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{ "aliases": null, "definition": null, "id": "AcyclicAcidAnhydride", "label": "acyclic acid anhydride", "logical_definition": null, "original_id": "CHEBI:36608", "relationships": [ { "predicate": "subClassOf", "target": "AcidAnhydride" } ] }
0
{ "document": "acyclic acid anhydride None [{'predicate': 'subClassOf', 'target': 'AcidAnhydride'}]" }
{ "aliases": null, "definition": null, "id": "AcyclicPhosphorusAcidAnhydride", "label": "acyclic phosphorus acid anhydride", "logical_definition": null, "original_id": "CHEBI:37786", "relationships": [ { "predicate": "subClassOf", "target": "AcyclicAcidAnhydride" } ] }
0
{ "document": "acyclic phosphorus acid anhydride None [{'predicate': 'subClassOf', 'target': 'AcyclicAcidAnhydride'}]" }
{ "aliases": null, "definition": "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.", "id": "AcylGroup", "label": "acyl group", "logical_definition": null, "original_id": "CHEBI:22221", "relationships": [ { "predicate": "subClassOf", "target": "OrganicGroup" } ] }
0
{ "document": "acyl group An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids. [{'predicate': 'subClassOf', 'target': 'OrganicGroup'}]" }
{ "aliases": null, "definition": "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).", "id": "AcyltransferaseActivity", "label": "acyltransferase activity", "logical_definition": null, "original_id": "GO:0016746", "relationships": [ { "predicate": "subClassOf", "target": "TransferaseActivity" } ] }
0
{ "document": "acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [{'predicate': 'subClassOf', 'target': 'TransferaseActivity'}]" }
{ "aliases": null, "definition": "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).", "id": "AcyltransferaseActivity_transferringGroupsOtherThanAminoAcylGroups", "label": "acyltransferase activity, transferring groups other than amino-acyl groups", "logical_definition": null, "original_id": "GO:0016747", "relationships": [ { "predicate": "subClassOf", "target": "AcyltransferaseActivity" } ] }
0
{ "document": "acyltransferase activity, transferring groups other than amino-acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). [{'predicate': 'subClassOf', 'target': 'AcyltransferaseActivity'}]" }
{ "aliases": null, "definition": "The absence of all phalanges of all the digits of a limb and the associated soft tissues.", "id": "Adactyly", "label": "Adactyly", "logical_definition": null, "original_id": "HP:0009776", "relationships": [ { "predicate": "subClassOf", "target": "AplasiaOfTheFingers" }, { "predicate": "subClassOf", "target": "AbsentToe" } ] }
0
{ "document": "Adactyly The absence of all phalanges of all the digits of a limb and the associated soft tissues. [{'predicate': 'subClassOf', 'target': 'AplasiaOfTheFingers'}, {'predicate': 'subClassOf', 'target': 'AbsentToe'}]" }
{ "aliases": null, "definition": "A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.", "id": "Adamantinoma", "label": "Adamantinoma", "logical_definition": null, "original_id": "HP:0034525", "relationships": [ { "predicate": "subClassOf", "target": "NeoplasmOfTheSkeletalSystem" } ] }
0
{ "document": "Adamantinoma A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns. [{'predicate': 'subClassOf', 'target': 'NeoplasmOfTheSkeletalSystem'}]" }
{ "aliases": null, "definition": "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).", "id": "AdaptiveImmuneResponse", "label": "adaptive immune response", "logical_definition": null, "original_id": "GO:0002250", "relationships": [ { "predicate": "subClassOf", "target": "ImmuneResponse" } ] }
0
{ "document": "adaptive immune response An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [{'predicate': 'subClassOf', 'target': 'ImmuneResponse'}]" }
{ "aliases": null, "definition": "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.", "id": "AdaptiveImmuneResponseBasedOnSomaticRecombinationOfImmuneReceptorsBuiltFromImmunoglobulinSuperfamilyDomains", "label": "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "logical_definition": null, "original_id": "GO:0002460", "relationships": [ { "predicate": "subClassOf", "target": "AdaptiveImmuneResponse" } ] }
0
{ "document": "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. [{'predicate': 'subClassOf', 'target': 'AdaptiveImmuneResponse'}]" }
{ "aliases": null, "definition": "When an activity, substance, object, or behavior becomes a major focus of a person's life excluding other activities, or has begun to harm the individual or others physically, mentally, or socially can be considered addictive behavior. A person can become addicted or compulsively engaged with anything.", "id": "AddictiveBehavior", "label": "Addictive behavior", "logical_definition": null, "original_id": "HP:0030858", "relationships": [ { "predicate": "subClassOf", "target": "ReducedImpulseControl" } ] }
0
{ "document": "Addictive behavior When an activity, substance, object, or behavior becomes a major focus of a person's life excluding other activities, or has begun to harm the individual or others physically, mentally, or socially can be considered addictive behavior. A person can become addicted or compulsively engaged with anything. [{'predicate': 'subClassOf', 'target': 'ReducedImpulseControl'}]" }
{ "aliases": null, "definition": "Supernumerary ridge or crus of the ear arising from the antihelix.", "id": "AdditionalCrusOfAntihelix", "label": "Additional crus of antihelix", "logical_definition": null, "original_id": "HP:0011235", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalAntihelixMorphology" } ] }
0
{ "document": "Additional crus of antihelix Supernumerary ridge or crus of the ear arising from the antihelix. [{'predicate': 'subClassOf', 'target': 'AbnormalAntihelixMorphology'}]" }
{ "aliases": null, "definition": "In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger.", "id": "AdductedThumb", "label": "Adducted thumb", "logical_definition": null, "original_id": "HP:0001181", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalThumbMorphology" } ] }
0
{ "document": "Adducted thumb In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger. [{'predicate': 'subClassOf', 'target': 'AbnormalThumbMorphology'}]" }
{ "aliases": null, "definition": "An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized].", "id": "AdductorLongus", "label": "adductor longus", "logical_definition": null, "original_id": "UBERON:0000303", "relationships": [ { "predicate": "PartOf", "target": "HindlimbStylopod" }, { "predicate": "HasMuscleOrigin", "target": "Pubis" }, { "predicate": "HasMuscleInsertion", "target": "Femur" }, { "predicate": "subClassOf", "target": "AdductorMuscleOfHip" } ] }
0
