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taxon
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2.75k
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5.51k
AlphaFoldDB
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A6MMP3
RR8_DIOEL
30S ribosomal protein S8, chloroplastic
Dioscorea
MGRDTIANIITSIRNADMDKKGTVRIASTNITENIVKILLREGFIENVRKHQENQRFFLVSTLRHRRTSKGVYRTILKRISRPGLRIYSNYQRIPKILGGIGIVILSTSQGIMTDREARLKKIGGEILCYIW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A6MMP3
B9KAT4
TIG_THENN
PPIase
Thermotoga
MEVKELERDKNRVVLEYVFNREEVLEAEDKAARYLNQRVEIPGFRKGRVPKNILKMRLGEDFQEYTLDFLMDLIPDTLKDRNLIMSPVVTEREIKEDTARFVVEVHEEPEVKIGDVSKIEVEKVDEEKVLEKYVERRLEDLREKHALLEPKEGPAEVGDLVRISMEVYNEEGKNLTTREYEYVIKEGEDRPFVKDLIGKKKDDVVEIEREYEGKKYTYRLKVQEVYRRTLPEIGDELARTVNNEFETLEQLKEELKKEGKDIYDVEMKESMREQLLEKLPEVVEIEISERTLDLLVQETINRLKREGRYDQIVSSYESEEKLKEELKKRILDDIKRDRAIEVIAKERNVDVSDEELEKEAEELAPFWGISPERAKSLVKSRRDLREDLRWAILKRKVLDLLLEEVTVKVVEPRGEGDGDERKGDN
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
B9KAT4
Q0T203
RODZ_SHIF8
Cytoskeleton protein RodZ
Shigella
MNTEATHDQNEALTTGARLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPADLASTFLRGYIRSYARLVHIPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMTFTWLVLFVVIGLSGAWWWQDHKAQQEEITTMADQSSAELSSNSEQGQSVPLNTSTTTDPATTSTPPASVDTTATNTQTPAVTAPAPAVDPQQNAVVSPSQANVDTAATPVPTAATTPDGAAPLPTDQAGVTTPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEQSPAQ
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
Q0T203
Q98QU4
ATPG_MYCPU
F-ATPase gamma subunit
Mycoplasmopsis
MPSLQKTKNRIALIDNIKKITKAMELVATSKMKKTQKHFLEVNEFSQSVLDIFSKIVSQIDPQIKLYPDGQKNSTLYIVISSDIGLAGSYNSNIFKILNSNIKNEDKLILIGQKAINFFSNRQDQIIETFKALPDYVTYKIAKLISDSALNSFLNKDVNQIKVVYTKFINLINQQEKISTILPIKKNPMKSEIKENAILEFEPDVESVFHKAIPLYLASIIFGFLTESKVSELAARRTAMESASKNAIDLIGNLKIEYNQTRQAKITQEISEIVAGSVE
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Q98QU4
Q46LV5
KHSE_PROMT
Homoserine kinase
Prochlorococcus
MGPPKIGQTVVVEVPSTTANIGPGFDCLGAALDLSNQFTIKRIEGNAERFELIMESTEGNHLRGGPENLFYRAAQRVWRTAGIEPVALEARVKLAVPPARGLGSSATAIVAGLVGANALAGYPLPKEKLLELAIDIEGHPDNVVPSLIGGLCVTAKTASDRWRVVRCDWDKSIKAVVAIPSIRLSTSEARRVMPENIPVNDAVINLGALTLLLQGLRTGNEDLITDGMHDKLHEPYRWGLIKGGLEVREAAKAAGALGCAISGAGPSILALCKATKGREVSVAMVKAWEAAGVASRAPLMSLQLTGSECISNTFG
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Q46LV5
Q5X0C7
RPIA_LEGPL
Phosphoriboisomerase A
Legionella
MSELKIKAAKAAIAYIEDDMVIGVGTGSTVNFFIKELAAIKHKIEACVASSKATEALLRAEGIPVIDLNSVQDLPIYVDGADEVNERGEMIKGGGGALTREKIVANVATQFICIVDESKVVKRLGEFPVAVEVIPMARSFVARQIVKLGGDPEYREGFITDNGNIILDVFNLNFSTPMALEDSLNVIPGVVENGVFAKRLADKVLVASASGVNNLK
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q5X0C7
Q8U089
TRPD_PYRFU
Anthranilate phosphoribosyltransferase
Pyrococcus
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAIKLDLGEVLDTAGTGGDKSFTINVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGINIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKELGIKTIFNILGPLANPANPAYQVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTPEDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGVELAENVLGEKIIKKLEEIACLSKS
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8U089
P96195
LEUC_AZOVI
Isopropylmalate isomerase
Azotobacter
MAGKTLYDKLWDMHEVKRRDDGSSLIYIDRQILHEVTSPQVRGAAPGRANVARGCQHRHPGPQRADHPGSPVGGRRHRRRNLAHPGADPGRELRRVRHRRVQDERPAPGHRPCGRPGAGRHLPGMTVVCGDSHTSTHWCGALAHGIGTSEVEHVLATQCLVAKKMKNMQVRVEGELPLGVSAKDIVLAVIGRIGTAGGTGHALEFAGSAIRGLSMEGRMTLCNMAIEAGARVGMVAVDEKTIDYVKGRPYAPQGADWDKAVAQWRELVSDADAGFDTVVELKAEEIRPQVTWGTSPEMVLPVDERVPDPASESDPVKRDSIVRALKYMGLAANQPIGEIKVDRVFIGSCTNSRIEDLRAAAEVAKGARSPRASSRRWWCRAPGWSRSRRRRRGWTGSSSRPVSSGATGCSMCLAMNPDRLESGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVAGRFVDVRQLLQA
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
P96195
B1VEY1
RS4_CORU7
30S ribosomal protein S4
Corynebacterium
MARYTGPVTRKSRRLRVDLVGGDRSFERRPYPPGQAGRARIKESEYLIQLQEKQKARFTYGVMEKQFRRYYAEANAMPGKTGDNLVILLEARLDNVIYRAGLARTRRQARQLVSHGHFTVNGKKINVPSFRVSQYDIIDVRDRSRSMLWFDEAQDNLVDANVPAWLQVVPSTLRILVHQLPERAQIDIPLQEQLIVEYYSK
With S5 and S12 plays an important role in translational accuracy.
B1VEY1
Q9VXA8
DXO_DROME
NAD-capped RNA hydrolase CG9125
Sophophora
MAENAGFISVPWGQHKLGAMYNTPFPSISRPKCIGVCSINASREFVDDASCASYLAGQPWPPLPFDLNGGIEDVIRKPVENGKRDLEIMLTYIKQHQKELLRQSSSDARNLRLDSDFVTLRGILRQIMCLQYDNRSFRVKATLLNGNVYMCKEETPEQQLENANMSRAQRVMCSWGFKFEQYLTSAQAQGKPVTNVPVNEAEEFMGVYRTNLAGILMLYGAELDCVDSKEPVDFKDCRVLDSLKFVELKTSVFNMNPHQIRTFKSFKSANWWSQSFLVGITTLYVGLRDTKGMLQRIDEIDVATLARNKPWSASAMAWYLEQFLRNLKKLLVNINDPFAVVQVTFLNKHASYEVLRGPEHQILPNWYRDLLKTRS
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control.
Q9VXA8
Q9HAZ2
PRD16_HUMAN
Transcription factor MEL1
Homo
MRSKARARKLAKSDGDVVNNMYEPNRDLLASHSAEDEAEDSAMSPIPVGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGIFAPGLPLTPSPMMDKAKPSPSLNHASLGFNEYFPSRPHPGSLPFSTAPPTFPALTPGFPGIFPPSLYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTTGTDLDTTTGTGSDLDSDVDSDPDKDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFFPPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMPQQPPLHYAKPSPFFMDPIYSRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQIVDGSAQCPGLASEKQEDVEEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASLAVGFDHTRRCAEDHEGGLLALEPMPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEALKHTLCRQAKNQAYAMMLSLSEDTPLHTPSQGSLDAWLKVTGATSESGAFHPINHL
Binds DNA and functions as a transcriptional regulator . Functions as a repressor of TGF-beta signaling . May regulate granulocyte differentiation .
