databio/term-knowledge · Datasets at Hugging Face

BTO_0001948 stringlengths 11 11	JURKAT E-6.1 cell stringlengths 2 47	Human, blood, leukemia, T cell line, clone E6.1. stringlengths 20 1.28k
EFO_0002831	MKN28	Well differentiated human gastric adenocarcinoma cell line.
EFO_0002832	MKN45	Human gastric adenocarcinoma, established from the poorly differentiated adenocarcinoma of the stomach (medullary type) of a 62-year-old woman.
EFO_0002839	MSTO-211H	Human mesothelioma cell line; established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic) who did not have any prior therapy.
EFO_0002853	RM 82	A cell line derived from human 39 s sarcoma.
EFO_0002854	SBC-3	A cell line derived from human small cell lung carcinoma.
EFO_0002895	MKN7	Well differentiated human gastric adenocarcinoma cell line.
EFO_0002957	2102Ep	2102ep is an embryonal cell line
EFO_0002959	NTera2	A human embryonal carcinoma (EC) stem cell line used as a model system for the study of neuronal differentiation
EFO_0002960	BG03	A human embryonic stem cell line
EFO_0002961	NTera2 derived dopaminergic neuronal like cells	A human embryonal carcinoma (EC) stem cell line used as a model system for the study of neuronal differentiation and differentiated into neuronal like cells
EFO_0003039	EAhy 926 cell	The EAhy 926 cell is a hybridoma line derived from human endothelium and A549/8 cells. They display stable endothelial characteristics and may provide an indication of how endothelial cells respond to photodynamic therapy.
EFO_0003042	H1-hESC	H1 human embryonic stem cell line, usually called H1-hESC and on occasion just H1
EFO_0003045	H9	This human ES cell line expresses cell surface markers specific to undifferentiated nonhuman primate ES and human EC cells: stage-specific embryonic antigen (SSEA)–3, SSEA-4, TRA-l-60, TRA-1- 81, and alkaline phosphatase. It has a normal 46, XX karyotype. Teratomas are formed upon cell injection into SCID mice. These teratomas include cells from all three germ layers. Isolation & Growth Conditions This cell line can be cultured using feeder cells or in a feeder-free protocol. When using feeder cells, human ESC culture medium should be compreised of Advanced DMEM/F12 supplemented with knockout serum replacement (20%), non-essential amino acids (1x), L-glutamine (1x), penicillin/streptomycin (1x), β-mercaptoethanol (1x) and FGF-2 (4 ng/ml). Maintain the human ESCs on Matrigel using hESC medium conditioned by mouse embryonic fibroblasts.
EFO_0003056	M14	The human melanoma cell line M14 has been established from surgically removed melanoma metastases.
EFO_0004389	UCH-1	Human chordoma cell line.
EFO_0004921	GM00038	Apparently health human non-fetal tissue.
EFO_0004922	GM00719	ATAXIA-TELANGIECTASIA; AT
EFO_0005231	ECC-1	An established epithelial cell line derived from an adenocarcinoma of human endometrial lining.
EFO_0005234	PFSK-1	Neuroectodermal cell line derived from a cerebral brain tumor.
EFO_0005236	NT2/D1	The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line. Derived from metastatic site: lung
EFO_0005237	U-87 MG	A human epithelial cell derived from subject with grade IV glioblastoma; astrocytoma.
EFO_0005263	TOV-112D	TOV-112D is a human epithelial cell line initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.
EFO_0005264	Ect1	The ectocervical Ect1/E6E7 (ATCC CRL-2614) and endocervical End1/E6E7 (ATCC CRL-2615) cell lines were established in 1996 from normal epithelial tissue taken from a premenopausal woman undergoing hysterectomy for endometriosis.
EFO_0005265	MOLT-3	MOLT-3 is a male human malignant T-lymphoblastic cell line.
EFO_0005282	HS-5	Established from human bone marrow stromal cells transformed by HPV-16 E6/E7.
EFO_0005283	HS-27A	Established from human bone marrow stromal cells transformed by HPV-16 E6/E7.
EFO_0005355	HUES1	A human embryonic stem cell line
EFO_0005384	HuH-7	HuH-7 is a well differentiated hepatocyte derived cellular carcinoma cell line that was originally taken from a liver tumor in a 57-year-old Japanese male in 1982. The line was established by Nakabayshi, H. and Sato, J. HuH-7 is an immortal cell line of epithelial-like tumorigenic cells. It usually grow in 2D monolayers.
EFO_0005388	JIMT-1	Source : Pleural effusion, Ductal breast cancer (grade 3 invasive, T2N1M0) Karyotype : Highly rearranged hyperdiploid karyotype with 6% polyploidy Carry an amplified HER-2 oncogene and to be insensitive to HER-2-inhibiting drugs
EFO_0005441	DU 145	A cell line derived from human prostate carcinoma. The patient was a 69-year-old male, and the sample was derived from brain metastasis.
EFO_0005445	PEO1	PEO1 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO1 is tumourigenic in immunologically-deprived CBA mice. PEO1 exhibits good growth in semi-solid medium (agar). PEO1 is from the same patient as the PEO4 and PEO6 cell lines (Sigma Catalogue numbers 10032309 & 10032310).This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) available at ECACC which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. (Sigma-Aldrich catalog number 10032308)
EFO_0005696	D721Med	Medulloblastoma (aka D721), surgical resection from a patient with medulloblastoma as described by Darrell Bigner (1997)
EFO_0005697	M059J	M059J cells were isolated from a tumor specimen taken from a 33 year old male with untreated malignant glioblastoma. The cells were isolated concurrently from the same tumor specimen as M059K (see CRL-2365).
EFO_0005698	Daoy	The Daoy cell line was established in 1985 by P. F Jacobsen of the Royal Perth Hospital in Western Australia. The line was derived from biopsy material taken from a tumor in the posterior fossa of a 4 year old boy.
