chaseharmon/MIT_Course_Catalog · Datasets at Hugging Face

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ES.112	Philosophy of Love	Explores the nature of love through works of philosophy, literature, film, poetry, and individual experience. Investigates the distinction among eros (desiring or appreciative love), philia (mutuality), and agape (love as pure giving). Students discuss ideas of love as a feeling, an action, a species of 'knowing someone,' or a way to give or take. Authors include Plato, Kant, Buber, D. H. Lawrence, Rumi, and Aristotle. Preference to students in ESG and Concourse.	true	Spring	Undergraduate	4-0-8	null	null	false	false	false	False	Humanities	CI-H
ES.113	Ancient Greek Philosophy and Mathematics	Explores the relationship between ancient Greek philosophy and mathematics. Investigates how ideas of definition, reason, argument and proof, rationality/irrationality, number, quality and quantity, truth, and even the idea of an idea were shaped by the interplay of philosophic and mathematical inquiry. Examines how discovery of the incommensurability of magnitudes challenged the Greek presumption that the cosmos is fully understandable. Explores the influence of mathematics on ancient Greek ethical theories. Authors: Euclid, Plato, Aristotle, Nicomachus, Theon of Smyrna, Bacon, Descartes, Dedekind, and Newton. Preference to students in Concourse and ESG.	true	Spring	Undergraduate	3-0-9	null	null	false	false	false	False	Humanities	CI-H
ES.114	Non-violence as a Way of Life	Addresses the philosophical question of what a non-violent life entails. Investigates its ethical dimensions and challenges, and considers whether we can derive a comprehensive moral theory from the principle of non-violence. Discusses the issues of lying, the duty to forgive, non-violent communication, the ethics of our relationship to anger, the possibility of loving enemies, and the ethics of punishment and rehabilitation. Includes readings from primary exponents of non-violence, such as Tolstoy, Gandhi and King.	true	Fall	Undergraduate	3-0-9	null	null	false	false	false	False	Humanities	CI-H
ES.9112	Philosophy of Love - MIT Prison Initiative	Explores the nature of love through works of philosophy, literature, film, poetry, and individual experience. Investigates the distinction among eros (desiring or appreciative love), philia (mutuality), and agape (love as pure giving). Students discuss ideas of love as a feeling, an action, a species of 'knowing someone,' or a way to give or take. Authors include Plato, Kant, Buber, D. H. Lawrence, Rumi, and Aristotle. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 10.	true	Spring	Undergraduate	3-0-9	null	null	false	false	false	False	Humanities	CI-H
ES.9114	Non-violence as a Way of Life - MIT Prison Initiative	Addresses the philosophical question of what a non-violent life entails. Investigates its ethical dimensions and challenges, and considers whether we can derive a comprehensive moral theory from the principle of non-violence. Discusses the issues of lying, the duty to forgive, non-violent communication, the ethics of our relationship to anger, the possibility of loving enemies, and the ethics of punishment and rehabilitation. Includes readings from primary exponents of non-violence, such as Tolstoy, Gandhi and King. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 10.	true	Fall	Undergraduate	3-0-9	null	null	false	false	false	False	Humanities	CI-H
ES.92	Authenticity - MIT Prison Initiative	Explores the question of how to live an authentic life, through works of western and eastern philosophy and contemporary psychology. Topics include emotions, anger, honesty, forgiveness, non-violent communication, conflict resolution, kindness and cruelty and compassion. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 12.	true	Fall, Spring	Undergraduate	3-0-3 [P/D/F]	null	null	false	false	false	False	False	False
ES.010	Chemistry of Sports: Understanding How Exercise Affects Your Body	Students apply chemistry knowledge to physical fitness through the study of three sports: swimming, cycling, and running. Classroom component focuses on nutrition, exercise, anatomy, physiology, and the chemistry of supplements and sports equipment. Laboratory component focuses on training for and completion of triathlon competition. Students may earn up to 2 PE points during the term by attending supervised triathlon training workouts. Preference to students in ESG.	true	Spring	Undergraduate	2-1-3 [P/D/F]	null	null	false	false	false	False	False	False
ES.011	Kitchen Chemistry	An experimental and "hands-on" approach to applied chemistry in cooking. Students perform experiments to illustrate chemical principles, such as extraction, denaturation, and phase changes. Preference to students in ESG.	true	Spring	Undergraduate	2-1-3 [P/D/F]	null	null	false	false	false	False	False	False
ES.100	An Introduction to Maker Skills	Introduction to making and use of MIT's maker spaces intended to build skills needed for designing, conducting, and completing experiments and design projects, such as may be encountered in undergraduate classwork and research activities. Includes maker space training (i.e., wood shop, digital fabrication, and electronics fabrication) and open-ended design projects, with work evenly divided between class, homework, and maker space activities. Limited to 12 by makerspace training and scheduling; priority given to ESG students.	true	Spring	Undergraduate	1-1-1 [P/D/F]	null	null	false	false	false	False	False	False
ES.200	ESG Undergraduate Teaching	An opportunity to assist in the teaching of subjects in ESG in biology, chemistry, humanities and social sciences, mathematics, and physics. Student instructors may be involved in grading, running problemsolving sessions, or teaching classes depending on experience and interest. Qualified students may also develop and teach undergraduate seminars under the supervision of an appropriate faculty or staff member. Student instructors meet weekly with staff to discuss their teaching and cover a variety of topics related to effective teaching techniques. Limited to students in ESG.	true	Fall	Undergraduate	2-0-4 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
ES.201	ESG Undergraduate Teaching	An opportunity to assist in the teaching of subjects in ESG in biology, chemistry, humanities and social sciences, mathematics, and physics. Student instructors may be involved in grading, running problem solving sessions, or teaching classes depending on experience and interest. Qualified students may also develop and teach undergraduate seminars under the supervision of an appropriate faculty or staff member. Student instructors meet every other week with staff to discuss their teaching and cover a variety of topics related to effective teaching techniques. Limited to students in ESG.	true	Spring	Undergraduate	1-0-2 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
ES.210	ESG Independent Study	Opportunity for independent study under regular supervision by a staff member. Projects require prior approval, as well as a written proposal and a final report. Limited to students in ESG.	true	Fall, IAP, Spring, Summer	Undergraduate	rranged [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
ES.UR	Undergraduate Research in ESG	For students wishing to pursue undergraduate research opportunities in the Experimental Study Group. Limited to students in ESG.	true	Fall, IAP, Spring, Summer	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S10	Special Seminar in Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S11	Special Seminar in Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring, Fall, IAP, Spring, Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S20	Special Seminar in Mathematics	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	IAP	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S21	Special Seminar in Mathematics	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, IAP, Spring, Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S30	Special Seminar in Engineering and Computer Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S31	Special Seminar in Engineering and Computer Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S40	Special Seminar in the Humanities	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S41	Special Seminar in the Humanities	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, Spring, Fall, IAP, Spring, Spring, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
ES.S42	Special Seminar in the Humanities	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, Spring	Undergraduate	rranged	null	null	false	false	false	False	False	False
ES.S50	Special Seminar in the Arts	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S51	Special Seminar in the Arts	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, IAP, Spring, Spring, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S60	Special Seminar in Social Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S601	Special Topics in Computer Science	Covers topics not included in the permanent curriculum. Limited to 10. Preference given to ESG students.	true	Fall	Undergraduate	rranged	null	null	false	false	false	False	False	False
ES.S602	Special Topics in Computer Science	Covers topics not included in the permanent curriculum. Preference given to ESG students.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S61	Special Seminar in Social Science	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S70	Special Seminar in Interdisciplinary Studies	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Fall, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S71	Special Seminar in Interdisciplinary Studies	Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S90	Special Studies in the MIT Initiative for Teaching Incarcerated Individuals	Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S91	Special Studies in the MIT Initiative for Teaching Incarcerated Individuals	Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S92	Special Studies in the MIT Initiative for Teaching Incarcerated Individuals	Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.	true	Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
ES.S93	Special Studies in the MIT Initiative for Teaching Incarcerated Individuals (New)	Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.	true	Fall, Spring	Undergraduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
HST.010	Human Functional Anatomy	Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body and present evolving knowledge of genes responsible for normal and abnormal anatomy. Lecturers focus on current problems in organ system research. Only HST students may register under HST.010, graded P/D/F. Lab fee.	true	Fall	Graduate	3-11-10 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.011	Human Functional Anatomy	Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body and present evolving knowledge of genes responsible for normal and abnormal anatomy. Lecturers focus on current problems in organ system research. Only HST students may register under HST.010, graded P/D/F. Lab fee. Enrollment restricted to graduate students.	true	Fall	Graduate	3-11-10	Permission of instructor	null	false	false	false	False	False	False
HST.015	MATLAB for Medicine	Practical introduction to use of quantitative methods in medicine and health research. Each session covers a different topic in quantitative techniques, provides an application to medicine, and includes a modeling activity using MATLAB. Students also complete problem sets. Restricted to first year HST MD students.	true	Summer	Graduate	2-0-4 [P/D/F]	null	null	false	false	false	False	False	False
HST.016	Artificial Intelligence in Health Care I (New)	Introduces fundamental concepts at the core of artificial intelligence (AI), as applied to health care problems. Didactic lectures, problem sets, and review/analyses of seminal papers in the field. Specific topics include: deep learning for clinical risk stratification, explaining complex machine learning models, bias and fairness in clinical machine learning, large language models, and Generative Pretrained Transformers (GPT models). No background in AI or machine learning is required. Only HST students may register under HST.016, which is graded P/D/F. Enrollment limited.	true	Summer	Graduate	2-0-4 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.017	Artificial Intelligence in Health Care I (New)	Introduces fundamental concepts at the core of artificial intelligence (AI), as applied to health care problems. Didactic lectures, problem sets, and review/analyses of seminal papers in the field. Specific topics include: deep learning for clinical risk stratification, explaining complex machine learning models, bias and fairness in clinical machine learning, large language models, and Generative Pretrained Transformers (GPT models). No background in AI or machine learning is required. Only HST students may register under HST.016, which is graded P/D/F. Enrollment limited.	true	Summer	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
