bvand086/sciwritingdataset · Datasets at Hugging Face

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considered the use of histamine receptor antagonists, in
addition to high dose steroids, to address the edema in amore targeted manner given our concern for type I hyper-sensitivity
Second, the CMC product itself could have beeninvestigated more thoroughly, to identify an underlying eti-ology for the airway edema
We suggest that providersnotify their CMC supplier regarding the complication andverify that the CMC lot does not have any active recalls in
place.
Regardless of mechanism, otolaryngologists should be
aware of this rare, but life-threatening complication ofinjection laryngoplasty and counsel patients accordinglywhen obtaining consent
In patients with any concern forpost injection swelling, urgent evaluation with ﬂexible
nasopharyngoscopy should b e performed
If there are
signs and symptoms of airway edema, the patient should
be upgraded to the ICU for airway watch, intravenous
steroids, histamine receptor antagonists if type I hyper-
sensitivity is suspected, and possible intubation
patients
with a known sensitivity to CM C, alternativ e materials
may be considered, includi ng hyaluronic acid and cal-
cium hydroxyapatite.
CONCLUSIONS
This represents the ﬁrst reported case describing a local
reaction to carboxymethylcellulose following vocal foldinjection augmentation, leading to life-threatening laryngeal
edema, intubation, and eventual tracheostomy placement.While rare, based on the existing literature, it appears mostlikely that our patient had a type I hypersensitivity reactionto CM
C
Otolaryngologists should be aware of this poten-tial complication, council patients accordingly, and if a
reaction does occur, treat aggressively with intravenous ste-
roids, histamine antagonists, traditional airway supportivemeasures, and potential intubation.
REFERENCES
1
Sulica L, Rosen CA, Postma GN, et al
Current practice in injection
augmentation of the vocal folds: Indications, treatment principles,techniques, and complications
The Laryngoscope
2010;120:319 –325.
https://doi.org/10.1002/lary.20737 .
2
D i n - L o v i n e s c uC ,T a l m o rG ,G r a v i n aA ,e ta l .A d v e r s ee v e n t sf o l l o w i n g
injection laryngoplasty: an analysis of the MAUDE database
Am J Oto-
laryngol
2021;42: 103092
https://doi.org/10.1016 /j.amjoto.2021.103092 .
3
MAUDE adverse event report: CYTOPHIL, INC
REN /C19U GEL,
1.5CC SYSTEM, VOCAL CORD MEDIALIZATION
Publishedonline April 26, 2018
https://www.accessdata.fda.gov/scripts/cdrh/
cfdocs/cfMAUDE/detail.cfm?mdrfoi__id=7366257&pc=MIX .
4
Maude adverse event report: merz north america, inc
Prolaryn gel injectable
implant
Published online July 6, 2016
https://www.accessdata.fda.gov/
scripts/cdrh/cfdocs/cfMAUDE/deta il.cfm?mdrfoi__id=5728789&pc=MIX .
5
Hollabaugh CB, Burt LH, Walsh AP
Carboxymethylcellulose
Uses
and applications
Ind Eng Chem
1945;37:943 –947
https://doi.org/
10.1021/ie50430a015 .
6
Hotta E, Tamagawa-Mineoka R, Onishi Y, et al
Immediate hypersen-
sitivity reaction to carboxymethylcellulose in lidocaine jelly and dime-
thicone drops: a case report and mini-review
J Cutan Immunol
Allergy
2022;5:217 –221.https://doi.org/10.1002/cia2.12261 .
7
Mori S, Muroi N, Ono S, et al
Analysis of sensitization to carboxy-
methylcellulose: identi ﬁcation of high risk group using ELISA and his-
tamine release experiment
Inﬂamm Res Off J Eur Histamine Res Soc
Al
2004;53:164 –169.https://doi.org/10.1007/s00011-003-1238-9 .
8
Ohnishi A, Hashimoto K, Ozono E, et al
Anaphylaxis to carboxy-
methylcellulose: add food additives to the list of elicitors
Pediatrics .
2019;143: e20181180
https://doi.org/10.1542/peds.2018-1180 .
9
Brockow K, Bauerdorf F, Kugler C, et al
Idiopathic ”anaphylaxis
caused by carboxymethylcellulose in ice cream
J Allergy Clin Immunol
Pract
2021;9:555 –557.e1
https://doi.org/10.1016/j.jaip.2020.10.051 .
10
Elghouche AN, Nwosu OI, Jones AJ, et al
In ﬂammatory reactions to
laryngeal injection of hyaluronic acid derivatives
J Voice Off J Voice

considered the use of histamine receptor antagonists, in

addition to high dose steroids, to address the edema in amore targeted manner given our concern for type I hyper-sensitivity

Second, the CMC product itself could have beeninvestigated more thoroughly, to identify an underlying eti-ology for the airway edema

We suggest that providersnotify their CMC supplier regarding the complication andverify that the CMC lot does not have any active recalls in

place.