EFO_0005700	TTC549	This is an adherent cell line derived from a hepatic rhabdoid tumor. Hepatic rhabdoid tumors are extremely rare. This cell line has a large deletion on 22q, which indicates numerous genes in addition to SNF5 are deleted.
EFO_0005702	A204.1	A malignant rhabdoid tumor diploid cell population cloned from the A204 ATCC cell line. [PMID: 16897758]
EFO_0005703	G401.6	This is an adherent cell line that represents the prototypical renal rhabdoid tumor [PMID: 16897758]. G401.6 is a diploid, 6-thioguanine-resistant clonal variant of the G401 cell line isolated by Weissman et al., Science, 236:175-180 (1986). The parental cell line, G401, can be ordered from the ATCC (CRL1441).
EFO_0005704	HuH-7.5	HuH-7 is a well differentiated hepatocyte derived cellular carcinoma cell line that was originally taken from a liver tumor in a 57-year-old Japanese male in 1982. The line was established by Nakabayshi, H. and Sato, J. HuH-7 is an immortal cell line of epithelial-like tumorigenic cells. It usually grow in 2D monolayers. HuH7.5 developed from HuH7.
EFO_0005705	olfactory neurosphere cell line	Nasal biopsies were collected from volunteer donors as an outpatient procedure as described (Feron et al., 1998). This was done by a registered otolaryngologist via an endoscopic procedure to ensure biopsy samples were taken from the superior, posterior region of the nasal septum close to the cribriform plate. Pieces of olfactory mucosa were obtained which contain stem cells in the olfactory epithelium. The stem cell population derived from human olfactory mucosa has been described as ecto-mesenchymal (Delorme et al., 2010) because it has characteristics of both neural and mesenchymal stem cells, suggesting a neural crest origin.
EFO_0009494	C1 100080002	Cell line from olfactory neurosphere cells from a 59-year-old human male.
EFO_0009495	C1 100080003	Cell line from olfactory neurosphere cells from a 66-year-old human female.
EFO_0009496	C1 100080013	Cell line from olfactory neurosphere cells from a 64-year-old human male.
EFO_0005706	Mel-2183	in the Surgery Branch of the NCI.">This cell line was from a melanoma metastasis tumor taken from the subcutaneous shoulder of an individual. Cell line was derived by Dr. Yardena Samuels (samuelsy[at]mail.nih.gov)
EFO_0005707	786-0	This line was derived from a primary clear cell adenocarcinoma. The karyotype is hypertriploid; Y was present in 60% the cells examined. The cells display both microvilli and desmosomes, and can be grown in soft agar. The cells produce a PTH like peptides that is identical to peptides produced by breast and lung tumors.
EFO_0005709	HTR8/SVneo	First trimester human trophoblast cells established by immortalizing a physiologic extravillous trophoblast cell via transfection with a plasmid containing the simian virus 40 large T antigen (SV40) (see Graham et al., 1993). Cells are a thin layer of ectoderm that forms the wall of many mammalian blastulas and functions in the nutrition and implantation of the embryo.
EFO_0005710	HFF-Myc	This is an adherent cell line. HFF-Myc are human foreskin fibroblasts containing a virally integrated vector expressing the canine cMyc gene. Cells were received from Dr. Beverly Torok-Storb, Fred Hutchison Cancer Research Center, Seattle, WA.
EFO_0005711	HPDE6-E6E7	Normal benign adult human pancreatic duct cells immortalized with E6E7 gene of HPV-16. HPDE6-E6E7 cells demonstrated a near normal genotype and phenotype of pancreatic duct epithelial cells. [PMC1861644]
EFO_0005712	RPMI-7951	Human skin malignant melanoma cells that can be ordered from ATCC. This is a hyperdiploid human cell line with the modal chromosome number of 49, occurring in 24% of cells. Polyploid cells occurred at 22%, which is high. Cells are adherent, and were first harvested in 1971 from a metastatic site in a lymph node.
EFO_0005713	8988T	Human pancreas adenocarcinoma (PA-TU-8988T), "established in 1985 from the liver metastasis of a primary pancreatic adenocarcinoma from a 64-year-old woman; sister cell line of PA-TU-8988S" - DSMZ.
EFO_0005714	LHCN-M2	Skeletal myoblasts derived from satellite cells from the pectoralis major muscle of a 41 year old caucasian heart transplant donor, immortalized with lox-hygro-hTERT (LH), and Cdk4-neo (CN), Zhu et al. (2007) in Aging Cell, vol. 6, pp 515-523. M2 is an extremely well-differentiating subclone of LHCN (thus "LHCN-M2").
EFO_0005715	WERI-Rb-1	The WERI-Rb-1 line is one of two human retinoblastoma cell lines established in 1974 by R.M. McFall and T.W. Sery. This is a near diploid line. The modal chromosome number is 47 occurring at 38%, and the rate of polyploidy is 9%. Cells are grape-like clusters of round cells in suspension.
EFO_0005718	Ishikawa	"The cell line Ishikawa was established from an endometrial adenocarcinoma of a 39 year old woman. Cells can be commercially obtained from Sigma (99040201-1VL). However, it should be noted that the original source of these cells (M. Nashide, Japan) can spontaneously lose the progesterone and estrogen receptor. For details, see Nishida M., The Ishikawa cells from birth to the present. Hum Cell. 2002 Sep;15(3):104-17."
EFO_0005720	SK-MEL-5	This melanoma cell line was derived from a metastatic axillary node of the skin of a 24 year old female. It is a hyperpentaploid human cell line with the modal chromosome number of 120, occurring in 9% of cells. [PMID: 1067619]
