCellCasts",
"label": "Renal tubular epithelial cell casts",
"logical_definition": null,
"original_id": "HP:0031198",
"relationships": [
{
"predicate": "subClassOf",
"target": "CellularUrinaryCasts"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell casts A type of cellular urinary cast composed of renal tubular epithelial cells. [{'predicate': 'subClassOf', 'target': 'CellularUrinaryCasts'}]"
}
|
{
"aliases": null,
"definition": "Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size.",
"id": "RenalTubularEpithelialCellCytoplasmicVacuolization",
"label": "Renal tubular epithelial cell cytoplasmic vacuolization",
"logical_definition": null,
"original_id": "HP:0032596",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell cytoplasmic vacuolization Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved.",
"id": "RenalTubularEpithelialCellDetachment",
"label": "Renal tubular epithelial cell detachment",
"logical_definition": null,
"original_id": "HP:0032595",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell detachment Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment.",
"id": "RenalTubularEpithelialCellHemosiderin",
"label": "Renal tubular epithelial cell hemosiderin",
"logical_definition": null,
"original_id": "HP:0032611",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell hemosiderin Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell.",
"id": "RenalTubularEpithelialCellHyalineDroplets",
"label": "Renal tubular epithelial cell hyaline droplets",
"logical_definition": null,
"original_id": "HP:0032600",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell hyaline droplets Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration.",
"id": "RenalTubularEpithelialCellMitosis",
"label": "Renal tubular epithelial cell mitosis",
"logical_definition": null,
"original_id": "HP:0032604",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell mitosis Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts.",
"id": "RenalTubularEpithelialCellSimplification",
"label": "Renal tubular epithelial cell simplification",
"logical_definition": null,
"original_id": "HP:0032603",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell simplification Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast.",
"id": "RenalTubularEpithelialCellSloughing",
"label": "Renal tubular epithelial cell sloughing",
"logical_definition": null,
"original_id": "HP:0032597",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell sloughing At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen.",
"id": "RenalTubularEpithelialCellSwelling",
"label": "Renal tubular epithelial cell swelling",
"logical_definition": null,
"original_id": "HP:0032607",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial cell swelling Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules.",
"id": "RenalTubularEpithelialLipofuscin",
"label": "Renal tubular epithelial lipofuscin",
"logical_definition": null,
"original_id": "HP:0032606",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubularEpithelialMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial lipofuscin Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubularEpithelialMorphology'}]"
}
|
{
"aliases": null,
"definition": "Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%).",
"id": "RenalTubularEpithelialNecrosis",
"label": "Renal tubular epithelial necrosis",
"logical_definition": null,
"original_id": "HP:0008682",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
},
{
"predicate": "subClassOf",
"target": "RenalNecrosis"
}
]
}
| 0 |
{
"document": "Renal tubular epithelial necrosis Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%). [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}, {'predicate': 'subClassOf', 'target': 'RenalNecrosis'}]"
}
|
{
"aliases": null,
"definition": "Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis.",
"id": "RenalTubularHerpesSimplexVirusInclusions",
"label": "Renal tubular herpes simplex virus inclusions",
"logical_definition": null,
"original_id": "HP:0032956",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularViralCytopathicChanges"
}
]
}
| 0 |
{
"document": "Renal tubular herpes simplex virus inclusions Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis. [{'predicate': 'subClassOf', 'target': 'RenalTubularViralCytopathicChanges'}]"
}
|
{
"aliases": null,
"definition": null,
"id": "RenalTubularLysineTransportDefect",
"label": "Renal tubular lysine transport defect",
"logical_definition": null,
"original_id": "HP:0008272",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularDysfunction"
}
]
}
| 0 |
{
"document": "Renal tubular lysine transport defect None [{'predicate': 'subClassOf', 'target': 'RenalTubularDysfunction'}]"
}
|
{
"aliases": null,
"definition": "Renal ltubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection.",
"id": "RenalTubularPolyomaVirusInclusions",
"label": "Renal tubular polyoma virus inclusions",
"logical_definition": null,
"original_id": "HP:0032955",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalTubularViralCytopathicChanges"
}
]
}
| 0 |
{
"document": "Renal tubular polyoma virus inclusions Renal ltubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection. [{'predicate': 'subClassOf', 'target': 'RenalTubularViralCytopathicChanges'}]"