HST.018	Artificial Intelligence in Health Care II (New)	Builds upon on the core concepts covered in HST.017. Student selected projects explore specific clinical problems. Student groups are paired with machine learning experts who provide guidance. Only HST students may register under HST.018, which is graded P/D/F.	true	IAP	Graduate	2-0-4 [P/D/F]	(HST.016 or HST.017) and permission of instructor	null	false	false	false	False	False	False
HST.019	Artificial Intelligence in Health Care II (New)	Builds upon on the core concepts covered in HST.017. Student selected projects explore specific clinical problems. Student groups are paired with machine learning experts who provide guidance. Only HST students may register under HST.018, which is graded P/D/F.	true	IAP	Graduate	2-0-4	(HST.016 or HST.017) and permission of instructor	null	false	false	false	False	False	False
HST.020	Musculoskeletal Pathophysiology	Growth and development of normal bone and joints, the biophysics and biomechanics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements. Only HST students may register under HST.020, graded P/D/F. Enrollment limited; restricted to medical and graduate students.	true	Spring	Graduate	3-0-3 [P/D/F]	HST.030 and HST.160	null	false	false	false	False	False	False
HST.021	Musculoskeletal Pathophysiology	Growth and development of normal bone and joints, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements. Only HST students may register under HST.020, graded P/D/F. Enrollment limited; restricted to medical and graduate students.	true	Spring	Graduate	3-0-3	HST.030 and HST.160	null	false	false	false	False	False	False
HST.030	Human Pathology	Introduction to the functional structure of normal cells and tissues; pathologic principles of cellular adaptation and injury, inflammation, circulatory disorders, immunologic injury, infection, genetic disorders, and neoplasia in humans. Lectures, conferences emphasizing clinical correlations and contemporary experimental biology, laboratories with examination of microscopic and gross specimens, and autopsy case studies emphasizing modern pathology practice. Only HST students may register under HST.030, graded P/D/F. Lab fee. Limited to 60; priority to HST students.	true	Fall	Graduate	4-3-8 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.031	Human Pathology	Introduction to the functional structure of normal cells and tissues, pathologic principles of cellular adaptation and injury, inflammation, circulatory disorders, immunologic injury, infection, genetic disorders, and neoplasia in humans. Lectures, conferences emphasizing clinical correlations and contemporary experimental biology. Laboratories with examination of microscopic and gross specimens, and autopsy case studies emphasizing modern pathology practice. Only HST students may register under HST.030, graded P/D/F. Lab fee. Enrollment limited.	true	Fall	Graduate	4-3-8	Biology (GIR), Physics I (GIR), and permission of instructor	null	false	false	false	False	False	False
HST.041	Mechanisms of Microbial Pathogenesis	Deals with the mechanisms of pathogenesis of bacteria, viruses, and other microorganisms. Approach spans mechanisms from molecular to clinical aspects of disease. Topics selected for intrinsic interest and cover the demonstrated spectrum of pathophysiologic mechanisms. Only HST students may register under HST.040, graded P/D/F. Lab fee. Enrollment limited.	true	Fall	Graduate	4-2-6	Biology (GIR), 7.05, and permission of instructor	null	false	false	false	False	False	False
HST.060	Endocrinology	Physiology and pathophysiology of the human endocrine system. Three hours of lecture and section each week concern individual parts of the endocrine system. Topics also include assay techniques, physiological integration, etc. At frequent clinic sessions, patients are presented who demonstrate clinical problems considered in the didactic lectures. Enrollment limited.	true	Spring	Graduate	3-0-6 [P/D/F]	Biology (GIR), 7.05, and permission of instructor	null	false	false	false	False	False	False
HST.061	Endocrinology	Physiology and pathophysiology of the human endocrine system. Three hours of lecture and section each week concern individual parts of the endocrine system. Topics include assay techniques, physiological integration, etc. At frequent clinic sessions, patients are presented who demonstrate clinical problems considered in the didactic lectures. Only HST students may register under HST.060, graded P/D/F. Enrollment limited.	true	Spring	Graduate	3-0-6	Biology (GIR), 7.05, and permission of instructor	null	false	false	false	False	False	False
HST.071	Human Reproductive Biology	Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. Only HST students may register under HST.070, graded P/D/F.	true	Fall, Spring, Fall, Fall, IAP, Spring, Summer, IAP, Spring	Graduate	4-0-2	7.05 and permission of instructor	null	false	false	false	False	False	False
HST.081	Hematology	Intensive survey of the biology, physiology and pathophysiology of blood with systematic consideration of hematopoiesis, white blood cells, red blood cells, platelets, coagulation, plasma proteins, and hematologic malignancies. Emphasis given equally to didactic discussion and analysis of clinical problems. Enrollment limited.	true	Spring, Fall, Fall, IAP, Spring, Summer, IAP, Spring	Graduate	2-1-3	7.05 and permission of instructor	null	false	false	false	False	False	False
HST.090	Cardiovascular Pathophysiology	Normal and pathologic physiology of the heart and vascular system. Emphasis includes hemodynamics, electrophysiology, gross pathology, and clinical correlates of cardiovascular function in normal and in a variety of disease states. Special attention given to congenital, rheumatic, valvular heart disease and cardiomyopathy. Only HST students may register under HST.090, graded P/D/F.	true	Spring	Graduate	3-2-10 [P/D/F]	HST.030 or HST.031	null	false	false	false	False	False	False
HST.091	Cardiovascular Pathophysiology	Normal and pathologic physiology of the heart and vascular system. Emphasis includes hemodynamics, electrophysiology, gross pathology, and clinical correlates of cardiovascular function in normal and in a variety of disease states. Special attention given to congenital, rheumatic, valvular heart disease and cardiomyopathy. Only HST students may register under HST.090, graded P/D/F. Enrollment limited.	true	Spring	Graduate	3-2-10	(HST.030 or HST.031) and permission of instructor	null	false	false	false	False	False	False
HST.100	Respiratory Pathophysiology	Lectures, seminars, and laboratories cover the histology, cell biology, and physiological function of the lung with multiple examples related to common diseases of the lung. A quantitative approach to the physics of gases, respiratory mechanics, and gas exchange is provided to explain pathological mechanisms. Use of medical ventilators is discussed in lecture and in laboratory experiences. For MD candidates and other students with background in science. Only HST students may register under HST.100, graded P/D/F.	true	Spring	Graduate	4-0-8 [P/D/F]	Physics I (GIR) and 7.05	null	false	false	false	False	False	False
HST.101	Respiratory Pathophysiology	Lectures, seminars, and laboratories cover the histology, cell biology, and physiological function of the lung with multiple examples related to common diseases of the lung. A quantitative approach to the physics of gases, respiratory mechanics, and gas exchange is provided to explain pathological mechanisms. Use of medical ventilators is discussed in lecture and in laboratory experiences. For MD candidates and other students with background in science. Only HST students may register under HST.100, graded P/D/F. Enrollment limited.	true	Spring	Graduate	4-0-8	Physics I (GIR), 7.05, and permission of instructor	null	false	false	false	False	False	False
HST.110	Renal Pathophysiology	Considers the normal physiology of the kidney and the pathophysiology of renal disease. Renal regulation of sodium, potassium, acid, and water balance are emphasized as are the mechanism and consequences of renal failure. Included also are the pathology and pathophysiology of clinical renal disorders such as acute and chronic glomerulonephritis, pyelonephritis, and vascular disease. New molecular insights into transporter mutations and renal disease are discussed. Only HST students may register under HST.110, graded P/D/F. Enrollment limited.	true	Spring	Graduate	4-0-8 [P/D/F]	7.05 or permission of instructor	null	false	false	false	False	False	False
HST.111	Renal Pathophysiology	Considers the normal physiology of the kidney and the pathophysiology of renal disease. Renal regulation of sodium, potassium, acid, and water balance are emphasized as are the mechanism and consequences of renal failure. Included also are the pathology and pathophysiology of clinical renal disorders such as acute and chronic glomerulonephritis, pyelonephritis, and vascular disease. New molecular insights into transporter mutations and renal disease are discussed. Only HST students may register under HST.110, graded P/D/F. Enrollment limited.	true	Spring	Graduate	4-0-8	7.05 and permission of instructor	null	false	false	false	False	False	False
HST.121	Gastroenterology	Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and associated pancreatic, liver, and biliary systems. Emphasis on the molecular and pathophysiological basis of disease where known. Covers gross and microscopic pathology and clinical aspects. Formal lectures given by core faculty, with some guest lectures by local experts. Selected seminars conducted by students with supervision of faculty. Only HST students may register under HST.120, graded P/D/F. Enrollment limited.	true	Fall, Fall, IAP, Spring, Summer, IAP, Spring	Graduate	3-1-2	Biology (GIR), Physics I (GIR), 7.05, and permission of instructor	null	false	false	false	False	False	False
HST.130	Neuroscience	Comprehensive study of neuroscience where students explore the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Includes some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Limited to 50 HST students.	true	Fall	Graduate	6-3-6 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.131	Neuroscience	Comprehensive study of neuroscience where students explore the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Includes some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Only HST students may register under HST.130, graded P/D/F. Limited to 50.	true	Fall	Graduate	6-3-6	Permission of instructor	null	false	false	false	False	False	False
HST.147	Biochemistry and Metabolism	First-year graduate level intensive subject in human biochemistry and physiological chemistry that focuses on intermediary metabolism, structures of key intermediates and enzymes important in human disease. Subject is divided into four areas: carbohydrates, lipids, amino acids and nucleic acids. The importance of these areas is underscored with examples from diseases and clinical correlations. Preparatory sessions meet in August. Only HST students may register under HST.146, graded P/D/F. Enrollment limited.	true	Fall, IAP, Spring, Summer, IAP, Spring	Graduate	4-0-5	Permission of instructor	null	false	false	false	False	False	False
HST.151	Principles of Pharmacology	Covers both general pharmacological principles (pharmacodynamics, toxicology, pharmacokinetics, pharmacogenetics, drug interactions, pharmacoepidemiology, pharmaco-economics, and the placebo effect), and important clinical pharmacology areas (anti-microbials, general anesthetics, local anesthetics, autonomic modulation, anti-dysrhythmics, hypertension, heart failure, diabetes, anti-inflammatory drugs for rheumatology, immunomodulation for organ transplant, cancer chemotherapy, neuropsychopharmacology, opioids and opioid use disorder, cannabinoids, and drug delivery engineering). In addition, students taking the subject for credit contribute to teaching by presenting and analyzing clinical cases and therapeutic strategies. Highly recommended that students have prior education in human physiology and pathophysiology. Subject follows HMS calendar. Restricted to HST MD & HST PhD students.	true	IAP, Spring, Summer, IAP, Spring	Graduate	6-0-6	Biology (GIR), Physics I (GIR), and 7.05	null	false	false	false	False	False	False
HST.160	Genetics in Modern Medicine	Provides a foundation for understanding the relationship between molecular biology, genetics, and medicine. Starts with an introduction to molecular genetics, and quickly transitions to the genetic basis of diseases, including chromosomal, mitochondrial and epigenetic disease. Translation of clinical understanding into analysis at the level of the gene, chromosome, and molecule; the concepts and techniques of molecular biology and genomics; and the strategies and methods of genetic analysis. Includes diagnostics (prenatal and adult), cancer genetics, and the development of genetic therapies (RNA, viral, and genome editing). The clinical relevance of these areas is underscored with patient presentations. Only HST students may register under HST.160, graded P/D/F.	true	Fall	Graduate	2-0-4 [P/D/F]	7.05	null	false	false	false	False	False	False