EFO_0005721	SK-N-DZ	SK-N-DZ is a neuroblastoma cell line derived in 1978 from a bone marrow metastasis from a child with poorly differentiated embryonal neuroblastoma.
EFO_0005722	SJRH30	The line was established from cells from the bone marrow of a child with rhabdomyosarcoma. Derived from a metastatic site of the bone marrow. The cells show ultrastructural elements of primitive skeletal muscle differentiation.
EFO_0005723	GM23248	Fibroblasts taken from a skin punch of the arm
EFO_0005724	MM.1S	MM.1S is a B lymphoblast cell line derived in 1986. The parent cell line, MM.1, was established from peripheral blood of a multiple myeloma patient who had become resistant to steroid-based therapy. provide critical information about disease progression and the development of drug resistance. This cell line represents a valuable tool for elucidating the mechanisms of action of glucocorticoids and the development of new therapeutics. [PMID: 2926241]
EFO_0005725	BE(2)-C	BE(2)-C is a clone of the SK-N-BE(2) neuroblastoma cell line (ATCC CRL-2271) that was established in November of 1972 from a bone marrow biopsy taken from child with disseminated neuroblastoma after repeated courses of chemotherapy and radiotherapy. The cells grow as clusters of flattened neuroblastic cells with occasional fine cell processes (neurites). Unlike the parent line, they generally do not detach and float.
EFO_0005726	LNCaP clone FGC	LNCaP clone FGC was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old Caucasian male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma. This is a hypotetraploid human cell line. The modal chromosome number was 84, occurring in 22% of cells. However, cells with chromosome counts of 86 (20%) and 87 (18%) also occurred at high frequencies. These cells are responsive to 5-alpha-dihydrotestosterone (growth modulation and acid phosphatase production).
EFO_0005901	ELF-1	Human embryonic stem cell line ELF-1 was derived from a human embryo in the Ellison Stem Cell Core at the University of Washington, Seattle, WA.
EFO_0005903	KBM-7	KBM-7 cells were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. The original cell line contained both near haploid and hyperdiploid clones. Subsequent subcloning yielded a pure near-haploid cell line.Genome analysis has revealed that besides the disomic chromosome 8 also a 30 megabase fragment of chromosome 15 is present in two copies. Like other CML cells lines (e.g., K562) KBM-7 cells are positive for the Philadelphia chromosome harboring the BCR-ABL oncogenic fusion. KBM-7 cells have been reprogrammed to yield the HAP1 cell line which is also haploid for chromosome 8.
EFO_0007598	HAP-1	HAP1 is a near-haploid human cell line that was derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. HAP1 cells are adherent with fibroblast-like morphology.
EFO_0005904	H7-hESC	Undifferentiated embryonic stem cells
EFO_0005907	OCI-LY1	Established from the bone marrow of a 44-year-old man with B-cell Non-Hodgkin lymphoma (B-NHL; diffuse large cell), stage 4B at relapse in 1983.
EFO_0005909	HGADFN167	Dermal fibroblasts from an 8 year old male with Hutchinson-Gilford progeria syndrome (cell line HGPS, HGADFN167, progeria research foundation).
EFO_0005912	hTERT-HM	An immortalized cell line from hTERT-infected myometrial cells (hTERT-HM). Cells were isolated from myometrial tissue obtained from women undergoing hysterectomy, and retroviral infection was used to express the catalytic subunit of telomerase in myometrial cells.
EFO_0005913	urothelium cell line	Primary ureter cell culture of urothelial cells derived from a 12 year-old girl and immortalized by transfection with a temperature-sensitive SV-40 large T antigen gene.
EFO_0006268	A431	The epidermoid carcinoma cell line A-431, derived from an 85-year-old female, is one of a series of cell lines established from solid tumors by D.J. Giard, et al. This is a hypertriploid human cell line. The modal chromosome number was 74 occurring in 36% of cells. The rate of cells with higher ploidies was 1.0%.
EFO_0006269	ACH-3P	Cell line was established by fusion of primary human first trimester trophoblasts (week 12 of gestation) with a human choriocarcinoma cell line (AC1-1).
EFO_0006270	AG04450	The culture was initiated on 5/20/80 from explants of minced lung tissue taken from a therapeutically aborted fetus of 12 weeks gestational age. The cell morphology is fibroblast-like. The karyotype is 46,XY; normal diploid male. A matched skin-derived fibroblast culture from same fetus is AG04449.
EFO_0006271	ARPE-19	ARPE-19 is a spontaneously arising retinal pigment epithelia (RPE) cell line derived in 1986 by Amy Aotaki-Keen from the normal eyes of a 19-year-old male who died from head trauma in a motor vehicle accident.
EFO_0006276	GM15850	Clinically affected; ataxia; scoliosis; hypertrophic cardiomyopathy; slurred speech; homozygous for the GAA expansion in the frataxin gene with alleles of approximately 650 and 1030 repeats; brother of GM15849 and GM15851, son of GM15847 and GM15848.
EFO_0006277	GM15851	Clinically unaffected;has two FRDA alleles in the normal range of GAA trinucleotide repeats;brother of an affected individual (GM15850).
EFO_0006278	GM5659	GM5659 primary fibroblasts were established from a skin biopsy of an apparently healthy donor