}
|
{
"aliases": null,
"definition": "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.",
"id": "RenalTubularSecretion",
"label": "renal tubular secretion",
"logical_definition": null,
"original_id": "GO:0097254",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalSystemProcess"
},
{
"predicate": "subClassOf",
"target": "Excretion"
}
]
}
| 0 |
{
"document": "renal tubular secretion The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. [{'predicate': 'subClassOf', 'target': 'RenalSystemProcess'}, {'predicate': 'subClassOf', 'target': 'Excretion'}]"
}
|
{
"aliases": null,
"definition": "Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells.",
"id": "RenalTubularViralCytopathicChanges",
"label": "Renal tubular viral cytopathic changes",
"logical_definition": null,
"original_id": "HP:0032951",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renal tubular viral cytopathic changes Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": "A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.",
"id": "RenalTubule",
"label": "renal tubule",
"logical_definition": null,
"original_id": "UBERON:0009773",
"relationships": [
{
"predicate": "PartOf",
"target": "RenalSystem"
},
{
"predicate": "subClassOf",
"target": "EpithelialTube"
}
]
}
| 0 |
{
"document": "renal tubule A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. [{'predicate': 'PartOf', 'target': 'RenalSystem'}, {'predicate': 'subClassOf', 'target': 'EpithelialTube'}]"
}
|
{
"aliases": null,
"definition": "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava.",
"id": "RenalVein",
"label": "renal vein",
"logical_definition": null,
"original_id": "UBERON:0001140",
"relationships": [
{
"predicate": "TributaryOf",
"target": "PosteriorVenaCava"
},
{
"predicate": "subClassOf",
"target": "Vein"
}
]
}
| 0 |
{
"document": "renal vein Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava. [{'predicate': 'TributaryOf', 'target': 'PosteriorVenaCava'}, {'predicate': 'subClassOf', 'target': 'Vein'}]"
}
|
{
"aliases": null,
"definition": "The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output.",
"id": "RenalVeinThrombosis",
"label": "Renal vein thrombosis",
"logical_definition": null,
"original_id": "HP:0034239",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalVascularMorphology"
}
]
}
| 0 |
{
"document": "Renal vein thrombosis The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalVascularMorphology'}]"
}
|
{
"aliases": null,
"definition": "Any member of the network of tubes that return blood from the renal tissues to the systemic circulation.",
"id": "RenalVenousBloodVessel",
"label": "renal venous blood vessel",
"logical_definition": null,
"original_id": "UBERON:0014401",
"relationships": null
}
| 0 |
{
"document": "renal venous blood vessel Any member of the network of tubes that return blood from the renal tissues to the systemic circulation. None"
}
|
{
"aliases": null,
"definition": "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.",
"id": "RenalVesicle",
"label": "renal vesicle",
"logical_definition": null,
"original_id": "UBERON:0004209",
"relationships": [
{
"predicate": "PartOf",
"target": "NephronProgenitor"
},
{
"predicate": "DevelopsFrom",
"target": "NephrogenicMesenchyme"
},
{
"predicate": "DevelopmentallyInducedBy",
"target": "UretericBud"
},
{
"predicate": "HasPotentialToDevelopInto",
"target": "NephronEpithelium"
},
{
"predicate": "subClassOf",
"target": "EpithelialVesicle"
}
]
}
| 0 |
{
"document": "renal vesicle The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [{'predicate': 'PartOf', 'target': 'NephronProgenitor'}, {'predicate': 'DevelopsFrom', 'target': 'NephrogenicMesenchyme'}, {'predicate': 'DevelopmentallyInducedBy', 'target': 'UretericBud'}, {'predicate': 'HasPotentialToDevelopInto', 'target': 'NephronEpithelium'}, {'predicate': 'subClassOf', 'target': 'EpithelialVesicle'}]"
}
|
{
"aliases": null,
"definition": "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.",
"id": "RenalWaterAbsorption",
"label": "renal water absorption",
"logical_definition": null,
"original_id": "GO:0070295",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalWaterTransport"
},
{
"predicate": "subClassOf",
"target": "RenalAbsorption"
}
]
}
| 0 |
{
"document": "renal water absorption A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [{'predicate': 'subClassOf', 'target': 'RenalWaterTransport'}, {'predicate': 'subClassOf', 'target': 'RenalAbsorption'}]"
}
|
{
"aliases": null,
"definition": "Renal process involved in the maintenance of an internal steady state of water in the body.",
"id": "RenalWaterHomeostasis",
"label": "renal water homeostasis",
"logical_definition": null,
"original_id": "GO:0003091",
"relationships": [
{
"predicate": "subClassOf",
"target": "RenalSystemProcess"
},
{
"predicate": "subClassOf",
"target": "MulticellularOrganismalLevelWaterHomeostasis"
}
]
}
| 0 |
{
"document": "renal water homeostasis Renal process involved in the maintenance of an internal steady state of water in the body. [{'predicate': 'subClassOf', 'target': 'RenalSystemProcess'}, {'predicate': 'subClassOf', 'target': 'MulticellularOrganismalLevelWaterHomeostasis'}]"