HST.161	Genetics in Modern Medicine	Provides a foundation for understanding the relationship between molecular biology, genetics, and medicine. Starts with an introduction to molecular genetics, and quickly transitions to the genetic basis of diseases, including chromosomal, mitochondrial and epigenetic disease. Translation of clinical understanding into analysis at the level of the gene, chromosome, and molecule; the concepts and techniques of molecular biology and genomics; and the strategies and methods of genetic analysis. Includes diagnostics (prenatal and adult), cancer genetics, and the development of genetic therapies (RNA, viral, and genome editing). The clinical relevance of these areas is underscored with patient presentations. Only HST students may register under HST.160, graded P/D/F.	true	Fall	Graduate	2-0-4	7.05	null	false	false	false	False	False	False
HST.162	Molecular Diagnostics and Bioinformatics	Introduction of molecular diagnostic methods in medicine and relevant bioinformatics methods. Discussion of principles of molecular testing for diagnosis of somatic and germline diseases using FISH, classical genotyping, array CGH, next generation sequencing, and other technologies. Case conferences emphasize clinical correlation and integration of information from multiple diagnostic tests. Bioinformatics lectures, problem sets, and laboratory sessions will introduce key concepts in biological sequence analysis and provide experience with bioinformatics tools. HST.015 and HST.191 recommended. Only HST students may register under HST.162, P/D/F. Enrollment limited, preference to HST students.	true	Fall	Graduate	2-0-4 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.163	Molecular Diagnostics and Bioinformatics	Introduction of molecular diagnostic methods in medicine and relevant bioinformatics methods. Discussion of principles of molecular testing for diagnosis of somatic and germline diseases using FISH, classical genotyping, array CGH, next generation sequencing, and other technologies. Case conferences emphasize clinical correlation and integration of information from multiple diagnostic tests. Bioinformatics lectures, problem sets, and laboratory sessions will introduce key concepts in biological sequence analysis and provide experience with bioinformatics tools. HST.015 and HST.191 recommended. Only HST students may register under HST.162, P/D/F. Enrollment limited, preference to HST students.	true	Fall	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
HST.164	Principles of Biomedical Imaging	Reviews fundamental principles and techniques underlying modern biomedical imaging, as well as their application in modern medicine. Particular emphasis on magnetic resonance; also covers ultrasound, computed tomography, positron emission tomography and optical techniques. Didactic lectures accompanied by problem sets and experiments with portable magnetic resonance systems and ultrasound systems. Focuses on the quantitative aspects of biomedical imaging and requires a knowledge of differential equations, MATLAB, and intermediate-level physics. Only HST students may register under HST.164, P/D/F. Restricted to HST students.	true	IAP	Graduate	2-0-4 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.165	Principles of Biomedical Imaging	Reviews fundamental principles and techniques underlying modern biomedical imaging, as well as their application in modern medicine. Particular emphasis on magnetic resonance; also covers ultrasound, computed tomography, positron emission tomography and optical techniques. Didactic lectures accompanied by problem sets and experiments with portable magnetic resonance systems and ultrasound systems. Focuses on the quantitative aspects of biomedical imaging and requires a knowledge of differential equations, MATLAB, and intermediate-level physics. Only HST students may register under HST.164, P/D/F. Restricted to HST students.	true	IAP	Graduate	2-0-4	Permission of instructor	null	false	false	false	False	False	False
HST.175	Cellular and Molecular Immunology	Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Limited to 45.	true	Fall	Graduate	6-0-6 [P/D/F]	7.05	null	false	false	false	False	False	False
HST.176	Cellular and Molecular Immunology	Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Only HST students may register under HST.175, graded P/D/F. Limited to 45.	true	Fall	Graduate	6-0-6	7.05	null	false	false	false	False	False	False
HST.191	Introduction to Biostatistics	Provides training in the use of statistics to comprehend, reason about, and communicate findings from the biomedical sciences, with an emphasis on critical reading of studies published in the literature. Considers assessment of the importance of chance in the interpretation of experimental data from randomized studies and clinical trials. Topics surveyed include basic probability theory; approximate and exact inferential methods such as chi-squared and t-tests, ANOVA, and their permutation-based analogues; linear and generalized linear regression models; survival analysis; causal inference; and statistical data analysis using high-level programming languages such as R. Enrollment restricted to students in the HST program.	true	Summer, IAP, Spring	Graduate	3-0-3	Calculus II (GIR)	null	false	false	false	False	False	False
HST.192	Medical Decision Analysis and Probabilistic Medical Inference	Teaches the essentials of quantitative diagnostic reasoning and medical decision analysis. Guides participants through the process of choosing an appropriate contemporary medical problem in which risk-benefit tradeoffs play a prominent role, conducting a decision analysis, and ultimately publishing the results in a medical journal. Topics include decision trees, influence diagrams, Markov decision models and Monte Carlo simulation, methods for quantifying patient values, Bayesian inference, decision thresholds, and the cognitive science of medical decision making. HST.191 recommended. Limited to 8; preference to HST students.	true	IAP	Graduate	2-0-2 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.195	Clinical Epidemiology	Introduces methods for the generation, analysis, and interpretation of data for clinical research. Major topics include the design of surveys, predictive models, randomized trials, clinical cohorts, and analyses of electronic health records. Prepares students to formulate well-defined research questions, design data collection, evaluate algorithms for clinical prediction, design studies for causal inference, and identify and prevent biases in clinical research. Emphasizes critical thinking and practical applications, including daily assignments based on articles published in major clinical journals and the discussion of a case study each week. Trains students to comprehend, critique, and communicate findings from the biomedical literature. Familiarity with regression modeling and basic statistical theory is a prerequisite. Only HST students may register under HST.194, graded P/D/F. Enrollment limited; restricted to medical and graduate students.	true	IAP, Spring	Graduate	1-0-1	HST.190	null	false	false	false	False	False	False
HST.196	Teaching Health Sciences and Technology	Provides teaching experience (classroom, laboratory, field, recitation, tutorial) under the direction of faculty member(s). Students may prepare instructional materials, lead discussion groups, provide individualized instruction, monitor students' progress, and gain experience delivering other educational elements. Limited to qualified graduate students.	true	Fall, IAP, Spring, Summer	Graduate	rranged [P/D/F]	null	null	false	false	false	False	False	False
HST.198	Independent Study in Health Sciences and Technology	Opportunity for independent study of health sciences and technology under regular supervision by an HST faculty member. Projects require prior approval from the HST Academic Office, as well as a substantive paper.	true	Fall, IAP, Spring, Summer	Graduate	rranged	Permission of instructor	null	false	false	false	False	False	False
HST.200	Introduction to Clinical Medicine	Intensive preparation for clinical clerkships that introduces the basic skills involved in examination of the patient in addition to history taking and the patient interview. Provides exposure to clinical problems in medicine, surgery, and pediatrics. Students report their findings through history taking and oral presentations. Restricted to MD program students.	true	IAP, Spring	Graduate	9-19-12 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.201	Introduction to Clinical Medicine and Medical Engineering I	Develop skills in patient interviewing and physical examination; become proficient at organizing and communicating clinical information in both written and oral forms; begin integrating history, physical, and laboratory data with pathophysiologic principles; and become familiar with the clinical decision-making process and broad economic, ethical, and sociological issues involved in patient care. There are two sections: one at Mount Auburn Hospital and one at West Roxbury VA Hospital, subsequent registration into HST.202 must be continued at the same hospital as HST.201. Restricted to MEMP students.	true	Summer	Graduate	0-20-0 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.202	Introduction to Clinical Medicine and Medical Engineering II	Strengthens the skills developed in HST.201 through a six-week clerkship in medicine at a Harvard-affiliated teaching hospital. Students serve as full-time members of a ward team and participate in longitudinal patient care. In addition, students participate in regularly scheduled teaching conferences focused on principles of patient management. Restricted to MEMP students.	true	Fall, IAP, Spring, Summer	Graduate	0-20-0 [P/D/F]	HST.201	null	false	false	false	False	False	False
HST.207	Introduction to Clinical Medicine and Medical Engineering	Introduction to the intricacies of clinical decision-making through broad exposure to how clinicians think and work in teams. Instruction provided in patient interviewing and physical examination; organizing and communicating clinical information in written and oral forms; and integrating history, physical, and laboratory data with pathophysiologic principles. Attention to the economic, ethical, and sociological issues involved in patient care. Consists of immersive clinical experiences at Massachusetts General Hospital, leveraging extensive educational resources across inpatient clinical floors, ambulatory clinics, procedural/surgical suites, diagnostic testing areas, simulation learning lab, and didactic settings, followed by a focused experience in which students develop a proposal to solve an unmet need identified during their clinical experiences. Equivalent to combination of HST.201 and HST.202. Restricted to HST MEMP students.	true	Spring	Graduate	0-30-0 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.220	Introduction to the Care of Patients	Provides an introduction to the care of patients through opportunities to observe and participate in doctor-patient interaction in clinical settings and a longitudinal preceptorship experience with HST alumni physicians. Students are exposed to some of the practical realities of providing patient care. Topics include basic interviewing; issues of ethics, bias, and confidentiality; and other aspects of the doctor-patient relationship. The introductory session is held at HMS or Massachusetts General Hospital and the preceptorships are at several Harvard hospitals in Boston. Requirements include attendance at the introductory session and meetings scheduled with the preceptor.	true	Spring	Graduate	1-0-2 [P/D/F]	Permission of instructor	null	false	false	false	False	False	False
HST.240	Translational Medicine Preceptorship	Individually designed preceptorship joins together scientific research and clinical medicine. Students devote approximately half of their time to clinical experiences, and the remaining part to scholarly work in basic or clinical science. The two might run concomitantly or in series. Follow a clinical preceptor's daily activity, including aspects of patient care, attending rounds, conferences, and seminars. Research involves formal investigation of a focused and directed issue related to selected clinical area. Final paper required. Limited to students in the GEMS Program.	true	Fall, Spring, Summer	Graduate	0-12-0	HST.035	null	false	false	false	False	False	False
HST.420[J]	Principles and Practice of Assistive Technology	Students work closely with people with disabilities to develop assistive and adaptive technologies that help them live more independently. Covers design methods and problem-solving strategies; human factors; human-machine interfaces; community perspectives; social and ethical aspects; and assistive technology for motor, cognitive, perceptual, and age-related impairments. Prior knowledge of one or more of the following areas useful: software; electronics; human-computer interaction; cognitive science; mechanical engineering; control; or MIT hobby shop, MIT PSC, or other relevant independent project experience. Enrollment may be limited.	true	Fall	Undergraduate	2-4-6	Permission of instructor	2.78[J], 6.4530[J]	false	false	false	False	False	False