EFO_0006279	HPAF1	Cell line is derived from the normal human parotid gland. The cell lines are propagated in serum-free medium comprised of keratinocyte basal medium supplemented with insulin (5 micrograms/ml), hydrocortisone (0.5 micrograms/ml),epidermal growth factor (EGF, 10 ng/ml), bovine pituitary extract (25 micrograms/ml), and antibiotics. Normal diploid karyotypes, lack transformed phenotypes and non-tumorigenic in nude mice. Produces tissue-specific proteins, i.e. α-amylase 1, basic proline-rich protein, and cystatins; and expressed the corresponding genes as determined by RT-PCR analyses.
EFO_0006280	HPAM1	Cell line is derived from the normal human parotid gland. The cell lines are propagated in serum-free medium comprised of keratinocyte basal medium supplemented with insulin (5 micrograms/ml), hydrocortisone (0.5 micrograms/ml),epidermal growth factor (EGF, 10 ng/ml), bovine pituitary extract (25 micrograms/ml), and antibiotics. Normal diploid karyotypes, lack transformed phenotypes and non-tumorigenic in nude mice. Produces tissue-specific proteins, i.e. α-amylase 1, basic proline-rich protein, and cystatins; and expressed the corresponding genes as determined by RT-PCR analyses.
EFO_0006281	JinB8	CD47-deficient T cell line derived from Jurkat cells (JinB8)
EFO_0006282	KM12	KM12 is one of the cell lines of the NCI-60 panel which represents different cancer types and has been widely utilized for drug screening and molecular target identification.
EFO_0006285	MEC2	Cell line grew spontaneously on two subsequent occasions from the peripheral blood (PB) of a patient with B-chronic lymphocytic leukemia (B-CLL) in prolymphocytoid transformation. The patient was EBV-seropositive, his leukemic cells were EBNA negative, but the spontaneously grown cell lines are EBNA-2 positive. MEC2 cells do not adhere and form large clumps. The doubling time of MEC2 is 31h.
EFO_0006287	Mono Mac 6	A monocytic cell line, termed Mono Mac, was established from peripheral blood of a patient with monoblastic leukemia. Two clones, designated Mono Mac I and Mono Mac 6, were isolated and both were assigned to the monocyte lineage on the basis of morphological, cytochemical and immunological criteria. Most importantly, the clones express NaF-sensitive non-specific-esterase, produce reactive oxygen and stain with MAb My4. Mono Mac 6, in addition, constitutively exhibits phagocytosis of antibody-coated erythrocytes in 80% of the cells and reacts with a panel of MAbs that are specific for mature monocytes, i.e., M42, LeuM3, 63D3, Mo2 and UCHMI. By contrast, the monoblastic cell lines U937 and THP-I are negative for all these markers. Only expression of My4 could be detected after differentiation induced by interferon-gamma (IFN-gamma). Similar treatment of Mono Mac I, however, resulted in staining with all the monocyte-specific MAbs mentioned above, while IFN-gamma treatment of Mono Mac 6 enhanced antigen expression. In addition, the cells showed an increased frequency of multinucleated cells with a rise from 4.8% to 21.9%. Mono Mac 6 appears to be the only one of the cell lines studied to constitutively express phenotypic and functional features of mature monocytes.
EFO_0006294	SHEP	SH-EP is derived from SK-N-SH cell line. Cells of SH-EP are flattened in shape and do not have neuritic processes.
EFO_0006296	STS26T	STS26T cells were derived from a sporadic MPNST and have functional neurofibromin
EFO_0006304	T265	The T265 cell line is widely used for cell culture studies of Schwann cells in MPNSTs. This cell line has characteristics consistent with Schwann cells that have been transformed into a malignant phenotype because of the loss of neurofibromin in the auto-somal-dominant condition NF1
EFO_0006354	105KC	Human chondrosarcoma cell line.
EFO_0006355	143B	Human osteosarcoma cell line. ATCC catalog number CRL-8308
EFO_0006358	59M	Human ovarian carcinoma cell line. (Sigma-Aldrich catalog number 89081802)
EFO_0006362	A2780	Human ovarian carcinoma cell line. (Sigma-Aldrich catalog number 93112519)
EFO_0006364	C32	Human melanoma cell line. ATCC catalog number CRL-1585
EFO_0006365	C4-2B	Human prostate cancer cell line derived from subcutaneous LNCaP xenografts in castrated nude mice.
EFO_0006366	CAL 27	Human squamous cell carcinoma cell line
EFO_0006373	COLO 680N	Human squamous cell carcinoma cell line (DSMZ catalog number ACC 182)
EFO_0006376	COLO 783	Human melanoma cell line (DSMZ catalog number ACC257)
EFO_0006377	COLO 792	Derived from a brain metastasis of a 62 year old male with melanoma. The cells bleb during culture. (Sigma-Aldrich catalog number 93052616)
EFO_0006378	COLO 800	Derived from a subcutaneous nodule of a tumour from a 14-year-old male. Cells display remarkable blebbing. (Sigma-Aldrich catalog number 93051123)
EFO_0006379	COLO 849	derived in 1992 from right axillary lymph nodes of a 43-year-old Caucasian man with metastatic maligant melanoma (DSMZ catalog number ACC 216)
EFO_0006380	COLO 853	Derived from the right axilla lymph node of a 43 year old male with melanoma. (Sigma-Aldrich catalog number 93052606)
EFO_0006381	COLO 857	Derived from a right axilla lymph node of a 43 year old male with melanoma. The biopsy material was obtained post chemotherapy. (Sigma-Aldrich catalog number 93051120)
EFO_0006382	COV318	A human ovarian epithelial-serous carcinoma cell line established from a peritoneal ascites. Anchorage-independent growth in agar has been reported. (Sigma-Aldrich catalog number 07071903)
EFO_0006383	COV362	A human ovarian epithelial-endometroid carcinoma cell line established from a pleural effusion. Anchorage-independent growth in agar has been reported. (Sigma-Aldrich catalog number 07071910)
EFO_0006384	COV434	Human ovarian granulosa tumour cell line established from a solid primary tumour (Sigma-Aldrich catalog number 07071909)