{ "document": "adductor longus An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized]. [{'predicate': 'PartOf', 'target': 'HindlimbStylopod'}, {'predicate': 'HasMuscleOrigin', 'target': 'Pubis'}, {'predicate': 'HasMuscleInsertion', 'target': 'Femur'}, {'predicate': 'subClassOf', 'target': 'AdductorMuscleOfHip'}]" }
{ "aliases": null, "definition": null, "id": "AdductorLongusContractures", "label": "Adductor longus contractures", "logical_definition": null, "original_id": "HP:0006366", "relationships": [ { "predicate": "subClassOf", "target": "LowerLimbJointContracture" } ] }
0
{ "document": "Adductor longus contractures None [{'predicate': 'subClassOf', 'target': 'LowerLimbJointContracture'}]" }
{ "aliases": null, "definition": "A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction.", "id": "AdductorMuscle", "label": "adductor muscle", "logical_definition": null, "original_id": "UBERON:0011145", "relationships": [ { "predicate": "subClassOf", "target": "SkeletalMuscleOrgan" } ] }
0
{ "document": "adductor muscle A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction. [{'predicate': 'subClassOf', 'target': 'SkeletalMuscleOrgan'}]" }
{ "aliases": null, "definition": ".", "id": "AdductorMuscleOfHip", "label": "adductor muscle of hip", "logical_definition": null, "original_id": "UBERON:0011144", "relationships": [ { "predicate": "InnervatedBy", "target": "ObturatorNerve" }, { "predicate": "HasMuscleOrigin", "target": "InnominateBone" } ] }
0
{ "document": "adductor muscle of hip . [{'predicate': 'InnervatedBy', 'target': 'ObturatorNerve'}, {'predicate': 'HasMuscleOrigin', 'target': 'InnominateBone'}]" }
{ "aliases": null, "definition": "The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.", "id": "Adenine", "label": "adenine", "logical_definition": null, "original_id": "CHEBI:16708", "relationships": [ { "predicate": "HasRole", "target": "MouseMetabolite" }, { "predicate": "HasRole", "target": "SaccharomycesCerevisiaeMetabolite" }, { "predicate": "HasRole", "target": "EscherichiaColiMetabolite" }, { "predicate": "HasRole", "target": "HumanMetabolite" }, { "predicate": "HasRole", "target": "DaphniaMagnaMetabolite" }, { "predicate": "obo:chebi#has_parent_hydride", "target": "9HPurine" }, { "predicate": "subClassOf", "target": "6Aminopurines" }, { "predicate": "subClassOf", "target": "PurineNucleobase" } ] }
0
{ "document": "adenine The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. [{'predicate': 'HasRole', 'target': 'MouseMetabolite'}, {'predicate': 'HasRole', 'target': 'SaccharomycesCerevisiaeMetabolite'}, {'predicate': 'HasRole', 'target': 'EscherichiaColiMetabolite'}, {'predicate': 'HasRole', 'target': 'HumanMetabolite'}, {'predicate': 'HasRole', 'target': 'DaphniaMagnaMetabolite'}, {'predicate': 'obo:chebi#has_parent_hydride', 'target': '9HPurine'}, {'predicate': 'subClassOf', 'target': '6Aminopurines'}, {'predicate': 'subClassOf', 'target': 'PurineNucleobase'}]" }
{ "aliases": null, "definition": null, "id": "AdenocarcinomaOfTheColon", "label": "Adenocarcinoma of the colon", "logical_definition": null, "original_id": "HP:0040276", "relationships": [ { "predicate": "subClassOf", "target": "AdenocarcinomaOfTheLargeIntestine" }, { "predicate": "subClassOf", "target": "NeoplasmOfTheColon" } ] }
0
{ "document": "Adenocarcinoma of the colon None [{'predicate': 'subClassOf', 'target': 'AdenocarcinomaOfTheLargeIntestine'}, {'predicate': 'subClassOf', 'target': 'NeoplasmOfTheColon'}]" }
{ "aliases": null, "definition": "A malignant epithelial tumor with a glandular organization that originates in the intestines.", "id": "AdenocarcinomaOfTheIntestines", "label": "Adenocarcinoma of the intestines", "logical_definition": null, "original_id": "HP:0040273", "relationships": [ { "predicate": "subClassOf", "target": "GastrointestinalCarcinoma" } ] }
0
{ "document": "Adenocarcinoma of the intestines A malignant epithelial tumor with a glandular organization that originates in the intestines. [{'predicate': 'subClassOf', 'target': 'GastrointestinalCarcinoma'}]" }
{ "aliases": null, "definition": "A malignant epithelial tumor with a glandular organization that originates in the large intestine.", "id": "AdenocarcinomaOfTheLargeIntestine", "label": "Adenocarcinoma of the large intestine", "logical_definition": null, "original_id": "HP:0040275", "relationships": [ { "predicate": "subClassOf", "target": "AdenocarcinomaOfTheIntestines" }, { "predicate": "subClassOf", "target": "NeoplasmOfTheLargeIntestine" } ] }
0
{ "document": "Adenocarcinoma of the large intestine A malignant epithelial tumor with a glandular organization that originates in the large intestine. [{'predicate': 'subClassOf', 'target': 'AdenocarcinomaOfTheIntestines'}, {'predicate': 'subClassOf', 'target': 'NeoplasmOfTheLargeIntestine'}]" }
{ "aliases": null, "definition": "A malignant epithelial tumor with a glandular organization that originates in the small intestine.", "id": "AdenocarcinomaOfTheSmallIntestine", "label": "Adenocarcinoma of the small intestine", "logical_definition": null, "original_id": "HP:0040274", "relationships": [ { "predicate": "subClassOf", "target": "AdenocarcinomaOfTheIntestines" }, { "predicate": "subClassOf", "target": "NeoplasmOfTheSmallIntestine" } ] }
0
{ "document": "Adenocarcinoma of the small intestine A malignant epithelial tumor with a glandular organization that originates in the small intestine. [{'predicate': 'subClassOf', 'target': 'AdenocarcinomaOfTheIntestines'}, {'predicate': 'subClassOf', 'target': 'NeoplasmOfTheSmallIntestine'}]" }
{ "aliases": null, "definition": "The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary.", "id": "AdenohypophysealPlacode", "label": "adenohypophyseal placode", "logical_definition": null, "original_id": "UBERON:0009122", "relationships": [ { "predicate": "DevelopsFrom", "target": "NonNeuralEctoderm" }, { "predicate": "subClassOf", "target": "CranialPlacode" }, { "predicate": "subClassOf", "target": "NonNeurogenicEctodermalPlacode" } ] }
0
{ "document": "adenohypophyseal placode The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary. [{'predicate': 'DevelopsFrom', 'target': 'NonNeuralEctoderm'}, {'predicate': 'subClassOf', 'target': 'CranialPlacode'}, {'predicate': 'subClassOf', 'target': 'NonNeurogenicEctodermalPlacode'}]" }
{ "aliases": null, "definition": "The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA].", "id": "Adenohypophysis", "label": "adenohypophysis", "logical_definition": null, "original_id": "UBERON:0002196", "relationships": [ { "predicate": "PartOf", "target": "PituitaryGland" }, { "predicate": "HasPart", "target": "SomatotropinSecretingCell" }, { "predicate": "HasPart", "target": "LuteinizingHormoneSecretingCell" }, { "predicate": "HasPart", "target": "ProlactinSecretingCell" }, { "predicate": "HasPart", "target": "AdrenocorticotropicHormoneSecretingCell" }, { "predicate": "HasPart", "target": "Somatotroph" }, { "predicate": "DevelopsFrom", "target": "AdenohypophysealPlacode" }, { "predicate": "ContributesToMorphologyOf", "target": "PituitaryGland" }, { "predicate": "subClassOf", "target": "OrganPart" } ] }
