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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: RESULTS : For the 60 patients who completed phase A , standard - dose haloperidol was efficacious and superior to both low - dose haloperidol and placebo for scores on the Brief Psychiatric Rating Scale psychosis factor and on psychomotor agitation .
### Output Text: | RESULTS : For the 60 patients who completed phase A , standard - dose <span class="chemical">haloperidol</span> was efficacious and superior to both low - dose <span class="chemical">haloperidol</span> and placebo for scores on the Brief Psychiatric Rating Scale psychosis factor and on psychomotor agitation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Response rates according to three sets of criteria were greater with the standard dose ( 55 % - 60 % ) than the low dose ( 25 % - 35 % ) and placebo ( 25 % - 30 % ) .
### Output Text: | Response rates according to three sets of criteria were greater with the standard dose ( 55 % - 60 % ) than the low dose ( 25 % - 35 % ) and placebo ( 25 % - 30 % ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The advantage of standard dose over low dose was replicated in phase B .
### Output Text: | The advantage of standard dose over low dose was replicated in phase B . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In phase A , extrapyramidal signs tended to be greater with the standard dose than in the other two conditions , primarily because of a subgroup ( 20 % ) who developed moderate to severe signs .
### Output Text: | In phase A , extrapyramidal signs tended to be greater with the standard dose than in the other two conditions , primarily because of a subgroup ( 20 % ) who developed moderate to severe signs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Low - dose haloperidol did not differ from placebo on any measure of efficacy or side effects .
### Output Text: | Low - dose <span class="chemical">haloperidol</span> did not differ from placebo on any measure of efficacy or side effects . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: CONCLUSIONS : The results indicated a favorable therapeutic profile for haloperidol in doses of 2 - 3 mg / day , although a subgroup developed moderate to severe extrapyramidal signs .
### Output Text: | CONCLUSIONS : The results indicated a favorable therapeutic profile for <span class="chemical">haloperidol</span> in doses of 2 - 3 mg / day , although a subgroup developed moderate to severe extrapyramidal signs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: A starting dose of 1 mg / day with gradual , upward dose titration is recommended .
### Output Text: | A starting dose of 1 mg / day with gradual , upward dose titration is recommended . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The narrow therapeutic window observed with haloperidol may also apply to other neuroleptics used in Alzheimer ' s disease patients with psychosis and disruptive behaviors .
### Output Text: | The narrow therapeutic window observed with <span class="chemical">haloperidol</span> may also apply to other neuroleptics used in Alzheimer ' s disease patients with psychosis and disruptive behaviors . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Effects of acetylsalicylic acid , dipyridamole , and hydrocortisone on epinephrine - induced myocardial injury in dogs .
### Output Text: | Effects of <span class="chemical">acetylsalicylic acid</span> , <span class="chemical">dipyridamole</span> , and <span class="chemical">hydrocortisone</span> on <span class="chemical">epinephrine</span> - induced myocardial injury in dogs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: A reproducible model for producing diffuse myocardial injury ( epinephrine infusion ) has been developed to study the cardioprotective effects of agents or maneuvers which might alter the evolution of acute myocardial infarction .
### Output Text: | A reproducible model for producing diffuse myocardial injury ( <span class="chemical">epinephrine</span> infusion ) has been developed to study the cardioprotective effects of agents or maneuvers which might alter the evolution of acute myocardial infarction . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Infusions of epinephrine ( 4 mug per kilogram per minute for 6 hours ) increased radiocalcium uptakes into intact myocardium and each of its subcellular components with the mitochondrial fraction showing the most consistent changes when compared to saline - infused control animals ( 4 , 957 vs . 827 counts per minute per gram of dried tissue or fraction ) .
### Output Text: | Infusions of <span class="chemical">epinephrine</span> ( 4 mug per kilogram per minute for 6 hours ) increased <span class="chemical">radiocalcium</span> uptakes into intact myocardium and each of its subcellular components with the mitochondrial fraction showing the most consistent changes when compared to saline - infused control animals ( 4 , 957 vs . 827 counts per minute per gram of dried tissue or fraction ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Myocardial concentrations of calcium also increased significantly ( 12 . 0 vs . 5 . 0 mg . per 100 Gm . of fat - free dry weight ) .