EFO_0002831

MKN28

Well differentiated human gastric adenocarcinoma cell line.

EFO_0002832

MKN45

Human gastric adenocarcinoma, established from the poorly differentiated adenocarcinoma of the stomach (medullary type) of a 62-year-old woman.

EFO_0002839

MSTO-211H

Human mesothelioma cell line; established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic) who did not have any prior therapy.

EFO_0002853

RM 82

A cell line derived from human 39 s sarcoma.

EFO_0002854

SBC-3

A cell line derived from human small cell lung carcinoma.

EFO_0002895

MKN7

Well differentiated human gastric adenocarcinoma cell line.

EFO_0002957

2102Ep

2102ep is an embryonal cell line

EFO_0002959

NTera2

A human embryonal carcinoma (EC) stem cell line used as a model system for the study of neuronal differentiation

EFO_0002960

BG03

A human embryonic stem cell line

EFO_0002961

NTera2 derived dopaminergic neuronal like cells

A human embryonal carcinoma (EC) stem cell line used as a model system for the study of neuronal differentiation and differentiated into neuronal like cells

EFO_0003039

EAhy 926 cell

The EAhy 926 cell is a hybridoma line derived from human endothelium and A549/8 cells. They display stable endothelial characteristics and may provide an indication of how endothelial cells respond to photodynamic therapy.

EFO_0003042

H1-hESC

H1 human embryonic stem cell line, usually called H1-hESC and on occasion just H1

EFO_0003045

H9

This human ES cell line expresses cell surface markers specific to undifferentiated nonhuman primate ES and human EC cells: stage-specific embryonic antigen (SSEA)–3, SSEA-4, TRA-l-60, TRA-1- 81, and alkaline phosphatase. It has a normal 46, XX karyotype. Teratomas are formed upon cell injection into SCID mice. These teratomas include cells from all three germ layers. Isolation & Growth Conditions This cell line can be cultured using feeder cells or in a feeder-free protocol. When using feeder cells, human ESC culture medium should be compreised of Advanced DMEM/F12 supplemented with knockout serum replacement (20%), non-essential amino acids (1x), L-glutamine (1x), penicillin/streptomycin (1x), β-mercaptoethanol (1x) and FGF-2 (4 ng/ml). Maintain the human ESCs on Matrigel using hESC medium conditioned by mouse embryonic fibroblasts.

EFO_0003056

M14

The human melanoma cell line M14 has been established from surgically removed melanoma metastases.

EFO_0004389

UCH-1

Human chordoma cell line.

EFO_0004921

GM00038

Apparently health human non-fetal tissue.

EFO_0004922

GM00719

ATAXIA-TELANGIECTASIA; AT

EFO_0005231

ECC-1

An established epithelial cell line derived from an adenocarcinoma of human endometrial lining.

EFO_0005234

PFSK-1

Neuroectodermal cell line derived from a cerebral brain tumor.

EFO_0005236

NT2/D1

The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line. Derived from metastatic site: lung

EFO_0005237

U-87 MG

A human epithelial cell derived from subject with grade IV glioblastoma; astrocytoma.

EFO_0005263

TOV-112D

TOV-112D is a human epithelial cell line initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.

EFO_0005264

Ect1

The ectocervical Ect1/E6E7 (ATCC CRL-2614) and endocervical End1/E6E7 (ATCC CRL-2615) cell lines were established in 1996 from normal epithelial tissue taken from a premenopausal woman undergoing hysterectomy for endometriosis.

EFO_0005265

MOLT-3

MOLT-3 is a male human malignant T-lymphoblastic cell line.

EFO_0005282

HS-5

Established from human bone marrow stromal cells transformed by HPV-16 E6/E7.

EFO_0005283

HS-27A

Established from human bone marrow stromal cells transformed by HPV-16 E6/E7.

EFO_0005355

HUES1

A human embryonic stem cell line

EFO_0005384

HuH-7

HuH-7 is a well differentiated hepatocyte derived cellular carcinoma cell line that was originally taken from a liver tumor in a 57-year-old Japanese male in 1982. The line was established by Nakabayshi, H. and Sato, J. HuH-7 is an immortal cell line of epithelial-like tumorigenic cells. It usually grow in 2D monolayers.

EFO_0005388

JIMT-1

Source : Pleural effusion, Ductal breast cancer (grade 3 invasive, T2N1M0) Karyotype : Highly rearranged hyperdiploid karyotype with 6% polyploidy Carry an amplified HER-2 oncogene and to be insensitive to HER-2-inhibiting drugs

EFO_0005441

DU 145

A cell line derived from human prostate carcinoma. The patient was a 69-year-old male, and the sample was derived from brain metastasis.

EFO_0005445

PEO1

PEO1 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO1 is tumourigenic in immunologically-deprived CBA mice. PEO1 exhibits good growth in semi-solid medium (agar). PEO1 is from the same patient as the PEO4 and PEO6 cell lines (Sigma Catalogue numbers 10032309 & 10032310).This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) available at ECACC which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. (Sigma-Aldrich catalog number 10032308)

EFO_0005696

D721Med

Medulloblastoma (aka D721), surgical resection from a patient with medulloblastoma as described by Darrell Bigner (1997)

EFO_0005697

M059J

M059J cells were isolated from a tumor specimen taken from a 33 year old male with untreated malignant glioblastoma. The cells were isolated concurrently from the same tumor specimen as M059K (see CRL-2365).

EFO_0005698

Daoy

The Daoy cell line was established in 1985 by P. F Jacobsen of the Royal Perth Hospital in Western Australia. The line was derived from biopsy material taken from a tumor in the posterior fossa of a 4 year old boy.