Q9HAZ2
A0A096P8D3
IDH_OSTTA
Isocitrate dehydrogenase (NAD(+)), mitochondrial
Ostreococcus
MTRVERGRVLARAIERAVAHRASARRWTTTTRTPAWMVTGWMGGRGVDRSTAMTRFERCGSTASSKITAAPMVYVRGEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVIEAGKRIKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVLFERHAVGGEYSAGYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEAAVVTYHNPYDNVHDLARFFFGRCLEAKVTPYVVTKKTVFKWQEPFWQIMRTVFDEEFKAQFVAAGVMKEGEELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQVHKSPGFITSNLVGVHEDGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNIDRDRTHAFTTKMRTVIHQLFREGKGTRDLCGPSGLTTEQFIDAVAERLDA
Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (Probable). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production (Probable).
A0A096P8D3
P29295
HRR25_YEAST
Casein kinase I homolog HRR25
Saccharomyces
MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQRDLLIEKGDLNANSNAASASNSTDNKSETFNKIKLLAMKKFPTHFHYYKNEDKHNPSPEEIKQQTILNNNAASSLPEELLNALDKGMENLRQQQPQQQVQSSQPQPQPQQLQQQPNGQRPNYYPEPLLQQQQRDSQEQQQQVPMATTRATQYPPQINSNNFNTNQASVPPQMRSNPQQPPQDKPAGQSIWL
Protein kinase which phosphorylates serine and threonine residues . Can use casein as a substrate . Phosphorylates elongator complex member ELP1/IKI3 on 'Ser-1198' and 'Ser-1202' which promotes the tRNA modification function of the complex . Associated with repair of damaged DNA and meiosis .
P29295
Q3Z6W5
COAE_DEHM1
Dephosphocoenzyme A kinase
Dehalococcoides
MKIVGITGGIGSGKTTVCRYLKELGVNIIDADEIGHRVLQNKGIRTRITDVFGNEVMNPDGSINRKILGELVFGYPERLEHLNKITHPLIEQAIASLLEEYRQKGIKAVAIEAPLLVEAGWLKLVNEVWLITAPKESIFKRLRNRMGLSREQVMARIQSQATDNERLKYASIVINNNCRFEDLKSCVQLLAKERLELA
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Q3Z6W5
P0CB10
O162_CONAJ
Omega-conotoxin-like Ai6.2
Cylinder
MKLTCVMIIAVLFLTAWTFATADDSGNGLENLFSKAHHEMKNPKASKLNKRCTQSGELCDVIDPDCCNNFCIIFFCI
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
P0CB10
O69753
PHZB1_PSEAE
Phenazine biosynthesis protein PhzB1
Pseudomonas
MPDTTNPIGFTDANELREKNRATVEKYMNTKGQDRLRRHELFVEDGCGGLWTTDTGSPIVIRGKDKLAEHAVWSLKCFPDWEWYNINIFGTDDPNHFWVECDGHGKILFPGYPEGYYENHFLHSFELEDGKIKRNREFMNVFQQLRALSIPVPQIKREGIPT
Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth.
O69753
D7BAR0
GGAP_MEISD
Glucosylglycerate phosphorylase
Meiothermus
MSSLTPELRQSILEHLGFLYGERAPAVLGRLEEICSGFPAQRREGGWSEKDALLITYGDQIHAEGEPPLQTLYDFLYERLRGVFSGVHLLPFYPSTSDDGFSVVDFQRVDPELGTWTDIRIIAQDFRLMADLVCNHVSASSPWFQGFLQDDPQYQGFFITVDPGTDLSTVFRPRALPLLTPFQTPSGEKLVWTTFSPDQTDLNYANPEVLLEVIEALLCYVRNGAGLIRLDAVGFIWKEIGTSCMHLEGAHRIVKLMRLVLDAVAPHVLLVSETNAPHRENISYFGNGHDEAQLVYQFPLPPLVMHTFRTGDASKLAGWAAGLTLPSERTTFFNFLASHDGIGVVPAGGILQPEEIAALVRQALEHGGRVNHKDTPDGPVPYELCLTLFDALSNPNSDEAEDLKIARFLAANVILLSLQGIPGVYIHSLFGSPSDHAGFEESGIPRRLNRHKFTKAELEERLADPASRAAKILAAYSHLLRVRSMHPAFHPNAPQRILPSTEVLRIVRGEGDQAVGCYINVTDRPQVVSRIGKNLITGQWFTGVLKPYQAAWIID
Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D-glycerate. May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Has a very strict substrate specificity. Cannot catalyze the phosphorolysis of sucrose or synthesize sucrose from Glc1P and D-fructose.
D7BAR0
B2UFK5
ERPA_RALPJ
Putative iron-sulfur cluster insertion protein ErpA
Ralstonia
MNAVAQAATPDVNEVPAPLVFTDSAADKVKQLIEEEGNPELKLRVFVQGGGCSGFQYGFTFDEETNEDDTTMTKNGVSLLIDSMSYQYLVGAEIDYKEDINGAQFVIKNPNASTTCGCGSSFSV
Required for insertion of 4Fe-4S clusters.
B2UFK5
P82951
HEPC_MORCS
Hepcidin
Morone
MKTFSVAVAVAVVLAFICLQESSAVPVTEVQELEEPMSNEYQEMPVESWKMPYNNRHKRHSSPGGCRFCCNCCPNMSGCGVCCRF
Antimicrobial activity against Gram-negative bacteria such as E.coli.
P82951
M1V4Y8
CFA73_CHLRE
Modifier of inner arms 2 protein
Chlamydomonas
MDEEGSATARAKMMPQTLVLDHVSPATRLLEKRRQMFEVQEALEAQKQDFNRKEEVFKRREEALKLKDLELQESLIRFSKFLQENDSKRARAEKKANDEIKARIQKEKEIEQLTEVLEELKSEKERILEVLEKNMRYQHYLESVLEVADEYQEVADLLLRHATLSATNADLKDHQRKCSELAEKVRTELQIYVKQKTDEILNLNNQVAKLKTELEGYEAEAMVQEAKKDSSLQIASQRTLEYGQVVLSADNIFNRCRSKSSIGHPAESNPLHQLDVIGNFVSDLGSIIKQFKQEQAKRASLASRAEIE
As part of MIA, a complex associated with the outer doublet microtubules of the axoneme, may play a role in ciliary/flagellar motility by regulating the assembly and the activity of inner dynein arm.
M1V4Y8
C5D764
ARGC_GEOSW
N-acetyl-glutamate semialdehyde dehydrogenase
unclassified Geobacillus
MNIAIIGATGYGGVELLRFLQHHPHVHHCSLYSSSQDGIHFSESFPHVGEIEGAILQKIDVEQMADECEVVFFATPPGVSSTLAPTLIDKGVKVIDLSGDFRLKDRSVYEMWYKRQTASDHYLQQAVYGLTEWNKEDIQKAQLLSNPGCYPTAALLGLAPLVKERLIEEDSIIVDAKSGVSGAGRKASLNTHFSEVNENVKIYKVNSHQHIPEIEQMLKAWNERIQPITFSTHLIPMTRGIMATIYAKAKKELSLETLLDLYKTSYEDSKFVRVRKPGQFPATKEVYGSNYCDIGVAYDERTGRVTVVSVIDNLVKGAAGQAIQNLNVMMGWDEESGLMLAPIYP
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
C5D764
C3L3F3
ERA_CLOB6
GTPase Era
Clostridium
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASDAMKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLLKELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPIIIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
C3L3F3
Q07276
KLK1_MACFA
Tissue kallikrein
Macaca
MWFLVLCLALSLGGTGRAPPIQSRIVGGWECSQPWQAALYHFSTFQCGGILVHPQWVLTAAHCISDNYQLWLGRHNLFDDEDTAQFVHVSESFPHPGFNMSLLKNHTRQADDYSHDLMLLRLTQPAEITDAVQVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLEILPNDECAKAHTQKVTEFMLCAGHLEGGKDTCVGDSGGPLTCDGVLQGVTSWGYIPCGSPNKPAVFVKVLSYVKWIEDTIAENS
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Q07276
B2VIT0
AROL_ERWT9
Shikimate kinase 2
Erwinia
MSLPIYLIGARGCGKTTVGQALALALGYDFCDTDHYLQQARQQTVADIVAIEGWAGFRAREAESLKAVTAASKVIATGGGMVLAEENRLYMREHGRVIYLNANALVLAARLEAYPLADQRPTLTGRPVAEEMVEVLAARDALYQLAAHHIIDAMQTPDAVVNQIVSSLSLARAS
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
B2VIT0
O25488
ACPS_HELPY
4'-phosphopantetheinyl transferase AcpS
Helicobacter
MIGIDIVSIARIEKCVKRFKMKFLERFLSPSEIVLCKDKSSSIAGFFALKEACSKALQVGIGKELSFLDIKISKSPKNAPLITLSKEKMDYFNIQSLSASISHDAGFAIAVVVVSSSNE
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
O25488
B3EHV0
RISB_CHLL2
6,7-dimethyl-8-ribityllumazine synthase
Chlorobium
MQIKQIEGSLSAKDIRFALVVSRFNDFIGQKLVEGAIDCILRHGGSEEQITVYRCPGAFELPMVAKKVAMSGSADAVIALGVIIRGSTPHFDVIAAEATKGIAQVSLDTMIPVSFGVLTTENLEQAIERAGTKAGNKGFDAAMTAMEMVNLYRQF
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
B3EHV0
A7ZPW0
RLMN_ECO24
tRNA m2A37 methyltransferase
Escherichia
MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
A7ZPW0
B0G143
UCPB_DICDI
Uncoupler protein B
Dictyostelium
MTSQESIGIKFLFGGLSCMGAAVVSNPVDVLKTRFQIHGEGIDSKSLGLVNGTIKIIKNEGISAMYKGLTPSLLREATYSTLRMGGYDVIKNYFIDSNGKTNLLSKVTSGALSGALGACITSPTDLIKVRMQASSKGVKYDSISSAFKEIIAKEGIKGLWKGVGPTTQRAALLTASQIPSYDHIKHMILDHGIIQVDGLQVHIVSSIFAGLIASITTSPVDLVKTRIMNQPFDSNGVGLIYKSSYDCFKKTFQSEGISGLYKGFLPNWFRIGPHTIVTFILYEYLRKVSGIKPI
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
B0G143
Q97R61
FPG_STRPN
DNA-(apurinic or apyrimidinic site) lyase MutM
Streptococcus
MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDVYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Q97R61
P58427
TXHP3_HETVE
Toxin AU5C/KJ7
Heteropoda
ECGTLFSGCSTHADCCEGFICKLWCRYERTW
Blocks transient outward voltage-gated potassium channels in rat ventricular myocytes (thus prolonging action-potential duration) and rat Kv4.2/KCNA4 channels expressed in Xenopus oocytes. Is also a weak blocker of calcium channels in rat cerebellar granule cells.