### Output Text: | Myocardial concentrations of <span class="chemical">calcium</span> also increased significantly ( 12 . 0 vs . 5 . 0 mg . per 100 Gm . of fat - free dry weight ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Infusions of calcium chloride sufficient to raise serum calcium concentrations 2 mEq . per liter failed to increase calcium influx into the myocardial cell .
### Output Text: | Infusions of <span class="chemical">calcium chloride</span> sufficient to raise serum <span class="chemical">calcium</span> concentrations 2 mEq . per liter failed to increase <span class="chemical">calcium</span> influx into the myocardial cell . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mitochondrial radiocalcium uptakes were significantly decreased in animals pretreated with acetylsalicylic acid or dipyridamole or when hydrocortisone was added to the epinephrine infusion ( 2 , 682 , 2 , 803 , and 3 , 424 counts per minute per gram of dried fraction , respectively ) .
### Output Text: | Mitochondrial <span class="chemical">radiocalcium</span> uptakes were significantly decreased in animals pretreated with <span class="chemical">acetylsalicylic acid</span> or <span class="chemical">dipyridamole</span> or when <span class="chemical">hydrocortisone</span> was added to the <span class="chemical">epinephrine</span> infusion ( 2 , 682 , 2 , 803 , and 3 , 424 counts per minute per gram of dried fraction , respectively ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Myocardial calcium concentrations also were decreased ( 11 . 2 , 8 . 3 , and 8 . 9 mg . per 100 Gm . of fat - free dry weight , respectively ) in the three treatment groups , being significantly decreased only in the last two .
### Output Text: | Myocardial <span class="chemical">calcium</span> concentrations also were decreased ( 11 . 2 , 8 . 3 , and 8 . 9 mg . per 100 Gm . of fat - free dry weight , respectively ) in the three treatment groups , being significantly decreased only in the last two . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Evidence of microscopic damage was graded as less severe in the three treatment groups .
### Output Text: | Evidence of microscopic damage was graded as less severe in the three treatment groups . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Acetylsalicylic acid , dipyridamole , and hydrocortisone all appear to have cardioprotective effects when tested in this model .
### Output Text: | <span class="chemical">Acetylsalicylic acid</span> , <span class="chemical">dipyridamole</span> , and <span class="chemical">hydrocortisone</span> all appear to have cardioprotective effects when tested in this model . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Clinical and histopathologic examination of renal allografts treated with tacrolimus ( FK506 ) for at least one year .
### Output Text: | Clinical and histopathologic examination of renal allografts treated with <span class="chemical">tacrolimus</span> ( <span class="chemical">FK506</span> ) for at least one year . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: BACKGROUND : We clinically and pathologically analyzed renal allografts from 1 9 renal transplant patients treated with tacrolimus ( FK506 ) for more than 1 year .
### Output Text: | BACKGROUND : We clinically and pathologically analyzed renal allografts from 1 9 renal transplant patients treated with <span class="chemical">tacrolimus</span> ( <span class="chemical">FK506</span> ) for more than 1 year . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: METHODS : Twenty - six renal allograft biopsy specimens from 1 9 renal transplant patients who underwent transplantations between 1991 and 1993 were evaluated .
### Output Text: | METHODS : Twenty - six renal allograft biopsy specimens from 1 9 renal transplant patients who underwent transplantations between 1991 and 1993 were evaluated . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Thirteen biopsies were performed from stable functioning renal allografts with informed consent ( nonepisode biopsy ) and the other 13 were from dysfunctional renal allografts with a clinical indication for biopsy ( episode biopsy ) .
### Output Text: | Thirteen biopsies were performed from stable functioning renal allografts with informed consent ( nonepisode biopsy ) and the other 13 were from dysfunctional renal allografts with a clinical indication for biopsy ( episode biopsy ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: RESULTS : The main pathologic diagnoses ( some overlap ) were acute rejection ( AR ; n = 4 ) , chronic rejection ( CR ; n = 5 ) , AR + CR ( n = 4 ) , recurrent IgA nephropathy ( n = 5 ) , normal findings ( n = 2 ) , minimal - type chronic FK506 nephropathy ( n = 9 ) , and mild - type FK506 nephropathy ( n = 11 ) .