0
{ "document": "adenohypophysis The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA]. [{'predicate': 'PartOf', 'target': 'PituitaryGland'}, {'predicate': 'HasPart', 'target': 'SomatotropinSecretingCell'}, {'predicate': 'HasPart', 'target': 'LuteinizingHormoneSecretingCell'}, {'predicate': 'HasPart', 'target': 'ProlactinSecretingCell'}, {'predicate': 'HasPart', 'target': 'AdrenocorticotropicHormoneSecretingCell'}, {'predicate': 'HasPart', 'target': 'Somatotroph'}, {'predicate': 'DevelopsFrom', 'target': 'AdenohypophysealPlacode'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'PituitaryGland'}, {'predicate': 'subClassOf', 'target': 'OrganPart'}]" }
{ "aliases": null, "definition": "An inflammation of the adenoid tissue.", "id": "Adenoiditis", "label": "Adenoiditis", "logical_definition": null, "original_id": "HP:0031458", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalNasopharyngealAdenoidMorphology" } ] }
0
{ "document": "Adenoiditis An inflammation of the adenoid tissue. [{'predicate': 'subClassOf', 'target': 'AbnormalNasopharyngealAdenoidMorphology'}]" }
{ "aliases": null, "definition": "A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.", "id": "Adenoma", "label": "adenoma", "logical_definition": null, "original_id": "MPATH:270", "relationships": [ { "predicate": "subClassOf", "target": "GlandularTumor" }, { "predicate": "subClassOf", "target": "PotentiallyCancerousLesions" } ] }
0
{ "document": "adenoma A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy. [{'predicate': 'subClassOf', 'target': 'GlandularTumor'}, {'predicate': 'subClassOf', 'target': 'PotentiallyCancerousLesions'}]" }
{ "aliases": null, "definition": "The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin.", "id": "AdenomaSebaceum", "label": "Adenoma sebaceum", "logical_definition": null, "original_id": "HP:0009720", "relationships": [ { "predicate": "subClassOf", "target": "NeoplasmOfTheSkin" }, { "predicate": "subClassOf", "target": "Angiofibromas" }, { "predicate": "subClassOf", "target": "AbnormalityOfFacialSoftTissue" } ] }
0
{ "document": "Adenoma sebaceum The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin. [{'predicate': 'subClassOf', 'target': 'NeoplasmOfTheSkin'}, {'predicate': 'subClassOf', 'target': 'Angiofibromas'}, {'predicate': 'subClassOf', 'target': 'AbnormalityOfFacialSoftTissue'}]" }
{ "aliases": null, "definition": "Presence of multiple adenomatous polyps in the colon.", "id": "AdenomatousColonicPolyposis", "label": "Adenomatous colonic polyposis", "logical_definition": null, "original_id": "HP:0005227", "relationships": [ { "predicate": "subClassOf", "target": "LargeIntestinalPolyposis" }, { "predicate": "subClassOf", "target": "NeoplasmOfTheColon" } ] }
0
{ "document": "Adenomatous colonic polyposis Presence of multiple adenomatous polyps in the colon. [{'predicate': 'subClassOf', 'target': 'LargeIntestinalPolyposis'}, {'predicate': 'subClassOf', 'target': 'NeoplasmOfTheColon'}]" }
{ "aliases": null, "definition": "Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding.", "id": "Adenomyosis", "label": "Adenomyosis", "logical_definition": null, "original_id": "HP:0034326", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalUterusMorphology" } ] }
0
{ "document": "Adenomyosis Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding. [{'predicate': 'subClassOf', 'target': 'AbnormalUterusMorphology'}]" }
{ "aliases": null, "definition": null, "id": "Adermatoglyphia", "label": "Adermatoglyphia", "logical_definition": null, "original_id": "HP:0007455", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalDermatoglyphics" } ] }
0
{ "document": "Adermatoglyphia None [{'predicate': 'subClassOf', 'target': 'AbnormalDermatoglyphics'}]" }
{ "aliases": null, "definition": "A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs.", "id": "AdhesionGProteinCoupledReceptor", "label": "adhesion G-protein coupled receptor", "logical_definition": null, "original_id": "PR:000001087", "relationships": [ { "predicate": "subClassOf", "target": "GProteinCoupledReceptor" } ] }
0
{ "document": "adhesion G-protein coupled receptor A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs. [{'predicate': 'subClassOf', 'target': 'GProteinCoupledReceptor'}]" }
{ "aliases": null, "definition": "An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof.", "id": "AdhesionGProteinCoupledReceptorE1", "label": "adhesion G protein-coupled receptor E1", "logical_definition": null, "original_id": "PR:000001813", "relationships": [ { "predicate": "subClassOf", "target": "AdhesionGProteinCoupledReceptor" } ] }
0
{ "document": "adhesion G protein-coupled receptor E1 An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof. [{'predicate': 'subClassOf', 'target': 'AdhesionGProteinCoupledReceptor'}]" }
{ "aliases": null, "definition": "An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.", "id": "AdipocyteHypertrophy", "label": "Adipocyte hypertrophy", "logical_definition": null, "original_id": "HP:0030759", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalAdiposeTissueMorphology" } ] }
0
{ "document": "Adipocyte hypertrophy An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy. [{'predicate': 'subClassOf', 'target': 'AbnormalAdiposeTissueMorphology'}]" }
{ "aliases": null, "definition": "A fat cell that is part of the breast.", "id": "AdipocyteOfBreast", "label": "adipocyte of breast", "logical_definition": null, "original_id": "CL:0002617", "relationships": [ { "predicate": "subClassOf", "target": "FatCell" } ] }
0
{ "document": "adipocyte of breast A fat cell that is part of the breast. [{'predicate': 'subClassOf', 'target': 'FatCell'}]" }
{ "aliases": null, "definition": "A fat cell that is part of the epicardial fat of left ventricle.", "id": "AdipocyteOfEpicardialFatOfLeftVentricle", "label": "adipocyte of epicardial fat of left ventricle", "logical_definition": null, "original_id": "CL:1000311", "relationships": [ { "predicate": "PartOf", "target": "HeartLeftVentricle" }, { "predicate": "subClassOf", "target": "FatCell" } ] }
0
{ "document": "adipocyte of epicardial fat of left ventricle A fat cell that is part of the epicardial fat of left ventricle. [{'predicate': 'PartOf', 'target': 'HeartLeftVentricle'}, {'predicate': 'subClassOf', 'target': 'FatCell'}]" }