P58427
Q1GPB8
RL15_SPHAL
50S ribosomal protein L15
Sphingopyxis
MTIKLNELRDNNGARKGRMRVGRGIGSGKGKTAGRGQKGQKARSGVAINGFEGGQMPLHMRIPKRGFNNIFGKDFAIVNLGMVQKLIDAKKLDAKATIDHAALKAAGVARGGKDGVRLLAKGELTAKVTFAVAGASKGAIEAVEKAGGKVELPEARPEGDGKKATRKAEAAAKNA
Binds to the 23S rRNA.
Q1GPB8
O08603
RAE1B_MOUSE
Retinoic acid early-inducible protein 1-beta
Mus
MAKAAVTKRHHFMIQKLLILLSYGYTNGLDDAHSLRCNLTIKDPTPADPLWYEAKCFVGEILILHLSNINKTMTSGDPGETANATEVKKCLTQPLKNLCQKLRNKVSNTKVDTHKTNGYPHLQVTMIYPQSQGRTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGEFVKQLKFLIHECSQKMDEFLKQSKEKPRSTSRSPSITQLTSTSPLPPPSHSTSKKGFISVGLIFISLLFAFAFAM
Acts as a ligand for KLRK1.
O08603
Q3A668
RIBB_SYNC1
3,4-dihydroxy-2-butanone 4-phosphate synthase
Syntrophotalea
MSQSLLDRFGTPLERVHLAIDRLRQGRGVLLVDDENRENEGDLIFPAETITPAQMAMMIRECSGIVCLCLTEDKLKQLELPQMVSDNTSANQTAFTLSIEARQGVTTGVSAADRVTTIRTAVADDCRPDDLARPGHVFPLRARPGGVLTRRGHTEGTVDLMRMAGYKPAGVLCELTNEDGTMARLPEIITFAERHYLSVVSIEDLALALESHMEKSA
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Q3A668
Q5P4R1
METXS_AROAE
Homoserine transsuccinylase
Aromatoleum
MIQPQSVGAVVPQRAHFAEPLPLRSGDALPEYELLYETYGELNAARSNAVLVCHALSGSHHVAGHYADDPGNIGWWDNLVGPGKPLDTRKFFVIGVNNLGGCHGTTGPASINPASGKPWGADFPFVTVEDWVAAQARLADRLGIERFAAVVGGSLGGMQALSWTLQYPERIGHAVLVASAPRLTAQNIAFNEVARQAILSDPDFHGGHYYEHGVVPARGLKLARMLGHITYLSDDAMADKFGRTLRHGKAVYSYDVEFEIESYLRYQGDKFAGFFDANTYLLTTKALDYFDPAFEHGGILRAALARASADFLVVSFSTDWRFSPARSREIVYSLLHNRRNVSYAEIESDAGHDSFLLDDAHYHELLAAYFDRIEV
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Q5P4R1
A1A4L0
SNX4_BOVIN
Sorting nexin-4
Bos
MEQAAPDPERLWQPAPLEPLSHPDAGLESMVGEETKGARDEGPGDGTMTENNFSLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHNDGQSVLTDSLWRRYSEFELLRNYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRVASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFIELKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELATGTVRTFSLKGMTTKLFGQETPEQREARIKMLEEQIKEGEQQLKSKNLEGREFVRNAWADIERFKEQKNHDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.
A1A4L0
O29285
AMT1_ARCFU
Af-Amt1
Archaeoglobus
MSDGNVAWILASTALVMLMVPGVGFFYAGMVRRKNAVNMIALSFISLIITVLLWIFYGYSVSFGNDISGIIGGLNYALLSGVKGEDLLFMMYQMMFAAVTIAILTSAIAERAKVSSFILLSALWLTFVYAPFAHWLWGGGWLAKLGALDFAGGMVVHISSGFAALAVAMTIGKRAGFEEYSIEPHSIPLTLIGAALLWFGWFGFNGGSALAANDVAINAVVVTNTSAAVAGFVWMVIGWIKGKPGSLGIVSGAIAGLAAITPAAGFVDVKGAIVIGLVAGIVCYLAMDFRIKKKIDESLDAWAIHGIGGLWGSVAVGILANPEVNGYAGLLFGNPQLLVSQLIAVASTTAYAFLVTLILAKAVDAAVGLRVSSQEEYVGLDLSQHEEVAYT
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) . Transport is electrogenic . Transport the ammonium and methylammonium cation with high specificity .
O29285
Q21IR9
UBIG_SACD2
3-demethylubiquinone 3-O-methyltransferase
Saccharophagus
MTTQELNVDSAEIAKFERLAARWWDLEGEFKPLHDLNPLRANYIDERAQVAEKKLLDVGCGGGILCEAMAQRGAIVTGIDMGDAPLEVAKLHSLESGVNVDYIKTTAEEFAAKHPQSYDVVTCLEMLEHVPDPAQTIAACAQLVKPGGDIFFSTINRNPKAYLFAVVGAEYVLKMLPKGTHDYNKFIRPSELAQWMRNAGLELQEMCGMTYNPITKHYKLNAKDVSVNYIMHARKI
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Q21IR9
B1HVD8
HEM1_LYSSC
Glutamyl-tRNA reductase
Lysinibacillus
MHTIVVGLNYKTAPVEIREKLSFIESELPQAMEALQKQKSILENVIVSTCNRTEIYAVVDQLHTGRHFVKQFLADWFDLPVETFSSYLTIREEDEAVEHLFKVTAGIDSMVLGETQILGQVKKSFLSGQEIGTTGTVYNQLFKQAVTFAKRAHNETAIGENAVSVSYAAVELAKKIFGSLQRKHVAILGAGKMGELAIENLYGSGVGKVTVINRTFEKAESLAAKFHGQAKSMKELQCSLLEADILITSTGATDYVIDYELMQFVERLRKGKPLFMVDIAVPRDIDPRVGDLPNVFLYDIDDLQGIVEANLAERERAAADITDMIGHEVIQFKDWVSTLGVVPVISALRKKANRIQEETMTSIENKMPDLTERERKILSKHTKSIINQLLKEPILQAKEMANSPKANEQLRLFQQIFGIEEAVEAEVQEMTKQELERKERAQATQTSAEPKYSF
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
B1HVD8
Q9FA05
RS10_BRAPL
30S ribosomal protein S10
Brachyspira
MKEQKIRVKLKAFDIELIDQSAQSIVASVKKTGARVSGPIPLPTSIRKVTVIRSPHVNIKSREQFEMRVYKRLIDIFDVTPQTTESLKKLALPAGVDVQLK
Involved in the binding of tRNA to the ribosomes.