HST.431[J]	Infections and Inequalities: Interdisciplinary Perspectives on Global Health	Examines case studies in infectious disease outbreaks to demonstrate how human health is a product of multiple determinants, such as biology, sociocultural and historical factors, politics, economic processes, and the environment. Analyzes how structural inequalities render certain populations vulnerable to illness and explores the moral and ethical dimensions of public health and clinical interventions to promote health. Limited to 25.	true	Spring	Undergraduate	3-0-9	null	11.134[J]	false	false	false	False	Social Sciences	False
HST.434	Evolution of an Epidemic (Study Abroad)	Examines the medical, scientific, public health and policy responses to a new disease, by focusing on the evolution of the AIDS epidemic. Begins with a review of how this new disease was first detected in the US and Africa, followed by the scientific basis as to how HIV causes profound dysfunction of the body's immune defense mechanisms, the rational development of drugs, the challenge of an HIV vaccine, and how public health and policy decisions have influenced the course of the global epidemic. Class conducted in Johannesburg Durban, South Africa. Open to all majors. Limited to 20. Application required; see class website for eligibility details.	true	IAP	Undergraduate	3-0-1 [P/D/F]	null	null	false	false	false	False	False	False
HST.438[J]	Viruses, Pandemics, and Immunity	Covers the history of infectious diseases, basics of virology, immunology, and epidemiology, and ways in which diagnostic tests, vaccines, and antiviral therapies are currently designed and manufactured. Examines the origins of inequities in infection rates in society, and issues pertinent to vaccine safety. Final project explores how to create a more pandemic-resilient world. Subject can count toward the 6-unit discovery-focused credit limit for first-year students. Preference to first-year students; all others should take HST.439.	true	Spring	Undergraduate	2-0-1	null	5.002[J], 10.380[J]	false	false	false	False	False	False
HST.439[J]	Viruses, Pandemics, and Immunity	Covers the history of infectious diseases, basics of virology, immunology, and epidemiology, and ways in which diagnostic tests, vaccines, and antiviral therapies are currently designed and manufactured. Examines the origins of inequities in infection rates in society, and issues pertinent to vaccine safety. Final project explores how to create a more pandemic-resilient world. HST.438 intended for first-year students; all others should take HST.439.	true	Spring	Undergraduate	2-0-1	null	5.003[J], 8.245[J], 10.382[J]	false	false	false	False	False	False
HST.450[J]	Biological Physics	Designed to provide seniors and first-year graduate students with a quantitative, analytical understanding of selected biological phenomena. Topics include experimental and theoretical basis for the phase boundaries and equation of state of concentrated protein solutions, with application to diseases such as sickle cell anemia and cataract. Protein-ligand binding and linkage and the theory of allosteric regulation of protein function, with application to proteins as stores as transporters in respiration, enzymes in metabolic pathways, membrane receptors, regulators of gene expression, and self-assembling scaffolds. The physics of locomotion and chemoreception in bacteria and the biophysics of vision, including the theory of transparency of the eye, molecular basis of photo reception, and the detection of light as a signal-to-noise discrimination.	true	Spring	Graduate	4-0-8	8.044 recommended but not necessary	8.593[J]	false	false	false	False	False	False
HST.452[J]	Statistical Physics in Biology	A survey of problems at the interface of statistical physics and modern biology: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, phylogenetic trees. Physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, elements of protein folding. Considerations of force, motion, and packaging; protein motors, membranes. Collective behavior of biological elements; cellular networks, neural networks, and evolution.	false	Fall	Graduate	3-0-9	8.333 or permission of instructor	8.592[J]	false	false	false	False	False	False
HST.460[J]	Statistics for Neuroscience Research	A survey of statistical methods for neuroscience research. Core topics include introductions to the theory of point processes, the generalized linear model, Monte Carlo methods, Bayesian methods, multivariate methods, time-series analysis, spectral analysis and state-space modeling. Emphasis on developing a firm conceptual understanding of the statistical paradigm and statistical methods primarily through analyses of actual experimental data.	true	Spring	Graduate	3-0-9	Permission of instructor	9.073[J]	false	false	false	False	False	False
HST.482[J]	Biomedical Signal and Image Processing	Fundamentals of digital signal processing with emphasis on problems in biomedical research and clinical medicine. Basic principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. Lab projects, performed in MATLAB, provide practical experience in processing physiological data, with examples from cardiology, speech processing, and medical imaging. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the biological signals processed in the labs. Students taking graduate version complete additional assignments.	true	Spring	Undergraduate	3-1-8	(6.3700 or permission of instructor) and (2.004, 6.3000, 16.002, or 18.085)	6.8801[J]	false	false	false	False	False	False
HST.500	Frontiers in (Bio)Medical Engineering and Physics	Provides a framework for mapping research topics at the intersection of medicine and engineering/physics in the Harvard-MIT community and covers the different research areas in MEMP (for example, regenerative biomedical technologies, biomedical imaging and biooptics). Lectures provide fundamental concepts and consider what's hot, and why, in each area. Training in scientific proposal writing (thesis proposals, fellowship applications, or research grant applications) through writing workshops. Topics include how to structure a novel research project, how to position research within the scientific community, how to present preliminary data effectively, and how to give and respond to peer reviews.	true	Spring	Graduate	3-0-9	null	null	false	false	false	False	False	False
HST.504[J]	Topics in Computational Molecular Biology	Covers current research topics in computational molecular biology. Recent research papers presented from leading conferences such as the International Conference on Computational Molecular Biology (RECOMB) and the Conference on Intelligent Systems for Molecular Biology (ISMB). Topics include original research (both theoretical and experimental) in comparative genomics, sequence and structure analysis, molecular evolution, proteomics, gene expression, transcriptional regulation, biological networks, drug discovery, and privacy. Recent research by course participants also covered. Participants will be expected to present individual projects to the class.	true	Fall	Graduate	3-0-9	6.8701, 18.417, or permission of instructor	18.418[J]	false	false	false	False	False	False
HST.506[J]	Computational Systems Biology: Deep Learning in the Life Sciences	Presents innovative approaches to computational problems in the life sciences, focusing on deep learning-based approaches with comparisons to conventional methods. Topics include protein-DNA interaction, chromatin accessibility, regulatory variant interpretation, medical image understanding, medical record understanding, therapeutic design, and experiment design (the choice and interpretation of interventions). Focuses on machine learning model selection, robustness, and interpretation. Teams complete a multidisciplinary final research project using TensorFlow or other framework. Provides a comprehensive introduction to each life sciences problem, but relies upon students understanding probabilistic problem formulations. Students taking graduate version complete additional assignments.	false	Spring	Graduate	3-0-9	Biology (GIR) and (6.3700 or 18.600)	6.8710[J]	false	false	false	False	False	False
HST.507[J]	Advanced Computational Biology: Genomes, Networks, Evolution	See description for 6.8701. Additionally examines recent publications in the areas covered, with research-style assignments. A more substantial final project is expected, which can lead to a thesis and publication.	true	Fall	Graduate	4-0-8	(Biology (GIR), 6.1210, and 6.3700) or permission of instructor	6.8700[J]	false	false	false	False	False	False
HST.508[J]	Evolutionary and Quantitative Genomics	Develops deep quantitative understanding of basic forces of evolution, molecular evolution, genetic variations and their dynamics in populations, genetics of complex phenotypes, and genome-wide association studies. Applies these foundational concepts to cutting-edge studies in epigenetics, gene regulation and chromatin; cancer genomics and microbiomes. Modules consist of lectures, journal club discussions of high-impact publications, and guest lectures that provide clinical correlates. Homework assignments and final projects develop practical experience and understanding of genomic data from evolutionary principles.	true	Fall	Graduate	4-0-8	Permission of instructor	1.872[J]	false	false	false	False	False	False
HST.515[J]	Aerospace Biomedical and Life Support Engineering	Fundamentals of human performance, physiology, and life support impacting engineering design and aerospace systems. Topics include effects of gravity on the muscle, skeletal, cardiovascular, and neurovestibular systems; human/pilot modeling and human/machine design; flight experiment design; and life support engineering for extravehicular activity (EVA). Case studies of current research are presented. Assignments include a design project, quantitative homework sets, and quizzes emphasizing engineering and systems aspects.	true	Spring	Graduate	3-0-9	16.06, 16.400, or permission of instructor	16.423[J], IDS.337[J]	false	false	false	False	False	False
HST.518[J]	Human Systems Engineering	Provides a fundamental understanding of human factors that must be taken into account in the design and engineering of complex aviation, space, and medical systems. Focuses primarily on derivation of human engineering design criteria from sensory, motor, and cognitive sources. Includes principles of displays, controls and ergonomics, manual control, the nature of human error, basic experimental design, and human-computer interaction in supervisory control settings. Students taking graduate version complete a research project with a final written report and oral presentation.	true	Fall	Graduate	3-0-9	6.3700, 16.09, or permission of instructor	16.453[J]	false	false	false	False	False	False
HST.522[J]	Biomaterials: Tissue Interactions	Principles of materials science and cell biology underlying the development and implementation of biomaterials for the fabrication of medical devices/implants, including artificial organs and matrices for tissue engineering and regenerative medicine. Employs a conceptual model, the "unit cell process for analysis of the mechanisms underlying wound healing and tissue remodeling following implantation of biomaterials/devices in various organs, including matrix synthesis, degradation, and contraction. Methodology of tissue and organ regeneration. Discusses methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.	true	Fall	Graduate	3-0-9	(Biology (GIR), Chemistry (GIR), and Physics I (GIR)) or permission of instructor	2.79[J]	false	false	false	False	False	False
HST.523[J]	Cell-Matrix Mechanics	Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.	true	Fall	Graduate	3-0-9	(Biology (GIR), Chemistry (GIR), and 2.001) or permission of instructor	2.785[J]	false	false	false	False	False	False
HST.524[J]	Design of Medical Devices and Implants	Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants.	true	Spring	Graduate	3-0-9	(Biology (GIR), Chemistry (GIR), and Physics I (GIR)) or permission of instructor	2.782[J]	false	false	false	False	False	False
HST.525[J]	Tumor Microenvironment and Immuno-Oncology: A Systems Biology Approach	Provides theoretical background to analyze and synthesize the most up-to-date findings from both laboratory and clinical investigations into solid tumor pathophysiology. Covers different topics centered on the critical role that the tumor microenvironment plays in the growth, invasion, metastasis and treatment of solid tumors. Develops a systems-level, quantitative understanding of angiogenesis, extracellular matrix, metastatic process, delivery of drugs and immune cells, and response to conventional and novel therapies, including immunotherapies. Discussions provide critical comments on the challenges and the future opportunities in research on cancer and in establishment of novel therapeutic approaches and biomarkers to guide treatment.	false	Fall	Graduate	2-0-4	null	10.548[J]	false	false	false	False	False	False

