dotan1111 commited on
Commit
a26c339
1 Parent(s): b50a1a0

Upload README.md

Browse files
Files changed (1) hide show
  1. README.md +6 -0
README.md CHANGED
@@ -17,6 +17,12 @@ We used SpartaABC (Loewenthal et al., 2021) to generate millions of true alignme
17
 
18
  We generated 1,495,000, 2,000 and 3,000, protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range *(0.5,1.0)*. Next, the sequences were generated using SpartaABC with the following parameters: *R_I,R_D \in (0.0,0.05)*, *A_I, A_D \in (1.01,2.0)*. The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range *[32,44]*. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides *(0.37, 0.166, 0.307, 0.158)*, in the order "T", "C", "A" and "G"; (2) with the substitutions rate *(0.444, 0.0843, 0.116, 0.107, 0.00027)*, in the order "a", "b", "c", "d", and "e" for the substitution matrix.
19
 
 
 
 
 
 
 
20
  ## APA
21
 
22
  ```
 
17
 
18
  We generated 1,495,000, 2,000 and 3,000, protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range *(0.5,1.0)*. Next, the sequences were generated using SpartaABC with the following parameters: *R_I,R_D \in (0.0,0.05)*, *A_I, A_D \in (1.01,2.0)*. The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range *[32,44]*. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides *(0.37, 0.166, 0.307, 0.158)*, in the order "T", "C", "A" and "G"; (2) with the substitutions rate *(0.444, 0.0843, 0.116, 0.107, 0.00027)*, in the order "a", "b", "c", "d", and "e" for the substitution matrix.
19
 
20
+ ## Example:
21
+
22
+ The following example correspond for the illustrated MSA in the figure above:
23
+
24
+ {"MSA": "AAAC-GGG", "unaligned_seqs": {"seq0": "AAG", "seq1": "ACGG"}}
25
+
26
  ## APA
27
 
28
  ```