{ "aliases": null, "definition": "A fat cell that is part of the epicardial fat of right ventricle.", "id": "AdipocyteOfEpicardialFatOfRightVentricle", "label": "adipocyte of epicardial fat of right ventricle", "logical_definition": null, "original_id": "CL:1000310", "relationships": [ { "predicate": "PartOf", "target": "HeartRightVentricle" }, { "predicate": "subClassOf", "target": "FatCell" } ] }
0
{ "document": "adipocyte of epicardial fat of right ventricle A fat cell that is part of the epicardial fat of right ventricle. [{'predicate': 'PartOf', 'target': 'HeartRightVentricle'}, {'predicate': 'subClassOf', 'target': 'FatCell'}]" }
{ "aliases": null, "definition": "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.", "id": "Adiponectin", "label": "adiponectin", "logical_definition": null, "original_id": "PR:000003777", "relationships": [ { "predicate": "subClassOf", "target": "Protein_PR:000000001" } ] }
0
{ "document": "adiponectin A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof. [{'predicate': 'subClassOf', 'target': 'Protein_PR:000000001'}]" }
{ "aliases": null, "definition": "An adiponectin that is encoded in the genome of human.", "id": "Adiponectin_human_", "label": "adiponectin (human)", "logical_definition": null, "original_id": "PR:Q15848", "relationships": [ { "predicate": "subClassOf", "target": "Adiponectin" }, { "predicate": "subClassOf", "target": "HomoSapiensProtein" } ] }
0
{ "document": "adiponectin (human) An adiponectin that is encoded in the genome of human. [{'predicate': 'subClassOf', 'target': 'Adiponectin'}, {'predicate': 'subClassOf', 'target': 'HomoSapiensProtein'}]" }
{ "aliases": null, "definition": "A F4/80-negative dendritic cell located in adipose tissue.", "id": "AdiposeDendriticCell", "label": "adipose dendritic cell", "logical_definition": null, "original_id": "CL:0002462", "relationships": [ { "predicate": "DevelopsFrom", "target": "PreConventionalDendriticCell" }, { "predicate": "subClassOf", "target": "ConventionalDendriticCell" } ] }
0
{ "document": "adipose dendritic cell A F4/80-negative dendritic cell located in adipose tissue. [{'predicate': 'DevelopsFrom', 'target': 'PreConventionalDendriticCell'}, {'predicate': 'subClassOf', 'target': 'ConventionalDendriticCell'}]" }
{ "aliases": null, "definition": "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive.", "id": "AdiposeMacrophage", "label": "adipose macrophage", "logical_definition": null, "original_id": "CL:0002477", "relationships": [ { "predicate": "subClassOf", "target": "TissueResidentMacrophage" } ] }
0
{ "document": "adipose macrophage A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive. [{'predicate': 'subClassOf', 'target': 'TissueResidentMacrophage'}]" }
{ "aliases": null, "definition": "Any microvascular endothelial cell that is part of a adipose tissue.", "id": "AdiposeMicrovascularEndothelialCell", "label": "adipose microvascular endothelial cell", "logical_definition": null, "original_id": "CL:2000072", "relationships": null }
0
{ "document": "adipose microvascular endothelial cell Any microvascular endothelial cell that is part of a adipose tissue. None" }
{ "aliases": null, "definition": "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.", "id": "AdiposeTissue", "label": "adipose tissue", "logical_definition": null, "original_id": "UBERON:0001013", "relationships": [ { "predicate": "subClassOf", "target": "DenseIrregularConnectiveTissue" } ] }
0
{ "document": "adipose tissue Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. [{'predicate': 'subClassOf', 'target': 'DenseIrregularConnectiveTissue'}]" }
{ "aliases": null, "definition": "A loss of adipose tissue.", "id": "AdiposeTissueLoss", "label": "Adipose tissue loss", "logical_definition": null, "original_id": "HP:0008887", "relationships": [ { "predicate": "subClassOf", "target": "DecreasedAdiposeTissue" } ] }
0
{ "document": "Adipose tissue loss A loss of adipose tissue. [{'predicate': 'subClassOf', 'target': 'DecreasedAdiposeTissue'}]" }
{ "aliases": null, "definition": "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.", "id": "AdiposeTissueOfAbdominalRegion", "label": "adipose tissue of abdominal region", "logical_definition": null, "original_id": "UBERON:0007808", "relationships": null }
0
{ "document": "adipose tissue of abdominal region Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. None" }
{ "aliases": null, "definition": "A pathological drinking behavior characterised by a lack of desire to drink.", "id": "Adipsia", "label": "adipsia", "logical_definition": null, "original_id": "NBO:0002519", "relationships": [ { "predicate": "subClassOf", "target": "DecreasedFrequencyOfDrinking" } ] }
0
{ "document": "adipsia A pathological drinking behavior characterised by a lack of desire to drink. [{'predicate': 'subClassOf', 'target': 'DecreasedFrequencyOfDrinking'}]" }
{ "aliases": null, "definition": "x adjacent to y if and only if x and y share a boundary.", "id": "AdjacentTo", "label": "adjacent to", "logical_definition": null, "original_id": "RO:0002220", "relationships": [ { "predicate": "subPropertyOf", "target": "SpatiallyDisjointFrom" }, { "predicate": "domain", "target": "IndependentContinuant" }, { "predicate": "range", "target": "IndependentContinuant" } ] }
0
{ "document": "adjacent to x adjacent to y if and only if x and y share a boundary. [{'predicate': 'subPropertyOf', 'target': 'SpatiallyDisjointFrom'}, {'predicate': 'domain', 'target': 'IndependentContinuant'}, {'predicate': 'range', 'target': 'IndependentContinuant'}]" }
{ "aliases": null, "definition": "Mature stage that refers to an adolescent who is over 13 and under 19 years old.", "id": "AdolescentStage", "label": "adolescent stage", "logical_definition": null, "original_id": "HsapDv:0000086", "relationships": [ { "predicate": "PartOf", "target": "MatureStage" }, { "predicate": "subClassOf", "target": "HumanLifeCycleStage" } ] }
0
{ "document": "adolescent stage Mature stage that refers to an adolescent who is over 13 and under 19 years old. [{'predicate': 'PartOf', 'target': 'MatureStage'}, {'predicate': 'subClassOf', 'target': 'HumanLifeCycleStage'}]" }
{ "aliases": null, "definition": "Calcification within the adrenal glands.", "id": "AdrenalCalcification", "label": "Adrenal calcification", "logical_definition": null, "original_id": "HP:0010512", "relationships": [ { "predicate": "subClassOf", "target": "EctopicCalcification" }, { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenal calcification Calcification within the adrenal glands. [{'predicate': 'subClassOf', 'target': 'EctopicCalcification'}, {'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone.", "id": "AdrenalCortex", "label": "adrenal cortex", "logical_definition": null, "original_id": "UBERON:0001235", "relationships": [ { "predicate": "PartOf", "target": "AdrenalGland" }, { "predicate": "DevelopsFrom", "target": "Mesoderm" }, { "predicate": "CapableOf", "target": "GlucocorticoidBiosyntheticProcess" }, { "predicate": "CapableOf", "target": "MineralocorticoidBiosyntheticProcess" }, { "predicate": "CapableOf", "target": "AldosteroneSecretion" }, { "predicate": "ContributesToMorphologyOf", "target": "AdrenalGland" }, { "predicate": "subClassOf", "target": "Cortex" } ] }