EFO_0005700

TTC549

This is an adherent cell line derived from a hepatic rhabdoid tumor. Hepatic rhabdoid tumors are extremely rare. This cell line has a large deletion on 22q, which indicates numerous genes in addition to SNF5 are deleted.

EFO_0005702

A204.1

A malignant rhabdoid tumor diploid cell population cloned from the A204 ATCC cell line. [PMID: 16897758]

EFO_0005703

G401.6

This is an adherent cell line that represents the prototypical renal rhabdoid tumor [PMID: 16897758]. G401.6 is a diploid, 6-thioguanine-resistant clonal variant of the G401 cell line isolated by Weissman et al., Science, 236:175-180 (1986). The parental cell line, G401, can be ordered from the ATCC (CRL1441).

EFO_0005704

HuH-7.5

HuH-7 is a well differentiated hepatocyte derived cellular carcinoma cell line that was originally taken from a liver tumor in a 57-year-old Japanese male in 1982. The line was established by Nakabayshi, H. and Sato, J. HuH-7 is an immortal cell line of epithelial-like tumorigenic cells. It usually grow in 2D monolayers. HuH7.5 developed from HuH7.

EFO_0005705

olfactory neurosphere cell line

Nasal biopsies were collected from volunteer donors as an outpatient procedure as described (Feron et al., 1998). This was done by a registered otolaryngologist via an endoscopic procedure to ensure biopsy samples were taken from the superior, posterior region of the nasal septum close to the cribriform plate. Pieces of olfactory mucosa were obtained which contain stem cells in the olfactory epithelium. The stem cell population derived from human olfactory mucosa has been described as ecto-mesenchymal (Delorme et al., 2010) because it has characteristics of both neural and mesenchymal stem cells, suggesting a neural crest origin.

EFO_0009494

C1 100080002

Cell line from olfactory neurosphere cells from a 59-year-old human male.

EFO_0009495

C1 100080003

Cell line from olfactory neurosphere cells from a 66-year-old human female.

EFO_0009496

C1 100080013

Cell line from olfactory neurosphere cells from a 64-year-old human male.

EFO_0005706

Mel-2183

in the Surgery Branch of the NCI.">This cell line was from a melanoma metastasis tumor taken from the subcutaneous shoulder of an individual. Cell line was derived by Dr. Yardena Samuels (samuelsy[at]mail.nih.gov)

EFO_0005707

786-0

This line was derived from a primary clear cell adenocarcinoma. The karyotype is hypertriploid; Y was present in 60% the cells examined. The cells display both microvilli and desmosomes, and can be grown in soft agar. The cells produce a PTH like peptides that is identical to peptides produced by breast and lung tumors.

EFO_0005709

HTR8/SVneo

First trimester human trophoblast cells established by immortalizing a physiologic extravillous trophoblast cell via transfection with a plasmid containing the simian virus 40 large T antigen (SV40) (see Graham et al., 1993). Cells are a thin layer of ectoderm that forms the wall of many mammalian blastulas and functions in the nutrition and implantation of the embryo.

EFO_0005710

HFF-Myc

This is an adherent cell line. HFF-Myc are human foreskin fibroblasts containing a virally integrated vector expressing the canine cMyc gene. Cells were received from Dr. Beverly Torok-Storb, Fred Hutchison Cancer Research Center, Seattle, WA.

EFO_0005711

HPDE6-E6E7

Normal benign adult human pancreatic duct cells immortalized with E6E7 gene of HPV-16. HPDE6-E6E7 cells demonstrated a near normal genotype and phenotype of pancreatic duct epithelial cells. [PMC1861644]

EFO_0005712

RPMI-7951

Human skin malignant melanoma cells that can be ordered from ATCC. This is a hyperdiploid human cell line with the modal chromosome number of 49, occurring in 24% of cells. Polyploid cells occurred at 22%, which is high. Cells are adherent, and were first harvested in 1971 from a metastatic site in a lymph node.

EFO_0005713

8988T

Human pancreas adenocarcinoma (PA-TU-8988T), "established in 1985 from the liver metastasis of a primary pancreatic adenocarcinoma from a 64-year-old woman; sister cell line of PA-TU-8988S" - DSMZ.

EFO_0005714

LHCN-M2

Skeletal myoblasts derived from satellite cells from the pectoralis major muscle of a 41 year old caucasian heart transplant donor, immortalized with lox-hygro-hTERT (LH), and Cdk4-neo (CN), Zhu et al. (2007) in Aging Cell, vol. 6, pp 515-523. M2 is an extremely well-differentiating subclone of LHCN (thus "LHCN-M2").

EFO_0005715

WERI-Rb-1

The WERI-Rb-1 line is one of two human retinoblastoma cell lines established in 1974 by R.M. McFall and T.W. Sery. This is a near diploid line. The modal chromosome number is 47 occurring at 38%, and the rate of polyploidy is 9%. Cells are grape-like clusters of round cells in suspension.

EFO_0005718

Ishikawa

"The cell line Ishikawa was established from an endometrial adenocarcinoma of a 39 year old woman. Cells can be commercially obtained from Sigma (99040201-1VL). However, it should be noted that the original source of these cells (M. Nashide, Japan) can spontaneously lose the progesterone and estrogen receptor. For details, see Nishida M., The Ishikawa cells from birth to the present. Hum Cell. 2002 Sep;15(3):104-17."

EFO_0005720

SK-MEL-5

This melanoma cell line was derived from a metastatic axillary node of the skin of a 24 year old female. It is a hyperpentaploid human cell line with the modal chromosome number of 120, occurring in 9% of cells. [PMID: 1067619]

EFO_0005721

SK-N-DZ

SK-N-DZ is a neuroblastoma cell line derived in 1978 from a bone marrow metastasis from a child with poorly differentiated embryonal neuroblastoma.