Q9FA05
Q96G91
P2Y11_HUMAN
P2Y purinoceptor 11
Homo
MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
Q96G91
B0S0S7
GUAA_FINM2
Glutamine amidotransferase
Finegoldia
MKHQLVIVVDFGGQYNQLIARRVRDLNVYCEVVPYKKALDVIKEKQPIGIIFTGGPNSVYEENSPQIEKEIFELNIPILGMCYGMQLISKDFGGVVEKAKNREFGKTNAKISNQSSILKGMSDESIVWMSHTDFVSEKPEGFDIIQTTDSCPVAAIANEDKKIFAVQYHPEVNHTVEGKTLIKNFLYEICKADGDWTMENFLEEQIQKIRKTVGDKKVLLALSGGVDSSVCAALLSRAIGKNLTCVFVDHGLMRKNEGDEVEAAFKNDELNFVRVNAKDRFLNKLKGVSDPEQKRKIIGEEFIRVFEDEAKKIGSVDFLAQGTIYPDVIESGQGDASVIKSHHNVGGLPDVVDFKDLIEPLRDLFKDEVRRLGLELEMPEYLVYRQPFPGPGLGIRVMGEITEEKLEVLREADFIFRDEVAKAGIDKDINQYFAVITNNRTVGVMGDFRTYDYTLALRAVTTTDFMTADWARIPYEVLDKTSVRIINEVDHINRIVYDITSKPPATIEWE
Catalyzes the synthesis of GMP from XMP.
B0S0S7
Q660M8
POTA_BORGP
Spermidine/putrescine import ATP-binding protein PotA
Borreliella
MDNCILEIRNLSHYYDNNGNKTLDNINLKIKKNEFITLLGPSGCGKTTLIKILGGFLSQKNGEIYFFSKEISKTSPNKREINTVFQNYALFPHMNVFDNISFGLRMKKTPKDIIKEKVKTSLSLIGMPKYAYRNINELSGGQKQRVAIARAMVMEPKLLLLDEPLSALDLKMRQEMQKELKKIQRQLGITFIYVTHDQEEALTMSDRIVVMNEGIILQVGTPEEIYNEPKTKFVADFIGESNIFDGTYKKELVVSLLGYEFECLDKGFEAEEAVDLVIRPEDIKLLPKGKGHLSGIITSAIFQGVHYEMTLEIQKTNWIVQSTRLTKVGEEVDIFLEPDDIHVMHKE
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
Q660M8
O75843
AP1G2_HUMAN
Gamma2-adaptin
Homo
MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLPVESWQ
(Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).
O75843
Q9KGM3
RECR_HALH5
Recombination protein RecR
Halalkalibacterium (ex Joshi et al. 2022)
MQYPEPIAKLIEGFMRLPGIGPKTASRLAFFVLEMKEDDVLDFAKALVNVKRKLTYCSVCHNITDTDPCRICEDSKRDESVICVVQDAKDVIAMEKMKEYHGKYHVLHGAISPMDGIGPEDIKIPELIKRLQDDTIQEVIVATNPTIEGEATAMYISRLVKPTGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREL
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Q9KGM3
Q61233
PLSL_MOUSE
pp65
Mus
MARGSVSDEEMMELREAFAKVDTDGNGYISCNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGKISFDEFIKVFHGLKSTEVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCTKITNFSTDIKDSKAYYHLLEQVAPKGDEEGIPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILEDIGGGQKVNDDIIVNWVNTTLKEAQKSSSIASFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLDDEEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Q61233
A5UAH8
RUVB_HAEIE
Holliday junction ATP-dependent DNA helicase RuvB
Haemophilus
MIEADRIISGQAKVDEDVIDRAIRPKLLADYVGQPQVREQMDIFIKAAKLRQDALDHLLIFGPPGLGKTTLANIVANEMGVNIRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPAIEEVLYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGSLTSPLRDRFGIVQRLEFYSVEDLTSIVARSAGCLNLELEQQAAFEVARRSRGTPRIANRLLRRVRDYADVRNGGVISVDVAKQALSMLDVDDAGFDYLDRKLLSAVIERFDGGPVGLDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRIATSKTYRHFGLQKLSD
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
A5UAH8
Q8L202
ENO_BARHE
2-phosphoglycerate dehydratase
Bartonella
MTIIVDIIGREVLDSRGNPTVEVEVHLENGALGRALVPSGASTGAHEAVELRDGGTRYQGKGVKKAIAAINGEILEELGGRDARNQIGIDQAMIALDGTPNKARLGANALLGVSLAVAKAAAESLSLPLYRYIGGTQAHILPTPMMNIINGGVHADNPIDFQEFMIIPVGASTLKEAIRYGAEIFHTLKKRLKDAGYNTNVGDEGGFAPQFKSAEQAIDFIMESIIACGYKPGEQIALGLDCAATEFYKNGSYFYEGEGKYRDVGEQVDYLAQLIKTYPIITIEDGMAEDDWEGWKLLTDSIGKKCQLVGDDLFVTNSARLRDGIKMGAANSILIKVNQIGTLSETLDAVETAHKAGYRAIISHRSGETEDSFIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEEMLGLQACYAGNWYC
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Q8L202
Q8MR62
VIAF1_DROME
Viral IAP-associated factor homolog
Sophophora
MQDPNEDTEWNDVLRAKGIIGPKAKEAEITEDQIQKLMDDAIQRRTDLPLNEGQRDKKIDDMSLDELDELEDSEDEAVLEQYRQRRIAEMRATAEKARFGSVREISGQDYVNEVTKAGEGIWVVLHLYANGVPLCALIHHHMQQLAVRFPQTKFVRSVATTCIPNFPEKNLPTIFIYHEGALRKQYIGPLELRGDKLTAEELEFMLGQAGAVPTEITEDPRPQIRDKMLADLEDKSSDFY
Modulates the activation of caspases during apoptosis.
Q8MR62
A0A0K8R374
EV675_IXORI
Evasin P675
Ixodes
MEVKTFAFLQIAVIIALGLHLAPAGSNQLSGPQSSANSNDAVFCDTNCTQGTDGAWSGCRGDCFCVHVGNSTEGRCIELIGDFDYSTPGAED
Salivary chemokine-binding protein which binds to host chemokines CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL10, CXCL11 and CXCL13.
A0A0K8R374
P77744
ABGR_ECOLI
HTH-type transcriptional regulator AbgR
Escherichia
MAFQVKIHQIRAFVEVARQGSIRGASRMLNMSQPALSKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRAAQEDIRQRQGQLAGQINIGMGASISRSLMPAVISRFHQQHPQVKVRIMEGQLVSMINELRQGELDFTINTYYQGPYDHEFTFEKLLEKQFAIFCRPGHPAIGARSIKQLLDYSWTMPTPHGSYYKQLSELLDDQAQTPQVGVVCETFSACISLVAKSDFLSKLPEEMGCDPLHGQGLVMLPVSEILPKAAYYLIQRRDSRQTPLTASLITQFRRECGYLQS
Could be the regulator of the abg operon.