ES.112

Philosophy of Love

Explores the nature of love through works of philosophy, literature, film, poetry, and individual experience. Investigates the distinction among eros (desiring or appreciative love), philia (mutuality), and agape (love as pure giving). Students discuss ideas of love as a feeling, an action, a species of 'knowing someone,' or a way to give or take. Authors include Plato, Kant, Buber, D. H. Lawrence, Rumi, and Aristotle. Preference to students in ESG and Concourse.

true

Spring

Undergraduate

4-0-8

null

false

False

Humanities

CI-H

ES.113

Ancient Greek Philosophy and Mathematics

Explores the relationship between ancient Greek philosophy and mathematics. Investigates how ideas of definition, reason, argument and proof, rationality/irrationality, number, quality and quantity, truth, and even the idea of an idea were shaped by the interplay of philosophic and mathematical inquiry. Examines how discovery of the incommensurability of magnitudes challenged the Greek presumption that the cosmos is fully understandable. Explores the influence of mathematics on ancient Greek ethical theories. Authors: Euclid, Plato, Aristotle, Nicomachus, Theon of Smyrna, Bacon, Descartes, Dedekind, and Newton. Preference to students in Concourse and ESG.

true

Spring

Undergraduate

3-0-9

null

false

False

Humanities

CI-H

ES.114

Non-violence as a Way of Life

Addresses the philosophical question of what a non-violent life entails. Investigates its ethical dimensions and challenges, and considers whether we can derive a comprehensive moral theory from the principle of non-violence. Discusses the issues of lying, the duty to forgive, non-violent communication, the ethics of our relationship to anger, the possibility of loving enemies, and the ethics of punishment and rehabilitation. Includes readings from primary exponents of non-violence, such as Tolstoy, Gandhi and King.

true

Fall

Undergraduate

3-0-9

null

false

False

Humanities

CI-H

ES.9112

Philosophy of Love - MIT Prison Initiative

Explores the nature of love through works of philosophy, literature, film, poetry, and individual experience. Investigates the distinction among eros (desiring or appreciative love), philia (mutuality), and agape (love as pure giving). Students discuss ideas of love as a feeling, an action, a species of 'knowing someone,' or a way to give or take. Authors include Plato, Kant, Buber, D. H. Lawrence, Rumi, and Aristotle. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 10.

true

Spring

Undergraduate

3-0-9

null

false

False

Humanities

CI-H

ES.9114

Non-violence as a Way of Life - MIT Prison Initiative

Addresses the philosophical question of what a non-violent life entails. Investigates its ethical dimensions and challenges, and considers whether we can derive a comprehensive moral theory from the principle of non-violence. Discusses the issues of lying, the duty to forgive, non-violent communication, the ethics of our relationship to anger, the possibility of loving enemies, and the ethics of punishment and rehabilitation. Includes readings from primary exponents of non-violence, such as Tolstoy, Gandhi and King. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 10.

true

Fall

Undergraduate

3-0-9

null

false

False

Humanities

CI-H

ES.92

Authenticity - MIT Prison Initiative

Explores the question of how to live an authentic life, through works of western and eastern philosophy and contemporary psychology. Topics include emotions, anger, honesty, forgiveness, non-violent communication, conflict resolution, kindness and cruelty and compassion. Taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Limited to 12.

true

Fall, Spring

Undergraduate

3-0-3 [P/D/F]

null

false

False

ES.010

Chemistry of Sports: Understanding How Exercise Affects Your Body

Students apply chemistry knowledge to physical fitness through the study of three sports: swimming, cycling, and running. Classroom component focuses on nutrition, exercise, anatomy, physiology, and the chemistry of supplements and sports equipment. Laboratory component focuses on training for and completion of triathlon competition. Students may earn up to 2 PE points during the term by attending supervised triathlon training workouts. Preference to students in ESG.

true

Spring

Undergraduate

2-1-3 [P/D/F]

null

false

False

ES.011

Kitchen Chemistry

An experimental and "hands-on" approach to applied chemistry in cooking. Students perform experiments to illustrate chemical principles, such as extraction, denaturation, and phase changes. Preference to students in ESG.

true

Spring

Undergraduate

2-1-3 [P/D/F]

null

false

False

ES.100

An Introduction to Maker Skills

Introduction to making and use of MIT's maker spaces intended to build skills needed for designing, conducting, and completing experiments and design projects, such as may be encountered in undergraduate classwork and research activities. Includes maker space training (i.e., wood shop, digital fabrication, and electronics fabrication) and open-ended design projects, with work evenly divided between class, homework, and maker space activities. Limited to 12 by makerspace training and scheduling; priority given to ESG students.

true

Spring

Undergraduate

1-1-1 [P/D/F]

null

false

False

ES.200

ESG Undergraduate Teaching

An opportunity to assist in the teaching of subjects in ESG in biology, chemistry, humanities and social sciences, mathematics, and physics. Student instructors may be involved in grading, running problemsolving sessions, or teaching classes depending on experience and interest. Qualified students may also develop and teach undergraduate seminars under the supervision of an appropriate faculty or staff member. Student instructors meet weekly with staff to discuss their teaching and cover a variety of topics related to effective teaching techniques. Limited to students in ESG.

true

Fall

Undergraduate

2-0-4 [P/D/F]

Permission of instructor

null

false

False

ES.201

ESG Undergraduate Teaching

An opportunity to assist in the teaching of subjects in ESG in biology, chemistry, humanities and social sciences, mathematics, and physics. Student instructors may be involved in grading, running problem solving sessions, or teaching classes depending on experience and interest. Qualified students may also develop and teach undergraduate seminars under the supervision of an appropriate faculty or staff member. Student instructors meet every other week with staff to discuss their teaching and cover a variety of topics related to effective teaching techniques. Limited to students in ESG.

true

Spring

Undergraduate

1-0-2 [P/D/F]

Permission of instructor

null

false

False

ES.210

ESG Independent Study

Opportunity for independent study under regular supervision by a staff member. Projects require prior approval, as well as a written proposal and a final report. Limited to students in ESG.

true

Fall, IAP, Spring, Summer

Undergraduate

rranged [P/D/F]

Permission of instructor

null

false

False

ES.UR

Undergraduate Research in ESG

For students wishing to pursue undergraduate research opportunities in the Experimental Study Group. Limited to students in ESG.

true

Fall, IAP, Spring, Summer

Undergraduate

rranged [P/D/F]

null

false

False

ES.S10

Special Seminar in Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S11

Special Seminar in Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring, Fall, IAP, Spring, Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S20

Special Seminar in Mathematics

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

IAP

Undergraduate

rranged [P/D/F]

null

false

False

ES.S21

Special Seminar in Mathematics

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, IAP, Spring, Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S30

Special Seminar in Engineering and Computer Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S31

Special Seminar in Engineering and Computer Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, IAP, Fall, Spring, Fall, IAP, Spring, Spring, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S40

Special Seminar in the Humanities

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S41

Special Seminar in the Humanities

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, Spring, Fall, IAP, Spring, Spring, Spring

Undergraduate

rranged

null

false

False

ES.S42

Special Seminar in the Humanities

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, Spring

Undergraduate

rranged

null

false

False

ES.S50

Special Seminar in the Arts

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall

Undergraduate

rranged [P/D/F]

null

false

False

ES.S51

Special Seminar in the Arts

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, IAP, Spring, Spring, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S60

Special Seminar in Social Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S601

Special Topics in Computer Science

Covers topics not included in the permanent curriculum. Limited to 10. Preference given to ESG students.

true

Fall

Undergraduate

rranged

null

false

False

ES.S602

Special Topics in Computer Science

Covers topics not included in the permanent curriculum. Preference given to ESG students.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S61

Special Seminar in Social Science

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S70

Special Seminar in Interdisciplinary Studies

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Fall, Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S71

Special Seminar in Interdisciplinary Studies

Covers topics not included in the permanent curriculum. May not be used for GIR credit, but may be repeated for credit with permission of instructor. Preference to students in ESG.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S90

Special Studies in the MIT Initiative for Teaching Incarcerated Individuals

Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S91

Special Studies in the MIT Initiative for Teaching Incarcerated Individuals

Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S92

Special Studies in the MIT Initiative for Teaching Incarcerated Individuals

Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.

true

Spring

Undergraduate

rranged [P/D/F]

null

false

False

ES.S93

Special Studies in the MIT Initiative for Teaching Incarcerated Individuals (New)

Seminar taught inside a secure Massachusetts correctional facility with a mix of MIT students and incarcerated students. Topics vary from year to year. Limited to 10.

true

Fall, Spring

Undergraduate

rranged [P/D/F]

null

false

False

HST.010

Human Functional Anatomy

Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body and present evolving knowledge of genes responsible for normal and abnormal anatomy. Lecturers focus on current problems in organ system research. Only HST students may register under HST.010, graded P/D/F. Lab fee.

true

Fall

Graduate

3-11-10 [P/D/F]

Permission of instructor

null

false

False

HST.011

Human Functional Anatomy

Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body and present evolving knowledge of genes responsible for normal and abnormal anatomy. Lecturers focus on current problems in organ system research. Only HST students may register under HST.010, graded P/D/F. Lab fee. Enrollment restricted to graduate students.

true

Fall

Graduate

3-11-10

Permission of instructor

null

false

False

HST.015

MATLAB for Medicine

Practical introduction to use of quantitative methods in medicine and health research. Each session covers a different topic in quantitative techniques, provides an application to medicine, and includes a modeling activity using MATLAB. Students also complete problem sets. Restricted to first year HST MD students.

true

Summer

Graduate

2-0-4 [P/D/F]

null

false

False

HST.016

Artificial Intelligence in Health Care I (New)

Introduces fundamental concepts at the core of artificial intelligence (AI), as applied to health care problems. Didactic lectures, problem sets, and review/analyses of seminal papers in the field. Specific topics include: deep learning for clinical risk stratification, explaining complex machine learning models, bias and fairness in clinical machine learning, large language models, and Generative Pretrained Transformers (GPT models). No background in AI or machine learning is required. Only HST students may register under HST.016, which is graded P/D/F. Enrollment limited.

true

Summer

Graduate

2-0-4 [P/D/F]

Permission of instructor

null

false

False

HST.017

Artificial Intelligence in Health Care I (New)

Introduces fundamental concepts at the core of artificial intelligence (AI), as applied to health care problems. Didactic lectures, problem sets, and review/analyses of seminal papers in the field. Specific topics include: deep learning for clinical risk stratification, explaining complex machine learning models, bias and fairness in clinical machine learning, large language models, and Generative Pretrained Transformers (GPT models). No background in AI or machine learning is required. Only HST students may register under HST.016, which is graded P/D/F. Enrollment limited.

true

Summer

Graduate

2-0-4

Permission of instructor

null

false

False

HST.018

Artificial Intelligence in Health Care II (New)