EFO_0005722

SJRH30

The line was established from cells from the bone marrow of a child with rhabdomyosarcoma. Derived from a metastatic site of the bone marrow. The cells show ultrastructural elements of primitive skeletal muscle differentiation.

EFO_0005723

GM23248

Fibroblasts taken from a skin punch of the arm

EFO_0005724

MM.1S

MM.1S is a B lymphoblast cell line derived in 1986. The parent cell line, MM.1, was established from peripheral blood of a multiple myeloma patient who had become resistant to steroid-based therapy. provide critical information about disease progression and the development of drug resistance. This cell line represents a valuable tool for elucidating the mechanisms of action of glucocorticoids and the development of new therapeutics. [PMID: 2926241]

EFO_0005725

BE(2)-C

BE(2)-C is a clone of the SK-N-BE(2) neuroblastoma cell line (ATCC CRL-2271) that was established in November of 1972 from a bone marrow biopsy taken from child with disseminated neuroblastoma after repeated courses of chemotherapy and radiotherapy. The cells grow as clusters of flattened neuroblastic cells with occasional fine cell processes (neurites). Unlike the parent line, they generally do not detach and float.

EFO_0005726

LNCaP clone FGC

LNCaP clone FGC was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old Caucasian male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma. This is a hypotetraploid human cell line. The modal chromosome number was 84, occurring in 22% of cells. However, cells with chromosome counts of 86 (20%) and 87 (18%) also occurred at high frequencies. These cells are responsive to 5-alpha-dihydrotestosterone (growth modulation and acid phosphatase production).

EFO_0005901

ELF-1

Human embryonic stem cell line ELF-1 was derived from a human embryo in the Ellison Stem Cell Core at the University of Washington, Seattle, WA.

EFO_0005903

KBM-7

KBM-7 cells were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. The original cell line contained both near haploid and hyperdiploid clones. Subsequent subcloning yielded a pure near-haploid cell line.Genome analysis has revealed that besides the disomic chromosome 8 also a 30 megabase fragment of chromosome 15 is present in two copies. Like other CML cells lines (e.g., K562) KBM-7 cells are positive for the Philadelphia chromosome harboring the BCR-ABL oncogenic fusion. KBM-7 cells have been reprogrammed to yield the HAP1 cell line which is also haploid for chromosome 8.

EFO_0007598

HAP-1

HAP1 is a near-haploid human cell line that was derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. HAP1 cells are adherent with fibroblast-like morphology.

EFO_0005904

H7-hESC

Undifferentiated embryonic stem cells

EFO_0005907

OCI-LY1

Established from the bone marrow of a 44-year-old man with B-cell Non-Hodgkin lymphoma (B-NHL; diffuse large cell), stage 4B at relapse in 1983.

EFO_0005909

HGADFN167

Dermal fibroblasts from an 8 year old male with Hutchinson-Gilford progeria syndrome (cell line HGPS, HGADFN167, progeria research foundation).

EFO_0005912

hTERT-HM

An immortalized cell line from hTERT-infected myometrial cells (hTERT-HM). Cells were isolated from myometrial tissue obtained from women undergoing hysterectomy, and retroviral infection was used to express the catalytic subunit of telomerase in myometrial cells.

EFO_0005913

urothelium cell line

Primary ureter cell culture of urothelial cells derived from a 12 year-old girl and immortalized by transfection with a temperature-sensitive SV-40 large T antigen gene.

EFO_0006268

A431

The epidermoid carcinoma cell line A-431, derived from an 85-year-old female, is one of a series of cell lines established from solid tumors by D.J. Giard, et al. This is a hypertriploid human cell line. The modal chromosome number was 74 occurring in 36% of cells. The rate of cells with higher ploidies was 1.0%.

EFO_0006269

ACH-3P

Cell line was established by fusion of primary human first trimester trophoblasts (week 12 of gestation) with a human choriocarcinoma cell line (AC1-1).

EFO_0006270

AG04450

The culture was initiated on 5/20/80 from explants of minced lung tissue taken from a therapeutically aborted fetus of 12 weeks gestational age. The cell morphology is fibroblast-like. The karyotype is 46,XY; normal diploid male. A matched skin-derived fibroblast culture from same fetus is AG04449.

EFO_0006271

ARPE-19

ARPE-19 is a spontaneously arising retinal pigment epithelia (RPE) cell line derived in 1986 by Amy Aotaki-Keen from the normal eyes of a 19-year-old male who died from head trauma in a motor vehicle accident.

EFO_0006276

GM15850

Clinically affected; ataxia; scoliosis; hypertrophic cardiomyopathy; slurred speech; homozygous for the GAA expansion in the frataxin gene with alleles of approximately 650 and 1030 repeats; brother of GM15849 and GM15851, son of GM15847 and GM15848.

EFO_0006277

GM15851

Clinically unaffected;has two FRDA alleles in the normal range of GAA trinucleotide repeats;brother of an affected individual (GM15850).

EFO_0006278

GM5659

GM5659 primary fibroblasts were established from a skin biopsy of an apparently healthy donor

EFO_0006279

HPAF1

Cell line is derived from the normal human parotid gland. The cell lines are propagated in serum-free medium comprised of keratinocyte basal medium supplemented with insulin (5 micrograms/ml), hydrocortisone (0.5 micrograms/ml),epidermal growth factor (EGF, 10 ng/ml), bovine pituitary extract (25 micrograms/ml), and antibiotics. Normal diploid karyotypes, lack transformed phenotypes and non-tumorigenic in nude mice. Produces tissue-specific proteins, i.e. α-amylase 1, basic proline-rich protein, and cystatins; and expressed the corresponding genes as determined by RT-PCR analyses.