P77744
A0A1D8PCI6
RS4_CANAL
40S ribosomal protein S4
Candida
MARGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVVFLRNRLKYALNGREVKAIMMQQHVQVDGKVRTDTTYPAGFMDVITLEATNEHFRLVYDVKGKFAVHRISAEEAAYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPLIRANDTVKIDLATGKIDDFIKFDTGRLVMVTGGRNLGRVGVIVHREKHEGGFDLVHIKDALENTFVTRLSNVFVIGTEAGKPWVSLPKGKGIKLSISEERDRRRAQQGL
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
A0A1D8PCI6
Q4FMU2
SELO_PELUB
Protein adenylyltransferase SelO
Candidatus Pelagibacter
MTIGWHFDNSYSRLPKTFKENINPVAVNAPEILILNKDLANKLDLDFSNINDDDLSKIFSGNLLPEGSNSIAQAYAGHQFGHFTMLGDGRAVLIGEHLTKNNERFDIQFKGSGRTPFSRSGDGRAVLGPMLREYIISEAMHFLKIPTTRSLAVVKTGEDVVREQISQGAILTRVALGHLRVGTFQYIAAKQNISDLEILINYTIEKYYPNIKSSKNKALDLLNVLIEKQTQLVIDWMRVGFIHGVMNTDNMSISGETIDYGPCAFMDVYDPKTVFSSIDQLGRYAYENQPKITKWNLTRFAECLIPLISTNEDEAIKLATEALDKFEQNYETKWLNMMRDKLGLYGEDKEDKNLIMELLNWMKEKKADYTNTFIFLMNKTIKNSEVYDNADFDLWKTKWMKRLVMFGNTHDKSVDLMSSCNPMVIPRNHKIEEALMLANNGDLTLFNKLIKILKNPYLVNNGDLELMSPAPHSDEKYQTFCGT
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
Q4FMU2
Q975U2
PAN_SULTO
Proteasome regulatory particle
Sulfurisphaera
MSDELDSYRAKHYNSDDPIVRLLEEKIESLTKELEKLRQDLNWYKGELEKLLAPPYIEAIVLDILPDGKVIVRSSSGPNLIVNVSSNIDIKKLKPGSLVALTQRGSTIVEVLPEREDAYVKSFEVIEKPNVHYSDIGGLNEQINEIREVIELPLKNPELFKEIGIDPPKGVLLYGPPGTGKTLLAKAVATESNATFIQVVASEFAQKFVGEGARIVREVFELARRKAPSIVFIDEIDAIGAKRVDMGTSGEREIQRTLMQLLAEIDGFKPLDNVKIIAATNRLDILDPALLRPGRFDRLIEVPLPNFEGRKEIFRIYLQKMKTDGNIRYDILASMTEGFSGAEIKNVCTEAGYIAIRNGRKYVNMTDLITAIEKIKAKNNKAKNTDRTEKYV
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Q975U2
Q9LWN0
GSK1_ORYSJ
Shaggy/GSK3-like kinase 21
Oryza sativa
MEAPPGPEPMELDAPPPPAAVAAAAATAGISEKVLQKKEEGGGDAVTGHIISTTIGGKNGEPKRTISYMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRAMEHPNVICLKHCFFSTTSRDELFLNLVMEYVPETLYRVLKHYSNANQRMPLIYVKLYIYQLFRGLAYIHTVPGVCHRDVKPQNVLVDPLTHQVKLCDFGSAKVLVPGEPNISYICSRYYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGESAVDQLVEIIKVLGTPTREEIRCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAIDLASRLLQYSPSLRCTALDACAHSFFDELREPNARLPNGRPFPPLFNFKHELASASPELIHRLIPDHIRRQHGLNFAHAGS
Probable serine-threonine kinase that may act as a negative regulator of brassinosteroid (BR) signaling during flower development. May have physiological roles in stress signal-transduction pathways . Phosphorylates LIC in response to BR perception .
Q9LWN0
Q9X1X6
ASPD_THEMA
L-aspartate dehydrogenase
Thermotoga
MTVLIIGMGNIGKKLVELGNFEKIYAYDRISKDIPGVVRLDEFQVPSDVSTVVECASPEAVKEYSLQILKNPVNYIIISTSAFADEVFRERFFSELKNSPARVFFPSGAIGGLDVLSSIKDFVKNVRIETIKPPKSLGLDLKGKTVVFEGSVEEASKLFPRNINVASTIGLIVGFEKVKVTIVADPAMDHNIHIVRISSAIGNYEFKIENIPSPENPKTSMLTVYSILRTLRNLESKIIFG
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Does not show aspartate oxidase activity. Is also able to catalyze the reverse reaction, i.e. the reductive amination of oxaloacetate.
Q9X1X6
Q16665
HIF1A_HUMAN
PAS domain-containing protein 8
Homo
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
(Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state . In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons . Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response .
Q16665
P81078
CYC31_DESAC
Cytochrome c3, 10 kDa
Desulfuromonas
ADSLTQFDGIKGRYSHEAFYEEKACDSCHLNK
Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.
P81078
Q39027
MPK7_ARATH
Mitogen-activated protein kinase 7
Arabidopsis
MAMLVEPPNGIKQQGKHYYSMWQTLFEIDTKYVPIKPIGRGAYGVVCSSINRETNERVAIKKIHNVFENRVDALRTLRELKLLRHVRHENVIALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESDIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAIDLLQRMLVFDPTKRISVTDALLHPYMAGLFDPGSNPPAHVPISLDIDENMEEPVIREMMWNEMLYYHPEAEISNA
MKK3-MPK7 module acts as a positive regulator of PR1 gene expression.
Q39027
A4QJB9
NDHK_AETCO
NADH-plastoquinone oxidoreductase subunit K
Aethionema
MNSIKFPVLDRTTKNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKIAREIYKDKIRPQQGNRCFTTNHKFFIVRSTDTGNSDQELLYPPSSTSEISTETFFKYKSPVSSHELVNSGGF
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
A4QJB9
B7J3V1
MURC_ACIF2
UDP-N-acetylmuramoyl-L-alanine synthetase
Acidithiobacillus
MRNWVRQIHMVGIGGSGMRGIAEVLLNLGYAVSGSDLRPGNSTLRLTDLGARIFSGHEAANVRGADVVVISSAIPESNPEVQAARELRIPVIRRAEMLAELMRFKQGIAIAGTHGKTTTTSLVASILGAGGLDPTFVIGGRLKSAGTHAALGSGEYLVAEADESDASFLYLSPVMAVVTNIDADHMETYGGSLDNLRGAFLQFLQRLPFYGLAVLCTDEAVVAGLIPELRTPVLRYGFGADADLQARDVTVQGIGSRFAVWRRVDSDYVHWLDVELGIPGRHNVLNALAAIGIASKVGIPESTIATALADFRGVGRRFELVGTFDGITVVDDYGHHPREIAATIAAARSVWPERPLVVAFQPHRYSRTQALFADFVSSLAAADRVILTDIYSAGEKALPGVTGRALAEAMAAQGMSVRFLPDLLTAPQQIRAELPAGAVLLTLGAGSIASLAAQWPQVFGEDPS
Cell wall formation.
B7J3V1
P19108
ARRB_DROMI
Phosrestin I
Sophophora
MVVSVKVFKKATPNGKVTFYLGRRDFIDHLDYCDPVDGVIVVEPEYLKNRKVFGQLATTYRYGREEDEVMGVKFSKELILSRDEIVPMTNPNMEMTPMQEKLVRKLGSNAHPFTFHFPPNSPSSVTLQQEGDDNGKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISLEVTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVNAQFSKHVAQLETKEGCPITPGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKNTGDACGIVISYSVRIKLNCGTLGGEMQTDVPFKLLQPAPGTIEKKRSNAMKKMKSIEQHRNVKGYYQDDDDNIVFEDFAKMRMNNVNMAD
Undergoes light-induced phosphorylation, probably plays an important role in the photoreceptor transduction.
P19108
B6QAR7
DRE2_TALMQ
Anamorsin homolog
Talaromyces sect. Talaromyces
MPSLPVLIDTTPDFDFAPAQDATQKRTLLLAPPSIAAHEEKLRDIFATFDRSVTDLQMLDRLSAGFVTLPASAYDLVLVLTDTNGARRNEALGLLTRDVFNVLTPAMKPSAQLKLQDGPFQATEGREAILAGLVENNGAFEKPQYQEAAVPLRFGLKKKNKVAPEPVKVESVGFVDNYDDDELIDEDDLLAEEDLGRPVQQPAECKPDIAKKRRRACKDCTCGLAAQLEAEDAERREKANAELNVLKLKTDELNDEVDFTVQGKTGSCNSCSLGDAFRCEGCPFIGLPAFKPGEEVRIMNDMAQL
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
B6QAR7
Q49539
DNAK_MESH2
P65
Mesomycoplasma
MAKEIILGIDLGTTNSVVAIIENQKPVVLENPNGKRTTPSVVAFKNNEEIVGDAAKRQLETNPEAIASIKRLMGTDKTVRANERDYKPEEISAKILAYLKEYAEKKIGHKVTKAVITVPAYFDNAQREATKNAGKIAGLQVERIINEPTAAALAFGLDKTEKEMKVLVYDLGGGTFDVSVLELSGGTFEVLSTSGDNHLGGDDWDNEIVNWLVKKIKEVYDFDPKSDKMALTRLKEEAEKTKINLSNQSVSTVSLPFLGMGKNGPINVELELKRSEFEKMTAHLIDRTRKPIVDALKQAKIEASDLDEVLLVGGSTRMPAVQSMIEHTLNKKPNRSINPDEVVAIGAAIQGGVLAGEISDVLLLDVTPLTLGIETLGGIATPLIPRNTTIPVTKSQIFSTAEDNQTEVTISVVQGERQLAADNKMLGRFNLSGIEAAPRGLPQIEVSFSIDVNGITTVSAKDKKTGKEQTITIKNTSTLSEEEINKMIQEAEENREADALKKDKIETTVRAEGLINQLEKSITDQGEKIDPKQKELLEKQIQELKDLLKEDKTDELKLKLDQIEAAAQSFAQATAQQANTSESDPKADDSNTIDAEIKQD
Acts as a chaperone.