Builds upon on the core concepts covered in HST.017. Student selected projects explore specific clinical problems. Student groups are paired with machine learning experts who provide guidance. Only HST students may register under HST.018, which is graded P/D/F.

true

IAP

Graduate

2-0-4 [P/D/F]

(HST.016 or HST.017) and permission of instructor

null

false

False

HST.019

Artificial Intelligence in Health Care II (New)

Builds upon on the core concepts covered in HST.017. Student selected projects explore specific clinical problems. Student groups are paired with machine learning experts who provide guidance. Only HST students may register under HST.018, which is graded P/D/F.

true

IAP

Graduate

2-0-4

(HST.016 or HST.017) and permission of instructor

null

false

False

HST.020

Musculoskeletal Pathophysiology

Growth and development of normal bone and joints, the biophysics and biomechanics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements. Only HST students may register under HST.020, graded P/D/F. Enrollment limited; restricted to medical and graduate students.

true

Spring

Graduate

3-0-3 [P/D/F]

HST.030 and HST.160

null

false

False

HST.021

Musculoskeletal Pathophysiology

Growth and development of normal bone and joints, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements. Only HST students may register under HST.020, graded P/D/F. Enrollment limited; restricted to medical and graduate students.

true

Spring

Graduate

3-0-3

HST.030 and HST.160

null

false

False

HST.030

Human Pathology

Introduction to the functional structure of normal cells and tissues; pathologic principles of cellular adaptation and injury, inflammation, circulatory disorders, immunologic injury, infection, genetic disorders, and neoplasia in humans. Lectures, conferences emphasizing clinical correlations and contemporary experimental biology, laboratories with examination of microscopic and gross specimens, and autopsy case studies emphasizing modern pathology practice. Only HST students may register under HST.030, graded P/D/F. Lab fee. Limited to 60; priority to HST students.

true

Fall

Graduate

4-3-8 [P/D/F]

Permission of instructor

null

false

False

HST.031

Human Pathology

Introduction to the functional structure of normal cells and tissues, pathologic principles of cellular adaptation and injury, inflammation, circulatory disorders, immunologic injury, infection, genetic disorders, and neoplasia in humans. Lectures, conferences emphasizing clinical correlations and contemporary experimental biology. Laboratories with examination of microscopic and gross specimens, and autopsy case studies emphasizing modern pathology practice. Only HST students may register under HST.030, graded P/D/F. Lab fee. Enrollment limited.

true

Fall

Graduate

4-3-8

Biology (GIR), Physics I (GIR), and permission of instructor

null

false

False

HST.041

Mechanisms of Microbial Pathogenesis

Deals with the mechanisms of pathogenesis of bacteria, viruses, and other microorganisms. Approach spans mechanisms from molecular to clinical aspects of disease. Topics selected for intrinsic interest and cover the demonstrated spectrum of pathophysiologic mechanisms. Only HST students may register under HST.040, graded P/D/F. Lab fee. Enrollment limited.

true

Fall

Graduate

4-2-6

Biology (GIR), 7.05, and permission of instructor

null

false

False

HST.060

Endocrinology

Physiology and pathophysiology of the human endocrine system. Three hours of lecture and section each week concern individual parts of the endocrine system. Topics also include assay techniques, physiological integration, etc. At frequent clinic sessions, patients are presented who demonstrate clinical problems considered in the didactic lectures. Enrollment limited.

true

Spring

Graduate

3-0-6 [P/D/F]

Biology (GIR), 7.05, and permission of instructor

null

false

False

HST.061

Endocrinology

Physiology and pathophysiology of the human endocrine system. Three hours of lecture and section each week concern individual parts of the endocrine system. Topics include assay techniques, physiological integration, etc. At frequent clinic sessions, patients are presented who demonstrate clinical problems considered in the didactic lectures. Only HST students may register under HST.060, graded P/D/F. Enrollment limited.

true

Spring

Graduate

3-0-6

Biology (GIR), 7.05, and permission of instructor

null

false

False

HST.071

Human Reproductive Biology

Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. Only HST students may register under HST.070, graded P/D/F.

true

Fall, Spring, Fall, Fall, IAP, Spring, Summer, IAP, Spring

Graduate

4-0-2

7.05 and permission of instructor

null

false

False

HST.081

Hematology

Intensive survey of the biology, physiology and pathophysiology of blood with systematic consideration of hematopoiesis, white blood cells, red blood cells, platelets, coagulation, plasma proteins, and hematologic malignancies. Emphasis given equally to didactic discussion and analysis of clinical problems. Enrollment limited.

true

Spring, Fall, Fall, IAP, Spring, Summer, IAP, Spring

Graduate

2-1-3

7.05 and permission of instructor

null

false

False

HST.090

Cardiovascular Pathophysiology

Normal and pathologic physiology of the heart and vascular system. Emphasis includes hemodynamics, electrophysiology, gross pathology, and clinical correlates of cardiovascular function in normal and in a variety of disease states. Special attention given to congenital, rheumatic, valvular heart disease and cardiomyopathy. Only HST students may register under HST.090, graded P/D/F.

true

Spring

Graduate

3-2-10 [P/D/F]

HST.030 or HST.031

null

false

False

HST.091

Cardiovascular Pathophysiology

Normal and pathologic physiology of the heart and vascular system. Emphasis includes hemodynamics, electrophysiology, gross pathology, and clinical correlates of cardiovascular function in normal and in a variety of disease states. Special attention given to congenital, rheumatic, valvular heart disease and cardiomyopathy. Only HST students may register under HST.090, graded P/D/F. Enrollment limited.

true

Spring

Graduate

3-2-10

(HST.030 or HST.031) and permission of instructor

null

false

False

HST.100

Respiratory Pathophysiology

Lectures, seminars, and laboratories cover the histology, cell biology, and physiological function of the lung with multiple examples related to common diseases of the lung. A quantitative approach to the physics of gases, respiratory mechanics, and gas exchange is provided to explain pathological mechanisms. Use of medical ventilators is discussed in lecture and in laboratory experiences. For MD candidates and other students with background in science. Only HST students may register under HST.100, graded P/D/F.

true

Spring

Graduate

4-0-8 [P/D/F]

Physics I (GIR) and 7.05

null

false

False

HST.101

Respiratory Pathophysiology

Lectures, seminars, and laboratories cover the histology, cell biology, and physiological function of the lung with multiple examples related to common diseases of the lung. A quantitative approach to the physics of gases, respiratory mechanics, and gas exchange is provided to explain pathological mechanisms. Use of medical ventilators is discussed in lecture and in laboratory experiences. For MD candidates and other students with background in science. Only HST students may register under HST.100, graded P/D/F. Enrollment limited.

true

Spring

Graduate

4-0-8

Physics I (GIR), 7.05, and permission of instructor

null

false

False

HST.110

Renal Pathophysiology

Considers the normal physiology of the kidney and the pathophysiology of renal disease. Renal regulation of sodium, potassium, acid, and water balance are emphasized as are the mechanism and consequences of renal failure. Included also are the pathology and pathophysiology of clinical renal disorders such as acute and chronic glomerulonephritis, pyelonephritis, and vascular disease. New molecular insights into transporter mutations and renal disease are discussed. Only HST students may register under HST.110, graded P/D/F. Enrollment limited.

true

Spring

Graduate

4-0-8 [P/D/F]

7.05 or permission of instructor

null

false

False

HST.111

Renal Pathophysiology

Considers the normal physiology of the kidney and the pathophysiology of renal disease. Renal regulation of sodium, potassium, acid, and water balance are emphasized as are the mechanism and consequences of renal failure. Included also are the pathology and pathophysiology of clinical renal disorders such as acute and chronic glomerulonephritis, pyelonephritis, and vascular disease. New molecular insights into transporter mutations and renal disease are discussed. Only HST students may register under HST.110, graded P/D/F. Enrollment limited.

true

Spring

Graduate

4-0-8

7.05 and permission of instructor

null

false

False

HST.121

Gastroenterology

Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and associated pancreatic, liver, and biliary systems. Emphasis on the molecular and pathophysiological basis of disease where known. Covers gross and microscopic pathology and clinical aspects. Formal lectures given by core faculty, with some guest lectures by local experts. Selected seminars conducted by students with supervision of faculty. Only HST students may register under HST.120, graded P/D/F. Enrollment limited.

true

Fall, Fall, IAP, Spring, Summer, IAP, Spring

Graduate

3-1-2

Biology (GIR), Physics I (GIR), 7.05, and permission of instructor

null

false

False

HST.130

Neuroscience

Comprehensive study of neuroscience where students explore the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Includes some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Limited to 50 HST students.

true

Fall

Graduate

6-3-6 [P/D/F]

Permission of instructor

null

false

False

HST.131

Neuroscience

Comprehensive study of neuroscience where students explore the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Includes some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Only HST students may register under HST.130, graded P/D/F. Limited to 50.

true

Fall

Graduate

6-3-6

Permission of instructor

null

false

False

HST.147

Biochemistry and Metabolism

First-year graduate level intensive subject in human biochemistry and physiological chemistry that focuses on intermediary metabolism, structures of key intermediates and enzymes important in human disease. Subject is divided into four areas: carbohydrates, lipids, amino acids and nucleic acids. The importance of these areas is underscored with examples from diseases and clinical correlations. Preparatory sessions meet in August. Only HST students may register under HST.146, graded P/D/F. Enrollment limited.

true

Fall, IAP, Spring, Summer, IAP, Spring

Graduate

4-0-5

Permission of instructor

null

false

False

HST.151

Principles of Pharmacology

Covers both general pharmacological principles (pharmacodynamics, toxicology, pharmacokinetics, pharmacogenetics, drug interactions, pharmacoepidemiology, pharmaco-economics, and the placebo effect), and important clinical pharmacology areas (anti-microbials, general anesthetics, local anesthetics, autonomic modulation, anti-dysrhythmics, hypertension, heart failure, diabetes, anti-inflammatory drugs for rheumatology, immunomodulation for organ transplant, cancer chemotherapy, neuropsychopharmacology, opioids and opioid use disorder, cannabinoids, and drug delivery engineering). In addition, students taking the subject for credit contribute to teaching by presenting and analyzing clinical cases and therapeutic strategies. Highly recommended that students have prior education in human physiology and pathophysiology. Subject follows HMS calendar. Restricted to HST MD & HST PhD students.

true

IAP, Spring, Summer, IAP, Spring

Graduate

6-0-6

Biology (GIR), Physics I (GIR), and 7.05

null

false

False

HST.160

Genetics in Modern Medicine

Provides a foundation for understanding the relationship between molecular biology, genetics, and medicine. Starts with an introduction to molecular genetics, and quickly transitions to the genetic basis of diseases, including chromosomal, mitochondrial and epigenetic disease. Translation of clinical understanding into analysis at the level of the gene, chromosome, and molecule; the concepts and techniques of molecular biology and genomics; and the strategies and methods of genetic analysis. Includes diagnostics (prenatal and adult), cancer genetics, and the development of genetic therapies (RNA, viral, and genome editing). The clinical relevance of these areas is underscored with patient presentations. Only HST students may register under HST.160, graded P/D/F.