### Output Text: | RESULTS : The main pathologic diagnoses ( some overlap ) were acute rejection ( AR ; n = 4 ) , chronic rejection ( CR ; n = 5 ) , AR + CR ( n = 4 ) , recurrent IgA nephropathy ( n = 5 ) , normal findings ( n = 2 ) , minimal - type chronic <span class="chemical">FK506</span> nephropathy ( n = 9 ) , and mild - type <span class="chemical">FK506</span> nephropathy ( n = 11 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Of the nonepisode biopsies , 7 and 4 biopsies showed minimal - type and mild - type chronic FK506 nephropathy , respectively .
### Output Text: | Of the nonepisode biopsies , 7 and 4 biopsies showed minimal - type and mild - type chronic <span class="chemical">FK506</span> nephropathy , respectively . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Chronic FK506 nephropathy consisted of rough and foamy tubular vacuolization ( 5 biopsies ) , arteriolopathy ( angiodegeneration of the arteriolar wall ; 20 biopsies ) , focal segmental glomerulosclerosis ( 4 biopsies ) and the striped form of interstitial fibrosis ( 11 biopsies ) .
### Output Text: | Chronic <span class="chemical">FK506</span> nephropathy consisted of rough and foamy tubular vacuolization ( 5 biopsies ) , arteriolopathy ( angiodegeneration of the arteriolar wall ; 20 biopsies ) , focal segmental glomerulosclerosis ( 4 biopsies ) and the striped form of interstitial fibrosis ( 11 biopsies ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The serum creatinine levels of patients in the mild - type chronic FK506 nephropathy group , which included 7 episode biopsies , were statistically higher than those in the minimum - type chronic FK506 - nephropathy group ( P < 0 . 001 ) .
### Output Text: | The serum <span class="chemical">creatinine</span> levels of patients in the mild - type chronic <span class="chemical">FK506</span> nephropathy group , which included 7 episode biopsies , were statistically higher than those in the minimum - type chronic <span class="chemical">FK506</span> - nephropathy group ( P < 0 . 001 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: CONCLUSIONS : This study demonstrates that chronic FK506 nephropathy consists primarily of arteriolopathy manifesting as insudative hyalinosis of the arteriolar wall , and suggests that mild - type chronic FK506 nephropathy is a condition which may lead to deterioration of renal allograft function .
### Output Text: | CONCLUSIONS : This study demonstrates that chronic <span class="chemical">FK506</span> nephropathy consists primarily of arteriolopathy manifesting as insudative hyalinosis of the arteriolar wall , and suggests that mild - type chronic <span class="chemical">FK506</span> nephropathy is a condition which may lead to deterioration of renal allograft function . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis .
### Output Text: | Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Hepatocyte tight junctions ( TJs ) , the only intercellular barrier between the sinusoidal and the canalicular spaces , play a key role in bile formation .
### Output Text: | Hepatocyte tight junctions ( TJs ) , the only intercellular barrier between the sinusoidal and the canalicular spaces , play a key role in bile formation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Although hepatocyte TJs are impaired in cholestasis , attempts to localize the precise site of hepatocyte TJ damage by freeze - fracture electron microscopy have produced limited information .
### Output Text: | Although hepatocyte TJs are impaired in cholestasis , attempts to localize the precise site of hepatocyte TJ damage by freeze - fracture electron microscopy have produced limited information . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Recently , several TJ - associated proteins like ZO - 1 and 7H6 have been identified and characterized .
### Output Text: | Recently , several TJ - associated proteins like ZO - 1 and 7H6 have been identified and characterized . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Immunolocalization of 7H6 appears to closely correlate with paracellular permeability .
### Output Text: | Immunolocalization of 7H6 appears to closely correlate with paracellular permeability . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: We used rat models of intrahepatic cholestasis by ethinyl estradiol ( EE ) treatment and extrahepatic cholestasis by bile duct ligation ( BDL ) to precisely determine the site of TJ damage .
### Output Text: | We used rat models of intrahepatic cholestasis by <span class="chemical">ethinyl estradiol</span> ( <span class="chemical">EE</span> ) treatment and extrahepatic cholestasis by bile duct ligation ( BDL ) to precisely determine the site of TJ damage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Alterations in hepatocyte TJs were assessed by double - immunolabeling for 7H6 and ZO - 1 using a confocal laser scanning microscope .
### Output Text: | Alterations in hepatocyte TJs were assessed by double - immunolabeling for 7H6 and ZO - 1 using a confocal laser scanning microscope . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In control rats , immunostaining for 7H6 and ZO - 1 colocalized to outline bile canaliculi in a continuous fashion .