Q49539
Q9LK29
CYC1A_ARATH
Ubiquinol-cytochrome c reductase complex cytochrome c1 subunit 1
Arabidopsis
MVGGGVIQQILRRKLHSQSLATPVLSWFSSKKAHEDAGSSGVRALALLGAGVTGLLSFSTVASADEAEHGLESPEYPWPHDGILSSYDHASIRRGHQVYQQVCASCHSMSLISYRDLVGVAYTEEEAKAMAAEIEVVDGPNDEGEMFTRPGKLSDRFPQPYANESAARFANGGAYPPDLSLITKARHNGPNYVFALLTGYRDPPAGISIREGLHYNPYFPGGAIAMPKMLNDEAVEYEDGVPATEAQMGKDIVSFLAWAAEPEMEERKLMGFKWIFLLSLALLQAAYYRRLKWSVLKSRKLVLDVVN
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c.
Q9LK29
B2SLC0
MURB_XANOP
UDP-N-acetylmuramate dehydrogenase
Xanthomonas
MSDTTQVGWQLSEHAPLRALNTFHVEATARWLLSVHTPEALPQALAAPEIADQPLLVLGSGSNVLLAGDPPGCVLCFENRDTAIIAHHADHAIVRAGAGVNWHALVLYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVGDFIHVVEAFDRHHQQFVRLDAAACALGYRDSVFKQQPERYLIVAVEFNLPLLCELRLDYAGIREELASMGAELARAADVAQAVINIRQRKLPDPDVLGNAGSFFKNPLLPNEQIAALQASFADMPVYPGEHAGLGKLSAAWLIEQCGWKGRREGDAGVSPEHALVLVNYGTASGAQLLDFARRIAESVRERYSVILEPEPRIIGAHW
Cell wall formation.
B2SLC0
Q8BZN4
NUAK2_MOUSE
Omphalocele kinase 2
Mus
MESVALLQRPSQAPSASALASESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGEQEALREGGHPSGDFGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTVPGLERQHSLKKSRKENDMAQNLQGDPAEDTSSRPGKSSLKLPKGILKKKSSTSSGEVQEDPQELRPVPDTPGQPVPAVSLLPRKGILKKSRQRESGYYSSPEPSESGELLDASDVFVSGDPVEQKSPQASGLLLHRKGILKLNGKFSRTALEGTTPSTFGSLDQLASSHPAARPSRPSGAVSEDSILSSESFDQLDLPERLPETPLRGCVSVDNLRGLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.
Q8BZN4
P83409
FABPL_RHIAE
Liver-type fatty acid-binding protein
Rhinella
MAFNGTWNVYAQENYENFLRTVGLPEDIIKVAKDVNPVIEIEQNGNEFVVTSKTPKQTHSNSFTVGKESEITSMDGKKIKVTVQLEGGKLICKSDKFSHIQEVNGDEMVEKITIGSSTLTRKSKRV
Involved in intracellular lipid transport. Binds free fatty acids and their coenzyme A derivatives, lysophospholipids, prostaglandins, retinoids, bilirubin and some other small molecules.
P83409
Q2G870
KUP2_NOVAD
Probable potassium transport system protein kup 2
Novosphingobium
MQTITRTSRNSLASLTLGAIGVVYGDIGTSPLYAFREALGQAARDGIVQAEIVGVLSLALWALIIVVTLKYVIFLSRMDNNGEGGVLSLMALAQRATGGGWVAVTLLGATGAALFYGDAIITPALSVLSAAEGLKTIPGLDGMSQTAIIGVTVGILAALFMFQSRGTASVATLFGPVCLVWFVALAGLGLWHIADAPEVLTAFNPLHAVTFLVSHGVTGLFVLGAVFLTVTGAEALIADMGHFGRRPIQLGWLSFVWPALTLNYLGQGALALKALAAAEAIGQPLANADWFFIMAPDVLRAPLVILATLATIIASQAVITGAYSLTHQAISLGLLPRLTIRQTSEHQMGQIYMPGVNWLLLGGVLLLVLGFKSSSAMAAAYGIAVTGTMVVTTCMAFLIAWKYWNWEPVWTALLIAPFLALDLFFFGANILRVSEGGWVPLLVAGLVGLVIFTWLKGRRTALARASEQGVSLNETVMALHARPPTRIEGTAVFLTQDLDVTPSALLHNLKHNKALHRNNIVLKVEIQARPYVAPEQRVVVDRIDESFLKARLRYGYMDTIDVPSDLARADGLLVGPGGTSFFVGRSAIRFAARPVLPRWMTVVYMFLHRNAADPTAYFSIPSNRVVELGSQIEL
Transport of potassium into the cell.
Q2G870
I3BN39
METAS_THINJ
Homoserine transsuccinylase
Thiothrix
MPLVAHTRLPTFERLKQEGQTVLSEDYAFQQDIRELHIGFLNMMPDAALAATERQFLRLVNESNLIAQFHIHPFTLGTLPRGDKAQAHIAQYYDKFEDLQEQGLDALIITGANPAAPHLEDEPFWDGLCEVVAWAQENVTSTLCSCLASHALVQHLWGIRRRPLGFKRWGVYSHAVTMPEHPLVNDLNTRFDVPHSRFNQIDREPLEAVGVQVLVESTEAGVHMAVSPDLFRMVFMQGHPEYDTVSLLKEYRREVTRWFDGTRADYPPFPQNYLRPKAKAILNEYRLEQEKAKRLGKPLPDFPEKLLLPMLHNTWCDTAKVFYSNWIGKVYQLTNNDRRKPFMEGVNPDDPLGLRQQLGI
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. In vitro, can also use glutaryl-CoA as acyl donor.
I3BN39
A1WW05
HIS6_HALHL
ImGP synthase subunit HisF
Halorhodospira
MTAKRIIPCLDVDAGRVVKGVRFVDIRDAGDPVEIARRYDAMGADELTFLDITASHEERETIYDVVEAVAGQVFIPLTVGGGVRSVADVRRLLNAGADKVAINTAAVHRPDFVREAAERFGSQCIVVAVDAKQVEDDPPRWEVFTHGGRNPTGLEVVSWCQRLVALGAGEILLTSMDRDGTRAGFDLGLTRAVADAVSVPVIASGGVGELEHLADGVDDGGADAVLAASIFHFGDHTVGEAKAHMAERGIEVRR
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A1WW05
B3EUM2
RL4_AMOA5
50S ribosomal protein L4
Candidatus Amoebophilus
MELSVLQYTGKDTGRKVVLSDTIFGITPNDHAIYLDVKNILANKRQGTHKSKERGEIAGSTKKIKKQKGTGTARAGSIKSPIFRGGGRVFGPKPRDYGFKLNKKLKKLARKSALTYKAQQGNISVLEDFSFEMPKTKMYLEMLQNLNMADQKTLLILPAVDKNLVLASRNLPNTSVALVEQINTYDLLYSKKILISETALSKLTENFNNA
Forms part of the polypeptide exit tunnel.