true

Fall

Graduate

2-0-4 [P/D/F]

7.05

null

false

False

HST.161

Genetics in Modern Medicine

Provides a foundation for understanding the relationship between molecular biology, genetics, and medicine. Starts with an introduction to molecular genetics, and quickly transitions to the genetic basis of diseases, including chromosomal, mitochondrial and epigenetic disease. Translation of clinical understanding into analysis at the level of the gene, chromosome, and molecule; the concepts and techniques of molecular biology and genomics; and the strategies and methods of genetic analysis. Includes diagnostics (prenatal and adult), cancer genetics, and the development of genetic therapies (RNA, viral, and genome editing). The clinical relevance of these areas is underscored with patient presentations. Only HST students may register under HST.160, graded P/D/F.

true

Fall

Graduate

2-0-4

7.05

null

false

False

HST.162

Molecular Diagnostics and Bioinformatics

Introduction of molecular diagnostic methods in medicine and relevant bioinformatics methods. Discussion of principles of molecular testing for diagnosis of somatic and germline diseases using FISH, classical genotyping, array CGH, next generation sequencing, and other technologies. Case conferences emphasize clinical correlation and integration of information from multiple diagnostic tests. Bioinformatics lectures, problem sets, and laboratory sessions will introduce key concepts in biological sequence analysis and provide experience with bioinformatics tools. HST.015 and HST.191 recommended. Only HST students may register under HST.162, P/D/F. Enrollment limited, preference to HST students.

true

Fall

Graduate

2-0-4 [P/D/F]

Permission of instructor

null

false

False

HST.163

Molecular Diagnostics and Bioinformatics

Introduction of molecular diagnostic methods in medicine and relevant bioinformatics methods. Discussion of principles of molecular testing for diagnosis of somatic and germline diseases using FISH, classical genotyping, array CGH, next generation sequencing, and other technologies. Case conferences emphasize clinical correlation and integration of information from multiple diagnostic tests. Bioinformatics lectures, problem sets, and laboratory sessions will introduce key concepts in biological sequence analysis and provide experience with bioinformatics tools. HST.015 and HST.191 recommended. Only HST students may register under HST.162, P/D/F. Enrollment limited, preference to HST students.

true

Fall

Graduate

2-0-4

Permission of instructor

null

false

False

HST.164

Principles of Biomedical Imaging

Reviews fundamental principles and techniques underlying modern biomedical imaging, as well as their application in modern medicine. Particular emphasis on magnetic resonance; also covers ultrasound, computed tomography, positron emission tomography and optical techniques. Didactic lectures accompanied by problem sets and experiments with portable magnetic resonance systems and ultrasound systems. Focuses on the quantitative aspects of biomedical imaging and requires a knowledge of differential equations, MATLAB, and intermediate-level physics. Only HST students may register under HST.164, P/D/F. Restricted to HST students.

true

IAP

Graduate

2-0-4 [P/D/F]

Permission of instructor

null

false

False

HST.165

Principles of Biomedical Imaging

Reviews fundamental principles and techniques underlying modern biomedical imaging, as well as their application in modern medicine. Particular emphasis on magnetic resonance; also covers ultrasound, computed tomography, positron emission tomography and optical techniques. Didactic lectures accompanied by problem sets and experiments with portable magnetic resonance systems and ultrasound systems. Focuses on the quantitative aspects of biomedical imaging and requires a knowledge of differential equations, MATLAB, and intermediate-level physics. Only HST students may register under HST.164, P/D/F. Restricted to HST students.

true

IAP

Graduate

2-0-4

Permission of instructor

null

false

False

HST.175

Cellular and Molecular Immunology

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Limited to 45.

true

Fall

Graduate

6-0-6 [P/D/F]

7.05

null

false

False

HST.176

Cellular and Molecular Immunology

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Only HST students may register under HST.175, graded P/D/F. Limited to 45.

true

Fall

Graduate

6-0-6

7.05

null

false

False

HST.191

Introduction to Biostatistics

Provides training in the use of statistics to comprehend, reason about, and communicate findings from the biomedical sciences, with an emphasis on critical reading of studies published in the literature. Considers assessment of the importance of chance in the interpretation of experimental data from randomized studies and clinical trials. Topics surveyed include basic probability theory; approximate and exact inferential methods such as chi-squared and t-tests, ANOVA, and their permutation-based analogues; linear and generalized linear regression models; survival analysis; causal inference; and statistical data analysis using high-level programming languages such as R. Enrollment restricted to students in the HST program.

true

Summer, IAP, Spring

Graduate

3-0-3

Calculus II (GIR)

null

false

False

HST.192

Medical Decision Analysis and Probabilistic Medical Inference

Teaches the essentials of quantitative diagnostic reasoning and medical decision analysis. Guides participants through the process of choosing an appropriate contemporary medical problem in which risk-benefit tradeoffs play a prominent role, conducting a decision analysis, and ultimately publishing the results in a medical journal. Topics include decision trees, influence diagrams, Markov decision models and Monte Carlo simulation, methods for quantifying patient values, Bayesian inference, decision thresholds, and the cognitive science of medical decision making. HST.191 recommended. Limited to 8; preference to HST students.

true

IAP

Graduate

2-0-2 [P/D/F]

Permission of instructor

null

false

False

HST.195

Clinical Epidemiology

Introduces methods for the generation, analysis, and interpretation of data for clinical research. Major topics include the design of surveys, predictive models, randomized trials, clinical cohorts, and analyses of electronic health records. Prepares students to formulate well-defined research questions, design data collection, evaluate algorithms for clinical prediction, design studies for causal inference, and identify and prevent biases in clinical research. Emphasizes critical thinking and practical applications, including daily assignments based on articles published in major clinical journals and the discussion of a case study each week. Trains students to comprehend, critique, and communicate findings from the biomedical literature. Familiarity with regression modeling and basic statistical theory is a prerequisite. Only HST students may register under HST.194, graded P/D/F. Enrollment limited; restricted to medical and graduate students.

true

IAP, Spring

Graduate

1-0-1

HST.190

null

false

False

HST.196

Teaching Health Sciences and Technology

Provides teaching experience (classroom, laboratory, field, recitation, tutorial) under the direction of faculty member(s). Students may prepare instructional materials, lead discussion groups, provide individualized instruction, monitor students' progress, and gain experience delivering other educational elements. Limited to qualified graduate students.

true

Fall, IAP, Spring, Summer

Graduate

rranged [P/D/F]

null

false

False

HST.198

Independent Study in Health Sciences and Technology

Opportunity for independent study of health sciences and technology under regular supervision by an HST faculty member. Projects require prior approval from the HST Academic Office, as well as a substantive paper.

true

Fall, IAP, Spring, Summer

Graduate

rranged

Permission of instructor

null

false

False

HST.200

Introduction to Clinical Medicine

Intensive preparation for clinical clerkships that introduces the basic skills involved in examination of the patient in addition to history taking and the patient interview. Provides exposure to clinical problems in medicine, surgery, and pediatrics. Students report their findings through history taking and oral presentations. Restricted to MD program students.

true

IAP, Spring

Graduate

9-19-12 [P/D/F]

Permission of instructor

null

false

False

HST.201

Introduction to Clinical Medicine and Medical Engineering I

Develop skills in patient interviewing and physical examination; become proficient at organizing and communicating clinical information in both written and oral forms; begin integrating history, physical, and laboratory data with pathophysiologic principles; and become familiar with the clinical decision-making process and broad economic, ethical, and sociological issues involved in patient care. There are two sections: one at Mount Auburn Hospital and one at West Roxbury VA Hospital, subsequent registration into HST.202 must be continued at the same hospital as HST.201. Restricted to MEMP students.

true

Summer

Graduate

0-20-0 [P/D/F]

Permission of instructor

null

false

False

HST.202

Introduction to Clinical Medicine and Medical Engineering II

Strengthens the skills developed in HST.201 through a six-week clerkship in medicine at a Harvard-affiliated teaching hospital. Students serve as full-time members of a ward team and participate in longitudinal patient care. In addition, students participate in regularly scheduled teaching conferences focused on principles of patient management. Restricted to MEMP students.

true

Fall, IAP, Spring, Summer

Graduate

0-20-0 [P/D/F]

HST.201

null

false

False

HST.207

Introduction to Clinical Medicine and Medical Engineering

Introduction to the intricacies of clinical decision-making through broad exposure to how clinicians think and work in teams. Instruction provided in patient interviewing and physical examination; organizing and communicating clinical information in written and oral forms; and integrating history, physical, and laboratory data with pathophysiologic principles. Attention to the economic, ethical, and sociological issues involved in patient care. Consists of immersive clinical experiences at Massachusetts General Hospital, leveraging extensive educational resources across inpatient clinical floors, ambulatory clinics, procedural/surgical suites, diagnostic testing areas, simulation learning lab, and didactic settings, followed by a focused experience in which students develop a proposal to solve an unmet need identified during their clinical experiences. Equivalent to combination of HST.201 and HST.202. Restricted to HST MEMP students.

true

Spring

Graduate

0-30-0 [P/D/F]

Permission of instructor

null

false

False

HST.220

Introduction to the Care of Patients

Provides an introduction to the care of patients through opportunities to observe and participate in doctor-patient interaction in clinical settings and a longitudinal preceptorship experience with HST alumni physicians. Students are exposed to some of the practical realities of providing patient care. Topics include basic interviewing; issues of ethics, bias, and confidentiality; and other aspects of the doctor-patient relationship. The introductory session is held at HMS or Massachusetts General Hospital and the preceptorships are at several Harvard hospitals in Boston. Requirements include attendance at the introductory session and meetings scheduled with the preceptor.

true

Spring

Graduate

1-0-2 [P/D/F]

Permission of instructor

null

false

False

HST.240

Translational Medicine Preceptorship

Individually designed preceptorship joins together scientific research and clinical medicine. Students devote approximately half of their time to clinical experiences, and the remaining part to scholarly work in basic or clinical science. The two might run concomitantly or in series. Follow a clinical preceptor's daily activity, including aspects of patient care, attending rounds, conferences, and seminars. Research involves formal investigation of a focused and directed issue related to selected clinical area. Final paper required. Limited to students in the GEMS Program.

true

Fall, Spring, Summer

Graduate

0-12-0

HST.035

null

false

False

HST.420[J]

Principles and Practice of Assistive Technology

Students work closely with people with disabilities to develop assistive and adaptive technologies that help them live more independently. Covers design methods and problem-solving strategies; human factors; human-machine interfaces; community perspectives; social and ethical aspects; and assistive technology for motor, cognitive, perceptual, and age-related impairments. Prior knowledge of one or more of the following areas useful: software; electronics; human-computer interaction; cognitive science; mechanical engineering; control; or MIT hobby shop, MIT PSC, or other relevant independent project experience. Enrollment may be limited.