### Output Text: | In control rats , immunostaining for 7H6 and ZO - 1 colocalized to outline bile canaliculi in a continuous fashion . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In contrast , 7H6 and ZO - 1 immunostaining was more discontinuous , outlining the bile canaliculi after BDL .
### Output Text: | In contrast , 7H6 and ZO - 1 immunostaining was more discontinuous , outlining the bile canaliculi after BDL . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Immunostaining for 7H6 , not ZO - 1 , decreased and predominantly appeared as discrete signals in the submembranous cytoplasm of periportal hepatocytes after BDL .
### Output Text: | Immunostaining for 7H6 , not ZO - 1 , decreased and predominantly appeared as discrete signals in the submembranous cytoplasm of periportal hepatocytes after BDL . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: After EE treatment , changes in immunostaining for 7H6 and ZO - 1 were similar to those seen in periportal hepatocytes after BDL , but distributed more diffusely throughout the lobule .
### Output Text: | After <span class="chemical">EE</span> treatment , changes in immunostaining for 7H6 and ZO - 1 were similar to those seen in periportal hepatocytes after BDL , but distributed more diffusely throughout the lobule . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: This study is the first to demonstrate that impairment of hepatocyte TJs occurs heterogenously in the liver lobule after BDL and suggests that BDL and EE treatments produce different lobular distributions of increased paracellular permeability .
### Output Text: | This study is the first to demonstrate that impairment of hepatocyte TJs occurs heterogenously in the liver lobule after BDL and suggests that BDL and <span class="chemical">EE</span> treatments produce different lobular distributions of increased paracellular permeability . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the acetylcholine releaser PG - 9 .
### Output Text: | Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the <span class="chemical">acetylcholine</span> releaser <span class="chemical">PG - 9</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The effects of PG - 9 ( 3alpha - tropyl 2 - ( p - bromophenyl ) propionate ) , the acetylcholine releaser , on memory processes and nerve growth factor ( NGF ) synthesis were evaluated .
### Output Text: | The effects of <span class="chemical">PG - 9</span> ( <span class="chemical">3alpha - tropyl 2 - ( p - bromophenyl ) propionate</span> ) , the <span class="chemical">acetylcholine</span> releaser , on memory processes and nerve growth factor ( NGF ) synthesis were evaluated . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In the mouse passive - avoidance test , PG - 9 ( 10 - 30 mg / kg , i . p . ) , administered 20 min before the training session , prevented amnesia induced by both the non selective antimuscarinic drug scopolamine and the M1 - selective antagonist S - ( - ) - ET - 126 .
### Output Text: | In the mouse passive - avoidance test , <span class="chemical">PG - 9</span> ( 10 - 30 mg / kg , i . p . ) , administered 20 min before the training session , prevented amnesia induced by both the non selective antimuscarinic drug <span class="chemical">scopolamine</span> and the M1 - selective antagonist <span class="chemical">S - ( - ) - ET - 126</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In the same experimental conditions , PG - 9 ( 5 - 20 microg per mouse , i . c . v . ) was also able to prevent antimuscarine - induced amnesia , demonstrating a central localization of the activity .
### Output Text: | In the same experimental conditions , <span class="chemical">PG - 9</span> ( 5 - 20 microg per mouse , i . c . v . ) was also able to prevent antimuscarine - induced amnesia , demonstrating a central localization of the activity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: At the highest effective doses , PG - 9 did not produce any collateral symptoms as revealed by the Irwin test , and it did not modify spontaneous motility and inspection activity , as revealed by the hole - board test .
### Output Text: | At the highest effective doses , <span class="chemical">PG - 9</span> did not produce any collateral symptoms as revealed by the Irwin test , and it did not modify spontaneous motility and inspection activity , as revealed by the hole - board test . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: PG - 9 was also able to increase the amount of NGF secreted in vitro by astrocytes in a dose - dependent manner .
### Output Text: | <span class="chemical">PG - 9</span> was also able to increase the amount of NGF secreted in vitro by astrocytes in a dose - dependent manner . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The maximal NGF contents obtained by PG - 9 were 17 . 6 - fold of the control value .
### Output Text: | The maximal NGF contents obtained by <span class="chemical">PG - 9</span> were 17 . 6 - fold of the control value . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: During culture , no morphological changes were found at effective concentrations of PG - 9 .