EFO_0006280

HPAM1

Cell line is derived from the normal human parotid gland. The cell lines are propagated in serum-free medium comprised of keratinocyte basal medium supplemented with insulin (5 micrograms/ml), hydrocortisone (0.5 micrograms/ml),epidermal growth factor (EGF, 10 ng/ml), bovine pituitary extract (25 micrograms/ml), and antibiotics. Normal diploid karyotypes, lack transformed phenotypes and non-tumorigenic in nude mice. Produces tissue-specific proteins, i.e. α-amylase 1, basic proline-rich protein, and cystatins; and expressed the corresponding genes as determined by RT-PCR analyses.

EFO_0006281

JinB8

CD47-deficient T cell line derived from Jurkat cells (JinB8)

EFO_0006282

KM12

KM12 is one of the cell lines of the NCI-60 panel which represents different cancer types and has been widely utilized for drug screening and molecular target identification.

EFO_0006285

MEC2

Cell line grew spontaneously on two subsequent occasions from the peripheral blood (PB) of a patient with B-chronic lymphocytic leukemia (B-CLL) in prolymphocytoid transformation. The patient was EBV-seropositive, his leukemic cells were EBNA negative, but the spontaneously grown cell lines are EBNA-2 positive. MEC2 cells do not adhere and form large clumps. The doubling time of MEC2 is 31h.

EFO_0006287

Mono Mac 6

A monocytic cell line, termed Mono Mac, was established from peripheral blood of a patient with monoblastic leukemia. Two clones, designated Mono Mac I and Mono Mac 6, were isolated and both were assigned to the monocyte lineage on the basis of morphological, cytochemical and immunological criteria. Most importantly, the clones express NaF-sensitive non-specific-esterase, produce reactive oxygen and stain with MAb My4. Mono Mac 6, in addition, constitutively exhibits phagocytosis of antibody-coated erythrocytes in 80% of the cells and reacts with a panel of MAbs that are specific for mature monocytes, i.e., M42, LeuM3, 63D3, Mo2 and UCHMI. By contrast, the monoblastic cell lines U937 and THP-I are negative for all these markers. Only expression of My4 could be detected after differentiation induced by interferon-gamma (IFN-gamma). Similar treatment of Mono Mac I, however, resulted in staining with all the monocyte-specific MAbs mentioned above, while IFN-gamma treatment of Mono Mac 6 enhanced antigen expression. In addition, the cells showed an increased frequency of multinucleated cells with a rise from 4.8% to 21.9%. Mono Mac 6 appears to be the only one of the cell lines studied to constitutively express phenotypic and functional features of mature monocytes.

EFO_0006294

SHEP

SH-EP is derived from SK-N-SH cell line. Cells of SH-EP are flattened in shape and do not have neuritic processes.

EFO_0006296

STS26T

STS26T cells were derived from a sporadic MPNST and have functional neurofibromin

EFO_0006304

T265

The T265 cell line is widely used for cell culture studies of Schwann cells in MPNSTs. This cell line has characteristics consistent with Schwann cells that have been transformed into a malignant phenotype because of the loss of neurofibromin in the auto-somal-dominant condition NF1

EFO_0006354

105KC

Human chondrosarcoma cell line.

EFO_0006355

143B

Human osteosarcoma cell line. ATCC catalog number CRL-8308

EFO_0006358

59M

Human ovarian carcinoma cell line. (Sigma-Aldrich catalog number 89081802)

EFO_0006362

A2780

Human ovarian carcinoma cell line. (Sigma-Aldrich catalog number 93112519)

EFO_0006364

C32

Human melanoma cell line. ATCC catalog number CRL-1585

EFO_0006365

C4-2B

Human prostate cancer cell line derived from subcutaneous LNCaP xenografts in castrated nude mice.

EFO_0006366

CAL 27

Human squamous cell carcinoma cell line

EFO_0006373

COLO 680N

Human squamous cell carcinoma cell line (DSMZ catalog number ACC 182)

EFO_0006376

COLO 783

Human melanoma cell line (DSMZ catalog number ACC257)

EFO_0006377

COLO 792

Derived from a brain metastasis of a 62 year old male with melanoma. The cells bleb during culture. (Sigma-Aldrich catalog number 93052616)

EFO_0006378

COLO 800

Derived from a subcutaneous nodule of a tumour from a 14-year-old male. Cells display remarkable blebbing. (Sigma-Aldrich catalog number 93051123)

EFO_0006379

COLO 849

derived in 1992 from right axillary lymph nodes of a 43-year-old Caucasian man with metastatic maligant melanoma (DSMZ catalog number ACC 216)

EFO_0006380

COLO 853

Derived from the right axilla lymph node of a 43 year old male with melanoma. (Sigma-Aldrich catalog number 93052606)

EFO_0006381

COLO 857

Derived from a right axilla lymph node of a 43 year old male with melanoma. The biopsy material was obtained post chemotherapy. (Sigma-Aldrich catalog number 93051120)

EFO_0006382

COV318

A human ovarian epithelial-serous carcinoma cell line established from a peritoneal ascites. Anchorage-independent growth in agar has been reported. (Sigma-Aldrich catalog number 07071903)

EFO_0006383

COV362

A human ovarian epithelial-endometroid carcinoma cell line established from a pleural effusion. Anchorage-independent growth in agar has been reported. (Sigma-Aldrich catalog number 07071910)

EFO_0006384

COV434

Human ovarian granulosa tumour cell line established from a solid primary tumour (Sigma-Aldrich catalog number 07071909)