0
{ "document": "adrenal cortex The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone. [{'predicate': 'PartOf', 'target': 'AdrenalGland'}, {'predicate': 'DevelopsFrom', 'target': 'Mesoderm'}, {'predicate': 'CapableOf', 'target': 'GlucocorticoidBiosyntheticProcess'}, {'predicate': 'CapableOf', 'target': 'MineralocorticoidBiosyntheticProcess'}, {'predicate': 'CapableOf', 'target': 'AldosteroneSecretion'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'AdrenalGland'}, {'predicate': 'subClassOf', 'target': 'Cortex'}]" }
{ "aliases": null, "definition": "A chromaffin cell that is part of the adrenal cortex.", "id": "AdrenalCortexChromaffinCell", "label": "adrenal cortex chromaffin cell", "logical_definition": null, "original_id": "CL:1000427", "relationships": [ { "predicate": "subClassOf", "target": "ChromaffinCell" } ] }
0
{ "document": "adrenal cortex chromaffin cell A chromaffin cell that is part of the adrenal cortex. [{'predicate': 'subClassOf', 'target': 'ChromaffinCell'}]" }
{ "aliases": null, "definition": "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].", "id": "AdrenalGland", "label": "adrenal gland", "logical_definition": null, "original_id": "UBERON:0002369", "relationships": [ { "predicate": "PartOf", "target": "Abdomen" }, { "predicate": "PartOf", "target": "EndocrineSystem" }, { "predicate": "InLateralSideOf", "target": "EndocrineSystem" }, { "predicate": "HasDevelopmentalContributionFrom", "target": "Mesoderm" }, { "predicate": "HasDevelopmentalContributionFrom", "target": "NeuralCrest" }, { "predicate": "subClassOf", "target": "AdrenalInterrenalGland" } ] }
0
{ "document": "adrenal gland Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]. [{'predicate': 'PartOf', 'target': 'Abdomen'}, {'predicate': 'PartOf', 'target': 'EndocrineSystem'}, {'predicate': 'InLateralSideOf', 'target': 'EndocrineSystem'}, {'predicate': 'HasDevelopmentalContributionFrom', 'target': 'Mesoderm'}, {'predicate': 'HasDevelopmentalContributionFrom', 'target': 'NeuralCrest'}, {'predicate': 'subClassOf', 'target': 'AdrenalInterrenalGland'}]" }
{ "aliases": null, "definition": "Absent development of the adrenal gland.", "id": "AdrenalGlandAgenesis", "label": "Adrenal gland agenesis", "logical_definition": null, "original_id": "HP:0011743", "relationships": [ { "predicate": "subClassOf", "target": "AdrenalGlandDysgenesis" } ] }
0
{ "document": "Adrenal gland agenesis Absent development of the adrenal gland. [{'predicate': 'subClassOf', 'target': 'AdrenalGlandDysgenesis'}]" }
{ "aliases": null, "definition": "The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex.", "id": "AdrenalGlandCapsule", "label": "adrenal gland capsule", "logical_definition": null, "original_id": "UBERON:0002052", "relationships": [ { "predicate": "ContributesToMorphologyOf", "target": "AdrenalCortex" }, { "predicate": "ComposedPrimarilyOf", "target": "DenseIrregularConnectiveTissue" } ] }
0
{ "document": "adrenal gland capsule The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex. [{'predicate': 'ContributesToMorphologyOf', 'target': 'AdrenalCortex'}, {'predicate': 'ComposedPrimarilyOf', 'target': 'DenseIrregularConnectiveTissue'}]" }
{ "aliases": null, "definition": "Abnormal development of the adrenal gland.", "id": "AdrenalGlandDysgenesis", "label": "Adrenal gland dysgenesis", "logical_definition": null, "original_id": "HP:0008216", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenal gland dysgenesis Abnormal development of the adrenal gland. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens.", "id": "AdrenalGlandGlandularCell", "label": "adrenal gland glandular cell", "logical_definition": null, "original_id": "CL:1001601", "relationships": null }
0
{ "document": "adrenal gland glandular cell Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens. None" }
{ "aliases": null, "definition": "Enlargement of the adrenal gland.", "id": "AdrenalHyperplasia", "label": "Adrenal hyperplasia", "logical_definition": null, "original_id": "HP:0008221", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenal hyperplasia Enlargement of the adrenal gland. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "Developmental hypoplasia of the adrenal glands.", "id": "AdrenalHypoplasia", "label": "Adrenal hypoplasia", "logical_definition": null, "original_id": "HP:0000835", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenal hypoplasia Developmental hypoplasia of the adrenal glands. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.", "id": "AdrenalInsufficiency", "label": "Adrenal insufficiency", "logical_definition": null, "original_id": "HP:0000846", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalPhysiology" } ] }
0
{ "document": "Adrenal insufficiency Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalPhysiology'}]" }
{ "aliases": null, "definition": "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO].", "id": "AdrenalInterrenalGland", "label": "adrenal/interrenal gland", "logical_definition": null, "original_id": "UBERON:0006858", "relationships": [ { "predicate": "PartOf", "target": "ChromaffinSystem" }, { "predicate": "HasPart", "target": "ChromaffinCell" }, { "predicate": "HasPart", "target": "BiogenicAmineSecretingCell" }, { "predicate": "DevelopsFrom", "target": "IntermediateMesoderm" }, { "predicate": "subClassOf", "target": "EndocrineGland" } ] }
0
{ "document": "adrenal/interrenal gland This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]. [{'predicate': 'PartOf', 'target': 'ChromaffinSystem'}, {'predicate': 'HasPart', 'target': 'ChromaffinCell'}, {'predicate': 'HasPart', 'target': 'BiogenicAmineSecretingCell'}, {'predicate': 'DevelopsFrom', 'target': 'IntermediateMesoderm'}, {'predicate': 'subClassOf', 'target': 'EndocrineGland'}]" }
{ "aliases": null, "definition": "Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries", "id": "AdrenalLeiomyoma", "label": "Adrenal leiomyoma", "logical_definition": null, "original_id": "HP:0034549", "relationships": [ { "predicate": "subClassOf", "target": "NeoplasmOfTheAdrenalGland" } ] }
0
{ "document": "Adrenal leiomyoma Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries [{'predicate': 'subClassOf', 'target': 'NeoplasmOfTheAdrenalGland'}]" }