### Output Text: | During culture , no morphological changes were found at effective concentrations of <span class="chemical">PG - 9</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The current work indicates the ability of PG - 9 to induce beneficial effects on cognitive processes and stimulate activity of NGF synthesis in astroglial cells .
### Output Text: | The current work indicates the ability of <span class="chemical">PG - 9</span> to induce beneficial effects on cognitive processes and stimulate activity of NGF synthesis in astroglial cells . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Therefore , PG - 9 could represent a potential useful drug able to improve the function of impaired cognitive processes .
### Output Text: | Therefore , <span class="chemical">PG - 9</span> could represent a potential useful drug able to improve the function of impaired cognitive processes . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mechanisms of FK 506 - induced hypertension in the rat .
### Output Text: | Mechanisms of <span class="chemical">FK 506</span> - induced hypertension in the rat . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: - Tacrolimus ( FK 506 ) is a powerful , widely used immunosuppressant .
### Output Text: | - <span class="chemical">Tacrolimus</span> ( <span class="chemical">FK 506</span> ) is a powerful , widely used immunosuppressant . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity .
### Output Text: | The clinical utility of <span class="chemical">FK 506</span> is complicated by substantial hypertension and nephrotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: To clarify the mechanisms of FK 506 - induced hypertension , we studied the chronic effects of FK 506 on the synthesis of endothelin - 1 ( ET - 1 ) , the expression of mRNA of ET - 1 and endothelin - converting enzyme - 1 ( ECE - 1 ) , the endothelial nitric oxide synthase ( eNOS ) activity , and the expression of mRNA of eNOS and C - type natriuretic peptide ( CNP ) in rat blood vessels .
### Output Text: | To clarify the mechanisms of <span class="chemical">FK 506</span> - induced hypertension , we studied the chronic effects of <span class="chemical">FK 506</span> on the synthesis of endothelin - 1 ( ET - 1 ) , the expression of mRNA of ET - 1 and endothelin - converting enzyme - 1 ( ECE - 1 ) , the endothelial <span class="chemical">nitric oxide</span> synthase ( eNOS ) activity , and the expression of mRNA of eNOS and C - type natriuretic peptide ( CNP ) in rat blood vessels . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In addition , the effect of the specific endothelin type A receptor antagonist FR 139317 on FK 506 - induced hypertension in rats was studied .
### Output Text: | In addition , the effect of the specific endothelin type A receptor antagonist <span class="chemical">FR 139317</span> on <span class="chemical">FK 506</span> - induced hypertension in rats was studied . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: FK 506 , 5 mg .
### Output Text: | <span class="chemical">FK 506</span> , 5 mg . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: kg - 1 .
### Output Text: | kg - 1 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: d - 1 given for 4 weeks , elevated blood pressure from 102 + / - 13 to 152 + / - 15 mm Hg and increased the synthesis of ET - 1 and the levels of ET - 1 mRNA in the mesenteric artery ( 240 % and 230 % , respectively ) .
### Output Text: | d - 1 given for 4 weeks , elevated blood pressure from 102 + / - 13 to 152 + / - 15 mm Hg and increased the synthesis of ET - 1 and the levels of ET - 1 mRNA in the mesenteric artery ( 240 % and 230 % , respectively ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Little change was observed in the expression of ECE - 1 mRNA and CNP mRNA .
### Output Text: | Little change was observed in the expression of ECE - 1 mRNA and CNP mRNA . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: FK 506 decreased eNOS activity and the levels of eNOS mRNA in the aorta ( 48 % and 55 % , respectively ) .
### Output Text: | <span class="chemical">FK 506</span> decreased eNOS activity and the levels of eNOS mRNA in the aorta ( 48 % and 55 % , respectively ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The administration of FR 139317 ( 10 mg . kg - 1 . d - 1 ) prevented FK 506 - induced hypertension in rats .
### Output Text: | The administration of <span class="chemical">FR 139317</span> ( 10 mg . kg - 1 . d - 1 ) prevented <span class="chemical">FK 506</span> - induced hypertension in rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These results indicate that FK 506 may increase blood pressure not only by increasing ET - 1 production but also by decreasing NO synthesis in the vasculature .
### Output Text: | These results indicate that <span class="chemical">FK 506</span> may increase blood pressure not only by increasing ET - 1 production but also by decreasing <span class="chemical">NO</span> synthesis in the vasculature . |