true

Fall

Undergraduate

2-4-6

Permission of instructor

2.78[J], 6.4530[J]

false

False

HST.431[J]

Infections and Inequalities: Interdisciplinary Perspectives on Global Health

Examines case studies in infectious disease outbreaks to demonstrate how human health is a product of multiple determinants, such as biology, sociocultural and historical factors, politics, economic processes, and the environment. Analyzes how structural inequalities render certain populations vulnerable to illness and explores the moral and ethical dimensions of public health and clinical interventions to promote health. Limited to 25.

true

Spring

Undergraduate

3-0-9

null

11.134[J]

false

False

Social Sciences

False

HST.434

Evolution of an Epidemic (Study Abroad)

Examines the medical, scientific, public health and policy responses to a new disease, by focusing on the evolution of the AIDS epidemic. Begins with a review of how this new disease was first detected in the US and Africa, followed by the scientific basis as to how HIV causes profound dysfunction of the body's immune defense mechanisms, the rational development of drugs, the challenge of an HIV vaccine, and how public health and policy decisions have influenced the course of the global epidemic. Class conducted in Johannesburg Durban, South Africa. Open to all majors. Limited to 20. Application required; see class website for eligibility details.

true

IAP

Undergraduate

3-0-1 [P/D/F]

null

false

False

HST.438[J]

Viruses, Pandemics, and Immunity

Covers the history of infectious diseases, basics of virology, immunology, and epidemiology, and ways in which diagnostic tests, vaccines, and antiviral therapies are currently designed and manufactured. Examines the origins of inequities in infection rates in society, and issues pertinent to vaccine safety. Final project explores how to create a more pandemic-resilient world. Subject can count toward the 6-unit discovery-focused credit limit for first-year students. Preference to first-year students; all others should take HST.439.

true

Spring

Undergraduate

2-0-1

null

5.002[J], 10.380[J]

false

False

HST.439[J]

Viruses, Pandemics, and Immunity

Covers the history of infectious diseases, basics of virology, immunology, and epidemiology, and ways in which diagnostic tests, vaccines, and antiviral therapies are currently designed and manufactured. Examines the origins of inequities in infection rates in society, and issues pertinent to vaccine safety. Final project explores how to create a more pandemic-resilient world. HST.438 intended for first-year students; all others should take HST.439.

true

Spring

Undergraduate

2-0-1

null

5.003[J], 8.245[J], 10.382[J]

false

False

HST.450[J]

Biological Physics

Designed to provide seniors and first-year graduate students with a quantitative, analytical understanding of selected biological phenomena. Topics include experimental and theoretical basis for the phase boundaries and equation of state of concentrated protein solutions, with application to diseases such as sickle cell anemia and cataract. Protein-ligand binding and linkage and the theory of allosteric regulation of protein function, with application to proteins as stores as transporters in respiration, enzymes in metabolic pathways, membrane receptors, regulators of gene expression, and self-assembling scaffolds. The physics of locomotion and chemoreception in bacteria and the biophysics of vision, including the theory of transparency of the eye, molecular basis of photo reception, and the detection of light as a signal-to-noise discrimination.

true

Spring

Graduate

4-0-8

8.044 recommended but not necessary

8.593[J]

false

False

HST.452[J]

Statistical Physics in Biology

A survey of problems at the interface of statistical physics and modern biology: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, phylogenetic trees. Physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, elements of protein folding. Considerations of force, motion, and packaging; protein motors, membranes. Collective behavior of biological elements; cellular networks, neural networks, and evolution.

false

Fall

Graduate

3-0-9

8.333 or permission of instructor

8.592[J]

false

False

HST.460[J]

Statistics for Neuroscience Research

A survey of statistical methods for neuroscience research. Core topics include introductions to the theory of point processes, the generalized linear model, Monte Carlo methods, Bayesian methods, multivariate methods, time-series analysis, spectral analysis and state-space modeling. Emphasis on developing a firm conceptual understanding of the statistical paradigm and statistical methods primarily through analyses of actual experimental data.

true

Spring

Graduate

3-0-9

Permission of instructor

9.073[J]

false

False

HST.482[J]

Biomedical Signal and Image Processing

Fundamentals of digital signal processing with emphasis on problems in biomedical research and clinical medicine. Basic principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. Lab projects, performed in MATLAB, provide practical experience in processing physiological data, with examples from cardiology, speech processing, and medical imaging. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the biological signals processed in the labs. Students taking graduate version complete additional assignments.

true

Spring

Undergraduate

3-1-8

(6.3700 or permission of instructor) and (2.004, 6.3000, 16.002, or 18.085)

6.8801[J]

false

False

HST.500

Frontiers in (Bio)Medical Engineering and Physics

Provides a framework for mapping research topics at the intersection of medicine and engineering/physics in the Harvard-MIT community and covers the different research areas in MEMP (for example, regenerative biomedical technologies, biomedical imaging and biooptics). Lectures provide fundamental concepts and consider what's hot, and why, in each area. Training in scientific proposal writing (thesis proposals, fellowship applications, or research grant applications) through writing workshops. Topics include how to structure a novel research project, how to position research within the scientific community, how to present preliminary data effectively, and how to give and respond to peer reviews.

true

Spring

Graduate

3-0-9

null

false

False

HST.504[J]

Topics in Computational Molecular Biology

Covers current research topics in computational molecular biology. Recent research papers presented from leading conferences such as the International Conference on Computational Molecular Biology (RECOMB) and the Conference on Intelligent Systems for Molecular Biology (ISMB). Topics include original research (both theoretical and experimental) in comparative genomics, sequence and structure analysis, molecular evolution, proteomics, gene expression, transcriptional regulation, biological networks, drug discovery, and privacy. Recent research by course participants also covered. Participants will be expected to present individual projects to the class.

true

Fall

Graduate

3-0-9

6.8701, 18.417, or permission of instructor

18.418[J]

false

False

HST.506[J]

Computational Systems Biology: Deep Learning in the Life Sciences

Presents innovative approaches to computational problems in the life sciences, focusing on deep learning-based approaches with comparisons to conventional methods. Topics include protein-DNA interaction, chromatin accessibility, regulatory variant interpretation, medical image understanding, medical record understanding, therapeutic design, and experiment design (the choice and interpretation of interventions). Focuses on machine learning model selection, robustness, and interpretation. Teams complete a multidisciplinary final research project using TensorFlow or other framework. Provides a comprehensive introduction to each life sciences problem, but relies upon students understanding probabilistic problem formulations. Students taking graduate version complete additional assignments.

false

Spring

Graduate

3-0-9

Biology (GIR) and (6.3700 or 18.600)

6.8710[J]

false

False

HST.507[J]

Advanced Computational Biology: Genomes, Networks, Evolution

See description for 6.8701. Additionally examines recent publications in the areas covered, with research-style assignments. A more substantial final project is expected, which can lead to a thesis and publication.

true

Fall

Graduate

4-0-8

(Biology (GIR), 6.1210, and 6.3700) or permission of instructor

6.8700[J]

false

False

HST.508[J]

Evolutionary and Quantitative Genomics

Develops deep quantitative understanding of basic forces of evolution, molecular evolution, genetic variations and their dynamics in populations, genetics of complex phenotypes, and genome-wide association studies. Applies these foundational concepts to cutting-edge studies in epigenetics, gene regulation and chromatin; cancer genomics and microbiomes. Modules consist of lectures, journal club discussions of high-impact publications, and guest lectures that provide clinical correlates. Homework assignments and final projects develop practical experience and understanding of genomic data from evolutionary principles.

true

Fall

Graduate

4-0-8

Permission of instructor

1.872[J]

false

False

HST.515[J]

Aerospace Biomedical and Life Support Engineering

Fundamentals of human performance, physiology, and life support impacting engineering design and aerospace systems. Topics include effects of gravity on the muscle, skeletal, cardiovascular, and neurovestibular systems; human/pilot modeling and human/machine design; flight experiment design; and life support engineering for extravehicular activity (EVA). Case studies of current research are presented. Assignments include a design project, quantitative homework sets, and quizzes emphasizing engineering and systems aspects.

true

Spring

Graduate

3-0-9

16.06, 16.400, or permission of instructor

16.423[J], IDS.337[J]

false

False

HST.518[J]

Human Systems Engineering

Provides a fundamental understanding of human factors that must be taken into account in the design and engineering of complex aviation, space, and medical systems. Focuses primarily on derivation of human engineering design criteria from sensory, motor, and cognitive sources. Includes principles of displays, controls and ergonomics, manual control, the nature of human error, basic experimental design, and human-computer interaction in supervisory control settings. Students taking graduate version complete a research project with a final written report and oral presentation.

true

Fall

Graduate

3-0-9

6.3700, 16.09, or permission of instructor

16.453[J]

false

False

HST.522[J]

Biomaterials: Tissue Interactions

Principles of materials science and cell biology underlying the development and implementation of biomaterials for the fabrication of medical devices/implants, including artificial organs and matrices for tissue engineering and regenerative medicine. Employs a conceptual model, the "unit cell process for analysis of the mechanisms underlying wound healing and tissue remodeling following implantation of biomaterials/devices in various organs, including matrix synthesis, degradation, and contraction. Methodology of tissue and organ regeneration. Discusses methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.

true

Fall

Graduate

3-0-9

(Biology (GIR), Chemistry (GIR), and Physics I (GIR)) or permission of instructor

2.79[J]

false

False

HST.523[J]

Cell-Matrix Mechanics

Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.

true

Fall

Graduate

3-0-9

(Biology (GIR), Chemistry (GIR), and 2.001) or permission of instructor

2.785[J]

false

False

HST.524[J]

Design of Medical Devices and Implants

Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants.

true

Spring

Graduate

3-0-9

(Biology (GIR), Chemistry (GIR), and Physics I (GIR)) or permission of instructor

2.782[J]

false

False

HST.525[J]

Tumor Microenvironment and Immuno-Oncology: A Systems Biology Approach

Provides theoretical background to analyze and synthesize the most up-to-date findings from both laboratory and clinical investigations into solid tumor pathophysiology. Covers different topics centered on the critical role that the tumor microenvironment plays in the growth, invasion, metastasis and treatment of solid tumors. Develops a systems-level, quantitative understanding of angiogenesis, extracellular matrix, metastatic process, delivery of drugs and immune cells, and response to conventional and novel therapies, including immunotherapies. Discussions provide critical comments on the challenges and the future opportunities in research on cancer and in establishment of novel therapeutic approaches and biomarkers to guide treatment.

false

Fall

Graduate

2-0-4

null

10.548[J]

false

False