{ "aliases": null, "definition": "The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine.", "id": "AdrenalMedulla", "label": "adrenal medulla", "logical_definition": null, "original_id": "UBERON:0001236", "relationships": [ { "predicate": "HasPart", "target": "TypeIICellOfAdrenalMedulla" }, { "predicate": "HasPart", "target": "TypeICellOfAdrenalMedulla" }, { "predicate": "HasPart", "target": "ChromaffinCellOfAdrenalGland" }, { "predicate": "DevelopsFrom", "target": "NeuralCrest" }, { "predicate": "SurroundedBy", "target": "AdrenalCortex" }, { "predicate": "ContributesToMorphologyOf", "target": "AdrenalGland" }, { "predicate": "subClassOf", "target": "MedullaOfOrgan" } ] }
0
{ "document": "adrenal medulla The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine. [{'predicate': 'HasPart', 'target': 'TypeIICellOfAdrenalMedulla'}, {'predicate': 'HasPart', 'target': 'TypeICellOfAdrenalMedulla'}, {'predicate': 'HasPart', 'target': 'ChromaffinCellOfAdrenalGland'}, {'predicate': 'DevelopsFrom', 'target': 'NeuralCrest'}, {'predicate': 'SurroundedBy', 'target': 'AdrenalCortex'}, {'predicate': 'ContributesToMorphologyOf', 'target': 'AdrenalGland'}, {'predicate': 'subClassOf', 'target': 'MedullaOfOrgan'}]" }
{ "aliases": null, "definition": "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation.", "id": "AdrenalMedullaChromaffinCell", "label": "adrenal medulla chromaffin cell", "logical_definition": null, "original_id": "CL:0000336", "relationships": [ { "predicate": "DevelopsFrom", "target": "MigratoryTrunkNeuralCrestCell" }, { "predicate": "subClassOf", "target": "GlandularEpithelialCell" }, { "predicate": "subClassOf", "target": "ChromaffinCell" }, { "predicate": "subClassOf", "target": "BiogenicAmineSecretingCell" } ] }
0
{ "document": "adrenal medulla chromaffin cell A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation. [{'predicate': 'DevelopsFrom', 'target': 'MigratoryTrunkNeuralCrestCell'}, {'predicate': 'subClassOf', 'target': 'GlandularEpithelialCell'}, {'predicate': 'subClassOf', 'target': 'ChromaffinCell'}, {'predicate': 'subClassOf', 'target': 'BiogenicAmineSecretingCell'}]" }
{ "aliases": null, "definition": "Developmental hypoplasia of the adrenal medulla.", "id": "AdrenalMedullaryHypoplasia", "label": "Adrenal medullary hypoplasia", "logical_definition": null, "original_id": "HP:0008239", "relationships": [ { "predicate": "subClassOf", "target": "AdrenalHypoplasia" } ] }
0
{ "document": "Adrenal medullary hypoplasia Developmental hypoplasia of the adrenal medulla. [{'predicate': 'subClassOf', 'target': 'AdrenalHypoplasia'}]" }
{ "aliases": null, "definition": null, "id": "AdrenalOveractivity", "label": "Adrenal overactivity", "logical_definition": null, "original_id": "HP:0002717", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalPhysiology" } ] }
0
{ "document": "Adrenal overactivity None [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalPhysiology'}]" }
{ "aliases": null, "definition": "Pheochromocytoma originating from the adrenal medulla.", "id": "AdrenalPheochromocytoma", "label": "Adrenal pheochromocytoma", "logical_definition": null, "original_id": "HP:0006748", "relationships": [ { "predicate": "subClassOf", "target": "Pheochromocytoma" }, { "predicate": "subClassOf", "target": "NeoplasmOfTheAdrenalMedulla" } ] }
0
{ "document": "Adrenal pheochromocytoma Pheochromocytoma originating from the adrenal medulla. [{'predicate': 'subClassOf', 'target': 'Pheochromocytoma'}, {'predicate': 'subClassOf', 'target': 'NeoplasmOfTheAdrenalMedulla'}]" }
{ "aliases": null, "definition": "Tissue that is part of some adrenal gland.", "id": "AdrenalTissue", "label": "adrenal tissue", "logical_definition": null, "original_id": "UBERON:0018303", "relationships": null }
0
{ "document": "adrenal tissue Tissue that is part of some adrenal gland. None" }
{ "aliases": null, "definition": "Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.", "id": "AdrenalXanthomatosis", "label": "Adrenal xanthomatosis", "logical_definition": null, "original_id": "HP:0034622", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenal xanthomatosis Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "A racemate comprising equimolar amounts of (R)-adrenaline and (S)-adrenaline.", "id": "Adrenaline", "label": "adrenaline", "logical_definition": null, "original_id": "CHEBI:33568", "relationships": [ { "predicate": "HasPart", "target": "_R_adrenaline" }, { "predicate": "HasPart", "target": "_S_adrenaline" }, { "predicate": "HasRole", "target": "HumanMetabolite" }, { "predicate": "subClassOf", "target": "Racemate" } ] }
0
{ "document": "adrenaline A racemate comprising equimolar amounts of (R)-adrenaline and (S)-adrenaline. [{'predicate': 'HasPart', 'target': '_R_adrenaline'}, {'predicate': 'HasPart', 'target': '_S_adrenaline'}, {'predicate': 'HasRole', 'target': 'HumanMetabolite'}, {'predicate': 'subClassOf', 'target': 'Racemate'}]" }
{ "aliases": null, "definition": "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.", "id": "AdrenergicAgent", "label": "adrenergic agent", "logical_definition": null, "original_id": "CHEBI:37962", "relationships": [ { "predicate": "subClassOf", "target": "NeurotransmitterAgent" } ] }
0
{ "document": "adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. [{'predicate': 'subClassOf', 'target': 'NeurotransmitterAgent'}]" }
{ "aliases": null, "definition": "An agent that selectively binds to and activates adrenergic receptors.", "id": "AdrenergicAgonist", "label": "adrenergic agonist", "logical_definition": null, "original_id": "CHEBI:37886", "relationships": [ { "predicate": "subClassOf", "target": "AdrenergicAgent" } ] }
0
{ "document": "adrenergic agonist An agent that selectively binds to and activates adrenergic receptors. [{'predicate': 'subClassOf', 'target': 'AdrenergicAgent'}]" }
{ "aliases": null, "definition": null, "id": "AdrenocorticalAbnormality", "label": "Adrenocortical abnormality", "logical_definition": null, "original_id": "HP:0000849", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenocortical abnormality None [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": "Adrenocortical adenomas are benign tumors of the adrenal cortex.", "id": "AdrenocorticalAdenoma", "label": "Adrenocortical adenoma", "logical_definition": null, "original_id": "HP:0008256", "relationships": [ { "predicate": "subClassOf", "target": "NeoplasmOfTheAdrenalCortex" } ] }
0
{ "document": "Adrenocortical adenoma Adrenocortical adenomas are benign tumors of the adrenal cortex. [{'predicate': 'subClassOf', 'target': 'NeoplasmOfTheAdrenalCortex'}]" }
{ "aliases": null, "definition": "A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone.", "id": "AdrenocorticalCarcinoma", "label": "Adrenocortical carcinoma", "logical_definition": null, "original_id": "HP:0006744", "relationships": [ { "predicate": "subClassOf", "target": "NeoplasmOfTheAdrenalCortex" } ] }