B3EUM2
A1VMW5
RNH_POLNA
Ribonuclease H
Polaromonas
MTDSAAEPTISQPQHVVIYTDGACKGNPGPGGWGALLASGGTEKEIFGGEMGTTNNRMEMTAVIEALAALKKPCTVTLYLDSQYVLKGITEWIHGWKARGWRTAAKAPVKNVDLWQRLDALLVSSGHSIDWRWVRGHNGDPGNERADALANKGVERALGRL
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
A1VMW5
A0T0X8
RK22_THAPS
50S ribosomal protein L22, chloroplastic
Thalassiosira
MSNGQSVKAVAKYVRISPHKVRQVLDQIRGRSYQEALMILEFLPYDAGSPIWQVVHSVAANAKNNYNLDKKKLVISEIFADEGPKLKRIRPRAQGRAYKILKPTCHITVVVKSIS
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
A0T0X8
Q15RL2
RNFD_PSEA6
Rnf electron transport complex subunit D
Pseudoalteromonas
MNYKLASSPHQHVRRNTGQVMRMVIYALIPGILLQTWFFGFGVLVQIALAVITAVVTEATILEMRKRNFERAIKDYSAILTAILLAISIPPFAPWWVIVIGTFFAIAMVKQLYGGLGFNVFNPAMAAYVMLLVSFPVQMTQWLPAQSLTAHQPGLIDAIYAVFTGFSADGFSLAQLQGAADGHTMATPLDAIKTGLAQGLTYEEGLQSAIFDGSLGIGWWWVSTGYLLGGLYLIRAKIINWHIPGGMLAGAALCAGVMFLVDADRFASPLFHIFNGSLILGAFFIATDPVSASTTNKGRIIFGAAIGFWVYVIRTWGGYPDAIAFSVLIMNMAVPLIDYYTRPRTYGHTKRTKGEPK
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
Q15RL2
Q7MZX9
EFP_PHOLL
Elongation factor P
Photorhabdus
MATYSTNEFRSGLKIMLDGEPCAILESEFVKPGKGQAFARVRIRKLISGKLLEKTFKSTDSVESADVMDMNLTYLYNDGEFWHFMNNETFEQLAADEKAVGDNAKWLVEQAECILTLWNGQPISVTPPNFVELEITDTDPGLKGDTAGTGGKPATLNTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
Q7MZX9
Q9UBZ4
APEX2_HUMAN
Apurinic-apyrimidinic endonuclease 2
Homo
MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPLAIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRTVKKPGPNLGRRFYMCARPRGPPTDPSSRCNFFLWSRPS
Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
Q9UBZ4
P39701
COBC_SALTY
Alpha-ribazole-5'-phosphate phosphatase
Salmonella
MRLWLVRHGETEANVAGLYSGHAPTPLTEKGIGQAKTLHTLLRHAPFDRVLCSELERARHTARLVLEGRDVPQHILPELNEMYFGDWEMRHHRDLTHEDAESYAAWCTDWQNAVPTNGEGFQAFTRRVERFISRLDAFSDCQNLLIVSHQGVLSLLIARLLTMPAASLWHFRVEQGCWSAIDICEGFATLKVLNSRAVWRPE
Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin. Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole.
P39701
G1FE62
NDB4A_CHATC
Non-disulfide-bridged peptide 4.10
Chaerilus
MDSKYLFVFLIFNVIVIDLCQGFLWGLIPGAISAVTSLIKKGRRRRELGSQYDYLQDFRKRELDLDDLLSKFPDY
Antimicrobial peptide that acts by breaking the cell wall. Is active against Gram-positive bacteria, fungi and antibiotic-resistant pathogens: S.aureus (MIC=5 ug/ml), M.luteus (MIC=5 ug/ml), B.thuringiensis (MIC=10 ug/ml), B.subtilis (MIC=10 ug/ml), C.albicans (MIC=20 ug/ml), methicillin-resistant S.aureus (MIC=5-10 ug/ml), and penicillin-resistant S.epidermidis (MIC=10 ug/ml). Is efficient in curing staphylococcal skin infection in mice, when externally applied.
G1FE62
A7ZD37
HEM3_CAMC1
Pre-uroporphyrinogen synthase
Campylobacter
MKEIKIATRKSILALWQSEHIKARIEAQHKGMKVVLEGMKTKGDVILDTPLAKIGGKGLFTKELEDSMLKGETDIAVHSLKDVPVVFPEGLRLAAICSREDTRDAMISEKFAKFSDLPHGAKVGTTSLRRKMQLLIMRPDLEIISLRGNVQTRLRKLKEGEFDAIILAMAGINRLNIKAEVAHIYTFGFDEMIPAMGQGALGIEARDEKQILDETSFLNDENAVIETTIERDFVSVLEGGCQVPIGISARLKGDEISIDAIVGLPDGSEYIKDSLKTSKDKFQSVGKELAHKFIEKGARELLKRAEEMA
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A7ZD37
P22433
RBS2_NICSY
Ribulose bisphosphate carboxylase small subunit, chloroplastic 2
Nicotiana
MAFLIMSSAAAVATGTNAAQASMIAPFTGLKSATSFPVSRKQNLDITSIASNGGRVQCMQVWPPINKKKYETLSYLPDLSEEQLLREVEYLLKNGWVPCLEFETEHGFVYRENNKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVEEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
P22433
Q9UT86
APC11_SCHPO
20S cyclosome/APC complex protein apc11
Schizosaccharomyces
MKVKILRYHAIANWTWDTPKDDVCGICRVPFDGCCPQCTSPGDNCPIVWGKCKHIFHAHCIQNWLATSGSQGQCPMDRQTFVVADSTNEKSETQ
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
Q9UT86
A0L4J3
GLMM_MAGMM
Phosphoglucosamine mutase
Magnetococcus
MVQNRAIFCFLSTIKSEETMTSESQPQVTQTRKFFGTDGIRGMANIHPMTPDLVLKLGRAAGHVFRVGDKRHTVIIGKDTRLSGYMFESALLAGLTSMGIHCLQVGPLPTPAIAFLTRALRADAGIMISASHNPFHDNGIKFFGPNGMKLPDELELEIERVLLSDEDLPMPTPHHLGRAHRIDDALGRYIEFAKTSFPKDLRLDGLRVVVDCAHGAAYKVAPAVLWELGAEVVTLGNHPNGTNINDGVGSLYPQEMVKRVQEVRADVGIAFDGDADRVVICDERGEILDGDVILAMSALEMKRKGVLRGDGVVATVMSNLGLERALAAEGLTLARTKVGDRYVLEHMLAHGFNLGGEQSGHLIFLDHNTTGDGLISALSVLALMTTQAQPLSKLANVMQRVPQVLQNVTIARGSDPMDDSRVVAAIAEAEAQLGTRGRILVRKSGTEPKVRVMVEGDDTAHITALASGVCEAIKRASNGFGEG
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
A0L4J3
B2GGG9
SYS_KOCRD
Seryl-tRNA(Ser/Sec) synthetase
Kocuria
MIDINELRADPDTYRASQTARGADAGLVDRILEADSRRRSAITDFESLRAEQNAFGKKVARAQGEEKQQLLAQVKQLAADVKAAQAAADEAQATQQQLVTQFPNLIVEGIPAGGEDDFVQLRTEGTPRDFAAEGFEPRDHLELGELLDGIDMERGAKVSGSRFYFLKRDVARLETALLMAAQDLALDNGFIPMTTPNLVRPGIMNGTGFDVEHDDEIYRVGKDDLYLVGTSEVALAGYHSDEILDLSGGPLRYAGWSSCYRREAGSAGKDTRGIIRVHQFNKLEMFVYCHPEDAAAEHERLLAWEEQMLQACGLAYRVIDTAAGDLGTSAARKFDCEAWIPTQGKYRELTSTSNCTTYQARRLNIRERLPETTDAHGKVKKGGTRAVATLNGTLATTRWLVALLETHQQADGSVTVPELLRPYLRGQEVLRPVA
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
B2GGG9
A7I1B2
ATP6_CAMHC
F-ATPase subunit 6
Campylobacter
MLKDIFLFWGSLFGYDHTAIYIFHFLLVVAITMFIAVAVTKSMRLVPRGLQNIIEAYLSGVIALGKDAMGSEKLARKYMPLIATIGFIVFLSNIIGLIPGFEAPTASLNLTLSLTLCVFFYYHFEGIREKGFIKYFAGFCGPVKAIAPFMFVIEVISHLSRIISLSFRLFGNIKGDDLFLLVMLTLAPVLVPMIPYALLSFMAILQAFIFMVLSYVYLAGAVVVDEEH
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
A7I1B2
B4SPV3
NFUA_STRM5
Fe/S biogenesis protein NfuA
Stenotrophomonas maltophilia group
MIQISDTAQTHFRKLIEREGAPGMGVRLSAVDPGTPRADARLEFAEPSDLLGDEWAVDCDGFTLYVDAASVGWLDGAEIDIVAGTAGAQQLTIKAPRIKGEAPGDAASLVERVHWVVENEINPQLASHGGKVAVQEVSAEGVVLLRFGGGCQGCGMADVTLKQGIEKTLMGRVPGVTAVRDATDHDSGHAPYIPRGNAA
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
B4SPV3
Q3JAN0
UVRC_NITOC
Excinuclease ABC subunit C
Nitrosococcus
MANFDIDDFLRNLTPCPGVYRMLDAKGKVLYVGKAKNLKRRIKSYFRNSKLAPKIHVLVKQICDIKITVTHTENEALILESNLIKALQPRYNVLLRDDKSYPYIFLSADDFPRLGFHRGVKQVSGQYFGPYPNIRSVWQTLKLLQRVFPVRQCEDNFYRNRSRPCLQYQIKRCTAPCVGLISKKDYSQDIQHVVMFLKGRDQQVINELVIRMEEASGQLAFEQAAYYRDRIASLRQIQARQYISGEKKDIDVLGVALTEKMACVEVFFIRGGHNLGNKTFLPKLEGNLTPEELLSTFIAQYYLNRETPPILILSHQPKDMGLLTEVLSKQAGRKIALIKPVRGPKVQWIKMALANAKINLNQHLAEKSNITARFKSLQQLLSLANFPQRIECFDVSHIQGTATVASCVVFDREGPRKADYRRFNITGIIPGDDYGALRQALMRRFKKKEGVFPDLLVIDGGKGQINQSLRVLKEIGITEITVLGIAKGPERKAGNETLFLAGYENPVMVTSDSPALHILQHIRDEAHRFAIVSHRKRRAKGGKLSLLEGISGLGPKRRRKLLIQLGGLQEITRAGVEDLAQIEGISLELAQRIYDVFHR