}
|
{
"aliases": null,
"definition": "The directed movement of water (H2O) by the renal system.",
"id": "RenalWaterTransport",
"label": "renal water transport",
"logical_definition": null,
"original_id": "GO:0003097",
"relationships": [
{
"predicate": "PartOf",
"target": "RenalWaterHomeostasis"
},
{
"predicate": "subClassOf",
"target": "RenalSystemProcess"
},
{
"predicate": "subClassOf",
"target": "WaterTransport"
}
]
}
| 0 |
{
"document": "renal water transport The directed movement of water (H2O) by the renal system. [{'predicate': 'PartOf', 'target': 'RenalWaterHomeostasis'}, {'predicate': 'subClassOf', 'target': 'RenalSystemProcess'}, {'predicate': 'subClassOf', 'target': 'WaterTransport'}]"
}
|
{
"aliases": null,
"definition": "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.",
"id": "Renin",
"label": "renin",
"logical_definition": null,
"original_id": "PR:000013883",
"relationships": [
{
"predicate": "subClassOf",
"target": "Angiotensinogenase"
}
]
}
| 0 |
{
"document": "renin An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof. [{'predicate': 'subClassOf', 'target': 'Angiotensinogenase'}]"
}
|
{
"aliases": null,
"definition": "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.",
"id": "ReninAngiotensinRegulationOfAldosteroneProduction",
"label": "renin-angiotensin regulation of aldosterone production",
"logical_definition": null,
"original_id": "GO:0002018",
"relationships": [
{
"predicate": "PartOf",
"target": "RegulationOfBloodVolumeByReninAngiotensin"
},
{
"predicate": "subClassOf",
"target": "RenalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure"
},
{
"predicate": "subClassOf",
"target": "RegulationOfAldosteroneSecretion"
}
]
}
| 0 |
{
"document": "renin-angiotensin regulation of aldosterone production The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. [{'predicate': 'PartOf', 'target': 'RegulationOfBloodVolumeByReninAngiotensin'}, {'predicate': 'subClassOf', 'target': 'RenalSystemProcessInvolvedInRegulationOfSystemicArterialBloodPressure'}, {'predicate': 'subClassOf', 'target': 'RegulationOfAldosteroneSecretion'}]"
}
|
{
"aliases": null,
"definition": "A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex.",
"id": "ReninAngiotensinSystem",
"label": "renin-angiotensin system",
"logical_definition": null,
"original_id": "UBERON:0018229",
"relationships": [
{
"predicate": "PartOf",
"target": "EndocrineSystem"
},
{
"predicate": "CapableOf",
"target": "RegulationOfBloodVolumeByReninAngiotensin"
},
{
"predicate": "subClassOf",
"target": "OrganSystemSubdivision"
}
]
}
| 0 |
{
"document": "renin-angiotensin system A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex. [{'predicate': 'PartOf', 'target': 'EndocrineSystem'}, {'predicate': 'CapableOf', 'target': 'RegulationOfBloodVolumeByReninAngiotensin'}, {'predicate': 'subClassOf', 'target': 'OrganSystemSubdivision'}]"
}
|
{
"aliases": null,
"definition": "A developmental defect characterized by absence or poor development of proximal renal tubules.",
"id": "RenotubularDysgenesis",
"label": "Renotubular dysgenesis",
"logical_definition": null,
"original_id": "HP:0008660",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalRenalTubuleMorphology"
}
]
}
| 0 |
{
"document": "Renotubular dysgenesis A developmental defect characterized by absence or poor development of proximal renal tubules. [{'predicate': 'subClassOf', 'target': 'AbnormalRenalTubuleMorphology'}]"
}
|
{
"aliases": null,
"definition": "The presence of hypertension related to stenosis of the renal artery.",
"id": "RenovascularHypertension",
"label": "Renovascular hypertension",
"logical_definition": null,
"original_id": "HP:0100817",
"relationships": [
{
"predicate": "subClassOf",
"target": "Hypertension"
},
{
"predicate": "subClassOf",
"target": "AbnormalRenalPhysiology"
}
]
}
| 0 |
{
"document": "Renovascular hypertension The presence of hypertension related to stenosis of the renal artery. [{'predicate': 'subClassOf', 'target': 'Hypertension'}, {'predicate': 'subClassOf', 'target': 'AbnormalRenalPhysiology'}]"
}
|
{
"aliases": null,
"definition": "A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus.",
"id": "RepeatedFocalMotorSeizures",
"label": "Repeated focal motor seizures",
"logical_definition": null,
"original_id": "HP:0032665",
"relationships": [
{
"predicate": "subClassOf",
"target": "FocalMotorStatusEpilepticus"
}
]
}
| 0 |
{
"document": "Repeated focal motor seizures A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus. [{'predicate': 'subClassOf', 'target': 'FocalMotorStatusEpilepticus'}]"
}
|
{
"aliases": null,
"definition": "Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles.",
"id": "RepeatedImplantationFailure",
"label": "Repeated implantation failure",
"logical_definition": null,
"original_id": "HP:0033712",
"relationships": [
{
"predicate": "subClassOf",
"target": "AbnormalPreimplantationEmbryonicDevelopment"
}
]
}
| 0 |
{
"document": "Repeated implantation failure Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. [{'predicate': 'subClassOf', 'target': 'AbnormalPreimplantationEmbryonicDevelopment'}]"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.