0
{ "document": "Adrenocortical carcinoma A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone. [{'predicate': 'subClassOf', 'target': 'NeoplasmOfTheAdrenalCortex'}]" }
{ "aliases": null, "definition": "The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex.", "id": "AdrenocorticalCytomegaly", "label": "Adrenocortical cytomegaly", "logical_definition": null, "original_id": "HP:0008186", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfAdrenalMorphology" } ] }
0
{ "document": "Adrenocortical cytomegaly The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfAdrenalMorphology'}]" }
{ "aliases": null, "definition": null, "id": "AdrenocorticalHypoplasia", "label": "Adrenocortical hypoplasia", "logical_definition": null, "original_id": "HP:0008182", "relationships": [ { "predicate": "subClassOf", "target": "AdrenocorticalAbnormality" } ] }
0
{ "document": "Adrenocortical hypoplasia None [{'predicate': 'subClassOf', 'target': 'AdrenocorticalAbnormality'}]" }
{ "aliases": null, "definition": "A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol.", "id": "AdrenocorticotropicHormoneDeficiency", "label": "Adrenocorticotropic hormone deficiency", "logical_definition": null, "original_id": "HP:0011748", "relationships": [ { "predicate": "subClassOf", "target": "AnteriorHypopituitarism" } ] }
0
{ "document": "Adrenocorticotropic hormone deficiency A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol. [{'predicate': 'subClassOf', 'target': 'AnteriorHypopituitarism'}]" }
{ "aliases": null, "definition": "Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex.", "id": "AdrenocorticotropicHormoneExcess", "label": "Adrenocorticotropic hormone excess", "logical_definition": null, "original_id": "HP:0011749", "relationships": [ { "predicate": "subClassOf", "target": "Hyperpituitarism" } ] }
0
{ "document": "Adrenocorticotropic hormone excess Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex. [{'predicate': 'subClassOf', 'target': 'Hyperpituitarism'}]" }
{ "aliases": null, "definition": "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin.", "id": "AdrenocorticotropicHormoneSecretingCell", "label": "adrenocorticotropic hormone secreting cell", "logical_definition": null, "original_id": "CL:0000467", "relationships": null }
0
{ "document": "adrenocorticotropic hormone secreting cell A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin. None" }
{ "aliases": null, "definition": "Adrenal insufficiency secondary to a defect in ACTH production.", "id": "AdrenocorticotropinDeficientAdrenalInsufficiency", "label": "Adrenocorticotropin deficient adrenal insufficiency", "logical_definition": null, "original_id": "HP:0011735", "relationships": [ { "predicate": "subClassOf", "target": "CentralAdrenalInsufficiency" } ] }
0
{ "document": "Adrenocorticotropin deficient adrenal insufficiency Adrenal insufficiency secondary to a defect in ACTH production. [{'predicate': 'subClassOf', 'target': 'CentralAdrenalInsufficiency'}]" }
{ "aliases": null, "definition": "Adrenal insufficiency secondary to a defect in the ACTH receptor.", "id": "AdrenocorticotropinReceptorDefect", "label": "Adrenocorticotropin receptor defect", "logical_definition": null, "original_id": "HP:0008259", "relationships": [ { "predicate": "subClassOf", "target": "CentralAdrenalInsufficiency" } ] }
0
{ "document": "Adrenocorticotropin receptor defect Adrenal insufficiency secondary to a defect in the ACTH receptor. [{'predicate': 'subClassOf', 'target': 'CentralAdrenalInsufficiency'}]" }
{ "aliases": null, "definition": "Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects.", "id": "AdrenogenitalSyndrome", "label": "Adrenogenital syndrome", "logical_definition": null, "original_id": "HP:0000840", "relationships": [ { "predicate": "subClassOf", "target": "PubertyAndGonadalDisorders" } ] }
0
{ "document": "Adrenogenital syndrome Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects. [{'predicate': 'subClassOf', 'target': 'PubertyAndGonadalDisorders'}]" }
{ "aliases": null, "definition": "Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.", "id": "AdultOnset", "label": "Adult onset", "logical_definition": null, "original_id": "HP:0003581", "relationships": [ { "predicate": "subClassOf", "target": "Onset" } ] }
0
{ "document": "Adult onset Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later. [{'predicate': 'subClassOf', 'target': 'Onset'}]" }
{ "aliases": null, "definition": "Inability to see well at night or in poor light with onset in adulthood.", "id": "AdultOnsetNightBlindness", "label": "Adult-onset night blindness", "logical_definition": null, "original_id": "HP:0007830", "relationships": [ { "predicate": "subClassOf", "target": "Nyctalopia" } ] }
0
{ "document": "Adult-onset night blindness Inability to see well at night or in poor light with onset in adulthood. [{'predicate': 'subClassOf', 'target': 'Nyctalopia'}]" }
{ "aliases": null, "definition": "The presence of sensorineural deafness with late onset.", "id": "AdultOnsetSensorineuralHearingImpairment", "label": "Adult onset sensorineural hearing impairment", "logical_definition": null, "original_id": "HP:0008615", "relationships": [ { "predicate": "subClassOf", "target": "SensorineuralHearingImpairment" } ] }
0
{ "document": "Adult onset sensorineural hearing impairment The presence of sensorineural deafness with late onset. [{'predicate': 'subClassOf', 'target': 'SensorineuralHearingImpairment'}]" }
{ "aliases": null, "definition": "A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage.", "id": "AdultOrganism", "label": "adult organism", "logical_definition": null, "original_id": "UBERON:0007023", "relationships": null }
0
{ "document": "adult organism A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage. None" }
{ "aliases": null, "definition": "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.", "id": "AdultSkeletalMuscleMyoblast", "label": "adult skeletal muscle myoblast", "logical_definition": null, "original_id": "CL:0008017", "relationships": [ { "predicate": "subClassOf", "target": "AnimalCell" } ] }
0
{ "document": "adult skeletal muscle myoblast A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. [{'predicate': 'subClassOf', 'target': 'AnimalCell'}]" }
{ "aliases": null, "definition": "Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age.", "id": "AdvancedEruptionOfTeeth", "label": "Advanced eruption of teeth", "logical_definition": null, "original_id": "HP:0006288", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfDentalEruption" } ] }
0
{ "document": "Advanced eruption of teeth Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfDentalEruption'}]" }