Regardless of mechanism, otolaryngologists should be

aware of this rare, but life-threatening complication ofinjection laryngoplasty and counsel patients accordinglywhen obtaining consent

In patients with any concern forpost injection swelling, urgent evaluation with ﬂexible

nasopharyngoscopy should b e performed

If there are

signs and symptoms of airway edema, the patient should

be upgraded to the ICU for airway watch, intravenous

steroids, histamine receptor antagonists if type I hyper-

sensitivity is suspected, and possible intubation

patients

with a known sensitivity to CM C, alternativ e materials

may be considered, includi ng hyaluronic acid and cal-

cium hydroxyapatite.

CONCLUSIONS

This represents the ﬁrst reported case describing a local

reaction to carboxymethylcellulose following vocal foldinjection augmentation, leading to life-threatening laryngeal

edema, intubation, and eventual tracheostomy placement.While rare, based on the existing literature, it appears mostlikely that our patient had a type I hypersensitivity reactionto CM

C

Otolaryngologists should be aware of this poten-tial complication, council patients accordingly, and if a

reaction does occur, treat aggressively with intravenous ste-

roids, histamine antagonists, traditional airway supportivemeasures, and potential intubation.

REFERENCES

1

Sulica L, Rosen CA, Postma GN, et al

Current practice in injection

augmentation of the vocal folds: Indications, treatment principles,techniques, and complications

The Laryngoscope

2010;120:319 –325.

https://doi.org/10.1002/lary.20737 .

2

D i n - L o v i n e s c uC ,T a l m o rG ,G r a v i n aA ,e ta l .A d v e r s ee v e n t sf o l l o w i n g

injection laryngoplasty: an analysis of the MAUDE database

Am J Oto-

laryngol

2021;42: 103092

https://doi.org/10.1016 /j.amjoto.2021.103092 .

3

MAUDE adverse event report: CYTOPHIL, INC

REN /C19U GEL,

1.5CC SYSTEM, VOCAL CORD MEDIALIZATION

Publishedonline April 26, 2018

https://www.accessdata.fda.gov/scripts/cdrh/

cfdocs/cfMAUDE/detail.cfm?mdrfoi__id=7366257&pc=MIX .

4

Maude adverse event report: merz north america, inc

Prolaryn gel injectable

implant

Published online July 6, 2016

https://www.accessdata.fda.gov/

scripts/cdrh/cfdocs/cfMAUDE/deta il.cfm?mdrfoi__id=5728789&pc=MIX .

5

Hollabaugh CB, Burt LH, Walsh AP

Carboxymethylcellulose

Uses

and applications

Ind Eng Chem

1945;37:943 –947

https://doi.org/

10.1021/ie50430a015 .

6

Hotta E, Tamagawa-Mineoka R, Onishi Y, et al

Immediate hypersen-

sitivity reaction to carboxymethylcellulose in lidocaine jelly and dime-

thicone drops: a case report and mini-review

J Cutan Immunol

Allergy

2022;5:217 –221.https://doi.org/10.1002/cia2.12261 .

7

Mori S, Muroi N, Ono S, et al

Analysis of sensitization to carboxy-

methylcellulose: identi ﬁcation of high risk group using ELISA and his-

tamine release experiment

Inﬂamm Res Off J Eur Histamine Res Soc

Al

2004;53:164 –169.https://doi.org/10.1007/s00011-003-1238-9 .

8

Ohnishi A, Hashimoto K, Ozono E, et al

Anaphylaxis to carboxy-

methylcellulose: add food additives to the list of elicitors

Pediatrics .

2019;143: e20181180

https://doi.org/10.1542/peds.2018-1180 .

9

Brockow K, Bauerdorf F, Kugler C, et al

Idiopathic ”anaphylaxis

caused by carboxymethylcellulose in ice cream

J Allergy Clin Immunol

Pract

2021;9:555 –557.e1

https://doi.org/10.1016/j.jaip.2020.10.051 .

10

Elghouche AN, Nwosu OI, Jones AJ, et al

In ﬂammatory reactions to

laryngeal injection of hyaluronic acid derivatives

J Voice Off J Voice