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q3JAN0
P04991
RBL_MEDSA
Ribulose bisphosphate carboxylase large chain
Medicago
MSPQTETKATVGFKAGVKDYRLTYYTPDYETKDTDILAAFRVSPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEETQFIAYVAYPLDLFEEGSVNYMFTSIVGNVFGFKALRALRLEDLRIPAAYVKTFQGPPQGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTVGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIFFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREATKWSPELAAACEVWKEIKFEFPAMDN
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P04991
Q8AA76
YIDC_BACTN
Membrane protein YidC
Bacteroides
MDKNTITGLVLIGILLVGFSYLSRPSEEQIAAQKKYYDSIAVVQQQQEALKAKTEAALANENKGAAAAADSSALFFNAMHGTDSKVSIQNSVAEITFTTKGGRVYSAMLKEYKGQDKTNPVVLFDGDDATMSFNFYNKQGAIQTKDYYFEAVNKTDSSVTMRLAADNASYIDFIYTLKPNSYLMNFEIKATGMEGKLASTEYVDIDWTQRARQLEKGFTYENRLSELTYKVKGDNVDNLSAAKDDEKDLGNTAIDWVAFKNQFFSSVFIADQDFNKVSVKSRMEQQGSGYIKDYSAEMSTFFDPSGKQPTEMYFYFGPNHFKTLKALDKGRTEKWELNRLVYLGWPLIRWINQFITINVFDWLSGWGLSMGIVLLILTIMVKVVVYPATWKTYMSSAKMRVLKPKIDEINKKYPKQEDAMKKQQEVMSLYSQYGVSPMGGCLPMLLQFPILMALFMFVPSAIELRQQSFLWADDLSTYDAFITFPFHIPFLGNHLSLFCLLMTVTNILNTKYTMTMQDTGAQPQMAAMKWMMYLMPIMFLFVLNDYPSGLNYYYFVSTLISVGTMILLRKTTDETKLLAILEAKKKDPKQMKKTGFAARLEAMQKQQEQLQQQKQNKR
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Q8AA76
P86265
HS74L_MESAU
Osmotic stress protein 94
Mesocricetus
SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRSQIVTNVRNTIHGFKKIRLPYELQKMPNGSTGVKVRLKVLATTFDPYLGGRVEPPLKSVMDQANLQREDINSIEIVGGATRIPAVKEQVTRFFLKDISTTLNADEAVARNHPAPFSKSIDLPIQSSLYRNAVEEYVYDFRDKFITPEDMNKYGQPIQMKYVEHEERPK
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
P86265
Q2G8Y1
RS10_NOVAD
30S ribosomal protein S10
Novosphingobium
MEAQNIRIRLKAFDHRVLDQATGEIADTARRTGALIRGPIPLPTRIEKFCVNRGPHIDKKSREQFEVRTYKRLLDIVQPNAATVDALMKLDLAAGVNVEIKLA
Involved in the binding of tRNA to the ribosomes.
Q2G8Y1
Q6T269
VKT3_BITGA
Two-Kunitz protease inhibitor
Bitis
PLRPGTEKHTFPFPAEFCNLPADLGPCKNYTGRFYYDSASNKCEVFIYGGCPGNANNFKTREECRKTCVEICILPAELGPCDEYTGRFYYDSASNKCEVFIYGGCQGNANNFKTRDECRKTCVEICILPAELGPCDEYTGRLLLRLGIKQM
Serine protease inhibitor.
Q6T269
Q96QA5
GSDMA_HUMAN
Gasdermin-A, C-terminal
Homo
MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS
Pore-forming protein that causes membrane permeabilization and pyroptosis . Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids . Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate . The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown .
Q96QA5
Q05085
PTR7_ARATH
Protein CHLORINA 1
Arabidopsis
MSLPETKSDDILLDAWDFQGRPADRSKTGGWASAAMILCIEAVERLTTLGIGVNLVTYLTGTMHLGNATAANTVTNFLGTSFMLCLLGGFIADTFLGRYLTIAIFAAIQATGVSILTLSTIIPGLRPPRCNPTTSSHCEQASGIQLTVLYLALYLTALGTGGVKASVSGFGSDQFDETEPKERSKMTYFFNRFFFCINVGSLLAVTVLVYVQDDVGRKWGYGICAFAIVLALSVFLAGTNRYRFKKLIGSPMTQVAAVIVAAWRNRKLELPADPSYLYDVDDIIAAEGSMKGKQKLPHTEQFRSLDKAAIRDQEAGVTSNVFNKWTLSTLTDVEEVKQIVRMLPIWATCILFWTVHAQLTTLSVAQSETLDRSIGSFEIPPASMAVFYVGGLLLTTAVYDRVAIRLCKKLFNYPHGLRPLQRIGLGLFFGSMAMAVAALVELKRLRTAHAHGPTVKTLPLGFYLLIPQYLIVGIGEALIYTGQLDFFLRECPKGMKGMSTGLLLSTLALGFFFSSVLVTIVEKFTGKAHPWIADDLNKGRLYNFYWLVAVLVALNFLIFLVFSKWYVYKEKRLAEVGIELDDEPSIPMGH
Dual affinity nitrate transporter. Involved in proton-dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be involved in the basipetal transport of auxin out of the lateral root tips. Acts as a bidirectional transporter involved in root-to-shoot nitrate translocation. Recognizes specifically nitrate and chlorate, but not nitrite, alanine, sulfate, phosphate or the di-peptide Ala-Ala.
Q05085
Q9UBU6
FA8A1_HUMAN
Autosomal highly conserved protein
Homo
MAEGPEEARGHPPGQDDGGGDHEPVPSLRGPPTTAVPCPRDDPQAEPQAPGRPTAPGLAAAAAADKLEPPRELRKRGEAASGSGAELQEQAGCEAPEAAAPRERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAYCSPQPSPQSFPSGGAAVPQAAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAPVAGLGPRAPHVQASVRATPVTRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSGIKDISKFAMHYIIEEIDEDTSMEDLQKMMVVALIYRLLVCFYEIICIWGAGGATPGKFLLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNGVR
Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD).
Q9UBU6
Q6CMQ1
TVP18_KLULA
Golgi apparatus membrane protein TVP18
Kluyveromyces
MVSVGFLKSMFNVSGMVADLKSSNFSIYGQWISYLNIIFCLAFGIANIFHFSAVIVFSIIAIVQGLIILFIEVPFLLKICPLSDNFIGFVSKFDTNLRRALFYLVMCAIQWCSIIVQSTSLIVVAVGLSITATVYALGAAAGQEFKNSAILSDRGRVAASVTNEAVVRDML
Golgi membrane protein involved in vesicular trafficking.
Q6CMQ1
Q12996
CSTF3_HUMAN
Cleavage stimulation factor 77 kDa subunit
Homo
MSGDGATEQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVEKLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRGCVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLRTEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMKYEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPEYVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYPCSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPPPICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKRIR
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
Q12996
Q0APP7
HFQ_MARMM
RNA-binding protein Hfq
Maricaulis
MSHDKKQNLQDVFLNSVRKTKTPLTIFLVNGVKLQGVVTWFDNFCVLLRRDGLSQLVYKHAISTIMPAAPVSLFEDDKADDDAAEESATD
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Q0APP7
C6Y4D3
ECL1_SCHPO
Extender of the chronological lifespan protein 1
Schizosaccharomyces
MDLDFCTVCGATTQDGSLYCSSECHLLDFTKLDTQTTSNISVSSEYQFLVSEHLAHFHRKSMTSADFPTPRFSAYTKLHA
Involved in chronological cell aging. Extends cell viability after entry into the stationary phase probably through affecting the Pka1-dependent pathway negatively.
C6Y4D3
B6I335
TUSA_ECOSE
tRNA 2-thiouridine synthesizing protein A
Escherichia
MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
B6I335
P68193
SRA_ECO57
30S ribosomal protein S22
Escherichia
MKSNRQARHILGLDHKISNQRKIVTEGDKSSVVNNPTGRKRPAEK
Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein.
P68193