{ "aliases": null, "definition": "Ossification of carpal bones at an abnormally early age.", "id": "AdvancedOssificationOfCarpalBones", "label": "Advanced ossification of carpal bones", "logical_definition": null, "original_id": "HP:0004233", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfCarpalBoneOssification" } ] }
0
{ "document": "Advanced ossification of carpal bones Ossification of carpal bones at an abnormally early age. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfCarpalBoneOssification'}]" }
{ "aliases": null, "definition": "Ossification of hand bones at an earlier age than normal.", "id": "AdvancedOssificationOfTheHandBones", "label": "Advanced ossification of the hand bones", "logical_definition": null, "original_id": "HP:0004051", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalHandBoneOssification" } ] }
0
{ "document": "Advanced ossification of the hand bones Ossification of hand bones at an earlier age than normal. [{'predicate': 'subClassOf', 'target': 'AbnormalHandBoneOssification'}]" }
{ "aliases": null, "definition": "Ossification of the humeral epiphysis at an earlier age than normal.", "id": "AdvancedOssificationOfTheHumeralEpiphysis", "label": "Advanced ossification of the humeral epiphysis", "logical_definition": null, "original_id": "HP:0003893", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalityOfTheHumeralEpiphysis" }, { "predicate": "subClassOf", "target": "AbnormalEpiphysealOssification" } ] }
0
{ "document": "Advanced ossification of the humeral epiphysis Ossification of the humeral epiphysis at an earlier age than normal. [{'predicate': 'subClassOf', 'target': 'AbnormalityOfTheHumeralEpiphysis'}, {'predicate': 'subClassOf', 'target': 'AbnormalEpiphysealOssification'}]" }
{ "aliases": null, "definition": "A degree of pneumatization that is increased compared to age-related norms.", "id": "AdvancedPneumatizationOfCranialSinuses", "label": "Advanced pneumatization of cranial sinuses", "logical_definition": null, "original_id": "HP:0010540", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalParanasalSinusMorphology" } ] }
0
{ "document": "Advanced pneumatization of cranial sinuses A degree of pneumatization that is increased compared to age-related norms. [{'predicate': 'subClassOf', 'target': 'AbnormalParanasalSinusMorphology'}]" }
{ "aliases": null, "definition": "An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms.", "id": "AdvancedPneumatizationOfTheMastoidProcess", "label": "Advanced pneumatization of the mastoid process", "logical_definition": null, "original_id": "HP:0010724", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalMastoidMorphology" } ] }
0
{ "document": "Advanced pneumatization of the mastoid process An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms. [{'predicate': 'subClassOf', 'target': 'AbnormalMastoidMorphology'}]" }
{ "aliases": null, "definition": "A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity.", "id": "AdvancedScleroticLupusNephritis", "label": "Advanced sclerotic lupus nephritis", "logical_definition": null, "original_id": "HP:0033732", "relationships": [ { "predicate": "subClassOf", "target": "LupusNephritis" } ] }
0
{ "document": "Advanced sclerotic lupus nephritis A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity. [{'predicate': 'subClassOf', 'target': 'LupusNephritis'}]" }
{ "aliases": null, "definition": "Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.", "id": "AdvancedTarsalOssification", "label": "Advanced tarsal ossification", "logical_definition": null, "original_id": "HP:0008108", "relationships": [ { "predicate": "subClassOf", "target": "AbnormalTarsalOssification" } ] }
0
{ "document": "Advanced tarsal ossification Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones. [{'predicate': 'subClassOf', 'target': 'AbnormalTarsalOssification'}]" }
{ "aliases": null, "definition": "An outermost connective tissue covering of an organ, vessel, or other structure[WP].", "id": "Adventitia", "label": "adventitia", "logical_definition": null, "original_id": "UBERON:0005742", "relationships": [ { "predicate": "ComposedPrimarilyOf", "target": "ConnectiveTissue" }, { "predicate": "subClassOf", "target": "OrganComponentLayer" } ] }
0
{ "document": "adventitia An outermost connective tissue covering of an organ, vessel, or other structure[WP]. [{'predicate': 'ComposedPrimarilyOf', 'target': 'ConnectiveTissue'}, {'predicate': 'subClassOf', 'target': 'OrganComponentLayer'}]" }
{ "aliases": null, "definition": "An adventitia that is part of a vas deferens.", "id": "AdventitiaOfDuctusDeferens", "label": "adventitia of ductus deferens", "logical_definition": null, "original_id": "UBERON:0006647", "relationships": null }
0
{ "document": "adventitia of ductus deferens An adventitia that is part of a vas deferens. None" }
{ "aliases": null, "definition": "An adventitia that is part of a epididymis.", "id": "AdventitiaOfEpididymis", "label": "adventitia of epididymis", "logical_definition": null, "original_id": "UBERON:0006645", "relationships": null }
0
{ "document": "adventitia of epididymis An adventitia that is part of a epididymis. None" }
{ "aliases": null, "definition": "An adventitia that is part of a esophagus.", "id": "AdventitiaOfEsophagus", "label": "adventitia of esophagus", "logical_definition": null, "original_id": "UBERON:0012504", "relationships": null }
0
{ "document": "adventitia of esophagus An adventitia that is part of a esophagus. None" }
{ "aliases": null, "definition": "An adventitia that is part of a seminal vesicle.", "id": "AdventitiaOfSeminalVesicle", "label": "adventitia of seminal vesicle", "logical_definition": null, "original_id": "UBERON:0006648", "relationships": null }
0
{ "document": "adventitia of seminal vesicle An adventitia that is part of a seminal vesicle. None" }
{ "aliases": null, "definition": "An adventitia that is part of a ureter.", "id": "AdventitiaOfUreter", "label": "adventitia of ureter", "logical_definition": null, "original_id": "UBERON:0001252", "relationships": [ { "predicate": "PartOf", "target": "WallOfUreter" } ] }
0
{ "document": "adventitia of ureter An adventitia that is part of a ureter. [{'predicate': 'PartOf', 'target': 'WallOfUreter'}]" }
{ "aliases": null, "definition": "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc", "id": "AdventitialCell", "label": "adventitial cell", "logical_definition": null, "original_id": "CL:0002503", "relationships": [ { "predicate": "subClassOf", "target": "SupportingCell" }, { "predicate": "subClassOf", "target": "ConnectiveTissueCell" } ] }
0
{ "document": "adventitial cell A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc [{'predicate': 'subClassOf', 'target': 'SupportingCell'}, {'predicate': 'subClassOf', 'target': 'ConnectiveTissueCell'}]" }